runt-2

Overview
Namerunt-2 (AFJ24720.1)
Smed IDSMED30013043
Length (bp)1281
Neoblast Clusters

Zeng et. al., 2018




▻ Overview

▻ Neoblast Population

▻ Sub-lethal Irradiated Surviving X1 and X2 Cell Population

 



 

Overview

 

Single cell RNA-seq of pluripotent neoblasts and its early progenies


We isolated X1 neoblasts cells enriched in high piwi-1 expression (Neoblast Population), and profiled ∼7,614 individual cells via scRNA-seq. Unsupervised analyses uncovered 12 distinct classes from 7,088 high-quality cells. We designated these classes Nb1 to Nb12 and ordered them based on high (Nb1) to low (Nb12) piwi-1 expression levels. We further defined groups of genes that best classified the cells parsed into 12 distinct cell clusters to generate a scaled expression heat map of discriminative gene sets for each cluster. Expression of each cluster’s gene signatures was validated using multiplex fluorescence in situ hybridization (FISH) co-stained with piwi-1 and largely confirmed the cell clusters revealed by scRNA-seq.

We also tested sub-lethal irradiation exposure. To profile rare pluripotent stem cells (PSCs) and avoid interference from immediate progenitor cells, we determined a time point after sub-lethal irradiation (7 DPI) with minimal piwi-1+ cells, followed by isolation and single-cell RNA-seq of 1,200 individual cells derived from X1 (Piwi-1 high) and X2 (Piwi-1 low) cell populations (Sub-lethal Irradiated Surviving X1 and X2 Cell Population)




Explore this single cell expression dataset with our NB Cluster Shiny App




 

Neoblast Population

 

t-SNE plot shows two-dimensional representation of global gene expression relationships among all neoblasts (n = 7,088 after filter). Cluster identity was assigned based on the top 10 marker genes of each cluster (Table S2), followed by inspection of RNA in situ hybridization patterns. Neoblast groups, Nb.


Expression of runt-2 (SMED30013043) t-SNE clustered cells

Violin plots show distribution of expression levels for runt-2 (SMED30013043) in cells (dots) of each of the 12 neoblast clusters.

 

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Sub-lethal Irradiated Surviving X1 and X2 Cell Population

 

t-SNE plot of surviving X1 and X2 cells (n = 1,039 after QC filter) after sub-lethal irradiation. Colors indicate unbiased cell classification via graph-based clustering. SL, sub-lethal irradiated cell groups.

Expression of runt-2 (SMED30013043) in the t-SNE clustered sub-lethally irradiated X1 and X2 cells.

Violin plots show distribution of expression levels for runt-2 (SMED30013043) in cells (dots) of each of the 10 clusters of sub-leathally irradiated X1 and X2 cells.

 

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Embryonic Expression

Davies et. al., 2017




Hover the mouse over a column in the graph to view average RPKM values per sample.
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Embryonic Stages: Y: yolk. S2-S8: Stages 2-8. C4: asexual adult. SX: virgin, sexually mature adult.
For further information about sample preparation and analysis for the single animal RNA-Seq experiment, please refer to the Materials and Methods

 

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Anatomical Expression

PAGE et. al., 2020




SMED30013043

has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGE



PAGE Curations: 12

  
Expressed InReference TranscriptGene ModelsPublished TranscriptTranscriptomePublicationSpecimenLifecycleEvidence
intestinal phagocyteSMED30013043h1SMcG0016472 Contig3856newmark_estsPMID:23079596
Forsthoefel et al., 2012
FACS sorted cell population asexual adult cDNA to DNA expression microarray evidence
intestinal phagocyteSMED30013043h1SMcG0016472 Contig3856uc_Smed_v2PMID:23079596
Forsthoefel et al., 2012
FACS sorted cell population asexual adult cDNA to DNA expression microarray evidence
intestinal phagocyteSMED30013043h1SMcG0015526 Contig3856newmark_estsPMID:23079596
Forsthoefel et al., 2012
FACS sorted cell population asexual adult cDNA to DNA expression microarray evidence
intestinal phagocyteSMED30013043h1SMcG0015526 Contig3856uc_Smed_v2PMID:23079596
Forsthoefel et al., 2012
FACS sorted cell population asexual adult cDNA to DNA expression microarray evidence
nervous systemSMED30013043h1SMcG0016472 dd_Smed_v4_3565_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018
FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
gutSMED30013043h1SMcG0016472 dd_Smed_v4_3565_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018
FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
epidermisSMED30013043h1SMcG0016472 dd_Smed_v4_3565_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018
FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
cephalic gangliaSMED30013043h1SMcG0016472 dd_Smed_v4_3565_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018
FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
neoblastSMED30013043h1SMcG0016472 dd_Smed_v4_3565_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018
FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
parenchymal cellSMED30013043h1SMcG0016472 dd_Smed_v4_3565_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018
FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
non-ciliated neuronSMED30013043h1SMcG0016472 dd_Smed_v4_3565_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018
FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
epidermisSMED30013043h1SMcG0016472 dd_Smed_v4_3565_0_1dd_Smed_v4PMID:28292427
Wurtzel et al., 2017
whole organism asexual adult single-cell RNA-sequencing evidence
Note: Hover over icons to view figure legend
Homology
BLAST of runt-2 vs. Ensembl Human
Match: RUNX2 (RUNX family transcription factor 2 [Source:HGNC Symbol;Acc:HGNC:10472])

HSP 1 Score: 147.517 bits (371), Expect = 1.045e-40
Identity = 73/132 (55.30%), Postives = 89/132 (67.42%), Query Frame = 2
Query:  419 HAEFTLKRILKNTDSSFVIPGNPNLLCTQLPSHWRINKALVKTFKVFSLLPVADGTQVILSAGNNENVCAELRGNHSQMKNQSAIFQDLRFLGKSGRGKRFNITITMESYPPQVSVYANAIKVTVDGPREPR 814
            H   T+  I+ +  +  V   +PN LC+ LPSHWR NK L   FKV +L  V DGT V + AGN+EN  AELR   + MKNQ A F DLRF+G+SGRGK F +TIT+ + PPQV+ Y  AIKVTVDGPREPR
Sbjct:   83 HDNRTMVEIIADHPAELVRTDSPNFLCSVLPSHWRCNKTLPVAFKVVALGEVPDGTVVTVMAGNDENYSAELRNASAVMKNQVARFNDLRFVGRSGRGKSFTLTITVFTNPPQVATYHRAIKVTVDGPREPR 214          
BLAST of runt-2 vs. Ensembl Human
Match: RUNX1 (RUNX family transcription factor 1 [Source:HGNC Symbol;Acc:HGNC:10471])

HSP 1 Score: 146.362 bits (368), Expect = 1.532e-40
Identity = 71/139 (51.08%), Postives = 92/139 (66.19%), Query Frame = 2
Query:  398 CMASELLHAEFTLKRILKNTDSSFVIPGNPNLLCTQLPSHWRINKALVKTFKVFSLLPVADGTQVILSAGNNENVCAELRGNHSQMKNQSAIFQDLRFLGKSGRGKRFNITITMESYPPQVSVYANAIKVTVDGPREPR 814
             +A +L   + ++  +L +     V   +PN LC+ LP+HWR NK L   FKV +L  V DGT V + AGN+EN  AELR   + MKNQ A F DLRF+G+SGRGK F +TIT+ + PPQV+ Y  AIK+TVDGPREPR
Sbjct:   39 ALAGKLRSGDRSMVEVLADHPGELVRTDSPNFLCSVLPTHWRCNKTLPIAFKVVALGDVPDGTLVTVMAGNDENYSAELRNATAAMKNQVARFNDLRFVGRSGRGKSFTLTITVFTNPPQVATYHRAIKITVDGPREPR 177          
BLAST of runt-2 vs. Ensembl Human
Match: RUNX1 (RUNX family transcription factor 1 [Source:HGNC Symbol;Acc:HGNC:10471])

HSP 1 Score: 146.362 bits (368), Expect = 1.603e-40
Identity = 71/139 (51.08%), Postives = 92/139 (66.19%), Query Frame = 2
Query:  398 CMASELLHAEFTLKRILKNTDSSFVIPGNPNLLCTQLPSHWRINKALVKTFKVFSLLPVADGTQVILSAGNNENVCAELRGNHSQMKNQSAIFQDLRFLGKSGRGKRFNITITMESYPPQVSVYANAIKVTVDGPREPR 814
             +A +L   + ++  +L +     V   +PN LC+ LP+HWR NK L   FKV +L  V DGT V + AGN+EN  AELR   + MKNQ A F DLRF+G+SGRGK F +TIT+ + PPQV+ Y  AIK+TVDGPREPR
Sbjct:   54 ALAGKLRSGDRSMVEVLADHPGELVRTDSPNFLCSVLPTHWRCNKTLPIAFKVVALGDVPDGTLVTVMAGNDENYSAELRNATAAMKNQVARFNDLRFVGRSGRGKSFTLTITVFTNPPQVATYHRAIKITVDGPREPR 192          
BLAST of runt-2 vs. Ensembl Human
Match: RUNX2 (RUNX family transcription factor 2 [Source:HGNC Symbol;Acc:HGNC:10472])

HSP 1 Score: 147.132 bits (370), Expect = 5.520e-40
Identity = 73/132 (55.30%), Postives = 89/132 (67.42%), Query Frame = 2
Query:  419 HAEFTLKRILKNTDSSFVIPGNPNLLCTQLPSHWRINKALVKTFKVFSLLPVADGTQVILSAGNNENVCAELRGNHSQMKNQSAIFQDLRFLGKSGRGKRFNITITMESYPPQVSVYANAIKVTVDGPREPR 814
            H   T+  I+ +  +  V   +PN LC+ LPSHWR NK L   FKV +L  V DGT V + AGN+EN  AELR   + MKNQ A F DLRF+G+SGRGK F +TIT+ + PPQV+ Y  AIKVTVDGPREPR
Sbjct:   83 HDNRTMVEIIADHPAELVRTDSPNFLCSVLPSHWRCNKTLPVAFKVVALGEVPDGTVVTVMAGNDENYSAELRNASAVMKNQVARFNDLRFVGRSGRGKSFTLTITVFTNPPQVATYHRAIKVTVDGPREPR 214          
BLAST of runt-2 vs. Ensembl Human
Match: RUNX1 (RUNX family transcription factor 1 [Source:HGNC Symbol;Acc:HGNC:10471])

