Serine protease hepsin

Overview
NameSerine protease hepsin
Smed IDSMED30013024
Length (bp)2447
Neoblast Clusters

Zeng et. al., 2018



▻ Overview

▻ Neoblast Population

▻ Sub-lethal Irradiated Surviving X1 and X2 Cell Population

 

 

Overview

 

Single cell RNA-seq of pluripotent neoblasts and its early progenies


We isolated X1 neoblasts cells enriched in high piwi-1 expression (Neoblast Population), and profiled ∼7,614 individual cells via scRNA-seq. Unsupervised analyses uncovered 12 distinct classes from 7,088 high-quality cells. We designated these classes Nb1 to Nb12 and ordered them based on high (Nb1) to low (Nb12) piwi-1 expression levels. We further defined groups of genes that best classified the cells parsed into 12 distinct cell clusters to generate a scaled expression heat map of discriminative gene sets for each cluster. Expression of each cluster’s gene signatures was validated using multiplex fluorescence in situ hybridization (FISH) co-stained with piwi-1 and largely confirmed the cell clusters revealed by scRNA-seq.

We also tested sub-lethal irradiation exposure. To profile rare pluripotent stem cells (PSCs) and avoid interference from immediate progenitor cells, we determined a time point after sub-lethal irradiation (7 DPI) with minimal piwi-1+ cells, followed by isolation and single-cell RNA-seq of 1,200 individual cells derived from X1 (Piwi-1 high) and X2 (Piwi-1 low) cell populations (Sub-lethal Irradiated Surviving X1 and X2 Cell Population)



Explore this single cell expression dataset with our NB Cluster Shiny App



 

Neoblast Population

 

t-SNE plot shows two-dimensional representation of global gene expression relationships among all neoblasts (n = 7,088 after filter). Cluster identity was assigned based on the top 10 marker genes of each cluster (Table S2), followed by inspection of RNA in situ hybridization patterns. Neoblast groups, Nb.


Expression of Serine protease hepsin (SMED30013024) t-SNE clustered cells

Violin plots show distribution of expression levels for Serine protease hepsin (SMED30013024) in cells (dots) of each of the 12 neoblast clusters.

 

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Sub-lethal Irradiated Surviving X1 and X2 Cell Population

 

t-SNE plot of surviving X1 and X2 cells (n = 1,039 after QC filter) after sub-lethal irradiation. Colors indicate unbiased cell classification via graph-based clustering. SL, sub-lethal irradiated cell groups.

Expression of Serine protease hepsin (SMED30013024) in the t-SNE clustered sub-lethally irradiated X1 and X2 cells.

Violin plots show distribution of expression levels for Serine protease hepsin (SMED30013024) in cells (dots) of each of the 10 clusters of sub-leathally irradiated X1 and X2 cells.

 

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Embryonic Expression

Davies et. al., 2017

Hover the mouse over a column in the graph to view average RPKM values per sample.
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Embryonic Stages: Y: yolk. S2-S8: Stages 2-8. C4: asexual adult. SX: virgin, sexually mature adult.
For further information about sample preparation and analysis for the single animal RNA-Seq experiment, please refer to the Materials and Methods

 

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Anatomical Expression

PAGE et. al., 2020



SMED30013024

has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGE



PAGE Curations: 8

  
Expressed InReference TranscriptGene ModelsPublished TranscriptTranscriptomePublicationSpecimenLifecycleEvidence
intestinal phagocyteSMED30013024h1SMcG0020454 Contig4066uc_Smed_v2PMID:23079596
Forsthoefel et al., 2012		FACS sorted cell population asexual adult cDNA to DNA expression microarray evidence
intestinal phagocyteSMED30013024h1SMcG0020454 Contig4066newmark_estsPMID:23079596
Forsthoefel et al., 2012		FACS sorted cell population asexual adult cDNA to DNA expression microarray evidence
nervous systemSMED30013024h1SMcG0020454 dd_Smed_v4_18278_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018		FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
cephalic gangliaSMED30013024h1SMcG0020454 dd_Smed_v4_18278_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018		FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
parenchymal cellSMED30013024h1SMcG0020454 dd_Smed_v4_18278_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018		FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
head regionSMED30013024h1SMcG0020454 dd_Smed_v6_18278_0_1dd_Smed_v6PMID:28171748
Stückemann et al., 2017		whole organism asexual adult RNA-sequencing evidence
reproductive organSMED30013024h1SMcG0020454 Contig4066uc_Smed_v2PMID:28434803
Rouhana et al., 2017		whole organism adult hermaphrodite RNA-sequencing evidence
reproductive organSMED30013024h1SMcG0020454 Contig4066newmark_estsPMID:28434803
Rouhana et al., 2017		whole organism adult hermaphrodite RNA-sequencing evidence
Note: Hover over icons to view figure legend
Homology
[Close]
BLAST of Serine protease hepsin vs. Ensembl Human
Match: TMPRSS15 (transmembrane serine protease 15 [Source:HGNC Symbol;Acc:HGNC:9490])

HSP 1 Score: 121.324 bits (303), Expect = 1.769e-27
Identity = 90/280 (32.14%), Postives = 127/280 (45.36%), Query Frame = 2 
Query:  293 RIVSGVNSYYGEWPWIASLKNPVLKELIEKYAPTYMNWSLVGSDSHICGGTLINSEWIVTAQHCLY-YNFSPQAIAITANWSATLGAYDISGY-SQHSISIKIDKVIFQENSFGMDLDDNDFAMMHLSTAVNFTDYIYPACLP-TNPLATPGNICYAVGWGTSYSLNETTNLDDGLSPGHALVNPILKHAT--LLIRERKESKACNTQ-TVKEICTSPLSGSV--CRGDSGGPLLCQGENQSWIFVGITVRGSGCQKKTDRSIFTSVYHYLDFLVQTMNH 1108
            +IV G N+  G WPW+  L               Y    L      +CG +L++S+W+V+A HC+Y  N  P      + W+A LG +  S   S  ++   ID+++   + +     DND AMMHL   VN+TDYI P CLP  N +  PG  C   GWGT      T N              IL+ A   LL  ER + +      T   IC     G +  C+GDSGGPL+CQ EN  W   G+T  G  C       ++  V  + ++ +Q+  H
Sbjct:  784 KIVGGSNAKEGAWPWVVGL---------------YYGGRL------LCGASLVSSDWLVSAAHCVYGRNLEP------SKWTAILGLHMKSNLTSPQTVPRLIDEIVINPH-YNRRRKDNDIAMMHLEFKVNYTDYIQPICLPEENQVFPPGRNCSIAGWGTVVYQGTTAN--------------ILQEADVPLLSNERCQQQMPEYNITENMICAGYEEGGIDSCQGDSGGPLMCQ-ENNRWFLAGVTSFGYKCALPNRPGVYARVSRFTEW-IQSFLH 1019
[Close]
BLAST of Serine protease hepsin vs. Ensembl Human
Match: TMPRSS3 (transmembrane serine protease 3 [Source:HGNC Symbol;Acc:HGNC:11877])

HSP 1 Score: 117.087 bits (292), Expect = 3.713e-27
Identity = 88/285 (30.88%), Postives = 135/285 (47.37%), Query Frame = 2 
Query:  293 RIVSGVNSYYGEWPWIASLKNPVLKELIEKYAPTYMNWSLVGSDSHICGGTLINSEWIVTAQHCLYYNFSPQAIAITANWSATLGAYDISGYSQHSISIKIDKVIFQENSFGMDLDDNDFAMMHLSTAVNFTDYIYPACLPTNPLATP-GNICYAVGWGTSYSLNETTNLDDGLSPGHALVNPILKHATLLIRERKESKACNTQTV-------KEICTSPLSGSV--CRGDSGGPLLCQGENQSWIFVGITVRGSGCQKKTDRSIFTSVYHYLDFLVQTMNHSPK 1117
            RIV G  S   +WPW ASL+        + Y              H+CGG++I   WI+TA HC+Y  + P++      W+  +G   +S     + S  ++K+++        L  ND A+M L+  + F + I P CLP +    P G +C+  GWG +         +DG   G A  +P+L HA + +     +K CN + V         +C   L+G V  C+GDSGGPL+CQ E + W  VG T  G GC +     ++T V  +LD++ + M    K
Sbjct:  214 RIVGGNMSLLSQWPWQASLQ-------FQGY--------------HLCGGSVITPLWIITAAHCVYDLYLPKS------WTIQVGL--VSLLDNPAPSHLVEKIVYHSKYKPKRL-GNDIALMKLAGPLTFNEMIQPVCLPNSEENFPDGKVCWTSGWGAT---------EDG---GDA--SPVLNHAAVPL---ISNKICNHRDVYGGIISPSMLCAGYLTGGVDSCQGDSGGPLVCQ-ERRLWKLVGATSFGIGCAEVNKPGVYTRVTSFLDWIHEQMERDLK 450
[Close]
BLAST of Serine protease hepsin vs. Ensembl Human
Match: TMPRSS3 (transmembrane serine protease 3 [Source:HGNC Symbol;Acc:HGNC:11877])

HSP 1 Score: 117.087 bits (292), Expect = 4.487e-27
Identity = 88/285 (30.88%), Postives = 135/285 (47.37%), Query Frame = 2 
Query:  293 RIVSGVNSYYGEWPWIASLKNPVLKELIEKYAPTYMNWSLVGSDSHICGGTLINSEWIVTAQHCLYYNFSPQAIAITANWSATLGAYDISGYSQHSISIKIDKVIFQENSFGMDLDDNDFAMMHLSTAVNFTDYIYPACLPTNPLATP-GNICYAVGWGTSYSLNETTNLDDGLSPGHALVNPILKHATLLIRERKESKACNTQTV-------KEICTSPLSGSV--CRGDSGGPLLCQGENQSWIFVGITVRGSGCQKKTDRSIFTSVYHYLDFLVQTMNHSPK 1117
            RIV G  S   +WPW ASL+        + Y              H+CGG++I   WI+TA HC+Y  + P++      W+  +G   +S     + S  ++K+++        L  ND A+M L+  + F + I P CLP +    P G +C+  GWG +         +DG   G A  +P+L HA + +     +K CN + V         +C   L+G V  C+GDSGGPL+CQ E + W  VG T  G GC +     ++T V  +LD++ + M    K
Sbjct:  216 RIVGGNMSLLSQWPWQASLQ-------FQGY--------------HLCGGSVITPLWIITAAHCVYDLYLPKS------WTIQVGL--VSLLDNPAPSHLVEKIVYHSKYKPKRL-GNDIALMKLAGPLTFNEMIQPVCLPNSEENFPDGKVCWTSGWGAT---------EDG---GDA--SPVLNHAAVPL---ISNKICNHRDVYGGIISPSMLCAGYLTGGVDSCQGDSGGPLVCQ-ERRLWKLVGATSFGIGCAEVNKPGVYTRVTSFLDWIHEQMERDLK 452
[Close]
BLAST of Serine protease hepsin vs. Ensembl Human
Match: TMPRSS3 (transmembrane serine protease 3 [Source:HGNC Symbol;Acc:HGNC:11877])

HSP 1 Score: 117.087 bits (292), Expect = 4.487e-27
Identity = 88/285 (30.88%), Postives = 135/285 (47.37%), Query Frame = 2 
Query:  293 RIVSGVNSYYGEWPWIASLKNPVLKELIEKYAPTYMNWSLVGSDSHICGGTLINSEWIVTAQHCLYYNFSPQAIAITANWSATLGAYDISGYSQHSISIKIDKVIFQENSFGMDLDDNDFAMMHLSTAVNFTDYIYPACLPTNPLATP-GNICYAVGWGTSYSLNETTNLDDGLSPGHALVNPILKHATLLIRERKESKACNTQTV-------KEICTSPLSGSV--CRGDSGGPLLCQGENQSWIFVGITVRGSGCQKKTDRSIFTSVYHYLDFLVQTMNHSPK 1117
            RIV G  S   +WPW ASL+        + Y              H+CGG++I   WI+TA HC+Y  + P++      W+  +G   +S     + S  ++K+++        L  ND A+M L+  + F + I P CLP +    P G +C+  GWG +         +DG   G A  +P+L HA + +     +K CN + V         +C   L+G V  C+GDSGGPL+CQ E + W  VG T  G GC +     ++T V  +LD++ + M    K
Sbjct:  216 RIVGGNMSLLSQWPWQASLQ-------FQGY--------------HLCGGSVITPLWIITAAHCVYDLYLPKS------WTIQVGL--VSLLDNPAPSHLVEKIVYHSKYKPKRL-GNDIALMKLAGPLTFNEMIQPVCLPNSEENFPDGKVCWTSGWGAT---------EDG---GDA--SPVLNHAAVPL---ISNKICNHRDVYGGIISPSMLCAGYLTGGVDSCQGDSGGPLVCQ-ERRLWKLVGATSFGIGCAEVNKPGVYTRVTSFLDWIHEQMERDLK 452
[Close]
BLAST of Serine protease hepsin vs. Ensembl Human
Match: TMPRSS3 (transmembrane serine protease 3 [Source:HGNC Symbol;Acc:HGNC:11877])

HSP 1 Score: 117.087 bits (292), Expect = 4.712e-27
Identity = 85/285 (29.82%), Postives = 131/285 (45.96%), Query Frame = 2 
Query:  293 RIVSGVNSYYGEWPWIASLKNPVLKELIEKYAPTYMNWSLVGSDSHICGGTLINSEWIVTAQHCLYYNFSPQAIAITANWSATLGAYDISGYSQHSISIKIDKVIFQENSFGMDLDDNDFAMMHLSTAVNFTDYIYPACLPTNPLATP-GNICYAVGWGTSYSLNETTNLDDGLSPGHALVNPILKHATLLIRERKESKACNTQTV-------KEICTSPLSGSV--CRGDSGGPLLCQGENQSWIFVGITVRGSGCQKKTDRSIFTSVYHYLDFLVQTMNHSPK 1117
            RIV G  S   +WPW ASL+        + Y              H+CGG++I   WI+TA HC+Y  + P++      W+  +G   +S     + S  ++K+++        L  ND A+M L+  + F + I P CLP +    P G +C+  GWG +               G    +P+L HA + +     +K CN + V         +C   L+G V  C+GDSGGPL+CQ E + W  VG T  G GC +     ++T V  +LD++ + M    K
Sbjct:  216 RIVGGNMSLLSQWPWQASLQ-------FQGY--------------HLCGGSVITPLWIITAAHCVYDLYLPKS------WTIQVGL--VSLLDNPAPSHLVEKIVYHSKYKPKRL-GNDIALMKLAGPLTFNEMIQPVCLPNSEENFPDGKVCWTSGWGAT-------------EDGAGDASPVLNHAAVPL---ISNKICNHRDVYGGIISPSMLCAGYLTGGVDSCQGDSGGPLVCQ-ERRLWKLVGATSFGIGCAEVNKPGVYTRVTSFLDWIHEQMERDLK 453
[Close]
BLAST of Serine protease hepsin vs. Ensembl Celegans
Match: svh-1 (HGF/MSP/plasminogen-like protein [Source:UniProtKB/TrEMBL;Acc:Q17800])

HSP 1 Score: 93.5893 bits (231), Expect = 2.944e-19
Identity = 71/300 (23.67%), Postives = 127/300 (42.33%), Query Frame = 2 
Query:  227 CGKQMIEKSPQSNNTKIINRYRRIVSGVNSYYGEWPWIASLKNPVLKELIEKYAPTYMNWSLVGSDSHICGGTLINSEWIVTAQHCLYYNFSPQAIAITANWSATLGAYDISGYSQHSISIKIDKVIFQENSFGMDLDDNDFAMMHLS-TAVNFTDYIYPACLPTNPLA-TPGNICYAVGWGTSYSLNETTNLDDGLSPGHALVNPILKHATLLIRERKESKACNTQTVKEICTSPLSGSV--CRGDSGGPLLCQGENQSWIFVGITVRGSGCQKKTDRSIFTSVYHYLDFLVQTMNHSP 1114
            CG + +E + +       +R  R+V G  +  G +PW A+L+N   K                   +H CG ++++   ++TA HC       +     +++   +G +D +    +     + ++ F       D+  +D A++ +    + F +Y  P CLP+     TPG  C   GWG S  L     L        A + PI+     +      S+  ++ +    C   L G +  C+GDSGGP  C+ E+ +++  G+   G GC +K    I+T V  YL ++   +N  P
Sbjct:  693 CGLRYVEVNARDAAK---SRIARVVGGFETVPGAFPWTAALRNKATK-------------------AHHCGASILDKTHLITAAHCF------EEDERVSSYEVVVGDWDNNQTDGNEQIFYLQRIHFYP--LYKDIFSHDIAILEIPYPGIEFNEYAQPICLPSKDFVYTPGRQCVVSGWG-SMGLRYAERL-------QAALIPIINRFDCV----NSSQIYSSMSRSAFCAGYLEGGIDSCQGDSGGPFACRREDGAFVLAGVISWGDGCAQKKQPGIYTMVAPYLSWISAIINGQP 950
[Close]
BLAST of Serine protease hepsin vs. Ensembl Celegans
Match: try-1 (TRYpsin-like protease [Source:UniProtKB/TrEMBL;Acc:Q23528])

HSP 1 Score: 70.0922 bits (170), Expect = 7.897e-13
Identity = 72/288 (25.00%), Postives = 110/288 (38.19%), Query Frame = 2 
Query:  293 RIVSGVNSYYGEWPWIASLKNPVLKELIEKYAPTYMNWSLVGSDSHICGGTLINSEWIVTAQHCLYYNFSPQAIAITANWSATLGAYDISGYSQH---SISIKIDKVIFQENSFGMDLDDNDFAMMHLSTAVNFTDYIYPACLPTNPLATPGNICYAVGWGTSYSLNETTNLDDGLSPGHALVNPILK--HATLLI------------RERKESKACNTQTVKEICTSPLSGSVCRGDSGGPLLCQGENQSWIFVGITVRGSGCQKKTDRSIFTSVYHYLDFLVQTMN 1105
            R++ G  S    WPW   L    L  L                  H CGG+LI+  +++TA HC   +  P +      +S  +G +     S H   ++SI     I   +S+       DFA+M +   VN +    P CLP+ P A    +C   GWG++               G +L  P L+  H  LL             R    S  C   +  +I         C+GDSGGPL+C  +   W   G+   G GC +     ++ +V+    ++   MN
Sbjct:   57 RLIGGSESSPHSWPWTVQL----LSRL----------------GHHRCGGSLIDPNFVLTAAHCFAKDRRPTS------YSVRVGGHRSGSGSPHRVTAVSIHPWYNIGFPSSY-------DFAIMRIHPPVNTSTTARPICLPSLP-AVENRLCVVTGWGSTIE-------------GSSLSAPTLREIHVPLLSTLFCSSLPNYIGRIHLPSMLCAGYSYGKI-------DSCQGDSGGPLMCARDGH-WELTGVVSWGIGCARPGMPGVYGNVHSASTWINLEMN 289
[Close]
BLAST of Serine protease hepsin vs. Ensembl Celegans
Match: try-3 (TRYpsin-like protease [Source:UniProtKB/TrEMBL;Acc:Q94176])

HSP 1 Score: 51.9878 bits (123), Expect = 8.256e-7
Identity = 54/218 (24.77%), Postives = 87/218 (39.91%), Query Frame = 2 
Query:  431 ICGGTLINSEWIVTAQHCLYYNFSPQAIAITANWSATLGAYDISGYSQHSISIKIDKVIFQENSFGMDLDDNDFAMMHLSTAVNFTDYIYPACLPTNPLATPGNICYAVGWGTSYSLNETTNLDDGLSPGHALVN---PILKHATLLIRERKESKACNTQTVKEICTSPLSGSVCRGDSGGPLLCQGENQSWIFVGITVRGS-GCQKKTDRSIFTSVY 1072
            +CG T+I+  W+VTA HC          A+     + +   +     + S S+K     +  + +     DND A++ +S+ ++    I P CL  +           V  G   +L E ++ +  L     L +   PI+     +   R  S      T  +IC          GDSGGPLL    N  ++ +GIT  G+ G     D+  F  VY
Sbjct:   65 LCGATVIDDFWLVTAAHC----------ALQLQTRSFVYVREPKNNRERSFSVK---EAYIHSGYNNQTADNDIALLRISSDLSKLG-IKPVCLVHDDSKLLKQYKNGVVIGYGLTLGEDSSGEPKLINSQTLQSTSVPIISDDDCVKTWRFLSLLSVKITGYQICAGAYLHGTAPGDSGGPLLIHKSNGEYVQIGITSYGADGLDGVIDQGKFPGVY 268
[Close]
BLAST of Serine protease hepsin vs. Ensembl Celegans
Match: try-3 (TRYpsin-like protease [Source:UniProtKB/TrEMBL;Acc:Q94176])

