F-box only protein 42

Overview
NameF-box only protein 42
Smed IDSMED30012729
Length (bp)1865
Neoblast Clusters

Zeng et. al., 2018




▻ Overview

▻ Neoblast Population

▻ Sub-lethal Irradiated Surviving X1 and X2 Cell Population

 



 

Overview

 

Single cell RNA-seq of pluripotent neoblasts and its early progenies


We isolated X1 neoblasts cells enriched in high piwi-1 expression (Neoblast Population), and profiled ∼7,614 individual cells via scRNA-seq. Unsupervised analyses uncovered 12 distinct classes from 7,088 high-quality cells. We designated these classes Nb1 to Nb12 and ordered them based on high (Nb1) to low (Nb12) piwi-1 expression levels. We further defined groups of genes that best classified the cells parsed into 12 distinct cell clusters to generate a scaled expression heat map of discriminative gene sets for each cluster. Expression of each cluster’s gene signatures was validated using multiplex fluorescence in situ hybridization (FISH) co-stained with piwi-1 and largely confirmed the cell clusters revealed by scRNA-seq.

We also tested sub-lethal irradiation exposure. To profile rare pluripotent stem cells (PSCs) and avoid interference from immediate progenitor cells, we determined a time point after sub-lethal irradiation (7 DPI) with minimal piwi-1+ cells, followed by isolation and single-cell RNA-seq of 1,200 individual cells derived from X1 (Piwi-1 high) and X2 (Piwi-1 low) cell populations (Sub-lethal Irradiated Surviving X1 and X2 Cell Population)




Explore this single cell expression dataset with our NB Cluster Shiny App




 

Neoblast Population

 

t-SNE plot shows two-dimensional representation of global gene expression relationships among all neoblasts (n = 7,088 after filter). Cluster identity was assigned based on the top 10 marker genes of each cluster (Table S2), followed by inspection of RNA in situ hybridization patterns. Neoblast groups, Nb.


Expression of F-box only protein 42 (SMED30012729) t-SNE clustered cells

Violin plots show distribution of expression levels for F-box only protein 42 (SMED30012729) in cells (dots) of each of the 12 neoblast clusters.

 

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Sub-lethal Irradiated Surviving X1 and X2 Cell Population

 

t-SNE plot of surviving X1 and X2 cells (n = 1,039 after QC filter) after sub-lethal irradiation. Colors indicate unbiased cell classification via graph-based clustering. SL, sub-lethal irradiated cell groups.

Expression of F-box only protein 42 (SMED30012729) in the t-SNE clustered sub-lethally irradiated X1 and X2 cells.

Violin plots show distribution of expression levels for F-box only protein 42 (SMED30012729) in cells (dots) of each of the 10 clusters of sub-leathally irradiated X1 and X2 cells.

 

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Embryonic Expression

Davies et. al., 2017




Hover the mouse over a column in the graph to view average RPKM values per sample.
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Embryonic Stages: Y: yolk. S2-S8: Stages 2-8. C4: asexual adult. SX: virgin, sexually mature adult.
For further information about sample preparation and analysis for the single animal RNA-Seq experiment, please refer to the Materials and Methods

 

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Anatomical Expression

PAGE et. al., 2020




SMED30012729

has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGE



PAGE Curations: 1

  
Expressed InReference TranscriptGene ModelsPublished TranscriptTranscriptomePublicationSpecimenLifecycleEvidence
parenchymaSMED30012729h1SMcG0005268 dd_Smed_v4_9025_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018
FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
Note: Hover over icons to view figure legend
Homology
BLAST of F-box only protein 42 vs. Ensembl Human
Match: KLHDC2 (kelch domain containing 2 [Source:HGNC Symbol;Acc:HGNC:20231])

HSP 1 Score: 134.806 bits (338), Expect = 4.658e-34
Identity = 109/403 (27.05%), Postives = 175/403 (43.42%), Query Frame = 3
Query:  219 SFDSSKFSELIEPPM--AHVSASIGHNIFLIGGYRITFDNDLRTIIAF--DKNNLLYYNVLNSQLDTVELSYDMESVGSFPTEFFCASGMACCSNGNRIYLFGGYSLTKQEVVNALYYIEISKSIDFTGLLNIKKL-CNKKPKAVLKFLSGSYDGDSEEIHRNFPSYRDKASIVYWRNNIIVFGGYGSNFIRSEIQDNIDQGHNFLADNGEYVSGSGNRGWNNQLLIFSMSTNRWTNPATFGCIPCPRAAHSSAITDSKLFIFGGRLGMKNTAATVRSNEFYYLDLITFYWTKINLSDSASIIGRSWTTLTCVYDEVFFIVGGFSGDNVPLSDAYIVKIDNKPNVGKVTAKLRCFQSANWDPYIDRSSWNTSELFTPASRMWHSSCLAADGFIYIIGGCRNDL 1412
            +F+S +  EL  P     HV+ S G ++F+ GGY+    N +R +  F   +  L  YN+   +   +    D+             SG         +YLFGG+    +   N  Y ++ S+S D   +L  +++ C   P                      PS +DK  +  ++N +I FGGYG       + ++   G  F  D   + + S  RGWN+ + I    T  W+ P T G  P PRAAH+ A   ++ F+FGGR          R N+ +YL+L T+ W ++ +      +GRSW +LT V  +  F+ GGF+ D  PLSDA+                  C     W  +        +  +T   R+WH++C + +G + + GGC N+L
Sbjct:   17 AFESYESMELACPAERSGHVAVSDGRHMFVWGGYK---SNQVRGLYDFYLPREELWIYNMETGRWKKINTEGDVPP---------SMSGSCAVCVDRVLYLFGGHH--SRGNTNKFYMLD-SRSTD--RVLQWERIDCQGIP----------------------PSSKDKLGVWVYKNKLIFFGGYGY------LPEDKVLG-TFEFDETSFWNSSHPRGWNDHVHILDTETFTWSQPITTGKAPSPRAAHACATVGNRGFVFGGRY------RDARMNDLHYLNLDTWEWNEL-IPQGICPVGRSWHSLTPVSSDHLFLFGGFTTDKQPLSDAWTY----------------CISKNEWIQF--------NHPYTEKPRLWHTACASDEGEVIVFGGCANNL 342          
BLAST of F-box only protein 42 vs. Ensembl Human
Match: KLHDC2 (kelch domain containing 2 [Source:HGNC Symbol;Acc:HGNC:20231])

HSP 1 Score: 135.576 bits (340), Expect = 6.213e-34
Identity = 118/440 (26.82%), Postives = 186/440 (42.27%), Query Frame = 3
Query:  219 SFDSSKFSELIEPPM--AHVSASIGHNIFLIGGYRITFDNDLRTIIAF--DKNNLLYYNVLNSQLDTVELSYDMESVGSFPTEFFCASGMACCSNGNRIYLFGGYSLTKQEVVNALYYIEISKSIDFTGLLNIKKL-CNKKPKAVLKFLSGSYDGDSEEIHRNFPSYRDKASIVYWRNNIIVFGGYGSNFIRSEIQDNIDQGHNFLADNGEYVSGSGNRGWNNQLLIFSMSTNRWTNPATFGCIPCPRAAHSSAITDSKLFIFGGRLGMKNTAATVRSNEFYYLDLITFYWTKINLSDSASIIGRSWTTLTCVYDEVFFIVGGFSGDNVPLSDAYIVKIDNKPNVGKVTAKLRCFQSANWDPYIDRSSWNTSELFTPASRMWHSSCLAADGFIYIIGGCRND-LASXXXXXXXXXXXXXPEPLPLYRLCLWSVFLLKPNL 1520
            +F+S +  EL  P     HV+ S G ++F+ GGY+    N +R +  F   +  L  YN+   +   +    D+             SG         +YLFGG+    +   N  Y ++ S+S D   +L  +++ C   P                      PS +DK  +  ++N +I FGGYG       + ++   G  F  D   + + S  RGWN+ + I    T  W+ P T G  P PRAAH+ A   ++ F+FGGR          R N+ +YL+L T+ W ++ +      +GRSW +LT V  +  F+ GGF+ D  PLSDA+                  C     W  +        +  +T   R+WH++C + +G + + GGC N+ L          I     +P  L RL L +V   K  L
Sbjct:   17 AFESYESMELACPAERSGHVAVSDGRHMFVWGGYK---SNQVRGLYDFYLPREELWIYNMETGRWKKINTEGDVPP---------SMSGSCAVCVDRVLYLFGGHH--SRGNTNKFYMLD-SRSTD--RVLQWERIDCQGIP----------------------PSSKDKLGVWVYKNKLIFFGGYGY------LPEDKVLG-TFEFDETSFWNSSHPRGWNDHVHILDTETFTWSQPITTGKAPSPRAAHACATVGNRGFVFGGRY------RDARMNDLHYLNLDTWEWNEL-IPQGICPVGRSWHSLTPVSSDHLFLFGGFTTDKQPLSDAWTY----------------CISKNEWIQF--------NHPYTEKPRLWHTACASDEGEVIVFGGCANNLLVHHRAAHSNEILIFSVQPKSLVRLSLEAVICFKEML 379          
BLAST of F-box only protein 42 vs. Ensembl Human
Match: KLHDC1 (kelch domain containing 1 [Source:HGNC Symbol;Acc:HGNC:19836])

HSP 1 Score: 130.183 bits (326), Expect = 3.582e-32
Identity = 116/423 (27.42%), Postives = 186/423 (43.97%), Query Frame = 3
Query:  225 DSSKFSELIEPPMAHVSASIGHNIFLIGGYRITFDNDLRTIIAFDKNNLLYYNVLNSQLDTVELSYDMESVGSFPTEFFCASGMACCSNGNRIYLFGGYSLTKQEVVNALYYIEISKSIDFTGLLNIKKLCNKKPKAVLKFLSGSYDGDSEEIHRNFPSYRDKASIVYWRNNIIVFGGYGSNFIRSEIQDNIDQGHNFLADNGEYVSGSGNRGWNNQLLIFSMSTNRWTNPATFGCIP-CPRAAHSSAITDSKLFIFGGRLGMKNTAATVRSNEFYYLDLITFYWTKINLSDSASIIGRSWTTLTCVYDEVFFIVGGFSGDNVPLSDAYIVKIDNKPNVGKVTAKLRCFQSANWDPYIDRSSWNTSELFTPASRMWHSSCLAADGFIYIIGGCRNDLASXXXXXXXXXXXXXPEPLPLYRLCL 1490
            DS  F  + E    H +   G+ +++ GGY    DN++     +  N+ ++   ++S L  + L   ME  G  P     + G   C NG ++Y+FGGY    +   N LY++ + ++ D T +         +P                      P+ RDK S   +++ +I FGGYG     SE+QD  D  H+   +   +       GW+N + IF   T  W  P   G +P  PRAAH+ A+  +K +IFGGR+         R N+ +YL+L T+ W+     +  S   RSW TLT + D+  F+ GG S DN+PLSD +I  +              C++               + L     R+WH++CL  +  I + GG ++DL +        +   + +P  L R CL
Sbjct:    3 DSQLFC-VAEERSGHCAVVDGNFLYVWGGYVSIEDNEV-----YLPNDEIWTYDIDSGLWRMHL---ME--GELPASMSGSCG--ACING-KLYIFGGYD--DKGYSNRLYFVNL-RTRDETYIWEKITDFEGQP----------------------PTPRDKLSCWVYKDRLIYFGGYGCRR-HSELQDCFDV-HDASWEEQIFW------GWHNDVHIFDTKTQTWFQPEIKGGVPPQPRAAHTCAVLGNKGYIFGGRV------LQTRMNDLHYLNLDTWTWSGRITINGESPKHRSWHTLTPIADDKLFLCGGLSADNIPLSDGWIHNVTTN-----------CWKQL-------------THLPKTRPRLWHTACLGKENEIMVFGGSKDDLLALDTGHCNDLLIFQTQPYSLLRSCL 348          
BLAST of F-box only protein 42 vs. Ensembl Human
Match: KLHDC2 (kelch domain containing 2 [Source:HGNC Symbol;Acc:HGNC:20231])

