Rho guanine nucleotide exchange factor 38
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Overview
Neoblast Clusters
Zeng et. al., 2018▻ Overview▻ Neoblast Population▻ Sub-lethal Irradiated Surviving X1 and X2 Cell Population
Overview
Single cell RNA-seq of pluripotent neoblasts and its early progeniesWe isolated X1 neoblasts cells enriched in high piwi-1 expression (Neoblast Population), and profiled ∼7,614 individual cells via scRNA-seq. Unsupervised analyses uncovered 12 distinct classes from 7,088 high-quality cells. We designated these classes Nb1 to Nb12 and ordered them based on high (Nb1) to low (Nb12) piwi-1 expression levels. We further defined groups of genes that best classified the cells parsed into 12 distinct cell clusters to generate a scaled expression heat map of discriminative gene sets for each cluster. Expression of each cluster’s gene signatures was validated using multiplex fluorescence in situ hybridization (FISH) co-stained with piwi-1 and largely confirmed the cell clusters revealed by scRNA-seq.We also tested sub-lethal irradiation exposure. To profile rare pluripotent stem cells (PSCs) and avoid interference from immediate progenitor cells, we determined a time point after sub-lethal irradiation (7 DPI) with minimal piwi-1+ cells, followed by isolation and single-cell RNA-seq of 1,200 individual cells derived from X1 (Piwi-1 high) and X2 (Piwi-1 low) cell populations (Sub-lethal Irradiated Surviving X1 and X2 Cell Population)Explore this single cell expression dataset with our NB Cluster Shiny App
Neoblast Population
Sub-lethal Irradiated Surviving X1 and X2 Cell Population
Embryonic Expression
Davies et. al., 2017
Hover the mouse over a column in the graph to view average RPKM values per sample. Embryonic Stages: Y: yolk. S2-S8: Stages 2-8. C4: asexual adult. SX: virgin, sexually mature adult. back to top Anatomical Expression
PAGE et. al., 2020SMED30012806 has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGEPAGE Curations: 4
Homology
BLAST of Rho guanine nucleotide exchange factor 38 vs. Ensembl Human
Match: DNMBP (dynamin binding protein [Source:HGNC Symbol;Acc:HGNC:30373]) HSP 1 Score: 154.451 bits (389), Expect = 1.626e-37 Identity = 160/594 (26.94%), Postives = 280/594 (47.14%), Query Frame = 3
Query: 1461 EKKMQKRSXXXXXXXXXXXXXXQDLKITLEAFDKNLIPTKIPDQDFHLLFGDLKSVIAVAEEFLSKLSANMEDGLDKIAVGSVFLQSVSSFEEVYKEYCVNYDRKLDLINKKSKASNVTDFVSDGLNRLNDL-GVFAST----LDMMLVKPLQRFLKYPLFLKTIIENTLPDHPD---INDLIAASSEFDVLAQKINEKKRFEEL----RQITFDR-TEKWHMRTIHAIQKKPKRV---IVSISG-AVQNEDTEYQEIVIKFKELKKCISFFIETVFILRDNLKEILNLYSAITDDFTSIIKSNFGSQLHFYLVACKRGETDY--FKKYYTVANKTCIL------DSLVVNPLNKLLELFSGPALLIKKRQSKYIDYLAMKQRCD---DKETSRVQIDKLDQLRNQYLAINNTLKHELPILISKSSVIFNECIGNYLQLSTSTLQSNILSLKNLIEGDQLSTEEEQRNCRNHQNEILAFLQRDLLSFNPQYRNSINKGDXXXXXXXXXXXXXXXXXXVYN-QTETDVIKLREKFEPENLARVKKDFVPTKPHQIHICAGTLVGILKRCNPQGHSTSWLVEVCPKRTGFVPRSYL 3155
++ ++KR+K+IEE+L+TE+ +I+DL++ +E + ++P+ DF LFG+++ VI V+++ L+ L + D AVG VFL E YK YC N+D + L+ K + + D L L L + T L L+KP+QR ++YPL L ++ +T HPD + + + A E +V INE KR ++L R+ D EK IH+I KK RV + ++G A Q +D ++E F+ ++ I FI + + +++E SA ++ + V +RG D F++ + + + LV++PLN+LL +F+GP L++KR K +D+ +R + DK+T +++L RN Y A+N L ELP + +F C+ Y + + + LK L+ +++ E H+ Q + +F P+ + K + L Y Q+E L ++ PE L + +++F + + + G LVG++K+ +P G WL++ + GFV S+L
Sbjct: 67 QRMLEKRAKVIEELLQTERDYIRDLEMCIERIMVPMQQAQVPNIDFEGLFGNMQMVIKVSKQLLAAL--EISD-----AVGPVFLGHRDELEGTYKIYCQNHDEAIALLEIYEKDEKIQKHLQDSLADLKSLYNEWGCTNYINLGSFLIKPVQRVMRYPLLLMELLNSTPESHPDKVPLTNAVLAVKEINV---NINEYKRRKDLVLKYRKGDEDSLMEKISKLNIHSIIKKSNRVSSHLKHLTGFAPQIKDEVFEETEKNFRMQERLIKSFIRDLSLYLQHIRE-----SACVKVVAAV---------SMWDVCMERGHRDLEQFERVHRYISDQLFTNFKERTERLVISPLNQLLSMFTGPHKLVQKRFDKLLDFYNCTERAEKLKDKKT----LEELQSARNNYEALNAQLLDELPKFHQYAQGLFTNCVHGYAEAHCDFVHQALEQLKPLLSLLKVAGREGNLIAIFHEEHSRVLQQLQVFTFFPESLPATKKPFERKTIDRQSARKPLLGLPSYMLQSEELRASLLARYPPEKLFQAERNFNAAQDLDVSLLEGDLVGVIKKKDPMGSQNRWLIDNGVTK-GFVYSSFL 631
BLAST of Rho guanine nucleotide exchange factor 38 vs. Ensembl Human
Match: DNMBP (dynamin binding protein [Source:HGNC Symbol;Acc:HGNC:30373]) HSP 1 Score: 154.836 bits (390), Expect = 3.721e-37 Identity = 158/596 (26.51%), Postives = 281/596 (47.15%), Query Frame = 3
Query: 1461 EKKMQKRSXXXXXXXXXXXXXXQDLKITLEAFDKNLIPTKIPDQDFHLLFGDLKSVIAVAEEFLSKLSANMEDGLDKIAVGSVFLQSVSSFEEVYKEYCVNYDRKLDLINKKSKASNVTDFVSDGLNRLNDL-GVFAST----LDMMLVKPLQRFLKYPLFLKTIIENTLPDHPD---INDLIAASSEFDVLAQKINEKKRFEEL----RQITFDR-TEKWHMRTIHAIQKKPKRV---IVSISG-AVQNEDTEYQEIVIKFKELKKCISFFIETVFILRDNLKE--ILNLYSAITDDFTSIIKSNFGSQLHFYLVACKRGETDY--FKKYYTVANKTCIL------DSLVVNPLNKLLELFSGPALLIKKRQSKYIDYLAMKQRCD---DKETSRVQIDKLDQLRNQYLAINNTLKHELPILISKSSVIFNECIGNYLQLSTSTLQSNILSLKNLIEGDQLSTEEEQRNCRNHQNEILAFLQRDLLSFNPQYRNSINKGDXXXXXXXXXXXXXXXXXXVYN-QTETDVIKLREKFEPENLARVKKDFVPTKPHQIHICAGTLVGILKRCNPQGHSTSWLVEVCPKRTGFVPRSYL 3155
++ ++KR+K+IEE+L+TE+ +I+DL++ +E + ++P+ DF LFG+++ VI V+++ L+ L + AVG VFL E YK YC N+D + L+ K + + D L L L + T L L+KP+QR ++YPL L ++ +T HPD + + + A E +V INE KR ++L R+ D EK IH+I KK RV + ++G A Q +D ++E F+ ++ I FI + + +++E + + +A++ + V +RG D F++ + + + LV++PLN+LL +F+GP L++KR K +D+ +R + DK+T +++L RN Y A+N L ELP + +F C+ Y + + + LK L+ +++ E H+ Q + +F P+ + K + L Y Q+E L ++ PE L + +++F + + + G LVG++K+ +P G WL++ + GFV S+L
Sbjct: 779 QRMLEKRAKVIEELLQTERDYIRDLEMCIERIMVPMQQAQVPNIDFEGLFGNMQMVIKVSKQLLAALEIS-------DAVGPVFLGHRDELEGTYKIYCQNHDEAIALLEIYEKDEKIQKHLQDSLADLKSLYNEWGCTNYINLGSFLIKPVQRVMRYPLLLMELLNSTPESHPDKVPLTNAVLAVKEINV---NINEYKRRKDLVLKYRKGDEDSLMEKISKLNIHSIIKKSNRVSSHLKHLTGFAPQIKDEVFEETEKNFRMQERLIKSFIRDLSLYLQHIRESACVKVVAAVS----------------MWDVCMERGHRDLEQFERVHRYISDQLFTNFKERTERLVISPLNQLLSMFTGPHKLVQKRFDKLLDFYNCTERAEKLKDKKT----LEELQSARNNYEALNAQLLDELPKFHQYAQGLFTNCVHGYAEAHCDFVHQALEQLKPLLSLLKVAGREGNLIAIFHEEHSRVLQQLQVFTFFPESLPATKKPFERKTIDRQSARKPLLGLPSYMLQSEELRASLLARYPPEKLFQAERNFNAAQDLDVSLLEGDLVGVIKKKDPMGSQNRWLIDNGVTK-GFVYSSFL 1343
BLAST of Rho guanine nucleotide exchange factor 38 vs. Ensembl Human
Match: DNMBP (dynamin binding protein [Source:HGNC Symbol;Acc:HGNC:30373]) HSP 1 Score: 152.91 bits (385), Expect = 9.891e-37 Identity = 158/596 (26.51%), Postives = 281/596 (47.15%), Query Frame = 3
Query: 1461 EKKMQKRSXXXXXXXXXXXXXXQDLKITLEAFDKNLIPTKIPDQDFHLLFGDLKSVIAVAEEFLSKLSANMEDGLDKIAVGSVFLQSVSSFEEVYKEYCVNYDRKLDLINKKSKASNVTDFVSDGLNRLNDL-GVFAST----LDMMLVKPLQRFLKYPLFLKTIIENTLPDHPD---INDLIAASSEFDVLAQKINEKKRFEEL----RQITFDR-TEKWHMRTIHAIQKKPKRV---IVSISG-AVQNEDTEYQEIVIKFKELKKCISFFIETVFILRDNLKE--ILNLYSAITDDFTSIIKSNFGSQLHFYLVACKRGETDY--FKKYYTVANKTCIL------DSLVVNPLNKLLELFSGPALLIKKRQSKYIDYLAMKQRCD---DKETSRVQIDKLDQLRNQYLAINNTLKHELPILISKSSVIFNECIGNYLQLSTSTLQSNILSLKNLIEGDQLSTEEEQRNCRNHQNEILAFLQRDLLSFNPQYRNSINKGDXXXXXXXXXXXXXXXXXXVYN-QTETDVIKLREKFEPENLARVKKDFVPTKPHQIHICAGTLVGILKRCNPQGHSTSWLVEVCPKRTGFVPRSYL 3155
++ ++KR+K+IEE+L+TE+ +I+DL++ +E + ++P+ DF LFG+++ VI V+++ L+ L + AVG VFL E YK YC N+D + L+ K + + D L L L + T L L+KP+QR ++YPL L ++ +T HPD + + + A E +V INE KR ++L R+ D EK IH+I KK RV + ++G A Q +D ++E F+ ++ I FI + + +++E + + +A++ + V +RG D F++ + + + LV++PLN+LL +F+GP L++KR K +D+ +R + DK+T +++L RN Y A+N L ELP + +F C+ Y + + + LK L+ +++ E H+ Q + +F P+ + K + L Y Q+E L ++ PE L + +++F + + + G LVG++K+ +P G WL++ + GFV S+L
Sbjct: 411 QRMLEKRAKVIEELLQTERDYIRDLEMCIERIMVPMQQAQVPNIDFEGLFGNMQMVIKVSKQLLAALEIS-------DAVGPVFLGHRDELEGTYKIYCQNHDEAIALLEIYEKDEKIQKHLQDSLADLKSLYNEWGCTNYINLGSFLIKPVQRVMRYPLLLMELLNSTPESHPDKVPLTNAVLAVKEINV---NINEYKRRKDLVLKYRKGDEDSLMEKISKLNIHSIIKKSNRVSSHLKHLTGFAPQIKDEVFEETEKNFRMQERLIKSFIRDLSLYLQHIRESACVKVVAAVS----------------MWDVCMERGHRDLEQFERVHRYISDQLFTNFKERTERLVISPLNQLLSMFTGPHKLVQKRFDKLLDFYNCTERAEKLKDKKT----LEELQSARNNYEALNAQLLDELPKFHQYAQGLFTNCVHGYAEAHCDFVHQALEQLKPLLSLLKVAGREGNLIAIFHEEHSRVLQQLQVFTFFPESLPATKKPFERKTIDRQSARKPLLGLPSYMLQSEELRASLLARYPPEKLFQAERNFNAAQDLDVSLLEGDLVGVIKKKDPMGSQNRWLIDNGVTK-GFVYSSFL 975
BLAST of Rho guanine nucleotide exchange factor 38 vs. Ensembl Human
Match: ARHGEF38 (Rho guanine nucleotide exchange factor 38 [Source:HGNC Symbol;Acc:HGNC:25968]) HSP 1 Score: 137.117 bits (344), Expect = 3.831e-32 Identity = 190/753 (25.23%), Postives = 331/753 (43.96%), Query Frame = 3
Query: 1458 LEKKMQKRSXXXXXXXXXXXXXXQDLKITLEAFDKNLIPTKIPDQDFHLLFGDLKSVIAVAEEFLSKLSANMEDGLDKIAV-GSVFLQSVSSFEEVYKEYCVNYDRKLDLINKKSKASNVTDFVSDGLNRLNDLGVFAST---LDM--MLVKPLQRFLKYPLFLKTIIENTLPDHPD---INDLIAASSEFDVLAQKINEKKRFEEL----RQITFDRT--EKWHMRTIHAIQKKPKRVI----VSISGAVQNEDTEYQEIVIKFKELKKCISFFIETVFILRDNLKEILNLYSAITDDFTSIIKSNFGSQLHFYLVACKRGETDYFKKYYTVANKTCI-----LDSLVVNPLNKLLELFSGPALLIKKRQSKYIDYLAMKQRCDDKETSRVQIDKLDQLRNQYLAINNTLKHELPILISKSSVIFNECIGNYLQL----------STSTLQSNILSLKNLIE-GDQLSTEEEQRNCRNHQNEILAFLQRDLLSFNPQYRNSINKGDXXXXXXXXXXXXXXXXXXVYNQTETDVIKLREKFEPENLARVKKDFVPTKPHQIHICAGTLVGILKRCNPQGHSTSWLVEVCPKRTGFVPRSYLT-LSPFAANKVD---------------LIGSKVISGN--ATYLNNRHSITADSSFDLMQFSPNNHD-DTLRQISMVEISPVKTRPRAFSTANIIRIALFPHQSRGESEISMQKNDQLEILESPDKSNSRNWSLAKNLRTGAQGYVPTNYLSK 3554
+++ M KR KII+E+++TEK ++ DL++ + + L K D LF +++SV ++ + LS L D + V G VFLQ E++YK YC ++D ++ K + + +S + L + + LDM +++KP+QR +KYPL L + +T P HPD ++D AA + +V INE KR ++L ++ D + +K IH+I KK KRV + G Q +D + F+ L+K + ++ + + ++++ + L D I + K E DY + N +C L L++ PL+ LL LF GP LI+KR K +D + QR +E+ D + +Y A+N L EL + I C+ +++ L + STL L + ++ E +Q+ E + NC + F++R L SF + I + +QT+ KL + E L + K+ T+ + I++ G LV ++++ +P G ++ WLV+ + G+V S+L +P KVD + S+ S + T ++ ++ S +F N D D+ +++ I A+ Q+R + E+S+Q+ ++ IL D S ++ W LA+ G +GYVP NYL K
Sbjct: 88 MKRMMAKREKIIKELIQTEKDYLNDLELCVREVVQPLRNKKTDRLDVDSLFSNIESVHQISAKLLSLLEEATTDVEPAMQVIGEVFLQIKGPLEDIYKIYCYHHDEAHSILESYEKEEELKEHLSHCIQSLKKIYMQEGKPNLLDMGSLMIKPIQRVMKYPLLLCELRNSTPPSHPDYRALDDAFAAVKDINV---NINELKRRKDLVLKYKKNDEDESLKDKLSKLNIHSISKKSKRVTNHLKILTRGESQVKDNTFNREEKLFRALEKTVRLCVKNISLCLQHIQDAMPLALQSVMDLQEISYN-------------KDDEMDYSETLSNALN-SCHDFASHLQRLILTPLSALLSLFPGPHKLIQKRYDKLLDCNSYLQRSTGEES--------DLAKKEYEALNAQLVEELQAFNQAARKILLNCLCSFITLLRDLMLVAQQAYSTLVPMPLLVSSISEIQNQVLEEIQNLNCVKENSA--TFIERKL-SFEKKKPVQI-------------------LPEMPHQTDIHRSKLLSTYSAEELYQAKRKCNATQEYDINLLEGDLVAVIEQKDPLGSTSRWLVDTGNVK-GYVYSSFLKPYNPAKMQKVDAENRFCDDDFENISLFVSSRPASDSVTGTSESSIGDSSSSLSGTCGKFETNGTDVDSFQEVD-----------------EQIFYAVHAFQARSDHELSLQEYQRVHILRFCDLSGNKEWWLAEA--QGQKGYVPANYLGK 773
BLAST of Rho guanine nucleotide exchange factor 38 vs. Ensembl Human
Match: ARHGEF37 (Rho guanine nucleotide exchange factor 37 [Source:HGNC Symbol;Acc:HGNC:34430]) HSP 1 Score: 114.775 bits (286), Expect = 2.635e-25 Identity = 138/550 (25.09%), Postives = 230/550 (41.82%), Query Frame = 3
Query: 1578 KIPDQDFHLLFGDLKSVIAVAEEFLSKLSANMEDGLDKIA-VGSVFLQSVSSFEEVYKEYCVNYDRKLDLINKKSKASNVTDFVSDGLNRLNDLGVFASTLDMMLVKPLQRFLKYPLFLKTIIENTLPDHPDINDLIAASSEFDVLAQKINEKKRFEELRQITFDRTEKWHMR------TIHAIQKKPKR---VIVSISGAV-QNEDTEYQEIVIKFKELKKCISFFIETVFILRDNLKEILNL----YSAITDDFTSIIKSNFGSQLHFYLVACKRGETDYFKKYYTVANKTCILDSLVVNPLNKLLELFSGPALLIKKRQSKYIDYLAMKQRCDDK--ETSRVQIDKLDQLRNQYLAINNTLKHELPILISKSSVIFNECIGNYL---QLSTSTLQSNILSLKNLIEGDQLSTEEEQRNCRNHQNEILAF--LQRDLLSFNPQYRNSINKGDXXXXXXXXXXXXXXXXXXVYNQTETDVIKLREKFEPENLARVKKDFVPTKPHQIHICAGTLVGILKRCNPQGHSTSWLVEVCPKRTGFVPRSYLTL 3161
++P D +LF ++ +I V FL L +++ VG++FL+ E+VYK YC +YD+ L L++ K + + G+ +S L +LV PLQR +YPL L+ I+ENT+PD L A S + INE K +E+ + + E+ +R H + KK R ++ +G + + ED E+ ++ +F+ + C++ V DNL+ L Y+ + ++ N LH + F K+ L+ LV PL L + GP LIKKR K +D+ +R ++K E V + + R+ Y A+N+ L ELP FN+ + +L + TLQ ++ K +++ E +H AF L D L S + + +E V L ++ P L +V + T + + G +V IL+ + +G+S WLV+ R G+VP L L
Sbjct: 62 QLPQGDLDVLFSNIDDIIKVNSRFLHDLQETASKEEEQVQLVGNIFLEFQEELEQVYKVYCASYDQALLLVDTYRKEPELQRHI-QGIVEAVVPQAGSSGLSFLLVIPLQRITRYPLLLQKILENTVPDASAYPVLQRAVSALQDVNTNINEYKMRKEVAS-KYTKVEQLTLRERLARINTHTLSKKTTRLSQLLKQEAGLIPRTEDKEFDDLEERFQWVSLCVTELKNNVAAYLDNLQAFLYFRPHEYNLDIPEGPAVQYCNLARDLHL----------EAFLKFKQR------LEGLVWQPLCSLAKALLGPQNLIKKRLDKLLDF----ERVEEKLLEVGSVTYQE-EAARHTYQALNSLLVAELP--------QFNQLVMQWLGQIMCTFVTLQRDL--AKQVLQ----RAEGSMAQLPHHHVPEPAFRKLVEDALGRTSNQLRSFQE-------TFEKVQPPPTTQPLLPGSERQVQALLSRYGPGKLYQVTSNISGTGTLDLTLPRGQIVAILQNKDTKGNSGRWLVDTGGHR-GYVPAGKLQL 566
BLAST of Rho guanine nucleotide exchange factor 38 vs. Ensembl Celegans
Match: Y37A1B.17 (pep chromosome:WBcel235:IV:13964367:13979847:-1 gene:WBGene00044989.1 transcript:Y37A1B.17a.1 gene_biotype:protein_coding transcript_biotype:protein_coding gene_symbol:Y37A1B.17) HSP 1 Score: 66.2402 bits (160), Expect = 1.634e-10 Identity = 83/326 (25.46%), Postives = 134/326 (41.10%), Query Frame = 3
Query: 1698 VGSVFLQSVSSFEEVYKEYCVNYDRKLDLINKKSKASNVTDFVSDGLNRLNDLGVFASTLDMMLVKPLQRFLKYPLFLKTIIENTLPDHPDINDLIAASSEFDVLAQKINEKKRFEELRQ--ITFDRTEKWHM---RTIHAIQKKPKRVIVSISGAVQN----EDTEYQEIVIKFKELKKCISFFIETVFILRDNL---KEILNLYSAITDDFTSIIKSNFGSQLHFYLVACKRGETDYFKKYYTVANKTCILDSLVVNPLNKLLELFSGPALLIKKRQSKYIDYLAMKQRCDDKETSRVQIDKLD--QLRNQYLAINNTLKHELP 2633
+G+ FLQ F + Y Y N + L N + + D + R+ + G + +P+QR KYPLFL I++ T H D L A + L QK+NE KR +EL Q ++ D+ M T H+++KK R + ++ DT++ +V + ++ + F + I R + +L + + S QL + A K + + AN I D +V L S P LIKKR K +DY A + T + K D +++ Y A+N +K +LP
Sbjct: 535 IGACFLQLRKPFAQTYGFYFRNIEHINALTNSAKHEKTMESALQDIVKRMRESGSVVIDGPTAVSRPIQRATKYPLFLNEIVKLTPLVHTDHPKLTEAIKQMSNLGQKMNESKRRKELTQKYMSDDKQTFGEMLSKMTFHSLKKKSNRFTYRMGSSLGVVKLLRDTDFDRLVCELDSAERRLVRFNYMMVIYRKKMFHETRVLMHKKVVEPRKKHLSSSEIDLQLQPFNHA--------IKTWASEAN-VRIRDEIV-------KALRSIPKRLIKKRNDKLMDYEASR-------TKEKGLGKRDFAEIQKDYEALNTQVKQQLP 837
BLAST of Rho guanine nucleotide exchange factor 38 vs. Ensembl Celegans
Match: Y37A1B.17 (pep chromosome:WBcel235:IV:13964359:13979696:-1 gene:WBGene00044989.1 transcript:Y37A1B.17c.2 gene_biotype:protein_coding transcript_biotype:protein_coding gene_symbol:Y37A1B.17) HSP 1 Score: 66.2402 bits (160), Expect = 1.683e-10 Identity = 83/326 (25.46%), Postives = 134/326 (41.10%), Query Frame = 3
