NEPH-2

Overview


Name	NEPH-2 (AKN21715.1)
Smed ID	SMED30012867
Length (bp)	3052

Neoblast Clusters

▻ Sub-lethal Irradiated Surviving X1 and X2 Cell Population

Overview

Single cell RNA-seq of pluripotent neoblasts and its early progenies

We isolated X1 neoblasts cells enriched in high piwi-1 expression (Neoblast Population), and profiled ∼7,614 individual cells via scRNA-seq. Unsupervised analyses uncovered 12 distinct classes from 7,088 high-quality cells. We designated these classes Nb1 to Nb12 and ordered them based on high (Nb1) to low (Nb12) piwi-1 expression levels. We further defined groups of genes that best classified the cells parsed into 12 distinct cell clusters to generate a scaled expression heat map of discriminative gene sets for each cluster. Expression of each cluster’s gene signatures was validated using multiplex fluorescence in situ hybridization (FISH) co-stained with piwi-1 and largely confirmed the cell clusters revealed by scRNA-seq.

We also tested sub-lethal irradiation exposure. To profile rare pluripotent stem cells (PSCs) and avoid interference from immediate progenitor cells, we determined a time point after sub-lethal irradiation (7 DPI) with minimal piwi-1+ cells, followed by isolation and single-cell RNA-seq of 1,200 individual cells derived from X1 (Piwi-1 high) and X2 (Piwi-1 low) cell populations (Sub-lethal Irradiated Surviving X1 and X2 Cell Population)

Explore this single cell expression dataset with our NB Cluster Shiny App

Neoblast Population

t-SNE plot shows two-dimensional representation of global gene expression relationships among all neoblasts (n = 7,088 after filter). Cluster identity was assigned based on the top 10 marker genes of each cluster (Table S2), followed by inspection of RNA in situ hybridization patterns. Neoblast groups, Nb.

Expression of NEPH-2 (SMED30012867) t-SNE clustered cells

Violin plots show distribution of expression levels for NEPH-2 (SMED30012867) in cells (dots) of each of the 12 neoblast clusters.

Sub-lethal Irradiated Surviving X1 and X2 Cell Population

t-SNE plot of surviving X1 and X2 cells (n = 1,039 after QC filter) after sub-lethal irradiation. Colors indicate unbiased cell classification via graph-based clustering. SL, sub-lethal irradiated cell groups.

Expression of NEPH-2 (SMED30012867) in the t-SNE clustered sub-lethally irradiated X1 and X2 cells.

Violin plots show distribution of expression levels for NEPH-2 (SMED30012867) in cells (dots) of each of the 10 clusters of sub-leathally irradiated X1 and X2 cells.

Embryonic Expression

Davies et. al., 2017

Hover the mouse over a column in the graph to view average RPKM values per sample.
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Embryonic Stages: Y: yolk. S2-S8: Stages 2-8. C4: asexual adult. SX: virgin, sexually mature adult.
For further information about sample preparation and analysis for the single animal RNA-Seq experiment, please refer to the Materials and Methods

Anatomical Expression

PAGE et. al., 2020

SMED30012867

has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGE

PAGE Curations: 5

Expressed In	Reference Transcript	Gene Models	Published Transcript	Transcriptome	Publication
nervous system	SMED30012867	SMESG000071657.1	dd_Smed_v4_12118_0_1	dd_Smed_v4	PMID:29674431 Fincher et al., 2018
epidermis	SMED30012867	SMESG000071657.1	dd_Smed_v4_12118_0_1	dd_Smed_v4	PMID:29674431 Fincher et al., 2018
cephalic ganglia	SMED30012867	SMESG000071657.1	dd_Smed_v4_12118_0_1	dd_Smed_v4	PMID:29674431 Fincher et al., 2018
anterior side	SMED30012867	SMESG000071657.1	dd_Smed_v4_12118_0_1	dd_Smed_v4	PMID:29674431 Fincher et al., 2018
muscle cell	SMED30012867	SMESG000071657.1	dd_Smed_v4_12118_0_1	dd_Smed_v4	PMID:29674431 Fincher et al., 2018

Note: Hover over icons to view figure legend

Homology

[Close]

BLAST of NEPH-2 vs. Ensembl Human
Match: KIRREL3 (kirre like nephrin family adhesion molecule 3 [Source:HGNC Symbol;Acc:HGNC:23204])

HSP 1 Score: 162.54 bits (410), Expect = 1.759e-40
Identity = 135/522 (25.86%), Postives = 226/522 (43.30%), Query Frame = 3

Query:  456 HPENQRVTLNSTVTIQCRVQPIKNMKVYWVKSGFGLGETRSDIRSFGMVGNKVRYDIPNDLSAGNYDLQITDVNLEDEGDFYCQMNIKNNAITSQRAQLHVLVASGPPKIIQIGNQGMGPEKLRNENSPIVVDNGDLMALRCQAERGRPGARLTWMIDNEIIEPDLSGNFNGIISGTITNISKKIVNNTKLRDSFSTLKAKVNQLLNGKSIKCSATNRGFEKFNFPEAKAKIEIHVAPTVTMDIVSQNLGNEFSENDWITISCSALGRPDKFLWKWYINDNEVMNDNRSSYKIKATRTMNKAVVKCIANNGKEGHDL-RMLNVKYGPQFKDDSPPLYPANIGDDVTLTCNTDSNPMANIYWQRESNNDIIGHGTILYRKNIQELDFGTYICTAGVENFDLKSKKIILAKRIKPMIRENPDHRASLGRSVQAKCVIDSIPIANHNQIMWLYRGRRLINDNT-KYSISTEKYVDHSISILSINNIQASDFGQ-YNCSVTTDLGSASKVMVLSKTSPIPLILIVG 2012
             P++Q V     VT+ C + P  +  V W+K G  LG  R D+ S+       +Y +  +  +G + L+I    L+D+  + CQ      AI S+ A+L VLV    P I+       GP         I +  GD + L C A+  +P A + W+   E+I        NG         SK ++ + K     STL      + NG+SI C ATN+        E    I+I   P V + +  Q +     E++ +T  CSA   P    ++W      +   +   Y+     T     V C   N     +L R ++V +GP+   +   L   ++G D   +C    NP   I W +  +  ++ +   L  K++++ D G Y+C A V       +++ L     P+I       A  G   Q KC I S P    ++I W ++   L +  + +Y++ T    +  IS L+I+NI  +DF   YNC+     GS ++++ L +   +P+ +I+G
Sbjct:   53 QPQDQVVVSGQPVTLLCAI-PEYDGFVLWIKDGLALGVGR-DLSSYP------QYLVVGNHLSGEHHLKILRAELQDDAVYECQA--IQAAIRSRPARLTVLVPPDDPVILG------GPV--------ISLRAGDPLNLTCHADNAKPAASIIWLRKGEVI--------NG------ATYSKTLLRDGKRESIVSTLFISPGDVENGQSIVCRATNKAIPGGK--ETSVTIDIQHPPLVNLSVEPQPV----LEDNVVTFHCSAKANPAVTQYRWAKRGQIIKEASGEVYRTTVDYTYFSEPVSCEVTNALGSTNLSRTVDVYFGPRMTTEPQSLL-VDLGSDAIFSCAWTGNPSLTIVWMKRGSGVVLSNEKTLTLKSVRQEDAGKYVCRAVVPRVGAGEREVTLTVNGPPIISSTQTQHALHGEKGQIKCFIRSTP--PPDRIAWSWKENVLESGTSGRYTVETISTEEGVISTLTISNIVRADFQTIYNCTAWNSFGSDTEIIRLKEQESVPMAVIIG 527

[Close]

BLAST of NEPH-2 vs. Ensembl Human
Match: KIRREL1 (kirre like nephrin family adhesion molecule 1 [Source:HGNC Symbol;Acc:HGNC:15734])

HSP 1 Score: 156.377 bits (394), Expect = 1.447e-38
Identity = 126/532 (23.68%), Postives = 222/532 (41.73%), Query Frame = 3

Query:  432 GNENYINVHPENQRVTLNSTVTIQCRVQPIKNMKVYWVKSGFGLGETRSDIRSFGMVGNKVRYDIPNDLSAGNYDLQITDVNLEDEGDFYCQMNIKNNAITSQRAQLHVLVASGPPKIIQIGNQGMGPEKLRNENSPIVV-DNGDLMALRCQAERGRPGARLTWMIDNEIIEPDLSGNFNGIISGTITNISKKIVNNTKLRDSFSTLKAKVNQLLNGKSIKCSATNRGFEKFNFPEAKAKIEIHVAPTVTMDIVSQNLGNEFSENDWITISCSALGRPDKFLWKWYINDNEVMNDNRSSYKIKATRTMNKAVVKCIANNGKEGHDLRML-NVKYGPQFKDDSPPLYPANIGDDVTLTCNTDSNPMANIYWQRESNNDIIGHGTILYRKNIQELDFGTYICTAGVENFDLKSKKIILAKRIKPMIRENPDHRASLGRSVQAKCVIDSIPIANHNQIMWLYRGRRL-INDNTKYSISTEKYVDHSISILSINNIQASDF-GQYNCSVTTDLGSASKVMVLSKTSPIPLILIVGG 2015
            G +   +  P +Q V       + C +     + V W K G  LG  +  ++++       RY +     AG Y+L+ITD  L D+  + CQ      A+ S+RA+L VL+                PE  R +  P+++   G    L C+A   +P A + W  D    E        G ++ T      +++ + K   + S L      L  G+   C + N         E   ++++H  PTVT+ I  Q +     E + +  +C A   P+   ++W      + + + S Y+     +     V C  +N     ++  L NV + P+   D  P    +IG DVTLTC    NP   + W ++ +N ++ +   L  K++ + D GTY C A V    +  +++ L     P+I       A  G   + +C I S P    ++I W ++   L +    +Y++         +S L+INN+  +DF   YNC+     G  + ++ L +   +P+ +I G 
Sbjct:   18 GTQTRFSQEPADQTVVAGQRAVLPCVLLNYSGI-VQWTKDGLALGMGQG-LKAWP------RYRVVGSADAGQYNLEITDAELSDDASYECQAT--EAALRSRRAKLTVLIP---------------PEDTRIDGGPVILLQAGTPHNLTCRAFNAKPAATIIWFRDGTQQE--------GAVAST------ELLKDGKRETTVSQLLINPTDLDIGRVFTCRSMNEAIPSGK--ETSIELDVHHPPTVTLSIEPQTV----QEGERVVFTCQATANPEILGYRWAKGGFLIEDAHESRYETNVDYSFFTEPVSCEVHNKVGSTNVSTLVNVHFAPRIVVDPKPT-TTDIGSDVTLTCVWVGNPPLTLTWTKKDSNMVLSNSNQLLLKSVTQADAGTYTCRAIVPRIGVAEREVPLYVNGPPIISSEAVQYAVRGDGGKVECFIGSTPPP--DRIAWAWKENFLEVGTLERYTVERTNSGSGVLSTLTINNVMEADFQTHYNCTAWNSFGPGTAIIQLEEREVLPVGIIAGA 501

[Close]

BLAST of NEPH-2 vs. Ensembl Human
Match: KIRREL3 (kirre like nephrin family adhesion molecule 3 [Source:HGNC Symbol;Acc:HGNC:23204])

HSP 1 Score: 153.295 bits (386), Expect = 4.487e-38
Identity = 135/534 (25.28%), Postives = 226/534 (42.32%), Query Frame = 3

Query:  456 HPENQRVTLNSTVTIQCRVQPIKNMKVYWVKSGFGLGETRSDIRSFGMVGNKVRYDIPNDLSAGNYDLQITDVNLEDEGDFYCQMNIKNNAITSQRAQLHVLVASGPPKIIQIGNQGMGPEKLRNENSPIVVDNGDLMALRCQAERGRPGARLTWMIDNEIIEPDLSGNFNGIISGTITNISKKIVNNTKLRDSFSTLKAKVNQLLNGKSIKCSATNRGFEKFNFPEAKAKIEIHVAPTVTMDIVSQNLGNEFSENDWITISCSALGRPDKFLWKWYINDNEVMNDNRSSYKIKATRTMNKAVVKCIANNGKEGHDL-RMLNVKYGPQFKDDSPPLYPANIGDDVTLTCNTDSNPMANIYWQRESNNDIIGHGTILYRKNIQELDFGTYICTAGVENFDLKSKKIILAKRIKPMIRENPDHRASLGRSVQAKCVIDSIPIANHNQIMWLYRGRRLINDNT-KYSISTEKYVDHSISILSINNIQASDFGQ-YNCSVTTDLGSASKVMVLS------------KTSPIPLILIVG 2012
             P++Q V     VT+ C + P  +  V W+K G  LG  R D+ S+       +Y +  +  +G + L+I    L+D+  + CQ      AI S+ A+L VLV    P I+       GP         I +  GD + L C A+  +P A + W+   E+I        NG         SK ++ + K     STL      + NG+SI C ATN+        E    I+I   P V + +  Q +     E++ +T  CSA   P    ++W      +   +   Y+     T     V C   N     +L R ++V +GP+   +   L   ++G D   +C    NP   I W +  +  ++ +   L  K++++ D G Y+C A V       +++ L     P+I       A  G   Q KC I S P    ++I W ++   L +  + +Y++ T    +  IS L+I+NI  +DF   YNC+     GS ++++ L             +   +P+ +I+G
Sbjct:   53 QPQDQVVVSGQPVTLLCAI-PEYDGFVLWIKDGLALGVGR-DLSSYP------QYLVVGNHLSGEHHLKILRAELQDDAVYECQA--IQAAIRSRPARLTVLVPPDDPVILG------GPV--------ISLRAGDPLNLTCHADNAKPAASIIWLRKGEVI--------NG------ATYSKTLLRDGKRESIVSTLFISPGDVENGQSIVCRATNKAIPGGK--ETSVTIDIQHPPLVNLSVEPQPV----LEDNVVTFHCSAKANPAVTQYRWAKRGQIIKEASGEVYRTTVDYTYFSEPVSCEVTNALGSTNLSRTVDVYFGPRMTTEPQSLL-VDLGSDAIFSCAWTGNPSLTIVWMKRGSGVVLSNEKTLTLKSVRQEDAGKYVCRAVVPRVGAGEREVTLTVNGPPIISSTQTQHALHGEKGQIKCFIRSTP--PPDRIAWSWKENVLESGTSGRYTVETISTEEGVISTLTISNIVRADFQTIYNCTAWNSFGSDTEIIRLKEQGSEMKSGAGLEAESVPMAVIIG 539

[Close]

BLAST of NEPH-2 vs. Ensembl Human
Match: KIRREL3 (kirre like nephrin family adhesion molecule 3 [Source:HGNC Symbol;Acc:HGNC:23204])

HSP 1 Score: 154.451 bits (389), Expect = 7.649e-38
Identity = 135/534 (25.28%), Postives = 226/534 (42.32%), Query Frame = 3

Query:  456 HPENQRVTLNSTVTIQCRVQPIKNMKVYWVKSGFGLGETRSDIRSFGMVGNKVRYDIPNDLSAGNYDLQITDVNLEDEGDFYCQMNIKNNAITSQRAQLHVLVASGPPKIIQIGNQGMGPEKLRNENSPIVVDNGDLMALRCQAERGRPGARLTWMIDNEIIEPDLSGNFNGIISGTITNISKKIVNNTKLRDSFSTLKAKVNQLLNGKSIKCSATNRGFEKFNFPEAKAKIEIHVAPTVTMDIVSQNLGNEFSENDWITISCSALGRPDKFLWKWYINDNEVMNDNRSSYKIKATRTMNKAVVKCIANNGKEGHDL-RMLNVKYGPQFKDDSPPLYPANIGDDVTLTCNTDSNPMANIYWQRESNNDIIGHGTILYRKNIQELDFGTYICTAGVENFDLKSKKIILAKRIKPMIRENPDHRASLGRSVQAKCVIDSIPIANHNQIMWLYRGRRLINDNT-KYSISTEKYVDHSISILSINNIQASDFGQ-YNCSVTTDLGSASKVMVLS------------KTSPIPLILIVG 2012
             P++Q V     VT+ C + P  +  V W+K G  LG  R D+ S+       +Y +  +  +G + L+I    L+D+  + CQ      AI S+ A+L VLV    P I+       GP         I +  GD + L C A+  +P A + W+   E+I        NG         SK ++ + K     STL      + NG+SI C ATN+        E    I+I   P V + +  Q +     E++ +T  CSA   P    ++W      +   +   Y+     T     V C   N     +L R ++V +GP+   +   L   ++G D   +C    NP   I W +  +  ++ +   L  K++++ D G Y+C A V       +++ L     P+I       A  G   Q KC I S P    ++I W ++   L +  + +Y++ T    +  IS L+I+NI  +DF   YNC+     GS ++++ L             +   +P+ +I+G
Sbjct:   53 QPQDQVVVSGQPVTLLCAI-PEYDGFVLWIKDGLALGVGR-DLSSYP------QYLVVGNHLSGEHHLKILRAELQDDAVYECQA--IQAAIRSRPARLTVLVPPDDPVILG------GPV--------ISLRAGDPLNLTCHADNAKPAASIIWLRKGEVI--------NG------ATYSKTLLRDGKRESIVSTLFISPGDVENGQSIVCRATNKAIPGGK--ETSVTIDIQHPPLVNLSVEPQPV----LEDNVVTFHCSAKANPAVTQYRWAKRGQIIKEASGEVYRTTVDYTYFSEPVSCEVTNALGSTNLSRTVDVYFGPRMTTEPQSLL-VDLGSDAIFSCAWTGNPSLTIVWMKRGSGVVLSNEKTLTLKSVRQEDAGKYVCRAVVPRVGAGEREVTLTVNGPPIISSTQTQHALHGEKGQIKCFIRSTP--PPDRIAWSWKENVLESGTSGRYTVETISTEEGVISTLTISNIVRADFQTIYNCTAWNSFGSDTEIIRLKEQGSEMKSGAGLEAESVPMAVIIG 539

[Close]

BLAST of NEPH-2 vs. Ensembl Human
Match: KIRREL1 (kirre like nephrin family adhesion molecule 1 [Source:HGNC Symbol;Acc:HGNC:15734])

HSP 1 Score: 123.25 bits (308), Expect = 3.170e-28
Identity = 95/405 (23.46%), Postives = 171/405 (42.22%), Query Frame = 3

Query:  813 PEKLRNENSPIVV-DNGDLMALRCQAERGRPGARLTWMIDNEIIEPDLSGNFNGIISGTITNISKKIVNNTKLRDSFSTLKAKVNQLLNGKSIKCSATNRGFEKFNFPEAKAKIEIHVAPTVTMDIVSQNLGNEFSENDWITISCSALGRPDKFLWKWYINDNEVMNDNRSSYKIKATRTMNKAVVKCIANNGKEGHDLRML-NVKYGPQFKDDSPPLYPANIGDDVTLTCNTDSNPMANIYWQRESNNDIIGHGTILYRKNIQELDFGTYICTAGVENFDLKSKKIILAKRIKPMIRENPDHRASLGRSVQAKCVIDSIPIANHNQIMWLYRGRRL-INDNTKYSISTEKYVDHSISILSINNIQASDF-GQYNCSVTTDLGSASKVMVLSKTSPIPLILIVGG 2015
            PE  R +  P+++   G    L C+A   +P A + W  D    E        G ++ T      +++ + K   + S L      L  G+   C + N         E   ++++H  PTVT+ I  Q +     E + +  +C A   P+   ++W      + + + S Y+     +     V C  +N     ++  L NV + P+   D  P    +IG DVTLTC    NP   + W ++ +N ++ +   L  K++ + D GTY C A V    +  +++ L     P+I       A  G   + +C I S P    ++I W ++   L +    +Y++         +S L+INN+  +DF   YNC+     G  + ++ L +   +P+ +I G 
Sbjct:   20 PEDTRIDGGPVILLQAGTPHNLTCRAFNAKPAATIIWFRDGTQQE--------GAVAST------ELLKDGKRETTVSQLLINPTDLDIGRVFTCRSMNEAIPSGK--ETSIELDVHHPPTVTLSIEPQTV----QEGERVVFTCQATANPEILGYRWAKGGFLIEDAHESRYETNVDYSFFTEPVSCEVHNKVGSTNVSTLVNVHFAPRIVVDPKPT-TTDIGSDVTLTCVWVGNPPLTLTWTKKDSNMVLSNSNQLLLKSVTQADAGTYTCRAIVPRIGVAEREVPLYVNGPPIISSEAVQYAVRGDGGKVECFIGSTPPP--DRIAWAWKENFLEVGTLERYTVERTNSGSGVLSTLTINNVMEADFQTHYNCTAWNSFGPGTAIIQLEEREVLPVGIIAGA 401

[Close]

BLAST of NEPH-2 vs. Ensembl Celegans
Match: syg-1 (Synaptogenesis protein syg-1 [Source:UniProtKB/Swiss-Prot;Acc:B1Q236])

HSP 1 Score: 142.124 bits (357), Expect = 1.736e-34
Identity = 143/553 (25.86%), Postives = 236/553 (42.68%), Query Frame = 3

Query:  459 PENQRVTLNSTVTIQCRVQPIKNMKVYWVKSGFGLGETRSDIRSFGMVGNKVRYDIPNDLSAGNYDLQITDVNLEDEGDFYCQMNIKNNA--ITSQRAQLHVLVASGPPKIIQIGNQGMGPEKLRNENSPIVVDNGDLMALRCQAERGRPGARLTWMIDNEIIEPDLSGNFNGIISGTITNISKKIVNNTKLRDSFSTLKAKVN---QLLNG-------KSIKCSATNRGF---------------EKFNFPEA----KAKIEIHVAPTVTMDIVSQNLGNEFSENDWITISCSALGRP-DKFLWKWYINDNEVMNDNRS-SYKIKATRTMNKAVVKCIANN--GKEGHDLRMLNVKYGPQFKDDSPPLYPANIGDDVTLTCNTDSNPMANIYWQRESNNDIIGHGTILYRKNIQELDFGTYICTAGVENFDLKSKKIILAKRIKPMIRENPDHRASLGRSVQAKCVIDSIPIANHNQIMWLYRGRRLINDNTKYSISTEKYVDHSISILSINNIQASDFGQYNCSVTTDLGSASKVMVLSKTSPIPLILIVG 2012
            P++    +  T  + CRV+  +   V W+K  FGLG  R       + GNK RY +    + G Y+L+I++V L D+ DF CQ++  ++A  + S +A+L VLV   PPKI++              +  +    GD +   C + +G+P   + W I +     D  G    I+S    + SK    + K   S  T+ A VN   Q+  G        SI    +N  F               +   FP        K+ +  AP + + + S+       EN    ++C+   +P D     WY  + ++     + +++       N+ +  C A N  G     ++ LNV +G +    S      N GD+    C T +NP   I+W R  +++IIGHG  L  +N++    G Y CTA VE F  +     L  R  P +    +  ASL  + +  C I   P  N+  + W   G+ +  +N + ++          SIL I +++  DFG YNCS    LG  ++  +L K + +  I+I  
Sbjct:   29 PKDTLAAVGETAILTCRVEH-QQGPVQWMKDDFGLGTDRDK----PLPGNK-RYRMVGSAANGEYNLEISNVTLFDDDDFACQISESDHAKAVVSSKAKLTVLVRPTPPKIVK-------------SHHSLKAIAGDPITQSCLSRKGKPPPTIGWAIAS-----DEHGKH--IVSWLGESRSKFGGIHAKPEISQETVIAHVNETTQVEEGGNNSREDSSIYSIMSNLSFIPRPEDDHKYLICISQHMTFPNKIEVDSVKLSLRYAPQINLTVASKL---PLRENGSALLACNVNAKPLDNVKISWYKGNQKLRETGDTLTFETLKMEDHNRDIF-CEATNEIGTTRGSIK-LNVAFGARIMSTSQD-KEVNEGDNAFFHCATLANPAPAIFWTRGDSDEIIGHGENLTLENVRTWQQGNYNCTATVEGFRKQILSHYLHIRGPPTVSMKDEVSASLDEATEIICEISGRPKTNN--VRWTVNGKEINFNNGRITVHQYPKPYGKESILKIKDLKEEDFGVYNCSANNGLGFDNRGTLLKKRNILDWIVITA 547

[Close]

BLAST of NEPH-2 vs. Ensembl Celegans
Match: syg-1 (Synaptogenesis protein syg-1 [Source:UniProtKB/Swiss-Prot;Acc:B1Q236])

HSP 1 Score: 141.739 bits (356), Expect = 2.154e-34
Identity = 143/553 (25.86%), Postives = 236/553 (42.68%), Query Frame = 3

Query:  459 PENQRVTLNSTVTIQCRVQPIKNMKVYWVKSGFGLGETRSDIRSFGMVGNKVRYDIPNDLSAGNYDLQITDVNLEDEGDFYCQMNIKNNA--ITSQRAQLHVLVASGPPKIIQIGNQGMGPEKLRNENSPIVVDNGDLMALRCQAERGRPGARLTWMIDNEIIEPDLSGNFNGIISGTITNISKKIVNNTKLRDSFSTLKAKVN---QLLNG-------KSIKCSATNRGF---------------EKFNFPEA----KAKIEIHVAPTVTMDIVSQNLGNEFSENDWITISCSALGRP-DKFLWKWYINDNEVMNDNRS-SYKIKATRTMNKAVVKCIANN--GKEGHDLRMLNVKYGPQFKDDSPPLYPANIGDDVTLTCNTDSNPMANIYWQRESNNDIIGHGTILYRKNIQELDFGTYICTAGVENFDLKSKKIILAKRIKPMIRENPDHRASLGRSVQAKCVIDSIPIANHNQIMWLYRGRRLINDNTKYSISTEKYVDHSISILSINNIQASDFGQYNCSVTTDLGSASKVMVLSKTSPIPLILIVG 2012
            P++    +  T  + CRV+  +   V W+K  FGLG  R       + GNK RY +    + G Y+L+I++V L D+ DF CQ++  ++A  + S +A+L VLV   PPKI++              +  +    GD +   C + +G+P   + W I +     D  G    I+S    + SK    + K   S  T+ A VN   Q+  G        SI    +N  F               +   FP        K+ +  AP + + + S+       EN    ++C+   +P D     WY  + ++     + +++       N+ +  C A N  G     ++ LNV +G +    S      N GD+    C T +NP   I+W R  +++IIGHG  L  +N++    G Y CTA VE F  +     L  R  P +    +  ASL  + +  C I   P  N+  + W   G+ +  +N + ++          SIL I +++  DFG YNCS    LG  ++  +L K + +  I+I  
Sbjct:   29 PKDTLAAVGETAILTCRVEH-QQGPVQWMKDDFGLGTDRDK----PLPGNK-RYRMVGSAANGEYNLEISNVTLFDDDDFACQISESDHAKAVVSSKAKLTVLVRPTPPKIVK-------------SHHSLKAIAGDPITQSCLSRKGKPPPTIGWAIAS-----DEHGKH--IVSWLGESRSKFGGIHAKPEISQETVIAHVNETTQVEEGGNNSREDSSIYSIMSNLSFIPRPEDDHKYLICISQHMTFPNKIEVDSVKLSLRYAPQINLTVASKL---PLRENGSALLACNVNAKPLDNVKISWYKGNQKLRETGDTLTFETLKMEDHNRDIF-CEATNEIGTTRGSIK-LNVAFGARIMSTSQD-KEVNEGDNAFFHCATLANPAPAIFWTRGDSDEIIGHGENLTLENVRTWQQGNYNCTATVEGFRKQILSHYLHIRGPPTVSMKDEVSASLDEATEIICEISGRPKTNN--VRWTVNGKEINFNNGRITVHQYPKPYGKESILKIKDLKEEDFGVYNCSANNGLGFDNRGTLLKKRNILDWIVITA 547

[Close]

BLAST of NEPH-2 vs. Ensembl Celegans
Match: him-4 (High Incidence of Males (Increased X chromosome loss) [Source:UniProtKB/TrEMBL;Acc:A4UVK0])

HSP 1 Score: 77.411 bits (189), Expect = 5.935e-14
Identity = 110/527 (20.87%), Postives = 192/527 (36.43%), Query Frame = 3

Query:  489 TVTIQCRVQPIKNMKVYWVKSGFGLGETRSDIRSFGMVGNKVRYDIPNDLSAGNYDLQITDVNLEDEGDFYCQMNIKNNAITSQRAQLHVLVASGPPKIIQIGNQGMGPEKLRNENSPIVVDNGDLMALRCQAERGRPGAR----LTWMIDNEIIEPDLSGNFNGIISGTITNISKKIVNNTKL-------RDSFSTLKAKVNQLLNG-KSIKCSATNRGFEKFNFPEAKAKIE-----IHVAPTVTMDIVSQNLGNEFSENDWITISCSALGRPDKFLWKWYINDNEVMNDNR-------SSYKIKATRTMNKAVVKCIANNGKEGHDLRMLNVKYGP---QFKDDSPPLYPANIGDDVTLTCNTDSNPMANIYWQRESN--------NDIIGHGTILYRKNIQELDFGTYIC----TAGVENFDLKSKKIILAKRIKPMIRENPDHRASLGRSVQAKCVIDSIPIANHNQIMWLYRGRRLINDNTKYSISTEKYVDHSISILSINNIQASDFGQYNCSVTTDLGS 1952
            T+ ++C +  I    V W K+G  +  T S +                 L+  N    I +V + D+G + C    +     S    L VL    PP+    G Q            P +   GD + L C  +     A     ++W  D+  ++ DL+ N +    G    IS+  + N  L       R   ++L+ KV  L     ++KC      +   + P    K        +  P   +DI   ++  + + N    + C+  G P   + KW  N  EV +D            +I  T + +     C+A N     +L M+   + P     K D+P      +G+ +TL CN   NP   + W +  +          I   G  L   ++++ D G Y C     AG     +    ++  +  +  I  +P  R    +S+  +C+    P+    Q+ W   G  L +     +++++       + + INN+  SD G Y C      GS
Sbjct: 3591 TIYLECPISGIPQPDVIWTKNGMDINMTDSRVI----------------LAQNNETFGIENVQVTDQGRYTCTATNRGGK-ASHDFSLDVL---SPPEFDIHGTQ------------PTIKREGDTITLTCPIKLAEDIADQVMDVSWTKDSRALDGDLTDNVDISDDGRKLTISQASLENAGLYTCIALNRAGEASLEFKVEILCTSLATVKCREHENNYIARHMPHVVTKPREMSQSANAYPPPVIDISRNDVQPQVAVNQPTIMRCAVTGHPFPSI-KWLKNGKEVTDDENIRIVEQGQVLQILRTDSDHAGKWSCVAENDAGVKELEMVLDVFTPPVVSVKSDNPI---KALGETITLFCNASGNPYPQLKWAKGGSLIFDSPDGARISLKGARLDIPHLKKTDVGDYTCQALNAAGTSEASVSVDVLVPPEINRDGIDMSP--RLPAQQSLTLQCLAQGKPVP---QMRWTLNGTALTHSTPGITVASDS------TFIQINNVSLSDKGVYTCYAENVAGS 4070

HSP 2 Score: 71.633 bits (174), Expect = 3.109e-12
Identity = 116/508 (22.83%), Postives = 191/508 (37.60%), Query Frame = 3

Query:  471 RVTLNSTVTIQCRVQPIKNMKVYWVKSGFGLGETRSDIRSFGMVGNKVRYDIPNDLSAGNYDLQITDVNLEDEGDFYCQMNIKNNAITSQRAQLHVLVA-SGPPKIIQIGNQGMGPEKLRNENSPIVVDNGDLMALRCQAERGRPGARLTWMIDNEIIEPDLSGNFNGIISGTITNISKKIVNNTKLRDSFSTLKAKVNQLLNGKSIKCSATNRGFEKFNFPEAKAKIEIHVAPTVTMD--IVSQNLGNEFSENDWITISCSALGRPDKFLWKWYINDNEVMNDNRSSYKIKATRTMNKAVVKCIANN--GKEGHDLRMLNVKYGPQFKDDSPPLYPANI--GDDVTLTCNTDSNPMANIYWQRES-----NNDIIG-HGTILYRKNIQELDFGTYICTAGVENFDLKSKKIILAKRIKPMIRENPDH--RASLGRSVQAKCVIDSIPIANHNQIMWLYRGRRLINDNTKYSISTEKYVDHSISILSINNIQASDFGQYNCSVTTDLG 1949
             +  ++T+ I CR + I   ++ W   G  + E         M G  V Y        G+  L+I ++    EG + C    K     + RA+    V  S PP+++      M  E +R       V  G    +RC+   G P   + W+ D E    DL                  +  +TKL    S L  +   L +G +  C ATN+  E     +    +E+ V P +  +  ++    GN +       + C   GRP  ++  W  N  E+   N   +   ATR  ++    CIA+N  G    D  +++V   P F+         NI  G+   + C  D +P   I W +       +N I+   G  L     Q  D G Y C A   ++    +   +    KP I E  D   +A  G  +  KC +    + N    +   RG   + ++++++I            L IN++   D GQY+C    + G
Sbjct: 3046 EIVADTTLEIPCRTEGIPPPEISWFLDGKPILE---------MPG--VTY------KQGDLSLRIDNIKPNQEGRYTCVAENK-----AGRAEQDTYVEISEPPRVV------MASEVMR-------VVEGRQTTIRCEV-FGNPEPVVNWLKDGEPYTSDL------------------LQFSTKL----SYLHLRETTLADGGTYTCIATNKAGES----QTTTDVEVLVPPRIEDEERVLQGKEGNTY------MVHCQVTGRPVPYV-TWKRNGKEIEQFNPVLHIRNATRA-DEGKYSCIASNEAGTAVADF-LIDVFTKPTFETHETTF---NIVEGESAKIECKIDGHPKPTISWLKGGRPFNMDNIILSPRGDTLMILKAQRFDGGLYTCVA-TNSYGDSEQDFKVNVYTKPYIDETIDQTPKAVAGGEIILKCPV----LGNPTPTVTWKRGDDAVPNDSRHTIVNNYD-------LKINSVTTEDAGQYSCIAVNEAG 3467

HSP 3 Score: 71.2478 bits (173), Expect = 3.743e-12
Identity = 89/342 (26.02%), Postives = 133/342 (38.89%), Query Frame = 3

Query: 1032 DSFSTLKAKVNQLLNGKSIKCSATNRGFEKFNFPEAKAKIEIHVAPTV--TMDIVSQNL-GNEFSENDWITISCSALGRPDKFLWKWYINDNEVMNDNRSS------YKIKATRTMNKAVVKCIANNGKEGHDLR---MLNVKYGPQFKDDSPPLYPANIGDDVTLTCNTDSNPMANIYWQRESN-------NDIIGHGTILYRKNIQELDFGTYIC----TAGVENFDLKSKKIILAKRIKPMIRENPDHRASLGRSVQAKCVIDSIPIANHNQIMWLYRGRRLINDNTKYSISTEKYVDHSISILSINNIQASDFGQYNCSVTTDLGSASKVMVLSKTSP 1988
            D+   LKA   Q  +G    C ATN     +   E   K+ ++  P +  T+D   + + G E      I + C  LG P   +  W   D+ V ND+R +       KI +  T +     CIA N  E  +L       V   P F      LY     D +T+ C   S P+ +I W R            I   G+ +     +  D G YIC     AG  + DL  K ++  K  K  I  NP   A + R++  +C I  IP      ++W   G  +   +++  ++             I N+Q +D G+Y C+ T   G AS    L   SP
Sbjct: 3352 DTLMILKA---QRFDGGLYTCVATN----SYGDSEQDFKVNVYTKPYIDETIDQTPKAVAGGE------IILKCPVLGNPTPTV-TWKRGDDAVPNDSRHTIVNNYDLKINSVTTEDAGQYSCIAVN--EAGNLTTHYAAEVIGKPTFVRKGGNLYEVIENDTITMDCGVTSRPLPSISWFRGDKPVYLYDRYSISPDGSHITINKAKLSDGGKYICRASNEAGTSDIDLILKILVPPKIDKSNIIGNP--LAIVARTIYLECPISGIP---QPDVIWTKNGMDINMTDSRVILAQNN------ETFGIENVQVTDQGRYTCTATNRGGKASHDFSLDVLSP 3666

HSP 4 Score: 57.7658 bits (138), Expect = 5.427e-8
Identity = 129/544 (23.71%), Postives = 210/544 (38.60%), Query Frame = 3

Query:  462 ENQRVTLNSTVTIQCRVQPIKNMKVYWVKSGFGLGETRSDIRSFGMVGNKVRYDIPNDLSAGNYDLQITDVNLEDEGDFYCQMNIKNNAITSQRA-QLHVLVASGPPKIIQIGNQGMGPEKLRNENSPIVVDNGDLMALRCQAERGRPGARLTWMIDNEIIEPDLSGNFNGIISGTITNISKKIVNNTKLRDSFSTLKAKVNQLLNGKS--IKCSATNR-GFEKFNFPEAKAKIEIHVAPTVTMDIVSQNLGNE---FSENDWITISCS-ALGRPDKFLWKWYINDNEVMNDNRSSYKIKATRTM-------NKAVVKCIANN--GKEGHDLRMLNVKYGPQFKDDSPPLYPANIGDDVTLTCNTDSNPMANIYW---QRESNNDIIGHGTILYRKNIQELDF--GTYICTAGVENFDLKSKKIILAKRIKPMIRE---NPDHRASLGRSVQAKC-VIDSIPIANHNQIMWLYRGRRLINDNTKYSISTEKYVDHSISILSINNIQASDFGQYNCSVTTDLGSASKVMVLSKTSPIPLILIVGG 2015
            +N  V L   +++ C +Q   + K  +V S  G    R D              IP+D     + L ITD   E+ G + C+  + N+A  ++R   L VL    PP  +         E +   N  ++ +N   + L+CQ   G P   + W ID   +  D S  F+                     +S S L+    + L GKS  I C+A N+ G    +F      I+   APT       +N G++   F E++ IT+ C  +LG    F   W +     + +N + + +  TR         ++ +  C+ANN  G+   D  ++ V+  P+ K+    L   N G+++ LTC+ + NP     W   Q +   + +               +  G Y C A         K I +  R KP         +   +L RS+  +C V D+I +     I W   G+  + +             H +S       +  D G Y C+VT + G A+K   L    P P I+  GG
Sbjct: 1650 DNLEVFLGKDISLSCDLQTESDDKTTFVWSINGSESDRPD-----------NVQIPSD----GHRLYITDAKPENNGKYMCR--VTNSAGKAERTLTLDVL---EPPVFV---------EPVFEANQKLIGNNP--IILQCQV-TGNPKPTVIWKIDGNDV--DKSWLFD---------------------ESLSLLRI---EKLTGKSAQISCTAENKAGTASRDF-----FIQNIAAPTF------KNEGDQETIFRESETITLDCPVSLG---DFQITW-MKQGLPLTENDAIFTLDNTRLTILNANRDHEDIYTCVANNTAGQVSKDFDVV-VQVLPKIKNAVVTL-EINEGEEIILTCDAEGNPTPTAKWDFNQGDLPKEAVFVNNNHTVVVNNVTKYHTGVYKCYA-TNKVGQAVKTINVHVRTKPRFESGLTESELTVNLTRSITLECDVDDAIGVG----ISWTVNGKPFLAETDGVQTLAGGRFLHIVSA------KTDDHGSYACTVTNEAGVATKTFNLFVQVP-PTIVNEGG 2106