HSP 1 Score: 113.235 bits (282), Expect = 5.151e-27
Identity = 94/332 (28.31%), Postives = 148/332 (44.58%), Query Frame = 3
Query:  219 SFDSSKFSELIEPPM--AHVSASIGHNIFLIGGYRITFDNDLRTIIAF--DKNNLLYYNVLNSQLDTVELSYDMESVGSFPTEFFCASGMACCSNGNRIYLFGGYSLTKQEVVNALYYIEISKSIDFTGLLNIKKL-CNKKPKAVLKFLSGSYDGDSEEIHRNFPSYRDKASIVYWRNNIIVFGGYGSNFIRSEIQDNIDQGHNFLADNGEYVSGSGNRGWNNQLLIFSMSTNRWTNPATFGCIPCPRAAHSSAITDSKLFIFGGRLGMKNTAATVRSNEFYYLDLITFYWTKINLSDSASIIGRSWTTLTCVYDEVFFIVGGFSGDNVPLS 1199
            +F+S +  EL  P     HV+ S G ++F+ GGY+    N +R +  F   +  L  YN+   +   +    D+             SG         +YLFGG+    +   N  Y ++ S+S D   +L  +++ C   P                      PS +DK  +  ++N +I FGGYG       + ++   G  F  D   + + S  RGWN+ + I    T  W+ P T G  P PRAAH+ A   ++ F+FGGR          R N+ +YL+L T+ W ++ +      +GRSW +LT V  +  F+ GGF+ D  PLS
Sbjct:   17 AFESYESMELACPAERSGHVAVSDGRHMFVWGGYK---SNQVRGLYDFYLPREELWIYNMETGRWKKINTEGDVPP---------SMSGSCAVCVDRVLYLFGGHH--SRGNTNKFYMLD-SRSTDR--VLQWERIDCQGIP----------------------PSSKDKLGVWVYKNKLIFFGGYGY------LPEDKVLG-TFEFDETSFWNSSHPRGWNDHVHILDTETFTWSQPITTGKAPSPRAAHACATVGNRGFVFGGRY------RDARMNDLHYLNLDTWEWNEL-IPQGICPVGRSWHSLTPVSSDHLFLFGGFTTDKQPLS 295          
BLAST of F-box only protein 42 vs. Ensembl Human
Match: KLHDC1 (kelch domain containing 1 [Source:HGNC Symbol;Acc:HGNC:19836])

HSP 1 Score: 107.842 bits (268), Expect = 3.233e-26
Identity = 66/203 (32.51%), Postives = 97/203 (47.78%), Query Frame = 3
Query:  813 NFLADNGEYVSGSGNRGWNNQLLIFSMSTNRWTNPATFGCIP-CPRAAHSSAITDSKLFIFGGRLGMKNTAATVRSNEFYYLDLITFYWTKINLSDSASIIGRSWTTLTCVYDEVFFIVGGFSGDNVPLSDAYIVKIDNKPNVGKVTAKLRCFQSANWDPYIDRSSWNTSELFTPASRMWHSSCLAADGFIYIIGGCRNDLAS 1418
            NFL   G YV      GW+N + IF   T  W  P   G +P  PRAAH+ A+  +K +IFGGR+         R N+ +YL+L T+ W+     +  S   RSW TLT + D+  F+ GG S DN+PLSD +I  +              C++               + L     R+WH++CL  +  I + GG ++DL +
Sbjct:   23 NFLYVWGGYVEEQIFWGWHNDVHIFDTKTQTWFQPEIKGGVPPQPRAAHTCAVLGNKGYIFGGRV------LQTRMNDLHYLNLDTWTWSGRITINGESPKHRSWHTLTPIADDKLFLCGGLSADNIPLSDGWIHNVTTN-----------CWKQL-------------THLPKTRPRLWHTACLGKENEIMVFGGSKDDLLA 195          
BLAST of F-box only protein 42 vs. Ensembl Celegans
Match: F53E4.1 (pep chromosome:WBcel235:V:15652438:15659079:-1 gene:WBGene00009978.1 transcript:F53E4.1b.2 gene_biotype:protein_coding transcript_biotype:protein_coding gene_symbol:F53E4.1)

HSP 1 Score: 57.3806 bits (137), Expect = 1.559e-8
Identity = 58/244 (23.77%), Postives = 94/244 (38.52%), Query Frame = 3
Query:  678 EIHRNFPSYRDKASIVYWRNNIIVFGGYGSNFIRSEIQDNIDQGHNFLADNGEYVSGSGNRGWNNQLLIFSMSTNRWTNPATFGCIPCPRAAHSSAITDSKLFIFGGR---LGMKNTAATVRSNEFYYLDLITFYWTKINLSDSASIIGRSWTTLTCVYDEVFFIVGGFSGD-NVPLSDAYIVKIDNKPNVGKVTAKLRCFQSANWDPYIDRSSWNTSELFTPASRMWHSSCLAADGFIYIIGG 1397
            EI    P  RD  + V W N + VFGGY  +  R                            ++ +  +F  +T+ W    T    P  R  H++++ D  ++IFGGR    G  +T      +    L+L T  WT+  + ++    G   +  T VYD   ++ GG+ G  NV  ++ Y                  CF     DP     S  +     P++R  H S + ++G +Y+ GG
Sbjct:  135 EIEGFVPPSRDGHTAVVWNNQMFVFGGYEEDAQR----------------------------FSQETYVFDFATSTWREMHTKNDPPRWRDFHTASVIDGMMYIFGGRSDESGQFHTIHDQYDDTLMALNLATGAWTRTKVPENTMKPGGRRSHSTWVYDGKMYMFGGYLGTINVHYNELY------------------CF-----DPKTSMWSVISVRGTYPSARRRHCSVV-SNGKVYLFGG 326          
BLAST of F-box only protein 42 vs. Ensembl Celegans
Match: F53E4.1 (pep chromosome:WBcel235:V:15652438:15659067:-1 gene:WBGene00009978.1 transcript:F53E4.1b.1 gene_biotype:protein_coding transcript_biotype:protein_coding gene_symbol:F53E4.1)

HSP 1 Score: 57.3806 bits (137), Expect = 1.559e-8
Identity = 58/244 (23.77%), Postives = 94/244 (38.52%), Query Frame = 3
Query:  678 EIHRNFPSYRDKASIVYWRNNIIVFGGYGSNFIRSEIQDNIDQGHNFLADNGEYVSGSGNRGWNNQLLIFSMSTNRWTNPATFGCIPCPRAAHSSAITDSKLFIFGGR---LGMKNTAATVRSNEFYYLDLITFYWTKINLSDSASIIGRSWTTLTCVYDEVFFIVGGFSGD-NVPLSDAYIVKIDNKPNVGKVTAKLRCFQSANWDPYIDRSSWNTSELFTPASRMWHSSCLAADGFIYIIGG 1397
            EI    P  RD  + V W N + VFGGY  +  R                            ++ +  +F  +T+ W    T    P  R  H++++ D  ++IFGGR    G  +T      +    L+L T  WT+  + ++    G   +  T VYD   ++ GG+ G  NV  ++ Y                  CF     DP     S  +     P++R  H S + ++G +Y+ GG
Sbjct:  135 EIEGFVPPSRDGHTAVVWNNQMFVFGGYEEDAQR----------------------------FSQETYVFDFATSTWREMHTKNDPPRWRDFHTASVIDGMMYIFGGRSDESGQFHTIHDQYDDTLMALNLATGAWTRTKVPENTMKPGGRRSHSTWVYDGKMYMFGGYLGTINVHYNELY------------------CF-----DPKTSMWSVISVRGTYPSARRRHCSVV-SNGKVYLFGG 326          
BLAST of F-box only protein 42 vs. Ensembl Celegans
Match: F53E4.1 (pep chromosome:WBcel235:V:15652438:15668300:-1 gene:WBGene00009978.1 transcript:F53E4.1d.1 gene_biotype:protein_coding transcript_biotype:protein_coding gene_symbol:F53E4.1)

HSP 1 Score: 55.4546 bits (132), Expect = 7.825e-8
Identity = 58/251 (23.11%), Postives = 97/251 (38.65%), Query Frame = 3
Query:  678 EIHRNFPSYRDKASIVYWRNNIIVFGGYGSNFIRSEIQDNIDQGHNFLADNGEYVSGSGNRGWNNQLLIFSMSTNRWTNPATFGCIPCPRAAHSSAITDSKLFIFGGR------LGMKNTAATVR---SNEFYYLDLITFYWTKINLSDSASIIGRSWTTLTCVYDEVFFIVGGFSGD-NVPLSDAYIVKIDNKPNVGKVTAKLRCFQSANWDPYIDRSSWNTSELFTPASRMWHSSCLAADGFIYIIGGC 1400
            EI    P  RD  + V W N + VFGGY  +  R                            ++ +  +F  +T+ W    T    P  R  H++++ D  ++IFGGR      +G ++   T+     +    L+L T  WT+  + ++    G   +  T VYD   ++ GG+ G  NV  ++ Y                  CF     DP     S  +     P++R  H S + ++G +Y+ GG 
Sbjct:  141 EIEGFVPPSRDGHTAVVWNNQMFVFGGYEEDAQR----------------------------FSQETYVFDFATSTWREMHTKNDPPRWRDFHTASVIDGMMYIFGGRSDESGQVGDEHLFHTIHDQYDDTLMALNLATGAWTRTKVPENTMKPGGRRSHSTWVYDGKMYMFGGYLGTINVHYNELY------------------CF-----DPKTSMWSVISVRGTYPSARRRHCSVV-SNGKVYLFGGT 339          
BLAST of F-box only protein 42 vs. Ensembl Celegans
Match: F53E4.1 (pep chromosome:WBcel235:V:15652438:15659079:-1 gene:WBGene00009978.1 transcript:F53E4.1a.2 gene_biotype:protein_coding transcript_biotype:protein_coding gene_symbol:F53E4.1)

