runt-2

Overview


Name	runt-2 (AFJ24720.1)
Smed ID	SMED30013043
Length (bp)	1281

Neoblast Clusters

▻ Sub-lethal Irradiated Surviving X1 and X2 Cell Population

Overview

Single cell RNA-seq of pluripotent neoblasts and its early progenies

We isolated X1 neoblasts cells enriched in high piwi-1 expression (Neoblast Population), and profiled ∼7,614 individual cells via scRNA-seq. Unsupervised analyses uncovered 12 distinct classes from 7,088 high-quality cells. We designated these classes Nb1 to Nb12 and ordered them based on high (Nb1) to low (Nb12) piwi-1 expression levels. We further defined groups of genes that best classified the cells parsed into 12 distinct cell clusters to generate a scaled expression heat map of discriminative gene sets for each cluster. Expression of each cluster’s gene signatures was validated using multiplex fluorescence in situ hybridization (FISH) co-stained with piwi-1 and largely confirmed the cell clusters revealed by scRNA-seq.

We also tested sub-lethal irradiation exposure. To profile rare pluripotent stem cells (PSCs) and avoid interference from immediate progenitor cells, we determined a time point after sub-lethal irradiation (7 DPI) with minimal piwi-1+ cells, followed by isolation and single-cell RNA-seq of 1,200 individual cells derived from X1 (Piwi-1 high) and X2 (Piwi-1 low) cell populations (Sub-lethal Irradiated Surviving X1 and X2 Cell Population)

Explore this single cell expression dataset with our NB Cluster Shiny App

Neoblast Population

t-SNE plot shows two-dimensional representation of global gene expression relationships among all neoblasts (n = 7,088 after filter). Cluster identity was assigned based on the top 10 marker genes of each cluster (Table S2), followed by inspection of RNA in situ hybridization patterns. Neoblast groups, Nb.

Expression of runt-2 (SMED30013043) t-SNE clustered cells

Violin plots show distribution of expression levels for runt-2 (SMED30013043) in cells (dots) of each of the 12 neoblast clusters.

Sub-lethal Irradiated Surviving X1 and X2 Cell Population

t-SNE plot of surviving X1 and X2 cells (n = 1,039 after QC filter) after sub-lethal irradiation. Colors indicate unbiased cell classification via graph-based clustering. SL, sub-lethal irradiated cell groups.

Expression of runt-2 (SMED30013043) in the t-SNE clustered sub-lethally irradiated X1 and X2 cells.

Violin plots show distribution of expression levels for runt-2 (SMED30013043) in cells (dots) of each of the 10 clusters of sub-leathally irradiated X1 and X2 cells.

Embryonic Expression

Davies et. al., 2017

Hover the mouse over a column in the graph to view average RPKM values per sample.
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Embryonic Stages: Y: yolk. S2-S8: Stages 2-8. C4: asexual adult. SX: virgin, sexually mature adult.
For further information about sample preparation and analysis for the single animal RNA-Seq experiment, please refer to the Materials and Methods

Anatomical Expression

PAGE et. al., 2020

SMED30013043

has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGE

PAGE Curations: 12

Expressed In	Reference Transcript	Gene Models	Published Transcript	Transcriptome	Publication
intestinal phagocyte	SMED30013043	h1SMcG0016472	Contig3856	newmark_ests	PMID:23079596 Forsthoefel et al., 2012
intestinal phagocyte	SMED30013043	h1SMcG0016472	Contig3856	uc_Smed_v2	PMID:23079596 Forsthoefel et al., 2012
intestinal phagocyte	SMED30013043	h1SMcG0015526	Contig3856	newmark_ests	PMID:23079596 Forsthoefel et al., 2012
intestinal phagocyte	SMED30013043	h1SMcG0015526	Contig3856	uc_Smed_v2	PMID:23079596 Forsthoefel et al., 2012
nervous system	SMED30013043	h1SMcG0016472	dd_Smed_v4_3565_0_1	dd_Smed_v4	PMID:29674431 Fincher et al., 2018
gut	SMED30013043	h1SMcG0016472	dd_Smed_v4_3565_0_1	dd_Smed_v4	PMID:29674431 Fincher et al., 2018
epidermis	SMED30013043	h1SMcG0016472	dd_Smed_v4_3565_0_1	dd_Smed_v4	PMID:29674431 Fincher et al., 2018
cephalic ganglia	SMED30013043	h1SMcG0016472	dd_Smed_v4_3565_0_1	dd_Smed_v4	PMID:29674431 Fincher et al., 2018
neoblast	SMED30013043	h1SMcG0016472	dd_Smed_v4_3565_0_1	dd_Smed_v4	PMID:29674431 Fincher et al., 2018
parenchymal cell	SMED30013043	h1SMcG0016472	dd_Smed_v4_3565_0_1	dd_Smed_v4	PMID:29674431 Fincher et al., 2018
non-ciliated neuron	SMED30013043	h1SMcG0016472	dd_Smed_v4_3565_0_1	dd_Smed_v4	PMID:29674431 Fincher et al., 2018
epidermis	SMED30013043	h1SMcG0016472	dd_Smed_v4_3565_0_1	dd_Smed_v4	PMID:28292427 Wurtzel et al., 2017

Note: Hover over icons to view figure legend

Homology

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BLAST of runt-2 vs. Ensembl Human
Match: RUNX2 (RUNX family transcription factor 2 [Source:HGNC Symbol;Acc:HGNC:10472])

HSP 1 Score: 147.517 bits (371), Expect = 1.045e-40
Identity = 73/132 (55.30%), Postives = 89/132 (67.42%), Query Frame = 2

Query:  419 HAEFTLKRILKNTDSSFVIPGNPNLLCTQLPSHWRINKALVKTFKVFSLLPVADGTQVILSAGNNENVCAELRGNHSQMKNQSAIFQDLRFLGKSGRGKRFNITITMESYPPQVSVYANAIKVTVDGPREPR 814
            H   T+  I+ +  +  V   +PN LC+ LPSHWR NK L   FKV +L  V DGT V + AGN+EN  AELR   + MKNQ A F DLRF+G+SGRGK F +TIT+ + PPQV+ Y  AIKVTVDGPREPR
Sbjct:   83 HDNRTMVEIIADHPAELVRTDSPNFLCSVLPSHWRCNKTLPVAFKVVALGEVPDGTVVTVMAGNDENYSAELRNASAVMKNQVARFNDLRFVGRSGRGKSFTLTITVFTNPPQVATYHRAIKVTVDGPREPR 214

[Close]

BLAST of runt-2 vs. Ensembl Human
Match: RUNX1 (RUNX family transcription factor 1 [Source:HGNC Symbol;Acc:HGNC:10471])

HSP 1 Score: 146.362 bits (368), Expect = 1.532e-40
Identity = 71/139 (51.08%), Postives = 92/139 (66.19%), Query Frame = 2

Query:  398 CMASELLHAEFTLKRILKNTDSSFVIPGNPNLLCTQLPSHWRINKALVKTFKVFSLLPVADGTQVILSAGNNENVCAELRGNHSQMKNQSAIFQDLRFLGKSGRGKRFNITITMESYPPQVSVYANAIKVTVDGPREPR 814
             +A +L   + ++  +L +     V   +PN LC+ LP+HWR NK L   FKV +L  V DGT V + AGN+EN  AELR   + MKNQ A F DLRF+G+SGRGK F +TIT+ + PPQV+ Y  AIK+TVDGPREPR
Sbjct:   39 ALAGKLRSGDRSMVEVLADHPGELVRTDSPNFLCSVLPTHWRCNKTLPIAFKVVALGDVPDGTLVTVMAGNDENYSAELRNATAAMKNQVARFNDLRFVGRSGRGKSFTLTITVFTNPPQVATYHRAIKITVDGPREPR 177

[Close]

BLAST of runt-2 vs. Ensembl Human
Match: RUNX1 (RUNX family transcription factor 1 [Source:HGNC Symbol;Acc:HGNC:10471])

HSP 1 Score: 146.362 bits (368), Expect = 1.603e-40
Identity = 71/139 (51.08%), Postives = 92/139 (66.19%), Query Frame = 2

Query:  398 CMASELLHAEFTLKRILKNTDSSFVIPGNPNLLCTQLPSHWRINKALVKTFKVFSLLPVADGTQVILSAGNNENVCAELRGNHSQMKNQSAIFQDLRFLGKSGRGKRFNITITMESYPPQVSVYANAIKVTVDGPREPR 814
             +A +L   + ++  +L +     V   +PN LC+ LP+HWR NK L   FKV +L  V DGT V + AGN+EN  AELR   + MKNQ A F DLRF+G+SGRGK F +TIT+ + PPQV+ Y  AIK+TVDGPREPR
Sbjct:   54 ALAGKLRSGDRSMVEVLADHPGELVRTDSPNFLCSVLPTHWRCNKTLPIAFKVVALGDVPDGTLVTVMAGNDENYSAELRNATAAMKNQVARFNDLRFVGRSGRGKSFTLTITVFTNPPQVATYHRAIKITVDGPREPR 192

[Close]

BLAST of runt-2 vs. Ensembl Human
Match: RUNX2 (RUNX family transcription factor 2 [Source:HGNC Symbol;Acc:HGNC:10472])

HSP 1 Score: 147.132 bits (370), Expect = 5.520e-40
Identity = 73/132 (55.30%), Postives = 89/132 (67.42%), Query Frame = 2

Query:  419 HAEFTLKRILKNTDSSFVIPGNPNLLCTQLPSHWRINKALVKTFKVFSLLPVADGTQVILSAGNNENVCAELRGNHSQMKNQSAIFQDLRFLGKSGRGKRFNITITMESYPPQVSVYANAIKVTVDGPREPR 814
            H   T+  I+ +  +  V   +PN LC+ LPSHWR NK L   FKV +L  V DGT V + AGN+EN  AELR   + MKNQ A F DLRF+G+SGRGK F +TIT+ + PPQV+ Y  AIKVTVDGPREPR
Sbjct:   83 HDNRTMVEIIADHPAELVRTDSPNFLCSVLPSHWRCNKTLPVAFKVVALGEVPDGTVVTVMAGNDENYSAELRNASAVMKNQVARFNDLRFVGRSGRGKSFTLTITVFTNPPQVATYHRAIKVTVDGPREPR 214

[Close]

BLAST of runt-2 vs. Ensembl Human
Match: RUNX1 (RUNX family transcription factor 1 [Source:HGNC Symbol;Acc:HGNC:10471])

HSP 1 Score: 145.976 bits (367), Expect = 5.006e-39
Identity = 71/139 (51.08%), Postives = 92/139 (66.19%), Query Frame = 2