HSP 1 Score: 145.976 bits (367), Expect = 5.006e-39
Identity = 71/139 (51.08%), Postives = 92/139 (66.19%), Query Frame = 2
Query:  398 CMASELLHAEFTLKRILKNTDSSFVIPGNPNLLCTQLPSHWRINKALVKTFKVFSLLPVADGTQVILSAGNNENVCAELRGNHSQMKNQSAIFQDLRFLGKSGRGKRFNITITMESYPPQVSVYANAIKVTVDGPREPR 814
             +A +L   + ++  +L +     V   +PN LC+ LP+HWR NK L   FKV +L  V DGT V + AGN+EN  AELR   + MKNQ A F DLRF+G+SGRGK F +TIT+ + PPQV+ Y  AIK+TVDGPREPR
Sbjct:   39 ALAGKLRSGDRSMVEVLADHPGELVRTDSPNFLCSVLPTHWRCNKTLPIAFKVVALGDVPDGTLVTVMAGNDENYSAELRNATAAMKNQVARFNDLRFVGRSGRGKSFTLTITVFTNPPQVATYHRAIKITVDGPREPR 177          
BLAST of runt-2 vs. Ensembl Celegans
Match: rnt-1 (RNT-1; RuNT related; Transcription factor RUN [Source:UniProtKB/TrEMBL;Acc:G5EFQ5])

HSP 1 Score: 119.783 bits (299), Expect = 1.501e-30
Identity = 55/112 (49.11%), Postives = 75/112 (66.96%), Query Frame = 2
Query:  479 GNPNLLCTQLPSHWRINKALVKTFKVFSLLPVADGTQVILSAGNNENVCAELRGNHSQMKNQSAIFQDLRFLGKSGRGKRFNITITMESYPPQVSVYANAIKVTVDGPREPR 814
             +PN+L T LP HWR NK+  + F V  L PV D T+V + AGN+E  C E+R   +++  Q A F DLRF+G+SGRG++F++TI + S P  V+   N IKVTVDGPR+ R
Sbjct:   26 SSPNILYTALPKHWRSNKSFQEPFYVVLLTPVPDNTEVSIWAGNDEKPCEEVRNEKAKVHRQVAKFNDLRFVGRSGRGRKFHLTIVIHSAPMMVATVKNVIKVTVDGPRDAR 137          
BLAST of runt-2 vs. Ensembl Celegans
Match: rnt-1 (RNT-1; RuNT related; Transcription factor RUN [Source:UniProtKB/TrEMBL;Acc:G5EFQ5])

HSP 1 Score: 119.783 bits (299), Expect = 1.501e-30
Identity = 55/112 (49.11%), Postives = 75/112 (66.96%), Query Frame = 2
Query:  479 GNPNLLCTQLPSHWRINKALVKTFKVFSLLPVADGTQVILSAGNNENVCAELRGNHSQMKNQSAIFQDLRFLGKSGRGKRFNITITMESYPPQVSVYANAIKVTVDGPREPR 814
             +PN+L T LP HWR NK+  + F V  L PV D T+V + AGN+E  C E+R   +++  Q A F DLRF+G+SGRG++F++TI + S P  V+   N IKVTVDGPR+ R
Sbjct:   26 SSPNILYTALPKHWRSNKSFQEPFYVVLLTPVPDNTEVSIWAGNDEKPCEEVRNEKAKVHRQVAKFNDLRFVGRSGRGRKFHLTIVIHSAPMMVATVKNVIKVTVDGPRDAR 137          
BLAST of runt-2 vs. Ensembl Fly
Match: lz (gene:FBgn0002576 transcript:FBtr0071320)

HSP 1 Score: 157.147 bits (396), Expect = 2.404e-41
Identity = 84/186 (45.16%), Postives = 110/186 (59.14%), Query Frame = 2
Query:  410 ELLHAEFTLKRILKNTDSSFVIPGNPNLLCTQLPSHWRINKALVKTFKVFSLLPVADGTQVILSAGNNENVCAELRGNHSQMKNQSAIFQDLRFLGKSGRGKRFNITITMESYPPQVSVYANAIKVTVDGPREPRSNNGSSLKVNKPIRQSPCKFPTYSSPVIEKQLLLDVIQQTADIRRL-NLKR 964
            +LL  E  +++  +      V   NP  LC+ LP+HWR NK L   FKV +L  V DGT V + AGN+EN CAELR   +QMKN  A F DLRF+G+SGRGK F +TIT+ + PPQV+ YA AIKVTVDGPREPRS            + SP   P Y +  + ++  +D    T  +  L +L+R
Sbjct:  268 DLLWMERLVQKRQQEHPGELVRTSNPYFLCSALPAHWRSNKTLPMAFKVVALAEVGDGTYVTIRAGNDENCCAELRNFTTQMKNDVAKFNDLRFVGRSGRGKSFTLTITVATSPPQVATYAKAIKVTVDGPREPRS------------KTSPTGGPHYRALGLGQRPYIDGFPSTKALHELESLRR 441          
BLAST of runt-2 vs. Ensembl Fly
Match: lz (gene:FBgn0002576 transcript:FBtr0112814)

HSP 1 Score: 155.221 bits (391), Expect = 5.543e-41
Identity = 75/136 (55.15%), Postives = 92/136 (67.65%), Query Frame = 2
Query:  410 ELLHAEFTLKRILKNTDSSFVIPGNPNLLCTQLPSHWRINKALVKTFKVFSLLPVADGTQVILSAGNNENVCAELRGNHSQMKNQSAIFQDLRFLGKSGRGKRFNITITMESYPPQVSVYANAIKVTVDGPREPRS 817
            +LL  E  +++  +      V   NP  LC+ LP+HWR NK L   FKV +L  V DGT V + AGN+EN CAELR   +QMKN  A F DLRF+G+SGRGK F +TIT+ + PPQV+ YA AIKVTVDGPREPRS
Sbjct:  268 DLLWMERLVQKRQQEHPGELVRTSNPYFLCSALPAHWRSNKTLPMAFKVVALAEVGDGTYVTIRAGNDENCCAELRNFTTQMKNDVAKFNDLRFVGRSGRGKSFTLTITVATSPPQVATYAKAIKVTVDGPREPRS 403          
BLAST of runt-2 vs. Ensembl Fly
Match: run (gene:FBgn0003300 transcript:FBtr0345922)

HSP 1 Score: 150.599 bits (379), Expect = 3.334e-40
Identity = 72/144 (50.00%), Postives = 95/144 (65.97%), Query Frame = 2
Query:  386 ENKYCMASELLHAEFTLKRILKNTDSSFVIPGNPNLLCTQLPSHWRINKALVKTFKVFSLLPVADGTQVILSAGNNENVCAELRGNHSQMKNQSAIFQDLRFLGKSGRGKRFNITITMESYPPQVSVYANAIKVTVDGPREPRS 817
            +N   M S +     +L  +L+         G+P++LC+ LP+HWR NK+L   FKV +L  V DGT V +  GN+EN C ELR   + MKNQ A F DLRF+G+SGRGK F +TIT+ +YP Q++ Y+ AIKVTVDGPREPRS
Sbjct:   91 QNSAKMPSSMTDMFASLHEMLQEYHGELAQTGSPSILCSALPNHWRSNKSLPGAFKVIALDDVPDGTLVSIKCGNDENYCGELRNCTTTMKNQVAKFNDLRFVGRSGRGKSFTLTITIATYPVQIASYSKAIKVTVDGPREPRS 234          
BLAST of runt-2 vs. Ensembl Fly
Match: run (gene:FBgn0003300 transcript:FBtr0077279)

HSP 1 Score: 150.599 bits (379), Expect = 3.334e-40
Identity = 72/144 (50.00%), Postives = 95/144 (65.97%), Query Frame = 2
Query:  386 ENKYCMASELLHAEFTLKRILKNTDSSFVIPGNPNLLCTQLPSHWRINKALVKTFKVFSLLPVADGTQVILSAGNNENVCAELRGNHSQMKNQSAIFQDLRFLGKSGRGKRFNITITMESYPPQVSVYANAIKVTVDGPREPRS 817
            +N   M S +     +L  +L+         G+P++LC+ LP+HWR NK+L   FKV +L  V DGT V +  GN+EN C ELR   + MKNQ A F DLRF+G+SGRGK F +TIT+ +YP Q++ Y+ AIKVTVDGPREPRS
Sbjct:   91 QNSAKMPSSMTDMFASLHEMLQEYHGELAQTGSPSILCSALPNHWRSNKSLPGAFKVIALDDVPDGTLVSIKCGNDENYCGELRNCTTTMKNQVAKFNDLRFVGRSGRGKSFTLTITIATYPVQIASYSKAIKVTVDGPREPRS 234          
BLAST of runt-2 vs. Ensembl Fly
Match: run (gene:FBgn0003300 transcript:FBtr0304593)

HSP 1 Score: 150.599 bits (379), Expect = 3.499e-40
Identity = 72/144 (50.00%), Postives = 95/144 (65.97%), Query Frame = 2
Query:  386 ENKYCMASELLHAEFTLKRILKNTDSSFVIPGNPNLLCTQLPSHWRINKALVKTFKVFSLLPVADGTQVILSAGNNENVCAELRGNHSQMKNQSAIFQDLRFLGKSGRGKRFNITITMESYPPQVSVYANAIKVTVDGPREPRS 817
            +N   M S +     +L  +L+         G+P++LC+ LP+HWR NK+L   FKV +L  V DGT V +  GN+EN C ELR   + MKNQ A F DLRF+G+SGRGK F +TIT+ +YP Q++ Y+ AIKVTVDGPREPRS
Sbjct:   91 QNSAKMPSSMTDMFASLHEMLQEYHGELAQTGSPSILCSALPNHWRSNKSLPGAFKVIALDDVPDGTLVSIKCGNDENYCGELRNCTTTMKNQVAKFNDLRFVGRSGRGKSFTLTITIATYPVQIASYSKAIKVTVDGPREPRS 234          
BLAST of runt-2 vs. Ensembl Zebrafish
Match: runx2a (RUNX family transcription factor 2a [Source:ZFIN;Acc:ZDB-GENE-040629-3])