HSP 1 Score: 55.4546 bits (132), Expect = 8.207e-8
Identity = 58/251 (23.11%), Postives = 97/251 (38.65%), Query Frame = 3
Query:  678 EIHRNFPSYRDKASIVYWRNNIIVFGGYGSNFIRSEIQDNIDQGHNFLADNGEYVSGSGNRGWNNQLLIFSMSTNRWTNPATFGCIPCPRAAHSSAITDSKLFIFGGR------LGMKNTAATVR---SNEFYYLDLITFYWTKINLSDSASIIGRSWTTLTCVYDEVFFIVGGFSGD-NVPLSDAYIVKIDNKPNVGKVTAKLRCFQSANWDPYIDRSSWNTSELFTPASRMWHSSCLAADGFIYIIGGC 1400
            EI    P  RD  + V W N + VFGGY  +  R                            ++ +  +F  +T+ W    T    P  R  H++++ D  ++IFGGR      +G ++   T+     +    L+L T  WT+  + ++    G   +  T VYD   ++ GG+ G  NV  ++ Y                  CF     DP     S  +     P++R  H S + ++G +Y+ GG 
Sbjct:  135 EIEGFVPPSRDGHTAVVWNNQMFVFGGYEEDAQR----------------------------FSQETYVFDFATSTWREMHTKNDPPRWRDFHTASVIDGMMYIFGGRSDESGQVGDEHLFHTIHDQYDDTLMALNLATGAWTRTKVPENTMKPGGRRSHSTWVYDGKMYMFGGYLGTINVHYNELY------------------CF-----DPKTSMWSVISVRGTYPSARRRHCSVV-SNGKVYLFGGT 333          
BLAST of F-box only protein 42 vs. Ensembl Celegans
Match: F53E4.1 (pep chromosome:WBcel235:V:15652438:15659067:-1 gene:WBGene00009978.1 transcript:F53E4.1a.1 gene_biotype:protein_coding transcript_biotype:protein_coding gene_symbol:F53E4.1)

HSP 1 Score: 55.4546 bits (132), Expect = 8.207e-8
Identity = 58/251 (23.11%), Postives = 97/251 (38.65%), Query Frame = 3
Query:  678 EIHRNFPSYRDKASIVYWRNNIIVFGGYGSNFIRSEIQDNIDQGHNFLADNGEYVSGSGNRGWNNQLLIFSMSTNRWTNPATFGCIPCPRAAHSSAITDSKLFIFGGR------LGMKNTAATVR---SNEFYYLDLITFYWTKINLSDSASIIGRSWTTLTCVYDEVFFIVGGFSGD-NVPLSDAYIVKIDNKPNVGKVTAKLRCFQSANWDPYIDRSSWNTSELFTPASRMWHSSCLAADGFIYIIGGC 1400
            EI    P  RD  + V W N + VFGGY  +  R                            ++ +  +F  +T+ W    T    P  R  H++++ D  ++IFGGR      +G ++   T+     +    L+L T  WT+  + ++    G   +  T VYD   ++ GG+ G  NV  ++ Y                  CF     DP     S  +     P++R  H S + ++G +Y+ GG 
Sbjct:  135 EIEGFVPPSRDGHTAVVWNNQMFVFGGYEEDAQR----------------------------FSQETYVFDFATSTWREMHTKNDPPRWRDFHTASVIDGMMYIFGGRSDESGQVGDEHLFHTIHDQYDDTLMALNLATGAWTRTKVPENTMKPGGRRSHSTWVYDGKMYMFGGYLGTINVHYNELY------------------CF-----DPKTSMWSVISVRGTYPSARRRHCSVV-SNGKVYLFGGT 333          
BLAST of F-box only protein 42 vs. Ensembl Fly
Match: CG12081 (gene:FBgn0030053 transcript:FBtr0332626)

HSP 1 Score: 49.2914 bits (116), Expect = 8.030e-6
Identity = 68/325 (20.92%), Postives = 117/325 (36.00%), Query Frame = 3
Query:  267 HVSASIGHNIFLIGGYRITFD---NDLRTIIAFDKNNLLYYNVLNSQLDTVELSYDMESVGSFPTEFFCASGMACCSNGNRIYLFGGYSLTKQEVVNALYYIEISKSIDFTGLLNIKKLCNKKPKAVLKFLSGSYDGDS----------------------EEIH------------RNF---PSYRD-KASIVYWRNNIIVFGGYGSNFIRSEIQDNIDQGHNFLADNGEYVSGSGNRGWNNQLLIFSMSTNRWTNPATFGCIPCPRAAHSSAITDSKLFIFGGRLGMKNTAATVRSNEFYYLDLITFYWTKINLSDSASIIGR 1118
            H +  +G  I+  GGY   +D   N+   + A + + + +  ++  QLD   +         +P   F   G    +  +RIY++GG +   + + N LY              + K     +P+ V   L G+ DG S                       ++H            + F   PSYRD  AS+ Y +  + +FGG G        Q+                       + ++++   M T  W  P T G +P  R +HS  + +  +++FGG  G+ +       N+ Y  D  T  W  I  +  A    R
Sbjct:   16 HAAVGVGDFIYSFGGYCTGYDYRYNEPIDVHALNAHTMRW-TLVPQQLDDAGVPL------KYPLVPFQRYGHTVVAYKDRIYIWGGRN--DENLCNTLY------------CFDPKTAQWSRPQ-VTGCLPGARDGHSACVIGNSMYIFGGFVDEINEFSSDVHSLNLDTMEWRYVQTFGVPPSYRDFHASVAYEQERMYIFGGRGDKHSPYHSQEET---------------------YCHEIVYLDMKTKVWHRPFTAGKVPVGRRSHSMFVYNKLIYVFGGYNGLLDQ----HFNDLYTFDPRTKLWNLIRANGKAPTARR 293          
BLAST of F-box only protein 42 vs. Ensembl Fly
Match: CG12081 (gene:FBgn0030053 transcript:FBtr0071218)

HSP 1 Score: 49.2914 bits (116), Expect = 8.030e-6
Identity = 68/325 (20.92%), Postives = 117/325 (36.00%), Query Frame = 3
Query:  267 HVSASIGHNIFLIGGYRITFD---NDLRTIIAFDKNNLLYYNVLNSQLDTVELSYDMESVGSFPTEFFCASGMACCSNGNRIYLFGGYSLTKQEVVNALYYIEISKSIDFTGLLNIKKLCNKKPKAVLKFLSGSYDGDS----------------------EEIH------------RNF---PSYRD-KASIVYWRNNIIVFGGYGSNFIRSEIQDNIDQGHNFLADNGEYVSGSGNRGWNNQLLIFSMSTNRWTNPATFGCIPCPRAAHSSAITDSKLFIFGGRLGMKNTAATVRSNEFYYLDLITFYWTKINLSDSASIIGR 1118
            H +  +G  I+  GGY   +D   N+   + A + + + +  ++  QLD   +         +P   F   G    +  +RIY++GG +   + + N LY              + K     +P+ V   L G+ DG S                       ++H            + F   PSYRD  AS+ Y +  + +FGG G        Q+                       + ++++   M T  W  P T G +P  R +HS  + +  +++FGG  G+ +       N+ Y  D  T  W  I  +  A    R
Sbjct:   16 HAAVGVGDFIYSFGGYCTGYDYRYNEPIDVHALNAHTMRW-TLVPQQLDDAGVPL------KYPLVPFQRYGHTVVAYKDRIYIWGGRN--DENLCNTLY------------CFDPKTAQWSRPQ-VTGCLPGARDGHSACVIGNSMYIFGGFVDEINEFSSDVHSLNLDTMEWRYVQTFGVPPSYRDFHASVAYEQERMYIFGGRGDKHSPYHSQEET---------------------YCHEIVYLDMKTKVWHRPFTAGKVPVGRRSHSMFVYNKLIYVFGGYNGLLDQ----HFNDLYTFDPRTKLWNLIRANGKAPTARR 293          
BLAST of F-box only protein 42 vs. Ensembl Zebrafish
Match: krcp (kelch repeat-containing protein [Source:ZFIN;Acc:ZDB-GENE-030131-2126])

HSP 1 Score: 58.5362 bits (140), Expect = 1.576e-8
Identity = 37/122 (30.33%), Postives = 59/122 (48.36%), Query Frame = 3
Query:  861 GWNNQLLIFSMSTNRWTNPATFGCIPCPRAAHSSAITDSKLFIFGGRLGMKNTAATVRSNEFYYLDLITFYWTKINLSDSASIIGRSWTTLTCVYDEVFFIVGGFSGDNVPLSDAYIVKIDN 1226
            G ++ + IF+     W  P   G  P PR+ HS+ +   ++F+FGG          V  N+ + LDL    ++ +  S +A    RSW     + +  F I GG++G+N  LSDA+I   D 
Sbjct:  350 GCSDSIYIFNPEMAIWYQPIVNGEKPAPRSGHSACVMQGRIFVFGG------WDTPVCFNDMFMLDLGLMEFSPVKTSGTAPSP-RSWHGCAVLSESSFLIHGGYNGNNA-LSDAFIFNTDT 463          
BLAST of F-box only protein 42 vs. Ensembl Zebrafish
Match: lztr1 (leucine-zipper-like transcription regulator 1 [Source:ZFIN;Acc:ZDB-GENE-030131-9564])

HSP 1 Score: 56.9954 bits (136), Expect = 5.316e-8
Identity = 46/176 (26.14%), Postives = 75/176 (42.61%), Query Frame = 3
Query:  705 RDKASIVYWRNNIIVFGGYGSNFIRSEIQDNIDQGHNFLADNGEYVSGSGNRGWNNQLLIFSMSTNRWTNPATFGCIPCPRAAHSSAITDSKLFIFGGRLGMKNTAATVR-SNEFYYLDLITFYWTKINLSDSASIIGRSWTTLTCVYDEVFFIVGGFSGDNVPLSDAYIVKIDNK 1229
            R K ++V +R+ I VFGG              D G N L                N LL F +    W    T G  P PR  HS+ +  S +F+FGG  G   + + ++  N+ +     T  WT+  +     ++ RS    T VY++  +I  G+ G N  L+D + + + ++
Sbjct:   51 RSKHTVVAYRDAIYVFGG--------------DNGKNML----------------NDLLRFDVKDCSWCRAFTTGTPPAPRYHHSAVVYGSSMFVFGGYTGDIYSNSNLKNKNDLFEYKFATGQWTEWKV--EGRLVARSAHGAT-VYNDKLWIFAGYDG-NARLNDMWTIGLQDR 192          
BLAST of F-box only protein 42 vs. Ensembl Zebrafish
Match: lztr1 (leucine-zipper-like transcription regulator 1 [Source:ZFIN;Acc:ZDB-GENE-030131-9564])

HSP 1 Score: 56.9954 bits (136), Expect = 5.743e-8
Identity = 46/176 (26.14%), Postives = 75/176 (42.61%), Query Frame = 3
Query:  705 RDKASIVYWRNNIIVFGGYGSNFIRSEIQDNIDQGHNFLADNGEYVSGSGNRGWNNQLLIFSMSTNRWTNPATFGCIPCPRAAHSSAITDSKLFIFGGRLGMKNTAATVR-SNEFYYLDLITFYWTKINLSDSASIIGRSWTTLTCVYDEVFFIVGGFSGDNVPLSDAYIVKIDNK 1229
            R K ++V +R+ I VFGG              D G N L                N LL F +    W    T G  P PR  HS+ +  S +F+FGG  G   + + ++  N+ +     T  WT+  +     ++ RS    T VY++  +I  G+ G N  L+D + + + ++
Sbjct:   51 RSKHTVVAYRDAIYVFGG--------------DNGKNML----------------NDLLRFDVKDCSWCRAFTTGTPPAPRYHHSAVVYGSSMFVFGGYTGDIYSNSNLKNKNDLFEYKFATGQWTEWKV--EGRLVARSAHGAT-VYNDKLWIFAGYDG-NARLNDMWTIGLQDR 192          
BLAST of F-box only protein 42 vs. Ensembl Zebrafish
Match: lztr1 (leucine-zipper-like transcription regulator 1 [Source:ZFIN;Acc:ZDB-GENE-030131-9564])