HSP 1 Score: 51.6026 bits (122), Expect = 8.917e-7
Identity = 54/218 (24.77%), Postives = 87/218 (39.91%), Query Frame = 2 
Query:  431 ICGGTLINSEWIVTAQHCLYYNFSPQAIAITANWSATLGAYDISGYSQHSISIKIDKVIFQENSFGMDLDDNDFAMMHLSTAVNFTDYIYPACLPTNPLATPGNICYAVGWGTSYSLNETTNLDDGLSPGHALVN---PILKHATLLIRERKESKACNTQTVKEICTSPLSGSVCRGDSGGPLLCQGENQSWIFVGITVRGS-GCQKKTDRSIFTSVY 1072
            +CG T+I+  W+VTA HC          A+     + +   +     + S S+K     +  + +     DND A++ +S+ ++    I P CL  +           V  G   +L E ++ +  L     L +   PI+     +   R  S      T  +IC          GDSGGPLL    N  ++ +GIT  G+ G     D+  F  VY
Sbjct:   15 LCGATVIDDFWLVTAAHC----------ALQLQTRSFVYVREPKNNRERSFSVK---EAYIHSGYNNQTADNDIALLRISSDLSKLG-IKPVCLVHDDSKLLKQYKNGVVIGYGLTLGEDSSGEPKLINSQTLQSTSVPIISDDDCVKTWRFLSLLSVKITGYQICAGAYLHGTAPGDSGGPLLIHKSNGEYVQIGITSYGADGLDGVIDQGKFPGVY 218
[Close]
BLAST of Serine protease hepsin vs. Ensembl Celegans
Match: T21E12.3 (pep chromosome:WBcel235:I:4401956:4404585:1 gene:WBGene00020655.1 transcript:T21E12.3.1 gene_biotype:protein_coding transcript_biotype:protein_coding gene_symbol:T21E12.3)

HSP 1 Score: 51.9878 bits (123), Expect = 9.327e-7
Identity = 70/321 (21.81%), Postives = 124/321 (38.63%), Query Frame = 2 
Query:  218 QIPCGKQMIEKSPQSNNTKIINRYRRIVSGVNSYYGEWPWIASLKNPVLKELIEKYAPTYMNWSLVGSDSHICGGTLINSEWIVTAQHCLYY-------------------NFSPQAIAITANWSATLGAYDISG-------YSQHSISIKIDKVIFQENSFGMDLDDNDFAMMHLSTAVNFTDYIYPACL--PTNPLATPGNICYAVGWGTSYSLNETTNLDDGLSPGHALVNPILKHATLLIRERKESKACNTQTVKEICTSPLSGS--VCRGDSGGPLLCQGENQSWIFVGITVRGSGCQKKT--DRSIFTSVYHYLD 1084
            +I CG+ +  KS            R++++G+ +   + PW  +++       IE              D  +C GTLI++  ++TA+HC  +                   N + + + +  N + +   Y  +G          +S S+ I K+I  +      LD +DFA++ LS ++  +      C+    + L    N     G+G               S G+    P       L  E  +++ C T T K  CT  +S +   C GDSGG ++ Q  N     VG+   G  C+  T  ++    +V +Y D
Sbjct:   32 KITCGQGLKLKSGYG---------RKVLNGLRTKIEDAPWNVAIE-------IET------------KDVGLCTGTLISTRHVITARHCFAHLMDYGYVSIGKNQLIHGCENDNDEDLVLHGNLTNSFRIYTGTGCGYRKYCKGMNSTSVGIKKIILPKVCDDKQLDFDDFAIVELSESLKMSRKDRFICVNHEDSNLFNENNRMQLFGFGID------------PSAGNQSAGP-------LRSETVKAEKCFTTTGKAFCTKSISKNQLACTGDSGGGVV-QLINDRVTVVGVIYEGVTCEASTTDEQDYVANVAYYSD 304
[Close]
BLAST of Serine protease hepsin vs. Ensembl Fly
Match: CG10663 (gene:FBgn0036287 transcript:FBtr0346570)

HSP 1 Score: 100.908 bits (250), Expect = 1.421e-21
Identity = 88/331 (26.59%), Postives = 141/331 (42.60%), Query Frame = 2 
Query:  131 KSEMNLNPILMIFISCSIKLFSGTKYNLTQIPCGKQMIEKSPQSNNTKIINRYRRIVSGVNSYYGEWPWIASLKNPVLKELIEKYAPTYMNWSLVGSDSHICGGTLINSEWIVTAQHCLYYNFSPQAIAITANWSATLGAYDISGYSQHSISIKIDKVIFQENSFGMDLDDNDFAMMHLSTAVNFTDYIYPACLPTNPLATPGNI-CYAVGWGTSYSLNETTNLDDGLSPGHALVNPILKHATLLIRERKESKACNTQTVKEICTSPLSGSV--CRGDSGGPLLCQG---ENQSWIFVGITVRGSGCQKKTDRSIFTSVYHYLDFLVQTMN 1105
            + E+++N +  I      K + G +Y   ++ CG   I +S      + ++   +I+ G  +  GEWPW  ++ N   KE                     CGGTLI   W++TA HC           +       +G ++++      I +++ K     N F     D+D A++ L  AVN T +I  +CLP    A P N+ C  +GWG   + + T     G S  H    PI+      ++  ++     T T    C     G +  C GDSGGPLLC+     N  W   GIT  G GC ++    I+  V +Y+D++   +N
Sbjct:  460 QPEVSMNDLNYIMTG---KGYRGPEYTPLKLSCG---IVRS--GTGRRSMSNMLKIIGGRAARKGEWPWQVAILN-RFKEAF-------------------CGGTLIAPRWVLTAAHC-----------VRKVLFVRIGEHNLNYEDGTEIQLRVMKSYTHPN-FDKRTVDSDVALLRLPKAVNATTWIGYSCLPQPFQALPKNVDCTIIGWGKRRNRDAT-----GTSVLHKATVPIIP-----MQNCRKVYYDYTITKNMFCAGHQKGHIDTCAGDSGGPLLCRDTTKPNHPWTIFGITSFGDGCAQRNKFGIYAKVPNYVDWVWSVVN 740
[Close]
BLAST of Serine protease hepsin vs. Ensembl Fly
Match: CG10663 (gene:FBgn0036287 transcript:FBtr0113167)

HSP 1 Score: 100.908 bits (250), Expect = 1.421e-21
Identity = 88/331 (26.59%), Postives = 141/331 (42.60%), Query Frame = 2 
Query:  131 KSEMNLNPILMIFISCSIKLFSGTKYNLTQIPCGKQMIEKSPQSNNTKIINRYRRIVSGVNSYYGEWPWIASLKNPVLKELIEKYAPTYMNWSLVGSDSHICGGTLINSEWIVTAQHCLYYNFSPQAIAITANWSATLGAYDISGYSQHSISIKIDKVIFQENSFGMDLDDNDFAMMHLSTAVNFTDYIYPACLPTNPLATPGNI-CYAVGWGTSYSLNETTNLDDGLSPGHALVNPILKHATLLIRERKESKACNTQTVKEICTSPLSGSV--CRGDSGGPLLCQG---ENQSWIFVGITVRGSGCQKKTDRSIFTSVYHYLDFLVQTMN 1105
            + E+++N +  I      K + G +Y   ++ CG   I +S      + ++   +I+ G  +  GEWPW  ++ N   KE                     CGGTLI   W++TA HC           +       +G ++++      I +++ K     N F     D+D A++ L  AVN T +I  +CLP    A P N+ C  +GWG   + + T     G S  H    PI+      ++  ++     T T    C     G +  C GDSGGPLLC+     N  W   GIT  G GC ++    I+  V +Y+D++   +N
Sbjct:  460 QPEVSMNDLNYIMTG---KGYRGPEYTPLKLSCG---IVRS--GTGRRSMSNMLKIIGGRAARKGEWPWQVAILN-RFKEAF-------------------CGGTLIAPRWVLTAAHC-----------VRKVLFVRIGEHNLNYEDGTEIQLRVMKSYTHPN-FDKRTVDSDVALLRLPKAVNATTWIGYSCLPQPFQALPKNVDCTIIGWGKRRNRDAT-----GTSVLHKATVPIIP-----MQNCRKVYYDYTITKNMFCAGHQKGHIDTCAGDSGGPLLCRDTTKPNHPWTIFGITSFGDGCAQRNKFGIYAKVPNYVDWVWSVVN 740
[Close]
BLAST of Serine protease hepsin vs. Ensembl Fly
Match: Corin (gene:FBgn0033192 transcript:FBtr0088909)

HSP 1 Score: 97.4413 bits (241), Expect = 2.788e-20
Identity = 73/289 (25.26%), Postives = 123/289 (42.56%), Query Frame = 2 
Query:  290 RRIVSGVNSYYGEWPWIASLKNPVLKELIEKYAPTYMNWSLVGSDSHI--CGGTLINSEWIVTAQHCLYYNFSPQAIAITANWSATLGAYDISGYSQHSISIKIDKVIFQENSFGMDLDDNDFAMMHLSTAVNFTDYIYPACLPTNPLAT--PGNICYAVGWGTSYSLNETTNLDDGLSPGHALVNPILKHATLLIRERKESKACNTQTVKE--ICTSPLSG--SVCRGDSGGPLLC--QGENQSWIFVGITVRGSGCQKKTDRSIFTSVYHYLDFLVQTMNHSPKNVK 1126
            RRI+ G  +  G WP++A++                     +G    I  C G LI+ +W++TA HC+  N+S   +    +W+  LG    + ++     +K+  VI           DND A+  L+T V F +++ P CLP   +    PG +C  +GWG     +  +  +        +VN +      +I   +  +  +  TV E  +C     G    C+GDSGGPLLC   GE   W   GI   G  C       ++ +V  Y+ ++ + +    + +K
Sbjct: 1102 RRIIGGTQASPGNWPFLAAI---------------------LGGPEKIFYCAGVLISDQWVLTASHCVG-NYS---VIDLEDWTIQLGVTRRNSFTYSGQKVKVKAVIPHPQYNMAIAHDNDIALFQLATRVAFHEHLLPVCLPPPSVRNLHPGTLCTVIGWGKREDKDPKSTYE-------YIVNEV---QVPIITRNQCDEWLDNLTVSEGMVCAGFDDGGKDACQGDSGGPLLCPYPGEKNRWFVGGIVSWGIMCAHPRLPGVYANVVQYVPWIQEQIAKHSRPIK 1355
[Close]
BLAST of Serine protease hepsin vs. Ensembl Fly
Match: Corin (gene:FBgn0033192 transcript:FBtr0336996)

HSP 1 Score: 97.4413 bits (241), Expect = 2.788e-20
Identity = 73/289 (25.26%), Postives = 123/289 (42.56%), Query Frame = 2 
Query:  290 RRIVSGVNSYYGEWPWIASLKNPVLKELIEKYAPTYMNWSLVGSDSHI--CGGTLINSEWIVTAQHCLYYNFSPQAIAITANWSATLGAYDISGYSQHSISIKIDKVIFQENSFGMDLDDNDFAMMHLSTAVNFTDYIYPACLPTNPLAT--PGNICYAVGWGTSYSLNETTNLDDGLSPGHALVNPILKHATLLIRERKESKACNTQTVKE--ICTSPLSG--SVCRGDSGGPLLC--QGENQSWIFVGITVRGSGCQKKTDRSIFTSVYHYLDFLVQTMNHSPKNVK 1126
            RRI+ G  +  G WP++A++                     +G    I  C G LI+ +W++TA HC+  N+S   +    +W+  LG    + ++     +K+  VI           DND A+  L+T V F +++ P CLP   +    PG +C  +GWG     +  +  +        +VN +      +I   +  +  +  TV E  +C     G    C+GDSGGPLLC   GE   W   GI   G  C       ++ +V  Y+ ++ + +    + +K
Sbjct: 1102 RRIIGGTQASPGNWPFLAAI---------------------LGGPEKIFYCAGVLISDQWVLTASHCVG-NYS---VIDLEDWTIQLGVTRRNSFTYSGQKVKVKAVIPHPQYNMAIAHDNDIALFQLATRVAFHEHLLPVCLPPPSVRNLHPGTLCTVIGWGKREDKDPKSTYE-------YIVNEV---QVPIITRNQCDEWLDNLTVSEGMVCAGFDDGGKDACQGDSGGPLLCPYPGEKNRWFVGGIVSWGIMCAHPRLPGVYANVVQYVPWIQEQIAKHSRPIK 1355
[Close]
BLAST of Serine protease hepsin vs. Ensembl Fly
Match: CG9372 (gene:FBgn0036891 transcript:FBtr0074945)

HSP 1 Score: 91.6633 bits (226), Expect = 3.243e-19
Identity = 76/290 (26.21%), Postives = 119/290 (41.03%), Query Frame = 2 
Query:  242 IEKSPQSNNTKIINR-YRRIVSGVNSYYGEWPWIASLKNPVLKELIEKYAPTYMNWSLVGSDSHICGGTLINSEWIVTAQHCLYYNFSPQAIAITANWSATLGAYDISGYSQ-HSISIKIDKVIFQENSFGMDLDDNDFAMMHLSTAVNFTDYIYPACLPTNPLATPGNICYAVGWGTSYSLNETTNLDDGLSPGHALVNPILKHATLLIRERKESKACNTQTVKE--ICTSPLSG--SVCRGDSGGPLLCQGENQSWIFVGITVRGSGCQKKTDRSIFTSVYHYLDFLV 1093
            I   P+     I +R + R+  G  +   EWPW+A+L    L+E               G     CGG LI    ++TA HC+Y                 LG Y+    ++  +   +I  ++   +    + D ND A++ +  A  F  YI+P C+P              GWGT       +N              IL    L + ++ + ++   Q V +  +C     G    C+GDSGGPLL Q  NQ W+ +GI   G GC ++    I+T V  YLD+++
Sbjct:  155 IVNKPEQRGCGITSRQFPRLTGGRPAEPDEWPWMAAL----LQE---------------GLPFVWCGGVLITDRHVLTAAHCIYKKNKEDIFV-------RLGEYNTHMLNETRARDFRIANMVLHIDYNPQNYD-NDIAIVRIDRATIFNTYIWPVCMPPVNEDWSDRNAIVTGWGTQKFGGPHSN--------------ILMEVNLPVWKQSDCRSSFVQHVPDTAMCAGFPEGGQDSCQGDSGGPLLVQLPNQRWVTIGIVSWGVGCGQRGRPGIYTRVDRYLDWIL 403
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BLAST of Serine protease hepsin vs. Ensembl Zebrafish
Match: tmprss5 (transmembrane serine protease 5 [Source:ZFIN;Acc:ZDB-GENE-131121-184])

HSP 1 Score: 124.79 bits (312), Expect = 2.125e-29
Identity = 85/275 (30.91%), Postives = 132/275 (48.00%), Query Frame = 2 
Query:  293 RIVSGVNSYYGEWPWIASLKNPVLKELIEKYAPTYMNWSLVGSDSHICGGTLINSEWIVTAQHCLYYNFSPQAIAITANWSATLG--AYDISGYSQHSISIKIDKVIFQENSFGMDLDDNDFAMMHLSTAVNFTDYIYPACLPTNPLATPGNI-CYAVGWGTSYSLNETTNLDDGLSPGHALVNPILKHATL-LIRERKESKAC---NTQTVKEICTSPLSGSV--CRGDSGGPLLCQGENQSWIFVGITVRGSGCQKKTDRSIFTSVYHYLDFL 1090
            RI+ GV +  G WPW  SL               Y N      + HICGG++I ++WIVTA HC++    PQ      +W    G    +++  +Q+     ++++I+ +N +     DND A++ L T +NF+D I P CLP      PG   C+  GWG +              P   L+  +LK A + LI  +K + +C      T + +C     G V  C+GDSGGPL+CQ EN  W  VG+   G+GC +     +++ V  +L ++
Sbjct:  311 RIIGGVEAALGRWPWQVSL---------------YYN------NRHICGGSIITNQWIVTAAHCVHNYRLPQ----VPSWVVYAGIITSNLAKLAQYQ-GFAVERIIYNKN-YNHRTHDNDIALVKLKTPLNFSDTIRPVCLPQYDHDLPGGTQCWISGWGYT-------------QPDDVLIPEVLKEAPVPLISTKKCNSSCMYNGEITSRMLCAGYSEGKVDACQGDSGGPLVCQDEN-VWRLVGVVSWGTGCAEPNHPGVYSKVAEFLGWI 544
[Close]
BLAST of Serine protease hepsin vs. Ensembl Zebrafish
Match: tmprss5 (transmembrane serine protease 5 [Source:ZFIN;Acc:ZDB-GENE-131121-184])

HSP 1 Score: 124.79 bits (312), Expect = 3.203e-29
Identity = 85/275 (30.91%), Postives = 132/275 (48.00%), Query Frame = 2 
Query:  293 RIVSGVNSYYGEWPWIASLKNPVLKELIEKYAPTYMNWSLVGSDSHICGGTLINSEWIVTAQHCLYYNFSPQAIAITANWSATLG--AYDISGYSQHSISIKIDKVIFQENSFGMDLDDNDFAMMHLSTAVNFTDYIYPACLPTNPLATPGNI-CYAVGWGTSYSLNETTNLDDGLSPGHALVNPILKHATL-LIRERKESKAC---NTQTVKEICTSPLSGSV--CRGDSGGPLLCQGENQSWIFVGITVRGSGCQKKTDRSIFTSVYHYLDFL 1090
            RI+ GV +  G WPW  SL               Y N      + HICGG++I ++WIVTA HC++    PQ      +W    G    +++  +Q+     ++++I+ +N +     DND A++ L T +NF+D I P CLP      PG   C+  GWG +              P   L+  +LK A + LI  +K + +C      T + +C     G V  C+GDSGGPL+CQ EN  W  VG+   G+GC +     +++ V  +L ++
Sbjct:  311 RIIGGVEAALGRWPWQVSL---------------YYN------NRHICGGSIITNQWIVTAAHCVHNYRLPQ----VPSWVVYAGIITSNLAKLAQYQ-GFAVERIIYNKN-YNHRTHDNDIALVKLKTPLNFSDTIRPVCLPQYDHDLPGGTQCWISGWGYT-------------QPDDVLIPEVLKEAPVPLISTKKCNSSCMYNGEITSRMLCAGYSEGKVDACQGDSGGPLVCQDEN-VWRLVGVVSWGTGCAEPNHPGVYSKVAEFLGWI 544
[Close]
BLAST of Serine protease hepsin vs. Ensembl Zebrafish
Match: tmprss15 (transmembrane serine protease 15 [Source:ZFIN;Acc:ZDB-GENE-091204-83])

HSP 1 Score: 125.176 bits (313), Expect = 7.323e-29
Identity = 89/296 (30.07%), Postives = 143/296 (48.31%), Query Frame = 2 
Query:  224 PCGKQMIEKSPQSNNTKIINRYRRIVSGVNSYYGEWPWIASLKNPVLKELIEKYAPTYMNWSLVGSDSHICGGTLINSEWIVTAQHCLYYNFSPQAIAITANWSATLGAY-DISGYSQHSISIKIDKVIFQENSFGMDLDDNDFAMMHLSTAVNFTDYIYPACLPTNPLA--TPGNICYAVGWGTSYSLNETTNLDDGLSPGHALVNPILKHATLLIRERKESKACNTQTVKEICTSPLSGSV--CRGDSGGPLLCQGENQSWIFVGITVRGSGCQKKTDRSIFTSVYHYLDFLVQ 1096
            PCG + +    +        +  R+V G ++  G WPW+ SL+                 W L G   H CG TLI+ EW++TA HC+Y     + + ++ NW+A LG +      + +     +D+VI  ++ +     ++DFA+MHL T V++TDY+ P CLP +P A    G  C+  GWG    L+E+  + D L      V P+L +      + +E       T + +C     G V  C+GDSGGPL+C+ E   W+ VG T  G GC +      +  V  ++D++ +
Sbjct:  619 PCGVRKVPSKSKIIEETDGKKEGRVVGGQDAQRGAWPWMVSLQ-----------------W-LGG---HACGATLIDREWLITAAHCVY----GRNVQLS-NWAAVLGLHAQFETINPNKQVFSVDQVIMHKH-YNKRTKESDFALMHLKTPVSYTDYVQPICLP-DPGAHFEEGRKCFIAGWGL---LSESGQISDVL---QQAVVPLLSNT-----QCQEWLPEYNFTERMMCAGYAEGGVDTCQGDSGGPLMCEEEGH-WVLVGATSFGIGCGRPQRPGAYARVSQFVDWVAE 874
[Close]
BLAST of Serine protease hepsin vs. Ensembl Zebrafish
Match: tmprss15 (transmembrane serine protease 15 [Source:ZFIN;Acc:ZDB-GENE-091204-83])

