Methionine synthase
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Overview
Neoblast Clusters
Zeng et. al., 2018▻ Overview▻ Neoblast Population▻ Sub-lethal Irradiated Surviving X1 and X2 Cell Population
Overview
Single cell RNA-seq of pluripotent neoblasts and its early progeniesWe isolated X1 neoblasts cells enriched in high piwi-1 expression (Neoblast Population), and profiled ∼7,614 individual cells via scRNA-seq. Unsupervised analyses uncovered 12 distinct classes from 7,088 high-quality cells. We designated these classes Nb1 to Nb12 and ordered them based on high (Nb1) to low (Nb12) piwi-1 expression levels. We further defined groups of genes that best classified the cells parsed into 12 distinct cell clusters to generate a scaled expression heat map of discriminative gene sets for each cluster. Expression of each cluster’s gene signatures was validated using multiplex fluorescence in situ hybridization (FISH) co-stained with piwi-1 and largely confirmed the cell clusters revealed by scRNA-seq.We also tested sub-lethal irradiation exposure. To profile rare pluripotent stem cells (PSCs) and avoid interference from immediate progenitor cells, we determined a time point after sub-lethal irradiation (7 DPI) with minimal piwi-1+ cells, followed by isolation and single-cell RNA-seq of 1,200 individual cells derived from X1 (Piwi-1 high) and X2 (Piwi-1 low) cell populations (Sub-lethal Irradiated Surviving X1 and X2 Cell Population)Explore this single cell expression dataset with our NB Cluster Shiny App
Neoblast Population
Sub-lethal Irradiated Surviving X1 and X2 Cell Population
Embryonic Expression
Davies et. al., 2017
Hover the mouse over a column in the graph to view average RPKM values per sample. Embryonic Stages: Y: yolk. S2-S8: Stages 2-8. C4: asexual adult. SX: virgin, sexually mature adult. back to top Anatomical Expression
PAGE et. al., 2020SMED30012817 has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGEPAGE Curations: 6
Homology
BLAST of Methionine synthase vs. Ensembl Human
Match: MTR (5-methyltetrahydrofolate-homocysteine methyltransferase [Source:HGNC Symbol;Acc:HGNC:7468]) HSP 1 Score: 1596.64 bits (4133), Expect = 0.000e+0 Identity = 800/1259 (63.54%), Postives = 987/1259 (78.40%), Query Frame = 3
Query: 27 MRKNIKSVLFSTLRERIMILDGAMGTMIQTYKLEENDFRGEIFKDHPKLLRGNNDLLSLTKPDIVFNIHKEFLDSGADIIETNTFSGTAIAQADYGLEHMVYKLNYESAILARKACDLVSSKSGISRFVAGAIGPTNRTLSISPSVEKPEYRNITFDQLVTAYKEQAHALLDGGVDILLIETIFDTANAKAAVFALFEVFEEAGYEVPVFISGTIVDKSGRNLSGQTTEAFLTSISHIKPICIGLNCALGASDMRPFIETISANTTSFVICYPNAGLPNTFGAYDEKPEYTGEILSQFAKDGLINIVGGCCGTTPAHIAAIKKAVRGYSPRIPPTTLFEDCLVLSGLERFIINPRTTLFVNIGERCNVAGSRRFLRLIKTDKYEEALSIAKEQVENGAQVIDLNMDEGMLEGKLAMTKFINLISSEPDISKVPLCIDSSNFAVIEAGLKCTQGKCIVNSISLKEGELDFYRKLKIIKKFGAAVVIMAFDEQGQAADYDRKIAICCRIYDLLVNKMDFNPNDIIFDLNILTIGTGMEEHNGYGMDFIRATEFVKKNLPHAKVSGGVSNISFSFRGKEVVREAMHSVFLFHAIKAGMDMGIVNAGCLPVYDDIEPRLLELCEDILWNKRQDATDRLLEYAENLLKSDDVGILKTEDAWRSLSVSERLEHSLVKGIDKYIIEDTEEAR---KCHVRPLHVIEGPLMRGMSTVGDLFGAGKMFLPQVIKSARVMKRAVGYLIPFMEEEKRLAMEVSGIYSNEPQYVGTMVIATVKGDVHDIGKNIVGVVMGCNNYRVIDLGVMCPSEKILQCALEEKADVIGLSGLITPSLEEMMHVAREMERLGMRTPLLIGGATTSRQHTAVKIAPKYSGPTVHVLDASKSVVVTNSLLDDTXXXXXXXXXXXXXXXXXXXXXXSLAERIYLSIDEARKRKLQLNWSIDHFQSHRPNFLGSKIVENIDINILLPYIDWKPFFDVWQLRGKYPNRGYPKIFNDKDVGKEAQILFSDAQKVLFEIIQYKLLHVNGVIGFYPAHSEGDDILLYDPDSFNVNRKNHLTTLFGLRQQEEREDPN---YLCISDFIAPIESGCDDYVGMFAVTAGIGADSLAQKFQDQGDDYNSLMVKALADRLAEASAEYLHHIVRTTLWGYSPNENLTPEDYIKVMYDGIRPAPGYPTQPDHSEQATVWDLLKPER-IGINLHKDSLGMSPAASVSGLYFSHPKSKYFSVGKISKDQVYDYAKRKQISIGESEKRLQSILSYETD 3782
++K ++ + + L++RIM+LDG MGTMIQ KL E FRG+ FKDH + L+GNND+LS+T+PD+++ IHKE+L +GADIIETNTFS T+IAQADYGLEH+ Y++N SA +ARKA + V+ ++GI RFVAGA+GPTN+TLS+SPSVE+P+YRNITFD+LV AY+EQA LLDGGVDILLIETIFDTANAKAA+FAL +FEE P+FISGTIVDKSGR LSGQT E F+ S+SH +P+CIGLNCALGA++MRPFIE I TT++V+CYPNAGLPNTFG YDE P + L FA DGL+NIVGGCCG+TP HI I +AV+ PR+PP T FE ++LSGLE F I P T FVNIGERCNVAGSR+F +LI YEEAL +AK QVE GAQV+D+NMD+GML+G AMT+F NLI+SEPDI+KVPLCIDSSNFAVIEAGLKC QGKCIVNSISLKEGE DF K + IKK+GAA+V+MAFDE+GQA + D KI +C R Y LLV K+ FNPNDIIFD NILTIGTGMEEHN Y ++FI AT+ +K+ LP A++SGG+SN+SFSFRG E +REAMH VFL+HAIK+GMDMGIVNAG LPVYDDI LL+LCED++WNK +AT++LL YA+ + +++T D WR+ V ERLE++LVKGI+K+IIEDTEEAR K + RPL++IEGPLM GM VGDLFGAGKMFLPQVIKSARVMK+AVG+LIPFME+E+ ++G E Y GT+V+ATVKGDVHDIGKNIVGVV+GCNN+RVIDLGVM P +KIL+ AL+ KAD+IGLSGLITPSL+EM+ VA+EMERL +R PLLIGGATTS+ HTAVKIAP+YS P +HVLDASKSVVV + LLD+ E+ E I EEYE+IR++HYESL ER YL + +ARK Q++W + +P F+G+++ E+ D+ L+ YIDWKPFFDVWQLRGKYPNRG+PKIFNDK VG EA+ ++ DA +L +I K L GV+GF+PA S DDI LY ++ + T +GLRQQ E++ + Y C+SDFIAP+ SG DY+G+FAV A G + L++ ++D GDDY+S+MVKAL DRLAEA AE LH VR LW Y +E L D ++ Y GIRPAPGYP+QPDH+E+ T+W L E+ GI L +SL M+PA++VSGLYFS+ KSKYF+VGKISKDQV DYA RK IS+ E EK L IL Y+TD
Sbjct: 14 LKKTLRDEINAILQKRIMVLDGGMGTMIQREKLNEEHFRGQEFKDHARPLKGNNDILSITQPDVIYQIHKEYLLAGADIIETNTFSSTSIAQADYGLEHLAYRMNMCSAGVARKAAEEVTLQTGIKRFVAGALGPTNKTLSVSPSVERPDYRNITFDELVEAYQEQAKGLLDGGVDILLIETIFDTANAKAALFALQNLFEEKYAPRPIFISGTIVDKSGRTLSGQTGEGFVISVSHGEPLCIGLNCALGAAEMRPFIEIIGKCTTAYVLCYPNAGLPNTFGDYDETPSMMAKHLKDFAMDGLVNIVGGCCGSTPDHIREIAEAVKNCKPRVPPATAFEGHMLLSGLEPFRIGPYTN-FVNIGERCNVAGSRKFAKLIMAGNYEEALCVAKVQVEMGAQVLDVNMDDGMLDGPSAMTRFCNLIASEPDIAKVPLCIDSSNFAVIEAGLKCCQGKCIVNSISLKEGEDDFLEKARKIKKYGAAMVVMAFDEEGQATETDTKIRVCTRAYHLLVKKLGFNPNDIIFDPNILTIGTGMEEHNLYAINFIHATKVIKETLPGARISGGLSNLSFSFRGMEAIREAMHGVFLYHAIKSGMDMGIVNAGNLPVYDDIHKELLQLCEDLIWNKDPEATEKLLRYAQT-QGTGGKKVIQT-DEWRNGPVEERLEYALVKGIEKHIIEDTEEARLNQKKYPRPLNIIEGPLMNGMKIVGDLFGAGKMFLPQVIKSARVMKKAVGHLIPFMEKEREETRVLNGTVEEEDPYQGTIVLATVKGDVHDIGKNIVGVVLGCNNFRVIDLGVMTPCDKILKAALDHKADIIGLSGLITPSLDEMIFVAKEMERLAIRIPLLIGGATTSKTHTAVKIAPRYSAPVIHVLDASKSVVVCSQLLDENLKDEYFEEIMEEYEDIRQDHYESLKERRYLPLSQARKSGFQMDW-LSEPHPVKPTFIGTQVFEDYDLQKLVDYIDWKPFFDVWQLRGKYPNRGFPKIFNDKTVGGEARKVYDDAHNMLNTLISQKKLRARGVVGFWPAQSIQDDIHLY-AEAAVPQAAEPIATFYGLRQQAEKDSASTEPYYCLSDFIAPLHSGIRDYLGLFAV-ACFGVEELSKAYEDDGDDYSSIMVKALGDRLAEAFAEELHERVRRELWAYCGSEQLDVADLRRLRYKGIRPAPGYPSQPDHTEKLTMWRLADIEQSTGIRL-TESLAMAPASAVSGLYFSNLKSKYFAVGKISKDQVEDYALRKNISVAEVEKWLGPILGYDTD 1265
BLAST of Methionine synthase vs. Ensembl Human
Match: MTR (5-methyltetrahydrofolate-homocysteine methyltransferase [Source:HGNC Symbol;Acc:HGNC:7468]) HSP 1 Score: 1498.8 bits (3879), Expect = 0.000e+0 Identity = 762/1256 (60.67%), Postives = 944/1256 (75.16%), Query Frame = 3
Query: 27 MRKNIKSVLFSTLRERIMILDGAMGTMIQTYKLEENDFRGEIFKDHPKLLRGNNDLLSLTKPDIVFNIHKEFLDSGADIIETNTFSGTAIAQADYGLEHMVYKLNYESAILARKACDLVSSKSGISRFVAGAIGPTNRTLSISPSVEKPEYRNITFDQLVTAYKEQAHALLDGGVDILLIETIFDTANAKAAVFALFEVFEEAGYEVPVFISGTIVDKSGRNLSGQTTEAFLTSISHIKPICIGLNCALGASDMRPFIETISANTTSFVICYPNAGLPNTFGAYDEKPEYTGEILSQFAKDGLINIVGGCCGTTPAHIAAIKKAVRGYSPRIPPTTLFEDCLVLSGLERFIINPRTTLFVNIGERCNVAGSRRFLRLIKTDKYEEALSIAKEQVENGAQVIDLNMDEGMLEGKLAMTKFINLISSEPDISKVPLCIDSSNFAVIEAGLKCTQGKCIVNSISLKEGELDFYRKLKIIKKFGAAVVIMAFDEQGQAADYDRKIAICCRIYDLLVNKMDFNPNDIIFDLNILTIGTGMEEHNGYGMDFIRATEFVKKNLPHAKVSGGVSNISFSFRGKEVVREAMHSVFLFHAIKAGMDMGIVNAGCLPVYDDIEPRLLELCEDILWNKRQDATDRLLEYAENLLKSDDVGILKTEDAWRSLSVSERLEHSLVKGIDKYIIEDTEEARKCHVRPLHVIEGPLMRGMSTVGDLFGAGKMFLPQVIKSARVMKRAVGYLIPFMEEEKRLAMEVSGIYSNEPQYVGTMVIATVKGDVHDIGKNIVGVVMGCNNYRVIDLGVMCPSEKILQCALEEKADVIGLSGLITPSLEEMMHVAREMERLGMRTPLLIGGATTSRQHTAVKIAPKYSGPTVHVLDASKSVVVTNSLLDDTXXXXXXXXXXXXXXXXXXXXXXSLAERIYLSIDEARKRKLQLNWSIDHFQSHRPNFLGSKIVENIDINILLPYIDWKPFFDVWQLRGKYPNRGYPKIFNDKDVGKEAQILFSDAQKVLFEIIQYKLLHVNGVIGFYPAHSEGDDILLYDPDSFNVNRKNHLTTLFGLRQQEEREDPN---YLCISDFIAPIESGCDDYVGMFAVTAGIGADSLAQKFQDQGDDYNSLMVKALADRLAEASAEYLHHIVRTTLWGYSPNENLTPEDYIKVMYDGIRPAPGYPTQPDHSEQATVWDLLKPER-IGINLHKDSLGMSPAASVSGLYFSHPKSKYFSVGKISKDQVYDYAKRKQISIGESEKRLQSILSYETD 3782
++K ++ + + L++RIM+LDG MGTMIQ KL E FRG+ FKDH + L+GNND+LS+T+PD+++ IHKE+L +GADIIETNTFS T+IAQADYGLEH+ Y++N SA +ARKA + V+ ++GI RFVAGA+GPTN+TLS+SPSVE+P+YRNITFD+LV AY+EQA LLDGGVDILLIETIFDTANAKAA+FAL +FEE P+FISGTIVDKSGR LSGQT E F+ S+SH +P+CIGLNCALGA++MRPFIE I TT++V+CYPNAGLPNTFG YDE P + L FA DGL+NIVGGCCG+TP HI I +AV+ PR+PP T FE ++LSGLE F I P T FVNIGERCNVAGSR+F +LI YEEAL +AK QVE GAQV+D+NMD+GML+G AMT+F NLI+SEPDI+KVPLCIDSSNFAVIEAGLKC QGKCIVNSISLKEGE DF K + IKK+GAA+V+MAFDE+GQA + D KI +C R Y LLV K+ FNPNDIIFD NILTIGTGMEEHN Y ++FI AT+ +K+ LP A++SGG+SN+SFSFRG E +REAMH VFL+HAIK+GMDMGIVNAG LPVYDDI LL+LCED++WNK +AT++LL YA+ + +++T D WR+ V ERLE++LVK VIKSARVMK+AVG+LIPFME+E+ ++G E Y GT+V+ATVKGDVHDIGKNIVGVV+GCNN+RVIDLGVM P +KIL+ AL+ KAD+IGLSGLITPSL+EM+ VA+EMERL +R PLLIGGATTS+ HTAVKIAP+YS P +HVLDASKSVVV + LLD+ E+ E I EEYE+IR++HYESL ER YL + +ARK Q++W + +P F+G+++ E+ D+ L+ YIDWKPFFDVWQLRGKYPNRG+PKIFNDK VG EA+ ++ DA +L +I K L GV+GF+PA S DDI LY ++ + T +GLRQQ E++ + Y C+SDFIAP+ SG DY+G+FAV A G + L++ ++D GDDY+S+MVKAL DRLAEA AE LH VR LW Y +E L D ++ Y GIRPAPGYP+QPDH+E+ T+W L E+ GI L +SL M+PA++VSGLYFS+ KSKYF+VGKISKDQV DYA RK IS+ E EK L IL Y+TD
Sbjct: 14 LKKTLRDEINAILQKRIMVLDGGMGTMIQREKLNEEHFRGQEFKDHARPLKGNNDILSITQPDVIYQIHKEYLLAGADIIETNTFSSTSIAQADYGLEHLAYRMNMCSAGVARKAAEEVTLQTGIKRFVAGALGPTNKTLSVSPSVERPDYRNITFDELVEAYQEQAKGLLDGGVDILLIETIFDTANAKAALFALQNLFEEKYAPRPIFISGTIVDKSGRTLSGQTGEGFVISVSHGEPLCIGLNCALGAAEMRPFIEIIGKCTTAYVLCYPNAGLPNTFGDYDETPSMMAKHLKDFAMDGLVNIVGGCCGSTPDHIREIAEAVKNCKPRVPPATAFEGHMLLSGLEPFRIGPYTN-FVNIGERCNVAGSRKFAKLIMAGNYEEALCVAKVQVEMGAQVLDVNMDDGMLDGPSAMTRFCNLIASEPDIAKVPLCIDSSNFAVIEAGLKCCQGKCIVNSISLKEGEDDFLEKARKIKKYGAAMVVMAFDEEGQATETDTKIRVCTRAYHLLVKKLGFNPNDIIFDPNILTIGTGMEEHNLYAINFIHATKVIKETLPGARISGGLSNLSFSFRGMEAIREAMHGVFLYHAIKSGMDMGIVNAGNLPVYDDIHKELLQLCEDLIWNKDPEATEKLLRYAQT-QGTGGKKVIQT-DEWRNGPVEERLEYALVK------------------------------------------------VIKSARVMKKAVGHLIPFMEKEREETRVLNGTVEEEDPYQGTIVLATVKGDVHDIGKNIVGVVLGCNNFRVIDLGVMTPCDKILKAALDHKADIIGLSGLITPSLDEMIFVAKEMERLAIRIPLLIGGATTSKTHTAVKIAPRYSAPVIHVLDASKSVVVCSQLLDENLKDEYFEEIMEEYEDIRQDHYESLKERRYLPLSQARKSGFQMDW-LSEPHPVKPTFIGTQVFEDYDLQKLVDYIDWKPFFDVWQLRGKYPNRGFPKIFNDKTVGGEARKVYDDAHNMLNTLISQKKLRARGVVGFWPAQSIQDDIHLY-AEAAVPQAAEPIATFYGLRQQAEKDSASTEPYYCLSDFIAPLHSGIRDYLGLFAV-ACFGVEELSKAYEDDGDDYSSIMVKALGDRLAEAFAEELHERVRRELWAYCGSEQLDVADLRRLRYKGIRPAPGYPSQPDHTEKLTMWRLADIEQSTGIRL-TESLAMAPASAVSGLYFSNLKSKYFAVGKISKDQVEDYALRKNISVAEVEKWLGPILGYDTD 1214
BLAST of Methionine synthase vs. Ensembl Human
Match: MTR (5-methyltetrahydrofolate-homocysteine methyltransferase [Source:HGNC Symbol;Acc:HGNC:7468]) HSP 1 Score: 987.252 bits (2551), Expect = 0.000e+0 Identity = 517/852 (60.68%), Postives = 637/852 (74.77%), Query Frame = 3
Query: 1248 GMLEGKLAMTKFINLISSEPDISKVPLCIDSSNFAVIEAGLKCTQGKCIVNSISLKEGELDFYRKLKIIKKFGAAVVIMAFDEQGQAADYDRKIAICCRIYDLLVNKMDFNPNDIIFDLNILTIGTGMEEHNGYGMDFIRATEFVKKNLPHAKVSGGVSNISFSFRGKEVVREAMHSVFLFHAIKAGMDMGIVNAGCLPVYDDIEPRLLELCEDILWNKRQDATDRLLEYAENLLKSDDVGILKTEDAWRSLSVSERLEHSLVKGIDKYIIEDTEEAR---KCHVRPLHVIEGPLMRGMSTVGDLFGAGKMFLPQVIKSARVMKRAVGYLIPFMEEEKRLAMEVSGIYSNEPQYVGTMVIATVKGDVHDIGKNIVGVVMGCNNYRVIDLGVMCPSEKILQCALEEKADVIGLSGLITPSLEEMMHVAREMERLGMRTPLLIGGATTSRQHTAVKIAPKYSGPTVHVLDASKSVVVTNSLLDDTXXXXXXXXXXXXXXXXXXXXXXSLAERIYLSIDEARKRKLQLNWSIDHFQSHRPNFLGSKIVENIDINILLPYIDWKPFFDVWQLRGKYPNRGYPKIFNDKDVGKEAQILFSDAQKVLFEIIQYKLLHVNGVIGFYPAHSEGDDILLYDPDSFNVNRKNHLTTLFGLRQQEEREDPN---YLCISDFIAPIESGCDDYVGMFAVTAGIGADSLAQKFQDQGDDYNSLMVKALADRLAEASAEYLHHIVRTTLWGYSPNENLTPEDYIKVMYDGIRPAPGYPTQPDHSEQATVWDLLKPER-IGINLHKDSLGMSPAASVSGLYFSHPKSKYFSVGKISKDQVYDYAKRKQISIGESEKRLQSILSYETD 3782
GML+G AMT+F NLI+SEPDI+KVPLCIDSSNFAVIEAGLKC QGKCIVNSISLKEGE A + D KI +C R Y LLV K+ FNPNDIIFD NILTIGTGMEEHN Y ++FI AT+ +K+ LP A++SGG+SN+SFSFRG E +REAMH VFL+HAIK+GMDMGIVNAG LPVYDDI LL+LCED++WNK +AT++LL YA+ + +++T D WR+ V ERLE++LVKGI+K+IIEDTEEAR K + RPL++IEGPLM GM VGDLFGAGKMFLPQVIKSARVMK+AVG+LIPFME+E+ ++G E Y GT+V+ATVKGDVHDIGKNIVGVV+GCNN+RVIDLGVM P +KIL+ AL+ KAD+IGLSGLITPSL+EM+ VA+EMERL +R PLLIGGATTS+ HTAVKIAP+YS P +HVLDASKSVVV + LLD+ E+ E I EEYE+IR++HYESL ER YL + +ARK Q++W + +P F+G+++ E+ D+ L+ YIDWKPFFDVWQLRGKYPNRG+PKIFNDK VG EA+ ++ DA +L +I K L GV+GF+PA S DDI LY ++ + T +GLRQQ E++ + Y C+SDFIAP+ SG DY+G+FAV A G + L++ ++D GDDY+S+MVKAL DRLAEA AE LH VR LW Y +E L D ++ Y GIRPAPGYP+QPDH+E+ T+W L E+ GI L +SL M+PA++VSGLYFS+ KSKYF+VGKISKDQV DYA RK IS+ E EK L IL Y+TD
Sbjct: 1 GMLDGPSAMTRFCNLIASEPDIAKVPLCIDSSNFAVIEAGLKCCQGKCIVNSISLKEGE---------------------------ATETDTKIRVCTRAYHLLVKKLGFNPNDIIFDPNILTIGTGMEEHNLYAINFIHATKVIKETLPGARISGGLSNLSFSFRGMEAIREAMHGVFLYHAIKSGMDMGIVNAGNLPVYDDIHKELLQLCEDLIWNKDPEATEKLLRYAQTQ-GTGGKKVIQT-DEWRNGPVEERLEYALVKGIEKHIIEDTEEARLNQKKYPRPLNIIEGPLMNGMKIVGDLFGAGKMFLPQVIKSARVMKKAVGHLIPFMEKEREETRVLNGTVEEEDPYQGTIVLATVKGDVHDIGKNIVGVVLGCNNFRVIDLGVMTPCDKILKAALDHKADIIGLSGLITPSLDEMIFVAKEMERLAIRIPLLIGGATTSKTHTAVKIAPRYSAPVIHVLDASKSVVVCSQLLDENLKDEYFEEIMEEYEDIRQDHYESLKERRYLPLSQARKSGFQMDW-LSEPHPVKPTFIGTQVFEDYDLQKLVDYIDWKPFFDVWQLRGKYPNRGFPKIFNDKTVGGEARKVYDDAHNMLNTLISQKKLRARGVVGFWPAQSIQDDIHLY-AEAAVPQAAEPIATFYGLRQQAEKDSASTEPYYCLSDFIAPLHSGIRDYLGLFAV-ACFGVEELSKAYEDDGDDYSSIMVKALGDRLAEAFAEELHERVRRELWAYCGSEQLDVADLRRLRYKGIRPAPGYPSQPDHTEKLTMWRLADIEQSTGIRL-TESLAMAPASAVSGLYFSNLKSKYFAVGKISKDQVEDYALRKNISVAEVEKWLGPILGYDTD 819
BLAST of Methionine synthase vs. Ensembl Human
Match: MTR (5-methyltetrahydrofolate-homocysteine methyltransferase [Source:HGNC Symbol;Acc:HGNC:7468]) HSP 1 Score: 481.1 bits (1237), Expect = 1.607e-158 Identity = 225/346 (65.03%), Postives = 281/346 (81.21%), Query Frame = 3
Query: 27 MRKNIKSVLFSTLRERIMILDGAMGTMIQTYKLEENDFRGEIFKDHPKLLRGNNDLLSLTKPDIVFNIHKEFLDSGADIIETNTFSGTAIAQADYGLEHMVYKLNYESAILARKACDLVSSKSGISRFVAGAIGPTNRTLSISPSVEKPEYRNITFDQLVTAYKEQAHALLDGGVDILLIETIFDTANAKAAVFALFEVFEEAGYEVPVFISGTIVDKSGRNLSGQTTEAFLTSISHIKPICIGLNCALGASDMRPFIETISANTTSFVICYPNAGLPNTFGAYDEKPEYTGEILSQFAKDGLINIVGGCCGTTPAHIAAIKKAVRGYSPRIPPTTLFEDCLVLSG 1064
++K ++ + + L++RIM+LDG MGTMIQ KL E FRG+ FKDH + L+GNND+LS+T+PD+++ IHKE+L +GADIIETNTFS T+IAQADYGLEH+ Y++N SA +ARKA + V+ ++GI RFVAGA+GPTN+TLS+SPSVE+P+YRNITFD+LV AY+EQA LLDGGVDILLIETIFDTANAKAA+FAL +FEE P+FISGTIVDKSGR LSGQT E F+ S+SH +P+CIGLNCALGA++MRPFIE I TT++V+CYPNAGLPNTFG YDE P + L FA DGL+NIVGGCCG+TP HI I +AV+ PR+PP T FE ++LSG
Sbjct: 14 LKKTLRDEINAILQKRIMVLDGGMGTMIQREKLNEEHFRGQEFKDHARPLKGNNDILSITQPDVIYQIHKEYLLAGADIIETNTFSSTSIAQADYGLEHLAYRMNMCSAGVARKAAEEVTLQTGIKRFVAGALGPTNKTLSVSPSVERPDYRNITFDELVEAYQEQAKGLLDGGVDILLIETIFDTANAKAALFALQNLFEEKYAPRPIFISGTIVDKSGRTLSGQTGEGFVISVSHGEPLCIGLNCALGAAEMRPFIEIIGKCTTAYVLCYPNAGLPNTFGDYDETPSMMAKHLKDFAMDGLVNIVGGCCGSTPDHIREIAEAVKNCKPRVPPATAFEGHMLLSG 359
BLAST of Methionine synthase vs. Ensembl Human
Match: MTR (5-methyltetrahydrofolate-homocysteine methyltransferase [Source:HGNC Symbol;Acc:HGNC:7468]) HSP 1 Score: 340.117 bits (871), Expect = 3.785e-107 Identity = 161/249 (64.66%), Postives = 204/249 (81.93%), Query Frame = 3
Query: 27 MRKNIKSVLFSTLRERIMILDGAMGTMIQTYKLEENDFRGEIFKDHPKLLRGNNDLLSLTKPDIVFNIHKEFLDSGADIIETNTFSGTAIAQADYGLEHMVYKLNYESAILARKACDLVSSKSGISRFVAGAIGPTNRTLSISPSVEKPEYRNITFDQLVTAYKEQAHALLDGGVDILLIETIFDTANAKAAVFALFEVFEEAGYEVPVFISGTIVDKSGRNLSGQTTEAFLTSISHIKPICIGLNCAL 773
++K ++ + + L++RIM+LDG MGTMIQ KL E FRG+ FKDH + L+GNND+LS+T+PD+++ IHKE+L +GADIIETNTFS T+IAQADYGLEH+ Y++N SA +ARKA + V+ ++GI RFVAGA+GPTN+TLS+SPSVE+P+YRNITFD+LV AY+EQA LLDGGVDILLIETIFDTANAKAA+FAL +FEE P+FISGTIVDKSGR LSGQT E F+ S+SH +P+ I L A
Sbjct: 14 LKKTLRDEINAILQKRIMVLDGGMGTMIQREKLNEEHFRGQEFKDHARPLKGNNDILSITQPDVIYQIHKEYLLAGADIIETNTFSSTSIAQADYGLEHLAYRMNMCSAGVARKAAEEVTLQTGIKRFVAGALGPTNKTLSVSPSVERPDYRNITFDELVEAYQEQAKGLLDGGVDILLIETIFDTANAKAALFALQNLFEEKYAPRPIFISGTIVDKSGRTLSGQTGEGFVISVSHGEPLWILLWMAW 262
BLAST of Methionine synthase vs. Ensembl Celegans
Match: metr-1 (Probable methionine synthase [Source:UniProtKB/Swiss-Prot;Acc:Q09582]) HSP 1 Score: 1543.1 bits (3994), Expect = 0.000e+0 Identity = 765/1257 (60.86%), Postives = 982/1257 (78.12%), Query Frame = 3
Query: 42 KSVLFSTL----RERIMILDGAMGTMIQTYKLEENDFRGEIFKDHPKLLRGNNDLLSLTKPDIVFNIHKEFLDSGADIIETNTFSGTAIAQADYGLEHMVYKLNYESAILARKACDLVSSKSGISRFVAGAIGPTNRTLSISPSVEKPEYRNITFDQLVTAYKEQAHALLDGGVDILLIETIFDTANAKAAVFALFEVFEEAGY-EVPVFISGTIVDKSGRNLSGQTTEAFLTSISHIKPICIGLNCALGASDMRPFIETISANTTSFVICYPNAGLPNTFGAYDEKPEYTGEILSQFAKDGLINIVGGCCGTTPAHIAAIKKAVRGYSPRIPPTTLFEDCLVLSGLERFIINPRTTLFVNIGERCNVAGSRRFLRLIKTDKYEEALSIAKEQVENGAQVIDLNMDEGMLEGKLAMTKFINLISSEPDISKVPLCIDSSNFAVIEAGLKCTQGKCIVNSISLKEGELDFYRKLKIIKKFGAAVVIMAFDEQGQAADYDRKIAICCRIYDLLVNKMDFNPNDIIFDLNILTIGTGMEEHNGYGMDFIRATEFVKKNLPHAKVSGGVSNISFSFRGKEVVREAMHSVFLFHAIKAGMDMGIVNAGCLPVYDDIEPRLLELCEDILWNKRQDATDRLLEYAENLLKSDDVGILKTEDAWRSLSVSERLEHSLVKGIDKYIIEDTEEARKC---HVRPLHVIEGPLMRGMSTVGDLFGAGKMFLPQVIKSARVMKRAVGYLIPFMEEEKRLAMEVSGIYSNEPQYVGTMVIATVKGDVHDIGKNIVGVVMGCNNYRVIDLGVMCPSEKILQCALEEKADVIGLSGLITPSLEEMMHVAREMERLGMRTPLLIGGATTSRQHTAVKIAPKYSGPTVHVLDASKSVVVTNSLLDDTXXXXXXXXXXXXXXXXXXXXXXSLAERIYLSIDEARKRKLQLNWSIDHFQSHRPNFLGSKIVENIDINILLPYIDWKPFFDVWQLRGKYPNRGYPKIFNDKDVGKEAQILFSDAQKVLFEIIQYKLLHVNGVIGFYPAHSEGDDILLYDPDSFNVNRKNHLTTLFGLRQQEERE-DPNYLCISDFIAPIESGC-DDYVGMFAVTAGIGADSLAQKFQDQGDDYNSLMVKALADRLAEASAEYLHHIVRTTLWGYSPNENLTPEDYIKVMYDGIRPAPGYPTQPDHSEQATVWDLLKPERIGINLHKDSLGMSPAASVSGLYFSHPKSKYFSVGKISKDQVYDYAKRKQISIGESEKRLQSILSYETD 3782