Query:  398 CMASELLHAEFTLKRILKNTDSSFVIPGNPNLLCTQLPSHWRINKALVKTFKVFSLLPVADGTQVILSAGNNENVCAELRGNHSQMKNQSAIFQDLRFLGKSGRGKRFNITITMESYPPQVSVYANAIKVTVDGPREPR 814
             +A +L   + ++  +L +     V   +PN LC+ LP+HWR NK L   FKV +L  V DGT V + AGN+EN  AELR   + MKNQ A F DLRF+G+SGRGK F +TIT+ + PPQV+ Y  AIK+TVDGPREPR
Sbjct:   39 ALAGKLRSGDRSMVEVLADHPGELVRTDSPNFLCSVLPTHWRCNKTLPIAFKVVALGDVPDGTLVTVMAGNDENYSAELRNATAAMKNQVARFNDLRFVGRSGRGKSFTLTITVFTNPPQVATYHRAIKITVDGPREPR 177

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BLAST of runt-2 vs. Ensembl Celegans
Match: rnt-1 (RNT-1; RuNT related; Transcription factor RUN [Source:UniProtKB/TrEMBL;Acc:G5EFQ5])

HSP 1 Score: 119.783 bits (299), Expect = 1.501e-30
Identity = 55/112 (49.11%), Postives = 75/112 (66.96%), Query Frame = 2

Query:  479 GNPNLLCTQLPSHWRINKALVKTFKVFSLLPVADGTQVILSAGNNENVCAELRGNHSQMKNQSAIFQDLRFLGKSGRGKRFNITITMESYPPQVSVYANAIKVTVDGPREPR 814
             +PN+L T LP HWR NK+  + F V  L PV D T+V + AGN+E  C E+R   +++  Q A F DLRF+G+SGRG++F++TI + S P  V+   N IKVTVDGPR+ R
Sbjct:   26 SSPNILYTALPKHWRSNKSFQEPFYVVLLTPVPDNTEVSIWAGNDEKPCEEVRNEKAKVHRQVAKFNDLRFVGRSGRGRKFHLTIVIHSAPMMVATVKNVIKVTVDGPRDAR 137

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Query:  479 GNPNLLCTQLPSHWRINKALVKTFKVFSLLPVADGTQVILSAGNNENVCAELRGNHSQMKNQSAIFQDLRFLGKSGRGKRFNITITMESYPPQVSVYANAIKVTVDGPREPR 814
             +PN+L T LP HWR NK+  + F V  L PV D T+V + AGN+E  C E+R   +++  Q A F DLRF+G+SGRG++F++TI + S P  V+   N IKVTVDGPR+ R
Sbjct:   26 SSPNILYTALPKHWRSNKSFQEPFYVVLLTPVPDNTEVSIWAGNDEKPCEEVRNEKAKVHRQVAKFNDLRFVGRSGRGRKFHLTIVIHSAPMMVATVKNVIKVTVDGPRDAR 137

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BLAST of runt-2 vs. Ensembl Fly
Match: lz (gene:FBgn0002576 transcript:FBtr0071320)

HSP 1 Score: 157.147 bits (396), Expect = 2.404e-41
Identity = 84/186 (45.16%), Postives = 110/186 (59.14%), Query Frame = 2

Query:  410 ELLHAEFTLKRILKNTDSSFVIPGNPNLLCTQLPSHWRINKALVKTFKVFSLLPVADGTQVILSAGNNENVCAELRGNHSQMKNQSAIFQDLRFLGKSGRGKRFNITITMESYPPQVSVYANAIKVTVDGPREPRSNNGSSLKVNKPIRQSPCKFPTYSSPVIEKQLLLDVIQQTADIRRL-NLKR 964
            +LL  E  +++  +      V   NP  LC+ LP+HWR NK L   FKV +L  V DGT V + AGN+EN CAELR   +QMKN  A F DLRF+G+SGRGK F +TIT+ + PPQV+ YA AIKVTVDGPREPRS            + SP   P Y +  + ++  +D    T  +  L +L+R
Sbjct:  268 DLLWMERLVQKRQQEHPGELVRTSNPYFLCSALPAHWRSNKTLPMAFKVVALAEVGDGTYVTIRAGNDENCCAELRNFTTQMKNDVAKFNDLRFVGRSGRGKSFTLTITVATSPPQVATYAKAIKVTVDGPREPRS------------KTSPTGGPHYRALGLGQRPYIDGFPSTKALHELESLRR 441

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BLAST of runt-2 vs. Ensembl Fly
Match: lz (gene:FBgn0002576 transcript:FBtr0112814)

HSP 1 Score: 155.221 bits (391), Expect = 5.543e-41
Identity = 75/136 (55.15%), Postives = 92/136 (67.65%), Query Frame = 2

Query:  410 ELLHAEFTLKRILKNTDSSFVIPGNPNLLCTQLPSHWRINKALVKTFKVFSLLPVADGTQVILSAGNNENVCAELRGNHSQMKNQSAIFQDLRFLGKSGRGKRFNITITMESYPPQVSVYANAIKVTVDGPREPRS 817
            +LL  E  +++  +      V   NP  LC+ LP+HWR NK L   FKV +L  V DGT V + AGN+EN CAELR   +QMKN  A F DLRF+G+SGRGK F +TIT+ + PPQV+ YA AIKVTVDGPREPRS
Sbjct:  268 DLLWMERLVQKRQQEHPGELVRTSNPYFLCSALPAHWRSNKTLPMAFKVVALAEVGDGTYVTIRAGNDENCCAELRNFTTQMKNDVAKFNDLRFVGRSGRGKSFTLTITVATSPPQVATYAKAIKVTVDGPREPRS 403

[Close]

BLAST of runt-2 vs. Ensembl Fly
Match: run (gene:FBgn0003300 transcript:FBtr0345922)

HSP 1 Score: 150.599 bits (379), Expect = 3.334e-40
Identity = 72/144 (50.00%), Postives = 95/144 (65.97%), Query Frame = 2

Query:  386 ENKYCMASELLHAEFTLKRILKNTDSSFVIPGNPNLLCTQLPSHWRINKALVKTFKVFSLLPVADGTQVILSAGNNENVCAELRGNHSQMKNQSAIFQDLRFLGKSGRGKRFNITITMESYPPQVSVYANAIKVTVDGPREPRS 817
            +N   M S +     +L  +L+         G+P++LC+ LP+HWR NK+L   FKV +L  V DGT V +  GN+EN C ELR   + MKNQ A F DLRF+G+SGRGK F +TIT+ +YP Q++ Y+ AIKVTVDGPREPRS
Sbjct:   91 QNSAKMPSSMTDMFASLHEMLQEYHGELAQTGSPSILCSALPNHWRSNKSLPGAFKVIALDDVPDGTLVSIKCGNDENYCGELRNCTTTMKNQVAKFNDLRFVGRSGRGKSFTLTITIATYPVQIASYSKAIKVTVDGPREPRS 234

[Close]

BLAST of runt-2 vs. Ensembl Fly
Match: run (gene:FBgn0003300 transcript:FBtr0077279)

HSP 1 Score: 150.599 bits (379), Expect = 3.334e-40
Identity = 72/144 (50.00%), Postives = 95/144 (65.97%), Query Frame = 2

Query:  386 ENKYCMASELLHAEFTLKRILKNTDSSFVIPGNPNLLCTQLPSHWRINKALVKTFKVFSLLPVADGTQVILSAGNNENVCAELRGNHSQMKNQSAIFQDLRFLGKSGRGKRFNITITMESYPPQVSVYANAIKVTVDGPREPRS 817
            +N   M S +     +L  +L+         G+P++LC+ LP+HWR NK+L   FKV +L  V DGT V +  GN+EN C ELR   + MKNQ A F DLRF+G+SGRGK F +TIT+ +YP Q++ Y+ AIKVTVDGPREPRS
Sbjct:   91 QNSAKMPSSMTDMFASLHEMLQEYHGELAQTGSPSILCSALPNHWRSNKSLPGAFKVIALDDVPDGTLVSIKCGNDENYCGELRNCTTTMKNQVAKFNDLRFVGRSGRGKSFTLTITIATYPVQIASYSKAIKVTVDGPREPRS 234

[Close]

BLAST of runt-2 vs. Ensembl Fly
Match: run (gene:FBgn0003300 transcript:FBtr0304593)

HSP 1 Score: 150.599 bits (379), Expect = 3.499e-40
Identity = 72/144 (50.00%), Postives = 95/144 (65.97%), Query Frame = 2

Query:  386 ENKYCMASELLHAEFTLKRILKNTDSSFVIPGNPNLLCTQLPSHWRINKALVKTFKVFSLLPVADGTQVILSAGNNENVCAELRGNHSQMKNQSAIFQDLRFLGKSGRGKRFNITITMESYPPQVSVYANAIKVTVDGPREPRS 817
            +N   M S +     +L  +L+         G+P++LC+ LP+HWR NK+L   FKV +L  V DGT V +  GN+EN C ELR   + MKNQ A F DLRF+G+SGRGK F +TIT+ +YP Q++ Y+ AIKVTVDGPREPRS
Sbjct:   91 QNSAKMPSSMTDMFASLHEMLQEYHGELAQTGSPSILCSALPNHWRSNKSLPGAFKVIALDDVPDGTLVSIKCGNDENYCGELRNCTTTMKNQVAKFNDLRFVGRSGRGKSFTLTITIATYPVQIASYSKAIKVTVDGPREPRS 234

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BLAST of runt-2 vs. Ensembl Zebrafish
Match: runx2a (RUNX family transcription factor 2a [Source:ZFIN;Acc:ZDB-GENE-040629-3])

HSP 1 Score: 146.362 bits (368), Expect = 6.193e-41
Identity = 73/132 (55.30%), Postives = 89/132 (67.42%), Query Frame = 2

Query:  419 HAEFTLKRILKNTDSSFVIPGNPNLLCTQLPSHWRINKALVKTFKVFSLLPVADGTQVILSAGNNENVCAELRGNHSQMKNQSAIFQDLRFLGKSGRGKRFNITITMESYPPQVSVYANAIKVTVDGPREPR 814
            H   T+  I+ +  +  V   +PN LC+ LPSHWR NK L   FKV +L  V DGT V + AGN+EN  AELR   + MKNQ A F DLRF+G+SGRGK F +TIT+ + PPQV+ Y  AIKVTVDGPREPR
Sbjct:   44 HDNRTMVEIIADHPAELVRTDSPNFLCSVLPSHWRCNKTLPVAFKVVALGDVPDGTVVTVMAGNDENYSAELRNASAVMKNQVARFNDLRFVGRSGRGKSFTLTITVFTNPPQVATYHRAIKVTVDGPREPR 175

[Close]

BLAST of runt-2 vs. Ensembl Zebrafish
Match: runx2a (RUNX family transcription factor 2a [Source:ZFIN;Acc:ZDB-GENE-040629-3])

