Expressed conserved protein
Overview
Neoblast Clusters
Zeng et. al., 2018▻ Overview▻ Neoblast Population▻ Sub-lethal Irradiated Surviving X1 and X2 Cell Population
Overview
Single cell RNA-seq of pluripotent neoblasts and its early progeniesWe isolated X1 neoblasts cells enriched in high piwi-1 expression (Neoblast Population), and profiled ∼7,614 individual cells via scRNA-seq. Unsupervised analyses uncovered 12 distinct classes from 7,088 high-quality cells. We designated these classes Nb1 to Nb12 and ordered them based on high (Nb1) to low (Nb12) piwi-1 expression levels. We further defined groups of genes that best classified the cells parsed into 12 distinct cell clusters to generate a scaled expression heat map of discriminative gene sets for each cluster. Expression of each cluster’s gene signatures was validated using multiplex fluorescence in situ hybridization (FISH) co-stained with piwi-1 and largely confirmed the cell clusters revealed by scRNA-seq.We also tested sub-lethal irradiation exposure. To profile rare pluripotent stem cells (PSCs) and avoid interference from immediate progenitor cells, we determined a time point after sub-lethal irradiation (7 DPI) with minimal piwi-1+ cells, followed by isolation and single-cell RNA-seq of 1,200 individual cells derived from X1 (Piwi-1 high) and X2 (Piwi-1 low) cell populations (Sub-lethal Irradiated Surviving X1 and X2 Cell Population)Explore this single cell expression dataset with our NB Cluster Shiny App
Neoblast Population
Sub-lethal Irradiated Surviving X1 and X2 Cell Population
Embryonic Expression
Davies et. al., 2017
Hover the mouse over a column in the graph to view average RPKM values per sample. Embryonic Stages: Y: yolk. S2-S8: Stages 2-8. C4: asexual adult. SX: virgin, sexually mature adult. back to top Anatomical Expression
PAGE et. al., 2020SMED30012789 has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGEPAGE Curations: 12
Homology
BLAST of Expressed conserved protein vs. TrEMBL
Match: A0A158RA24 (Uncharacterized protein OS=Taenia asiatica OX=60517 GN=TASK_LOCUS8271 PE=4 SV=1) HSP 1 Score: 206.068 bits (523), Expect = 1.356e-56 Identity = 107/225 (47.56%), Postives = 161/225 (71.56%), Query Frame = 1 Query: 148 SARFRSPGIVRRNISGDNGFQSAQVAXXXXXXXXXETSNRDVSSNNLSGKRRLSKQDEGTVEQHLEALNNRWRLMAKNQEKMTKEEIMNNYKLLLTDHIKLEKFMSLISRENELTRTRLESDLLDSMMLVEDLKQSLQSRQLNRRSKNDPRESEERRELIKQNKKLLNELHESAKKIEKFELTIFDLQEQVELMDFQMMEVQNQKTIIEEQLEIKGETKAKSSQT 822 +RFRSP + R+ + G + A + +S T N S+ R++ + + E + LN RW ++AKNQE M+K+E++NNY+LL+ DH++LE+F+S+++++NE+ R RLE+DLLD+MM +EDLKQ+L+ R + RR K DPRE+EERR LI+QNKKLLN+L+ESAKKIE ELT +++EQ+EL+DFQM+E++NQK I+EE+L + T+ S+QT Sbjct: 2 GSRFRSPVVPRKVV----GTEEAATTFAKKSKRSKSTENSLEKSDPFM---RMAAKGKAEPEDPMSVLNKRWSIIAKNQETMSKQELLNNYRLLMNDHLRLERFLSIVTKDNEMARNRLETDLLDAMMCIEDLKQALEVR-MARRRKIDPREAEERRSLIRQNKKLLNQLYESAKKIEMLELTKLEMKEQLELLDFQMVEIENQKAIVEEELRRQPVTENGSTQT 218