HSP 1 Score: 122.479 bits (306), Expect = 5.374e-28
Identity = 91/304 (29.93%), Postives = 147/304 (48.36%), Query Frame = 2 
Query:  224 PCGKQMIEKSPQSNNTKIIN-----RYRRIVSGVNSYYGEWPWIASLKNPVLKELIEKYAPTYMNWSLVGSDSHICGGTLINSEWIVTAQHCLYYNFSPQAIAITANWSATLGAY-DISGYSQHSISIKIDKVIFQENSFGMDLDDNDFAMMHLSTAVNFTDYIYPACLPTNPLA--TPGNICYAVGWGTSYSLNETTNLDDGLSPGHALVNPILKHATLLIRERKESKACNTQ---TVKEICTSPLSGSV--CRGDSGGPLLCQGENQSWIFVGITVRGSGCQKKTDRSIFTSVYHYLDFLVQ 1096
            PCG   + K P  + +KII      +  R+V G ++  G WPW+ SL+                 W L G   H CG TLI+ EW++TA HC+Y     + + ++ NW+A LG +      + +     +D+VI  ++ +     ++DFA+MHL T V++TDY+ P CLP +P A    G  C+  GWG    L+E+            L   +L+ A + +    + +    +   T + +C     G V  C+GDSGGPL+C+ E   W+ VG T  G GC +      +  V  ++D++ +
Sbjct:  724 PCG---VRKVP--SKSKIIEETDGKKEGRVVGGQDAQRGAWPWMVSLQ-----------------W-LGG---HACGATLIDREWLITAAHCVY----GRNVQLS-NWAAVLGLHAQFETINPNKQVFSVDQVIMHKH-YNKRTKESDFALMHLKTPVSYTDYVQPICLP-DPGAHFEEGRKCFIAGWGL---LSES-----------GLKADVLQQAVVPLLSNTQCQEWLPEYNFTERMMCAGYAEGGVDTCQGDSGGPLMCEEEGH-WVLVGATSFGIGCGRPQRPGAYARVSQFVDWVAE 979
[Close]
BLAST of Serine protease hepsin vs. Ensembl Zebrafish
Match: ela2l (elastase 2 like [Source:ZFIN;Acc:ZDB-GENE-040511-1])

HSP 1 Score: 114.005 bits (284), Expect = 1.120e-27
Identity = 89/277 (32.13%), Postives = 126/277 (45.49%), Query Frame = 2 
Query:  293 RIVSGVNSYYGEWPWIASLKNPVLKELIEKYAPTYMNWSLVGSDSHICGGTLINSEWIVTAQHCLYYNFSPQAIAITANWSATLGAYDISGYSQHSISIKIDKVIFQE--NSFGMDLDDNDFAMMHLSTAVNFTDYIYPACLPTNPLATPGNI-CYAVGWGTSYSLNETTNLDDGLSPGHALVNPILKHATLLIRERKESKACNTQTVKEICTSPLSGSV--CRGDSGGPLLCQGENQSWIFVGITVRGSG--CQKKTDRSIFTSVYHYLDFLVQTM 1102
            R+V GV+     WPW  SL+             +  NW       H CGG+LI+ +W++TA HC         I+ +  +   LG + +S     S++I   K+I  E  NSF +    ND A++ L TAV   D I PACLP      P N  CY  GWG  Y+     ++        AL+ P++ HAT       +S    +Q    +  +   G V  C GDSGGPL C G + +W   GI   GSG  C      ++FT V  Y D++ + M
Sbjct:   28 RVVGGVDVRPNSWPWQISLQ-----------YKSGSNWY------HTCGGSLIDKQWVLTAAHC---------ISSSRTYRVFLGKHSLSQEENGSVAIGAGKIIVHEAWNSFTIR---NDIALIKLETAVTIGDTITPACLPEAGYVLPHNAPCYVTGWGRLYTNGPLADILQ-----QALL-PVVDHATC-----SKSDWWGSQVTTSMVCAGGDGVVAGCNGDSGGPLNCAGSDGAWEVHGIVSFGSGLSCNYNKKPTVFTRVSAYSDWISKNM 264
[Close]
BLAST of Serine protease hepsin vs. Ensembl Xenopus
Match: ENSXETT00000031482.1 (pep primary_assembly:Xenopus_tropicalis_v9.1:9:2461482:2465796:1 gene:ENSXETG00000009419.1 transcript:ENSXETT00000031482.1 gene_biotype:protein_coding transcript_biotype:protein_coding)

HSP 1 Score: 132.109 bits (331), Expect = 7.570e-33
Identity = 88/301 (29.24%), Postives = 138/301 (45.85%), Query Frame = 2 
Query:  230 GKQMIEKSPQSNNTKIINRYRRIVSGVNSYYGEWPWIASLKNPVLKELIEKYAPTYMNWSLVGSDSHICGGTLINSEWIVTAQHCLYYNFSPQAIAITANWSATLGAYDISGYSQHSISIKIDKVIFQENSFGMDLDDNDFAMMHLSTAVNFTDYIYPACLPTNPLATP-GNICYAVGWGTSYSLNETTNLDDGLSPGHALVNPILKHATLLIRERKESKACNTQTVKEICTSPLSG--SVCRGDSGGPLLCQGENQSWIFVGITVRGSGCQKKTDRSIFTSVYHYLDFLVQTMNHSPKNV 1123
            G +  ++ PQ +  + +    RIV GVNS  G WPW   L+ P                      +  CGG+LI S+WI++A HC +   +P      +N++   GAY++SG + H + +K+   I   N +      +D  +M L T +NFT YI P CLP + +A P G  C+  GWG         N+   L P   L   ++      + +   S+  N  T   IC   +SG   +C+GDSGGPL+C  +   W   GI   G  C++K   S++     ++D++   +     NV
Sbjct:    9 GARAEKQEPQGSEARPL--LSRIVGGVNSRPGMWPWQVYLRGP----------------------NFFCGGSLITSKWIISAAHCCHSTLTP------SNYTVYAGAYNLSGANSHEVKVKVKNFIINPN-YTTFTKGSDICLMELQTELNFTQYISPVCLPASGVAFPTGLPCWVTGWG---------NIALSLPPPKTLQEVLVPLIGAQVCKSYYSRVANI-TDNMICAGYVSGGKGICQGDSGGPLVC-AQADRWYLAGIVSFGIPCEQKYYPSVYGRSNAFVDWITTLVPEVSPNV 267
[Close]
BLAST of Serine protease hepsin vs. Ensembl Xenopus
Match: ENSXETT00000021860.1 (pep primary_assembly:Xenopus_tropicalis_v9.1:KV461533.1:11451:13378:1 gene:ENSXETG00000011244.1 transcript:ENSXETT00000021860.1 gene_biotype:protein_coding transcript_biotype:protein_coding)

HSP 1 Score: 128.642 bits (322), Expect = 7.418e-32
Identity = 86/295 (29.15%), Postives = 143/295 (48.47%), Query Frame = 2 
Query:  266 NTKIINRYRRIVSGVNSYYGEWPWIASLKNPVLKELIEKYAPTYMNWSLVGSDSHICGGTLINSEWIVTAQHCLYYNFSPQAIAITANWSATLGAYDISGYSQHSISIKIDKVIFQENSFGMDLDDNDFAMMHLSTAVNFTDYIYPACLPTNPLATPGNI-CYAVGWGTSYSLNETTNLDDGLSPGHALVNPILKHATLLIRERKESKACNTQ-----TVKE--ICTSPLSGSV--CRGDSGGPLLCQGE-NQSWIFVGITVRGSGCQKKTDRSIFTSVYHYLDFLVQTMNHSPK 1117
            N  + N+  RIV G NS  G+WPW+ S+++P  KE                  SH+CGG+++N  W++TA HC    F  +    T +W    GA ++    + S+ I+  K + Q  ++    + ND  ++ L   + FTDY+ PAC PT          CY  GWG    L+E +       P       IL+ A +    + +SK CN++     ++ E  +C     G +  C+GDSGGPL+C+ + ++++  VGIT  GSGC +     ++TS  +++ ++   +    K
Sbjct:   34 NRPLFNKGSRIVGGQNSPPGKWPWMVSIQSPTGKEF-----------------SHLCGGSVLNEIWVLTAAHC----FKKEE---TKSWRLVFGANNLK-VLESSVQIRKIKEVVQPKAYNPTTEANDITLLRLDKPIVFTDYVQPACFPTEFANVEKKTDCYIAGWGV---LDEESG-----EPSE-----ILQEARV---HQIDSKKCNSKDWYDGSIGEYNLCAGHEKGGIDSCQGDSGGPLMCKTQKSRTYAVVGITSWGSGCARGKKPGVYTSTKYFIKWIASKVETDEK 287
[Close]
BLAST of Serine protease hepsin vs. Ensembl Xenopus
Match: ENSXETT00000035256.1 (pep primary_assembly:Xenopus_tropicalis_v9.1:KV461533.1:11712:13373:1 gene:ENSXETG00000011244.1 transcript:ENSXETT00000035256.1 gene_biotype:protein_coding transcript_biotype:protein_coding)

HSP 1 Score: 126.331 bits (316), Expect = 9.186e-32
Identity = 85/284 (29.93%), Postives = 140/284 (49.30%), Query Frame = 2 
Query:  266 NTKIINRYRRIVSGVNSYYGEWPWIASLKNPVLKELIEKYAPTYMNWSLVGSDSHICGGTLINSEWIVTAQHCLYYNFSPQAIAITANWSATLGAYDISGYSQHSISIKIDKVIFQENSFGMDLDDNDFAMMHLSTAVNFTDYIYPACLPTNPLATPGNI-CYAVGWGTSYSLNETTNLDDGLSPGHALVNPILKHATLLIRERKESKACNTQ-----TVKE--ICTSPLSGSV--CRGDSGGPLLCQGE-NQSWIFVGITVRGSGCQKKTDRSIFTSVYHYLD 1084
            N  + N+  RIV G NS  G+WPW+ S+++P  KE                  SH+CGG+++N  W++TA HC    F  +    T +W    GA ++    + S+ I+  K + Q  ++    + ND  ++ L   + FTDY+ PAC PT          CY  GWG    L+E +       P       IL+ A +    + +SK CN++     ++ E  +C     G +  C+GDSGGPL+C+ + ++++  VGIT  GSGC +     ++TS  ++++
Sbjct:   21 NRPLFNKGSRIVGGQNSPPGKWPWMVSIQSPTGKEF-----------------SHLCGGSVLNEIWVLTAAHC----FKKEE---TKSWRLVFGANNLK-VLESSVQIRKIKEVVQPKAYNPTTEANDITLLRLDKPIVFTDYVQPACFPTEFANVEKKTDCYIAGWGV---LDEESG-----EPSE-----ILQEARV---HQIDSKKCNSKDWYDGSIGEYNLCAGHEKGGIDSCQGDSGGPLMCKTQKSRTYAVVGITSWGSGCARGKKPGVYTSTKYFIN 263
[Close]
BLAST of Serine protease hepsin vs. Ensembl Xenopus
Match: ENSXETT00000030834.1 (serine protease 27-like [Source:NCBI gene;Acc:100495541])

HSP 1 Score: 125.561 bits (314), Expect = 8.042e-31
Identity = 88/274 (32.12%), Postives = 131/274 (47.81%), Query Frame = 2 
Query:  293 RIVSGVNSYYGEWPWIASLKNPVLKELIEKYAPTYMNWSLVGSDSHICGGTLINSEWIVTAQHCLYYNFSPQAIAITANWSATLGAYDISGYSQHSISIKIDKVIFQENSFGMDLDDNDFAMMHLSTAVNFTDYIYPACLP-TNPLATPGNICYAVGWGTSYSLNETTNLDDGLSPGHALVNPILKHATLLIRERKESKACNTQTVKEICTSPLSG--SVCRGDSGGPLLCQGENQSWIFVGITVRGSGCQKKTDRSIFTSVYHYLDFLVQTMN 1105
            RIV G ++  G WPW  SL                         SHICGG+LI ++WI+TA HC  Y+ SP      +++   LGAY +S  S H I+  +D +I   NS      + D A++ L++ + +T YI P CLP T+   T G  C+  GWGT  S  E  NL   ++    ++ P++  AT       +S       + +IC    +G    C+GDSGGPL+CQ +   W  +GI   G GC  +    ++T V  Y  +++   N
Sbjct:   36 RIVGGTDATDGAWPWQVSLDY---------------------HGSHICGGSLIATQWIMTAAHCFEYSKSP------SDYKIRLGAYQLSLISPHEITSTVDSIIV--NSPNSSSTNTDIALIRLTSPITYTKYILPICLPSTSDGFTEGMECWVTGWGTIASQGE-VNLPYPMTL-QQVMTPLISRATCNQMYNTDSLLSVVVPLDQICAGYAAGQKDSCQGDSGGPLVCQLQG-IWYQIGIVSWGEGCAVRNRPGVYTLVPAYYSWVIAEEN 277
[Close]
BLAST of Serine protease hepsin vs. Ensembl Xenopus
Match: fus (FUS RNA binding protein [Source:Xenbase;Acc:XB-GENE-495119])

HSP 1 Score: 125.561 bits (314), Expect = 1.813e-30
Identity = 85/296 (28.72%), Postives = 139/296 (46.96%), Query Frame = 2 
Query:  266 NTKIINRYRRIVSGVNSYYGEWPWIASLKNPVLKELIEKYAPTYMNWSLVGSDSHICGGTLINSEWIVTAQHCLYYNFSPQAIAITANWSATLGAYDISGYSQHSISIKIDKVIFQENSFGMDLDDNDFAMMHLSTAVNFTDYIYPACLPTNPLATPGNI-CYAVGWGTSYSLNETTNLDDGLSPGHALVNPILKHATLLIRERKESKACNTQ-----TVKE--ICTSPLSGSV--CRGDSGGPLLCQGE-NQSWIFVGITVRGSGCQKKTDRSIFTSVYHYLDFLVQTMNHSPKN 1120
            N  + N+  RIV G NS  G+WPW+ S+++P  KE                  SH+CGG+++N  W++TA HC  +    Q +   AN    L         + S+ I+  K + Q  ++    + ND  ++ L   + FTDY+ PAC PT          CY  GWG    L+E +       P       IL+ A +    + +SK CN++      + E  +C     G +  C+GDSGGPL+C+ + ++++  VGIT  GSGC +     ++TS  +++ ++   +    K 
Sbjct:   26 NRPLFNKGSRIVGGQNSPPGKWPWMVSIQSPTGKEF-----------------SHLCGGSVLNEIWVLTAAHCFKHL---QRLVFGANNLKVL---------ESSVQIRKIKEVIQPKAYNPTTEANDITLLRLDKPIVFTDYVQPACFPTEFANVEKKTDCYIAGWGV---LDEESG-----EPSE-----ILQEARV---HQIDSKKCNSKDWYDGAIGEYNLCAGHEKGGIDSCQGDSGGPLMCKTQKSRTYAVVGITSWGSGCARGKKPGVYTSTKYFIKWIASKVETDEKE 276
[Close]
BLAST of Serine protease hepsin vs. Ensembl Mouse
Match: Tmprss15 (transmembrane protease, serine 15 [Source:MGI Symbol;Acc:MGI:1197523])

HSP 1 Score: 121.709 bits (304), Expect = 1.082e-27
Identity = 82/273 (30.04%), Postives = 124/273 (45.42%), Query Frame = 2 
Query:  293 RIVSGVNSYYGEWPWIASLKNPVLKELIEKYAPTYMNWSLVGSDSHICGGTLINSEWIVTAQHCLYY-NFSPQAIAITANWSATLGAYDISGYSQHSISIKIDKVIFQENSFGMDLDDNDFAMMHLSTAVNFTDYIYPACLP-TNPLATPGNICYAVGWGTSYSLNETTNLDDGLSPGHALVNPILKHATL-LIRERKESKACNTQTVKE--ICTSPLSGSV--CRGDSGGPLLCQGENQSWIFVGITVRGSGCQKKTDRSIFTSVYHYLDFL 1090
            +IV G ++  G WPW+ +L +                     +D  +CG +L++S+W+V+A HC+Y  N  P        W+A LG +  S  +   +  ++   I     +      ND AMMHL   VN+TDYI P CLP  N +  PG  C   GWG    +N  + +D            +LK A + LI   K  +      + E  IC     G +  C+GDSGGPL+CQ EN  W  VG+T  G  C       ++  V  +++++
Sbjct:  814 KIVGGSDAQAGAWPWVVALYH-----------------RDRSTDRLLCGASLVSSDWLVSAAHCVYRRNLDP------TRWTAVLGLHMQSNLTSPQVVRRVVDQIVINPHYDRRRKVNDIAMMHLEFKVNYTDYIQPICLPEENQIFIPGRTCSIAGWGYD-KINAGSTVD------------VLKEADVPLISNEKCQQQLPEYNITESMICAGYEEGGIDSCQGDSGGPLMCQ-ENNRWFLVGVTSFGVQCALPNHPGVYVRVSQFIEWI 1049
[Close]
BLAST of Serine protease hepsin vs. Ensembl Mouse
Match: Tmprss15 (transmembrane protease, serine 15 [Source:MGI Symbol;Acc:MGI:1197523])

HSP 1 Score: 121.709 bits (304), Expect = 1.135e-27
Identity = 82/273 (30.04%), Postives = 124/273 (45.42%), Query Frame = 2 
Query:  293 RIVSGVNSYYGEWPWIASLKNPVLKELIEKYAPTYMNWSLVGSDSHICGGTLINSEWIVTAQHCLYY-NFSPQAIAITANWSATLGAYDISGYSQHSISIKIDKVIFQENSFGMDLDDNDFAMMHLSTAVNFTDYIYPACLP-TNPLATPGNICYAVGWGTSYSLNETTNLDDGLSPGHALVNPILKHATL-LIRERKESKACNTQTVKE--ICTSPLSGSV--CRGDSGGPLLCQGENQSWIFVGITVRGSGCQKKTDRSIFTSVYHYLDFL 1090
            +IV G ++  G WPW+ +L +                     +D  +CG +L++S+W+V+A HC+Y  N  P        W+A LG +  S  +   +  ++   I     +      ND AMMHL   VN+TDYI P CLP  N +  PG  C   GWG    +N  + +D            +LK A + LI   K  +      + E  IC     G +  C+GDSGGPL+CQ EN  W  VG+T  G  C       ++  V  +++++
Sbjct:  829 KIVGGSDAQAGAWPWVVALYH-----------------RDRSTDRLLCGASLVSSDWLVSAAHCVYRRNLDP------TRWTAVLGLHMQSNLTSPQVVRRVVDQIVINPHYDRRRKVNDIAMMHLEFKVNYTDYIQPICLPEENQIFIPGRTCSIAGWGYD-KINAGSTVD------------VLKEADVPLISNEKCQQQLPEYNITESMICAGYEEGGIDSCQGDSGGPLMCQ-ENNRWFLVGVTSFGVQCALPNHPGVYVRVSQFIEWI 1064
[Close]
BLAST of Serine protease hepsin vs. Ensembl Mouse
Match: Klkb1 (kallikrein B, plasma 1 [Source:MGI Symbol;Acc:MGI:102849])

HSP 1 Score: 119.013 bits (297), Expect = 2.968e-27
Identity = 82/282 (29.08%), Postives = 131/282 (46.45%), Query Frame = 2 
Query:  293 RIVSGVNSYYGEWPWIASLKNPVLKELIEKYAPTYMNWSLVGSDSHICGGTLINSEWIVTAQHCLYYNFSPQAIAITANWSATLGAYDISGYSQHSISIKIDKVIFQENSFGMDLDDNDFAMMHLSTAVNFTDYIYPACLP----TNPLATPGNICYAVGWGTSYSLNETTNLDDGLSPGHALVNPILKHATLLIRERKESKACNTQTV---KEICTSPLSG--SVCRGDSGGPLLCQGENQSWIFVGITVRGSGCQKKTDRSIFTSVYHYLDFLVQTMNHS 1111
            RIV G N+  GEWPW  SL+  ++                  S +H+CGG++I  +W++TA HC         I     W    G   +S  ++ + S +I ++I  +  + +   + D A++ L T +N+T++  P CLP    TN + T    C+  GWG +    ET N              IL+ AT+ +   +E +      V   + IC     G    C+GDSGGPL+C+   + W  VGIT  G GC +K    ++T V  Y+D++++    S
Sbjct:  390 RIVGGTNASLGEWPWQVSLQVKLV------------------SQTHLCGGSIIGRQWVLTAAHCF------DGIPYPDVWRIYGGILSLSEITKETPSSRIKELIIHQE-YKVSEGNYDIALIKLQTPLNYTEFQKPICLPSKADTNTIYTN---CWVTGWGYTKEQGETQN--------------ILQKATIPLVPNEECQKKYRDYVINKQMICAGYKEGGTDACKGDSGGPLVCKHSGR-WQLVGITSWGEGCARKDQPGVYTKVSEYMDWILEKTQSS 628
[Close]
BLAST of Serine protease hepsin vs. Ensembl Mouse
Match: Prss30 (protease, serine 30 [Source:MGI Symbol;Acc:MGI:1353645])