Query: 1698 VGSVFLQSVSSFEEVYKEYCVNYDRKLDLINKKSKASNVTDFVSDGLNRLNDLGVFASTLDMMLVKPLQRFLKYPLFLKTIIENTLPDHPDINDLIAASSEFDVLAQKINEKKRFEELRQ--ITFDRTEKWHM---RTIHAIQKKPKRVIVSISGAVQN----EDTEYQEIVIKFKELKKCISFFIETVFILRDNL---KEILNLYSAITDDFTSIIKSNFGSQLHFYLVACKRGETDYFKKYYTVANKTCILDSLVVNPLNKLLELFSGPALLIKKRQSKYIDYLAMKQRCDDKETSRVQIDKLD--QLRNQYLAINNTLKHELP 2633
+G+ FLQ F + Y Y N + L N + + D + R+ + G + +P+QR KYPLFL I++ T H D L A + L QK+NE KR +EL Q ++ D+ M T H+++KK R + ++ DT++ +V + ++ + F + I R + +L + + S QL + A K + + AN I D +V L S P LIKKR K +DY A + T + K D +++ Y A+N +K +LP
Sbjct: 398 IGACFLQLRKPFAQTYGFYFRNIEHINALTNSAKHEKTMESALQDIVKRMRESGSVVIDGPTAVSRPIQRATKYPLFLNEIVKLTPLVHTDHPKLTEAIKQMSNLGQKMNESKRRKELTQKYMSDDKQTFGEMLSKMTFHSLKKKSNRFTYRMGSSLGVVKLLRDTDFDRLVCELDSAERRLVRFNYMMVIYRKKMFHETRVLMHKKVVEPRKKHLSSSEIDLQLQPFNHA--------IKTWASEAN-VRIRDEIV-------KALRSIPKRLIKKRNDKLMDYEASR-------TKEKGLGKRDFAEIQKDYEALNTQVKQQLP 700
BLAST of Rho guanine nucleotide exchange factor 38 vs. Ensembl Celegans
Match: Y37A1B.17 (pep chromosome:WBcel235:IV:13964367:13978981:-1 gene:WBGene00044989.1 transcript:Y37A1B.17c.1 gene_biotype:protein_coding transcript_biotype:protein_coding gene_symbol:Y37A1B.17) HSP 1 Score: 66.2402 bits (160), Expect = 1.683e-10 Identity = 83/326 (25.46%), Postives = 134/326 (41.10%), Query Frame = 3
Query: 1698 VGSVFLQSVSSFEEVYKEYCVNYDRKLDLINKKSKASNVTDFVSDGLNRLNDLGVFASTLDMMLVKPLQRFLKYPLFLKTIIENTLPDHPDINDLIAASSEFDVLAQKINEKKRFEELRQ--ITFDRTEKWHM---RTIHAIQKKPKRVIVSISGAVQN----EDTEYQEIVIKFKELKKCISFFIETVFILRDNL---KEILNLYSAITDDFTSIIKSNFGSQLHFYLVACKRGETDYFKKYYTVANKTCILDSLVVNPLNKLLELFSGPALLIKKRQSKYIDYLAMKQRCDDKETSRVQIDKLD--QLRNQYLAINNTLKHELP 2633
+G+ FLQ F + Y Y N + L N + + D + R+ + G + +P+QR KYPLFL I++ T H D L A + L QK+NE KR +EL Q ++ D+ M T H+++KK R + ++ DT++ +V + ++ + F + I R + +L + + S QL + A K + + AN I D +V L S P LIKKR K +DY A + T + K D +++ Y A+N +K +LP
Sbjct: 398 IGACFLQLRKPFAQTYGFYFRNIEHINALTNSAKHEKTMESALQDIVKRMRESGSVVIDGPTAVSRPIQRATKYPLFLNEIVKLTPLVHTDHPKLTEAIKQMSNLGQKMNESKRRKELTQKYMSDDKQTFGEMLSKMTFHSLKKKSNRFTYRMGSSLGVVKLLRDTDFDRLVCELDSAERRLVRFNYMMVIYRKKMFHETRVLMHKKVVEPRKKHLSSSEIDLQLQPFNHA--------IKTWASEAN-VRIRDEIV-------KALRSIPKRLIKKRNDKLMDYEASR-------TKEKGLGKRDFAEIQKDYEALNTQVKQQLP 700
BLAST of Rho guanine nucleotide exchange factor 38 vs. Ensembl Celegans
Match: uig-1 (UNC-112-Interacting Guanine nucleotide exchange factor [Source:UniProtKB/TrEMBL;Acc:H1UBJ0]) HSP 1 Score: 60.8474 bits (146), Expect = 5.452e-9 Identity = 54/192 (28.12%), Postives = 92/192 (47.92%), Query Frame = 3
Query: 1527 QDLKITLEAFDKNLIPTKIPDQDFHLLFGDLKSVIAVAEEFLSKLSANMEDGLDKIAVGSVFLQSVSSFEEVYKEYCVNYDRKLDLINKKSKASNVTDFVSDGLNRLNDLGVFASTLDMMLVKPLQRFLKYPLFLKTIIENTLPDHPDINDLIAASSEFDVL---AQKIN-EKKRFEELRQITFDRT--EKW 2084
+ LK+TL+A LFG ++ + A ++ ++L A LD + + F++S FE+ Y EYC NY R + + + V + + LN + L L+KP+QR LKY LFL+ I++N +P +LI +V+ A +IN EKK+ E + ++ ++ +KW
Sbjct: 258 EKLKVTLDAISS--------------LFGCIERIFAFNKQLYNQLDA---ADLDCVKMSRCFVESSGKFED-YIEYCTNYHRMMSTLYHLQQQPLVARALQERQLALN----HSLQLSAYLLKPVQRILKYHLFLENILKN-MPSTTHPEELIQVKRAHEVMTSQAARINDEKKKAEHIERVGQLQSTLQKW 426
BLAST of Rho guanine nucleotide exchange factor 38 vs. Ensembl Celegans
Match: uig-1 (UNC-112-Interacting Guanine nucleotide exchange factor [Source:UniProtKB/TrEMBL;Acc:H1UBJ0]) HSP 1 Score: 60.8474 bits (146), Expect = 5.615e-9 Identity = 54/192 (28.12%), Postives = 92/192 (47.92%), Query Frame = 3
Query: 1527 QDLKITLEAFDKNLIPTKIPDQDFHLLFGDLKSVIAVAEEFLSKLSANMEDGLDKIAVGSVFLQSVSSFEEVYKEYCVNYDRKLDLINKKSKASNVTDFVSDGLNRLNDLGVFASTLDMMLVKPLQRFLKYPLFLKTIIENTLPDHPDINDLIAASSEFDVL---AQKIN-EKKRFEELRQITFDRT--EKW 2084
+ LK+TL+A LFG ++ + A ++ ++L A LD + + F++S FE+ Y EYC NY R + + + V + + LN + L L+KP+QR LKY LFL+ I++N +P +LI +V+ A +IN EKK+ E + ++ ++ +KW
Sbjct: 291 EKLKVTLDAISS--------------LFGCIERIFAFNKQLYNQLDA---ADLDCVKMSRCFVESSGKFED-YIEYCTNYHRMMSTLYHLQQQPLVARALQERQLALN----HSLQLSAYLLKPVQRILKYHLFLENILKN-MPSTTHPEELIQVKRAHEVMTSQAARINDEKKKAEHIERVGQLQSTLQKW 459
BLAST of Rho guanine nucleotide exchange factor 38 vs. Ensembl Fly
Match: sif (gene:FBgn0085447 transcript:FBtr0330126) HSP 1 Score: 63.929 bits (154), Expect = 1.222e-9 Identity = 48/187 (25.67%), Postives = 87/187 (46.52%), Query Frame = 3
Query: 1575 TKIPDQDFHLLFGDLKSVIAVAEEFLSKL--SANMEDGLDKI-----------AVGSVFLQSVSSFEEVYKEYCVNYDRKLDLINKKSKASNVTDFVSDGLNRLNDLGVFASTLDMMLVKPLQRFLKYPLFLKTIIENTLPDHPDINDLIAASSEFDVLAQKINEKKRFEELRQITFDRTEKWHMRT 2096
T + + + + LFG++ ++ +FL L S ++E +K A+GS FL V+ F+ +Y +C ++ + +++ + +F L N +STL+ L+KP+QR LKYPL L+ + T + L A + +A+ INE +R E FD + H ++
Sbjct: 1459 TFLSNAEINALFGNIHEIVTFQRQFLQNLEESLDLEPDFNKFEHCGQFRNVLFAIGSAFLYYVNHFK-LYSSFCASHSKAQKVLHPNEGNHALQEF----LAARNPKQQHSSTLESYLIKPIQRILKYPLLLQQMRNLTDTRADEHVHLCEALKGMEKVAEHINEMQRIHEEYGAIFDHLFRQHQKS 1640
BLAST of Rho guanine nucleotide exchange factor 38 vs. Ensembl Fly
Match: sif (gene:FBgn0085447 transcript:FBtr0330123) HSP 1 Score: 63.929 bits (154), Expect = 1.227e-9 Identity = 48/187 (25.67%), Postives = 87/187 (46.52%), Query Frame = 3
Query: 1575 TKIPDQDFHLLFGDLKSVIAVAEEFLSKL--SANMEDGLDKI-----------AVGSVFLQSVSSFEEVYKEYCVNYDRKLDLINKKSKASNVTDFVSDGLNRLNDLGVFASTLDMMLVKPLQRFLKYPLFLKTIIENTLPDHPDINDLIAASSEFDVLAQKINEKKRFEELRQITFDRTEKWHMRT 2096
T + + + + LFG++ ++ +FL L S ++E +K A+GS FL V+ F+ +Y +C ++ + +++ + +F L N +STL+ L+KP+QR LKYPL L+ + T + L A + +A+ INE +R E FD + H ++
Sbjct: 1489 TFLSNAEINALFGNIHEIVTFQRQFLQNLEESLDLEPDFNKFEHCGQFRNVLFAIGSAFLYYVNHFK-LYSSFCASHSKAQKVLHPNEGNHALQEF----LAARNPKQQHSSTLESYLIKPIQRILKYPLLLQQMRNLTDTRADEHVHLCEALKGMEKVAEHINEMQRIHEEYGAIFDHLFRQHQKS 1670
BLAST of Rho guanine nucleotide exchange factor 38 vs. Ensembl Fly
Match: sif (gene:FBgn0085447 transcript:FBtr0112709) HSP 1 Score: 63.5438 bits (153), Expect = 1.401e-9 Identity = 48/187 (25.67%), Postives = 87/187 (46.52%), Query Frame = 3
Query: 1575 TKIPDQDFHLLFGDLKSVIAVAEEFLSKL--SANMEDGLDKI-----------AVGSVFLQSVSSFEEVYKEYCVNYDRKLDLINKKSKASNVTDFVSDGLNRLNDLGVFASTLDMMLVKPLQRFLKYPLFLKTIIENTLPDHPDINDLIAASSEFDVLAQKINEKKRFEELRQITFDRTEKWHMRT 2096
T + + + + LFG++ ++ +FL L S ++E +K A+GS FL V+ F+ +Y +C ++ + +++ + +F L N +STL+ L+KP+QR LKYPL L+ + T + L A + +A+ INE +R E FD + H ++
Sbjct: 1450 TFLSNAEINALFGNIHEIVTFQRQFLQNLEESLDLEPDFNKFEHCGQFRNVLFAIGSAFLYYVNHFK-LYSSFCASHSKAQKVLHPNEGNHALQEF----LAARNPKQQHSSTLESYLIKPIQRILKYPLLLQQMRNLTDTRADEHVHLCEALKGMEKVAEHINEMQRIHEEYGAIFDHLFRQHQKS 1631
BLAST of Rho guanine nucleotide exchange factor 38 vs. Ensembl Fly
Match: sif (gene:FBgn0085447 transcript:FBtr0112712) HSP 1 Score: 63.5438 bits (153), Expect = 1.411e-9 Identity = 48/187 (25.67%), Postives = 87/187 (46.52%), Query Frame = 3
Query: 1575 TKIPDQDFHLLFGDLKSVIAVAEEFLSKL--SANMEDGLDKI-----------AVGSVFLQSVSSFEEVYKEYCVNYDRKLDLINKKSKASNVTDFVSDGLNRLNDLGVFASTLDMMLVKPLQRFLKYPLFLKTIIENTLPDHPDINDLIAASSEFDVLAQKINEKKRFEELRQITFDRTEKWHMRT 2096
T + + + + LFG++ ++ +FL L S ++E +K A+GS FL V+ F+ +Y +C ++ + +++ + +F L N +STL+ L+KP+QR LKYPL L+ + T + L A + +A+ INE +R E FD + H ++
Sbjct: 1470 TFLSNAEINALFGNIHEIVTFQRQFLQNLEESLDLEPDFNKFEHCGQFRNVLFAIGSAFLYYVNHFK-LYSSFCASHSKAQKVLHPNEGNHALQEF----LAARNPKQQHSSTLESYLIKPIQRILKYPLLLQQMRNLTDTRADEHVHLCEALKGMEKVAEHINEMQRIHEEYGAIFDHLFRQHQKS 1651
BLAST of Rho guanine nucleotide exchange factor 38 vs. Ensembl Fly
Match: sif (gene:FBgn0085447 transcript:FBtr0112710) HSP 1 Score: 63.5438 bits (153), Expect = 1.414e-9 Identity = 48/187 (25.67%), Postives = 87/187 (46.52%), Query Frame = 3
Query: 1575 TKIPDQDFHLLFGDLKSVIAVAEEFLSKL--SANMEDGLDKI-----------AVGSVFLQSVSSFEEVYKEYCVNYDRKLDLINKKSKASNVTDFVSDGLNRLNDLGVFASTLDMMLVKPLQRFLKYPLFLKTIIENTLPDHPDINDLIAASSEFDVLAQKINEKKRFEELRQITFDRTEKWHMRT 2096
T + + + + LFG++ ++ +FL L S ++E +K A+GS FL V+ F+ +Y +C ++ + +++ + +F L N +STL+ L+KP+QR LKYPL L+ + T + L A + +A+ INE +R E FD + H ++
Sbjct: 1459 TFLSNAEINALFGNIHEIVTFQRQFLQNLEESLDLEPDFNKFEHCGQFRNVLFAIGSAFLYYVNHFK-LYSSFCASHSKAQKVLHPNEGNHALQEF----LAARNPKQQHSSTLESYLIKPIQRILKYPLLLQQMRNLTDTRADEHVHLCEALKGMEKVAEHINEMQRIHEEYGAIFDHLFRQHQKS 1640
BLAST of Rho guanine nucleotide exchange factor 38 vs. Ensembl Zebrafish
Match: dnmbp (dynamin binding protein [Source:NCBI gene;Acc:100005174]) HSP 1 Score: 151.369 bits (381), Expect = 2.293e-36 Identity = 145/572 (25.35%), Postives = 256/572 (44.76%), Query Frame = 3
Query: 1527 QDLKITLEAFDKNLIPTKIPDQDFHLLFGDLKSVIAVAEEFLSKLSANMEDGLDKIAVGSVFLQSVSSFEEVYKEYCVNYDRKLDLINKKSKASNVTDFVSDGLNRLNDLGVFASTLDMMLVKPLQRFLKYPLFLKTIIENTLPDHPDINDLIAASSEFDVLAQKINEKKRFEEL----RQITFDR-TEKWHMRTIHAIQKKPKRV---IVSISG-AVQNEDTEYQEIVIKFKELKKCISFFIETVFILRDNLKEILNLYSAITDDFTSIIKSNFGSQLHFYLVACKRGETDYFKKYYTVANKTCILD-----------SLVVNPLNKLLELFSGPALLIKKRQSKYIDYLAMKQRCDDKETSRVQIDKLDQLRNQYLAINNTLKHELPILISKSSVIFNECIGNYLQLSTSTLQSNILSLKNLI--------EGDQLSTEEEQRNCRNHQNEILAFLQRDLLSFNPQ-YRNSINKGDXXXXXXXXXXXXXXXXXXVYNQTETDVIKLREKFEPENLARVKKDFVPTKPHQIHICAGTLVGILKRCNPQGHSTSWLVEVCPKRTGFVPRSYL 3155
+DL++ ++ + L ++ DF LFG++ SVI ++ L D ++G VFL E+VYK YC N+D + L+ K N+ V + L +L + + L L+KP+QR ++YPL L ++ T H D L A + INE KR ++L R+ DR +K ++H+I KK RV + ++G + Q +D + + +F+ ++ I FI + + +++E ++ F I Y ++ + + F++ + CI D +LV+ PL +LL +F+GP LI+KR+ K +DY K+R + + RVQ ++L RN Y A+N L ELP + +F C+ ++Q + + L L+ EG+ +S +E+ +L LQ SF P+ ++ K QT+ L ++ PENL + +++F + + + G +VG++K+ +P G WL++ + GFV S+L
Sbjct: 769 KDLQMCVKEIIQPLQKKQVQGIDFDGLFGNISSVIDLSRRLNKTLQ-------DTDSIGQVFLSYKDQLEDVYKIYCQNHDDAISLLETYEKDENIQKHVLECLEKLRGKTNYIN-LGSFLIKPVQRVMRYPLLLMELLNTTPESHHDRQQLSEAVMSIKEINVNINEYKRRKDLVVKYRKGDEDRLIDKISKLSMHSIIKKSNRVSSHLKHLTGISPQIKDEAFDDAEKRFRLQERLIKSFIRNISLYLQHIRESASVKVLAAISFCDI-----------YTERQQQMDPERFQRAHR-----CISDKQFTEFKERTEALVITPLTQLLNMFTGPHKLIQKRRDKLLDYDNCKERAERLKDKRVQ-EELQTARNNYEALNAQLLDELPKFHRAAEDLFTSCVRGFVQAQRDFISLTLGELTPLLQLSGLGGTEGNLVSLFQEE------HTRVLDLLQS--FSFFPENLPTTVRKTFEKKTLEKQYTKKPQAPPNYVLQTDEHRAGLLVRYGPENLYQAERNFNAAQDLDVSVLEGDIVGVIKQQDPMGSQNRWLIDNGVTK-GFVYSSFL 1306
BLAST of Rho guanine nucleotide exchange factor 38 vs. Ensembl Zebrafish
Match: dnmbp (dynamin binding protein [Source:NCBI gene;Acc:100005174]) HSP 1 Score: 150.984 bits (380), Expect = 3.072e-36 Identity = 146/579 (25.22%), Postives = 257/579 (44.39%), Query Frame = 3
Query: 1527 QDLKITLEAFDKNLIPTKIPDQDFHLLFGDLKSVIAVAEEFLSKLSANMEDGLDKIAVGSVFLQSVSSFEEVYKEYCVNYDRKLDLINKKSKASNVTDFVSDGLNRLNDLGVFAS-------TLDMMLVKPLQRFLKYPLFLKTIIENTLPDHPDINDLIAASSEFDVLAQKINEKKRFEEL----RQITFDR-TEKWHMRTIHAIQKKPKRV---IVSISG-AVQNEDTEYQEIVIKFKELKKCISFFIETVFILRDNLKEILNLYSAITDDFTSIIKSNFGSQLHFYLVACKRGETDYFKKYYTVANKTCILD-----------SLVVNPLNKLLELFSGPALLIKKRQSKYIDYLAMKQRCDDKETSRVQIDKLDQLRNQYLAINNTLKHELPILISKSSVIFNECIGNYLQLSTSTLQSNILSLKNLI--------EGDQLSTEEEQRNCRNHQNEILAFLQRDLLSFNPQ-YRNSINKGDXXXXXXXXXXXXXXXXXXVYNQTETDVIKLREKFEPENLARVKKDFVPTKPHQIHICAGTLVGILKRCNPQGHSTSWLVEVCPKRTGFVPRSYL 3155
+DL++ ++ + L ++ DF LFG++ SVI ++ L D ++G VFL E+VYK YC N+D + L+ K N+ V + L +L G++ L L+KP+QR ++YPL L ++ T H D L A + INE KR ++L R+ DR +K ++H+I KK RV + ++G + Q +D + + +F+ ++ I FI + + +++E ++ F I Y ++ + + F++ + CI D +LV+ PL +LL +F+GP LI+KR+ K +DY K+R + + RVQ ++L RN Y A+N L ELP + +F C+ ++Q + + L L+ EG+ +S +E+ +L LQ SF P+ ++ K QT+ L ++ PENL + +++F + + + G +VG++K+ +P G WL++ + GFV S+L
Sbjct: 769 KDLQMCVKEIIQPLQKKQVQGIDFDGLFGNISSVIDLSRRLNKTLQ-------DTDSIGQVFLSYKDQLEDVYKIYCQNHDDAISLLETYEKDENIQKHVLECLEKLR--GIYREWGKTNYINLGSFLIKPVQRVMRYPLLLMELLNTTPESHHDRQQLSEAVMSIKEINVNINEYKRRKDLVVKYRKGDEDRLIDKISKLSMHSIIKKSNRVSSHLKHLTGISPQIKDEAFDDAEKRFRLQERLIKSFIRNISLYLQHIRESASVKVLAAISFCDI-----------YTERQQQMDPERFQRAHR-----CISDKQFTEFKERTEALVITPLTQLLNMFTGPHKLIQKRRDKLLDYDNCKERAERLKDKRVQ-EELQTARNNYEALNAQLLDELPKFHRAAEDLFTSCVRGFVQAQRDFISLTLGELTPLLQLSGLGGTEGNLVSLFQEE------HTRVLDLLQS--FSFFPENLPTTVRKTFEKKTLEKQYTKKPQAPPNYVLQTDEHRAGLLVRYGPENLYQAERNFNAAQDLDVSVLEGDIVGVIKQQDPMGSQNRWLIDNGVTK-GFVYSSFL 1312
BLAST of Rho guanine nucleotide exchange factor 38 vs. Ensembl Zebrafish
Match: dnmbp (dynamin binding protein [Source:NCBI gene;Acc:100005174]) HSP 1 Score: 150.599 bits (379), Expect = 4.206e-36 Identity = 145/568 (25.53%), Postives = 254/568 (44.72%), Query Frame = 3
Query: 1527 QDLKITLEAFDKNLIPTKIPDQDFHLLFGDLKSVIAVAEEFLSKLSANMEDGLDKIAVGSVFLQSVSSFEEVYKEYCVNYDRKLDLINKKSKASNVTDFVSDGLNRLNDLGVFAS-------TLDMMLVKPLQRFLKYPLFLKTIIENTLPDHPDINDLIAASSEFDVLAQKINEKKRFEEL----RQITFDR-TEKWHMRTIHAIQKKPKRV---IVSISG-AVQNEDTEYQEIVIKFKELKKCISFFIETVFILRDNLKEILNLYSAITDDFTSIIKSNFGSQLHFYLVACKRGETDYFKKYYTVANKTCILDSLVVNPLNKLLELFSGPALLIKKRQSKYIDYLAMKQRCDDKETSRVQIDKLDQLRNQYLAINNTLKHELPILISKSSVIFNECIGNYLQLSTSTLQSNILSLKNLI--------EGDQLSTEEEQRNCRNHQNEILAFLQRDLLSFNPQ-YRNSINKGDXXXXXXXXXXXXXXXXXXVYNQTETDVIKLREKFEPENLARVKKDFVPTKPHQIHICAGTLVGILKRCNPQGHSTSWLVEVCPKRTGFVPRSYL 3155
+DL++ ++ + L ++ DF LFG++ SVI ++ L D ++G VFL E+VYK YC N+D + L+ K N+ V + L +L G++ L L+KP+QR ++YPL L ++ T H D L A + INE KR ++L R+ DR +K ++H+I KK RV + ++G + Q +D + + +F+ ++ I FI + + +++E ++ F I R +D K++ +T ++LV+ PL +LL +F+GP LI+KR+ K +DY K+R + + RVQ ++L RN Y A+N L ELP + +F C+ ++Q + + L L+ EG+ +S +E+ +L LQ SF P+ ++ K QT+ L ++ PENL + +++F + + + G +VG++K+ +P G WL++ + GFV S+L
Sbjct: 867 KDLQMCVKEIIQPLQKKQVQGIDFDGLFGNISSVIDLSRRLNKTLQ-------DTDSIGQVFLSYKDQLEDVYKIYCQNHDDAISLLETYEKDENIQKHVLECLEKLR--GIYREWGKTNYINLGSFLIKPVQRVMRYPLLLMELLNTTPESHHDRQQLSEAVMSIKEINVNINEYKRRKDLVVKYRKGDEDRLIDKISKLSMHSIIKKSNRVSSHLKHLTGISPQIKDEAFDDAEKRFRLQERLIKSFIRNISLYLQHIRESASVKVLAAISFCDIYTERQQQMDPERFQRAHRCISD--KQFTEFKERT---EALVITPLTQLLNMFTGPHKLIQKRRDKLLDYDNCKERAERLKDKRVQ-EELQTARNNYEALNAQLLDELPKFHRAAEDLFTSCVRGFVQAQRDFISLTLGELTPLLQLSGLGGTEGNLVSLFQEE------HTRVLDLLQS--FSFFPENLPTTVRKTFEKKTLEKQYTKKPQAPPNYVLQTDEHRAGLLVRYGPENLYQAERNFNAAQDLDVSVLEGDIVGVIKQQDPMGSQNRWLIDNGVTK-GFVYSSFL 1410
BLAST of Rho guanine nucleotide exchange factor 38 vs. Ensembl Zebrafish
Match: arhgef38 (Rho guanine nucleotide exchange factor (GEF) 38 [Source:ZFIN;Acc:ZDB-GENE-090313-83]) HSP 1 Score: 135.576 bits (340), Expect = 6.842e-32 Identity = 180/730 (24.66%), Postives = 323/730 (44.25%), Query Frame = 3