HSP 5 Score: 54.299 bits (129), Expect = 5.608e-7
Identity = 121/543 (22.28%), Postives = 204/543 (37.57%), Query Frame = 3

Query:  462 ENQRVTLNSTVTIQCRVQPIKNMKVYWVKSGFGLG-ETRSDIRSFGMVGNKVRYDIPNDLSAGNYDLQITDVNLEDEGDFYCQMNIKNNAITSQRAQLHVLVASGPPKIIQIGNQGMGPEKLRNENSPIVVDNGDLMALRCQAERGRPGARLTWMIDNEIIEPDLSGNFNGIISGTITNISKKIVNNTKLRDSFSTLKAKVNQLLNGKSIKCSATNR-GFEKFNFPEAKAKIEIHVAPTV----TMDIVSQNLGNEFSENDWITISCSALGRPDKFLWKWYI-------NDNEVMNDNRSSYKIKATRTMNKAVVKCIANNGKEGHDLR-MLNVKYGPQFKDDSPPLYPANIGDDVTLTCNTDSNPMANIYWQRES---NNDII---------GHGTILYRKNIQELDFGTYICTAGVENFDLKSKKII-LAKRIKPMIRENPDHRASLG-------RSVQAKCVIDSIPIANHNQIMWLYRGRRLINDNTKYSISTEKYVDHSISILSINNIQASDFGQYNCSVTTDLGSASKVMVLSKTSP 1988
            +N+    +STVT+ C         + W K G  +  E  +DI             IPN    GN  L+IT +   D G + C+    +N+  S    ++V V + P    +I   G+  +    +N  +V+         C     RP A++TW+   + ++ D             T+ + + +   KLR++ S+               C ATN  G +K +F     K+ + VAP+      +  ++ N GN        T+ C A G P   +  W         ND  V  D     +I  T   ++    CIA N     DL   L V   P    +         G    L C+++S  + ++ WQ++    N D +           G  +   + ++ D G Y C   V N   +++K+   A    P I    D  +S           V+  CV+   P   H ++ WL+  + L  D+  Y ++      ++   L I   Q    G Y C    ++G A K  ++  T+P
Sbjct: 2296 KNKTAVEHSTVTLSCPATGKPEPDITWFKDGEAIHIENIADI-------------IPNGELNGN-QLKITRIKEGDAGKYTCEA---DNSAGSVEQDVNVNVITIP----KIEKDGIPSDYESQQNERVVI--------SCPV-YARPPAKITWLKAGKPLQSD---------KFVKTSANGQKLYLFKLRETDSS------------KYTCIATNEAGTDKRDF-----KVSMLVAPSFDEPNIVRRITVNSGNPS------TLHCPAKGSPSPTI-TWLKDGNAIEPNDRYVFFDAGRQLQISKTEGSDQGRYTCIATNSVGSDDLENTLEVIIPPVIDGERREAVAVIEGFSSELFCDSNSTGV-DVEWQKDGLTINQDTLRGDSFIQIPSSGKKMSFLSARKSDSGRYTCI--VRNPAGEARKLFDFAVNDPPSIS---DELSSANIQTIVPYYPVEINCVVSGSP---HPKVYWLFDDKPLEPDSAAYELT------NNGETLKIVRSQVEHAGTYTCEAQNNVGKARKDFLVRVTAP 2760

HSP 6 Score: 52.373 bits (124), Expect = 2.071e-6
Identity = 99/414 (23.91%), Postives = 160/414 (38.65%), Query Frame = 3

Query:  804 GMGPEKLRNENSPIVVDNGDLMALRCQAERGRPGARLTWMIDNEIIEPDLSGNFNGIISGTITNISKKIVNNTKLRDSFSTLKAKVNQLLNGKSIKCSATNRGFEKFNFPEAKAKIEIHVAPTVTMDIVSQNLGNEFSENDWITISCSALGRPDKFLWKWYIND---NEVMNDNRSSYKIKATRTMNKAVVKCIANNGKEGHDLRM--LNVKYGPQFKDDSPPLYPANIGDDVTLTCNTDSNPMANIYWQRES---NNDIIGHGT----ILYRKNIQELDFGTYIC-TAGVENFDLKSKKIILAKRIKPMIRENPDHRASL-GRSVQAKCVIDSIPIANHNQIMWLYRGRRLINDNTKYSISTEKYVDHSISILSINNIQASDFGQYNCSVTTDLGSASKVMVLSKTSPIPLIL 2003
            GM  + +   NS   V +G+  A+ C    G P   +TW +D   I P+ S +F      T+T  +  IV   K   S+S +              C ATN   +     E K  I I   P ++    S N+      +D  TI C   G P K +  W ++D    E + +   S  I      ++    C A N   G+D R   L V   P    ++     A   DD+ L C   + P     W  E    ++ +I H       L  +N++  + G ++C  + +   D  S  + + ++ K +I E P     + G +++  C    +P        W   G  L  D  K+S+        ++  L I     +D G YNC VT + G++     +    P P+IL
Sbjct:  997 GMDEKHVAVVNSTHDVLDGEGFAIPCVVS-GTPPPIITWYLDGRPITPN-SRDF------TVTADNTLIVR--KADKSYSGVYT------------CQATNSAGDN----EQKTTIRIMNTPMISPGQSSFNM----VVDDLFTIPCDVYGDP-KPVITWLLDDKPFTEGVVNEDGSLTIPNVNEAHRGTFTCHAQNAA-GNDTRTVTLTVHTTPTINAENQEKI-ALQNDDIVLECPAKALPPPVRLWTYEGEKIDSQLIPHTIREDGALVLQNVKLENTGVFVCQVSNLAGEDSLSYTLTVHEKPK-IISEVPGVVDVVKGFTIEIPCRATGVPEVIRT---WNKNGIDLKMDEKKFSVD-------NLGTLRIYEADKNDIGNYNCVVTNEAGTSQMTTHVDVQEP-PIIL 1365

HSP 7 Score: 51.6026 bits (122), Expect = 3.997e-6
Identity = 128/536 (23.88%), Postives = 211/536 (39.37%), Query Frame = 3

Query:  468 QRVTLNSTVTIQCRVQPIKNMKVYWVKSGFGLGETRSDIRSFGMVGNKVRYDIPNDLSAGNYDLQITDVNLEDEGDFYCQMNIKNNAITSQRA-QLHVLVASGPPKIIQIGNQGMGPEKLRNENSPIVVDNGDLMALRCQAERGRPGARLTWMIDNEIIEPDLSGNFNGIISGTITNISKKIVNNTKLRDSFSTLKAKVNQLLNGKSIKCSATN-RGFEKFNFPEAKAKIEIHVAPTVTMDIVSQNLGNEF---SENDWITISCSALGRPD-----KFLWKWYINDNEVMNDNRSSYKIKATRTMNKAVVKCIANNGKEGHDLRM--LNVKYGPQFKDDSPPLYPANIGDDVTLTCNTDSNPMANIYWQRES---NNDIIGHGTILYRK-----NIQELDFGTYICTAGVENFDLKSKK-IILAKRIKP-MIRENPDHRASLGRSVQAKCVIDSIPIANHNQIMWLYRGRRLINDNTKYSISTEKYVDHSISILSINNIQASDFGQYNCSVTTDLGS--ASKVMVLSKTS--PIPL 1997
            ++V       I+C V+     +V W+++G  + ET       G+ G  VRY     ++ G   L I +    D G + C     N A ++Q+A  L VLV+   PKII      + P             +G   +L C A RG P   ++W ++   I+   +G+  G   GT+                    KA+   L+     +C+A N  G +   FP     ++  VAP ++        GN +   SE     I C            K       ++N + +++    KI +TR  ++    C A N K G+  +   LNV   P+  +  P     + GD VTL C     P   I W +++    N  +       +K     +I     G Y C A  EN+   +++ I L   I P ++ E  +   +  ++V   C    IP      I W+      I +N KY I          + L+I N+   D G Y+C   +D G   A++ ++++K S  P P+
Sbjct: 4091 KQVIEGELAVIECLVEGYPAPQVSWLRNGNRV-ET-------GVQG--VRY-----VTDGRM-LTIIEARSLDSGIYLCSAT--NEAGSAQQAYTLEVLVS---PKIITSTPGVLTPS------------SGSKFSLPC-AVRGYPDPIISWTLNGNDIKDGENGHTIGA-DGTL-----------------HIEKAEERHLI----YECTAKNDAGADTLEFP-----VQTIVAPKISTS------GNRYINGSEGTETVIKCEIESESSEFSWSKNGVPLLPSNNLIFSEDYKLIKILSTRLSDQGEYSCTAAN-KAGNATQKTNLNVGVAPKIME-RPRTQVVHKGDQVTLWCEASGVPQPAITWYKDNELLTNTGVDETATTKKKSVIFSSISPSQAGVYTCKA--ENWVASTEEDIDLIVMIPPEVVPERMNVSTNPRQTVFLSCNATGIP---EPVISWMRDSNIAIQNNEKYQILG--------TTLAIRNVLPDDDGFYHCIAKSDAGQKIATRKLIVNKPSDRPAPI 4544

[Close]

BLAST of NEPH-2 vs. Ensembl Celegans
Match: him-4 (High Incidence of Males (Increased X chromosome loss) [Source:UniProtKB/TrEMBL;Acc:A4UVK0])

HSP 1 Score: 75.0998 bits (183), Expect = 2.804e-13
Identity = 109/514 (21.21%), Postives = 185/514 (35.99%), Query Frame = 3

Query:  489 TVTIQCRVQPIKNMKVYWVKSGFGLGETRSDIRSFGMVGNKVRYDIPNDLSAGNYDLQITDVNLEDEGDFYCQMNIKNNAITSQRAQLHVLVASGPPKIIQIGNQGMGPEKLRNENSPIVVDNGDLMALRCQAERGRPGAR----LTWMIDNEIIEPDLSGNFNGIISGTITNISKKIVNNTKLRDSFSTLKAKVNQLLNGKSIKCSATNRGFEKFNFPEAKAKIEIHVAPTVTMDIVSQNLGNEFSENDWITISCSALGRPDKFLWKWYINDNEVMNDNR-------SSYKIKATRTMNKAVVKCIANNGKEGHDLRMLNVKYGP---QFKDDSPPLYPANIGDDVTLTCNTDSNPMANIYWQRESN--------NDIIGHGTILYRKNIQELDFGTYIC----TAGVENFDLKSKKIILAKRIKPMIRENPDHRASLGRSVQAKCVIDSIPIANHNQIMWLYRGRRLINDNTKYSISTEKYVDHSISILSINNIQASDFGQYNCSVTTDLGS 1952
            T+ ++C +  I    V W K+G  +  T S +                 L+  N    I +V + D+G + C    +     S    L VL    PP+    G Q            P +   GD + L C  +     A     ++W  D+  ++ DL+ N +    G    IS+  + N  L                     C A NR  E       + K+EI   P +  DI   ++  + + N    + C+  G P   + KW  N  EV +D            +I  T + +     C+A N     +L M+   + P     K D+P      +G+ +TL CN   NP   + W +  +          I   G  L   ++++ D G Y C     AG     +    ++  +  +  I  +P  R    +S+  +C+    P+    Q+ W   G  L +     +++++       + + INN+  SD G Y C      GS
Sbjct: 3591 TIYLECPISGIPQPDVIWTKNGMDINMTDSRVI----------------LAQNNETFGIENVQVTDQGRYTCTATNRGGK-ASHDFSLDVL---SPPEFDIHGTQ------------PTIKREGDTITLTCPIKLAEDIADQVMDVSWTKDSRALDGDLTDNVDISDDGRKLTISQASLENAGL-------------------YTCIALNRAGEA----SLEFKVEILSPPVI--DISRNDVQPQVAVNQPTIMRCAVTGHPFPSI-KWLKNGKEVTDDENIRIVEQGQVLQILRTDSDHAGKWSCVAENDAGVKELEMVLDVFTPPVVSVKSDNPI---KALGETITLFCNASGNPYPQLKWAKGGSLIFDSPDGARISLKGARLDIPHLKKTDVGDYTCQALNAAGTSEASVSVDVLVPPEINRDGIDMSP--RLPAQQSLTLQCLAQGKPVP---QMRWTLNGTALTHSTPGITVASDS------TFIQINNVSLSDKGVYTCYAENVAGS 4032

HSP 2 Score: 71.633 bits (174), Expect = 3.296e-12
Identity = 116/508 (22.83%), Postives = 191/508 (37.60%), Query Frame = 3

Query:  471 RVTLNSTVTIQCRVQPIKNMKVYWVKSGFGLGETRSDIRSFGMVGNKVRYDIPNDLSAGNYDLQITDVNLEDEGDFYCQMNIKNNAITSQRAQLHVLVA-SGPPKIIQIGNQGMGPEKLRNENSPIVVDNGDLMALRCQAERGRPGARLTWMIDNEIIEPDLSGNFNGIISGTITNISKKIVNNTKLRDSFSTLKAKVNQLLNGKSIKCSATNRGFEKFNFPEAKAKIEIHVAPTVTMD--IVSQNLGNEFSENDWITISCSALGRPDKFLWKWYINDNEVMNDNRSSYKIKATRTMNKAVVKCIANN--GKEGHDLRMLNVKYGPQFKDDSPPLYPANI--GDDVTLTCNTDSNPMANIYWQRES-----NNDIIG-HGTILYRKNIQELDFGTYICTAGVENFDLKSKKIILAKRIKPMIRENPDH--RASLGRSVQAKCVIDSIPIANHNQIMWLYRGRRLINDNTKYSISTEKYVDHSISILSINNIQASDFGQYNCSVTTDLG 1949
             +  ++T+ I CR + I   ++ W   G  + E         M G  V Y        G+  L+I ++    EG + C    K     + RA+    V  S PP+++      M  E +R       V  G    +RC+   G P   + W+ D E    DL                  +  +TKL    S L  +   L +G +  C ATN+  E     +    +E+ V P +  +  ++    GN +       + C   GRP  ++  W  N  E+   N   +   ATR  ++    CIA+N  G    D  +++V   P F+         NI  G+   + C  D +P   I W +       +N I+   G  L     Q  D G Y C A   ++    +   +    KP I E  D   +A  G  +  KC +    + N    +   RG   + ++++++I            L IN++   D GQY+C    + G
Sbjct: 3046 EIVADTTLEIPCRTEGIPPPEISWFLDGKPILE---------MPG--VTY------KQGDLSLRIDNIKPNQEGRYTCVAENK-----AGRAEQDTYVEISEPPRVV------MASEVMR-------VVEGRQTTIRCEV-FGNPEPVVNWLKDGEPYTSDL------------------LQFSTKL----SYLHLRETTLADGGTYTCIATNKAGES----QTTTDVEVLVPPRIEDEERVLQGKEGNTY------MVHCQVTGRPVPYV-TWKRNGKEIEQFNPVLHIRNATRA-DEGKYSCIASNEAGTAVADF-LIDVFTKPTFETHETTF---NIVEGESAKIECKIDGHPKPTISWLKGGRPFNMDNIILSPRGDTLMILKAQRFDGGLYTCVA-TNSYGDSEQDFKVNVYTKPYIDETIDQTPKAVAGGEIILKCPV----LGNPTPTVTWKRGDDAVPNDSRHTIVNNYD-------LKINSVTTEDAGQYSCIAVNEAG 3467

HSP 3 Score: 71.2478 bits (173), Expect = 3.805e-12
Identity = 89/342 (26.02%), Postives = 133/342 (38.89%), Query Frame = 3

Query: 1032 DSFSTLKAKVNQLLNGKSIKCSATNRGFEKFNFPEAKAKIEIHVAPTV--TMDIVSQNL-GNEFSENDWITISCSALGRPDKFLWKWYINDNEVMNDNRSS------YKIKATRTMNKAVVKCIANNGKEGHDLR---MLNVKYGPQFKDDSPPLYPANIGDDVTLTCNTDSNPMANIYWQRESN-------NDIIGHGTILYRKNIQELDFGTYIC----TAGVENFDLKSKKIILAKRIKPMIRENPDHRASLGRSVQAKCVIDSIPIANHNQIMWLYRGRRLINDNTKYSISTEKYVDHSISILSINNIQASDFGQYNCSVTTDLGSASKVMVLSKTSP 1988
            D+   LKA   Q  +G    C ATN     +   E   K+ ++  P +  T+D   + + G E      I + C  LG P   +  W   D+ V ND+R +       KI +  T +     CIA N  E  +L       V   P F      LY     D +T+ C   S P+ +I W R            I   G+ +     +  D G YIC     AG  + DL  K ++  K  K  I  NP   A + R++  +C I  IP      ++W   G  +   +++  ++             I N+Q +D G+Y C+ T   G AS    L   SP
Sbjct: 3352 DTLMILKA---QRFDGGLYTCVATN----SYGDSEQDFKVNVYTKPYIDETIDQTPKAVAGGE------IILKCPVLGNPTPTV-TWKRGDDAVPNDSRHTIVNNYDLKINSVTTEDAGQYSCIAVN--EAGNLTTHYAAEVIGKPTFVRKGGNLYEVIENDTITMDCGVTSRPLPSISWFRGDKPVYLYDRYSISPDGSHITINKAKLSDGGKYICRASNEAGTSDIDLILKILVPPKIDKSNIIGNP--LAIVARTIYLECPISGIP---QPDVIWTKNGMDINMTDSRVILAQNN------ETFGIENVQVTDQGRYTCTATNRGGKASHDFSLDVLSP 3666

HSP 4 Score: 57.7658 bits (138), Expect = 5.426e-8
Identity = 129/544 (23.71%), Postives = 210/544 (38.60%), Query Frame = 3

Query:  462 ENQRVTLNSTVTIQCRVQPIKNMKVYWVKSGFGLGETRSDIRSFGMVGNKVRYDIPNDLSAGNYDLQITDVNLEDEGDFYCQMNIKNNAITSQRA-QLHVLVASGPPKIIQIGNQGMGPEKLRNENSPIVVDNGDLMALRCQAERGRPGARLTWMIDNEIIEPDLSGNFNGIISGTITNISKKIVNNTKLRDSFSTLKAKVNQLLNGKS--IKCSATNR-GFEKFNFPEAKAKIEIHVAPTVTMDIVSQNLGNE---FSENDWITISCS-ALGRPDKFLWKWYINDNEVMNDNRSSYKIKATRTM-------NKAVVKCIANN--GKEGHDLRMLNVKYGPQFKDDSPPLYPANIGDDVTLTCNTDSNPMANIYW---QRESNNDIIGHGTILYRKNIQELDF--GTYICTAGVENFDLKSKKIILAKRIKPMIRE---NPDHRASLGRSVQAKC-VIDSIPIANHNQIMWLYRGRRLINDNTKYSISTEKYVDHSISILSINNIQASDFGQYNCSVTTDLGSASKVMVLSKTSPIPLILIVGG 2015
            +N  V L   +++ C +Q   + K  +V S  G    R D              IP+D     + L ITD   E+ G + C+  + N+A  ++R   L VL    PP  +         E +   N  ++ +N   + L+CQ   G P   + W ID   +  D S  F+                     +S S L+    + L GKS  I C+A N+ G    +F      I+   APT       +N G++   F E++ IT+ C  +LG    F   W +     + +N + + +  TR         ++ +  C+ANN  G+   D  ++ V+  P+ K+    L   N G+++ LTC+ + NP     W   Q +   + +               +  G Y C A         K I +  R KP         +   +L RS+  +C V D+I +     I W   G+  + +             H +S       +  D G Y C+VT + G A+K   L    P P I+  GG
Sbjct: 1650 DNLEVFLGKDISLSCDLQTESDDKTTFVWSINGSESDRPD-----------NVQIPSD----GHRLYITDAKPENNGKYMCR--VTNSAGKAERTLTLDVL---EPPVFV---------EPVFEANQKLIGNNP--IILQCQV-TGNPKPTVIWKIDGNDV--DKSWLFD---------------------ESLSLLRI---EKLTGKSAQISCTAENKAGTASRDF-----FIQNIAAPTF------KNEGDQETIFRESETITLDCPVSLG---DFQITW-MKQGLPLTENDAIFTLDNTRLTILNANRDHEDIYTCVANNTAGQVSKDFDVV-VQVLPKIKNAVVTL-EINEGEEIILTCDAEGNPTPTAKWDFNQGDLPKEAVFVNNNHTVVVNNVTKYHTGVYKCYA-TNKVGQAVKTINVHVRTKPRFESGLTESELTVNLTRSITLECDVDDAIGVG----ISWTVNGKPFLAETDGVQTLAGGRFLHIVSA------KTDDHGSYACTVTNEAGVATKTFNLFVQVP-PTIVNEGG 2106

HSP 5 Score: 54.299 bits (129), Expect = 5.947e-7
Identity = 121/543 (22.28%), Postives = 204/543 (37.57%), Query Frame = 3

Query:  462 ENQRVTLNSTVTIQCRVQPIKNMKVYWVKSGFGLG-ETRSDIRSFGMVGNKVRYDIPNDLSAGNYDLQITDVNLEDEGDFYCQMNIKNNAITSQRAQLHVLVASGPPKIIQIGNQGMGPEKLRNENSPIVVDNGDLMALRCQAERGRPGARLTWMIDNEIIEPDLSGNFNGIISGTITNISKKIVNNTKLRDSFSTLKAKVNQLLNGKSIKCSATNR-GFEKFNFPEAKAKIEIHVAPTV----TMDIVSQNLGNEFSENDWITISCSALGRPDKFLWKWYI-------NDNEVMNDNRSSYKIKATRTMNKAVVKCIANNGKEGHDLR-MLNVKYGPQFKDDSPPLYPANIGDDVTLTCNTDSNPMANIYWQRES---NNDII---------GHGTILYRKNIQELDFGTYICTAGVENFDLKSKKII-LAKRIKPMIRENPDHRASLG-------RSVQAKCVIDSIPIANHNQIMWLYRGRRLINDNTKYSISTEKYVDHSISILSINNIQASDFGQYNCSVTTDLGSASKVMVLSKTSP 1988
            +N+    +STVT+ C         + W K G  +  E  +DI             IPN    GN  L+IT +   D G + C+    +N+  S    ++V V + P    +I   G+  +    +N  +V+         C     RP A++TW+   + ++ D             T+ + + +   KLR++ S+               C ATN  G +K +F     K+ + VAP+      +  ++ N GN        T+ C A G P   +  W         ND  V  D     +I  T   ++    CIA N     DL   L V   P    +         G    L C+++S  + ++ WQ++    N D +           G  +   + ++ D G Y C   V N   +++K+   A    P I    D  +S           V+  CV+   P   H ++ WL+  + L  D+  Y ++      ++   L I   Q    G Y C    ++G A K  ++  T+P
Sbjct: 2296 KNKTAVEHSTVTLSCPATGKPEPDITWFKDGEAIHIENIADI-------------IPNGELNGN-QLKITRIKEGDAGKYTCEA---DNSAGSVEQDVNVNVITIP----KIEKDGIPSDYESQQNERVVI--------SCPV-YARPPAKITWLKAGKPLQSD---------KFVKTSANGQKLYLFKLRETDSS------------KYTCIATNEAGTDKRDF-----KVSMLVAPSFDEPNIVRRITVNSGNPS------TLHCPAKGSPSPTI-TWLKDGNAIEPNDRYVFFDAGRQLQISKTEGSDQGRYTCIATNSVGSDDLENTLEVIIPPVIDGERREAVAVIEGFSSELFCDSNSTGV-DVEWQKDGLTINQDTLRGDSFIQIPSSGKKMSFLSARKSDSGRYTCI--VRNPAGEARKLFDFAVNDPPSIS---DELSSANIQTIVPYYPVEINCVVSGSP---HPKVYWLFDDKPLEPDSAAYELT------NNGETLKIVRSQVEHAGTYTCEAQNNVGKARKDFLVRVTAP 2760

HSP 6 Score: 52.373 bits (124), Expect = 2.106e-6
Identity = 99/414 (23.91%), Postives = 160/414 (38.65%), Query Frame = 3

Query:  804 GMGPEKLRNENSPIVVDNGDLMALRCQAERGRPGARLTWMIDNEIIEPDLSGNFNGIISGTITNISKKIVNNTKLRDSFSTLKAKVNQLLNGKSIKCSATNRGFEKFNFPEAKAKIEIHVAPTVTMDIVSQNLGNEFSENDWITISCSALGRPDKFLWKWYIND---NEVMNDNRSSYKIKATRTMNKAVVKCIANNGKEGHDLRM--LNVKYGPQFKDDSPPLYPANIGDDVTLTCNTDSNPMANIYWQRES---NNDIIGHGT----ILYRKNIQELDFGTYIC-TAGVENFDLKSKKIILAKRIKPMIRENPDHRASL-GRSVQAKCVIDSIPIANHNQIMWLYRGRRLINDNTKYSISTEKYVDHSISILSINNIQASDFGQYNCSVTTDLGSASKVMVLSKTSPIPLIL 2003
            GM  + +   NS   V +G+  A+ C    G P   +TW +D   I P+ S +F      T+T  +  IV   K   S+S +              C ATN   +     E K  I I   P ++    S N+      +D  TI C   G P K +  W ++D    E + +   S  I      ++    C A N   G+D R   L V   P    ++     A   DD+ L C   + P     W  E    ++ +I H       L  +N++  + G ++C  + +   D  S  + + ++ K +I E P     + G +++  C    +P        W   G  L  D  K+S+        ++  L I     +D G YNC VT + G++     +    P P+IL
Sbjct:  997 GMDEKHVAVVNSTHDVLDGEGFAIPCVVS-GTPPPIITWYLDGRPITPN-SRDF------TVTADNTLIVR--KADKSYSGVYT------------CQATNSAGDN----EQKTTIRIMNTPMISPGQSSFNM----VVDDLFTIPCDVYGDP-KPVITWLLDDKPFTEGVVNEDGSLTIPNVNEAHRGTFTCHAQNAA-GNDTRTVTLTVHTTPTINAENQEKI-ALQNDDIVLECPAKALPPPVRLWTYEGEKIDSQLIPHTIREDGALVLQNVKLENTGVFVCQVSNLAGEDSLSYTLTVHEKPK-IISEVPGVVDVVKGFTIEIPCRATGVPEVIRT---WNKNGIDLKMDEKKFSVD-------NLGTLRIYEADKNDIGNYNCVVTNEAGTSQMTTHVDVQEP-PIIL 1365

HSP 7 Score: 52.373 bits (124), Expect = 2.178e-6
Identity = 107/502 (21.31%), Postives = 180/502 (35.86%), Query Frame = 3

Query:  585 RSFGMVGNKVRYDIPNDLSAGNYDLQITDVNLEDEGDFYC-QMNIKNNAITSQRAQLHVLVASGPPKIIQIGNQGMGPEKLRNENSPIVVDNGDLMALRCQAERGRPGARLTW--------MIDNEIIEPDLSGNFNGIISGTITNISKKIVNNTKLRDSFSTLKAKVNQLLNGKSIKCSATNRGFEKFNFPEAKAKIEIHVAPTVTMDIVSQNLGNEFSENDWITISCSALGRPDKFLWKWYINDNE-----VMNDNRSSYKIKATRTMNKAVVKCIANN--GKEGHDLRMLNVKYGPQFKDDSPPLYPANIGDDVTLTCNTD-----SNPMANIYWQRES---------NNDIIGHGTILYRKNIQELDFGTYICTA----GVENFDLKSKKIILAKRIKPMIRENPDHRASLGRSVQAKCVIDSIPIANHNQIMWLYRGRRLINDNTKYSISTEKYVDHSISILSINNIQASDFGQYNCSVTTDLGSASKVMVLSKTSP 1988
            R    V N  R+ I N     NYDL+I  V  ED G + C  +N   N  T   A++      G P  ++ G            N   V++N D + + C     RP   ++W        + D   I PD S                  +N  KL D              GK I C A+N         +    ++I V P +    +  N     +   ++    S + +PD    K  ++ N      ++  N  ++ I+  +  ++    C A N  GK  HD   L+V   P+F            GD +TLTC        ++ + ++ W ++S         N DI   G  L        + G Y C A    G  + + K +  IL+  +  + R +   + ++ +    +C +   P  +   I WL  G+ + +D     +   +       +L I    +   G+++C    D G     MVL   +P
Sbjct: 3426 RGDDAVPNDSRHTIVN-----NYDLKINSVTTEDAGQYSCIAVNEAGNLTTHYAAEV-----IGKPTFVRKGG-----------NLYEVIEN-DTITMDCGV-TSRPLPSISWFRGDKPVYLYDRYSISPDGS---------------HITINKAKLSDG-------------GKYI-CRASNEA----GTSDIDLILKILVPPKIDKSNIIGNPLAIVARTIYLECPISGIPQPDVIWTKNGMDINMTDSRVILAQNNETFGIENVQVTDQGRYTCTATNRGGKASHDFS-LDVLSPPEFDIHGTQPTIKREGDTITLTCPIKLAEDIADQVMDVSWTKDSRALDGDLTDNVDISDDGRKLTISQASLENAGLYTCIALNRAGEASLEFKVE--ILSPPVIDISRNDVQPQVAVNQPTIMRCAVTGHPFPS---IKWLKNGKEVTDDENIRIVEQGQ-------VLQILRTDSDHAGKWSCVAENDAGVKELEMVLDVFTP 3858

HSP 8 Score: 51.6026 bits (122), Expect = 4.239e-6
Identity = 128/536 (23.88%), Postives = 211/536 (39.37%), Query Frame = 3

Query:  468 QRVTLNSTVTIQCRVQPIKNMKVYWVKSGFGLGETRSDIRSFGMVGNKVRYDIPNDLSAGNYDLQITDVNLEDEGDFYCQMNIKNNAITSQRA-QLHVLVASGPPKIIQIGNQGMGPEKLRNENSPIVVDNGDLMALRCQAERGRPGARLTWMIDNEIIEPDLSGNFNGIISGTITNISKKIVNNTKLRDSFSTLKAKVNQLLNGKSIKCSATN-RGFEKFNFPEAKAKIEIHVAPTVTMDIVSQNLGNEF---SENDWITISCSALGRPD-----KFLWKWYINDNEVMNDNRSSYKIKATRTMNKAVVKCIANNGKEGHDLRM--LNVKYGPQFKDDSPPLYPANIGDDVTLTCNTDSNPMANIYWQRES---NNDIIGHGTILYRK-----NIQELDFGTYICTAGVENFDLKSKK-IILAKRIKP-MIRENPDHRASLGRSVQAKCVIDSIPIANHNQIMWLYRGRRLINDNTKYSISTEKYVDHSISILSINNIQASDFGQYNCSVTTDLGS--ASKVMVLSKTS--PIPL 1997
            ++V       I+C V+     +V W+++G  + ET       G+ G  VRY     ++ G   L I +    D G + C     N A ++Q+A  L VLV+   PKII      + P             +G   +L C A RG P   ++W ++   I+   +G+  G   GT+                    KA+   L+     +C+A N  G +   FP     ++  VAP ++        GN +   SE     I C            K       ++N + +++    KI +TR  ++    C A N K G+  +   LNV   P+  +  P     + GD VTL C     P   I W +++    N  +       +K     +I     G Y C A  EN+   +++ I L   I P ++ E  +   +  ++V   C    IP      I W+      I +N KY I          + L+I N+   D G Y+C   +D G   A++ ++++K S  P P+
Sbjct: 4053 KQVIEGELAVIECLVEGYPAPQVSWLRNGNRV-ET-------GVQG--VRY-----VTDGRM-LTIIEARSLDSGIYLCSAT--NEAGSAQQAYTLEVLVS---PKIITSTPGVLTPS------------SGSKFSLPC-AVRGYPDPIISWTLNGNDIKDGENGHTIGA-DGTL-----------------HIEKAEERHLI----YECTAKNDAGADTLEFP-----VQTIVAPKISTS------GNRYINGSEGTETVIKCEIESESSEFSWSKNGVPLLPSNNLIFSEDYKLIKILSTRLSDQGEYSCTAAN-KAGNATQKTNLNVGVAPKIME-RPRTQVVHKGDQVTLWCEASGVPQPAITWYKDNELLTNTGVDETATTKKKSVIFSSISPSQAGVYTCKA--ENWVASTEEDIDLIVMIPPEVVPERMNVSTNPRQTVFLSCNATGIP---EPVISWMRDSNIAIQNNEKYQILG--------TTLAIRNVLPDDDGFYHCIAKSDAGQKIATRKLIVNKPSDRPAPI 4506

[Close]

BLAST of NEPH-2 vs. Ensembl Celegans
Match: him-4 (High Incidence of Males (Increased X chromosome loss) [Source:UniProtKB/TrEMBL;Acc:A4UVK0])

HSP 1 Score: 74.7146 bits (182), Expect = 3.377e-13
Identity = 109/514 (21.21%), Postives = 185/514 (35.99%), Query Frame = 3

Query:  489 TVTIQCRVQPIKNMKVYWVKSGFGLGETRSDIRSFGMVGNKVRYDIPNDLSAGNYDLQITDVNLEDEGDFYCQMNIKNNAITSQRAQLHVLVASGPPKIIQIGNQGMGPEKLRNENSPIVVDNGDLMALRCQAERGRPGAR----LTWMIDNEIIEPDLSGNFNGIISGTITNISKKIVNNTKLRDSFSTLKAKVNQLLNGKSIKCSATNRGFEKFNFPEAKAKIEIHVAPTVTMDIVSQNLGNEFSENDWITISCSALGRPDKFLWKWYINDNEVMNDNR-------SSYKIKATRTMNKAVVKCIANNGKEGHDLRMLNVKYGP---QFKDDSPPLYPANIGDDVTLTCNTDSNPMANIYWQRESN--------NDIIGHGTILYRKNIQELDFGTYIC----TAGVENFDLKSKKIILAKRIKPMIRENPDHRASLGRSVQAKCVIDSIPIANHNQIMWLYRGRRLINDNTKYSISTEKYVDHSISILSINNIQASDFGQYNCSVTTDLGS 1952
            T+ ++C +  I    V W K+G  +  T S +                 L+  N    I +V + D+G + C    +     S    L VL    PP+    G Q            P +   GD + L C  +     A     ++W  D+  ++ DL+ N +    G    IS+  + N  L                     C A NR  E       + K+EI   P +  DI   ++  + + N    + C+  G P   + KW  N  EV +D            +I  T + +     C+A N     +L M+   + P     K D+P      +G+ +TL CN   NP   + W +  +          I   G  L   ++++ D G Y C     AG     +    ++  +  +  I  +P  R    +S+  +C+    P+    Q+ W   G  L +     +++++       + + INN+  SD G Y C      GS
Sbjct: 3591 TIYLECPISGIPQPDVIWTKNGMDINMTDSRVI----------------LAQNNETFGIENVQVTDQGRYTCTATNRGGK-ASHDFSLDVL---SPPEFDIHGTQ------------PTIKREGDTITLTCPIKLAEDIADQVMDVSWTKDSRALDGDLTDNVDISDDGRKLTISQASLENAGL-------------------YTCIALNRAGEA----SLEFKVEILSPPVI--DISRNDVQPQVAVNQPTIMRCAVTGHPFPSI-KWLKNGKEVTDDENIRIVEQGQVLQILRTDSDHAGKWSCVAENDAGVKELEMVLDVFTPPVVSVKSDNPI---KALGETITLFCNASGNPYPQLKWAKGGSLIFDSPDGARISLKGARLDIPHLKKTDVGDYTCQALNAAGTSEASVSVDVLVPPEINRDGIDMSP--RLPAQQSLTLQCLAQGKPVP---QMRWTLNGTALTHSTPGITVASDS------TFIQINNVSLSDKGVYTCYAENVAGS 4032

HSP 2 Score: 71.633 bits (174), Expect = 3.469e-12
Identity = 116/508 (22.83%), Postives = 191/508 (37.60%), Query Frame = 3

Query:  471 RVTLNSTVTIQCRVQPIKNMKVYWVKSGFGLGETRSDIRSFGMVGNKVRYDIPNDLSAGNYDLQITDVNLEDEGDFYCQMNIKNNAITSQRAQLHVLVA-SGPPKIIQIGNQGMGPEKLRNENSPIVVDNGDLMALRCQAERGRPGARLTWMIDNEIIEPDLSGNFNGIISGTITNISKKIVNNTKLRDSFSTLKAKVNQLLNGKSIKCSATNRGFEKFNFPEAKAKIEIHVAPTVTMD--IVSQNLGNEFSENDWITISCSALGRPDKFLWKWYINDNEVMNDNRSSYKIKATRTMNKAVVKCIANN--GKEGHDLRMLNVKYGPQFKDDSPPLYPANI--GDDVTLTCNTDSNPMANIYWQRES-----NNDIIG-HGTILYRKNIQELDFGTYICTAGVENFDLKSKKIILAKRIKPMIRENPDH--RASLGRSVQAKCVIDSIPIANHNQIMWLYRGRRLINDNTKYSISTEKYVDHSISILSINNIQASDFGQYNCSVTTDLG 1949
             +  ++T+ I CR + I   ++ W   G  + E         M G  V Y        G+  L+I ++    EG + C    K     + RA+    V  S PP+++      M  E +R       V  G    +RC+   G P   + W+ D E    DL                  +  +TKL    S L  +   L +G +  C ATN+  E     +    +E+ V P +  +  ++    GN +       + C   GRP  ++  W  N  E+   N   +   ATR  ++    CIA+N  G    D  +++V   P F+         NI  G+   + C  D +P   I W +       +N I+   G  L     Q  D G Y C A   ++    +   +    KP I E  D   +A  G  +  KC +    + N    +   RG   + ++++++I            L IN++   D GQY+C    + G
Sbjct: 3046 EIVADTTLEIPCRTEGIPPPEISWFLDGKPILE---------MPG--VTY------KQGDLSLRIDNIKPNQEGRYTCVAENK-----AGRAEQDTYVEISEPPRVV------MASEVMR-------VVEGRQTTIRCEV-FGNPEPVVNWLKDGEPYTSDL------------------LQFSTKL----SYLHLRETTLADGGTYTCIATNKAGES----QTTTDVEVLVPPRIEDEERVLQGKEGNTY------MVHCQVTGRPVPYV-TWKRNGKEIEQFNPVLHIRNATRA-DEGKYSCIASNEAGTAVADF-LIDVFTKPTFETHETTF---NIVEGESAKIECKIDGHPKPTISWLKGGRPFNMDNIILSPRGDTLMILKAQRFDGGLYTCVA-TNSYGDSEQDFKVNVYTKPYIDETIDQTPKAVAGGEIILKCPV----LGNPTPTVTWKRGDDAVPNDSRHTIVNNYD-------LKINSVTTEDAGQYSCIAVNEAG 3467

HSP 3 Score: 71.2478 bits (173), Expect = 4.176e-12
Identity = 89/342 (26.02%), Postives = 133/342 (38.89%), Query Frame = 3