HSP 1 Score: 112.079 bits (279), Expect = 1.543e-26
Identity = 78/282 (27.66%), Postives = 126/282 (44.68%), Query Frame = 2 
Query:  293 RIVSGVNSYYGEWPWIASLKNPVLKELIEKYAPTYMNWSLVGSDSHICGGTLINSEWIVTAQHCLYYNFSPQAIAITANWSATLGAYDISGYSQHSISIKIDKVIFQENSFGMDLDDNDFAMMHLSTAVNFTDYIYPACLPT--NPLATPGNICYAVGWGTSYSLNETTNLDDGLSPGHALVNPILKHATLLIRERKESKACNTQTVKE---ICTSPLSG--SVCRGDSGGPLLCQGENQSWIFVGITVRGSGCQKKTDRSIFTSVYHYLDFLVQTM--NHS 1111
            +IV G ++  G+WPW  SL                  W  +  D HICGG+LI+  W++TA HC   + +P      + +   +G   +S    HS  + +  +         D    D A++ L T +  + +  P CLP    PL TPG +C+  GWG +   +  + L +       L  P+L           +  + + + + +   +C   + G    C+GDSGGPL+C   N SW  VGIT  G GC +     ++T V  Y+D++ + +  NHS
Sbjct:   36 KIVGGQDALEGQWPWQVSL------------------W--ITEDGHICGGSLIHEVWVLTAAHCFRRSLNP------SFYHVKVGGLTLSLLEPHSTLVAVRNIFVHPTYLWADASSGDIALVQLDTPLRPSQFT-PVCLPAAQTPL-TPGTVCWVTGWGATQERDMASVLQE-------LAVPLLDSEDCEKMYHTQGSSLSGERIIQSDMLCAGYVEGQKDSCQGDSGGPLVCS-INSSWTQVGITSWGIGCARPYRPGVYTRVPTYVDWIQRILAENHS 281
[Close]
BLAST of Serine protease hepsin vs. Ensembl Mouse
Match: Prss30 (protease, serine 30 [Source:MGI Symbol;Acc:MGI:1353645])

HSP 1 Score: 112.079 bits (279), Expect = 1.543e-26
Identity = 78/282 (27.66%), Postives = 126/282 (44.68%), Query Frame = 2 
Query:  293 RIVSGVNSYYGEWPWIASLKNPVLKELIEKYAPTYMNWSLVGSDSHICGGTLINSEWIVTAQHCLYYNFSPQAIAITANWSATLGAYDISGYSQHSISIKIDKVIFQENSFGMDLDDNDFAMMHLSTAVNFTDYIYPACLPT--NPLATPGNICYAVGWGTSYSLNETTNLDDGLSPGHALVNPILKHATLLIRERKESKACNTQTVKE---ICTSPLSG--SVCRGDSGGPLLCQGENQSWIFVGITVRGSGCQKKTDRSIFTSVYHYLDFLVQTM--NHS 1111
            +IV G ++  G+WPW  SL                  W  +  D HICGG+LI+  W++TA HC   + +P      + +   +G   +S    HS  + +  +         D    D A++ L T +  + +  P CLP    PL TPG +C+  GWG +   +  + L +       L  P+L           +  + + + + +   +C   + G    C+GDSGGPL+C   N SW  VGIT  G GC +     ++T V  Y+D++ + +  NHS
Sbjct:   36 KIVGGQDALEGQWPWQVSL------------------W--ITEDGHICGGSLIHEVWVLTAAHCFRRSLNP------SFYHVKVGGLTLSLLEPHSTLVAVRNIFVHPTYLWADASSGDIALVQLDTPLRPSQFT-PVCLPAAQTPL-TPGTVCWVTGWGATQERDMASVLQE-------LAVPLLDSEDCEKMYHTQGSSLSGERIIQSDMLCAGYVEGQKDSCQGDSGGPLVCS-INSSWTQVGITSWGIGCARPYRPGVYTRVPTYVDWIQRILAENHS 281
[Close]
BLAST of Serine protease hepsin vs. UniProt/SwissProt
Match: sp|P98072|ENTK_BOVIN (Enteropeptidase OS=Bos taurus OX=9913 GN=TMPRSS15 PE=1 SV=1)

HSP 1 Score: 124.79 bits (312), Expect = 7.381e-28
Identity = 89/303 (29.37%), Postives = 134/303 (44.22%), Query Frame = 2 
Query:  227 CGKQMI--EKSPQSNNTKIINRYRRIVSGVNSYYGEWPWIASLKNPVLKELIEKYAPTYMNWSLVGSDSHICGGTLINSEWIVTAQHCLY-YNFSPQAIAITANWSATLGAYDISGYSQHSISIKIDKVIFQENSFGMDLDDNDFAMMHLSTAVNFTDYIYPACLP-TNPLATPGNICYAVGWGTSYSLNETTNLDDGLSPGHALVNPILKHATL-LIRERKESKACNTQTVKE--ICTSPLSGSV--CRGDSGGPLLCQGENQSWIFVGITVRGSGCQKKTDRSIFTSVYHYLDFLVQTMNH 1108
            CGK+++  E SP            +IV G +S  G WPW+ +L               Y +      D  +CG +L++ +W+V+A HC+Y  N  P      + W A LG +  S  +   I  ++   I     +     +ND AMMHL   VN+TDYI P CLP  N +  PG IC   GWG       T +              +L+ A + L+   K  +      + E  +C    +G V  C+GDSGGPL+CQ EN  W+  G+T  G  C       ++  V  + ++ +Q+  H
Sbjct:  788 CGKKLVTQEVSP------------KIVGGSDSREGAWPWVVAL---------------YFD------DQQVCGASLVSRDWLVSAAHCVYGRNMEP------SKWKAVLGLHMASNLTSPQIETRLIDQIVINPHYNKRRKNNDIAMMHLEMKVNYTDYIQPICLPEENQVFPPGRICSIAGWGALIYQGSTAD--------------VLQEADVPLLSNEKCQQQMPEYNITENMVCAGYEAGGVDSCQGDSGGPLMCQ-ENNRWLLAGVTSFGYQCALPNRPGVYARVPRFTEW-IQSFLH 1035
[Close]
BLAST of Serine protease hepsin vs. UniProt/SwissProt
Match: sp|Q90WD8|OVCH2_BUFJA (Ovochymase-2 OS=Bufo japonicus OX=8387 GN=OVCH2 PE=1 SV=1)

HSP 1 Score: 122.094 bits (305), Expect = 4.700e-27
Identity = 98/355 (27.61%), Postives = 152/355 (42.82%), Query Frame = 2 
Query:  134 SEMNLNPILMIFISCSIKLFSGTKYNLTQIPCGKQMIEKSPQSNNTKIINRYRRIVSGVNSYYGEWPWIASLKNPVLKELIEKYAPTYMNWSLVGSDSHICGGTLINSEWIVTAQHC-LYYNFSPQAIAITANWSATLGAYDISGYSQHSISIKIDKVIFQENSFGMDLDDN-DFAMMHLSTAVNFTDYIYPACLPTNPLATP-GNICYAVGWGTSYSLNETTNLDDGLSPGHALVNPILKHATLLIRERKESKACNTQTVKEICTS-PLSG-SVCRGDSGGPLLCQGENQSWIFVGITVRGSGCQK------------KTDRSIFTSVYHYLDFLVQTMNHSPKNVKIPIYHLQ 1147
            +E ++ PI+M+ +        G    +T  P       + P +N +       RIV G ++  GE PW+ SLK                         H CGGT+I+ ++++TA HC L  NF  Q        S ++G +D + Y +      I K +F+  +F      N D A++ L  ++ F   I PACLP+     P G +C A+GWG    L E   L   L     +V P++++   L       +    +TV  +C   P  G   C+GDSGGP LCQ     W+ VG+T  G GC +            K    +FT +   L++L + +N    +   P Y +Q
Sbjct:    2 AETSIFPIMMLTV------MIGVGRGVTDSPGRVSRCGERPAANTSVSYGLLSRIVGGTSAVKGESPWMVSLKR---------------------DGKHFCGGTIISDKYVLTAAHCVLEKNFEFQV-------SVSIGDHDFAVYERSEQRFAI-KSVFKHPNFKPSRPFNYDLAILELVESITFDKDIQPACLPSPDDVFPTGTLCMALGWG---RLQENGRLPSSL---QKVVLPLIEYRRCLSIMETVDRRLAFETV--VCAGFPEGGKDACQGDSGGPFLCQRSQGRWVLVGVTSWGLGCARKWADNILDPVESKGSPGVFTDIQRLLNWLSENLNQDKPD--FPTYQVQ 311

HSP 2 Score: 67.0106 bits (162), Expect = 5.739e-10
Identity = 55/245 (22.45%), Postives = 107/245 (43.67%), Query Frame = 2 
Query:  377 EKYAPTYMNW--SLVGSDSHICGGTLINSEWIVTAQHCLYYNFSPQAIAITANWSATLGAYDISGYSQHSISIKIDKVIFQENSFGMDLDDNDFAMMHLSTAVNFTDYIYPACLPT-NPLATPGNICYAVGWGTSYSLNETTNLDDGLSPGHALVNPILKHATLLIRERKESKACNTQTVKEICTSPLSGSVCRGDSGGPLLCQGENQSWIFVGITVRGSGCQKKTDRSIFTSVYHYLDFLVQTM 1102
            E+  P    W  S+   + H+C G +++  ++VT+ +C+       +I +        G +D+   S ++    ++ VI   + +     D D A++H+     +  Y+ P CLP  +    P  +C   GW  +  L  +T L     P   L++ + K     I +R     C     +E        + C   SG PL+CQ    ++   GI  RG GC +     +++SV+ ++ ++++T+
Sbjct:  594 EEAMPNSWPWHVSINFGNKHVCNGAILSKTFVVTSANCVADREEFPSIGLI-----VAGLHDLES-SINTQKRPVEYVIVHPD-YNRLSKDYDVALIHVQRPFQYNSYVQPICLPDGHSRLEPSKLCVVSGWDLNVEL--STKLQQLEVP--VLMDDVCKKYYDGITDRM---FCAGVIAEE------DNASCLAQSGAPLVCQSAPGTYAIFGIVSRGVGCNETPKAGVYSSVFLFIPWIMETI 818
[Close]
BLAST of Serine protease hepsin vs. UniProt/SwissProt
Match: sp|P97435|ENTK_MOUSE (Enteropeptidase OS=Mus musculus OX=10090 GN=Tmprss15 PE=2 SV=1)

HSP 1 Score: 121.709 bits (304), Expect = 7.939e-27
Identity = 82/273 (30.04%), Postives = 124/273 (45.42%), Query Frame = 2 
Query:  293 RIVSGVNSYYGEWPWIASLKNPVLKELIEKYAPTYMNWSLVGSDSHICGGTLINSEWIVTAQHCLYY-NFSPQAIAITANWSATLGAYDISGYSQHSISIKIDKVIFQENSFGMDLDDNDFAMMHLSTAVNFTDYIYPACLP-TNPLATPGNICYAVGWGTSYSLNETTNLDDGLSPGHALVNPILKHATL-LIRERKESKACNTQTVKE--ICTSPLSGSV--CRGDSGGPLLCQGENQSWIFVGITVRGSGCQKKTDRSIFTSVYHYLDFL 1090
            +IV G ++  G WPW+ +L +                     +D  +CG +L++S+W+V+A HC+Y  N  P        W+A LG +  S  +   +  ++   I     +      ND AMMHL   VN+TDYI P CLP  N +  PG  C   GWG    +N  + +D            +LK A + LI   K  +      + E  IC     G +  C+GDSGGPL+CQ EN  W  VG+T  G  C       ++  V  +++++
Sbjct:  829 KIVGGSDAQAGAWPWVVALYH-----------------RDRSTDRLLCGASLVSSDWLVSAAHCVYRRNLDP------TRWTAVLGLHMQSNLTSPQVVRRVVDQIVINPHYDRRRKVNDIAMMHLEFKVNYTDYIQPICLPEENQIFIPGRTCSIAGWGYD-KINAGSTVD------------VLKEADVPLISNEKCQQQLPEYNITESMICAGYEEGGIDSCQGDSGGPLMCQ-ENNRWFLVGVTSFGVQCALPNHPGVYVRVSQFIEWI 1064
[Close]
BLAST of Serine protease hepsin vs. UniProt/SwissProt
Match: sp|P98073|ENTK_HUMAN (Enteropeptidase OS=Homo sapiens OX=9606 GN=TMPRSS15 PE=1 SV=3)

HSP 1 Score: 121.324 bits (303), Expect = 8.495e-27
Identity = 90/280 (32.14%), Postives = 127/280 (45.36%), Query Frame = 2 
Query:  293 RIVSGVNSYYGEWPWIASLKNPVLKELIEKYAPTYMNWSLVGSDSHICGGTLINSEWIVTAQHCLY-YNFSPQAIAITANWSATLGAYDISGY-SQHSISIKIDKVIFQENSFGMDLDDNDFAMMHLSTAVNFTDYIYPACLP-TNPLATPGNICYAVGWGTSYSLNETTNLDDGLSPGHALVNPILKHAT--LLIRERKESKACNTQ-TVKEICTSPLSGSV--CRGDSGGPLLCQGENQSWIFVGITVRGSGCQKKTDRSIFTSVYHYLDFLVQTMNH 1108
            +IV G N+  G WPW+  L               Y    L      +CG +L++S+W+V+A HC+Y  N  P      + W+A LG +  S   S  ++   ID+++   + +     DND AMMHL   VN+TDYI P CLP  N +  PG  C   GWGT      T N              IL+ A   LL  ER + +      T   IC     G +  C+GDSGGPL+CQ EN  W   G+T  G  C       ++  V  + ++ +Q+  H
Sbjct:  784 KIVGGSNAKEGAWPWVVGL---------------YYGGRL------LCGASLVSSDWLVSAAHCVYGRNLEP------SKWTAILGLHMKSNLTSPQTVPRLIDEIVINPH-YNRRRKDNDIAMMHLEFKVNYTDYIQPICLPEENQVFPPGRNCSIAGWGTVVYQGTTAN--------------ILQEADVPLLSNERCQQQMPEYNITENMICAGYEEGGIDSCQGDSGGPLMCQ-ENNRWFLAGVTSFGYKCALPNRPGVYARVSRFTEW-IQSFLH 1019
[Close]
BLAST of Serine protease hepsin vs. UniProt/SwissProt
Match: sp|P14272|KLKB1_RAT (Plasma kallikrein OS=Rattus norvegicus OX=10116 GN=Klkb1 PE=1 SV=1)

HSP 1 Score: 119.783 bits (299), Expect = 1.221e-26
Identity = 86/286 (30.07%), Postives = 132/286 (46.15%), Query Frame = 2 
Query:  293 RIVSGVNSYYGEWPWIASLKNPVLKELIEKYAPTYMNWSLVGSDSHICGGTLINSEWIVTAQHCLYYNFSPQAIAITANWSATLGAYDISGYSQHSISIKIDKVIFQENSFGMDLDDNDFAMMHLSTAVNFTDYIYPACLP----TNPLATPGNICYAVGWGTSYSLNETTNLDDGLSPGHALVNPILKHAT--LLIRERKESKACNTQTVKE-ICTSPLSGSV--CRGDSGGPLLCQGENQSWIFVGITVRGSGCQKKTDRSIFTSVYHYLDFLVQTMNHSPKNV 1123
            RIV G NS  GEWPW  SL+  ++                  S +H+CGG++I  +WI+TA HC         I     W    G  ++S  +  +    I ++I  +  + M     D A++ L T +N+T++  P CLP    TN + T    C+  GWG +    ET N              IL+ AT  L+  E  + K  +    K+ IC     G +  C+GDSGGPL+C+   + W  VGIT  G GC +K    ++T V  Y+D++++ +  S +  
Sbjct:  390 RIVGGTNSSLGEWPWQVSLQVKLV------------------SQNHMCGGSIIGRQWILTAAHCF------DGIPYPDVWRIYGGILNLSEITNKTPFSSIKELIIHQK-YKMSEGSYDIALIKLQTPLNYTEFQKPICLPSKADTNTIYTN---CWVTGWGYTKERGETQN--------------ILQKATIPLVPNEECQKKYRDYVITKQMICAGYKEGGIDACKGDSGGPLVCKHSGR-WQLVGITSWGEGCARKEQPGVYTKVAEYIDWILEKIQSSKERA 632
[Close]
BLAST of Serine protease hepsin vs. TrEMBL
Match: A0A075A3B0 (Uncharacterized protein OS=Opisthorchis viverrini OX=6198 GN=T265_01217 PE=4 SV=1)

HSP 1 Score: 345.895 bits (886), Expect = 9.421e-109
Identity = 169/329 (51.37%), Postives = 221/329 (67.17%), Query Frame = 2 
Query: 1322 MVSIQYGGGPTIEQQRAFCNPPEGSHIPGYLGFIPQAKFEVGKTFARESHDVARKLPYYNGPRNASVKHFYPEVGKTKDCENRSIFQDEFPKNKLPIPTGDNKYTEKMMPGYSGDIPHWNYKFGGTYRSICDEAVNEFITDYERNEAKMNDIKKMASMFPKLRPICSDLRVKDHMNLWSDNLTKMSTLASDRRHILEPPIPGYTGFVPRKDNTEVGLGNRYHEAAKHCFESFVTENSRHFQKLEEPMKVKNNTYTVQDQKSLVVSVPSKVAYSRRIFVQDGMIPGYTGHLHEEKDVDGYTYGDSSRTLKVSQHSFPCYGDYIKNIDLAA 2308
            M SI+YGGGP++EQ+R FCN PEG+ IPGY+GF PQ K+  G T+ RE+ D+A++LPYYNGP+     H YP VG  KD   RS F+DE P   LP PTGDNKY   M+PGYSGD+PH  +KFG TYR   DE V+EF+  Y+  E K  +++++A +FP LRPI  D RV++H+NLW+D+L+K +T AS  R   +PPIPGY GFVP  D TE GL  R+HEAAK   E+F TEN  H+ +L EP    N    V+D     V  P+++  S RIF Q+GMIP Y GH+H  K   G  +G+++R L+V  H FP YGDY+K  D+A+
Sbjct:    1 MTSIEYGGGPSLEQRRKFCNLPEGAQIPGYMGFCPQLKYRSGHTYGRETADIAQELPYYNGPQIQKPHHLYPVVGDYKDATARSAFRDEVPGKMLPQPTGDNKYIAGMIPGYSGDVPHMPFKFGATYRQTADECVDEFVRKYKCEEKKREELREVAGIFPALRPIALDPRVRNHLNLWADDLSKKNTTASAVRGPTDPPIPGYMGFVPCMDTTEAGLAKRFHEAAKSGLETFRTENQAHWDRLAEPTTTVNTEPVVKDT---FVRQPNELFNSSRIFRQEGMIPEYKGHIHGYKFHVGKNFGNTTRDLEVCAHPFPSYGDYVKERDIAS 326
[Close]
BLAST of Serine protease hepsin vs. TrEMBL
Match: A0A4S2M5Y2 (Uncharacterized protein OS=Opisthorchis felineus OX=147828 GN=CRM22_002492 PE=4 SV=1)

HSP 1 Score: 340.887 bits (873), Expect = 7.457e-107
Identity = 167/329 (50.76%), Postives = 221/329 (67.17%), Query Frame = 2 
Query: 1322 MVSIQYGGGPTIEQQRAFCNPPEGSHIPGYLGFIPQAKFEVGKTFARESHDVARKLPYYNGPRNASVKHFYPEVGKTKDCENRSIFQDEFPKNKLPIPTGDNKYTEKMMPGYSGDIPHWNYKFGGTYRSICDEAVNEFITDYERNEAKMNDIKKMASMFPKLRPICSDLRVKDHMNLWSDNLTKMSTLASDRRHILEPPIPGYTGFVPRKDNTEVGLGNRYHEAAKHCFESFVTENSRHFQKLEEPMKVKNNTYTVQDQKSLVVSVPSKVAYSRRIFVQDGMIPGYTGHLHEEKDVDGYTYGDSSRTLKVSQHSFPCYGDYIKNIDLAA 2308
            M SI+YGGGP++EQ+R FCN P+G+ IPGY+GF PQ K+  G T+ RE+ D+A++LPYYNGP+     H YP VG  KD   RS+F+DE P   LP PTGDNKY   M+PGYSGD+PH  +KFG TYR   DE V+EF+  Y+  E K  +++++A +FP LRPI  D RV++H+NLW+D+L+K +T AS  R   +PPIPGY GFVP  D TE GL  R+HEAAK   E+F TEN  H+ +L E     N    V+D     V  P+++  S RIF Q+GMIP Y GH+H  K   G  +G+++R L+V  H FP YGDY+K  D+A+
Sbjct:    1 MTSIEYGGGPSLEQRRKFCNVPDGAQIPGYMGFCPQLKYRSGHTYGRETADIAQELPYYNGPQIQKPHHLYPIVGDDKDATVRSVFRDEVPGKMLPQPTGDNKYIAGMIPGYSGDVPHMPFKFGATYRQTADECVDEFVRKYKCEEKKREELREVAGIFPALRPIALDPRVRNHLNLWADDLSKKNTTASAVRGPSDPPIPGYMGFVPCMDTTEAGLAKRFHEAAKSGLETFRTENQAHWDRLAEHTTTVNTEPVVRDT---FVRRPNELFNSSRIFRQEGMIPEYKGHIHGYKFHVGKNFGNTTRDLEVCAHPFPSYGDYVKERDIAS 326
[Close]
BLAST of Serine protease hepsin vs. TrEMBL
Match: A0A504YZT8 (Uncharacterized protein OS=Fasciola gigantica OX=46835 GN=FGIG_08686 PE=4 SV=1)