Query: 1455 ILEKKMQKRSXXXXXXXXXXXXXXQDLKITLEAFDKNLIPTKIPDQDFHLLFGDLKSVIAVAEEFLSKLSANMED-GLDKIAVGSVFLQSVSSFEEVYKEYCVNYDRKLDLINKKSKASNVTDFVSD-------GLNRLNDLGVFASTLDM--MLVKPLQRFLKYPLFLKTIIENTLPDHPDINDLIAASSEFDVLAQKINEKKRFEELRQITFDRTE-------KWHMRTIHAIQKKPKR------VIVSISGAVQNEDTEYQEIVIKFKELKKCISFFIETVFILRDNLKEILNLYSAITDDFTSIIKSNFGSQLHFYLVACKRGETDYFKKYYTVANKTCILDSLVVNPLNKLLELFSGPALLIKKRQSKYIDYLA-MKQRCDDKETSRVQIDKLDQLRNQYLAINNTLKHELPILISKSSVIFNECIGNYLQLSTSTLQSNILSLKNLIEGDQLSTEE---EQRNCRNHQNEILAFLQRDLLSFNPQYRNSINKGDXXXXXXXXXXXXXXXXXXVYNQTETDVIKLREKFEPENLARVKKDFVPTKPHQIHICAGTLVGILKRCNPQGHSTSWLVEVCPKRTGFVPRSYLTLSPFAANKVDLIGSKVISGNATYLNNRHSITADSSFD-LMQFSPNNHDDTLRQISMVE-ISPVKTRPRAFSTANIIRI-ALFPHQSRGESEISMQKNDQLEILESPDKSNSRNWSLAKNLRTGAQGYVPTNYLSK 3554
I +KM KRSK+IEE++ TE + +DL++ + L ++ D D LF +++SV V+ + L +L + D + +G VF+Q+ + EEVYK YC ++D N K+ + + L ++ DL + LDM +L+KP+QR +KYPL L + T DHPD L A + ++ INE KR +++ + + R++ K + IH+I+KK R ++ + V++E + +E + F+ L+K + ++ + +E++++ D SI+K ++ K+ D +K + ++ LVV PL+ LL +F+ P LI+KR K +DY + + R ++E + D Y A+N L EL + I C+ ++L ++ L++ Q ++ N QN I+ L L F + N ++ + + QTE +L E++ + L ++K++ + I + G LV +L+ +P G S+ WLV + G+V S+L Y R FD L F + ++R S + +SP T++ A++ ++R E E+++Q+ + IL+ D +++W LA++ G +GYVP NYL K
Sbjct: 105 IRHRKMIKRSKVIEELVRTEGDYQRDLELCINEVLLPLREAQVVDVD--RLFTNIESVCDVSNDLLLRLQDAIADPDPETQLIGEVFIQTKAVIEEVYKIYCYHHDE----ANASLKSYEAQEDIQQQFRRCISALKKIYDLEGKPNLLDMGSLLIKPVQRIMKYPLLLAELWNATPTDHPDHRPLQEALTTVKIINININEFKRRKDI-VLKYKRSDDETSLMGKLNKFNIHSIRKKSDRLTSYFKILTGVEPQVRDEAFDKEEKL--FRNLEKAVRQLVKNISCYLLYTQEMISVAVQNAQDLESIMKD--PDKIDTNGFHQKKNGNDPYKHFKDH------MEHLVVAPLSSLLGMFASPQKLIQKRYDKLLDYCSQLDSRSSNEEQGLAKRD--------YEALNAQLLEELQCFNQAARTILTNCLICIVKL-----------IRKLMDAAQPPVQQLPVPLSNFNEVQNSIMEELSN--LGFFKE-----NSQKLMERKVSFEKREKKMAPEILRQTEEQRARLLEEYPVKQLYQLKRNCNACQEKDISLLEGELVALLEDRDPMGSSSRWLVHTGSVQ-GYVYSSFLK---------------------AYNPQREVTERPDDFDNLSLFVSASRSSSMRSFSTSDSVSPQSAPQDELDTSDDQHFYAVYAFKARCEQELTLQEYQHVRILQFSDLGGNKDWWLAES--NGQKGYVPANYLGK 767
BLAST of Rho guanine nucleotide exchange factor 38 vs. Ensembl Zebrafish
Match: arhgef37 (Rho guanine nucleotide exchange factor (GEF) 37 [Source:ZFIN;Acc:ZDB-GENE-100514-3]) HSP 1 Score: 95.5153 bits (236), Expect = 1.906e-19 Identity = 151/592 (25.51%), Postives = 236/592 (39.86%), Query Frame = 3
Query: 1527 QDLKITLEAFDKNLIPTKIPDQDFHLLFGDLKSVIAVAEEFLSKL-SANMEDGLDKI--AVGSVFLQSVSSFEEVYKEYCVNYDRKLDLINK-KSKASNVTDFVSDGLNRLNDLGVFASTLDMMLVKPLQRFLKYPLFLKTIIENTLPDHPDINDLIAASSEFDVLAQKINEKKRFEELRQITFDRTE------KWHMRTIHAIQKKPKRVIVSISGAVQNEDTEYQEIVIKFK--ELKKCISFFIETVFILRDNLKEILNLYSAITDDFTSIIKSNFGSQLHFY--LVACKRGETD---------YFKKYYTVANKTCI-------LDSLVVNPLNKLLELFSGPALLIKKRQSKYIDYLAMKQRCDDKETSRVQIDKLDQLRNQYLAINNTLKHELPILISKS-----------SVIFNECIGNYLQLSTS---TLQSNILSLKNLIEGDQLSTEEEQRN----CRNHQNEILAFLQRDLLSFNPQYRNSINKGDXXXXXXXXXXXXXXXXXXVYNQTETDVIKLREKFEPENLARVKKDFVPTKPHQIHICAGTLVGILKRCNPQGHSTSWLVEVCPKRTGFVPRSYLT 3158
+ L+I + NL + P + +F + V+ V+ LS L A M+ K + FL E YKEY NY+ L N K K + + V + D V ASTL LV P+QR +YPL +TI ++T P HP +L + + +INE KRF E+ + +TE K + + H+I KK R S +++E IV K K E FF F+L + E + N + LH ++C+ E D F K TVA + I L +LV PL+ L EL +GP LI+KRQ K +DY + +E S + ++ + N Y +N L +ELP K+ SV+ + + QL+TS L + L + + + S E CR+ Q+E+ A + + L N+++K ++ L E + ++ V T+ + + G LV ++ + +G WLV+ R G+VP S L
Sbjct: 75 KHLQICTVTINSNLQKLQPPPPNLENMFQHIDEVMEVSSRLLSLLDQAQMQHSDPKYLETLCDSFLSLSQDIEMAYKEYLANYNNITALENSYKQKEALWMEMVRIIKSSAPD--VNASTLSFFLVMPVQRIARYPLLFQTIQKHTDPQHPAYPELEHTAHTAIQINCRINEYKRFREVAD-KYKKTENLTIKDKLNRLSGHSIAKKTAR----FSQYIKHETG----IVPKLKDEEFDALAGFF----FVLERGVSE---------------LHDNLLTYLHHLQRFLSCRPEEADLDLEGEKTALFSKEITVALRQWIYPSYEKRLKTLVFKPLSSLRELMAGPRNLIRKRQDKLLDYEPI------EEKSNLTFEE-QAIANTYKTMNTLLLNELPQFNGKALQLMWAALEAFSVLQRDLATDMEQLATSFTHQLPHSYLEAGDFWKWAETSVLEGSWRMESLCRSVQDELNAPIVQAL--------NTVSK--------------------------KRLMYLNANHGSEKIYQLTGPVVGTRDLDLTLNKGELVAVVCEMDTRGDRRRWLVDAGGPR-GYVPASKLA 594
BLAST of Rho guanine nucleotide exchange factor 38 vs. Ensembl Xenopus
Match: tlx3 (T cell leukemia homeobox 3 [Source:Xenbase;Acc:XB-GENE-495044]) HSP 1 Score: 163.31 bits (412), Expect = 5.234e-40 Identity = 196/808 (24.26%), Postives = 363/808 (44.93%), Query Frame = 3
Query: 1434 ESIKLGSILE----KKMQKRSXXXXXXXXXXXXXXQDLKITLEAFDKNLIPTKIPDQDFHLLFGDLKSVIAVAEEFLSKLSANMEDGLDKIAVGSVFLQSVSSFEEVYKEYCVNYDRKLDLINKKSK----ASNVTDFVSDGLNRLNDLGVFAS-TLDMMLVKPLQRFLKYPLFLKTIIENTLPDHPDINDLIAASSEFDVLAQKINEKKRFEEL--------RQITFDRTEKWHMRTIHAIQKKPKRV---IVSISG-AVQNEDTEYQEIVIKFKELKKCISFFIETVFILRDNLKE--------ILNLYSAITDDFTSIIKSNFGSQLHFYLVACKRGETDYFKKYYTVANKTCILDSLVVNPLNKLLELFSGPALLIKKRQSKYIDYLAMKQRCDDKETSRVQIDKLDQLRNQYLAINNTLKHELPILISKSSVIFNECIGNYLQLSTSTLQSNILSLKNLI--------EGDQLSTEEEQRNCRNHQNEILAFLQRDL-LSFNPQYRNSINKGDXXXXXXXXXXXXXXXXXXVYNQTETDVIKLREKFEPENLARVKKDFVPTKPHQIHICAGTLVGILKRCNPQGHSTSWLVEVCPKRTGFVPRSYLT-LSPFAANKVDLIGSKVISGNATYLNNRHSITADSSFDLMQFSPNNHD-------------DTLRQISMVEISP-------------------------VKTRPRAFSTANIIR------------------------IALFPHQSRGESEISMQKNDQLEILESPDKSNSRNWSLAKNLRTGAQGYVPTNYLSK 3554
+++ GS E + ++KRSK+IEE+L+TE+ +++DL+ +E + P ++ DF +LFG+++SVI ++++FL+ L ++ +VG+VFL S E VYKEYC N++ + L+ K N+ + + N + G L L+KP+QR ++YPL L ++ T HPD L A + INE KR ++L D+ K + IH+I KK RV I ++G A Q +D ++E F+ ++ I FI + + +++E ++++ +D TS ++ + H Y+ ++ TD+ ++ + LV++PLN+LL +F+GP L++KR K +D+ +R + + + Q ++L RN Y A+N L ELP + + +F C+ Y ++ + LK L+ EG+ ++ +E+ + Q ++ F +L S P R +I + + R + + + + + ++ PE L + + + + + + G LVG++K+ +P G WL++ + GFV S+L +P ++ +GS+ S + Y + + + +S + + F+P N D+ S E SP V + + F + IR A++ +SR +E+S+ N ++ ILE D + + W LA+ G +GYVP+NY+ K
Sbjct: 404 QTLSTGSTTENSEQRMLEKRSKVIEELLQTEQDYLRDLETCVEHI---MGPLQMASVDFDVLFGNIQSVIDISKKFLTALGSS-------DSVGTVFLDHASDLENVYKEYCQNHEETIALLEAYDKDEKFQKNLLECMETVKNLYQEWGRTNYINLGSFLIKPVQRIMRYPLLLMELLGATPDSHPDKAPLREAVQSVKDINGNINEYKRRKDLVLKYRKGDENSLIDKISKLN---IHSIIKKSNRVSSHIKQLTGFAPQIKDEAFEETEKNFRMQERLIKSFIRDLSVYLQHVRESACVKVLAAMSMWDLYSDKGTSDLEK--FHKAHRYI--SEKLFTDFKQR----------TEKLVISPLNQLLNMFAGPHKLVQKRFDKLLDFHNCTERAEKLKDKKTQ-EELQSARNNYEALNAQLLDELPKFHNFAKELFASCMRGYASAHCEFVKLALEELKPLLTLLGVGATEGNLIAVFQEEHSKVLQQLQVFTFFPENLPPSKKPFERKTIER--------------QSARKTIPSPLDEHRVAVLARYPPEKLFQADRIYNAAQDLDVSLQEGDLVGVIKQQDPMGSQNRWLIDNGVTK-GFVYCSFLKPYNPRQSHSDASVGSQS-STESGYGGSSPNFSRQNSNNTLTFNPGNSTVAFTAGSIAKHSMDSTSTSSGQEDSPVCLPDGNLSKKSSETEVRQTENENSVGDKEQTFESRKAIRKKTASPAHSDCEQDVCELEGNQVYYAVYTFKSRSPNELSVSANQRVNILEFRDMNGNGEWWLAE--VEGRRGYVPSNYIRK 1165
BLAST of Rho guanine nucleotide exchange factor 38 vs. Ensembl Xenopus
Match: tlx3 (T cell leukemia homeobox 3 [Source:Xenbase;Acc:XB-GENE-495044]) HSP 1 Score: 157.147 bits (396), Expect = 5.902e-38 Identity = 169/664 (25.45%), Postives = 314/664 (47.29%), Query Frame = 3
Query: 1422 ENDYESIKLGSILE----KKMQKRSXXXXXXXXXXXXXXQDLKITLEAFDKNLIPTKIPDQDFHLLFGDLKSVIAVAEEFLSKLSANMEDGLDKIAVGSVFLQSVSSFEEVYKEYCVNYDRKLDLINKKSK----ASNVTDFVSDGLNRLN--DLGVFASTLDMMLVKPLQRFLKYPLFLKTIIENTLPDHPDINDLIAASSEFDVLAQKINEKKRFEEL--------RQITFDRTEKWHMRTIHAIQKKPKRV---IVSISG-AVQNEDTEYQEIVIKFKELKKCISFFIETVFILRDNLKE--------ILNLYSAITDDFTSIIKSNFGSQLHFYLVACKRGETDYFKKYYTVANKTCILDSLVVNPLNKLLELFSGPALLIKKRQSKYIDYLAMKQRCDDKETSRVQIDKLDQLRNQYLAINNTLKHELPILISKSSVIFNECIGNYLQLSTSTLQSNILSLKNLI--------EGDQLSTEEEQRNCRNHQNEILAFLQRDL-LSFNPQYRNSINKGDXXXXXXXXXXXXXXXXXXVYNQTETDVIKLREKFEPENLARVKKDFVPTKPHQIHICAGTLVGILKRCNPQGHSTSWLVEVCPKRTGFVPRSYL-TLSPFAANKVDLIGSKVISGNATYLNNRHSITADSSFDLMQFSPNN 3293
E +++ GS E + ++KRSK+IEE+L+TE+ +++DL+ +E L ++ DF +LFG+++SVI ++++FL+ L ++ +VG+VFL S E VYKEYC N++ + L+ K N+ + + R N +LG F L+KP+QR ++YPL L ++ T HPD L A + INE KR ++L D+ K + IH+I KK RV I ++G A Q +D ++E F+ ++ I FI + + +++E ++++ +D TS ++ + H Y+ ++ TD+ ++ + LV++PLN+LL +F+GP L++KR K +D+ +R + + + Q ++L RN Y A+N L ELP + + +F C+ Y ++ + LK L+ EG+ ++ +E+ + Q ++ F +L S P R +I + Q + + + ++ PE L + + + + + + G LVG++K+ +P G WL++ + GFV S+L +P ++ +GS+ S + Y + + + +S + + F+P N
Sbjct: 629 EGAEQTLSTGSTTENSEQRMLEKRSKVIEELLQTEQDYLRDLETCVEHIMGPLQAKQMASVDFDVLFGNIQSVIDISKKFLTALGSS-------DSVGTVFLDHASDLENVYKEYCQNHEETIALLEAYDKDEKFQKNLLECMETVKGRTNYINLGSF-------LIKPVQRIMRYPLLLMELLGATPDSHPDKAPLREAVQSVKDINGNINEYKRRKDLVLKYRKGDENSLIDKISKLN---IHSIIKKSNRVSSHIKQLTGFAPQIKDEAFEETEKNFRMQERLIKSFIRDLSVYLQHVRESACVKVLAAMSMWDLYSDKGTSDLEKFH--KAHRYI--SEKLFTDFKQR----------TEKLVISPLNQLLNMFAGPHKLVQKRFDKLLDFHNCTERAEKLKDKKTQ-EELQSARNNYEALNAQLLDELPKFHNFAKELFASCMRGYASAHCEFVKLALEELKPLLTLLGVGATEGNLIAVFQEEHSKVLQQLQVFTFFPENLPPSKKPFERKTIER--------QSARKTIPSPAKYIPQLDEHRVAVLARYPPEKLFQADRIYNAAQDLDVSLQEGDLVGVIKQQDPMGSQNRWLIDNGVTK-GFVYCSFLKPYNPRQSHSDASVGSQS-STESGYGGSSPNFSRQNSNNTLTFNPGN 1250
BLAST of Rho guanine nucleotide exchange factor 38 vs. Ensembl Xenopus
Match: tlx3 (T cell leukemia homeobox 3 [Source:Xenbase;Acc:XB-GENE-495044]) HSP 1 Score: 154.836 bits (390), Expect = 3.141e-37 Identity = 167/663 (25.19%), Postives = 312/663 (47.06%), Query Frame = 3
Query: 1422 ENDYESIKLGSILE----KKMQKRSXXXXXXXXXXXXXXQDLKITLEAFDKNLIPTKIPDQDFHLLFGDLKSVIAVAEEFLSKLSANMEDGLDKIAVGSVFLQSVSSFEEVYKEYCVNYDRKLDLINKKSK----ASNVTDFVSDGLNRLNDLG-VFASTLDMMLVKPLQRFLKYPLFLKTIIENTLPDHPDINDLIAASSEFDVLAQKINEKKRFEEL--------RQITFDRTEKWHMRTIHAIQKKPKRV---IVSISG-AVQNEDTEYQEIVIKFKELKKCISFFIETVFILRDNLKE--------ILNLYSAITDDFTSIIKSNFGSQLHFYLVACKRGETDYFKKYYTVANKTCILDSLVVNPLNKLLELFSGPALLIKKRQSKYIDYLAMKQRCDDKETSRVQIDKLDQLRNQYLAINNTLKHELPILISKSSVIFNECIGNYLQLSTSTLQSNILSLKNLI--------EGDQLSTEEEQRNCRNHQNEILAFLQRDL-LSFNPQYRNSINKGDXXXXXXXXXXXXXXXXXXVYNQTETDVIKLREKFEPENLARVKKDFVPTKPHQIHICAGTLVGILKRCNPQGHSTSWLVEVCPKRTGFVPRSYL-TLSPFAANKVDLIGSKVISGNATYLNNRHSITADSSFDLMQFSPNN 3293
E +++ GS E + ++KRSK+IEE+L+TE+ +++DL+ +E L ++ DF +LFG+++SVI ++++FL+ L ++ +VG+VFL S E VYKEYC N++ + L+ K N+ + + N + G L L+KP+QR ++YPL L ++ T HPD L A + INE KR ++L D+ K + IH+I KK RV I ++G A Q +D ++E F+ ++ I FI + + +++E ++++ +D TS ++ + H Y+ ++ TD+ ++ + LV++PLN+LL +F+GP L++KR K +D+ +R + + + Q ++L RN Y A+N L ELP + + +F C+ Y ++ + LK L+ EG+ ++ +E+ + Q ++ F +L S P R +I + Q + + + ++ PE L + + + + + + G LVG++K+ +P G WL++ + GFV S+L +P ++ +GS+ S + Y + + + +S + + F+P N
Sbjct: 707 EGAEQTLSTGSTTENSEQRMLEKRSKVIEELLQTEQDYLRDLETCVEHIMGPLQAKQMASVDFDVLFGNIQSVIDISKKFLTALGSS-------DSVGTVFLDHASDLENVYKEYCQNHEETIALLEAYDKDEKFQKNLLECMETVKNLYQEWGRTNYINLGSFLIKPVQRIMRYPLLLMELLGATPDSHPDKAPLREAVQSVKDINGNINEYKRRKDLVLKYRKGDENSLIDKISKLN---IHSIIKKSNRVSSHIKQLTGFAPQIKDEAFEETEKNFRMQERLIKSFIRDLSVYLQHVRESACVKVLAAMSMWDLYSDKGTSDLEKFH--KAHRYI--SEKLFTDFKQR----------TEKLVISPLNQLLNMFAGPHKLVQKRFDKLLDFHNCTERAEKLKDKKTQ-EELQSARNNYEALNAQLLDELPKFHNFAKELFASCMRGYASAHCEFVKLALEELKPLLTLLGVGATEGNLIAVFQEEHSKVLQQLQVFTFFPENLPPSKKPFERKTIER--------QSARKTIPSPAKYIPQLDEHRVAVLARYPPEKLFQADRIYNAAQDLDVSLQEGDLVGVIKQQDPMGSQNRWLIDNGVTK-GFVYCSFLKPYNPRQSHSDASVGSQS-STESGYGGSSPNFSRQNSNNTLTFNPGN 1334
BLAST of Rho guanine nucleotide exchange factor 38 vs. Ensembl Xenopus
Match: tlx3 (T cell leukemia homeobox 3 [Source:Xenbase;Acc:XB-GENE-495044]) HSP 1 Score: 154.451 bits (389), Expect = 3.572e-37 Identity = 172/679 (25.33%), Postives = 322/679 (47.42%), Query Frame = 3
Query: 1422 ENDYESIKLGSILE----KKMQKRSXXXXXXXXXXXXXXQDLKITLEAFDKNLIPTKIPDQDFHLLFGDLKSVIAVAEEFLSKLSANMEDGLDKIAVGSVFLQSVSSFEEVYKEYCVNYDRKLDLINKKSK----ASNVTDFVSDGLNRLNDLG-VFASTLDMMLVKPLQRFLKYPLFLKTIIENTLPDHPDINDLIAASSEFDVLAQKINEKKRFEEL--------RQITFDRTEKWHMRTIHAIQKKPKRV---IVSISG-AVQNEDTEYQEIVIKFKELKKCISFFIETVFILRDNLKE--------ILNLYSAITDDFTSIIKSNFGSQLHFYLVACKRGETDYFKKYYTVANKTCILDSLVVNPLNKLLELFSGPALLIKKRQSKYIDYLAMKQRCDDKETSRVQIDKLDQLRNQYLAINNTLKHELPILISKSSVIFNECIGNYLQLSTSTLQSNILSLKNLI--------EGDQLSTEEEQRNCRNHQNEILAFLQRDL-LSFNPQYRNSINKGDXXXXXXXXXXXXXXXXXXVYNQTETDVIKLREKFEPENLARVKKDFVPTKPHQIHICAGTLVGILKRCNPQGHSTSWLVEVCPKRTGFVPRSYL-TLSPFAANKVDLIGSKVISGNATYLNNRHSITADSSFDLMQFSPNNHDDTLRQISMVEISPV 3341
E +++ GS E + ++KRSK+IEE+L+TE+ +++DL+ +E + P ++ DF +LFG+++SVI ++++FL+ L ++ +VG+VFL S E VYKEYC N++ + L+ K N+ + + N + G L L+KP+QR ++YPL L ++ T HPD L A + INE KR ++L D+ K + IH+I KK RV I ++G A Q +D ++E F+ ++ I FI + + +++E ++++ +D TS ++ + H Y+ ++ TD+ ++ + LV++PLN+LL +F+GP L++KR K +D+ +R + + + Q ++L RN Y A+N L ELP + + +F C+ Y ++ + LK L+ EG+ ++ +E+ + Q ++ F +L S P R +I + + R + + + + + ++ PE L + + + + + + G LVG++K+ +P G WL++ + GFV S+L +P ++ +GS+ S + Y + + + +S + + F+P N S +E SPV
Sbjct: 744 EGAEQTLSTGSTTENSEQRMLEKRSKVIEELLQTEQDYLRDLETCVEHI---MGPLQMASVDFDVLFGNIQSVIDISKKFLTALGSS-------DSVGTVFLDHASDLENVYKEYCQNHEETIALLEAYDKDEKFQKNLLECMETVKNLYQEWGRTNYINLGSFLIKPVQRIMRYPLLLMELLGATPDSHPDKAPLREAVQSVKDINGNINEYKRRKDLVLKYRKGDENSLIDKISKLN---IHSIIKKSNRVSSHIKQLTGFAPQIKDEAFEETEKNFRMQERLIKSFIRDLSVYLQHVRESACVKVLAAMSMWDLYSDKGTSDLEKFH--KAHRYI--SEKLFTDFKQR----------TEKLVISPLNQLLNMFAGPHKLVQKRFDKLLDFHNCTERAEKLKDKKTQ-EELQSARNNYEALNAQLLDELPKFHNFAKELFASCMRGYASAHCEFVKLALEELKPLLTLLGVGATEGNLIAVFQEEHSKVLQQLQVFTFFPENLPPSKKPFERKTIER--------------QSARKTIPSPLDEHRVAVLARYPPEKLFQADRIYNAAQDLDVSLQEGDLVGVIKQQDPMGSQNRWLIDNGVTK-GFVYCSFLKPYNPRQSHSDASVGSQS-STESGYGGSSPNFSRQNSNNTLTFNPGNSTVAFTAGS-IEDSPV 1377
BLAST of Rho guanine nucleotide exchange factor 38 vs. Ensembl Xenopus
Match: tlx3 (T cell leukemia homeobox 3 [Source:Xenbase;Acc:XB-GENE-495044]) HSP 1 Score: 140.969 bits (354), Expect = 5.103e-33 Identity = 157/651 (24.12%), Postives = 286/651 (43.93%), Query Frame = 3
Query: 1422 ENDYESIKLGSILEKKMQKRSXXXXXXXXXXXXXXQDLKITLEAFDKNLIPTKIPDQDFHLLFGDLKSVIAVAEEFLSKLSANMEDGLDKIAVGSVFLQSVSSFEEVYKEYCVNYDRKLDLINKKSK----ASNVTDFVSDGLNRLNDLG-VFASTLDMMLVKPLQRFLKYPLFLKTIIENTLPDHPDINDLIAASSEFDVLAQKINEKKRFEEL--------RQITFDRTEKWHMRTIHAIQKKPKRV---IVSISG-AVQNEDTEYQEIVIKFKELKKCISFFIETVFILRDNLKEILNLYSAITDDFTSIIKSNFGSQLHFYLVACKRGETDYFKKYYTVANKTCILDSLVVNPLNKLLELFSGPALLIKKRQSKYIDYLAMKQRCDDKETSRVQIDKLDQLRNQYLAINNTLKHELPILISKSSVIFNECIGNYLQLSTSTLQSNILSLKNLI--------EGDQLSTEEEQRNCRNHQNEILAFLQRDL-LSFNPQYRNSINKGDXXXXXXXXXXXXXXXXXXVYNQTETDVIKLREKFEPENLARVKKDFVPTKPHQIHICAGTLVGILKRCNPQGHSTSWLVEVCPKRTGFVPRSYL-TLSPFAANKVDLIGSKVISGNATYLNNRHSITADSSFDLMQFSPNN 3293