Query: 1032 DSFSTLKAKVNQLLNGKSIKCSATNRGFEKFNFPEAKAKIEIHVAPTV--TMDIVSQNL-GNEFSENDWITISCSALGRPDKFLWKWYINDNEVMNDNRSS------YKIKATRTMNKAVVKCIANNGKEGHDLRM---LNVKYGPQFKDDSPPLYPANIGDDVTLTCNTDSNPMANIYWQRESN-------NDIIGHGTILYRKNIQELDFGTYIC----TAGVENFDLKSKKIILAKRIKPMIRENPDHRASLGRSVQAKCVIDSIPIANHNQIMWLYRGRRLINDNTKYSISTEKYVDHSISILSINNIQASDFGQYNCSVTTDLGSASKVMVLSKTSP 1988
            D+   LKA   Q  +G    C ATN     +   E   K+ ++  P +  T+D   + + G E      I + C  LG P   +  W   D+ V ND+R +       KI +  T +     CIA N  E  +L       V   P F      LY     D +T+ C   S P+ +I W R            I   G+ +     +  D G YIC     AG  + DL  K ++  K  K  I  NP   A + R++  +C I  IP      ++W   G  +   +++  ++             I N+Q +D G+Y C+ T   G AS    L   SP
Sbjct: 3352 DTLMILKA---QRFDGGLYTCVATN----SYGDSEQDFKVNVYTKPYIDETIDQTPKAVAGGE------IILKCPVLGNPTPTV-TWKRGDDAVPNDSRHTIVNNYDLKINSVTTEDAGQYSCIAVN--EAGNLTTHYAAEVIGKPTFVRKGGNLYEVIENDTITMDCGVTSRPLPSISWFRGDKPVYLYDRYSISPDGSHITINKAKLSDGGKYICRASNEAGTSDIDLILKILVPPKIDKSNIIGNP--LAIVARTIYLECPISGIP---QPDVIWTKNGMDINMTDSRVILAQNN------ETFGIENVQVTDQGRYTCTATNRGGKASHDFSLDVLSP 3666

HSP 4 Score: 57.3806 bits (137), Expect = 6.369e-8
Identity = 129/544 (23.71%), Postives = 210/544 (38.60%), Query Frame = 3

Query:  462 ENQRVTLNSTVTIQCRVQPIKNMKVYWVKSGFGLGETRSDIRSFGMVGNKVRYDIPNDLSAGNYDLQITDVNLEDEGDFYCQMNIKNNAITSQRA-QLHVLVASGPPKIIQIGNQGMGPEKLRNENSPIVVDNGDLMALRCQAERGRPGARLTWMIDNEIIEPDLSGNFNGIISGTITNISKKIVNNTKLRDSFSTLKAKVNQLLNGKS--IKCSATNR-GFEKFNFPEAKAKIEIHVAPTVTMDIVSQNLGNE---FSENDWITISCS-ALGRPDKFLWKWYINDNEVMNDNRSSYKIKATRTM-------NKAVVKCIANN--GKEGHDLRMLNVKYGPQFKDDSPPLYPANIGDDVTLTCNTDSNPMANIYW---QRESNNDIIGHGTILYRKNIQELDF--GTYICTAGVENFDLKSKKIILAKRIKPMIRE---NPDHRASLGRSVQAKC-VIDSIPIANHNQIMWLYRGRRLINDNTKYSISTEKYVDHSISILSINNIQASDFGQYNCSVTTDLGSASKVMVLSKTSPIPLILIVGG 2015
            +N  V L   +++ C +Q   + K  +V S  G    R D              IP+D     + L ITD   E+ G + C+  + N+A  ++R   L VL    PP  +         E +   N  ++ +N   + L+CQ   G P   + W ID   +  D S  F+                     +S S L+    + L GKS  I C+A N+ G    +F      I+   APT       +N G++   F E++ IT+ C  +LG    F   W +     + +N + + +  TR         ++ +  C+ANN  G+   D  ++ V+  P+ K+    L   N G+++ LTC+ + NP     W   Q +   + +               +  G Y C A         K I +  R KP         +   +L RS+  +C V D+I +     I W   G+  + +             H +S       +  D G Y C+VT + G A+K   L    P P I+  GG
Sbjct: 1650 DNLEVFLGKDISLSCDLQTESDDKTTFVWSINGSESDRPD-----------NVQIPSD----GHRLYITDAKPENNGKYMCR--VTNSAGKAERTLTLDVL---EPPVFV---------EPVFEANQKLIGNNP--IILQCQV-TGNPKPTVIWKIDGNDV--DKSWLFD---------------------ESLSLLRI---EKLTGKSAQISCTAENKAGTASRDF-----FIQNIAAPTF------KNEGDQETIFRESETITLDCPVSLG---DFQITW-MKQGLPLTENDAIFTLDNTRLTILNANRDHEDIYTCVANNTAGQVSKDFDVV-VQVLPKIKNAVVTL-EINEGEEIILTCDAEGNPTPTAKWDFNQGDLPKEAVFVNNNHTVVVNNVTKYHTGVYKCYA-TNKVGQAVKTINVHVRTKPRFESGLTESELTVNLTRSITLECDVDDAIGVG----ISWTVNGKPFLAETDGVQTLAGGRFLHIVSA------KTDDHGSYACTVTNEAGVATKTFNLFVQVP-PTIVNEGG 2106

HSP 5 Score: 53.9138 bits (128), Expect = 7.281e-7
Identity = 121/543 (22.28%), Postives = 204/543 (37.57%), Query Frame = 3

Query:  462 ENQRVTLNSTVTIQCRVQPIKNMKVYWVKSGFGLG-ETRSDIRSFGMVGNKVRYDIPNDLSAGNYDLQITDVNLEDEGDFYCQMNIKNNAITSQRAQLHVLVASGPPKIIQIGNQGMGPEKLRNENSPIVVDNGDLMALRCQAERGRPGARLTWMIDNEIIEPDLSGNFNGIISGTITNISKKIVNNTKLRDSFSTLKAKVNQLLNGKSIKCSATNR-GFEKFNFPEAKAKIEIHVAPTV----TMDIVSQNLGNEFSENDWITISCSALGRPDKFLWKWYI-------NDNEVMNDNRSSYKIKATRTMNKAVVKCIANNGKEGHDLR-MLNVKYGPQFKDDSPPLYPANIGDDVTLTCNTDSNPMANIYWQRES---NNDII---------GHGTILYRKNIQELDFGTYICTAGVENFDLKSKKII-LAKRIKPMIRENPDHRASLG-------RSVQAKCVIDSIPIANHNQIMWLYRGRRLINDNTKYSISTEKYVDHSISILSINNIQASDFGQYNCSVTTDLGSASKVMVLSKTSP 1988
            +N+    +STVT+ C         + W K G  +  E  +DI             IPN    GN  L+IT +   D G + C+    +N+  S    ++V V + P    +I   G+  +    +N  +V+         C     RP A++TW+   + ++ D             T+ + + +   KLR++ S+               C ATN  G +K +F     K+ + VAP+      +  ++ N GN        T+ C A G P   +  W         ND  V  D     +I  T   ++    CIA N     DL   L V   P    +         G    L C+++S  + ++ WQ++    N D +           G  +   + ++ D G Y C   V N   +++K+   A    P I    D  +S           V+  CV+   P   H ++ WL+  + L  D+  Y ++      ++   L I   Q    G Y C    ++G A K  ++  T+P
Sbjct: 2296 KNKTAVEHSTVTLSCPATGKPEPDITWFKDGEAIHIENIADI-------------IPNGELNGN-QLKITRIKEGDAGKYTCEA---DNSAGSVEQDVNVNVITIP----KIEKDGIPSDYESQQNERVVI--------SCPV-YARPPAKITWLKAGKPLQSD---------KFVKTSANGQKLYLFKLRETDSS------------KYTCIATNEAGTDKRDF-----KVSMLVAPSFDEPNIVRRITVNSGNPS------TLHCPAKGSPSPTI-TWLKDGNAIEPNDRYVFFDAGRQLQISKTEGSDQGRYTCIATNSVGSDDLENTLEVIIPPVIDGERREAVAVIEGFSSELFCDSNSTGV-DVEWQKDGLTINQDTLRGDSFIQIPSSGKKMSFLSARKSDSGRYTCI--VRNPAGEARKLFDFAVNDPPSIS---DELSSANIQTIVPYYPVEINCVVSGSP---HPKVYWLFDDKPLEPDSAAYELT------NNGETLKIVRSQVEHAGTYTCEAQNNVGKARKDFLVRVTAP 2760

HSP 6 Score: 52.373 bits (124), Expect = 2.390e-6
Identity = 104/492 (21.14%), Postives = 177/492 (35.98%), Query Frame = 3

Query:  624 IPND---LSAGNYDLQITDVNLEDEGDFYC-QMNIKNNAITSQRAQLHVLVASGPPKIIQIGNQGMGPEKLRNENSPIVVDNGDLMALRCQAERGRPGARLTW--------MIDNEIIEPDLSGNFNGIISGTITNISKKIVNNTKLRDSFSTLKAKVNQLLNGKSIKCSATNRGFEKFNFPEAKAKIEIHVAPTVTMDIVSQNLGNEFSENDWITISCSALGRPDKFLWKWYINDNE-----VMNDNRSSYKIKATRTMNKAVVKCIANN--GKEGHDLRMLNVKYGPQFKDDSPPLYPANIGDDVTLTCNTD-----SNPMANIYWQRES---------NNDIIGHGTILYRKNIQELDFGTYICTA----GVENFDLKSKKIILAKRIKPMIRENPDHRASLGRSVQAKCVIDSIPIANHNQIMWLYRGRRLINDNTKYSISTEKYVDHSISILSINNIQASDFGQYNCSVTTDLGSASKVMVLSKTSP 1988
            +PND       NYDL+I  V  ED G + C  +N   N  T   A++      G P  ++ G            N   V++N D + + C     RP   ++W        + D   I PD S                  +N  KL D              GK I C A+N         +    ++I V P +    +  N     +   ++    S + +PD    K  ++ N      ++  N  ++ I+  +  ++    C A N  GK  HD   L+V   P+F            GD +TLTC        ++ + ++ W ++S         N DI   G  L        + G Y C A    G  + + K +  IL+  +  + R +   + ++ +    +C +   P  +   I WL  G+ + +D     +   +       +L I    +   G+++C    D G     MVL   +P
Sbjct: 3431 VPNDSRHTIVNNYDLKINSVTTEDAGQYSCIAVNEAGNLTTHYAAEV-----IGKPTFVRKGG-----------NLYEVIEN-DTITMDCGV-TSRPLPSISWFRGDKPVYLYDRYSISPDGS---------------HITINKAKLSDG-------------GKYI-CRASNEA----GTSDIDLILKILVPPKIDKSNIIGNPLAIVARTIYLECPISGIPQPDVIWTKNGMDINMTDSRVILAQNNETFGIENVQVTDQGRYTCTATNRGGKASHDFS-LDVLSPPEFDIHGTQPTIKREGDTITLTCPIKLAEDIADQVMDVSWTKDSRALDGDLTDNVDISDDGRKLTISQASLENAGLYTCIALNRAGEASLEFKVE--ILSPPVIDISRNDVQPQVAVNQPTIMRCAVTGHPFPS---IKWLKNGKEVTDDENIRIVEQGQ-------VLQILRTDSDHAGKWSCVAENDAGVKELEMVLDVFTP 3858

HSP 7 Score: 52.373 bits (124), Expect = 2.578e-6
Identity = 99/414 (23.91%), Postives = 160/414 (38.65%), Query Frame = 3

Query:  804 GMGPEKLRNENSPIVVDNGDLMALRCQAERGRPGARLTWMIDNEIIEPDLSGNFNGIISGTITNISKKIVNNTKLRDSFSTLKAKVNQLLNGKSIKCSATNRGFEKFNFPEAKAKIEIHVAPTVTMDIVSQNLGNEFSENDWITISCSALGRPDKFLWKWYIND---NEVMNDNRSSYKIKATRTMNKAVVKCIANNGKEGHDLRM--LNVKYGPQFKDDSPPLYPANIGDDVTLTCNTDSNPMANIYWQRES---NNDIIGHGT----ILYRKNIQELDFGTYIC-TAGVENFDLKSKKIILAKRIKPMIRENPDHRASL-GRSVQAKCVIDSIPIANHNQIMWLYRGRRLINDNTKYSISTEKYVDHSISILSINNIQASDFGQYNCSVTTDLGSASKVMVLSKTSPIPLIL 2003
            GM  + +   NS   V +G+  A+ C    G P   +TW +D   I P+ S +F      T+T  +  IV   K   S+S +              C ATN   +     E K  I I   P ++    S N+      +D  TI C   G P K +  W ++D    E + +   S  I      ++    C A N   G+D R   L V   P    ++     A   DD+ L C   + P     W  E    ++ +I H       L  +N++  + G ++C  + +   D  S  + + ++ K +I E P     + G +++  C    +P        W   G  L  D  K+S+        ++  L I     +D G YNC VT + G++     +    P P+IL
Sbjct:  997 GMDEKHVAVVNSTHDVLDGEGFAIPCVVS-GTPPPIITWYLDGRPITPN-SRDF------TVTADNTLIVR--KADKSYSGVYT------------CQATNSAGDN----EQKTTIRIMNTPMISPGQSSFNM----VVDDLFTIPCDVYGDP-KPVITWLLDDKPFTEGVVNEDGSLTIPNVNEAHRGTFTCHAQNAA-GNDTRTVTLTVHTTPTINAENQEKI-ALQNDDIVLECPAKALPPPVRLWTYEGEKIDSQLIPHTIREDGALVLQNVKLENTGVFVCQVSNLAGEDSLSYTLTVHEKPK-IISEVPGVVDVVKGFTIEIPCRATGVPEVIRT---WNKNGIDLKMDEKKFSVD-------NLGTLRIYEADKNDIGNYNCVVTNEAGTSQMTTHVDVQEP-PIIL 1365

HSP 8 Score: 51.2174 bits (121), Expect = 5.146e-6
Identity = 128/536 (23.88%), Postives = 211/536 (39.37%), Query Frame = 3

Query:  468 QRVTLNSTVTIQCRVQPIKNMKVYWVKSGFGLGETRSDIRSFGMVGNKVRYDIPNDLSAGNYDLQITDVNLEDEGDFYCQMNIKNNAITSQRA-QLHVLVASGPPKIIQIGNQGMGPEKLRNENSPIVVDNGDLMALRCQAERGRPGARLTWMIDNEIIEPDLSGNFNGIISGTITNISKKIVNNTKLRDSFSTLKAKVNQLLNGKSIKCSATN-RGFEKFNFPEAKAKIEIHVAPTVTMDIVSQNLGNEF---SENDWITISCSALGRPD-----KFLWKWYINDNEVMNDNRSSYKIKATRTMNKAVVKCIANNGKEGHDLRM--LNVKYGPQFKDDSPPLYPANIGDDVTLTCNTDSNPMANIYWQRES---NNDIIGHGTILYRK-----NIQELDFGTYICTAGVENFDLKSKK-IILAKRIKP-MIRENPDHRASLGRSVQAKCVIDSIPIANHNQIMWLYRGRRLINDNTKYSISTEKYVDHSISILSINNIQASDFGQYNCSVTTDLGS--ASKVMVLSKTS--PIPL 1997
            ++V       I+C V+     +V W+++G  + ET       G+ G  VRY     ++ G   L I +    D G + C     N A ++Q+A  L VLV+   PKII      + P             +G   +L C A RG P   ++W ++   I+   +G+  G   GT+                    KA+   L+     +C+A N  G +   FP     ++  VAP ++        GN +   SE     I C            K       ++N + +++    KI +TR  ++    C A N K G+  +   LNV   P+  +  P     + GD VTL C     P   I W +++    N  +       +K     +I     G Y C A  EN+   +++ I L   I P ++ E  +   +  ++V   C    IP      I W+      I +N KY I          + L+I N+   D G Y+C   +D G   A++ ++++K S  P P+
Sbjct: 4053 KQVIEGELAVIECLVEGYPAPQVSWLRNGNRV-ET-------GVQG--VRY-----VTDGRM-LTIIEARSLDSGIYLCSAT--NEAGSAQQAYTLEVLVS---PKIITSTPGVLTPS------------SGSKFSLPC-AVRGYPDPIISWTLNGNDIKDGENGHTIGA-DGTL-----------------HIEKAEERHLI----YECTAKNDAGADTLEFP-----VQTIVAPKISTS------GNRYINGSEGTETVIKCEIESESSEFSWSKNGVPLLPSNNLIFSEDYKLIKILSTRLSDQGEYSCTAAN-KAGNATQKTNLNVGVAPKIME-RPRTQVVHKGDQVTLWCEASGVPQPAITWYKDNELLTNTGVDETATTKKKSVIFSSISPSQAGVYTCKA--ENWVASTEEDIDLIVMIPPEVVPERMNVSTNPRQTVFLSCNATGIP---EPVISWMRDSNIAIQNNEKYQILG--------TTLAIRNVLPDDDGFYHCIAKSDAGQKIATRKLIVNKPSDRPAPI 4506

[Close]

BLAST of NEPH-2 vs. Ensembl Fly
Match: kirre (gene:FBgn0028369 transcript:FBtr0332492)

HSP 1 Score: 174.866 bits (442), Expect = 2.761e-44
Identity = 145/539 (26.90%), Postives = 246/539 (45.64%), Query Frame = 3

Query:  441 NYINVHPENQRVTLNSTVTIQCRVQPIKNMKVYWVKSGFGLGETR--SDIRSFGMVGNKVRYDIPNDLSAGNYDLQITDVNLEDEGDFYCQMN---IKNNAITSQRAQLHVLVASGPPKIIQIGNQGMGPEKLRNENSPIVVDNGDLMALRCQAERGRPGARLTWMIDNEIIEPDLSGNFNGIISGTITNISKKIVNNTKLRDSFSTLKAKVNQLLNGKSIKCSATNRGFEKFNFPEAKAKIEIHVAPTVTMDIVSQNL-GNEFSENDWITISCSALGRPDKFLWKWYINDNEVMNDNRSSYKIK-ATRTMNKAVVKC-IANNGKEGHDLRMLNVKYGPQFKDDSPPLYPANIGDDVTLTCNTDSNPMANIYWQRESNNDIIGHGTILYRKNIQELDFGTYICTAGVENF-DLKSKKIILAKRIKPMIRENPDHRASLGRSVQAKCVIDSIPIANHNQIMWLYRGRRLIN----DNTKYSISTEKYVDHSISILSINNIQASDFGQYNCSVTTDLGSASKVM-VLSKTSPIPLILIVGG 2015
             +  + P++Q   + S VT+ CRV   K   + W K  FGLG+ R  S    + MVG+            G++ L I  + L+D+  + CQ+         I S+ A+L VLV    PKI Q      G   +  E+  I         L C ++ G+P A +TW+        D  GN   +++  I  + + + ++ ++  + S LK    +  +  +  C A N     +    AK  +E+  AP V + +V   L G +  E   + +SC A   P +  ++W+IND  +  D  +   I   +R  + A+VKC + N   +    + L++ +GP F+   P    A++G  V++ C+   NP   I W  E+++ ++G    L  K   E   G Y C A V  F ++ ++  +  KR  P+I  +      +G  V+  C+  SIP A H  I+W + G ++IN    D   Y        +   + L I + +A+ FG+YNC+V    G  S V+ +L +   IP++L+V G
Sbjct:   82 QHFAMEPQDQTAVVGSRVTLPCRVME-KVGALQWTKDDFGLGQHRNLSGFERYSMVGSD---------EEGDFSLDIYPLMLDDDAKYQCQVGPGPQGEQGIRSRFAKLTVLVPPEAPKITQ------GDYLVTTEDREI--------ELECVSQGGKPAAEITWI--------DGLGN---VLTKGIEYVKEPLADSRRI-TARSILKLAPKKEHHNTTFTCQAQNTADRTYR--SAKLLLEVKYAPKVIVSVVGGALAGGKIPEGAEVILSCQADANPHELSYRWFINDELMTGDFTTKMIIHNVSRQYHDAIVKCEVVNAVGKSEQSKKLDISFGPVFR-QRPVSVEADLGATVSMRCDVAGNPEPEIEWISENSDQVVGVAAELKLKVSSETA-GRYFCKAVVNGFPEIGAEATLYVKR-APIITSHKVQFGGVGGRVKIDCLAFSIPKAEH--ILWSFEG-KIINMSSADPDIYIFEEHHLPEGVRAALIIRDSKATHFGKYNCTVMNSYGGDSLVITLLREPGNIPVLLVVMG 576

[Close]

BLAST of NEPH-2 vs. Ensembl Fly
Match: kirre (gene:FBgn0028369 transcript:FBtr0309498)

HSP 1 Score: 174.866 bits (442), Expect = 2.761e-44
Identity = 145/539 (26.90%), Postives = 246/539 (45.64%), Query Frame = 3

Query:  441 NYINVHPENQRVTLNSTVTIQCRVQPIKNMKVYWVKSGFGLGETR--SDIRSFGMVGNKVRYDIPNDLSAGNYDLQITDVNLEDEGDFYCQMN---IKNNAITSQRAQLHVLVASGPPKIIQIGNQGMGPEKLRNENSPIVVDNGDLMALRCQAERGRPGARLTWMIDNEIIEPDLSGNFNGIISGTITNISKKIVNNTKLRDSFSTLKAKVNQLLNGKSIKCSATNRGFEKFNFPEAKAKIEIHVAPTVTMDIVSQNL-GNEFSENDWITISCSALGRPDKFLWKWYINDNEVMNDNRSSYKIK-ATRTMNKAVVKC-IANNGKEGHDLRMLNVKYGPQFKDDSPPLYPANIGDDVTLTCNTDSNPMANIYWQRESNNDIIGHGTILYRKNIQELDFGTYICTAGVENF-DLKSKKIILAKRIKPMIRENPDHRASLGRSVQAKCVIDSIPIANHNQIMWLYRGRRLIN----DNTKYSISTEKYVDHSISILSINNIQASDFGQYNCSVTTDLGSASKVM-VLSKTSPIPLILIVGG 2015
             +  + P++Q   + S VT+ CRV   K   + W K  FGLG+ R  S    + MVG+            G++ L I  + L+D+  + CQ+         I S+ A+L VLV    PKI Q      G   +  E+  I         L C ++ G+P A +TW+        D  GN   +++  I  + + + ++ ++  + S LK    +  +  +  C A N     +    AK  +E+  AP V + +V   L G +  E   + +SC A   P +  ++W+IND  +  D  +   I   +R  + A+VKC + N   +    + L++ +GP F+   P    A++G  V++ C+   NP   I W  E+++ ++G    L  K   E   G Y C A V  F ++ ++  +  KR  P+I  +      +G  V+  C+  SIP A H  I+W + G ++IN    D   Y        +   + L I + +A+ FG+YNC+V    G  S V+ +L +   IP++L+V G
Sbjct:   82 QHFAMEPQDQTAVVGSRVTLPCRVME-KVGALQWTKDDFGLGQHRNLSGFERYSMVGSD---------EEGDFSLDIYPLMLDDDAKYQCQVGPGPQGEQGIRSRFAKLTVLVPPEAPKITQ------GDYLVTTEDREI--------ELECVSQGGKPAAEITWI--------DGLGN---VLTKGIEYVKEPLADSRRI-TARSILKLAPKKEHHNTTFTCQAQNTADRTYR--SAKLLLEVKYAPKVIVSVVGGALAGGKIPEGAEVILSCQADANPHELSYRWFINDELMTGDFTTKMIIHNVSRQYHDAIVKCEVVNAVGKSEQSKKLDISFGPVFR-QRPVSVEADLGATVSMRCDVAGNPEPEIEWISENSDQVVGVAAELKLKVSSETA-GRYFCKAVVNGFPEIGAEATLYVKR-APIITSHKVQFGGVGGRVKIDCLAFSIPKAEH--ILWSFEG-KIINMSSADPDIYIFEEHHLPEGVRAALIIRDSKATHFGKYNCTVMNSYGGDSLVITLLREPGNIPVLLVVMG 576

[Close]

BLAST of NEPH-2 vs. Ensembl Fly
Match: kirre (gene:FBgn0028369 transcript:FBtr0070560)

HSP 1 Score: 174.866 bits (442), Expect = 2.761e-44
Identity = 145/539 (26.90%), Postives = 246/539 (45.64%), Query Frame = 3

Query:  441 NYINVHPENQRVTLNSTVTIQCRVQPIKNMKVYWVKSGFGLGETR--SDIRSFGMVGNKVRYDIPNDLSAGNYDLQITDVNLEDEGDFYCQMN---IKNNAITSQRAQLHVLVASGPPKIIQIGNQGMGPEKLRNENSPIVVDNGDLMALRCQAERGRPGARLTWMIDNEIIEPDLSGNFNGIISGTITNISKKIVNNTKLRDSFSTLKAKVNQLLNGKSIKCSATNRGFEKFNFPEAKAKIEIHVAPTVTMDIVSQNL-GNEFSENDWITISCSALGRPDKFLWKWYINDNEVMNDNRSSYKIK-ATRTMNKAVVKC-IANNGKEGHDLRMLNVKYGPQFKDDSPPLYPANIGDDVTLTCNTDSNPMANIYWQRESNNDIIGHGTILYRKNIQELDFGTYICTAGVENF-DLKSKKIILAKRIKPMIRENPDHRASLGRSVQAKCVIDSIPIANHNQIMWLYRGRRLIN----DNTKYSISTEKYVDHSISILSINNIQASDFGQYNCSVTTDLGSASKVM-VLSKTSPIPLILIVGG 2015
             +  + P++Q   + S VT+ CRV   K   + W K  FGLG+ R  S    + MVG+            G++ L I  + L+D+  + CQ+         I S+ A+L VLV    PKI Q      G   +  E+  I         L C ++ G+P A +TW+        D  GN   +++  I  + + + ++ ++  + S LK    +  +  +  C A N     +    AK  +E+  AP V + +V   L G +  E   + +SC A   P +  ++W+IND  +  D  +   I   +R  + A+VKC + N   +    + L++ +GP F+   P    A++G  V++ C+   NP   I W  E+++ ++G    L  K   E   G Y C A V  F ++ ++  +  KR  P+I  +      +G  V+  C+  SIP A H  I+W + G ++IN    D   Y        +   + L I + +A+ FG+YNC+V    G  S V+ +L +   IP++L+V G
Sbjct:   82 QHFAMEPQDQTAVVGSRVTLPCRVME-KVGALQWTKDDFGLGQHRNLSGFERYSMVGSD---------EEGDFSLDIYPLMLDDDAKYQCQVGPGPQGEQGIRSRFAKLTVLVPPEAPKITQ------GDYLVTTEDREI--------ELECVSQGGKPAAEITWI--------DGLGN---VLTKGIEYVKEPLADSRRI-TARSILKLAPKKEHHNTTFTCQAQNTADRTYR--SAKLLLEVKYAPKVIVSVVGGALAGGKIPEGAEVILSCQADANPHELSYRWFINDELMTGDFTTKMIIHNVSRQYHDAIVKCEVVNAVGKSEQSKKLDISFGPVFR-QRPVSVEADLGATVSMRCDVAGNPEPEIEWISENSDQVVGVAAELKLKVSSETA-GRYFCKAVVNGFPEIGAEATLYVKR-APIITSHKVQFGGVGGRVKIDCLAFSIPKAEH--ILWSFEG-KIINMSSADPDIYIFEEHHLPEGVRAALIIRDSKATHFGKYNCTVMNSYGGDSLVITLLREPGNIPVLLVVMG 576

[Close]

BLAST of NEPH-2 vs. Ensembl Fly
Match: kirre (gene:FBgn0028369 transcript:FBtr0309499)

HSP 1 Score: 174.866 bits (442), Expect = 2.761e-44
Identity = 145/539 (26.90%), Postives = 246/539 (45.64%), Query Frame = 3

Query:  441 NYINVHPENQRVTLNSTVTIQCRVQPIKNMKVYWVKSGFGLGETR--SDIRSFGMVGNKVRYDIPNDLSAGNYDLQITDVNLEDEGDFYCQMN---IKNNAITSQRAQLHVLVASGPPKIIQIGNQGMGPEKLRNENSPIVVDNGDLMALRCQAERGRPGARLTWMIDNEIIEPDLSGNFNGIISGTITNISKKIVNNTKLRDSFSTLKAKVNQLLNGKSIKCSATNRGFEKFNFPEAKAKIEIHVAPTVTMDIVSQNL-GNEFSENDWITISCSALGRPDKFLWKWYINDNEVMNDNRSSYKIK-ATRTMNKAVVKC-IANNGKEGHDLRMLNVKYGPQFKDDSPPLYPANIGDDVTLTCNTDSNPMANIYWQRESNNDIIGHGTILYRKNIQELDFGTYICTAGVENF-DLKSKKIILAKRIKPMIRENPDHRASLGRSVQAKCVIDSIPIANHNQIMWLYRGRRLIN----DNTKYSISTEKYVDHSISILSINNIQASDFGQYNCSVTTDLGSASKVM-VLSKTSPIPLILIVGG 2015
             +  + P++Q   + S VT+ CRV   K   + W K  FGLG+ R  S    + MVG+            G++ L I  + L+D+  + CQ+         I S+ A+L VLV    PKI Q      G   +  E+  I         L C ++ G+P A +TW+        D  GN   +++  I  + + + ++ ++  + S LK    +  +  +  C A N     +    AK  +E+  AP V + +V   L G +  E   + +SC A   P +  ++W+IND  +  D  +   I   +R  + A+VKC + N   +    + L++ +GP F+   P    A++G  V++ C+   NP   I W  E+++ ++G    L  K   E   G Y C A V  F ++ ++  +  KR  P+I  +      +G  V+  C+  SIP A H  I+W + G ++IN    D   Y        +   + L I + +A+ FG+YNC+V    G  S V+ +L +   IP++L+V G
Sbjct:   82 QHFAMEPQDQTAVVGSRVTLPCRVME-KVGALQWTKDDFGLGQHRNLSGFERYSMVGSD---------EEGDFSLDIYPLMLDDDAKYQCQVGPGPQGEQGIRSRFAKLTVLVPPEAPKITQ------GDYLVTTEDREI--------ELECVSQGGKPAAEITWI--------DGLGN---VLTKGIEYVKEPLADSRRI-TARSILKLAPKKEHHNTTFTCQAQNTADRTYR--SAKLLLEVKYAPKVIVSVVGGALAGGKIPEGAEVILSCQADANPHELSYRWFINDELMTGDFTTKMIIHNVSRQYHDAIVKCEVVNAVGKSEQSKKLDISFGPVFR-QRPVSVEADLGATVSMRCDVAGNPEPEIEWISENSDQVVGVAAELKLKVSSETA-GRYFCKAVVNGFPEIGAEATLYVKR-APIITSHKVQFGGVGGRVKIDCLAFSIPKAEH--ILWSFEG-KIINMSSADPDIYIFEEHHLPEGVRAALIIRDSKATHFGKYNCTVMNSYGGDSLVITLLREPGNIPVLLVVMG 576

[Close]

BLAST of NEPH-2 vs. Ensembl Fly
Match: kirre (gene:FBgn0028369 transcript:FBtr0070559)

HSP 1 Score: 174.866 bits (442), Expect = 2.761e-44
Identity = 145/539 (26.90%), Postives = 246/539 (45.64%), Query Frame = 3

Query:  441 NYINVHPENQRVTLNSTVTIQCRVQPIKNMKVYWVKSGFGLGETR--SDIRSFGMVGNKVRYDIPNDLSAGNYDLQITDVNLEDEGDFYCQMN---IKNNAITSQRAQLHVLVASGPPKIIQIGNQGMGPEKLRNENSPIVVDNGDLMALRCQAERGRPGARLTWMIDNEIIEPDLSGNFNGIISGTITNISKKIVNNTKLRDSFSTLKAKVNQLLNGKSIKCSATNRGFEKFNFPEAKAKIEIHVAPTVTMDIVSQNL-GNEFSENDWITISCSALGRPDKFLWKWYINDNEVMNDNRSSYKIK-ATRTMNKAVVKC-IANNGKEGHDLRMLNVKYGPQFKDDSPPLYPANIGDDVTLTCNTDSNPMANIYWQRESNNDIIGHGTILYRKNIQELDFGTYICTAGVENF-DLKSKKIILAKRIKPMIRENPDHRASLGRSVQAKCVIDSIPIANHNQIMWLYRGRRLIN----DNTKYSISTEKYVDHSISILSINNIQASDFGQYNCSVTTDLGSASKVM-VLSKTSPIPLILIVGG 2015
             +  + P++Q   + S VT+ CRV   K   + W K  FGLG+ R  S    + MVG+            G++ L I  + L+D+  + CQ+         I S+ A+L VLV    PKI Q      G   +  E+  I         L C ++ G+P A +TW+        D  GN   +++  I  + + + ++ ++  + S LK    +  +  +  C A N     +    AK  +E+  AP V + +V   L G +  E   + +SC A   P +  ++W+IND  +  D  +   I   +R  + A+VKC + N   +    + L++ +GP F+   P    A++G  V++ C+   NP   I W  E+++ ++G    L  K   E   G Y C A V  F ++ ++  +  KR  P+I  +      +G  V+  C+  SIP A H  I+W + G ++IN    D   Y        +   + L I + +A+ FG+YNC+V    G  S V+ +L +   IP++L+V G
Sbjct:   82 QHFAMEPQDQTAVVGSRVTLPCRVME-KVGALQWTKDDFGLGQHRNLSGFERYSMVGSD---------EEGDFSLDIYPLMLDDDAKYQCQVGPGPQGEQGIRSRFAKLTVLVPPEAPKITQ------GDYLVTTEDREI--------ELECVSQGGKPAAEITWI--------DGLGN---VLTKGIEYVKEPLADSRRI-TARSILKLAPKKEHHNTTFTCQAQNTADRTYR--SAKLLLEVKYAPKVIVSVVGGALAGGKIPEGAEVILSCQADANPHELSYRWFINDELMTGDFTTKMIIHNVSRQYHDAIVKCEVVNAVGKSEQSKKLDISFGPVFR-QRPVSVEADLGATVSMRCDVAGNPEPEIEWISENSDQVVGVAAELKLKVSSETA-GRYFCKAVVNGFPEIGAEATLYVKR-APIITSHKVQFGGVGGRVKIDCLAFSIPKAEH--ILWSFEG-KIINMSSADPDIYIFEEHHLPEGVRAALIIRDSKATHFGKYNCTVMNSYGGDSLVITLLREPGNIPVLLVVMG 576

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BLAST of NEPH-2 vs. Ensembl Zebrafish
Match: kirrel3a (kirre like nephrin family adhesion molecule 3a [Source:ZFIN;Acc:ZDB-GENE-091117-44])

HSP 1 Score: 163.31 bits (412), Expect = 8.576e-42
Identity = 134/523 (25.62%), Postives = 225/523 (43.02%), Query Frame = 3

Query:  456 HPENQRVTLNSTVTIQCRVQPIKNMKVYWVKSGFGLGETRSDIRSFGMVGNKVRYDIPNDLSAGNYDLQITDVNLEDEGDFYCQMNIKNNAITSQRAQLHVLVASGPPKIIQIGNQGMGPEKLRNENSPIV-VDNGDLMALRCQAERGRPGARLTWMIDNEIIEPDLSGNFNGIISGTITNISKKIVNNTKLRDSFSTLKAKVNQLLNGKSIKCSATNRGFEKFNFPEAKAKIEIHVAPTVTMDIVSQNLGNEFSENDWITISCSALGRPDKFLWKWYINDNEVMNDNRSSYKIKATRTMNKAVVKCIANNGKEGHDL-RMLNVKYGPQFKDDSPPLYPANIGDDVTLTCNTDSNPMANIYWQRESNNDIIGHGTILYRKNIQELDFGTYICTAGVENFDLKSKKIILAKRIKPMIRENPDHRASLGRSVQAKCVIDSIPIANHNQIMWLYRGRRLINDNT-KYSISTEKYVDHSISILSINNIQASDFGQ-YNCSVTTDLGSASKVMVLSKTSPIPLILIVG 2012
             P +  +     VT+ C +   + M V WVK G  LG  R D+  +       RYD+  D S G Y L I    L D+G F CQ      A  S+ AQL VLV    P II                +P+V +  GD + L C A   +P A + W+ + E+I        NG         +K ++ + K   + STL    + + +G+ I C A+N+     N  EA   I+I   P V + +  Q +     E + +   C+A   P    ++W    + + +    +Y++    +     V C   N     ++ R ++V +GP+   + P     + G D   +C    NP   I W +  +  ++ +   L  K +++ D G Y+C A V    +  K+++L     P I      +A  G   Q KC I S P    ++I W ++   L +  + +Y++ T    +  IS L++ NI  +DF   YNC+     GS ++++ L +   + L +I+G
Sbjct:   26 QPHDLVIVAGEPVTLPCTIIGYQGM-VLWVKDGLALGVNR-DLSGYP------RYDVIGDHSKGEYHLLIERTELVDDGSFECQA--IQVAGRSRPAQLTVLVPPDDPVII---------------GAPVVSLRAGDSLNLTCHANNAKPAASIIWIRNGEVI--------NG------AAYTKTLLRDGKRESTVSTLHISASNIESGQQITCRASNKAAP--NGKEATVTIDIQHFPLVNLSVEPQPV----LEGNLVKFHCAAKANPPVTHYRWAKGGSMITDATGDTYEVLVDHSFFTEPVSCEVTNALGSTNISRNVDVYFGPRLAAE-PQSLQVDRGSDAVFSCAWIGNPSLTIVWMKRGHGVVLSNENTLTLKAVRQEDAGKYVCRAVVPRVGVGEKEVMLTVNGPPSISSTQTQQALYGEKGQIKCFIRSTP--PPDRIAWSWKETVLESGTSGRYTVETVSTEEGVISTLTMRNIVPTDFQTIYNCTAWNSFGSDTEIIRLKEQGSLRLAVIIG 500

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BLAST of NEPH-2 vs. Ensembl Zebrafish
Match: kirrel3a (kirre like nephrin family adhesion molecule 3a [Source:ZFIN;Acc:ZDB-GENE-091117-44])

HSP 1 Score: 164.466 bits (415), Expect = 3.269e-41
Identity = 134/523 (25.62%), Postives = 225/523 (43.02%), Query Frame = 3