HSP 1 Score: 146.362 bits (368), Expect = 6.193e-41
Identity = 73/132 (55.30%), Postives = 89/132 (67.42%), Query Frame = 2
Query:  419 HAEFTLKRILKNTDSSFVIPGNPNLLCTQLPSHWRINKALVKTFKVFSLLPVADGTQVILSAGNNENVCAELRGNHSQMKNQSAIFQDLRFLGKSGRGKRFNITITMESYPPQVSVYANAIKVTVDGPREPR 814
            H   T+  I+ +  +  V   +PN LC+ LPSHWR NK L   FKV +L  V DGT V + AGN+EN  AELR   + MKNQ A F DLRF+G+SGRGK F +TIT+ + PPQV+ Y  AIKVTVDGPREPR
Sbjct:   44 HDNRTMVEIIADHPAELVRTDSPNFLCSVLPSHWRCNKTLPVAFKVVALGDVPDGTVVTVMAGNDENYSAELRNASAVMKNQVARFNDLRFVGRSGRGKSFTLTITVFTNPPQVATYHRAIKVTVDGPREPR 175          
BLAST of runt-2 vs. Ensembl Zebrafish
Match: runx2a (RUNX family transcription factor 2a [Source:ZFIN;Acc:ZDB-GENE-040629-3])

HSP 1 Score: 146.747 bits (369), Expect = 5.181e-39
Identity = 73/132 (55.30%), Postives = 89/132 (67.42%), Query Frame = 2
Query:  419 HAEFTLKRILKNTDSSFVIPGNPNLLCTQLPSHWRINKALVKTFKVFSLLPVADGTQVILSAGNNENVCAELRGNHSQMKNQSAIFQDLRFLGKSGRGKRFNITITMESYPPQVSVYANAIKVTVDGPREPR 814
            H   T+  I+ +  +  V   +PN LC+ LPSHWR NK L   FKV +L  V DGT V + AGN+EN  AELR   + MKNQ A F DLRF+G+SGRGK F +TIT+ + PPQV+ Y  AIKVTVDGPREPR
Sbjct:   44 HDNRTMVEIIADHPAELVRTDSPNFLCSVLPSHWRCNKTLPVAFKVVALGDVPDGTVVTVMAGNDENYSAELRNASAVMKNQVARFNDLRFVGRSGRGKSFTLTITVFTNPPQVATYHRAIKVTVDGPREPR 175          
BLAST of runt-2 vs. Ensembl Zebrafish
Match: runx2a (RUNX family transcription factor 2a [Source:ZFIN;Acc:ZDB-GENE-040629-3])

HSP 1 Score: 146.747 bits (369), Expect = 7.614e-39
Identity = 73/132 (55.30%), Postives = 89/132 (67.42%), Query Frame = 2
Query:  419 HAEFTLKRILKNTDSSFVIPGNPNLLCTQLPSHWRINKALVKTFKVFSLLPVADGTQVILSAGNNENVCAELRGNHSQMKNQSAIFQDLRFLGKSGRGKRFNITITMESYPPQVSVYANAIKVTVDGPREPR 814
            H   T+  I+ +  +  V   +PN LC+ LPSHWR NK L   FKV +L  V DGT V + AGN+EN  AELR   + MKNQ A F DLRF+G+SGRGK F +TIT+ + PPQV+ Y  AIKVTVDGPREPR
Sbjct:   58 HDNRTMVEIIADHPAELVRTDSPNFLCSVLPSHWRCNKTLPVAFKVVALGDVPDGTVVTVMAGNDENYSAELRNASAVMKNQVARFNDLRFVGRSGRGKSFTLTITVFTNPPQVATYHRAIKVTVDGPREPR 189          
BLAST of runt-2 vs. Ensembl Zebrafish
Match: runx3 (RUNX family transcription factor 3 [Source:ZFIN;Acc:ZDB-GENE-000605-2])

HSP 1 Score: 144.05 bits (362), Expect = 3.249e-38
Identity = 74/139 (53.24%), Postives = 92/139 (66.19%), Query Frame = 2
Query:  443 ILKNTDSSFVIPGNPNLLCTQLPSHWRINKALVKTFKVFSLLPVADGTQVILSAGNNENVCAELRGNHSQMKNQSAIFQDLRFLGKSGRGKRFNITITMESYPPQVSVYANAIKVTVDGPREPRSNNGSSLKVNKPIRQ 859
            +L +     V   +PN LC+ LPSHWR NK L   FKV +L  V DGT V + AGN+EN  AELR   + MKNQ A F DLRF+G+SGRGK F +TIT+ + PPQV+ Y  AIKVTVDGPREPR +    +K + P +Q
Sbjct:   51 VLADHAGELVRTDSPNFLCSVLPSHWRCNKTLPVAFKVVALGDVPDGTLVTVMAGNDENYSAELRNASAVMKNQVARFNDLRFVGRSGRGKSFTLTITVFTGPPQVATYHRAIKVTVDGPREPRRHR---VKPDDPHKQ 186          
BLAST of runt-2 vs. Ensembl Zebrafish
Match: runx3 (RUNX family transcription factor 3 [Source:ZFIN;Acc:ZDB-GENE-000605-2])

HSP 1 Score: 144.05 bits (362), Expect = 3.249e-38
Identity = 74/139 (53.24%), Postives = 92/139 (66.19%), Query Frame = 2
Query:  443 ILKNTDSSFVIPGNPNLLCTQLPSHWRINKALVKTFKVFSLLPVADGTQVILSAGNNENVCAELRGNHSQMKNQSAIFQDLRFLGKSGRGKRFNITITMESYPPQVSVYANAIKVTVDGPREPRSNNGSSLKVNKPIRQ 859
            +L +     V   +PN LC+ LPSHWR NK L   FKV +L  V DGT V + AGN+EN  AELR   + MKNQ A F DLRF+G+SGRGK F +TIT+ + PPQV+ Y  AIKVTVDGPREPR +    +K + P +Q
Sbjct:   51 VLADHAGELVRTDSPNFLCSVLPSHWRCNKTLPVAFKVVALGDVPDGTLVTVMAGNDENYSAELRNASAVMKNQVARFNDLRFVGRSGRGKSFTLTITVFTGPPQVATYHRAIKVTVDGPREPRRHR---VKPDDPHKQ 186          
BLAST of runt-2 vs. Ensembl Xenopus
Match: taf4 (TATA-box binding protein associated factor 4 [Source:Xenbase;Acc:XB-GENE-488490])

HSP 1 Score: 145.591 bits (366), Expect = 7.786e-39
Identity = 88/195 (45.13%), Postives = 114/195 (58.46%), Query Frame = 2
Query:  431 TLKRILKNTDSSFVIPGNPNLLCTQLPSHWRINKALVKTFKVFSLLPVADGTQVILSAGNNENVCAELRGNHSQMKNQSAIFQDLRFLGKSGRGKRFNITITMESYPPQVSVYANAIKVTVDGPREPRSNNGSSLKVNKPIRQSPCKFPTY----SSPVIEKQLLLDVIQQT-----ADI-RRLN-LKRLHPLSD 982
            T+  I+ +  +  V   +PN LC+ LPSHWR NK L   FKV +L  V+DG+ V + AGN+EN  AELR   + MKNQ A F DLRF+G+SGRGK F +TIT+ + PPQV+ Y  AIKVTVDGPREPR    +         QS   +P+Y    +SP I     L   + T     +D+ RRL+    L P SD
Sbjct:   61 TMVEIIADHPAELVRTDSPNFLCSVLPSHWRCNKTLPVAFKVVALGEVSDGSVVTVMAGNDENYSAELRNASAVMKNQVARFNDLRFVGRSGRGKSFTLTITVFTNPPQVATYHRAIKVTVDGPREPRHPRQTQSSPPWSYDQS---YPSYLSQMTSPSIHSTTPLSSTRGTGLPAISDVPRRLSGASELGPFSD 252          
BLAST of runt-2 vs. Ensembl Xenopus
Match: znf385d (zinc finger protein 385D [Source:Xenbase;Acc:XB-GENE-1216182])

HSP 1 Score: 144.05 bits (362), Expect = 3.244e-38
Identity = 71/147 (48.30%), Postives = 93/147 (63.27%), Query Frame = 2
Query:  374 LTRIENKYCMASELLHAEFTLKRILKNTDSSFVIPGNPNLLCTQLPSHWRINKALVKTFKVFSLLPVADGTQVILSAGNNENVCAELRGNHSQMKNQSAIFQDLRFLGKSGRGKRFNITITMESYPPQVSVYANAIKVTVDGPREPR 814
            L   ++   +  +L   +  +  +L +     V   +PN LC+ LP+HWR NK L   FKV +L  V DGT V + AGN+EN  AELR   + MKNQ A F DLRF+G+SGRGK F +TIT+ + PPQV+ Y  AIK+TVDGPREPR
Sbjct:   31 LNVTDSSAALVGKLRSTDRNMVEVLSDHPGELVRTDSPNFLCSVLPTHWRCNKTLPIAFKVVALGDVPDGTLVTVMAGNDENYSAELRNATAAMKNQVARFNDLRFVGRSGRGKSFTLTITVFTNPPQVATYHRAIKITVDGPREPR 177          
BLAST of runt-2 vs. Ensembl Xenopus
Match: taf4 (TATA-box binding protein associated factor 4 [Source:Xenbase;Acc:XB-GENE-488490])

HSP 1 Score: 144.436 bits (363), Expect = 4.983e-38
Identity = 71/128 (55.47%), Postives = 89/128 (69.53%), Query Frame = 2
Query:  431 TLKRILKNTDSSFVIPGNPNLLCTQLPSHWRINKALVKTFKVFSLLPVADGTQVILSAGNNENVCAELRGNHSQMKNQSAIFQDLRFLGKSGRGKRFNITITMESYPPQVSVYANAIKVTVDGPREPR 814
            T+  I+ +  +  V   +PN LC+ LPSHWR NK L   FKV +L  V+DG+ V + AGN+EN  AELR   + MKNQ A F DLRF+G+SGRGK F +TIT+ + PPQV+ Y  AIKVTVDGPREPR
Sbjct:   61 TMVEIIADHPAELVRTDSPNFLCSVLPSHWRCNKTLPVAFKVVALGEVSDGSVVTVMAGNDENYSAELRNASAVMKNQVARFNDLRFVGRSGRGKSFTLTITVFTNPPQVATYHRAIKVTVDGPREPR 188          
BLAST of runt-2 vs. Ensembl Xenopus
Match: taf4 (TATA-box binding protein associated factor 4 [Source:Xenbase;Acc:XB-GENE-488490])