HSP 1 Score: 56.9954 bits (136), Expect = 5.965e-8
Identity = 46/176 (26.14%), Postives = 75/176 (42.61%), Query Frame = 3
Query:  705 RDKASIVYWRNNIIVFGGYGSNFIRSEIQDNIDQGHNFLADNGEYVSGSGNRGWNNQLLIFSMSTNRWTNPATFGCIPCPRAAHSSAITDSKLFIFGGRLGMKNTAATVR-SNEFYYLDLITFYWTKINLSDSASIIGRSWTTLTCVYDEVFFIVGGFSGDNVPLSDAYIVKIDNK 1229
            R K ++V +R+ I VFGG              D G N L                N LL F +    W    T G  P PR  HS+ +  S +F+FGG  G   + + ++  N+ +     T  WT+  +     ++ RS    T VY++  +I  G+ G N  L+D + + + ++
Sbjct:   58 RSKHTVVAYRDAIYVFGG--------------DNGKNML----------------NDLLRFDVKDCSWCRAFTTGTPPAPRYHHSAVVYGSSMFVFGGYTGDIYSNSNLKNKNDLFEYKFATGQWTEWKV--EGRLVARSAHGAT-VYNDKLWIFAGYDG-NARLNDMWTIGLQDR 199          
BLAST of F-box only protein 42 vs. Ensembl Zebrafish
Match: zgc:163014 (zgc:163014 [Source:ZFIN;Acc:ZDB-GENE-070424-100])

HSP 1 Score: 49.2914 bits (116), Expect = 8.887e-6
Identity = 41/140 (29.29%), Postives = 60/140 (42.86%), Query Frame = 3
Query:  858 RGWNNQLLIFSMSTNRWTNPATFGCIPCPRAAHSSAITDSKLFIFGGRLGMKNTAATVRSNEFYYLDLITFYWTKINLSDSASIIGRSWTTLTCVYDEVFFIVGGFSGDNVPLSDAYIVKIDNKPNVGKVTAKLRCFQSA 1277
            R  +N L IF+     W  P   G  P PR  HS+ +  +K+ IFGGR     TA  +  N+ + LDL    +T +   ++   + R +     V D    I GG S     L D ++  ID+      V+  L C   A
Sbjct:  152 RVCSNALYIFNPEHGLWYQPIVEGDRPLPRFGHSTTLLSNKMVIFGGR----KTATYL--NDLHILDLGFMEYTAVK-HENMPPLARGFHAALPVSDNRVLISGGCSAVGA-LQDLHLFNIDSSSWTSLVSPSLCCKPRA 283          
BLAST of F-box only protein 42 vs. Ensembl Xenopus
Match: polr2b (polymerase (RNA) II (DNA directed) polypeptide B, 140kDa [Source:Xenbase;Acc:XB-GENE-1012874])

HSP 1 Score: 143.28 bits (360), Expect = 1.161e-36
Identity = 113/423 (26.71%), Postives = 186/423 (43.97%), Query Frame = 3
Query:  264 AHVSASIGHNIFLIGGYRITFDNDLRTIIAF--DKNNLLYYNVLNSQLDTVELSYDMESVGSFPTEFFCASGMACCSNGNRIYLFGGYSLTKQEVVNALYYIEISKSIDFTGLLNIKKL-CNKKPKAVLKFLSGSYDGDSEEIHRNFPSYRDKASIVYWRNNIIVFGGYGSNFIRSEIQDNIDQGHNFLADNGEYVSGSGNRGWNNQLLIFSMSTNRWTNPATFGCIPCPRAAHSSAITDSKLFIFGGRLGMKNTAATVRSNEFYYLDLITFYWTKINLSDSASIIGRSWTTLTCVYDEVFFIVGGFSGDNVPLSDAYIVKIDNKPNVGKVTAKLRCFQSANWDPYIDRSSWNTSELFTPASRMWHSSCLAADGFIYIIGGCRNDLASXXXXXXXXXXXXXP-EPLPLYRLCLWSVFLLKPNL 1520
             HV+ + G +IF+ GGY+   +  +R    F   ++ +  Y++ N     V+      + G  P      SG         +YLFGG+        N  Y + ++      G L  +K+ C   P                      PS +DK  +  ++N ++ FGGYG        Q++I     F  D   + +    RGWNN + + ++    W  P T G  P PRAAHS A  +++ ++FGGR          R N+ YYL+  T+ W ++ ++   + +GRSW +LT    +  F+ GGF+ D  PLSDA+I ++                 +  W P+++  S           R+WH++C + +G I++ GGC N+L +      +    + P +P  L RLCL +V L K  L
Sbjct:   37 GHVAVTDGQSIFVWGGYK---NAPVRGFYDFYLPRDEIWIYDMENGSWQRVK------TKGEIP---LSMSGSCAACVDKVLYLFGGHHAHGN--TNMFYMLNLNPR---DGDLFWEKVDCKGIP----------------------PSPKDKLGVWTYKNKLVYFGGYGY------YQEDIVGTFEF--DETSFGNVGLPRGWNNHVHVLNLDNFTWERPVTTGKSPSPRAAHSCATVENRGYVFGGRY------RDSRMNDMYYLNFSTWEWHEV-ITQGGNPVGRSWHSLTQASSDSLFLFGGFTTDKQPLSDAWIYRL----------------STNEWIPFMNHHS--------EKPRLWHTACGSKEGEIFVFGGCANNLLAHHRAAHSNEVLVFPVQPKSLVRLCLETVILFKEML 381          
BLAST of F-box only protein 42 vs. Ensembl Xenopus
Match: polr2b (polymerase (RNA) II (DNA directed) polypeptide B, 140kDa [Source:Xenbase;Acc:XB-GENE-1012874])

HSP 1 Score: 142.124 bits (357), Expect = 2.995e-36
Identity = 113/422 (26.78%), Postives = 183/422 (43.36%), Query Frame = 3
Query:  264 AHVSASIGHNIFLIGGYRITFDNDLRTIIAFDKNNLLY-YNVLNSQLDTVELSYDMESVGSFPTEFFCASGMACCSNGNRIYLFGGYSLTKQEVVNALYYIEISKSIDFTGLLNIKKL-CNKKPKAVLKFLSGSYDGDSEEIHRNFPSYRDKASIVYWRNNIIVFGGYGSNFIRSEIQDNIDQGHNFLADNGEYVSGSGNRGWNNQLLIFSMSTNRWTNPATFGCIPCPRAAHSSAITDSKLFIFGGRLGMKNTAATVRSNEFYYLDLITFYWTKINLSDSASIIGRSWTTLTCVYDEVFFIVGGFSGDNVPLSDAYIVKIDNKPNVGKVTAKLRCFQSANWDPYIDRSSWNTSELFTPASRMWHSSCLAADGFIYIIGGCRNDLASXXXXXXXXXXXXXP-EPLPLYRLCLWSVFLLKPNL 1520
             HV+ + G +IF+ GGY++         +  D    LY Y      +    L   +++ G  P      SG         +YLFGG+        N  Y + ++      G L  +K+ C   P                      PS +DK  +  ++N ++ FGGYG        Q++I     F  D   + +    RGWNN + + ++    W  P T G  P PRAAHS A  +++ ++FGGR          R N+ YYL+  T+ W ++ ++   + +GRSW +LT    +  F+ GGF+ D  PLSDA+I ++                 +  W P+++  S           R+WH++C + +G I++ GGC N+L +      +    + P +P  L RLCL +V L K  L
Sbjct:   37 GHVAVTDGQSIFVWGGYKV---------LRGDWGGYLYIYKYKIKSIYCFILRQRVKTKGEIP---LSMSGSCAACVDKVLYLFGGHHAHGN--TNMFYMLNLNPR---DGDLFWEKVDCKGIP----------------------PSPKDKLGVWTYKNKLVYFGGYGY------YQEDIVGTFEF--DETSFGNVGLPRGWNNHVHVLNLDNFTWERPVTTGKSPSPRAAHSCATVENRGYVFGGRY------RDSRMNDMYYLNFSTWEWHEV-ITQGGNPVGRSWHSLTQASSDSLFLFGGFTTDKQPLSDAWIYRL----------------STNEWIPFMNHHS--------EKPRLWHTACGSKEGEIFVFGGCANNLLAHHRAAHSNEVLVFPVQPKSLVRLCLETVILFKEML 380          
BLAST of F-box only protein 42 vs. Ensembl Xenopus
Match: polr2b (polymerase (RNA) II (DNA directed) polypeptide B, 140kDa [Source:Xenbase;Acc:XB-GENE-1012874])

HSP 1 Score: 139.043 bits (349), Expect = 1.626e-35
Identity = 84/276 (30.43%), Postives = 136/276 (49.28%), Query Frame = 3
Query:  696 PSYRDKASIVYWRNNIIVFGGYGSNFIRSEIQDNIDQGHNFLADNGEYVSGSGNRGWNNQLLIFSMSTNRWTNPATFGCIPCPRAAHSSAITDSKLFIFGGRLGMKNTAATVRSNEFYYLDLITFYWTKINLSDSASIIGRSWTTLTCVYDEVFFIVGGFSGDNVPLSDAYIVKIDNKPNVGKVTAKLRCFQSANWDPYIDRSSWNTSELFTPASRMWHSSCLAADGFIYIIGGCRNDLASXXXXXXXXXXXXXP-EPLPLYRLCLWSVFLLKPNL 1520
            PS +DK  +  ++N ++ FGGYG        Q++I     F  D   + +    RGWNN + + ++    W  P T G  P PRAAHS A  +++ ++FGGR          R N+ YYL+  T+ W ++ ++   + +GRSW +LT    +  F+ GGF+ D  PLSDA+I ++                 +  W P+++  S           R+WH++C + +G I++ GGC N+L +      +    + P +P  L RLCL +V L K  L
Sbjct:  107 PSPKDKLGVWTYKNKLVYFGGYGY------YQEDIVGTFEF--DETSFGNVGLPRGWNNHVHVLNLDNFTWERPVTTGKSPSPRAAHSCATVENRGYVFGGRY------RDSRMNDMYYLNFSTWEWHEV-ITQGGNPVGRSWHSLTQASSDSLFLFGGFTTDKQPLSDAWIYRL----------------STNEWIPFMNHHS--------EKPRLWHTACGSKEGEIFVFGGCANNLLAHHRAAHSNEVLVFPVQPKSLVRLCLETVILFKEML 343          
BLAST of F-box only protein 42 vs. Ensembl Xenopus
Match: trpm6 (transient receptor potential cation channel, subfamily M, member 6 [Source:Xenbase;Acc:XB-GENE-958179])

HSP 1 Score: 65.4698 bits (158), Expect = 1.773e-10
Identity = 66/257 (25.68%), Postives = 106/257 (41.25%), Query Frame = 3
Query:  480 CCSNGNRIYLFGGYSLTKQEVVNALYYIEISKSIDFTGLLNIKKLCNKKPKAVLKFLSGSYDGDSEEIH-RNFPSYRDKASIVY------WRNNIIVFGGYGSNFIRSEIQDNIDQGHNFLADNGEYVSGSGNRGWNNQLLIFSMSTNRWTNPATFGCIPCPRAAHSSAITDSKLFIFGGRLGMKNTAATVRSNEFYYLDLITFYWTKINLSDSASIIG-RSWTTLTCVYDEVFFIVGGFSGDNVPLSDAYIVKIDN 1226
            C  +     L GG    +Q   ++L+ +EI     F     + KLC        +  + ++D +++++        R K + VY      W+  ++   G               + + F    G   S SG     N L IF+   N W  P   G  P PR  H++ +  +++ IFGGR     + + V  N+ Y LDL    ++ +++S S      RS+     V D  F + GGFS    PLSDA+I  ID 
Sbjct:  269 CLCDPETAILIGGEGANQQPCKDSLWKLEIDNDFWFP----MDKLCAGPFPQSSRGHTATFDPETKKLFVYGGMKERSKFNNVYILDTVEWKWTLVTAVGKVPTLSHHSATMYQRELYVF----GGLCSQSGTESCCNSLYIFNPDYNIWYQPIVEGERPLPRFGHTATLLGNRVVIFGGR----RSPSPVYLNDLYILDLGYMEYSTVSISASMEKPSPRSFHAAVQVSDHKFLVHGGFSLLG-PLSDAFIFDIDT 512          
BLAST of F-box only protein 42 vs. Ensembl Xenopus
Match: ENSXETT00000037226.1 (rab9 effector protein with kelch motifs [Source:NCBI gene;Acc:100145144])