HSP 1 Score: 146.747 bits (369), Expect = 5.181e-39
Identity = 73/132 (55.30%), Postives = 89/132 (67.42%), Query Frame = 2

Query:  419 HAEFTLKRILKNTDSSFVIPGNPNLLCTQLPSHWRINKALVKTFKVFSLLPVADGTQVILSAGNNENVCAELRGNHSQMKNQSAIFQDLRFLGKSGRGKRFNITITMESYPPQVSVYANAIKVTVDGPREPR 814
            H   T+  I+ +  +  V   +PN LC+ LPSHWR NK L   FKV +L  V DGT V + AGN+EN  AELR   + MKNQ A F DLRF+G+SGRGK F +TIT+ + PPQV+ Y  AIKVTVDGPREPR
Sbjct:   44 HDNRTMVEIIADHPAELVRTDSPNFLCSVLPSHWRCNKTLPVAFKVVALGDVPDGTVVTVMAGNDENYSAELRNASAVMKNQVARFNDLRFVGRSGRGKSFTLTITVFTNPPQVATYHRAIKVTVDGPREPR 175

[Close]

BLAST of runt-2 vs. Ensembl Zebrafish
Match: runx2a (RUNX family transcription factor 2a [Source:ZFIN;Acc:ZDB-GENE-040629-3])

HSP 1 Score: 146.747 bits (369), Expect = 7.614e-39
Identity = 73/132 (55.30%), Postives = 89/132 (67.42%), Query Frame = 2

Query:  419 HAEFTLKRILKNTDSSFVIPGNPNLLCTQLPSHWRINKALVKTFKVFSLLPVADGTQVILSAGNNENVCAELRGNHSQMKNQSAIFQDLRFLGKSGRGKRFNITITMESYPPQVSVYANAIKVTVDGPREPR 814
            H   T+  I+ +  +  V   +PN LC+ LPSHWR NK L   FKV +L  V DGT V + AGN+EN  AELR   + MKNQ A F DLRF+G+SGRGK F +TIT+ + PPQV+ Y  AIKVTVDGPREPR
Sbjct:   58 HDNRTMVEIIADHPAELVRTDSPNFLCSVLPSHWRCNKTLPVAFKVVALGDVPDGTVVTVMAGNDENYSAELRNASAVMKNQVARFNDLRFVGRSGRGKSFTLTITVFTNPPQVATYHRAIKVTVDGPREPR 189

[Close]

BLAST of runt-2 vs. Ensembl Zebrafish
Match: runx3 (RUNX family transcription factor 3 [Source:ZFIN;Acc:ZDB-GENE-000605-2])

HSP 1 Score: 144.05 bits (362), Expect = 3.249e-38
Identity = 74/139 (53.24%), Postives = 92/139 (66.19%), Query Frame = 2

Query:  443 ILKNTDSSFVIPGNPNLLCTQLPSHWRINKALVKTFKVFSLLPVADGTQVILSAGNNENVCAELRGNHSQMKNQSAIFQDLRFLGKSGRGKRFNITITMESYPPQVSVYANAIKVTVDGPREPRSNNGSSLKVNKPIRQ 859
            +L +     V   +PN LC+ LPSHWR NK L   FKV +L  V DGT V + AGN+EN  AELR   + MKNQ A F DLRF+G+SGRGK F +TIT+ + PPQV+ Y  AIKVTVDGPREPR +    +K + P +Q
Sbjct:   51 VLADHAGELVRTDSPNFLCSVLPSHWRCNKTLPVAFKVVALGDVPDGTLVTVMAGNDENYSAELRNASAVMKNQVARFNDLRFVGRSGRGKSFTLTITVFTGPPQVATYHRAIKVTVDGPREPRRHR---VKPDDPHKQ 186

[Close]

Query:  443 ILKNTDSSFVIPGNPNLLCTQLPSHWRINKALVKTFKVFSLLPVADGTQVILSAGNNENVCAELRGNHSQMKNQSAIFQDLRFLGKSGRGKRFNITITMESYPPQVSVYANAIKVTVDGPREPRSNNGSSLKVNKPIRQ 859
            +L +     V   +PN LC+ LPSHWR NK L   FKV +L  V DGT V + AGN+EN  AELR   + MKNQ A F DLRF+G+SGRGK F +TIT+ + PPQV+ Y  AIKVTVDGPREPR +    +K + P +Q
Sbjct:   51 VLADHAGELVRTDSPNFLCSVLPSHWRCNKTLPVAFKVVALGDVPDGTLVTVMAGNDENYSAELRNASAVMKNQVARFNDLRFVGRSGRGKSFTLTITVFTGPPQVATYHRAIKVTVDGPREPRRHR---VKPDDPHKQ 186

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BLAST of runt-2 vs. Ensembl Xenopus
Match: taf4 (TATA-box binding protein associated factor 4 [Source:Xenbase;Acc:XB-GENE-488490])

HSP 1 Score: 145.591 bits (366), Expect = 7.786e-39
Identity = 88/195 (45.13%), Postives = 114/195 (58.46%), Query Frame = 2

Query:  431 TLKRILKNTDSSFVIPGNPNLLCTQLPSHWRINKALVKTFKVFSLLPVADGTQVILSAGNNENVCAELRGNHSQMKNQSAIFQDLRFLGKSGRGKRFNITITMESYPPQVSVYANAIKVTVDGPREPRSNNGSSLKVNKPIRQSPCKFPTY----SSPVIEKQLLLDVIQQT-----ADI-RRLN-LKRLHPLSD 982
            T+  I+ +  +  V   +PN LC+ LPSHWR NK L   FKV +L  V+DG+ V + AGN+EN  AELR   + MKNQ A F DLRF+G+SGRGK F +TIT+ + PPQV+ Y  AIKVTVDGPREPR    +         QS   +P+Y    +SP I     L   + T     +D+ RRL+    L P SD
Sbjct:   61 TMVEIIADHPAELVRTDSPNFLCSVLPSHWRCNKTLPVAFKVVALGEVSDGSVVTVMAGNDENYSAELRNASAVMKNQVARFNDLRFVGRSGRGKSFTLTITVFTNPPQVATYHRAIKVTVDGPREPRHPRQTQSSPPWSYDQS---YPSYLSQMTSPSIHSTTPLSSTRGTGLPAISDVPRRLSGASELGPFSD 252

[Close]

BLAST of runt-2 vs. Ensembl Xenopus
Match: znf385d (zinc finger protein 385D [Source:Xenbase;Acc:XB-GENE-1216182])

HSP 1 Score: 144.05 bits (362), Expect = 3.244e-38
Identity = 71/147 (48.30%), Postives = 93/147 (63.27%), Query Frame = 2

Query:  374 LTRIENKYCMASELLHAEFTLKRILKNTDSSFVIPGNPNLLCTQLPSHWRINKALVKTFKVFSLLPVADGTQVILSAGNNENVCAELRGNHSQMKNQSAIFQDLRFLGKSGRGKRFNITITMESYPPQVSVYANAIKVTVDGPREPR 814
            L   ++   +  +L   +  +  +L +     V   +PN LC+ LP+HWR NK L   FKV +L  V DGT V + AGN+EN  AELR   + MKNQ A F DLRF+G+SGRGK F +TIT+ + PPQV+ Y  AIK+TVDGPREPR
Sbjct:   31 LNVTDSSAALVGKLRSTDRNMVEVLSDHPGELVRTDSPNFLCSVLPTHWRCNKTLPIAFKVVALGDVPDGTLVTVMAGNDENYSAELRNATAAMKNQVARFNDLRFVGRSGRGKSFTLTITVFTNPPQVATYHRAIKITVDGPREPR 177

[Close]

BLAST of runt-2 vs. Ensembl Xenopus
Match: taf4 (TATA-box binding protein associated factor 4 [Source:Xenbase;Acc:XB-GENE-488490])

HSP 1 Score: 144.436 bits (363), Expect = 4.983e-38
Identity = 71/128 (55.47%), Postives = 89/128 (69.53%), Query Frame = 2

Query:  431 TLKRILKNTDSSFVIPGNPNLLCTQLPSHWRINKALVKTFKVFSLLPVADGTQVILSAGNNENVCAELRGNHSQMKNQSAIFQDLRFLGKSGRGKRFNITITMESYPPQVSVYANAIKVTVDGPREPR 814
            T+  I+ +  +  V   +PN LC+ LPSHWR NK L   FKV +L  V+DG+ V + AGN+EN  AELR   + MKNQ A F DLRF+G+SGRGK F +TIT+ + PPQV+ Y  AIKVTVDGPREPR
Sbjct:   61 TMVEIIADHPAELVRTDSPNFLCSVLPSHWRCNKTLPVAFKVVALGEVSDGSVVTVMAGNDENYSAELRNASAVMKNQVARFNDLRFVGRSGRGKSFTLTITVFTNPPQVATYHRAIKVTVDGPREPR 188

[Close]

BLAST of runt-2 vs. Ensembl Xenopus
Match: taf4 (TATA-box binding protein associated factor 4 [Source:Xenbase;Acc:XB-GENE-488490])

HSP 1 Score: 144.05 bits (362), Expect = 8.048e-38
Identity = 71/128 (55.47%), Postives = 89/128 (69.53%), Query Frame = 2

Query:  431 TLKRILKNTDSSFVIPGNPNLLCTQLPSHWRINKALVKTFKVFSLLPVADGTQVILSAGNNENVCAELRGNHSQMKNQSAIFQDLRFLGKSGRGKRFNITITMESYPPQVSVYANAIKVTVDGPREPR 814
            T+  I+ +  +  V   +PN LC+ LPSHWR NK L   FKV +L  V+DG+ V + AGN+EN  AELR   + MKNQ A F DLRF+G+SGRGK F +TIT+ + PPQV+ Y  AIKVTVDGPREPR
Sbjct:   75 TMVEIIADHPAELVRTDSPNFLCSVLPSHWRCNKTLPVAFKVVALGEVSDGSVVTVMAGNDENYSAELRNASAVMKNQVARFNDLRFVGRSGRGKSFTLTITVFTNPPQVATYHRAIKVTVDGPREPR 202

[Close]

BLAST of runt-2 vs. Ensembl Xenopus
Match: znf385d (zinc finger protein 385D [Source:Xenbase;Acc:XB-GENE-1216182])

HSP 1 Score: 144.05 bits (362), Expect = 1.155e-37
Identity = 70/143 (48.95%), Postives = 92/143 (64.34%), Query Frame = 2