Query:  456 HPENQRVTLNSTVTIQCRVQPIKNMKVYWVKSGFGLGETRSDIRSFGMVGNKVRYDIPNDLSAGNYDLQITDVNLEDEGDFYCQMNIKNNAITSQRAQLHVLVASGPPKIIQIGNQGMGPEKLRNENSPIV-VDNGDLMALRCQAERGRPGARLTWMIDNEIIEPDLSGNFNGIISGTITNISKKIVNNTKLRDSFSTLKAKVNQLLNGKSIKCSATNRGFEKFNFPEAKAKIEIHVAPTVTMDIVSQNLGNEFSENDWITISCSALGRPDKFLWKWYINDNEVMNDNRSSYKIKATRTMNKAVVKCIANNGKEGHDL-RMLNVKYGPQFKDDSPPLYPANIGDDVTLTCNTDSNPMANIYWQRESNNDIIGHGTILYRKNIQELDFGTYICTAGVENFDLKSKKIILAKRIKPMIRENPDHRASLGRSVQAKCVIDSIPIANHNQIMWLYRGRRLINDNT-KYSISTEKYVDHSISILSINNIQASDFGQ-YNCSVTTDLGSASKVMVLSKTSPIPLILIVG 2012
             P +  +     VT+ C +   + M V WVK G  LG  R D+  +       RYD+  D S G Y L I    L D+G F CQ      A  S+ AQL VLV    P II                +P+V +  GD + L C A   +P A + W+ + E+I        NG         +K ++ + K   + STL    + + +G+ I C A+N+     N  EA   I+I   P V + +  Q +     E + +   C+A   P    ++W    + + +    +Y++    +     V C   N     ++ R ++V +GP+   + P     + G D   +C    NP   I W +  +  ++ +   L  K +++ D G Y+C A V    +  K+++L     P I      +A  G   Q KC I S P    ++I W ++   L +  + +Y++ T    +  IS L++ NI  +DF   YNC+     GS ++++ L +   + L +I+G
Sbjct:   26 QPHDLVIVAGEPVTLPCTIIGYQGM-VLWVKDGLALGVNR-DLSGYP------RYDVIGDHSKGEYHLLIERTELVDDGSFECQA--IQVAGRSRPAQLTVLVPPDDPVII---------------GAPVVSLRAGDSLNLTCHANNAKPAASIIWIRNGEVI--------NG------AAYTKTLLRDGKRESTVSTLHISASNIESGQQITCRASNKAAP--NGKEATVTIDIQHFPLVNLSVEPQPV----LEGNLVKFHCAAKANPPVTHYRWAKGGSMITDATGDTYEVLVDHSFFTEPVSCEVTNALGSTNISRNVDVYFGPRLAAE-PQSLQVDRGSDAVFSCAWIGNPSLTIVWMKRGHGVVLSNENTLTLKAVRQEDAGKYVCRAVVPRVGVGEKEVMLTVNGPPSISSTQTQQALYGEKGQIKCFIRSTPPP--DRIAWSWKETVLESGTSGRYTVETVSTEEGVISTLTMRNIVPTDFQTIYNCTAWNSFGSDTEIIRLKEQGSLRLAVIIG 500

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Query:  456 HPENQRVTLNSTVTIQCRVQPIKNMKVYWVKSGFGLGETRSDIRSFGMVGNKVRYDIPNDLSAGNYDLQITDVNLEDEGDFYCQMNIKNNAITSQRAQLHVLVASGPPKIIQIGNQGMGPEKLRNENSPIV-VDNGDLMALRCQAERGRPGARLTWMIDNEIIEPDLSGNFNGIISGTITNISKKIVNNTKLRDSFSTLKAKVNQLLNGKSIKCSATNRGFEKFNFPEAKAKIEIHVAPTVTMDIVSQNLGNEFSENDWITISCSALGRPDKFLWKWYINDNEVMNDNRSSYKIKATRTMNKAVVKCIANNGKEGHDL-RMLNVKYGPQFKDDSPPLYPANIGDDVTLTCNTDSNPMANIYWQRESNNDIIGHGTILYRKNIQELDFGTYICTAGVENFDLKSKKIILAKRIKPMIRENPDHRASLGRSVQAKCVIDSIPIANHNQIMWLYRGRRLINDNT-KYSISTEKYVDHSISILSINNIQASDFGQ-YNCSVTTDLGSASKVMVLSKTSPIPLILIVG 2012
             P +  +     VT+ C +   + M V WVK G  LG  R D+  +       RYD+  D S G Y L I    L D+G F CQ      A  S+ AQL VLV    P II                +P+V +  GD + L C A   +P A + W+ + E+I        NG         +K ++ + K   + STL    + + +G+ I C A+N+     N  EA   I+I   P V + +  Q +     E + +   C+A   P    ++W    + + +    +Y++    +     V C   N     ++ R ++V +GP+   + P     + G D   +C    NP   I W +  +  ++ +   L  K +++ D G Y+C A V    +  K+++L     P I      +A  G   Q KC I S P    ++I W ++   L +  + +Y++ T    +  IS L++ NI  +DF   YNC+     GS ++++ L +   + L +I+G
Sbjct:   26 QPHDLVIVAGEPVTLPCTIIGYQGM-VLWVKDGLALGVNR-DLSGYP------RYDVIGDHSKGEYHLLIERTELVDDGSFECQA--IQVAGRSRPAQLTVLVPPDDPVII---------------GAPVVSLRAGDSLNLTCHANNAKPAASIIWIRNGEVI--------NG------AAYTKTLLRDGKRESTVSTLHISASNIESGQQITCRASNKAAP--NGKEATVTIDIQHFPLVNLSVEPQPV----LEGNLVKFHCAAKANPPVTHYRWAKGGSMITDATGDTYEVLVDHSFFTEPVSCEVTNALGSTNISRNVDVYFGPRLAAE-PQSLQVDRGSDAVFSCAWIGNPSLTIVWMKRGHGVVLSNENTLTLKAVRQEDAGKYVCRAVVPRVGVGEKEVMLTVNGPPSISSTQTQQALYGEKGQIKCFIRSTPPP--DRIAWSWKETVLESGTSGRYTVETVSTEEGVISTLTMRNIVPTDFQTIYNCTAWNSFGSDTEIIRLKEQGSLRLAVIIG 500

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BLAST of NEPH-2 vs. Ensembl Zebrafish
Match: KIRREL3 (kirre like nephrin family adhesion molecule 3 [Source:HGNC Symbol;Acc:HGNC:23204])

HSP 1 Score: 155.606 bits (392), Expect = 2.992e-39
Identity = 127/512 (24.80%), Postives = 222/512 (43.36%), Query Frame = 3

Query:  456 HPENQRVTLNSTVTIQCRVQPIKNMKVYWVKSGFGLGETRSDIRSFGMVGNKVRYDIPNDLSAGNYDLQITDVNLEDEGDFYCQMNIKNNAITSQRAQLHVLVASGPPKIIQIGNQGMGPEKLRNENSPIV-VDNGDLMALRCQAERGRPGARLTWMIDNEIIEPDLSGNFNGIISGTITNISKKIVNNTKLRDSFSTLKAKVNQLLNGKSIKCSATNRGFEKFNFPEAKAKIEIHVAPTVTMDIVSQNLGNEFSENDWITISCSALGRPDKFLWKWYINDNEVMNDNRSSYKIKATRTMNKAVVKCIANNGKEGHDL-RMLNVKYGPQFKDDSPPLYPANIGDDVTLTCNTDSNPMANIYWQRESNNDIIGHGTILYRKNIQELDFGTYICTAGVENFDLKSKKIILAKRIKPMIRENPDHRASLGRSVQAKCVIDSIPIANHNQIMWLYRGRRLINDNT-KYSISTEKYVDHSISILSINNIQASDFGQ-YNCSVTTDLGSASKVMVLSK 1979
             P++  V     VT+ C + P  +  V W++ G  LG  R D+  +       RY +  D  +G + L+I  V L D+  F CQ      A+ S+ A+L VLV    P I                  P+V +  GD + L C A+  +P A + W+ + E++        NG +       SK ++ + +   + STL    + + +G+ I C A+N+     N  E    I+I   P V + +  Q +     E + +   CSA   P    +KW    + +   +  +Y++    +     V C   N     ++ R ++V +GP+   + P     ++G D    C    NP   I W +  +  ++ +  IL  K++++ D G Y+C A V       K++ L     P I     H+A  G   Q KC I S P    ++I W ++   L +  + +Y++ T    D  +S L+++NI  +DF   YNC+     GS ++++ L +
Sbjct:   39 QPQDLVVVAGQPVTLPCSI-PGYHGVVLWLRDGLALGVGR-DLSGYP------RYAVVGDHGSGEHHLRIQKVELMDDAVFECQA--IQAAMRSRPARLTVLVPPDDPMI---------------TGGPVVSLRAGDPLNLTCHADNAKPAASIIWIRNGEVL--------NGAM------YSKTLLRDGRRESTVSTLYISASNIESGQKIICRASNKAVP--NGKETSVTIDIQHLPLVNLSVEPQPV----LEGNLVKFHCSAKANPPVTQYKWAKGGSVIKEVSGDTYEVIVDHSFFTEPVSCEVTNPLGSTNISRNVDVYFGPRMAAE-PQSLQVDLGSDAVFNCAWTGNPSLTIVWMKRGSGVVLSNENILTLKSVRQEDAGKYVCRAVVPRVGAAEKEVSLTVNGPPTISSTQTHQAPHGEKGQIKCFIRSTP--PPDRIAWSWKETVLESGTSGRYTVETVSTEDGVLSTLTMSNIVPADFQTIYNCTAWNSFGSDTEIIRLKE 502

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BLAST of NEPH-2 vs. Ensembl Zebrafish
Match: kirrel1a (kirre like nephrin family adhesion molecule 1a [Source:ZFIN;Acc:ZDB-GENE-040426-2126])

HSP 1 Score: 155.606 bits (392), Expect = 2.252e-38
Identity = 134/532 (25.19%), Postives = 225/532 (42.29%), Query Frame = 3

Query:  456 HPENQRVTLNSTVTIQCRVQPIKNMKVYWVKSGFGLGETRSDIRSFGMVGNKVRYDIPNDLSAGNYDLQITDVNLEDEGDFYCQMNIKNNAITSQRAQLHVLVASGPPKIIQIGNQGMGPEKLRNENSP-IVVDNGDLMALRCQAERGRPGARLTWMIDNEIIEPDLSGNFNGIISGTITNISKKIVNNTKLRDSFSTLKAKVNQLLNGKSIKCSATNRGFEKFNFPEAKAKIEIHVAPTVTMDIVSQNLGNEFSENDWITISCSALGRPDKFLWKWYINDNEVMNDNRSSYKIKATRTMNKAVVKCIANNGKEGHDLRML-NVKYGPQFKDDSPPLYPANIGDDVTLTCNTDSNPMANIYWQRESNNDIIGHGTILYRKNIQELDFGTYICTAGVENFDLKSKKIILAKRIKPMIRENPDHRASLGRSVQAKCVIDSIPIANHNQIMWLYRGRRLINDNTKYSISTEKYVDHS---------ISILSINNIQASDF-GQYNCSVTTDLGSASKVMVLSKTSPIPLILIVGG 2015
             P +Q V L   V + C V     + V W K G  LG    D+R++       RY +   +  G Y+L+I+   L D+  + CQ      A+ S+RA+L VL+    P I               E SP I++  G    + C +   +P + + W  D   IE        G +S T      +++ + K   + S L  +      GK+  C ATN          A   + +H  P VT+ I  +++     E + +T +C A   P    +KW      +     S +  KA  +     V C   N     ++ +L +V +GP    +  P+   ++  DVTL C    NP   + W ++ ++ ++ +   LY K++ + D G Y+C A V    +   ++ L     P+I   P   A  G   + KC I S P    ++I+W ++    + +  K ++S    V+ S         +S L+INNI  SDF   YNC+     GS + ++ L +   +P+ +I GG
Sbjct:   25 EPADQSVVLGQRVVLSCVVFNYSGI-VQWTKDGLALG-IGEDLRAW------PRYRVLRLVDVGQYNLEISAAELSDDSLYECQAT--EAALRSRRAKLTVLIPPDEPVI---------------EGSPEILLTAGVPYNMSCVSRGAKPASVIEWQKDGLPIE--------GAVSTT------EVLPDRKRVTTRSYLPIQPLDTDTGKNFTCVATNLAVPMGK--RATITLNVHHPPVVTLSIEPRSV----LEGERVTFTCQATANPPIMGYKWAKGGVVIQGARESVFVTKADHSFFTEPVSCQVFNAVGSTNVSILVDVHFGPILVVEPKPVT-VDVDSDVTLNCKWAGNPPLTLTWTKKGSSMVLSNNNQLYLKSVSQADAGQYVCKAIVPRIGVGETEVTLTVNGPPIISSEPFQYAVRGERGEVKCYIASTPPP--DKIVWAWKEN--VWEKEKGTLSERYTVEQSKPSAQGGAVLSTLTINNIMESDFQSTYNCTAWNSFGSGTMIISLEEMEIVPVGIIAGG 506

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BLAST of NEPH-2 vs. Ensembl Xenopus
Match: eif4e (eukaryotic translation initiation factor 4E [Source:Xenbase;Acc:XB-GENE-855435])

HSP 1 Score: 162.54 bits (410), Expect = 1.839e-40
Identity = 127/529 (24.01%), Postives = 229/529 (43.29%), Query Frame = 3

Query:  444 YINVHPENQRVTLNSTVTIQCRVQPIKNMKVYWVKSGFGLGETRSDIRSFGMVGNKVRYDIPNDLSAGNYDLQITDVNLEDEGDFYCQMNIKNNAITSQRAQLHVLVASGPPKIIQIGNQGMGPEKLRNENSPIV-VDNGDLMALRCQAERGRPGARLTWMIDNEIIEPDLSGNFNGIISGTITNISKKIVNNTKLRDSFSTLKAKVNQLLNGKSIKCSATNRGFEKFNFPEAKAK---IEIHVAPTVTMDIVSQNLGNEFSENDWITISCSALGRPDKFLWKWYINDNEVMNDNRSSYKIKATRTMNKAVVKCIANNGKEGHDLR-MLNVKYGPQFKDDSPPLYPANIGDDVTLTCNTDSNPMANIYWQRESNNDIIGHGTILYRKNIQELDFGTYICTAGVENFDLKSKKIILAKRIKPMIRENPDHRASLGRSVQAKCVIDSIPIANHNQIMWLYRGRRLINDN-TKYSISTEKYVDHSISILSINNIQASDF-GQYNCSVTTDLGSASKVMVLSKTSPIPLILIV 2009
            + +  P ++ +    +VT+ C V   + + V W   G  LG  R D+  +       RY +  D S G ++L I  V L D+  + CQ      A+ SQRA+L VL+  G P I                 SP+  V       L C A   +P A +TW  D + ++  +               +K+++++ K   S S+L    +   +G S  C   N        PE + K   + +   P VT+ +    +    +E   +T  C A+  P+   ++W       +  +   Y ++   T   A V C  +N     ++   +NV +GP+   +  P+   +IGDD +  C    NP    +W ++   +++ +G  L    +   D G Y+C A V       K++ L  R  P+I     +  +LG   + +C+I+S P    ++I+W +  + L + +  ++S+ TE     +IS+L I+  + SDF  ++NCS     G  S ++ L + + +PL L++
Sbjct:    9 HFSQQPSDKVIVAGKSVTLPCVVIGYRGV-VQWTMDGLALGAER-DLPGWS------RYSVVGDPSLGEHNLHIEGVELSDDAIYECQAT--QAALRSQRARLTVLLPPGDPMI---------------PGSPVANVLLNVPYNLTCLAPVAKPAAEITWYRDGKKLDSAV--------------YTKELLSDGKSEGSASSLLITPSLADSGSSYTCRVRNEAL-----PEGREKSVTLSVQYPPKVTLSVEPPTI----TEGGSVTFLCGAVSNPEVTGYRW-AKGGVPLAVSGDKYTVEVDHTFFTAPVSCEVSNSVGASNVSTAVNVLFGPRLLTEPRPMT-VDIGDDASFFCGWTGNPTPTQFWSKKGTGEVLSNGNTLLLTKVTREDAGIYVCKAIVPRMGSTEKEVTLTVRGPPIITSEMHYETTLGGKARMECLIESTPAP--DRIVWAWDKQSLEDGSWGRFSVETEVTEVGAISVLVIDGAEQSDFLTEFNCSAINQYGEDSVIVSLRQQAALPLTLLL 485

[Close]

BLAST of NEPH-2 vs. Ensembl Xenopus
Match: eif4e (eukaryotic translation initiation factor 4E [Source:Xenbase;Acc:XB-GENE-855435])

HSP 1 Score: 162.155 bits (409), Expect = 2.153e-40
Identity = 128/533 (24.02%), Postives = 230/533 (43.15%), Query Frame = 3

Query:  432 GNENYINVHPENQRVTLNSTVTIQCRVQPIKNMKVYWVKSGFGLGETRSDIRSFGMVGNKVRYDIPNDLSAGNYDLQITDVNLEDEGDFYCQMNIKNNAITSQRAQLHVLVASGPPKIIQIGNQGMGPEKLRNENSPIV-VDNGDLMALRCQAERGRPGARLTWMIDNEIIEPDLSGNFNGIISGTITNISKKIVNNTKLRDSFSTLKAKVNQLLNGKSIKCSATNRGFEKFNFPEAKAK---IEIHVAPTVTMDIVSQNLGNEFSENDWITISCSALGRPDKFLWKWYINDNEVMNDNRSSYKIKATRTMNKAVVKCIANNGKEGHDLR-MLNVKYGPQFKDDSPPLYPANIGDDVTLTCNTDSNPMANIYWQRESNNDIIGHGTILYRKNIQELDFGTYICTAGVENFDLKSKKIILAKRIKPMIRENPDHRASLGRSVQAKCVIDSIPIANHNQIMWLYRGRRLINDN-TKYSISTEKYVDHSISILSINNIQASDF-GQYNCSVTTDLGSASKVMVLSKTSPIPLILIV 2009
            G   + +  P ++ +    +VT+ C V   + + V W   G  LG  R D+  +       RY +  D S G ++L I  V L D+  + CQ      A+ SQRA+L VL+  G P I                 SP+  V       L C A   +P A +TW  D + ++  +               +K+++++ K   S S+L    +   +G S  C   N        PE + K   + +   P VT+ +    +    +E   +T  C A+  P+   ++W       +  +   Y ++   T   A V C  +N     ++   +NV +GP+   +  P+   +IGDD +  C    NP    +W ++   +++ +G  L    +   D G Y+C A V       K++ L  R  P+I     +  +LG   + +C+I+S P    ++I+W +  + L + +  ++S+ TE     +IS+L I+  + SDF  ++NCS     G  S ++ L + + +PL L++
Sbjct:   17 GFGAHFSQQPSDKVIVAGKSVTLPCVVIGYRGV-VQWTMDGLALGAER-DLPGWS------RYSVVGDPSLGEHNLHIEGVELSDDAIYECQAT--QAALRSQRARLTVLLPPGDPMI---------------PGSPVANVLLNVPYNLTCLAPVAKPAAEITWYRDGKKLDSAV--------------YTKELLSDGKSEGSASSLLITPSLADSGSSYTCRVRNEAL-----PEGREKSVTLSVQYPPKVTLSVEPPTI----TEGGSVTFLCGAVSNPEVTGYRW-AKGGVPLAVSGDKYTVEVDHTFFTAPVSCEVSNSVGASNVSTAVNVLFGPRLLTEPRPMT-VDIGDDASFFCGWTGNPTPTQFWSKKGTGEVLSNGNTLLLTKVTREDAGIYVCKAIVPRMGSTEKEVTLTVRGPPIITSEMHYETTLGGKARMECLIESTPAP--DRIVWAWDKQSLEDGSWGRFSVETEVTEVGAISVLVIDGAEQSDFLTEFNCSAINQYGEDSVIVSLRQQAALPLTLLL 497

[Close]

BLAST of NEPH-2 vs. Ensembl Xenopus
Match: eif4e (eukaryotic translation initiation factor 4E [Source:Xenbase;Acc:XB-GENE-855435])

HSP 1 Score: 159.073 bits (401), Expect = 3.503e-40
Identity = 128/533 (24.02%), Postives = 230/533 (43.15%), Query Frame = 3

Query:  432 GNENYINVHPENQRVTLNSTVTIQCRVQPIKNMKVYWVKSGFGLGETRSDIRSFGMVGNKVRYDIPNDLSAGNYDLQITDVNLEDEGDFYCQMNIKNNAITSQRAQLHVLVASGPPKIIQIGNQGMGPEKLRNENSPIV-VDNGDLMALRCQAERGRPGARLTWMIDNEIIEPDLSGNFNGIISGTITNISKKIVNNTKLRDSFSTLKAKVNQLLNGKSIKCSATNRGFEKFNFPEAKAK---IEIHVAPTVTMDIVSQNLGNEFSENDWITISCSALGRPDKFLWKWYINDNEVMNDNRSSYKIKATRTMNKAVVKCIANNGKEGHDLR-MLNVKYGPQFKDDSPPLYPANIGDDVTLTCNTDSNPMANIYWQRESNNDIIGHGTILYRKNIQELDFGTYICTAGVENFDLKSKKIILAKRIKPMIRENPDHRASLGRSVQAKCVIDSIPIANHNQIMWLYRGRRLINDN-TKYSISTEKYVDHSISILSINNIQASDF-GQYNCSVTTDLGSASKVMVLSKTSPIPLILIV 2009
            G   + +  P ++ +    +VT+ C V   + + V W   G  LG  R D+  +       RY +  D S G ++L I  V L D+  + CQ      A+ SQRA+L VL+  G P I                 SP+  V       L C A   +P A +TW  D + ++  +               +K+++++ K   S S+L    +   +G S  C   N        PE + K   + +   P VT+ +    +    +E   +T  C A+  P+   ++W       +  +   Y ++   T   A V C  +N     ++   +NV +GP+   +  P+   +IGDD +  C    NP    +W ++   +++ +G  L    +   D G Y+C A V       K++ L  R  P+I     +  +LG   + +C+I+S P    ++I+W +  + L + +  ++S+ TE     +IS+L I+  + SDF  ++NCS     G  S ++ L + + +PL L++
Sbjct:   21 GFGAHFSQQPSDKVIVAGKSVTLPCVVIGYRGV-VQWTMDGLALGAER-DLPGWS------RYSVVGDPSLGEHNLHIEGVELSDDAIYECQAT--QAALRSQRARLTVLLPPGDPMI---------------PGSPVANVLLNVPYNLTCLAPVAKPAAEITWYRDGKKLDSAV--------------YTKELLSDGKSEGSASSLLITPSLADSGSSYTCRVRNEAL-----PEGREKSVTLSVQYPPKVTLSVEPPTI----TEGGSVTFLCGAVSNPEVTGYRW-AKGGVPLAVSGDKYTVEVDHTFFTAPVSCEVSNSVGASNVSTAVNVLFGPRLLTEPRPMT-VDIGDDASFFCGWTGNPTPTQFWSKKGTGEVLSNGNTLLLTKVTREDAGIYVCKAIVPRMGSTEKEVTLTVRGPPIITSEMHYETTLGGKARMECLIESTPAP--DRIVWAWDKQSLEDGSWGRFSVETEVTEVGAISVLVIDGAEQSDFLTEFNCSAINQYGEDSVIVSLRQQAALPLTLLL 501

[Close]

BLAST of NEPH-2 vs. Ensembl Xenopus
Match: rps7 (ribosomal protein S7 [Source:Xenbase;Acc:XB-GENE-977326])

HSP 1 Score: 159.458 bits (402), Expect = 6.649e-40
Identity = 132/522 (25.29%), Postives = 223/522 (42.72%), Query Frame = 3

Query:  456 HPENQRVTLNSTVTIQCRVQPIKNMKVYWVKSGFGLGETRSDIRSFGMVGNKVRYDIPNDLSAGNYDLQITDVNLEDEGDFYCQMNIKNNAITSQRAQLHVLVASGPPKIIQIGNQGMGPEKLRNENSPIVVDNGDLMALRCQAERGRPGARLTWMIDNEIIEPDLSGNFNGIISGTITNISKKIVNNTKLRDSFSTLKAKVNQLLNGKSIKCSATNRGFEKFNFPEAKAKIEIHVAPTVTMDIVSQNLGNEFSENDWITISCSALGRPDKFLWKWYINDNEVMNDNRSSYKIKATRTMNKAVVKCIANNGKEGHDL-RMLNVKYGPQFKDDSPPLYPANIGDDVTLTCNTDSNPMANIYWQRESNNDIIGHGTILYRKNIQELDFGTYICTAGVENFDLKSKKIILAKRIKPMIRENPDHRASLGRSVQAKCVIDSIPIANHNQIMWLYRGRRLINDNT-KYSISTEKYVDHSISILSINNIQASDFGQ-YNCSVTTDLGSASKVMVLSKTSPIPLILIVG 2012
             P++Q V     V++ C + P  +  + W+K G  +G  R D+  +       RY +  D  +G + L I    L+D+  + CQ      AI S+ A+L VLV    P I        GP         I +  GD + L C A+  +P A +TWM + E++        NG          K ++ + K     STL    + + NG++I C ATN+        EA   I I   P V + +  Q +     E++ +   C+A   P    ++W      +      +Y+     +     V C   N     ++ R ++V +GP+   + P     ++G D T  C    NP   I W +  +  ++ +   L  KN+++ D G Y+C A V       + I L     P+I       A  G   Q KC I S P    ++I W ++   L +  + +Y++ T    +  IS L+I+NI  +DF   YNC+     GS ++++ L +   +P+ +I+G
Sbjct:   11 QPQDQVVVAGQPVSLLCAI-PGYHGLLLWIKDGLAIGVGR-DLSGYP------RYSVGGDHLSGEHHLMIQRAELQDDAMYECQA--IQAAIRSRPARLTVLVPPDDPVITG------GPV--------ISIRAGDPLNLTCHADNAKPAATITWMKNGEVL--------NG------ATYYKTLLRDGKRESIISTLFVSSSDIENGQTITCRATNKAVPGGK--EATVTINIQHPPLVNLTVEPQPV----LEDNVVKFHCAAKANPAVTQYRWAKGGQILKEVTDETYETVVDFSFFTEPVSCEVTNALGSTNVSRTVDVYFGPRMSSE-PESITVDLGSDATFHCAWIGNPSLTIVWMKRGSGVVLSNENTLTLKNVRQEDAGKYVCRAVVPRVGAGERDISLTVNGPPIISSTQTQHALHGEKGQIKCFIRSTP--PPDRIAWSWKENVLESGTSGRYTVETVSTDEGVISTLTISNIVRADFQTIYNCTAWNSFGSDTEIIRLKEQESVPVTVIIG 485

[Close]

BLAST of NEPH-2 vs. Ensembl Xenopus
Match: rps7 (ribosomal protein S7 [Source:Xenbase;Acc:XB-GENE-977326])

HSP 1 Score: 159.458 bits (402), Expect = 9.567e-40
Identity = 132/522 (25.29%), Postives = 223/522 (42.72%), Query Frame = 3

Query:  456 HPENQRVTLNSTVTIQCRVQPIKNMKVYWVKSGFGLGETRSDIRSFGMVGNKVRYDIPNDLSAGNYDLQITDVNLEDEGDFYCQMNIKNNAITSQRAQLHVLVASGPPKIIQIGNQGMGPEKLRNENSPIVVDNGDLMALRCQAERGRPGARLTWMIDNEIIEPDLSGNFNGIISGTITNISKKIVNNTKLRDSFSTLKAKVNQLLNGKSIKCSATNRGFEKFNFPEAKAKIEIHVAPTVTMDIVSQNLGNEFSENDWITISCSALGRPDKFLWKWYINDNEVMNDNRSSYKIKATRTMNKAVVKCIANNGKEGHDL-RMLNVKYGPQFKDDSPPLYPANIGDDVTLTCNTDSNPMANIYWQRESNNDIIGHGTILYRKNIQELDFGTYICTAGVENFDLKSKKIILAKRIKPMIRENPDHRASLGRSVQAKCVIDSIPIANHNQIMWLYRGRRLINDNT-KYSISTEKYVDHSISILSINNIQASDFGQ-YNCSVTTDLGSASKVMVLSKTSPIPLILIVG 2012
             P++Q V     V++ C + P  +  + W+K G  +G  R D+  +       RY +  D  +G + L I    L+D+  + CQ      AI S+ A+L VLV    P I        GP         I +  GD + L C A+  +P A +TWM + E++        NG          K ++ + K     STL    + + NG++I C ATN+        EA   I I   P V + +  Q +     E++ +   C+A   P    ++W      +      +Y+     +     V C   N     ++ R ++V +GP+   + P     ++G D T  C    NP   I W +  +  ++ +   L  KN+++ D G Y+C A V       + I L     P+I       A  G   Q KC I S P    ++I W ++   L +  + +Y++ T    +  IS L+I+NI  +DF   YNC+     GS ++++ L +   +P+ +I+G
Sbjct:   24 QPQDQVVVAGQPVSLLCAI-PGYHGLLLWIKDGLAIGVGR-DLSGYP------RYSVGGDHLSGEHHLMIQRAELQDDAMYECQA--IQAAIRSRPARLTVLVPPDDPVITG------GPV--------ISIRAGDPLNLTCHADNAKPAATITWMKNGEVL--------NG------ATYYKTLLRDGKRESIISTLFVSSSDIENGQTITCRATNKAVPGGK--EATVTINIQHPPLVNLTVEPQPV----LEDNVVKFHCAAKANPAVTQYRWAKGGQILKEVTDETYETVVDFSFFTEPVSCEVTNALGSTNVSRTVDVYFGPRMSSE-PESITVDLGSDATFHCAWIGNPSLTIVWMKRGSGVVLSNENTLTLKNVRQEDAGKYVCRAVVPRVGAGERDISLTVNGPPIISSTQTQHALHGEKGQIKCFIRSTP--PPDRIAWSWKENVLESGTSGRYTVETVSTDEGVISTLTISNIVRADFQTIYNCTAWNSFGSDTEIIRLKEQESVPVTVIIG 498

[Close]

BLAST of NEPH-2 vs. Ensembl Mouse
Match: Kirrel3 (kirre like nephrin family adhesion molecule 3 [Source:MGI Symbol;Acc:MGI:1914953])

HSP 1 Score: 162.155 bits (409), Expect = 2.643e-41
Identity = 135/522 (25.86%), Postives = 227/522 (43.49%), Query Frame = 3

Query:  456 HPENQRVTLNSTVTIQCRVQPIKNMKVYWVKSGFGLGETRSDIRSFGMVGNKVRYDIPNDLSAGNYDLQITDVNLEDEGDFYCQMNIKNNAITSQRAQLHVLVASGPPKIIQIGNQGMGPEKLRNENSPIVVDNGDLMALRCQAERGRPGARLTWMIDNEIIEPDLSGNFNGIISGTITNISKKIVNNTKLRDSFSTLKAKVNQLLNGKSIKCSATNRGFEKFNFPEAKAKIEIHVAPTVTMDIVSQNLGNEFSENDWITISCSALGRPDKFLWKWYINDNEVMNDNRSSYKIKATRTMNKAVVKCIANNGKEGHDL-RMLNVKYGPQFKDDSPPLYPANIGDDVTLTCNTDSNPMANIYWQRESNNDIIGHGTILYRKNIQELDFGTYICTAGVENFDLKSKKIILAKRIKPMIRENPDHRASLGRSVQAKCVIDSIPIANHNQIMWLYRGRRLINDNT-KYSISTEKYVDHSISILSINNIQASDFGQ-YNCSVTTDLGSASKVMVLSKTSPIPLILIVG 2012
             P++Q V     VT+ C + P  +  V W+K G  LG  R D+ S+       +Y +  +  +G + L+I    L+D+  + CQ      AI S+ A+L VLV    P I+       GP         I +  GD + L C A+  +P A + W+   E+I        NG         SK ++ + K     STL      + NG+SI C ATN+        E    I+I   P V + +  Q +     E++ +T  CSA   P    ++W    + +   +   Y+     T     V C   N     +L R ++V +GP+   +   L   ++G D   +C    NP   I W +  +  ++ +   L  K++++ D G Y+C A V       +++ L     P+I       A  G   Q KC I S P    ++I W ++   L +  + +Y++ T    +  IS L+I+NI  +DF   YNC+     GS ++++ L +   +P+ +I+G
Sbjct:   20 QPQDQVVVSGQPVTLLCAI-PEYDGFVLWIKDGLALGVGR-DLSSYP------QYLVVGNHLSGEHHLKILRAELQDDAVYECQA--IQAAIRSRPARLTVLVPPDDPIILG------GPV--------ISLRAGDPLNLTCHADNAKPAASIIWLRKGEVI--------NG------ATYSKTLLRDGKRESIVSTLFISPGDVENGQSIVCRATNKAIPGGK--ETSVTIDIQHPPLVNLSVEPQPV----LEDNIVTFHCSAKANPAVTQYRWAKRGHIIKEASGELYRTTVDYTYFSEPVSCEVTNALGSTNLSRTVDVYFGPRMTSEPQSLL-VDLGSDAVFSCAWIGNPSLTIVWMKRGSGVVLSNEKTLTLKSVRQEDAGKYVCRAVVPRVGAGEREVTLTVNGPPIISSTQTQHALHGEKGQIKCFIRSTP--PPDRIAWSWKENVLESGTSGRYTVETVNTEEGVISTLTISNIVRADFQTIYNCTAWNSFGSDTEIIRLKEQESVPMAVIIG 494

[Close]

BLAST of NEPH-2 vs. Ensembl Mouse
Match: Kirrel3 (kirre like nephrin family adhesion molecule 3 [Source:MGI Symbol;Acc:MGI:1914953])

HSP 1 Score: 162.155 bits (409), Expect = 1.172e-40
Identity = 135/522 (25.86%), Postives = 227/522 (43.49%), Query Frame = 3

Query:  456 HPENQRVTLNSTVTIQCRVQPIKNMKVYWVKSGFGLGETRSDIRSFGMVGNKVRYDIPNDLSAGNYDLQITDVNLEDEGDFYCQMNIKNNAITSQRAQLHVLVASGPPKIIQIGNQGMGPEKLRNENSPIVVDNGDLMALRCQAERGRPGARLTWMIDNEIIEPDLSGNFNGIISGTITNISKKIVNNTKLRDSFSTLKAKVNQLLNGKSIKCSATNRGFEKFNFPEAKAKIEIHVAPTVTMDIVSQNLGNEFSENDWITISCSALGRPDKFLWKWYINDNEVMNDNRSSYKIKATRTMNKAVVKCIANNGKEGHDL-RMLNVKYGPQFKDDSPPLYPANIGDDVTLTCNTDSNPMANIYWQRESNNDIIGHGTILYRKNIQELDFGTYICTAGVENFDLKSKKIILAKRIKPMIRENPDHRASLGRSVQAKCVIDSIPIANHNQIMWLYRGRRLINDNT-KYSISTEKYVDHSISILSINNIQASDFGQ-YNCSVTTDLGSASKVMVLSKTSPIPLILIVG 2012
             P++Q V     VT+ C + P  +  V W+K G  LG  R D+ S+       +Y +  +  +G + L+I    L+D+  + CQ      AI S+ A+L VLV    P I+       GP         I +  GD + L C A+  +P A + W+   E+I        NG         SK ++ + K     STL      + NG+SI C ATN+        E    I+I   P V + +  Q +     E++ +T  CSA   P    ++W    + +   +   Y+     T     V C   N     +L R ++V +GP+   +   L   ++G D   +C    NP   I W +  +  ++ +   L  K++++ D G Y+C A V       +++ L     P+I       A  G   Q KC I S P    ++I W ++   L +  + +Y++ T    +  IS L+I+NI  +DF   YNC+     GS ++++ L +   +P+ +I+G
Sbjct:   20 QPQDQVVVSGQPVTLLCAI-PEYDGFVLWIKDGLALGVGR-DLSSYP------QYLVVGNHLSGEHHLKILRAELQDDAVYECQA--IQAAIRSRPARLTVLVPPDDPIILG------GPV--------ISLRAGDPLNLTCHADNAKPAASIIWLRKGEVI--------NG------ATYSKTLLRDGKRESIVSTLFISPGDVENGQSIVCRATNKAIPGGK--ETSVTIDIQHPPLVNLSVEPQPV----LEDNIVTFHCSAKANPAVTQYRWAKRGHIIKEASGELYRTTVDYTYFSEPVSCEVTNALGSTNLSRTVDVYFGPRMTSEPQSLL-VDLGSDAVFSCAWIGNPSLTIVWMKRGSGVVLSNEKTLTLKSVRQEDAGKYVCRAVVPRVGAGEREVTLTVNGPPIISSTQTQHALHGEKGQIKCFIRSTP--PPDRIAWSWKENVLESGTSGRYTVETVNTEEGVISTLTISNIVRADFQTIYNCTAWNSFGSDTEIIRLKEQESVPMAVIIG 494

[Close]

BLAST of NEPH-2 vs. Ensembl Mouse
Match: Kirrel3 (kirre like nephrin family adhesion molecule 3 [Source:MGI Symbol;Acc:MGI:1914953])

HSP 1 Score: 162.155 bits (409), Expect = 1.172e-40
Identity = 135/522 (25.86%), Postives = 227/522 (43.49%), Query Frame = 3

Query:  456 HPENQRVTLNSTVTIQCRVQPIKNMKVYWVKSGFGLGETRSDIRSFGMVGNKVRYDIPNDLSAGNYDLQITDVNLEDEGDFYCQMNIKNNAITSQRAQLHVLVASGPPKIIQIGNQGMGPEKLRNENSPIVVDNGDLMALRCQAERGRPGARLTWMIDNEIIEPDLSGNFNGIISGTITNISKKIVNNTKLRDSFSTLKAKVNQLLNGKSIKCSATNRGFEKFNFPEAKAKIEIHVAPTVTMDIVSQNLGNEFSENDWITISCSALGRPDKFLWKWYINDNEVMNDNRSSYKIKATRTMNKAVVKCIANNGKEGHDL-RMLNVKYGPQFKDDSPPLYPANIGDDVTLTCNTDSNPMANIYWQRESNNDIIGHGTILYRKNIQELDFGTYICTAGVENFDLKSKKIILAKRIKPMIRENPDHRASLGRSVQAKCVIDSIPIANHNQIMWLYRGRRLINDNT-KYSISTEKYVDHSISILSINNIQASDFGQ-YNCSVTTDLGSASKVMVLSKTSPIPLILIVG 2012
             P++Q V     VT+ C + P  +  V W+K G  LG  R D+ S+       +Y +  +  +G + L+I    L+D+  + CQ      AI S+ A+L VLV    P I+       GP         I +  GD + L C A+  +P A + W+   E+I        NG         SK ++ + K     STL      + NG+SI C ATN+        E    I+I   P V + +  Q +     E++ +T  CSA   P    ++W    + +   +   Y+     T     V C   N     +L R ++V +GP+   +   L   ++G D   +C    NP   I W +  +  ++ +   L  K++++ D G Y+C A V       +++ L     P+I       A  G   Q KC I S P    ++I W ++   L +  + +Y++ T    +  IS L+I+NI  +DF   YNC+     GS ++++ L +   +P+ +I+G
Sbjct:   20 QPQDQVVVSGQPVTLLCAI-PEYDGFVLWIKDGLALGVGR-DLSSYP------QYLVVGNHLSGEHHLKILRAELQDDAVYECQA--IQAAIRSRPARLTVLVPPDDPIILG------GPV--------ISLRAGDPLNLTCHADNAKPAASIIWLRKGEVI--------NG------ATYSKTLLRDGKRESIVSTLFISPGDVENGQSIVCRATNKAIPGGK--ETSVTIDIQHPPLVNLSVEPQPV----LEDNIVTFHCSAKANPAVTQYRWAKRGHIIKEASGELYRTTVDYTYFSEPVSCEVTNALGSTNLSRTVDVYFGPRMTSEPQSLL-VDLGSDAVFSCAWIGNPSLTIVWMKRGSGVVLSNEKTLTLKSVRQEDAGKYVCRAVVPRVGAGEREVTLTVNGPPIISSTQTQHALHGEKGQIKCFIRSTP--PPDRIAWSWKENVLESGTSGRYTVETVNTEEGVISTLTISNIVRADFQTIYNCTAWNSFGSDTEIIRLKEQESVPMAVIIG 494

[Close]

BLAST of NEPH-2 vs. Ensembl Mouse
Match: Kirrel3 (kirre like nephrin family adhesion molecule 3 [Source:MGI Symbol;Acc:MGI:1914953])

HSP 1 Score: 162.54 bits (410), Expect = 1.230e-40
Identity = 135/522 (25.86%), Postives = 227/522 (43.49%), Query Frame = 3