HSP 1 Score: 321.627 bits (823), Expect = 1.670e-99
Identity = 153/329 (46.50%), Postives = 209/329 (63.53%), Query Frame = 2 
Query: 1322 MVSIQYGGGPTIEQQRAFCNPPEGSHIPGYLGFIPQAKFEVGKTFARESHDVARKLPYYNGPRNASVKHFYPEVGKTKDCENRSIFQDEFPKNKLPIPTGDNKYTEKMMPGYSGDIPHWNYKFGGTYRSICDEAVNEFITDYERNEAKMNDIKKMASMFPKLRPICSDLRVKDHMNLWSDNLTKMSTLASDRRHILEPPIPGYTGFVPRKDNTEVGLGNRYHEAAKHCFESFVTENSRHFQKLEEPMKVKNNTYTVQDQKSLVVSVPSKVAYSRRIFVQDGMIPGYTGHLHEEKDVDGYTYGDSSRTLKVSQHSFPCYGDYIKNIDLAA 2308
            MVSI+YGGGPT+EQ+R FCN  EG HIPGY+GF PQ  ++ G ++ + + ++A  L YYNGP+     H  P V   K+   RS+F+DE P   LP  TGDNKY   M+PGYSGD+PH  +KFG TYR   DE V+EF+ +Y+ +EAK  ++++++ +FP LR + +D RV++HMN+WSD L K +      R   +PPIPGY GF+PR   TE GL  RYHE A    E+F  +   HF +L +P+    +T  V D KS    +PS    S RIF ++GMIP Y GH+H  K   G  +G+ +R L+V  H FP YGDY++  DLA+
Sbjct:    1 MVSIEYGGGPTLEQRREFCNLEEGGHIPGYMGFCPQLNYQCGNSYGKTTAEIAANLSYYNGPQTQKPHHLRPTVSDDKNASVRSVFRDEVPGRMLPESTGDNKYIAGMIPGYSGDVPHLAFKFGTTYRETTDECVDEFVREYKCHEAKREELREISGLFPTLRAVSNDPRVRNHMNIWSDELRKNNATVRPIRGPTDPPIPGYQGFIPRMQTTEAGLAKRYHEGAHQSLEAFRAQTQGHFDRLAQPI-TSIDTSPVVDSKS--PQIPSDKYVSSRIFRKEGMIPDYNGHVHGLKFQVGKNFGNITRDLEVCAHPFPSYGDYVREKDLAS 326
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BLAST of Serine protease hepsin vs. TrEMBL
Match: H2KV50 (Protein FAM166B (Fragment) OS=Clonorchis sinensis OX=79923 GN=CLF_111257 PE=4 SV=1)

HSP 1 Score: 309.686 bits (792), Expect = 2.150e-95
Identity = 148/300 (49.33%), Postives = 198/300 (66.00%), Query Frame = 2 
Query: 1409 YLGFIPQAKFEVGKTFARESHDVARKLPYYNGPRNASVKHFYPEVGKTKDCENRSIFQDEFPKNKLPIPTGDNKYTEKMMPGYSGDIPHWNYKFGGTYRSICDEAVNEFITDYERNEAKMNDIKKMASMFPKLRPICSDLRVKDHMNLWSDNLTKMSTLASDRRHILEPPIPGYTGFVPRKDNTEVGLGNRYHEAAKHCFESFVTENSRHFQKLEEPMKVKNNTYTVQDQKSLVVSVPSKVAYSRRIFVQDGMIPGYTGHLHEEKDVDGYTYGDSSRTLKVSQHSFPCYGDYIKNIDLAA 2308
            Y+GF PQ K+  G T+ RE+ D+A++LPYYNGP+     H YP VG  KD   RS+F+DE P   LP PTGDNKY   M+PGYSGD+PH  +KFG TYR   DE V+EF+  Y+  E K ++++++A +FP LRPI  D R+++H+NLW+D+L+K +T AS  R   +PPIPGY GFVP  D TE GL  R+HEAAK   E+F TEN  H+ +L EP    N    V+D     V  P+++  S RIF Q+GMIP Y GH+H  K   G  +G+++R L+V  H FP YGDY+K  D+A+
Sbjct:    1 YMGFCPQLKYRSGHTYGRETADIAQELPYYNGPQVQKPHHLYPVVGDYKDATVRSVFRDEVPGKMLPQPTGDNKYIAGMIPGYSGDVPHMPFKFGATYRQTADECVDEFVRKYKCEEKKRDELREVAGIFPALRPIAIDPRIRNHLNLWADDLSKKNTTASAVRGPTDPPIPGYMGFVPCMDTTEAGLAKRFHEAAKSGLETFRTENQAHWDRLAEPTTTANTEPVVKDT---FVRRPTELFNSSRIFRQEGMIPEYKGHIHGYKFHVGKNFGNTTRDLEVCAHPFPSYGDYVKERDIAS 297
[Close]
BLAST of Serine protease hepsin vs. TrEMBL
Match: A0A4E0R8U7 (Uncharacterized protein OS=Fasciola hepatica OX=6192 GN=D915_007135 PE=4 SV=1)

HSP 1 Score: 308.916 bits (790), Expect = 2.345e-94
Identity = 149/343 (43.44%), Postives = 207/343 (60.35%), Query Frame = 2 
Query: 1322 MVSIQYGGGPTIEQQRAFCNPPEGSHIPGYLGFIPQAKFEVGKTFARESHDVA--------------RKLPYYNGPRNASVKHFYPEVGKTKDCENRSIFQDEFPKNKLPIPTGDNKYTEKMMPGYSGDIPHWNYKFGGTYRSICDEAVNEFITDYERNEAKMNDIKKMASMFPKLRPICSDLRVKDHMNLWSDNLTKMSTLASDRRHILEPPIPGYTGFVPRKDNTEVGLGNRYHEAAKHCFESFVTENSRHFQKLEEPMKVKNNTYTVQDQKSLVVSVPSKVAYSRRIFVQDGMIPGYTGHLHEEKDVDGYTYGDSSRTLKVSQHSFPCYGDYIKNIDLAA 2308
            MVSI+YGGGPT+EQ+R FCN  EG HIPGY+GF PQ  ++ G ++ + + ++A              + L YYNGP+     H  P V   K+   RS+F+DE P   LP  TGDNKY   M+PGYSGD+PH  +KFG TYR   DE V+EF+ +Y+ +EAK  ++++++ +FP LR + +D RV++HMN+WSD L K +      R   +PPIPGY GF+PR   TE GL  RYHE A    E F  +   HF +L +P+   + +  V  +      +PS    S RIF ++GMIP Y GH+H  K   G  +G+ +R L+V  H FP YGDY++  DLA+
Sbjct:    1 MVSIEYGGGPTLEQRREFCNLEEGGHIPGYMGFCPQLNYQCGNSYGKTTAEIAAVSCNHRNDDCNLSQNLSYYNGPQTQKPHHLRPTVSDDKNASVRSVFRDEVPGRMLPESTGDNKYIAGMIPGYSGDVPHLAFKFGTTYRETTDECVDEFVREYKCHEAKREELREISGLFPTLRAVSNDPRVRNHMNIWSDELRKNNATVRPIRGPTDPPIPGYQGFIPRMQTTEAGLAKRYHEGAHQSLEVFRAQTQGHFDRLAQPITSIDTSPIVDSKPP---QIPSDKYVSSRIFRKEGMIPDYNGHVHGLKFQVGKNFGNITRDLEVCAHPFPSYGDYVREKDLAS 340
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BLAST of Serine protease hepsin vs. Ensembl Cavefish
Match: tmprss5 (transmembrane serine protease 5 [Source:ZFIN;Acc:ZDB-GENE-131121-184])

HSP 1 Score: 123.635 bits (309), Expect = 8.565e-31
Identity = 92/283 (32.51%), Postives = 137/283 (48.41%), Query Frame = 2 
Query:  293 RIVSGVNSYYGEWPWIASLKNPVLKELIEKYAPTYMNWSLVGSDSHICGGTLINSEWIVTAQHCLYY-----NFSPQAIAITANWSATLGAYDISGYSQHSISIKIDKVIFQENSFGMDLDDNDFAMMHLSTAVNFTDYIYPACLPTNPLATPGNI-CYAVGWGTSYSLNETTNLDDGLSPGHALVNPILKHATL-LIRERKESKAC---NTQTVKEICTSPLSGSV--CRGDSGGPLLCQGENQSWIFVGITVRGSGCQKKTDRSIFTSVYHYLDFLVQTMN 1105
            RIV GV +  G WPW  SL                       S+ H CGG++I S+WIVTA HC+Y      ++   A  +T N +A L  Y  +GY+       ++K+I+ +N +     DND A+M L T +NF+D I PACLP      PG   C+  GWG  Y+  +  ++ D            LK A + LI  +K + +C      T + +C     G V  C+GDSGGPL+CQ +N  W  VG+   G+GC +     ++T V  +L ++ + + 
Sbjct:   30 RIVGGVEATPGRWPWQVSLYY---------------------SNRHTCGGSIITSQWIVTAAHCVYRLPQVSSWVVYAGIVTRN-TAKLAQY--TGYA-------VEKIIYNKN-YNHRSHDNDIALMKLRTPLNFSDTIRPACLPQYDHDLPGGTQCWISGWG--YTQPDDVHIPD-----------TLKEAPVPLISTKKCNSSCMYNGEITSRMLCAGYTEGKVDACQGDSGGPLVCQDDN-VWRLVGVVSWGTGCAEPNHPGVYTKVAEFLGWIYEMIE 266
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BLAST of Serine protease hepsin vs. Ensembl Cavefish
Match: ENSAMXT00000033802.1 (pep primary_assembly:Astyanax_mexicanus-2.0:3:21891941:21894733:1 gene:ENSAMXG00000030254.1 transcript:ENSAMXT00000033802.1 gene_biotype:protein_coding transcript_biotype:protein_coding)

HSP 1 Score: 115.931 bits (289), Expect = 3.596e-28
Identity = 78/280 (27.86%), Postives = 124/280 (44.29%), Query Frame = 2 
Query:  281 NRYRRIVSGVNSYYGEWPWIASLKNPVLKELIEKYAPTYMNWSLVGSDSHICGGTLINSEWIVTAQHCLYYNFSPQAIAITANWSATLGAYDISGYSQHSISIKIDKVIFQENSFGMDLDDNDFAMMHLSTAVNFTDYIYPACLPTNPLA-TPGNICYAVGWGTSYSLNETTNLDDGLSPGHALVNPILKHATLLIRERKESKACNTQ-----TVKEICTSPLSGSV--CRGDSGGPLLCQGENQSWIFVGITVRGSGCQKKTDRSIFTSVYHYLDFLVQ 1096
             +  +IV G ++  G WPW  SL+       +E+Y              H+CG +L+ + W+++A HC  +  S    +    W A LG   ++  S  + + +I +++ Q   +     D D A++ LS  V F D + P C+P    A T G  C+  GWG    L E              +  +L+ AT+ I      K CN       T + IC   + G V  C+GDSGGPL+C    + W   GI   G GC ++    ++T V  + D++ Q
Sbjct:   48 RKRAKIVGGTDAQAGSWPWQVSLQ-------MERYG-------------HVCGASLVGTRWLLSAAHC--FQDSDAIYSDARAWRAFLGMRVMNTASNAAATRQIRRIV-QHAQYDQFTSDYDIALLELSAPVFFNDLVQPVCVPAPSHAFTSGTTCFVTGWGV---LTEEE------------LATLLQEATVSI---ISHKTCNKMYDDAVTPRMICAGNIQGGVDACQGDSGGPLVCLERGRRWFLAGIVSWGEGCARQNRPGVYTQVIKFTDWIHQ 286
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BLAST of Serine protease hepsin vs. Ensembl Cavefish
Match: ENSAMXT00000048530.1 (pep primary_assembly:Astyanax_mexicanus-2.0:13:20283923:20290642:1 gene:ENSAMXG00000040955.1 transcript:ENSAMXT00000048530.1 gene_biotype:protein_coding transcript_biotype:protein_coding)

HSP 1 Score: 114.775 bits (286), Expect = 5.723e-28
Identity = 79/288 (27.43%), Postives = 126/288 (43.75%), Query Frame = 2 
Query:  260 SNNTKIINRYRRIVSGVNSYYGEWPWIASLKNPVLKELIEKYAPTYMNWSLVGSDSHICGGTLINSEWIVTAQHCLYYN--FSPQAIAITANWSATLGAYDISGYSQHSISIKIDKVIFQENSFGMDLDDNDFAMMHLSTAVNFTDYIYPACLPTNP-LATPGNICYAVGWGTSYSLNETTNLDDGLSPGHALVNPILKHATLLIRERKESKACN-TQTVKEICTSPLSGS--VCRGDSGGPLLCQGENQSWIFVGITVRGSGCQKKTDRSIFTSVYHYLDFLVQTMN 1105
            S+N  + +   R+V G ++  GEWPW ASL+                      S  HICGG LI S+W+V+A HC Y +  +SP        W+  LG   + G SQ   ++++  +   +  +  +  D D A++ L   V+      PACLP++     PG +C+  GWG      E               N + K    L+ E    ++     T + +C    SG    C+GDSGGPL+CQ  +  W   G+   G GC +     ++T +    D++ Q ++
Sbjct:   17 SHNCGLRHFTTRVVGGADAVEGEWPWQASLQV---------------------SGRHICGGALIASQWVVSAAHCFYDDRLYSPSV------WTVYLGKLRLRGTSQTEEALRLSHIHIHQY-YDDENHDYDLALLRLDRPVSAGTLAQPACLPSHTHQLEPGLLCWVTGWGAMKEGGEKRGPS----------NVLQKVDVRLVSEEACVRSYGYIITPRMLCAGYRSGGKDACQGDSGGPLVCQEPSGRWFLAGVVSWGRGCGRPDYYGVYTRITRLSDWIKQVIS 266
[Close]
BLAST of Serine protease hepsin vs. Ensembl Cavefish
Match: tmprss5 (transmembrane serine protease 5 [Source:ZFIN;Acc:ZDB-GENE-131121-184])

HSP 1 Score: 118.242 bits (295), Expect = 7.530e-28
Identity = 91/284 (32.04%), Postives = 130/284 (45.77%), Query Frame = 2 
Query:  293 RIVSGVNSYYGEWPWIASLKNPVLKELIEKYAPTYMNWSLVGSDSHICGGTLINSEWIVTAQHCLYYNFSPQ-------AIAITANWSATLGAYDISGYSQHSISIKIDKVIFQENSFGMDLDDNDFAMMHLSTAVNFTDYIYPACLPTNPLATPGNI-CYAVGWGTSYSLNETTNLDDGLSPGHALVNPILKHATLLIRERKESKAC---NTQTVKEICTSPLSGSV--CRGDSGGPLLCQGENQSWIFVGITVRGSGCQKKTDRSIFTSVYHYLDFLVQTMN 1105
            RIV GV +  G WPW  SL                       S+ H CGG++I S+WIVTA HC++    PQ       A  +T N +A L  Y  +GY+       ++K+I+ +N +     DND A+M L T +NF+D I PACLP      PG   C+  GWG        T  DD                  LI  +K + +C      T + +C     G V  C+GDSGGPL+CQ +N  W  VG+   G+GC +     ++T V  +L ++ + + 
Sbjct:  191 RIVGGVEATPGRWPWQVSLYY---------------------SNRHTCGGSIITSQWIVTAAHCVHNYRLPQVSSWVVYAGIVTRN-TAKLAQY--TGYA-------VEKIIYNKN-YNHRSHDNDIALMKLRTPLNFSDTIRPACLPQYDHDLPGGTQCWISGWG-------YTQPDD----------------VPLISTKKCNSSCMYNGEITSRMLCAGYTEGKVDACQGDSGGPLVCQDDN-VWRLVGVVSWGTGCAEPNHPGVYTKVAEFLGWIYEMIE 418
[Close]
BLAST of Serine protease hepsin vs. Ensembl Cavefish
Match: si:dkey-32n7.9 (chymotrypsin-like protease CTRL-1 [Source:NCBI gene;Acc:103029386])

HSP 1 Score: 115.546 bits (288), Expect = 1.039e-27
Identity = 79/255 (30.98%), Postives = 114/255 (44.71%), Query Frame = 2 
Query:  293 RIVSGVNSYYGEWPWIASLKNPVLKELIEKYAPTYMNWSLVGSDSHICGGTLINSEWIVTAQHCLYYNFSPQAIAITANWSATLGAYDISGYSQHSISIKIDKVIFQENSFGMDLDDNDFAMMHLSTAVNFTDYIYPACLPTNPLATPGN-ICYAVGWGTSYSLNETTNLDDGLSPGHALVNPILKHATLLIRERKESKACNTQTVKE-------ICTSPLSGSVCRGDSGGPLLCQGENQSWIFVGITVRGSGC 1033
            RIV G N+  G WPW  S+ +                      D HICGGTLI+ EW++TA HC+           T+NW   LG  + S  + + +S  + ++I    S+   L +ND  +M LS+ VNF+DYI P CL +N      N  C++ GWG              L    +L +  L+   + +    +  ACN Q  K+       IC        C+GDSGGPL C+ +   W+  G+T  G  C
Sbjct:   36 RIVGGANAQAGNWPWQVSMHH---------------------QDQHICGGTLIHQEWVLTAAHCILS-------LDTSNWMLYLGRENQSTANPNEVSRGVQEIIMHP-SYNNTLFNNDVTLMRLSSPVNFSDYIRPICLASNSSTFYSNTTCWSTGWGL-------------LRHNESLASETLQEVEVPVVGNSQC-ACNYQVAKDANITAQMICAGSAGKGTCQGDSGGPLQCK-QGSVWVQAGVTSYGISC 246
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BLAST of Serine protease hepsin vs. Ensembl Sea Lamprey
Match: ENSPMAT00000006128.1 (pep scaffold:Pmarinus_7.0:GL484169:9759:12797:-1 gene:ENSPMAG00000005545.1 transcript:ENSPMAT00000006128.1 gene_biotype:protein_coding transcript_biotype:protein_coding)

HSP 1 Score: 112.849 bits (281), Expect = 3.079e-28
Identity = 81/273 (29.67%), Postives = 124/273 (45.42%), Query Frame = 2 
Query:  293 RIVSGVNSYYGEWPWIASLKNPVLKELIEKYAPTYMNWSLVGSDSHICGGTLINSEWIVTAQHCLYYNFSPQAIAITANWSATLGA---YDISGYSQHSISIKIDKVIFQENSFGMDLDDNDFAMMHLSTAVNFTDYIYPACLP--TNPLATPGNICYAVGWGTSYSLNETTNLDDGLSPGHALVNPILKHATLLIRERKESKACNTQTVKEICTSPLSGSV--CRGDSGGPLLCQGENQSWIFVGITVRGSGCQKKTDRSIFTSVYHYLDFL 1090
            RIV G  +  G+WPW ASL+N                       SH+CG +LI+  W+V A HC  Y+ +         W   LG    YD    S +++ + + ++I  E  F +   D D A++ LS  V+F   + P CLP  T+    PG  C+  GWG + SL E+    D L     + +     + L+          N  T + IC    +G++  C+GDSGGPL CQG +++W   G+T  G GC       ++T    +L ++
Sbjct:   15 RIVGGTPATSGKWPWQASLRN---------------------YGSHVCGASLISERWLVAAAHCFMYSSN------VYEWQVYLGITYIYD----SANAVIVNVAEIITHER-FNISTIDYDIALVRLSDPVSFNHRVSPICLPPSTSHFPQPGKTCFISGWGRT-SLAESGIHYDLLEAPMQIFSHEACSSNLM--------NGNFITTRMICIGHPAGAISSCQGDSGGPLACQGTDKAWYLSGVTSWGFGCALPMKPVVYTKTSKFLPWI 246
[Close]
BLAST of Serine protease hepsin vs. Ensembl Sea Lamprey
Match: ENSPMAT00000006641.1 (pep scaffold:Pmarinus_7.0:GL487373:2056:5756:-1 gene:ENSPMAG00000006000.1 transcript:ENSPMAT00000006641.1 gene_biotype:protein_coding transcript_biotype:protein_coding)