+S LF L +ERIMI+DGAMGTMIQ +EE DFRGEI KDH K L+GNNDLLS+T+PDI++ IHK +L++GAD +ETNTFSGT IAQADY EH+V+++NY+SA++AR+ACD V + +G R+V GAIGPTNRTLSISPSVEKP++RN+TF +LV AY +QA +L+ GGVD+LL+ET+FD+ANAKAA+FA+ +FE+ G E+PVF+SGTIVD SGR LSGQT EAFL S KP+ +GLNCALGA DMR F++ +S + SF+ICYPNAGLPN G YDE PE ++L +FA+DGL+NI+GGCCGTTP HI A+ KAV+G +PR+PP ++LSGLE I+ P T FVNIGERCNVAGSRRF LIK + Y+ A+ +A+ QV++GAQ++D+NMD+G+L+G AM+KF+ LISSEPD++K+P+CIDSS+F VI AGL+ TQGKC+VNSISLKEGE F + +IIK++GAAVV+MAFDEQGQAA+ D K IC R Y +L ++ FNPNDIIFD NILTI TGMEEH+ YGM FI A +++NLP A VSGGVSNISFSFRG E +REAMHSVFLF+AIKAGMDMGIVNAG LPVY+DI+ LL+L ED+L+N+ +AT++LL A+ + K KT D WRSL+V ERL+ +LVKG+D++++ DTEEAR+ + RPL+VIE PLM GM+ VG+LFGAGKMFLPQVIKSARVMK+AV +L+PFME E++ +E G+ +E Y GT+VIATVKGDVHDIGKNIV VV+GCNN++V+DLGVM P E I++ A+EEKAD IGLSGLITPSL+EM++VA+EM R+G+ PLLIGGATTS+ HTAVKI+P+Y P VH LDASKSVVV +SL D + F +++ E+YE++R+EHY SL +R + +++ R++K +++W D F + +P+F+G + +N D+N L+PYIDWKPFFDVWQLRGKYPNR YPKIF+D DVG EA+ +F DAQ L ++I K+L N V+ F PA SEGDD+ +YDP++ N L T +GLRQQ RE D + C+SDFI P+++G DDY+G+FA TAG+GA+ + + DDY S+MVKALADRLAEA AEYLH VRTTLWGYS NE+LT D + + Y GIRPA GYP+QPDH+E+ T+W LL+ E+ GI L + L M PAASVSGLYF++P+S+YF+VGKI +DQV DYA RK + E E+ L IL Y+TD
Sbjct: 3 RSSLFEELAEIAKERIMIIDGAMGTMIQREYMEEEDFRGEILKDHDKPLKGNNDLLSITRPDIIYKIHKLYLEAGADFVETNTFSGTTIAQADYRCEHLVHEINYQSALVARRACDDVGAATGRRRYVCGAIGPTNRTLSISPSVEKPDFRNVTFQELVKAYGDQARSLIQGGVDVLLVETVFDSANAKAALFAIRTLFEDEGVPEMPVFLSGTIVDMSGRTLSGQTGEAFLVSTKQGKPMAVGLNCALGAKDMRQFVDNMSKWSDSFIICYPNAGLPNALGGYDETPEEMADVLREFARDGLVNIIGGCCGTTPDHINAMYKAVQGITPRVPPQDPHAGKMLLSGLEPSIVGPETN-FVNIGERCNVAGSRRFCNLIKNENYDTAIDVARVQVDSGAQILDVNMDDGLLDGPYAMSKFLRLISSEPDVAKIPVCIDSSDFDVIIAGLESTQGKCVVNSISLKEGEEKFKERARIIKRYGAAVVVMAFDEQGQAAETDPKFEICERSYRILTEEVGFNPNDIIFDANILTIATGMEEHSNYGMYFIEAARMIRENLPGAHVSGGVSNISFSFRGMEAIREAMHSVFLFYAIKAGMDMGIVNAGALPVYEDIDKPLLQLLEDLLFNRDPEATEKLLVAAQEMKKDGKKADTKT-DEWRSLTVEERLKFALVKGVDQFVVADTEEARQNTAKYPRPLNVIERPLMDGMAVVGELFGAGKMFLPQVIKSARVMKKAVAHLLPFMEIERQANIETMGLAEDESPYQGTVVIATVKGDVHDIGKNIVSVVLGCNNFKVVDLGVMTPCENIIKAAIEEKADFIGLSGLITPSLDEMVYVAKEMNRVGLNIPLLIGGATTSKTHTAVKISPRYPHPVVHCLDASKSVVVCSSLSDMSVRDAFLQDLNEDYEDVRQEHYASLKDRRFTDLNKTREKKFKIDW--DKFTAVKPSFVGRREYQNFDLNELIPYIDWKPFFDVWQLRGKYPNRSYPKIFDDADVGAEAKKVFDDAQTWLKKLIDEKILVANAVVSFLPAASEGDDMHVYDPET-----GNKLDTFYGLRQQSGREHDQPHFCLSDFIKPLKNGVPDDYLGLFACTAGLGAEEYCKTLEKNHDDYASIMVKALADRLAEAYAEYLHKEVRTTLWGYSTNEDLTESDLLSIKYQGIRPACGYPSQPDHTEKRTLWKLLEAEKNGIGL-TEHLAMLPAASVSGLYFANPQSEYFAVGKIDQDQVIDYAARKNVPKEEVERWLSPILGYDTD 1249
BLAST of Methionine synthase vs. Ensembl Fly
Match: CG10623 (gene:FBgn0032727 transcript:FBtr0344844) HSP 1 Score: 65.855 bits (159), Expect = 7.690e-11 Identity = 76/290 (26.21%), Postives = 127/290 (43.79%), Query Frame = 3
Query: 204 TKPDIVFNIHKEFLDSGADIIETNTFSGTAIAQADY-GL-EHMVYKLNYESAILARKACDLVSSKSGISR-----FVAGAIGPTNRTLSISPSVEKPEYRNITFDQLVTAYKEQAHALLDGGVDILLIETIFDTANAKAAVFALFEVFEEAGYEVPVFISGTIVDKSGRNLSGQTTEAFLTSISHIKP-------ICIGLNCA--LGASDMRPFIETISANTTSFVICYPNAGLPNTFGAYD-EKPEY--TGEILSQFAKDGL---INIVGGCCGTTPAHIAAIKKAVRG 1007
T P+ V H +FL +GADII TNT+ + Y G+ +L +S LA++A + S+ G + G+IGP L ++ ++L +K + L GVD L +ET+ A+A + + F +A + V + SG N + EA L+ ++ + IGLNC L + + + ++ + ++ Y N G YD E+ ++ TGE + +F + + + IVGGCC P + AI+K V G
Sbjct: 46 TNPEAVIQTHLDFLRNGADIILTNTYQSSVEGFVKYLGVTRERGVELIQKSVQLAKQAKEQYLSEIGSEAESALPLIMGSIGPYGAYLHDGSEYTGNYADKMSKEELRAWHKTRIEICLAAGVDGLALETLPCLMEAEAVTELVLDNFPDAKFWVSLQCMDEKHMASGENFA----EAALSLWRLVQSRKAENRLLGIGLNCVNPLFVTPLLSSLTKVAGSDRIPLVVYSNRG-----EIYDVEQGDWTGTGEEVVKFVPEWIQLGVRIVGGCCRVYPTDVLAIRKYVDG 326
BLAST of Methionine synthase vs. Ensembl Fly
Match: CG10623 (gene:FBgn0032727 transcript:FBtr0344845) HSP 1 Score: 65.855 bits (159), Expect = 7.690e-11 Identity = 76/290 (26.21%), Postives = 127/290 (43.79%), Query Frame = 3
Query: 204 TKPDIVFNIHKEFLDSGADIIETNTFSGTAIAQADY-GL-EHMVYKLNYESAILARKACDLVSSKSGISR-----FVAGAIGPTNRTLSISPSVEKPEYRNITFDQLVTAYKEQAHALLDGGVDILLIETIFDTANAKAAVFALFEVFEEAGYEVPVFISGTIVDKSGRNLSGQTTEAFLTSISHIKP-------ICIGLNCA--LGASDMRPFIETISANTTSFVICYPNAGLPNTFGAYD-EKPEY--TGEILSQFAKDGL---INIVGGCCGTTPAHIAAIKKAVRG 1007
T P+ V H +FL +GADII TNT+ + Y G+ +L +S LA++A + S+ G + G+IGP L ++ ++L +K + L GVD L +ET+ A+A + + F +A + V + SG N + EA L+ ++ + IGLNC L + + + ++ + ++ Y N G YD E+ ++ TGE + +F + + + IVGGCC P + AI+K V G
Sbjct: 46 TNPEAVIQTHLDFLRNGADIILTNTYQSSVEGFVKYLGVTRERGVELIQKSVQLAKQAKEQYLSEIGSEAESALPLIMGSIGPYGAYLHDGSEYTGNYADKMSKEELRAWHKTRIEICLAAGVDGLALETLPCLMEAEAVTELVLDNFPDAKFWVSLQCMDEKHMASGENFA----EAALSLWRLVQSRKAENRLLGIGLNCVNPLFVTPLLSSLTKVAGSDRIPLVVYSNRG-----EIYDVEQGDWTGTGEEVVKFVPEWIQLGVRIVGGCCRVYPTDVLAIRKYVDG 326
BLAST of Methionine synthase vs. Ensembl Fly
Match: CG10623 (gene:FBgn0032727 transcript:FBtr0081190) HSP 1 Score: 65.855 bits (159), Expect = 7.690e-11 Identity = 76/290 (26.21%), Postives = 127/290 (43.79%), Query Frame = 3
Query: 204 TKPDIVFNIHKEFLDSGADIIETNTFSGTAIAQADY-GL-EHMVYKLNYESAILARKACDLVSSKSGISR-----FVAGAIGPTNRTLSISPSVEKPEYRNITFDQLVTAYKEQAHALLDGGVDILLIETIFDTANAKAAVFALFEVFEEAGYEVPVFISGTIVDKSGRNLSGQTTEAFLTSISHIKP-------ICIGLNCA--LGASDMRPFIETISANTTSFVICYPNAGLPNTFGAYD-EKPEY--TGEILSQFAKDGL---INIVGGCCGTTPAHIAAIKKAVRG 1007
T P+ V H +FL +GADII TNT+ + Y G+ +L +S LA++A + S+ G + G+IGP L ++ ++L +K + L GVD L +ET+ A+A + + F +A + V + SG N + EA L+ ++ + IGLNC L + + + ++ + ++ Y N G YD E+ ++ TGE + +F + + + IVGGCC P + AI+K V G
Sbjct: 46 TNPEAVIQTHLDFLRNGADIILTNTYQSSVEGFVKYLGVTRERGVELIQKSVQLAKQAKEQYLSEIGSEAESALPLIMGSIGPYGAYLHDGSEYTGNYADKMSKEELRAWHKTRIEICLAAGVDGLALETLPCLMEAEAVTELVLDNFPDAKFWVSLQCMDEKHMASGENFA----EAALSLWRLVQSRKAENRLLGIGLNCVNPLFVTPLLSSLTKVAGSDRIPLVVYSNRG-----EIYDVEQGDWTGTGEEVVKFVPEWIQLGVRIVGGCCRVYPTDVLAIRKYVDG 326
BLAST of Methionine synthase vs. Ensembl Fly
Match: CG10621 (gene:FBgn0032726 transcript:FBtr0081191) HSP 1 Score: 50.0618 bits (118), Expect = 8.692e-6 Identity = 73/340 (21.47%), Postives = 133/340 (39.12%), Query Frame = 3
Query: 72 RIMILDGAMGTMIQTYKLEENDFRGEIFKDHPKLLRGNNDLLSLTKPDIVFNIHKEFLDSGADIIETNTFSGTAIAQADYGL--EHMVYKLNYESAILARKACD---------LVSSKSGISRFVAGAIGPTNRTLSISPSVEKPEYRNITFDQLVTAYKEQAHALLDGGVDILLIETIFDTANAKAAVFALFEVFEEAGYEVPVFISGTIVDKSGRNLSGQTT---EAFLTSISHIKPICIGLNCALGASDMRPFIETISANTTSF----VICYPNAGLPNTFGAYDEKPEYTGE--------ILSQFAKDGLINIVGGCCGTTPAHIAAIKKAVRGYS 1013
R+++ DG GT + + G+ P + + T P + + H +FL +GADII TNT+ + +Y E +L + LA A + +S + G +A +IGP L + ++ ++ + A L+ GVD L IETI A+A V L + + + + V G + + + K + IG+NC + + P ++++ + ++ YPN+G YD + G + ++A+ G ++GGCC T I I +A+R ++
Sbjct: 5 RVLVKDGGFGTQMTVHV-------GDSVDGDPLW----SARFNATNPAAIISTHLDFLQNGADIILTNTYQSSVDGYMEYLELDEEQSIELIKNTVRLAHIAKERYLTECYQAQLSVQEGYPLIIA-SIGPFGAHLHDGSEYTGSYADFVPAKEITDWHRVRIEACLEAGVDALAIETIPCQMEAEALVEMLCDDYPDVKFWVAFQCKDENTLAHGETFADAANAIWDLLAERNAQDKCLAIGVNC-VHPKFVTPLFKSLNGDREVGEQIPLVVYPNSG-----EVYDVVNGWQGREHCVPLANYVPEWAQLG-AKVIGGCCRTYARDIRHIGEAIRDWN 325
BLAST of Methionine synthase vs. Ensembl Fly
Match: CG10621 (gene:FBgn0032726 transcript:FBtr0342926) HSP 1 Score: 50.0618 bits (118), Expect = 8.692e-6 Identity = 73/340 (21.47%), Postives = 133/340 (39.12%), Query Frame = 3
Query: 72 RIMILDGAMGTMIQTYKLEENDFRGEIFKDHPKLLRGNNDLLSLTKPDIVFNIHKEFLDSGADIIETNTFSGTAIAQADYGL--EHMVYKLNYESAILARKACD---------LVSSKSGISRFVAGAIGPTNRTLSISPSVEKPEYRNITFDQLVTAYKEQAHALLDGGVDILLIETIFDTANAKAAVFALFEVFEEAGYEVPVFISGTIVDKSGRNLSGQTT---EAFLTSISHIKPICIGLNCALGASDMRPFIETISANTTSF----VICYPNAGLPNTFGAYDEKPEYTGE--------ILSQFAKDGLINIVGGCCGTTPAHIAAIKKAVRGYS 1013
R+++ DG GT + + G+ P + + T P + + H +FL +GADII TNT+ + +Y E +L + LA A + +S + G +A +IGP L + ++ ++ + A L+ GVD L IETI A+A V L + + + + V G + + + K + IG+NC + + P ++++ + ++ YPN+G YD + G + ++A+ G ++GGCC T I I +A+R ++
Sbjct: 5 RVLVKDGGFGTQMTVHV-------GDSVDGDPLW----SARFNATNPAAIISTHLDFLQNGADIILTNTYQSSVDGYMEYLELDEEQSIELIKNTVRLAHIAKERYLTECYQAQLSVQEGYPLIIA-SIGPFGAHLHDGSEYTGSYADFVPAKEITDWHRVRIEACLEAGVDALAIETIPCQMEAEALVEMLCDDYPDVKFWVAFQCKDENTLAHGETFADAANAIWDLLAERNAQDKCLAIGVNC-VHPKFVTPLFKSLNGDREVGEQIPLVVYPNSG-----EVYDVVNGWQGREHCVPLANYVPEWAQLG-AKVIGGCCRTYARDIRHIGEAIRDWN 325
BLAST of Methionine synthase vs. Ensembl Zebrafish
Match: mtr (5-methyltetrahydrofolate-homocysteine methyltransferase [Source:ZFIN;Acc:ZDB-GENE-031001-5]) HSP 1 Score: 1315.44 bits (3403), Expect = 0.000e+0 Identity = 643/987 (65.15%), Postives = 800/987 (81.05%), Query Frame = 3
Query: 51 LFSTLRERIMILDGAMGTMIQTYKLEENDFRGEIFKDHPKLLRGNNDLLSLTKPDIVFNIHKEFLDSGADIIETNTFSGTAIAQADYGLEHMVYKLNYESAILARKACDLVSSKSGISRFVAGAIGPTNRTLSISPSVEKPEYRNITFDQLVTAYKEQAHALLDGGVDILLIETIFDTANAKAAVFALFEVFEEAGYEVPVFISGTIVDKSGRNLSGQTTEAFLTSISHIKPICIGLNCALGASDMRPFIETISANTTSFVICYPNAGLPNTFGAYDEKPEYTGEILSQFAKDGLINIVGGCCGTTPAHIAAIKKAVRGYSPRIPPTTLFEDCLVLSGLERFIINPRTTLFVNIGERCNVAGSRRFLRLIKTDKYEEALSIAKEQVENGAQVIDLNMDEGMLEGKLAMTKFINLISSEPDISKVPLCIDSSNFAVIEAGLKCTQGKCIVNSISLKEGELDFYRKLKIIKKFGAAVVIMAFDEQGQAADYDRKIAICCRIYDLLVNKMDFNPNDIIFDLNILTIGTGMEEHNGYGMDFIRATEFVKKNLPHAKVSGGVSNISFSFRGKEVVREAMHSVFLFHAIKAGMDMGIVNAGCLPVYDDIEPRLLELCEDILWNKRQDATDRLLEYAENLLKSDDVGILKTEDAWRSLSVSERLEHSLVKGIDKYIIEDTEEAR---KCHVRPLHVIEGPLMRGMSTVGDLFGAGKMFLPQVIKSARVMKRAVGYLIPFMEEEKRLAMEVSGIYSNEPQYVGTMVIATVKGDVHDIGKNIVGVVMGCNNYRVIDLGVMCPSEKILQCALEEKADVIGLSGLITPSLEEMMHVAREMERLGMRTPLLIGGATTSRQHTAVKIAPKYSGPTVHVLDASKSVVVTNSLLDDTXXXXXXXXXXXXXXXXXXXXXXSLAERIYLSIDEARKRKLQLNWSIDHFQSHRPNFLGSKIVENIDINILLPYIDWKPFFDVWQLRGKYPNRGYPKIFNDKDVGK 3002
L L++RI++LDG MGTMIQ LEE +FRG+ FKDHPK L+GNND+LS+T+PD++++IHKE+L++GADIIETNTFS T+IAQADYG+E + Y+LN SA +AR+A D VS+++G RFVAGA+GPTN+TLS+SPSVE+P+YRNITFD+LV AY EQ LLDGG D+LL+ETIFDTANAKAA+FA+ +FEE+ PV ISGTIVDKSGR LSGQT EAF+ S+SH +P+CIGLNCALGAS+MRPFIE I +T++FVICYPNAGLPNTFG YDE P+ T L +FA DGL+NIVGGCCGTTP HI AI ++VR PR+PPT ++ D ++LSGLE F I P T FVNIGERCNVAGSR+F +LI YE A + K ++ G+Q+ D N G L+G AM++F NLI+SEPDI KVPLCIDSSNF+VIEAGLKC QGKCIVNSISLKEGE DF R+ + ++++GAAVV+MAFDE GQA + D+K+ IC R Y LL+++ FNPNDIIFD NILTIGTGMEEH+ Y ++FIRAT +K++LP A+VSGG+SN+SFSFRG E +REAMH FL+HAIK GMDMGIVNAG LPVYDDI+ LL LCE+I+WN+ DAT++LL YA+N K +++T D WR+ SV ERLE++LVKGI+KY++EDTEEAR + + RPLHVIEGPLM GM TVGDLFGAGKMFLPQVIKSARVMK+AVG+LIPFME+E+ M SG Y GT+++ATVKGDVHDIGKNIVGVV+GCNN+RVIDLGVM P ++IL+ A+ KAD+IGLSGLITPSL+EM+HVA+EMERLG++ PLLIGGATTS+ HTAVKIAP+YS P VHVLDAS+SVVV + LLD+ ++ E +QEEYE+IR++HY+SL +R +LS+ AR++ L ++W + + RP FLG+ + + D+ L+ +IDWKPFFDVWQLRGKYPNRGYPKIF DK VG+
Sbjct: 20 LTELLQQRILVLDGGMGTMIQQRHLEEEEFRGQEFKDHPKSLKGNNDILSITQPDVIYSIHKEYLEAGADIIETNTFSSTSIAQADYGMEDLAYRLNKASAEVARRAADDVSAQTGCKRFVAGALGPTNKTLSVSPSVERPDYRNITFDELVEAYAEQVKGLLDGGADVLLVETIFDTANAKAALFAIDRLFEESYEARPVLISGTIVDKSGRTLSGQTGEAFVISVSHTQPLCIGLNCALGASEMRPFIEAIGKSTSAFVICYPNAGLPNTFGGYDETPDVTAAHLKEFAVDGLVNIVGGCCGTTPDHIRAIAESVRHVKPRVPPTDVYSDYMLLSGLEPFRIGPYTN-FVNIGERCNVAGSRKFAKLIMAGNYEPAGASPKCTLKLGSQICDRNNTRGFLDGAAAMSRFCNLIASEPDICKVPLCIDSSNFSVIEAGLKCCQGKCIVNSISLKEGEQDFLRRARQVRRYGAAVVVMAFDEDGQATETDQKVQICSRAYHLLIDQAGFNPNDIIFDPNILTIGTGMEEHSMYAINFIRATRIIKESLPGARVSGGLSNLSFSFRGMEAIREAMHGAFLYHAIKDGMDMGIVNAGNLPVYDDIDKELLLLCENIIWNRDPDATEKLLLYAQNNAKGGK-KVVQT-DEWRTGSVEERLEYALVKGIEKYVVEDTEEARAQTERYPRPLHVIEGPLMNGMKTVGDLFGAGKMFLPQVIKSARVMKKAVGHLIPFMEKEREEMMATSGCVEEVDPYQGTVLLATVKGDVHDIGKNIVGVVLGCNNFRVIDLGVMIPCDRILREAIHNKADIIGLSGLITPSLDEMIHVAKEMERLGLKIPLLIGGATTSKTHTAVKIAPRYSSPVVHVLDASRSVVVCSQLLDEGVRDDYFEEVQEEYEDIRQDHYDSLKDRRFLSLSRAREKGLHIDW-LAQPKPVRPQFLGTHVFDTYDLRKLVDFIDWKPFFDVWQLRGKYPNRGYPKIFKDKTVGQ 1002 HSP 2 Score: 222.631 bits (566), Expect = 1.496e-58 Identity = 114/189 (60.32%), Postives = 140/189 (74.07%), Query Frame = 3
Query: 3219 YLCISDFIAPIESGCDDYVGMFAVTAGIGADSLAQKFQDQGDDYNSLMVKALADRLAEASAEYLHHIVRTTLWGYSPNENLTPEDYIKVMYDGIRPAPGYPTQPDHSEQATVWDLLK-PERIGINLHKDSLGMSPAASVSGLYFSHPKSKYFSVGKISKDQVYDYAKRKQISIGESEKRLQSILSYETD 3782
++C+ AP SG DYVG+FAV+ GA+ L+QKF+ QGDDY S+MVKALADRLAEA AE LH VR LWGYS E+L D K+ Y+GIRPA GYP+QPDHSE+ T+W L E+ GI+L +SL MSPAASVSGLYFS+PKS YF+VGKI+K+QV DYA RKQ+ + E E+ L IL Y+TD
Sbjct: 1077 HVCLKRGCAPRSSGVQDYVGLFAVSV-FGAEELSQKFEKQGDDYRSIMVKALADRLAEAFAEELHVRVRRDLWGYSSEEDLPASDLHKLRYEGIRPAAGYPSQPDHSEKLTMWKLADIQEKTGISL-TESLAMSPAASVSGLYFSNPKSAYFAVGKITKEQVEDYALRKQMEVCEVERWLGPILGYDTD 1263
BLAST of Methionine synthase vs. Ensembl Zebrafish
Match: zgc:172121 (zgc:172121 [Source:ZFIN;Acc:ZDB-GENE-030131-9545]) HSP 1 Score: 68.1662 bits (165), Expect = 1.285e-11 Identity = 69/279 (24.73%), Postives = 126/279 (45.16%), Query Frame = 3
Query: 204 TKPDIVFNIHKEFLDSGADIIETNTFSGTAIAQADY-GLEHMVYKLNYESAI-LARKACDLVSSKSGISR----FVAGAIGPTNRTLSISPSVEKPEYRNITFDQLVTAYKEQAHALLDGGVDILLIETIFDTANAKAAVFALFEVFEEAGYEVPVFISGTIVDKSGRNLSGQTTEAFLTSISHIKPICIGLNCALGASDMRPFIETISANTT---SFVICYPNAGLPNTFGAYDEKPEYTGEILSQFAKDGL------INIVGGCCGTTPAHIAAIKK 995
T + ++H +L SG+D+I T T+ + Y G++ + SA+ LA++ S+S +S VAG++GP L +T ++L ++ Q L+ G D++ +ETI A+ AL EV +E E ++S + D + + + +EA + + + +G+NC A ++P +E+ ++ S+V+ YPN+G +D + E+ + FA L +GGCC PA I +K+
Sbjct: 36 TDSQAIKDVHYRYLQSGSDVITTATYQASIEGFVKYLGVQPEEAQHMMMSAVQLAKETVSEFISQSPMSDRREPLVAGSVGPYGSFLHDGSEYTGAYEDKMTVEELKDWHRPQIQCLVKAGADLVAMETIPGLKEAE----ALVEVLKEFP-ETKAWLSFSCKDNNSISSGRRFSEAVEMACRSTQLVAVGVNCC-PALLVKPLLESAKSHKRADLSWVV-YPNSG-----EGWDVTTGWKTEMRTSFANLSLEWKAQGALWIGGCCRVRPADITELKQ 302
BLAST of Methionine synthase vs. Ensembl Zebrafish
Match: zgc:172121 (zgc:172121 [Source:ZFIN;Acc:ZDB-GENE-030131-9545]) HSP 1 Score: 68.1662 bits (165), Expect = 1.285e-11 Identity = 69/279 (24.73%), Postives = 126/279 (45.16%), Query Frame = 3
Query: 204 TKPDIVFNIHKEFLDSGADIIETNTFSGTAIAQADY-GLEHMVYKLNYESAI-LARKACDLVSSKSGISR----FVAGAIGPTNRTLSISPSVEKPEYRNITFDQLVTAYKEQAHALLDGGVDILLIETIFDTANAKAAVFALFEVFEEAGYEVPVFISGTIVDKSGRNLSGQTTEAFLTSISHIKPICIGLNCALGASDMRPFIETISANTT---SFVICYPNAGLPNTFGAYDEKPEYTGEILSQFAKDGL------INIVGGCCGTTPAHIAAIKK 995
T + ++H +L SG+D+I T T+ + Y G++ + SA+ LA++ S+S +S VAG++GP L +T ++L ++ Q L+ G D++ +ETI A+ AL EV +E E ++S + D + + + +EA + + + +G+NC A ++P +E+ ++ S+V+ YPN+G +D + E+ + FA L +GGCC PA I +K+
Sbjct: 36 TDSQAIKDVHYRYLQSGSDVITTATYQASIEGFVKYLGVQPEEAQHMMMSAVQLAKETVSEFISQSPMSDRREPLVAGSVGPYGSFLHDGSEYTGAYEDKMTVEELKDWHRPQIQCLVKAGADLVAMETIPGLKEAE----ALVEVLKEFP-ETKAWLSFSCKDNNSISSGRRFSEAVEMACRSTQLVAVGVNCC-PALLVKPLLESAKSHKRADLSWVV-YPNSG-----EGWDVTTGWKTEMRTSFANLSLEWKAQGALWIGGCCRVRPADITELKQ 302
BLAST of Methionine synthase vs. Ensembl Zebrafish
Match: zgc:172121 (zgc:172121 [Source:ZFIN;Acc:ZDB-GENE-030131-9545]) HSP 1 Score: 68.1662 bits (165), Expect = 1.285e-11 Identity = 69/279 (24.73%), Postives = 126/279 (45.16%), Query Frame = 3
Query: 204 TKPDIVFNIHKEFLDSGADIIETNTFSGTAIAQADY-GLEHMVYKLNYESAI-LARKACDLVSSKSGISR----FVAGAIGPTNRTLSISPSVEKPEYRNITFDQLVTAYKEQAHALLDGGVDILLIETIFDTANAKAAVFALFEVFEEAGYEVPVFISGTIVDKSGRNLSGQTTEAFLTSISHIKPICIGLNCALGASDMRPFIETISANTT---SFVICYPNAGLPNTFGAYDEKPEYTGEILSQFAKDGL------INIVGGCCGTTPAHIAAIKK 995
T + ++H +L SG+D+I T T+ + Y G++ + SA+ LA++ S+S +S VAG++GP L +T ++L ++ Q L+ G D++ +ETI A+ AL EV +E E ++S + D + + + +EA + + + +G+NC A ++P +E+ ++ S+V+ YPN+G +D + E+ + FA L +GGCC PA I +K+
Sbjct: 36 TDSQAIKDVHYRYLQSGSDVITTATYQASIEGFVKYLGVQPEEAQHMMMSAVQLAKETVSEFISQSPMSDRREPLVAGSVGPYGSFLHDGSEYTGAYEDKMTVEELKDWHRPQIQCLVKAGADLVAMETIPGLKEAE----ALVEVLKEFP-ETKAWLSFSCKDNNSISSGRRFSEAVEMACRSTQLVAVGVNCC-PALLVKPLLESAKSHKRADLSWVV-YPNSG-----EGWDVTTGWKTEMRTSFANLSLEWKAQGALWIGGCCRVRPADITELKQ 302
BLAST of Methionine synthase vs. Ensembl Xenopus
Match: smap2 (small ArfGAP2 [Source:Xenbase;Acc:XB-GENE-5817085]) HSP 1 Score: 1618.59 bits (4190), Expect = 0.000e+0 Identity = 805/1260 (63.89%), Postives = 995/1260 (78.97%), Query Frame = 3
Query: 30 RKNIKSVLFSTLRERIMILDGAMGTMIQTYKLEENDFRGEIFKDHPKLLRGNNDLLSLTKPDIVFNIHKEFLDSGADIIETNTFSGTAIAQADYGLEHMVYKLNYESAILARKACDLVSSKSGISRFVAGAIGPTNRTLSISPSVEKPEYRNITFDQLVTAYKEQAHALLDGGVDILLIETIFDTANAKAAVFALFEVFEEAGYEVPVFISGTIVDKSGRNLSGQTTEAFLTSISHIKPICIGLNCALGASDMRPFIETISANTTSFVICYPNAGLPNTFGAYDEKPEYTGEILSQFAKDGLINIVGGCCGTTPAHIAAIKKAVRGYSPRIPPTTLFEDCLVLSGLERFIINPRTTLFVNIGERCNVAGSRRFLRLIKTDKYEEALSIAKEQVENGAQVIDLNMDEGMLEGKLAMTKFINLISSEPDISKVPLCIDSSNFAVIEAGLKCTQGKCIVNSISLKEGELDFYRKLKIIKKFGAAVVIMAFDEQGQAADYDRKIAICCRIYDLLVNKMDFNPNDIIFDLNILTIGTGMEEHNGYGMDFIRATEFVKKNLPHAKVSGGVSNISFSFRGKEVVREAMHSVFLFHAIKAGMDMGIVNAGCLPVYDDIEPRLLELCEDILWNKRQDATDRLLEYAENLLKSDDVGILKTEDAWRSLSVSERLEHSLVKGIDKYIIEDTEEAR---KCHVRPLHVIEGPLMRGMSTVGDLFGAGKMFLPQVIKSARVMKRAVGYLIPFMEEEKRLAMEVSGIYSNEPQYVGTMVIATVKGDVHDIGKNIVGVVMGCNNYRVIDLGVMCPSEKILQCALEEKADVIGLSGLITPSLEEMMHVAREMERLGMRTPLLIGGATTSRQHTAVKIAPKYSGPTVHVLDASKSVVVTNSLLDDTXXXXXXXXXXXXXXXXXXXXXXSLAERIYLSIDEARKRKLQLNWSIDHFQSHRPNFLGSKIVENIDINILLPYIDWKPFFDVWQLRGKYPNRGYPKIFNDKDVGKEAQILFSDAQKVLFEIIQYKLLHVNGVIGFYPAHSEGDDILLYDPDSFNVNRKNHLTTLFGLRQQEERE----DPNYLCISDFIAPIESGCDDYVGMFAVTAGIGADSLAQKFQDQGDDYNSLMVKALADRLAEASAEYLHHIVRTTLWGYSPNENLTPEDYIKVMYDGIRPAPGYPTQPDHSEQATVWDLLKPER-IGINLHKDSLGMSPAASVSGLYFSHPKSKYFSVGKISKDQVYDYAKRKQISIGESEKRLQSILSYETDE 3785