Query:  456 HPENQRVTLNSTVTIQCRVQPIKNMKVYWVKSGFGLGETRSDIRSFGMVGNKVRYDIPNDLSAGNYDLQITDVNLEDEGDFYCQMNIKNNAITSQRAQLHVLVASGPPKIIQIGNQGMGPEKLRNENSPIVVDNGDLMALRCQAERGRPGARLTWMIDNEIIEPDLSGNFNGIISGTITNISKKIVNNTKLRDSFSTLKAKVNQLLNGKSIKCSATNRGFEKFNFPEAKAKIEIHVAPTVTMDIVSQNLGNEFSENDWITISCSALGRPDKFLWKWYINDNEVMNDNRSSYKIKATRTMNKAVVKCIANNGKEGHDL-RMLNVKYGPQFKDDSPPLYPANIGDDVTLTCNTDSNPMANIYWQRESNNDIIGHGTILYRKNIQELDFGTYICTAGVENFDLKSKKIILAKRIKPMIRENPDHRASLGRSVQAKCVIDSIPIANHNQIMWLYRGRRLINDNT-KYSISTEKYVDHSISILSINNIQASDFGQ-YNCSVTTDLGSASKVMVLSKTSPIPLILIVG 2012
             P++Q V     VT+ C + P  +  V W+K G  LG  R D+ S+       +Y +  +  +G + L+I    L+D+  + CQ      AI S+ A+L VLV    P I+       GP         I +  GD + L C A+  +P A + W+   E+I        NG         SK ++ + K     STL      + NG+SI C ATN+        E    I+I   P V + +  Q +     E++ +T  CSA   P    ++W    + +   +   Y+     T     V C   N     +L R ++V +GP+   +   L   ++G D   +C    NP   I W +  +  ++ +   L  K++++ D G Y+C A V       +++ L     P+I       A  G   Q KC I S P    ++I W ++   L +  + +Y++ T    +  IS L+I+NI  +DF   YNC+     GS ++++ L +   +P+ +I+G
Sbjct:   53 QPQDQVVVSGQPVTLLCAI-PEYDGFVLWIKDGLALGVGR-DLSSYP------QYLVVGNHLSGEHHLKILRAELQDDAVYECQA--IQAAIRSRPARLTVLVPPDDPIILG------GPV--------ISLRAGDPLNLTCHADNAKPAASIIWLRKGEVI--------NG------ATYSKTLLRDGKRESIVSTLFISPGDVENGQSIVCRATNKAIPGGK--ETSVTIDIQHPPLVNLSVEPQPV----LEDNIVTFHCSAKANPAVTQYRWAKRGHIIKEASGELYRTTVDYTYFSEPVSCEVTNALGSTNLSRTVDVYFGPRMTSEPQSLL-VDLGSDAVFSCAWIGNPSLTIVWMKRGSGVVLSNEKTLTLKSVRQEDAGKYVCRAVVPRVGAGEREVTLTVNGPPIISSTQTQHALHGEKGQIKCFIRSTP--PPDRIAWSWKENVLESGTSGRYTVETVNTEEGVISTLTISNIVRADFQTIYNCTAWNSFGSDTEIIRLKEQESVPMAVIIG 527

[Close]

BLAST of NEPH-2 vs. Ensembl Mouse
Match: Kirrel (kirre like nephrin family adhesion molecule 1 [Source:MGI Symbol;Acc:MGI:1891396])

HSP 1 Score: 156.377 bits (394), Expect = 1.365e-38
Identity = 128/536 (23.88%), Postives = 225/536 (41.98%), Query Frame = 3

Query:  432 GNENYINVHPENQRVTLNSTVTIQCRVQPIKNMKVYWVKSGFGLGETRSDIRSFGMVGNKVRYDIPNDLSAGNYDLQITDVNLEDEGDFYCQMNIKNNAITSQRAQLHVLVASGPPKIIQIGNQGMGPEKLRNENSPIVV-DNGDLMALRCQAERGRPGARLTWMIDNEIIEPDLSGNFNGIISGTITNISKKIVNNTKLRDSFSTLKAKVNQLLNGKSIKCSATNRGFEKFNFPEAKAKIEIHVAPTVTMDIVSQNLGNEFSENDWITISCSALGRPDKFLWKWYINDNEVMNDNRSSYKIKATRTMNKAVVKCIANNGKEGHDLRML-NVKYGPQFKDDSPPLYP----ANIGDDVTLTCNTDSNPMANIYWQRESNNDIIGHGTILYRKNIQELDFGTYICTAGVENFDLKSKKIILAKRIKPMIRENPDHRASLGRSVQAKCVIDSIPIANHNQIMWLYRGRRL-INDNTKYSISTEKYVDHSISILSINNIQASDF-GQYNCSVTTDLGSASKVMVLSKTSPIPLILIVGG 2015
            G +   +  P +Q V       + C +     + V W K G  LG  +  ++++       RY +     AG Y+L+ITD  L D+  + CQ      A+ S+RA+L VL+                PE+ R +  P+++   G    L C+A   +P A + W  D    E            G +T  S +++ + K   + S L  +   L  G+   C + N      N  E   ++++H  PTVT+ I  Q +     E + +  +C A   P+   ++W      + + + S Y+     +     V C   N     ++  L NV + P+       +YP     +IG DVTLTC    NP   + W ++ +N ++ +   L  K++ + D GTY C A V    +  +++ L     P+I       A  G   + +C I S P    ++I W ++   L +    +Y++         +S L+INN+  +DF   YNC+     G  + ++ L +   +P+ +I G 
Sbjct:   50 GTQTRFSQEPADQTVVAGQRAVLPCVLLNYSGI-VQWTKDGLALGMGQG-LKAWP------RYRVVGSADAGQYNLEITDAELSDDASYECQAT--EAALRSRRAKLTVLIP---------------PEETRIDGGPVILLQAGTPYNLTCRAFNAKPAATIIWFRDGTQQE------------GAVT--STELLKDGKRETTISQLLIEPTDLDIGRVFTCRSMNEAIP--NGKETSIELDVHHPPTVTLSIEPQTV----LEGERVIFTCQATANPEILGYRWAKGGFLIEDAHESRYETNVDYSFFTEPVSCEVYNKVGSTNVSTLVNVHFAPRIV-----VYPKPTTTDIGSDVTLTCVWVGNPPLTLTWTKKDSNMVLSNSNQLLLKSVTQADAGTYTCRAIVPRIGVAEREVPLYVNGPPIISSEAVQFAVRGDGGKVECFIGSTP--PPDRIAWAWKENFLEVGTLERYTVERTNSGSGVLSTLTINNVMEADFQTHYNCTAWNSFGPGTAIIQLEEREVLPVGIIAGA 533

[Close]

BLAST of NEPH-2 vs. UniProt/SwissProt
Match: sp|Q08180|ICCR_DROME (Irregular chiasm C-roughest protein OS=Drosophila melanogaster OX=7227 GN=rst PE=1 SV=2)

HSP 1 Score: 168.318 bits (425), Expect = 1.284e-41
Identity = 140/551 (25.41%), Postives = 239/551 (43.38%), Query Frame = 3

Query:  453 VHPENQRVTLNSTVTIQCRVQPIKNMKVYWVKSGFGLGETR--SDIRSFGMVGNKVRYDIPNDLSAGNYDLQITDVNLEDEGDFYCQMNIK---NNAITSQRAQLHVLVASGPPKIIQIGNQGMGPEKLRNENSPIVVDNGDLMALRCQAERGRPGARLTWMIDNEIIEPDLSGNFNGIISGTITNISKKIVNNTKLR--DSFSTLKAKVNQLLNGKSIKCSATNRGFEKFNFPEAKAKIEIHVAPTVTMDIVSQ-------------------NLGNEFSENDWITISCSALGRPDKFLWKWYINDNEVMNDNRSSYKIK-ATRTMNKAVVKC-IANNGKEGHDLRMLNVKYGPQFKDDSPPLYPANIGDDVTLTCNTDSNPMANIYWQRESNNDIIGHGTILYRKNIQELDFGTYICTAGVENFDLKSKKIILAKRIKPMIRENPDHRASLGRSVQAKCVIDSIPIANHNQIMWLYRGRRLINDNTK-YSISTEKYVDHSISILSINNIQASDFGQYNCSVTTDLGS-ASKVMVLSKTSPIPLILIVGG 2015
            + P++Q   + + VT+ CRV   K   + W K  FGLG +R  S    + MVG+            G+Y L I  V L+D+  + CQ++       AI S  A L VLV    PKI Q G+     E  + E             + C +  G+P A +TW+              +G+ +    NI   ++     R   + S L+    +  +  +  C A N     +    AK ++E+  AP V ++++                     + G+   E+  + + C A   P    ++W+IND  ++   ++   I+  TR  + A+VKC + N+  +  D   L++ Y P F+   P    A++G  V+LTC  DSNP   I W +  ++ ++G  T L   ++     G Y C A V  +   S    +  +  P I         +G + + +C   S+P A H  + W + G+ + +++   YSI  +       S L I + QA  +G+YNC+V  D G+  +++ + +K S   L+ IVGG
Sbjct:   32 MEPQDQTAVVGARVTLPCRVIN-KQGTLQWTKDDFGLGTSRDLSGFERYAMVGSD---------EEGDYSLDIYPVMLDDDARYQCQVSPGPEGQPAIRSTFAGLTVLVPPEAPKITQ-GDVIYATEDRKVE-------------IECVSVGGKPAAEITWI--------------DGLGNVLTDNIEYTVIPLPDQRRFTAKSVLRLTPKKEHHNTNFSCQAQNTADRTYR--SAKIRVEVKYAPKVKVNVMGSLPGGAGGSVGGAGGGSVHMSTGSRIVEHSQVRLECRADANPSDVRYRWFINDEPIIGGQKTEMVIRNVTRKFHDAIVKCEVQNSVGKSEDSETLDISYAPSFRQ-RPQSMEADVGSVVSLTCEVDSNPQPEIVWIQHPSDRVVGTSTNL-TFSVSNETAGRYYCKANVPGYAEISADAYVYLKGSPAIGSQRTQYGLVGDTARIECFASSVPRARH--VSWTFNGQEISSESGHDYSILVDAVPGGVKSTLIIRDSQAYHYGKYNCTVVNDYGNDVAEIQLQAKKSVSLLMTIVGG 538

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BLAST of NEPH-2 vs. UniProt/SwissProt
Match: sp|Q96J84|KIRR1_HUMAN (Kin of IRRE-like protein 1 OS=Homo sapiens OX=9606 GN=KIRREL1 PE=1 SV=2)

HSP 1 Score: 156.377 bits (394), Expect = 6.950e-38
Identity = 126/532 (23.68%), Postives = 222/532 (41.73%), Query Frame = 3

Query:  432 GNENYINVHPENQRVTLNSTVTIQCRVQPIKNMKVYWVKSGFGLGETRSDIRSFGMVGNKVRYDIPNDLSAGNYDLQITDVNLEDEGDFYCQMNIKNNAITSQRAQLHVLVASGPPKIIQIGNQGMGPEKLRNENSPIVV-DNGDLMALRCQAERGRPGARLTWMIDNEIIEPDLSGNFNGIISGTITNISKKIVNNTKLRDSFSTLKAKVNQLLNGKSIKCSATNRGFEKFNFPEAKAKIEIHVAPTVTMDIVSQNLGNEFSENDWITISCSALGRPDKFLWKWYINDNEVMNDNRSSYKIKATRTMNKAVVKCIANNGKEGHDLRML-NVKYGPQFKDDSPPLYPANIGDDVTLTCNTDSNPMANIYWQRESNNDIIGHGTILYRKNIQELDFGTYICTAGVENFDLKSKKIILAKRIKPMIRENPDHRASLGRSVQAKCVIDSIPIANHNQIMWLYRGRRL-INDNTKYSISTEKYVDHSISILSINNIQASDF-GQYNCSVTTDLGSASKVMVLSKTSPIPLILIVGG 2015
            G +   +  P +Q V       + C +     + V W K G  LG  +  ++++       RY +     AG Y+L+ITD  L D+  + CQ      A+ S+RA+L VL+                PE  R +  P+++   G    L C+A   +P A + W  D    E        G ++ T      +++ + K   + S L      L  G+   C + N         E   ++++H  PTVT+ I  Q +     E + +  +C A   P+   ++W      + + + S Y+     +     V C  +N     ++  L NV + P+   D  P    +IG DVTLTC    NP   + W ++ +N ++ +   L  K++ + D GTY C A V    +  +++ L     P+I       A  G   + +C I S P    ++I W ++   L +    +Y++         +S L+INN+  +DF   YNC+     G  + ++ L +   +P+ +I G 
Sbjct:   18 GTQTRFSQEPADQTVVAGQRAVLPCVLLNYSGI-VQWTKDGLALGMGQG-LKAWP------RYRVVGSADAGQYNLEITDAELSDDASYECQAT--EAALRSRRAKLTVLIP---------------PEDTRIDGGPVILLQAGTPHNLTCRAFNAKPAATIIWFRDGTQQE--------GAVAST------ELLKDGKRETTVSQLLINPTDLDIGRVFTCRSMNEAIPSGK--ETSIELDVHHPPTVTLSIEPQTV----QEGERVVFTCQATANPEILGYRWAKGGFLIEDAHESRYETNVDYSFFTEPVSCEVHNKVGSTNVSTLVNVHFAPRIVVDPKPT-TTDIGSDVTLTCVWVGNPPLTLTWTKKDSNMVLSNSNQLLLKSVTQADAGTYTCRAIVPRIGVAEREVPLYVNGPPIISSEAVQYAVRGDGGKVECFIGSTPPP--DRIAWAWKENFLEVGTLERYTVERTNSGSGVLSTLTINNVMEADFQTHYNCTAWNSFGPGTAIIQLEEREVLPVGIIAGA 501

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BLAST of NEPH-2 vs. UniProt/SwissProt
Match: sp|Q80W68|KIRR1_MOUSE (Kin of IRRE-like protein 1 OS=Mus musculus OX=10090 GN=Kirrel1 PE=1 SV=1)

HSP 1 Score: 156.377 bits (394), Expect = 9.548e-38
Identity = 128/536 (23.88%), Postives = 225/536 (41.98%), Query Frame = 3

Query:  432 GNENYINVHPENQRVTLNSTVTIQCRVQPIKNMKVYWVKSGFGLGETRSDIRSFGMVGNKVRYDIPNDLSAGNYDLQITDVNLEDEGDFYCQMNIKNNAITSQRAQLHVLVASGPPKIIQIGNQGMGPEKLRNENSPIVV-DNGDLMALRCQAERGRPGARLTWMIDNEIIEPDLSGNFNGIISGTITNISKKIVNNTKLRDSFSTLKAKVNQLLNGKSIKCSATNRGFEKFNFPEAKAKIEIHVAPTVTMDIVSQNLGNEFSENDWITISCSALGRPDKFLWKWYINDNEVMNDNRSSYKIKATRTMNKAVVKCIANNGKEGHDLRML-NVKYGPQFKDDSPPLYP----ANIGDDVTLTCNTDSNPMANIYWQRESNNDIIGHGTILYRKNIQELDFGTYICTAGVENFDLKSKKIILAKRIKPMIRENPDHRASLGRSVQAKCVIDSIPIANHNQIMWLYRGRRL-INDNTKYSISTEKYVDHSISILSINNIQASDF-GQYNCSVTTDLGSASKVMVLSKTSPIPLILIVGG 2015
            G +   +  P +Q V       + C +     + V W K G  LG  +  ++++       RY +     AG Y+L+ITD  L D+  + CQ      A+ S+RA+L VL+                PE+ R +  P+++   G    L C+A   +P A + W  D    E            G +T  S +++ + K   + S L  +   L  G+   C + N      N  E   ++++H  PTVT+ I  Q +     E + +  +C A   P+   ++W      + + + S Y+     +     V C   N     ++  L NV + P+       +YP     +IG DVTLTC    NP   + W ++ +N ++ +   L  K++ + D GTY C A V    +  +++ L     P+I       A  G   + +C I S P    ++I W ++   L +    +Y++         +S L+INN+  +DF   YNC+     G  + ++ L +   +P+ +I G 
Sbjct:   50 GTQTRFSQEPADQTVVAGQRAVLPCVLLNYSGI-VQWTKDGLALGMGQG-LKAWP------RYRVVGSADAGQYNLEITDAELSDDASYECQAT--EAALRSRRAKLTVLIP---------------PEETRIDGGPVILLQAGTPYNLTCRAFNAKPAATIIWFRDGTQQE------------GAVT--STELLKDGKRETTISQLLIEPTDLDIGRVFTCRSMNEAIP--NGKETSIELDVHHPPTVTLSIEPQTV----LEGERVIFTCQATANPEILGYRWAKGGFLIEDAHESRYETNVDYSFFTEPVSCEVYNKVGSTNVSTLVNVHFAPRIV-----VYPKPTTTDIGSDVTLTCVWVGNPPLTLTWTKKDSNMVLSNSNQLLLKSVTQADAGTYTCRAIVPRIGVAEREVPLYVNGPPIISSEAVQFAVRGDGGKVECFIGSTP--PPDRIAWAWKENFLEVGTLERYTVERTNSGSGVLSTLTINNVMEADFQTHYNCTAWNSFGPGTAIIQLEEREVLPVGIIAGA 533

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BLAST of NEPH-2 vs. UniProt/SwissProt
Match: sp|Q6X936|KIRR1_RAT (Kin of IRRE-like protein 1 OS=Rattus norvegicus OX=10116 GN=Kirrel1 PE=1 SV=2)

HSP 1 Score: 155.992 bits (393), Expect = 1.290e-37
Identity = 128/536 (23.88%), Postives = 224/536 (41.79%), Query Frame = 3

Query:  432 GNENYINVHPENQRVTLNSTVTIQCRVQPIKNMKVYWVKSGFGLGETRSDIRSFGMVGNKVRYDIPNDLSAGNYDLQITDVNLEDEGDFYCQMNIKNNAITSQRAQLHVLVASGPPKIIQIGNQGMGPEKLRNENSPIVV-DNGDLMALRCQAERGRPGARLTWMIDNEIIEPDLSGNFNGIISGTITNISKKIVNNTKLRDSFSTLKAKVNQLLNGKSIKCSATNRGFEKFNFPEAKAKIEIHVAPTVTMDIVSQNLGNEFSENDWITISCSALGRPDKFLWKWYINDNEVMNDNRSSYKIKATRTMNKAVVKCIANNGKEGHDLRML-NVKYGPQFKDDSPPLYP----ANIGDDVTLTCNTDSNPMANIYWQRESNNDIIGHGTILYRKNIQELDFGTYICTAGVENFDLKSKKIILAKRIKPMIRENPDHRASLGRSVQAKCVIDSIPIANHNQIMWLYRGRRL-INDNTKYSISTEKYVDHSISILSINNIQASDF-GQYNCSVTTDLGSASKVMVLSKTSPIPLILIVGG 2015
            G +   +  P +Q V       + C +     + V W K G  LG  +  ++++       RY +     AG Y+L+ITD  L D+  + CQ      A+ S+RA+L VL+                PE  R +  P+++   G    L C+A   +P A + W  D    E            G +T  S +++ + K   + S L  +   L  G+   C + N      N  E   ++++H  PTVT+ I  Q +     E + +  +C A   P+   ++W      + + + S Y+     +     V C   N     ++  L NV + P+       +YP     +IG DVTLTC    NP   + W ++ +N ++ +   L  K++ + D GTY C A V    +  +++ L     P+I       A  G   + +C I S P    ++I W ++   L +    +Y++         +S L+INN+  +DF   YNC+     G  + ++ L +   +P+ +I G 
Sbjct:   50 GTQTRFSQEPADQTVVAGHRAVLPCVLLNYSGI-VQWTKDGLALGMGQG-LKAWP------RYRVVGSADAGQYNLEITDAELSDDASYECQAT--EAALRSRRAKLTVLIP---------------PEDTRIDGGPVILLQAGTPYNLTCRAFNAKPAATIIWFRDGTQQE------------GAVT--STELLKDGKRETTISQLLIQPTDLDIGRVFTCRSMNEAIP--NGKETSIELDVHHPPTVTLSIEPQTV----LEGERVIFTCQATANPEILGYRWAKGGFLIEDAHESRYETNVDYSFFTEPVSCEVYNKVGSTNVSTLVNVHFAPRIV-----VYPKPTTTDIGSDVTLTCVWVGNPPLTLTWTKKDSNMVLSNSNQLLLKSVTQADAGTYTCRAIVPRIGVAEREVPLYVNGPPIISSEAVQFAVRGDGGKVECFIGSTPPP--DRIAWAWKENFLEVGTLERYTVERTNSGSGVLSTLTINNVMEADFQTHYNCTAWNSFGPGTAIIQLEEREVLPVGIIAGA 533

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BLAST of NEPH-2 vs. UniProt/SwissProt
Match: sp|Q8IZU9|KIRR3_HUMAN (Kin of IRRE-like protein 3 OS=Homo sapiens OX=9606 GN=KIRREL3 PE=1 SV=1)

HSP 1 Score: 154.451 bits (389), Expect = 3.673e-37
Identity = 135/534 (25.28%), Postives = 226/534 (42.32%), Query Frame = 3

Query:  456 HPENQRVTLNSTVTIQCRVQPIKNMKVYWVKSGFGLGETRSDIRSFGMVGNKVRYDIPNDLSAGNYDLQITDVNLEDEGDFYCQMNIKNNAITSQRAQLHVLVASGPPKIIQIGNQGMGPEKLRNENSPIVVDNGDLMALRCQAERGRPGARLTWMIDNEIIEPDLSGNFNGIISGTITNISKKIVNNTKLRDSFSTLKAKVNQLLNGKSIKCSATNRGFEKFNFPEAKAKIEIHVAPTVTMDIVSQNLGNEFSENDWITISCSALGRPDKFLWKWYINDNEVMNDNRSSYKIKATRTMNKAVVKCIANNGKEGHDL-RMLNVKYGPQFKDDSPPLYPANIGDDVTLTCNTDSNPMANIYWQRESNNDIIGHGTILYRKNIQELDFGTYICTAGVENFDLKSKKIILAKRIKPMIRENPDHRASLGRSVQAKCVIDSIPIANHNQIMWLYRGRRLINDNT-KYSISTEKYVDHSISILSINNIQASDFGQ-YNCSVTTDLGSASKVMVLS------------KTSPIPLILIVG 2012
             P++Q V     VT+ C + P  +  V W+K G  LG  R D+ S+       +Y +  +  +G + L+I    L+D+  + CQ      AI S+ A+L VLV    P I+       GP         I +  GD + L C A+  +P A + W+   E+I        NG         SK ++ + K     STL      + NG+SI C ATN+        E    I+I   P V + +  Q +     E++ +T  CSA   P    ++W      +   +   Y+     T     V C   N     +L R ++V +GP+   +   L   ++G D   +C    NP   I W +  +  ++ +   L  K++++ D G Y+C A V       +++ L     P+I       A  G   Q KC I S P    ++I W ++   L +  + +Y++ T    +  IS L+I+NI  +DF   YNC+     GS ++++ L             +   +P+ +I+G
Sbjct:   53 QPQDQVVVSGQPVTLLCAI-PEYDGFVLWIKDGLALGVGR-DLSSYP------QYLVVGNHLSGEHHLKILRAELQDDAVYECQA--IQAAIRSRPARLTVLVPPDDPVILG------GPV--------ISLRAGDPLNLTCHADNAKPAASIIWLRKGEVI--------NG------ATYSKTLLRDGKRESIVSTLFISPGDVENGQSIVCRATNKAIPGGK--ETSVTIDIQHPPLVNLSVEPQPV----LEDNVVTFHCSAKANPAVTQYRWAKRGQIIKEASGEVYRTTVDYTYFSEPVSCEVTNALGSTNLSRTVDVYFGPRMTTEPQSLL-VDLGSDAIFSCAWTGNPSLTIVWMKRGSGVVLSNEKTLTLKSVRQEDAGKYVCRAVVPRVGAGEREVTLTVNGPPIISSTQTQHALHGEKGQIKCFIRSTP--PPDRIAWSWKENVLESGTSGRYTVETISTEEGVISTLTISNIVRADFQTIYNCTAWNSFGSDTEIIRLKEQGSEMKSGAGLEAESVPMAVIIG 539

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BLAST of NEPH-2 vs. TrEMBL
Match: A0A0H3YFE9 (NEPH-2 OS=Schmidtea mediterranea OX=79327 GN=NEPH-2 PE=2 SV=1)

HSP 1 Score: 1707.58 bits (4421), Expect = 0.000e+0
Identity = 842/842 (100.00%), Postives = 842/842 (100.00%), Query Frame = 3

Query:  432 GNENYINVHPENQRVTLNSTVTIQCRVQPIKNMKVYWVKSGFGLGETRSDIRSFGMVGNKVRYDIPNDLSAGNYDLQITDVNLEDEGDFYCQMNIKNNAITSQRAQLHVLVASGPPKIIQIGNQGMGPEKLRNENSPIVVDNGDLMALRCQAERGRPGARLTWMIDNEIIEPDLSGNFNGIISGTITNISKKIVNNTKLRDSFSTLKAKVNQLLNGKSIKCSATNRGFEKFNFPEAKAKIEIHVAPTVTMDIVSQNLGNEFSENDWITISCSALGRPDKFLWKWYINDNEVMNDNRSSYKIKATRTMNKAVVKCIANNGKEGHDLRMLNVKYGPQFKDDSPPLYPANIGDDVTLTCNTDSNPMANIYWQRESNNDIIGHGTILYRKNIQELDFGTYICTAGVENFDLKSKKIILAKRIKPMIRENPDHRASLGRSVQAKCVIDSIPIANHNQIMWLYRGRRLINDNTKYSISTEKYVDHSISILSINNIQASDFGQYNCSVTTDLGSASKVMVLSKTSPIPLILIVGGXXXXXXXXXXXXXALCVCKRGICSNKYQKGSPTNRINSNNSTDPLKSPQFEMDYQCQPNFFQWIPNNNREQVKSSFVRYGQDVDDRSSIRNGSINQYRGLDMCSTYTSSIPGSQNGEKPIRNPDIDDVYKEEFYPSSNPAMMCSMHITPTGSGAINRASPCNAHPYSVPQHQISLPQYNFTSFANPPYLSNYLPGSNNNFALPSYPVHSPSSEPGINGGSGLMIPPVLPPIDTNDANHNVELGLSPQQTSFIKPGMTISQNMANYLSPNIRPKPNSYNYTLSGNSNDGNSFKSRTLDRRGPISSFTNVDQTTNI 2957
            GNENYINVHPENQRVTLNSTVTIQCRVQPIKNMKVYWVKSGFGLGETRSDIRSFGMVGNKVRYDIPNDLSAGNYDLQITDVNLEDEGDFYCQMNIKNNAITSQRAQLHVLVASGPPKIIQIGNQGMGPEKLRNENSPIVVDNGDLMALRCQAERGRPGARLTWMIDNEIIEPDLSGNFNGIISGTITNISKKIVNNTKLRDSFSTLKAKVNQLLNGKSIKCSATNRGFEKFNFPEAKAKIEIHVAPTVTMDIVSQNLGNEFSENDWITISCSALGRPDKFLWKWYINDNEVMNDNRSSYKIKATRTMNKAVVKCIANNGKEGHDLRMLNVKYGPQFKDDSPPLYPANIGDDVTLTCNTDSNPMANIYWQRESNNDIIGHGTILYRKNIQELDFGTYICTAGVENFDLKSKKIILAKRIKPMIRENPDHRASLGRSVQAKCVIDSIPIANHNQIMWLYRGRRLINDNTKYSISTEKYVDHSISILSINNIQASDFGQYNCSVTTDLGSASKVMVLSKTSPIPLILIVGGTVFITMVMMIVIIALCVCKRGICSNKYQKGSPTNRINSNNSTDPLKSPQFEMDYQCQPNFFQWIPNNNREQVKSSFVRYGQDVDDRSSIRNGSINQYRGLDMCSTYTSSIPGSQNGEKPIRNPDIDDVYKEEFYPSSNPAMMCSMHITPTGSGAINRASPCNAHPYSVPQHQISLPQYNFTSFANPPYLSNYLPGSNNNFALPSYPVHSPSSEPGINGGSGLMIPPVLPPIDTNDANHNVELGLSPQQTSFIKPGMTISQNMANYLSPNIRPKPNSYNYTLSGNSNDGNSFKSRTLDRRGPISSFTNVDQTTNI
Sbjct:   17 GNENYINVHPENQRVTLNSTVTIQCRVQPIKNMKVYWVKSGFGLGETRSDIRSFGMVGNKVRYDIPNDLSAGNYDLQITDVNLEDEGDFYCQMNIKNNAITSQRAQLHVLVASGPPKIIQIGNQGMGPEKLRNENSPIVVDNGDLMALRCQAERGRPGARLTWMIDNEIIEPDLSGNFNGIISGTITNISKKIVNNTKLRDSFSTLKAKVNQLLNGKSIKCSATNRGFEKFNFPEAKAKIEIHVAPTVTMDIVSQNLGNEFSENDWITISCSALGRPDKFLWKWYINDNEVMNDNRSSYKIKATRTMNKAVVKCIANNGKEGHDLRMLNVKYGPQFKDDSPPLYPANIGDDVTLTCNTDSNPMANIYWQRESNNDIIGHGTILYRKNIQELDFGTYICTAGVENFDLKSKKIILAKRIKPMIRENPDHRASLGRSVQAKCVIDSIPIANHNQIMWLYRGRRLINDNTKYSISTEKYVDHSISILSINNIQASDFGQYNCSVTTDLGSASKVMVLSKTSPIPLILIVGGTVFITMVMMIVIIALCVCKRGICSNKYQKGSPTNRINSNNSTDPLKSPQFEMDYQCQPNFFQWIPNNNREQVKSSFVRYGQDVDDRSSIRNGSINQYRGLDMCSTYTSSIPGSQNGEKPIRNPDIDDVYKEEFYPSSNPAMMCSMHITPTGSGAINRASPCNAHPYSVPQHQISLPQYNFTSFANPPYLSNYLPGSNNNFALPSYPVHSPSSEPGINGGSGLMIPPVLPPIDTNDANHNVELGLSPQQTSFIKPGMTISQNMANYLSPNIRPKPNSYNYTLSGNSNDGNSFKSRTLDRRGPISSFTNVDQTTNI 858

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BLAST of NEPH-2 vs. TrEMBL
Match: A0A4E0S4A9 (Irregular chiasm C-roughest protein OS=Fasciola hepatica OX=6192 GN=D915_000115 PE=4 SV=1)

HSP 1 Score: 466.077 bits (1198), Expect = 3.634e-145
Identity = 248/652 (38.04%), Postives = 382/652 (58.59%), Query Frame = 3

Query:  447 INVHPENQRVTLNSTVTIQCRVQPI------KNMKVYWVKSGFGLGETRSDIRSFGMVG--NKVRYDIPNDLSAGNYDLQITDVNLEDEGDFYCQMNIKNNAITSQRAQLHVLVASGPPKIIQIGNQGMGPEKLRNENSPIVVDNGDLMALRCQAERGRPGARLTWMIDNE--IIEPDLSGNFNGIISGTITNISKKIVNNTK---LRDSFSTLKAKVNQLLNGKSIKCSATNRGFEKFNFPEAKAKIEIHVAPTVTMDIVSQNLGNEFSENDWITISCSALGRPDKFLWKWYINDNEVMNDNRSSYKIKATRTMNKAVVKCIANNGKEGHDLRMLNVKYGPQFKDDSPPLYPANIGDDVTLTCNTDSNPMANIYWQRESNNDIIGHGTILYRKNIQELDFGTYICTAGVENFDLKSKKIILAKRIKPMIRENPDHRASLGRSVQAKCVIDSIPIANHNQIMWLYRGRRLINDNTKYSISTEKYVDHSISILSINNIQASDFGQYNCSVTTDLGSASKVMVLSKTSPIPLILIVGGXXXXXXXXXXXXXALCVCKRGICSNKYQKG--SPTNRINSNNSTDP-----------LKSPQFEMDYQCQPNFFQWIPNNNREQVKSSFVRYGQDVDDRSSIRNGSINQYRGLDMC 2324
            I +HPE+Q VTLNSTV +QCRV+ +         +VYW K+ FG+G  R DI+ +G        RYD+P +L  G YDLQI +V L DEG + CQ+N       SQ A L V V S  PK+IQI  +G GPE     ++P VV++G ++AL+C A  G+PGA LTW+ID    I+EP   G      SG + N++ ++  ++K   L D+ S + A++N+L +GK I+C A N G+E      A  K+E+H AP V++ I  Q   NE+ E+D IT+ C+A GRPD F W+W++N  +V N     Y+++ TR M+ AV +CIA + ++GH   ++ VK+GPQF++ S  L+ A+ G+DV ++C    NP   I W+RES ++++  G    + N++E DFGTY+CTA V+ F   SK++ +AKR  P I+ NP   A LGR  + +C ++S+P+    Q  W Y GR  I  +++++   E+++   + IL I ++  +D+G+YNC+V    G+  K++ L     IPL  I+G  V + +++++ II LCVC++ IC  KY+KG  +PT  I  + S  P            K P    D   + +++ W  NN    ++ +FVR G D+D++ S+ N S    +G D C
Sbjct:   45 IQLHPESQAVTLNSTVRLQCRVRILVDPTTGAGAQVYWSKNDFGIGGNRDDIQEYGRSARYKYSRYDLPYNLKDGQYDLQIINVELSDEGSYVCQVNFMKQQYLSQTAVLTVQVPSEAPKLIQITKEGKGPEVEVGASTPAVVEDGAILALKCVARHGKPGALLTWLIDGVPVIVEPGGDGQNGTFRSGFVGNLTVQVTPSSKFPRLMDATSQMSARLNKLHHGKLIECRAENVGYESHALRPAYTKLEVHYAPVVSIQIRPQRRNNEYMEHDVITVECTAHGRPDSFFWEWFVNGRQVENLVDPWYRLRLTRNMHNAVFRCIAISNRKGHAEMIVRVKFGPQFQEPSALLFTASPGEDVAMSCPARGNPEPRIDWRRESGHEVLHRGVTYRKDNLREEDFGTYVCTAYVQEFPPISKQMYIAKRRPPTIQPNPLVPARLGRPARLRCTVNSVPLPPMGQTHWFYNGRP-IRPDSQHTFEREEFIGGVVLILHIAHVMMTDYGKYNCTVQNGYGTDWKLIELVHQEDIPLQFIIGAAVAVGILLVVGIILLCVCRQRICGRKYKKGRPTPTQSIQGSKSNQPSLQDYGVVNTEFKVPPNGHDGTQRQSYYPWFTNN--AHLQGTFVRCGSDMDEQRSVHNSS---KQGQDKC 690

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BLAST of NEPH-2 vs. TrEMBL
Match: A0A4S2MJS2 (Uncharacterized protein OS=Opisthorchis felineus OX=147828 GN=CRM22_000877 PE=4 SV=1)

HSP 1 Score: 439.499 bits (1129), Expect = 1.415e-135
Identity = 231/647 (35.70%), Postives = 375/647 (57.96%), Query Frame = 3

Query:  432 GNENYINVHPENQRVTLNSTVTIQCRVQPIKN------MKVYWVKSGFGLGETRSDIRSFGMVGNK--VRYDIPNDLSAGNYDLQITDVNLEDEGDFYCQMNIKNNAITSQRAQLHVLVASGPPKIIQIGNQGMGPEKLRNENSPIVVDNGDLMALRCQAERGRPGARLTWMIDNEIIEPDLS-----GNFNGIISGTITNISKKIVNNTKLRDSFSTLKAKVNQLLNGKSIKCSATNRGFEKFNFPEAKAKIEIHVAPTVTMDIVSQNLGNEFSENDWITISCSALGRPDKFLWKWYINDNEVMNDNRSSYKIKATRTMNKAVVKCIANNGKEGHDLRMLNVKYGPQFKDDSPPLYPANIGDDVTLTCNTDSNPMANIYWQRESNNDIIGHGTILYRKNIQELDFGTYICTAGVENFDLKSKKIILAKRIKPMIRENPDHRASLGRSVQAKCVIDSIPIANHNQIMWLYRGRRLINDNTKYSISTEKYVDHSISILSINNIQASDFGQYNCSVTTDLGSASKVMVLSKTSPIPLILIVGGXXXXXXXXXXXXXALCVCKRGICSNKYQKGSPTNRINSNNSTDPLKSP---------QFEMDYQCQPNFFQ-----WIPNNNREQVKSSFVRYGQDVDDRSSIRNG 2291
            G +  I +HP++Q VTLNSTV +QCRV+ + +       +VYW K+ FG+G +R DI+ +G        RYD+P +L  G YDLQIT+V L DEG + CQ+N   +   SQ A L V V S  PK+ Q+ N+G GPE      +P +VD+G ++ L+C A  G+PGA ++W ID   I+ +         F    +G +TN      +  +L+D+ S + A++N+L +GK ++C ATN G+++     A  K+E+H AP V++ +      NE+ E+D IT+ C+A GRPD F+W+W++N  +V N     Y+++ TR M+ AV +CIA + K+GH    + VK+GPQF + SP L+ A++G+D+ + C    NP   I W+RE  ++++  G    + ++++ DFGTYICTA V  F   SK++ ++KR  P I+ NP   A LGR+ + +C ++S+P    +Q  W + GR +  DN  ++   E+++   + IL I ++  +D+G+YNC+V    GS  K++ LS+   IPL  IVG  + + +++++ +I LC C++ IC  KY KG      NS+ S  P+++P         +F+     Q   ++     W PN    Q ++S++  G D D++ S+  G
Sbjct:   10 GVDGIIQIHPDSQAVTLNSTVRLQCRVRILTDPQTGAGAQVYWSKNDFGIGGSREDIQEYGRSSRYPYSRYDLPYNLKDGQYDLQITNVELSDEGSYVCQVNFMKHQYLSQTALLTVQVPSEAPKLYQVTNEGKGPEVEIGSATPAIVDDGAILVLKCVARHGKPGAIISWSIDGVPIQVETDPVKKVNVFRAGFTGNLTNSLTPSPSFPRLKDASSQMSARLNKLHHGKLVECRATNLGYDEQALRPAFTKLEVHYAPVVSIQVRPPRRDNEYMEHDIITVECAAHGRPDSFMWEWFVNGRQVENIADPWYRLRLTRDMHNAVFRCIAISNKKGHTETTVRVKFGPQFLEPSPLLFTASVGEDIAMECPARGNPTPRIDWRREGGHEVLHRGVTYRKDSLRDDDFGTYICTAYVSEFPPVSKQMYISKRRPPTIQPNPVVHAKLGRTARLRCTVNSVPQPPPDQTHWYFNGRPVRQDN-HHTFEREEFLGGVVLILQIAHVMRTDYGKYNCTVRNGYGSDWKLIELSQQEDIPLQFIVGSAIAVGILIVVGLIILCACRQRICGGKYTKGRQNQ--NSSTSMRPVQAPFSEYGVINSEFKAPLSSQNGSYRSSYSPWYPNAT-VQPQTSYIGCGSDTDEQRSLTKG 652

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BLAST of NEPH-2 vs. TrEMBL
Match: A0A4S2MJ83 (Uncharacterized protein OS=Opisthorchis felineus OX=147828 GN=CRM22_000877 PE=4 SV=1)