HSP 1 Score: 144.05 bits (362), Expect = 8.048e-38
Identity = 71/128 (55.47%), Postives = 89/128 (69.53%), Query Frame = 2
Query:  431 TLKRILKNTDSSFVIPGNPNLLCTQLPSHWRINKALVKTFKVFSLLPVADGTQVILSAGNNENVCAELRGNHSQMKNQSAIFQDLRFLGKSGRGKRFNITITMESYPPQVSVYANAIKVTVDGPREPR 814
            T+  I+ +  +  V   +PN LC+ LPSHWR NK L   FKV +L  V+DG+ V + AGN+EN  AELR   + MKNQ A F DLRF+G+SGRGK F +TIT+ + PPQV+ Y  AIKVTVDGPREPR
Sbjct:   75 TMVEIIADHPAELVRTDSPNFLCSVLPSHWRCNKTLPVAFKVVALGEVSDGSVVTVMAGNDENYSAELRNASAVMKNQVARFNDLRFVGRSGRGKSFTLTITVFTNPPQVATYHRAIKVTVDGPREPR 202          
BLAST of runt-2 vs. Ensembl Xenopus
Match: znf385d (zinc finger protein 385D [Source:Xenbase;Acc:XB-GENE-1216182])

HSP 1 Score: 144.05 bits (362), Expect = 1.155e-37
Identity = 70/143 (48.95%), Postives = 92/143 (64.34%), Query Frame = 2
Query:  386 ENKYCMASELLHAEFTLKRILKNTDSSFVIPGNPNLLCTQLPSHWRINKALVKTFKVFSLLPVADGTQVILSAGNNENVCAELRGNHSQMKNQSAIFQDLRFLGKSGRGKRFNITITMESYPPQVSVYANAIKVTVDGPREPR 814
            ++   +  +L   +  +  +L +     V   +PN LC+ LP+HWR NK L   FKV +L  V DGT V + AGN+EN  AELR   + MKNQ A F DLRF+G+SGRGK F +TIT+ + PPQV+ Y  AIK+TVDGPREPR
Sbjct:   49 DSSAALVGKLRSTDRNMVEVLSDHPGELVRTDSPNFLCSVLPTHWRCNKTLPIAFKVVALGDVPDGTLVTVMAGNDENYSAELRNATAAMKNQVARFNDLRFVGRSGRGKSFTLTITVFTNPPQVATYHRAIKITVDGPREPR 191          
BLAST of runt-2 vs. Ensembl Mouse
Match: Runx2 (runt related transcription factor 2 [Source:MGI Symbol;Acc:MGI:99829])

HSP 1 Score: 146.362 bits (368), Expect = 6.957e-41
Identity = 72/128 (56.25%), Postives = 88/128 (68.75%), Query Frame = 2
Query:  431 TLKRILKNTDSSFVIPGNPNLLCTQLPSHWRINKALVKTFKVFSLLPVADGTQVILSAGNNENVCAELRGNHSQMKNQSAIFQDLRFLGKSGRGKRFNITITMESYPPQVSVYANAIKVTVDGPREPR 814
            T+  I+ +  +  V   +PN LC+ LPSHWR NK L   FKV +L  V DGT V + AGN+EN  AELR   + MKNQ A F DLRF+G+SGRGK F +TIT+ + PPQV+ Y  AIKVTVDGPREPR
Sbjct:    5 TMVEIIADHPAELVRTDSPNFLCSVLPSHWRCNKTLPVAFKVVALGEVPDGTVVTVMAGNDENYSAELRNASAVMKNQVARFNDLRFVGRSGRGKSFTLTITVFTNPPQVATYHRAIKVTVDGPREPR 132          
BLAST of runt-2 vs. Ensembl Mouse
Match: Runx2 (runt related transcription factor 2 [Source:MGI Symbol;Acc:MGI:99829])

HSP 1 Score: 147.517 bits (371), Expect = 1.014e-40
Identity = 73/132 (55.30%), Postives = 89/132 (67.42%), Query Frame = 2
Query:  419 HAEFTLKRILKNTDSSFVIPGNPNLLCTQLPSHWRINKALVKTFKVFSLLPVADGTQVILSAGNNENVCAELRGNHSQMKNQSAIFQDLRFLGKSGRGKRFNITITMESYPPQVSVYANAIKVTVDGPREPR 814
            H   T+  I+ +  +  V   +PN LC+ LPSHWR NK L   FKV +L  V DGT V + AGN+EN  AELR   + MKNQ A F DLRF+G+SGRGK F +TIT+ + PPQV+ Y  AIKVTVDGPREPR
Sbjct:   90 HDNRTMVEIIADHPAELVRTDSPNFLCSVLPSHWRCNKTLPVAFKVVALGEVPDGTVVTVMAGNDENYSAELRNASAVMKNQVARFNDLRFVGRSGRGKSFTLTITVFTNPPQVATYHRAIKVTVDGPREPR 221          
BLAST of runt-2 vs. Ensembl Mouse
Match: Runx1 (runt related transcription factor 1 [Source:MGI Symbol;Acc:MGI:99852])

HSP 1 Score: 147.517 bits (371), Expect = 8.703e-40
Identity = 73/147 (49.66%), Postives = 95/147 (64.63%), Query Frame = 2
Query:  374 LTRIENKYCMASELLHAEFTLKRILKNTDSSFVIPGNPNLLCTQLPSHWRINKALVKTFKVFSLLPVADGTQVILSAGNNENVCAELRGNHSQMKNQSAIFQDLRFLGKSGRGKRFNITITMESYPPQVSVYANAIKVTVDGPREPR 814
            L   +    +AS+L   + ++  +L +     V   +PN LC+ LP+HWR NK L   FKV +L  V DGT V + AGN+EN  AELR   + MKNQ A F DLRF+G+SGRGK F +TIT+ + PPQV+ Y  AIK+TVDGPREPR
Sbjct:   31 LGAPDGGAALASKLRSGDRSMVEVLADHPGELVRTDSPNFLCSVLPTHWRCNKTLPIAFKVVALGDVPDGTLVTVMAGNDENYSAELRNATAAMKNQVARFNDLRFVGRSGRGKSFTLTITVFTNPPQVATYHRAIKITVDGPREPR 177          
BLAST of runt-2 vs. Ensembl Mouse
Match: Runx1 (runt related transcription factor 1 [Source:MGI Symbol;Acc:MGI:99852])

HSP 1 Score: 147.517 bits (371), Expect = 2.714e-39
Identity = 72/143 (50.35%), Postives = 94/143 (65.73%), Query Frame = 2
Query:  386 ENKYCMASELLHAEFTLKRILKNTDSSFVIPGNPNLLCTQLPSHWRINKALVKTFKVFSLLPVADGTQVILSAGNNENVCAELRGNHSQMKNQSAIFQDLRFLGKSGRGKRFNITITMESYPPQVSVYANAIKVTVDGPREPR 814
            +    +AS+L   + ++  +L +     V   +PN LC+ LP+HWR NK L   FKV +L  V DGT V + AGN+EN  AELR   + MKNQ A F DLRF+G+SGRGK F +TIT+ + PPQV+ Y  AIK+TVDGPREPR
Sbjct:   35 DGGAALASKLRSGDRSMVEVLADHPGELVRTDSPNFLCSVLPTHWRCNKTLPIAFKVVALGDVPDGTLVTVMAGNDENYSAELRNATAAMKNQVARFNDLRFVGRSGRGKSFTLTITVFTNPPQVATYHRAIKITVDGPREPR 177          
BLAST of runt-2 vs. Ensembl Mouse
Match: Runx1 (runt related transcription factor 1 [Source:MGI Symbol;Acc:MGI:99852])

HSP 1 Score: 147.517 bits (371), Expect = 3.883e-39
Identity = 73/147 (49.66%), Postives = 95/147 (64.63%), Query Frame = 2
Query:  374 LTRIENKYCMASELLHAEFTLKRILKNTDSSFVIPGNPNLLCTQLPSHWRINKALVKTFKVFSLLPVADGTQVILSAGNNENVCAELRGNHSQMKNQSAIFQDLRFLGKSGRGKRFNITITMESYPPQVSVYANAIKVTVDGPREPR 814
            L   +    +AS+L   + ++  +L +     V   +PN LC+ LP+HWR NK L   FKV +L  V DGT V + AGN+EN  AELR   + MKNQ A F DLRF+G+SGRGK F +TIT+ + PPQV+ Y  AIK+TVDGPREPR
Sbjct:   45 LGAPDGGAALASKLRSGDRSMVEVLADHPGELVRTDSPNFLCSVLPTHWRCNKTLPIAFKVVALGDVPDGTLVTVMAGNDENYSAELRNATAAMKNQVARFNDLRFVGRSGRGKSFTLTITVFTNPPQVATYHRAIKITVDGPREPR 191          
BLAST of runt-2 vs. UniProt/SwissProt
Match: sp|Q9W349|LOZEN_DROME (Protein lozenge OS=Drosophila melanogaster OX=7227 GN=lz PE=2 SV=2)

HSP 1 Score: 157.147 bits (396), Expect = 2.410e-40
Identity = 84/186 (45.16%), Postives = 110/186 (59.14%), Query Frame = 2
Query:  410 ELLHAEFTLKRILKNTDSSFVIPGNPNLLCTQLPSHWRINKALVKTFKVFSLLPVADGTQVILSAGNNENVCAELRGNHSQMKNQSAIFQDLRFLGKSGRGKRFNITITMESYPPQVSVYANAIKVTVDGPREPRSNNGSSLKVNKPIRQSPCKFPTYSSPVIEKQLLLDVIQQTADIRRL-NLKR 964
            +LL  E  +++  +      V   NP  LC+ LP+HWR NK L   FKV +L  V DGT V + AGN+EN CAELR   +QMKN  A F DLRF+G+SGRGK F +TIT+ + PPQV+ YA AIKVTVDGPREPRS            + SP   P Y +  + ++  +D    T  +  L +L+R
Sbjct:  268 DLLWMERLVQKRQQEHPGELVRTSNPYFLCSALPAHWRSNKTLPMAFKVVALAEVGDGTYVTIRAGNDENCCAELRNFTTQMKNDVAKFNDLRFVGRSGRGKSFTLTITVATSPPQVATYAKAIKVTVDGPREPRS------------KTSPTGGPHYRALGLGQRPYIDGFPSTKALHELESLRR 441          
BLAST of runt-2 vs. UniProt/SwissProt
Match: sp|P22814|RUNT_DROME (Segmentation protein Runt OS=Drosophila melanogaster OX=7227 GN=run PE=1 SV=2)