HSP 1 Score: 106.686 bits (265), Expect = 3.165e-26
Identity = 79/270 (29.26%), Postives = 120/270 (44.44%), Query Frame = 2 
Query:  296 IVSGVNSYYGEWPWIASLKNPVLKELIEKYAPTYMNWSLVGSDSHICGGTLINSEWIVTAQHCLYYNFSPQAIAITANWSATLGAYDISGYSQHSISIK-IDKVIFQENSFGMDLDDNDFAMMHLSTAVNFTDYIYPACLPT--NPLATPGNICYAVGWGTSYSLNETTNLDDGLSPGHA--LVNPILKHATLLIRERKESKACNTQTVKEICTSPLSGSVCRGDSGGPLLCQGENQSWIFVGITVRGSGCQKKTDRSIFTSVYHYLDFL 1090
            IV G  +  G WPW A L               Y N          CGG+L+++ W+V+A HC  +  S QA     +W+  LG +  S  +  ++  + + +VI  E  +     D D A+M LS  V+FTDY+ P CLP        PG  C+  GWGT   L++  +L + L       L + +L  A     + + S   +   V          SV +GDSGGP++CQ  N  W   GIT  G  C +     ++  V  +L+++
Sbjct:    1 IVGGTEARPGAWPWQAIL---------------YYN------GKFQCGGSLLSNRWVVSAAHC--FGASSQA----GSWTVYLGLHSRSNLNSSTVVARNVSRVIVHER-YNTTSHDYDVALMELSGGVSFTDYVQPVCLPAPFQRFPYPGKSCFVSGWGT---LSDGGDLPNVLQEAAVAILSHCVLPGAGAYSADPRLSVGDDMNAVS---------SVPQGDSGGPMVCQDSNSRWFLSGITSWGESCARANKPGVYGRVTKFLEWI 230
[Close]
BLAST of Serine protease hepsin vs. Ensembl Sea Lamprey
Match: ENSPMAT00000003648.1 (pep scaffold:Pmarinus_7.0:GL480237:8663:11960:-1 gene:ENSPMAG00000003338.1 transcript:ENSPMAT00000003648.1 gene_biotype:protein_coding transcript_biotype:protein_coding)

HSP 1 Score: 103.605 bits (257), Expect = 1.931e-25
Identity = 74/231 (32.03%), Postives = 108/231 (46.75%), Query Frame = 2 
Query:  434 CGGTLINSEWIVTAQHCLYYNFSPQAIAITAN----WSATLGAYDISGYSQHSISIK-IDKVIFQENSFGMDLDDNDFAMMHLSTAVNFTDYIYPACLPTN--PLATPGNICYAVGWGTSYSLNETTNLDDGLSP-GHALVNPILKHATLLIRERKESKACNTQTVKEICTSPLSGSVCRGDSGGPLLCQGENQSWIFVGITVRGSGCQKKTDRSIFTSVYHYLDFLVQTM 1102
            CGG+L++  W+V+A HCL        I + +N    W+  LG +  +  S  ++  + +++++  E   G    D D A+M LS  V+FTDYI P CLP        PG  C+  GWG    L E       LS  G     P   H  L +   + +   N+     IC       +C GDSGGPL+CQ  N  W   GIT  G GC +     +++ V  +LD++ Q M
Sbjct:    1 CGGSLLSDRWVVSAAHCL-------CIYLPSNNPNTWTVYLGLHSQNDLSASTVVARSVNRILIHERYNGSS-HDYDIALMQLSERVSFTDYIQPVCLPPRFQKFPYPGKSCFISGWG---KLFEGGKSYPYLSVYGVRTKQPQYCHV-LSLHTTRLTFYLNSGLQPLIC-------LCWGDSGGPLVCQNSNGRWYLSGITSWGYGCARAYQPGVYSRVTKFLDWIHQNM 212
[Close]
BLAST of Serine protease hepsin vs. Ensembl Sea Lamprey
Match: ENSPMAT00000009686.1 (pep scaffold:Pmarinus_7.0:GL480068:21029:23882:-1 gene:ENSPMAG00000008757.1 transcript:ENSPMAT00000009686.1 gene_biotype:protein_coding transcript_biotype:protein_coding)

HSP 1 Score: 101.679 bits (252), Expect = 1.263e-24
Identity = 65/227 (28.63%), Postives = 106/227 (46.70%), Query Frame = 2 
Query:  434 CGGTLINSEWIVTAQHCLYYNFSPQAIAITANWSATLGAYDISGYSQHSISIK-IDKVIFQENSFGMDLDDNDFAMMHLSTAVNFTDYIYPACLPTN--PLATPGNICYAVGWGTSYSLNETTNLDDGLSPGHALVNPILKHATLLIRERKE-SKACNTQTVKEICTSPLSGSVCRGDSGGPLLCQGENQSWIFVGITVRGSGCQKKTDRSIFTSVYHYLDFLVQTM 1102
            CGG+L +  W+V+A H +   + P +      W+  LG +  +  S  ++  + +++++  E   G    D D A+M LS  V+F DYI P CLP        PG  C+  GWG  +    + N          +   +++   L I    + S+       + I  + +   +CRGDSGGPL+CQ  N  W   GIT  G GC +     +++ V  +LD++ Q M
Sbjct:    1 CGGSLFSDRWVVSAAHNVVAVYLPPSNN-PNTWTVYLGLHSQNDLSASTVVARSVNRILIHERYNGSS-HDYDIALMELSELVSFIDYIQPVCLPPRFQKFPYPGKSCFISGWGKLFEGGNSIN---------HVSRYMIQIMYLKIHWNNDGSRVAELSGARGIYVTGIK-LICRGDSGGPLVCQDSNGRWYLSGITSWGYGCARAYQPGVYSRVTKFLDWIHQNM 215
[Close]
BLAST of Serine protease hepsin vs. Ensembl Sea Lamprey
Match: ENSPMAT00000009540.1 (pep scaffold:Pmarinus_7.0:GL479757:24061:27159:1 gene:ENSPMAG00000008628.1 transcript:ENSPMAT00000009540.1 gene_biotype:protein_coding transcript_biotype:protein_coding)

HSP 1 Score: 98.9821 bits (245), Expect = 7.657e-24
Identity = 78/266 (29.32%), Postives = 113/266 (42.48%), Query Frame = 2 
Query:  326 EWPWIASLKNPVLKELIEKYAPTYMNWSLVGSDSHICGGTLINSEWIVTAQHCLYYNFSPQAIAITANWSATLGAYDISGYSQHSISIK-IDKVIFQENSFGMDLDDNDFAMMHLSTAVNFTDYIYPACLPT--NPLATPGNICYAVGWGTSYSLNETTNLDDGLSPGHALVNPILKHATLLIRERKESKACNTQTVKEICTSPLSGSVC--RGDSGGPLLCQGENQSWIFVGITVRGSGCQKKTDRSIFTSVYHYLDFLVQTMNH 1108
            EWPW  SL N  L  L                    CGG+L++  W+V+A H    N +P        W+  LG +  +  S  ++  + +++++  E   G    D D A+M LS  V+F DYI P CLP        PG  C+  GWG    L E  N  D L         +     L  +++  + + N             G VC  +GDSGGPL+CQ  N  W   GIT  G GC +     +++ V  +LD++ Q M  
Sbjct:    1 EWPWQESLHN--LNRLT-------------------CGGSLLSDRWVVSAAHST--NNNPNT------WTVYLGLHSQNNLSASTVVARSVNRILIHERYNGSS-HDYDIALMELSELVSFIDYIQPVCLPPRFQKFPYPGKSCFISGWG---KLFEGGNSRDYL---------VSISQCLWCKKKATTSSSNI------------GVVCLLQGDSGGPLVCQDSNGRWYLSGITSWGYGCARAYQPGVYSRVTKFLDWIHQNMQQ 212
[Close]
BLAST of Serine protease hepsin vs. Ensembl Nematostella
Match: EDO38278 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7SDB3])

HSP 1 Score: 114.005 bits (284), Expect = 2.180e-28
Identity = 81/275 (29.45%), Postives = 133/275 (48.36%), Query Frame = 2 
Query:  296 IVSGVNSYYGEWPWIASLKNPVLKELIEKYAPTYMNWSLVGSDSHICGGTLINSEWIVTAQHCLYYNFSPQAIAITANWSATLGAYDISGYSQHSISIKIDKVIFQENSFGMDLDDNDFAMMHLSTAVNFTDYIYPACLPTNPLATPGNICYAVGWG-TSYSLNETTNLDDGLSPGHALVNPILKHATLLIRERKESKACNTQTVKEICTSPLSGSVCRGDSGGPLLCQGENQSWIFVGITVRGSGCQKKTDRSIFTSVYHYLDFLVQTMNHSPK 1117
            I+ G N+ +GEWPW  S+K               +N S   S  HICGG +I+  W++TA HC+    +       +N   T+G + +         I ++++I   N +  +  D D+A++ L+  +NFT Y+ P CLP +     G +CY  GWG T+Y  + + N    +  G  LVN    HAT L   RK      T  ++   T  ++ +VC GDSGGPL+C+     W  +G++  G  C +   + +F+ V   +D++ +   +  K
Sbjct:    4 IMGGANAEHGEWPWQVSMK---------------LNSS---SLPHICGGNVISPWWVLTAAHCVQDERA-------SNIKLTMGEWRLFNVDGTEQVIPVERIISHAN-YSYNTVDYDYALLKLTRPLNFTQYVQPVCLPDSDFPA-GTLCYVTGWGSTNYRGSPSPNYLQEV--GLPLVNHSQCHATYLTASRKI-----TPRMRCAGTEGVAKAVCSGDSGGPLVCE-RGGRWFLMGLSSWGWVCPQARPK-VFSDVLAAMDWIREKTRYYGK 242
[Close]
BLAST of Serine protease hepsin vs. Ensembl Nematostella
Match: EDO30506 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7T0K9])

HSP 1 Score: 110.153 bits (274), Expect = 4.501e-27
Identity = 81/277 (29.24%), Postives = 127/277 (45.85%), Query Frame = 2 
Query:  287 YRRIVSGVNSYYGEWPWIASLKNPVLKELIEKYAPTYMNWSLVGSDSHICGGTLINSEWIVTAQHCLYYNFSPQAIAITANWSATLGAYDISGYSQHSISIKIDKVIFQENSFGMDLDDNDFAMMHLSTAVNFTDYIYPACLPTNPLATP-GNICYAVGWGTSYSLNETTNLDDGLSPGHALVNPILKHATLLIRERKESK---ACNTQTVKEICTS---PLSGSVCRGDSGGPLLCQGENQSWIFVGITVRGSGCQKKTDRSIFTSVYHYLDFLVQ 1096
            + RIV G ++    WPW  SL+    +EL                  H CGGTLI  EW+VTA HC+  N SP      ++++  LGA+     +     IK+ K IF+ + F M    +D A++ L       D +  ACLP+     P G+ C+  GWG    ++ +  L D           IL+ A + I   ++ K        +   +C     P +   C+GDSGGPL+C+  N  W   G+   G+G  + T  +++T V +YLD++ +
Sbjct:    2 WTRIVGGHDAAPHSWPWQVSLR----EEL-----------------GHTCGGTLIAPEWVVTATHCIIMNPSP------SSYTVALGAHRRLSSNTAEQVIKV-KRIFKHSGFSMWRYRDDIALLQLERPAQLNDRVNVACLPSPGDVPPVGSKCWLTGWGR--QVDSSGPLPD-----------ILQQARIPIASHEDCKRKYGSGIYSYTHLCAGEAKPNAAGACQGDSGGPLVCE-RNGQWTLYGVVSFGAGNCEVTSYTVYTKVSNYLDWITK 236
[Close]
BLAST of Serine protease hepsin vs. Ensembl Nematostella
Match: EDO41061 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7S5B4])

HSP 1 Score: 108.227 bits (269), Expect = 3.149e-26
Identity = 82/287 (28.57%), Postives = 126/287 (43.90%), Query Frame = 2 
Query:  293 RIVSGVNSYYGEWPWIASLKNPVLKELIEKYAPTYMNWSLVGSDSHICGGTLINSEWIVTAQHCLYYNFSPQAIAITANWSATLGAYDISGYSQHSISIKIDKV-----IFQENSFGMDLDDNDFAMMHLSTAVNFTDYIYPACLP-TNPLATPGNICYAVGWGTSYSLNETTNLDDGLSPGHALVNPILKHATLLIRERKESKACNT--QTVKEICT-----SPLSGSVCRGDSGGPLLCQGENQSWIFVGITVRGSGCQKKTDRSIFTSVYHYLDFLVQTMNHSP 1114
            RI+ G  +   +WPW A +   V K                 S +H CGGTLI++EW+VTA HC++ N  P      +N+   LGA+D    S+ +++I +  +        + S+G D+     A+M L+        I PACLP      T G +CY  GWG +   N    L              L+ A + +   +E +  N   + V  +C      S +SG  C GDSGGP +C G +  W+  G    G    K +  S+FT +  ++D++   M   P
Sbjct:    3 RIIGGTTAAPHDWPWQAQILIHVDK-----------------SWNHRCGGTLIDTEWVVTAAHCVFQNIEP------SNYKIKLGAHDRES-SEGALTIPVTAIHMHTRFMTDGSYGYDI-----AIMKLANPAPIGHTISPACLPGLYDQVTSGTMCYVTGWGMTEYGNAGARL--------------LQQARIPVVSSEECERVNNKHRKVTMLCAGNGGNSSISG--CHGDSGGPFVCMGGDGRWVLRGAVSWGDNECKGSTYSVFTRISSFVDWIKCKMTSEP 244
[Close]
BLAST of Serine protease hepsin vs. Ensembl Nematostella
Match: EDO34066 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7SQF1])

HSP 1 Score: 107.457 bits (267), Expect = 5.614e-26
Identity = 80/284 (28.17%), Postives = 122/284 (42.96%), Query Frame = 2 
Query:  284 RYRRIVSGVNSYYGEWPWIASLKNPVLKELIEKYAPTYMNWSLVGSDSHICGGTLINSEWIVTAQHCLYYNFSPQAIAITANWSATLGAYDISGYSQHSISIKIDK----VIFQENSFGMDLDDNDFAMMHLSTAVNFTDYIYPACLPTNPLATP-GNICYAVGWGTSYSLNETTNLDDGLSPGHALVNPILKHATLLIRERKESKACNTQT----VKEICTSPLSGSV--CRGDSGGPLLCQGENQSWIFVGITVRGSGCQKKTDRSIFTSVYHYLDFLVQTM 1102
            R  RI+ G  +    WPW+ ++ N                        H CGG++I+  W+VTA HC+   +SP+AI       A   +  + GY Q++I  +I      VI   +  G      D A++HL+  + F+D I P CLP +    P G +CY  GWG        T LD G+       +P LK   + +  +    + N+ +     + +C     G    C GDSGGPL CQ E+  W+  G+   G  C       ++T V   L F+  T+
Sbjct:   12 REERIIGGQEAAKNTWPWMVTVNN----------------------TGHWCGGSIIDPHWVVTAGHCVV-PWSPRAIGTRVLRFAEHDSSRMEGYEQYAIPDRIHLHPGFVIGGVSHPGY----YDIALLHLAKPIQFSDRIQPICLPQDDTEFPAGKMCYLTGWGE-------TVLDSGV------FSPTLKQLKVPLVNKSVCNSNNSYSGIIHEQFMCAGYNQGGQDGCLGDSGGPLSCQTESGDWVLTGLMSWGEKCALPDKYGVYTDVRRMLPFIESTL 255
[Close]
BLAST of Serine protease hepsin vs. Ensembl Nematostella
Match: EDO47664 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7RLC0])

HSP 1 Score: 105.531 bits (262), Expect = 2.244e-25
Identity = 81/286 (28.32%), Postives = 129/286 (45.10%), Query Frame = 2 
Query:  275 IINRYRRIVSGVNSYYGEWPWIASLKNPVLKELIEKYAPTYMNWSLVGSDSHICGGTLINSEWIVTAQHCLYYNFSPQAIAITAN--WSATLGAYDISGYSQHSISIKIDKVIFQENSFGMDLDDNDFAMMHLSTAV-NFTDYIYPACLPTNPLATP----GNICYAVGWGTSYSLNETTNLDDGLSPGHALVNPILKHATLLIRERKESKA---CNTQTVKEICTSPLSGSV--CRGDSGGPLLCQGENQSWIFV--GITVRGSGCQKKTDRSIFTSVYHYLDFL 1090
            + N   RIV G  +   +WPW A LK  +                    D+ +CGG+LIN EW+VTA HC+  N   +   +  +      LG  D++ +  + I   + ++    +   + L  ND A++ L T +  FT ++ P CLPT+  ATP    G  C   G+G    + E  +L           +  L+HAT+ +    E +A    +T   K IC     G +  C+GDSGGP +C+    +  F+  G    G GC +K    I+T +  YL+++
Sbjct:    3 VRNALGRIVGGQTAKVEDWPWQAGLKKGL-------------------DDTIVCGGSLINREWVVTAAHCIDRNNPSRTGCVVPDPPIRVILGESDVTKHEGNEIHRDVAQICIHPDYHEIKL-TNDLALIRLRTPITTFTKHVRPVCLPTS--ATPDLAVGTNCTVTGYG---RVGENEDL-----------STQLRHATIPVLSVSECRANYSGHTINDKVICAGYEGGKIDSCKGDSGGPFVCKDPRVTSRFILHGAVSWGVGCARKGQPGIYTDIKKYLNWI 252
[Close]
BLAST of Serine protease hepsin vs. Ensembl Medaka
Match: tmprss15 (Oryzias latipes enteropeptidase-1 (ep-1), mRNA. [Source:RefSeq mRNA;Acc:NM_001104898])

HSP 1 Score: 131.339 bits (329), Expect = 7.158e-31
Identity = 93/309 (30.10%), Postives = 141/309 (45.63%), Query Frame = 2 
Query:  209 NLTQIPCG-KQMIEKSPQSNNTKIINRYRRIVSGVNSYYGEWPWIASLKNPVLKELIEKYAPTYMNWSLVGSDSHICGGTLINSEWIVTAQHCLYYNFSPQAIAITANWSATLGAYDISGYSQHSISIK-IDKVIFQENSFGMDLDDNDFAMMHLSTAVNFTDYIYPACLPTNPLATP-GNICYAVGWGTSYSLNETTNLDDGLSPGHALVNPILKHATLLIRERKESKAC---NTQTVKEICTSPLSGSV--CRGDSGGPLLCQGENQSWIFVGITVRGSGCQKKTDRSIFTSVYHYLDFLVQTMNHS 1111
            N +  PCG +Q+     QS N+K  N   R+V GVN+  G WPW+ SL                 +W       H CG +LI  +W++TA HC+Y   +         WSA LG +  S  +   + I+ +D++I  +N +     + D AMMHL   VNFT+++ P CL +     P G  C+  GWG      E  +L D           IL+ A + + ++ E +      T T   +C     G V  C+GDSGGPL+C  E+  W  +G+T  G GC +      +  V  +  ++ +T   S
Sbjct:  772 NCSNQPCGQRQVYNHGDQSENSKENNGVPRVVGGVNAEKGAWPWMVSL-----------------HWR----GRHGCGASLIGRDWLLTAAHCVYGKNTHLQY-----WSAVLGLHAQSSMNSQEVQIRQVDRIIINKN-YNRRTKEADIAMMHLQQPVNFTEWVLPVCLASEGQHFPAGRRCFIAGWGRDA---EGGSLPD-----------ILQEAEVPLVDQDECQRLLPEYTFTSSMLCAGYPEGGVDSCQGDSGGPLMCL-EDARWTLIGVTSFGVGCGRPERPGAYARVSAFASWIAETRRSS 1038
[Close]
BLAST of Serine protease hepsin vs. Ensembl Medaka
Match: tmprss5 (transmembrane serine protease 5 [Source:NCBI gene;Acc:101167385])