Query:  386 ENKYCMASELLHAEFTLKRILKNTDSSFVIPGNPNLLCTQLPSHWRINKALVKTFKVFSLLPVADGTQVILSAGNNENVCAELRGNHSQMKNQSAIFQDLRFLGKSGRGKRFNITITMESYPPQVSVYANAIKVTVDGPREPR 814
            ++   +  +L   +  +  +L +     V   +PN LC+ LP+HWR NK L   FKV +L  V DGT V + AGN+EN  AELR   + MKNQ A F DLRF+G+SGRGK F +TIT+ + PPQV+ Y  AIK+TVDGPREPR
Sbjct:   49 DSSAALVGKLRSTDRNMVEVLSDHPGELVRTDSPNFLCSVLPTHWRCNKTLPIAFKVVALGDVPDGTLVTVMAGNDENYSAELRNATAAMKNQVARFNDLRFVGRSGRGKSFTLTITVFTNPPQVATYHRAIKITVDGPREPR 191

[Close]

BLAST of runt-2 vs. Ensembl Mouse
Match: Runx2 (runt related transcription factor 2 [Source:MGI Symbol;Acc:MGI:99829])

HSP 1 Score: 146.362 bits (368), Expect = 6.957e-41
Identity = 72/128 (56.25%), Postives = 88/128 (68.75%), Query Frame = 2

Query:  431 TLKRILKNTDSSFVIPGNPNLLCTQLPSHWRINKALVKTFKVFSLLPVADGTQVILSAGNNENVCAELRGNHSQMKNQSAIFQDLRFLGKSGRGKRFNITITMESYPPQVSVYANAIKVTVDGPREPR 814
            T+  I+ +  +  V   +PN LC+ LPSHWR NK L   FKV +L  V DGT V + AGN+EN  AELR   + MKNQ A F DLRF+G+SGRGK F +TIT+ + PPQV+ Y  AIKVTVDGPREPR
Sbjct:    5 TMVEIIADHPAELVRTDSPNFLCSVLPSHWRCNKTLPVAFKVVALGEVPDGTVVTVMAGNDENYSAELRNASAVMKNQVARFNDLRFVGRSGRGKSFTLTITVFTNPPQVATYHRAIKVTVDGPREPR 132

[Close]

BLAST of runt-2 vs. Ensembl Mouse
Match: Runx2 (runt related transcription factor 2 [Source:MGI Symbol;Acc:MGI:99829])

HSP 1 Score: 147.517 bits (371), Expect = 1.014e-40
Identity = 73/132 (55.30%), Postives = 89/132 (67.42%), Query Frame = 2

Query:  419 HAEFTLKRILKNTDSSFVIPGNPNLLCTQLPSHWRINKALVKTFKVFSLLPVADGTQVILSAGNNENVCAELRGNHSQMKNQSAIFQDLRFLGKSGRGKRFNITITMESYPPQVSVYANAIKVTVDGPREPR 814
            H   T+  I+ +  +  V   +PN LC+ LPSHWR NK L   FKV +L  V DGT V + AGN+EN  AELR   + MKNQ A F DLRF+G+SGRGK F +TIT+ + PPQV+ Y  AIKVTVDGPREPR
Sbjct:   90 HDNRTMVEIIADHPAELVRTDSPNFLCSVLPSHWRCNKTLPVAFKVVALGEVPDGTVVTVMAGNDENYSAELRNASAVMKNQVARFNDLRFVGRSGRGKSFTLTITVFTNPPQVATYHRAIKVTVDGPREPR 221

[Close]

BLAST of runt-2 vs. Ensembl Mouse
Match: Runx1 (runt related transcription factor 1 [Source:MGI Symbol;Acc:MGI:99852])

HSP 1 Score: 147.517 bits (371), Expect = 8.703e-40
Identity = 73/147 (49.66%), Postives = 95/147 (64.63%), Query Frame = 2

Query:  374 LTRIENKYCMASELLHAEFTLKRILKNTDSSFVIPGNPNLLCTQLPSHWRINKALVKTFKVFSLLPVADGTQVILSAGNNENVCAELRGNHSQMKNQSAIFQDLRFLGKSGRGKRFNITITMESYPPQVSVYANAIKVTVDGPREPR 814
            L   +    +AS+L   + ++  +L +     V   +PN LC+ LP+HWR NK L   FKV +L  V DGT V + AGN+EN  AELR   + MKNQ A F DLRF+G+SGRGK F +TIT+ + PPQV+ Y  AIK+TVDGPREPR
Sbjct:   31 LGAPDGGAALASKLRSGDRSMVEVLADHPGELVRTDSPNFLCSVLPTHWRCNKTLPIAFKVVALGDVPDGTLVTVMAGNDENYSAELRNATAAMKNQVARFNDLRFVGRSGRGKSFTLTITVFTNPPQVATYHRAIKITVDGPREPR 177

[Close]

BLAST of runt-2 vs. Ensembl Mouse
Match: Runx1 (runt related transcription factor 1 [Source:MGI Symbol;Acc:MGI:99852])

HSP 1 Score: 147.517 bits (371), Expect = 2.714e-39
Identity = 72/143 (50.35%), Postives = 94/143 (65.73%), Query Frame = 2

Query:  386 ENKYCMASELLHAEFTLKRILKNTDSSFVIPGNPNLLCTQLPSHWRINKALVKTFKVFSLLPVADGTQVILSAGNNENVCAELRGNHSQMKNQSAIFQDLRFLGKSGRGKRFNITITMESYPPQVSVYANAIKVTVDGPREPR 814
            +    +AS+L   + ++  +L +     V   +PN LC+ LP+HWR NK L   FKV +L  V DGT V + AGN+EN  AELR   + MKNQ A F DLRF+G+SGRGK F +TIT+ + PPQV+ Y  AIK+TVDGPREPR
Sbjct:   35 DGGAALASKLRSGDRSMVEVLADHPGELVRTDSPNFLCSVLPTHWRCNKTLPIAFKVVALGDVPDGTLVTVMAGNDENYSAELRNATAAMKNQVARFNDLRFVGRSGRGKSFTLTITVFTNPPQVATYHRAIKITVDGPREPR 177

[Close]

BLAST of runt-2 vs. Ensembl Mouse
Match: Runx1 (runt related transcription factor 1 [Source:MGI Symbol;Acc:MGI:99852])

HSP 1 Score: 147.517 bits (371), Expect = 3.883e-39
Identity = 73/147 (49.66%), Postives = 95/147 (64.63%), Query Frame = 2

Query:  374 LTRIENKYCMASELLHAEFTLKRILKNTDSSFVIPGNPNLLCTQLPSHWRINKALVKTFKVFSLLPVADGTQVILSAGNNENVCAELRGNHSQMKNQSAIFQDLRFLGKSGRGKRFNITITMESYPPQVSVYANAIKVTVDGPREPR 814
            L   +    +AS+L   + ++  +L +     V   +PN LC+ LP+HWR NK L   FKV +L  V DGT V + AGN+EN  AELR   + MKNQ A F DLRF+G+SGRGK F +TIT+ + PPQV+ Y  AIK+TVDGPREPR
Sbjct:   45 LGAPDGGAALASKLRSGDRSMVEVLADHPGELVRTDSPNFLCSVLPTHWRCNKTLPIAFKVVALGDVPDGTLVTVMAGNDENYSAELRNATAAMKNQVARFNDLRFVGRSGRGKSFTLTITVFTNPPQVATYHRAIKITVDGPREPR 191

[Close]

BLAST of runt-2 vs. UniProt/SwissProt
Match: sp|Q9W349|LOZEN_DROME (Protein lozenge OS=Drosophila melanogaster OX=7227 GN=lz PE=2 SV=2)

HSP 1 Score: 157.147 bits (396), Expect = 2.410e-40
Identity = 84/186 (45.16%), Postives = 110/186 (59.14%), Query Frame = 2

Query:  410 ELLHAEFTLKRILKNTDSSFVIPGNPNLLCTQLPSHWRINKALVKTFKVFSLLPVADGTQVILSAGNNENVCAELRGNHSQMKNQSAIFQDLRFLGKSGRGKRFNITITMESYPPQVSVYANAIKVTVDGPREPRSNNGSSLKVNKPIRQSPCKFPTYSSPVIEKQLLLDVIQQTADIRRL-NLKR 964
            +LL  E  +++  +      V   NP  LC+ LP+HWR NK L   FKV +L  V DGT V + AGN+EN CAELR   +QMKN  A F DLRF+G+SGRGK F +TIT+ + PPQV+ YA AIKVTVDGPREPRS            + SP   P Y +  + ++  +D    T  +  L +L+R
Sbjct:  268 DLLWMERLVQKRQQEHPGELVRTSNPYFLCSALPAHWRSNKTLPMAFKVVALAEVGDGTYVTIRAGNDENCCAELRNFTTQMKNDVAKFNDLRFVGRSGRGKSFTLTITVATSPPQVATYAKAIKVTVDGPREPRS------------KTSPTGGPHYRALGLGQRPYIDGFPSTKALHELESLRR 441

[Close]

BLAST of runt-2 vs. UniProt/SwissProt
Match: sp|P22814|RUNT_DROME (Segmentation protein Runt OS=Drosophila melanogaster OX=7227 GN=run PE=1 SV=2)

HSP 1 Score: 150.599 bits (379), Expect = 3.342e-39
Identity = 72/144 (50.00%), Postives = 95/144 (65.97%), Query Frame = 2

Query:  386 ENKYCMASELLHAEFTLKRILKNTDSSFVIPGNPNLLCTQLPSHWRINKALVKTFKVFSLLPVADGTQVILSAGNNENVCAELRGNHSQMKNQSAIFQDLRFLGKSGRGKRFNITITMESYPPQVSVYANAIKVTVDGPREPRS 817
            +N   M S +     +L  +L+         G+P++LC+ LP+HWR NK+L   FKV +L  V DGT V +  GN+EN C ELR   + MKNQ A F DLRF+G+SGRGK F +TIT+ +YP Q++ Y+ AIKVTVDGPREPRS
Sbjct:   91 QNSAKMPSSMTDMFASLHEMLQEYHGELAQTGSPSILCSALPNHWRSNKSLPGAFKVIALDDVPDGTLVSIKCGNDENYCGELRNCTTTMKNQVAKFNDLRFVGRSGRGKSFTLTITIATYPVQIASYSKAIKVTVDGPREPRS 234

[Close]

BLAST of runt-2 vs. UniProt/SwissProt
Match: sp|Q63046|RUNX1_RAT (Runt-related transcription factor 1 OS=Rattus norvegicus OX=10116 GN=Runx1 PE=1 SV=1)

HSP 1 Score: 147.517 bits (371), Expect = 1.793e-38
Identity = 72/143 (50.35%), Postives = 94/143 (65.73%), Query Frame = 2