BLAST of Expressed conserved protein vs. TrEMBL
Match: A0A068Y6A5 (Expressed conserved protein OS=Echinococcus multilocularis OX=6211 GN=EmuJ_000758300 PE=4 SV=1) HSP 1 Score: 206.453 bits (524), Expect = 1.011e-51 Identity = 123/314 (39.17%), Postives = 194/314 (61.78%), Query Frame = 1 Query: 151 ARFRSPGIVRRNISGDNGFQSAQVAXXXXXXXXXETSNRDVSSNNLSGK----RRLSKQDEGTVEQHLEALNNRWRLMAKNQEKMTKEEIMNNYKLLLTDHIKLEKFMSLISRENELTRTRLESDLLDSMMLVEDLKQSLQSRQLNRRSKNDPRESEERRELIKQNKKLLNELHESAKKIEKFELTIFDLQEQVELMDFQMMEVQNQKTIIEEQLEIKGETKAKSSQTSENCAEQELEKWLEEYKHLKVELESVTMDYNQLILEMKSMQTDNEVLKISEENLQEDLVVKINEIKLLKKDIEVLEDRVKNSLDEA 1080 +RFRSP + R+ + + S ++ S R S+ N K R++ + + E + LN RW ++AKNQE M+K+E++NNY+LL+ DH++LE+F+S+I+++NE+ R RLE+DLLD+MM +EDLKQ+L+ R + RR K DPRE+EERR LI+QNKKLLN+L+ESAKKIE ELT +++EQ+EL+DFQM+E++NQK ++EE+L + T+ S+QT ++ L+ +VE SV + E+ + Q + L +L+ N ++ L++D L +++ DEA Sbjct: 3 SRFRSPVVPRKVVGAEEAATS-----------LAKKSKRSKSTENSLEKGDPFMRMAAKSKTDPEDPMSVLNKRWSVVAKNQETMSKQELLNNYRLLMNDHLRLERFLSIITKDNEMARNRLETDLLDAMMCIEDLKQALEVR-MARRRKIDPREAEERRSLIRQNKKLLNQLYESAKKIEMLELTKLEMKEQLELLDFQMVEIENQKAMVEEELRRQPVTENGSTQTDDD-----LDNGPAALAAARVETASV-------LTELANQQAECAALNAKHRHLE-------NLVRELRRDNTDLREQIARVSDEA 285 HSP 2 Score: 64.6994 bits (156), Expect = 1.052e-6 Identity = 56/195 (28.72%), Postives = 96/195 (49.23%), Query Frame = 1 Query: 1729 SAEYYSRKLEEIQLDHTEDQMNALLSDAERAKEETVRHCARLEEELD---ASNRYVXXXXXXXXXXXXXXXXXRRRIETLEQRLM----NGNLNS-----NASISKSIT---------ELETKIAQLETVNSSLMEVNALEKRRMEEQRIRLKDYEQINKSLNEKLNNIQTKELFSQKKINRLQAVYEDLLREYA 2250 S EYYS + ++Q + M L+ E+ + + R A L L A+NR + RR L +RL+ G+ NS +S+ S T + +TK+ +LE VNS+L E + L++ R++EQ R+ E ++L++++ ++Q E +Q+ RLQA+YED+LRE++ Sbjct: 418 SPEYYSAQFSQLQSSSEVEGMRGQLAVCEKRRADLERRVAELSSGLSQAQAANR----------ANEAALTASRRNEAALRRRLLATVDTGSTNSQRSRPTSSLDYSGTPQSGLKDDLDAQTKMIKLEAVNSALSEASQLDRVRLQEQATRIAQLEAEQRTLHDRMASLQASESCAQRASVRLQALYEDMLREFS 602
BLAST of Expressed conserved protein vs. TrEMBL
Match: A0A068WBZ8 (Expressed conserved protein OS=Echinococcus granulosus OX=6210 GN=EgrG_000758300 PE=4 SV=1) HSP 1 Score: 206.453 bits (524), Expect = 1.089e-51 Identity = 119/299 (39.80%), Postives = 190/299 (63.55%), Query Frame = 1 Query: 151 ARFRSPGIVRRNISGDNGFQSAQVAXXXXXXXXXETSNRDVSSNNLSGK----RRLSKQDEGTVEQHLEALNNRWRLMAKNQEKMTKEEIMNNYKLLLTDHIKLEKFMSLISRENELTRTRLESDLLDSMMLVEDLKQSLQSRQLNRRSKNDPRESEERRELIKQNKKLLNELHESAKKIEKFELTIFDLQEQVELMDFQMMEVQNQKTIIEEQLEIKGETKAKSSQTSEN---------CAEQELEKWLEEYKHLKVELESVTMDYNQLILEMKSMQTDN-----EVLKISEENLQED 993 +RFRSP + R+ + + S ++ S R S+ N K R++ + + E + LN RW ++AKNQE M+K+E++NNY+LL+ DH++LE+F+S+I+++NE+ R RLE+DLLD+MM +EDLKQ+L+ R + RR K DPRE+EERR LI+QNKKLLN+L+ESAKKIE ELT +++EQ+EL+DFQM+E++NQK ++EE+L + T+ S+QT ++ A E L E + + E +++ + L ++ ++ DN ++ ++S+E ED Sbjct: 3 SRFRSPVVPRKVVGAEEAATS-----------LAKKSKRSKSTENSLEKGDPFMRMAAKGKTDPEDPMSVLNKRWSVVAKNQETMSKQELLNNYRLLMNDHLRLERFLSIITKDNEMARNRLETDLLDAMMCIEDLKQALEVR-MARRRKIDPREAEERRSLIRQNKKLLNQLYESAKKIEVLELTKLEMKEQLELLDFQMVEIENQKAMVEEELRRQPVTENGSTQTDDDLDNGPAALAAARVETASVLTELANQQAECAALSAKHRHLENLVRELRRDNTDLREQIGRVSDEAEDED 289