HSP 1 Score: 55.0694 bits (131), Expect = 2.963e-7
Identity = 38/117 (32.48%), Postives = 55/117 (47.01%), Query Frame = 3
Query:  861 GWNNQLLIFSMSTNRWTNPATFGCIPCPRAAHSSAITDSKLFIFGGRLGMKNTAATVRSNEFYYLDLITFYWTKINLSDSASIIGRSWTTLTCVYDEVFFIVGGFSGDNVPLSDAYI 1211
            G +N L IF      W  P   G  P  R+ HS+ + + +L++FGG          V  N+ Y LDL    ++ + ++ S S   R W +   V D  F I GG+ G N  LSD Y+
Sbjct:  323 GCSNLLYIFDPQHEIWYQPIVLGKTPSSRSGHSACLLNRELYVFGG------WDTPVCYNDLYVLDLGLMEFSLVEVTGS-SPSPRCWHSAAPVSDFQFLIHGGYDG-NQALSDTYL 431          
BLAST of F-box only protein 42 vs. Ensembl Mouse
Match: Klhdc2 (kelch domain containing 2 [Source:MGI Symbol;Acc:MGI:1916804])

HSP 1 Score: 135.576 bits (340), Expect = 3.382e-34
Identity = 118/443 (26.64%), Postives = 185/443 (41.76%), Query Frame = 3
Query:  219 SFDSSKFSELIEPPM--AHVSASIGHNIFLIGGYRITFDNDLRTIIAF--DKNNLLYYNVLNSQLDTVELSYDMESVGSFPTEFFCASGMACCSNGNRIYLFGGYSLTKQEVVNALYYIEISKSIDFTGLLNIKKLCNKKPKAVLKFLSGSYDGDSEEIHRNFPSYRDKASIVYWRNNIIVFGGYGSNFIRSEIQDNIDQGHNFLADNGEYVSGSGNRGWNNQLLIFSMSTNRWTNPATFGCIPCPRAAHSSAITDSKLFIFGGRLGMKNTAATVRSNEFYYLDLITFYWTKINLSDSASIIGRSWTTLTCVYDEVFFIVGGFSGDNVPLSDAYIVKIDNKPNVGKVTAKLRCFQSANW----DPYIDRSSWNTSELFTPASRMWHSSCLAADGFIYIIGGCRND-LASXXXXXXXXXXXXXPEPLPLYRLCLWSVFLLKPNL 1520
            +F++ +  EL  P     HV+ S G ++F+ GGY+    N +R +  F   +  L  YN+   +   +    D+             SG         +YLFGG+    +   N  Y ++ S+S D  GL   +  C   P                      PS +DK  +  ++N +I FGGYG       + ++   G  F  D   + + S  RGWN+ + I    T  W+ P T G  P PRAAH+ A   +K F+FGGR          R N+ +YL+L T+ W ++ +      +GRSW +LT V  +  F+ GGF+ +  PLSDA+                  C     W     PY+++             R+WH++C + +G + + GGC N+ L          +     +P  L RL L +V   K  L
Sbjct:   17 AFENYEAMELACPAERSGHVAVSDGRHMFVWGGYK---SNQVRGLYDFYLPREELWIYNMETGRWKKINTEGDVPP---------SMSGSCAVCVDRVLYLFGGHH--SRGNTNKFYMLD-SRSAD-RGLQWERIDCQGIP----------------------PSSKDKLGVWVYKNKLIFFGGYGY------LPEDKVLG-TFEFDETSFWNSSHPRGWNDHVHILDTETFAWSQPITTGKAPSPRAAHACATVGNKGFVFGGRY------RDARMNDLHYLNLDTWEWNEL-IPQGVCPVGRSWHSLTPVSSDHLFLFGGFTTEKQPLSDAWTY----------------CISKNEWIQFNHPYVEK------------PRLWHTACASDEGEVIVFGGCANNLLVHHRAAHSNEVLIFSVQPKSLVRLSLEAVICFKEML 379          
BLAST of F-box only protein 42 vs. Ensembl Mouse
Match: Klhdc1 (kelch domain containing 1 [Source:MGI Symbol;Acc:MGI:2672853])

HSP 1 Score: 132.88 bits (333), Expect = 3.702e-33
Identity = 119/445 (26.74%), Postives = 195/445 (43.82%), Query Frame = 3
Query:  246 LIEPPMAHVSASIGHNIFLIGGYRITFDNDLRTIIAFDKNNLLYYNVLNSQLDTVELSYDMESVGSFPTEFFCASGMACCSNGNRIYLFGGYSLTKQEVVNALYYIEISKSIDFTGLLNIKKLCNKKPKAVLKFLSGSYDGDSEEIHRNFPSYRDKASIVYWRNNIIVFGGYGSNFIRSEIQDNIDQGHNFLADNGEYVSGSGNRGWNNQLLIFSMSTNRWTNPATFGCIP-CPRAAHSSAITDSKLFIFGGRLGMKNTAATVRSNEFYYLDLITFYWTKINLSDSASIIGRSWTTLTCVYDEVFFIVGGFSGDNVPLSDAYIVKIDNKPNVGKVTAKLRCFQSANWDPYIDRSSWNTSELFTPASRMWHSSCLAADGFIYIIGGCRNDLASXXXXXXXXXXXXXPEPLPLYRLCLWSV----FLLKPNLNEHEIPQKLFNDLLS 1565
            + E    H +   GH +++ GGY    DN++     +  N+ ++   ++S L  + L   ME  G  P     + G   C +G R+Y+FGGY    +   N LY++ +       G    +K+               +DG         P+ RDK S   +++ +I FGGYG     SE+Q+  D  H+   +   +       GW+N + +F   T  W+ P   G +P  PRAAHS A+  +K ++FGGR+         R N+ +YL+L T+ W+     +  S   RSW TLT + D+  F+ GG + DN+PLSD +I  I              C++     PY                R+WH++CL  +  I + GG +++L          +   + +P  L R CL  +     +LK  ++   +P KL   +L 
Sbjct:    9 VAEERSGHCAVVDGHFLYVWGGYVSIEDNEV-----YLPNDEMWTYDIDSGLWKMHL---ME--GELPPSMSGSCG--ACIHG-RLYVFGGYD--DKGYSNRLYFVNLRTR---DGTYTWEKIT-------------KFDGQP-------PTPRDKLSCWVYKDRLIYFGGYGYRR-HSELQECFDV-HDASWEEQIFW------GWHNDVHVFDTKTRTWSQPEIKGGVPPQPRAAHSCAVLGNKGYVFGGRV------LQTRMNDLHYLNLDTWVWSGRISVNGESPKHRSWHTLTAITDDKLFLFGGLNADNIPLSDGWIHNITTN-----------CWKQLRHLPYT-------------RPRLWHTACLGKENEIMVFGGSKDNLLFLDTGHCNDLLIFQTQPYSLLRSCLDCIGKNAIILKSQIS--LLPPKLLQQVLK 375          
BLAST of F-box only protein 42 vs. Ensembl Mouse
Match: Klhdc1 (kelch domain containing 1 [Source:MGI Symbol;Acc:MGI:2672853])

HSP 1 Score: 117.472 bits (293), Expect = 9.359e-29
Identity = 96/326 (29.45%), Postives = 153/326 (46.93%), Query Frame = 3
Query:  246 LIEPPMAHVSASIGHNIFLIGGYRITFDNDLRTIIAFDKNNLLYYNVLNSQLDTVELSYDMESVGSFPTEFFCASGMACCSNGNRIYLFGGYSLTKQEVVNALYYIEISKSIDFTGLLNIKKLCNKKPKAVLKFLSGSYDGDSEEIHRNFPSYRDKASIVYWRNNIIVFGGYGSNFIRSEIQDNIDQGHNFLADNGEYVSGSGNRGWNNQLLIFSMSTNRWTNPATFGCIP-CPRAAHSSAITDSKLFIFGGRLGMKNTAATVRSNEFYYLDLITFYWTKINLSDSASIIGRSWTTLTCVYDEVFFIVGGFSGDNVPLSDAYIVKI 1220
            + E    H +   GH +++ GGY    DN++     +  N+ ++   ++S L  + L   ME  G  P     + G   C +G R+Y+FGGY    +   N LY++ +       G    +K+               +DG         P+ RDK S   +++ +I FGGYG     SE+Q+  D  H+   +   +       GW+N + +F   T  W+ P   G +P  PRAAHS A+  +K ++FGGR+         R N+ +YL+L T+ W+     +  S   RSW TLT + D+  F+ GG + DN+PLSD +I  I
Sbjct:    9 VAEERSGHCAVVDGHFLYVWGGYVSIEDNEV-----YLPNDEMWTYDIDSGLWKMHL---ME--GELPPSMSGSCG--ACIHG-RLYVFGGYD--DKGYSNRLYFVNLRTR---DGTYTWEKITK-------------FDGQP-------PTPRDKLSCWVYKDRLIYFGGYGYR-RHSELQECFDV-HDASWEEQIFW------GWHNDVHVFDTKTRTWSQPEIKGGVPPQPRAAHSCAVLGNKGYVFGGRV------LQTRMNDLHYLNLDTWVWSGRISVNGESPKHRSWHTLTAITDDKLFLFGGLNADNIPLSDGWIHNI 282          
BLAST of F-box only protein 42 vs. Ensembl Mouse
Match: Fbxo42 (F-box protein 42 [Source:MGI Symbol;Acc:MGI:1924992])

HSP 1 Score: 65.855 bits (159), Expect = 1.223e-10
Identity = 63/260 (24.23%), Postives = 108/260 (41.54%), Query Frame = 3
Query:  474 MACCSNGN-----RIYLFGGYSLTKQEVVNALYYIEISKSIDFTGLLNIKKLCNKKPKAVLKFLSGSYDGDSEEIHRNFPSYRDKASIVYWRNNIIVFGGY--GSNFIRSEIQDNIDQGHNFLADNGEYVSGSGNRGWNNQLLIFSMSTNRWTNPATFGCIPCPRAAHSSAITDSKLFIFGGRLGMKNTAATVRSNEFYYLDLITFYWTKINLSDSASIIGRSWTTLTCVYDEVFFIVGGFSGDNVPLSDAYIVKIDNKP 1232
            M     GN     R Y + G  +T++   +A YY        F G    +  CN     + +    S +        ++PS +  A++V +++ +++FGG+   S +   + +   D+ H +          S ++ W N ++             T G  P P A HSS +   K+ +FGG LG +       SNE + LDL  + W+K N+S   S   R   +   + D    I+GG  G N    DA+++ +   P
Sbjct:   94 MKAVQEGNIQWESRTYPYPGTPITQRFSHSACYYDANQSMYVFGGC--TQSSCNAAFNDLWRLDLNSKEWIRPLASGSYPSPKAGATLVVYKDLLVLFGGWTRPSPYPLHQPERFFDEIHTY----------SPSKNWWNCIVT------------THG--PPPMAGHSSCVIGDKMIVFGGSLGSRQM-----SNEVWVLDLEQWAWSKPNIS-GPSPHPRGGQSQIVIDDTTLLILGGCGGPNALFKDAWLLHMHPGP 321          
BLAST of F-box only protein 42 vs. Ensembl Mouse
Match: Lztr1 (leucine-zipper-like transcriptional regulator, 1 [Source:MGI Symbol;Acc:MGI:1914113])