Query:  386 ENKYCMASELLHAEFTLKRILKNTDSSFVIPGNPNLLCTQLPSHWRINKALVKTFKVFSLLPVADGTQVILSAGNNENVCAELRGNHSQMKNQSAIFQDLRFLGKSGRGKRFNITITMESYPPQVSVYANAIKVTVDGPREPR 814
            +    +AS+L   + ++  +L +     V   +PN LC+ LP+HWR NK L   FKV +L  V DGT V + AGN+EN  AELR   + MKNQ A F DLRF+G+SGRGK F +TIT+ + PPQV+ Y  AIK+TVDGPREPR
Sbjct:   35 DGGAALASKLRSGDRSMVEVLADHPGELVRTDSPNFLCSVLPTHWRCNKTLPIAFKVVALGDVPDGTLVTVMAGNDENYSAELRNATAAMKNQVARFNDLRFVGRSGRGKSFTLTITVFTNPPQVATYHRAIKITVDGPREPR 177

[Close]

BLAST of runt-2 vs. UniProt/SwissProt
Match: sp|Q03347|RUNX1_MOUSE (Runt-related transcription factor 1 OS=Mus musculus OX=10090 GN=Runx1 PE=1 SV=1)

HSP 1 Score: 147.517 bits (371), Expect = 1.918e-38
Identity = 72/139 (51.80%), Postives = 93/139 (66.91%), Query Frame = 2

Query:  398 CMASELLHAEFTLKRILKNTDSSFVIPGNPNLLCTQLPSHWRINKALVKTFKVFSLLPVADGTQVILSAGNNENVCAELRGNHSQMKNQSAIFQDLRFLGKSGRGKRFNITITMESYPPQVSVYANAIKVTVDGPREPR 814
             +AS+L   + ++  +L +     V   +PN LC+ LP+HWR NK L   FKV +L  V DGT V + AGN+EN  AELR   + MKNQ A F DLRF+G+SGRGK F +TIT+ + PPQV+ Y  AIK+TVDGPREPR
Sbjct:   39 ALASKLRSGDRSMVEVLADHPGELVRTDSPNFLCSVLPTHWRCNKTLPIAFKVVALGDVPDGTLVTVMAGNDENYSAELRNATAAMKNQVARFNDLRFVGRSGRGKSFTLTITVFTNPPQVATYHRAIKITVDGPREPR 177

[Close]

BLAST of runt-2 vs. UniProt/SwissProt
Match: sp|Q01196|RUNX1_HUMAN (Runt-related transcription factor 1 OS=Homo sapiens OX=9606 GN=RUNX1 PE=1 SV=3)

HSP 1 Score: 146.362 bits (368), Expect = 6.558e-38
Identity = 71/139 (51.08%), Postives = 92/139 (66.19%), Query Frame = 2

Query:  398 CMASELLHAEFTLKRILKNTDSSFVIPGNPNLLCTQLPSHWRINKALVKTFKVFSLLPVADGTQVILSAGNNENVCAELRGNHSQMKNQSAIFQDLRFLGKSGRGKRFNITITMESYPPQVSVYANAIKVTVDGPREPR 814
             +A +L   + ++  +L +     V   +PN LC+ LP+HWR NK L   FKV +L  V DGT V + AGN+EN  AELR   + MKNQ A F DLRF+G+SGRGK F +TIT+ + PPQV+ Y  AIK+TVDGPREPR
Sbjct:   39 ALAGKLRSGDRSMVEVLADHPGELVRTDSPNFLCSVLPTHWRCNKTLPIAFKVVALGDVPDGTLVTVMAGNDENYSAELRNATAAMKNQVARFNDLRFVGRSGRGKSFTLTITVFTNPPQVATYHRAIKITVDGPREPR 177

[Close]

BLAST of runt-2 vs. TrEMBL
Match: I1ZI66 (Runt-2 OS=Schmidtea mediterranea OX=79327 PE=2 SV=1)

HSP 1 Score: 298.13 bits (762), Expect = 2.069e-97
Identity = 143/146 (97.95%), Postives = 144/146 (98.63%), Query Frame = 2

Query:  401 MASELLHAEFTLKRILKNTDSSFVIPGNPNLLCTQLPSHWRINKALVKTFKVFSLLPVADGTQVILSAGNNENVCAELRGNHSQMKNQSAIFQDLRFLGKSGRGKRFNITITMESYPPQVSVYANAIKVTVDGPREPRSNNGSSLK 838
            MASELLHAEFTLKRILKNTDSSFVIPGNPNLLCTQLPSHWRINKALVKTFKVFSLLPVADGTQVILSAGNNENVCAELRGNHSQMKNQSAIFQDLRFLGKSGRGKRFNITITMESYPPQVSVYANAIKVTVDGPREPRSNNG S +
Sbjct:    1 MASELLHAEFTLKRILKNTDSSFVIPGNPNLLCTQLPSHWRINKALVKTFKVFSLLPVADGTQVILSAGNNENVCAELRGNHSQMKNQSAIFQDLRFLGKSGRGKRFNITITMESYPPQVSVYANAIKVTVDGPREPRSNNGISWQ 146

[Close]

BLAST of runt-2 vs. TrEMBL
Match: A0A1L7H9X8 (Transcriptional regulatory protein Runt-2 OS=Dugesia japonica OX=6161 PE=2 SV=1)

HSP 1 Score: 287.73 bits (735), Expect = 3.126e-93
Identity = 136/146 (93.15%), Postives = 142/146 (97.26%), Query Frame = 2

Query:  401 MASELLHAEFTLKRILKNTDSSFVIPGNPNLLCTQLPSHWRINKALVKTFKVFSLLPVADGTQVILSAGNNENVCAELRGNHSQMKNQSAIFQDLRFLGKSGRGKRFNITITMESYPPQVSVYANAIKVTVDGPREPRSNNGSSLK 838
            MASELL AEFTLKRILKNTDS+FVIPGNP+LLCTQLPSHWRINKALVKTFKVFSLLPVADGTQVILSAGNNEN+CAELRGN SQMKNQ+AIFQDLRFLGKSGRGKRFNITITMESYPPQVSVYANAIKVTVDGPREPR+NNG S +
Sbjct:    1 MASELLQAEFTLKRILKNTDSTFVIPGNPDLLCTQLPSHWRINKALVKTFKVFSLLPVADGTQVILSAGNNENICAELRGNQSQMKNQTAIFQDLRFLGKSGRGKRFNITITMESYPPQVSVYANAIKVTVDGPREPRTNNGISWQ 146

[Close]

BLAST of runt-2 vs. TrEMBL
Match: A0A183SL26 (Runt domain-containing protein OS=Schistocephalus solidus OX=70667 GN=SSLN_LOCUS4924 PE=4 SV=1)

HSP 1 Score: 172.94 bits (437), Expect = 4.435e-48
Identity = 85/158 (53.80%), Postives = 111/158 (70.25%), Query Frame = 2

Query:  374 LTRIEN-----KYCMASELLHAEFTLKRILKNTDSSFVIPGNPNLLCTQLPSHWRINKALVKTFKVFSLLPVADGTQVILSAGNNENVCAELRGNHSQMKNQSAIFQDLRFLGKSGRGKRFNITITMESYPPQVSVYANAIKVTVDGPREPRSNNGSS 832
            LTRI+      K+   S++L AE+TL+R L       ++ G+P++LC+ LP HWR NK+L   F+V SL+PV DGT+V+L+AGN E   AEL+   + M+NQ A F DLRFLG+SGRGK FN+TIT+ES PPQV  Y+ AIKVTVDGPR PR+  G S
Sbjct:   35 LTRIQGNLGKLKFGHMSDILLAEYTLRRALHEHAGDLMVTGSPHILCSTLPKHWRSNKSLPTPFRVVSLIPVPDGTRVVLTAGNEERPFAELKNAVAIMQNQEARFNDLRFLGRSGRGKSFNVTITVESNPPQVGTYSRAIKVTVDGPRVPRNKYGKS 192

[Close]

BLAST of runt-2 vs. TrEMBL
Match: W6US52 (Runt-related transcription factor OS=Echinococcus granulosus OX=6210 GN=EGR_01216 PE=4 SV=1)

HSP 1 Score: 171.4 bits (433), Expect = 4.754e-47
Identity = 81/142 (57.04%), Postives = 104/142 (73.24%), Query Frame = 2

Query:  401 MASELLHAEFTLKRILKNTDSSFVIPGNPNLLCTQLPSHWRINKALVKTFKVFSLLPVADGTQVILSAGNNENVCAELRGNHSQMKNQSAIFQDLRFLGKSGRGKRFNITITMESYPPQVSVYANAIKVTVDGPREPRSNNG 826
            M+  +L AE+TL+R L       V+ G+P+LLC+ LP HWR NK+L   F+V SL+PV DGT+V+LSAGN E   AEL+   + M+NQ A F DLRFLG+SGRGK FN+TIT+E+ PPQV  Y++AIKVTVDGPR PR+  G
Sbjct:    1 MSDIMLAAEYTLRRALHEHAGDLVVTGSPHLLCSSLPKHWRSNKSLPTPFRVVSLVPVPDGTRVVLSAGNEERPFAELKNAVAVMQNQEARFNDLRFLGRSGRGKSFNVTITVETNPPQVGTYSHAIKVTVDGPRVPRNKYG 142

[Close]

BLAST of runt-2 vs. TrEMBL
Match: A0A0R3TQC1 (Runt domain-containing protein OS=Rodentolepis nana OX=102285 GN=HNAJ_LOCUS9730 PE=4 SV=1)

HSP 1 Score: 166.007 bits (419), Expect = 6.561e-46
Identity = 78/142 (54.93%), Postives = 104/142 (73.24%), Query Frame = 2

Query:  401 MASELLHAEFTLKRILKNTDSSFVIPGNPNLLCTQLPSHWRINKALVKTFKVFSLLPVADGTQVILSAGNNENVCAELRGNHSQMKNQSAIFQDLRFLGKSGRGKRFNITITMESYPPQVSVYANAIKVTVDGPREPRSNNG 826
            M+  +L AE+TL+R L  +    V+ G+P+LLC++LP HWR NK+L   F+V SL+PV DGT+V+LSAGN E   AEL+   + M+NQ A F DLRFLG+SGRGK FN+TI +E+ PP +  Y++AIKVTVDGPR PR+  G
Sbjct:    1 MSDLMLAAEYTLRRALDESSGDLVVTGSPHLLCSRLPKHWRSNKSLPTPFRVVSLVPVPDGTRVLLSAGNEERPFAELKNAIAVMQNQEARFNDLRFLGRSGRGKSFNVTINVETNPPLIGTYSHAIKVTVDGPRVPRNKYG 142

[Close]

BLAST of runt-2 vs. Ensembl Cavefish
Match: ENSAMXT00000000899.2 (pep primary_assembly:Astyanax_mexicanus-2.0:9:25133550:25206568:-1 gene:ENSAMXG00000000881.2 transcript:ENSAMXT00000000899.2 gene_biotype:protein_coding transcript_biotype:protein_coding)