BLAST of Expressed conserved protein vs. TrEMBL
Match: A0A0X3NUY6 (Uncharacterized protein OS=Schistocephalus solidus OX=70667 GN=TR142680 PE=4 SV=1) HSP 1 Score: 207.994 bits (528), Expect = 1.129e-51 Identity = 114/210 (54.29%), Postives = 164/210 (78.10%), Query Frame = 1 Query: 154 RFRSPGIVRRNISGDNGFQSAQVAXXXXXXXXXETSNRDVSSNNLSGKRRLSKQDEGTVEQHLEALNNRWRLMAKNQEKMTKEEIMNNYKLLLTDHIKLEKFMSLISRENELTRTRLESDLLDSMMLVEDLKQSLQSRQLNRRSKNDPRESEERRELIKQNKKLLNELHESAKKIEKFELTIFDLQEQVELMDFQMMEVQNQKTIIEEQL 783 RFRSP + R+ + + +A +AKKS+RSKSSET+ R + + L RL K+D+ + + LN RW ++AK QE M+K+EI+NNY+LL+ DH++LE+F+S+++++NE+ R RLESDLLD+MM +EDLKQ+L+ R + RR K DPRE+EERR LI+QNKKLLN+L+ESAKKIE ELT +++EQ+EL+DFQ+ME++NQK IIEE++ Sbjct: 4 RFRSPVVPRKTVCVEE--TAATLAKKSKRSKSSETTPR-IQDSVL----RLEKRDKEAMNDPIADLNKRWSIIAKTQESMSKQEILNNYRLLMNDHLRLERFLSIVTKDNEMARNRLESDLLDAMMCIEDLKQALEIR-MARRRKVDPREAEERRALIRQNKKLLNQLYESAKKIEHLELTKLEMKEQLELLDFQLMEIENQKAIIEEEV 205
BLAST of Expressed conserved protein vs. TrEMBL
Match: A0A094ZGU3 (Uncharacterized protein OS=Schistosoma haematobium OX=6185 GN=MS3_01243 PE=4 SV=1) HSP 1 Score: 188.734 bits (478), Expect = 3.520e-47 Identity = 111/243 (45.68%), Postives = 168/243 (69.14%), Query Frame = 1 Query: 145 NSARFRSPGIVRRNISGDNGFQSAQVAXXXXXXXXXETSNRDVSSNNLSGKRRLSKQDEGTVEQHL--EALNNRWRLMAKNQEKMTKEEIMNNYKLLLTDHIKLEKFMSLISRENELTRTRLESDLLDSMMLVEDLKQSLQSRQLNRRSKNDPRESEERRELIKQNKKLLNELHESAKKIEKFELTIFDLQEQVELMDFQMMEVQNQKTIIEEQLEIKGETKAKSSQTSENCAEQELEKWLEE 867 N RFRSP I RR + G+ A A ++S+ ++++ N+ + +E V++ L E+++ RW L+AKN E M+K+EIMNNY+LL+++ ++LE+F+S++++ NE+ R RLESDLLD+MM +EDLKQ+L+ R L R DPRE+EERR LI+QNKKLLN+L ESAKKIE+ E+T +++EQ+EL+DFQ++EV+NQK +IEE+L T + +QT E+ +L L+E Sbjct: 5 NQERFRSPDISRRPLGGE-----ALAAYTVKKSRRAKSTEPTALDTNVPLVK--CSNEEEKVKEVLNDESMDKRWSLIAKNYENMSKQEIMNNYRLLMSEKLRLERFLSIMTKNNEMARNRLESDLLDAMMCIEDLKQALEIR-LAR----DPREAEERRYLIRQNKKLLNQLFESAKKIERLEVTKVEMKEQLELLDFQIVEVENQKAMIEEELRKIPPTLHEGTQTEESSDSHQLICQLKE 235
BLAST of Expressed conserved protein vs. Ensembl Sea Lamprey
Match: jakmip2 (janus kinase and microtubule interacting protein 2 [Source:ZFIN;Acc:ZDB-GENE-091204-293]) HSP 1 Score: 56.225 bits (134), Expect = 2.673e-8 Identity = 40/132 (30.30%), Postives = 74/132 (56.06%), Query Frame = 1 Query: 385 EKMTKEEIMNNYKLLLTDHIKLEKFMSLI---------SRENELTRTRLESDLLDSMMLVEDLKQSLQSRQLNRRSKNDPRESEERRELIKQNKKLLNELHESAKKIEKFELTIFDLQEQVELMDFQMMEVQ 753 E M +EE ++ L+ ++ L++ SL+ + + LTR +L++DLL VEDL+++L R D EE+++L ++N++LL +LHE + + DLQ+Q ELM+F+++E++ Sbjct: 402 EHMAREETELRFRHLMHEYQALQRAYSLLHEQLGGGLDAERDALTREQLQADLLKYQARVEDLERALSQR------GQDATWVEEKQQLCRRNQELLQKLHELENDENSLKQEVQDLQDQNELMEFRILELE 527