++N++ L S LRERIM+LDG MGTMIQ + L+E FRG+ F DH K L+GNNDLLS+T+ +I++ IHKE+L GADI+ETNTFS T+IAQADYGLEH+ Y+LN SA +AR+A D V++++G+ R+VAGA+GPTN+TLS+SPSVE+P+YRN+TFD+LV AY EQA LLDGGVDILL+ETIFDTANAKAA+FA+ ++FEE P+FISGTIVDKSGR LSGQT EAF+ S+SH +P+CIGLNCALGA +MRPFIE I TTS+VICYPNAGLPNTFG YDE PE T + + FA DGL+NIVGGCCGTTPAHI I +AV+ PRIPPT++F+ ++LSGLE F I P T FVNIGERCNVAGSRRF +LI +D YEEALS+AK QVE GAQ++D+N+D+GML+G AM +F N I+SEPDI+KVPLCIDSSNF VIEAGLKC QGKCIVNSISLKEGE DF K K IK+FGAAVVIMAFDE GQA D + K+++C R Y+LLV K++FNPNDIIFD NILTIGTGMEEH+ Y ++FI AT+ +K++L A+VSGG+SN+SFSFRG E +REAMH VFL+HAIKAGMDMGIVNAG LPVYDDI+ LL LCED++WN+ D T++LL+YA+ K +++T D WR+ SV ERLE++L+KGI+K++IEDTEEAR + + RPLH+IEGPLM GM VG+LFGAGKMFLPQVIKSARVMK++VG+LIPFME+E+ +SG + Y GT+V+ATVKGDVHDIGKNIVGVV+GCNN+RVIDLGVM P +KIL+ A+E KAD+IGLSGLITPSL+EM+ VA+EMERLG+RTPLLIGGATTSR HTAVKIAP+Y+ P +H LDASKSVVV + LLD+ +F E I EEYE+IR++HYESL ER YL++++AR + L ++W + H + RP +G+++ N D+ L YIDWKPFFDVWQLRGKYPNR +PKIFNDK VG+EA+ L+ DAQ +L +I K GV+G +PAHS DDILLY D N++ + T +GLRQQ E++ DP Y C+SDFIAP SG DY+G+FAV A G + L++ ++ QGDDY+S+M KAL DRL EA AE LH VR LWGY E L D ++ Y+GIRPAPGYP+QPDH E+ T+W L ER GI L +SL MSPA+SVSGL FS P SKYF+VGKISKDQV DYA RK + + E EK L ILSY+ ++
Sbjct: 15 KRNLQEELDSVLRERIMVLDGGMGTMIQQHTLQEESFRGQEFIDHAKPLKGNNDLLSITQSEIIYKIHKEYLTCGADIVETNTFSSTSIAQADYGLEHLAYRLNKVSAEVARRAADDVTAETGMKRYVAGAMGPTNKTLSVSPSVERPDYRNVTFDELVDAYAEQARGLLDGGVDILLVETIFDTANAKAALFAIQKLFEEDYEPRPIFISGTIVDKSGRTLSGQTGEAFVVSVSHAEPLCIGLNCALGAIEMRPFIEAIGKCTTSYVICYPNAGLPNTFGGYDETPEVTAKHIKDFALDGLVNIVGGCCGTTPAHIREIAEAVKNCKPRIPPTSVFDGYMLLSGLEPFRIGPYTN-FVNIGERCNVAGSRRFAKLIMSDNYEEALSVAKAQVEMGAQILDINVDDGMLDGPTAMARFCNYIASEPDIAKVPLCIDSSNFNVIEAGLKCCQGKCIVNSISLKEGEEDFLAKAKKIKQFGAAVVIMAFDEVGQATDTETKVSVCTRAYNLLVEKLNFNPNDIIFDPNILTIGTGMEEHDKYAINFIEATKSIKESLKGARVSGGLSNLSFSFRGMEAIREAMHGVFLYHAIKAGMDMGIVNAGNLPVYDDIDKELLTLCEDLIWNRDPDGTEKLLKYAQTKAKGGK-KVIQT-DEWRNGSVEERLEYALIKGIEKFVIEDTEEARANKEKYSRPLHIIEGPLMNGMKVVGELFGAGKMFLPQVIKSARVMKKSVGHLIPFMEKEREAMRAISGTLEEDNPYQGTIVLATVKGDVHDIGKNIVGVVLGCNNFRVIDLGVMTPCDKILRAAIENKADIIGLSGLITPSLDEMIFVAKEMERLGIRTPLLIGGATTSRTHTAVKIAPRYNAPVIHCLDASKSVVVCSQLLDENVRDDFLEEITEEYEDIRQDHYESLRERRYLTLEQARNKGLHIDW-LSHPKPVRPKLIGTEVYSNYDLEKLRHYIDWKPFFDVWQLRGKYPNRAFPKIFNDKTVGEEAKRLYEDAQNMLNMVISEKKFEARGVVGIWPAHSVQDDILLY-ADEGNMSSTEAIATFYGLRQQAEKDSASTDP-YYCLSDFIAPQHSGVKDYLGVFAV-ACFGVEELSKVYEKQGDDYSSIMAKALGDRLVEAFAEELHERVRKDLWGYCSEEQLNVSDLRRIRYEGIRPAPGYPSQPDHIEKVTMWKLADVERTTGIKL-TESLAMSPASSVSGLMFSSPMSKYFAVGKISKDQVEDYACRKNMPVCEVEKWLGPILSYDPED 1266
BLAST of Methionine synthase vs. Ensembl Xenopus
Match: smap2 (small ArfGAP2 [Source:Xenbase;Acc:XB-GENE-5817085]) HSP 1 Score: 1618.59 bits (4190), Expect = 0.000e+0 Identity = 805/1261 (63.84%), Postives = 996/1261 (78.98%), Query Frame = 3
Query: 27 MRKNIKSVLFSTLRERIMILDGAMGTMIQTYKLEENDFRGEIFKDHPKLLRGNNDLLSLTKPDIVFNIHKEFLDSGADIIETNTFSGTAIAQADYGLEHMVYKLNYESAILARKACDLVSSKSGISRFVAGAIGPTNRTLSISPSVEKPEYRNITFDQLVTAYKEQAHALLDGGVDILLIETIFDTANAKAAVFALFEVFEEAGYEVPVFISGTIVDKSGRNLSGQTTEAFLTSISHIKPICIGLNCALGASDMRPFIETISANTTSFVICYPNAGLPNTFGAYDEKPEYTGEILSQFAKDGLINIVGGCCGTTPAHIAAIKKAVRGYSPRIPPTTLFEDCLVLSGLERFIINPRTTLFVNIGERCNVAGSRRFLRLIKTDKYEEALSIAKEQVENGAQVIDLNMDEGMLEGKLAMTKFINLISSEPDISKVPLCIDSSNFAVIEAGLKCTQGKCIVNSISLKEGELDFYRKLKIIKKFGAAVVIMAFDEQGQAADYDRKIAICCRIYDLLVNKMDFNPNDIIFDLNILTIGTGMEEHNGYGMDFIRATEFVKKNLPHAKVSGGVSNISFSFRGKEVVREAMHSVFLFHAIKAGMDMGIVNAGCLPVYDDIEPRLLELCEDILWNKRQDATDRLLEYAENLLKSDDVGILKTEDAWRSLSVSERLEHSLVKGIDKYIIEDTEEAR---KCHVRPLHVIEGPLMRGMSTVGDLFGAGKMFLPQVIKSARVMKRAVGYLIPFMEEEKRLAMEVSGIYSNEPQYVGTMVIATVKGDVHDIGKNIVGVVMGCNNYRVIDLGVMCPSEKILQCALEEKADVIGLSGLITPSLEEMMHVAREMERLGMRTPLLIGGATTSRQHTAVKIAPKYSGPTVHVLDASKSVVVTNSLLDDTXXXXXXXXXXXXXXXXXXXXXXSLAERIYLSIDEARKRKLQLNWSIDHFQSHRPNFLGSKIVENIDINILLPYIDWKPFFDVWQLRGKYPNRGYPKIFNDKDVGKEAQILFSDAQKVLFEIIQYKLLHVNGVIGFYPAHSEGDDILLYDPDSFNVNRKNHLTTLFGLRQQEERE----DPNYLCISDFIAPIESGCDDYVGMFAVTAGIGADSLAQKFQDQGDDYNSLMVKALADRLAEASAEYLHHIVRTTLWGYSPNENLTPEDYIKVMYDGIRPAPGYPTQPDHSEQATVWDLLKPER-IGINLHKDSLGMSPAASVSGLYFSHPKSKYFSVGKISKDQVYDYAKRKQISIGESEKRLQSILSYETDE 3785
+++N++ L S LRERIM+LDG MGTMIQ + L+E FRG+ F DH K L+GNNDLLS+T+ +I++ IHKE+L GADI+ETNTFS T+IAQADYGLEH+ Y+LN SA +AR+A D V++++G+ R+VAGA+GPTN+TLS+SPSVE+P+YRN+TFD+LV AY EQA LLDGGVDILL+ETIFDTANAKAA+FA+ ++FEE P+FISGTIVDKSGR LSGQT EAF+ S+SH +P+CIGLNCALGA +MRPFIE I TTS+VICYPNAGLPNTFG YDE PE T + + FA DGL+NIVGGCCGTTPAHI I +AV+ PRIPPT++F+ ++LSGLE F I P T FVNIGERCNVAGSRRF +LI +D YEEALS+AK QVE GAQ++D+N+D+GML+G AM +F N I+SEPDI+KVPLCIDSSNF VIEAGLKC QGKCIVNSISLKEGE DF K K IK+FGAAVVIMAFDE GQA D + K+++C R Y+LLV K++FNPNDIIFD NILTIGTGMEEH+ Y ++FI AT+ +K++L A+VSGG+SN+SFSFRG E +REAMH VFL+HAIKAGMDMGIVNAG LPVYDDI+ LL LCED++WN+ D T++LL+YA+ K +++T D WR+ SV ERLE++L+KGI+K++IEDTEEAR + + RPLH+IEGPLM GM VG+LFGAGKMFLPQVIKSARVMK++VG+LIPFME+E+ +SG + Y GT+V+ATVKGDVHDIGKNIVGVV+GCNN+RVIDLGVM P +KIL+ A+E KAD+IGLSGLITPSL+EM+ VA+EMERLG+RTPLLIGGATTSR HTAVKIAP+Y+ P +H LDASKSVVV + LLD+ +F E I EEYE+IR++HYESL ER YL++++AR + L ++W + H + RP +G+++ N D+ L YIDWKPFFDVWQLRGKYPNR +PKIFNDK VG+EA+ L+ DAQ +L +I K GV+G +PAHS DDILLY D N++ + T +GLRQQ E++ DP Y C+SDFIAP SG DY+G+FAV A G + L++ ++ QGDDY+S+M KAL DRL EA AE LH VR LWGY E L D ++ Y+GIRPAPGYP+QPDH E+ T+W L ER GI L +SL MSPA+SVSGL FS P SKYF+VGKISKDQV DYA RK + + E EK L ILSY+ ++
Sbjct: 1 IKRNLQEELDSVLRERIMVLDGGMGTMIQQHTLQEESFRGQEFIDHAKPLKGNNDLLSITQSEIIYKIHKEYLTCGADIVETNTFSSTSIAQADYGLEHLAYRLNKVSAEVARRAADDVTAETGMKRYVAGAMGPTNKTLSVSPSVERPDYRNVTFDELVDAYAEQARGLLDGGVDILLVETIFDTANAKAALFAIQKLFEEDYEPRPIFISGTIVDKSGRTLSGQTGEAFVVSVSHAEPLCIGLNCALGAIEMRPFIEAIGKCTTSYVICYPNAGLPNTFGGYDETPEVTAKHIKDFALDGLVNIVGGCCGTTPAHIREIAEAVKNCKPRIPPTSVFDGYMLLSGLEPFRIGPYTN-FVNIGERCNVAGSRRFAKLIMSDNYEEALSVAKAQVEMGAQILDINVDDGMLDGPTAMARFCNYIASEPDIAKVPLCIDSSNFNVIEAGLKCCQGKCIVNSISLKEGEEDFLAKAKKIKQFGAAVVIMAFDEVGQATDTETKVSVCTRAYNLLVEKLNFNPNDIIFDPNILTIGTGMEEHDKYAINFIEATKSIKESLKGARVSGGLSNLSFSFRGMEAIREAMHGVFLYHAIKAGMDMGIVNAGNLPVYDDIDKELLTLCEDLIWNRDPDGTEKLLKYAQTKAKGGK-KVIQT-DEWRNGSVEERLEYALIKGIEKFVIEDTEEARANKEKYSRPLHIIEGPLMNGMKVVGELFGAGKMFLPQVIKSARVMKKSVGHLIPFMEKEREAMRAISGTLEEDNPYQGTIVLATVKGDVHDIGKNIVGVVLGCNNFRVIDLGVMTPCDKILRAAIENKADIIGLSGLITPSLDEMIFVAKEMERLGIRTPLLIGGATTSRTHTAVKIAPRYNAPVIHCLDASKSVVVCSQLLDENVRDDFLEEITEEYEDIRQDHYESLRERRYLTLEQARNKGLHIDW-LSHPKPVRPKLIGTEVYSNYDLEKLRHYIDWKPFFDVWQLRGKYPNRAFPKIFNDKTVGEEAKRLYEDAQNMLNMVISEKKFEARGVVGIWPAHSVQDDILLY-ADEGNMSSTEAIATFYGLRQQAEKDSASTDP-YYCLSDFIAPQHSGVKDYLGVFAV-ACFGVEELSKVYEKQGDDYSSIMAKALGDRLVEAFAEELHERVRKDLWGYCSEEQLNVSDLRRIRYEGIRPAPGYPSQPDHIEKVTMWKLADVERTTGIKL-TESLAMSPASSVSGLMFSSPMSKYFAVGKISKDQVEDYACRKNMPVCEVEKWLGPILSYDPED 1253
BLAST of Methionine synthase vs. Ensembl Xenopus
Match: smap2 (small ArfGAP2 [Source:Xenbase;Acc:XB-GENE-5817085]) HSP 1 Score: 1617.82 bits (4188), Expect = 0.000e+0 Identity = 805/1259 (63.94%), Postives = 994/1259 (78.95%), Query Frame = 3
Query: 33 KNIKSVLFSTLRERIMILDGAMGTMIQTYKLEENDFRGEIFKDHPKLLRGNNDLLSLTKPDIVFNIHKEFLDSGADIIETNTFSGTAIAQADYGLEHMVYKLNYESAILARKACDLVSSKSGISRFVAGAIGPTNRTLSISPSVEKPEYRNITFDQLVTAYKEQAHALLDGGVDILLIETIFDTANAKAAVFALFEVFEEAGYEVPVFISGTIVDKSGRNLSGQTTEAFLTSISHIKPICIGLNCALGASDMRPFIETISANTTSFVICYPNAGLPNTFGAYDEKPEYTGEILSQFAKDGLINIVGGCCGTTPAHIAAIKKAVRGYSPRIPPTTLFEDCLVLSGLERFIINPRTTLFVNIGERCNVAGSRRFLRLIKTDKYEEALSIAKEQVENGAQVIDLNMDEGMLEGKLAMTKFINLISSEPDISKVPLCIDSSNFAVIEAGLKCTQGKCIVNSISLKEGELDFYRKLKIIKKFGAAVVIMAFDEQGQAADYDRKIAICCRIYDLLVNKMDFNPNDIIFDLNILTIGTGMEEHNGYGMDFIRATEFVKKNLPHAKVSGGVSNISFSFRGKEVVREAMHSVFLFHAIKAGMDMGIVNAGCLPVYDDIEPRLLELCEDILWNKRQDATDRLLEYAENLLKSDDVGILKTEDAWRSLSVSERLEHSLVKGIDKYIIEDTEEAR---KCHVRPLHVIEGPLMRGMSTVGDLFGAGKMFLPQVIKSARVMKRAVGYLIPFMEEEKRLAMEVSGIYSNEPQYVGTMVIATVKGDVHDIGKNIVGVVMGCNNYRVIDLGVMCPSEKILQCALEEKADVIGLSGLITPSLEEMMHVAREMERLGMRTPLLIGGATTSRQHTAVKIAPKYSGPTVHVLDASKSVVVTNSLLDDTXXXXXXXXXXXXXXXXXXXXXXSLAERIYLSIDEARKRKLQLNWSIDHFQSHRPNFLGSKIVENIDINILLPYIDWKPFFDVWQLRGKYPNRGYPKIFNDKDVGKEAQILFSDAQKVLFEIIQYKLLHVNGVIGFYPAHSEGDDILLYDPDSFNVNRKNHLTTLFGLRQQEERE----DPNYLCISDFIAPIESGCDDYVGMFAVTAGIGADSLAQKFQDQGDDYNSLMVKALADRLAEASAEYLHHIVRTTLWGYSPNENLTPEDYIKVMYDGIRPAPGYPTQPDHSEQATVWDLLKPER-IGINLHKDSLGMSPAASVSGLYFSHPKSKYFSVGKISKDQVYDYAKRKQISIGESEKRLQSILSYETDE 3785
+N++ L S LRERIM+LDG MGTMIQ + L+E FRG+ F DH K L+GNNDLLS+T+ +I++ IHKE+L GADI+ETNTFS T+IAQADYGLEH+ Y+LN SA +AR+A D V++++G+ R+VAGA+GPTN+TLS+SPSVE+P+YRN+TFD+LV AY EQA LLDGGVDILL+ETIFDTANAKAA+FA+ ++FEE P+FISGTIVDKSGR LSGQT EAF+ S+SH +P+CIGLNCALGA +MRPFIE I TTS+VICYPNAGLPNTFG YDE PE T + + FA DGL+NIVGGCCGTTPAHI I +AV+ PRIPPT++F+ ++LSGLE F I P T FVNIGERCNVAGSRRF +LI +D YEEALS+AK QVE GAQ++D+N+D+GML+G AM +F N I+SEPDI+KVPLCIDSSNF VIEAGLKC QGKCIVNSISLKEGE DF K K IK+FGAAVVIMAFDE GQA D + K+++C R Y+LLV K++FNPNDIIFD NILTIGTGMEEH+ Y ++FI AT+ +K++L A+VSGG+SN+SFSFRG E +REAMH VFL+HAIKAGMDMGIVNAG LPVYDDI+ LL LCED++WN+ D T++LL+YA+ K +++T D WR+ SV ERLE++L+KGI+K++IEDTEEAR + + RPLH+IEGPLM GM VG+LFGAGKMFLPQVIKSARVMK++VG+LIPFME+E+ +SG + Y GT+V+ATVKGDVHDIGKNIVGVV+GCNN+RVIDLGVM P +KIL+ A+E KAD+IGLSGLITPSL+EM+ VA+EMERLG+RTPLLIGGATTSR HTAVKIAP+Y+ P +H LDASKSVVV + LLD+ +F E I EEYE+IR++HYESL ER YL++++AR + L ++W + H + RP +G+++ N D+ L YIDWKPFFDVWQLRGKYPNR +PKIFNDK VG+EA+ L+ DAQ +L +I K GV+G +PAHS DDILLY D N++ + T +GLRQQ E++ DP Y C+SDFIAP SG DY+G+FAV A G + L++ ++ QGDDY+S+M KAL DRL EA AE LH VR LWGY E L D ++ Y+GIRPAPGYP+QPDH E+ T+W L ER GI L +SL MSPA+SVSGL FS P SKYF+VGKISKDQV DYA RK + + E EK L ILSY+ ++
Sbjct: 19 RNLQEELDSVLRERIMVLDGGMGTMIQQHTLQEESFRGQEFIDHAKPLKGNNDLLSITQSEIIYKIHKEYLTCGADIVETNTFSSTSIAQADYGLEHLAYRLNKVSAEVARRAADDVTAETGMKRYVAGAMGPTNKTLSVSPSVERPDYRNVTFDELVDAYAEQARGLLDGGVDILLVETIFDTANAKAALFAIQKLFEEDYEPRPIFISGTIVDKSGRTLSGQTGEAFVVSVSHAEPLCIGLNCALGAIEMRPFIEAIGKCTTSYVICYPNAGLPNTFGGYDETPEVTAKHIKDFALDGLVNIVGGCCGTTPAHIREIAEAVKNCKPRIPPTSVFDGYMLLSGLEPFRIGPYTN-FVNIGERCNVAGSRRFAKLIMSDNYEEALSVAKAQVEMGAQILDINVDDGMLDGPTAMARFCNYIASEPDIAKVPLCIDSSNFNVIEAGLKCCQGKCIVNSISLKEGEEDFLAKAKKIKQFGAAVVIMAFDEVGQATDTETKVSVCTRAYNLLVEKLNFNPNDIIFDPNILTIGTGMEEHDKYAINFIEATKSIKESLKGARVSGGLSNLSFSFRGMEAIREAMHGVFLYHAIKAGMDMGIVNAGNLPVYDDIDKELLTLCEDLIWNRDPDGTEKLLKYAQTKAKGGK-KVIQT-DEWRNGSVEERLEYALIKGIEKFVIEDTEEARANKEKYSRPLHIIEGPLMNGMKVVGELFGAGKMFLPQVIKSARVMKKSVGHLIPFMEKEREAMRAISGTLEEDNPYQGTIVLATVKGDVHDIGKNIVGVVLGCNNFRVIDLGVMTPCDKILRAAIENKADIIGLSGLITPSLDEMIFVAKEMERLGIRTPLLIGGATTSRTHTAVKIAPRYNAPVIHCLDASKSVVVCSQLLDENVRDDFLEEITEEYEDIRQDHYESLRERRYLTLEQARNKGLHIDW-LSHPKPVRPKLIGTEVYSNYDLEKLRHYIDWKPFFDVWQLRGKYPNRAFPKIFNDKTVGEEAKRLYEDAQNMLNMVISEKKFEARGVVGIWPAHSVQDDILLY-ADEGNMSSTEAIATFYGLRQQAEKDSASTDP-YYCLSDFIAPQHSGVKDYLGVFAV-ACFGVEELSKVYEKQGDDYSSIMAKALGDRLVEAFAEELHERVRKDLWGYCSEEQLNVSDLRRIRYEGIRPAPGYPSQPDHIEKVTMWKLADVERTTGIKL-TESLAMSPASSVSGLMFSSPMSKYFAVGKISKDQVEDYACRKNMPVCEVEKWLGPILSYDPED 1269
BLAST of Methionine synthase vs. Ensembl Xenopus
Match: smap2 (small ArfGAP2 [Source:Xenbase;Acc:XB-GENE-5817085]) HSP 1 Score: 1617.44 bits (4187), Expect = 0.000e+0 Identity = 805/1260 (63.89%), Postives = 995/1260 (78.97%), Query Frame = 3
Query: 30 RKNIKSVLFSTLRERIMILDGAMGTMIQTYKLEENDFRGEIFKDHPKLLRGNNDLLSLTKPDIVFNIHKEFLDSGADIIETNTFSGTAIAQADYGLEHMVYKLNYESAILARKACDLVSSKSGISRFVAGAIGPTNRTLSISPSVEKPEYRNITFDQLVTAYKEQAHALLDGGVDILLIETIFDTANAKAAVFALFEVFEEAGYEVPVFISGTIVDKSGRNLSGQTTEAFLTSISHIKPICIGLNCALGASDMRPFIETISANTTSFVICYPNAGLPNTFGAYDEKPEYTGEILSQFAKDGLINIVGGCCGTTPAHIAAIKKAVRGYSPRIPPTTLFEDCLVLSGLERFIINPRTTLFVNIGERCNVAGSRRFLRLIKTDKYEEALSIAKEQVENGAQVIDLNMDEGMLEGKLAMTKFINLISSEPDISKVPLCIDSSNFAVIEAGLKCTQGKCIVNSISLKEGELDFYRKLKIIKKFGAAVVIMAFDEQGQAADYDRKIAICCRIYDLLVNKMDFNPNDIIFDLNILTIGTGMEEHNGYGMDFIRATEFVKKNLPHAKVSGGVSNISFSFRGKEVVREAMHSVFLFHAIKAGMDMGIVNAGCLPVYDDIEPRLLELCEDILWNKRQDATDRLLEYAENLLKSDDVGILKTEDAWRSLSVSERLEHSLVKGIDKYIIEDTEEAR---KCHVRPLHVIEGPLMRGMSTVGDLFGAGKMFLPQVIKSARVMKRAVGYLIPFMEEEKRLAMEVSGIYSNEPQYVGTMVIATVKGDVHDIGKNIVGVVMGCNNYRVIDLGVMCPSEKILQCALEEKADVIGLSGLITPSLEEMMHVAREMERLGMRTPLLIGGATTSRQHTAVKIAPKYSGPTVHVLDASKSVVVTNSLLDDTXXXXXXXXXXXXXXXXXXXXXXSLAERIYLSIDEARKRKLQLNWSIDHFQSHRPNFLGSKIVENIDINILLPYIDWKPFFDVWQLRGKYPNRGYPKIFNDKDVGKEAQILFSDAQKVLFEIIQYKLLHVNGVIGFYPAHSEGDDILLYDPDSFNVNRKNHLTTLFGLRQQEERE----DPNYLCISDFIAPIESGCDDYVGMFAVTAGIGADSLAQKFQDQGDDYNSLMVKALADRLAEASAEYLHHIVRTTLWGYSPNENLTPEDYIKVMYDGIRPAPGYPTQPDHSEQATVWDLLKPER-IGINLHKDSLGMSPAASVSGLYFSHPKSKYFSVGKISKDQVYDYAKRKQISIGESEKRLQSILSYETDE 3785
++N++ L S LRERIM+LDG MGTMIQ + L+E FRG+ F DH K L+GNNDLLS+T+ +I++ IHKE+L GADI+ETNTFS T+IAQADYGLEH+ Y+LN SA +AR+A D V++++G+ R+VAGA+GPTN+TLS+SPSVE+P+YRN+TFD+LV AY EQA LLDGGVDILL+ETIFDTANAKAA+FA+ ++FEE P+FISGTIVDKSGR LSGQT EAF+ S+SH +P+CIGLNCALGA +MRPFIE I TTS+VICYPNAGLPNTFG YDE PE T + + FA DGL+NIVGGCCGTTPAHI I +AV+ PRIPPT++F+ ++LSGLE F I P T FVNIGERCNVAGSRRF +LI +D YEEALS+AK QVE GAQ++D+N+D+GML+G AM +F N I+SEPDI+KVPLCIDSSNF VIEAGLKC QGKCIVNSISLKEGE DF K K IK+FGAAVVIMAFDE GQA D + K+++C R Y+LLV K++FNPNDIIFD NILTIGTGMEEH+ Y ++FI AT+ +K++L A+VSGG+SN+SFSFRG E +REAMH VFL+HAIKAGMDMGIVNAG LPVYDDI+ LL LCED++WN+ D T++LL+YA+ K +++T D WR+ SV ERLE++L+KGI+K++IEDTEEAR + + RPLH+IEGPLM GM VG+LFGAGKMFLPQVIKSARVMK++VG+LIPFME+E+ +SG + Y GT+V+ATVKGDVHDIGKNIVGVV+GCNN+RVIDLGVM P +KIL+ A+E KAD+IGLSGLITPSL+EM+ VA+EMERLG+RTPLLIGGATTSR HTAVKIAP+Y+ P +H LDASKSVVV + LLD+ +F E I EEYE+IR++HYESL ER YL++++AR + L ++W + H + RP +G+++ N D+ L YIDWKPFFDVWQLRGKYPNR +PKIFNDK VG+EA+ L+ DAQ +L +I K GV+G +PAHS DDILLY D N++ + T +GLRQQ E++ DP Y C+SDFIAP SG DY+G+FAV A G + L++ ++ QGDDY+S+M KAL DRL EA AE LH VR LWGY E L D ++ Y+GIRPAPGYP+QPDH E+ T+W L ER GI L +SL MSPA+SVSGL FS P SKYF+VGKISKDQV DYA RK + + E EK L ILSY+ ++
Sbjct: 9 KRNLQEELDSVLRERIMVLDGGMGTMIQQHTLQEESFRGQEFIDHAKPLKGNNDLLSITQSEIIYKIHKEYLTCGADIVETNTFSSTSIAQADYGLEHLAYRLNKVSAEVARRAADDVTAETGMKRYVAGAMGPTNKTLSVSPSVERPDYRNVTFDELVDAYAEQARGLLDGGVDILLVETIFDTANAKAALFAIQKLFEEDYEPRPIFISGTIVDKSGRTLSGQTGEAFVVSVSHAEPLCIGLNCALGAIEMRPFIEAIGKCTTSYVICYPNAGLPNTFGGYDETPEVTAKHIKDFALDGLVNIVGGCCGTTPAHIREIAEAVKNCKPRIPPTSVFDGYMLLSGLEPFRIGPYTN-FVNIGERCNVAGSRRFAKLIMSDNYEEALSVAKAQVEMGAQILDINVDDGMLDGPTAMARFCNYIASEPDIAKVPLCIDSSNFNVIEAGLKCCQGKCIVNSISLKEGEEDFLAKAKKIKQFGAAVVIMAFDEVGQATDTETKVSVCTRAYNLLVEKLNFNPNDIIFDPNILTIGTGMEEHDKYAINFIEATKSIKESLKGARVSGGLSNLSFSFRGMEAIREAMHGVFLYHAIKAGMDMGIVNAGNLPVYDDIDKELLTLCEDLIWNRDPDGTEKLLKYAQTKAKGGK-KVIQT-DEWRNGSVEERLEYALIKGIEKFVIEDTEEARANKEKYSRPLHIIEGPLMNGMKVVGELFGAGKMFLPQVIKSARVMKKSVGHLIPFMEKEREAMRAISGTLEEDNPYQGTIVLATVKGDVHDIGKNIVGVVLGCNNFRVIDLGVMTPCDKILRAAIENKADIIGLSGLITPSLDEMIFVAKEMERLGIRTPLLIGGATTSRTHTAVKIAPRYNAPVIHCLDASKSVVVCSQLLDENVRDDFLEEITEEYEDIRQDHYESLRERRYLTLEQARNKGLHIDW-LSHPKPVRPKLIGTEVYSNYDLEKLRHYIDWKPFFDVWQLRGKYPNRAFPKIFNDKTVGEEAKRLYEDAQNMLNMVISEKKFEARGVVGIWPAHSVQDDILLY-ADEGNMSSTEAIATFYGLRQQAEKDSASTDP-YYCLSDFIAPQHSGVKDYLGVFAV-ACFGVEELSKVYEKQGDDYSSIMAKALGDRLVEAFAEELHERVRKDLWGYCSEEQLNVSDLRRIRYEGIRPAPGYPSQPDHIEKVTMWKLADVERTTGIKL-TESLAMSPASSVSGLMFSSPMSKYFAVGKISKDQVEDYACRKNMPVCEVEKWLGPILSYDPED 1260
BLAST of Methionine synthase vs. Ensembl Xenopus
Match: smap2 (small ArfGAP2 [Source:Xenbase;Acc:XB-GENE-5817085]) HSP 1 Score: 1552.34 bits (4018), Expect = 0.000e+0 Identity = 785/1271 (61.76%), Postives = 975/1271 (76.71%), Query Frame = 3
Query: 3 NLYVFR*--NMRKNIKSVLFSTLRERIMILDGAMGTMIQTYKLEENDFRGEIFKDHPKLLRGNNDLLSLTKPDIVFNIHKEFLDSGADIIETNTFSGTAIAQADYGLEHMVYKLNYESAILARKACDLVSSKSGISRFVAGAIGPTNRTLSISPSVEKPEYRNITFDQLVTAYKEQAHALLDGGVDILLIETIFDTANAKAAVFALFEVFEEAGYEVPVFISGTIVDKSGRNLSGQTTEAFLTSISHIKPICIGLNCALGASDMRPFIETISANTTSFVICYPNAGLPNTFGAYDEKPEYTGEILSQFAKDGLINIVGGCCGTTPAHIAAIKKAVRGYSPRIPPTTLFEDCLVLSGLERFIINPRTTLFVNIGERCNVAGSRRFLRLIKTDKYEEALSIAKEQVENGAQVIDLNMDEGMLEGKLAMTKFINLISSEPDISKVPLCIDSSNFAVIEAGLKCTQGKCIVNSISLKEGELDFYRKLKIIKKFGAAVVIMAFDEQGQAADYDRKIAICCRIYDLLVNKMDFNPNDIIFDLNILTIGTGMEEHNGYGMDFIRATEFVKKNLPHAKVSGGVSNISFSFRGKEVVREAMHSVFLFHAIKAGMDMGIVNAGCLPVYDDIEPRLLELCEDILWNKRQDATDRLLEYAENLLKSDDVGILKTEDAWRSLSVSERLEHSLVKGIDKYIIEDTEEAR---KCHVRPLHVIEGPLMRGMSTVGDLFGAGKMFLPQVIKSARVMKRAVGYLIPFMEEEKRLAMEVSGIYSNEPQYVGTMVIATVKGDVHDIGKNIVGVVMGCNNYRVIDLGVMCPSEKILQCALEEKADVIGLSGLITPSLEEMMHVAREMERLGMRTPLLIGGATTSRQHTAVKIAPKYSGPTVHVLDASKSVVVTNSLLDDTXXXXXXXXXXXXXXXXXXXXXXSLAERIYLSIDEARKRKLQLNWSIDHFQSHRPNFLGSKIVENIDINILLPYIDWKPFFDVWQLRGKYPNRGYPKIFNDKDVGKEAQILFSDAQKVLFEIIQYKLLHVNGVIGFYPAHSEGDDILLYDPDSFNVNRKNHLTTLFGLRQQEERE----DPNYLCISDFIAPIESGCDDYVGMFAVTAGIGADSLAQKFQDQGDDYNSLMVKALADRLAEASAEYLHHIVRTTLWGYSPNENLTPEDYIKVMYDGIRPAPGYPTQPDHSEQATVWDLLKPER-IGINLHKDSLGMSPAASVSGLYFSHPKSKYFSVGKISKDQVYDYAKRKQISIGESEKRLQSILSYETDE 3785