HSP 1 Score: 144.821 bits (364), Expect = 1.335e-38
Identity = 72/132 (54.55%), Postives = 89/132 (67.42%), Query Frame = 2

Query:  419 HAEFTLKRILKNTDSSFVIPGNPNLLCTQLPSHWRINKALVKTFKVFSLLPVADGTQVILSAGNNENVCAELRGNHSQMKNQSAIFQDLRFLGKSGRGKRFNITITMESYPPQVSVYANAIKVTVDGPREPR 814
            H   ++  I+ +  +  V   +PN LC+ LPSHWR NK L   FKV +L  V DGT V + AGN+EN  AELR   + MKNQ A F DLRF+G+SGRGK F +TIT+ + PPQV+ Y  AIKVTVDGPREPR
Sbjct:   62 HDNRSMVEIIADHPAELVRTDSPNFLCSVLPSHWRCNKTLPVAFKVVALGDVPDGTVVTVMAGNDENYSAELRNASAVMKNQVARFNDLRFVGRSGRGKSFTLTITVFTNPPQVATYHRAIKVTVDGPREPR 193

[Close]

BLAST of runt-2 vs. Ensembl Cavefish
Match: runx2b (runt-related transcription factor 2 [Source:NCBI gene;Acc:103028241])

HSP 1 Score: 144.436 bits (363), Expect = 1.715e-38
Identity = 71/128 (55.47%), Postives = 87/128 (67.97%), Query Frame = 2

Query:  431 TLKRILKNTDSSFVIPGNPNLLCTQLPSHWRINKALVKTFKVFSLLPVADGTQVILSAGNNENVCAELRGNHSQMKNQSAIFQDLRFLGKSGRGKRFNITITMESYPPQVSVYANAIKVTVDGPREPR 814
            ++  I+ +  +  V   +PN LC+ LPSHWR NK L   FKV +L  V DGT V + AGN+EN  AELR     MKNQ A F DLRF+G+SGRGK F +TIT+ + PPQV+ Y  AIKVTVDGPREPR
Sbjct:   63 SMAEIIADHPAELVRTDSPNFLCSVLPSHWRCNKTLPVAFKVVALGEVPDGTVVTVMAGNDENYSAELRNASGVMKNQVARFNDLRFVGRSGRGKSFTLTITVFTNPPQVATYHRAIKVTVDGPREPR 190

[Close]

BLAST of runt-2 vs. Ensembl Cavefish
Match: runx2b (runt-related transcription factor 2 [Source:NCBI gene;Acc:103028241])

HSP 1 Score: 144.436 bits (363), Expect = 1.957e-38
Identity = 71/128 (55.47%), Postives = 87/128 (67.97%), Query Frame = 2

Query:  431 TLKRILKNTDSSFVIPGNPNLLCTQLPSHWRINKALVKTFKVFSLLPVADGTQVILSAGNNENVCAELRGNHSQMKNQSAIFQDLRFLGKSGRGKRFNITITMESYPPQVSVYANAIKVTVDGPREPR 814
            ++  I+ +  +  V   +PN LC+ LPSHWR NK L   FKV +L  V DGT V + AGN+EN  AELR     MKNQ A F DLRF+G+SGRGK F +TIT+ + PPQV+ Y  AIKVTVDGPREPR
Sbjct:   25 SMAEIIADHPAELVRTDSPNFLCSVLPSHWRCNKTLPVAFKVVALGEVPDGTVVTVMAGNDENYSAELRNASGVMKNQVARFNDLRFVGRSGRGKSFTLTITVFTNPPQVATYHRAIKVTVDGPREPR 152

[Close]

BLAST of runt-2 vs. Ensembl Cavefish
Match: runx3 (runt-related transcription factor 3 [Source:NCBI gene;Acc:103041531])

HSP 1 Score: 144.05 bits (362), Expect = 3.101e-38
Identity = 71/124 (57.26%), Postives = 85/124 (68.55%), Query Frame = 2

Query:  443 ILKNTDSSFVIPGNPNLLCTQLPSHWRINKALVKTFKVFSLLPVADGTQVILSAGNNENVCAELRGNHSQMKNQSAIFQDLRFLGKSGRGKRFNITITMESYPPQVSVYANAIKVTVDGPREPR 814
            +L +     V   +PN LC+ LPSHWR NK L   FKV +L  V DGT V + AGN+EN  AELR   + MKNQ A F DLRF+G+SGRGK F +TIT+ + PPQV+ Y  AIKVTVDGPREPR
Sbjct:   77 VLADHAGELVRTDSPNFLCSVLPSHWRCNKTLPVAFKVVALGDVPDGTLVTVMAGNDENYSAELRNASAVMKNQVARFNDLRFVGRSGRGKSFTLTITVFTGPPQVATYHRAIKVTVDGPREPR 200

[Close]

BLAST of runt-2 vs. Ensembl Cavefish
Match: runx2b (runt-related transcription factor 2 [Source:NCBI gene;Acc:103028241])

HSP 1 Score: 144.436 bits (363), Expect = 4.326e-38
Identity = 71/128 (55.47%), Postives = 87/128 (67.97%), Query Frame = 2

Query:  431 TLKRILKNTDSSFVIPGNPNLLCTQLPSHWRINKALVKTFKVFSLLPVADGTQVILSAGNNENVCAELRGNHSQMKNQSAIFQDLRFLGKSGRGKRFNITITMESYPPQVSVYANAIKVTVDGPREPR 814
            ++  I+ +  +  V   +PN LC+ LPSHWR NK L   FKV +L  V DGT V + AGN+EN  AELR     MKNQ A F DLRF+G+SGRGK F +TIT+ + PPQV+ Y  AIKVTVDGPREPR
Sbjct:   63 SMAEIIADHPAELVRTDSPNFLCSVLPSHWRCNKTLPVAFKVVALGEVPDGTVVTVMAGNDENYSAELRNASGVMKNQVARFNDLRFVGRSGRGKSFTLTITVFTNPPQVATYHRAIKVTVDGPREPR 190

[Close]

BLAST of runt-2 vs. Ensembl Nematostella
Match: EDO33538 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7SRX2])

HSP 1 Score: 147.902 bits (372), Expect = 3.997e-43
Identity = 75/148 (50.68%), Postives = 96/148 (64.86%), Query Frame = 2

Query:  374 LTRIENKYCMASELLHAEFTLKRILKNTDSSFVIPGNPNLLCTQLPSHWRINKALVKTFKVFSLLPVADGTQVILSAGNNENVCAELRGNHSQMKNQSAIFQDLRFLGKSGRGKRFNITITMESYPPQVSVYANAIKVTVDGPREPRS 817
            +T  EN+    +  +  E +L   L       V   +PN +C+ LPSHWR NK L   FKV SL  + DG  V ++AGN+EN  AELR   + MKNQ A F DLRF+G+SGRGK F++TIT+++ PPQV+ Y  AIKVTVDGPREPRS
Sbjct:    1 MTTTENQ---GTRKIKGERSLVEALAEYPGELVKTDSPNFVCSVLPSHWRCNKTLPVAFKVVSLGDIPDGVIVSIAAGNDENFAAELRNATAVMKNQVARFNDLRFVGRSGRGKTFSLTITVKTEPPQVATYCRAIKVTVDGPREPRS 145

[Close]

BLAST of runt-2 vs. Ensembl Medaka
Match: runx2 (RUNX family transcription factor 2 [Source:NCBI gene;Acc:100049495])

HSP 1 Score: 144.821 bits (364), Expect = 1.235e-38
Identity = 71/132 (53.79%), Postives = 88/132 (66.67%), Query Frame = 2

Query:  419 HAEFTLKRILKNTDSSFVIPGNPNLLCTQLPSHWRINKALVKTFKVFSLLPVADGTQVILSAGNNENVCAELRGNHSQMKNQSAIFQDLRFLGKSGRGKRFNITITMESYPPQVSVYANAIKVTVDGPREPR 814
            H   ++  I+ +  +  V   +PN LC+ LPSHWR NK L   FKV +L  + DGT V + AGN+EN  AELR     MKNQ A F DLRF+G+SGRGK F +TIT+ + PPQV+ Y  AIKVTVDGPREPR
Sbjct:   23 HENRSMAEIIADHPAELVRTDSPNFLCSVLPSHWRCNKTLPVAFKVVALGDIPDGTVVTVMAGNDENYSAELRNASGVMKNQVARFNDLRFVGRSGRGKSFTLTITVFTNPPQVATYHRAIKVTVDGPREPR 154

[Close]

BLAST of runt-2 vs. Ensembl Medaka
Match: runx3 (runt-related transcription factor 3 [Source:NCBI gene;Acc:101160370])

HSP 1 Score: 143.28 bits (360), Expect = 1.976e-38
Identity = 86/196 (43.88%), Postives = 109/196 (55.61%), Query Frame = 2

Query:  443 ILKNTDSSFVIPGNPNLLCTQLPSHWRINKALVKTFKVFSLLPVADGTQVILSAGNNENVCAELRGNHSQMKNQSAIFQDLRFLGKSGRGKRFNITITMESYPPQVSVYANAIKVTVDGPREPRSNNGSSLKVNKPIR-------------QSPCKF-PTYSSPVIEKQLLLDVIQQTADI--RRLNLKRLHPLSD 982
            +L +     V   +PN LC+ LPSHWR NK L   FKV +L  V DGT V + AGN+EN  AELR   + MKNQ A F DLRF+G+SGRGK F +TIT+ + PPQV+ Y  AIKVTVDGPREPR +    +K+  P +             Q   +  P  ++P    Q  L   Q T D   +R     L PL+D
Sbjct:   50 VLADHAGELVRTDSPNFLCSVLPSHWRCNKTLPVAFKVVALGDVPDGTLVTVMAGNDENYSAELRNASAVMKNQVARFNDLRFVGRSGRGKSFTLTITVFTGPPQVATYHRAIKVTVDGPREPRRHR---VKIEDPQKMQFSDRLSEIERYQRTMRIGPVNNNPRPIHQTHLSTTQATTDFFPQRTTFPSLSPLTD 242

[Close]

BLAST of runt-2 vs. Ensembl Medaka
Match: runx3 (runt-related transcription factor 3 [Source:NCBI gene;Acc:101160370])

HSP 1 Score: 143.28 bits (360), Expect = 1.984e-38
Identity = 71/125 (56.80%), Postives = 86/125 (68.80%), Query Frame = 2