HSP 1 Score: 150.599 bits (379), Expect = 3.342e-39
Identity = 72/144 (50.00%), Postives = 95/144 (65.97%), Query Frame = 2
Query:  386 ENKYCMASELLHAEFTLKRILKNTDSSFVIPGNPNLLCTQLPSHWRINKALVKTFKVFSLLPVADGTQVILSAGNNENVCAELRGNHSQMKNQSAIFQDLRFLGKSGRGKRFNITITMESYPPQVSVYANAIKVTVDGPREPRS 817
            +N   M S +     +L  +L+         G+P++LC+ LP+HWR NK+L   FKV +L  V DGT V +  GN+EN C ELR   + MKNQ A F DLRF+G+SGRGK F +TIT+ +YP Q++ Y+ AIKVTVDGPREPRS
Sbjct:   91 QNSAKMPSSMTDMFASLHEMLQEYHGELAQTGSPSILCSALPNHWRSNKSLPGAFKVIALDDVPDGTLVSIKCGNDENYCGELRNCTTTMKNQVAKFNDLRFVGRSGRGKSFTLTITIATYPVQIASYSKAIKVTVDGPREPRS 234          
BLAST of runt-2 vs. UniProt/SwissProt
Match: sp|Q63046|RUNX1_RAT (Runt-related transcription factor 1 OS=Rattus norvegicus OX=10116 GN=Runx1 PE=1 SV=1)

HSP 1 Score: 147.517 bits (371), Expect = 1.793e-38
Identity = 72/143 (50.35%), Postives = 94/143 (65.73%), Query Frame = 2
Query:  386 ENKYCMASELLHAEFTLKRILKNTDSSFVIPGNPNLLCTQLPSHWRINKALVKTFKVFSLLPVADGTQVILSAGNNENVCAELRGNHSQMKNQSAIFQDLRFLGKSGRGKRFNITITMESYPPQVSVYANAIKVTVDGPREPR 814
            +    +AS+L   + ++  +L +     V   +PN LC+ LP+HWR NK L   FKV +L  V DGT V + AGN+EN  AELR   + MKNQ A F DLRF+G+SGRGK F +TIT+ + PPQV+ Y  AIK+TVDGPREPR
Sbjct:   35 DGGAALASKLRSGDRSMVEVLADHPGELVRTDSPNFLCSVLPTHWRCNKTLPIAFKVVALGDVPDGTLVTVMAGNDENYSAELRNATAAMKNQVARFNDLRFVGRSGRGKSFTLTITVFTNPPQVATYHRAIKITVDGPREPR 177          
BLAST of runt-2 vs. UniProt/SwissProt
Match: sp|Q03347|RUNX1_MOUSE (Runt-related transcription factor 1 OS=Mus musculus OX=10090 GN=Runx1 PE=1 SV=1)

HSP 1 Score: 147.517 bits (371), Expect = 1.918e-38
Identity = 72/139 (51.80%), Postives = 93/139 (66.91%), Query Frame = 2
Query:  398 CMASELLHAEFTLKRILKNTDSSFVIPGNPNLLCTQLPSHWRINKALVKTFKVFSLLPVADGTQVILSAGNNENVCAELRGNHSQMKNQSAIFQDLRFLGKSGRGKRFNITITMESYPPQVSVYANAIKVTVDGPREPR 814
             +AS+L   + ++  +L +     V   +PN LC+ LP+HWR NK L   FKV +L  V DGT V + AGN+EN  AELR   + MKNQ A F DLRF+G+SGRGK F +TIT+ + PPQV+ Y  AIK+TVDGPREPR
Sbjct:   39 ALASKLRSGDRSMVEVLADHPGELVRTDSPNFLCSVLPTHWRCNKTLPIAFKVVALGDVPDGTLVTVMAGNDENYSAELRNATAAMKNQVARFNDLRFVGRSGRGKSFTLTITVFTNPPQVATYHRAIKITVDGPREPR 177          
BLAST of runt-2 vs. UniProt/SwissProt
Match: sp|Q01196|RUNX1_HUMAN (Runt-related transcription factor 1 OS=Homo sapiens OX=9606 GN=RUNX1 PE=1 SV=3)

HSP 1 Score: 146.362 bits (368), Expect = 6.558e-38
Identity = 71/139 (51.08%), Postives = 92/139 (66.19%), Query Frame = 2
Query:  398 CMASELLHAEFTLKRILKNTDSSFVIPGNPNLLCTQLPSHWRINKALVKTFKVFSLLPVADGTQVILSAGNNENVCAELRGNHSQMKNQSAIFQDLRFLGKSGRGKRFNITITMESYPPQVSVYANAIKVTVDGPREPR 814
             +A +L   + ++  +L +     V   +PN LC+ LP+HWR NK L   FKV +L  V DGT V + AGN+EN  AELR   + MKNQ A F DLRF+G+SGRGK F +TIT+ + PPQV+ Y  AIK+TVDGPREPR
Sbjct:   39 ALAGKLRSGDRSMVEVLADHPGELVRTDSPNFLCSVLPTHWRCNKTLPIAFKVVALGDVPDGTLVTVMAGNDENYSAELRNATAAMKNQVARFNDLRFVGRSGRGKSFTLTITVFTNPPQVATYHRAIKITVDGPREPR 177          
BLAST of runt-2 vs. TrEMBL
Match: I1ZI66 (Runt-2 OS=Schmidtea mediterranea OX=79327 PE=2 SV=1)

HSP 1 Score: 298.13 bits (762), Expect = 2.069e-97
Identity = 143/146 (97.95%), Postives = 144/146 (98.63%), Query Frame = 2
Query:  401 MASELLHAEFTLKRILKNTDSSFVIPGNPNLLCTQLPSHWRINKALVKTFKVFSLLPVADGTQVILSAGNNENVCAELRGNHSQMKNQSAIFQDLRFLGKSGRGKRFNITITMESYPPQVSVYANAIKVTVDGPREPRSNNGSSLK 838
            MASELLHAEFTLKRILKNTDSSFVIPGNPNLLCTQLPSHWRINKALVKTFKVFSLLPVADGTQVILSAGNNENVCAELRGNHSQMKNQSAIFQDLRFLGKSGRGKRFNITITMESYPPQVSVYANAIKVTVDGPREPRSNNG S +
Sbjct:    1 MASELLHAEFTLKRILKNTDSSFVIPGNPNLLCTQLPSHWRINKALVKTFKVFSLLPVADGTQVILSAGNNENVCAELRGNHSQMKNQSAIFQDLRFLGKSGRGKRFNITITMESYPPQVSVYANAIKVTVDGPREPRSNNGISWQ 146          
BLAST of runt-2 vs. TrEMBL
Match: A0A1L7H9X8 (Transcriptional regulatory protein Runt-2 OS=Dugesia japonica OX=6161 PE=2 SV=1)

HSP 1 Score: 287.73 bits (735), Expect = 3.126e-93
Identity = 136/146 (93.15%), Postives = 142/146 (97.26%), Query Frame = 2
Query:  401 MASELLHAEFTLKRILKNTDSSFVIPGNPNLLCTQLPSHWRINKALVKTFKVFSLLPVADGTQVILSAGNNENVCAELRGNHSQMKNQSAIFQDLRFLGKSGRGKRFNITITMESYPPQVSVYANAIKVTVDGPREPRSNNGSSLK 838
            MASELL AEFTLKRILKNTDS+FVIPGNP+LLCTQLPSHWRINKALVKTFKVFSLLPVADGTQVILSAGNNEN+CAELRGN SQMKNQ+AIFQDLRFLGKSGRGKRFNITITMESYPPQVSVYANAIKVTVDGPREPR+NNG S +
Sbjct:    1 MASELLQAEFTLKRILKNTDSTFVIPGNPDLLCTQLPSHWRINKALVKTFKVFSLLPVADGTQVILSAGNNENICAELRGNQSQMKNQTAIFQDLRFLGKSGRGKRFNITITMESYPPQVSVYANAIKVTVDGPREPRTNNGISWQ 146          
BLAST of runt-2 vs. TrEMBL
Match: A0A183SL26 (Runt domain-containing protein OS=Schistocephalus solidus OX=70667 GN=SSLN_LOCUS4924 PE=4 SV=1)

HSP 1 Score: 172.94 bits (437), Expect = 4.435e-48
Identity = 85/158 (53.80%), Postives = 111/158 (70.25%), Query Frame = 2
Query:  374 LTRIEN-----KYCMASELLHAEFTLKRILKNTDSSFVIPGNPNLLCTQLPSHWRINKALVKTFKVFSLLPVADGTQVILSAGNNENVCAELRGNHSQMKNQSAIFQDLRFLGKSGRGKRFNITITMESYPPQVSVYANAIKVTVDGPREPRSNNGSS 832
            LTRI+      K+   S++L AE+TL+R L       ++ G+P++LC+ LP HWR NK+L   F+V SL+PV DGT+V+L+AGN E   AEL+   + M+NQ A F DLRFLG+SGRGK FN+TIT+ES PPQV  Y+ AIKVTVDGPR PR+  G S
Sbjct:   35 LTRIQGNLGKLKFGHMSDILLAEYTLRRALHEHAGDLMVTGSPHILCSTLPKHWRSNKSLPTPFRVVSLIPVPDGTRVVLTAGNEERPFAELKNAVAIMQNQEARFNDLRFLGRSGRGKSFNVTITVESNPPQVGTYSRAIKVTVDGPRVPRNKYGKS 192          
BLAST of runt-2 vs. TrEMBL
Match: W6US52 (Runt-related transcription factor OS=Echinococcus granulosus OX=6210 GN=EGR_01216 PE=4 SV=1)

HSP 1 Score: 171.4 bits (433), Expect = 4.754e-47
Identity = 81/142 (57.04%), Postives = 104/142 (73.24%), Query Frame = 2
Query:  401 MASELLHAEFTLKRILKNTDSSFVIPGNPNLLCTQLPSHWRINKALVKTFKVFSLLPVADGTQVILSAGNNENVCAELRGNHSQMKNQSAIFQDLRFLGKSGRGKRFNITITMESYPPQVSVYANAIKVTVDGPREPRSNNG 826
            M+  +L AE+TL+R L       V+ G+P+LLC+ LP HWR NK+L   F+V SL+PV DGT+V+LSAGN E   AEL+   + M+NQ A F DLRFLG+SGRGK FN+TIT+E+ PPQV  Y++AIKVTVDGPR PR+  G
Sbjct:    1 MSDIMLAAEYTLRRALHEHAGDLVVTGSPHLLCSSLPKHWRSNKSLPTPFRVVSLVPVPDGTRVVLSAGNEERPFAELKNAVAVMQNQEARFNDLRFLGRSGRGKSFNVTITVETNPPQVGTYSHAIKVTVDGPRVPRNKYG 142          
BLAST of runt-2 vs. TrEMBL
Match: A0A0R3TQC1 (Runt domain-containing protein OS=Rodentolepis nana OX=102285 GN=HNAJ_LOCUS9730 PE=4 SV=1)