N++ F +++N++ L S LRERIM+LDG MGTMIQ + L+E FRG+ F DH K L+GNNDLLS+T+ +I++ IHKE+L GADI+ETNTFS T+IAQADYGLEH+ Y+LN SA +AR+A D V++++G+ R+VAGA+GPTN+TLS+SPSVE+P+YRN+TFD+LV AY EQA LLDGGVDILL+ETIFDTANAKAA+FA+ ++FEE P+FISGTIVDKSGR LSGQT EAF+ S+SH +P+CIGLNCALGA +MRPFIE I TTS+VICYPNAGLPNTFG YDE PE T + + FA DGL+NIVGGCCGTTPAHI I +AV+ PRIPPT++F+ ++LSGLE F I P T FVNIGERCNVAGSRRF +LI +D YEEALS+AK QVE GAQ++D+N+D+GML+G AM +F N I+SEPDI+KVPLCIDSSNF VIEAGLKC QGKCIVNSISLKEGE DF K K IK+FGAAVVIMAFDE GQA D + K+++C R Y+LLV K++FNPNDIIFD NILTIGTGMEEH+ Y ++FI AT+ +K++L A+VSGG+SN+SFSFRG E +REAMH VFL+HAIKAGMDMGIVNAG LPVYDDI+ LL LCED++WN+ D T++LL+YA+ K +++T D WR+ SV ERLE++L+KGI+K++IEDTEEAR + + RPLH+IEGPLM GM VG+LFGAGKMFLPQVIKSARVMK++VG+LIPFME+E+ +SG + V D I + GC VIDLGVM P +KIL+ A+E KAD+IGLSGLITPSL+EM+ VA+EMERLG+RTPLLIGGATTSR HTAVKIAP+Y+ P +H LDASKSVVV + LLD+ +F E I EEYE+IR++HYESL ER YL++++AR + L ++W + H + RP +G+++ N D+ L YIDWKPFFDVWQLRGKYPNR +PKIFNDK VG+EA+ L+ DAQ +L +I K GV+G +PAHS DDILLY D N++ + T +GLRQQ E++ DP Y C+SDFIAP SG DY+G+FAV A G + L++ ++ QGDDY+S+M KAL DRL EA AE LH VR LWGY E L D ++ Y+GIRPAPGYP+QPDH E+ T+W L ER GI L +SL MSPA+SVSGL FS P SKYF+VGKISKDQV DYA RK + + E EK L ILSY+ ++
Sbjct: 17 NMFAFSQIETLKRNLQEELDSVLRERIMVLDGGMGTMIQQHTLQEESFRGQEFIDHAKPLKGNNDLLSITQSEIIYKIHKEYLTCGADIVETNTFSSTSIAQADYGLEHLAYRLNKVSAEVARRAADDVTAETGMKRYVAGAMGPTNKTLSVSPSVERPDYRNVTFDELVDAYAEQARGLLDGGVDILLVETIFDTANAKAALFAIQKLFEEDYEPRPIFISGTIVDKSGRTLSGQTGEAFVVSVSHAEPLCIGLNCALGAIEMRPFIEAIGKCTTSYVICYPNAGLPNTFGGYDETPEVTAKHIKDFALDGLVNIVGGCCGTTPAHIREIAEAVKNCKPRIPPTSVFDGYMLLSGLEPFRIGPYTN-FVNIGERCNVAGSRRFAKLIMSDNYEEALSVAKAQVEMGAQILDINVDDGMLDGPTAMARFCNYIASEPDIAKVPLCIDSSNFNVIEAGLKCCQGKCIVNSISLKEGEEDFLAKAKKIKQFGAAVVIMAFDEVGQATDTETKVSVCTRAYNLLVEKLNFNPNDIIFDPNILTIGTGMEEHDKYAINFIEATKSIKESLKGARVSGGLSNLSFSFRGMEAIREAMHGVFLYHAIKAGMDMGIVNAGNLPVYDDIDKELLTLCEDLIWNRDPDGTEKLLKYAQTKAKGGK-KVIQT-DEWRNGSVEERLEYALIKGIEKFVIEDTEEARANKEKYSRPLHIIEGPLMNGMKVVGELFGAGKMFLPQVIKSARVMKKSVGHLIPFMEKEREAMRAISGTLEED-----------VSPDFCIISAFCTNIFFGC---LVIDLGVMTPCDKILRAAIENKADIIGLSGLITPSLDEMIFVAKEMERLGIRTPLLIGGATTSRTHTAVKIAPRYNAPVIHCLDASKSVVVCSQLLDENVRDDFLEEITEEYEDIRQDHYESLRERRYLTLEQARNKGLHIDW-LSHPKPVRPKLIGTEVYSNYDLEKLRHYIDWKPFFDVWQLRGKYPNRAFPKIFNDKTVGEEAKRLYEDAQNMLNMVISEKKFEARGVVGIWPAHSVQDDILLY-ADEGNMSSTEAIATFYGLRQQAEKDSASTDP-YYCLSDFIAPQHSGVKDYLGVFAV-ACFGVEELSKVYEKQGDDYSSIMAKALGDRLVEAFAEELHERVRKDLWGYCSEEQLNVSDLRRIRYEGIRPAPGYPSQPDHIEKVTMWKLADVERTTGIKL-TESLAMSPASSVSGLMFSSPMSKYFAVGKISKDQVEDYACRKNMPVCEVEKWLGPILSYDPED 1265
BLAST of Methionine synthase vs. Ensembl Mouse
Match: Mtr (5-methyltetrahydrofolate-homocysteine methyltransferase [Source:MGI Symbol;Acc:MGI:894292]) HSP 1 Score: 1582.77 bits (4097), Expect = 0.000e+0 Identity = 795/1261 (63.05%), Postives = 989/1261 (78.43%), Query Frame = 3
Query: 27 MRKNIKSVLFSTLRERIMILDGAMGTMIQTYKLEENDFRGEIFKDHPKLLRGNNDLLSLTKPDIVFNIHKEFLDSGADIIETNTFSGTAIAQADYGLEHMVYKLNYESAILARKACDLVSSKSGISRFVAGAIGPTNRTLSISPSVEKPEYRNITFDQLVTAYKEQAHALLDGGVDILLIETIFDTANAKAAVFALFEVFEEA-GYEVPVFISGTIVDKSGRNLSGQTTEAFLTSISHIKPICIGLNCALGASDMRPFIETISANTTSFVICYPNAGLPNTFGAYDEKPEYTGEILSQFAKDGLINIVGGCCGTTPAHIAAIKKAVRGYSPRIPPTTLFEDCLVLSGLERFIINPRTTLFVNIGERCNVAGSRRFLRLIKTDKYEEALSIAKEQVENGAQVIDLNMDEGMLEGKLAMTKFINLISSEPDISKVPLCIDSSNFAVIEAGLKCTQGKCIVNSISLKEGELDFYRKLKIIKKFGAAVVIMAFDEQGQAADYDRKIAICCRIYDLLVNKMDFNPNDIIFDLNILTIGTGMEEHNGYGMDFIRATEFVKKNLPHAKVSGGVSNISFSFRGKEVVREAMHSVFLFHAIKAGMDMGIVNAGCLPVYDDIEPRLLELCEDILWNKRQDATDRLLEYAENLLKSDDVGILKTEDAWRSLSVSERLEHSLVKGIDKYIIEDTEEAR---KCHVRPLHVIEGPLMRGMSTVGDLFGAGKMFLPQVIKSARVMKRAVGYLIPFMEEEKRLAMEVSGIYSNEPQYVGTMVIATVKGDVHDIGKNIVGVVMGCNNYRVIDLGVMCPSEKILQCALEEKADVIGLSGLITPSLEEMMHVAREMERLGMRTPLLIGGATTSRQHTAVKIAPKYSGPTVHVLDASKSVVVTNSLLDDTXXXXXXXXXXXXXXXXXXXXXXSLAERIYLSIDEARKRKLQLNWSIDHFQSHRPNFLGSKIVENIDINILLPYIDWKPFFDVWQLRGKYPNRGYPKIFNDKDVGKEAQILFSDAQKVLFEIIQYKLLHVNGVIGFYPAHSEGDDILLYDPDSFNVNRKNHLTTLFGLRQQEERE----DPNYLCISDFIAPIESGCDDYVGMFAVTAGIGADSLAQKFQDQGDDYNSLMVKALADRLAEASAEYLHHIVRTTLWGYSPNENLTPEDYIKVMYDGIRPAPGYPTQPDHSEQATVWDLLKPER-IGINLHKDSLGMSPAASVSGLYFSHPKSKYFSVGKISKDQVYDYAKRKQISIGESEKRLQSILSYETD 3782
M+K ++ + + LR+RIM+LDG MGTMIQ YKL E F+G+ FKDH + L+GNND+LS+T+PDI++ IHKE+L +GADIIETNTFS T+IAQADYGLEH+ Y++N SA +ARKA + ++ ++G+ RFVAGA+GPTN+TLS+SPSVE+P+YRNITFD+LV AY+EQA LLDG VDILLIETIFDTANAKAA+FA+ +FEE P+FISGTIVDKSGR LSGQT EAF+TS+SH P+CIGLNC+LGA++MRPFIETI TT++V+CYPNAGLPNTFG YDE P L FA DGL+NIVGGCCG+TP HI I +AV+ PR+PP ++FE ++LSGLE F I P T FVNIGERCNVAGSR+F +LI YEEALSIAK QVE GAQV+D+NMD+GML+G AMT+F N I+SEPDI+KVPLCIDSSNFAVIEAGLKC QGKCIVNSISLKEGE DF K + IKKFGAAVV+MAFDE+GQA + D K+ +C R Y LLV+K+ FNPNDIIFD NILTIGTGMEEHN Y ++FI AT +K+ LP ++SGG+SN+SFSFRG E +REAMH VFL+HAIK GMDMGIVNAG LPVYD I LL+LCED++WNK +AT++LL YA+ + +++T D WR+ S+ ERLE++LVKGI+K+I+EDTEEAR + + RPL++IEGPLM GM VGDLFGAGKMFLPQVIKSARVMK+AVG+LIPFME+E+ A ++G E Y GT+V+ATVKGDVHDIGKNIVGVV+ CNN+RVIDLGVM P +KILQ AL+ KAD+IGLSGLITPSL+EM+ VA+EMERL ++ PLLIGGATTSR HTAVKIAP+YS P +HVLDASKSVVV + LLD+ ++ E I EEYE+IR++HYESL ER Y+ + +ARK ++W + +P F+G+++ E+ ++ L+ YIDWKPFFDVWQLRGKYPNRG+PKIFNDK VG+EA+ +++DAQ +L +I K L GV+GF+PA S DDI LY + + T +GLRQQ E++ DP Y C+SDFIAP+ SG DY+G+FAV A G + L++ ++D GDDY+S+MVKAL DRLAEA AE LH VR LW YS +E L D ++ Y+GIRPAPGYP+QPDH+E+ T+W L E+ GI L +SL M+PA++VSGLYFS+ K+KYF+VGKISKDQ DYA RK + + E EK L IL Y+TD
Sbjct: 1 MKKTLQDEIEAILRKRIMVLDGGMGTMIQRYKLSEEHFQGQEFKDHSRPLKGNNDILSITQPDIIYQIHKEYLLAGADIIETNTFSSTSIAQADYGLEHLAYRMNKCSADVARKAAEEITLQTGVKRFVAGALGPTNKTLSVSPSVERPDYRNITFDELVDAYQEQAKGLLDGRVDILLIETIFDTANAKAALFAIQNLFEENYAPPRPIFISGTIVDKSGRTLSGQTGEAFVTSVSHSDPLCIGLNCSLGAAEMRPFIETIGKCTTAYVLCYPNAGLPNTFGDYDETPSTMATHLKDFAVDGLVNIVGGCCGSTPDHIREIAEAVKKCKPRVPPASVFEGHMLLSGLEPFRIGPYTN-FVNIGERCNVAGSRKFAKLIMAGNYEEALSIAKAQVEMGAQVLDINMDDGMLDGPSAMTRFCNSIASEPDIAKVPLCIDSSNFAVIEAGLKCCQGKCIVNSISLKEGEGDFLEKARKIKKFGAAVVVMAFDEEGQATETDVKVNVCTRAYHLLVDKVGFNPNDIIFDPNILTIGTGMEEHNLYAINFIHATRVIKETLPGVRISGGLSNLSFSFRGMEAIREAMHGVFLYHAIKFGMDMGIVNAGNLPVYDAIHKDLLQLCEDLIWNKDSEATEKLLRYAQT-HGTGGKKVIQT-DEWRNGSIEERLEYALVKGIEKHIVEDTEEARLNGEKYPRPLNIIEGPLMNGMKVVGDLFGAGKMFLPQVIKSARVMKKAVGHLIPFMEKEREEARLINGSVEEEDPYQGTIVLATVKGDVHDIGKNIVGVVLACNNFRVIDLGVMTPCDKILQAALDHKADIIGLSGLITPSLDEMIFVAKEMERLAIKIPLLIGGATTSRTHTAVKIAPRYSAPVIHVLDASKSVVVCSQLLDENLRDDYFEEILEEYEDIRQDHYESLKERKYVPLSQARKHGFHIDW-LSEPHPVKPTFIGTQVFEDYNLQKLVDYIDWKPFFDVWQLRGKYPNRGFPKIFNDKAVGEEARKVYNDAQNMLNILISQKKLQARGVVGFWPAQSVQDDIHLY-AEGVVPQAAEPIATFYGLRQQAEKDSSSTDP-YHCLSDFIAPLHSGVCDYLGLFAV-ACFGVEELSKTYEDDGDDYSSIMVKALGDRLAEAFAEELHERVRRELWAYSRSEQLGVPDLRRLRYEGIRPAPGYPSQPDHTEKLTMWRLASIEQATGIRL-TESLAMAPASAVSGLYFSNVKAKYFAVGKISKDQTEDYALRKNMPVAEVEKWLGPILGYDTD 1253
BLAST of Methionine synthase vs. Ensembl Mouse
Match: Mtr (5-methyltetrahydrofolate-homocysteine methyltransferase [Source:MGI Symbol;Acc:MGI:894292]) HSP 1 Score: 145.206 bits (365), Expect = 1.143e-38 Identity = 64/100 (64.00%), Postives = 84/100 (84.00%), Query Frame = 3
Query: 27 MRKNIKSVLFSTLRERIMILDGAMGTMIQTYKLEENDFRGEIFKDHPKLLRGNNDLLSLTKPDIVFNIHKEFLDSGADIIETNTFSGTAIAQADYGLEHM 326
M+K ++ + + LR+RIM+LDG MGTMIQ YKL E F+G+ FKDH + L+GNND+LS+T+PDI++ IHKE+L +GADIIETNTFS T+IAQADYGLEH+
Sbjct: 1 MKKTLQDEIEAILRKRIMVLDGGMGTMIQRYKLSEEHFQGQEFKDHSRPLKGNNDILSITQPDIIYQIHKEYLLAGADIIETNTFSSTSIAQADYGLEHL 100
BLAST of Methionine synthase vs. UniProt/SwissProt
Match: sp|Q4JIJ3|METH_BOVIN (Methionine synthase OS=Bos taurus OX=9913 GN=MTR PE=2 SV=1) HSP 1 Score: 1610.89 bits (4170), Expect = 0.000e+0 Identity = 808/1260 (64.13%), Postives = 994/1260 (78.89%), Query Frame = 3
Query: 27 MRKNIKSVLFSTLRERIMILDGAMGTMIQTYKLEENDFRGEIFKDHPKLLRGNNDLLSLTKPDIVFNIHKEFLDSGADIIETNTFSGTAIAQADYGLEHMVYKLNYESAILARKACDLVSSKSGISRFVAGAIGPTNRTLSISPSVEKPEYRNITFDQLVTAYKEQAHALLDGGVDILLIETIFDTANAKAAVFALFEVFEEAGYEVPVFISGTIVDKSGRNLSGQTTEAFLTSISHIKPICIGLNCALGASDMRPFIETISANTTSFVICYPNAGLPNTFGAYDEKPEYTGEILSQFAKDGLINIVGGCCGTTPAHIAAIKKAVRGYSPRIPPTTLFEDCLVLSGLERFIINPRTTLFVNIGERCNVAGSRRFLRLIKTDKYEEALSIAKEQVENGAQVIDLNMDEGMLEGKLAMTKFINLISSEPDISKVPLCIDSSNFAVIEAGLKCTQGKCIVNSISLKEGELDFYRKLKIIKKFGAAVVIMAFDEQGQAADYDRKIAICCRIYDLLVNKMDFNPNDIIFDLNILTIGTGMEEHNGYGMDFIRATEFVKKNLPHAKVSGGVSNISFSFRGKEVVREAMHSVFLFHAIKAGMDMGIVNAGCLPVYDDIEPRLLELCEDILWNKRQDATDRLLEYAENLLKSDDVGILKTEDAWRSLSVSERLEHSLVKGIDKYIIEDTEEAR---KCHVRPLHVIEGPLMRGMSTVGDLFGAGKMFLPQVIKSARVMKRAVGYLIPFMEEEKRLAMEVSGIYSNEPQYVGTMVIATVKGDVHDIGKNIVGVVMGCNNYRVIDLGVMCPSEKILQCALEEKADVIGLSGLITPSLEEMMHVAREMERLGMRTPLLIGGATTSRQHTAVKIAPKYSGPTVHVLDASKSVVVTNSLLDDTXXXXXXXXXXXXXXXXXXXXXXSLAERIYLSIDEARKRKLQLNWSIDHFQSHRPNFLGSKIVENIDINILLPYIDWKPFFDVWQLRGKYPNRGYPKIFNDKDVGKEAQILFSDAQKVLFEIIQYKLLHVNGVIGFYPAHSEGDDILLYDPDSFNVNRKNHLTTLFGLRQQEERE----DPNYLCISDFIAPIESGCDDYVGMFAVTAGIGADSLAQKFQDQGDDYNSLMVKALADRLAEASAEYLHHIVRTTLWGYSPNENLTPEDYIKVMYDGIRPAPGYPTQPDHSEQATVWDLLKPE-RIGINLHKDSLGMSPAASVSGLYFSHPKSKYFSVGKISKDQVYDYAKRKQISIGESEKRLQSILSYETD 3782
M+K ++ + + L+ERIM+LDG MGTMIQ +KL E DFRG+ FKDH + L+GNND+LS+T+P++++ IHKE+L +GADIIETNTFS T+IAQADYGLEH+ Y++N SA +ARKA + +S ++GI R+VAGA+GPTN+TLS+SPSVE+P+YRNITFD+LV AYKEQA LLDGGVDILLIETIFDTANAKAA+FA+ ++FEE PVFISGTIVDKSGR LSGQT EAF+ S+SH P+CIGLNCALGA++MRPFIETI TT++V+CYPNAGLPNTFG YDE P L FA DGL+NIVGGCCGTTP HI I +AV+ PR+PP T+FE ++LSGLE F I P T FVNIGERCNVAGSRRF +LI YEEALS+AK QVE GAQV+D+NMD+GML+G AMT+F N I+SEPDI+KVPLCIDSSNFAVIEAGLKC QGKCIVNSISLKEGE DF K + IKKFGAAVV+MAFDE+GQA + D KI +C R Y LL+ K+ FNPNDIIFD NILTIGTGMEEHN Y ++FI AT+ +K+ LP AKVSGG+SN+SFSFRG E +REAMH VFL+HAIK GMDMGIVNAG LPVYDDI LL+LCED++WN+ +AT++LL YA+ K +++T D WR+ + ERLE++LVKGI+KYIIEDTEEAR + + RPL++IEGPLM GM VGDLFGAGKMFLPQVIKSARVMK+AVG+LIPFME+E+ ++G +E Y GT+V+ATVKGDVHDIGKNIVGVV+GCNN+RVIDLGVM P +KIL+ AL+ KAD+IGLSGLITPSL+EM+ VA+EMERL ++ PLLIGGATTSR HTAVKIAP+YS P +HVLDASKSVVV + LLD+ E+ E I EEYE+IR++HYESL ER YL++ +AR+ ++W + +P FLG+++ E+ D+ L+ YIDWKPFFDVWQLRGKYPNRG+PKIF+DK VG+EA+ ++ DAQ +L +I K L GV+GF+PA S DDI LY + + T +GLRQQ E++ DP YLC+SDFIAP+ SG DY+G+FAV A G + L++ ++++ DDY+S+MVKAL DRLAEA AE LH R LWGY E L D ++ Y+GIRPAPGYP+QPDH+E+ TVW L E R GI L +SL M+PA++VSGLYFS+ KSKYF+VGKISKDQ+ DYA RK +S+ E EK L IL Y+TD
Sbjct: 14 MKKTLQDEIEAILQERIMVLDGGMGTMIQRHKLSEEDFRGQEFKDHARPLKGNNDILSITQPNVIYQIHKEYLLAGADIIETNTFSSTSIAQADYGLEHLAYRMNMCSAGVARKAAEDISLQTGIKRYVAGALGPTNKTLSVSPSVERPDYRNITFDELVEAYKEQAKGLLDGGVDILLIETIFDTANAKAALFAVQKLFEEEYVPRPVFISGTIVDKSGRTLSGQTGEAFVISVSHADPLCIGLNCALGAAEMRPFIETIGKCTTAYVLCYPNAGLPNTFGDYDETPHVMAMHLKDFAVDGLVNIVGGCCGTTPDHIREIAEAVKNCKPRVPPATVFEGHMLLSGLEPFRIGPYTN-FVNIGERCNVAGSRRFAKLIMAGNYEEALSVAKMQVEMGAQVLDINMDDGMLDGPSAMTRFCNFIASEPDIAKVPLCIDSSNFAVIEAGLKCCQGKCIVNSISLKEGEDDFLEKARKIKKFGAAVVVMAFDEEGQATETDPKIRVCTRAYHLLLKKLGFNPNDIIFDPNILTIGTGMEEHNLYAVNFINATKVIKETLPGAKVSGGLSNLSFSFRGMEAIREAMHGVFLYHAIKFGMDMGIVNAGSLPVYDDIHKELLQLCEDLIWNRDPEATEKLLHYAQTQGKGGK-KVIQT-DEWRNGPLEERLEYALVKGIEKYIIEDTEEARLNQEKYPRPLNIIEGPLMNGMKIVGDLFGAGKMFLPQVIKSARVMKKAVGHLIPFMEKEREETKVLTGKIEDEDPYQGTIVLATVKGDVHDIGKNIVGVVLGCNNFRVIDLGVMTPCDKILKAALDHKADIIGLSGLITPSLDEMIFVAKEMERLAIKIPLLIGGATTSRTHTAVKIAPRYSAPVIHVLDASKSVVVCSQLLDENLKDEYFEEILEEYEDIRQDHYESLKERRYLTLRQARENGFHIDW-LSEPPPVKPTFLGTRVFEDYDLQKLVDYIDWKPFFDVWQLRGKYPNRGFPKIFDDKTVGEEAKKVYDDAQNMLQALISQKKLQARGVVGFWPAQSIQDDIHLYAEGAVP-QASEPIATFYGLRQQAEKDSASSDP-YLCLSDFIAPLHSGIPDYLGLFAV-ACFGVEELSKAYEEECDDYSSIMVKALGDRLAEAFAEELHERARRELWGYCSGEQLAVADLRRLRYEGIRPAPGYPSQPDHTEKLTVWRLADVEQRTGIRL-TESLAMAPASAVSGLYFSNLKSKYFAVGKISKDQIEDYASRKNMSVAEVEKWLGPILGYDTD 1265
BLAST of Methionine synthase vs. UniProt/SwissProt
Match: sp|Q99707|METH_HUMAN (Methionine synthase OS=Homo sapiens OX=9606 GN=MTR PE=1 SV=2) HSP 1 Score: 1596.64 bits (4133), Expect = 0.000e+0 Identity = 800/1259 (63.54%), Postives = 987/1259 (78.40%), Query Frame = 3
Query: 27 MRKNIKSVLFSTLRERIMILDGAMGTMIQTYKLEENDFRGEIFKDHPKLLRGNNDLLSLTKPDIVFNIHKEFLDSGADIIETNTFSGTAIAQADYGLEHMVYKLNYESAILARKACDLVSSKSGISRFVAGAIGPTNRTLSISPSVEKPEYRNITFDQLVTAYKEQAHALLDGGVDILLIETIFDTANAKAAVFALFEVFEEAGYEVPVFISGTIVDKSGRNLSGQTTEAFLTSISHIKPICIGLNCALGASDMRPFIETISANTTSFVICYPNAGLPNTFGAYDEKPEYTGEILSQFAKDGLINIVGGCCGTTPAHIAAIKKAVRGYSPRIPPTTLFEDCLVLSGLERFIINPRTTLFVNIGERCNVAGSRRFLRLIKTDKYEEALSIAKEQVENGAQVIDLNMDEGMLEGKLAMTKFINLISSEPDISKVPLCIDSSNFAVIEAGLKCTQGKCIVNSISLKEGELDFYRKLKIIKKFGAAVVIMAFDEQGQAADYDRKIAICCRIYDLLVNKMDFNPNDIIFDLNILTIGTGMEEHNGYGMDFIRATEFVKKNLPHAKVSGGVSNISFSFRGKEVVREAMHSVFLFHAIKAGMDMGIVNAGCLPVYDDIEPRLLELCEDILWNKRQDATDRLLEYAENLLKSDDVGILKTEDAWRSLSVSERLEHSLVKGIDKYIIEDTEEAR---KCHVRPLHVIEGPLMRGMSTVGDLFGAGKMFLPQVIKSARVMKRAVGYLIPFMEEEKRLAMEVSGIYSNEPQYVGTMVIATVKGDVHDIGKNIVGVVMGCNNYRVIDLGVMCPSEKILQCALEEKADVIGLSGLITPSLEEMMHVAREMERLGMRTPLLIGGATTSRQHTAVKIAPKYSGPTVHVLDASKSVVVTNSLLDDTXXXXXXXXXXXXXXXXXXXXXXSLAERIYLSIDEARKRKLQLNWSIDHFQSHRPNFLGSKIVENIDINILLPYIDWKPFFDVWQLRGKYPNRGYPKIFNDKDVGKEAQILFSDAQKVLFEIIQYKLLHVNGVIGFYPAHSEGDDILLYDPDSFNVNRKNHLTTLFGLRQQEEREDPN---YLCISDFIAPIESGCDDYVGMFAVTAGIGADSLAQKFQDQGDDYNSLMVKALADRLAEASAEYLHHIVRTTLWGYSPNENLTPEDYIKVMYDGIRPAPGYPTQPDHSEQATVWDLLKPER-IGINLHKDSLGMSPAASVSGLYFSHPKSKYFSVGKISKDQVYDYAKRKQISIGESEKRLQSILSYETD 3782
++K ++ + + L++RIM+LDG MGTMIQ KL E FRG+ FKDH + L+GNND+LS+T+PD+++ IHKE+L +GADIIETNTFS T+IAQADYGLEH+ Y++N SA +ARKA + V+ ++GI RFVAGA+GPTN+TLS+SPSVE+P+YRNITFD+LV AY+EQA LLDGGVDILLIETIFDTANAKAA+FAL +FEE P+FISGTIVDKSGR LSGQT E F+ S+SH +P+CIGLNCALGA++MRPFIE I TT++V+CYPNAGLPNTFG YDE P + L FA DGL+NIVGGCCG+TP HI I +AV+ PR+PP T FE ++LSGLE F I P T FVNIGERCNVAGSR+F +LI YEEAL +AK QVE GAQV+D+NMD+GML+G AMT+F NLI+SEPDI+KVPLCIDSSNFAVIEAGLKC QGKCIVNSISLKEGE DF K + IKK+GAA+V+MAFDE+GQA + D KI +C R Y LLV K+ FNPNDIIFD NILTIGTGMEEHN Y ++FI AT+ +K+ LP A++SGG+SN+SFSFRG E +REAMH VFL+HAIK+GMDMGIVNAG LPVYDDI LL+LCED++WNK +AT++LL YA+ + +++T D WR+ V ERLE++LVKGI+K+IIEDTEEAR K + RPL++IEGPLM GM VGDLFGAGKMFLPQVIKSARVMK+AVG+LIPFME+E+ ++G E Y GT+V+ATVKGDVHDIGKNIVGVV+GCNN+RVIDLGVM P +KIL+ AL+ KAD+IGLSGLITPSL+EM+ VA+EMERL +R PLLIGGATTS+ HTAVKIAP+YS P +HVLDASKSVVV + LLD+ E+ E I EEYE+IR++HYESL ER YL + +ARK Q++W + +P F+G+++ E+ D+ L+ YIDWKPFFDVWQLRGKYPNRG+PKIFNDK VG EA+ ++ DA +L +I K L GV+GF+PA S DDI LY ++ + T +GLRQQ E++ + Y C+SDFIAP+ SG DY+G+FAV A G + L++ ++D GDDY+S+MVKAL DRLAEA AE LH VR LW Y +E L D ++ Y GIRPAPGYP+QPDH+E+ T+W L E+ GI L +SL M+PA++VSGLYFS+ KSKYF+VGKISKDQV DYA RK IS+ E EK L IL Y+TD
Sbjct: 14 LKKTLRDEINAILQKRIMVLDGGMGTMIQREKLNEEHFRGQEFKDHARPLKGNNDILSITQPDVIYQIHKEYLLAGADIIETNTFSSTSIAQADYGLEHLAYRMNMCSAGVARKAAEEVTLQTGIKRFVAGALGPTNKTLSVSPSVERPDYRNITFDELVEAYQEQAKGLLDGGVDILLIETIFDTANAKAALFALQNLFEEKYAPRPIFISGTIVDKSGRTLSGQTGEGFVISVSHGEPLCIGLNCALGAAEMRPFIEIIGKCTTAYVLCYPNAGLPNTFGDYDETPSMMAKHLKDFAMDGLVNIVGGCCGSTPDHIREIAEAVKNCKPRVPPATAFEGHMLLSGLEPFRIGPYTN-FVNIGERCNVAGSRKFAKLIMAGNYEEALCVAKVQVEMGAQVLDVNMDDGMLDGPSAMTRFCNLIASEPDIAKVPLCIDSSNFAVIEAGLKCCQGKCIVNSISLKEGEDDFLEKARKIKKYGAAMVVMAFDEEGQATETDTKIRVCTRAYHLLVKKLGFNPNDIIFDPNILTIGTGMEEHNLYAINFIHATKVIKETLPGARISGGLSNLSFSFRGMEAIREAMHGVFLYHAIKSGMDMGIVNAGNLPVYDDIHKELLQLCEDLIWNKDPEATEKLLRYAQT-QGTGGKKVIQT-DEWRNGPVEERLEYALVKGIEKHIIEDTEEARLNQKKYPRPLNIIEGPLMNGMKIVGDLFGAGKMFLPQVIKSARVMKKAVGHLIPFMEKEREETRVLNGTVEEEDPYQGTIVLATVKGDVHDIGKNIVGVVLGCNNFRVIDLGVMTPCDKILKAALDHKADIIGLSGLITPSLDEMIFVAKEMERLAIRIPLLIGGATTSKTHTAVKIAPRYSAPVIHVLDASKSVVVCSQLLDENLKDEYFEEIMEEYEDIRQDHYESLKERRYLPLSQARKSGFQMDW-LSEPHPVKPTFIGTQVFEDYDLQKLVDYIDWKPFFDVWQLRGKYPNRGFPKIFNDKTVGGEARKVYDDAHNMLNTLISQKKLRARGVVGFWPAQSIQDDIHLY-AEAAVPQAAEPIATFYGLRQQAEKDSASTEPYYCLSDFIAPLHSGIRDYLGLFAV-ACFGVEELSKAYEDDGDDYSSIMVKALGDRLAEAFAEELHERVRRELWAYCGSEQLDVADLRRLRYKGIRPAPGYPSQPDHTEKLTMWRLADIEQSTGIRL-TESLAMAPASAVSGLYFSNLKSKYFAVGKISKDQVEDYALRKNISVAEVEKWLGPILGYDTD 1265
BLAST of Methionine synthase vs. UniProt/SwissProt
Match: sp|Q9Z2Q4|METH_RAT (Methionine synthase OS=Rattus norvegicus OX=10116 GN=Mtr PE=1 SV=1) HSP 1 Score: 1596.25 bits (4132), Expect = 0.000e+0 Identity = 796/1261 (63.12%), Postives = 994/1261 (78.83%), Query Frame = 3
Query: 27 MRKNIKSVLFSTLRERIMILDGAMGTMIQTYKLEENDFRGEIFKDHPKLLRGNNDLLSLTKPDIVFNIHKEFLDSGADIIETNTFSGTAIAQADYGLEHMVYKLNYESAILARKACDLVSSKSGISRFVAGAIGPTNRTLSISPSVEKPEYRNITFDQLVTAYKEQAHALLDGGVDILLIETIFDTANAKAAVFALFEVFEEA-GYEVPVFISGTIVDKSGRNLSGQTTEAFLTSISHIKPICIGLNCALGASDMRPFIETISANTTSFVICYPNAGLPNTFGAYDEKPEYTGEILSQFAKDGLINIVGGCCGTTPAHIAAIKKAVRGYSPRIPPTTLFEDCLVLSGLERFIINPRTTLFVNIGERCNVAGSRRFLRLIKTDKYEEALSIAKEQVENGAQVIDLNMDEGMLEGKLAMTKFINLISSEPDISKVPLCIDSSNFAVIEAGLKCTQGKCIVNSISLKEGELDFYRKLKIIKKFGAAVVIMAFDEQGQAADYDRKIAICCRIYDLLVNKMDFNPNDIIFDLNILTIGTGMEEHNGYGMDFIRATEFVKKNLPHAKVSGGVSNISFSFRGKEVVREAMHSVFLFHAIKAGMDMGIVNAGCLPVYDDIEPRLLELCEDILWNKRQDATDRLLEYAENLLKSDDVGILKTEDAWRSLSVSERLEHSLVKGIDKYIIEDTEEA---RKCHVRPLHVIEGPLMRGMSTVGDLFGAGKMFLPQVIKSARVMKRAVGYLIPFMEEEKRLAMEVSGIYSNEPQYVGTMVIATVKGDVHDIGKNIVGVVMGCNNYRVIDLGVMCPSEKILQCALEEKADVIGLSGLITPSLEEMMHVAREMERLGMRTPLLIGGATTSRQHTAVKIAPKYSGPTVHVLDASKSVVVTNSLLDDTXXXXXXXXXXXXXXXXXXXXXXSLAERIYLSIDEARKRKLQLNWSIDHFQSHRPNFLGSKIVENIDINILLPYIDWKPFFDVWQLRGKYPNRGYPKIFNDKDVGKEAQILFSDAQKVLFEIIQYKLLHVNGVIGFYPAHSEGDDILLYDPDSFNVNRKNHLTTLFGLRQQEERE----DPNYLCISDFIAPIESGCDDYVGMFAVTAGIGADSLAQKFQDQGDDYNSLMVKALADRLAEASAEYLHHIVRTTLWGYSPNENLTPEDYIKVMYDGIRPAPGYPTQPDHSEQATVWDLLKPER-IGINLHKDSLGMSPAASVSGLYFSHPKSKYFSVGKISKDQVYDYAKRKQISIGESEKRLQSILSYETD 3782