E +++ GS E Q+ + +++E + QD LE ++++ + DF +LFG+++SVI ++++FL+ L ++ +VG+VFL S E VYKEYC N++ + L+ K N+ + + N + G L L+KP+QR ++YPL L ++ T HPD L A + INE KR ++L D+ K + IH+I KK RV I ++G A Q +D ++E F+ ++ I FI RD L YL ++ T + LV++PLN+LL +F+GP L++KR K +D+ +R + + + Q ++L RN Y A+N L ELP + + +F C+ Y ++ + LK L+ EG+ ++ +E+ + Q ++ F +L S P R +I + ++ + + Q + + + ++ PE L + + + + + + G LVG++K+ +P G WL++ + GFV S+L +P ++ +GS+ S + Y + + + +S + + F+P N
Sbjct: 728 EGAEQTLSTGSTTENSEQRMLEKRSKVIEELLQTEQDYLRDLETCVEHIMGPLQANVDFDVLFGNIQSVIDISKKFLTALGSS-------DSVGTVFLDHASDLENVYKEYCQNHEETIALLEAYDKDEKFQKNLLECMETVKNLYQEWGRTNYINLGSFLIKPVQRIMRYPLLLMELLGATPDSHPDKAPLREAVQSVKDINGNINEYKRRKDLVLKYRKGDENSLIDKISKLN---IHSIIKKSNRVSSHIKQLTGFAPQIKDEAFEETEKNFRMQERLIKSFI------RD---------------------------LSVYLQHVRKQRT----------------EKLVISPLNQLLNMFAGPHKLVQKRFDKLLDFHNCTERAEKLKDKKTQ-EELQSARNNYEALNAQLLDELPKFHNFAKELFASCMRGYASAHCEFVKLALEELKPLLTLLGVGATEGNLIAVFQEEHSKVLQQLQVFTFFPENLPPSKKPFERKTIER----------QSARKTIPSPYIPQLDEHRVAVLARYPPEKLFQADRIYNAAQDLDVSLQEGDLVGVIKQQDPMGSQNRWLIDNGVTK-GFVYCSFLKPYNPRQSHSDASVGSQS-STESGYGGSSPNFSRQNSNNTLTFNPGN 1306
BLAST of Rho guanine nucleotide exchange factor 38 vs. Ensembl Mouse
Match: Dnmbp (dynamin binding protein [Source:MGI Symbol;Acc:MGI:1917352]) HSP 1 Score: 157.532 bits (397), Expect = 9.124e-39 Identity = 158/601 (26.29%), Postives = 285/601 (47.42%), Query Frame = 3
Query: 1461 EKKMQKRSXXXXXXXXXXXXXXQDLKITLEAFDKNLIPTKIPDQDFHLLFGDLKSVIAVAEEFLSKLSANMEDGLDKIAVGSVFLQSVSSFEEVYKEYCVNYDRKLDLINKKSK----ASNVTDFVSDGLNRLNDLGVFAS-TLDMMLVKPLQRFLKYPLFLKTIIENTLPDHPD---INDLIAASSEFDVLAQKINEKKRFEEL----RQITFDR-TEKWHMRTIHAIQKKPKRV---IVSISG-AVQNEDTEYQEIVIKFKELKKCISFFIETVFILRDNLKEILNLYSAITDDFTSIIKSNFGSQLHFYLVACKRGETDY--FKKYYTVANKTCIL------DSLVVNPLNKLLELFSGPALLIKKRQSKYIDYLAMKQRCD---DKETSRVQIDKLDQLRNQYLAINNTLKHELPILISKSSVIFNECIGNYLQLSTSTLQSNILSLKNLI--------EGDQLSTEEEQRNCRNHQNEILAFLQRDLLSFNPQYRNSINKGDXXXXXXXXXXXXXXXXXXVYNQTETDVIKLREKFEPENLARVKKDFVPTKPHQIHICAGTLVGILKRCNPQGHSTSWLVEVCPKRTGFVPRSYL 3155
++ ++KR+K++ E+L+TE+ +I+DL++ +E L ++P+ DF LFG++++VI V+++ L+ L + AVG VFL E Y+ YC N+D + L+ K ++ D+++D + ++ G L L+KP+QR ++YPL L ++ +T HPD + + + A E +V INE KR ++L R+ D EK IH+I KK RV + ++G A Q +D ++E F+ ++ I FI + + +++E ++ +K + + + + +RG D F+K + + + LV+NPLN+LL +F+GP L++KR K +D+ +R + DK+T +++L RN Y A+N+ L ELP + +F CI Y + +Q + L+ L+ EG+ ++ E+ + Q ++ F L P R + Q+E L ++ PE L V+++F + + + G LVG++K+ +P G WLV+ + GFV S+L
Sbjct: 25 QRMLEKRAKVVAELLQTERDYIRDLEMCIERVMVPLQQAQVPNVDFEGLFGNMQTVIKVSKQLLAALEIS-------DAVGPVFLDHRDELEGTYRVYCQNHDEAISLLEMYEKDEKTQKHLQDYLADLKSLYHEWGCTNYINLGSFLIKPVQRIMRYPLLLMELLNSTPESHPDKVPLTNAVLAVKEINV---NINEYKRRKDLVLKYRKGDEDSLMEKISKLNIHSIIKKSSRVSSHLKHLTGFAPQLKDEVFEETEKNFRMQERLIKSFIRDLSLYLQHIRE------------SACVK--VVAAMSIWDLCMERGHHDLEQFEKVHRYISDQLFTRFKERTERLVINPLNQLLNMFTGPYKLVQKRFDKLLDFYNCTERAEKLKDKKT----LEELQSARNNYEALNSQLLDELPKFQQYAQSLFTNCIHGYAEAHCDFVQQALEQLQPLLSLLKATDREGNLIAIFLEEHSRVLQQLQVFTFFPESL----PAPRKPFERKTTDRQSSRKTLLGMPSYML---QSEELRSSLLARYPPEKLFHVQRNFNAAQDLDVSLLEGDLVGVIKKKDPMGSQNRWLVDNGVTK-GFVYSSFL 589
BLAST of Rho guanine nucleotide exchange factor 38 vs. Ensembl Mouse
Match: Dnmbp (dynamin binding protein [Source:MGI Symbol;Acc:MGI:1917352]) HSP 1 Score: 158.303 bits (399), Expect = 1.822e-38 Identity = 160/605 (26.45%), Postives = 289/605 (47.77%), Query Frame = 3
Query: 1461 EKKMQKRSXXXXXXXXXXXXXXQDLKITLEAFDKNLIPTKIPDQDFHLLFGDLKSVIAVAEEFLSKLSANMEDGL---DKIAVGSVFLQSVSSFEEVYKEYCVNYDRKLDLINKKSK----ASNVTDFVSD--GLNRLNDLGVFASTLDMMLVKPLQRFLKYPLFLKTIIENTLPDHPD---INDLIAASSEFDVLAQKINEKKRFEEL----RQITFDR-TEKWHMRTIHAIQKKPKRV---IVSISG-AVQNEDTEYQEIVIKFKELKKCISFFIETVFILRDNLKEILNLYSAITDDFTSIIKSNFGSQLHFYLVACKRGETDY--FKKYYTVANKTCIL------DSLVVNPLNKLLELFSGPALLIKKRQSKYIDYLAMKQRCD---DKETSRVQIDKLDQLRNQYLAINNTLKHELPILISKSSVIFNECIGNYLQLSTSTLQSNILSLKNLI--------EGDQLSTEEEQRNCRNHQNEILAFLQRDLLSFNPQYRNSINKGDXXXXXXXXXXXXXXXXXXVYNQTETDVIKLREKFEPENLARVKKDFVPTKPHQIHICAGTLVGILKRCNPQGHSTSWLVEVCPKRTGFVPRSYL 3155
++ ++KR+K++ E+L+TE+ +I+DL++ +E L ++P+ DF LFG++++VI V+++ L+ L + G+ D + G VFL E Y+ YC N+D + L+ K ++ D+++D G +LG F L+KP+QR ++YPL L ++ +T HPD + + + A E +V INE KR ++L R+ D EK IH+I KK RV + ++G A Q +D ++E F+ ++ I FI + + +++E ++ +K + + + + +RG D F+K + + + LV+NPLN+LL +F+GP L++KR K +D+ +R + DK+T +++L RN Y A+N+ L ELP + +F CI Y + +Q + L+ L+ EG+ ++ E+ + Q ++ F L P R + + + Q+E L ++ PE L V+++F + + + G LVG++K+ +P G WLV+ + GFV S+L
Sbjct: 778 QRMLEKRAKVVAELLQTERDYIRDLEMCIERVMVPLQQAQVPNVDFEGLFGNMQTVIKVSKQLLAALEISDAVGMSSCDCLVPGPVFLDHRDELEGTYRVYCQNHDEAISLLEMYEKDEKTQKHLQDYLADLKGCTNYINLGSF-------LIKPVQRIMRYPLLLMELLNSTPESHPDKVPLTNAVLAVKEINV---NINEYKRRKDLVLKYRKGDEDSLMEKISKLNIHSIIKKSSRVSSHLKHLTGFAPQLKDEVFEETEKNFRMQERLIKSFIRDLSLYLQHIRE------------SACVK--VVAAMSIWDLCMERGHHDLEQFEKVHRYISDQLFTRFKERTERLVINPLNQLLNMFTGPYKLVQKRFDKLLDFYNCTERAEKLKDKKT----LEELQSARNNYEALNSQLLDELPKFQQYAQSLFTNCIHGYAEAHCDFVQQALEQLQPLLSLLKATDREGNLIAIFLEEHSRVLQQLQVFTFFPESL----PAPRKPFER---KTTDRQSSRKTLLGMPSYMLQSEELRSSLLARYPPEKLFHVQRNFNAAQDLDVSLLEGDLVGVIKKKDPMGSQNRWLVDNGVTK-GFVYSSFL 1346
BLAST of Rho guanine nucleotide exchange factor 38 vs. Ensembl Mouse
Match: Dnmbp (dynamin binding protein [Source:MGI Symbol;Acc:MGI:1917352]) HSP 1 Score: 158.303 bits (399), Expect = 1.822e-38 Identity = 160/605 (26.45%), Postives = 289/605 (47.77%), Query Frame = 3
Query: 1461 EKKMQKRSXXXXXXXXXXXXXXQDLKITLEAFDKNLIPTKIPDQDFHLLFGDLKSVIAVAEEFLSKLSANMEDGL---DKIAVGSVFLQSVSSFEEVYKEYCVNYDRKLDLINKKSK----ASNVTDFVSD--GLNRLNDLGVFASTLDMMLVKPLQRFLKYPLFLKTIIENTLPDHPD---INDLIAASSEFDVLAQKINEKKRFEEL----RQITFDR-TEKWHMRTIHAIQKKPKRV---IVSISG-AVQNEDTEYQEIVIKFKELKKCISFFIETVFILRDNLKEILNLYSAITDDFTSIIKSNFGSQLHFYLVACKRGETDY--FKKYYTVANKTCIL------DSLVVNPLNKLLELFSGPALLIKKRQSKYIDYLAMKQRCD---DKETSRVQIDKLDQLRNQYLAINNTLKHELPILISKSSVIFNECIGNYLQLSTSTLQSNILSLKNLI--------EGDQLSTEEEQRNCRNHQNEILAFLQRDLLSFNPQYRNSINKGDXXXXXXXXXXXXXXXXXXVYNQTETDVIKLREKFEPENLARVKKDFVPTKPHQIHICAGTLVGILKRCNPQGHSTSWLVEVCPKRTGFVPRSYL 3155
++ ++KR+K++ E+L+TE+ +I+DL++ +E L ++P+ DF LFG++++VI V+++ L+ L + G+ D + G VFL E Y+ YC N+D + L+ K ++ D+++D G +LG F L+KP+QR ++YPL L ++ +T HPD + + + A E +V INE KR ++L R+ D EK IH+I KK RV + ++G A Q +D ++E F+ ++ I FI + + +++E ++ +K + + + + +RG D F+K + + + LV+NPLN+LL +F+GP L++KR K +D+ +R + DK+T +++L RN Y A+N+ L ELP + +F CI Y + +Q + L+ L+ EG+ ++ E+ + Q ++ F L P R + + + Q+E L ++ PE L V+++F + + + G LVG++K+ +P G WLV+ + GFV S+L
Sbjct: 778 QRMLEKRAKVVAELLQTERDYIRDLEMCIERVMVPLQQAQVPNVDFEGLFGNMQTVIKVSKQLLAALEISDAVGMSSCDCLVPGPVFLDHRDELEGTYRVYCQNHDEAISLLEMYEKDEKTQKHLQDYLADLKGCTNYINLGSF-------LIKPVQRIMRYPLLLMELLNSTPESHPDKVPLTNAVLAVKEINV---NINEYKRRKDLVLKYRKGDEDSLMEKISKLNIHSIIKKSSRVSSHLKHLTGFAPQLKDEVFEETEKNFRMQERLIKSFIRDLSLYLQHIRE------------SACVK--VVAAMSIWDLCMERGHHDLEQFEKVHRYISDQLFTRFKERTERLVINPLNQLLNMFTGPYKLVQKRFDKLLDFYNCTERAEKLKDKKT----LEELQSARNNYEALNSQLLDELPKFQQYAQSLFTNCIHGYAEAHCDFVQQALEQLQPLLSLLKATDREGNLIAIFLEEHSRVLQQLQVFTFFPESL----PAPRKPFER---KTTDRQSSRKTLLGMPSYMLQSEELRSSLLARYPPEKLFHVQRNFNAAQDLDVSLLEGDLVGVIKKKDPMGSQNRWLVDNGVTK-GFVYSSFL 1346
BLAST of Rho guanine nucleotide exchange factor 38 vs. Ensembl Mouse
Match: Dnmbp (dynamin binding protein [Source:MGI Symbol;Acc:MGI:1917352]) HSP 1 Score: 155.992 bits (393), Expect = 9.501e-38 Identity = 158/601 (26.29%), Postives = 287/601 (47.75%), Query Frame = 3
Query: 1461 EKKMQKRSXXXXXXXXXXXXXXQDLKITLEAFDKNLIPTKIPDQDFHLLFGDLKSVIAVAEEFLSKLSANMEDGLDKIAVGSVFLQSVSSFEEVYKEYCVNYDRKLDLINKKSK----ASNVTDFVSDGLNRLNDLGVFAS-TLDMMLVKPLQRFLKYPLFLKTIIENTLPDHPD---INDLIAASSEFDVLAQKINEKKRFEEL----RQITFDR-TEKWHMRTIHAIQKKPKRV---IVSISG-AVQNEDTEYQEIVIKFKELKKCISFFIETVFILRDNLKEILNLYSAITDDFTSIIKSNFGSQLHFYLVACKRGETDY--FKKYYTVANKTCIL------DSLVVNPLNKLLELFSGPALLIKKRQSKYIDYLAMKQRCD---DKETSRVQIDKLDQLRNQYLAINNTLKHELPILISKSSVIFNECIGNYLQLSTSTLQSNILSLKNLI--------EGDQLSTEEEQRNCRNHQNEILAFLQRDLLSFNPQYRNSINKGDXXXXXXXXXXXXXXXXXXVYNQTETDVIKLREKFEPENLARVKKDFVPTKPHQIHICAGTLVGILKRCNPQGHSTSWLVEVCPKRTGFVPRSYL 3155
++ ++KR+K++ E+L+TE+ +I+DL++ +E L ++P+ DF LFG++++VI V+++ L+ L + AVG VFL E Y+ YC N+D + L+ K ++ D+++D + ++ G L L+KP+QR ++YPL L ++ +T HPD + + + A E +V INE KR ++L R+ D EK IH+I KK RV + ++G A Q +D ++E F+ ++ I FI + + +++E ++ +K + + + + +RG D F+K + + + LV+NPLN+LL +F+GP L++KR K +D+ +R + DK+T +++L RN Y A+N+ L ELP + +F CI Y + +Q + L+ L+ EG+ ++ E+ + Q ++ F L P R + + + Q+E L ++ PE L V+++F + + + G LVG++K+ +P G WLV+ + GFV S+L
Sbjct: 778 QRMLEKRAKVVAELLQTERDYIRDLEMCIERVMVPLQQAQVPNVDFEGLFGNMQTVIKVSKQLLAALEIS-------DAVGPVFLDHRDELEGTYRVYCQNHDEAISLLEMYEKDEKTQKHLQDYLADLKSLYHEWGCTNYINLGSFLIKPVQRIMRYPLLLMELLNSTPESHPDKVPLTNAVLAVKEINV---NINEYKRRKDLVLKYRKGDEDSLMEKISKLNIHSIIKKSSRVSSHLKHLTGFAPQLKDEVFEETEKNFRMQERLIKSFIRDLSLYLQHIRE------------SACVK--VVAAMSIWDLCMERGHHDLEQFEKVHRYISDQLFTRFKERTERLVINPLNQLLNMFTGPYKLVQKRFDKLLDFYNCTERAEKLKDKKT----LEELQSARNNYEALNSQLLDELPKFQQYAQSLFTNCIHGYAEAHCDFVQQALEQLQPLLSLLKATDREGNLIAIFLEEHSRVLQQLQVFTFFPESL----PAPRKPFER---KTTDRQSSRKTLLGMPSYMLQSEELRSSLLARYPPEKLFHVQRNFNAAQDLDVSLLEGDLVGVIKKKDPMGSQNRWLVDNGVTK-GFVYSSFL 1342
BLAST of Rho guanine nucleotide exchange factor 38 vs. Ensembl Mouse
Match: Dnmbp (dynamin binding protein [Source:MGI Symbol;Acc:MGI:1917352]) HSP 1 Score: 155.221 bits (391), Expect = 1.435e-37 Identity = 163/604 (26.99%), Postives = 292/604 (48.34%), Query Frame = 3
Query: 1461 EKKMQKRSXXXXXXXXXXXXXXQDLKITLEAFDKNLIPTKIPDQDFHLLFGDLKSVIAVAEEFLSKLSANMEDGLDKIAVGSVFLQSVSSFEEVYKEYCVNYDRKLDLINKKSK----ASNVTDFVSDGLNRLNDLGVFAS-TLDMMLVKPLQRFLKYPLFLKTIIENTLPDHPD---INDLIAASSEFDVLAQKINEKKRFEEL----RQITFDR-TEKWHMRTIHAIQKKPKRV---IVSISG-AVQNEDTEYQEIVIKFKELKKCISFFIETVFILRDNLKEILNLYSAITDDFTSIIKSNFGSQLHFYLVACKRGETDY--FKKYYTVANKTCIL------DSLVVNPLNKLLELFSGPALLIKKRQSKYIDYLAMKQRCD---DKETSRVQIDKLDQLRNQYLAINNTLKHELPILISKSSVIFNECIGNYLQLSTSTLQSNILSLKNLI--------EGDQLST--EEEQRNCRNHQNEILAFLQRDLLSFNPQYRNSINKGDXXXXXXXXXXXXXXXXXXVYN-QTETDVIKLREKFEPENLARVKKDFVPTKPHQIHICAGTLVGILKRCNPQGHSTSWLVEVCPKRTGFVPRSYL 3155
++ ++KR+K++ E+L+TE+ +I+DL++ +E L ++P+ DF LFG++++VI V+++ L+ L + AVG VFL E Y+ YC N+D + L+ K ++ D+++D + ++ G L L+KP+QR ++YPL L ++ +T HPD + + + A E +V INE KR ++L R+ D EK IH+I KK RV + ++G A Q +D ++E F+ ++ I FI + + +++E ++ +K + + + + +RG D F+K + + + LV+NPLN+LL +F+GP L++KR K +D+ +R + DK+T +++L RN Y A+N+ L ELP + +F CI Y + +Q + L+ L+ EG+ ++ EE R +L LQ + +F P+ + K ++ L Y Q+E L ++ PE L V+++F + + + G LVG++K+ +P G WLV+ + GFV S+L
Sbjct: 466 QRMLEKRAKVVAELLQTERDYIRDLEMCIERVMVPLQQAQVPNVDFEGLFGNMQTVIKVSKQLLAALEIS-------DAVGPVFLDHRDELEGTYRVYCQNHDEAISLLEMYEKDEKTQKHLQDYLADLKSLYHEWGCTNYINLGSFLIKPVQRIMRYPLLLMELLNSTPESHPDKVPLTNAVLAVKEINV---NINEYKRRKDLVLKYRKGDEDSLMEKISKLNIHSIIKKSSRVSSHLKHLTGFAPQLKDEVFEETEKNFRMQERLIKSFIRDLSLYLQHIRE------------SACVK--VVAAMSIWDLCMERGHHDLEQFEKVHRYISDQLFTRFKERTERLVINPLNQLLNMFTGPYKLVQKRFDKLLDFYNCTERAEKLKDKKT----LEELQSARNNYEALNSQLLDELPKFQQYAQSLFTNCIHGYAEAHCDFVQQALEQLQPLLSLLKATDREGNLIAIFLEEHSR--------VLQQLQ--VFTFFPESLPAPRKPFERKTTDRQSSRKTLLGMPSYMLQSEELRSSLLARYPPEKLFHVQRNFNAAQDLDVSLLEGDLVGVIKKKDPMGSQNRWLVDNGVTK-GFVYSSFL 1030
BLAST of Rho guanine nucleotide exchange factor 38 vs. UniProt/SwissProt
Match: sp|M0R4F8|DNMBP_RAT (Dynamin-binding protein OS=Rattus norvegicus OX=10116 GN=Dnmbp PE=1 SV=2) HSP 1 Score: 162.54 bits (410), Expect = 6.768e-39 Identity = 162/591 (27.41%), Postives = 280/591 (47.38%), Query Frame = 3
Query: 1461 EKKMQKRSXXXXXXXXXXXXXXQDLKITLEAFDKNLIPTKIPDQDFHLLFGDLKSVIAVAEEFLSKLSANMEDGLDKIAVGSVFLQSVSSFEEVYKEYCVNYDRKLDLINKKSKASNVTDFVSDGLNRLNDL-GVFAST----LDMMLVKPLQRFLKYPLFLKTIIENTLPDHPDINDLIAASSEFDVLAQKINEKKRFEEL----RQITFDR-TEKWHMRTIHAIQKKPKRV---IVSISG-AVQNEDTEYQEIVIKFKELKKCISFFIETVFILRDNLKEILNLYSAITDDFTSIIKSNFGSQLHFYLVACKRGETDY--FKKYYTVANKTCIL------DSLVVNPLNKLLELFSGPALLIKKRQSKYIDYLAMKQRCD---DKETSRVQIDKLDQLRNQYLAINNTLKHELPILISKSSVIFNECIGNYLQLSTSTLQSNILSLKNLIEGDQLSTEEEQRNCRNHQNEILAFLQRDLLSFNPQYRNSINKGDXXXXXXXXXXXXXXXXXXVYN-QTETDVIKLREKFEPENLARVKKDFVPTKPHQIHICAGTLVGILKRCNPQGHSTSWLVEVCPKRTGFVPRSYL 3155
++ ++KR+K++ E+L+TEK +I+DL++ +E L ++P+ DF LFG++++VI V+++ L+ L AVG VFL E Y+ YC N+D + L++ K + + D L L L + T L L+KP+QR ++YPL L ++ +T HPD L +A + INE KR ++L R+ D EK IH+I KK RV + ++G A Q +D ++E F+ ++ I FI + + +++E ++ +K + + + + +RG D F+K + + + LV+NPLN+LL +F+GP L++KR K +D+ +R + DK+T ++ L RN Y A+N+ L ELP + +F CI Y + +Q + L+ L+ + S E H+ Q + +F P+ + K ++ A L Y Q+E L ++ PE L V+++F + + + G LVG++K+ +P G WLV+ + GFV S+L
Sbjct: 779 QRMLEKRAKVVAELLQTEKDYIRDLEMCVERVMVPLQQAQVPNIDFEGLFGNMQTVIKVSKQLLAALEIT-------DAVGPVFLDHRDELEGTYRLYCQNHDEAISLLDIYEKDERIQKHLQDYLADLKSLYHEWGCTNYINLGSFLIKPVQRIMRYPLLLMELLNSTPESHPDKAPLTSAVLAIKEINANINEYKRRKDLVLKYRKADEDSLMEKISKLNIHSIIKKSSRVSSHLKHLTGFAPQLKDEAFEETEKNFRMQERLIKSFIRDLSLYLQHIRE------------SACVK--VVAAMSIWDLCMERGHHDLEQFEKVHRYISDQLFTRFKERTERLVINPLNQLLNMFTGPYKLVQKRFDKLLDFYNCTERAEKLKDKKT----LEDLQSARNNYEALNSQLLDELPKFQQYAQSLFTNCIHGYAEAHCDFVQKALEQLQPLLSLLKASDREGNLIAIFHEEHSRVLQQLQVFTFFPEALPAPRKPFERKTTDRQSSRKALLGMPSYMLQSEELRSSLLARYPPEKLFHVQRNFNAAQDLDVSLLEGDLVGVIKKKDPMGSQNRWLVDNGVTK-GFVYSSFL 1343
BLAST of Rho guanine nucleotide exchange factor 38 vs. UniProt/SwissProt
Match: sp|E2RP94|DNMBP_CANLF (Dynamin-binding protein OS=Canis lupus familiaris OX=9615 GN=DNMBP PE=3 SV=2) HSP 1 Score: 160.229 bits (404), Expect = 3.346e-38 Identity = 161/593 (27.15%), Postives = 281/593 (47.39%), Query Frame = 3
Query: 1461 EKKMQKRSXXXXXXXXXXXXXXQDLKITLEAFDKNLIPTKIPDQDFHLLFGDLKSVIAVAEEFLSKLSANMEDGLDKIAVGSVFLQSVSSFEEVYKEYCVNYDRKLDLINKKSKASNVTDFVSDGLNRLNDLGV-FAST----LDMMLVKPLQRFLKYPLFLKTIIENTLPDHPDINDLIAASSEFDVLAQKINEKKRFEEL----RQITFDR-TEKWHMRTIHAIQKKPKRV---IVSISG-AVQNEDTEYQEIVIKFKELKKCISFFIETVFILRDNLKE--ILNLYSAITDDFTSIIKSNFGSQLHFYLVACKRGETDY--FKKYYTVANKTCIL------DSLVVNPLNKLLELFSGPALLIKKRQSKYIDYLAMKQRCD---DKETSRVQIDKLDQLRNQYLAINNTLKHELPILISKSSVIFNECIGNYLQLSTSTLQSNILSLKNLIEGDQLSTEEEQRNCRNHQNEILAFLQRDLLSFNPQYRNSINKGDXXXXXXXXXXXXXXXXXXVYN-QTETDVIKLREKFEPENLARVKKDFVPTKPHQIHICAGTLVGILKRCNPQGHSTSWLVEVCPKRTGFVPRSYL 3155