HSP 1 Score: 166.007 bits (419), Expect = 6.561e-46
Identity = 78/142 (54.93%), Postives = 104/142 (73.24%), Query Frame = 2
Query:  401 MASELLHAEFTLKRILKNTDSSFVIPGNPNLLCTQLPSHWRINKALVKTFKVFSLLPVADGTQVILSAGNNENVCAELRGNHSQMKNQSAIFQDLRFLGKSGRGKRFNITITMESYPPQVSVYANAIKVTVDGPREPRSNNG 826
            M+  +L AE+TL+R L  +    V+ G+P+LLC++LP HWR NK+L   F+V SL+PV DGT+V+LSAGN E   AEL+   + M+NQ A F DLRFLG+SGRGK FN+TI +E+ PP +  Y++AIKVTVDGPR PR+  G
Sbjct:    1 MSDLMLAAEYTLRRALDESSGDLVVTGSPHLLCSRLPKHWRSNKSLPTPFRVVSLVPVPDGTRVLLSAGNEERPFAELKNAIAVMQNQEARFNDLRFLGRSGRGKSFNVTINVETNPPLIGTYSHAIKVTVDGPRVPRNKYG 142          
BLAST of runt-2 vs. Ensembl Cavefish
Match: ENSAMXT00000000899.2 (pep primary_assembly:Astyanax_mexicanus-2.0:9:25133550:25206568:-1 gene:ENSAMXG00000000881.2 transcript:ENSAMXT00000000899.2 gene_biotype:protein_coding transcript_biotype:protein_coding)

HSP 1 Score: 144.821 bits (364), Expect = 1.335e-38
Identity = 72/132 (54.55%), Postives = 89/132 (67.42%), Query Frame = 2
Query:  419 HAEFTLKRILKNTDSSFVIPGNPNLLCTQLPSHWRINKALVKTFKVFSLLPVADGTQVILSAGNNENVCAELRGNHSQMKNQSAIFQDLRFLGKSGRGKRFNITITMESYPPQVSVYANAIKVTVDGPREPR 814
            H   ++  I+ +  +  V   +PN LC+ LPSHWR NK L   FKV +L  V DGT V + AGN+EN  AELR   + MKNQ A F DLRF+G+SGRGK F +TIT+ + PPQV+ Y  AIKVTVDGPREPR
Sbjct:   62 HDNRSMVEIIADHPAELVRTDSPNFLCSVLPSHWRCNKTLPVAFKVVALGDVPDGTVVTVMAGNDENYSAELRNASAVMKNQVARFNDLRFVGRSGRGKSFTLTITVFTNPPQVATYHRAIKVTVDGPREPR 193          
BLAST of runt-2 vs. Ensembl Cavefish
Match: runx2b (runt-related transcription factor 2 [Source:NCBI gene;Acc:103028241])

HSP 1 Score: 144.436 bits (363), Expect = 1.715e-38
Identity = 71/128 (55.47%), Postives = 87/128 (67.97%), Query Frame = 2
Query:  431 TLKRILKNTDSSFVIPGNPNLLCTQLPSHWRINKALVKTFKVFSLLPVADGTQVILSAGNNENVCAELRGNHSQMKNQSAIFQDLRFLGKSGRGKRFNITITMESYPPQVSVYANAIKVTVDGPREPR 814
            ++  I+ +  +  V   +PN LC+ LPSHWR NK L   FKV +L  V DGT V + AGN+EN  AELR     MKNQ A F DLRF+G+SGRGK F +TIT+ + PPQV+ Y  AIKVTVDGPREPR
Sbjct:   63 SMAEIIADHPAELVRTDSPNFLCSVLPSHWRCNKTLPVAFKVVALGEVPDGTVVTVMAGNDENYSAELRNASGVMKNQVARFNDLRFVGRSGRGKSFTLTITVFTNPPQVATYHRAIKVTVDGPREPR 190          
BLAST of runt-2 vs. Ensembl Cavefish
Match: runx2b (runt-related transcription factor 2 [Source:NCBI gene;Acc:103028241])

HSP 1 Score: 144.436 bits (363), Expect = 1.957e-38
Identity = 71/128 (55.47%), Postives = 87/128 (67.97%), Query Frame = 2
Query:  431 TLKRILKNTDSSFVIPGNPNLLCTQLPSHWRINKALVKTFKVFSLLPVADGTQVILSAGNNENVCAELRGNHSQMKNQSAIFQDLRFLGKSGRGKRFNITITMESYPPQVSVYANAIKVTVDGPREPR 814
            ++  I+ +  +  V   +PN LC+ LPSHWR NK L   FKV +L  V DGT V + AGN+EN  AELR     MKNQ A F DLRF+G+SGRGK F +TIT+ + PPQV+ Y  AIKVTVDGPREPR
Sbjct:   25 SMAEIIADHPAELVRTDSPNFLCSVLPSHWRCNKTLPVAFKVVALGEVPDGTVVTVMAGNDENYSAELRNASGVMKNQVARFNDLRFVGRSGRGKSFTLTITVFTNPPQVATYHRAIKVTVDGPREPR 152          
BLAST of runt-2 vs. Ensembl Cavefish
Match: runx3 (runt-related transcription factor 3 [Source:NCBI gene;Acc:103041531])

HSP 1 Score: 144.05 bits (362), Expect = 3.101e-38
Identity = 71/124 (57.26%), Postives = 85/124 (68.55%), Query Frame = 2
Query:  443 ILKNTDSSFVIPGNPNLLCTQLPSHWRINKALVKTFKVFSLLPVADGTQVILSAGNNENVCAELRGNHSQMKNQSAIFQDLRFLGKSGRGKRFNITITMESYPPQVSVYANAIKVTVDGPREPR 814
            +L +     V   +PN LC+ LPSHWR NK L   FKV +L  V DGT V + AGN+EN  AELR   + MKNQ A F DLRF+G+SGRGK F +TIT+ + PPQV+ Y  AIKVTVDGPREPR
Sbjct:   77 VLADHAGELVRTDSPNFLCSVLPSHWRCNKTLPVAFKVVALGDVPDGTLVTVMAGNDENYSAELRNASAVMKNQVARFNDLRFVGRSGRGKSFTLTITVFTGPPQVATYHRAIKVTVDGPREPR 200          
BLAST of runt-2 vs. Ensembl Cavefish
Match: runx2b (runt-related transcription factor 2 [Source:NCBI gene;Acc:103028241])

HSP 1 Score: 144.436 bits (363), Expect = 4.326e-38
Identity = 71/128 (55.47%), Postives = 87/128 (67.97%), Query Frame = 2
Query:  431 TLKRILKNTDSSFVIPGNPNLLCTQLPSHWRINKALVKTFKVFSLLPVADGTQVILSAGNNENVCAELRGNHSQMKNQSAIFQDLRFLGKSGRGKRFNITITMESYPPQVSVYANAIKVTVDGPREPR 814
            ++  I+ +  +  V   +PN LC+ LPSHWR NK L   FKV +L  V DGT V + AGN+EN  AELR     MKNQ A F DLRF+G+SGRGK F +TIT+ + PPQV+ Y  AIKVTVDGPREPR
Sbjct:   63 SMAEIIADHPAELVRTDSPNFLCSVLPSHWRCNKTLPVAFKVVALGEVPDGTVVTVMAGNDENYSAELRNASGVMKNQVARFNDLRFVGRSGRGKSFTLTITVFTNPPQVATYHRAIKVTVDGPREPR 190          
BLAST of runt-2 vs. Ensembl Nematostella
Match: EDO33538 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7SRX2])

HSP 1 Score: 147.902 bits (372), Expect = 3.997e-43
Identity = 75/148 (50.68%), Postives = 96/148 (64.86%), Query Frame = 2
Query:  374 LTRIENKYCMASELLHAEFTLKRILKNTDSSFVIPGNPNLLCTQLPSHWRINKALVKTFKVFSLLPVADGTQVILSAGNNENVCAELRGNHSQMKNQSAIFQDLRFLGKSGRGKRFNITITMESYPPQVSVYANAIKVTVDGPREPRS 817
            +T  EN+    +  +  E +L   L       V   +PN +C+ LPSHWR NK L   FKV SL  + DG  V ++AGN+EN  AELR   + MKNQ A F DLRF+G+SGRGK F++TIT+++ PPQV+ Y  AIKVTVDGPREPRS
Sbjct:    1 MTTTENQ---GTRKIKGERSLVEALAEYPGELVKTDSPNFVCSVLPSHWRCNKTLPVAFKVVSLGDIPDGVIVSIAAGNDENFAAELRNATAVMKNQVARFNDLRFVGRSGRGKTFSLTITVKTEPPQVATYCRAIKVTVDGPREPRS 145          
BLAST of runt-2 vs. Ensembl Medaka
Match: runx2 (RUNX family transcription factor 2 [Source:NCBI gene;Acc:100049495])

HSP 1 Score: 144.821 bits (364), Expect = 1.235e-38
Identity = 71/132 (53.79%), Postives = 88/132 (66.67%), Query Frame = 2
Query:  419 HAEFTLKRILKNTDSSFVIPGNPNLLCTQLPSHWRINKALVKTFKVFSLLPVADGTQVILSAGNNENVCAELRGNHSQMKNQSAIFQDLRFLGKSGRGKRFNITITMESYPPQVSVYANAIKVTVDGPREPR 814
            H   ++  I+ +  +  V   +PN LC+ LPSHWR NK L   FKV +L  + DGT V + AGN+EN  AELR     MKNQ A F DLRF+G+SGRGK F +TIT+ + PPQV+ Y  AIKVTVDGPREPR
Sbjct:   23 HENRSMAEIIADHPAELVRTDSPNFLCSVLPSHWRCNKTLPVAFKVVALGDIPDGTVVTVMAGNDENYSAELRNASGVMKNQVARFNDLRFVGRSGRGKSFTLTITVFTNPPQVATYHRAIKVTVDGPREPR 154          
BLAST of runt-2 vs. Ensembl Medaka
Match: runx3 (runt-related transcription factor 3 [Source:NCBI gene;Acc:101160370])