M+K ++ + + LR+RIM+LDG MGTMIQ YKL E +F+G+ FKDH + L+GNND+LS+T+PD+++ IHKE+L +GADIIETNTFS T+IAQADYGLEH+ Y++N SA +ARKA + ++ ++G+ RFVAG++GPTN+TLS+SPSVE+P+YRNITFD+LV AY+EQA LLDGGVDILLIETIFDTANAKAA+FAL ++FEE P+FISGTIVDKSGR LSGQT EAF+TS+SH P+CIGLNCALGA++MRPFIETI TT++V+CYPNAGLPNTFG YDE P L FA DGL+N+VGGCCG+TP HI I +AV+ PR+PP ++FE ++LSGLE F I P T FVNIGERCNVAGS++F +LI YEEALS+AK QVE GAQV+D+NMD+GML+G AMTKF N I+SEPDI+KVPLCIDSSNFAVIEAGLKC QGKCIVNSISLKEGE DF K + IKKFGAAVV+MAFDE+GQA + D K+++C R Y LLV K+ FNPNDIIFD NILTIGTGMEEHN Y ++FI AT +K+ LP ++SGG+SN+SF+FRG + +REAMH VFL+HAIK GMDMGIVNAG LPVYDDI LL+LCED++WN+ +AT++LL YA+ K +++T D WR+ S+ ERLE++LVKGI+K+I+EDTEEA R+ + RPL++IEGPLM GM VGDLFGAGKMFLPQVIKSARVMK+AVG+LIPFME+E+ A ++G E Y GT+V+ATVKGDVHDIGKNIVGVV+GCNN+RVIDLGVM P +KILQ AL+ KAD+IGLSGLITPSL+EM+ VA+EMERL ++ PLLIGGATTSR HTAVKIAP+YS P +HVLDASKSVVV + LLD+ ++ E I EEYE+IR++HYESL ER YL + +ARK ++W + +P F+G+++ E+ ++ L+ YIDWKPFFDVWQLRGKYPNRG+PKIFNDK VG+EA+ ++ DAQ +L +I K L GV+GF+PA S DDI LY + + T +GLRQQ E++ DP Y C+SDF+AP+ SG DY+G+FAV A G + L++ ++D GDDY+S+MVKAL DRLAEA AE LH VR LW Y +E L D K+ Y+GIRPAPGYP+QPDH+E+ T+W L E+ GI L +SL M+PA++VSGLYFS+ KSKYF+VGKISKDQ+ DYA RK +S+ E EK L IL Y+TD
Sbjct: 1 MKKTLQDEIEAILRKRIMVLDGGMGTMIQRYKLSEENFQGQEFKDHSRPLKGNNDILSITQPDVIYQIHKEYLLAGADIIETNTFSSTSIAQADYGLEHLAYRMNKCSADVARKAAEEITLQTGVKRFVAGSLGPTNKTLSVSPSVERPDYRNITFDELVEAYQEQAKGLLDGGVDILLIETIFDTANAKAALFALQKLFEENYASPRPIFISGTIVDKSGRTLSGQTGEAFVTSVSHSDPLCIGLNCALGAAEMRPFIETIGKCTTAYVLCYPNAGLPNTFGDYDETPAMMAMHLKDFAVDGLVNVVGGCCGSTPDHIREIAEAVKNCKPRVPPDSVFEGHMLLSGLEPFRIGPYTN-FVNIGERCNVAGSKKFAKLIMAGNYEEALSVAKVQVEMGAQVLDINMDDGMLDGPSAMTKFCNFIASEPDIAKVPLCIDSSNFAVIEAGLKCCQGKCIVNSISLKEGEEDFLEKARKIKKFGAAVVVMAFDEEGQATETDVKVSVCTRAYHLLVEKVGFNPNDIIFDPNILTIGTGMEEHNLYAINFIHATRVIKETLPGVRISGGLSNLSFAFRGMDAIREAMHGVFLYHAIKFGMDMGIVNAGSLPVYDDIHKDLLQLCEDLIWNRDAEATEKLLRYAQTHGKGGK-KVIQT-DEWRNGSIEERLEYALVKGIEKHIVEDTEEARLNREKYPRPLNIIEGPLMNGMKVVGDLFGAGKMFLPQVIKSARVMKKAVGHLIPFMEKEREEARVLNGSVEEEDPYQGTIVLATVKGDVHDIGKNIVGVVLGCNNFRVIDLGVMTPCDKILQAALDHKADIIGLSGLITPSLDEMIFVAKEMERLAIKIPLLIGGATTSRTHTAVKIAPRYSAPVIHVLDASKSVVVCSQLLDENLKDDYFEEILEEYEDIRQDHYESLKERKYLPLSQARKHSFHIDW-LSEPHPVKPTFIGTQVFEDYNLQKLVDYIDWKPFFDVWQLRGKYPNRGFPKIFNDKAVGEEARKVYEDAQNMLSILISRKKLRARGVVGFWPAQSVQDDIHLYAEGAVP-QAAEPIATFYGLRQQAEKDSSSTDP-YHCLSDFVAPLHSGVRDYLGLFAV-ACFGVEELSKAYEDDGDDYSSIMVKALGDRLAEAFAEELHERVRRELWAYCGSEQLGVTDLRKLRYEGIRPAPGYPSQPDHTEKLTMWRLANIEQATGIRL-TESLAMAPASAVSGLYFSNVKSKYFAVGKISKDQIEDYALRKNMSVAEVEKWLGPILGYDTD 1253
BLAST of Methionine synthase vs. UniProt/SwissProt
Match: sp|A6H5Y3|METH_MOUSE (Methionine synthase OS=Mus musculus OX=10090 GN=Mtr PE=1 SV=1) HSP 1 Score: 1582.77 bits (4097), Expect = 0.000e+0 Identity = 795/1261 (63.05%), Postives = 989/1261 (78.43%), Query Frame = 3
Query: 27 MRKNIKSVLFSTLRERIMILDGAMGTMIQTYKLEENDFRGEIFKDHPKLLRGNNDLLSLTKPDIVFNIHKEFLDSGADIIETNTFSGTAIAQADYGLEHMVYKLNYESAILARKACDLVSSKSGISRFVAGAIGPTNRTLSISPSVEKPEYRNITFDQLVTAYKEQAHALLDGGVDILLIETIFDTANAKAAVFALFEVFEEA-GYEVPVFISGTIVDKSGRNLSGQTTEAFLTSISHIKPICIGLNCALGASDMRPFIETISANTTSFVICYPNAGLPNTFGAYDEKPEYTGEILSQFAKDGLINIVGGCCGTTPAHIAAIKKAVRGYSPRIPPTTLFEDCLVLSGLERFIINPRTTLFVNIGERCNVAGSRRFLRLIKTDKYEEALSIAKEQVENGAQVIDLNMDEGMLEGKLAMTKFINLISSEPDISKVPLCIDSSNFAVIEAGLKCTQGKCIVNSISLKEGELDFYRKLKIIKKFGAAVVIMAFDEQGQAADYDRKIAICCRIYDLLVNKMDFNPNDIIFDLNILTIGTGMEEHNGYGMDFIRATEFVKKNLPHAKVSGGVSNISFSFRGKEVVREAMHSVFLFHAIKAGMDMGIVNAGCLPVYDDIEPRLLELCEDILWNKRQDATDRLLEYAENLLKSDDVGILKTEDAWRSLSVSERLEHSLVKGIDKYIIEDTEEAR---KCHVRPLHVIEGPLMRGMSTVGDLFGAGKMFLPQVIKSARVMKRAVGYLIPFMEEEKRLAMEVSGIYSNEPQYVGTMVIATVKGDVHDIGKNIVGVVMGCNNYRVIDLGVMCPSEKILQCALEEKADVIGLSGLITPSLEEMMHVAREMERLGMRTPLLIGGATTSRQHTAVKIAPKYSGPTVHVLDASKSVVVTNSLLDDTXXXXXXXXXXXXXXXXXXXXXXSLAERIYLSIDEARKRKLQLNWSIDHFQSHRPNFLGSKIVENIDINILLPYIDWKPFFDVWQLRGKYPNRGYPKIFNDKDVGKEAQILFSDAQKVLFEIIQYKLLHVNGVIGFYPAHSEGDDILLYDPDSFNVNRKNHLTTLFGLRQQEERE----DPNYLCISDFIAPIESGCDDYVGMFAVTAGIGADSLAQKFQDQGDDYNSLMVKALADRLAEASAEYLHHIVRTTLWGYSPNENLTPEDYIKVMYDGIRPAPGYPTQPDHSEQATVWDLLKPER-IGINLHKDSLGMSPAASVSGLYFSHPKSKYFSVGKISKDQVYDYAKRKQISIGESEKRLQSILSYETD 3782
M+K ++ + + LR+RIM+LDG MGTMIQ YKL E F+G+ FKDH + L+GNND+LS+T+PDI++ IHKE+L +GADIIETNTFS T+IAQADYGLEH+ Y++N SA +ARKA + ++ ++G+ RFVAGA+GPTN+TLS+SPSVE+P+YRNITFD+LV AY+EQA LLDG VDILLIETIFDTANAKAA+FA+ +FEE P+FISGTIVDKSGR LSGQT EAF+TS+SH P+CIGLNC+LGA++MRPFIETI TT++V+CYPNAGLPNTFG YDE P L FA DGL+NIVGGCCG+TP HI I +AV+ PR+PP ++FE ++LSGLE F I P T FVNIGERCNVAGSR+F +LI YEEALSIAK QVE GAQV+D+NMD+GML+G AMT+F N I+SEPDI+KVPLCIDSSNFAVIEAGLKC QGKCIVNSISLKEGE DF K + IKKFGAAVV+MAFDE+GQA + D K+ +C R Y LLV+K+ FNPNDIIFD NILTIGTGMEEHN Y ++FI AT +K+ LP ++SGG+SN+SFSFRG E +REAMH VFL+HAIK GMDMGIVNAG LPVYD I LL+LCED++WNK +AT++LL YA+ + +++T D WR+ S+ ERLE++LVKGI+K+I+EDTEEAR + + RPL++IEGPLM GM VGDLFGAGKMFLPQVIKSARVMK+AVG+LIPFME+E+ A ++G E Y GT+V+ATVKGDVHDIGKNIVGVV+ CNN+RVIDLGVM P +KILQ AL+ KAD+IGLSGLITPSL+EM+ VA+EMERL ++ PLLIGGATTSR HTAVKIAP+YS P +HVLDASKSVVV + LLD+ ++ E I EEYE+IR++HYESL ER Y+ + +ARK ++W + +P F+G+++ E+ ++ L+ YIDWKPFFDVWQLRGKYPNRG+PKIFNDK VG+EA+ +++DAQ +L +I K L GV+GF+PA S DDI LY + + T +GLRQQ E++ DP Y C+SDFIAP+ SG DY+G+FAV A G + L++ ++D GDDY+S+MVKAL DRLAEA AE LH VR LW YS +E L D ++ Y+GIRPAPGYP+QPDH+E+ T+W L E+ GI L +SL M+PA++VSGLYFS+ K+KYF+VGKISKDQ DYA RK + + E EK L IL Y+TD
Sbjct: 1 MKKTLQDEIEAILRKRIMVLDGGMGTMIQRYKLSEEHFQGQEFKDHSRPLKGNNDILSITQPDIIYQIHKEYLLAGADIIETNTFSSTSIAQADYGLEHLAYRMNKCSADVARKAAEEITLQTGVKRFVAGALGPTNKTLSVSPSVERPDYRNITFDELVDAYQEQAKGLLDGRVDILLIETIFDTANAKAALFAIQNLFEENYAPPRPIFISGTIVDKSGRTLSGQTGEAFVTSVSHSDPLCIGLNCSLGAAEMRPFIETIGKCTTAYVLCYPNAGLPNTFGDYDETPSTMATHLKDFAVDGLVNIVGGCCGSTPDHIREIAEAVKKCKPRVPPASVFEGHMLLSGLEPFRIGPYTN-FVNIGERCNVAGSRKFAKLIMAGNYEEALSIAKAQVEMGAQVLDINMDDGMLDGPSAMTRFCNSIASEPDIAKVPLCIDSSNFAVIEAGLKCCQGKCIVNSISLKEGEGDFLEKARKIKKFGAAVVVMAFDEEGQATETDVKVNVCTRAYHLLVDKVGFNPNDIIFDPNILTIGTGMEEHNLYAINFIHATRVIKETLPGVRISGGLSNLSFSFRGMEAIREAMHGVFLYHAIKFGMDMGIVNAGNLPVYDAIHKDLLQLCEDLIWNKDSEATEKLLRYAQT-HGTGGKKVIQT-DEWRNGSIEERLEYALVKGIEKHIVEDTEEARLNGEKYPRPLNIIEGPLMNGMKVVGDLFGAGKMFLPQVIKSARVMKKAVGHLIPFMEKEREEARLINGSVEEEDPYQGTIVLATVKGDVHDIGKNIVGVVLACNNFRVIDLGVMTPCDKILQAALDHKADIIGLSGLITPSLDEMIFVAKEMERLAIKIPLLIGGATTSRTHTAVKIAPRYSAPVIHVLDASKSVVVCSQLLDENLRDDYFEEILEEYEDIRQDHYESLKERKYVPLSQARKHGFHIDW-LSEPHPVKPTFIGTQVFEDYNLQKLVDYIDWKPFFDVWQLRGKYPNRGFPKIFNDKAVGEEARKVYNDAQNMLNILISQKKLQARGVVGFWPAQSVQDDIHLY-AEGVVPQAAEPIATFYGLRQQAEKDSSSTDP-YHCLSDFIAPLHSGVCDYLGLFAV-ACFGVEELSKTYEDDGDDYSSIMVKALGDRLAEAFAEELHERVRRELWAYSRSEQLGVPDLRRLRYEGIRPAPGYPSQPDHTEKLTMWRLASIEQATGIRL-TESLAMAPASAVSGLYFSNVKAKYFAVGKISKDQTEDYALRKNMPVAEVEKWLGPILGYDTD 1253
BLAST of Methionine synthase vs. UniProt/SwissProt
Match: sp|Q09582|METH_CAEEL (Probable methionine synthase OS=Caenorhabditis elegans OX=6239 GN=metr-1 PE=3 SV=1) HSP 1 Score: 1543.1 bits (3994), Expect = 0.000e+0 Identity = 765/1257 (60.86%), Postives = 982/1257 (78.12%), Query Frame = 3
Query: 42 KSVLFSTL----RERIMILDGAMGTMIQTYKLEENDFRGEIFKDHPKLLRGNNDLLSLTKPDIVFNIHKEFLDSGADIIETNTFSGTAIAQADYGLEHMVYKLNYESAILARKACDLVSSKSGISRFVAGAIGPTNRTLSISPSVEKPEYRNITFDQLVTAYKEQAHALLDGGVDILLIETIFDTANAKAAVFALFEVFEEAGY-EVPVFISGTIVDKSGRNLSGQTTEAFLTSISHIKPICIGLNCALGASDMRPFIETISANTTSFVICYPNAGLPNTFGAYDEKPEYTGEILSQFAKDGLINIVGGCCGTTPAHIAAIKKAVRGYSPRIPPTTLFEDCLVLSGLERFIINPRTTLFVNIGERCNVAGSRRFLRLIKTDKYEEALSIAKEQVENGAQVIDLNMDEGMLEGKLAMTKFINLISSEPDISKVPLCIDSSNFAVIEAGLKCTQGKCIVNSISLKEGELDFYRKLKIIKKFGAAVVIMAFDEQGQAADYDRKIAICCRIYDLLVNKMDFNPNDIIFDLNILTIGTGMEEHNGYGMDFIRATEFVKKNLPHAKVSGGVSNISFSFRGKEVVREAMHSVFLFHAIKAGMDMGIVNAGCLPVYDDIEPRLLELCEDILWNKRQDATDRLLEYAENLLKSDDVGILKTEDAWRSLSVSERLEHSLVKGIDKYIIEDTEEARKC---HVRPLHVIEGPLMRGMSTVGDLFGAGKMFLPQVIKSARVMKRAVGYLIPFMEEEKRLAMEVSGIYSNEPQYVGTMVIATVKGDVHDIGKNIVGVVMGCNNYRVIDLGVMCPSEKILQCALEEKADVIGLSGLITPSLEEMMHVAREMERLGMRTPLLIGGATTSRQHTAVKIAPKYSGPTVHVLDASKSVVVTNSLLDDTXXXXXXXXXXXXXXXXXXXXXXSLAERIYLSIDEARKRKLQLNWSIDHFQSHRPNFLGSKIVENIDINILLPYIDWKPFFDVWQLRGKYPNRGYPKIFNDKDVGKEAQILFSDAQKVLFEIIQYKLLHVNGVIGFYPAHSEGDDILLYDPDSFNVNRKNHLTTLFGLRQQEERE-DPNYLCISDFIAPIESGC-DDYVGMFAVTAGIGADSLAQKFQDQGDDYNSLMVKALADRLAEASAEYLHHIVRTTLWGYSPNENLTPEDYIKVMYDGIRPAPGYPTQPDHSEQATVWDLLKPERIGINLHKDSLGMSPAASVSGLYFSHPKSKYFSVGKISKDQVYDYAKRKQISIGESEKRLQSILSYETD 3782
+S LF L +ERIMI+DGAMGTMIQ +EE DFRGEI KDH K L+GNNDLLS+T+PDI++ IHK +L++GAD +ETNTFSGT IAQADY EH+V+++NY+SA++AR+ACD V + +G R+V GAIGPTNRTLSISPSVEKP++RN+TF +LV AY +QA +L+ GGVD+LL+ET+FD+ANAKAA+FA+ +FE+ G E+PVF+SGTIVD SGR LSGQT EAFL S KP+ +GLNCALGA DMR F++ +S + SF+ICYPNAGLPN G YDE PE ++L +FA+DGL+NI+GGCCGTTP HI A+ KAV+G +PR+PP ++LSGLE I+ P T FVNIGERCNVAGSRRF LIK + Y+ A+ +A+ QV++GAQ++D+NMD+G+L+G AM+KF+ LISSEPD++K+P+CIDSS+F VI AGL+ TQGKC+VNSISLKEGE F + +IIK++GAAVV+MAFDEQGQAA+ D K IC R Y +L ++ FNPNDIIFD NILTI TGMEEH+ YGM FI A +++NLP A VSGGVSNISFSFRG E +REAMHSVFLF+AIKAGMDMGIVNAG LPVY+DI+ LL+L ED+L+N+ +AT++LL A+ + K KT D WRSL+V ERL+ +LVKG+D++++ DTEEAR+ + RPL+VIE PLM GM+ VG+LFGAGKMFLPQVIKSARVMK+AV +L+PFME E++ +E G+ +E Y GT+VIATVKGDVHDIGKNIV VV+GCNN++V+DLGVM P E I++ A+EEKAD IGLSGLITPSL+EM++VA+EM R+G+ PLLIGGATTS+ HTAVKI+P+Y P VH LDASKSVVV +SL D + F +++ E+YE++R+EHY SL +R + +++ R++K +++W D F + +P+F+G + +N D+N L+PYIDWKPFFDVWQLRGKYPNR YPKIF+D DVG EA+ +F DAQ L ++I K+L N V+ F PA SEGDD+ +YDP++ N L T +GLRQQ RE D + C+SDFI P+++G DDY+G+FA TAG+GA+ + + DDY S+MVKALADRLAEA AEYLH VRTTLWGYS NE+LT D + + Y GIRPA GYP+QPDH+E+ T+W LL+ E+ GI L + L M PAASVSGLYF++P+S+YF+VGKI +DQV DYA RK + E E+ L IL Y+TD
Sbjct: 3 RSSLFEELAEIAKERIMIIDGAMGTMIQREYMEEEDFRGEILKDHDKPLKGNNDLLSITRPDIIYKIHKLYLEAGADFVETNTFSGTTIAQADYRCEHLVHEINYQSALVARRACDDVGAATGRRRYVCGAIGPTNRTLSISPSVEKPDFRNVTFQELVKAYGDQARSLIQGGVDVLLVETVFDSANAKAALFAIRTLFEDEGVPEMPVFLSGTIVDMSGRTLSGQTGEAFLVSTKQGKPMAVGLNCALGAKDMRQFVDNMSKWSDSFIICYPNAGLPNALGGYDETPEEMADVLREFARDGLVNIIGGCCGTTPDHINAMYKAVQGITPRVPPQDPHAGKMLLSGLEPSIVGPETN-FVNIGERCNVAGSRRFCNLIKNENYDTAIDVARVQVDSGAQILDVNMDDGLLDGPYAMSKFLRLISSEPDVAKIPVCIDSSDFDVIIAGLESTQGKCVVNSISLKEGEEKFKERARIIKRYGAAVVVMAFDEQGQAAETDPKFEICERSYRILTEEVGFNPNDIIFDANILTIATGMEEHSNYGMYFIEAARMIRENLPGAHVSGGVSNISFSFRGMEAIREAMHSVFLFYAIKAGMDMGIVNAGALPVYEDIDKPLLQLLEDLLFNRDPEATEKLLVAAQEMKKDGKKADTKT-DEWRSLTVEERLKFALVKGVDQFVVADTEEARQNTAKYPRPLNVIERPLMDGMAVVGELFGAGKMFLPQVIKSARVMKKAVAHLLPFMEIERQANIETMGLAEDESPYQGTVVIATVKGDVHDIGKNIVSVVLGCNNFKVVDLGVMTPCENIIKAAIEEKADFIGLSGLITPSLDEMVYVAKEMNRVGLNIPLLIGGATTSKTHTAVKISPRYPHPVVHCLDASKSVVVCSSLSDMSVRDAFLQDLNEDYEDVRQEHYASLKDRRFTDLNKTREKKFKIDW--DKFTAVKPSFVGRREYQNFDLNELIPYIDWKPFFDVWQLRGKYPNRSYPKIFDDADVGAEAKKVFDDAQTWLKKLIDEKILVANAVVSFLPAASEGDDMHVYDPET-----GNKLDTFYGLRQQSGREHDQPHFCLSDFIKPLKNGVPDDYLGLFACTAGLGAEEYCKTLEKNHDDYASIMVKALADRLAEAYAEYLHKEVRTTLWGYSTNEDLTESDLLSIKYQGIRPACGYPSQPDHTEKRTLWKLLEAEKNGIGL-TEHLAMLPAASVSGLYFANPQSEYFAVGKIDQDQVIDYAARKNVPKEEVERWLSPILGYDTD 1249
BLAST of Methionine synthase vs. TrEMBL
Match: A0A2C9JEV6 (Methionine synthase OS=Biomphalaria glabrata OX=6526 GN=106055438 PE=4 SV=1) HSP 1 Score: 1659.81 bits (4297), Expect = 0.000e+0 Identity = 825/1260 (65.48%), Postives = 1008/1260 (80.00%), Query Frame = 3
Query: 33 KNIKSVLFSTLRERIMILDGAMGTMIQTYKLEENDFRGEIFKDHPKLLRGNNDLLSLTKPDIVFNIHKEFLDSGADIIETNTFSGTAIAQADYGLEHMVYKLNYESAILARKACDLVSSKSGISRFVAGAIGPTNRTLSISPSVEKPEYRNITFDQLVTAYKEQAHALLDGGVDILLIETIFDTANAKAAVFALFEVFEEAGYEVPVFISGTIVDKSGRNLSGQTTEAFLTSISHIKPICIGLNCALGASDMRPFIETISANTTSFVICYPNAGLPNTFGAYDEKPEYTGEILSQFAKDGLINIVGGCCGTTPAHIAAIKKAVRGYSPRIPPTTLFEDCLVLSGLERFIINPRTTLFVNIGERCNVAGSRRFLRLIKTDKYEEALSIAKEQVENGAQVIDLNMDEGMLEGKLAMTKFINLISSEPDISKVPLCIDSSNFAVIEAGLKCTQGKCIVNSISLKEGELDFYRKLKIIKKFGAAVVIMAFDEQGQAADYDRKIAICCRIYDLLVNKMDFNPNDIIFDLNILTIGTGMEEHNGYGMDFIRATEFVKKNLPHAKVSGGVSNISFSFRGKEVVREAMHSVFLFHAIKAGMDMGIVNAGCLPVYDDIEPRLLELCEDILWNKRQDATDRLLEYAENLLKSDDVGILKT--EDAWRSLSVSERLEHSLVKGIDKYIIEDTEEARK---CHVRPLHVIEGPLMRGMSTVGDLFGAGKMFLPQVIKSARVMKRAVGYLIPFMEEEKRLAMEVSGIYSN-EPQYVGTMVIATVKGDVHDIGKNIVGVVMGCNNYRVIDLGVMCPSEKILQCALEEKADVIGLSGLITPSLEEMMHVAREMERLGMRTPLLIGGATTSRQHTAVKIAPKYSGPTVHVLDASKSVVVTNSLLDDTXXXXXXXXXXXXXXXXXXXXXXSLAERIYLSIDEARKRKLQLNWSIDHFQSHRPNFLGSKIVENIDINILLPYIDWKPFFDVWQLRGKYPNRGYPKIFNDKDVGKEAQILFSDAQKVLFEIIQYKLLHVNGVIGFYPAHSEGDDILLYDPDSFNVNRKNHLTTLFGLRQQEEREDPN---YLCISDFIAPIESGCDDYVGMFAVTAGIGADSLAQKFQDQGDDYNSLMVKALADRLAEASAEYLHHIVRTTLWGYSPNENLTPEDYIKVMYDGIRPAPGYPTQPDHSEQATVWDLLKPERIGINLHKDSLGMSPAASVSGLYFSHPKSKYFSVGKISKDQVYDYAKRKQISIGESEKRLQSILSYETDE 3785
++I L TL+ RIMI DG MGTMIQ +L E DFRG IFKDHP+ L+GNNDLL LT+PD+V IHKE+L +GAD IETNTFSGT+IAQ+DYGLE VY++N E+A LAR+ACD VS ++G++R+VAGAIGPTNRTLSISPSVE PE RNITFD+LV AY EQA LLDGG D+LL+ETIFDTANAKAA+FA+ VFE VPV++SGTIVDKSGR LSGQTTEAF+ S+SH +P+C+GLNCALGA +MRPF+E++S NTT++V+CYPNAGLPNTFG YDE PE T + F KDGLINI+GGCCGT P HI AI + + + PR+PP L L LSGLE F I+P T FVNIGERCNVAGSRRF RLIK K+EEALS+AKEQV+NGAQ+ID+NMDEGML+G AMT ++NLI+SEP+I+KVPLCIDSSNFAVIEAGLKCTQGKCIVNSISLKEGE DF RK +IIKK+GAAVVIMAFDE GQAAD +RK++IC R Y+LL K+ FNPNDIIFD NILTI TG+EEHN YG++FI AT +KK LP A+VSGGVSN SFSFRG E +REAMHSVFLFHAIKAG+DMGIVNAG LPVYDDIEP LL+LCE++LWNK D T++LL YA+ KS G+ K +D WRS V ERL +SLVKGIDKY+IEDTEEAR+ + RPL+VIEGPLM+GM+ VGDLFG+GKMFLPQVIKSARVMK+AVG+LIP+ME+E++ +M+ G+ + EP Y GT+VIATVKGDVHDIGKNIV VV+GCNNY+VIDLGVMCP E I++ A++EKAD IG+SGLITPSL+EM++ +E ER+G+ P+LIGGATTS+QHTAVKIAP+ + P VHVLDASK+VVV ++L D T EF E + EEYEEIR+EHYESL +R YL + +AR++KL ++WS +P+F+G K EN D+ L+PYIDW+PFF+VWQLRGKYPNRGYPKIFNDK+VG+EA+ +F+DAQK++ +II+ K L I FYPA+S GDDI +YD + TLFGLRQQ E+E + YLC SDFIA ESG DY+G+FA T+GIG + L Q+++ Q DDYN +MVKA+ADRLAEA AEYLH VR WGYS EN P+D ++ Y GIRPA GYP+QPDH+E+ T+W L++P+ +GI L DSL M PA+SVSG+Y ++P+S YF+ K+ KDQ+ DYA+RKQI + +EK L+S L+Y+ DE
Sbjct: 15 RDIFKELECTLKNRIMIFDGGMGTMIQRERLAEEDFRGTIFKDHPRNLKGNNDLLCLTRPDVVLKIHKEYLYAGADFIETNTFSGTSIAQSDYGLEKYVYRINKEAAELARRACDEVSIQTGVTRYVAGAIGPTNRTLSISPSVEHPEMRNITFDELVEAYTEQARGLLDGGADVLLVETIFDTANAKAALFAIDNVFEMGYPGVPVYVSGTIVDKSGRTLSGQTTEAFIISVSHAQPMCLGLNCALGAREMRPFVESVSKNTTAYVLCYPNAGLPNTFGEYDETPEQTASYIQDFIKDGLINIIGGCCGTQPGHIKAIAEVAKKFKPRVPPLELHSGHLCLSGLEPFYISPLTN-FVNIGERCNVAGSRRFCRLIKDRKFEEALSVAKEQVQNGAQIIDINMDEGMLDGVSAMTTYVNLITSEPEIAKVPLCIDSSNFAVIEAGLKCTQGKCIVNSISLKEGEDDFLRKARIIKKYGAAVVIMAFDEVGQAADTERKVSICTRSYNLLTQKLGFNPNDIIFDPNILTIATGIEEHNIYGINFIEATAIIKKTLPGARVSGGVSNFSFSFRGMEAIREAMHSVFLFHAIKAGLDMGIVNAGALPVYDDIEPELLKLCENLLWNKDPDGTEKLLAYAQTKSKS---GMTKASQDDEWRSKPVEERLSYSLVKGIDKYVIEDTEEARQNTALYPRPLNVIEGPLMKGMAVVGDLFGSGKMFLPQVIKSARVMKKAVGHLIPYMEKERQESMKAQGLPEDAEPSYQGTVVIATVKGDVHDIGKNIVSVVLGCNNYKVIDLGVMCPCESIIEAAIKEKADYIGMSGLITPSLDEMIYNVKEFERVGLNIPVLIGGATTSKQHTAVKIAPRKTSPVVHVLDASKAVVVVSALGDQTSRDEFIEELSEEYEEIREEHYESLKDRKYLPLSKAREKKLVIDWSKTPLPV-KPSFIGVKKFENFDLQELVPYIDWRPFFNVWQLRGKYPNRGYPKIFNDKEVGEEAKRIFNDAQKIIEKIIKEKKLQAAATIAFYPANSVGDDIEVYD------ETGKKIATLFGLRQQAEKESSDNSPYLCQSDFIASKESGITDYIGLFACTSGIGTEQLCQEYETQFDDYNVIMVKAVADRLAEAFAEYLHLKVRKEYWGYSHEENSNPDDLHRLKYQGIRPAAGYPSQPDHTEKTTMWQLMRPDEVGITL-TDSLAMEPASSVSGIYLANPQSFYFATDKLCKDQIIDYAQRKQIDLTVAEKWLRSNLAYDDDE 1262
BLAST of Methionine synthase vs. TrEMBL
Match: K1P5E0 (Methionine synthase OS=Crassostrea gigas OX=29159 GN=CGI_10010551 PE=4 SV=1) HSP 1 Score: 1652.11 bits (4277), Expect = 0.000e+0 Identity = 807/1252 (64.46%), Postives = 1000/1252 (79.87%), Query Frame = 3
Query: 33 KNIKSVLFSTLRERIMILDGAMGTMIQTYKLEENDFRGEIFKDHPKLLRGNNDLLSLTKPDIVFNIHKEFLDSGADIIETNTFSGTAIAQADYGLEHMVYKLNYESAILARKACDLVSSKSGISRFVAGAIGPTNRTLSISPSVEKPEYRNITFDQLVTAYKEQAHALLDGGVDILLIETIFDTANAKAAVFALFEVFEEAGYEVPVFISGTIVDKSGRNLSGQTTEAFLTSISHIKPICIGLNCALGASDMRPFIETISANTTSFVICYPNAGLPNTFGAYDEKPEYTGEILSQFAKDGLINIVGGCCGTTPAHIAAIKKAVRGYSPRIPPTTLFEDCLVLSGLERFIINPRTTLFVNIGERCNVAGSRRFLRLIKTDKYEEALSIAKEQVENGAQVIDLNMDEGMLEGKLAMTKFINLISSEPDISKVPLCIDSSNFAVIEAGLKCTQGKCIVNSISLKEGELDFYRKLKIIKKFGAAVVIMAFDEQGQAADYDRKIAICCRIYDLLVNKMDFNPNDIIFDLNILTIGTGMEEHNGYGMDFIRATEFVKKNLPHAKVSGGVSNISFSFRGKEVVREAMHSVFLFHAIKAGMDMGIVNAGCLPVYDDIEPRLLELCEDILWNKRQDATDRLLEYAENLLKSDDVGILKTEDAWRSLSVSERLEHSLVKGIDKYIIEDTEEARK---CHVRPLHVIEGPLMRGMSTVGDLFGAGKMFLPQVIKSARVMKRAVGYLIPFMEEEKRLAMEVSGIYSNEPQYVGTMVIATVKGDVHDIGKNIVGVVMGCNNYRVIDLGVMCPSEKILQCALEEKADVIGLSGLITPSLEEMMHVAREMERLGMRTPLLIGGATTSRQHTAVKIAPKYSGPTVHVLDASKSVVVTNSLLDDTXXXXXXXXXXXXXXXXXXXXXXSLAERIYLSIDEARKRKLQLNWSIDHFQSHRPNFLGSKIVENIDINILLPYIDWKPFFDVWQLRGKYPNRGYPKIFNDKDVGKEAQILFSDAQKVLFEIIQYKLLHVNGVIGFYPAHSEGDDILLYDPDSFNVNRKNHLTTLFGLRQQEEREDPN---YLCISDFIAPIESGCDDYVGMFAVTAGIGADSLAQKFQDQGDDYNSLMVKALADRLAEASAEYLHHIVRTTLWGYSPNENLTPEDYIKVMYDGIRPAPGYPTQPDHSEQATVWDLLKPERIGINLHKDSLGMSPAASVSGLYFSHPKSKYFSVGKISKDQVYDYAKRKQISIGESEKRLQSILS 3770