++ ++KR+K+IEE+L+TE+ +++DL++ +E L T+IP+ DF LFG+++ VI V+++ L+ L + D AVG VFL E YK YC N+D + L+ K + + D L L L + T L L+KP+QR ++YPL L ++ +T HPD L +A + INE KR ++L R+ D EK IH+I KK RV + ++G A Q +D ++E F+ ++ I FI + + +++E + + +A++ + V ++G D F+K + + + LV++PLN+LL +F+GP L++KR K +D+ +R + DK+T +++L RN Y A+N L ELP + +F CI Y + ++ + LK L+ +++ E H+ Q + +F P+ + K + L Y Q+E L ++ PE L + +++F + + + G LVG++K+ +P G WL++ + GFV S+L
Sbjct: 786 QRMLEKRAKVIEELLQTERDYVRDLEMCIEHIMAPLQQTQIPNIDFEGLFGNMQMVIKVSKQLLADL--EISD-----AVGPVFLDHRDELEGTYKVYCQNHDEAISLLEIYEKDEKIQKHLQDSLADLKSLYTEWGCTNYINLGSFLIKPVQRVMRYPLLLMELLNSTPESHPDKAPLTSAVLAVKEINVNINEYKRRKDLVLKYRKGDEDSLMEKISKLNIHSIIKKSNRVSSHLKHLTGFAPQIKDEAFEETEKNFRMQERLIKSFIRDLSLYLQHIRESACVKVVAAVS----------------MWDVCMEKGHRDLEQFEKVHRYISDQLFTNFKERTERLVISPLNQLLSMFTGPHKLVQKRFDKLLDFYNCTERAEKLKDKKT----LEELQSARNNYEALNAQLLDELPKFHQYAQGLFTNCIHGYAEAHCDFVRQALEQLKPLLSLLKVAGREGNLIAIFHEEHSRVLQQLQVFTFFPESLPAARKPFERKTLDRQSARKPLLGLPSYMLQSEELRASLLTRYPPEKLFQAERNFNAAQDLDVSLLEGDLVGVIKKKDPMGSQNRWLIDNGVSQ-GFVYSSFL 1350
BLAST of Rho guanine nucleotide exchange factor 38 vs. UniProt/SwissProt
Match: sp|Q6TXD4|DNMBP_MOUSE (Dynamin-binding protein OS=Mus musculus OX=10090 GN=Dnmbp PE=1 SV=2) HSP 1 Score: 158.303 bits (399), Expect = 1.296e-37 Identity = 160/605 (26.45%), Postives = 289/605 (47.77%), Query Frame = 3
Query: 1461 EKKMQKRSXXXXXXXXXXXXXXQDLKITLEAFDKNLIPTKIPDQDFHLLFGDLKSVIAVAEEFLSKLSANMEDGL---DKIAVGSVFLQSVSSFEEVYKEYCVNYDRKLDLINKKSK----ASNVTDFVSD--GLNRLNDLGVFASTLDMMLVKPLQRFLKYPLFLKTIIENTLPDHPD---INDLIAASSEFDVLAQKINEKKRFEEL----RQITFDR-TEKWHMRTIHAIQKKPKRV---IVSISG-AVQNEDTEYQEIVIKFKELKKCISFFIETVFILRDNLKEILNLYSAITDDFTSIIKSNFGSQLHFYLVACKRGETDY--FKKYYTVANKTCIL------DSLVVNPLNKLLELFSGPALLIKKRQSKYIDYLAMKQRCD---DKETSRVQIDKLDQLRNQYLAINNTLKHELPILISKSSVIFNECIGNYLQLSTSTLQSNILSLKNLI--------EGDQLSTEEEQRNCRNHQNEILAFLQRDLLSFNPQYRNSINKGDXXXXXXXXXXXXXXXXXXVYNQTETDVIKLREKFEPENLARVKKDFVPTKPHQIHICAGTLVGILKRCNPQGHSTSWLVEVCPKRTGFVPRSYL 3155
++ ++KR+K++ E+L+TE+ +I+DL++ +E L ++P+ DF LFG++++VI V+++ L+ L + G+ D + G VFL E Y+ YC N+D + L+ K ++ D+++D G +LG F L+KP+QR ++YPL L ++ +T HPD + + + A E +V INE KR ++L R+ D EK IH+I KK RV + ++G A Q +D ++E F+ ++ I FI + + +++E ++ +K + + + + +RG D F+K + + + LV+NPLN+LL +F+GP L++KR K +D+ +R + DK+T +++L RN Y A+N+ L ELP + +F CI Y + +Q + L+ L+ EG+ ++ E+ + Q ++ F L P R + + + Q+E L ++ PE L V+++F + + + G LVG++K+ +P G WLV+ + GFV S+L
Sbjct: 778 QRMLEKRAKVVAELLQTERDYIRDLEMCIERVMVPLQQAQVPNVDFEGLFGNMQTVIKVSKQLLAALEISDAVGMSSCDCLVPGPVFLDHRDELEGTYRVYCQNHDEAISLLEMYEKDEKTQKHLQDYLADLKGCTNYINLGSF-------LIKPVQRIMRYPLLLMELLNSTPESHPDKVPLTNAVLAVKEINV---NINEYKRRKDLVLKYRKGDEDSLMEKISKLNIHSIIKKSSRVSSHLKHLTGFAPQLKDEVFEETEKNFRMQERLIKSFIRDLSLYLQHIRE------------SACVK--VVAAMSIWDLCMERGHHDLEQFEKVHRYISDQLFTRFKERTERLVINPLNQLLNMFTGPYKLVQKRFDKLLDFYNCTERAEKLKDKKT----LEELQSARNNYEALNSQLLDELPKFQQYAQSLFTNCIHGYAEAHCDFVQQALEQLQPLLSLLKATDREGNLIAIFLEEHSRVLQQLQVFTFFPESL----PAPRKPFER---KTTDRQSSRKTLLGMPSYMLQSEELRSSLLARYPPEKLFHVQRNFNAAQDLDVSLLEGDLVGVIKKKDPMGSQNRWLVDNGVTK-GFVYSSFL 1346
BLAST of Rho guanine nucleotide exchange factor 38 vs. UniProt/SwissProt
Match: sp|Q6XZF7|DNMBP_HUMAN (Dynamin-binding protein OS=Homo sapiens OX=9606 GN=DNMBP PE=1 SV=1) HSP 1 Score: 154.836 bits (390), Expect = 1.787e-36 Identity = 158/596 (26.51%), Postives = 281/596 (47.15%), Query Frame = 3
Query: 1461 EKKMQKRSXXXXXXXXXXXXXXQDLKITLEAFDKNLIPTKIPDQDFHLLFGDLKSVIAVAEEFLSKLSANMEDGLDKIAVGSVFLQSVSSFEEVYKEYCVNYDRKLDLINKKSKASNVTDFVSDGLNRLNDL-GVFAST----LDMMLVKPLQRFLKYPLFLKTIIENTLPDHPD---INDLIAASSEFDVLAQKINEKKRFEEL----RQITFDR-TEKWHMRTIHAIQKKPKRV---IVSISG-AVQNEDTEYQEIVIKFKELKKCISFFIETVFILRDNLKE--ILNLYSAITDDFTSIIKSNFGSQLHFYLVACKRGETDY--FKKYYTVANKTCIL------DSLVVNPLNKLLELFSGPALLIKKRQSKYIDYLAMKQRCD---DKETSRVQIDKLDQLRNQYLAINNTLKHELPILISKSSVIFNECIGNYLQLSTSTLQSNILSLKNLIEGDQLSTEEEQRNCRNHQNEILAFLQRDLLSFNPQYRNSINKGDXXXXXXXXXXXXXXXXXXVYN-QTETDVIKLREKFEPENLARVKKDFVPTKPHQIHICAGTLVGILKRCNPQGHSTSWLVEVCPKRTGFVPRSYL 3155
++ ++KR+K+IEE+L+TE+ +I+DL++ +E + ++P+ DF LFG+++ VI V+++ L+ L + AVG VFL E YK YC N+D + L+ K + + D L L L + T L L+KP+QR ++YPL L ++ +T HPD + + + A E +V INE KR ++L R+ D EK IH+I KK RV + ++G A Q +D ++E F+ ++ I FI + + +++E + + +A++ + V +RG D F++ + + + LV++PLN+LL +F+GP L++KR K +D+ +R + DK+T +++L RN Y A+N L ELP + +F C+ Y + + + LK L+ +++ E H+ Q + +F P+ + K + L Y Q+E L ++ PE L + +++F + + + G LVG++K+ +P G WL++ + GFV S+L
Sbjct: 779 QRMLEKRAKVIEELLQTERDYIRDLEMCIERIMVPMQQAQVPNIDFEGLFGNMQMVIKVSKQLLAALEIS-------DAVGPVFLGHRDELEGTYKIYCQNHDEAIALLEIYEKDEKIQKHLQDSLADLKSLYNEWGCTNYINLGSFLIKPVQRVMRYPLLLMELLNSTPESHPDKVPLTNAVLAVKEINV---NINEYKRRKDLVLKYRKGDEDSLMEKISKLNIHSIIKKSNRVSSHLKHLTGFAPQIKDEVFEETEKNFRMQERLIKSFIRDLSLYLQHIRESACVKVVAAVS----------------MWDVCMERGHRDLEQFERVHRYISDQLFTNFKERTERLVISPLNQLLSMFTGPHKLVQKRFDKLLDFYNCTERAEKLKDKKT----LEELQSARNNYEALNAQLLDELPKFHQYAQGLFTNCVHGYAEAHCDFVHQALEQLKPLLSLLKVAGREGNLIAIFHEEHSRVLQQLQVFTFFPESLPATKKPFERKTIDRQSARKPLLGLPSYMLQSEELRASLLARYPPEKLFQAERNFNAAQDLDVSLLEGDLVGVIKKKDPMGSQNRWLIDNGVTK-GFVYSSFL 1343
BLAST of Rho guanine nucleotide exchange factor 38 vs. UniProt/SwissProt
Match: sp|E7F1U2|DNMBP_DANRE (Dynamin-binding protein OS=Danio rerio OX=7955 GN=dnmbp PE=2 SV=1) HSP 1 Score: 150.599 bits (379), Expect = 3.175e-35 Identity = 145/568 (25.53%), Postives = 254/568 (44.72%), Query Frame = 3
Query: 1527 QDLKITLEAFDKNLIPTKIPDQDFHLLFGDLKSVIAVAEEFLSKLSANMEDGLDKIAVGSVFLQSVSSFEEVYKEYCVNYDRKLDLINKKSKASNVTDFVSDGLNRLNDLGVFAS-------TLDMMLVKPLQRFLKYPLFLKTIIENTLPDHPDINDLIAASSEFDVLAQKINEKKRFEEL----RQITFDR-TEKWHMRTIHAIQKKPKRV---IVSISG-AVQNEDTEYQEIVIKFKELKKCISFFIETVFILRDNLKEILNLYSAITDDFTSIIKSNFGSQLHFYLVACKRGETDYFKKYYTVANKTCILDSLVVNPLNKLLELFSGPALLIKKRQSKYIDYLAMKQRCDDKETSRVQIDKLDQLRNQYLAINNTLKHELPILISKSSVIFNECIGNYLQLSTSTLQSNILSLKNLI--------EGDQLSTEEEQRNCRNHQNEILAFLQRDLLSFNPQ-YRNSINKGDXXXXXXXXXXXXXXXXXXVYNQTETDVIKLREKFEPENLARVKKDFVPTKPHQIHICAGTLVGILKRCNPQGHSTSWLVEVCPKRTGFVPRSYL 3155
+DL++ ++ + L ++ DF LFG++ SVI ++ L D ++G VFL E+VYK YC N+D + L+ K N+ V + L +L G++ L L+KP+QR ++YPL L ++ T H D L A + INE KR ++L R+ DR +K ++H+I KK RV + ++G + Q +D + + +F+ ++ I FI + + +++E ++ F I R +D K++ +T ++LV+ PL +LL +F+GP LI+KR+ K +DY K+R + + RVQ ++L RN Y A+N L ELP + +F C+ ++Q + + L L+ EG+ +S +E+ +L LQ SF P+ ++ K QT+ L ++ PENL + +++F + + + G +VG++K+ +P G WL++ + GFV S+L
Sbjct: 867 KDLQMCVKEIIQPLQKKQVQGIDFDGLFGNISSVIDLSRRLNKTLQ-------DTDSIGQVFLSYKDQLEDVYKIYCQNHDDAISLLETYEKDENIQKHVLECLEKLR--GIYREWGKTNYINLGSFLIKPVQRVMRYPLLLMELLNTTPESHHDRQQLSEAVMSIKEINVNINEYKRRKDLVVKYRKGDEDRLIDKISKLSMHSIIKKSNRVSSHLKHLTGISPQIKDEAFDDAEKRFRLQERLIKSFIRNISLYLQHIRESASVKVLAAISFCDIYTERQQQMDPERFQRAHRCISD--KQFTEFKERT---EALVITPLTQLLNMFTGPHKLIQKRRDKLLDYDNCKERAERLKDKRVQ-EELQTARNNYEALNAQLLDELPKFHRAAEDLFTSCVRGFVQAQRDFISLTLGELTPLLQLSGLGGTEGNLVSLFQEE------HTRVLDLLQS--FSFFPENLPTTVRKTFEKKTLEKQYTKKPQAPPNYVLQTDEHRAGLLVRYGPENLYQAERNFNAAQDLDVSVLEGDIVGVIKQQDPMGSQNRWLIDNGVTK-GFVYSSFL 1410
BLAST of Rho guanine nucleotide exchange factor 38 vs. TrEMBL
Match: A0A1S3HMN3 (dynamin-binding protein OS=Lingula unguis OX=7574 GN=LOC106156567 PE=4 SV=1) HSP 1 Score: 206.838 bits (525), Expect = 4.321e-50 Identity = 191/718 (26.60%), Postives = 339/718 (47.21%), Query Frame = 3
Query: 1527 QDLKITLEAFDKNLIPT--KIPDQDFHLLFGDLKSVIAVAEEFLSKL--SANMEDGLDKIAVGSVFLQSVSSFEEVYKEYCVNYDRKLDLINKKSKASNVTDFVSDGLNRLND-LGVFASTLDMMLVKPLQRFLKYPLFLKTIIENTLPDHPDINDLIAASSEFDVLAQKINEKKRFEEL-----RQITFDRTEKWHMRTIHAIQKKPKRVIVSISG----AVQNEDTEYQEIVIKFKELKKCISFFIETVFILRDNLKEILNLYSAITDDFTSIIKSNFGSQ-LHFYLVACKR-GETDYFKKYYTVANKTCILDSLVVNPLNKLLELFSGPALLIKKRQSKYIDY---LAMKQRCDDKETSRVQIDKLDQLRNQYLAINNTLKHELPILISKSSVIFNECIGNYLQLSTSTLQSNILSLKNLIEGDQL-STEEEQRNCRNHQNEILAFLQRDLLSFNPQYRNSI--NKGDXXXXXXXXXXXXXXXXXXVYNQTETDVIKLREKFEPENLARVKKDFVPTKPHQIHICAGTLVGILKRCNPQGHSTSWLVEVCPKRTGFVPRSYLTLSPFAANKVDLIGSKVISGNATYLNNRHSITADSSF--DLMQFSPNN-------HDDTLRQI----SMVEISPVK---------TRPRAFSTANIIRIALFPHQSRGESEISMQKNDQLEILESPDKSNSRNWSLAKNLRTGAQGYVPTNYL 3548
+DL++ +EAF L P K+ D D LFG+++ V +++ LS+L + N ++ +++ +G+ F+Q + VY YC N+D L L+ K ++ D+ + GL ++ VF L +L+KP+QR LKYPL L ++++T HPD L+ A + +A INE KR ++L ++ ++K +IH+I KK R+ + ++ + Q +D ++ + I+F+ L+K I F+ V D ++E + + +D + + N Q + Y A + G+ F V + I PLNKLL +F GP +I+KR K +DY A + D++ ++ D+L + +N Y A+N L ELP L + S +FNECIG+++Q ++ + + L+E + T E +Q + Q LSF P+ +S +K D L ++ V +QTE+ + +R+++ + L V + I + G +VG++K +P G+ W V+ + GFVP + +L+PFA+ ++ Y + + SF DLM+ SP +D L ++ M E + T P + A + ++R +EIS+++ + +L+ D+ + +W + G QGY P NYL
Sbjct: 879 KDLQLCVEAF---LSPASEKMKDVDMETLFGNIEEVANLSQRMLSQLERAVNGKEFYEQV-LGNCFVQIAEDMKHVYALYCRNHDDVLALLEKCESQQDIQDYFNRGLEKVRQHTTVF--DLGSLLIKPVQRILKYPLLLNELLKSTEDSHPDKFPLLTAINAMTDVATAINEYKRRKDLVYKYRKEADSKLSDKISRLSIHSIMKKSNRLSMKLTSNLGLSSQTKDQQFNKEEIRFRNLEKAIKLFVRNVGQYIDQIQESVGCQETMAEDISDLYAENNSCQEVQQYRAAFRMLGDESIFTFKSHVERRVTI-------PLNKLLSMFHGPLNVIQKRDDKLLDYDSWAAKVKSTKDQDRLKMSKDQLQKAKNNYEALNAQLLDELPKLSNMSLQLFNECIGSFVQAHKVFIEGTLRHMYPLMELPIMNGTGGENVLGMFNQAHVEVVDQLADLSFVPKGFSSRKDSKPDVKLKRLPSDSKFYQELPAVSSQTESQRMSVRQQYPSDKLYTVTQTQSSRDAMSISLAEGDIVGVIKEQDPMGNKDKWFVDNGAIK-GFVPSN--SLAPFAS-------------SSPYPSPERPRASTPSFPTDLMELSPTQPSMKRQESEDFLSELDKFSDMYEQYEKEHEAQGYEGYTNPTLSAQVPQYYYAQYQFEARNSNEISLREGQPVTVLQKYDEQGNPDWWMVD--IDGVQGYAPANYL 1565
BLAST of Rho guanine nucleotide exchange factor 38 vs. TrEMBL
Match: K7JLL0 (Uncharacterized protein OS=Nasonia vitripennis OX=7425 GN=100677917 PE=4 SV=1) HSP 1 Score: 186.808 bits (473), Expect = 3.660e-44 Identity = 193/715 (26.99%), Postives = 321/715 (44.90%), Query Frame = 3
Query: 1527 QDLKITLEAFDKN----LIPTKIPDQDFHLLFGDLKSVIAVAEEFLSKLSANMEDGL--DKIAVGSVFLQSVSSFEEVYKEYCVNYDRKLDLINKKSKASNVTDFVSDGLNRLNDLGVFASTLDMMLVKPLQRFLKYPLFLKTIIENTLPDHPDINDLIAASSEFDVLAQKINEKKRFEEL--RQITFDRTEKWHMRTI--HAIQKKPKRVIVSISGAVQNE----DTEYQEIVIKFKELKKCISFFIETVFILRDNLKEILNLYSAITDDFTSIIKSNFGSQLHFYLVACKRGET-------DYFKKYYTVANKTCILDSLVVNPLNKLLELFSGPALLIKKRQSKYIDYLAMKQRCDDKETSRVQIDKLDQLRNQYLAINNTLKHELPILISKSSVIFNECIG---NYLQLSTSTLQSNILSLKNLIEGDQLSTEEEQRNCRNHQNEILAFLQRDLLSFNPQYRNSINKGDXXXXXXXXXXXXXXXXXXVYNQTETDVIKLREKFEPENLARVKKDFVPTKPHQIHICAGTLVGILKRCNPQGHSTSWLVEVCPKRTGFVPRSYLTLSPFAA------------NKVDLIG--SKVISGNATYLNNRHSITADSSFDLMQFSPNNHDDTLRQISMVEISPVKTRPRAFSTANIIRIALFP-HQSRGESEISMQKNDQLEILESPDKSNSRNWSLAKNLRTGAQGYVPTNYLSK 3554
+DLK+T E F + L KI D LFG++ +I VAEE L + M+ G+ D ++G FL+ Y++YC N++ L L+ K ++ + G+ L + V + +L+KP+QR LKYPL L +++ T HPD + AS +A INE KR ++L + + + T M + H++ KK R+ +S + D +++E+V F L+K F++ V D + L+ + + T QLH Y + E + Y K+CI + V++PLN L+ L SGP LLI KR K +DY D + R + + + ++ + A+N L ELP+ I S+ I CIG N +L + +++ +++ Q S E+ + H + + + R LS+ N+ + D L Q+E ++EK+ P L + + PH + GTLVG++K NP G ++ W V+ + GFV YL +S A + VDL+ S V N Y + S+ +D S DL P N+++ + +I+P + R + AL+ + +S+++ L++LE D+ N+ +W L ++ RTG +GYVP NYL K
Sbjct: 510 RDLKMTYETFHLHNPAFLESRKI---DVTTLFGNISQIIEVAEELLELIQRAMK-GINEDYQSIGPCFLKMSEKMRVAYEKYCSNHEASLALLQKYKDNEDIMRIFNKGVETLR-VQVHCFDMSSVLIKPVQRILKYPLLLDGLLKCTEDGHPDKPKIEEASKVMADVASYINEYKRKKDLASKYLHSNNTLIGKMANLNMHSVAKKSSRLSAKLSATLGLTNLPIDPKFEELVKDFLSLEKSTKQFLKDV----DQCIQWLDAETYCGEVLT--------EQLHQYYTGVRSDEVWRLREVRQIIRSQYIKDFKSCI-ERRVISPLNALISLLSGPELLINKRHDKMLDY-------DTAISRRDKAEDISSAKSNFEALNQQLLEELPVFIQASTAILYNCIGAFTNARKLYNGKILKKYMNISEVVK--QFSLEDIYESYFVHHHSLYNEITR--LSYGGT--NARVEKDSVDYCL---------------QSEVHKKAVKEKYPPNKLYILTRSITGPTPHDLSATKGTLVGVIKTMNPMGDTSKWFVDNGSMK-GFVESQYLEISDEAKLIEESAAAVSMDSSVDLMSLDSPVKEAN-RYSADIQSLYSDVSDDLD--PPPNYEN------LDDITPKEPRQLYENIHEKFVYALYEFNHPELAGTLSVKEGQALKVLEKHDQKNNPDWWLVED-RTGGKGYVPENYLGK 1167
BLAST of Rho guanine nucleotide exchange factor 38 vs. TrEMBL
Match: A0A232EUH7 (Uncharacterized protein OS=Trichomalopsis sarcophagae OX=543379 GN=TSAR_006757 PE=4 SV=1) HSP 1 Score: 186.422 bits (472), Expect = 5.888e-44 Identity = 194/715 (27.13%), Postives = 319/715 (44.62%), Query Frame = 3
Query: 1527 QDLKITLEAFDKN----LIPTKIPDQDFHLLFGDLKSVIAVAEEFLSKLSANMEDGLDK--IAVGSVFLQSVSSFEEVYKEYCVNYDRKLDLINKKSKASNVTDFVSDGLNRLNDLGVFASTLDMMLVKPLQRFLKYPLFLKTIIENTLPDHPDINDLIAASSEFDVLAQKINEKKRFEEL--RQITFDRTEKWHMRTI--HAIQKKPKRVIVSISGAVQNE----DTEYQEIVIKFKELKKCISFFIETVFILRDNLKEILNLYSAITDDFTSIIKSNFGSQLHFYLVACKRGET-------DYFKKYYTVANKTCILDSLVVNPLNKLLELFSGPALLIKKRQSKYIDYLAMKQRCDDKETSRVQIDKLDQLRNQYLAINNTLKHELPILISKSSVIFNECIG---NYLQLSTSTLQSNILSLKNLIEGDQLSTEEEQRNCRNHQNEILAFLQRDLLSFNPQYRNSINKGDXXXXXXXXXXXXXXXXXXVYNQTETDVIKLREKFEPENLARVKKDFVPTKPHQIHICAGTLVGILKRCNPQGHSTSWLVEVCPKRTGFVPRSYLTLSPFAA------------NKVDLIG--SKVISGNATYLNNRHSITADSSFDLMQFSPNNHDDTLRQISMVEISPVKTRPRAFSTANIIRIALFP-HQSRGESEISMQKNDQLEILESPDKSNSRNWSLAKNLRTGAQGYVPTNYLSK 3554
+DLK+T E F + L KI D LFG++ +I VAEE L + M+ G+D+ ++G FL+ Y +YC N++ L L+ K ++ + G+ L + V + +L+KP+QR LKYPL L +++ T HPD + AS +A INE KR ++L + + + T M + H++ KK R+ +S + D +++E+V F L+K F LK++ + D + QLH Y + E + Y K+CI + V++PLN L+ L SGP LLI KR K +DY D + R + + + ++ + A+N L ELP+ I S+ I CIG N +L + +++ +++ QLS E+ + H + L + Q LS+ N+ + D L Q+E +REK+ P L + + PH + GTLVG++K +P G ++ W V+ + GFV YL +S A + VDL+ S V N Y + S+ +D S DL P N+++ + +I+P + R + AL+ + +S+++ L++LE D+ N+ +W L ++ RTG +GYVP NYL K
Sbjct: 510 RDLKMTYETFHLHNPAFLESRKI---DVATLFGNISQIIEVAEELLELIQRAMK-GIDEDYQSIGPCFLKMSEKMRVAYGKYCSNHEASLALLQKYEDNEDIMRIFNKGVETLR-VQVHCFDMSSVLIKPVQRILKYPLLLDGLLKCTEDGHPDKPKIEEASKVMADVASYINEYKRKKDLASKYLHSNNTLIGKMANLNMHSVAKKSSRLSAKLSATLGLTNLPIDPKFEELVKDFLSLEKSTKQF----------LKDVEQCIQCL--DAETYCGEVLTEQLHQYYTGVRSDEVWRLREVRQIIRSQYIKDFKSCI-ERRVISPLNALISLLSGPELLINKRHDKMLDY-------DTAISRRDRAEDISSAKSNFEALNQQLLEELPVFIQASTAILYNCIGAFTNARKLYNGKILKKYMNISEVVK--QLSLEDIYESYFVHHH--LLYNQITRLSYGGT--NARVEKDSVDYCL---------------QSEVHKKAVREKYPPNKLYILTRSITGPTPHDLSATKGTLVGVIKTMDPMGDTSKWFVDNGSMK-GFVESQYLEISDEAKLIEESAAAVSIDSSVDLMSLDSPVKEAN-RYSADIQSLYSDVSDDLD--PPPNYEN------LDDITPKEPRQLYENIHEEFVYALYEFNHPELVGTLSVKEGQALKVLEKHDQKNNPDWWLVED-RTGGKGYVPENYLGK 1167