HSP 1 Score: 143.28 bits (360), Expect = 1.976e-38
Identity = 86/196 (43.88%), Postives = 109/196 (55.61%), Query Frame = 2
Query:  443 ILKNTDSSFVIPGNPNLLCTQLPSHWRINKALVKTFKVFSLLPVADGTQVILSAGNNENVCAELRGNHSQMKNQSAIFQDLRFLGKSGRGKRFNITITMESYPPQVSVYANAIKVTVDGPREPRSNNGSSLKVNKPIR-------------QSPCKF-PTYSSPVIEKQLLLDVIQQTADI--RRLNLKRLHPLSD 982
            +L +     V   +PN LC+ LPSHWR NK L   FKV +L  V DGT V + AGN+EN  AELR   + MKNQ A F DLRF+G+SGRGK F +TIT+ + PPQV+ Y  AIKVTVDGPREPR +    +K+  P +             Q   +  P  ++P    Q  L   Q T D   +R     L PL+D
Sbjct:   50 VLADHAGELVRTDSPNFLCSVLPSHWRCNKTLPVAFKVVALGDVPDGTLVTVMAGNDENYSAELRNASAVMKNQVARFNDLRFVGRSGRGKSFTLTITVFTGPPQVATYHRAIKVTVDGPREPRRHR---VKIEDPQKMQFSDRLSEIERYQRTMRIGPVNNNPRPIHQTHLSTTQATTDFFPQRTTFPSLSPLTD 242          
BLAST of runt-2 vs. Ensembl Medaka
Match: runx3 (runt-related transcription factor 3 [Source:NCBI gene;Acc:101160370])

HSP 1 Score: 143.28 bits (360), Expect = 1.984e-38
Identity = 71/125 (56.80%), Postives = 86/125 (68.80%), Query Frame = 2
Query:  443 ILKNTDSSFVIPGNPNLLCTQLPSHWRINKALVKTFKVFSLLPVADGTQVILSAGNNENVCAELRGNHSQMKNQSAIFQDLRFLGKSGRGKRFNITITMESYPPQVSVYANAIKVTVDGPREPRS 817
            +L +     V   +PN LC+ LPSHWR NK L   FKV +L  V DGT V + AGN+EN  AELR   + MKNQ A F DLRF+G+SGRGK F +TIT+ + PPQV+ Y  AIKVTVDGPREPR+
Sbjct:   64 VLADHAGELVRTDSPNFLCSVLPSHWRCNKTLPVAFKVVALGDVPDGTLVTVMAGNDENYSAELRNASAVMKNQVARFNDLRFVGRSGRGKSFTLTITVFTGPPQVATYHRAIKVTVDGPREPRT 188          
BLAST of runt-2 vs. Ensembl Medaka
Match: runx2 (RUNX family transcription factor 2 [Source:NCBI gene;Acc:100049495])

HSP 1 Score: 144.821 bits (364), Expect = 3.002e-38
Identity = 71/132 (53.79%), Postives = 88/132 (66.67%), Query Frame = 2
Query:  419 HAEFTLKRILKNTDSSFVIPGNPNLLCTQLPSHWRINKALVKTFKVFSLLPVADGTQVILSAGNNENVCAELRGNHSQMKNQSAIFQDLRFLGKSGRGKRFNITITMESYPPQVSVYANAIKVTVDGPREPR 814
            H   ++  I+ +  +  V   +PN LC+ LPSHWR NK L   FKV +L  + DGT V + AGN+EN  AELR     MKNQ A F DLRF+G+SGRGK F +TIT+ + PPQV+ Y  AIKVTVDGPREPR
Sbjct:   63 HENRSMAEIIADHPAELVRTDSPNFLCSVLPSHWRCNKTLPVAFKVVALGDIPDGTVVTVMAGNDENYSAELRNASGVMKNQVARFNDLRFVGRSGRGKSFTLTITVFTNPPQVATYHRAIKVTVDGPREPR 194          
BLAST of runt-2 vs. Ensembl Medaka
Match: runx3 (runt-related transcription factor 3 [Source:NCBI gene;Acc:101160370])

HSP 1 Score: 142.895 bits (359), Expect = 6.105e-38
Identity = 71/124 (57.26%), Postives = 85/124 (68.55%), Query Frame = 2
Query:  443 ILKNTDSSFVIPGNPNLLCTQLPSHWRINKALVKTFKVFSLLPVADGTQVILSAGNNENVCAELRGNHSQMKNQSAIFQDLRFLGKSGRGKRFNITITMESYPPQVSVYANAIKVTVDGPREPR 814
            +L +     V   +PN LC+ LPSHWR NK L   FKV +L  V DGT V + AGN+EN  AELR   + MKNQ A F DLRF+G+SGRGK F +TIT+ + PPQV+ Y  AIKVTVDGPREPR
Sbjct:   64 VLADHAGELVRTDSPNFLCSVLPSHWRCNKTLPVAFKVVALGDVPDGTLVTVMAGNDENYSAELRNASAVMKNQVARFNDLRFVGRSGRGKSFTLTITVFTGPPQVATYHRAIKVTVDGPREPR 187          
BLAST of runt-2 vs. Planmine SMEST
Match: SMESG000049171.1 (SMESG000049171.1)

HSP 1 Score: 462.225 bits (1188), Expect = 9.763e-165
Identity = 224/224 (100.00%), Postives = 224/224 (100.00%), Query Frame = 2
Query:  401 MASELLHAEFTLKRILKNTDSSFVIPGNPNLLCTQLPSHWRINKALVKTFKVFSLLPVADGTQVILSAGNNENVCAELRGNHSQMKNQSAIFQDLRFLGKSGRGKRFNITITMESYPPQVSVYANAIKVTVDGPREPRSNNGSSLKVNKPIRQSPCKFPTYSSPVIEKQLLLDVIQQTADIRRLNLKRLHPLSDTDIEKFINDVYKRRKKCLSLSLMTSIDERE 1072
            MASELLHAEFTLKRILKNTDSSFVIPGNPNLLCTQLPSHWRINKALVKTFKVFSLLPVADGTQVILSAGNNENVCAELRGNHSQMKNQSAIFQDLRFLGKSGRGKRFNITITMESYPPQVSVYANAIKVTVDGPREPRSNNGSSLKVNKPIRQSPCKFPTYSSPVIEKQLLLDVIQQTADIRRLNLKRLHPLSDTDIEKFINDVYKRRKKCLSLSLMTSIDERE
Sbjct:    1 MASELLHAEFTLKRILKNTDSSFVIPGNPNLLCTQLPSHWRINKALVKTFKVFSLLPVADGTQVILSAGNNENVCAELRGNHSQMKNQSAIFQDLRFLGKSGRGKRFNITITMESYPPQVSVYANAIKVTVDGPREPRSNNGSSLKVNKPIRQSPCKFPTYSSPVIEKQLLLDVIQQTADIRRLNLKRLHPLSDTDIEKFINDVYKRRKKCLSLSLMTSIDERE 224          
BLAST of runt-2 vs. Planmine SMEST
Match: SMESG000014779.1 (SMESG000014779.1)