+ ++ + STL+ERIMI DG MGTMIQ ++LEE DFRG+ FKDH K L+GNND+L LT+P +VF IHK++ ++GAD +ETNTFSGT IAQADYG EH+ Y+LNYE+A +A++A + V++K+GI ++VAGA+GPTNRTLSISPSVEKPE+RN+TFD+LV AY EQA LL+GG D+LL+ETIFDTAN+KAA+FA+ E+F + + PVF+SGTIVDKSGR LSGQTTEAFL S+SH P+CIGLNCALGA++MRPFIE +S NTT++ ICYPNAGLPNTFG YDE PE E LS FA+DGL+NIVGGCCGTTP HI AI + V + PR+PP L +D ++LSGLE + P T FVNIGERCNVAGSR+F RLIK YEEALSIAK QVENGAQ++D+NMDEGML+G MTKF+NL++SEP+ISKVPLCIDSSNFAVIEAGLKCTQGKCIVNSIS+KEGE DF K + IK++GAAVV+MAFDE+GQA RK IC R Y +LV+K+ FNPNDIIFD NILTI TG+EEHN YG+DFI AT+ +K+NLP A+VSGGVSN SFSFRG E VREAMHSVFL+HAIK GMDMGIVNAGCLPVYDDIEP+LLE+CE++LWNK D T++LL YA+++ K ++ D WR+ +V ERLE SL+KGIDK+++EDTEEAR+ + RPL+VIEGPLM+GMS VGDLFGAGKMFLPQVIKSARVMK+AVG+LIPFME+EK M+ +G + E Y G +V+ATVKGDVHDIGKNIVGVV+ CNN++VIDLGVM P EKILQ A+EE AD+IGLSGLITPSL+EM++VA+EMER+G + PLLIGGATTS+ HTAVKIAP+Y PTVHVLDASKSVVV + LLD+ +++ E + E+Y EIR +HY SL +R YLSI++AR++KL ++WS + + P+ +G K EN D++ L+PYIDWKPFFDVWQLRGKYPNRGYPKIF DK VG EA+ +++DAQ +L II L +GV+ F+PA+S GDDI +Y+ + + L GLRQQ E+E + YLC+SDF+AP SG DY+GMFAVTAG G D + + ++++ DDY +MVKALADRLAEA AE LH VR +WGYS E L D K+ Y GIRPAPGYP+QPDH+E+ +W LLK +++GI L +SL M PAASVSGLYF+HPKS+YF+ GK+ KDQ+ DY+ RK + + +EK L S L+
Sbjct: 13 ETVRDKIQSTLQERIMIFDGGMGTMIQKHRLEEEDFRGQEFKDHLKSLKGNNDILVLTQPKLVFEIHKDYFEAGADFVETNTFSGTKIAQADYGTEHLTYRLNYEAAKIAKRAAEEVTNKTGIQKYVAGAMGPTNRTLSISPSVEKPEFRNVTFDELVEAYTEQAKGLLEGGADVLLVETIFDTANSKAALFAIEELFRKEKFTCPVFVSGTIVDKSGRTLSGQTTEAFLISVSHGNPMCIGLNCALGANEMRPFIEAVSKNTTAYTICYPNAGLPNTFGDYDETPESMCEQLSNFARDGLLNIVGGCCGTTPEHIKAIAEGVSQFKPRVPPDELRKDFMMLSGLEPTYLGPYTN-FVNIGERCNVAGSRKFARLIKDGDYEEALSIAKTQVENGAQILDINMDEGMLDGVACMTKFVNLVASEPEISKVPLCIDSSNFAVIEAGLKCTQGKCIVNSISMKEGEEDFVEKARKIKQYGAAVVVMAFDEEGQATGRQRKFEICQRSYRILVDKVKFNPNDIIFDPNILTIATGIEEHNSYGVDFIMATKDIKENLPGARVSGGVSNFSFSFRGMEAVREAMHSVFLYHAIKNGMDMGIVNAGCLPVYDDIEPKLLEMCENLLWNKDPDGTEKLLAYAQSMGKDAKKAVVS--DEWRNKNVEERLEFSLIKGIDKFVVEDTEEARQNQELYPRPLNVIEGPLMKGMSVVGDLFGAGKMFLPQVIKSARVMKKAVGHLIPFMEKEKEERMKRTG--NVESGYSGVIVLATVKGDVHDIGKNIVGVVLACNNFKVIDLGVMTPCEKILQTAMEENADIIGLSGLITPSLDEMIYVAKEMERIGFKVPLLIGGATTSKTHTAVKIAPQYKSPTVHVLDASKSVVVCSQLLDEENREDYMEEVTEDYAEIRTDHYNSLKDRKYLSIEKAREKKLNIDWSA-YPPAPEPSVIGVKRFENYDLSRLVPYIDWKPFFDVWQLRGKYPNRGYPKIFKDKTVGPEAKRVYNDAQNLLKTIITTNKLQAHGVVAFFPANSVGDDIEVYNENG------EVIEVLRGLRQQAEKEALDKSPYLCLSDFVAPKSSGKKDYIGMFAVTAGHGVDKMCKVYEEKYDDYGIIMVKALADRLAEAFAEELHERVRKEIWGYSREELLEANDLHKIKYQGIRPAPGYPSQPDHTEKDIMWRLLKADKVGITL-TESLAMFPAASVSGLYFAHPKSEYFATGKLQKDQIVDYSARKSVDVSVTEKWLSSALA 1251
BLAST of Methionine synthase vs. TrEMBL
Match: A0A3Q1JSN2 (Methionine synthase OS=Anabas testudineus OX=64144 PE=4 SV=1) HSP 1 Score: 1649.8 bits (4271), Expect = 0.000e+0 Identity = 814/1257 (64.76%), Postives = 1011/1257 (80.43%), Query Frame = 3
Query: 39 IKSVLFSTLRERIMILDGAMGTMIQTYKLEENDFRGEIFKDHPKLLRGNNDLLSLTKPDIVFNIHKEFLDSGADIIETNTFSGTAIAQADYGLEHMVYKLNYESAILARKACDLVSSKSGISRFVAGAIGPTNRTLSISPSVEKPEYRNITFDQLVTAYKEQAHALLDGGVDILLIETIFDTANAKAAVFALFEVFEEAGYEVPVFISGTIVDKSGRNLSGQTTEAFLTSISHIKPICIGLNCALGASDMRPFIETISANTTSFVICYPNAGLPNTFGAYDEKPEYTGEILSQFAKDGLINIVGGCCGTTPAHIAAIKKAVRGYSPRIPPTTLFEDCLVLSGLERFIINPRTTLFVNIGERCNVAGSRRFLRLIKTDKYEEALSIAKEQVENGAQVIDLNMDEGMLEGKLAMTKFINLISSEPDISKVPLCIDSSNFAVIEAGLKCTQGKCIVNSISLKEGELDFYRKLKIIKKFGAAVVIMAFDEQGQAADYDRKIAICCRIYDLLVNKMDFNPNDIIFDLNILTIGTGMEEHNGYGMDFIRATEFVKKNLPHAKVSGGVSNISFSFRGKEVVREAMHSVFLFHAIKAGMDMGIVNAGCLPVYDDIEPRLLELCEDILWNKRQDATDRLLEYAENLLKSDDVGILKTEDAWRSLSVSERLEHSLVKGIDKYIIEDTEEARKC---HVRPLHVIEGPLMRGMSTVGDLFGAGKMFLPQVIKSARVMKRAVGYLIPFMEEEKRLAMEVSGIYSNEPQYVGTMVIATVKGDVHDIGKNIVGVVMGCNNYRVIDLGVMCPSEKILQCALEEKADVIGLSGLITPSLEEMMHVAREMERLGMRTPLLIGGATTSRQHTAVKIAPKYSGPTVHVLDASKSVVVTNSLLDDTXXXXXXXXXXXXXXXXXXXXXXSLAERIYLSIDEARKRKLQLNWSIDHFQSHRPNFLGSKIVENIDINILLPYIDWKPFFDVWQLRGKYPNRGYPKIFNDKDVGKEAQILFSDAQKVLFEIIQYKLLHVNGVIGFYPAHSEGDDILLYDPDSFNVNRKNH-LTTLFGLRQQEEREDPN---YLCISDFIAPIESGCDDYVGMFAVTAGI-GADSLAQKFQDQGDDYNSLMVKALADRLAEASAEYLHHIVRTTLWGYSPNENLTPEDYIKVMYDGIRPAPGYPTQPDHSEQATVWDLLK-PERIGINLHKDSLGMSPAASVSGLYFSHPKSKYFSVGKISKDQVYDYAKRKQISIGESEKRLQSILSYETD 3782
++S L + L++R+M+LDG MGTMIQ +KLEE DFRG+ FKDHP L+GNNDLLS+T+P+I++NIHKE+L +GADIIETNTFS T++AQADYGLEHM Y+LN SA LAR+A D V+ ++G R+VAG++GPTN+TLS+SPSVE+P++RNITFD+LV AY EQ LLDGG D++L+ETIFDTANAKAA+FA+ +FE++ P+FISGTIVD+SGR LSGQT EAF+ S+SH KP+CIGLNCALGA++MRPFIETI +TT+F+ICYPNAGLPNTFG YDE PE T L +FA DGL+NIVGGCCGTTP HI AI +AVR PR P +++DCL+LSGLE F I P T FVNIGERCNVAGS +F RLIKT YEEALSIAK QVE GAQV+D+NMDEGMLEG AMT+F NLI+SEPDI++VPLCIDSSNF+VIEAGLKC QGKCIVNSISLKEGE +F + +K++GAAVV+MAFDE+GQA D DRK+ IC R Y LLVNK+ FNPNDIIFD NILTIGTGMEEHN Y ++F+RAT+ +K+ LP A+VSGG+SN+SFSFRG E +REAMH FL+HAIK GMDMGIVNAG LPVYDDI+ LL LCE+++WN+ ATD+LL YA+N +K +++T D WR SV ERLE++L+KGI+KYI+ED EE R + RPLH+IEGPLM GM VGDLFGAGKMFLPQVIKSARVMK+AV +LIPFME+E+ M +G Y GT+V+ATVKGDVHDIGKNIVGVV+GCNN+RVIDLGVM P +KIL+ A+ +KAD+IGLSGLITPSL+EM++VA+EMERLG++TPLLIGGATTS+ HTAVKIAP+YS P VHVLDAS+SVVV + LLD+T +E+ + ++EEYEEIR++HY+SL +R YLS+ +AR++ L ++W + + RP FLG++I E D+N L+ +IDWKPFFDVWQLRGKYPNRGYPKIFNDK VG EAQ +F DAQ++L ++I L +G++GF+ A S GDDI +Y+ D V R + T GLRQQ ++ + YLC+SDF+AP++SG DY+G+FA AG+ GA L+Q+F+ QGDDY+S+MVKALADRLAEA AE LH VR LWGYS E L D +V Y GIRPAPGYP+QPDH+E+ T+WDL E+ GI+L +SL M PAASVSGLYFS+P++ YF+VGKI+K+QV DYAKRK++S+ E E+ L IL Y+TD
Sbjct: 20 LESELRAVLQKRVMVLDGGMGTMIQHHKLEEEDFRGDEFKDHPLPLKGNNDLLSITQPNIIYNIHKEYLQAGADIIETNTFSSTSVAQADYGLEHMAYRLNKASAELARRAADDVAKQTGCKRYVAGSVGPTNKTLSVSPSVERPDFRNITFDELVEAYSEQVRGLLDGGADLILVETIFDTANAKAALFAIDLLFEKSYERKPIFISGTIVDRSGRTLSGQTGEAFIVSVSHAKPLCIGLNCALGATEMRPFIETIGQSTTAFIICYPNAGLPNTFGGYDETPEVTASNLKEFAMDGLVNIVGGCCGTTPGHIRAISEAVRHCKPRAPVANIYQDCLLLSGLEPFRIGPHTN-FVNIGERCNVAGSLKFARLIKTGNYEEALSIAKMQVEMGAQVLDINMDEGMLEGATAMTRFCNLIASEPDIARVPLCIDSSNFSVIEAGLKCCQGKCIVNSISLKEGEEEFLLRAATVKRYGAAVVVMAFDEEGQATDTDRKVEICTRAYKLLVNKVGFNPNDIIFDPNILTIGTGMEEHNEYAVNFMRATKLIKETLPGARVSGGLSNLSFSFRGMEAIREAMHGAFLYHAIKDGMDMGIVNAGNLPVYDDIDKELLLLCENLIWNRDAGATDKLLAYAQNNVKGGK-KVVQT-DEWREGSVEERLEYALIKGIEKYIVEDVEECRTQVDRYTRPLHIIEGPLMNGMKVVGDLFGAGKMFLPQVIKSARVMKKAVSHLIPFMEKEREEMMASTGSTEELDPYQGTIVLATVKGDVHDIGKNIVGVVLGCNNFRVIDLGVMVPCDKILREAIAQKADIIGLSGLITPSLDEMIYVAKEMERLGIKTPLLIGGATTSKTHTAVKIAPRYSCPVVHVLDASRSVVVCSQLLDETMREEYFDEVKEEYEEIRQDHYDSLMDRQYLSLSQAREKALHIDW-LSQPRPVRPQFLGTRIFECYDLNSLVDFIDWKPFFDVWQLRGKYPNRGYPKIFNDKTVGSEAQRVFDDAQRLLSQMIDSSSLKGHGLVGFWRAQSYGDDINVYE-DDVKVRRDTKPIATFHGLRQQLVKDSSSSEAYLCLSDFVAPVDSGVADYIGLFA--AGVFGAKELSQQFEAQGDDYSSIMVKALADRLAEAFAEELHVRVRKELWGYSSEEALQTSDLHRVRYQGIRPAPGYPSQPDHTEKITMWDLAGVQEKTGISL-TESLAMMPAASVSGLYFSNPQASYFAVGKITKEQVEDYAKRKEMSVEEVERWLAPILGYDTD 1268
BLAST of Methionine synthase vs. TrEMBL
Match: A0A1S3HNR6 (Methionine synthase OS=Lingula unguis OX=7574 GN=LOC106156809 PE=4 SV=1) HSP 1 Score: 1649.41 bits (4270), Expect = 0.000e+0 Identity = 839/1257 (66.75%), Postives = 1011/1257 (80.43%), Query Frame = 3
Query: 36 NIKSVLFSTLRERIMILDGAMGTMIQTYKLEENDFRGEIFKDHPKLLRGNNDLLSLTKPDIVFNIHKEFLDSGADIIETNTFSGTAIAQADYGLEHMVYKLNYESAILARKACDLVSSKSGISRFVAGAIGPTNRTLSISPSVEKPEYRNITFDQLVTAYKEQAHALLDGGVDILLIETIFDTANAKAAVFALFEVFEEAGYEVPVFISGTIVDKSGRNLSGQTTEAFLTSISHIKPICIGLNCALGASDMRPFIETISANTTSFVICYPNAGLPNTFGAYDEKPEYTGEILSQFAKDGLINIVGGCCGTTPAHIAAIKKAVRGYSPRIPPTTLFEDCLVLSGLERFIINPRTTLFVNIGERCNVAGSRRFLRLIKTDKYEEALSIAKEQVENGAQVIDLNMDEGMLEGKLAMTKFINLISSEPDISKVPLCIDSSNFAVIEAGLKCTQGKCIVNSISLKEGELDFYRKLKIIKKFGAAVVIMAFDEQGQAADYDRKIAICCRIYDLLVNKMDFNPNDIIFDLNILTIGTGMEEHNGYGMDFIRATEFVKKNLPHAKVSGGVSNISFSFRGKEVVREAMHSVFLFHAIKAGMDMGIVNAGCLPVYDDIEPRLLELCEDILWNKRQDATDRLLEYAENLLKSDDVGILKTEDAWRSLSVSERLEHSLVKGIDKYIIEDTEEAR---KCHVRPLHVIEGPLMRGMSTVGDLFGAGKMFLPQVIKSARVMKRAVGYLIPFMEEEKRLAMEVSGIYSNEPQYVGTMVIATVKGDVHDIGKNIVGVVMGCNNYRVIDLGVMCPSEKILQCALEEKADVIGLSGLITPSLEEMMHVAREMERLGMRTPLLIGGATTSRQHTAVKIAPKYSGPTVHVLDASKSVVVTNSLLDDTXXXX-XXXXXXXXXXXXXXXXXXSLAERIYLSIDEARKRKLQLNWSIDHFQSHRPNFLGSKIVENIDINILLPYIDWKPFFDVWQLRGKYPNRGYPKIFNDKDVGKEAQILFSDAQKVLFEIIQYKLLHVNGVIGFYPAHSEGDDILLYDPDSFNVNRKNHLTTLFGLRQQEER----EDPNYLCISDFIAPIESGCDDYVGMFAVTAGIGADSLAQKFQDQGDDYNSLMVKALADRLAEASAEYLHHIVRTTLWGYSPNENLTPEDYIKVMYDGIRPAPGYPTQPDHSEQATVWDLLKPERIGINLHKDSLGMSPAASVSGLYFSHPKSKYFSVGKISKDQVYDYAKRKQISIGESEKRLQSILSYETD 3782
+I + + +TL ERIMI DGAMGTMIQ +LEE DFRGE+FKDHPK L+GNNDLLSLT+PD++ IHKE+L++GAD +ETNTFSGT +AQADYGLEH+ Y++N ESA LAR+A D V++++G+ R+VAGA+GPTNRTLSISPSVEKPEYRNITFD+LVTAY EQA LLDGG D+LL+ETIFDTAN+KAA+FA+ +FE+ VP+FISGTIVDKSGR LSGQTTEAF+ S+SH P+C+GLNCALGAS+MRPFIE+I NTT++V+CYPNAGLPNTFG YDE PE E L FA+DGL+NI+GGCCGTTP HI IK+AV+ Y PR PT L E +LSGLE +I P T FVNIGERCNVAGSR+F +LIK ++YEEALSIAK QVENGAQV+D+NMDEGML+G AM+KF+N ISSEPDISKVPLCIDSSNFAVIEAGLKCTQGKCIVNSISLKEGE DF +K K+IKK GAAVV+MAFDE+GQA D +RKIAIC R YD+LV K+ F P DIIFD NILTI TG+EEHN YG+ FI AT +K+ LP A+VSGGVSN SFSFRG + VREAMHSVFL+HAIKAGMDMGIVNAGCLPVYDDI+ LLELCE++LWNK + T++LL YA++L K D + + WR +V ERL + L+KGIDKY++EDTEEAR + R L+VIEGPLM GM TVGDLFGAGKMFLPQVIKSARVMK+AVGYLIPFME+EK M+ +GI Y GT+V+ATVKGDVHDIGKNIVGVV+GCNN++VIDLGVM P EKIL A +EKAD+IGLSGLITPSL+EM+HVA+EMER M+TPLLIGGATTS+QHTAVKI+P+YS P +HVLDASKSVVV ++LLD T++ + E I EEYEEIR+EHYESL ER YLS+++AR++ L+++WS++ P FLG K E D++ L+PYIDWKPFFDVWQLRGKYPNRG+PKIFND VG+EA+ L+++AQ +L +I KLL GV+ FY A+S GDDI LYD + +L TL+GLRQQ E+ EDP YLCISDF+AP E+ DY+GMFAV+ G D + +F+ Q DDY+ +MVKALADRLAEA AE +H VR WGY E L +D ++ Y+GIRPAPGYP+QPDH+E+ T+W L+KP+R+GI L +SL M PAASVSGLYF++PKS YF+VGKI+KDQV DYA RK+ + EK L L+Y TD
Sbjct: 17 DIGAEISATLEERIMIFDGAMGTMIQKNRLEEEDFRGELFKDHPKNLKGNNDLLSLTRPDVIMKIHKEYLEAGADFVETNTFSGTWVAQADYGLEHLAYRINLESAKLARRAADEVTAQTGVRRYVAGALGPTNRTLSISPSVEKPEYRNITFDELVTAYTEQAKGLLDGGADVLLVETIFDTANSKAALFAIETLFEKDYKPVPIFISGTIVDKSGRTLSGQTTEAFVISVSHSNPMCLGLNCALGASEMRPFIESIGKNTTAYVLCYPNAGLPNTFGEYDETPELMAEKLGSFARDGLVNIIGGCCGTTPDHIRVIKEAVQKYPPRKRPTVLREGYTLLSGLEPMLIGPHTN-FVNIGERCNVAGSRKFCKLIKDNQYEEALSIAKLQVENGAQVLDINMDEGMLDGVAAMSKFVNFISSEPDISKVPLCIDSSNFAVIEAGLKCTQGKCIVNSISLKEGEEDFIQKAKVIKKHGAAVVVMAFDEEGQATDTERKIAICQRSYDILVKKVGFYPYDIIFDPNILTIATGIEEHNPYGISFIEATRAIKERLPGARVSGGVSNFSFSFRGMDAVREAMHSVFLYHAIKAGMDMGIVNAGCLPVYDDIKKELLELCENLLWNKDPEGTEKLLTYAQSLGK--DAKKITESEEWRKNTVEERLAYGLIKGIDKYVVEDTEEARANKALYPRTLNVIEGPLMAGMGTVGDLFGAGKMFLPQVIKSARVMKKAVGYLIPFMEKEKEEKMKETGIKDLSDAYNGTVVLATVKGDVHDIGKNIVGVVLGCNNFKVIDLGVMTPCEKILDTATQEKADIIGLSGLITPSLDEMIHVAKEMERRDMKTPLLIGGATTSKQHTAVKISPRYSSPVIHVLDASKSVVVCSNLLDKTENYADYIEEIAEEYEEIREEHYESLKERKYLSLEKARQKSLKIDWSMEP-APVAPTFLGVKTFEEYDLSALIPYIDWKPFFDVWQLRGKYPNRGFPKIFNDPTVGEEAKKLYNEAQAMLKKITDNKLLTARGVVAFYKANSIGDDIELYD------DTGAYLNTLYGLRQQAEKEPGVEDP-YLCISDFVAPKETSIRDYIGMFAVSC-FGVDKMCNEFERQLDDYSIIMVKALADRLAEAFAEEMHERVRKEYWGYCTQETLGAQDLHRIKYEGIRPAPGYPSQPDHTEKITMWKLMKPDRLGIKL-TESLAMEPAASVSGLYFANPKSYYFAVGKINKDQVEDYAGRKKEDVATIEKWLGPCLAYSTD 1260
BLAST of Methionine synthase vs. TrEMBL
Match: A0A3Q1ECF4 (Methionine synthase OS=Acanthochromis polyacanthus OX=80966 PE=4 SV=1) HSP 1 Score: 1639.78 bits (4245), Expect = 0.000e+0 Identity = 805/1255 (64.14%), Postives = 1000/1255 (79.68%), Query Frame = 3
Query: 39 IKSVLFSTLRERIMILDGAMGTMIQTYKLEENDFRGEIFKDHPKLLRGNNDLLSLTKPDIVFNIHKEFLDSGADIIETNTFSGTAIAQADYGLEHMVYKLNYESAILARKACDLVSSKSGISRFVAGAIGPTNRTLSISPSVEKPEYRNITFDQLVTAYKEQAHALLDGGVDILLIETIFDTANAKAAVFALFEVFEEAGYEVPVFISGTIVDKSGRNLSGQTTEAFLTSISHIKPICIGLNCALGASDMRPFIETISANTTSFVICYPNAGLPNTFGAYDEKPEYTGEILSQFAKDGLINIVGGCCGTTPAHIAAIKKAVRGYSPRIPPTTLFEDCLVLSGLERFIINPRTTLFVNIGERCNVAGSRRFLRLIKTDKYEEALSIAKEQVENGAQVIDLNMDEGMLEGKLAMTKFINLISSEPDISKVPLCIDSSNFAVIEAGLKCTQGKCIVNSISLKEGELDFYRKLKIIKKFGAAVVIMAFDEQGQAADYDRKIAICCRIYDLLVNKMDFNPNDIIFDLNILTIGTGMEEHNGYGMDFIRATEFVKKNLPHAKVSGGVSNISFSFRGKEVVREAMHSVFLFHAIKAGMDMGIVNAGCLPVYDDIEPRLLELCEDILWNKRQDATDRLLEYAENLLKSDDVGILKTEDAWRSLSVSERLEHSLVKGIDKYIIEDTEEARKC---HVRPLHVIEGPLMRGMSTVGDLFGAGKMFLPQVIKSARVMKRAVGYLIPFMEEEKRLAMEVSGIYSNEPQYVGTMVIATVKGDVHDIGKNIVGVVMGCNNYRVIDLGVMCPSEKILQCALEEKADVIGLSGLITPSLEEMMHVAREMERLGMRTPLLIGGATTSRQHTAVKIAPKYSGPTVHVLDASKSVVVTNSLLDDTXXXXXXXXXXXXXXXXXXXXXXSLAERIYLSIDEARKRKLQLNWSIDHFQSHRPNFLGSKIVENIDINILLPYIDWKPFFDVWQLRGKYPNRGYPKIFNDKDVGKEAQILFSDAQKVLFEIIQYKLLHVNGVIGFYPAHSEGDDILLYDPDSFNVNRKNHLTTLFGLRQQEEREDPN---YLCISDFIAPIESGCDDYVGMFAVTAGIGADSLAQKFQDQGDDYNSLMVKALADRLAEASAEYLHHIVRTTLWGYSPNENLTPEDYIKVMYDGIRPAPGYPTQPDHSEQATVWDLLK-PERIGINLHKDSLGMSPAASVSGLYFSHPKSKYFSVGKISKDQVYDYAKRKQISIGESEKRLQSILSYETD 3782
++S L + L++RIM+LDGAMGTMIQ ++L+E DFRG FK+HP L+GNND+LS+T+PDI++ IHKE+L++GADIIETNTFS T+IAQADYGLEHM Y LN SA LARKA D V+ ++G R+VAGA+GPTN+TLS+SPSVEKP++RNITFD+LV AY EQ LLDGG DILL+ETIFDTANAKAA+FA+ +FE++ PVFISGTIVD+SGR LSGQT EAF+ S+SH KP+CIGLNCALGA++MRPFIE I +TTSF+ICYPNAGLPNTFG YDE P+ T L F+ GL+NIVGGCCGTTPAHI AI +AVR PR+P ++++ L+L+GLE F I P T FVNIGERCNVAGSR+F +LI YEEALSIAK QVE GAQV+D+NMDEGMLEG AM +F N I+SEPD+++VPLCIDSSNF+VIEAGLKC QGKCIVNSISLKEGE +F + +K++GAAVV+MAFDE+GQA D DRK+ IC R Y+LLV+K+ F+PNDIIFD NILTIGTGMEEHN Y ++FIRAT+ +K+ LP AKVSGG+SN+SFSFRG E +REAMH FL+HAIK GMDMGIVNAG LPVYDDI+ LL LCED++WN+ DAT++LL YA+N +K + +++T D WR SV ERLE++L+KGIDKY++ED EE R + RPLH+IEGPLM GM VGDLFGAGK+FLPQVIKSARVMK+AVG+LIPFME+E+ M S + Y GT+V+ATVKGDVHDIGKNIVGVV+GCNN+RVIDLGVM P ++IL+ A+ +KAD+IGLSGLITPSL+EM+HVA+EMERLGM TPLLIGGATTS+ HTAVKIAP+YS P +HVLDAS+SVVV + LLD+ +E+ E ++EEYEEIR+EHY+SL +R YLS+ +AR++ ++W + + RP FLG+++ ++ D+N LL +IDWKPFFDVWQLRGKYPNRGYPKIFNDK VG EA+ +F DAQ++L I L G++GF+ A S GDDI +Y D+ + T GLRQQ E++ + YLC+SDFIAP++SG DYVG+FAV GA+ L+QKFQ QGDDYNS+MVKALADRLAEA AE LH VR LWGY+ E L D ++ Y GIRPA GYP+QPDH+E+ T+W+L E+ GI L +SL M+PAASVSGLYFS+P++ YF+VGKI+K+QV DYA+RK+ S+ E EK L IL Y+++
Sbjct: 20 LESELRAVLQQRIMVLDGAMGTMIQQHELQEEDFRGSKFKEHPLPLKGNNDILSITQPDIIYKIHKEYLEAGADIIETNTFSSTSIAQADYGLEHMAYCLNKASAELARKAADDVAKQTGCKRYVAGAVGPTNKTLSVSPSVEKPDFRNITFDELVEAYVEQVRGLLDGGADILLVETIFDTANAKAALFAIDLLFEKSNERKPVFISGTIVDRSGRTLSGQTGEAFVVSVSHAKPLCIGLNCALGATEMRPFIEAIGKSTTSFIICYPNAGLPNTFGGYDETPQVTASNLQDFSMSGLVNIVGGCCGTTPAHIRAISEAVRHCKPRLPAADVYQNYLLLAGLEPFRIGPYTN-FVNIGERCNVAGSRKFAKLIMAGNYEEALSIAKAQVEMGAQVLDINMDEGMLEGPTAMARFCNFIASEPDVARVPLCIDSSNFSVIEAGLKCCQGKCIVNSISLKEGEPEFLLRAATVKRYGAAVVVMAFDEEGQATDTDRKVEICTRAYNLLVSKVGFDPNDIIFDPNILTIGTGMEEHNDYAVNFIRATKLIKETLPRAKVSGGLSNLSFSFRGMEAIREAMHGAFLYHAIKDGMDMGIVNAGNLPVYDDIDKELLSLCEDLIWNRDADATEKLLAYAQNNVK-EGKKVVQT-DQWRESSVEERLEYALIKGIDKYVVEDVEECRAQTDRYTRPLHIIEGPLMNGMKVVGDLFGAGKLFLPQVIKSARVMKKAVGHLIPFMEKEREEMMASSSTDTEMDPYQGTIVLATVKGDVHDIGKNIVGVVLGCNNFRVIDLGVMVPCDRILREAVAQKADIIGLSGLITPSLDEMIHVAKEMERLGMTTPLLIGGATTSKTHTAVKIAPRYSSPAIHVLDASRSVVVCSQLLDEAVMEEYFEELKEEYEEIRQEHYDSLKDRRYLSLSQAREKAFHVDW-LSLPRPVRPQFLGTRVFDSYDLNSLLDFIDWKPFFDVWQLRGKYPNRGYPKIFNDKTVGSEARRVFDDAQRLLSHIFDQSSLKGRGLVGFWRAQSVGDDIRVYKDDATVCRDTKPIATFHGLRQQAEKDSHSSEPYLCVSDFIAPVDSGVADYVGVFAVGV-FGAEELSQKFQAQGDDYNSIMVKALADRLAEAFAEELHARVRKELWGYNAEEALQASDLHRIRYQGIRPAAGYPSQPDHTEKTTMWNLAGIQEKTGIGL-TESLAMTPAASVSGLYFSNPQASYFAVGKITKEQVEDYARRKETSVEEVEKWLAPILGYDSE 1268
BLAST of Methionine synthase vs. Ensembl Cavefish
Match: mtr (5-methyltetrahydrofolate-homocysteine methyltransferase [Source:ZFIN;Acc:ZDB-GENE-031001-5]) HSP 1 Score: 1620.91 bits (4196), Expect = 0.000e+0 Identity = 799/1237 (64.59%), Postives = 996/1237 (80.52%), Query Frame = 3
Query: 96 MGTMIQTYKLEENDFRGEIFKDHPKLLRGNNDLLSLTKPDIVFNIHKEFLDSGADIIETNTFSGTAIAQADYGLEHMVYKLNYESAILARKACDLVSSKSGISRFVAGAIGPTNRTLSISPSVEKPEYRNITFDQLVTAYKEQAHALLDGGVDILLIETIFDTANAKAAVFALFEVFEEAGYEVPVFISGTIVDKSGRNLSGQTTEAFLTSISHIKPICIGLNCALGASDMRPFIETISANTTSFVICYPNAGLPNTFGAYDEKPEYTGEILSQFAKDGLINIVGGCCGTTPAHIAAIKKAVRGYSPRIPPTTLFEDCLVLSGLERFIINPRTTLFVNIGERCNVAGSRRFLRLIKTDKYEEALSIAKEQVENGAQVIDLNMDEGMLEGKLAMTKFINLISSEPDISKVPLCIDSSNFAVIEAGLKCTQGKCIVNSISLKEGELDFYRKLKIIKKFGAAVVIMAFDEQGQAADYDRKIAICCRIYDLLVNKMDFNPNDIIFDLNILTIGTGMEEHNGYGMDFIRATEFVKKNLPHAKVSGGVSNISFSFRGKEVVREAMHSVFLFHAIKAGMDMGIVNAGCLPVYDDIEPRLLELCEDILWNKRQDATDRLLEYAENLLKSDDVGILKTEDAWRSLSVSERLEHSLVKGIDKYIIEDTEEARKC---HVRPLHVIEGPLMRGMSTVGDLFGAGKMFLPQVIKSARVMKRAVGYLIPFMEEEKRLAMEVSGIYSNEPQYVGTMVIATVKGDVHDIGKNIVGVVMGCNNYRVIDLGVMCPSEKILQCALEEKADVIGLSGLITPSLEEMMHVAREMERLGMRTPLLIGGATTSRQHTAVKIAPKYSGPTVHVLDASKSVVVTNSLLDDTXXXXXXXXXXXXXXXXXXXXXXSLAERIYLSIDEARKRKLQLNWSIDHFQSHRPNFLGSKIVENIDINILLPYIDWKPFFDVWQLRGKYPNRGYPKIFNDKDVGKEAQILFSDAQKVLFEIIQYKLLHVNGVIGFYPAHSEGDDILLYDPDSFNVNRKNHLTTLFGLRQQEERE----DPNYLCISDFIAPIESGCDDYVGMFAVTAGIGADSLAQKFQDQGDDYNSLMVKALADRLAEASAEYLHHIVRTTLWGYSPNENLTPEDYIKVMYDGIRPAPGYPTQPDHSEQATVWDLLK-PERIGINLHKDSLGMSPAASVSGLYFSHPKSKYFSVGKISKDQVYDYAKRKQISIGESEKRLQSILSYETD 3782