Query:  443 ILKNTDSSFVIPGNPNLLCTQLPSHWRINKALVKTFKVFSLLPVADGTQVILSAGNNENVCAELRGNHSQMKNQSAIFQDLRFLGKSGRGKRFNITITMESYPPQVSVYANAIKVTVDGPREPRS 817
            +L +     V   +PN LC+ LPSHWR NK L   FKV +L  V DGT V + AGN+EN  AELR   + MKNQ A F DLRF+G+SGRGK F +TIT+ + PPQV+ Y  AIKVTVDGPREPR+
Sbjct:   64 VLADHAGELVRTDSPNFLCSVLPSHWRCNKTLPVAFKVVALGDVPDGTLVTVMAGNDENYSAELRNASAVMKNQVARFNDLRFVGRSGRGKSFTLTITVFTGPPQVATYHRAIKVTVDGPREPRT 188

[Close]

BLAST of runt-2 vs. Ensembl Medaka
Match: runx2 (RUNX family transcription factor 2 [Source:NCBI gene;Acc:100049495])

HSP 1 Score: 144.821 bits (364), Expect = 3.002e-38
Identity = 71/132 (53.79%), Postives = 88/132 (66.67%), Query Frame = 2

Query:  419 HAEFTLKRILKNTDSSFVIPGNPNLLCTQLPSHWRINKALVKTFKVFSLLPVADGTQVILSAGNNENVCAELRGNHSQMKNQSAIFQDLRFLGKSGRGKRFNITITMESYPPQVSVYANAIKVTVDGPREPR 814
            H   ++  I+ +  +  V   +PN LC+ LPSHWR NK L   FKV +L  + DGT V + AGN+EN  AELR     MKNQ A F DLRF+G+SGRGK F +TIT+ + PPQV+ Y  AIKVTVDGPREPR
Sbjct:   63 HENRSMAEIIADHPAELVRTDSPNFLCSVLPSHWRCNKTLPVAFKVVALGDIPDGTVVTVMAGNDENYSAELRNASGVMKNQVARFNDLRFVGRSGRGKSFTLTITVFTNPPQVATYHRAIKVTVDGPREPR 194

[Close]

BLAST of runt-2 vs. Ensembl Medaka
Match: runx3 (runt-related transcription factor 3 [Source:NCBI gene;Acc:101160370])

HSP 1 Score: 142.895 bits (359), Expect = 6.105e-38
Identity = 71/124 (57.26%), Postives = 85/124 (68.55%), Query Frame = 2

Query:  443 ILKNTDSSFVIPGNPNLLCTQLPSHWRINKALVKTFKVFSLLPVADGTQVILSAGNNENVCAELRGNHSQMKNQSAIFQDLRFLGKSGRGKRFNITITMESYPPQVSVYANAIKVTVDGPREPR 814
            +L +     V   +PN LC+ LPSHWR NK L   FKV +L  V DGT V + AGN+EN  AELR   + MKNQ A F DLRF+G+SGRGK F +TIT+ + PPQV+ Y  AIKVTVDGPREPR
Sbjct:   64 VLADHAGELVRTDSPNFLCSVLPSHWRCNKTLPVAFKVVALGDVPDGTLVTVMAGNDENYSAELRNASAVMKNQVARFNDLRFVGRSGRGKSFTLTITVFTGPPQVATYHRAIKVTVDGPREPR 187

[Close]

BLAST of runt-2 vs. Planmine SMEST
Match: SMESG000049171.1 (SMESG000049171.1)

HSP 1 Score: 462.225 bits (1188), Expect = 9.763e-165
Identity = 224/224 (100.00%), Postives = 224/224 (100.00%), Query Frame = 2

Query:  401 MASELLHAEFTLKRILKNTDSSFVIPGNPNLLCTQLPSHWRINKALVKTFKVFSLLPVADGTQVILSAGNNENVCAELRGNHSQMKNQSAIFQDLRFLGKSGRGKRFNITITMESYPPQVSVYANAIKVTVDGPREPRSNNGSSLKVNKPIRQSPCKFPTYSSPVIEKQLLLDVIQQTADIRRLNLKRLHPLSDTDIEKFINDVYKRRKKCLSLSLMTSIDERE 1072
            MASELLHAEFTLKRILKNTDSSFVIPGNPNLLCTQLPSHWRINKALVKTFKVFSLLPVADGTQVILSAGNNENVCAELRGNHSQMKNQSAIFQDLRFLGKSGRGKRFNITITMESYPPQVSVYANAIKVTVDGPREPRSNNGSSLKVNKPIRQSPCKFPTYSSPVIEKQLLLDVIQQTADIRRLNLKRLHPLSDTDIEKFINDVYKRRKKCLSLSLMTSIDERE
Sbjct:    1 MASELLHAEFTLKRILKNTDSSFVIPGNPNLLCTQLPSHWRINKALVKTFKVFSLLPVADGTQVILSAGNNENVCAELRGNHSQMKNQSAIFQDLRFLGKSGRGKRFNITITMESYPPQVSVYANAIKVTVDGPREPRSNNGSSLKVNKPIRQSPCKFPTYSSPVIEKQLLLDVIQQTADIRRLNLKRLHPLSDTDIEKFINDVYKRRKKCLSLSLMTSIDERE 224

[Close]

BLAST of runt-2 vs. Planmine SMEST
Match: SMESG000014779.1 (SMESG000014779.1)

HSP 1 Score: 114.39 bits (285), Expect = 1.100e-28
Identity = 59/122 (48.36%), Postives = 78/122 (63.93%), Query Frame = 2

Query:  470 VIP-GNPNLLCTQLPSHWRINKALVKTFKVF------SLLPVADGTQVILSAGNNENVCAELRGNHSQMKNQSAIFQDLRFLGKSGRGKRFNITITMESYPPQVSVYANAIKVTVDGPREPR 814
            ++P  +P + CT+LP HWR NK+L   F+V        +LP+ DG +V LSA N     A LR   S++ N  A F DLRF+ +SGRGK F++ I +E  P  ++VY NAIKVTVDGPREPR
Sbjct:   29 IVPTSHPLVFCTKLPQHWRSNKSLPALFQVMVYQSNNRVLPIGDGHRVWLSASNPSMNSAVLRNFESKLVNGEARFNDLRFISRSGRGKYFDVYIHIECNPKIIAVYTNAIKVTVDGPREPR 150

The following BLAST results are available for this feature:

BLAST of runt-2 vs. Ensembl Human
BLAST of runt-2 vs. Ensembl Celegans
BLAST of runt-2 vs. Ensembl Fly
BLAST of runt-2 vs. Ensembl Zebrafish
BLAST of runt-2 vs. Ensembl Xenopus
BLAST of runt-2 vs. Ensembl Mouse
BLAST of runt-2 vs. UniProt/SwissProt
BLAST of runt-2 vs. TrEMBL
BLAST of runt-2 vs. Ensembl Cavefish
BLAST of runt-2 vs. Ensembl Sea Lamprey
BLAST of runt-2 vs. Ensembl Yeast
BLAST of runt-2 vs. Ensembl Nematostella
BLAST of runt-2 vs. Ensembl Medaka
BLAST of runt-2 vs. Planmine SMEST

BLAST of runt-2 vs. Ensembl Human
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Human e!99)
Total hits: 5


Match Name	E-value	Identity	Description
RUNX2	1.045e-40	55.30	RUNX family transcription factor 2 [Source:HGNC Sy...	[more]
RUNX1	1.532e-40	51.08	RUNX family transcription factor 1 [Source:HGNC Sy...	[more]
RUNX1	1.603e-40	51.08	RUNX family transcription factor 1 [Source:HGNC Sy...	[more]
RUNX2	5.520e-40	55.30	RUNX family transcription factor 2 [Source:HGNC Sy...	[more]
RUNX1	5.006e-39	51.08	RUNX family transcription factor 1 [Source:HGNC Sy...	[more]

BLAST of runt-2 vs. Ensembl Celegans
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99)
Total hits: 2


Match Name	E-value	Identity	Description
rnt-1	1.501e-30	49.11	RNT-1; RuNT related; Transcription factor RUN [So...	[more]
rnt-1	1.501e-30	49.11	RNT-1; RuNT related; Transcription factor RUN [So...	[more]

BLAST of runt-2 vs. Ensembl Fly
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99)
Total hits: 5


Match Name	E-value	Identity	Description
lz	2.404e-41	45.16	gene:FBgn0002576 transcript:FBtr0071320	[more]
lz	5.543e-41	55.15	gene:FBgn0002576 transcript:FBtr0112814	[more]
run	3.334e-40	50.00	gene:FBgn0003300 transcript:FBtr0345922	[more]
run	3.334e-40	50.00	gene:FBgn0003300 transcript:FBtr0077279	[more]
run	3.499e-40	50.00	gene:FBgn0003300 transcript:FBtr0304593	[more]

BLAST of runt-2 vs. Ensembl Zebrafish
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99)
Total hits: 5


Match Name	E-value	Identity	Description
runx2a	6.193e-41	55.30	RUNX family transcription factor 2a [Source:ZFIN;A...	[more]
runx2a	5.181e-39	55.30	RUNX family transcription factor 2a [Source:ZFIN;A...	[more]
runx2a	7.614e-39	55.30	RUNX family transcription factor 2a [Source:ZFIN;A...	[more]
runx3	3.249e-38	53.24	RUNX family transcription factor 3 [Source:ZFIN;Ac...	[more]
runx3	3.249e-38	53.24	RUNX family transcription factor 3 [Source:ZFIN;Ac...	[more]

BLAST of runt-2 vs. Ensembl Xenopus
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99)
Total hits: 5


Match Name	E-value	Identity	Description
taf4	7.786e-39	45.13	TATA-box binding protein associated factor 4 [Sour...	[more]
znf385d	3.244e-38	48.30	zinc finger protein 385D [Source:Xenbase;Acc:XB-GE...	[more]
taf4	4.983e-38	55.47	TATA-box binding protein associated factor 4 [Sour...	[more]
taf4	8.048e-38	55.47	TATA-box binding protein associated factor 4 [Sour...	[more]
znf385d	1.155e-37	48.95	zinc finger protein 385D [Source:Xenbase;Acc:XB-GE...	[more]

BLAST of runt-2 vs. Ensembl Mouse
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99)
Total hits: 5


Match Name	E-value	Identity	Description
Runx2	6.957e-41	56.25	runt related transcription factor 2 [Source:MGI Sy...	[more]
Runx2	1.014e-40	55.30	runt related transcription factor 2 [Source:MGI Sy...	[more]
Runx1	8.703e-40	49.66	runt related transcription factor 1 [Source:MGI Sy...	[more]
Runx1	2.714e-39	50.35	runt related transcription factor 1 [Source:MGI Sy...	[more]
Runx1	3.883e-39	49.66	runt related transcription factor 1 [Source:MGI Sy...	[more]

BLAST of runt-2 vs. UniProt/SwissProt
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt)
Total hits: 5