HSP 1 Score: 439.499 bits (1129), Expect = 3.432e-135
Identity = 231/647 (35.70%), Postives = 375/647 (57.96%), Query Frame = 3

Query:  432 GNENYINVHPENQRVTLNSTVTIQCRVQPIKN------MKVYWVKSGFGLGETRSDIRSFGMVGNK--VRYDIPNDLSAGNYDLQITDVNLEDEGDFYCQMNIKNNAITSQRAQLHVLVASGPPKIIQIGNQGMGPEKLRNENSPIVVDNGDLMALRCQAERGRPGARLTWMIDNEIIEPDLS-----GNFNGIISGTITNISKKIVNNTKLRDSFSTLKAKVNQLLNGKSIKCSATNRGFEKFNFPEAKAKIEIHVAPTVTMDIVSQNLGNEFSENDWITISCSALGRPDKFLWKWYINDNEVMNDNRSSYKIKATRTMNKAVVKCIANNGKEGHDLRMLNVKYGPQFKDDSPPLYPANIGDDVTLTCNTDSNPMANIYWQRESNNDIIGHGTILYRKNIQELDFGTYICTAGVENFDLKSKKIILAKRIKPMIRENPDHRASLGRSVQAKCVIDSIPIANHNQIMWLYRGRRLINDNTKYSISTEKYVDHSISILSINNIQASDFGQYNCSVTTDLGSASKVMVLSKTSPIPLILIVGGXXXXXXXXXXXXXALCVCKRGICSNKYQKGSPTNRINSNNSTDPLKSP---------QFEMDYQCQPNFFQ-----WIPNNNREQVKSSFVRYGQDVDDRSSIRNG 2291
            G +  I +HP++Q VTLNSTV +QCRV+ + +       +VYW K+ FG+G +R DI+ +G        RYD+P +L  G YDLQIT+V L DEG + CQ+N   +   SQ A L V V S  PK+ Q+ N+G GPE      +P +VD+G ++ L+C A  G+PGA ++W ID   I+ +         F    +G +TN      +  +L+D+ S + A++N+L +GK ++C ATN G+++     A  K+E+H AP V++ +      NE+ E+D IT+ C+A GRPD F+W+W++N  +V N     Y+++ TR M+ AV +CIA + K+GH    + VK+GPQF + SP L+ A++G+D+ + C    NP   I W+RE  ++++  G    + ++++ DFGTYICTA V  F   SK++ ++KR  P I+ NP   A LGR+ + +C ++S+P    +Q  W + GR +  DN  ++   E+++   + IL I ++  +D+G+YNC+V    GS  K++ LS+   IPL  IVG  + + +++++ +I LC C++ IC  KY KG      NS+ S  P+++P         +F+     Q   ++     W PN    Q ++S++  G D D++ S+  G
Sbjct:   39 GVDGIIQIHPDSQAVTLNSTVRLQCRVRILTDPQTGAGAQVYWSKNDFGIGGSREDIQEYGRSSRYPYSRYDLPYNLKDGQYDLQITNVELSDEGSYVCQVNFMKHQYLSQTALLTVQVPSEAPKLYQVTNEGKGPEVEIGSATPAIVDDGAILVLKCVARHGKPGAIISWSIDGVPIQVETDPVKKVNVFRAGFTGNLTNSLTPSPSFPRLKDASSQMSARLNKLHHGKLVECRATNLGYDEQALRPAFTKLEVHYAPVVSIQVRPPRRDNEYMEHDIITVECAAHGRPDSFMWEWFVNGRQVENIADPWYRLRLTRDMHNAVFRCIAISNKKGHTETTVRVKFGPQFLEPSPLLFTASVGEDIAMECPARGNPTPRIDWRREGGHEVLHRGVTYRKDSLRDDDFGTYICTAYVSEFPPVSKQMYISKRRPPTIQPNPVVHAKLGRTARLRCTVNSVPQPPPDQTHWYFNGRPVRQDN-HHTFEREEFLGGVVLILQIAHVMRTDYGKYNCTVRNGYGSDWKLIELSQQEDIPLQFIVGSAIAVGILIVVGLIILCACRQRICGGKYTKGRQNQ--NSSTSMRPVQAPFSEYGVINSEFKAPLSSQNGSYRSSYSPWYPNAT-VQPQTSYIGCGSDTDEQRSLTKG 681

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BLAST of NEPH-2 vs. TrEMBL
Match: A0A0H3YJJ7 (NEPH-3 (Fragment) OS=Schmidtea mediterranea OX=79327 GN=NEPH-3 PE=2 SV=1)

HSP 1 Score: 436.032 bits (1120), Expect = 8.199e-135
Identity = 274/811 (33.79%), Postives = 435/811 (53.64%), Query Frame = 3

Query:  438 ENYINVHPENQRVTLNSTVTIQCRVQPIKNMKVYWVKSGFGLGETRSDIRSFGMVG-NKVRYDIPNDLSAGNYDLQITDVNLEDEGDFYCQMNIKNNAITSQRAQLHVLVASGPPKIIQIGNQGMGPEKLRNENSPIVVDNGDLMALRCQAERGRPGARLTWMIDNEIIEPDLSGNFN-GIISGTITNISKKIVNNTKLRDSFSTLKAKVNQLLNGKSIKCSATNRGFEKFNFPEAKAKIEIHVAPTVTMDIVSQNLGNEFSENDWITISCSALGRPDKFLWKWYINDNEVMNDNRSSYKIKATRTMNKAVVKCIANNGKEGHDLRMLNVKYGPQFKD-DSPPLYPANIGDDVTLTCNTDSNPMANIYWQRESNNDIIGHGTILYRKNIQELDFGTYICTAGVENFDLKSKKIILAKRIKPMIRENPDHRASLGRSVQAKCVIDSIPIANHNQIMWLYRGRRLINDNTKYSISTEKYVDHSISILSINNIQASDFGQYNCSVTTDLGSASKVMVLSKTSPIPLILIVGGXXXXXXXXXXXXXALCVCKRGICSNKYQKGSPTN-RINSNNSTDPLKSPQFEMDYQCQPNFFQWIPNNNREQVKSSFVRYGQDVDDRSSIRNGSINQYRGLDMCSTYTSSIPGSQNGEKPIRNPDIDDVYKEEFYPSSNPAMMCSMHITPTGSGAINRAS----------PCNAHPYSVPQHQISLPQYNFTSFANPPYLSNYLPGSNNNFALPSYPVHSPSSEPGINGGSGLMIPPVLPPIDTNDANHNVELGLSPQQTSFIKPGMTISQNMANYLSPNIR 2828
            ++YI VHPE Q   LNST+T++CRV+ ++  +V+WVK GFGLG +R+DIR +G    ++ R+D+P +L+ G YDL+ITD+ L DEG FYCQ+ +   A +SQ+  + VLV S  P+++QI    +GP+ +RNE +PI+V++G+ + ++C A+ GRPGA L W ++   IE   +G  N   ++G IT  S+   N  KL D  ++L+ K+  L NG  +KC A N G+         A+I ++  P V +++  +   N F END +  +CSA GRP  F W W I D  ++N     YK+K TR  +   + C A +   G +   + VKYGP FKD DS  +Y A+IG+++ + C  D NP   I WQR S+N++I  G+IL R +IQ  DFG YIC A V+ F  + K I L ++  P I+         G+S +  C I SIP  N N+I W+++ ++L+ + T++ +  +      IS+L I ++Q  DFG YNCSV+T  GS    ++L + S  P+++IVG T+    +++++I+ LC+C+R    ++Y KG+P++  I  ++     KS   + D QC PN + WIP       +S  V+   DV  +   ++G+       ++ S Y++S+P SQ+  K ++      + K E   ++NP ++ +MH    G+  +NR S          P    P      Q +  QY + +  NP    N       + A P Y V  P+++                        H ++      QT F  PG  I +N  N  S N+ 
Sbjct:   37 DDYILVHPERQVAALNSTITLKCRVKVVEKYEVHWVKDGFGLGNSRTDIRQYGQRKPHQFRFDLPFNLAEGEYDLRITDLELFDEGVFYCQIVVNGKAYSSQKVLVQVLVPSDKPQLVQINK--IGPQAIRNEKNPIIVNDGEYLHIKCIAKNGRPGASLYWYLNEIKIEAQKNGVLNETFLNGKITITSESSENLPKLYDVVNSLELKIVSLKNGNWLKCLAINNGYTNQKLNYTSAQIVVYTVPIVVINVYPKKQNNIFIENDIVEFTCSASGRPSDFHWAWTIGDESLVNIRDPKYKLKITRVDHGKKITCCATSKSIGCNSTNILVKYGPNFKDSDSLTIYAASIGENMQMECRADGNPEPLITWQRISSNEVIARGSILLRNDIQADDFGDYICKAAVKEFPERHKYIYLGEKGPPEIKNPSVSYGREGQSARLSCTIKSIPFPNDNEIKWIFKNKQLL-EGTRHKMYRQINEKIVISVLHILSVQPHDFGDYNCSVSTKYGSDMATIILLRKSETPMLMIVGATIIFLFILLVIIVVLCICQRRKFKDEYMKGNPSSPEIPLHHEA---KSTLIDSDCQCNPNLYSWIP-------QSFDVKSQNDVLSKIHYQDGNFWP-NSQEIESCYSNSVPDSQSSNKSVK------ITKHE-NANTNP-ILYNMHT--IGTNTLNRYSTNMPFTNLPIPREKDPRFCDSSQCT--QYLYQNLYNPVVEHNSQLNPTESTASPIYIVKKPANK-----------------------KHQIQF-----QTDFYSPGKPIIKNKLNSGSANME 793

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BLAST of NEPH-2 vs. Ensembl Cavefish
Match: KIRREL3 (kirre like nephrin family adhesion molecule 3 [Source:HGNC Symbol;Acc:HGNC:23204])

HSP 1 Score: 165.236 bits (417), Expect = 9.531e-42
Identity = 133/523 (25.43%), Postives = 228/523 (43.59%), Query Frame = 3

Query:  456 HPENQRVTLNSTVTIQCRVQPIKNMKVYWVKSGFGLGETRSDIRSFGMVGNKVRYDIPNDLSAGNYDLQITDVNLEDEGDFYCQMNIKNNAITSQRAQLHVLVASGPPKIIQIGNQGMGPEKLRNENSPIV-VDNGDLMALRCQAERGRPGARLTWMIDNEIIEPDLSGNFNGIISGTITNISKKIVNNTKLRDSFSTLKAKVNQLLNGKSIKCSATNRGFEKFNFPEAKAKIEIHVAPTVTMDIVSQNLGNEFSENDWITISCSALGRPDKFLWKWYINDNEVMNDNRSSYKIKATRTMNKAVVKCIANNGKEGHDL-RMLNVKYGPQFKDDSPPLYPANIGDDVTLTCNTDSNPMANIYWQRESNNDIIGHGTILYRKNIQELDFGTYICTAGVENFDLKSKKIILAKRIKPMIRENPDHRASLGRSVQAKCVIDSIPIANHNQIMWLYRGRRLINDNT-KYSISTEKYVDHSISILSINNIQASDFGQ-YNCSVTTDLGSASKVMVLSKTSPIPLILIVG 2012
             P++  V     VT+ C + P  +  V W+K G  LG  R D+  +       RY +  D S+G + L+I  V L D+  F CQ      A+ S+ A+L VLV    P I               +  PIV +  GD + L C A+  +P A + W+ + E++        NG +       SK ++ + +   + STL    + +  G+ I C A+N+     N  E    I+I   P V + +  Q +     E + +   CSA   P    +KW      +   +  +Y++    +     V C   N     ++ R ++V +GP+   + P     ++G D    C    NP   I W +  +  ++ +  IL  K +++ D G Y+C A V       K++ L     P I     H+A  G   Q KC I S P    ++I W ++   L +  + +Y++ T    D  +S L+++NI  +DF   YNC+     GS ++++ L +   +P+ +I+G
Sbjct:    5 QPQDLVVVAGQPVTLPCSI-PGYHGVVLWIKDGLALGVGR-DLSGYP------RYTVVGDHSSGEHHLRIQRVELMDDAVFECQA--IQAAMRSRPARLTVLVPPEDPVI---------------DGGPIVSLRAGDPLNLTCHADNAKPAASIIWIRNGEVL--------NGAM------YSKTLLRDGRRESTVSTLYISPSNIETGQKIICRASNKAIP--NGKETSVTIDIQHLPLVNLSVEPQPV----LEGNLVKFHCSAKANPPVTQYKWAKGGTVIKEVSGDTYEVIVDHSFFTEAVSCEVTNPLGSTNISRNVDVYFGPRMAAE-PQSLQVDLGSDAVFNCAWTGNPSLTIVWMKRGSGVVLSNENILTLKAVRQEDAGKYVCRAVVPRVGAGEKEVSLTVNGPPTISSTQTHQAPHGEKGQIKCFIRSTPPP--DRIAWSWKETVLESGTSGRYTVETVSTEDGVLSTLTMSNIVPADFQTIYNCTAWNSFGSDTEIIRLKEQESLPVAVIIG 479

[Close]

BLAST of NEPH-2 vs. Ensembl Cavefish
Match: KIRREL3 (kirre like nephrin family adhesion molecule 3 [Source:HGNC Symbol;Acc:HGNC:23204])

HSP 1 Score: 165.236 bits (417), Expect = 1.245e-41
Identity = 133/523 (25.43%), Postives = 228/523 (43.59%), Query Frame = 3

Query:  456 HPENQRVTLNSTVTIQCRVQPIKNMKVYWVKSGFGLGETRSDIRSFGMVGNKVRYDIPNDLSAGNYDLQITDVNLEDEGDFYCQMNIKNNAITSQRAQLHVLVASGPPKIIQIGNQGMGPEKLRNENSPIV-VDNGDLMALRCQAERGRPGARLTWMIDNEIIEPDLSGNFNGIISGTITNISKKIVNNTKLRDSFSTLKAKVNQLLNGKSIKCSATNRGFEKFNFPEAKAKIEIHVAPTVTMDIVSQNLGNEFSENDWITISCSALGRPDKFLWKWYINDNEVMNDNRSSYKIKATRTMNKAVVKCIANNGKEGHDL-RMLNVKYGPQFKDDSPPLYPANIGDDVTLTCNTDSNPMANIYWQRESNNDIIGHGTILYRKNIQELDFGTYICTAGVENFDLKSKKIILAKRIKPMIRENPDHRASLGRSVQAKCVIDSIPIANHNQIMWLYRGRRLINDNT-KYSISTEKYVDHSISILSINNIQASDFGQ-YNCSVTTDLGSASKVMVLSKTSPIPLILIVG 2012
             P++  V     VT+ C + P  +  V W+K G  LG  R D+  +       RY +  D S+G + L+I  V L D+  F CQ      A+ S+ A+L VLV    P I               +  PIV +  GD + L C A+  +P A + W+ + E++        NG +       SK ++ + +   + STL    + +  G+ I C A+N+     N  E    I+I   P V + +  Q +     E + +   CSA   P    +KW      +   +  +Y++    +     V C   N     ++ R ++V +GP+   + P     ++G D    C    NP   I W +  +  ++ +  IL  K +++ D G Y+C A V       K++ L     P I     H+A  G   Q KC I S P    ++I W ++   L +  + +Y++ T    D  +S L+++NI  +DF   YNC+     GS ++++ L +   +P+ +I+G
Sbjct:    5 QPQDLVVVAGQPVTLPCSI-PGYHGVVLWIKDGLALGVGR-DLSGYP------RYTVVGDHSSGEHHLRIQRVELMDDAVFECQA--IQAAMRSRPARLTVLVPPEDPVI---------------DGGPIVSLRAGDPLNLTCHADNAKPAASIIWIRNGEVL--------NGAM------YSKTLLRDGRRESTVSTLYISPSNIETGQKIICRASNKAIP--NGKETSVTIDIQHLPLVNLSVEPQPV----LEGNLVKFHCSAKANPPVTQYKWAKGGTVIKEVSGDTYEVIVDHSFFTEAVSCEVTNPLGSTNISRNVDVYFGPRMAAE-PQSLQVDLGSDAVFNCAWTGNPSLTIVWMKRGSGVVLSNENILTLKAVRQEDAGKYVCRAVVPRVGAGEKEVSLTVNGPPTISSTQTHQAPHGEKGQIKCFIRSTPPP--DRIAWSWKETVLESGTSGRYTVETVSTEDGVLSTLTMSNIVPADFQTIYNCTAWNSFGSDTEIIRLKEQESLPVAVIIG 479

[Close]

BLAST of NEPH-2 vs. Ensembl Cavefish
Match: kirrel3a (kirre like nephrin family adhesion molecule 3a [Source:ZFIN;Acc:ZDB-GENE-091117-44])

HSP 1 Score: 157.532 bits (397), Expect = 3.234e-39
Identity = 134/523 (25.62%), Postives = 222/523 (42.45%), Query Frame = 3

Query:  456 HPENQRVTLNSTVTIQCRVQPIKNMKVYWVKSGFGLGETRSDIRSFGMVGNKVRYDIPNDLSAGNYDLQITDVNLEDEGDFYCQMNIKNNAITSQRAQLHVLVASGPPKIIQIGNQGMGPEKLRNENSPIV-VDNGDLMALRCQAERGRPGARLTWMIDNEIIEPDLSGNFNGIISGTITNISKKIVNNTKLRDSFSTLKAKVNQLLNGKSIKCSATNRGFEKFNFPEAKAKIEIHVAPTVTMDIVSQNLGNEFSENDWITISCSALGRPDKFLWKWYINDNEVMNDNRSSYKIKATRTMNKAVVKCIANNGKEGHDL-RMLNVKYGPQFKDDSPPLYPANIGDDVTLTCNTDSNPMANIYWQRESNNDIIGHGTILYRKNIQELDFGTYICTAGVENFDLKSKKIILAKRIKPMIRENPDHRASLGRSVQAKCVIDSIPIANHNQIMWLYRGRRLINDNT-KYSISTEKYVDHSISILSINNIQASDFGQ-YNCSVTTDLGSASKVMVLSKTSPIPLILIVG 2012
             P +  V     VT+ C +     M V W   G  LG  R D+  +       RYD+  D S G Y L I    L D+G F CQ       I S+ A+L VLV    P II                +PIV +  GD + L C A+  +P A + W+ + E++        NG +       SK ++ + +   + STL    + + +G+ I C A+N+     N  EA   I+I   P V + +  Q +     E + +   CSA   P    ++W      + +    SY+     +     V C   N     ++ R ++V +GP+   + P     ++G D    C    NP   I W +  +  ++ +   L  K +++ D G Y+C A V    +  K++ L     P I      +A  G   Q KC I S P    ++I W ++   L +  + +Y++ T    +  IS L+++NI  +DF   YNC+     GS ++++ L +   + L +I+G
Sbjct:   34 QPHDVVVVAGQPVTLPCSITGFHGM-VLW--DGLALGVNR-DLSGYP------RYDVIGDHSKGEYHLLIQRTELGDDGSFECQG--IQAGIRSRPARLTVLVPPDDPVII---------------GAPIVSLRAGDPLNLTCHADNAKPAASIIWIRNGEVL--------NGAM------YSKTLLRDGQRESTVSTLYISASNIESGQRITCRASNKAAP--NGKEATVTIDIQHLPLVNLSVEPQPI----LEGNLVKFHCSAKANPPVTHYRWAKGGAVIRDVLGDSYEAVVDHSFFTEPVSCEVTNALGSTNISRNVDVYFGPRLAAE-PQSLQVDLGSDAVFNCAWTGNPSLTIVWMKRGHGVVLSNENTLTLKAVKQEDAGKYVCRAVVPRVGVGEKEVTLTVNGPPTISSTQTQQALYGEKGQIKCFIRSTPPP--DRIAWSWKETVLESGTSGRYTVETVSTEEGVISTLTMSNIVPADFQTIYNCTAWNSFGSDTEIIRLKEQGSLRLAVIIG 506

[Close]

BLAST of NEPH-2 vs. Ensembl Cavefish
Match: kirrel1a (kirre like nephrin family adhesion molecule 1 [Source:NCBI gene;Acc:103031116])

HSP 1 Score: 149.058 bits (375), Expect = 2.360e-36
Identity = 131/532 (24.62%), Postives = 220/532 (41.35%), Query Frame = 3

Query:  456 HPENQRVTLNSTVTIQCRVQPIKNMKVYWVKSGFGLGETRSDIRSFGMVGNKVRYDIPNDLSAGNYDLQITDVNLEDEGDFYCQMNIKNNAITSQRAQLHVLVASGPPKIIQIGNQGMGPEKLRNENSP-IVVDNGDLMALRCQAERGRPGARLTWMIDNEIIEPDLSGNFNGIISGTITNISKKIVNNTKLRDSFSTLKAKVNQLLNGKSIKCSATNRGFEKFNFPEAKAKIEIHVAPTVTMDIVSQNLGNEFSENDWITISCSALGRPDKFLWKWYINDNEVMNDNRSSYKIKATRTMNKAVVKCIANNGKEGHDLRML-NVKYGPQFKDDSPPLYPANIGDDVTLTCNTDSNPMANIYWQRESNNDIIGHGTILYRKNIQELDFGTYICTAGVENFDLKSKKIILAKRIKPMIRENPDHRASLGRSVQAKCVIDSIPIANHNQIMWLYRGRRLINDNTKYSISTEKYVDHS---------ISILSINNIQASDF-GQYNCSVTTDLGSASKVMVLSKTSPIPLILIVGG 2015
             P +Q V L   V + C V     + V W K G  LG    D+R++       RY +   +  G Y+L+I+   L D+  + CQ      A+ S+RA+L VL+    P I               E SP I++  G    L C +   +P A + W  D   IE    G F+          + +++ + K   + S L         GK+  C ATN              + +H  P V + I  +++     E + +T +C A   P    +KW      +     S +  KA  +     V C   N     ++ +L +V +GP    +  P+   +   DVTL C    NP   + W ++ ++ ++ +   LY K++ + D G Y+C A V    +   ++ L     P+I   P   A  G   + KC I S P    ++I+W ++    + +  K ++     V+ S         +S L+INN+  SDF   YNC+     G  + ++ L +T  +P+ +I GG
Sbjct:    7 EPADQSVVLGQRVVLSCVVFNYSGI-VQWTKDGLALG-IGEDLRAW------PRYRVLRMVDIGQYNLEISSAELSDDSLYECQAT--EAALRSRRAKLTVLIPPDEPVI---------------EGSPEILLTAGVPHNLSCVSRGAKPPAAIEWQKDGLPIE----GAFS----------TTEVLPDRKRVTTRSFLPVLPVDTDTGKNFTCMATNPAVPMGK--RTTITLNVHHPPVVVLSIEPRSV----LEGERVTFTCQATANPPIMGYKWAKGGVVIQGARESVFITKADHSFFTEPVSCQVFNAVGSTNVSILVDVHFGPILVVEPKPVT-VDSDSDVTLNCKWAGNPPLTLTWTKKGSSMVLSNNNQLYLKSVSQADAGQYVCKAIVPRIGVGETEVTLTVNGPPIISSEPVQYAVRGERGEVKCYIASTPPP--DKIVWAWKEN--VWEKEKGTLPERYTVEQSKPSSDGGAVLSTLTINNVMESDFQSTYNCTAWNGFGPGTMIITLEETEVVPVGIIAGG 488

[Close]

BLAST of NEPH-2 vs. Ensembl Cavefish
Match: kirrel1b (kirre like nephrin family adhesion molecule 1b [Source:ZFIN;Acc:ZDB-GENE-070912-173])

HSP 1 Score: 133.65 bits (335), Expect = 1.441e-31
Identity = 125/524 (23.85%), Postives = 217/524 (41.41%), Query Frame = 3

Query:  456 HPENQRVTLNSTVTIQCRVQPIKNMKVYWVKSGFGLGETRSDIRSFGMVGNKVRYDIPNDLSAGNYDLQITDVNLEDEGDFYCQMNIKNNAITSQRAQLHVLVASGPPKIIQIGNQGMGPEKLRNENSP-IVVDNGDLMALRCQAERGRPGARLTWMIDNEIIEPDLSGNFNGIISGTITNISKKIVNNTKLRDSFSTLKAKVNQLLNGKSIKCSATNRGFEKFNFPEAKAKIEIHVAPTVTMDIVSQNLGNEFSENDWITISCSALGRPDKFLWKWYINDNEVMNDNRSSYKIKATRTMNKAVVKCIANNGKEGHDLRML-NVKYGPQFKDDSPPLYPANIGDDVTLTCNTDSNPMANIYWQRESNNDIIGHGTILYRKNIQELDFGTYICTAGVENFDLKSKKIILAKRIKPMIRENPDHRASLGRSVQAKCVIDSIPIANHNQIMWLY--------RGRRLINDNTKYSISTEKYVDHS---ISILSINNIQASDF-GQYNCSVTTDLGSASKVMVLSKTS 1985
             P +Q V L   V + C V     + V W K G  LG    D+R++       RY +   +  G Y+L+I+   L D+  + CQ      A+ S+RA+L VL+    P I               E +P I++  G    L C +   +P + + W  D  I++                + S +++ + K   + S L  +      G +  C A+N          A   + +H APTV + I  +++     E + +T +C A   P    ++W      +     S +   A  +     V C   N     ++ +L +V +GP    +  P+   ++  DVTL C    NP   + W ++ ++ ++ +   LY K++ + D G Y+C A V    +   ++ L     P+I   P   A  G   + KC I S P    ++I+W +        RG  L     +Y++   K V      +S L+INN+  SDF   YNC+     G  + ++ L++T+
Sbjct:   28 EPADQSVVLGERVVLSCVVFNYTGI-VQWTKDGLALG-IGEDLRAWP------RYRVLRIVDVGQYNLEISSSELSDDSLYECQAT--EAALRSRRAKLTVLIPPDDPVI---------------EGAPEILLMAGVPYNLTCVSRGAKPLSTIEWYKDGVIVDG--------------AHTSTEVLADRKRVTTRSFLPIQPVDTDTGHNFSCVASNLAVPLGK--RATITLNVHHAPTVLLSISPRSV----LEGERVTFTCQATANPPVMGYRWAKGGVILEGARESVFVTTADHSFFTEPVSCQVFNAVGSTNVSILVDVHFGPILVVEPRPVT-VDVDSDVTLNCKWAGNPPLTLTWTKKGSSMVLSNNNQLYLKSVSQADAGQYVCKAIVPRIGVGETEVTLTVNGPPIISSEPVQYAVRGEKGEIKCYIASTPPP--DKIVWAWKENVWEKERGTLL----ERYTVEQSKPVSQGGAVLSTLTINNVMESDFQSTYNCTAWNSFGPGTMIITLAETA 499

[Close]

BLAST of NEPH-2 vs. Ensembl Sea Lamprey
Match: ENSPMAT00000010550.1 (pep scaffold:Pmarinus_7.0:GL479154:26986:35474:-1 gene:ENSPMAG00000009556.1 transcript:ENSPMAT00000010550.1 gene_biotype:protein_coding transcript_biotype:protein_coding)

HSP 1 Score: 85.1149 bits (209), Expect = 4.856e-18
Identity = 51/184 (27.72%), Postives = 87/184 (47.28%), Query Frame = 3

Query: 1428 GPQFKDDSPPLYPANIGDDVTLTCNTDSNPMANIYWQRESNNDIIGHGTILYRKNIQELDFGTYICTAGVENFDLKSKKIILAKRIKPMIRENPDHRASLGRSVQAKCVIDSIPIANHNQIMWLYRGRRL-INDNTKYSISTEKYVDHSISILSINNIQASDF-GQYNCSVTTDLGSASKVMVL 1973
            GP+   +  P    + G D T TC    NP   + W R+ +N ++ +  +L  K + + D G Y+C A V    +  K+++L     P+I  +    A  G   + +C I S P A+H  + W ++   L +    +Y++ T   VD  +S L+I N+   DF   YNC+     GS +++  L
Sbjct:    1 GPRIVTEPQP-QTVDRGSDATFTCAWSGNPPLTLAWTRKGSNVVLSNSNMLLLKGVTQDDTGRYVCKAIVPRIGVGEKEVMLNVNGPPIISSDLLQHALRGEKGRVECFIGSTPPAHH--LAWAWKENVLEVGTYERYTVETVSRVDGVLSTLTITNVMEGDFQTAYNCTAWNGFGSDTEIFTL 181

[Close]

BLAST of NEPH-2 vs. Ensembl Sea Lamprey
Match: ENSPMAT00000010567.1 (pep scaffold:Pmarinus_7.0:GL479154:561817:685780:1 gene:ENSPMAG00000009565.1 transcript:ENSPMAT00000010567.1 gene_biotype:protein_coding transcript_biotype:protein_coding)

HSP 1 Score: 70.8626 bits (172), Expect = 1.449e-12
Identity = 119/539 (22.08%), Postives = 193/539 (35.81%), Query Frame = 3

Query:  447 INVHPENQRVTLNSTVTIQCRVQPIKNMKVYWVKSGFGLGETRSDIRSFGMVGNKVRYDIPNDLSAGN-YDLQITD--VNLEDEGDFYCQMNIKNNAITSQRAQLHVLVASGPPKIIQIGNQGMGPEKLRNENSPIVVDNGDLMALRCQAERGRPGARLTWMIDNEIIEPDLSGNFNGIISGTITNISKKI-VNNTKLRDSFSTLKAKVNQLLNGKSIKCSATNRGFEKFNFPEAKAKIEIHVAPTVTMDIVSQNLGNEFSENDWITISCSALGRPDKFLWKWYINDNEVMNDNR----SSYKIKATRT--MNKAVVKCIANN--GKEGHDLRMLNVKYGPQFKDDSPPLYPANIGDDVTLTCNTDSNPMANIYWQRESNNDII-----------------GHGTILYRKNIQELDFGTYICTAGVENFDLKSKKII-----LAKRIKPMIRENPDHRA-SLGRSVQAKCVIDSIPIANHNQIMWLYRGRRLINDNTKYSISTEKYVDHSISILSINNIQASDFGQYNCSVTTDLGSAS 1958
            I  HP +  V+     T+ C+ +      V W K G  +   R D RS  M+           L  G+ + L+I        DEG + C          S+ A L V                      R+  S + V   +   + C+  RG P             EP +S   NG+    +T+  +++ +   KL  S +T KA     +      C  TN   E+ + P   A  E        M++V   L +  +E       C   G P   + +W   D ++   +R      Y ++  R    ++    C+  N  GK      ++ V   PQF    P       G   T  C T  NP   ++WQRE + +++                 GH TI    ++Q  D G Y C A      + +K ++     LA    P+IR+ P ++  ++G      C    +P  +   + WL        D +K S+ + +    S   LSI ++Q  D G Y C   +  G  +
Sbjct:   32 IAEHPSDLIVSRGEPATLNCKAEGRPAPTVEWYKDGERVETDRDDPRSHRML-----------LPTGSLFFLRIVHGRRTKTDEGSYVCVARNYLGEAVSRNASLEVANIR---------------RNYRSSPSAVKVAAREPAVMECRPPRGHP-------------EPTVSWKRNGV---ALTDKDERVTIRGGKLMIS-NTQKADAGMYV------CVGTNMVGERDSEPAELAVFERPTFARKPMNLVM--LADSDAE-----FRCEVHGDPPPTV-RWRKEDGDLPKGSRFEIQDDYTLRVERVGGTDEGTYTCVGENRVGKAEASASLV-VHAPPQFVV-RPRDQIVAQGQSATFLCETTGNPPPAVFWQREGSQNLLFPNQPSQPSSRFSVSQTGHLTI---TDVQRSDSGYYTCQALSVAGSILAKALLEVGDALADSPPPIIRQGPANQTLAVGSVALLACQAMGMPTPS---VHWL-------KDGSKLSLGSARLGLQSGGTLSIKDVQLMDAGLYTCVAVSPSGETT 498

[Close]

BLAST of NEPH-2 vs. Ensembl Sea Lamprey
Match: pxdn (peroxidasin [Source:ZFIN;Acc:ZDB-GENE-140415-2])

HSP 1 Score: 63.5438 bits (153), Expect = 2.151e-10
Identity = 93/407 (22.85%), Postives = 157/407 (38.57%), Query Frame = 3

Query:  819 KLRNENSPIVVDNGDLMALRCQAERGRPGARLTWMIDNEIIEPDLSGNFNGIISGTITNISKKIVNNTKLRDSFSTLKAKVNQLLNGKSIKCSATNRGFEKFNFPEAKAK-IEIHVAPTVTMDIVSQNLGNEFSENDWITISCSALGRPDKFLWKWYINDNEVM-NDNRSSYKIKATRTMNKA------VVKCIANNGKEG-HDLRMLNVKYGPQFKDDSPPLYPANIGDDVTLTCNTDSNPMANIYWQRESNN-------DIIGHGTILYRKNIQELDFGTYICTA-GVENFDLKSKKIILAKRIKPMIRENP-DHRASLGRSVQAKCVIDSIPIANHNQIMWLYRGRRLINDNTKYSISTEKYVDHSISILSINNIQASDFGQYNCSVTTDLGSASKVMVLSKTS 1985
            ++ +E   + V  G+ + LRC+AE G P   + W+ ++  I        N +  GT+      ++ +T+  D                + +C A N   E    PE   +  ++   PT     V Q    E    + +T+ CSA G P   +  W  +D+E +  D R S        + +A         C A+N ++       + +K  PQF   +P       G  V L C     P+  I W +  +         ++  GT+   + +   D G + C A  V      + ++ +  R+ P+    P D     GR V+  C     P      +MW   G   I ++ K+ +S E Y       L I +   +D G+Y C     +G AS  M+LS T+
Sbjct:  184 RITSEPHDVDVTPGNTVYLRCRAE-GNPKPAIIWLHNSNEIAMAEDERRNLLQDGTL------MIRDTRHTDQ--------------GTYQCMARNVAGE-VKAPEVVLRYFDVPAPPT----FVIQPHDTEVLVGESVTLECSAGGHPAPRV-SWTRDDSEQLPADPRFSVTASGGLHVERAGPGDEGRYTCHASNNQDSIRASATILLKSAPQFI-LAPEDQVVTEGHTVDLHCEAQGRPLPVIAWTKAGSQLPSDRRLTVLSSGTLRIAR-VALHDQGQFECQAVNVVGVRRAATQLTVLPRVTPVFSVTPSDITTDSGRDVRIACSAQGEP---QPSLMWAKDGVH-ITESGKFHVSAEGY-------LEIRDAGPADQGRYECIARNSIGHASTSMLLSVTA 550

HSP 2 Score: 62.003 bits (149), Expect = 7.538e-10
Identity = 61/279 (21.86%), Postives = 108/279 (38.71%), Query Frame = 3

Query: 1230 ITISCSALGRPDKFLWKWYINDNEVM--NDNR------SSYKIKATRTMNKAVVKCIANNGKEGHDLRMLNVKYGPQFKDDSPPLY---PAN----IGDDVTLTCNTDSNPMANIYWQRESNNDI-------IGHGTILYRKNIQELDFGTYICTAGVENFDLKSKKIILAKRIKPMIRENPDHRASLGRSVQAKCVIDSIPIANHNQIMWLYRGRRLINDNTKYSISTEKYVDHSISILSINNIQASDFGQYNCSVTTDLG---SASKVMVLSKTSPI 1991
            + + C A G P   +  W  N NE+    D R       +  I+ TR  ++   +C+A N         + ++Y   F   +PP +   P +    +G+ VTL C+   +P   + W R+ +  +       +     L+ +     D G Y C A      +++   IL K     I    D   + G +V   C     P+     I W   G +L +D     +S+          L I  +   D GQ+ C     +G   +A+++ VL + +P+
Sbjct:  200 VYLRCRAEGNPKPAII-WLHNSNEIAMAEDERRNLLQDGTLMIRDTRHTDQGTYQCMARNVAGEVKAPEVVLRY---FDVPAPPTFVIQPHDTEVLVGESVTLECSAGGHPAPRVSWTRDDSEQLPADPRFSVTASGGLHVERAGPGDEGRYTCHASNNQDSIRASATILLKSAPQFILAPEDQVVTEGHTVDLHCEAQGRPLP---VIAWTKAGSQLPSDRRLTVLSS--------GTLRIARVALHDQGQFECQAVNVVGVRRAATQLTVLPRVTPV 463

[Close]

BLAST of NEPH-2 vs. Ensembl Sea Lamprey
Match: cntn3b (contactin 3b [Source:ZFIN;Acc:ZDB-GENE-130530-645])

HSP 1 Score: 61.6178 bits (148), Expect = 7.686e-10
Identity = 69/286 (24.13%), Postives = 113/286 (39.51%), Query Frame = 3

Query: 1209 EFSENDWITISCSALGRPDKFLWKWYINDNEVMN-------DNRSSYKIKATRTMNKAVVKCIANNGK----EGHDLRMLNVKYGPQFKDDSPPLYPANI--GDDVTLTCNTDSNPMANIYWQRESNNDIIGHGTILYRKN---------IQELDFGTYICTAGVENFDLKSKKIILAKRIKP--MIRENPDHRASLGRSVQAKCVIDSIPIANHNQIMWLYRGRRL--INDNTKYSISTEKYVDHSISILSINNIQASDFGQYNCSVTTDLGSASKVMVLSKTSP 1988
            E    D ++ +C A G P  F ++W + D E +         +  +  I A    +  + +C A NG        +LR+L  +Y P F   SP    A++  G   TL C   ++P A I W+R     I+    +  R+           ++ D G Y C A  EN   ++   +     +P  M R   D  A++  SV   C   +     +    W   GR L    D  K+ I+++         L+I  ++ +D G+Y C+  T + S S    L    P
Sbjct:  221 ELDIGDRLSWACEARGHPAPF-YRW-LRDGEALRPGGPVELGDDGTLTISAVDLSHSGMYQCEARNGNGTIYSAAELRVL--EYAPHF-GSSPDPGTAHVVRGGAATLLCRPRASPHATISWERH-GAPILNSSRVFVRERDSSLLILNATEDADGGAYTCVA--ENARGRANLTVQLHVQEPTRMSRPPTDVTANVSDSVLLPCQASAAAAGMNIAYTWEALGRTLDPGRDAEKFWIASQ---SEDSGDLTIVKVRLADSGRYTCTARTPIDSVSASATLRVKGP 495

[Close]

BLAST of NEPH-2 vs. Ensembl Sea Lamprey
Match: ENSPMAT00000004946.1 (pep scaffold:Pmarinus_7.0:GL501092:7822:21335:1 gene:ENSPMAG00000004486.1 transcript:ENSPMAT00000004946.1 gene_biotype:protein_coding transcript_biotype:protein_coding)

HSP 1 Score: 56.6102 bits (135), Expect = 1.909e-8
Identity = 74/338 (21.89%), Postives = 126/338 (37.28%), Query Frame = 3