MGTMIQ KLEE DFR + FKDHPK L+GNNDLLS+T+P+++++IHKE+L +GADIIETNTFSGT +AQADYGLE + Y+LN SA +ARKA D V++++G+ R+VAGA+GPTNRTLS+SPSVE+P++RNITFD+LV AY EQ LLDGG DILL+ETIFDTANAKAA+FA+ +FEE+ P+FISGTIVDKSGR LSGQT EAF+ S+SH+KP+CIGLNCALGA++MRPFIE I +T++F+ICYPNAGLPNTFG YDE P+ T + +FA DGL+NIVGGCCGTTP HI AI ++V+ SPR+P +F D ++LSGLE F I P T FVNIGERCNVAGSR+F +LI + YEEALSIAK QVE GAQV+D+NMDEGMLEG AMT+F NLI+SEPDI++VPLCIDSSNFAVIEAGLKC QGKCIVNSISLKEGE +F ++ ++++GAAVVIMAFDE+GQA + D+K+ IC R Y LLV+K+ FNPNDIIFD NILTIGTGMEEHN Y ++FIRAT +K+ LP A+VSGG+SN+SFSFRG E +REAMH FL+HAIK GMDMGIVNAG LPVYDDI+ LL LCE+++WNK +AT++LL+YA+N K +++T D WR +V ERLE++L+KGI+KY++EDTEEAR + RPLHVIEGPLM GM TVGDLFGAGKMFLPQVIKSARVMK+AVGYLIPFME+E+ M SG + Y GT+V+ATVKGDVHDIGKNIVGVV+GCNN+RVIDLGVM P ++IL+ A+E+KADVIGLSGLITPSL+EM+HVA+EM+RL ++TPLLIGGATTS+ HTAVKIAP+YS P +HVLDAS+SVVV + LLD+ ++++ E + EEYE+IR+EHY+SL ER YLS+ +AR + L ++W + RP FLG+++ E D+ L+ +IDWKPFFDVWQLRGKYPNRGYPKIFNDK VG EA+ ++ DA +L +I K L GV+GF+PA S+GDDILL+ + N + T +GLRQQ E++ DP YLC+SDF+AP++SG DYVG+FAV A GA+ L++ F+ +GDDY+S+MVKALADRLAEA AE LH VR LWGYS +L + K+ Y GIRPA GYP+QPDH+E+ T+W L E+ GI L +SL M+PAA+VSGLYFS+PKS YF+VGKI+K+QV DYA+RK+IS+ E+E+ L L Y+TD
Sbjct: 1 MGTMIQQRKLEEEDFRAQEFKDHPKSLKGNNDLLSITQPEVIYSIHKEYLLAGADIIETNTFSGTRVAQADYGLEELAYRLNKASAEVARKAADDVAAQTGVKRYVAGAVGPTNRTLSVSPSVERPDFRNITFDELVEAYSEQVRGLLDGGCDILLVETIFDTANAKAALFAIDLLFEESYEPRPIFISGTIVDKSGRTLSGQTGEAFVISMSHMKPMCIGLNCALGATEMRPFIEAIGKSTSAFIICYPNAGLPNTFGDYDETPQVTASNIKEFAMDGLVNIVGGCCGTTPEHIRAISESVKQCSPRVPQKDIFNDYMLLSGLEPFRIGPYTN-FVNIGERCNVAGSRKFAKLIMSGNYEEALSIAKAQVEMGAQVLDINMDEGMLEGPAAMTRFCNLIASEPDIARVPLCIDSSNFAVIEAGLKCCQGKCIVNSISLKEGEEEFLKRANQVRRYGAAVVIMAFDEEGQATEIDQKVQICTRAYHLLVSKVGFNPNDIIFDPNILTIGTGMEEHNMYAINFIRATSIIKETLPGARVSGGLSNLSFSFRGMEAIREAMHGAFLYHAIKDGMDMGIVNAGNLPVYDDIDKELLVLCENLIWNKDPEATEKLLQYAQNYAKGGK-KVIQT-DEWRKGNVEERLEYALIKGIEKYVVEDTEEARAQTDRYPRPLHVIEGPLMNGMKTVGDLFGAGKMFLPQVIKSARVMKKAVGYLIPFMEKEREEMMAASGETEDTDPYQGTIVLATVKGDVHDIGKNIVGVVLGCNNFRVIDLGVMVPCDRILKEAIEKKADVIGLSGLITPSLDEMIHVAKEMDRLSLKTPLLIGGATTSKTHTAVKIAPRYSSPVIHVLDASRSVVVCSQLLDEGVYEDYFEEVTEEYEDIRQEHYDSLKERHYLSLAQARDKGLHVDW-LAQPAPVRPQFLGTRVFEAYDLRRLVDFIDWKPFFDVWQLRGKYPNRGYPKIFNDKTVGVEARRVYDDAVGLLNRLINSKGLEARGVVGFWPAQSQGDDILLFADNDVTPTSTNPVATFYGLRQQAEKDSASSDP-YLCLSDFVAPLQSGVRDYVGLFAV-AVFGAEKLSRDFERKGDDYSSIMVKALADRLAEAFAEELHARVRRELWGYSNEGDLPASELHKLRYAGIRPAAGYPSQPDHTEKRTMWSLANIQEKTGIGL-TESLAMTPAAAVSGLYFSNPKSSYFAVGKITKEQVEDYARRKEISVSEAERWLAPNLGYDTD 1230
BLAST of Methionine synthase vs. Ensembl Cavefish
Match: zgc:172121 (homocysteine S-methyltransferase YbgG-like [Source:NCBI gene;Acc:103040478]) HSP 1 Score: 62.3882 bits (150), Expect = 7.741e-10 Identity = 74/325 (22.77%), Postives = 141/325 (43.38%), Query Frame = 3
Query: 63 LRERIMILDGAMGTMIQTYKLEENDFRGEIFKDHPKLLRGNNDLLSLTKPDIVFNIHKEFLDSGADIIETNTFSGTAIAQADYGLEHMVYKLNYESAIL------ARKACDLVSSKSGISR----FVAGAIGPTNRTLSISPSVEKPEYRNITFDQLVTAYKEQAHALLDGGVDILLIETIFDTANAKAAVFALFEVFEEAGYEVPVFISGTIVDKSGRNLSGQTTEAFLTSISHIKPICIGLNCALGASDMRPFIETI---SANTTSFVICYPNAG--LPNTFGAYDEKPEYTGEILSQFAKDGLINIVGGCCGTTPAHIAAIK 992
+ + +ILDG + T +LEE RG ++ P + + T P + ++H FL SG+D+I T T+ T + +H+ K +L A+ L ++ + VAG++GP L+ ++ ++L ++ Q L+ D++ +ETI +A V L E ++S + D + + ++A + + + +G+NC+ S + P +E+ A S+V+ YPN+G G ++ +T E+ +++ + G + I GGCC T PA I ++
Sbjct: 1 MTSKPLILDGGLAT-----ELEE---RGFYLQEDPLW----SAKVLYTDPQAIKDVHYRFLQSGSDVITTATYQAT----LEGFFKHLKLKPEQAEELLISGVQIAKDTAALFTTNCTAADRAVPLVAGSVGPYGAFLNDGSEYTGNYQSQMSVEELKDWHRPQVRCLVAAEADLIALETIPCLKEVEALVGLLREF-----PNTKAWMSFSCKDTQCISGGNKFSQAVELAARSTQLVAVGVNCS-APSLVTPLLESAKSQKAPNMSWVV-YPNSGEEWDPKKGWKSKRMSFT-ELSAEWKEQGALWI-GGCCRTGPADITELR 300
BLAST of Methionine synthase vs. Ensembl Sea Lamprey
Match: mtr (5-methyltetrahydrofolate-homocysteine methyltransferase [Source:ZFIN;Acc:ZDB-GENE-031001-5]) HSP 1 Score: 921.768 bits (2381), Expect = 0.000e+0 Identity = 441/727 (60.66%), Postives = 548/727 (75.38%), Query Frame = 3
Query: 36 NIKSVLFSTLRERIMILDGAMGTMIQTYKLEENDFRGEIFKDHPKLLRGNNDLLSLTKPDIVFNIHKEFLDSGADIIETNTFSGTAIAQADYGL--EHMVYKLNYESAILARKACDLVSSKSGISRFVAGAIGPTNRTLSISPSVEKPEYRNITFDQLVTAYKEQAHALLDGGVDILLIETIFDTANAKAAVFALFEVFEEAGYEVPVFISGTIVDKSGRNLSGQTTEAFLTSISHIKPICIGLNCALGASDMRPFIETISANTTSFVICYPNAGLPNTFGAYDEKPEYTGEILSQFAKDGLINIVGGCCGTTPAHIAAIKKAVRGYSPRIPPTTLFEDCLVLSGLERFIINPRTTLFVNIGERCNVAGSRRFLRLIKTDKYEEALSIAKEQVENGAQVIDLNMDEGMLEGKLAMTKFINLISSEPDISKVPLCIDSSNFAVIEAGLKCTQGKCIVNSISLKEGELDFYRKLKIIKKFGAAVVIMAFDEQGQAADYDRKIAICCRIYDLLVNKMDFNPNDIIFDLNILTIGTGMEEHNGYGMDFIRATEFVKKNLPHAKVSGGVSNISFSFRGKEVVREAMHSVFLFHAIKAGMDMGIVNAGCLPVYDDIEPRLLELCEDILWNKRQDATDRLLEYAENLLKSDDVGILKTEDAWRSLSVSERLEHSLVKGIDKYIIEDTEEARKCHV---RPLHVIEGPLMRGMSTVGDLFGAGKMFLPQVIKSAR 2201
+++ +L S LRERIM+LDG MGTMIQ ++L E DFRG+ F++H + L+GNNDLLS+T+PD+++ IH+E+L +GADIIETNTFSGT+IAQADYGL H+ Y+LN SA LA++A V +++G+ RFVAGA+GPTN+TLS+SPSVEKPE+RN+ FD+LV AY EQA LLDGG DI+L+ETIFDTANAKAA+FAL +FE P+F+SGTIVDKSGR LSGQT EAF+ S+SH +P+C+GLNCALGA+DMRPF+E I T+SFVICYPNAGLPNTFG YDE PE T L FA+DGL+NIVGGCCGTTPAHI + + +G P RRF +LI KYEEAL+IAK QVE+GAQ++D+NMDE ML G AM F LI+SEPDI+KVPLCIDSSNFAVIEAGLKC QGKC+VNS+SLKEGE DF K ++++++GAA+V+MAFDE GQA D DRK+ IC R Y LL + FNPNDIIFD NILTI TGMEEHN Y + ++ A +K LP A+VSGG+SN+SFSFRG E +REAMH VFL+HAIK+G++MGIVNAGCLPVYDDI+ LL++CE ++WN+ +ATD+LL+YA+ L + D WRS SV RL+++LVKG++K+++EDTEEAR HV RPLH+IEGPLM GM VGDLFG GKMFLPQV + R
Sbjct: 17 SLRELLPSVLRERIMVLDGGMGTMIQRHQLAEEDFRGDAFREHSRPLQGNNDLLSITRPDVIYGIHREYLLAGADIIETNTFSGTSIAQADYGLGLAHVAYELNKASAELAKRAAKDVGAETGVRRFVAGAMGPTNKTLSVSPSVEKPEFRNLAFDELVQAYMEQARGLLDGGADIMLVETIFDTANAKAALFALQLLFEAEFEPKPIFVSGTIVDKSGRTLSGQTGEAFVISVSHTQPMCLGLNCALGAADMRPFVEAIGKATSSFVICYPNAGLPNTFGDYDETPEITAGHLKSFAQDGLVNIVGGCCGTTPAHIKSPSPSAKGARP----------------------------------------FRRFAKLITAGKYEEALAIAKSQVESGAQILDINMDEAMLNGVEAMAHFCKLIASEPDIAKVPLCIDSSNFAVIEAGLKCCQGKCVVNSVSLKEGEADFLEKARVVRRYGAALVVMAFDEIGQATDADRKLEICSRSYQLLTRLVGFNPNDIIFDPNILTIATGMEEHNLYAITYMEAARRIKATLPGARVSGGLSNLSFSFRGMEAIREAMHGVFLYHAIKSGLEMGIVNAGCLPVYDDIDRDLLDMCEKLIWNRDPEATDKLLQYAQ--LHTKGCKKAVQSDEWRSGSVESRLQYALVKGVEKFVVEDTEEARLDHVKYTRPLHIIEGPLMSGMKVVGDLFGQGKMFLPQVRRGRR 701
BLAST of Methionine synthase vs. Ensembl Yeast
Match: SAM4 (S-adenosylmethionine-homocysteine methyltransferase; functions along with Mht1p in the conversion of S-adenosylmethionine (AdoMet) to methionine to control the methionine/AdoMet ratio; SAM4 has a paralog, YMR321C, that arose from a single-locus duplication [Source:SGD;Acc:S000006194]) HSP 1 Score: 51.9878 bits (123), Expect = 2.582e-7 Identity = 79/337 (23.44%), Postives = 141/337 (41.84%), Query Frame = 3
Query: 69 ERIMILDGAMGTMIQTYKLEENDFRGEIFKDHPKLLRGNNDLLSLTKPDIVFNIHKEFLDSGADIIETNTFSGTAIAQADYGLEHMVYKLNYESAILARKACDLVSSKSGISRFVAGAIGPTN----RTLSISPSVEKPEYRNITFDQLVTAYKEQAHALLDGGVDILLIETIFDTANAKAAVFALFEVFEEAGYEVPVFISGTIVDKSGRNLSGQTTEAFLTSIS----HIKP--ICIGLNCALGASDMRP-FIETISANTTSF-VICYPNAG----------LPNTFGAYDEKPEYTGEILSQFAKDGLINIVGGCCGTTPAHIAAIKKAVRGYS 1013
+++++LDG GT ++ ++ ++ P + S IV + +FL++GA+I+ T T+ + + + E+ + E L + D + G +++ G IGP R + E PE NI F Q E + + +D++ ETI + KA + ++E+ P +I G V + G G T E I I P +G+NC + + P +E++ + ++ YPN+G LPN+ +K ++ Q+ G I+GGCC T+P I I AV+ Y+
Sbjct: 15 KKVLVLDGGQGTELENRGIK---VANPVWSTIPFISESFWSDESSANRKIVKEMFNDFLNAGAEILMTTTYQTSYKSVS----ENTPIRTLSEYNNLLNRIVDFSRNCIGEDKYLIGCIGPWGAHICREFTGDYGAE-PE--NIDFYQYFKPQLENFNK--NDKLDLIGFETIPNIHELKAIL-----SWDESILSRPFYI-GLSVHEHGVLRDGTTMEEIAQVIKDLGDKINPNFSFLGINCV--SFNQSPDILESLHQALPNMALLAYPNSGEVYDTEKKIWLPNS-----DKLNSWDTVVKQYISSG-ARIIGGCCRTSPKDIQEISAAVKKYT 325
BLAST of Methionine synthase vs. Ensembl Nematostella
Match: EDO35691 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7SKT1]) HSP 1 Score: 1461.82 bits (3783), Expect = 0.000e+0 Identity = 756/1247 (60.63%), Postives = 927/1247 (74.34%), Query Frame = 3
Query: 78 MILDGAMGTMIQTYKLEENDFRGEIFKDHPKLLRGNNDLLSLTKPDIVFNIHKEFLDSGADIIETNTFSGTAIAQADYGLEHMVYKLNYESAILARKACDLVSSKSGISRFVAGAIGPTNRTLSISPSVEKPEYRNITFDQLVTAYKEQAHALLDGGVDILLIETIFDTANAKAAVFALFEVFEEAGYEVPVFISGTIVDKSGRNLSGQTTEAFLTSISHIKPICIGLNCALGASDMRPFIETISANTTSFVICYPNAGLPNTFGAYDEKPEYTGEILSQFAKDGLINIVGGCCGTTPAHIAAIKKAVRGYSPRIPPTTLFEDCLVLSGLERFIINPRTTLFVNIGERCNVAGSRRFLRLIKTDKYEEALSIAKEQVENGAQVIDLNMDEGMLEGKLAMTKFINLISSEPDISKVPLCIDSSNFAVIEAGLKCTQGKCIVNSISLKEGELDFYRKLKIIKKFGAAVVIMAFDEQGQAADYDRKIAICCRIYDLLVNKMDFNPNDIIFDLNILTIGTGMEEHNGYGMDFIRATEFVKKNLPHAKVSGGVSNISFSFRGKEVVREAMHSVFLFHAIKAGMDMGIVNAGCLPVYDDIEPRLLELCEDILWNKRQDATDRLLEYAENLLKSDDVGILKTEDAWRSLSVSERLEHSLVKGIDKYIIEDTEEAR---KCHVRPLHVIEGPLMRGMSTVGDLFGAGKMFLPQVIKSARVMKRAVGYLIPFMEEEKRLAMEVSGIYSNEP---QYVGTMVIATVKGDVHDIGKNIVGVVMGCNNYRVIDLGVMCPSEKILQCALEEKADVIGLSGLITPSLEEMMHVAREMERLGMRTPLLIGGATTSRQHTAVKIAPKYSGPTVHVLDASKSVVVTNSLLDDTXXXXXXXXXXXXXXXXXXXXXXSLAERIYLSIDEARKRKLQLNWSIDHFQSHRPNFLGSKIVENIDINILLPYIDWKPFFDVWQLRGKYPNRGYPKIFNDKDVGKEAQILFSDAQKVLFEIIQYKLLHVNGVIGFYPAHSEGDDILLYDPDSFNVNRKNHLTTLF-GLRQQEERE----DPNYLCISDFIAPIESGCDDYVGMFAVTAGIGADSLAQKFQDQGDDYNSLMVKALADRLAEASAEYLHHIVRTTLWGYSPNENLTPEDYIKVMYDGIRPAPGYPTQPDHSEQATVWDLLK-PERIGINLHKDSLGMSPAASVSGLYFSHPKSKYFSVGKISKDQVYDYAKRKQISIGESEKRLQSILSYETD 3782
MI DG MGTMIQ LEE DFRGE FK+HPK L+GNNDLLS+TKPD + +IHK +L++GAD +ETNTFSGT IAQADYGLE Y+LN SA +A++A V++ +G+ +FVAGA+GPTNRTLSISP+VE P +RN+TFD+LV AY EQA LLDGGVD+LL+ETIFDTANAKAA+FA+ ++FE+ VPVF+SGTIVDKSGR LSGQTTE+F+ S+SH P+CIGLNCALGA +MRPFIE + NT ++ ICYPNAGLPNTFG YDE PE + L CCGTTP HI AI +AVR Y PR+ P L D L L GLE INP + LFVNIGERCNVAGSR F +LIK K++ VPLCIDSSNF VIEAGLKC QGKCIVNSISLK GE DF K +IIK++GAAVV+MAFDEQGQAAD +RK+ IC R Y+LLV + F PNDIIFD NILT+ TGMEEHN YG FI+AT +K+ LP A+VSGG+SN SFSFRG + +REAMHSVFL+HAIKAG+DM IVNAG LPVYDDIE LLELCED+LWN+ +AT++LL+ A+++ + D WR +V ERLE +LVKGIDKY+IEDTEEAR + RPL+VIEGPLM+GM VGDLFGAGKMFLPQVIKSARVMK+AVG+LIPFMEEE+++ + G + +Y GT+V+ATVKGDVHDIGKNIVGVV+GCNNYRVIDLGVM EKILQ A+EE+AD+IGLSGLITPSL+EM+HVA+EMER G++ PLLIGGATTSR HTAVKIAP+YS PT+HVLDASKSVVV ++L+D +F E + EEYEEIR++HY+SL ER YLSI++AR++K +++ +D F+ +P FLG K+ E+ D+ ++PYIDWKPFFDVWQLRGKYPNRGYPKIFNDK VG+EA+ +++DAQ +L +++ K L G + F+PA+SEGDD+ ++D D NR +F GLRQQ E+E DP Y CISDFIAP +SG DYVG FAVT +GA++LA+++Q++ DDY+ +MVKALADR+ EA AE LH VR WGY E+L +D ++ Y GIRPA GYP+QPDH+E+ T+W L+ E GI L +SL M PAASVSGLYFSHP+S YF+VGKI +DQ+ +YA RK + EK L S LSY+ +
Sbjct: 1 MIFDGGMGTMIQKLHLEEADFRGEEFKNHPKSLKGNNDLLSITKPDAILDIHKGYLEAGADFVETNTFSGTKIAQADYGLEDAAYRLNRASAEVAKRAAYEVTASTGVEKFVAGAMGPTNRTLSISPTVECPGFRNVTFDELVDAYTEQARGLLDGGVDVLLVETIFDTANAKAALFAIDQLFEKEYSPVPVFVSGTIVDKSGRTLSGQTTESFVISVSHSSPMCIGLNCALGAVEMRPFIEAVGMNTEAYTICYPNAGLPNTFGDYDETPETMAKHLK-----------ARCCGTTPEHIRAIAEAVRPYKPRMRPEDLHSDALSLCGLESMRINP-SVLFVNIGERCNVAGSRMFCKLIKNGKFQ-----------------------------------------------VPLCIDSSNFDVIEAGLKCAQGKCIVNSISLKNGEEDFLDKARIIKRYGAAVVVMAFDEQGQAADCERKVEICTRSYNLLVKEAHFEPNDIIFDPNILTVATGMEEHNNYGKYFIQATRIIKETLPGARVSGGLSNFSFSFRGMDAIREAMHSVFLYHAIKAGLDMAIVNAGALPVYDDIEKNLLELCEDLLWNRDPEATEKLLQLAQSM--GPGAKKVTITDEWRHGNVEERLEFALVKGIDKYVIEDTEEARVNTDRYPRPLNVIEGPLMKGMGVVGDLFGAGKMFLPQVIKSARVMKKAVGHLIPFMEEERQMRLANGGGVGDSSLKNKYNGTIVLATVKGDVHDIGKNIVGVVLGCNNYRVIDLGVMTACEKILQTAIEEEADIIGLSGLITPSLDEMIHVAKEMERQGLKIPLLIGGATTSRTHTAVKIAPRYSEPTIHVLDASKSVVVCSALMDKGARDDFVEEVSEEYEEIREDHYDSLKERRYLSIEKAREKKAFVDF-VD-FRPVKPTFLGIKVFEDYDLEKIIPYIDWKPFFDVWQLRGKYPNRGYPKIFNDKTVGEEARRVYNDAQTMLNNVLRDKTLRAVGELAFFPANSEGDDVYVFDEDD---NRTGEPRAVFCGLRQQAEKEHGVTDP-YYCISDFIAPRDSGIKDYVGCFAVTC-LGAEALAEEYQNELDDYSVIMVKALADRIVEAFAEELHEQVRKHYWGYCGEESLDTKDLHRIRYQGIRPAFGYPSQPDHTEKLTMWGLMNCEESTGIKL-TESLAMDPAASVSGLYFSHPESCYFAVGKICQDQIQEYANRKDKPVQVMEKWLSSALSYDAE 1178
BLAST of Methionine synthase vs. Ensembl Nematostella
Match: EDO25701 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A8DVQ8]) HSP 1 Score: 395.201 bits (1014), Expect = 1.305e-127 Identity = 187/309 (60.52%), Postives = 237/309 (76.70%), Query Frame = 3
Query: 57 STLRERIMILDGAMGTMIQTYKLEENDFRGEIFKDHPKLLRGNNDLLSLTKPDIVFNIHKEFLDSGADIIETNTFSGTAIAQADYGLEHMVYKLNYESAILARKACD-LVSSKSGISRFVAGAIGPTNRTLSISPSVEKPEYRNITFDQLVTAYKEQAHALLDGGVDILLIETIFDTANAKAAVFALFEVFEEAGYEVPVFISGTIVDKSGRNLSGQTTEAFLTSISHIKPICIGLNCALGASDMRPFIETISANTTSFVICYPNAGLPNTFGAYDEKPEYTGEILSQFAKDGLINIVGGCCGTTPAHI 980
S L+ERI++LDGAMGTMIQ + LEE DFR F++H K L+GNNDLLSLT+PDI+ IH + ++GADI ETNTFSGT IAQADY LE VY +N+ SA +AR+ D + + RFVAG++GPTNRT SISP V P YR ITF++LVTAYK+QA+AL+DGGVD+LL+ET+FDT NAKAA+FA+ EV+EE +P+ +SGTI D+SGR L+GQTTEAFL SISH+ + +GLNCALGAS MRP+++ + V +PNAGLPN FG YDE E E + +F ++GL+NI+GGCCGTTPAHI
Sbjct: 6 SILKERILVLDGAMGTMIQRHALEEEDFRRGWFENHHKPLKGNNDLLSLTRPDIIKEIHSLYFEAGADIAETNTFSGTTIAQADYDLEDAVYDINFHSAKIAREVADEFTAREPHKPRFVAGSMGPTNRTASISPDVNDPGYRAITFNELVTAYKQQANALIDGGVDLLLVETVFDTLNAKAALFAIDEVYEERNVNLPIMVSGTITDQSGRTLTGQTTEAFLISISHMNLLTVGLNCALGASMMRPYLQILDKKAPFGVSAHPNAGLPNEFGEYDETAEMMAEQIKEFLEEGLVNIIGGCCGTTPAHI 314
BLAST of Methionine synthase vs. Ensembl Nematostella
Match: EDO25545 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A8DW65]) HSP 1 Score: 169.474 bits (428), Expect = 1.073e-48 Identity = 78/141 (55.32%), Postives = 109/141 (77.30%), Query Frame = 3
Query: 45 SVLFSTLRERIMILDGAMGTMIQTYKLEENDFRGEIFKDHPKLLRGNNDLLSLTKPDIVFNIHKEFLDSGADIIETNTFSGTAIAQADYGLEHMVYKLNYESAILARK-ACDLVSSKSGISRFVAGAIGPTNRTLSISPSV 464
S ++ L++RI++LDGAMGTM+Q +K E DFRGE FK++ L+GNNDLLS+T+P+ V +H+++ +GADI+ETNTFSGT IA ADY LE +VY+LNY+SA +A++ A + + + RFVAG+IGPTNRT S+SP V
Sbjct: 2 SNIYQELQKRILVLDGAMGTMLQEFKFTEEDFRGERFKEYSTPLQGNNDLLSITQPEAVKEVHRKYFAAGADIVETNTFSGTTIAMADYQLEELVYELNYQSAKIAKEVANEFTAKEPHKPRFVAGSIGPTNRTASMSPDV 142
BLAST of Methionine synthase vs. Ensembl Nematostella
Match: EDO48828 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7RIN5]) HSP 1 Score: 68.1662 bits (165), Expect = 7.378e-12 Identity = 78/308 (25.32%), Postives = 134/308 (43.51%), Query Frame = 3
Query: 210 PDIVFNIHKEFLDSGADIIETNTFSGTAIAQADYGLEHMVYKLNYESAILARKACDLVSSKSGISRFVAGAIGPTNRTLSISPSVEKPEYRNITFDQLVTAYKEQAHALLDGGVDILLIETIFDTANAKAAVFALFEVFEEAGYEVPVFISGTIVDKSGRN--LSGQTTEAFLTSISHIKPICIGLNCALGASD-------MRPFIETISANTTSFV----ICYPNAGLPNTFGAYDE-----KPEYTGEILS-QFAKDGL---INIVGGCCGTTPAHIAAIKKAVRGYSPRIPP----TTLFEDCLV 1055
P+ V +H+EFL +GAD+I+ TF+ G + ++++ +ILA++ D G +G++ T +L I K E + +++Q +D G+D+L+ E I A+ V EV +E+G PV ++ I + R+ L G+ + + + I IG+NC M+ I+ T V P+AG P+ F + E +P I + +FA+ + +GGCCG P HI A+ K + R+PP + L+ + LV
Sbjct: 47 PEAVRQLHREFLRAGADVIQAFTFAMQDKPLVSAGYSYKWDEISHAGSILAKEVSD-----EGEFALSSGSLCETG-SLFIKGLASKEEIKQ--------RFRDQVKIFVDTGMDLLIAEYISHVQEAEWMV----EVMKESGK--PVAVTMAISREGDRHGVLPGECAVRLVRAGADI----IGVNCRFDPERSLDTIALMQEAIQREGLKTHWMVQPLGYWCPDAG-PSGFTSIPECTLALEPRVLTRIEAHKFARKAYNMGVRYIGGCCGFEPYHIRALAKELSKERGRLPPGSDKSCLWGEALV 329
BLAST of Methionine synthase vs. Ensembl Nematostella
Match: EDO48830 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7RIN7]) HSP 1 Score: 60.4622 bits (145), Expect = 1.896e-9 Identity = 83/347 (23.92%), Postives = 145/347 (41.79%), Query Frame = 3
Query: 69 ERIMILDGAMGTMIQTYKLEENDF-RGEIFKDHPKLLRGNNDLLSLTKPDIVFNIHKEFLDSGADIIETNTFSGTAIAQADYGLEHMVYKLNYESAILARKACDLVSSKSGISRFVAGAIGPTNRTLSISPSVEKPEYRN--ITFDQLVTAYKEQAHALLDGGVDILLIETIFDTANAKAAVFALFEVFEEAGYEVPVFISGTIVDKSGRN--LSGQTTEAFLTSISHIKPICIGLNCALGASD-------MRPFIETISANTTSFV----ICYPNAGLPNTFGAYDEKPEYTGEIL------SQFAKDGL---INIVGGCCGTTPAHIAAIKKAVRGYSPRIPPTT 1034
E ++I DG M TY LE + + ++ P+ + N P+ V +H+EFL +GAD+I+ TF+ G + ++++ ++LA+ SG F A A G T S+ +R + +++ +++Q +D G+D+++ E I A+ V EV +E+G +P +S I + + L G+ + + + I IG+NC M+ I+ T V P+AG P+ F + E P L +FA+ + +GGCCG P HI A+ + + R PP +
Sbjct: 6 EEVIIGDGGM-----TYALERRGYVKAGVWT--PECVMEN--------PEAVQQLHREFLRAGADVIQAFTFAMQDKPLVSAGYSYKWNEISHAGSLLAKGV-------SGEGEF-ALASGSLCETGSL--------FRKGLASKEEIQQRFRDQVQIFVDTGMDLIIAEYISHVQEAEWMV----EVIKESG--MPTAVSLAISREGDHHGVLPGECALRLVRAGADI----IGVNCRFDPERSLDTIALMQEAIQREGLKTHWMVQPVGYWVPDAG-PSGFTSIPENPLALEPRLMTRIEAHKFARKAYNMGVRYIGGCCGFEPYHIRAVAEELAKERGRFPPGS 310
BLAST of Methionine synthase vs. Ensembl Medaka
Match: mtr (5-methyltetrahydrofolate-homocysteine methyltransferase [Source:NCBI gene;Acc:101155968]) HSP 1 Score: 1617.44 bits (4187), Expect = 0.000e+0 Identity = 799/1260 (63.41%), Postives = 998/1260 (79.21%), Query Frame = 3