Match Name	E-value	Identity	Description
sp\|Q9W349\|LOZEN_DROME	2.410e-40	45.16	Protein lozenge OS=Drosophila melanogaster OX=7227...	[more]
sp\|P22814\|RUNT_DROME	3.342e-39	50.00	Segmentation protein Runt OS=Drosophila melanogast...	[more]
sp\|Q63046\|RUNX1_RAT	1.793e-38	50.35	Runt-related transcription factor 1 OS=Rattus norv...	[more]
sp\|Q03347\|RUNX1_MOUSE	1.918e-38	51.80	Runt-related transcription factor 1 OS=Mus musculu...	[more]
sp\|Q01196\|RUNX1_HUMAN	6.558e-38	51.08	Runt-related transcription factor 1 OS=Homo sapien...	[more]

BLAST of runt-2 vs. TrEMBL
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL)
Total hits: 5


Match Name	E-value	Identity	Description
I1ZI66	2.069e-97	97.95	Runt-2 OS=Schmidtea mediterranea OX=79327 PE=2 SV=...	[more]
A0A1L7H9X8	3.126e-93	93.15	Transcriptional regulatory protein Runt-2 OS=Duges...	[more]
A0A183SL26	4.435e-48	53.80	Runt domain-containing protein OS=Schistocephalus ...	[more]
W6US52	4.754e-47	57.04	Runt-related transcription factor OS=Echinococcus ...	[more]
A0A0R3TQC1	6.561e-46	54.93	Runt domain-containing protein OS=Rodentolepis nan...	[more]

BLAST of runt-2 vs. Ensembl Cavefish
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99)
Total hits: 5


Match Name	E-value	Identity	Description
ENSAMXT00000000899.2	1.335e-38	54.55	pep primary_assembly:Astyanax_mexicanus-2.0:9:2513...	[more]
runx2b	1.715e-38	55.47	runt-related transcription factor 2 [Source:NCBI g...	[more]
runx2b	1.957e-38	55.47	runt-related transcription factor 2 [Source:NCBI g...	[more]
runx3	3.101e-38	57.26	runt-related transcription factor 3 [Source:NCBI g...	[more]
runx2b	4.326e-38	55.47	runt-related transcription factor 2 [Source:NCBI g...	[more]

BLAST of runt-2 vs. Ensembl Sea Lamprey
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99)
Total hits: 0


Match Name	E-value	Identity	Description

BLAST of runt-2 vs. Ensembl Yeast
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46)
Total hits: 0


Match Name	E-value	Identity	Description

BLAST of runt-2 vs. Ensembl Nematostella
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46)
Total hits: 1


Match Name	E-value	Identity	Description
EDO33538	3.997e-43	50.68	Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7...	[more]

BLAST of runt-2 vs. Ensembl Medaka
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99)
Total hits: 5


Match Name	E-value	Identity	Description
runx2	1.235e-38	53.79	RUNX family transcription factor 2 [Source:NCBI ge...	[more]
runx3	1.976e-38	43.88	runt-related transcription factor 3 [Source:NCBI g...	[more]
runx3	1.984e-38	56.80	runt-related transcription factor 3 [Source:NCBI g...	[more]
runx2	3.002e-38	53.79	RUNX family transcription factor 2 [Source:NCBI ge...	[more]
runx3	6.105e-38	57.26	runt-related transcription factor 3 [Source:NCBI g...	[more]

BLAST of runt-2 vs. Planmine SMEST
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST)
Total hits: 2


Match Name	E-value	Identity	Description
SMESG000049171.1	9.763e-165	100.00	SMESG000049171.1	[more]
SMESG000014779.1	1.100e-28	48.36	SMESG000014779.1	[more]

Analyses

This transcript is derived from or has results from the following analyses


Analysis Name	Date Performed
Embryonic Stages	2016-07-25
Schmidtea mediterranea smed_20140614 BLASTX Human e!99	2016-08-08
Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99	2016-08-08
Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL	2020-05-01
Schmidtea mediterranea Sexual smed_20140614 transcriptome	2016-07-25
Schmidtea mediteranean smed_20140614 Interproscan	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST	2020-05-08

Cross References

External references for this transcript


Database	Accession
SmedGD GBrowse	SMED30013043
GenBank	AFJ24720.1

Sequences

The following sequences are available for this feature:

transcript sequence
protein sequence

transcript sequence

>SMED30013043 ID=SMED30013043|Name=runt-2|organism=Schmidtea mediterranea sexual|type=transcript|length=1281bp
GCAGCCATGAGTCAGTTATGTAGTCATGCTTGTATGCGTGGGTGTATCAT
ACGAATCGTTGGCATTAGTCTATTTGTAGATTTTGATTCTCGTTGATTAT
TGGTTTTATAAATTCAATCTACAGCTCAATAAATACATTTATTCGCATTC
GCATTAGTATTAGGTCAATACGAGGTTACTGTATCTAGGCTGTGACAATA
TAGATTCATTATATATATACACACACTGACATACACACATAGACATATAC
ACAACTGTTCTGTTGTTGTCATCATTGTACTCGTGTCGCTGTTGTACTAG
ATTATCATCCGGCTGACCAGCATTTATAAATACTCCAATATTTTCATTAT
TCTCGGAATCAACCACAAAAGTGCTAACAAGAATCGAGAACAAATACTGC
ATGGCATCGGAATTGCTACATGCCGAGTTTACGCTGAAGAGGATTTTGAA
AAATACTGACTCGAGCTTTGTCATTCCTGGCAATCCGAACCTTTTATGCA
CCCAGTTGCCGTCTCATTGGAGAATCAACAAGGCGTTGGTGAAAACGTTT
AAAGTCTTTTCGTTGTTGCCGGTTGCCGATGGGACCCAGGTAATTCTATC
TGCTGGAAACAATGAGAATGTCTGTGCTGAATTACGCGGCAATCATTCAC
AGATGAAGAATCAATCTGCGATCTTTCAGGATTTGCGATTTCTCGGGAAA
AGTGGACGAGGAAAGCGGTTCAATATCACAATCACAATGGAATCCTATCC
GCCGCAGGTGTCAGTGTATGCTAACGCGATCAAGGTGACAGTTGATGGGC
CGCGGGAACCCAGATCAAATAATGGAAGTTCATTGAAAGTTAATAAGCCT
ATTCGTCAATCTCCGTGTAAATTTCCCACATATAGTTCTCCTGTTATTGA
AAAGCAGCTCCTTTTGGACGTCATTCAGCAGACCGCCGACATACGGAGGC
TCAATTTAAAACGACTTCATCCGTTATCAGACACAGATATTGAAAAATTT
ATTAATGATGTGTACAAACGTCGAAAGAAATGTCTTTCTTTATCTCTGAT
GACCTCGATAGACGAGAGGGAATGATTAAGAATTGAGAATTGCAATGAGC
ATATAATAGATATATTTGCAGCCCCATATTAGCTCATTCAAATGAATCAC
ATTACCAAAGAGCTTTCAAAAAGAACTGCATAAAGATGTCAATGGTGATG
CCAATGCTGTAGATAAGATAGAGCAGTTTCTATGCCAAAGGTGTTGAGGC
TCAAATAACTATTGATATTTTCATATTACCG

protein sequence of SMED30013043-orf-1

>SMED30013043-orf-1 ID=SMED30013043-orf-1|Name=SMED30013043-orf-1|organism=Schmidtea mediterranea sexual|type=polypeptide|length=225bp
MASELLHAEFTLKRILKNTDSSFVIPGNPNLLCTQLPSHWRINKALVKTF
KVFSLLPVADGTQVILSAGNNENVCAELRGNHSQMKNQSAIFQDLRFLGK
SGRGKRFNITITMESYPPQVSVYANAIKVTVDGPREPRSNNGSSLKVNKP
IRQSPCKFPTYSSPVIEKQLLLDVIQQTADIRRLNLKRLHPLSDTDIEKF
INDVYKRRKKCLSLSLMTSIDERE*

Annotated Terms

The following terms have been associated with this transcript:

Vocabulary: **Planarian Anatomy**
Term	Definition
PLANA:0000026	gut
PLANA:0000034	epidermis
PLANA:0000070	intestinal phagocyte
PLANA:0003116	parenchymal cell

Vocabulary: **INTERPRO**
Term	Definition
IPR000040	AML1_Runt
IPR012346	p53/RUNT-type_TF_DNA-bd_sf
IPR013524	Runt_dom
IPR008967	p53-like_TF_DNA-bd

Vocabulary: **biological process**
Term	Definition
GO:0006355	regulation of transcription, DNA-templated

Vocabulary: **cellular component**
Term	Definition
GO:0005634	nucleus

Vocabulary: **molecular function**
Term	Definition
GO:0005524	ATP binding
GO:0003677	DNA binding
GO:0003700	transcription factor activity, sequence-specific DNA binding

InterPro

Analysis Name: Schmidtea mediteranean smed_20140614 Interproscan
Date Performed: 2020-05-01


IPR Term	IPR Description	Source	Source Term	Source Description	Alignment
IPR000040	Acute myeloid leukemia 1 protein (AML1)/Runt	PRINTS	PR00967	ONCOGENEAML1	coord: 51..70 score: 55.0 coord: 29..50 score: 61.57 coord: 71..92 score: 54.13 coord: 93..114 score: 63.64 coord: 115..137 score: 71.15
IPR000040	Acute myeloid leukemia 1 protein (AML1)/Runt	PANTHER	PTHR11950	RUNT RELATED	coord: 4..156
IPR013524	Runt domain	PFAM	PF00853	Runt	coord: 13..140 e-value: 5.6E-51 score: 171.5
IPR013524	Runt domain	PROSITE	PS51062	RUNT	coord: 11..139 score: 50.563
IPR012346	p53/RUNT-type transcription factor, DNA-binding domain superfamily	GENE3D	G3DSA:2.60.40.720		coord: 9..150 e-value: 7.3E-56 score: 189.2
None	No IPR available	PANTHER	PTHR11950:SF31	PROTEIN LOZENGE-RELATED	coord: 4..156
IPR008967	p53-like transcription factor, DNA-binding	SUPERFAMILY	SSF49417	p53-like transcription factors	coord: 16..139

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runt-2

Zeng et. al., 2018

▻ Overview

▻ Neoblast Population

▻ Sub-lethal Irradiated Surviving X1 and X2 Cell Population

Overview

Single cell RNA-seq of pluripotent neoblasts and its early progenies

Explore this single cell expression dataset with our NB Cluster Shiny App

Neoblast Population

Sub-lethal Irradiated Surviving X1 and X2 Cell Population

Davies et. al., 2017

PAGE et. al., 2020

has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGE

PAGE Curations: 12

Owlery

blazegraph-runner