HSP 1 Score: 120.553 bits (301), Expect = 3.652e-30
Identity = 87/287 (30.31%), Postives = 129/287 (44.95%), Query Frame = 2 
Query:  275 IINRYRRIVSGVNSYYGEWPWIASLKNPVLKELIEKYAPTYMNWSLVGSDSHICGGTLINSEWIVTAQHCLYYNFSPQAIAITANWSATLGAYDISGYSQHSISI---KIDKVIFQENSFGMDLDDNDFAMMHLSTAVNFTDYIYPACLPTNPLATPGNI-CYAVGWGTSYSLNETTNLDDGLSPGHALVNPILKHATL-LIRERKESKAC---NTQTVKEICTSPLSGSV--CRGDSGGPLLCQGENQSWIFVGITVRGSGCQKKTDRSIFTSVYHYLDFLVQTMN 1105
            I  +  RI+ G  +  G WPW  SL                       S  H CGG++I  +WIVTA HC Y +                   +I G++Q   ++   K++K+I+ +N +     D+D A++ L T +NFTD I P CLP      PG   C+  GWG        T  DD  SP        LK A + LI  +K + +C      T + +C     G V  C+GDSGGPL+CQ E+  W  VG+   G+GC +     ++T V  +L ++ + + 
Sbjct:   16 ITTKLPRIIGGAEAALGRWPWQVSLYY---------------------SSRHTCGGSIITRQWIVTAAHCHYRS-------------------EIQGFNQSLTAVQRWKLEKIIYNKN-YNHRTHDSDIALIKLRTPLNFTDTIRPICLPQYKYDLPGGTQCWISGWG-------YTKPDDVQSPD------TLKEAPVPLISTKKCNSSCMYNGEITPRMLCAGYTEGKVDACQGDSGGPLVCQ-EDTVWRLVGVVSWGTGCAEPNHPGVYTKVAEFLSWIYEMIE 247
[Close]
BLAST of Serine protease hepsin vs. Ensembl Medaka
Match: tmprss5 (transmembrane serine protease 5 [Source:NCBI gene;Acc:101167385])

HSP 1 Score: 120.168 bits (300), Expect = 8.343e-29
Identity = 88/281 (31.32%), Postives = 129/281 (45.91%), Query Frame = 2 
Query:  293 RIVSGVNSYYGEWPWIASLKNPVLKELIEKYAPTYMNWSLVGSDSHICGGTLINSEWIVTAQHCLYYNFSPQAIAITANWSATLGAYDISGYS--QHSISIKIDKVIFQENSFGMDLDDNDFAMMHLSTAVNFTDYIYPACLPTNPLATPGNI-CYAVGWGTSYSLNETTNLDDGLSPGHALVNPILKHATL-LIRERKESKAC---NTQTVKEICTSPLSGSV--CRGDSGGPLLCQGENQSWIFVGITVRGSGCQKKTDRSIFTSVYHYLDFLVQTMNH 1108
            RI+ G  +  G WPW  SL                       S  H CGG++I  +WIVTA HC++    PQ     ++W    G    S     QH+    ++K+I+ +N +     D+D A++ L T +NFTD I P CLP      PG   C+  GWG        T  DD  SP        LK A + LI  +K + +C      T + +C     G V  C+GDSGGPL+CQ E+  W  VG+   G+GC +     ++T V  +L ++ + + +
Sbjct:  142 RIIGGAEAALGRWPWQVSLYY---------------------SSRHTCGGSIITRQWIVTAAHCVHNYRLPQV----SSWVVYAGIVTRSSAKMVQHT-GHAVEKIIYNKN-YNHRTHDSDIALIKLRTPLNFTDTIRPICLPQYKYDLPGGTQCWISGWG-------YTKPDDVQSPD------TLKEAPVPLISTKKCNSSCMYNGEITPRMLCAGYTEGKVDACQGDSGGPLVCQ-EDTVWRLVGVVSWGTGCAEPNHPGVYTKVAEFLSWIYEMIEN 381
[Close]
BLAST of Serine protease hepsin vs. Ensembl Medaka
Match: ENSORLT00000010945.2 (pep primary_assembly:ASM223467v1:20:17371788:17374100:1 gene:ENSORLG00000008718.2 transcript:ENSORLT00000010945.2 gene_biotype:protein_coding transcript_biotype:protein_coding)

HSP 1 Score: 114.39 bits (285), Expect = 1.163e-27
Identity = 76/274 (27.74%), Postives = 122/274 (44.53%), Query Frame = 2 
Query:  293 RIVSGVNSYYGEWPWIASLKNPVLKELIEKYAPTYMNWSLVGSDSHICGGTLINSEWIVTAQHCLYYNFSPQAIAITANWSATLGAYDISGYSQHSISIKIDKVIFQENSFGMDLDDNDFAMMHLSTAVNFTDYIYPACLPTNPLA-TPGNICYAVGWGTSYSLNETTNLDDGLSPGHALVNPILKHATLLIRERKESKACN-----TQTVKEICTSPLSGSV--CRGDSGGPLLCQGENQSWIFVGITVRGSGCQKKTDRSIFTSVYHYLDFL 1090
            +IV G ++  G WPW  SL+       +E+Y              H+CG TL+++ W+++A HC  +  S    +    W A +G   +     H  + ++ + I     +     D D A++ LS  V F+D + P C+P +    T G  CY  GWG          ++D L+         L+ A++ I  RK    CN       T + +C   L G V  C+GDSGGPL+C    + W   GI   G GC ++    ++T V  + D++
Sbjct:   53 KIVGGSDALAGSWPWQVSLQ-------MERYG-------------HVCGATLVSNRWLISAAHC--FQDSDAIYSDPHAWRAYMGMR-VMARGNHGAATRLIRRILLHPQYDQFTSDYDIALLELSAPVFFSDLVQPVCVPASSHTFTTGTSCYVTGWGVL--------MEDELAS-------RLQEASVKIINRK---TCNKLYDDAVTPRMMCAGNLQGGVDACQGDSGGPLVCLERGKRWFLAGIVSWGEGCARQNRPGVYTQVVKFTDWI 285
[Close]
BLAST of Serine protease hepsin vs. Ensembl Medaka
Match: ENSORLT00000028845.1 (transmembrane protease serine 9-like [Source:NCBI gene;Acc:101157216])

HSP 1 Score: 115.546 bits (288), Expect = 8.357e-27
Identity = 88/277 (31.77%), Postives = 127/277 (45.85%), Query Frame = 2 
Query:  281 NRYRRIVSGVNSYYGEWPWIASLKNPVLKELIEKYAPTYMNWSLVGSDSHICGGTLINSEWIVTAQHCLYYNFSPQAIAITANWSATLGAYDISGYSQHSISIKIDKVIFQENSFGMDLDDNDFAMMHLSTAVNFTDYIYPACL-PTNPLATPGNICYAVGWGTSYSLNETTNLDDGLSPGHALVNP-ILKHATLLI---RERKESKACNTQTVKEICTSPLSGS--VCRGDSGGPLLCQGENQSWIFVGITVRGSGCQKKTDRSIFTSVYHYLDFL 1090
            N   RIV G ++  G WPW  SL+                      + SH CGG+LIN++W++TA HC      P+  A   N    LG   + G + +S+S  +  VI   N +  +  DND A++ LS+ VNFT+YI P CL  TN     G   +  GWGT  S             G +L  P  L+   + I   R+ K S   ++ T   +C   L+G    C+GDSGGPL+ + +N  WI  G+   G GC       ++T V  Y  ++
Sbjct:   10 NLNNRIVGGQDAPAGFWPWQVSLQ----------------------TSSHFCGGSLINNQWVLTAAHCF-----PRGSASGVN--VVLGLQSLQGSNPNSVSQTVTTVIVHPN-YNSETSDNDIALLQLSSPVNFTNYITPVCLSATNSTFYSGVNTWVTGWGTIRS-------------GVSLPAPQTLQEVQVPIVGNRQCKCSYGASSITDNMVCAGLLAGGKDSCQGDSGGPLVIK-QNNRWIQAGVVSFGEGCALPNFPGVYTRVSQYQTWI 242

HSP 2 Score: 56.9954 bits (136), Expect = 4.644e-8
Identity = 36/147 (24.49%), Postives = 64/147 (43.54%), Query Frame = 2 
Query:  323 GEWPWIASLKNPVLKELIEKYAPTYMNWSLVGSDSHICGGTLINSEWIVTAQHCLYYNFSPQAIAITANWSATLGAYDISGYSQHSISIKIDKVIFQENSFGMDLDDNDFAMMHLSTAVNFTDYIYPACLPTNPLATPGNICYAVGW 763
            G+WPW+ASL+                      +  H+CGGTL++ + +++  +C    FS   +A  + W+  LG    +G +   +S+ +  +     +       ++ A++ LST     +YI P CL        G  C+A GW
Sbjct:  303 GQWPWMASLQK---------------------NGQHVCGGTLVSLDSVLSDANC----FSSPPVA--SEWTVVLGRLKQNGSNPFEVSLNVTNITLSNQT------GSNVAVLQLSTQPPLNNYIQPICLDNGRTFPLGTTCWAAGW 416
[Close]
BLAST of Serine protease hepsin vs. Planmine SMEST
Match: SMESG000019950.1 (SMESG000019950.1)

HSP 1 Score: 701.049 bits (1808), Expect = 0.000e+0
Identity = 336/336 (100.00%), Postives = 336/336 (100.00%), Query Frame = 2 
Query:  140 MNLNPILMIFISCSIKLFSGTKYNLTQIPCGKQMIEKSPQSNNTKIINRYRRIVSGVNSYYGEWPWIASLKNPVLKELIEKYAPTYMNWSLVGSDSHICGGTLINSEWIVTAQHCLYYNFSPQAIAITANWSATLGAYDISGYSQHSISIKIDKVIFQENSFGMDLDDNDFAMMHLSTAVNFTDYIYPACLPTNPLATPGNICYAVGWGTSYSLNETTNLDDGLSPGHALVNPILKHATLLIRERKESKACNTQTVKEICTSPLSGSVCRGDSGGPLLCQGENQSWIFVGITVRGSGCQKKTDRSIFTSVYHYLDFLVQTMNHSPKNVKIPIYHLQ 1147
            MNLNPILMIFISCSIKLFSGTKYNLTQIPCGKQMIEKSPQSNNTKIINRYRRIVSGVNSYYGEWPWIASLKNPVLKELIEKYAPTYMNWSLVGSDSHICGGTLINSEWIVTAQHCLYYNFSPQAIAITANWSATLGAYDISGYSQHSISIKIDKVIFQENSFGMDLDDNDFAMMHLSTAVNFTDYIYPACLPTNPLATPGNICYAVGWGTSYSLNETTNLDDGLSPGHALVNPILKHATLLIRERKESKACNTQTVKEICTSPLSGSVCRGDSGGPLLCQGENQSWIFVGITVRGSGCQKKTDRSIFTSVYHYLDFLVQTMNHSPKNVKIPIYHLQ
Sbjct:    1 MNLNPILMIFISCSIKLFSGTKYNLTQIPCGKQMIEKSPQSNNTKIINRYRRIVSGVNSYYGEWPWIASLKNPVLKELIEKYAPTYMNWSLVGSDSHICGGTLINSEWIVTAQHCLYYNFSPQAIAITANWSATLGAYDISGYSQHSISIKIDKVIFQENSFGMDLDDNDFAMMHLSTAVNFTDYIYPACLPTNPLATPGNICYAVGWGTSYSLNETTNLDDGLSPGHALVNPILKHATLLIRERKESKACNTQTVKEICTSPLSGSVCRGDSGGPLLCQGENQSWIFVGITVRGSGCQKKTDRSIFTSVYHYLDFLVQTMNHSPKNVKIPIYHLQ 336
[Close]
BLAST of Serine protease hepsin vs. Planmine SMEST
Match: SMESG000019950.1 (SMESG000019950.1)

HSP 1 Score: 686.797 bits (1771), Expect = 0.000e+0
Identity = 329/329 (100.00%), Postives = 329/329 (100.00%), Query Frame = 2 
Query:  161 MIFISCSIKLFSGTKYNLTQIPCGKQMIEKSPQSNNTKIINRYRRIVSGVNSYYGEWPWIASLKNPVLKELIEKYAPTYMNWSLVGSDSHICGGTLINSEWIVTAQHCLYYNFSPQAIAITANWSATLGAYDISGYSQHSISIKIDKVIFQENSFGMDLDDNDFAMMHLSTAVNFTDYIYPACLPTNPLATPGNICYAVGWGTSYSLNETTNLDDGLSPGHALVNPILKHATLLIRERKESKACNTQTVKEICTSPLSGSVCRGDSGGPLLCQGENQSWIFVGITVRGSGCQKKTDRSIFTSVYHYLDFLVQTMNHSPKNVKIPIYHLQ 1147
            MIFISCSIKLFSGTKYNLTQIPCGKQMIEKSPQSNNTKIINRYRRIVSGVNSYYGEWPWIASLKNPVLKELIEKYAPTYMNWSLVGSDSHICGGTLINSEWIVTAQHCLYYNFSPQAIAITANWSATLGAYDISGYSQHSISIKIDKVIFQENSFGMDLDDNDFAMMHLSTAVNFTDYIYPACLPTNPLATPGNICYAVGWGTSYSLNETTNLDDGLSPGHALVNPILKHATLLIRERKESKACNTQTVKEICTSPLSGSVCRGDSGGPLLCQGENQSWIFVGITVRGSGCQKKTDRSIFTSVYHYLDFLVQTMNHSPKNVKIPIYHLQ
Sbjct:    1 MIFISCSIKLFSGTKYNLTQIPCGKQMIEKSPQSNNTKIINRYRRIVSGVNSYYGEWPWIASLKNPVLKELIEKYAPTYMNWSLVGSDSHICGGTLINSEWIVTAQHCLYYNFSPQAIAITANWSATLGAYDISGYSQHSISIKIDKVIFQENSFGMDLDDNDFAMMHLSTAVNFTDYIYPACLPTNPLATPGNICYAVGWGTSYSLNETTNLDDGLSPGHALVNPILKHATLLIRERKESKACNTQTVKEICTSPLSGSVCRGDSGGPLLCQGENQSWIFVGITVRGSGCQKKTDRSIFTSVYHYLDFLVQTMNHSPKNVKIPIYHLQ 329
[Close]
BLAST of Serine protease hepsin vs. Planmine SMEST
Match: SMESG000019950.1 (SMESG000019950.1)

HSP 1 Score: 667.152 bits (1720), Expect = 0.000e+0
Identity = 324/336 (96.43%), Postives = 324/336 (96.43%), Query Frame = 2 
Query:  140 MNLNPILMIFISCSIKLFSGTKYNLTQIPCGKQMIEKSPQSNNTKIINRYRRIVSGVNSYYGEWPWIASLKNPVLKELIEKYAPTYMNWSLVGSDSHICGGTLINSEWIVTAQHCLYYNFSPQAIAITANWSATLGAYDISGYSQHSISIKIDKVIFQENSFGMDLDDNDFAMMHLSTAVNFTDYIYPACLPTNPLATPGNICYAVGWGTSYSLNETTNLDDGLSPGHALVNPILKHATLLIRERKESKACNTQTVKEICTSPLSGSVCRGDSGGPLLCQGENQSWIFVGITVRGSGCQKKTDRSIFTSVYHYLDFLVQTMNHSPKNVKIPIYHLQ 1147
            MNLNPILMIFISCSIKLFSGTKYNLTQIPCGKQMIEKSPQSNNTKIINRYRRIVSGVNSYYGEWPWIASLKNPVLKELIEKYAPTYMNWSLVGSDSHICGGTLINSEWIVTAQHCLYYNFSPQAIAITANWSATLGAYDISGYSQHSISIKIDKVIFQENSFGMDLDDNDFAMMHLSTAVNFTDYIYPACLPTNPLATPGNICYAVGWGTSYSLNET            LVNPILKHATLLIRERKESKACNTQTVKEICTSPLSGSVCRGDSGGPLLCQGENQSWIFVGITVRGSGCQKKTDRSIFTSVYHYLDFLVQTMNHSPKNVKIPIYHLQ
Sbjct:    1 MNLNPILMIFISCSIKLFSGTKYNLTQIPCGKQMIEKSPQSNNTKIINRYRRIVSGVNSYYGEWPWIASLKNPVLKELIEKYAPTYMNWSLVGSDSHICGGTLINSEWIVTAQHCLYYNFSPQAIAITANWSATLGAYDISGYSQHSISIKIDKVIFQENSFGMDLDDNDFAMMHLSTAVNFTDYIYPACLPTNPLATPGNICYAVGWGTSYSLNET------------LVNPILKHATLLIRERKESKACNTQTVKEICTSPLSGSVCRGDSGGPLLCQGENQSWIFVGITVRGSGCQKKTDRSIFTSVYHYLDFLVQTMNHSPKNVKIPIYHLQ 324
[Close]
BLAST of Serine protease hepsin vs. Planmine SMEST
Match: SMESG000019950.1 (SMESG000019950.1)

HSP 1 Score: 652.514 bits (1682), Expect = 0.000e+0
Identity = 317/329 (96.35%), Postives = 317/329 (96.35%), Query Frame = 2 
Query:  161 MIFISCSIKLFSGTKYNLTQIPCGKQMIEKSPQSNNTKIINRYRRIVSGVNSYYGEWPWIASLKNPVLKELIEKYAPTYMNWSLVGSDSHICGGTLINSEWIVTAQHCLYYNFSPQAIAITANWSATLGAYDISGYSQHSISIKIDKVIFQENSFGMDLDDNDFAMMHLSTAVNFTDYIYPACLPTNPLATPGNICYAVGWGTSYSLNETTNLDDGLSPGHALVNPILKHATLLIRERKESKACNTQTVKEICTSPLSGSVCRGDSGGPLLCQGENQSWIFVGITVRGSGCQKKTDRSIFTSVYHYLDFLVQTMNHSPKNVKIPIYHLQ 1147
            MIFISCSIKLFSGTKYNLTQIPCGKQMIEKSPQSNNTKIINRYRRIVSGVNSYYGEWPWIASLKNPVLKELIEKYAPTYMNWSLVGSDSHICGGTLINSEWIVTAQHCLYYNFSPQAIAITANWSATLGAYDISGYSQHSISIKIDKVIFQENSFGMDLDDNDFAMMHLSTAVNFTDYIYPACLPTNPLATPGNICYAVGWGTSYSLNET            LVNPILKHATLLIRERKESKACNTQTVKEICTSPLSGSVCRGDSGGPLLCQGENQSWIFVGITVRGSGCQKKTDRSIFTSVYHYLDFLVQTMNHSPKNVKIPIYHLQ
Sbjct:    1 MIFISCSIKLFSGTKYNLTQIPCGKQMIEKSPQSNNTKIINRYRRIVSGVNSYYGEWPWIASLKNPVLKELIEKYAPTYMNWSLVGSDSHICGGTLINSEWIVTAQHCLYYNFSPQAIAITANWSATLGAYDISGYSQHSISIKIDKVIFQENSFGMDLDDNDFAMMHLSTAVNFTDYIYPACLPTNPLATPGNICYAVGWGTSYSLNET------------LVNPILKHATLLIRERKESKACNTQTVKEICTSPLSGSVCRGDSGGPLLCQGENQSWIFVGITVRGSGCQKKTDRSIFTSVYHYLDFLVQTMNHSPKNVKIPIYHLQ 317
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BLAST of Serine protease hepsin vs. Planmine SMEST
Match: SMESG000019955.1 (SMESG000019955.1)