BLAST of Rho guanine nucleotide exchange factor 38 vs. TrEMBL
Match: A0A4W6C553 (Dynamin binding protein OS=Lates calcarifer OX=8187 PE=4 SV=1) HSP 1 Score: 176.022 bits (445), Expect = 1.642e-41 Identity = 204/752 (27.13%), Postives = 344/752 (45.74%), Query Frame = 3
Query: 1464 KKMQKRSXXXXXXXXXXXXXXQDLKITLEAFDKNLIPTKIPDQDFHLLFGDLKSVIAVAEEFLSKLSANMEDGLDKIAVGSVFLQSVSSFEEVYKEYCVNYDRKLDLINKKSKASNVTDFVSDGLNRLN----DLG-VFASTLDMMLVKPLQRFLKYPLFLKTIIENTLPDH---PDINDLIAASSEFDVLAQKINEKKRFEEL-------RQITF-DRTEKWHMRTIHAIQKKPKRV---IVSISG-AVQNEDTEYQEIVIKFKELKKCISFFIETVFILRDNLKEILNLYSAITDDFTSIIKSNFGSQLHFYLVACKRGETDYFKKYYTVANKTCILDSLVVNPLNKLLELFSGPALLIKKRQSKYIDYLAMKQRCDDKETSRVQIDKLDQLRNQYLAINNTLKHELPILISKSSVIFNECIGNYLQLSTSTLQSNILSLKNLIE-GDQLSTEEEQ-RNCRNHQNEILAFLQRDLLSFNPQ----YRNSINKGDXXXXXXXXXXXXXXXXXXVYNQTETDVIKLREKFEPENLARVKKDFVPTKPHQIHICAGTLVGILKRCNPQGHSTSWLVEVCPKRTGFVPRSYL------------TLSPFAANKVDLIGSKVI----SGNATYLNNRHSITADSSFDLMQFSPNNHDDTLRQISMVEISPVKTRPRAFSTANIIR-------------IALFPHQSRGESEISMQKNDQLEILESPDKSNSRNWSLAKNLRTGAQGYVPTNYLSK 3554
+ ++KRSK+IEE+L+TEK +I+DL++ ++ + L ++ + DF LFG++ SVI +++ L + ++G VFL + EEVYK YC N+D + L+ K N+ V + L+RL D G L L+KP+QR ++YPL L ++ T H P + + + A E +V INE KR ++L + TF D+ K M H+I KK RV + ++G + Q +D + E KF+ ++ I FI + + +++E ++ F I + A R +D K++ +T ++LV+NPL +LL +F+GP LI+KR K +DY K+R D + RVQ ++L RN Y A+N L ELP S + +F C+ + Q +++ + LK L++ ++STE + +L LQ SF P+ + + + + QTE L ++ PE L + +++F + + I G LVG++K+ +P G WL++ + GFV S+L ++ ++N+ GS + + N+T N+ + T S Q + H S P + S +N I AL+ +R +E+S+ N +L ILE D + + W L + G +GYVP+NY+ K
Sbjct: 33 RMLEKRSKVIEELLQTEKDYIKDLQMCVKEIIEPLRKKQVKNVDFDGLFGNINSVIDLSQRLFDTLH-------ETDSIGKVFLDFKTELEEVYKIYCQNHDDAISLLESYEKDENIQRHVLECLDRLRAIYRDWGKTNYINLGSFLIKPVQRVMRYPLLLMELLGATPESHHDRPQLTEALQAVKEINV---NINEYKRRKDLVVKYRKGDEDTFIDKISKLSM---HSIIKKSNRVSSHLKHLTGISPQIKDEAFDEAEKKFRLQERLIKSFIRNISLYLQHIRESASVKVLAAISFCDIYTERSMLDPERFQRA-HRCISD--KQFTQFKERT---ETLVINPLTQLLLMFAGPHKLIQKRFDKLLDYDNCKERADRLKDRRVQ-EELQVARNNYEALNAQLLDELPKFHSAAEELFTGCVTAFAQAQKDFMKTTLGELKPLLQFSSKVSTEGNLIAQFQEEYGRVLQLLQS--FSFCPENLPPATTTKKPFERKTLEKQTSKKQLQGPPNCVVQTEEHRAGLLVRYGPEKLFQAERNFNAAQDLDVSIQEGDLVGVIKQQDPMGSHNRWLIDNGVTK-GFVYSSFLKPYNPRRSQSDVSIESQSSNESGYGGSSPVFSRQNSNSTLTFNQETATVSFSTSQAQNHSSPHPSLDSASSRRSHHRDVPNPDSASQSNSINSSYCFVFVFFQIYYALYSFNARCPNELSISANQRLRILEFQDMNGNSEWWLGEA--GGRRGYVPSNYIRK 759
BLAST of Rho guanine nucleotide exchange factor 38 vs. TrEMBL
Match: A0A195DVB3 (Dynamin-binding protein OS=Trachymyrmex cornetzi OX=471704 GN=ALC57_11228 PE=4 SV=1) HSP 1 Score: 168.703 bits (426), Expect = 1.647e-38 Identity = 177/707 (25.04%), Postives = 304/707 (43.00%), Query Frame = 3
Query: 1527 QDLKITLEAFDKNLIPTKIPDQ--DFHLLFGDLKSVIAVAEEFLSKLSANMEDGLDK--IAVGSVFLQSVSSFEEVYKEYCVNYDRKLDLINKKSKASNVTDFVSDGLNRLNDLGVFASTLDMMLVKPLQRFLKYPLFLKTIIENTLPDHPDINDLIAASSEFDVLAQKINEKKRFEELRQITFDRT----EKWHMRTIHAIQKKPKRVIVSISGAVQ----NEDTEYQEIVIKFKELKKCISFFIETVFILRDNLKEILNLYSAITDDFTSIIKSNFGSQLHFYLVACKRGETDYFKKYYTVANKTCILD------SLVVNPLNKLLELFSGPALLIKKRQSKYIDYLAMKQRCDDKETSRVQIDKLDQLRNQYLAINNTLKHELPILISKSSVIFNECIGNYL---QLSTSTLQSNILSLKNLIEGDQLSTEEEQRNCRNHQNEILAFLQRDLLSFNPQYRNSINKGDXXXXXXXXXXXXXXXXXXVYNQTETDVIKLREKFEPENLARVKKDFVPTKPHQIHICAGTLVGILKRCNPQGHSTSWLVEVCPKRTGFVPRSYLTLSPFAANKVDLIGSKVISGNATYLNNRHSITADS-SFDLMQFSPNNHDDTLRQISMVEI----SPVKTRPRAFSTANIIRI------ALFPHQSRGESEISMQKNDQLEILESPDKSNSRNWSLAKNLRTGAQGYVPTNYLS 3551
+DLK+T E F+ + P+ + + D LFG++ VI VAEE L + M+ G D+ VG F++ + VY +YC N++ L L+ K + + G+ L V + +L+KP+QR +KYPL L +I+ T +HPD ++ A +A INE KR ++ D K ++H++ K R+ +S ++ DTE++E+ +F+ ++KC + K+I + ++D+ +I L Y E + + +V I D V PL+ L L GPA+L+ KR K +DY A + + + S++ ++L ++ Y A+N L ELPIL+ ++ I CI + +L + + +SL LS+++ + + N I + R + I++G + QTE LREK+ + L V +D T ++ GTL+G++K+ +P G+S W V+ + GF+P L + D S V + + + ++ DS ++ + S ++ D L ++ S V PR NI I A++ + + L +L D+ + W L +N R G QGYVP NYLS
Sbjct: 524 RDLKLTYETFNLHK-PSFLESKGIDVATLFGNILEVIHVAEELLDMILRAMK-GCDENLQTVGPCFVKMAEKLKSVYVKYCGNHEAALALLKKYESNEEIMKVFNKGIETLRR-QVACFDMSSILIKPIQRIVKYPLMLYELIKCTEDNHPDKAAIMEAWEAMTNVASYINEYKRRRDIVSKYLDNDNTLFSKMSKLSMHSVAKMSTRLSTRLSASLGLTNVASDTEFEELEKQFRSIEKCTWQLV----------KDIEQCITYLSDE--AISGEAIAELLVHYYQGSPTAEVNKLQDIRSVIWSQYIQDFKSYIEKTVSAPLHFLATLLEGPAMLVSKRHDKLLDYDAAISKSEKYKESKIIQEELFTAKSNYEALNQQLLEELPILLDAAANILVNCINAFAGARKLLSGKITKQYISLCETT--PHLSSQDVLESFLVNHNLIWNQITRFAFAGT---NTRIDEGQ----------------TQLSKQTEEQRSSLREKYTADKLYVVIEDIASTSTLEVDATRGTLIGVIKKQDPMGNSARWYVDTGVTQ-GFLPSQKLRPVQRQSQHHDQTTSDVAAAGRKSASPPNLMSLDSPEKEIKKVSSSHLQDLLSLDQETKVYHNYSNVPETPRVQVYQNIQYIHSEFYYAMYDFAGNMPGTLPITNGQALRLLRPHDEKGNDEWWLVEN-RNGKQGYVPRNYLS 1192
BLAST of Rho guanine nucleotide exchange factor 38 vs. Ensembl Cavefish
Match: dnmbp (dynamin binding protein [Source:NCBI gene;Acc:100005174]) HSP 1 Score: 142.124 bits (357), Expect = 1.426e-33 Identity = 151/568 (26.58%), Postives = 258/568 (45.42%), Query Frame = 3
Query: 1527 QDLKITLEAFDKNLIPTKIPDQDFHLLFGDLKSVIAVAEEFLSKLSANMEDGLDKIAVGSVFLQSVSSFEEVYKEYCVNYDRKLDLINKKSKASNVTDFVSDGLNRLNDL-GVFAST----LDMMLVKPLQRFLKYPLFLKTIIENTLPDHPDINDLIAASSEFDVLAQKINEKKRFEEL----RQITFDR-TEKWHMRTIHAIQKKPKRV---IVSISG-AVQNEDTEYQEIVIKFKELKKCISFFIETVFILRDNLKEI--LNLYSAITDDFTSIIKSNFGSQLHFYLVACKRGETDYFKKYYTVANKTCILDSLVVNPLNKLLELFSGPALLIKKRQSKYIDYLAMKQRCDDKETSRVQIDKLDQLRNQYLAINNTLKHELPILISKSSVIFNECIGNYLQLSTSTLQSNILSLKNLI--------EGDQLSTEEEQRNCRNHQNEILAFLQRDLLSFNPQYRNSINKGDXXXXXXXXXXXXXXXXXXVYN-QTETDVIKLREKFEPENLARVKKDFVPTKPHQIHICAGTLVGILKRCNPQGHSTSWLVEVCPKRTGFVPRSYL 3155
+DL++ + + L ++ + DF LFG++ SVI +++ L D ++G VFL S EEVYK YC N+D + L+ K ++ V + L L + + T L L+KP+QR ++YPL L ++ T H D L A + INE KR ++L R+ DR +K ++H+I KK RV + ++G + Q +D + + +F+ ++ I FI + + +++E + + SAI+ F I R +D K++ +T ++LV++PL +LL +F+GP LI+KR K +DY K+R D + RVQ ++L RN Y A+N L ELP + +F C+ + Q ++ + L L+ EG +S +E+ +L LQ SF P+ + K + Y QT+ L ++ PE L + +++F + + I G +VG++K+ +P G WL++ + GFV S+L
Sbjct: 664 KDLRMCRKEIIEPLRKRQVQNIDFDGLFGNIDSVIHLSQRLNETLQ-------DTDSIGQVFLDFKSELEEVYKVYCQNHDDAISLLETYEKDESIQKHVLECLENLRAIYRGWGKTNYINLGSFLIKPVQRVMRYPLLLMELLNATPQSHHDRKQLEDAVLSVKEINGNINEYKRRKDLVVKYRKGDEDRLIDKISKLSMHSIIKKSNRVSSHLKHLTGISPQIKDEAFDDAEKRFRLQERLIKSFIRDISLYLQHIRESASVKVLSAIS--FCDIYTERQQQLDPERFQRAHRCISD--KQFTQFKERT---ETLVISPLTQLLSMFAGPHKLIQKRFDKLLDYDNCKERADRLKDKRVQ-EELQVARNNYEALNAQLLDELPKFHYAAEELFTSCVRGFAQAQKDFIRLTLGELTPLLQLSGLGGTEGTLVSLFQEE------HGRVLQLLQ--SFSFFPENLPTSRKPFEKKTLEKQTSKKHMQGPPNYVLQTDDHRAGLLARYGPEKLFQAERNFNAAQDLDVSILEGDIVGVIKQQDPMGSQNRWLIDNGATK-GFVYSSFL 1207
BLAST of Rho guanine nucleotide exchange factor 38 vs. Ensembl Cavefish
Match: arhgef38 (Rho guanine nucleotide exchange factor (GEF) 38 [Source:ZFIN;Acc:ZDB-GENE-090313-83]) HSP 1 Score: 138.658 bits (348), Expect = 4.138e-33 Identity = 179/719 (24.90%), Postives = 323/719 (44.92%), Query Frame = 3
Query: 1455 ILEKKMQKRSXXXXXXXXXXXXXXQDLKITLEAFDKNLIPTKIPDQDFHLLFGDLKSVIAVAEEFLSKLS-ANMEDGLDKIAVGSVFLQSVSSFEEVYKEYCVNYDRKLDLINKKSKASNVTDFVSDGLNRLNDLGVFASTLDM--MLVKPLQRFLKYPLFLKTIIENTLPDHPDINDLIAASSEFDVLAQKINEKKRFEEL----RQITFDRTEKWHMR--TIHAIQKKPKRV------IVSISGAVQNEDTEYQEIVIKFKELKKCISFFIETVFILRDNLKEILNLYSAITDDFTSIIKSNFGSQLHFYLVACKRGETDYFKKYYTVANKTCILDSLVVNPLNKLLELFSGPALLIKKRQSKYIDYLAMKQRCDDKETSRVQIDKLDQLRNQYLAINNTLKHELPILISKSSVIFNECIGNYLQLSTSTLQSNILSLKNLIEGDQ---LSTEEEQRNCRNHQNEILAFLQRDLLSFNPQYRNSINKGDXXXXXXXXXXXXXXXXXXVYNQTETDVIKLREKFEPENLARVKKDFVPTKPHQIHICAGTLVGILKRCNPQGHSTSWLVEVCPKRT-GFVPRSYLTLSPFAANKVDLIGSKVISGNATYLNNRHSITADSSFDLMQFSPNNHDDTLRQISMVEISPVKTRPRAFSTANIIRIALFPHQSRGESEISMQKNDQLEILESPDKSNSRNWSLAKNLRTGAQGYVPTNYLSK 3554
+ ++KM KR K+IEE++ TE ++ DL++ + + L T++ D LF +++ V AV+ E L +L A E + +G VF+Q+ ++ EEVYK YC ++D L+ ++ + ++ L + LDM +++KP+QR +KYPL L + + T PDHPD + L A + ++ INE KR +++ ++ ++ + K + IH ++KK +R+ + + V++E + +E + F+ L+K + ++ + +L LY+ + + L+F +R D +K+ L+ ++V PL L +FS P LI+KR K + + + E S ++L LR+ Y A+N L EL ++ I C+ LST L L+ L+E + L N QN I+ + LSF R S K S V Q+E D ++ + + L ++K++ + + + G LV +L+ +P G S+ W V+ + T G+V S+L KV V G+ + N ++ S L F+ + +P T+ + + A A++ Q+R + E+++Q+ + IL+ D ++ W LA+ G +GYVP NYL +
Sbjct: 41 VRQRKMMKREKVIEELVRTEGDYLTDLELCIREVLQPLRNTQV---DVDRLFTNMECVCAVSGELLHRLQEAITEPDPETQLIGEVFIQAKATIEEVYKIYCYHHDEASALLKSYNQQEEIQQLFRTCVSALKGK---PNLLDMGSLIIKPVQRVMKYPLLLAELWQATPPDHPDHHPLQEALTAAKIINININEFKRRKDIVLKYKRSDYEGSLKGRLNKFNIHTLRKKTERITGYFKILTGVEPQVRDEVFDKEEKM--FRNLEKAVRQLLKNI--------SLLELYAQV--------RYLLSHPLYF---QSRRNGHDPYKQL------GAGLERMLVVPLAALQVMFSAPQKLIQKRYDKLLTCCSCPE-----EASACSEEQLQALRD-YQALNAQLGEELQRFNHAAASILTNCL-----LSTVGL------LRGLMEAARPPVLQLPAPLSNISEVQNSIMEEISN--LSF---VRESSQK--PSMDRKVSFERRERKVPEVPRQSEADRARVLALYPQDRLYQLKRNCNACQEQDVSLLEGELVALLEDRDPLGSSSRWRVDTGGECTQGYVYSSFL--------KVYNPQRDVSEGSEDFDNLSLFVSGSRSCSLYGFTSSGQQG----------APENTQENS-ADAEEHFYAVYAFQARCDKELTLQEYQPVRILQFSDLGGNKEWWLAEA--NGQRGYVPANYLGR 681
BLAST of Rho guanine nucleotide exchange factor 38 vs. Ensembl Cavefish
Match: arhgef37 (Rho guanine nucleotide exchange factor 37 [Source:NCBI gene;Acc:103046351]) HSP 1 Score: 95.9005 bits (237), Expect = 1.146e-19 Identity = 153/593 (25.80%), Postives = 240/593 (40.47%), Query Frame = 3
Query: 1527 QDLKITLEAFDKNLIPTKIPDQDFHLLFGDLKSVIAVAEEFLSKL-SANMEDGLDKI--AVGSVFLQSVSSFEEVYKEYCVNYDRKLDLINKKSKASNVTDFVSDGLNRLNDLGVFASTLDMMLVKPLQRFLKYPLFLKTIIENTLPDHPDINDLIAASSEFDVLAQKINEKKRFEELRQITFDRTEKWHMR------TIHAIQKKPKRVIVSI---SGAV-QNEDTEYQEIVIKFKELKKCISFFIETVFILRDNLKEILNLYSAITDDFTSIIKSNFGSQLHFY-LVACKRGETD---------YFKKYYTVANKTCI-------LDSLVVNPLNKLLELFSGPALLIKKRQSKYIDYLAMKQRCDDKETSRVQIDKLDQLRNQYLAINNTLKHELPILISKSSVIFNECIGNYL-----------QLSTS---TLQSNILSLKNLIEGDQLSTEEEQRN----CRNHQNEILA-FLQRDLLSFNPQYRNSINKGDXXXXXXXXXXXXXXXXXXVYNQTETDVIKLREKFEPENLARVKKDFVPTKPHQIHICAGTLVGILKRCNPQGHSTSWLVEVCPKRTGFVPRSYLT 3158
+ L+I NL + P + +F + V+ V+ FLS L A+M+ + + + FL E YKEY NY+ + I K V + + + V ASTL LV P+QR +YPL L+TI ++T P HP L + L +INE KRF E+ + +TE ++ + H+I KK R+ I +G + + +D E+ +V F L+K I IE L DN++ L +H ++CK E D F K TVA + I L +LV PL+ L EL +GP LI+KRQ K +D+ + +E S + D+ + N Y +N L ELP K+ + +G + QL+TS L + L E + S EE R C++ Q+E+ A +Q ++S E + L +K + + ++ V T+ + + G LV ++ + +G WLV+ R G+VP S LT
Sbjct: 100 KHLQICTVTIRSNLEKIQPPLANLDGMFQHIDEVMEVSGRFLSLLHQAHMKPSDPQYLETLCTSFLTLSRDIETAYKEYLANYN-NITAIENGYKQKEVLWMEMVKVIKSSAPEVNASTLSFFLVMPVQRIARYPLLLQTIQKHTDPQHPAYALLEETAHTAVQLNCRINEYKRFREVAD-KYKKTENLTIKDKINRLSGHSIAKKTARLSQYIKHETGMIPKMKDEEFDSLVGFFFVLEKGI---IE----LHDNMEAYL---------------------IHLQRFLSCKPEEADLDLEGEKTALFSKEITVALRQWIYPAYEARLKTLVFKPLSSLRELMTGPRNLIRKRQDKLLDFEMI------EEKSNLSYDE-QAVANTYKTMNTLLLTELPQFNGKALQLLWTTLGAFSCLQRDLSADMEQLATSFTHQLPHSYLDSSAFWEWAEGSVLEEARKLEALCQSVQDELNAPIVQVSVVS------------------------------------EKRLKLLTDKHSSDKIYQLTGPVVATRDLDLTLNKGELVAVISEMDTRGDRRRWLVDAGGPR-GYVPASKLT 618
BLAST of Rho guanine nucleotide exchange factor 38 vs. Ensembl Cavefish
Match: arhgef3 (Rho guanine nucleotide exchange factor 3 [Source:NCBI gene;Acc:103038887]) HSP 1 Score: 65.855 bits (159), Expect = 1.642e-10 Identity = 62/209 (29.67%), Postives = 101/209 (48.33%), Query Frame = 3
Query: 1440 IKLGSILEKKMQKRSXXXXXXXXXXXXXXQDLKITLEAFDKNLIPTKIPDQ-DFHLLFGDLKSVIAVAEEFLSKL-SANMEDGLDKIAVGSVFLQSVSSFEEVYKEYCVNYDRKLDLINKKSKASNVTDFVSDGLNRLNDLGVFASTLDMM--LVKPLQRFLKYPLFLKTIIENTLPDHPDINDLIAASSEFDVLAQKINEKKRFEELR 2054
+ LG +L K KR + I E+ + E+ I+DLK+ +A+ ++ I + + + +FG L S+I + E+ LS+L A DG VG + + + + Y YC N L++ K + V DF+ L F+ LD+ L P R +KYPL L+ I+++T DHPD L A + + +IN + E R
Sbjct: 109 VGLGQMLSSKEIKRQEAIFELSQGEQDLIEDLKLAKKAYHDPMLKLSIMTELELNQIFGTLDSLIPLHEDLLSRLREARKPDG-STDHVGHILVDWLPCLDS-YNSYCSNQVAAKALLDHKKQDHRVHDFLQRCLE-----SPFSRKLDLWNFLDIPRSRLVKYPLLLREILKHTANDHPDRQHLDEAINMIQSIVAEINTQTGESECR 310
BLAST of Rho guanine nucleotide exchange factor 38 vs. Ensembl Cavefish
Match: arhgef3 (Rho guanine nucleotide exchange factor 3 [Source:NCBI gene;Acc:103038887]) HSP 1 Score: 65.4698 bits (158), Expect = 2.253e-10 Identity = 62/209 (29.67%), Postives = 101/209 (48.33%), Query Frame = 3
Query: 1440 IKLGSILEKKMQKRSXXXXXXXXXXXXXXQDLKITLEAFDKNLIPTKIPDQ-DFHLLFGDLKSVIAVAEEFLSKL-SANMEDGLDKIAVGSVFLQSVSSFEEVYKEYCVNYDRKLDLINKKSKASNVTDFVSDGLNRLNDLGVFASTLDMM--LVKPLQRFLKYPLFLKTIIENTLPDHPDINDLIAASSEFDVLAQKINEKKRFEELR 2054
+ LG +L K KR + I E+ + E+ I+DLK+ +A+ ++ I + + + +FG L S+I + E+ LS+L A DG VG + + + + Y YC N L++ K + V DF+ L F+ LD+ L P R +KYPL L+ I+++T DHPD L A + + +IN + E R
Sbjct: 84 VGLGQMLSSKEIKRQEAIFELSQGEQDLIEDLKLAKKAYHDPMLKLSIMTELELNQIFGTLDSLIPLHEDLLSRLREARKPDG-STDHVGHILVDWLPCLDS-YNSYCSNQVAAKALLDHKKQDHRVHDFLQRCLE-----SPFSRKLDLWNFLDIPRSRLVKYPLLLREILKHTANDHPDRQHLDEAINMIQSIVAEINTQTGESECR 285
BLAST of Rho guanine nucleotide exchange factor 38 vs. Ensembl Sea Lamprey
Match: dnmbp (dynamin binding protein [Source:NCBI gene;Acc:100005174]) HSP 1 Score: 149.443 bits (376), Expect = 1.682e-36 Identity = 144/571 (25.22%), Postives = 254/571 (44.48%), Query Frame = 3
Query: 1530 DLKITLEAFDKNLIPTKIPDQDFHLLFGDLKSVIAVAEEFLSKLSANMEDGLDK-----IAVGSVFLQSVSSFEEVYKEYCVNYDRKLDLINKKSKASNVTDFVSDGLNRLNDLGVFASTLDMMLVKPLQRFLKYPLFLKTIIENTLPDHPDINDLIAASSEFDVLAQKINEKKRFEEL--------RQITFDRTEKWHMRTIHAIQKKPKRV---IVSISG-AVQNEDTEYQEIVIKFKELKKCISFFIETVFILRDNLKEILNLYSAITDDFTSIIKSNFGSQLHFYLVACKRGETDYFKKYYTVANKTCILDSLVVNPLNKLLELFSGPALLIKKRQSKYIDYLAMKQRCDDKETSRVQIDKLDQLRNQYLAINNTLKHELPILISKSSVIFNECIGN----YLQLSTSTLQSNILSLKNLIEGDQLSTEEEQRNCRNHQN-EILAFLQRDLLSF-------NPQYRNSINKGDXXXXXXXXXXXXXXXXXXVYNQTETDVIKLREKFEPENLARVKKDFVPTKPHQIHICAGTLVGILKRCNPQGHSTSWLVEVCPKRTGFVPRSYL 3155