HSP 1 Score: 114.39 bits (285), Expect = 1.100e-28
Identity = 59/122 (48.36%), Postives = 78/122 (63.93%), Query Frame = 2
Query:  470 VIP-GNPNLLCTQLPSHWRINKALVKTFKVF------SLLPVADGTQVILSAGNNENVCAELRGNHSQMKNQSAIFQDLRFLGKSGRGKRFNITITMESYPPQVSVYANAIKVTVDGPREPR 814
            ++P  +P + CT+LP HWR NK+L   F+V        +LP+ DG +V LSA N     A LR   S++ N  A F DLRF+ +SGRGK F++ I +E  P  ++VY NAIKVTVDGPREPR
Sbjct:   29 IVPTSHPLVFCTKLPQHWRSNKSLPALFQVMVYQSNNRVLPIGDGHRVWLSASNPSMNSAVLRNFESKLVNGEARFNDLRFISRSGRGKYFDVYIHIECNPKIIAVYTNAIKVTVDGPREPR 150          
The following BLAST results are available for this feature:
BLAST of runt-2 vs. Ensembl Human
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Human e!99)
Total hits: 5
Match NameE-valueIdentityDescription
RUNX21.045e-4055.30RUNX family transcription factor 2 [Source:HGNC Sy... [more]
RUNX11.532e-4051.08RUNX family transcription factor 1 [Source:HGNC Sy... [more]
RUNX11.603e-4051.08RUNX family transcription factor 1 [Source:HGNC Sy... [more]
RUNX25.520e-4055.30RUNX family transcription factor 2 [Source:HGNC Sy... [more]
RUNX15.006e-3951.08RUNX family transcription factor 1 [Source:HGNC Sy... [more]
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BLAST of runt-2 vs. Ensembl Celegans
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99)
Total hits: 2
Match NameE-valueIdentityDescription
rnt-11.501e-3049.11RNT-1; RuNT related; Transcription factor RUN [So... [more]
rnt-11.501e-3049.11RNT-1; RuNT related; Transcription factor RUN [So... [more]
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BLAST of runt-2 vs. Ensembl Fly
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99)
Total hits: 5
Match NameE-valueIdentityDescription
lz2.404e-4145.16gene:FBgn0002576 transcript:FBtr0071320[more]
lz5.543e-4155.15gene:FBgn0002576 transcript:FBtr0112814[more]
run3.334e-4050.00gene:FBgn0003300 transcript:FBtr0345922[more]
run3.334e-4050.00gene:FBgn0003300 transcript:FBtr0077279[more]
run3.499e-4050.00gene:FBgn0003300 transcript:FBtr0304593[more]
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BLAST of runt-2 vs. Ensembl Zebrafish
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99)
Total hits: 5
Match NameE-valueIdentityDescription
runx2a6.193e-4155.30RUNX family transcription factor 2a [Source:ZFIN;A... [more]
runx2a5.181e-3955.30RUNX family transcription factor 2a [Source:ZFIN;A... [more]
runx2a7.614e-3955.30RUNX family transcription factor 2a [Source:ZFIN;A... [more]
runx33.249e-3853.24RUNX family transcription factor 3 [Source:ZFIN;Ac... [more]
runx33.249e-3853.24RUNX family transcription factor 3 [Source:ZFIN;Ac... [more]
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BLAST of runt-2 vs. Ensembl Xenopus
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99)
Total hits: 5
Match NameE-valueIdentityDescription
taf47.786e-3945.13TATA-box binding protein associated factor 4 [Sour... [more]
znf385d3.244e-3848.30zinc finger protein 385D [Source:Xenbase;Acc:XB-GE... [more]
taf44.983e-3855.47TATA-box binding protein associated factor 4 [Sour... [more]
taf48.048e-3855.47TATA-box binding protein associated factor 4 [Sour... [more]
znf385d1.155e-3748.95zinc finger protein 385D [Source:Xenbase;Acc:XB-GE... [more]
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BLAST of runt-2 vs. Ensembl Mouse
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99)
Total hits: 5
Match NameE-valueIdentityDescription
Runx26.957e-4156.25runt related transcription factor 2 [Source:MGI Sy... [more]
Runx21.014e-4055.30runt related transcription factor 2 [Source:MGI Sy... [more]
Runx18.703e-4049.66runt related transcription factor 1 [Source:MGI Sy... [more]
Runx12.714e-3950.35runt related transcription factor 1 [Source:MGI Sy... [more]
Runx13.883e-3949.66runt related transcription factor 1 [Source:MGI Sy... [more]
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BLAST of runt-2 vs. UniProt/SwissProt
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt)
Total hits: 5
Match NameE-valueIdentityDescription
sp|Q9W349|LOZEN_DROME2.410e-4045.16Protein lozenge OS=Drosophila melanogaster OX=7227... [more]
sp|P22814|RUNT_DROME3.342e-3950.00Segmentation protein Runt OS=Drosophila melanogast... [more]
sp|Q63046|RUNX1_RAT1.793e-3850.35Runt-related transcription factor 1 OS=Rattus norv... [more]
sp|Q03347|RUNX1_MOUSE1.918e-3851.80Runt-related transcription factor 1 OS=Mus musculu... [more]
sp|Q01196|RUNX1_HUMAN6.558e-3851.08Runt-related transcription factor 1 OS=Homo sapien... [more]
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BLAST of runt-2 vs. TrEMBL
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL)
Total hits: 5
Match NameE-valueIdentityDescription
I1ZI662.069e-9797.95Runt-2 OS=Schmidtea mediterranea OX=79327 PE=2 SV=... [more]
A0A1L7H9X83.126e-9393.15Transcriptional regulatory protein Runt-2 OS=Duges... [more]
A0A183SL264.435e-4853.80Runt domain-containing protein OS=Schistocephalus ... [more]
W6US524.754e-4757.04Runt-related transcription factor OS=Echinococcus ... [more]
A0A0R3TQC16.561e-4654.93Runt domain-containing protein OS=Rodentolepis nan... [more]
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BLAST of runt-2 vs. Ensembl Cavefish
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99)
Total hits: 5
Match NameE-valueIdentityDescription
ENSAMXT00000000899.21.335e-3854.55pep primary_assembly:Astyanax_mexicanus-2.0:9:2513... [more]
runx2b1.715e-3855.47runt-related transcription factor 2 [Source:NCBI g... [more]
runx2b1.957e-3855.47runt-related transcription factor 2 [Source:NCBI g... [more]
runx33.101e-3857.26runt-related transcription factor 3 [Source:NCBI g... [more]
runx2b4.326e-3855.47runt-related transcription factor 2 [Source:NCBI g... [more]
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BLAST of runt-2 vs. Ensembl Sea Lamprey
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99)
Total hits: 0
Match NameE-valueIdentityDescription
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BLAST of runt-2 vs. Ensembl Yeast
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46)
Total hits: 0
Match NameE-valueIdentityDescription
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BLAST of runt-2 vs. Ensembl Nematostella
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46)
Total hits: 1
Match NameE-valueIdentityDescription
EDO335383.997e-4350.68Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7... [more]
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BLAST of runt-2 vs. Ensembl Medaka
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99)
Total hits: 5
Match NameE-valueIdentityDescription
runx21.235e-3853.79RUNX family transcription factor 2 [Source:NCBI ge... [more]
runx31.976e-3843.88runt-related transcription factor 3 [Source:NCBI g... [more]
runx31.984e-3856.80runt-related transcription factor 3 [Source:NCBI g... [more]
runx23.002e-3853.79RUNX family transcription factor 2 [Source:NCBI ge... [more]
runx36.105e-3857.26runt-related transcription factor 3 [Source:NCBI g... [more]
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BLAST of runt-2 vs. Planmine SMEST
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST)
Total hits: 2
Match NameE-valueIdentityDescription
SMESG000049171.19.763e-165100.00SMESG000049171.1[more]
SMESG000014779.11.100e-2848.36SMESG000014779.1[more]
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Cross References
External references for this transcript
DatabaseAccession
SmedGD GBrowseSMED30013043
GenBankAFJ24720.1
Sequences
The following sequences are available for this feature:

transcript sequence

>SMED30013043 ID=SMED30013043|Name=runt-2|organism=Schmidtea mediterranea sexual|type=transcript|length=1281bp
GCAGCCATGAGTCAGTTATGTAGTCATGCTTGTATGCGTGGGTGTATCAT
ACGAATCGTTGGCATTAGTCTATTTGTAGATTTTGATTCTCGTTGATTAT
TGGTTTTATAAATTCAATCTACAGCTCAATAAATACATTTATTCGCATTC
GCATTAGTATTAGGTCAATACGAGGTTACTGTATCTAGGCTGTGACAATA
TAGATTCATTATATATATACACACACTGACATACACACATAGACATATAC
ACAACTGTTCTGTTGTTGTCATCATTGTACTCGTGTCGCTGTTGTACTAG
ATTATCATCCGGCTGACCAGCATTTATAAATACTCCAATATTTTCATTAT
TCTCGGAATCAACCACAAAAGTGCTAACAAGAATCGAGAACAAATACTGC
ATGGCATCGGAATTGCTACATGCCGAGTTTACGCTGAAGAGGATTTTGAA
AAATACTGACTCGAGCTTTGTCATTCCTGGCAATCCGAACCTTTTATGCA
CCCAGTTGCCGTCTCATTGGAGAATCAACAAGGCGTTGGTGAAAACGTTT
AAAGTCTTTTCGTTGTTGCCGGTTGCCGATGGGACCCAGGTAATTCTATC
TGCTGGAAACAATGAGAATGTCTGTGCTGAATTACGCGGCAATCATTCAC
AGATGAAGAATCAATCTGCGATCTTTCAGGATTTGCGATTTCTCGGGAAA
AGTGGACGAGGAAAGCGGTTCAATATCACAATCACAATGGAATCCTATCC
GCCGCAGGTGTCAGTGTATGCTAACGCGATCAAGGTGACAGTTGATGGGC
CGCGGGAACCCAGATCAAATAATGGAAGTTCATTGAAAGTTAATAAGCCT
ATTCGTCAATCTCCGTGTAAATTTCCCACATATAGTTCTCCTGTTATTGA
AAAGCAGCTCCTTTTGGACGTCATTCAGCAGACCGCCGACATACGGAGGC
TCAATTTAAAACGACTTCATCCGTTATCAGACACAGATATTGAAAAATTT
ATTAATGATGTGTACAAACGTCGAAAGAAATGTCTTTCTTTATCTCTGAT
GACCTCGATAGACGAGAGGGAATGATTAAGAATTGAGAATTGCAATGAGC
ATATAATAGATATATTTGCAGCCCCATATTAGCTCATTCAAATGAATCAC
ATTACCAAAGAGCTTTCAAAAAGAACTGCATAAAGATGTCAATGGTGATG
CCAATGCTGTAGATAAGATAGAGCAGTTTCTATGCCAAAGGTGTTGAGGC
TCAAATAACTATTGATATTTTCATATTACCG
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protein sequence of SMED30013043-orf-1

>SMED30013043-orf-1 ID=SMED30013043-orf-1|Name=SMED30013043-orf-1|organism=Schmidtea mediterranea sexual|type=polypeptide|length=225bp
MASELLHAEFTLKRILKNTDSSFVIPGNPNLLCTQLPSHWRINKALVKTF
KVFSLLPVADGTQVILSAGNNENVCAELRGNHSQMKNQSAIFQDLRFLGK
SGRGKRFNITITMESYPPQVSVYANAIKVTVDGPREPRSNNGSSLKVNKP
IRQSPCKFPTYSSPVIEKQLLLDVIQQTADIRRLNLKRLHPLSDTDIEKF
INDVYKRRKKCLSLSLMTSIDERE*
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Annotated Terms
The following terms have been associated with this transcript:
Vocabulary: Planarian Anatomy
TermDefinition
PLANA:0000026gut
PLANA:0000034epidermis
PLANA:0000070intestinal phagocyte
PLANA:0003116parenchymal cell
Vocabulary: INTERPRO
TermDefinition
IPR000040AML1_Runt
IPR012346p53/RUNT-type_TF_DNA-bd_sf
IPR013524Runt_dom
IPR008967p53-like_TF_DNA-bd
Vocabulary: biological process
TermDefinition
GO:0006355regulation of transcription, DNA-templated
Vocabulary: cellular component
TermDefinition
GO:0005634nucleus
Vocabulary: molecular function
TermDefinition
GO:0005524ATP binding
GO:0003677DNA binding
GO:0003700transcription factor activity, sequence-specific DNA binding
InterPro
Analysis Name: Schmidtea mediteranean smed_20140614 Interproscan
Date Performed: 2020-05-01
IPR TermIPR DescriptionSourceSource TermSource DescriptionAlignment
IPR000040Acute myeloid leukemia 1 protein (AML1)/RuntPRINTSPR00967ONCOGENEAML1coord: 51..70
score: 55.0
coord: 29..50
score: 61.57
coord: 71..92
score: 54.13
coord: 93..114
score: 63.64
coord: 115..137
score: 71.15
IPR000040Acute myeloid leukemia 1 protein (AML1)/RuntPANTHERPTHR11950RUNT RELATEDcoord: 4..156
IPR013524Runt domainPFAMPF00853Runtcoord: 13..140
e-value: 5.6E-51
score: 171.5
IPR013524Runt domainPROSITEPS51062RUNTcoord: 11..139
score: 50.563
IPR012346p53/RUNT-type transcription factor, DNA-binding domain superfamilyGENE3DG3DSA:2.60.40.720coord: 9..150
e-value: 7.3E-56
score: 189.2
NoneNo IPR availablePANTHERPTHR11950:SF31PROTEIN LOZENGE-RELATEDcoord: 4..156
IPR008967p53-like transcription factor, DNA-bindingSUPERFAMILYSSF49417p53-like transcription factorscoord: 16..139