HSP 1 Score: 561.222 bits (1445), Expect = 0.000e+0
Identity = 265/266 (99.62%), Postives = 266/266 (100.00%), Query Frame = 2 
Query: 1322 MVSIQYGGGPTIEQQRAFCNPPEGSHIPGYLGFIPQAKFEVGKTFARESHDVARKLPYYNGPRNASVKHFYPEVGKTKDCENRSIFQDEFPKNKLPIPTGDNKYTEKMMPGYSGDIPHWNYKFGGTYRSICDEAVNEFITDYERNEAKMNDIKKMASMFPKLRPICSDLRVKDHMNLWSDNLTKMSTLASDRRHILEPPIPGYTGFVPRKDNTEVGLGNRYHEAAKHCFESFVTENSRHFQKLEEPMKVKNNTYTVQDQKSLVVSV 2119
            MVSIQYGGGPTIEQQRAFCNPPEGSHIPGYLGFIPQAKFEVGKTFARESHDVARKLPYYNGPRNASVKHFYPEVGKTKDCENRSIFQDEFPKNKLPIPTGDNKYTEKMMPGYSGDIPHWNYKFGGTYRSICDEAVNEFITDYERNEAKMNDIKKMASMFPKLRPICSDLRVKDHMNLWSDNLTKMSTLASDRRHILEPPIPGYTGFVPRKDNTEVGLGNRYHEAAKHCFESFVTENSRHFQKLEEPMKVKNNTYTVQDQKSLVVS+
Sbjct:    1 MVSIQYGGGPTIEQQRAFCNPPEGSHIPGYLGFIPQAKFEVGKTFARESHDVARKLPYYNGPRNASVKHFYPEVGKTKDCENRSIFQDEFPKNKLPIPTGDNKYTEKMMPGYSGDIPHWNYKFGGTYRSICDEAVNEFITDYERNEAKMNDIKKMASMFPKLRPICSDLRVKDHMNLWSDNLTKMSTLASDRRHILEPPIPGYTGFVPRKDNTEVGLGNRYHEAAKHCFESFVTENSRHFQKLEEPMKVKNNTYTVQDQKSLVVSM 266
The following BLAST results are available for this feature:
BLAST of Serine protease hepsin vs. Ensembl Human
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Human e!99)
Total hits: 5
Match NameE-valueIdentityDescription
TMPRSS151.769e-2732.14transmembrane serine protease 15 [Source:HGNC Symb... [more]
TMPRSS33.713e-2730.88transmembrane serine protease 3 [Source:HGNC Symbo... [more]
TMPRSS34.487e-2730.88transmembrane serine protease 3 [Source:HGNC Symbo... [more]
TMPRSS34.487e-2730.88transmembrane serine protease 3 [Source:HGNC Symbo... [more]
TMPRSS34.712e-2729.82transmembrane serine protease 3 [Source:HGNC Symbo... [more]
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BLAST of Serine protease hepsin vs. Ensembl Celegans
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99)
Total hits: 5
Match NameE-valueIdentityDescription
svh-12.944e-1923.67HGF/MSP/plasminogen-like protein [Source:UniProtK... [more]
try-17.897e-1325.00TRYpsin-like protease [Source:UniProtKB/TrEMBL;Ac... [more]
try-38.256e-724.77TRYpsin-like protease [Source:UniProtKB/TrEMBL;Ac... [more]
try-38.917e-724.77TRYpsin-like protease [Source:UniProtKB/TrEMBL;Ac... [more]
T21E12.39.327e-721.81pep chromosome:WBcel235:I:4401956:4404585:1 gene:W... [more]
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BLAST of Serine protease hepsin vs. Ensembl Fly
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99)
Total hits: 5
Match NameE-valueIdentityDescription
CG106631.421e-2126.59gene:FBgn0036287 transcript:FBtr0346570[more]
CG106631.421e-2126.59gene:FBgn0036287 transcript:FBtr0113167[more]
Corin2.788e-2025.26gene:FBgn0033192 transcript:FBtr0088909[more]
Corin2.788e-2025.26gene:FBgn0033192 transcript:FBtr0336996[more]
CG93723.243e-1926.21gene:FBgn0036891 transcript:FBtr0074945[more]
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BLAST of Serine protease hepsin vs. Ensembl Zebrafish
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99)
Total hits: 5
Match NameE-valueIdentityDescription
tmprss52.125e-2930.91transmembrane serine protease 5 [Source:ZFIN;Acc:Z... [more]
tmprss53.203e-2930.91transmembrane serine protease 5 [Source:ZFIN;Acc:Z... [more]
tmprss157.323e-2930.07transmembrane serine protease 15 [Source:ZFIN;Acc:... [more]
tmprss155.374e-2829.93transmembrane serine protease 15 [Source:ZFIN;Acc:... [more]
ela2l1.120e-2732.13elastase 2 like [Source:ZFIN;Acc:ZDB-GENE-040511-1... [more]
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BLAST of Serine protease hepsin vs. Ensembl Xenopus
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99)
Total hits: 5
Match NameE-valueIdentityDescription
ENSXETT00000031482.17.570e-3329.24pep primary_assembly:Xenopus_tropicalis_v9.1:9:246... [more]
ENSXETT00000021860.17.418e-3229.15pep primary_assembly:Xenopus_tropicalis_v9.1:KV461... [more]
ENSXETT00000035256.19.186e-3229.93pep primary_assembly:Xenopus_tropicalis_v9.1:KV461... [more]
ENSXETT00000030834.18.042e-3132.12serine protease 27-like [Source:NCBI gene;Acc:1004... [more]
fus1.813e-3028.72FUS RNA binding protein [Source:Xenbase;Acc:XB-GEN... [more]
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BLAST of Serine protease hepsin vs. Ensembl Mouse
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99)
Total hits: 5
Match NameE-valueIdentityDescription
Tmprss151.082e-2730.04transmembrane protease, serine 15 [Source:MGI Symb... [more]
Tmprss151.135e-2730.04transmembrane protease, serine 15 [Source:MGI Symb... [more]
Klkb12.968e-2729.08kallikrein B, plasma 1 [Source:MGI Symbol;Acc:MGI:... [more]
Prss301.543e-2627.66protease, serine 30 [Source:MGI Symbol;Acc:MGI:135... [more]
Prss301.543e-2627.66protease, serine 30 [Source:MGI Symbol;Acc:MGI:135... [more]
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BLAST of Serine protease hepsin vs. UniProt/SwissProt
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt)
Total hits: 5
Match NameE-valueIdentityDescription
sp|P98072|ENTK_BOVIN7.381e-2829.37Enteropeptidase OS=Bos taurus OX=9913 GN=TMPRSS15 ... [more]
sp|Q90WD8|OVCH2_BUFJA4.700e-2727.61Ovochymase-2 OS=Bufo japonicus OX=8387 GN=OVCH2 PE... [more]
sp|P97435|ENTK_MOUSE7.939e-2730.04Enteropeptidase OS=Mus musculus OX=10090 GN=Tmprss... [more]
sp|P98073|ENTK_HUMAN8.495e-2732.14Enteropeptidase OS=Homo sapiens OX=9606 GN=TMPRSS1... [more]
sp|P14272|KLKB1_RAT1.221e-2630.07Plasma kallikrein OS=Rattus norvegicus OX=10116 GN... [more]
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BLAST of Serine protease hepsin vs. TrEMBL
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL)
Total hits: 5
Match NameE-valueIdentityDescription
A0A075A3B09.421e-10951.37Uncharacterized protein OS=Opisthorchis viverrini ... [more]
A0A4S2M5Y27.457e-10750.76Uncharacterized protein OS=Opisthorchis felineus O... [more]
A0A504YZT81.670e-9946.50Uncharacterized protein OS=Fasciola gigantica OX=4... [more]
H2KV502.150e-9549.33Protein FAM166B (Fragment) OS=Clonorchis sinensis ... [more]
A0A4E0R8U72.345e-9443.44Uncharacterized protein OS=Fasciola hepatica OX=61... [more]
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BLAST of Serine protease hepsin vs. Ensembl Cavefish
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99)
Total hits: 5
Match NameE-valueIdentityDescription
tmprss58.565e-3132.51transmembrane serine protease 5 [Source:ZFIN;Acc:Z... [more]
ENSAMXT00000033802.13.596e-2827.86pep primary_assembly:Astyanax_mexicanus-2.0:3:2189... [more]
ENSAMXT00000048530.15.723e-2827.43pep primary_assembly:Astyanax_mexicanus-2.0:13:202... [more]
tmprss57.530e-2832.04transmembrane serine protease 5 [Source:ZFIN;Acc:Z... [more]
si:dkey-32n7.91.039e-2730.98chymotrypsin-like protease CTRL-1 [Source:NCBI gen... [more]
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BLAST of Serine protease hepsin vs. Ensembl Sea Lamprey
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99)
Total hits: 5
Match NameE-valueIdentityDescription
ENSPMAT00000006128.13.079e-2829.67pep scaffold:Pmarinus_7.0:GL484169:9759:12797:-1 g... [more]
ENSPMAT00000006641.13.165e-2629.26pep scaffold:Pmarinus_7.0:GL487373:2056:5756:-1 ge... [more]
ENSPMAT00000003648.11.931e-2532.03pep scaffold:Pmarinus_7.0:GL480237:8663:11960:-1 g... [more]
ENSPMAT00000009686.11.263e-2428.63pep scaffold:Pmarinus_7.0:GL480068:21029:23882:-1 ... [more]
ENSPMAT00000009540.17.657e-2429.32pep scaffold:Pmarinus_7.0:GL479757:24061:27159:1 g... [more]
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BLAST of Serine protease hepsin vs. Ensembl Yeast
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46)
Total hits: 0
Match NameE-valueIdentityDescription
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BLAST of Serine protease hepsin vs. Ensembl Nematostella
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46)
Total hits: 5
Match NameE-valueIdentityDescription
EDO382782.180e-2829.45Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7... [more]
EDO305064.501e-2729.24Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7... [more]
EDO410613.149e-2628.57Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7... [more]
EDO340665.614e-2628.17Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7... [more]
EDO476642.244e-2528.32Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7... [more]
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BLAST of Serine protease hepsin vs. Ensembl Medaka
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99)
Total hits: 5
Match NameE-valueIdentityDescription
tmprss157.158e-3130.10Oryzias latipes enteropeptidase-1 (ep-1), mRNA. [S... [more]
tmprss53.652e-3030.31transmembrane serine protease 5 [Source:NCBI gene;... [more]
tmprss58.343e-2931.32transmembrane serine protease 5 [Source:NCBI gene;... [more]
ENSORLT00000010945.21.163e-2727.74pep primary_assembly:ASM223467v1:20:17371788:17374... [more]
ENSORLT00000028845.18.357e-2731.77transmembrane protease serine 9-like [Source:NCBI ... [more]
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BLAST of Serine protease hepsin vs. Planmine SMEST
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST)
Total hits: 5
Match NameE-valueIdentityDescription
SMESG000019950.10.000e+0100.00SMESG000019950.1[more]
SMESG000019950.10.000e+0100.00SMESG000019950.1[more]
SMESG000019950.10.000e+096.43SMESG000019950.1[more]
SMESG000019950.10.000e+096.35SMESG000019950.1[more]
SMESG000019955.10.000e+099.62SMESG000019955.1[more]
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Sequences
The following sequences are available for this feature:

transcript sequence

>SMED30013024 ID=SMED30013024|Name=Serine protease hepsin|organism=Schmidtea mediterranea sexual|type=transcript|length=2447bp
CGAAAAAAACAAAATAAATTTCAGTCGATATTAAATCTTTTCTGGTTGGT
TGGAATTTACGCGAATCAAAATACAAATAATTATGATACTTATTATCATA
TCATAAAATGGAAGAATATTTAAAAAATAGAAATCGGAAATGAATTTGAA
TCCTATATTAATGATTTTCATATCTTGTTCGATTAAACTTTTCTCCGGAA
CCAAATATAATCTGACTCAAATTCCTTGTGGAAAACAGATGATAGAAAAA
TCACCTCAGTCAAACAATACAAAAATTATAAATAGATACAGACGAATCGT
TAGTGGGGTAAATTCATATTATGGAGAGTGGCCTTGGATTGCCTCTTTAA
AGAATCCAGTTTTAAAAGAGTTAATAGAAAAATACGCTCCAACTTATATG
AATTGGAGCTTAGTAGGATCAGACAGTCATATTTGTGGAGGAACCCTTAT
CAACTCTGAATGGATAGTAACTGCTCAACATTGTCTATACTACAATTTTT
CTCCACAAGCAATCGCCATTACTGCGAATTGGTCTGCAACTTTGGGTGCC
TACGACATCAGTGGCTATTCTCAGCATTCTATATCCATTAAAATAGATAA
AGTAATTTTCCAAGAAAATTCTTTTGGAATGGATCTAGACGACAATGATT
TCGCAATGATGCATTTAAGTACAGCAGTCAATTTTACAGATTATATCTAC
CCGGCTTGTTTACCAACAAATCCTCTTGCCACCCCTGGAAATATATGCTA
CGCAGTTGGTTGGGGGACCTCGTATTCTCTCAATGAAACTACAAATCTCG
ATGATGGCTTATCCCCGGGGCATGCTCTTGTCAATCCAATTTTGAAACAC
GCGACTTTGCTAATAAGAGAAAGAAAAGAGAGCAAAGCGTGCAACACTCA
AACAGTGAAAGAAATTTGCACCTCCCCTCTGTCAGGATCTGTTTGTAGGG
GTGATTCTGGTGGGCCATTATTATGCCAAGGAGAAAACCAAAGTTGGATA
TTTGTCGGAATCACTGTCCGAGGATCGGGATGTCAGAAAAAAACTGACCG
GAGCATATTCACCAGTGTTTATCACTATCTAGATTTCCTAGTCCAAACGA
TGAATCACAGTCCGAAGAATGTAAAAATCCCAATTTATCATTTACAAATA
ATATTTACAATTTTTGTCACTTTTTTAGTCTTCCTGTTGTGATTTCGATC
TTATGAATGTTGACGGTTTTTCTAGATTTTAGTAAATCCATTGATTGTTT
TTTTTATTATGTATTTTTGGTGTTTAAATGTGCTCCGTGAAATAATTCAA
AAGAAAGATACATAATAAGTGATGGTTTCCATTCAATATGGTGGAGGTCC
GACAATTGAGCAGCAACGGGCGTTTTGTAATCCTCCGGAAGGAAGTCACA
TTCCCGGCTATCTTGGATTCATTCCACAAGCTAAATTTGAAGTCGGCAAA
ACGTTTGCCCGGGAATCTCACGATGTCGCTCGTAAACTTCCTTATTACAA
CGGTCCAAGAAATGCAAGTGTAAAACACTTCTATCCGGAAGTTGGAAAGA
CTAAAGACTGTGAAAATCGATCAATTTTTCAAGATGAGTTTCCAAAGAAC
AAATTACCGATTCCGACCGGAGATAATAAATATACGGAAAAAATGATGCC
CGGATATTCCGGTGATATTCCTCATTGGAATTATAAATTTGGTGGAACAT
ATCGCAGCATTTGTGATGAGGCAGTCAATGAATTTATTACGGACTATGAA
AGAAATGAAGCAAAAATGAACGATATCAAAAAGATGGCAAGCATGTTTCC
AAAGCTTCGCCCGATATGTTCAGATTTACGAGTGAAAGATCACATGAATC
TTTGGAGTGATAATTTAACCAAAATGTCGACATTGGCCAGTGACAGGAGG
CATATTCTTGAGCCTCCTATACCGGGTTACACAGGCTTTGTACCACGCAA
GGATAACACTGAAGTCGGACTTGGAAACCGATATCACGAAGCAGCAAAGC
ATTGCTTTGAATCTTTTGTTACTGAAAACAGTCGCCACTTCCAAAAACTG
GAAGAACCGATGAAAGTGAAAAACAACACTTACACCGTCCAAGATCAGAA
GTCCCTAGTTGTTTCCGTCCCAAGTAAAGTGGCATATAGCAGAAGGATAT
TCGTCCAAGATGGAATGATTCCGGGATACACGGGACATTTGCACGAAGAG
AAAGATGTTGACGGATACACTTACGGAGATAGCAGTCGGACCTTGAAGGT
CAGTCAGCATTCATTTCCGTGCTATGGAGATTATATTAAAAATATTGACC
TTGCTGCATGATCAAGGGTTTCTTGTTACCAATCGAGTTGTGAAATTGCC
TGTCGTTTCTATGATATGATAAACCGTATGAAATAATAGTAGAATATTAT
GCAAATAAATAAAACATGTAATAAATACATTTTTAACTTCCTCGAAA
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protein sequence of SMED30013024-orf-1

>SMED30013024-orf-1 ID=SMED30013024-orf-1|Name=SMED30013024-orf-1|organism=Schmidtea mediterranea sexual|type=polypeptide|length=330bp
MVSIQYGGGPTIEQQRAFCNPPEGSHIPGYLGFIPQAKFEVGKTFARESH
DVARKLPYYNGPRNASVKHFYPEVGKTKDCENRSIFQDEFPKNKLPIPTG
DNKYTEKMMPGYSGDIPHWNYKFGGTYRSICDEAVNEFITDYERNEAKMN
DIKKMASMFPKLRPICSDLRVKDHMNLWSDNLTKMSTLASDRRHILEPPI
PGYTGFVPRKDNTEVGLGNRYHEAAKHCFESFVTENSRHFQKLEEPMKVK
NNTYTVQDQKSLVVSVPSKVAYSRRIFVQDGMIPGYTGHLHEEKDVDGYT
YGDSSRTLKVSQHSFPCYGDYIKNIDLAA*
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protein sequence of SMED30013024-orf-2

>SMED30013024-orf-2 ID=SMED30013024-orf-2|Name=SMED30013024-orf-2|organism=Schmidtea mediterranea sexual|type=polypeptide|length=351bp
MNLNPILMIFISCSIKLFSGTKYNLTQIPCGKQMIEKSPQSNNTKIINRY
RRIVSGVNSYYGEWPWIASLKNPVLKELIEKYAPTYMNWSLVGSDSHICG
GTLINSEWIVTAQHCLYYNFSPQAIAITANWSATLGAYDISGYSQHSISI
KIDKVIFQENSFGMDLDDNDFAMMHLSTAVNFTDYIYPACLPTNPLATPG
NICYAVGWGTSYSLNETTNLDDGLSPGHALVNPILKHATLLIRERKESKA
CNTQTVKEICTSPLSGSVCRGDSGGPLLCQGENQSWIFVGITVRGSGCQK
KTDRSIFTSVYHYLDFLVQTMNHSPKNVKIPIYHLQIIFTIFVTFLVFLL
*
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Annotated Terms
The following terms have been associated with this transcript:
Vocabulary: cellular component
TermDefinition
GO:0005737cytoplasm
GO:0005886plasma membrane
GO:0005887integral component of plasma membrane
GO:0005911cell-cell junction
GO:0009986cell surface
GO:0005783endoplasmic reticulum
GO:0005789endoplasmic reticulum membrane
GO:0016020membrane
GO:0016021integral component of membrane
GO:0043025neuronal cell body
Vocabulary: biological process
TermDefinition
GO:0008360regulation of cell shape
GO:0010628positive regulation of gene expression
GO:0010719negative regulation of epithelial to mesenchymal transition
GO:0010756positive regulation of plasminogen activation
GO:0030307positive regulation of cell growth
GO:0034769basement membrane disassembly
GO:0043066negative regulation of apoptotic process
GO:0043923positive regulation by host of viral transcription
GO:0050680negative regulation of epithelial cell proliferation
GO:0050910detection of mechanical stimulus involved in sensory perception of sound
GO:0071805potassium ion transmembrane transport
GO:0090103cochlea morphogenesis
GO:0097066response to thyroid hormone
GO:0097195pilomotor reflex
GO:2000347positive regulation of hepatocyte proliferation
GO:2000611positive regulation of thyroid hormone generation
GO:0006508proteolysis
GO:0006883cellular sodium ion homeostasis
GO:0006898receptor-mediated endocytosis
GO:0007605sensory perception of sound
GO:0065009regulation of molecular function
Vocabulary: molecular function
TermDefinition
GO:0070008serine-type exopeptidase activity
GO:0004252serine-type endopeptidase activity
GO:0005044scavenger receptor activity
GO:0008233peptidase activity
GO:0008236serine-type peptidase activity
GO:0016787hydrolase activity
GO:0017080sodium channel regulator activity
Vocabulary: Planarian Anatomy
TermDefinition
PLANA:0000070intestinal phagocyte
PLANA:0000099neuron
PLANA:0000418head
PLANA:0002089reproductive organ
PLANA:0003116parenchymal cell
Vocabulary: INTERPRO
TermDefinition
IPR001314Peptidase_S1A
IPR001254Trypsin_dom
IPR033116TRYPSIN_SER
IPR009003Peptidase_S1_PA
IPR018902FAM166/UPF0605
IPR003323OTU_dom
InterPro
Analysis Name: Schmidtea mediteranean smed_20140614 Interproscan
Date Performed: 2020-05-01
IPR TermIPR DescriptionSourceSource TermSource DescriptionAlignment
IPR001314Peptidase S1A, chymotrypsin familyPRINTSPR00722CHYMOTRYPSINcoord: 266..278
score: 58.85
coord: 166..180
score: 26.7
coord: 100..115
score: 53.06
IPR001254Serine proteases, trypsin domainSMARTSM00020trypsin_2coord: 52..317
e-value: 3.3E-46
score: 169.5
IPR001254Serine proteases, trypsin domainPFAMPF00089Trypsincoord: 53..316
e-value: 1.4E-39
score: 136.1
IPR001254Serine proteases, trypsin domainPROSITEPS50240TRYPSIN_DOMcoord: 53..322
score: 25.598
IPR001254Serine proteases, trypsin domainCDDcd00190Tryp_SPccoord: 53..320
e-value: 7.72794E-53
score: 172.461
NoneNo IPR availableGENE3DG3DSA:2.40.10.10coord: 130..211
e-value: 5.6E-14
score: 53.8
NoneNo IPR availableGENE3DG3DSA:2.40.10.10coord: 231..324
e-value: 1.2E-17
score: 65.8
NoneNo IPR availableGENE3DG3DSA:2.40.10.10coord: 53..116
e-value: 1.4E-15
score: 59.0
NoneNo IPR availablePANTHERPTHR24253FAMILY NOT NAMEDcoord: 15..322
NoneNo IPR availableSIGNALP_EUKSignalP-noTMSignalP-noTMcoord: 1..20
score: 0.466
NoneNo IPR availableTMHMMTMhelixcoord: 330..349
IPR033116Serine proteases, trypsin family, serine active sitePROSITEPS00135TRYPSIN_SERcoord: 267..278
IPR009003Peptidase S1, PA clanSUPERFAMILYSSF50494Trypsin-like serine proteasescoord: 49..323