Query:  657 LQITDVNLEDEGDFYCQMNIKNNAITSQRAQLHVLVASGPPKIIQIGNQGMGPEKLRNENSPIVVDNGDLMALRCQAERGRPGARLTWMID-NEIIEPDLSGNFNGIISGTITNISKKIVNNTKLRDSFSTLKAKVNQLLNGKSIKCSATNRGFEKFNFPEAKAKIEIHVAPTVTMDIVSQNLG-------NEFSENDWITISCSALGRPDKFLWKWYINDNEVMNDNRSSYKIKATRTMNKAVVKCIANNGKE-----GHDLRMLNVKYGPQFKDDSPPLYPANIGDDVTLTCNTDSNPMANIYWQRESNNDIIGHGTILYRKNIQELDFGTYICTA 1631
            L + +V+L D+ +F C + +      S +  ++V   S P  I+         +++  E +  V D        C A+ G P  ++ W  + N IIE  +    N  +   +T       NN  L    S L+ +  +   G  I C     G           +IE  +A  VT+ +     G       N   E D +T++C     P      +          N++++K+         V KC A              R +NV Y  + +    P    N GD++T+TC+  S+     +W ++        G IL R ++   D G+Y C A
Sbjct:   99 LVVKNVSLVDQREFICSITLAATEAKSTKVNVYVSSKSSP-GIVSKYRATYREQQISKEYN--VAD--------CVAKDGYPEPKIVWFKNSNPIIEVKIE---NAEVMPVVTK------NNQGLFTVTSVLRMRPQKTDKGSLINCCVMTGG--------GNTEIEAPLATMVTIHLSYPPEGVSLEVFPNFIKEGDTVTLTCVTDAFPPPTYAFFQGETLLAETGNKNTFKMPYINRRQGGVYKCEARYTSSPMQTTAKAERQINVHYIERLRIMGIPDGEVNKGDNITMTCSASSSGNITYHWNKDGERK--EDGRILTRLHVTSYDSGSYTCVA 406

[Close]

BLAST of NEPH-2 vs. Ensembl Nematostella
Match: EDO45383 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7RT26])

HSP 1 Score: 58.151 bits (139), Expect = 1.008e-8
Identity = 46/166 (27.71%), Postives = 75/166 (45.18%), Query Frame = 3

Query:  459 PENQRVTLNSTVTIQCRVQPIKNMKVYWVKSGFGLGET--RSDIRSFGMVGNKVRYDIPNDLSAGNYDLQITDVNLEDEGDFYCQMNIKNNAITSQRAQLHVLVASGPPKIIQIGNQGMGPEKLRNENSPIVVDNGDLMALRCQAERGRPGARLTWMIDNEIIEPD 950
            P+N+ VT  S VT+ C+++      V W+K    L  +  R  +   G  GN                L IT++   DE  + C+     NA   + ++  +L  + PPK ++I    +  E++RNE         D + L C+ E G+P A + W+ DN  +EPD
Sbjct:  319 PKNETVTEKSNVTLTCQLECKPKCSVTWLKDNTPLDTSPDRITVTHPGSYGNTTS------------SLTITNLVRTDEARYSCKAI---NAAGEKSSEQGLLTVNYPPKFLEI----LKAEEMRNET--------DNLTLTCKLE-GKPLATVLWLKDNTELEPD 456

[Close]

BLAST of NEPH-2 vs. Ensembl Nematostella
Match: EDO30451 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7T0R2])

HSP 1 Score: 56.225 bits (134), Expect = 1.418e-8
Identity = 62/261 (23.75%), Postives = 108/261 (41.38%), Query Frame = 3

Query: 1230 ITISCSALGRPDKFLWKWYINDNEVMNDNRS----SYKIKATRTMNKA---VVKCIANNGKEGHDLRMLNVK--YGPQFKDDSPPLYPANIGDDVTLTCNTDSNPMANIYWQRESNNDIIGHGTILYRKNIQELDFGTYICTAGVENFDLKSKKIILAKRIKPMIRENPDHRASLGRSVQA-KCVIDSIPIANHNQIMWLYRGRRLINDNTKYSISTEKYVDHSISILSINNIQ-ASDFGQYNCSVTTDLGSASKVMVLSK 1979
            +++ C A G P   +  WY   ++ +    S      +++ T T +       KC A+N   G   R++ V   Y P F  +SP        D + LTC +D  P   + W R+    ++   ++ Y  ++   + GTY CTA  E     +  + +    KP +  +  + +S  R V + +C    +P      I W   G + I       IS         S L +   Q A D+GQY C  +  LGS  +++ +++
Sbjct:    2 LSLQCKARGVPSPQI-TWYRPGDQPITAGVSPISGGSQLQVTTTQDAGDYGQYKCRASN-LLGSVERLIYVTQWYKPSFISNSPYQTVNETIDFLKLTCESDGYPAPTVTWSRD--GVVVSQTSVYYSNSVTRSEAGTYTCTATNE-MGSDTTTVQVTVNYKPEMASSTTNTSSWNRKVLSLQCKARGVP---SPHITWYKPGGQPITAGVS-PISGG-------SQLQVTTTQEAGDYGQYKCRASNLLGSVERLIYVTQ 246

[Close]

BLAST of NEPH-2 vs. Ensembl Nematostella
Match: EDO29616 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7T347])

HSP 1 Score: 57.7658 bits (138), Expect = 1.503e-8
Identity = 69/302 (22.85%), Postives = 120/302 (39.74%), Query Frame = 3

Query: 1107 RGFEKFNFPEAKAKIEIHVAPTVTMDIVSQNLGNEFSENDWITISCSALGRPD-KFLWKWYINDNEVMNDNRS-SYKIKATRTMNKAVVKCIANN----GKEGHDLRMLNVKYGPQFKDDSPPLYPANI--GDDVTLTCNTDSNPMANIYWQRESNNDIIGHGTILYRKNIQELDFGTYICTA---GVENFDLKSKKIILAKRIKP-MIRENPDHRASLGRS-VQAKCVIDSIPIANHNQIMWLYRGRRLINDNTKYSISTEKYVDHSISILSINNIQASDFGQYNCSVTTDLGS-ASKVMV 1970
            R F     P A   + + VAP  T  + S     + +END +T +CSA GRP     W    + + V +   S +  +   +     + +C A N    G    D+ ++ V+Y P+      P+    +  G+ +TLTC    NP  ++ W +  +    G G +  +    +   G Y+CTA      N   ++    +  + KP +I   P    +     ++  C+ D  P      + W   G  +   +  YS                N++  S+ G Y C+ T ++GS A+ V V
Sbjct:   98 RTFSSPLSPSASWDLNVKVAPAFTSSLSSSL---DVAENDDVTNTCSASGRPAPNVTWVNKTSGSPVAHGTGSATLSLLKIQRHQAGLYQCQAINDVGRGAITQDVTII-VQYPPEIT----PIQNTTVRAGETITLTCAVAGNPTPSVSWSKAGSGHSTG-GNVFTKAGATKAVTGQYVCTAVNTVTGNTQTRTASTYVMVKYKPSIISSYPGQTVNETIDFLKLTCISDGYPAPT---VTWSRDGLVVSRTSVYYS----------------NSVTRSEAGTYTCTATNEMGSDATTVQV 371

[Close]

BLAST of NEPH-2 vs. Ensembl Nematostella
Match: EDO31942 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7SWF5])

HSP 1 Score: 55.8398 bits (133), Expect = 7.634e-8
Identity = 58/261 (22.22%), Postives = 103/261 (39.46%), Query Frame = 3

Query: 1209 EFSENDWITISCSALGRPD-KFLWKWYINDNEVMNDNRSS-YKIKATRTMNKAVVKCIANN----GKEGHDLRMLNVKYGPQFKDDSPPLYPANI--GDDVTLTCNTDSNPMANIYWQRESNNDIIGHGTILYRKNIQELDFGTYICTA---GVENFDLKSKKIILAKRIKPMIRENPDHRA--SLGRSVQAKCVIDSIPIANHNQIMWLYRGRRLINDNTKYSISTEKYVDHSISILSINNIQASDFGQYNCSVTTDLGS 1952
            + +E+   +I+CSA GRP     W    + + V +   S+   +   +     V +C A N    G    D   +NV+Y P+      P+    +  G+ +TLTC    NP  ++ W +  +    G G +       + + G Y+CTA      N   K+    +  + KP I  N  ++       S++  C+ D  P      + W                S +  V    S+   +++  S+ G Y C+ T ++GS
Sbjct:   13 DVAEDKDFSITCSASGRPAPNVTWVNKTSGSPVAHGTGSAILSLLKIQRHQAGVYQCQATNDVKRGAITQDF-TINVQYPPEIT----PIQNTTVRAGETITLTCAVAGNPTPSVSWSKAGSGQSTG-GNVFNEAGATKAETGQYVCTAVNIVSGNTQTKTVSTYVIVKYKPSIIANSPYQTVNETTGSLKLSCISDGYPAP---MVTW----------------SRDGVVVSPTSVYYSDSVTRSEAGTYTCTATNEMGS 248

HSP 2 Score: 55.0694 bits (131), Expect = 1.223e-7
Identity = 51/200 (25.50%), Postives = 86/200 (43.00%), Query Frame = 3

Query: 1419 VKYGPQFKDDSPPLYPANIGDDVTLTCNTDSNPMANIYWQRESNNDIIGHGTILYRKNIQELDFGTYICTAGVENFDLKSKKIILAKRIKPMIRENPDHRASLGRSVQA-KCVIDSIPIANHNQIMWLYRGRRLINDNTKYSISTEKYVDHSISILSINNIQAS-DFGQYNCSVTTDLGSASKVMVLSK-TSPIPLILIV 2009
            VKY P    +SP          + L+C +D  P   + W R+    ++   ++ Y  ++   + GTY CTA  E     +  + +    KP +  +  + +S  R V + +C    +P+    QI W   G + I         T      S   L +   Q S D+GQY C  +  LGS  +++ +++  SP P I+IV
Sbjct:  174 VKYKPSIIANSPYQTVNETTGSLKLSCISDGYPAPMVTWSRD--GVVVSPTSVYYSDSVTRSEAGTYTCTATNE-MGSDTNTVQVTVNYKPEMASSTTNTSSWNRKVLSLQCKARGVPLP---QITWYKPGGQPI---------TAGVSPISGGQLQVTTTQDSGDYGQYKCRASNLLGSVGRLIYVTQWFSPGPPIIIV 358

[Close]

BLAST of NEPH-2 vs. Ensembl Nematostella
Match: EDO27477 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7T954])

HSP 1 Score: 51.6026 bits (122), Expect = 1.908e-7
Identity = 38/172 (22.09%), Postives = 72/172 (41.86%), Query Frame = 3

Query: 1188 VSQNLGNEFSENDWITISCSALGRPD-KFLWKWYINDNEVMNDNRSSYKIKATRTMNKAVVKCIANNG--KEGHDLRMLNVKYGPQFKDDSPPLYPANIGDDVTLTCNTDSNPMANIYWQRESNNDIIGHGTILYRKNI-----QELDFGTYICTA----GVENFDLKSKKI 1667
            +S ++    +  D +T+ C A G P     W    ++   +  N S   +           +C A+NG  K      +L+V + P+ +      +  ++G  + LTC+ +  P+ ++ W R+ +   I    +  R  +     Q  DFG YIC A    G ++  L  K++
Sbjct:    6 ISPDVSVTINRTDSVTLQCHASGDPAPNITWS---HEGAPLEHNGSILTLYNVTRREAGSYECKADNGIRKPAKASAVLSVNFAPEIERQKKKHFETSLGKAINLTCDVEGGPLPSVTWSRKRSQFSIIFSPVRMRSVLEVIPKQSRDFGDYICMARNIMGWDSHTLTLKRV 174

HSP 2 Score: 49.2914 bits (116), Expect = 1.350e-6
Identity = 43/172 (25.00%), Postives = 72/172 (41.86%), Query Frame = 3

Query: 1470 NIGDDVTLTCNTDSNPMANIYWQRESNNDIIGHGTILYRKNIQELDFGTYICTAGVENFDLKSKKIILAKRIKPMI-RENPDH-RASLGRSVQAKCVIDSIPIANHNQIMWLYRGRRLINDNTKYSISTEKYVDHSISILSINNIQASDFGQYNCSVTTDLGSASKVMVLSK 1979
            N  D VTL C+   +P  NI W  E    +  +G+IL   N+   + G+Y C A            +L+    P I R+   H   SLG+++   C ++  P+ +   + W  +        +++SI          S+L +   Q+ DFG Y C     +G  S  + L +
Sbjct:   15 NRTDSVTLQCHASGDPAPNITWSHE-GAPLEHNGSILTLYNVTRREAGSYECKADNGIRKPAKASAVLSVNFAPEIERQKKKHFETSLGKAINLTCDVEGGPLPS---VTWSRK-------RSQFSIIFSPV--RMRSVLEVIPKQSRDFGDYICMARNIMGWDSHTLTLKR 173

[Close]

BLAST of NEPH-2 vs. Ensembl Medaka
Match: KIRREL3 (kirre like nephrin family adhesion molecule 3 [Source:NCBI gene;Acc:101170290])

HSP 1 Score: 164.466 bits (415), Expect = 2.052e-41
Identity = 133/522 (25.48%), Postives = 229/522 (43.87%), Query Frame = 3

Query:  456 HPENQRVTLNSTVTIQCRVQPIKNMKVYWVKSGFGLGETRSDIRSFGMVGNKVRYDIPNDLSAGNYDLQITDVNLEDEGDFYCQMNIKNNAITSQRAQLHVLVASGPPKIIQIGNQGMGPEKLRNENSPIVVDNGDLMALRCQAERGRPGARLTWMIDNEIIEPDLSGNFNGIISGTITNISKKIVNNTKLRDSFSTLKAKVNQLLNGKSIKCSATNRGFEKFNFPEAKAKIEIHVAPTVTMDIVSQNLGNEFSENDWITISCSALGRPDKFLWKWYINDNEVMNDNRSSYKIKATRTMNKAVVKCIANNGKEGHDL-RMLNVKYGPQFKDDSPPLYPANIGDDVTLTCNTDSNPMANIYWQRESNNDIIGHGTILYRKNIQELDFGTYICTAGVENFDLKSKKIILAKRIKPMIRENPDHRASLGRSVQAKCVIDSIPIANHNQIMWLYRGRRLINDNT-KYSISTEKYVDHSISILSINNIQASDFGQ-YNCSVTTDLGSASKVMVLSKTSPIPLILIVG 2012
             P++  V     VT+ C + P  +  V W+K G  LG  R D+  +       RY +  D  +G + L+I  V L D+  F CQ      A+ S+ A+L VLV    P I      G GP         + +  GD + L C A+  +P A + WM + E++        NG +       SK +V + +   + STL    + +  G+ I C A+N+     N  EA   I+I   P V + +  Q +     E   +   CSA   P   L++W    + +   +  +Y++    +     V C   N     ++ R ++V +GP+   + P     ++G D    C    NP   I W +  +  ++ +  +L  K++++ D G Y+C A V       K++ L     P I      +A  G   Q KC I S P    ++I W ++   L +  + +Y++ T    +  IS L+++NI  +DF   YNC+     GS ++++ L +   +P+ +I+G
Sbjct:   51 QPQDLVVVAGQPVTLPCSI-PGYHGIVLWIKDGLALGVGR-DLSGYP------RYTVIGDHGSGEHHLRIQRVELMDDAVFECQA--VQAAMRSRPARLTVLVPPDDPVI------GGGP--------VVSLRAGDPLNLTCHADNAKPAASIIWMRNGEVL--------NGAM------YSKALVRDGRRESTVSTLYLSPSNIETGQQIICRASNKAVP--NGKEASVTIDIQHLPLVNLSVEPQAV----LEGSLVRFQCSAKANPPVTLYRWAKGGSIIKEVSGDTYEVIVDHSFFTEPVSCEVTNSLGSTNVSRNVDVYFGPRMAAE-PQSLQVDLGSDAVFNCAWTGNPSLTIVWMKRGSGVVLSNENLLTLKSVRQEDAGKYVCRAVVPRVGAGEKEVSLTVNGPPTISSTQTQQALHGEKGQIKCFIRSTPPP--DRIAWSWKETVLESGTSGRYTVETVNTEEGVISTLTMSNIVPADFQTIYNCTAWNSFGSDTEIIRLKEQESLPVAVIIG 525

[Close]

BLAST of NEPH-2 vs. Ensembl Medaka
Match: KIRREL3 (kirre like nephrin family adhesion molecule 3 [Source:NCBI gene;Acc:101170290])

HSP 1 Score: 164.081 bits (414), Expect = 4.539e-41
Identity = 133/522 (25.48%), Postives = 229/522 (43.87%), Query Frame = 3

Query:  456 HPENQRVTLNSTVTIQCRVQPIKNMKVYWVKSGFGLGETRSDIRSFGMVGNKVRYDIPNDLSAGNYDLQITDVNLEDEGDFYCQMNIKNNAITSQRAQLHVLVASGPPKIIQIGNQGMGPEKLRNENSPIVVDNGDLMALRCQAERGRPGARLTWMIDNEIIEPDLSGNFNGIISGTITNISKKIVNNTKLRDSFSTLKAKVNQLLNGKSIKCSATNRGFEKFNFPEAKAKIEIHVAPTVTMDIVSQNLGNEFSENDWITISCSALGRPDKFLWKWYINDNEVMNDNRSSYKIKATRTMNKAVVKCIANNGKEGHDL-RMLNVKYGPQFKDDSPPLYPANIGDDVTLTCNTDSNPMANIYWQRESNNDIIGHGTILYRKNIQELDFGTYICTAGVENFDLKSKKIILAKRIKPMIRENPDHRASLGRSVQAKCVIDSIPIANHNQIMWLYRGRRLINDNT-KYSISTEKYVDHSISILSINNIQASDFGQ-YNCSVTTDLGSASKVMVLSKTSPIPLILIVG 2012
             P++  V     VT+ C + P  +  V W+K G  LG  R D+  +       RY +  D  +G + L+I  V L D+  F CQ      A+ S+ A+L VLV    P I      G GP         + +  GD + L C A+  +P A + WM + E++        NG +       SK +V + +   + STL    + +  G+ I C A+N+     N  EA   I+I   P V + +  Q +     E   +   CSA   P   L++W    + +   +  +Y++    +     V C   N     ++ R ++V +GP+   + P     ++G D    C    NP   I W +  +  ++ +  +L  K++++ D G Y+C A V       K++ L     P I      +A  G   Q KC I S P    ++I W ++   L +  + +Y++ T    +  IS L+++NI  +DF   YNC+     GS ++++ L +   +P+ +I+G
Sbjct:   93 QPQDLVVVAGQPVTLPCSI-PGYHGIVLWIKDGLALGVGR-DLSGYP------RYTVIGDHGSGEHHLRIQRVELMDDAVFECQA--VQAAMRSRPARLTVLVPPDDPVI------GGGP--------VVSLRAGDPLNLTCHADNAKPAASIIWMRNGEVL--------NGAM------YSKALVRDGRRESTVSTLYLSPSNIETGQQIICRASNKAVP--NGKEASVTIDIQHLPLVNLSVEPQAV----LEGSLVRFQCSAKANPPVTLYRWAKGGSIIKEVSGDTYEVIVDHSFFTEPVSCEVTNSLGSTNVSRNVDVYFGPRMAAE-PQSLQVDLGSDAVFNCAWTGNPSLTIVWMKRGSGVVLSNENLLTLKSVRQEDAGKYVCRAVVPRVGAGEKEVSLTVNGPPTISSTQTQQALHGEKGQIKCFIRSTPPP--DRIAWSWKETVLESGTSGRYTVETVNTEEGVISTLTMSNIVPADFQTIYNCTAWNSFGSDTEIIRLKEQESLPVAVIIG 567

[Close]

BLAST of NEPH-2 vs. Ensembl Medaka
Match: KIRREL3 (kirre like nephrin family adhesion molecule 3 [Source:NCBI gene;Acc:101170290])

HSP 1 Score: 162.925 bits (411), Expect = 6.677e-41
Identity = 131/522 (25.10%), Postives = 230/522 (44.06%), Query Frame = 3

Query:  456 HPENQRVTLNSTVTIQCRVQPIKNMKVYWVKSGFGLGETRSDIRSFGMVGNKVRYDIPNDLSAGNYDLQITDVNLEDEGDFYCQMNIKNNAITSQRAQLHVLVASGPPKIIQIGNQGMGPEKLRNENSPIVVDNGDLMALRCQAERGRPGARLTWMIDNEIIEPDLSGNFNGIISGTITNISKKIVNNTKLRDSFSTLKAKVNQLLNGKSIKCSATNRGFEKFNFPEAKAKIEIHVAPTVTMDIVSQNLGNEFSENDWITISCSALGRPDKFLWKWYINDNEVMNDNRSSYKIKATRTMNKAVVKCIANNGKEGHDL-RMLNVKYGPQFKDDSPPLYPANIGDDVTLTCNTDSNPMANIYWQRESNNDIIGHGTILYRKNIQELDFGTYICTAGVENFDLKSKKIILAKRIKPMIRENPDHRASLGRSVQAKCVIDSIPIANHNQIMWLYRGRRLINDNT-KYSISTEKYVDHSISILSINNIQASDFGQ-YNCSVTTDLGSASKVMVLSKTSPIPLILIVG 2012
             P++  V     VT+ C + P  +  V W+K G  LG  R D+  +       RY +  D  +G + L+I  V L D+  F CQ      A+ S+ A+L VLV    P I      G GP         + +  GD + L C A+  +P A + WM + E++        NG +   ++   + +V + +   + STL    + +  G+ I C A+N+     N  EA   I+I   P V + +  Q +     E   +   CSA   P   L++W    + +   +  +Y++    +     V C   N     ++ R ++V +GP+   + P     ++G D    C    NP   I W +  +  ++ +  +L  K++++ D G Y+C A V       K++ L     P I      +A  G   Q KC I S P    ++I W ++   L +  + +Y++ T    +  IS L+++NI  +DF   YNC+     GS ++++ L +   +P+ +I+G
Sbjct:   23 QPQDLVVVAGQPVTLPCSI-PGYHGIVLWIKDGLALGVGR-DLSGYP------RYTVIGDHGSGEHHLRIQRVELMDDAVFECQA--VQAAMRSRPARLTVLVPPDDPVI------GGGP--------VVSLRAGDPLNLTCHADNAKPAASIIWMRNGEVL--------NGAMYSKVS--IEALVRDGRRESTVSTLYLSPSNIETGQQIICRASNKAVP--NGKEASVTIDIQHLPLVNLSVEPQAV----LEGSLVRFQCSAKANPPVTLYRWAKGGSIIKEVSGDTYEVIVDHSFFTEPVSCEVTNSLGSTNVSRNVDVYFGPRMAAE-PQSLQVDLGSDAVFNCAWTGNPSLTIVWMKRGSGVVLSNENLLTLKSVRQEDAGKYVCRAVVPRVGAGEKEVSLTVNGPPTISSTQTQQALHGEKGQIKCFIRSTPPP--DRIAWSWKETVLESGTSGRYTVETVNTEEGVISTLTMSNIVPADFQTIYNCTAWNSFGSDTEIIRLKEQESLPVAVIIG 501

[Close]

BLAST of NEPH-2 vs. Ensembl Medaka
Match: KIRREL3 (kirre like nephrin family adhesion molecule 3 [Source:NCBI gene;Acc:101170290])

HSP 1 Score: 159.073 bits (401), Expect = 1.173e-39
Identity = 133/526 (25.29%), Postives = 229/526 (43.54%), Query Frame = 3

Query:  456 HPENQRVTLNSTVTIQCRVQPIKNMKVYWVKSGFGLGETRSDIRSFGMVGNKVRYDIPNDLSAGNYDLQITDVNLEDEGDFYCQMNIKNNAITSQRAQLHVLVASGPPKIIQIGNQGMGPEKLRNENSPIVVDNGDLMALRCQAERGRPGARLTWMIDNEIIEPDLSGNFNGIISGTITNISKKIVNNTKLRDSFSTLKAKVNQLLNGKSIKCSATNRGFEKFNFPEAKAKIEIHVAPTVTMDIVSQNLGNEFSENDWITISCSALGRPDKFLWKWYINDNEVMNDNRSSYKIKATRTMNKAVVKCIANNGKEGHDL-RMLNVKYGPQFKDDSPPLYPANIGDDVTLTCNTDSNPMANIYWQRESNNDIIGHGTILYRKNIQELDFGTYICTAGVENFDLKSKKIILAKRIKPMIRENPDHRASLGRSVQAKCVIDSIPIANHNQIMWLYRGRRLINDNT-KYSISTEKYVDHSISILSINNIQASDFGQ-YNCSVTTDLGSASKVMVLSK----TSPIPLILIVG 2012
             P++  V     VT+ C + P  +  V W+K G  LG  R D+  +       RY +  D  +G + L+I  V L D+  F CQ      A+ S+ A+L VLV    P I      G GP         + +  GD + L C A+  +P A + WM + E++        NG +       SK +V + +   + STL    + +  G+ I C A+N+     N  EA   I+I   P V + +  Q +     E   +   CSA   P   L++W    + +   +  +Y++    +     V C   N     ++ R ++V +GP+   + P     ++G D    C    NP   I W +  +  ++ +  +L  K++++ D G Y+C A V       K++ L     P I      +A  G   Q KC I S P    ++I W ++   L +  + +Y++ T    +  IS L+++NI  +DF   YNC+     GS ++++ L +       +P+ +I+G
Sbjct:   19 QPQDLVVVAGQPVTLPCSI-PGYHGIVLWIKDGLALGVGR-DLSGYP------RYTVIGDHGSGEHHLRIQRVELMDDAVFECQA--VQAAMRSRPARLTVLVPPDDPVI------GGGP--------VVSLRAGDPLNLTCHADNAKPAASIIWMRNGEVL--------NGAM------YSKALVRDGRRESTVSTLYLSPSNIETGQQIICRASNKAVP--NGKEASVTIDIQHLPLVNLSVEPQAV----LEGSLVRFQCSAKANPPVTLYRWAKGGSIIKEVSGDTYEVIVDHSFFTEPVSCEVTNSLGSTNVSRNVDVYFGPRMAAE-PQSLQVDLGSDAVFNCAWTGNPSLTIVWMKRGSGVVLSNENLLTLKSVRQEDAGKYVCRAVVPRVGAGEKEVSLTVNGPPTISSTQTQQALHGEKGQIKCFIRSTPPP--DRIAWSWKETVLESGTSGRYTVETVNTEEGVISTLTMSNIVPADFQTIYNCTAWNSFGSDTEIIRLKEQGGSQESLPVAVIIG 497

[Close]

BLAST of NEPH-2 vs. Ensembl Medaka
Match: kirrel1a (kin of IRRE-like protein 1 [Source:NCBI gene;Acc:101168819])

HSP 1 Score: 144.05 bits (362), Expect = 9.116e-35
Identity = 127/532 (23.87%), Postives = 223/532 (41.92%), Query Frame = 3

Query:  456 HPENQRVTLNSTVTIQCRVQPIKNMKVYWVKSGFGLGETRSDIRSFGMVGNKVRYDIPNDLSAGNYDLQITDVNLEDEGDFYCQMNIKNNAITSQRAQLHVLVASGPPKIIQIGNQGMGPEKLRNENSPIVVDNGDLMALRCQAERGRPGARLTWMIDNEIIEPDLSGNFNGIISGTITNISKKIVNNTKLRDSFSTLKAKVNQLLNGKSIKCSATNRGFEKFNFPEAKAK---IEIHVAPTVTMDIVSQNLGNEFSENDWITISCSALGRPDKFLWKWYINDNEVMNDNRSSYKIKATRTMNKAVVKCIANNGKEGHDLRML-NVKYGPQFKDDSPPLYPANIGDDVTLTCNTDSNPMANIYWQRESNNDIIGHGTILYRKNIQELDFGTYICTAGVENFDLKSKKIILAKRIKPMIRENPDHRASLGRSVQAKCVIDSIPIANHNQIMWLYRGRRLIND----NTKYSISTEKYVDHS---ISILSINNIQASDF-GQYNCSVTTDLGSASKVMVLSKTSPIPLILIVGG 2015
             P +Q V     V + C V     + V W K G  LG    D+R++       RY +     +G Y+L+I   +L D+  + CQ    + A+ S+RA+L VL+    P I        GPE L N         G+   L C +   +P + + W+ D   +E        G +S T      +++ + K   + S L         G++  C  +N        P  K+    + +H  P VT+ I  +++     E D +T +C A   P    ++W      +     S +  KA  +     V C+  N     ++ +L +V++GP    +  P    ++  DVTL C    NP   + W ++ +N ++ +   LY +++ + D G Y+C A V    +   ++ L     P+I  +P   A  G   + KC I S P    ++I+W ++      +      +Y++   K        +S L+INN+  SDF   YNC+     G  + ++ L +   +P+ +I  G
Sbjct:   21 EPADQSVVRGQRVILSCVVFNYSGI-VQWTKDGLALG-IGEDLRAW------PRYRVLRVQESGQYNLEILSADLSDDAVYECQA--PDAALRSRRAKLTVLIPPDDPVI------DGGPEVLLNA--------GESYNLSCVSRGAKPPSTIEWLKDGLPVE--------GAVSIT------EVLADRKRVTTQSHLPIHPVDTDTGRNYSCVTSN-----LAVPSGKSTTVTLNVHHPPVVTLSIEPRSV----LEGDRVTFTCQAHANPPIMGYRWAKGGVVLQGARESVFTTKADHSFFTEPVSCLVFNAVGKTNVSILVDVQFGPILLVEPQPKT-VDVNSDVTLNCKWAGNPPLTLTWFKKGSNMVLSNSNQLYLQSVSQADAGQYVCKAIVPRIGVGETEVTLTVNGPPIISSDPVQYAVRGERGEVKCYIASTPPP--DKIVWAWKENVWEKERGTLQERYTVEQSKLSAEGGGVLSTLTINNVMESDFLSTYNCTAWNSFGPGTMIITLEEKEEVPVGIIAVG 502

[Close]

BLAST of NEPH-2 vs. Planmine SMEST
Match: SMESG000071657.1 (SMESG000071657.1)

HSP 1 Score: 1707.58 bits (4421), Expect = 0.000e+0
Identity = 842/842 (100.00%), Postives = 842/842 (100.00%), Query Frame = 3

Query:  432 GNENYINVHPENQRVTLNSTVTIQCRVQPIKNMKVYWVKSGFGLGETRSDIRSFGMVGNKVRYDIPNDLSAGNYDLQITDVNLEDEGDFYCQMNIKNNAITSQRAQLHVLVASGPPKIIQIGNQGMGPEKLRNENSPIVVDNGDLMALRCQAERGRPGARLTWMIDNEIIEPDLSGNFNGIISGTITNISKKIVNNTKLRDSFSTLKAKVNQLLNGKSIKCSATNRGFEKFNFPEAKAKIEIHVAPTVTMDIVSQNLGNEFSENDWITISCSALGRPDKFLWKWYINDNEVMNDNRSSYKIKATRTMNKAVVKCIANNGKEGHDLRMLNVKYGPQFKDDSPPLYPANIGDDVTLTCNTDSNPMANIYWQRESNNDIIGHGTILYRKNIQELDFGTYICTAGVENFDLKSKKIILAKRIKPMIRENPDHRASLGRSVQAKCVIDSIPIANHNQIMWLYRGRRLINDNTKYSISTEKYVDHSISILSINNIQASDFGQYNCSVTTDLGSASKVMVLSKTSPIPLILIVGGXXXXXXXXXXXXXALCVCKRGICSNKYQKGSPTNRINSNNSTDPLKSPQFEMDYQCQPNFFQWIPNNNREQVKSSFVRYGQDVDDRSSIRNGSINQYRGLDMCSTYTSSIPGSQNGEKPIRNPDIDDVYKEEFYPSSNPAMMCSMHITPTGSGAINRASPCNAHPYSVPQHQISLPQYNFTSFANPPYLSNYLPGSNNNFALPSYPVHSPSSEPGINGGSGLMIPPVLPPIDTNDANHNVELGLSPQQTSFIKPGMTISQNMANYLSPNIRPKPNSYNYTLSGNSNDGNSFKSRTLDRRGPISSFTNVDQTTNI 2957
            GNENYINVHPENQRVTLNSTVTIQCRVQPIKNMKVYWVKSGFGLGETRSDIRSFGMVGNKVRYDIPNDLSAGNYDLQITDVNLEDEGDFYCQMNIKNNAITSQRAQLHVLVASGPPKIIQIGNQGMGPEKLRNENSPIVVDNGDLMALRCQAERGRPGARLTWMIDNEIIEPDLSGNFNGIISGTITNISKKIVNNTKLRDSFSTLKAKVNQLLNGKSIKCSATNRGFEKFNFPEAKAKIEIHVAPTVTMDIVSQNLGNEFSENDWITISCSALGRPDKFLWKWYINDNEVMNDNRSSYKIKATRTMNKAVVKCIANNGKEGHDLRMLNVKYGPQFKDDSPPLYPANIGDDVTLTCNTDSNPMANIYWQRESNNDIIGHGTILYRKNIQELDFGTYICTAGVENFDLKSKKIILAKRIKPMIRENPDHRASLGRSVQAKCVIDSIPIANHNQIMWLYRGRRLINDNTKYSISTEKYVDHSISILSINNIQASDFGQYNCSVTTDLGSASKVMVLSKTSPIPLILIVGGTVFITMVMMIVIIALCVCKRGICSNKYQKGSPTNRINSNNSTDPLKSPQFEMDYQCQPNFFQWIPNNNREQVKSSFVRYGQDVDDRSSIRNGSINQYRGLDMCSTYTSSIPGSQNGEKPIRNPDIDDVYKEEFYPSSNPAMMCSMHITPTGSGAINRASPCNAHPYSVPQHQISLPQYNFTSFANPPYLSNYLPGSNNNFALPSYPVHSPSSEPGINGGSGLMIPPVLPPIDTNDANHNVELGLSPQQTSFIKPGMTISQNMANYLSPNIRPKPNSYNYTLSGNSNDGNSFKSRTLDRRGPISSFTNVDQTTNI
Sbjct:   17 GNENYINVHPENQRVTLNSTVTIQCRVQPIKNMKVYWVKSGFGLGETRSDIRSFGMVGNKVRYDIPNDLSAGNYDLQITDVNLEDEGDFYCQMNIKNNAITSQRAQLHVLVASGPPKIIQIGNQGMGPEKLRNENSPIVVDNGDLMALRCQAERGRPGARLTWMIDNEIIEPDLSGNFNGIISGTITNISKKIVNNTKLRDSFSTLKAKVNQLLNGKSIKCSATNRGFEKFNFPEAKAKIEIHVAPTVTMDIVSQNLGNEFSENDWITISCSALGRPDKFLWKWYINDNEVMNDNRSSYKIKATRTMNKAVVKCIANNGKEGHDLRMLNVKYGPQFKDDSPPLYPANIGDDVTLTCNTDSNPMANIYWQRESNNDIIGHGTILYRKNIQELDFGTYICTAGVENFDLKSKKIILAKRIKPMIRENPDHRASLGRSVQAKCVIDSIPIANHNQIMWLYRGRRLINDNTKYSISTEKYVDHSISILSINNIQASDFGQYNCSVTTDLGSASKVMVLSKTSPIPLILIVGGTVFITMVMMIVIIALCVCKRGICSNKYQKGSPTNRINSNNSTDPLKSPQFEMDYQCQPNFFQWIPNNNREQVKSSFVRYGQDVDDRSSIRNGSINQYRGLDMCSTYTSSIPGSQNGEKPIRNPDIDDVYKEEFYPSSNPAMMCSMHITPTGSGAINRASPCNAHPYSVPQHQISLPQYNFTSFANPPYLSNYLPGSNNNFALPSYPVHSPSSEPGINGGSGLMIPPVLPPIDTNDANHNVELGLSPQQTSFIKPGMTISQNMANYLSPNIRPKPNSYNYTLSGNSNDGNSFKSRTLDRRGPISSFTNVDQTTNI 858

[Close]

BLAST of NEPH-2 vs. Planmine SMEST
Match: SMESG000022777.1 (SMESG000022777.1)

HSP 1 Score: 434.491 bits (1116), Expect = 4.489e-138
Identity = 273/811 (33.66%), Postives = 434/811 (53.51%), Query Frame = 3

Query:  438 ENYINVHPENQRVTLNSTVTIQCRVQPIKNMKVYWVKSGFGLGETRSDIRSFGMVG-NKVRYDIPNDLSAGNYDLQITDVNLEDEGDFYCQMNIKNNAITSQRAQLHVLVASGPPKIIQIGNQGMGPEKLRNENSPIVVDNGDLMALRCQAERGRPGARLTWMIDNEIIEPDLSGNFN-GIISGTITNISKKIVNNTKLRDSFSTLKAKVNQLLNGKSIKCSATNRGFEKFNFPEAKAKIEIHVAPTVTMDIVSQNLGNEFSENDWITISCSALGRPDKFLWKWYINDNEVMNDNRSSYKIKATRTMNKAVVKCIANNGKEGHDLRMLNVKYGPQFKD-DSPPLYPANIGDDVTLTCNTDSNPMANIYWQRESNNDIIGHGTILYRKNIQELDFGTYICTAGVENFDLKSKKIILAKRIKPMIRENPDHRASLGRSVQAKCVIDSIPIANHNQIMWLYRGRRLINDNTKYSISTEKYVDHSISILSINNIQASDFGQYNCSVTTDLGSASKVMVLSKTSPIPLILIVGGXXXXXXXXXXXXXALCVCKRGICSNKYQKGSPTN-RINSNNSTDPLKSPQFEMDYQCQPNFFQWIPNNNREQVKSSFVRYGQDVDDRSSIRNGSINQYRGLDMCSTYTSSIPGSQNGEKPIRNPDIDDVYKEEFYPSSNPAMMCSMHITPTGSGAINRAS----------PCNAHPYSVPQHQISLPQYNFTSFANPPYLSNYLPGSNNNFALPSYPVHSPSSEPGINGGSGLMIPPVLPPIDTNDANHNVELGLSPQQTSFIKPGMTISQNMANYLSPNIR 2828
            ++YI VHPE Q   LNST+T++CRV+ ++  +V+WVK GFGLG +R+DIR +G    ++ R+D+P +L+ G YDL+ITD+ L DEG FYCQ+ +   A +SQ+  + VLV S  P+++QI    +GP+ +RNE +PI+V++G+ + ++C A+ GRPGA L W ++   IE   +G  N   ++G IT  S+   N  KL D  ++L+ K+  L NG  +KC A N G+         A+I ++  P V +++  +   N F END +  +CSA GRP  F W W I D  ++N     YK+K TR  +   + C A +   G +   + VKYGP FKD DS  +Y A+IG+++ + C  D NP   I WQR S+N++I  G+IL R +IQ  DFG YIC A V+ F  + K I L ++  P I+         G+S +  C I SIP  N N+I W+++ ++L+ + T++ +  +       S+L I ++Q  DFG YNCSV+T  GS    ++L + S  P+++IVG T+    +++++I+ LC+C+R    ++Y KG+P++  I  ++     KS   + D QC PN + WIP       +S  V+   DV  +   ++G+       ++ S Y++S+P SQ+  K ++      + K E   ++NP ++ +MH    G+  +NR S          P    P      Q +  QY + +  NP    N       + A P Y V  P+++                        H ++      QT F  PG  I +N  N  S N+ 
Sbjct:   17 DDYILVHPERQVAALNSTITLKCRVKVVEKYEVHWVKDGFGLGNSRTDIRQYGQRKPHQFRFDLPFNLAEGEYDLRITDLELFDEGVFYCQIVVNGKAYSSQKVLVQVLVPSDKPQLVQINK--IGPQAIRNEKNPIIVNDGEYLHIKCIAKHGRPGASLYWYLNEIKIEAQKNGVLNETFLNGKITITSESSENLPKLYDVVNSLELKIVSLKNGNWLKCLAINNGYTNQKLNYTSAQIVVYTVPIVVINVYPKKQNNIFIENDIVEFTCSASGRPSDFHWAWTIGDESLVNIRDPKYKLKITRVDHGKKITCCATSKSIGCNSTNILVKYGPNFKDSDSLTIYAASIGENMQMECRADGNPEPLITWQRISSNEVIARGSILLRNDIQADDFGDYICKAAVKEFPERHKYIYLGEKGPPEIKNPSVSYGREGQSARLSCTIKSIPFPNDNEIKWIFKNKQLL-EGTRHKMYRQINEKIVTSVLHILSVQPHDFGDYNCSVSTKYGSDMATIILLRKSETPMLMIVGATIIFLFILLVIIVVLCICQRRKFKDEYMKGNPSSPEIPLHHEA---KSTLIDSDCQCNPNLYSWIP-------QSFDVKSQNDVLSKIHYQDGNFWP-NSQEIESCYSNSVPDSQSSNKSVK------ITKHE-NANTNP-ILYNMHT--IGTNTLNRYSTNMPFTNLPIPREKDPRFCDSSQCT--QYLYQNLYNPVVEHNSQLNPTESTASPIYIVKKPANK-----------------------KHQIQF-----QTDFYSPGKPIIKNKLNSGSANME 773