DL+ E L T++ + D LFG+L++V+ V F L + + + ++ G +FL S EEVYK YC N+D + L+ K ++ ++ L + + + + L +L+KP+QR ++YPL L ++ T P HPD L A L INE KR ++L D+ K +M H+I KK RV + ++G A Q D ++E F+ L++ + F+ ++ + L+E L + F+++ + Y C+ T+ F ++ +D LV++PL+ LL F+GP L++KR K +DY A ++ ++ R + ++L + Y+A+N L ELP+L + + N + L + LQ + L N++ ++ ST EQ+ ++ L LQR SF P RN + + + + QT++ +L +F P+ L + + + + + G LV ++K+ +P G W V GFV S+L
Sbjct: 759 DLQFCREEIYIPLRKTQVANLDVEGLFGNLEAVLEVNARFYESLQLSADGRVSYGDDVLLSPGEIFLAFKSELEEVYKVYCRNHDDAISLLEASEKDEDIKAQMAVCLKNMRERSNYIN-LGALLIKPVQRVMRYPLLLTELLGATPPSHPDQPSLSKALVALRQLNHNINEFKRRKDLVVKYRKDDDSSLIDKLSKLNM---HSILKKSSRVSGHLKHLTGMASQIRDEAFEEEERGFRGLERAVKSFLRSLSLYTQQLREALAAELQCSSSFSALHAKPDADR---YQHTCRHIATESFPQFKDR------VDRLVISPLSALLASFAGPHKLVQKRYDKLLDYSARRE-ASERNRDRPESEELQATQKDYVALNAQLLEELPLLRAGGQALLGAAARNLVAVHRDLVLAILQ-QLQPLDNIL--NKKSTAAEQQGAFGARHVHALTELQR--FSFMLSGILVEPGPRNPLATSPDGTRYNVAGVQATSGS----TQTDSGRSQLLARFPPDRLFVLDRKVNVAQDLDLALSEGELVAVIKQQDPMGSHRRWFVSNGEVAQGFVYSSFL 1306
BLAST of Rho guanine nucleotide exchange factor 38 vs. Ensembl Sea Lamprey
Match: ENSPMAT00000008024.1 (pep scaffold:Pmarinus_7.0:GL476484:132482:154761:-1 gene:ENSPMAG00000007248.1 transcript:ENSPMAT00000008024.1 gene_biotype:protein_coding transcript_biotype:protein_coding) HSP 1 Score: 66.6254 bits (161), Expect = 8.172e-12 Identity = 52/165 (31.52%), Postives = 79/165 (47.88%), Query Frame = 3
Query: 1569 IPTKIPDQDFHLLFGDLKSVIAVAEEFLSKLSANMED-GLDKIAVGSVFLQSVSSFEEVYKEYCVNYDRKLDLINKKSKASNVTDFVSDGLNRLND---LGVFASTLDMMLVKPLQRFLKYPLFLKTIIENTLPDHPDINDLIA-ASSEFDVLAQKINEKKRFEE 2048
I ++P+ D + LFG++K + E L +L ED D +A+ F++ FE +Y +YC N+ ++L+ K + + F D L LG F L+KP+QR LKY L L+ IE L D +++ A S +A INE KR E
Sbjct: 41 ISQRLPNDDVNTLFGNIKEIYKFNSELLEEL----EDCSNDPVAIAECFVEKSGGFE-IYTQYCTNFPSSMELLTKCMRTKSTAKFFRDHQAALKHNLPLGSF-------LLKPVQRILKYHLLLQE-IEKRLDKSTDGYEVVQDALSAMHGVAWHINEMKRKHE 192
BLAST of Rho guanine nucleotide exchange factor 38 vs. Ensembl Sea Lamprey
Match: ENSPMAT00000008020.1 (pep scaffold:Pmarinus_7.0:GL476484:132482:154779:-1 gene:ENSPMAG00000007248.1 transcript:ENSPMAT00000008020.1 gene_biotype:protein_coding transcript_biotype:protein_coding) HSP 1 Score: 66.6254 bits (161), Expect = 9.366e-12 Identity = 52/165 (31.52%), Postives = 79/165 (47.88%), Query Frame = 3
Query: 1569 IPTKIPDQDFHLLFGDLKSVIAVAEEFLSKLSANMED-GLDKIAVGSVFLQSVSSFEEVYKEYCVNYDRKLDLINKKSKASNVTDFVSDGLNRLND---LGVFASTLDMMLVKPLQRFLKYPLFLKTIIENTLPDHPDINDLIA-ASSEFDVLAQKINEKKRFEE 2048
I ++P+ D + LFG++K + E L +L ED D +A+ F++ FE +Y +YC N+ ++L+ K + + F D L LG F L+KP+QR LKY L L+ IE L D +++ A S +A INE KR E
Sbjct: 39 ISQRLPNDDVNTLFGNIKEIYKFNSELLEEL----EDCSNDPVAIAECFVEKSGGFE-IYTQYCTNFPSSMELLTKCMRTKSTAKFFRDHQAALKHNLPLGSF-------LLKPVQRILKYHLLLQE-IEKRLDKSTDGYEVVQDALSAMHGVAWHINEMKRKHE 190
BLAST of Rho guanine nucleotide exchange factor 38 vs. Ensembl Sea Lamprey
Match: ENSPMAT00000009021.1 (pep scaffold:Pmarinus_7.0:GL482604:596:7954:-1 gene:ENSPMAG00000008160.1 transcript:ENSPMAT00000009021.1 gene_biotype:protein_coding transcript_biotype:protein_coding) HSP 1 Score: 59.3066 bits (142), Expect = 1.841e-9 Identity = 50/196 (25.51%), Postives = 84/196 (42.86%), Query Frame = 3
Query: 1578 KIPDQDFHLLFGDLKSVIAVAEEFLSKLSANMEDGLDKIAVGSVFLQSVSSFEEVYKEYCVNYDRKLDLINKKSKASNVTDFVSDGLNRLNDLGVFASTLDMM---LVKPLQRFLKYPLFLKTIIENTLPDHPDINDLIAASSEFDVLAQKINEKKRFEELR-QITFDRTEKWHMRTIHAIQKKPKRVIVSISGAV 2153
K+ D L G+L+ V A + + L + + VG F+ ++ +Y YC N+ + + + S+ + +F + GV + L M+ L KP R KYP LK + + HPD ND+ A + F LA + E ++ +EL Q+ + W + A+ IV +S AV
Sbjct: 126 KLSATDVSTLMGNLEDVCAFQQGLMQALEDCTKVPESQQTVGGCFMSLMNQMHGLYLAYCCNHPWAVRTLQEHSEV--LGEF-------MESKGVSSPGLLMLTTSLSKPFMRLDKYPTLLKELERHMEDIHPDRNDIHGAMTAFKTLATQCREMRKRKELELQMMTEPIRGWEGEDMKALGS-----IVYMSQAV 307
BLAST of Rho guanine nucleotide exchange factor 38 vs. Ensembl Sea Lamprey
Match: ARHGEF37 (Rho guanine nucleotide exchange factor 37 [Source:HGNC Symbol;Acc:HGNC:34430]) HSP 1 Score: 60.077 bits (144), Expect = 2.643e-9 Identity = 46/177 (25.99%), Postives = 80/177 (45.20%), Query Frame = 3
Query: 1527 QDLKITLEAFDKNLIPTKIPDQDFHLLFGDLKSVIAVAEEFLSKLSANMEDGLDK---IAV-GSVFLQSVSSFEEVYKEYCVNYDRKLDLINKKSKASNVTDFVSDGLNR--LNDLGVFASTLDMMLVKPLQRFLKYPLFLKTIIENTLPDHPDINDLIAASSEFDVLAQKINEKKR 2039
L++ ++ L T++ D L+FG+++ +I V++ L L G + +AV G VF + E Y+ YC Y+ + K + + T + + LG+ L ML+KP+QR ++Y L L+ ++ T HP+ L A + INE+KR
Sbjct: 48 HHLRLCVDLMLAPLRETQVEGPDVSLVFGNMEEIIGVSQALLQALHDCTRGGSESHSTLAVSGEVFEKFSPDIEAAYRPYCQYYEEAAACL-KCCRGNPATSARIEACEAQLVEQLGMNVD-LSFMLIKPVQRVMRYSLLLQAVLNRTPEGHPEHAALKRAVRALLDVNSSINEQKR 222
BLAST of Rho guanine nucleotide exchange factor 38 vs. Ensembl Yeast
Match: LSB1 (Negative regulator of actin nucleation-promoting factor activity; interacts with Las17p, a homolog of human Wiskott-Aldrich Syndrome protein (WASP), via an N-terminal SH3 domain, and along with PIN3 cooperatively inhibits the nucleation of actin filaments; overexpression blocks receptor-mediated endocytosis; protein increases in abundance and forms nuclear foci in response to DNA replication stress; LSB1 has a paralog, PIN3, that arose from the whole genome duplication [Source:SGD;Acc:S000003368]) HSP 1 Score: 51.2174 bits (121), Expect = 2.454e-7 Identity = 23/54 (42.59%), Postives = 37/54 (68.52%), Query Frame = 3
Query: 108 FYKALFDYESTEIQDLHFKTNDIIEFLSKSSPDWYQGRNIMSGDSGLFPTNFVE 269
+ +AL+D+E+ + DL KT D I+ L K SPDWY+G++ + G+FP N+V+
Sbjct: 57 YVEALYDFEAQQDGDLSLKTGDKIQVLEKISPDWYRGKS--NNKIGIFPANYVK 108
BLAST of Rho guanine nucleotide exchange factor 38 vs. Ensembl Nematostella
Match: EDO44980 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7RUA3]) HSP 1 Score: 110.923 bits (276), Expect = 1.815e-24 Identity = 110/435 (25.29%), Postives = 188/435 (43.22%), Query Frame = 3
Query: 1527 QDLKITLEAFDKNLIPTKIPDQDFHLLFGDLKSVIAVAEEFLSKLSANMEDGLDKIAVGSVFLQSVSSFEEVYKEYCVNYDRKLDLINKKSKASNVTDFVSDGLNRLNDLGVFASTLDMMLVKPLQRFLKYPLFL------------------KTI--------IENTLPDHPDINDLIAASSEFDVLAQKINEKKRFEELRQITFDRTE------KWHMRTIHAIQKKPKRVIVSISGAV----QNEDTEYQEIVIKFKELKKCISFFIETVFILRDNLKEILNLYSAITDDFT-SIIKSNFGSQ--LHFYLVACKRGETDYFKKYYTVANKTCILDSL-------VVNPLNKLLELFSGPALLIKKRQSKYIDYLAMKQRCD---DKETSRVQIDKLDQLRNQYLAINNTLKHELPILISKSSVIFNECIGNY 2684
+DL+ L+ F + L TK+ D + +LFG++ SV+ + L A ++D + +G F + + VY YC N+D + L+ K + L+ + D L L+KP+QR LKYPL L KTI ++ T H D ++L+ A S +A INE KR ++L + + +TE K+ + H++ KK R ++ + Q D + E KF L+K + I+ V S+ + F ++ + Q +YL A E ++ + +LD+ V+ PLN LL +F GP LI+KR K +DY + + + DK+ + ++L+ + Y A+N L ELP+ K+ + +C+ N+
Sbjct: 994 RDLQTCLKYFYEELKNTKVVDAE--VLFGNMHSVVETSTRLLGSFEAALQDDKQQ-ELGKCFAEHAEEIKSVYSTYCKNHDDAIGLLEKYEDCLEAQEAFRKCLDAVRDT-TKCWDLSSFLIKPVQRVLKYPLLLSELLKVIPYKVYGSTAKCKTIRIKYMARLLKCTPQIHKDKDNLVRALSAMTEVAATINEVKRRKDL-VVKYKKTEESGISNKFQKLSWHSVMKKSSRFTQKLTQSTGLVNQTVDKSFNEEEKKFNNLEKTVKNLIKNV--------------SSYVEQFQDTVTRQEVNGQNIQEYYLDASTCTEVTLYQSTQQRISGI-LLDAFMGEVQYCVLTPLNSLLAMFQGPQRLIQKRHHKCLDYDSWSNKMEKIKDKDKLKQAKEELESAKRNYEALNAQLLEELPLFRQKTMSLVKDCVLNF 1408 HSP 2 Score: 49.6766 bits (117), Expect = 8.244e-6 Identity = 32/84 (38.10%), Postives = 50/84 (59.52%), Query Frame = 3
Query: 600 LHGMKGVFSLKNVYSEKI-SSENIDRKNIWITLFDYSGTHVNDLSIRKGDKLKFLDRIDNNWNLMQNENGKVGMTPVTYVKNIS 848
L+ KG+F + Y+EKI +S IDR + I YS ++S++KGD +K L+ I NNW L + NG +G+ P +V++ S
Sbjct: 89 LNSKKGLFPIS--YTEKIDNSYTIDRYVVAIQ--SYSAQRPGEISLKKGDFVKVLEEIGNNW-LRGDINGTIGIFPCVFVEDCS 167
BLAST of Rho guanine nucleotide exchange factor 38 vs. Ensembl Nematostella
Match: EDO27464 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7T967]) HSP 1 Score: 62.3882 bits (150), Expect = 3.761e-10 Identity = 45/152 (29.61%), Postives = 76/152 (50.00%), Query Frame = 3
Query: 1599 HLLFGDLKSVIAVAEEFLSKLSANMEDGLDK-----IAVGSVFLQSVSSFEEVYKEYCVNYDRKLDLINKKSKASNVTDFVSDGLNRLNDLGVFASTLDMMLVKPLQRFLKYPLFLKTIIENTLPDHPDINDLIAASSEFDVLAQKINEKKR 2039
+LLF +++ + EF KL +ED K +G VFL++ F+ +Y EYC N+ + + +++N F + L D+ +LD L+ P+Q+ KYPL L ++++T P H D + + A +A INE+KR
Sbjct: 19 YLLFSNIEQIY----EFHQKLLLQLEDCYLKDNPCDSMIGRVFLENKEGFQ-IYSEYCNNHPHAIAELKTLCESNNYKHFF-EACRLLQDM--INISLDGFLLTPVQKICKYPLQLAELLKHTYPTHKDYDAVHDALRTMKEVASLINERKR 162
BLAST of Rho guanine nucleotide exchange factor 38 vs. Ensembl Nematostella
Match: EDO45201 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7RTF1]) HSP 1 Score: 61.6178 bits (148), Expect = 1.215e-9 Identity = 45/152 (29.61%), Postives = 76/152 (50.00%), Query Frame = 3
Query: 1599 HLLFGDLKSVIAVAEEFLSKLSANMEDGLDK-----IAVGSVFLQSVSSFEEVYKEYCVNYDRKLDLINKKSKASNVTDFVSDGLNRLNDLGVFASTLDMMLVKPLQRFLKYPLFLKTIIENTLPDHPDINDLIAASSEFDVLAQKINEKKR 2039
+LLF +++ + EF KL +ED K +G VFL++ F+ +Y EYC N+ + + +++N F + L D+ +LD L+ P+Q+ KYPL L ++++T P H D + + A +A INE+KR
Sbjct: 135 YLLFSNIEQIY----EFHQKLLLQLEDCYLKDNPCDSMIGRVFLENKEGFQ-IYSEYCNNHPHAIAELKTLCESNNYKHFF-EACRLLQDM--INISLDGFLLTPVQKICKYPLQLAELLKHTYPTHKDYDAVHDALRTMKEVASLINERKR 278
BLAST of Rho guanine nucleotide exchange factor 38 vs. Ensembl Nematostella
Match: EDO38076 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7SE08]) HSP 1 Score: 51.6026 bits (122), Expect = 2.821e-7 Identity = 21/56 (37.50%), Postives = 38/56 (67.86%), Query Frame = 3
Query: 102 MIFYKALFDYESTEIQDLHFKTNDIIEFLSKSSPDWYQGRNIMSGDSGLFPTNFVE 269
M +ALFD+E+ E ++ FK D IE + S +W++G+ + +G+ G+FP+N+V+
Sbjct: 132 MEAVQALFDFEAQEEGEVSFKRGDCIEVIDNSDVNWWRGKVLTTGEIGMFPSNYVK 187
BLAST of Rho guanine nucleotide exchange factor 38 vs. Ensembl Nematostella
Match: EDO29864 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7T2F6]) HSP 1 Score: 49.2914 bits (116), Expect = 4.689e-7 Identity = 21/50 (42.00%), Postives = 33/50 (66.00%), Query Frame = 3
Query: 117 ALFDYESTEIQDLHFKTNDIIEFLSKSSPDWYQGRNIMSGDSGLFPTNFV 266
AL+D+ + E +L+FK + IE L K +W++GR +G+ GLFP N+V
Sbjct: 63 ALYDFVAQEAGELNFKKGNHIEVLDKEDDNWWKGRVAETGEEGLFPRNYV 112
BLAST of Rho guanine nucleotide exchange factor 38 vs. Ensembl Medaka
Match: dnmbp (dynamin binding protein [Source:NCBI gene;Acc:101156363]) HSP 1 Score: 160.999 bits (406), Expect = 2.311e-39 Identity = 157/568 (27.64%), Postives = 263/568 (46.30%), Query Frame = 3
Query: 1527 QDLKITLEAFDKNLIPTKIPDQDFHLLFGDLKSVIAVAEEFLSKLSANMEDGLDKIAVGSVFLQSVSSFEEVYKEYCVNYDRKLDLINKKSKASNVTDFVSDGLNRLNDLGVFASTLDMMLVKPLQRFLKYPLFLKTIIENTLPDHPDINDLIAASSEFDVLAQKINEKKRFEEL-------RQITF-DRTEKWHMRTIHAIQKKPKRV---IVSISG-AVQNEDTEYQEIVIKFKELKKCISFFIETVFILRDNLKEILNLYSAITDDFTSIIKSNFGSQLHFYLVACKRGETDYFKKYYTVANKTCILDSLVVNPLNKLLELFSGPALLIKKRQSKYIDYLAMKQRCDDKETSRVQIDKLDQLRNQYLAINNTLKHELPILISKSSVIFNECIGNYLQLSTSTLQSNILSLKNLIE---------GDQLSTEEEQRNCRNHQNEILAFLQRDLLSFNPQ---YRNSINKG-DXXXXXXXXXXXXXXXXXXVYNQTETDVIKLREKFEPENLARVKKDFVPTKPHQIHICAGTLVGILKRCNPQGHSTSWLVEVCPKRTGFVPRSYL 3155
+DL + +E + L ++ + DF+ LFG++ SVI +++ +L + ++G FL S EEVYK YC N+D + L+ K + V + L RL + + L L+KP+QR ++YPL L ++ T H D L A + INE KR ++L + TF D+ K M H+I KK RV + ++G A Q +D + E KF+ ++ I FI + + +L+E ++ F I + A R +D +K+ +T ++LV+NPL +LL +F+GP LI+KR K +DY K+R + + RVQ ++L RN Y A+N L ELP + + +F C+ + Q +++ + LK L++ G+ ++ +E+ NC +L LQ SF P+ S K + + + QT+ L ++ PENL + +++F + I I G LVG++K+ +P G WL++ + GFV S+L
Sbjct: 860 KDLNMCVEEIIEPLQEKQVKNMDFNGLFGNITSVIELSQRLYDELQ-------ETDSIGKTFLDFRSQMEEVYKLYCQNHDDAISLLESYEKDEGIQRHVLECLERLRGKANYIN-LGSFLIKPVQRVMRYPLLLTELLGATPESHHDRLQLTKAVQVVKEINVNINEYKRRKDLVMKYRKGDEDTFIDKISKLSM---HSIIKKSNRVSSHLKQLTGMAPQFKDEVFDEAEKKFRLQERLIKTFIRDISLYLQHLRESASVKVLAAISFCDIYNERSLMDPECFQRA-HRCISD--RKFTQFKERT---EALVINPLTQLLAMFAGPYKLIQKRFDKLLDYDNCKERAERLKDRRVQ-EELRAARNNYEALNAQLLDELPKFLQTAEEMFLGCVTAFAQAQKDFMRTTMEELKPLLQQFSNKGATSGNLIAQFQEEYNC------VLRLLQS--FSFCPENLPLTTSTKKPVEKKTLDKQTSKKQLQGPPNCSLQTDEHRTALLVRYGPENLFQAERNFNAAQDLDISIQEGDLVGVIKQQDPMGSQNRWLIDNGVTK-GFVYSSFL 1400
BLAST of Rho guanine nucleotide exchange factor 38 vs. Ensembl Medaka
Match: dnmbp (dynamin binding protein [Source:NCBI gene;Acc:101156363]) HSP 1 Score: 157.532 bits (397), Expect = 2.789e-38 Identity = 159/580 (27.41%), Postives = 264/580 (45.52%), Query Frame = 3
Query: 1527 QDLKITLEAFDKNLIPTKIPDQDFHLLFGDLKSVIAVAEEFLSKLSANMEDGLDKIAVGSVFLQSVSSFEEVYKEYCVNYDRKLDLINKKSKASNVTDFVSDGLNRLN------------DLGVFASTLDMMLVKPLQRFLKYPLFLKTIIENTLPDHPDINDLIAASSEFDVLAQKINEKKRFEEL-------RQITF-DRTEKWHMRTIHAIQKKPKRV---IVSISG-AVQNEDTEYQEIVIKFKELKKCISFFIETVFILRDNLKEILNLYSAITDDFTSIIKSNFGSQLHFYLVACKRGETDYFKKYYTVANKTCILDSLVVNPLNKLLELFSGPALLIKKRQSKYIDYLAMKQRCDDKETSRVQIDKLDQLRNQYLAINNTLKHELPILISKSSVIFNECIGNYLQLSTSTLQSNILSLKNLIE---------GDQLSTEEEQRNCRNHQNEILAFLQRDLLSFNPQ---YRNSINKG-DXXXXXXXXXXXXXXXXXXVYNQTETDVIKLREKFEPENLARVKKDFVPTKPHQIHICAGTLVGILKRCNPQGHSTSWLVEVCPKRTGFVPRSYL 3155
+DL + +E + L ++ + DF+ LFG++ SVI +++ +L + ++G FL S EEVYK YC N+D + L+ K + V + L RL +LG F L+KP+QR ++YPL L ++ T H D L A + INE KR ++L + TF D+ K M H+I KK RV + ++G A Q +D + E KF+ ++ I FI + + +L+E ++ F I + A R +D +K+ +T ++LV+NPL +LL +F+GP LI+KR K +DY K+R + + RVQ ++L RN Y A+N L ELP + + +F C+ + Q +++ + LK L++ G+ ++ +E+ NC +L LQ SF P+ S K + + + QT+ L ++ PENL + +++F + I I G LVG++K+ +P G WL++ + GFV S+L
Sbjct: 860 KDLNMCVEEIIEPLQEKQVKNMDFNGLFGNITSVIELSQRLYDELQ-------ETDSIGKTFLDFRSQMEEVYKLYCQNHDDAISLLESYEKDEGIQRHVLECLERLRAIYRNWGKANYINLGSF-------LIKPVQRVMRYPLLLTELLGATPESHHDRLQLTKAVQVVKEINVNINEYKRRKDLVMKYRKGDEDTFIDKISKLSM---HSIIKKSNRVSSHLKQLTGMAPQFKDEVFDEAEKKFRLQERLIKTFIRDISLYLQHLRESASVKVLAAISFCDIYNERSLMDPECFQRA-HRCISD--RKFTQFKERT---EALVINPLTQLLAMFAGPYKLIQKRFDKLLDYDNCKERAERLKDRRVQ-EELRAARNNYEALNAQLLDELPKFLQTAEEMFLGCVTAFAQAQKDFMRTTMEELKPLLQQFSNKGATSGNLIAQFQEEYNC------VLRLLQS--FSFCPENLPLTTSTKKPVEKKTLDKQTSKKQLQGPPNCSLQTDEHRTALLVRYGPENLFQAERNFNAAQDLDISIQEGDLVGVIKQQDPMGSQNRWLIDNGVTK-GFVYSSFL 1406
BLAST of Rho guanine nucleotide exchange factor 38 vs. Ensembl Medaka
Match: arhgef38 (Rho guanine nucleotide exchange factor 38 [Source:NCBI gene;Acc:101171227]) HSP 1 Score: 94.7449 bits (234), Expect = 2.808e-19 Identity = 112/418 (26.79%), Postives = 197/418 (47.13%), Query Frame = 3