HSP 1 Score: 50.8322 bits (120), Expect = 1.253e-6
Identity = 44/176 (25.00%), Postives = 74/176 (42.05%), Query Frame = 3
Query:  705 RDKASIVYWRNNIIVFGGYGSNFIRSEIQDNIDQGHNFLADNGEYVSGSGNRGWNNQLLIFSMSTNRWTNPATFGCIPCPRAAHSSAITDSKLFIFGGRLGMKNTAATVRS-NEFYYLDLITFYWTKINLSDSASIIGRSWTTLTCVYDEVFFIVGGFSGDNVPLSDAYIVKIDNK 1229
            R K ++V +++ I VFGG              D G   L                N LL F +    W    T G  P PR  HS+ +  S +F+FGG  G   + + +++ N+ +     T  WT+  + +    + RS    T VY +  +I  G+ G N  L+D + + + ++
Sbjct:   65 RSKHTVVAYKDAIYVFGG--------------DNGKTML----------------NDLLRFDVKDCSWCRAFTTGTPPAPRYHHSAVVYGSSMFVFGGYTGDIYSNSNLKNKNDLFEYKFATGQWTEWKI-EGRLPVARSAHGAT-VYSDKLWIFAGYDG-NARLNDMWTIGLQDR 207          
BLAST of F-box only protein 42 vs. UniProt/SwissProt
Match: sp|Q4G5Y1|KLDC2_MOUSE (Kelch domain-containing protein 2 OS=Mus musculus OX=10090 GN=Klhdc2 PE=2 SV=3)

HSP 1 Score: 135.576 bits (340), Expect = 2.366e-33
Identity = 118/443 (26.64%), Postives = 185/443 (41.76%), Query Frame = 3
Query:  219 SFDSSKFSELIEPPM--AHVSASIGHNIFLIGGYRITFDNDLRTIIAF--DKNNLLYYNVLNSQLDTVELSYDMESVGSFPTEFFCASGMACCSNGNRIYLFGGYSLTKQEVVNALYYIEISKSIDFTGLLNIKKLCNKKPKAVLKFLSGSYDGDSEEIHRNFPSYRDKASIVYWRNNIIVFGGYGSNFIRSEIQDNIDQGHNFLADNGEYVSGSGNRGWNNQLLIFSMSTNRWTNPATFGCIPCPRAAHSSAITDSKLFIFGGRLGMKNTAATVRSNEFYYLDLITFYWTKINLSDSASIIGRSWTTLTCVYDEVFFIVGGFSGDNVPLSDAYIVKIDNKPNVGKVTAKLRCFQSANW----DPYIDRSSWNTSELFTPASRMWHSSCLAADGFIYIIGGCRND-LASXXXXXXXXXXXXXPEPLPLYRLCLWSVFLLKPNL 1520
            +F++ +  EL  P     HV+ S G ++F+ GGY+    N +R +  F   +  L  YN+   +   +    D+             SG         +YLFGG+    +   N  Y ++ S+S D  GL   +  C   P                      PS +DK  +  ++N +I FGGYG       + ++   G  F  D   + + S  RGWN+ + I    T  W+ P T G  P PRAAH+ A   +K F+FGGR          R N+ +YL+L T+ W ++ +      +GRSW +LT V  +  F+ GGF+ +  PLSDA+                  C     W     PY+++             R+WH++C + +G + + GGC N+ L          +     +P  L RL L +V   K  L
Sbjct:   17 AFENYEAMELACPAERSGHVAVSDGRHMFVWGGYK---SNQVRGLYDFYLPREELWIYNMETGRWKKINTEGDVPP---------SMSGSCAVCVDRVLYLFGGHH--SRGNTNKFYMLD-SRSAD-RGLQWERIDCQGIP----------------------PSSKDKLGVWVYKNKLIFFGGYGY------LPEDKVLG-TFEFDETSFWNSSHPRGWNDHVHILDTETFAWSQPITTGKAPSPRAAHACATVGNKGFVFGGRY------RDARMNDLHYLNLDTWEWNEL-IPQGVCPVGRSWHSLTPVSSDHLFLFGGFTTEKQPLSDAWTY----------------CISKNEWIQFNHPYVEK------------PRLWHTACASDEGEVIVFGGCANNLLVHHRAAHSNEVLIFSVQPKSLVRLSLEAVICFKEML 379          
BLAST of F-box only protein 42 vs. UniProt/SwissProt
Match: sp|Q9Y2U9|KLDC2_HUMAN (Kelch domain-containing protein 2 OS=Homo sapiens OX=9606 GN=KLHDC2 PE=1 SV=1)

HSP 1 Score: 135.576 bits (340), Expect = 2.984e-33
Identity = 118/440 (26.82%), Postives = 186/440 (42.27%), Query Frame = 3
Query:  219 SFDSSKFSELIEPPM--AHVSASIGHNIFLIGGYRITFDNDLRTIIAF--DKNNLLYYNVLNSQLDTVELSYDMESVGSFPTEFFCASGMACCSNGNRIYLFGGYSLTKQEVVNALYYIEISKSIDFTGLLNIKKL-CNKKPKAVLKFLSGSYDGDSEEIHRNFPSYRDKASIVYWRNNIIVFGGYGSNFIRSEIQDNIDQGHNFLADNGEYVSGSGNRGWNNQLLIFSMSTNRWTNPATFGCIPCPRAAHSSAITDSKLFIFGGRLGMKNTAATVRSNEFYYLDLITFYWTKINLSDSASIIGRSWTTLTCVYDEVFFIVGGFSGDNVPLSDAYIVKIDNKPNVGKVTAKLRCFQSANWDPYIDRSSWNTSELFTPASRMWHSSCLAADGFIYIIGGCRND-LASXXXXXXXXXXXXXPEPLPLYRLCLWSVFLLKPNL 1520
            +F+S +  EL  P     HV+ S G ++F+ GGY+    N +R +  F   +  L  YN+   +   +    D+             SG         +YLFGG+    +   N  Y ++ S+S D   +L  +++ C   P                      PS +DK  +  ++N +I FGGYG       + ++   G  F  D   + + S  RGWN+ + I    T  W+ P T G  P PRAAH+ A   ++ F+FGGR          R N+ +YL+L T+ W ++ +      +GRSW +LT V  +  F+ GGF+ D  PLSDA+                  C     W  +        +  +T   R+WH++C + +G + + GGC N+ L          I     +P  L RL L +V   K  L
Sbjct:   17 AFESYESMELACPAERSGHVAVSDGRHMFVWGGYK---SNQVRGLYDFYLPREELWIYNMETGRWKKINTEGDVPP---------SMSGSCAVCVDRVLYLFGGHH--SRGNTNKFYMLD-SRSTD--RVLQWERIDCQGIP----------------------PSSKDKLGVWVYKNKLIFFGGYGY------LPEDKVLG-TFEFDETSFWNSSHPRGWNDHVHILDTETFTWSQPITTGKAPSPRAAHACATVGNRGFVFGGRY------RDARMNDLHYLNLDTWEWNEL-IPQGICPVGRSWHSLTPVSSDHLFLFGGFTTDKQPLSDAWTY----------------CISKNEWIQF--------NHPYTEKPRLWHTACASDEGEVIVFGGCANNLLVHHRAAHSNEILIFSVQPKSLVRLSLEAVICFKEML 379          
BLAST of F-box only protein 42 vs. UniProt/SwissProt
Match: sp|Q3KRE6|KLDC2_RAT (Kelch domain-containing protein 2 OS=Rattus norvegicus OX=10116 GN=Klhdc2 PE=2 SV=1)

HSP 1 Score: 133.65 bits (335), Expect = 1.411e-32
Identity = 117/444 (26.35%), Postives = 186/444 (41.89%), Query Frame = 3
Query:  219 SFDSSKFSELIEPPM--AHVSASIGHNIFLIGGYRITFDNDLRTIIAF--DKNNLLYYNVLNSQLDTVELSYDMESVGSFPTEFFCASGMACCSNGNRIYLFGGYSLTKQEVVNALYYIEISKSIDFTGLLNIKKL-CNKKPKAVLKFLSGSYDGDSEEIHRNFPSYRDKASIVYWRNNIIVFGGYGSNFIRSEIQDNIDQGHNFLADNGEYVSGSGNRGWNNQLLIFSMSTNRWTNPATFGCIPCPRAAHSSAITDSKLFIFGGRLGMKNTAATVRSNEFYYLDLITFYWTKINLSDSASIIGRSWTTLTCVYDEVFFIVGGFSGDNVPLSDAYIVKIDNKPNVGKVTAKLRCFQSANW----DPYIDRSSWNTSELFTPASRMWHSSCLAADGFIYIIGGCRND-LASXXXXXXXXXXXXXPEPLPLYRLCLWSVFLLKPNL 1520
            +F+  +  EL  P     HV+ S G ++F+ GGY+    N +R +  F   +  L  YN+   +   +    D+             SG         +YLFGG+    +   N  Y ++ S+S D   +L  +++ C   P                      PS +DK  +  ++N +I FGGYG       + ++   G  F  D   + + S  RGWN+ + I    T  W+ P T G  P PRAAH+ A   +K F+FGGR          R N+ +YL+L T+ W ++ +      +GRSW +LT V  +  F+ GGF+ +  PLSDA+                  C     W     PY+++             R+WH++C + +G + + GGC N+ L          +     +P  L RL L +V   K  L
Sbjct:   17 AFEGYEAMELACPAERSGHVAVSDGRHMFVWGGYK---SNQVRGLYDFYLPREELWIYNMETGRWKKINTEGDVPP---------SMSGSCAVCVDRVLYLFGGHH--SRGNTNKFYMLD-SRSAD--RVLQWERIDCQGIP----------------------PSSKDKLGVWVYKNKLIFFGGYGY------LPEDKVLG-TFEFDETSFWNSSHPRGWNDHVHILDTETFAWSQPITTGKAPSPRAAHACATVGNKGFVFGGRY------RDARMNDLHYLNLDTWEWNEL-IPQGICPVGRSWHSLTPVSSDHLFLFGGFTTEKQPLSDAWTY----------------CISKNEWIQFNHPYVEK------------PRLWHTACASDEGEVIVFGGCANNLLVHHRAAHSNEVLIFSVQPKSLVRLSLEAVICFKEML 379          
BLAST of F-box only protein 42 vs. UniProt/SwissProt
Match: sp|Q5E9A7|KLDC2_BOVIN (Kelch domain-containing protein 2 OS=Bos taurus OX=9913 GN=KLHDC2 PE=2 SV=1)