BLAST of Expressed conserved protein vs. Planmine SMEST
Match: SMESG000033788.1 (SMESG000033788.1) HSP 1 Score: 1157.9 bits (2994), Expect = 0.000e+0 Identity = 583/598 (97.49%), Postives = 583/598 (97.49%), Query Frame = 1 Query: 94 MTSPKPSRYLLTSPPVSNSARFRSPGIVRRNISGDNGFQSAQVAXXXXXXXXXETSNRDVSSNNLSGKRRLSKQDEGTVEQHLEALNNRWRLMAKNQEKMTKEEIMNNYKLLLTDHIKLEKFMSLISRENELTRTRLESDLLDSMMLVEDLKQSLQSRQLNRRSKNDPRESEERRELIKQNKKLLNELHESAKKIEKFELTIFDLQEQVELMDFQMMEVQNQKTIIEEQLEIKGETKAKSSQTSENCAEQELEKWLEEYKHLKVELESVTMDYNQLILEMKSMQTDNEVLKISEENLQEDLVVKINEIKLLKKDIEVLEDRVKNSLDEAPVSVGDHAYVRCPTSRDDDTIISNSEDFDDLSVATDSGFEITDNGTKKSNTFNGHIKLVDKDVGLLGDTVKMLLSMLKEKEDETLKSKTDALDTPTFYKSIYDEEDPNFGSIYSKSFNLGLSKISDFDRSGELSGRHSPIGACCSSSYKLQMLEKENRRWKNFVEHIGKSENELLQVIADLEENMRSNKIEIESLREQVLIKGSPQKSTNLINNERSAEYYSRKLEEIQLDHTEDQMNALLSDAERAKEETVRHCARLEEELDASNRYV 1887 MTSPKPSRYLLTSPPVSNSARFRSPGIVRRNISGDNGFQSAQVAKKSRRSKSSETSNRDVSSNNLSGKRRLSKQDEGTVEQHLEALNNRWRLMAKNQEKMTKEEIMNNYKLLLTDHIKLEKFMSLISRENELTRTRLESDLLDSMMLVEDLKQSLQSRQLNRRSKNDPRESEERRELIKQNKKLLNELHESAKKIEKFELTIFDLQEQVELMDFQMME QNQKTIIEEQLEIKGETKAKSSQTSENCAEQELEKWLEEYKHLKVELESVTMDYNQLILEMKSMQTDNEVLKISEENLQEDLVVKINEIKLLKKDIEVLEDRVKNSLDEAPVSVGDHAYVRCPTSRDDDTIISNSEDFDDLSVATDSGFEITDN VDKDVGLLGDTVKMLLSMLKEKEDETLKSKTDALDTPTFYKSIYDEEDPNFGSIYSKSFNLGLSKISDFDRSGELSGRHSPIGACCSSSYKLQMLEKENRRWKNFVEHIGKSENELLQVIADLEENMRSNKIEIESLREQVLIKGSPQKSTNLINNERSAEYYSRKLEEIQLDHTEDQMNALLSDAERAKEETVRHCARLEEELDASNRYV Sbjct: 1 MTSPKPSRYLLTSPPVSNSARFRSPGIVRRNISGDNGFQSAQVAKKSRRSKSSETSNRDVSSNNLSGKRRLSKQDEGTVEQHLEALNNRWRLMAKNQEKMTKEEIMNNYKLLLTDHIKLEKFMSLISRENELTRTRLESDLLDSMMLVEDLKQSLQSRQLNRRSKNDPRESEERRELIKQNKKLLNELHESAKKIEKFELTIFDLQEQVELMDFQMMEAQNQKTIIEEQLEIKGETKAKSSQTSENCAEQELEKWLEEYKHLKVELESVTMDYNQLILEMKSMQTDNEVLKISEENLQEDLVVKINEIKLLKKDIEVLEDRVKNSLDEAPVSVGDHAYVRCPTSRDDDTIISNSEDFDDLSVATDSGFEITDN--------------VDKDVGLLGDTVKMLLSMLKEKEDETLKSKTDALDTPTFYKSIYDEEDPNFGSIYSKSFNLGLSKISDFDRSGELSGRHSPIGACCSSSYKLQMLEKENRRWKNFVEHIGKSENELLQVIADLEENMRSNKIEIESLREQVLIKGSPQKSTNLINNERSAEYYSRKLEEIQLDHTEDQMNALLSDAERAKEETVRHCARLEEELDASNRYV 584
BLAST of Expressed conserved protein vs. Planmine SMEST
Match: SMESG000033789.1 (SMESG000033789.1) HSP 1 Score: 277.715 bits (709), Expect = 4.856e-88 Identity = 156/156 (100.00%), Postives = 156/156 (100.00%), Query Frame = 1 Query: 2068 MEVNALEKRRMEEQRIRLKDYEQINKSLNEKLNNIQTKELFSQKKINRLQAVYEDLLREYAAAKLPIPDKSKIGNSFSQQRCSISEENLRLRQQLNEMKAKYDELKSLLVRYQMCMFSDSKHXXXXXXXXXXXXXXXXXHLRDFELKMNELTKRTT 2535 MEVNALEKRRMEEQRIRLKDYEQINKSLNEKLNNIQTKELFSQKKINRLQAVYEDLLREYAAAKLPIPDKSKIGNSFSQQRCSISEENLRLRQQLNEMKAKYDELKSLLVRYQMCMFSDSKHSASNKMSNSLNKKSFNSHLRDFELKMNELTKRTT Sbjct: 1 MEVNALEKRRMEEQRIRLKDYEQINKSLNEKLNNIQTKELFSQKKINRLQAVYEDLLREYAAAKLPIPDKSKIGNSFSQQRCSISEENLRLRQQLNEMKAKYDELKSLLVRYQMCMFSDSKHSASNKMSNSLNKKSFNSHLRDFELKMNELTKRTT 156 The following BLAST results are available for this feature:
BLAST of Expressed conserved protein vs. Ensembl Human
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Human e!99) Total hits: 0
BLAST of Expressed conserved protein vs. Ensembl Celegans
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99) Total hits: 0
BLAST of Expressed conserved protein vs. Ensembl Fly
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99) Total hits: 0
BLAST of Expressed conserved protein vs. Ensembl Zebrafish
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99) Total hits: 0
BLAST of Expressed conserved protein vs. Ensembl Xenopus
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99) Total hits: 0
BLAST of Expressed conserved protein vs. Ensembl Mouse
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99) Total hits: 0
BLAST of Expressed conserved protein vs. UniProt/SwissProt
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt) Total hits: 0
BLAST of Expressed conserved protein vs. TrEMBL
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL) Total hits: 5
BLAST of Expressed conserved protein vs. Ensembl Cavefish
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99) Total hits: 0
BLAST of Expressed conserved protein vs. Ensembl Sea Lamprey
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99) Total hits: 1
BLAST of Expressed conserved protein vs. Ensembl Yeast
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46) Total hits: 0
BLAST of Expressed conserved protein vs. Ensembl Nematostella
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46) Total hits: 0
BLAST of Expressed conserved protein vs. Ensembl Medaka
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99) Total hits: 0
BLAST of Expressed conserved protein vs. Planmine SMEST
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST) Total hits: 2
Analyses
This transcript is derived from or has results from the following analyses Sequences
The following sequences are available for this feature:
transcript sequence >SMED30012789 ID=SMED30012789|Name=Expressed conserved protein|organism=Schmidtea mediterranea sexual|type=transcript|length=2782bpback to top protein sequence of SMED30012789-orf-1 >SMED30012789-orf-1 ID=SMED30012789-orf-1|Name=SMED30012789-orf-1|organism=Schmidtea mediterranea sexual|type=polypeptide|length=815bp MTSPKPSRYLLTSPPVSNSARFRSPGIVRRNISGDNGFQSAQVAKKSRRSback to top Annotated Terms
The following terms have been associated with this transcript:
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