Query: 1428 DYESIKLGSILEKKMQKRSXXXXXXXXXXXXXXQDLKITLEAFDKNLIPTKIPDQDFHLLFGDLKSVIAVAEEFLSKLSANMEDG-LDKIAVGSVFLQSVSSFEEVYKEYCVNYDRKLDLINKKSKASNVTD-FVSDGLNRLNDLGVFASTLDM--MLVKPLQRFLKYPLFLKTIIENTLPDHPDINDLIAASSEFDVLAQKINEKKRFEELRQITFDRTE-------KWHMRTIHAIQKKPKR------VIVSISGAVQNEDTEYQEIVIKFKELKKCISFFIETVFILRDNLKEILNLYSAITDDFTSIIKSNFGSQLHFYLVACKRGETDYFKKYYTVANKTCILDSLVVNPLNKLLELFSGPALLIKKRQSKYIDYLAMKQRCDDKETSRVQIDKLDQLRNQYLAINNTLKHEL 2630
D E ++L +KM +R+ +I+E+++TEK ++ DL++ ++ + L ++ D D LF ++++V V+ E L +L M D + + +G VF+Q+ ++ E+VYK YC ++D + K + F++ L L A+ LDM +L+KP+QR +KYPL L + + T DHPD L A + ++ INE +R +++ + + R E K IH+I+KK R ++ + V++E + +E + F+ L K + ++ V + + I+ S L + + E K +A ++ +V+ PL+ L +F+ P LI+KR K +DY C E D D R Y A+NN L EL
Sbjct: 87 DPEEVRL-----RKMNRRANVIKELVQTEKDYLTDLELCIKEVVQPLRKMQVLDVDR--LFTNMETVCEVSAELLQRLHDAMADPDPEAVVIGEVFIQAKAALEDVYKIYCYHHDDANMSLKAYEKDEQIKQHFIACVLA----LKGKANLLDMGSLLIKPVQRIMKYPLLLGELWQATPEDHPDHQPLQEAFTTAKIINININEFRRRKDI-VMKYKRLEDEGTLRGKLTKLNIHSIRKKGDRFAGYLKILTGVEPQVRDEVFDREEKL--FRSLGKAVRQLVKNVHCYMQHTQVIIQ------------------SSLELAKLPHRNSEVMIEK----LALNKDRMEKVVLVPLSALQGMFTAPQKLIQKRYDKLLDY------CSGSE------DPADPARRDYEALNNLLVEEL 456
BLAST of Rho guanine nucleotide exchange factor 38 vs. Ensembl Medaka
Match: arhgef37 (Rho guanine nucleotide exchange factor 37 [Source:NCBI gene;Acc:101168631]) HSP 1 Score: 72.4034 bits (176), Expect = 2.277e-12 Identity = 80/278 (28.78%), Postives = 120/278 (43.17%), Query Frame = 3
Query: 1710 FLQSVSSFEEVYKEYCVNYDRKLDLINK-KSKASNVTDFVSDGLNRLNDLGVFASTLDMMLVKPLQRFLKYPLFLKTIIENTLPDHPDINDLIAASSEFDVLAQKINEKKRFEELRQITFDRTEKWHMR------TIHAIQKKPKRVIVSISGAVQNEDTEYQEIV-IKFKELKKCISFFIETVFILRDNLKEIL-NLYSAITDDFTSIIKSNFGSQLHFYLVACKRGETDYFKKYYTVANKTCILDSLVVNPLNKLLELFSGPALLIKKRQSKYIDY 2516
FL S E YKEY NY L N K K + + V+ + + + V AS+L LV P+QR +YPL L+TI ++T P HP L + L +INE KRF E+ + +TE +R H+I KK R S +++E ++V +F L+ + + L +N++ L NL F F + A E + + + + +L+ PL L +L GP LIKKR K +DY
Sbjct: 207 FLALSSDIEAAYKEYLANYSHVTVLENAYKQKEALWKEIVT--VVKASAPEVNASSLSFFLVMPVQRIARYPLLLQTIQKHTDPSHPACALLDKTAHTSVALNCRINEYKRFREVAD-KYKKTENLTIRDKIVRLNTHSIAKKTAR----FSQHIKHETGMAPKVVDEEFDALEGFFAVLDHGILQLLENVETYLFNL-----QGFLECRTEEFDFDMEGEKSAVSYKEITTALRQWVLPTFEKRMRTLIHKPLCALRDLLVGPRNLIKKRFHKLLDY 472
BLAST of Rho guanine nucleotide exchange factor 38 vs. Ensembl Medaka
Match: arhgef37 (Rho guanine nucleotide exchange factor 37 [Source:NCBI gene;Acc:101168631]) HSP 1 Score: 72.4034 bits (176), Expect = 2.277e-12 Identity = 80/278 (28.78%), Postives = 120/278 (43.17%), Query Frame = 3
Query: 1710 FLQSVSSFEEVYKEYCVNYDRKLDLINK-KSKASNVTDFVSDGLNRLNDLGVFASTLDMMLVKPLQRFLKYPLFLKTIIENTLPDHPDINDLIAASSEFDVLAQKINEKKRFEELRQITFDRTEKWHMR------TIHAIQKKPKRVIVSISGAVQNEDTEYQEIV-IKFKELKKCISFFIETVFILRDNLKEIL-NLYSAITDDFTSIIKSNFGSQLHFYLVACKRGETDYFKKYYTVANKTCILDSLVVNPLNKLLELFSGPALLIKKRQSKYIDY 2516
FL S E YKEY NY L N K K + + V+ + + + V AS+L LV P+QR +YPL L+TI ++T P HP L + L +INE KRF E+ + +TE +R H+I KK R S +++E ++V +F L+ + + L +N++ L NL F F + A E + + + + +L+ PL L +L GP LIKKR K +DY
Sbjct: 207 FLALSSDIEAAYKEYLANYSHVTVLENAYKQKEALWKEIVT--VVKASAPEVNASSLSFFLVMPVQRIARYPLLLQTIQKHTDPSHPACALLDKTAHTSVALNCRINEYKRFREVAD-KYKKTENLTIRDKIVRLNTHSIAKKTAR----FSQHIKHETGMAPKVVDEEFDALEGFFAVLDHGILQLLENVETYLFNL-----QGFLECRTEEFDFDMEGEKSAVSYKEITTALRQWVLPTFEKRMRTLIHKPLCALRDLLVGPRNLIKKRFHKLLDY 472
BLAST of Rho guanine nucleotide exchange factor 38 vs. Planmine SMEST
Match: SMESG000056121.1 (SMESG000056121.1) HSP 1 Score: 1392.1 bits (3602), Expect = 0.000e+0 Identity = 751/756 (99.34%), Postives = 753/756 (99.60%), Query Frame = 3
Query: 102 MIFYKALFDYESTEIQDLHFKTNDIIEFLSKSSPDWYQGRNIMSGDSGLFPTNFVEIIIIPQDINEESIYIIKENNDTFEKGTFLVENHVSDNFLSCYLMTDENKSLLNVPLSTLIKLKISSEFQGYTKCIATCDHNEPADNEIAFLTGDTIWMERKINKDFGEGILHGMKGVFSLKNVYSEKISSENIDRKNIWITLFDYSGTHVNDLSIRKGDKLKFLDRIDNNWNLMQNENGKVGMTPVTYVKNISINSPMRLXXXXXXXXXXXXXXXXXXADNQSDFKIIPNTVLQELRNRIVXXXXXXXXXXXXXXXHNKYSTLISNLEALPTGTLVPSENCYETNSTLRPTDISDIPDENEIPEIVLEQFNKREKRIGNDIEVINDNIKSIENKLTHENSQDDIQTMTCNLAFXXXXXXXXXXXXXAIKDQRKNFLSGNTQDVDENDYESIKLGSILEKKMQKRSXXXXXXXXXXXXXXQDLKITLEAFDKNLIPTKIPDQDFHLLFGDLKSVIAVAEEFLSKLSANMEDGLDKIAVGSVFLQSVSSFEEVYKEYCVNYDRKLDLINKKSKASNVTDFVSDGLNRLNDLGVFASTLDMMLVKPLQRFLKYPLFLKTIIENTLPDHPDINDLIAASSEFDVLAQKINEKKRFEELRQITFDRTEKWHMRTIHAIQKKPKRVIVSISGAVQNEDTEYQEIVIKFKELKKCISFFIETVFILRDNLKEILNLYSAITDDFTSIIKSNFGSQLHFYLVACKRGE 2369
MIFYKALFDYES+EIQDLHFKTNDIIEFLSKSSPDWYQGRNIMSGDSGLFPTNFVEIIIIPQDINEESIYIIKENNDTFEKGTFLVENHVSDNFLSCYLMTDENKSLLNVPLSTLIKLKISSE QGYTKCIATCDHNEPADNEIAFLTGDTIWMERKINKDFGEGILHGMKGVFSLKNVYSEKISSENIDRKNIWITLFDYSGTHVNDLSIRKGDKLKFLDRIDNNWNLMQNENGKVGMTPVTYVKNISINSPMRLSISDTETNDNSDTNETPEADNQSDFKIIPNTVLQELRNRIVNSNENEYENLSYCNSHNKYSTLISNLEALPTGTLVPSENCYETNSTLRPTDISDIPDENEIPEIVLEQFNKREKRIGNDIEVINDNIKSIENKLTHENSQDDIQTMTCNLAFLKEERKTKLKELEAIKDQRKNFLSGNTQDVDENDYESIKLGSILEKKMQKRSKIIEEILETEKKFIQDLKITLEAFDKNLIP KIPDQDFHLLFGDLKSVIAVAEEFLSKLSANMEDGLDKIAVGSVFLQSVSSFEEVYKEYCVNYDRKLDLINKKSKASNVTDFVSDGLNRLNDLGVFASTLDMMLVKPLQRFLKYPLFLKTIIENTLPDHPDINDLIAASSEFDVLAQKINEKKRFEELRQITFDRTEKWHMRTIHAIQKKPKRVIVSISGAVQNEDTEYQEIVIKFKELKKCISFFIETVFILRDNLKEILNLYSAITDDFTSIIKSNFGSQLHFYLVACKR +
Sbjct: 1 MIFYKALFDYESSEIQDLHFKTNDIIEFLSKSSPDWYQGRNIMSGDSGLFPTNFVEIIIIPQDINEESIYIIKENNDTFEKGTFLVENHVSDNFLSCYLMTDENKSLLNVPLSTLIKLKISSESQGYTKCIATCDHNEPADNEIAFLTGDTIWMERKINKDFGEGILHGMKGVFSLKNVYSEKISSENIDRKNIWITLFDYSGTHVNDLSIRKGDKLKFLDRIDNNWNLMQNENGKVGMTPVTYVKNISINSPMRLSISDTETNDNSDTNETPEADNQSDFKIIPNTVLQELRNRIVNSNENEYENLSYCNSHNKYSTLISNLEALPTGTLVPSENCYETNSTLRPTDISDIPDENEIPEIVLEQFNKREKRIGNDIEVINDNIKSIENKLTHENSQDDIQTMTCNLAFLKEERKTKLKELEAIKDQRKNFLSGNTQDVDENDYESIKLGSILEKKMQKRSKIIEEILETEKKFIQDLKITLEAFDKNLIPAKIPDQDFHLLFGDLKSVIAVAEEFLSKLSANMEDGLDKIAVGSVFLQSVSSFEEVYKEYCVNYDRKLDLINKKSKASNVTDFVSDGLNRLNDLGVFASTLDMMLVKPLQRFLKYPLFLKTIIENTLPDHPDINDLIAASSEFDVLAQKINEKKRFEELRQITFDRTEKWHMRTIHAIQKKPKRVIVSISGAVQNEDTEYQEIVIKFKELKKCISFFIETVFILRDNLKEILNLYSAITDDFTSIIKSNFGSQLHFYLVACKRAK 756
BLAST of Rho guanine nucleotide exchange factor 38 vs. Planmine SMEST
Match: SMESG000056121.1 (SMESG000056121.1) HSP 1 Score: 1391.71 bits (3601), Expect = 0.000e+0 Identity = 751/756 (99.34%), Postives = 753/756 (99.60%), Query Frame = 3
Query: 102 MIFYKALFDYESTEIQDLHFKTNDIIEFLSKSSPDWYQGRNIMSGDSGLFPTNFVEIIIIPQDINEESIYIIKENNDTFEKGTFLVENHVSDNFLSCYLMTDENKSLLNVPLSTLIKLKISSEFQGYTKCIATCDHNEPADNEIAFLTGDTIWMERKINKDFGEGILHGMKGVFSLKNVYSEKISSENIDRKNIWITLFDYSGTHVNDLSIRKGDKLKFLDRIDNNWNLMQNENGKVGMTPVTYVKNISINSPMRLXXXXXXXXXXXXXXXXXXADNQSDFKIIPNTVLQELRNRIVXXXXXXXXXXXXXXXHNKYSTLISNLEALPTGTLVPSENCYETNSTLRPTDISDIPDENEIPEIVLEQFNKREKRIGNDIEVINDNIKSIENKLTHENSQDDIQTMTCNLAFXXXXXXXXXXXXXAIKDQRKNFLSGNTQDVDENDYESIKLGSILEKKMQKRSXXXXXXXXXXXXXXQDLKITLEAFDKNLIPTKIPDQDFHLLFGDLKSVIAVAEEFLSKLSANMEDGLDKIAVGSVFLQSVSSFEEVYKEYCVNYDRKLDLINKKSKASNVTDFVSDGLNRLNDLGVFASTLDMMLVKPLQRFLKYPLFLKTIIENTLPDHPDINDLIAASSEFDVLAQKINEKKRFEELRQITFDRTEKWHMRTIHAIQKKPKRVIVSISGAVQNEDTEYQEIVIKFKELKKCISFFIETVFILRDNLKEILNLYSAITDDFTSIIKSNFGSQLHFYLVACKRGE 2369
MIFYKALFDYES+EIQDLHFKTNDIIEFLSKSSPDWYQGRNIMSGDSGLFPTNFVEIIIIPQDINEESIYIIKENNDTFEKGTFLVENHVSDNFLSCYLMTDENKSLLNVPLSTLIKLKISSE QGYTKCIATCDHNEPADNEIAFLTGDTIWMERKINKDFGEGILHGMKGVFSLKNVYSEKISSENIDRKNIWITLFDYSGTHVNDLSIRKGDKLKFLDRIDNNWNLMQNENGKVGMTPVTYVKNISINSPMRLSISDTETNDNSDTNETPEADNQSDFKIIPNTVLQELRNRIVNSNENEYENLSYCNSHNKYSTLISNLEALPTGTLVPSENCYETNSTLRPTDISDIPDENEIPEIVLEQFNKREKRIGNDIEVINDNIKSIENKLTHENSQDDIQTMTCNLAFLKEERKTKLKELEAIKDQRKNFLSGNTQDVDENDYESIKLGSILEKKMQKRSKIIEEILETEKKFIQDLKITLEAFDKNLIP KIPDQDFHLLFGDLKSVIAVAEEFLSKLSANMEDGLDKIAVGSVFLQSVSSFEEVYKEYCVNYDRKLDLINKKSKASNVTDFVSDGLNRLNDLGVFASTLDMMLVKPLQRFLKYPLFLKTIIENTLPDHPDINDLIAASSEFDVLAQKINEKKRFEELRQITFDRTEKWHMRTIHAIQKKPKRVIVSISGAVQNEDTEYQEIVIKFKELKKCISFFIETVFILRDNLKEILNLYSAITDDFTSIIKSNFGSQLHFYLVACKR +
Sbjct: 1 MIFYKALFDYESSEIQDLHFKTNDIIEFLSKSSPDWYQGRNIMSGDSGLFPTNFVEIIIIPQDINEESIYIIKENNDTFEKGTFLVENHVSDNFLSCYLMTDENKSLLNVPLSTLIKLKISSESQGYTKCIATCDHNEPADNEIAFLTGDTIWMERKINKDFGEGILHGMKGVFSLKNVYSEKISSENIDRKNIWITLFDYSGTHVNDLSIRKGDKLKFLDRIDNNWNLMQNENGKVGMTPVTYVKNISINSPMRLSISDTETNDNSDTNETPEADNQSDFKIIPNTVLQELRNRIVNSNENEYENLSYCNSHNKYSTLISNLEALPTGTLVPSENCYETNSTLRPTDISDIPDENEIPEIVLEQFNKREKRIGNDIEVINDNIKSIENKLTHENSQDDIQTMTCNLAFLKEERKTKLKELEAIKDQRKNFLSGNTQDVDENDYESIKLGSILEKKMQKRSKIIEEILETEKKFIQDLKITLEAFDKNLIPAKIPDQDFHLLFGDLKSVIAVAEEFLSKLSANMEDGLDKIAVGSVFLQSVSSFEEVYKEYCVNYDRKLDLINKKSKASNVTDFVSDGLNRLNDLGVFASTLDMMLVKPLQRFLKYPLFLKTIIENTLPDHPDINDLIAASSEFDVLAQKINEKKRFEELRQITFDRTEKWHMRTIHAIQKKPKRVIVSISGAVQNEDTEYQEIVIKFKELKKCISFFIETVFILRDNLKEILNLYSAITDDFTSIIKSNFGSQLHFYLVACKRAK 756
BLAST of Rho guanine nucleotide exchange factor 38 vs. Planmine SMEST
Match: SMESG000056110.1 (SMESG000056110.1) HSP 1 Score: 665.611 bits (1716), Expect = 0.000e+0 Identity = 342/344 (99.42%), Postives = 344/344 (100.00%), Query Frame = 3
Query: 2523 MKQRCDDKETSRVQIDKLDQLRNQYLAINNTLKHELPILISKSSVIFNECIGNYLQLSTSTLQSNILSLKNLIEGDQLSTEEEQRNCRNHQNEILAFLQRDLLSFNPQYRNSINKGDXXXXXXXXXXXXXXXXXXVYNQTETDVIKLREKFEPENLARVKKDFVPTKPHQIHICAGTLVGILKRCNPQGHSTSWLVEVCPKRTGFVPRSYLTLSPFAANKVDLIGSKVISGNATYLNNRHSITADSSFDLMQFSPNNHDDTLRQISMVEISPVKTRPRAFSTANIIRIALFPHQSRGESEISMQKNDQLEILESPDKSNSRNWSLAKNLRTGAQGYVPTNYLSK 3554
MKQRCDDKETSRVQIDKLDQLRNQYLAINNTLKHELPILISKSSVIFNECIGNYLQLSTSTLQSNILSLKNLIEGDQLSTEEEQRNCRNHQNEILAFLQRDLLSFNPQYRNSINKGDFSSCFLNCNNSNANLRNC+Y+QTETDVIKLREKFEPENLARVKKDFVPTKPHQIHICAGTLVGILKRCNPQGHSTSWLVEVCPKRTGFVPRSYLTLSPFAANKVDLIGSKVISGNATYLNNRHSITADSSFDLMQFSPNNHDDTLRQISMVEISPVKTRPRAFSTANIIRIALFPHQSRGESEISMQKNDQLEILESPDKSNSRNWSLAKNLRTGAQGYVPTNYLSK
Sbjct: 1 MKQRCDDKETSRVQIDKLDQLRNQYLAINNTLKHELPILISKSSVIFNECIGNYLQLSTSTLQSNILSLKNLIEGDQLSTEEEQRNCRNHQNEILAFLQRDLLSFNPQYRNSINKGDFSSCFLNCNNSNANLRNCIYHQTETDVIKLREKFEPENLARVKKDFVPTKPHQIHICAGTLVGILKRCNPQGHSTSWLVEVCPKRTGFVPRSYLTLSPFAANKVDLIGSKVISGNATYLNNRHSITADSSFDLMQFSPNNHDDTLRQISMVEISPVKTRPRAFSTANIIRIALFPHQSRGESEISMQKNDQLEILESPDKSNSRNWSLAKNLRTGAQGYVPTNYLSK 344
BLAST of Rho guanine nucleotide exchange factor 38 vs. Planmine SMEST
Match: SMESG000065955.1 (SMESG000065955.1) HSP 1 Score: 52.7582 bits (125), Expect = 6.957e-8 Identity = 20/63 (31.75%), Postives = 38/63 (60.32%), Query Frame = 3
Query: 120 LFDYESTEIQDLHFKTNDIIEFLSKSSPDWYQGRNIMSGDSGLFPTNFVEIIIIPQDINEESI 308
+++Y + + +L F N I+ + K+ P+W+ GRN++S GLFP N+V + +EE++
Sbjct: 47 MYNYSAQNVDELSFDKNAILVLIDKNEPEWWMGRNLLSSQEGLFPVNYVRRLQAGNASDEEAM 109
BLAST of Rho guanine nucleotide exchange factor 38 vs. Planmine SMEST
Match: SMESG000017234.1 (SMESG000017234.1) HSP 1 Score: 53.9138 bits (128), Expect = 9.484e-7 Identity = 48/167 (28.74%), Postives = 81/167 (48.50%), Query Frame = 3
Query: 1587 DQDFHLLFGDLKSVIAVAEEFLSKLS-ANMEDGLDKIAVGSVFLQSVSSFEEVYKEYCVNYDRKLDLINK-KSKASNVTDFVSDGLNRLNDLGVFASTLDMMLVKPLQRFLKYPLFLKTIIENT-LPDHPDIN----DLIAASSEFDVLAQKINEKK--RFEELRQI 2060
D++ L+F + +++ FL KL N + + FL+ + FE +Y EYC NY + + +++ ++ AS+ + +L L L+KP+QR LKY L LK +I+ L H N L+ A +A +INEK+ R E+LR++
Sbjct: 161 DKEVELIFSNWRNLRIFHSLFLEKLKLINSYEFSSLQRLSECFLEEIGHFEALYSEYCTNYTQSVKHLHRMETTASHAWQSLIQCQTQLG----HQLPLSTFLLKPVQRILKYHLILKELIQCCKLMSHVSANGVVESLLKALDNMLQVANRINEKQMEREEQLRRL 323 The following BLAST results are available for this feature:
BLAST of Rho guanine nucleotide exchange factor 38 vs. Ensembl Human
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Human e!99) Total hits: 5
BLAST of Rho guanine nucleotide exchange factor 38 vs. Ensembl Celegans
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99) Total hits: 5
BLAST of Rho guanine nucleotide exchange factor 38 vs. Ensembl Fly
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99) Total hits: 5
BLAST of Rho guanine nucleotide exchange factor 38 vs. Ensembl Zebrafish
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99) Total hits: 5
BLAST of Rho guanine nucleotide exchange factor 38 vs. Ensembl Xenopus
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99) Total hits: 5
BLAST of Rho guanine nucleotide exchange factor 38 vs. Ensembl Mouse
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99) Total hits: 5
BLAST of Rho guanine nucleotide exchange factor 38 vs. UniProt/SwissProt
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt) Total hits: 5
BLAST of Rho guanine nucleotide exchange factor 38 vs. TrEMBL
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL) Total hits: 5
BLAST of Rho guanine nucleotide exchange factor 38 vs. Ensembl Cavefish
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99) Total hits: 5
BLAST of Rho guanine nucleotide exchange factor 38 vs. Ensembl Sea Lamprey
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99) Total hits: 5
BLAST of Rho guanine nucleotide exchange factor 38 vs. Ensembl Yeast
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46) Total hits: 1
BLAST of Rho guanine nucleotide exchange factor 38 vs. Ensembl Nematostella
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46) Total hits: 5
BLAST of Rho guanine nucleotide exchange factor 38 vs. Ensembl Medaka
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99) Total hits: 5
BLAST of Rho guanine nucleotide exchange factor 38 vs. Planmine SMEST
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST) Total hits: 5
Analyses
This transcript is derived from or has results from the following analyses Sequences
The following sequences are available for this feature:
transcript sequence >SMED30012806 ID=SMED30012806|Name=Rho guanine nucleotide exchange factor 38|organism=Schmidtea mediterranea sexual|type=transcript|length=3653bpback to top protein sequence of SMED30012806-orf-1 >SMED30012806-orf-1 ID=SMED30012806-orf-1|Name=SMED30012806-orf-1|organism=Schmidtea mediterranea sexual|type=polypeptide|length=1152bp MIFYKALFDYESTEIQDLHFKTNDIIEFLSKSSPDWYQGRNIMSGDSGLFback to top Annotated Terms
The following terms have been associated with this transcript:
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