[Close]

BLAST of NEPH-2 vs. Planmine SMEST
Match: SMESG000022777.1 (SMESG000022777.1)

HSP 1 Score: 434.106 bits (1115), Expect = 6.973e-138
Identity = 273/811 (33.66%), Postives = 434/811 (53.51%), Query Frame = 3

Query:  438 ENYINVHPENQRVTLNSTVTIQCRVQPIKNMKVYWVKSGFGLGETRSDIRSFGMVG-NKVRYDIPNDLSAGNYDLQITDVNLEDEGDFYCQMNIKNNAITSQRAQLHVLVASGPPKIIQIGNQGMGPEKLRNENSPIVVDNGDLMALRCQAERGRPGARLTWMIDNEIIEPDLSGNFN-GIISGTITNISKKIVNNTKLRDSFSTLKAKVNQLLNGKSIKCSATNRGFEKFNFPEAKAKIEIHVAPTVTMDIVSQNLGNEFSENDWITISCSALGRPDKFLWKWYINDNEVMNDNRSSYKIKATRTMNKAVVKCIANNGKEGHDLRMLNVKYGPQFKD-DSPPLYPANIGDDVTLTCNTDSNPMANIYWQRESNNDIIGHGTILYRKNIQELDFGTYICTAGVENFDLKSKKIILAKRIKPMIRENPDHRASLGRSVQAKCVIDSIPIANHNQIMWLYRGRRLINDNTKYSISTEKYVDHSISILSINNIQASDFGQYNCSVTTDLGSASKVMVLSKTSPIPLILIVGGXXXXXXXXXXXXXALCVCKRGICSNKYQKGSPTN-RINSNNSTDPLKSPQFEMDYQCQPNFFQWIPNNNREQVKSSFVRYGQDVDDRSSIRNGSINQYRGLDMCSTYTSSIPGSQNGEKPIRNPDIDDVYKEEFYPSSNPAMMCSMHITPTGSGAINRAS----------PCNAHPYSVPQHQISLPQYNFTSFANPPYLSNYLPGSNNNFALPSYPVHSPSSEPGINGGSGLMIPPVLPPIDTNDANHNVELGLSPQQTSFIKPGMTISQNMANYLSPNIR 2828
            ++YI VHPE Q   LNST+T++CRV+ ++  +V+WVK GFGLG +R+DIR +G    ++ R+D+P +L+ G YDL+ITD+ L DEG FYCQ+ +   A +SQ+  + VLV S  P+++QI    +GP+ +RNE +PI+V++G+ + ++C A+ GRPGA L W ++   IE   +G  N   ++G IT  S+   N  KL D  ++L+ K+  L NG  +KC A N G+         A+I ++  P V +++  +   N F END +  +CSA GRP  F W W I D  ++N     YK+K TR  +   + C A +   G +   + VKYGP FKD DS  +Y A+IG+++ + C  D NP   I WQR S+N++I  G+IL R +IQ  DFG YIC A V+ F  + K I L ++  P I+         G+S +  C I SIP  N N+I W+++ ++L+ + T++ +  +       S+L I ++Q  DFG YNCSV+T  GS    ++L + S  P+++IVG T+    +++++I+ LC+C+R    ++Y KG+P++  I  ++     KS   + D QC PN + WIP       +S  V+   DV  +   ++G+       ++ S Y++S+P SQ+  K ++      + K E   ++NP ++ +MH    G+  +NR S          P    P      Q +  QY + +  NP    N       + A P Y V  P+++                        H ++      QT F  PG  I +N  N  S N+ 
Sbjct:   20 DDYILVHPERQVAALNSTITLKCRVKVVEKYEVHWVKDGFGLGNSRTDIRQYGQRKPHQFRFDLPFNLAEGEYDLRITDLELFDEGVFYCQIVVNGKAYSSQKVLVQVLVPSDKPQLVQINK--IGPQAIRNEKNPIIVNDGEYLHIKCIAKHGRPGASLYWYLNEIKIEAQKNGVLNETFLNGKITITSESSENLPKLYDVVNSLELKIVSLKNGNWLKCLAINNGYTNQKLNYTSAQIVVYTVPIVVINVYPKKQNNIFIENDIVEFTCSASGRPSDFHWAWTIGDESLVNIRDPKYKLKITRVDHGKKITCCATSKSIGCNSTNILVKYGPNFKDSDSLTIYAASIGENMQMECRADGNPEPLITWQRISSNEVIARGSILLRNDIQADDFGDYICKAAVKEFPERHKYIYLGEKGPPEIKNPSVSYGREGQSARLSCTIKSIPFPNDNEIKWIFKNKQLL-EGTRHKMYRQINEKIVTSVLHILSVQPHDFGDYNCSVSTKYGSDMATIILLRKSETPMLMIVGATIIFLFILLVIIVVLCICQRRKFKDEYMKGNPSSPEIPLHHEA---KSTLIDSDCQCNPNLYSWIP-------QSFDVKSQNDVLSKIHYQDGNFWP-NSQEIESCYSNSVPDSQSSNKSVK------ITKHE-NANTNP-ILYNMHT--IGTNTLNRYSTNMPFTNLPIPREKDPRFCDSSQCT--QYLYQNLYNPVVEHNSQLNPTESTASPIYIVKKPANK-----------------------KHQIQF-----QTDFYSPGKPIIKNKLNSGSANME 776

[Close]

BLAST of NEPH-2 vs. Planmine SMEST
Match: SMESG000074081.1 (SMESG000074081.1)

HSP 1 Score: 162.925 bits (411), Expect = 1.053e-40
Identity = 167/643 (25.97%), Postives = 260/643 (40.44%), Query Frame = 3

Query:  459 PENQRVTLNSTVTIQCRVQ------PIKNMKVYWVKSGFGL-GETRSDIRSFGMVGNKVRYDIPNDLSAGNYDLQITDVNLEDEGDFYCQMNIKNNAI-TSQRAQLHVLVASGPPKIIQIGNQGMGPEKLRNENSPIVVDNGDL---MALRCQAERGRPGARLTWMIDNEIIEPDLSGNFNGIISGTITNISKKIVNNTKLRDSF--------STLKAKVNQLLNGKSIKCSATNRGFEKFNFPE-AKAKIEIHVAPTVTMDIVSQNLGNEFSENDWITISCSALGRPDKFLWKWYINDNEVMNDNRSSY-------KIKATRTMNKAVVKC--------------------IANNG----------KEGHDLRMLNVKYGPQFKDDSPPLYPANIGDDVTLTCNTDSNPMANIYWQRE--------SNNDIIG--------------HGTIL-----YRKNIQELD-FGTYICTAGVENFDLKSKKIILAKRIKPMIRENPD-HRASLGRSVQAKCVIDSIPIANHNQIMWLYR-GRRLINDNTKYSISTEKYVDHSISILSINNIQASDFGQYNCSVTTDLGSASKVMVLSKTSPIPLILIVGGXXXXXXXXXXXXXALCVCK----RGICSNK---YQKG 2105
            P +  V +NST  ++CRV       P+K   V W K GFG   ET  D           RY +P     G YDL I  V+ +D+G++ CQ+N   + + T++   L V+V   PP  I++ +     +     N  I    G L   + L C+ +  RP   L W +    +    SG+ +G   GT+T         ++  DSF        S L+ ++ +  NG+ +KC+  N        P+ A  K+ +     V MD++       F+E++ I I+CSA   P   ++ W   +          Y       KIK  R +N   ++C                    I +N             G    +L V+Y P   D       A +GD VTL C  DSNP A I W +         +N D++G                T+L     Y   I + D  G +IC A  + F    K + + +   P I  N     A  G SV+  C I SIP+ +  +I+W      + I   +K  I  E+ +   +S L I+ +   D+G YNCSV+   G  S  + L      P+I I+G +  I + ++   I  C+ +    R   +N+   Y KG
Sbjct:   36 PVSTSVLINSTARLRCRVTFNNSNTPVK---VQWQKDGFGYENETLRD-------HFNGRYQMPGPRETGTYDLVIHSVDKQDDGEYACQVNAAIHILETTKSINLTVIV---PPDKIKLKSSQFDFQNNSTNNEIIQNIWGHLNEFLILSCEIQYSRPATELVWKLGEFALREGKSGDIDGQEVGTVT-------TKSEFMDSFDQFYYKSESHLRLRLRKDHNGEILKCTIANEQSFMHKTPKPAIMKLNVLFVLDVKMDVIPHRPFFHFTEHEMIQINCSASTNPANVIYNWIKYNPTTKTTTIIKYFDRSGVLKIKVRRDLNNMFIRCQVLSVLAGQECYSNFQPESIIYDNSYLVNCSERHTANGSSQIILRVQYSPIILDSILETKAAFLGDVVTLDCRADSNPPAKITWYKSKFSSKEIMANPDLVGARNLQKDTQMSSYSSMTLLSISDKYHFTITDADNLGLFICIALTDGFPPVQKTVFVGQGATPQIVNNQKIIIAKSGLSVRISCHIISIPLPDKGKIIWFKNLNTKPIEAKSKNQIYEEERLAGVVSYLYIHKVTYEDYGTYNCSVSNPYGRVSSTIELIPPVETPMIFIIGSSCAIALAVLFAFIIFCIIRTSKNRSTSTNQRSVYMKG 658

[Close]

BLAST of NEPH-2 vs. Planmine SMEST
Match: SMESG000077979.1 (SMESG000077979.1)

HSP 1 Score: 109.383 bits (272), Expect = 5.441e-24
Identity = 137/636 (21.54%), Postives = 246/636 (38.68%), Query Frame = 3

Query:  456 HPENQRVTLNSTVTIQCRVQPIKN---MKVYWVKSGFGL-GETRSDIRSFGMVGNKVRYDIPNDLSAGNYDLQITDVNLEDEGDFYC--QMNIKNNAITSQRAQLHVLVASGPPKIIQ----------IGNQGMGPEKLRNENSPIVVDNGDLMALRCQAERGRPGARLTWMIDNEIIEPDLSGNFNGIISGTITNISKKIVNNTKLRDSFSTLKAKVNQLLNGKSIKCSATNRG-FEKFNFPEAKAKIEIHVAPTVTMDIVSQNLGNEFSENDWITISCSALGRPDKFL-WKWYINDNEVMNDN------RSSYK---IKATRTMNKAVVKCIANNGKEGH------------DLRM-------LNVKYGPQFKDDSPPLYPANIGDDVTLTCNTDSNPMANIYWQR----ESNN----------------------DIIGHGTILYRKNIQELDFGTYICTAGVENFDLKSKKIILAKRIKPMIR-ENPDHRASLGRSVQAKCVIDSIPIANHNQIMWLYRGRRL--INDNTKYSISTEKYVDHSISILSINNIQASDFGQYNCSVTTDLGSASKVMVLSKTSPIPL-----ILIVGGXXXXXXXXXXXXXALCVCKRGICSNKYQKGSPTNRI 2123
             P   +V L     ++CR++  +N   +K+ W K  FGL   T  D+        K R  IP  + +G YDL      L+DE  + C  ++ ++++ I      +  L+  G  KII+          + N        +  +S I V     +   C ++ G P  +L W +  E    D     NG I                 R ++S ++   +   +  +I C   N+  +     P A   +++       +   + N+       + ++ SC+++  P   + + W++  N V   N      RSS     IKA+   + + + C+     +              +LR        LN+ Y P+ K     +   NIG+ V L+C  DSNP A+I W +     S N                      ++I   +    + + E D   YIC A    F    K +++AK+ +P I+ E    +          C+++S P  + + I W +    L  I+   +Y I+  + +    S L    +  SD+G Y CS      S  K +V  +   +PL     I I  G + + ++++I +  +C CK+G    +  K +P  +I
Sbjct:   32 EPSEVKVILGQPTVLKCRLEIPENVVKIKLQWSKDMFGLENSTIQDVY-------KGRLTIPGSIQSGYYDLHFKTTELQDEALYGCHIELTLRDSEI------VESLIGKGSLKIIEPPTELGFQFHVANASYSGIIWQKRDSIIWVPENQKLNFTCISKNGSPMPQLMWTVKTETGLSD-----NGKIQ----------------RQNYSLMRLSSD--FHNSNISCKIVNKKDYLDGKLPTAVVTVQVLYIKNAVILRTNGNIDKPIHNGEAVSFSCNSIFTPGIIIYYSWFVEYNNVEKQNGEYLVERSSSNNIVIKASPKFHFSRLHCMLFTSVQKDNCDSNINRNCNIELRHKAVSSKSLNILYPPKIKTPFENITVTNIGEWVVLSCEVDSNPQASIRWYKTHFGTSKNTRSINWYYQTSTINLNEVTVIENMISSTSYHKFQVVNEYDLDIYICEAQASTFQKIYKYVVVAKKEEPTIKVEQATIKVENDGIASLMCLVESWPKPSPSNIKWYFETSELAIISTERRYLINKRQLMGVE-SKLFFKKVIDSDYGTYTCSF-----SYGKTIVTKQIHLLPLKNKFIIFISIGALGVLVLLIIAVAIICACKKGTSKKRKCKKTPLQKI 625

The following BLAST results are available for this feature:

BLAST of NEPH-2 vs. Ensembl Human
BLAST of NEPH-2 vs. Ensembl Celegans
BLAST of NEPH-2 vs. Ensembl Fly
BLAST of NEPH-2 vs. Ensembl Zebrafish
BLAST of NEPH-2 vs. Ensembl Xenopus
BLAST of NEPH-2 vs. Ensembl Mouse
BLAST of NEPH-2 vs. UniProt/SwissProt
BLAST of NEPH-2 vs. TrEMBL
BLAST of NEPH-2 vs. Ensembl Cavefish
BLAST of NEPH-2 vs. Ensembl Sea Lamprey
BLAST of NEPH-2 vs. Ensembl Yeast
BLAST of NEPH-2 vs. Ensembl Nematostella
BLAST of NEPH-2 vs. Ensembl Medaka
BLAST of NEPH-2 vs. Planmine SMEST

BLAST of NEPH-2 vs. Ensembl Human
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Human e!99)
Total hits: 5


Match Name	E-value	Identity	Description
KIRREL3	1.759e-40	25.86	kirre like nephrin family adhesion molecule 3 [Sou...	[more]
KIRREL1	1.447e-38	23.68	kirre like nephrin family adhesion molecule 1 [Sou...	[more]
KIRREL3	4.487e-38	25.28	kirre like nephrin family adhesion molecule 3 [Sou...	[more]
KIRREL3	7.649e-38	25.28	kirre like nephrin family adhesion molecule 3 [Sou...	[more]
KIRREL1	3.170e-28	23.46	kirre like nephrin family adhesion molecule 1 [Sou...	[more]

BLAST of NEPH-2 vs. Ensembl Celegans
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99)
Total hits: 5


Match Name	E-value	Identity	Description
syg-1	1.736e-34	25.86	Synaptogenesis protein syg-1 [Source:UniProtKB/Sw...	[more]
syg-1	2.154e-34	25.86	Synaptogenesis protein syg-1 [Source:UniProtKB/Sw...	[more]
him-4	5.935e-14	20.87	High Incidence of Males (Increased X chromosome lo...	[more]
him-4	2.804e-13	21.21	High Incidence of Males (Increased X chromosome lo...	[more]
him-4	3.377e-13	21.21	High Incidence of Males (Increased X chromosome lo...	[more]

BLAST of NEPH-2 vs. Ensembl Fly
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99)
Total hits: 5


Match Name	E-value	Identity	Description
kirre	2.761e-44	26.90	gene:FBgn0028369 transcript:FBtr0332492	[more]
kirre	2.761e-44	26.90	gene:FBgn0028369 transcript:FBtr0309498	[more]
kirre	2.761e-44	26.90	gene:FBgn0028369 transcript:FBtr0070560	[more]
kirre	2.761e-44	26.90	gene:FBgn0028369 transcript:FBtr0309499	[more]
kirre	2.761e-44	26.90	gene:FBgn0028369 transcript:FBtr0070559	[more]

BLAST of NEPH-2 vs. Ensembl Zebrafish
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99)
Total hits: 5


Match Name	E-value	Identity	Description
kirrel3a	8.576e-42	25.62	kirre like nephrin family adhesion molecule 3a [So...	[more]
kirrel3a	3.269e-41	25.62	kirre like nephrin family adhesion molecule 3a [So...	[more]
kirrel3a	3.269e-41	25.62	kirre like nephrin family adhesion molecule 3a [So...	[more]
KIRREL3	2.992e-39	24.80	kirre like nephrin family adhesion molecule 3 [Sou...	[more]
kirrel1a	2.252e-38	25.19	kirre like nephrin family adhesion molecule 1a [So...	[more]

BLAST of NEPH-2 vs. Ensembl Xenopus
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99)
Total hits: 5


Match Name	E-value	Identity	Description
eif4e	1.839e-40	24.01	eukaryotic translation initiation factor 4E [Sourc...	[more]
eif4e	2.153e-40	24.02	eukaryotic translation initiation factor 4E [Sourc...	[more]
eif4e	3.503e-40	24.02	eukaryotic translation initiation factor 4E [Sourc...	[more]
rps7	6.649e-40	25.29	ribosomal protein S7 [Source:Xenbase;Acc:XB-GENE-9...	[more]
rps7	9.567e-40	25.29	ribosomal protein S7 [Source:Xenbase;Acc:XB-GENE-9...	[more]

BLAST of NEPH-2 vs. Ensembl Mouse
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99)
Total hits: 5


Match Name	E-value	Identity	Description
Kirrel3	2.643e-41	25.86	kirre like nephrin family adhesion molecule 3 [Sou...	[more]
Kirrel3	1.172e-40	25.86	kirre like nephrin family adhesion molecule 3 [Sou...	[more]
Kirrel3	1.172e-40	25.86	kirre like nephrin family adhesion molecule 3 [Sou...	[more]
Kirrel3	1.230e-40	25.86	kirre like nephrin family adhesion molecule 3 [Sou...	[more]
Kirrel	1.365e-38	23.88	kirre like nephrin family adhesion molecule 1 [Sou...	[more]

BLAST of NEPH-2 vs. UniProt/SwissProt
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt)
Total hits: 5


Match Name	E-value	Identity	Description
sp\|Q08180\|ICCR_DROME	1.284e-41	25.41	Irregular chiasm C-roughest protein OS=Drosophila ...	[more]
sp\|Q96J84\|KIRR1_HUMAN	6.950e-38	23.68	Kin of IRRE-like protein 1 OS=Homo sapiens OX=9606...	[more]
sp\|Q80W68\|KIRR1_MOUSE	9.548e-38	23.88	Kin of IRRE-like protein 1 OS=Mus musculus OX=1009...	[more]
sp\|Q6X936\|KIRR1_RAT	1.290e-37	23.88	Kin of IRRE-like protein 1 OS=Rattus norvegicus OX...	[more]
sp\|Q8IZU9\|KIRR3_HUMAN	3.673e-37	25.28	Kin of IRRE-like protein 3 OS=Homo sapiens OX=9606...	[more]

BLAST of NEPH-2 vs. TrEMBL
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL)
Total hits: 5


Match Name	E-value	Identity	Description
A0A0H3YFE9	0.000e+0	100.00	NEPH-2 OS=Schmidtea mediterranea OX=79327 GN=NEPH-...	[more]
A0A4E0S4A9	3.634e-145	38.04	Irregular chiasm C-roughest protein OS=Fasciola he...	[more]
A0A4S2MJS2	1.415e-135	35.70	Uncharacterized protein OS=Opisthorchis felineus O...	[more]
A0A4S2MJ83	3.432e-135	35.70	Uncharacterized protein OS=Opisthorchis felineus O...	[more]
A0A0H3YJJ7	8.199e-135	33.79	NEPH-3 (Fragment) OS=Schmidtea mediterranea OX=793...	[more]

BLAST of NEPH-2 vs. Ensembl Cavefish
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99)
Total hits: 5


Match Name	E-value	Identity	Description
KIRREL3	9.531e-42	25.43	kirre like nephrin family adhesion molecule 3 [Sou...	[more]
KIRREL3	1.245e-41	25.43	kirre like nephrin family adhesion molecule 3 [Sou...	[more]
kirrel3a	3.234e-39	25.62	kirre like nephrin family adhesion molecule 3a [So...	[more]
kirrel1a	2.360e-36	24.62	kirre like nephrin family adhesion molecule 1 [Sou...	[more]
kirrel1b	1.441e-31	23.85	kirre like nephrin family adhesion molecule 1b [So...	[more]

BLAST of NEPH-2 vs. Ensembl Sea Lamprey
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99)
Total hits: 5


Match Name	E-value	Identity	Description
ENSPMAT00000010550.1	4.856e-18	27.72	pep scaffold:Pmarinus_7.0:GL479154:26986:35474:-1 ...	[more]
ENSPMAT00000010567.1	1.449e-12	22.08	pep scaffold:Pmarinus_7.0:GL479154:561817:685780:1...	[more]
pxdn	2.151e-10	22.85	peroxidasin [Source:ZFIN;Acc:ZDB-GENE-140415-2]	[more]
cntn3b	7.686e-10	24.13	contactin 3b [Source:ZFIN;Acc:ZDB-GENE-130530-645]	[more]
ENSPMAT00000004946.1	1.909e-8	21.89	pep scaffold:Pmarinus_7.0:GL501092:7822:21335:1 ge...	[more]

BLAST of NEPH-2 vs. Ensembl Yeast
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46)
Total hits: 0


Match Name	E-value	Identity	Description

BLAST of NEPH-2 vs. Ensembl Nematostella
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46)
Total hits: 5


Match Name	E-value	Identity	Description
EDO45383	1.008e-8	27.71	Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7...	[more]
EDO30451	1.418e-8	23.75	Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7...	[more]
EDO29616	1.503e-8	22.85	Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7...	[more]
EDO31942	7.634e-8	22.22	Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7...	[more]
EDO27477	1.908e-7	22.09	Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7...	[more]

BLAST of NEPH-2 vs. Ensembl Medaka
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99)
Total hits: 5


Match Name	E-value	Identity	Description
KIRREL3	2.052e-41	25.48	kirre like nephrin family adhesion molecule 3 [Sou...	[more]
KIRREL3	4.539e-41	25.48	kirre like nephrin family adhesion molecule 3 [Sou...	[more]
KIRREL3	6.677e-41	25.10	kirre like nephrin family adhesion molecule 3 [Sou...	[more]
KIRREL3	1.173e-39	25.29	kirre like nephrin family adhesion molecule 3 [Sou...	[more]
kirrel1a	9.116e-35	23.87	kin of IRRE-like protein 1 [Source:NCBI gene;Acc:1...	[more]

BLAST of NEPH-2 vs. Planmine SMEST
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST)
Total hits: 5


Match Name	E-value	Identity	Description
SMESG000071657.1	0.000e+0	100.00	SMESG000071657.1	[more]
SMESG000022777.1	4.489e-138	33.66	SMESG000022777.1	[more]
SMESG000022777.1	6.973e-138	33.66	SMESG000022777.1	[more]
SMESG000074081.1	1.053e-40	25.97	SMESG000074081.1	[more]
SMESG000077979.1	5.441e-24	21.54	SMESG000077979.1	[more]

Analyses

This transcript is derived from or has results from the following analyses


Analysis Name	Date Performed
Embryonic Stages	2016-07-25
Schmidtea mediterranea smed_20140614 BLASTX Human e!99	2016-08-08
Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99	2016-08-08
Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL	2020-05-01
Schmidtea mediterranea Sexual smed_20140614 transcriptome	2016-07-25
Schmidtea mediteranean smed_20140614 Interproscan	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST	2020-05-08

Cross References

External references for this transcript


Database	Accession
SmedGD GBrowse	SMED30012867
GenBank	AKN21715.1

Sequences

The following sequences are available for this feature:

transcript sequence
protein sequence

transcript sequence

>SMED30012867 ID=SMED30012867|Name=NEPH-2|organism=Schmidtea mediterranea sexual|type=transcript|length=3052bp
TAGAAGTGTTCTAGAATTTAATTGGCTGGTTTTTGAATCATCTCTCATGA
TGCATTTGCTGATGCCGTTTTTCCATTCGGTGTGCTAGATGCTGCATGCT
ATCTCAACTTTCAAAAACTGGTGCTGCGCTATTTTCAAAACAGAATTAGC
CGTTTTTTTTGTTGTTGTGAAAATTTATTATTTAATTTGATCTTCTCAAG
AACCTTCGGAAAATTTTTCGGTGAAATAGATTTTGATTGGAAAAGAGATC
TTTCAGGAAAAAAAAACTAATAAACATTTGAGTTTTTTTTTCAGATTAGA
TTATTATTATTATTGTTATTTATTATTTTATTTTTCGAAAAACGGGAGTA
TATATCAGTTCTATTATTTATTGAAAAAAAGAAATGCTATTGAAACTTTT
CATATTCATTATTAGTTTGAAATTTATTTTTGGAAATGAAAATTACATAA
ATGTTCATCCTGAAAATCAAAGAGTCACTTTGAACAGCACTGTGACTATT
CAGTGCAGAGTTCAGCCAATAAAAAATATGAAAGTTTATTGGGTTAAAAG
TGGCTTTGGATTAGGAGAAACTCGTTCTGATATCAGATCTTTTGGAATGG
TTGGCAACAAGGTTCGATATGACATACCAAACGATCTTTCAGCTGGAAAT
TACGATCTGCAGATTACAGATGTAAACTTGGAGGATGAAGGAGATTTCTA
CTGCCAAATGAATATAAAAAACAATGCCATAACTAGTCAACGAGCTCAAC
TGCATGTTTTAGTTGCTTCAGGGCCACCGAAAATTATTCAAATAGGCAAT
CAAGGAATGGGGCCTGAAAAACTGCGAAATGAAAACTCTCCAATTGTCGT
AGACAATGGAGACCTAATGGCACTTAGGTGTCAGGCAGAAAGAGGCCGAC
CAGGAGCTCGGTTGACGTGGATGATTGACAATGAAATTATCGAACCGGAT
TTAAGTGGGAATTTTAATGGAATTATAAGTGGAACTATTACTAATATTTC
GAAGAAAATCGTAAATAATACGAAATTGCGAGACTCATTCAGCACATTAA
AAGCCAAAGTTAATCAGCTTTTGAATGGGAAATCAATAAAATGTTCTGCG
ACCAACAGAGGATTCGAAAAGTTTAATTTTCCAGAGGCGAAAGCAAAAAT
TGAAATACATGTGGCACCTACAGTGACAATGGATATTGTATCCCAGAATT
TAGGAAATGAGTTCTCAGAAAATGATTGGATCACCATTTCCTGCTCCGCT
CTGGGCAGACCAGACAAATTTCTCTGGAAGTGGTATATAAATGACAATGA
GGTAATGAATGATAACCGAAGCTCCTACAAGATCAAAGCTACTCGAACAA
TGAATAAAGCTGTTGTGAAATGCATTGCTAATAATGGAAAAGAAGGTCAT
GATCTGAGGATGCTTAACGTTAAATATGGACCCCAGTTCAAAGATGATTC
TCCACCTCTTTATCCAGCTAATATTGGTGATGATGTAACGTTAACTTGCA
ATACTGACAGCAATCCAATGGCAAATATTTACTGGCAAAGAGAATCCAAT
AATGACATCATTGGTCATGGAACCATTTTATACAGAAAGAACATCCAAGA
ACTTGATTTCGGTACATACATTTGTACGGCTGGTGTGGAAAACTTTGATT
TGAAATCAAAAAAAATAATTCTAGCAAAACGAATCAAGCCGATGATCCGT
GAAAATCCTGATCACAGAGCCTCACTAGGAAGATCAGTTCAAGCGAAATG
TGTCATAGATTCAATTCCAATAGCAAATCACAATCAAATAATGTGGCTCT
ACCGGGGTCGGCGTTTGATAAACGACAACACTAAATACAGTATTTCCACA
GAAAAATATGTCGATCATTCAATAAGTATCTTAAGCATCAATAACATCCA
AGCAAGTGATTTCGGTCAGTATAACTGCTCGGTAACTACCGATTTGGGGT
CAGCTTCAAAGGTCATGGTGTTATCTAAAACAAGTCCAATTCCTTTAATA
CTTATCGTCGGTGGCACTGTTTTCATAACCATGGTGATGATGATTGTCAT
AATTGCTCTATGTGTCTGTAAAAGAGGAATATGCAGCAACAAATATCAGA
AAGGAAGTCCAACAAATCGTATCAATAGCAATAATTCTACAGATCCATTG
AAAAGTCCCCAGTTTGAAATGGACTACCAGTGCCAACCGAATTTCTTTCA
ATGGATTCCTAATAATAATAGAGAACAAGTAAAATCATCTTTCGTCAGAT
ATGGACAGGATGTAGACGACAGGAGTTCTATTCGAAATGGAAGTATCAAT
CAGTATCGTGGATTGGATATGTGCTCGACATATACAAGTTCAATTCCCGG
AAGTCAAAACGGAGAAAAGCCAATCAGAAATCCTGATATTGATGATGTTT
ACAAAGAAGAATTTTATCCATCTTCTAATCCTGCAATGATGTGCAGCATG
CACATTACTCCGACAGGAAGTGGAGCAATTAACCGAGCATCCCCATGCAA
TGCACATCCTTATTCAGTTCCCCAACATCAAATATCTTTACCACAATACA
ATTTTACATCTTTTGCTAACCCGCCATACCTTTCAAATTATCTACCCGGT
TCTAATAACAATTTTGCACTGCCATCATACCCAGTTCACTCACCATCATC
GGAGCCCGGTATAAATGGTGGGTCTGGATTAATGATACCCCCCGTTTTAC
CCCCAATCGACACAAATGATGCAAATCACAATGTCGAACTAGGTCTTTCT
CCCCAGCAAACTTCTTTCATCAAACCCGGCATGACAATAAGCCAAAACAT
GGCTAATTATTTATCACCAAATATTCGTCCAAAACCAAATTCATATAATT
ATACATTATCTGGTAACAGTAATGATGGAAACAGTTTCAAGAGTCGGACT
CTTGATCGTCGAGGACCAATATCTAGTTTTACCAATGTTGATCAAACAAC
AAATATTTAATACTCATTTGTGATTATTATTGTCATCAATATTACTTTGT
ACAAAAATATTTTATTTCCAAAAAATAAAGCGTCTGTTTTTTTATATCAT
TA

protein sequence of SMED30012867-orf-1

>SMED30012867-orf-1 ID=SMED30012867-orf-1|Name=SMED30012867-orf-1|organism=Schmidtea mediterranea sexual|type=polypeptide|length=859bp
MLLKLFIFIISLKFIFGNENYINVHPENQRVTLNSTVTIQCRVQPIKNMK
VYWVKSGFGLGETRSDIRSFGMVGNKVRYDIPNDLSAGNYDLQITDVNLE
DEGDFYCQMNIKNNAITSQRAQLHVLVASGPPKIIQIGNQGMGPEKLRNE
NSPIVVDNGDLMALRCQAERGRPGARLTWMIDNEIIEPDLSGNFNGIISG
TITNISKKIVNNTKLRDSFSTLKAKVNQLLNGKSIKCSATNRGFEKFNFP
EAKAKIEIHVAPTVTMDIVSQNLGNEFSENDWITISCSALGRPDKFLWKW
YINDNEVMNDNRSSYKIKATRTMNKAVVKCIANNGKEGHDLRMLNVKYGP
QFKDDSPPLYPANIGDDVTLTCNTDSNPMANIYWQRESNNDIIGHGTILY
RKNIQELDFGTYICTAGVENFDLKSKKIILAKRIKPMIRENPDHRASLGR
SVQAKCVIDSIPIANHNQIMWLYRGRRLINDNTKYSISTEKYVDHSISIL
SINNIQASDFGQYNCSVTTDLGSASKVMVLSKTSPIPLILIVGGTVFITM
VMMIVIIALCVCKRGICSNKYQKGSPTNRINSNNSTDPLKSPQFEMDYQC
QPNFFQWIPNNNREQVKSSFVRYGQDVDDRSSIRNGSINQYRGLDMCSTY
TSSIPGSQNGEKPIRNPDIDDVYKEEFYPSSNPAMMCSMHITPTGSGAIN
RASPCNAHPYSVPQHQISLPQYNFTSFANPPYLSNYLPGSNNNFALPSYP
VHSPSSEPGINGGSGLMIPPVLPPIDTNDANHNVELGLSPQQTSFIKPGM
TISQNMANYLSPNIRPKPNSYNYTLSGNSNDGNSFKSRTLDRRGPISSFT
NVDQTTNI*

Annotated Terms

The following terms have been associated with this transcript:

Vocabulary: **Planarian Anatomy**
Term	Definition
PLANA:0000099	neuron
PLANA:0000101	muscle cell
PLANA:0000140	anterior region of the whole animal
PLANA:0002032	epidermal cell

Vocabulary: **INTERPRO**
Term	Definition
IPR036179	Ig-like_dom_sf
IPR013106	Ig_V-set
IPR003599	Ig_sub
IPR003598	Ig_sub2
IPR013783	Ig-like_fold
IPR013098	Ig_I-set
IPR013162	CD80_C2-set
IPR007110	Ig-like_dom

Vocabulary: **molecular function**
Term	Definition
GO:0005515	protein binding

Vocabulary: **cellular component**
Term	Definition
GO:0016020	membrane
GO:0016021	integral component of membrane

InterPro

Analysis Name: Schmidtea mediteranean smed_20140614 Interproscan
Date Performed: 2020-05-01


IPR Term	IPR Description	Source	Source Term	Source Description	Alignment
IPR003599	Immunoglobulin subtype	SMART	SM00409	IG_3c	coord: 26..126 e-value: 4.5E-11 score: 52.8 coord: 151..347 e-value: 140.0 score: 1.4 coord: 357..433 e-value: 0.0017 score: 27.6 coord: 441..530 e-value: 3.4E-5 score: 33.3
IPR003598	Immunoglobulin subtype 2	SMART	SM00408	igc2_5	coord: 32..114 e-value: 0.87 score: 7.7 coord: 447..522 e-value: 0.13 score: 15.8 coord: 363..421 e-value: 0.0017 score: 27.6
IPR013106	Immunoglobulin V-set domain	SMART	SM00406	igv1_8	coord: 367..517 e-value: 2.3 score: 1.0 coord: 36..109 e-value: 0.0021 score: 27.3
IPR013106	Immunoglobulin V-set domain	PFAM	PF07686	V-set	coord: 26..126 e-value: 1.3E-9 score: 38.2
IPR013098	Immunoglobulin I-set	PFAM	PF07679	I-set	coord: 443..530 e-value: 2.1E-7 score: 30.9
IPR013783	Immunoglobulin-like fold	GENE3D	G3DSA:2.60.40.10		coord: 433..532 e-value: 6.1E-15 score: 57.2
IPR013783	Immunoglobulin-like fold	GENE3D	G3DSA:2.60.40.10		coord: 17..130 e-value: 5.8E-21 score: 76.5
IPR013783	Immunoglobulin-like fold	GENE3D	G3DSA:2.60.40.10		coord: 265..346 e-value: 3.6E-5 score: 25.7
IPR013783	Immunoglobulin-like fold	GENE3D	G3DSA:2.60.40.10		coord: 347..429 e-value: 3.9E-11 score: 45.0
IPR013783	Immunoglobulin-like fold	GENE3D	G3DSA:2.60.40.10		coord: 147..264 e-value: 5.8E-10 score: 41.3
IPR013162	CD80-like, immunoglobulin C2-set	PFAM	PF08205	C2-set_2	coord: 163..245 e-value: 1.2E-4 score: 22.1
None	No IPR available	PFAM	PF13927	Ig_3	coord: 362..416 e-value: 4.7E-8 score: 33.5
None	No IPR available	PANTHER	PTHR11640	NEPHRIN	coord: 18..576
None	No IPR available	PANTHER	PTHR11640:SF31	NEPHROSIS 1, CONGENITAL, FINNISH TYPE (NEPHRIN)-RELATED	coord: 18..576
None	No IPR available	CDD	cd00096	Ig	coord: 368..416 e-value: 1.99739E-5 score: 41.0737
None	No IPR available	CDD	cd00096	Ig	coord: 37..108 e-value: 7.5207E-5 score: 39.5329
None	No IPR available	SIGNALP_EUK	SignalP-noTM	SignalP-noTM	coord: 1..17 score: 0.814
None	No IPR available	TMHMM	TMhelix		coord: 539..561
IPR007110	Immunoglobulin-like domain	PROSITE	PS50835	IG_LIKE	coord: 20..124 score: 9.029
IPR007110	Immunoglobulin-like domain	PROSITE	PS50835	IG_LIKE	coord: 350..416 score: 10.335
IPR007110	Immunoglobulin-like domain	PROSITE	PS50835	IG_LIKE	coord: 262..347 score: 8.266
IPR007110	Immunoglobulin-like domain	PROSITE	PS50835	IG_LIKE	coord: 436..531 score: 11.116
IPR007110	Immunoglobulin-like domain	PROSITE	PS50835	IG_LIKE	coord: 132..257 score: 7.758
IPR036179	Immunoglobulin-like domain superfamily	SUPERFAMILY	SSF48726	Immunoglobulin	coord: 345..416
IPR036179	Immunoglobulin-like domain superfamily	SUPERFAMILY	SSF48726	Immunoglobulin	coord: 258..335
IPR036179	Immunoglobulin-like domain superfamily	SUPERFAMILY	SSF48726	Immunoglobulin	coord: 435..531
IPR036179	Immunoglobulin-like domain superfamily	SUPERFAMILY	SSF48726	Immunoglobulin	coord: 22..132

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NEPH-2

Zeng et. al., 2018

▻ Overview

▻ Neoblast Population

▻ Sub-lethal Irradiated Surviving X1 and X2 Cell Population

Overview

Single cell RNA-seq of pluripotent neoblasts and its early progenies

Explore this single cell expression dataset with our NB Cluster Shiny App

Neoblast Population

Sub-lethal Irradiated Surviving X1 and X2 Cell Population

Davies et. al., 2017

PAGE et. al., 2020

has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGE

PAGE Curations: 5

Owlery

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