HSP 1 Score: 132.88 bits (333), Expect = 2.516e-32
Identity = 117/440 (26.59%), Postives = 186/440 (42.27%), Query Frame = 3
Query:  219 SFDSSKFSELIEPPM--AHVSASIGHNIFLIGGYRITFDNDLRTIIAF--DKNNLLYYNVLNSQLDTVELSYDMESVGSFPTEFFCASGMACCSNGNRIYLFGGYSLTKQEVVNALYYIEISKSIDFTGLLNIKKL-CNKKPKAVLKFLSGSYDGDSEEIHRNFPSYRDKASIVYWRNNIIVFGGYGSNFIRSEIQDNIDQGHNFLADNGEYVSGSGNRGWNNQLLIFSMSTNRWTNPATFGCIPCPRAAHSSAITDSKLFIFGGRLGMKNTAATVRSNEFYYLDLITFYWTKINLSDSASIIGRSWTTLTCVYDEVFFIVGGFSGDNVPLSDAYIVKIDNKPNVGKVTAKLRCFQSANWDPYIDRSSWNTSELFTPASRMWHSSCLAADGFIYIIGGCRND-LASXXXXXXXXXXXXXPEPLPLYRLCLWSVFLLKPNL 1520
            +++  + +EL  P     HV+ S G ++F+ GGY+    N +R +  F   +  L  YN+   +   +    D+             SG         +YLFGG+    +   N  Y ++ S+S D   +L+ +++ C   P                      PS +DK  +  ++N +I FGGYG       + ++   G  F  D   + + S  RGWN+ + I    T  W+ P T G  P PRAAH+ A   +K F+FGGR          R N+ +YL+L T+ W ++ +      +GRSW +LT V  +  F+ GGF+ D  PLSDA+                  C     W  +        +   T   R+WH++C + +G + + GGC N+ L          I     +P  L RL L +V   K  L
Sbjct:   17 AYEGYESAELACPAERSGHVAVSDGRHMFVWGGYK---SNQVRGLYDFYLPREELWIYNMETGRWKKINTEGDVPP---------SMSGSCAVCVDRVLYLFGGHH--SRGNTNKFYMLD-SRSTD--RVLHWERIDCQGVP----------------------PSSKDKLGVWVYKNKLIFFGGYGY------LPEDKVLG-TFEFDETSFWNSSHPRGWNDHVHILDTETFIWSQPITTGKPPSPRAAHACATVGNKGFVFGGRY------RDARMNDLHYLNLDTWEWNEL-IPQGICPVGRSWHSLTPVSSDHLFLFGGFTTDKQPLSDAWTY----------------CISKNEWIKF--------NHPHTEKPRLWHTACASDEGEVIVFGGCANNLLVHHRAAHSNEILIFSVQPKSLVRLSLEAVICFKEML 379          
BLAST of F-box only protein 42 vs. UniProt/SwissProt
Match: sp|Q80YG3|KLDC1_MOUSE (Kelch domain-containing protein 1 OS=Mus musculus OX=10090 GN=Klhdc1 PE=2 SV=1)

HSP 1 Score: 132.88 bits (333), Expect = 2.590e-32
Identity = 119/445 (26.74%), Postives = 195/445 (43.82%), Query Frame = 3
Query:  246 LIEPPMAHVSASIGHNIFLIGGYRITFDNDLRTIIAFDKNNLLYYNVLNSQLDTVELSYDMESVGSFPTEFFCASGMACCSNGNRIYLFGGYSLTKQEVVNALYYIEISKSIDFTGLLNIKKLCNKKPKAVLKFLSGSYDGDSEEIHRNFPSYRDKASIVYWRNNIIVFGGYGSNFIRSEIQDNIDQGHNFLADNGEYVSGSGNRGWNNQLLIFSMSTNRWTNPATFGCIP-CPRAAHSSAITDSKLFIFGGRLGMKNTAATVRSNEFYYLDLITFYWTKINLSDSASIIGRSWTTLTCVYDEVFFIVGGFSGDNVPLSDAYIVKIDNKPNVGKVTAKLRCFQSANWDPYIDRSSWNTSELFTPASRMWHSSCLAADGFIYIIGGCRNDLASXXXXXXXXXXXXXPEPLPLYRLCLWSV----FLLKPNLNEHEIPQKLFNDLLS 1565
            + E    H +   GH +++ GGY    DN++     +  N+ ++   ++S L  + L   ME  G  P     + G   C +G R+Y+FGGY    +   N LY++ +       G    +K+               +DG         P+ RDK S   +++ +I FGGYG     SE+Q+  D  H+   +   +       GW+N + +F   T  W+ P   G +P  PRAAHS A+  +K ++FGGR+         R N+ +YL+L T+ W+     +  S   RSW TLT + D+  F+ GG + DN+PLSD +I  I              C++     PY                R+WH++CL  +  I + GG +++L          +   + +P  L R CL  +     +LK  ++   +P KL   +L 
Sbjct:    9 VAEERSGHCAVVDGHFLYVWGGYVSIEDNEV-----YLPNDEMWTYDIDSGLWKMHL---ME--GELPPSMSGSCG--ACIHG-RLYVFGGYD--DKGYSNRLYFVNLRTR---DGTYTWEKIT-------------KFDGQP-------PTPRDKLSCWVYKDRLIYFGGYGYRR-HSELQECFDV-HDASWEEQIFW------GWHNDVHVFDTKTRTWSQPEIKGGVPPQPRAAHSCAVLGNKGYVFGGRV------LQTRMNDLHYLNLDTWVWSGRISVNGESPKHRSWHTLTAITDDKLFLFGGLNADNIPLSDGWIHNITTN-----------CWKQLRHLPYT-------------RPRLWHTACLGKENEIMVFGGSKDNLLFLDTGHCNDLLIFQTQPYSLLRSCLDCIGKNAIILKSQIS--LLPPKLLQQVLK 375          
BLAST of F-box only protein 42 vs. TrEMBL
Match: T1E663 (Kelch domain-containing protein 2-like protein OS=Crotalus horridus OX=35024 PE=2 SV=1)

HSP 1 Score: 143.28 bits (360), Expect = 1.432e-33
Identity = 122/443 (27.54%), Postives = 185/443 (41.76%), Query Frame = 3
Query:  255 PPM--AHVSASIGHNIFLIGGYRITFDNDLRTIIAF--DKNNLLYYNVLNSQLDTVELSYDMESVGSFPTEFFCASGMACCSNGNRIYLFGGYSLTKQEVVNALYYIEISKSIDFTGLLN-IKKLCNKKPKAVLKFLSGSYDGDSEEIHRNFPSYRDKASIVYWRNNIIVFGGYGSNFIRSEIQDNIDQGHNFLADNGEYVSGSGNRGWNNQLLIFSMSTNRWTNPATFGCIPCPRAAHSSAITDSKLFIFGGRLGMKNTAATVRSNEFYYLDLITFYWTKINLSDSASIIGRSWTTLTCVYDEVFFIVGGFSGDNVPLSDAYIVKIDNKPNVGKVTAKLRCFQSANWDPYIDRSSWNTSELFTPASRMWHSSCLAADGFIYIIGGC-RNDLASXXXXXXXXXXXXXPEPLPLYRLCLWSVFLLKPNLNE--HEIPQKLFNDL 1559
            PP    HV+ + G  +F+ GGY+   +  +R I  F   ++ +  YN+   Q           + G  P      SG         +YLFGG+        N  Y +  S+S D  G+L  ++  C   P                      PS +DK  +  +RN +I FGGYG          +++Q   F  D   + +    RGWNN + +    T  W+ P T G  P PRAAH+ A   ++ ++FGGR          R N+ Y+L+L T+ W +I +  S   +GRSW +LT +  +  F+ GGF+ D  PLSDA+I                 C     W  +           +    R+WH++C + +G + + GGC  N LA         I     +P  L RLCL +V   K  L    H +P+ L + L
Sbjct:   29 PPERSGHVAVTDGKCMFIWGGYK---NAQVRGIYDFYLPRDEIWIYNMETEQWTK------HRTTGDVPPSM---SGSCAVCVDKVLYLFGGHHDCGN--TNKFYMLN-SRSND--GVLQWVRVDCQGIP----------------------PSSKDKLGVWVYRNKLIFFGGYG-------YYPDVEQIGTFEFDETSFWNSGLPRGWNNHVHVLDTETFTWSQPVTTGKSPSPRAAHACATVGNRGYVFGGRY------RESRMNDLYFLNLETWEWQQIVVQGSCP-VGRSWHSLTTISSDHLFLFGGFTTDKQPLSDAWIY----------------CISKNEWIQF--------EHNYLEKPRLWHTACASDEGEVIVFGGCASNLLAHHKAAHSNEILVFSLQPKSLARLCLEAVMCFKETLASSWHCLPKHLLHRL 394          
BLAST of F-box only protein 42 vs. TrEMBL
Match: A0A0K8S089 (Kelch domain-containing protein 2-like protein OS=Crotalus horridus OX=35024 PE=4 SV=1)

HSP 1 Score: 143.28 bits (360), Expect = 1.742e-33
Identity = 122/443 (27.54%), Postives = 185/443 (41.76%), Query Frame = 3
Query:  255 PPM--AHVSASIGHNIFLIGGYRITFDNDLRTIIAF--DKNNLLYYNVLNSQLDTVELSYDMESVGSFPTEFFCASGMACCSNGNRIYLFGGYSLTKQEVVNALYYIEISKSIDFTGLLN-IKKLCNKKPKAVLKFLSGSYDGDSEEIHRNFPSYRDKASIVYWRNNIIVFGGYGSNFIRSEIQDNIDQGHNFLADNGEYVSGSGNRGWNNQLLIFSMSTNRWTNPATFGCIPCPRAAHSSAITDSKLFIFGGRLGMKNTAATVRSNEFYYLDLITFYWTKINLSDSASIIGRSWTTLTCVYDEVFFIVGGFSGDNVPLSDAYIVKIDNKPNVGKVTAKLRCFQSANWDPYIDRSSWNTSELFTPASRMWHSSCLAADGFIYIIGGC-RNDLASXXXXXXXXXXXXXPEPLPLYRLCLWSVFLLKPNLNE--HEIPQKLFNDL 1559
            PP    HV+ + G  +F+ GGY+   +  +R I  F   ++ +  YN+   Q           + G  P      SG         +YLFGG+        N  Y +  S+S D  G+L  ++  C   P                      PS +DK  +  +RN +I FGGYG          +++Q   F  D   + +    RGWNN + +    T  W+ P T G  P PRAAH+ A   ++ ++FGGR          R N+ Y+L+L T+ W +I +  S   +GRSW +LT +  +  F+ GGF+ D  PLSDA+I                 C     W  +           +    R+WH++C + +G + + GGC  N LA         I     +P  L RLCL +V   K  L    H +P+ L + L
Sbjct:   29 PPERSGHVAVTDGKCMFIWGGYK---NAQVRGIYDFYLPRDEIWIYNMETEQWTK------HRTTGDVPPSM---SGSCAVCVDKVLYLFGGHHDCGN--TNKFYMLN-SRSND--GVLQWVRVDCQGIP----------------------PSSKDKLGVWVYRNKLIFFGGYG-------YYPDVEQIGTFEFDETSFWNSGLPRGWNNHVHVLDTETFTWSQPVTTGKSPSPRAAHACATVGNRGYVFGGRY------RESRMNDLYFLNLETWEWQQIVVQGSCP-VGRSWHSLTTISSDHLFLFGGFTTDKQPLSDAWIY----------------CISKNEWIQF--------EHNYLEKPRLWHTACASDEGEVIVFGGCASNLLAHHKAAHSNEILVFSLQPKSLARLCLEAVMCFKETLASSWHCLPKHLLHRL 394          
BLAST of F-box only protein 42 vs. TrEMBL
Match: A0A5G3IXI4 (Polymerase (RNA) II (DNA directed) polypeptide B, 140kDa OS=Xenopus tropicalis OX=8364 GN=polr2b PE=4 SV=1)