Query: 30 RKNIKSVLFSTLRERIMILDGAMGTMIQTYKLEENDFRGEIFKDHPKLLRGNNDLLSLTKPDIVFNIHKEFLDSGADIIETNTFSGTAIAQADYGLEHMVYKLNYESAILARKACDLVSSKSGISRFVAGAIGPTNRTLSISPSVEKPEYRNITFDQLVTAYKEQAHALLDGGVDILLIETIFDTANAKAAVFALFEVFEEAGYEVPVFISGTIVDKSGRNLSGQTTEAFLTSISHIKPICIGLNCALGASDMRPFIETISANTTSFVICYPNAGLPNTFGAYDEKPEYTGEILSQFAKDGLINIVGGCCGTTPAHIAAIKKAVRGYSPRIPPTTLFEDCLVLSGLERFIINPRTTLFVNIGERCNVAGSRRFLRLIKTDKYEEALSIAKEQVENGAQVIDLNMDEGMLEGKLAMTKFINLISSEPDISKVPLCIDSSNFAVIEAGLKCTQGKCIVNSISLKEGELDFYRKLKIIKKFGAAVVIMAFDEQGQAADYDRKIAICCRIYDLLVNKMDFNPNDIIFDLNILTIGTGMEEHNGYGMDFIRATEFVKKNLPHAKVSGGVSNISFSFRGKEVVREAMHSVFLFHAIKAGMDMGIVNAGCLPVYDDIEPRLLELCEDILWNKRQDATDRLLEYAENLLKSDDVGILKTEDAWRSLSVSERLEHSLVKGIDKYIIEDTEEARKC---HVRPLHVIEGPLMRGMSTVGDLFGAGKMFLPQVIKSARVMKRAVGYLIPFMEEEKRLAMEVSGIYSNEPQYVGTMVIATVKGDVHDIGKNIVGVVMGCNNYRVIDLGVMCPSEKILQCALEEKADVIGLSGLITPSLEEMMHVAREMERLGMRTPLLIGGATTSRQHTAVKIAPKYSGPTVHVLDASKSVVVTNSLLDDTXXXXXXXXXXXXXXXXXXXXXXSLAERIYLSIDEARKRKLQLNWSIDHFQSHRPNFLGSKIVENIDINILLPYIDWKPFFDVWQLRGKYPNRGYPKIFNDKDVGKEAQILFSDAQKVLFEIIQYKLLHVNGVIGFYPAHSEGDDILLYDPDSFNVNRKNHLTTLFGLRQQEEREDPN---YLCISDFIAPIESGCDDYVGMFAVTAGI-GADSLAQKFQDQGDDYNSLMVKALADRLAEASAEYLHHIVRTTLWGYSPNENLTPEDYIKVMYDGIRPAPGYPTQPDHSEQATVWDLLK-PERIGINLHKDSLGMSPAASVSGLYFSHPKSKYFSVGKISKDQVYDYAKRKQISIGESEKRLQSILSYETDE 3785
R +++ L + L++RI++LDG MGTMIQ +L+E DFRGE FK HP L GNNDLLS+T+PD+++ IHKE+L +GADI+ETNTFS T+IAQADYGLEHM Y LN SA LARKA D V+ ++G+ RFVAGA+GPTN+TLS+SPSVE+P++RNITFD+LV AY +QA LLDGG DILL+ETIFD+ANAKAA+FA+ +FE+ P+FISGTIVD+SGR LSGQT EAF+ S+SH KP+CIGLNCALGA++MRPFIE I NTT+F+ICYPNAGLPNTFG YDE PE T L FA DGL+N+VGGCCGTTP+HI AI +AV+ PR+PPT ++ED L+LSGLE F I T FVNIGERCNVAGSR+F +LI YEEALSIAK QVE GAQ++D+NMDEGMLEG AM +F N I+SEPDI++VPLCIDSSNFAVIEAGLKC QGKCIVNSISLKEGE +F + +K++GAA+V+MAFDE+GQA + +RKI IC R Y LLVN++ F+PNDIIFD NILTIGTGMEEHN Y ++FI+AT +K+ LP A+VSGG+SN+SFSFRG E VREAMH VFL+HAIK GMDMGIVNAG LPVYDDI+ LL LCE+++WN+ DAT++LL YA+N++K +++T D WR +SV ERLE++LVKGI+KY++ED EE + + RP+H+IEGPLM GM VGDLFGAGKMFLPQVIKSARVMK+AVG+LIPFME+E+ M SG Y GT+++ATVKGDVHDIGKNIVGVV+GCNN+RVIDLGVM P ++IL+ A+ KAD+IGLSGLITPSL+EM++VA+EMERLGMR PLLIGGATTS++HTAVKIAP+YS P +HVLDAS+SVVV + LLD+T +++ E ++EEYEE+R EHY+SL +R YLS+ EAR++ L L+WS P FLG+++ E D++ LL +IDWKPFFDVWQLRGKYPNRG+PKIFNDK VG EA+ LF +AQ +L ++I L G++GF+ A S+GDDI LY+ + T GLRQQ E++ + YLC+SDF+AP++S DYVGMFAV GI GA+ L+Q+F Q DDY+S+MVKALADRLAEA AE LH VR LW YS E L D ++ Y GIRPA GYP+QPDH+E+ T+W+L E+ GI L +SL M+PAASVSGLYFS+P++ YF+VGKI+K+QV DYA+RK++S+ E E+ L IL YE ++
Sbjct: 18 RPQLEAELRALLQQRILVLDGGMGTMIQQQQLDEGDFRGEEFKAHPLPLNGNNDLLSITRPDVIYKIHKEYLLAGADIVETNTFSSTSIAQADYGLEHMAYLLNRRSAELARKAADDVTKQTGVKRFVAGALGPTNKTLSVSPSVERPDFRNITFDELVEAYSDQARGLLDGGADILLVETIFDSANAKAALFAIDLLFEKGYERRPIFISGTIVDRSGRTLSGQTGEAFVVSVSHAKPLCIGLNCALGATEMRPFIEAIGKNTTAFIICYPNAGLPNTFGGYDETPEVTASHLKDFATDGLVNVVGGCCGTTPSHIRAISEAVKHRQPRVPPTAIYEDYLLLSGLEPFKIGSHTN-FVNIGERCNVAGSRKFAKLILAGHYEEALSIAKAQVEMGAQILDINMDEGMLEGPKAMARFCNYIASEPDIARVPLCIDSSNFAVIEAGLKCCQGKCIVNSISLKEGEEEFLLRAATVKRYGAALVVMAFDEEGQATETNRKIQICTRAYTLLVNQVGFDPNDIIFDPNILTIGTGMEEHNNYAVNFIQATRLIKETLPRARVSGGLSNLSFSFRGMEAVREAMHGVFLYHAIKDGMDMGIVNAGSLPVYDDIDKELLLLCENLIWNRDADATEKLLAYAQNIVKGGK-KVVQT-DEWREVSVEERLEYALVKGIEKYVVEDVEECQAQVSRYKRPIHIIEGPLMNGMKMVGDLFGAGKMFLPQVIKSARVMKKAVGHLIPFMEKERLELMAASGSAEETSPYQGTILLATVKGDVHDIGKNIVGVVLGCNNFRVIDLGVMVPCDQILRAAVAHKADIIGLSGLITPSLDEMIYVAKEMERLGMRVPLLIGGATTSKRHTAVKIAPRYSCPVIHVLDASRSVVVCSQLLDETMKEDYFEELKEEYEEVRLEHYDSLKDRRYLSLSEARQKALHLDWS-SMPAPVLPQFLGTRVFECYDLHRLLDFIDWKPFFDVWQLRGKYPNRGFPKIFNDKTVGPEARRLFDEAQLMLSDMIDSGTLKGRGLVGFWRAQSDGDDIHLYNHSERVGVDTRPVATFHGLRQQAEKDGASSEPYLCLSDFVAPVDSNVADYVGMFAV--GIFGAEELSQQFLAQRDDYSSIMVKALADRLAEAFAEELHARVRKELWAYSTEEALQASDLHRLRYQGIRPAAGYPSQPDHTEKITMWNLAAVEEKTGIAL-TESLAMTPAASVSGLYFSNPQASYFAVGKITKEQVEDYARRKEMSVEEVERWLAPILGYEQED 1270
BLAST of Methionine synthase vs. Ensembl Medaka
Match: mtr (5-methyltetrahydrofolate-homocysteine methyltransferase [Source:NCBI gene;Acc:101155968]) HSP 1 Score: 1587.01 bits (4108), Expect = 0.000e+0 Identity = 790/1260 (62.70%), Postives = 988/1260 (78.41%), Query Frame = 3
Query: 30 RKNIKSVLFSTLRERIMILDGAMGTMIQTYKLEENDFRGEIFKDHPKLLRGNNDLLSLTKPDIVFNIHKEFLDSGADIIETNTFSGTAIAQADYGLEHMVYKLNYESAILARKACDLVSSKSGISRFVAGAIGPTNRTLSISPSVEKPEYRNITFDQLVTAYKEQAHALLDGGVDILLIETIFDTANAKAAVFALFEVFEEAGYEVPVFISGTIVDKSGRNLSGQTTEAFLTSISHIKPICIGLNCALGASDMRPFIETISANTTSFVICYPNAGLPNTFGAYDEKPEYTGEILSQFAKDGLINIVGGCCGTTPAHIAAIKKAVRGYSPRIPPTTLFEDCLVLSGLERFIINPRTTLFVNIGERCNVAGSRRFLRLIKTDKYEEALSIAKEQVENGAQVIDLNMDEGMLEGKLAMTKFINLISSEPDISKVPLCIDSSNFAVIEAGLKCTQGKCIVNSISLKEGELDFYRKLKIIKKFGAAVVIMAFDEQGQAADYDRKIAICCRIYDLLVNKMDFNPNDIIFDLNILTIGTGMEEHNGYGMDFIRATEFVKKNLPHAKVSGGVSNISFSFRGKEVVREAMHSVFLFHAIKAGMDMGIVNAGCLPVYDDIEPRLLELCEDILWNKRQDATDRLLEYAENLLKSDDVGILKTEDAWRSLSVSERLEHSLVKGIDKYIIEDTEEARKC---HVRPLHVIEGPLMRGMSTVGDLFGAGKMFLPQVIKSARVMKRAVGYLIPFMEEEKRLAMEVSGIYSNEPQYVGTMVIATVKGDVHDIGKNIVGVVMGCNNYRVIDLGVMCPSEKILQCALEEKADVIGLSGLITPSLEEMMHVAREMERLGMRTPLLIGGATTSRQHTAVKIAPKYSGPTVHVLDASKSVVVTNSLLDDTXXXXXXXXXXXXXXXXXXXXXXSLAERIYLSIDEARKRKLQLNWSIDHFQSHRPNFLGSKIVENIDINILLPYIDWKPFFDVWQLRGKYPNRGYPKIFNDKDVGKEAQILFSDAQKVLFEIIQYKLLHVNGVIGFYPAHSEGDDILLYDPDSFNVNRKNHLTTLFGLRQQEEREDPN---YLCISDFIAPIESGCDDYVGMFAVTAGI-GADSLAQKFQDQGDDYNSLMVKALADRLAEASAEYLHHIVRTTLWGYSPNENLTPEDYIKVMYDGIRPAPGYPTQPDHSEQATVWDLLK-PERIGINLHKDSLGMSPAASVSGLYFSHPKSKYFSVGKISKDQVYDYAKRKQISIGESEKRLQSILSYETDE 3785
R +++ L + L++RI++LDG MGTMIQ +L+E DFRGE FK HP L GNNDLLS+T+PD+++ IHKE+L +GADI+ETNTFS T+IAQADYGLEHMV ++ S L + K RFVAGA+GPTN+TLS+SPSVE+P++RNITFD+LV AY +QA LLDGG DILL+ETIFD+ANAKAA+FA+ +FE+ P+FISGTIVD+SGR LSGQT EAF+ S+SH KP+CIGLNCALGA++MRPFIE I NTT+F+ICYPNAGLPNTFG YDE PE T L FA DGL+N+VGGCCGTTP+HI AI +AV+ PR+PPT ++ED L+LSGLE F I T FVNIGERCNVAGSR+F +LI YEEALSIAK QVE GAQ++D+NMDEGMLEG AM +F N I+SEPDI++VPLCIDSSNFAVIEAGLKC QGKCIVNSISLKEGE +F + +K++GAA+V+MAFDE+GQA + +RKI IC R Y LLVN++ F+PNDIIFD NILTIGTGMEEHN Y ++FI+AT +K+ LP A+VSGG+SN+SFSFRG E VREAMH VFL+HAIK GMDMGIVNAG LPVYDDI+ LL LCE+++WN+ DAT++LL YA+N++K +++T D WR +SV ERLE++LVKGI+KY++ED EE + + RP+H+IEGPLM GM VGDLFGAGKMFLPQVIKSARVMK+AVG+LIPFME+E+ M SG Y GT+++ATVKGDVHDIGKNIVGVV+GCNN+RVIDLGVM P ++IL+ A+ KAD+IGLSGLITPSL+EM++VA+EMERLGMR PLLIGGATTS++HTAVKIAP+YS P +HVLDAS+SVVV + LLD+T +++ E ++EEYEE+R EHY+SL +R YLS+ EAR++ L L+WS P FLG+++ E D++ LL +IDWKPFFDVWQLRGKYPNRG+PKIFNDK VG EA+ LF +AQ +L ++I L G++GF+ A S+GDDI LY+ + T GLRQQ E++ + YLC+SDF+AP++S DYVGMFAV GI GA+ L+Q+F Q DDY+S+MVKALADRLAEA AE LH VR LW YS E L D ++ Y GIRPA GYP+QPDH+E+ T+W+L E+ GI L +SL M+PAASVSGLYFS+P++ YF+VGKI+K+QV DYA+RK++S+ E E+ L IL YE ++
Sbjct: 12 RPQLEAELRALLQQRILVLDGGMGTMIQQQQLDEGDFRGEEFKAHPLPLNGNNDLLSITRPDVIYKIHKEYLLAGADIVETNTFSSTSIAQADYGLEHMVRCTHHSSPRLTNADSLTICVK----RFVAGALGPTNKTLSVSPSVERPDFRNITFDELVEAYSDQARGLLDGGADILLVETIFDSANAKAALFAIDLLFEKGYERRPIFISGTIVDRSGRTLSGQTGEAFVVSVSHAKPLCIGLNCALGATEMRPFIEAIGKNTTAFIICYPNAGLPNTFGGYDETPEVTASHLKDFATDGLVNVVGGCCGTTPSHIRAISEAVKHRQPRVPPTAIYEDYLLLSGLEPFKIGSHTN-FVNIGERCNVAGSRKFAKLILAGHYEEALSIAKAQVEMGAQILDINMDEGMLEGPKAMARFCNYIASEPDIARVPLCIDSSNFAVIEAGLKCCQGKCIVNSISLKEGEEEFLLRAATVKRYGAALVVMAFDEEGQATETNRKIQICTRAYTLLVNQVGFDPNDIIFDPNILTIGTGMEEHNNYAVNFIQATRLIKETLPRARVSGGLSNLSFSFRGMEAVREAMHGVFLYHAIKDGMDMGIVNAGSLPVYDDIDKELLLLCENLIWNRDADATEKLLAYAQNIVKGGK-KVVQT-DEWREVSVEERLEYALVKGIEKYVVEDVEECQAQVSRYKRPIHIIEGPLMNGMKMVGDLFGAGKMFLPQVIKSARVMKKAVGHLIPFMEKERLELMAASGSAEETSPYQGTILLATVKGDVHDIGKNIVGVVLGCNNFRVIDLGVMVPCDQILRAAVAHKADIIGLSGLITPSLDEMIYVAKEMERLGMRVPLLIGGATTSKRHTAVKIAPRYSCPVIHVLDASRSVVVCSQLLDETMKEDYFEELKEEYEEVRLEHYDSLKDRRYLSLSEARQKALHLDWS-SMPAPVLPQFLGTRVFECYDLHRLLDFIDWKPFFDVWQLRGKYPNRGFPKIFNDKTVGPEARRLFDEAQLMLSDMIDSGTLKGRGLVGFWRAQSDGDDIHLYNHSERVGVDTRPVATFHGLRQQAEKDGASSEPYLCLSDFVAPVDSNVADYVGMFAV--GIFGAEELSQQFLAQRDDYSSIMVKALADRLAEAFAEELHARVRKELWAYSTEEALQASDLHRLRYQGIRPAAGYPSQPDHTEKITMWNLAAVEEKTGIAL-TESLAMTPAASVSGLYFSNPQASYFAVGKITKEQVEDYARRKEMSVEEVERWLAPILGYEQED 1260
BLAST of Methionine synthase vs. Ensembl Medaka
Match: zgc:172121 (homocysteine S-methyltransferase [Source:NCBI gene;Acc:101164391]) HSP 1 Score: 70.0922 bits (170), Expect = 3.239e-12 Identity = 82/334 (24.55%), Postives = 147/334 (44.01%), Query Frame = 3
Query: 66 RERIMILDGAMGTMIQTYKLEENDFRGEIFKDHPKLLRGNNDLLSLTKPDIVFNIHKEFLDSGADIIETNTFSGTAIAQADYGLEHMVYKLNYESAILARKACDLVSSKSGISR-------------FVAGAIGPTNRTLSISPSVEKPEYRNITFDQLVTAYKEQAHALLDGGVDILLIETIFDTANAKAAVFALFEVFEEAGYEVPVFISGTIVDKSGRNLSGQTTEAFLTSISHIKPICIGLNCALGASDMRPFIETISANTT---SFVICYPNAGL----PNTFGAYDEKPEYTGEILSQFAKDGLINIVGGCCGTTPAHIAAIKKAVRG 1007
R R +ILDG + T ++ + + +G+ +LL T P + + H FL SGAD+I T T+ + ++ V L + A +A +L+ S ++R VAG+IG L + +T D+L ++ Q LL G D+L ETI A A V L E + + + +S ++ D++ + EA + + + +G+NC + + P +++ S+ + S+V+ YPN+G + A E + E+ ++ K G ++GGCC +PA IA ++K ++G
Sbjct: 13 RNRPLILDGGLATELEAHGAQ---LQGDPLWS-ARLLH--------TNPKAIKDAHHRFLLSGADVITTATYQAS--------VQGFVTHLG----MSAERAKELLMSGVHLAREVVKNFGSGNTGPLVAGSIGSYGAYLHDTSEYTGTFAEKMTVDELKDWHRPQVEGLLAAGADLLAFETIPSIKEADAVVELLREFPDSSAW-----LSFSVKDETRISDGSPFAEAVRVASRSAQLLAVGVNCC-SPTVVEPLLDSASSQLSPDMSWVV-YPNSGWEYDSQQGWQARGESSIWIPELSRRWVKQGAA-LIGGCCCISPAEIAELRKVLKG 314
BLAST of Methionine synthase vs. Ensembl Medaka
Match: zgc:172121 (homocysteine S-methyltransferase [Source:NCBI gene;Acc:101164391]) HSP 1 Score: 52.373 bits (124), Expect = 1.634e-6 Identity = 77/327 (23.55%), Postives = 137/327 (41.90%), Query Frame = 3
Query: 66 RERIMILDGAMGTMIQTYKLEENDFRGEIFKDHPKLLRGNNDLLSLTKPDIVFNIHKEFLDSGADIIETNTFSGTAIAQADYGLEHMVYKLNYESAILARKACDLVSSKSGISR-------------FVAGAIGPTNRTLSISPSVEKPEYRNITFDQLVTAYKEQAHALLDGGVDILLIETIFDTANAKAAVFALFEVFEEAGYEVPVFISGTIVDKSGRNLSGQTTEAFLTSISHIKPICIGLNCALGASDMRPFIETISANTT---SFVICYPNAGL----PNTFGAYDEKPEYTGEILSQFAKDGLINIVGGCCGTTPAHIAA 986
R R +ILDG + T ++ + + +G+ +LL T P + + H FL SGAD+I T T+ + ++ V L + A +A +L+ S ++R VAG+IG L + +T D+L ++ Q LL G D+L ETI A A V L E + + + +S ++ D++ + EA + + + +G+NC + + P +++ S+ + S+V+ YPN+G + A E + E+ ++ K G I C P+ IA+
Sbjct: 13 RNRPLILDGGLATELEAHGAQ---LQGDPLWS-ARLLH--------TNPKAIKDAHHRFLLSGADVITTATYQAS--------VQGFVTHLG----MSAERAKELLMSGVHLAREVVKNFGSGNTGPLVAGSIGSYGAYLHDTSEYTGTFAEKMTVDELKDWHRPQVEGLLAAGADLLAFETIPSIKEADAVVELLREFPDSSAW-----LSFSVKDETRISDGSPFAEAVRVASRSAQLLAVGVNCC-SPTVVEPLLDSASSQLSPDMSWVV-YPNSGWEYDSQQGWQARGESSIWIPELSRRWVKQGAALIGTMSCSPFPSAIAS 308
BLAST of Methionine synthase vs. Planmine SMEST
Match: SMESG000054393.1 (SMESG000054393.1) HSP 1 Score: 2532.29 bits (6562), Expect = 0.000e+0 Identity = 1251/1254 (99.76%), Postives = 1253/1254 (99.92%), Query Frame = 3
Query: 27 MRKNIKSVLFSTLRERIMILDGAMGTMIQTYKLEENDFRGEIFKDHPKLLRGNNDLLSLTKPDIVFNIHKEFLDSGADIIETNTFSGTAIAQADYGLEHMVYKLNYESAILARKACDLVSSKSGISRFVAGAIGPTNRTLSISPSVEKPEYRNITFDQLVTAYKEQAHALLDGGVDILLIETIFDTANAKAAVFALFEVFEEAGYEVPVFISGTIVDKSGRNLSGQTTEAFLTSISHIKPICIGLNCALGASDMRPFIETISANTTSFVICYPNAGLPNTFGAYDEKPEYTGEILSQFAKDGLINIVGGCCGTTPAHIAAIKKAVRGYSPRIPPTTLFEDCLVLSGLERFIINPRTTLFVNIGERCNVAGSRRFLRLIKTDKYEEALSIAKEQVENGAQVIDLNMDEGMLEGKLAMTKFINLISSEPDISKVPLCIDSSNFAVIEAGLKCTQGKCIVNSISLKEGELDFYRKLKIIKKFGAAVVIMAFDEQGQAADYDRKIAICCRIYDLLVNKMDFNPNDIIFDLNILTIGTGMEEHNGYGMDFIRATEFVKKNLPHAKVSGGVSNISFSFRGKEVVREAMHSVFLFHAIKAGMDMGIVNAGCLPVYDDIEPRLLELCEDILWNKRQDATDRLLEYAENLLKSDDVGILKTEDAWRSLSVSERLEHSLVKGIDKYIIEDTEEARKCHVRPLHVIEGPLMRGMSTVGDLFGAGKMFLPQVIKSARVMKRAVGYLIPFMEEEKRLAMEVSGIYSNEPQYVGTMVIATVKGDVHDIGKNIVGVVMGCNNYRVIDLGVMCPSEKILQCALEEKADVIGLSGLITPSLEEMMHVAREMERLGMRTPLLIGGATTSRQHTAVKIAPKYSGPTVHVLDASKSVVVTNSLLDDTXXXXXXXXXXXXXXXXXXXXXXSLAERIYLSIDEARKRKLQLNWSIDHFQSHRPNFLGSKIVENIDINILLPYIDWKPFFDVWQLRGKYPNRGYPKIFNDKDVGKEAQILFSDAQKVLFEIIQYKLLHVNGVIGFYPAHSEGDDILLYDPDSFNVNRKNHLTTLFGLRQQEEREDPNYLCISDFIAPIESGCDDYVGMFAVTAGIGADSLAQKFQDQGDDYNSLMVKALADRLAEASAEYLHHIVRTTLWGYSPNENLTPEDYIKVMYDGIRPAPGYPTQPDHSEQATVWDLLKPERIGINLHKDSLGMSPAASVSGLYFSHPKSKYFSVGKISKDQVYDYAKRKQISIGESEKRLQSILSYETDEY 3788
MRKNIKSVLFSTLRERIMILDGAMGTMIQTYKLEENDFRGEIFKDHPKLLRGNNDLLSLTKPDIVFNIHKEFLDSGADIIETNTFSGTAIAQADYGLEHMVYKLNYESAILARKACDLVSSKSGISRFVAGAIGPTNRTLSISPSVEKPEYRNITFDQLVTAYKEQAHALLDGGVDILLIETIFDTANAKAAVFALFEVFEEAGYEVPVFISGTIVDKSGRNLSGQTTEAFLTSISHIKPICIGLNCALGASDMRPFIETISANTTSFVICYPNAGLPNTFGAYDEKPEYTGEILSQFAKDGLINIVGGCCGTTPAHIAAIKKAVRGYSPRIPPTTLFEDCLVLSGLERFIINPRTTLFVNIGERCNVAGSRRFLRLIKTDKYEEALSIAKEQVENGAQVIDLNMDEGMLEGKLAMTKFINLISSEPDISKVPLCIDSSNFAVIEAGLKCTQGKCIVNSISLKEGELDFYRKLKIIKKFGAAVVIMAFDEQGQAADYDRKIAICCRIYDLLVNKMDFNPNDIIFDLNILTIGTGMEEHNGYGMDFIRATEFVKKNLPHAKVSGGVSNISFSFRGKEVVREAMHSVFLFHAIKAGMDMGIVNAGCLPVYDDIEPRLLELCEDILWNKRQDATDRLLEYAENLLKSDDVGILKTEDAWRSLSVSERLEHSLVKGIDKYIIEDTEEARKCHVRPLHVIEGPLMRGMSTVGDLFGAGKMFLPQVIKSARVMKRAVGYLIPFMEEEKRLAMEVSGIYSNEPQYVGTMVIATVKGDVHDIGKNIVGVVMGCNNYRVIDLGVMCPSEKILQCALEEKADVIGLSGLITPSLEEMMHVAREMERLGMRTPLLIGGATTSRQHTAVKIAPKYSGPTVHVLDASKSVVVTNSLLDDTKHQEFEENIQEEYEEIRKEHYESLAERIYLSIDEARKRKLQLNWSIDHFQSHRPNFLGSKIVENIDINILLPYIDWKPFFDVWQLRGKYPNRGYPKIFNDKDVGKEAQILFSDAQKVLFEIIQYKLLHVNGVIGFYPA+SEGDDIL+YDPDSFNVNRKNHLTTLFGLRQQEEREDPNYLCISDFIAPIESGCDDYVGMFAVTAGIGADSLAQKFQDQGDDYNSLMVKALADRLAEASAEYLHHIVRTTLWGYSPNENLTPEDYIKVMYDGIRPAPGYPTQPDHSEQATVWDLLKPERIGINLHKDSLGMSPAASVSGLYFSHPKSKYFSVGKISKDQV DYAKRKQISIGESEKRLQSILSYETDEY
Sbjct: 1 MRKNIKSVLFSTLRERIMILDGAMGTMIQTYKLEENDFRGEIFKDHPKLLRGNNDLLSLTKPDIVFNIHKEFLDSGADIIETNTFSGTAIAQADYGLEHMVYKLNYESAILARKACDLVSSKSGISRFVAGAIGPTNRTLSISPSVEKPEYRNITFDQLVTAYKEQAHALLDGGVDILLIETIFDTANAKAAVFALFEVFEEAGYEVPVFISGTIVDKSGRNLSGQTTEAFLTSISHIKPICIGLNCALGASDMRPFIETISANTTSFVICYPNAGLPNTFGAYDEKPEYTGEILSQFAKDGLINIVGGCCGTTPAHIAAIKKAVRGYSPRIPPTTLFEDCLVLSGLERFIINPRTTLFVNIGERCNVAGSRRFLRLIKTDKYEEALSIAKEQVENGAQVIDLNMDEGMLEGKLAMTKFINLISSEPDISKVPLCIDSSNFAVIEAGLKCTQGKCIVNSISLKEGELDFYRKLKIIKKFGAAVVIMAFDEQGQAADYDRKIAICCRIYDLLVNKMDFNPNDIIFDLNILTIGTGMEEHNGYGMDFIRATEFVKKNLPHAKVSGGVSNISFSFRGKEVVREAMHSVFLFHAIKAGMDMGIVNAGCLPVYDDIEPRLLELCEDILWNKRQDATDRLLEYAENLLKSDDVGILKTEDAWRSLSVSERLEHSLVKGIDKYIIEDTEEARKCHVRPLHVIEGPLMRGMSTVGDLFGAGKMFLPQVIKSARVMKRAVGYLIPFMEEEKRLAMEVSGIYSNEPQYVGTMVIATVKGDVHDIGKNIVGVVMGCNNYRVIDLGVMCPSEKILQCALEEKADVIGLSGLITPSLEEMMHVAREMERLGMRTPLLIGGATTSRQHTAVKIAPKYSGPTVHVLDASKSVVVTNSLLDDTKHQEFEENIQEEYEEIRKEHYESLAERIYLSIDEARKRKLQLNWSIDHFQSHRPNFLGSKIVENIDINILLPYIDWKPFFDVWQLRGKYPNRGYPKIFNDKDVGKEAQILFSDAQKVLFEIIQYKLLHVNGVIGFYPANSEGDDILIYDPDSFNVNRKNHLTTLFGLRQQEEREDPNYLCISDFIAPIESGCDDYVGMFAVTAGIGADSLAQKFQDQGDDYNSLMVKALADRLAEASAEYLHHIVRTTLWGYSPNENLTPEDYIKVMYDGIRPAPGYPTQPDHSEQATVWDLLKPERIGINLHKDSLGMSPAASVSGLYFSHPKSKYFSVGKISKDQVCDYAKRKQISIGESEKRLQSILSYETDEY 1254 The following BLAST results are available for this feature:
BLAST of Methionine synthase vs. Ensembl Human
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Human e!99) Total hits: 5
BLAST of Methionine synthase vs. Ensembl Celegans
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99) Total hits: 1
BLAST of Methionine synthase vs. Ensembl Fly
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99) Total hits: 5
BLAST of Methionine synthase vs. Ensembl Zebrafish
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99) Total hits: 4
BLAST of Methionine synthase vs. Ensembl Xenopus
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99) Total hits: 5
BLAST of Methionine synthase vs. Ensembl Mouse
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99) Total hits: 2
BLAST of Methionine synthase vs. UniProt/SwissProt
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt) Total hits: 5
BLAST of Methionine synthase vs. TrEMBL
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL) Total hits: 5
BLAST of Methionine synthase vs. Ensembl Cavefish
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99) Total hits: 2
BLAST of Methionine synthase vs. Ensembl Sea Lamprey
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99) Total hits: 1
BLAST of Methionine synthase vs. Ensembl Yeast
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46) Total hits: 1
BLAST of Methionine synthase vs. Ensembl Nematostella
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46) Total hits: 5
BLAST of Methionine synthase vs. Ensembl Medaka
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99) Total hits: 4
BLAST of Methionine synthase vs. Planmine SMEST
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST) Total hits: 1
Analyses
This transcript is derived from or has results from the following analyses Sequences
The following sequences are available for this feature:
transcript sequence >SMED30012817 ID=SMED30012817|Name=Methionine synthase|organism=Schmidtea mediterranea sexual|type=transcript|length=3851bpback to top protein sequence of SMED30012817-orf-1 >SMED30012817-orf-1 ID=SMED30012817-orf-1|Name=SMED30012817-orf-1|organism=Schmidtea mediterranea sexual|type=polypeptide|length=1255bp MRKNIKSVLFSTLRERIMILDGAMGTMIQTYKLEENDFRGEIFKDHPKLLback to top Annotated Terms
The following terms have been associated with this transcript:
InterPro
Analysis Name: Schmidtea mediteranean smed_20140614 Interproscan
Date Performed: 2020-05-01
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