HSP 1 Score: 143.28 bits (360), Expect = 1.822e-33
Identity = 113/423 (26.71%), Postives = 186/423 (43.97%), Query Frame = 3
Query:  264 AHVSASIGHNIFLIGGYRITFDNDLRTIIAF--DKNNLLYYNVLNSQLDTVELSYDMESVGSFPTEFFCASGMACCSNGNRIYLFGGYSLTKQEVVNALYYIEISKSIDFTGLLNIKKL-CNKKPKAVLKFLSGSYDGDSEEIHRNFPSYRDKASIVYWRNNIIVFGGYGSNFIRSEIQDNIDQGHNFLADNGEYVSGSGNRGWNNQLLIFSMSTNRWTNPATFGCIPCPRAAHSSAITDSKLFIFGGRLGMKNTAATVRSNEFYYLDLITFYWTKINLSDSASIIGRSWTTLTCVYDEVFFIVGGFSGDNVPLSDAYIVKIDNKPNVGKVTAKLRCFQSANWDPYIDRSSWNTSELFTPASRMWHSSCLAADGFIYIIGGCRNDLASXXXXXXXXXXXXXP-EPLPLYRLCLWSVFLLKPNL 1520
             HV+ + G +IF+ GGY+   +  +R    F   ++ +  Y++ N     V+      + G  P      SG         +YLFGG+        N  Y + ++      G L  +K+ C   P                      PS +DK  +  ++N ++ FGGYG        Q++I     F  D   + +    RGWNN + + ++    W  P T G  P PRAAHS A  +++ ++FGGR          R N+ YYL+  T+ W ++ ++   + +GRSW +LT    +  F+ GGF+ D  PLSDA+I ++                 +  W P+++  S           R+WH++C + +G I++ GGC N+L +      +    + P +P  L RLCL +V L K  L
Sbjct:   37 GHVAVTDGQSIFVWGGYK---NAPVRGFYDFYLPRDEIWIYDMENGSWQRVK------TKGEIP---LSMSGSCAACVDKVLYLFGGHHAHGN--TNMFYMLNLNPR---DGDLFWEKVDCKGIP----------------------PSPKDKLGVWTYKNKLVYFGGYGY------YQEDIVGTFEF--DETSFGNVGLPRGWNNHVHVLNLDNFTWERPVTTGKSPSPRAAHSCATVENRGYVFGGRY------RDSRMNDMYYLNFSTWEWHEV-ITQGGNPVGRSWHSLTQASSDSLFLFGGFTTDKQPLSDAWIYRL----------------STNEWIPFMNHHS--------EKPRLWHTACGSKEGEIFVFGGCANNLLAHHRAAHSNEVLVFPVQPKSLVRLCLETVILFKEML 381          
BLAST of F-box only protein 42 vs. TrEMBL
Match: A0A0L8GWH4 (Uncharacterized protein OS=Octopus bimaculoides OX=37653 GN=OCBIM_22026537mg PE=4 SV=1)

HSP 1 Score: 142.51 bits (358), Expect = 2.402e-33
Identity = 118/396 (29.80%), Postives = 168/396 (42.42%), Query Frame = 3
Query:  228 SSKFSELIEPPMAHVSASIGHNIFLIGGYRITFDNDLRTIIAFDKNNLLYYNVLNSQLDTVELSYDMESVGSFPTEFFCASGMACCSNGNRIYLFGGYSLTKQEVVNALYYIEISKSIDFTGLLNIKKLCNKKPKAVLKFLSGSYDGDSEEIHRNFPSYRDKASIVYWRNNIIVFGGYGSNFIRSEIQDNIDQGHNFLADNGEYVSG-----SGNRGWNNQLLIFSMSTNRWTNPATFGCIPCPRAAHSSAITDSKLFIFGGRLGMKNTAATVRSNEFYYLDLITFYWTKINLSDSASIIGRSWTTLTCVYDEVFFIVGGFSGDNVPLSDAYIVKIDNKPNVGKVTAKLRCFQSANWDPYIDRSSWNTSELFTPASRMWHSSCLAADGFIYIIGGC 1400
            + K+ E I     H+ A  G+ + + GGY +   N  R          +Y  +LN         Y  E+    P      SG       +++Y+ GG+  TKQ   N++Y             LNIK +  KK       L  +Y+G         PS RDK S   ++N +  FGG+G +              +FL D+GEYV       S  RGWNNQLLIF    + W+NP   G +P PRAAH+S    +K ++FGGR        + R N+ Y LDL T +WTK  ++      GRSW + T V      + GGF+ DN PL+D ++  +                            SW   E+     R+WHS C+  D  + I GGC
Sbjct:    6 TGKYQE-ISARAGHLVACFGNFMCVWGGYEVREYN--REKYCKSNEIWMYDTILNRW-------YSYETKCEIP---LARSGSIAQLIDDKLYVHGGH--TKQGNTNSIY------------CLNIKTMEWKK-------LLSNYEGP-------LPSPRDKHSSWVYKNKLYCFGGHGPDIT------------DFLCDSGEYVEDVSSDMSYPRGWNNQLLIFDCDRHCWSNPKCTGEVPSPRAAHASTRIGNKTYVFGGR------HLSNRMNDLYCLDLDTLHWTKPQITGHVP-CGRSWCSFTAVSPTRILLCGGFTQDNQPLADIWLFDVTT-------------------------FSWIIYEMSFSIPRLWHSCCVTPDDDVIIFGGC 316          
BLAST of F-box only protein 42 vs. TrEMBL
Match: A0A1L8F9S0 (Uncharacterized protein OS=Xenopus laevis OX=8355 GN=XELAEV_18039626mg PE=1 SV=1)

HSP 1 Score: 142.51 bits (358), Expect = 3.375e-33
Identity = 114/423 (26.95%), Postives = 184/423 (43.50%), Query Frame = 3
Query:  264 AHVSASIGHNIFLIGGYRITFDNDLRTIIAF--DKNNLLYYNVLNSQLDTVELSYDMESVGSFPTEFFCASGMACCSNGNRIYLFGGYSLTKQEVVNALYYIEISKSIDFTGLLNIKKL-CNKKPKAVLKFLSGSYDGDSEEIHRNFPSYRDKASIVYWRNNIIVFGGYGSNFIRSEIQDNIDQGHNFLADNGEYVSGSGNRGWNNQLLIFSMSTNRWTNPATFGCIPCPRAAHSSAITDSKLFIFGGRLGMKNTAATVRSNEFYYLDLITFYWTKINLSDSASIIGRSWTTLTCVYDEVFFIVGGFSGDNVPLSDAYIVKIDNKPNVGKVTAKLRCFQSANWDPYIDRSSWNTSELFTPASRMWHSSCLAADGFIYIIGGCRNDLASXXXXXXXXXXXXXP-EPLPLYRLCLWSVFLLKPNL 1520
             HV+ + G  IF+ GGY+   +  +R    F   ++ +  Y++ N     V+      + G  P      SG         +YLFGG+        N  Y + ++      G L  +K+ C   P                      PS +DK  +  ++N ++ FGGYG        Q+  D    F  D   + +    RGWNN + + ++    W  P T G  P PRAAH+ A   ++ ++FGGR          R N+ YYL+  T+ W ++ ++   +  GRSW +LT    +  F+ GGF+ D  PLSDA+I ++                 +  W P+++    N SE      R+WH++C + +G I++ GGC N+L +      +    + P +P  L RLCL +V L K  L
Sbjct:   36 GHVAVTDGQRIFVWGGYK---NAPVRGFYDFYLPRDEIWIYDMENGNWQRVK------TKGEIP---LSMSGSCAACVDKVLYLFGGHHAHGN--TNMFYMLNLNPR---DGDLFWEKVDCKGIP----------------------PSPKDKLGVWTYKNKLVYFGGYGY------YQE--DTAGTFEFDETSFGNAGLPRGWNNHVHVLNLDNFTWERPVTTGKSPSPRAAHACATVGNRGYVFGGRY------RDSRMNDLYYLNFSTWEWHEV-ITQGGNPTGRSWHSLTQASSDSLFLFGGFTTDKQPLSDAWIYRL----------------STNEWIPFMN----NHSE----KPRLWHTACASKEGEIFVFGGCANNLLAHHRAAHSNEVLVFPVQPKSLVRLCLETVILFKEML 380          
BLAST of F-box only protein 42 vs. Ensembl Cavefish
Match: klhdc2 (kelch domain containing 2 [Source:ZFIN;Acc:ZDB-GENE-070410-69])

HSP 1 Score: 121.709 bits (304), Expect = 1.529e-29
Identity = 101/388 (26.03%), Postives = 169/388 (43.56%), Query Frame = 3
Query:  264 AHVSASIGHNIFLIGGYRITFDNDLRTIIAFDKNNLLYYNVLNSQLDTVELSYDMESVGSFPTEFFCASGMACCSNGNRIYLFGGYSLTKQEVVNALYYIEI-SKSIDFTGLLNIKKLCNKKPKAVLKFLSGSYDGDSEEIHRNFPSYRDKASIVYWRNNIIVFGGYGSNFIRSEIQDNIDQGH--NFLADNGEYVSGSGNRGWNNQLLIFSMSTNRWTNPATFGCIPCPRAAHSSAITDSKLFIFGGRLGMKNTAATVRSNEFYYLDLITFYWTKINLSDSASIIGRSWTTLTCVYDEVFFIVGGFSGDNVPLSDAYIVKIDNKPNVGKVTAKLRCFQSANWDPYIDRSSWNTSELFTPASRMWHSSCLAADGFIYIIGGCRNDLAS 1418
             HV+    + +++ GGY++T      T  AF    L    V    ++T      + S G  P     + G+  C +G  +Y+FGG+        N +Y + + S S+ +  + ++K L                           P+ +DK     ++N ++ FGGYG              GH   F  D    +     RGWNN + I ++ T+ W+ PAT G  P PRAAH+ A   ++ F+FGGR          R N+ Y +++ ++ W+++++      +GRSW +   V ++  F+ GGF+ +   LSDA+                L C  +  W P+      N  E    + R+WH++C   DG I++ GGC N+L S
Sbjct:   68 GHVAVVDRNCMYVWGGYKVT------TATAFVDLYLPKKEVWIYNMETGRWRMQL-SKGELPAAMSGSCGV--CIDG-ILYVFGGHYARGN--TNLVYRLPLRSSSLVWERMKDLKGLA--------------------------PTCKDKLGCWVYKNRLVYFGGYGHV---------AQAGHLGAFELDENSLMGNHAARGWNNHIHILNLETSTWSQPATKGNAPTPRAAHACATIGNRGFVFGGRY------MDHRLNDLYCINMDSWEWSEMSVPQQGP-VGRSWHSFIPVSNDHIFLFGGFTTNRETLSDAW----------------LYCVSTNEWRPFKH----NHEE----SPRLWHTACSNPDGEIFVFGGCANNLLS 377          
BLAST of F-box only protein 42 vs. Ensembl Cavefish
Match: ENSAMXT00000006485.2 (kelch domain-containing protein 1-like [Source:NCBI gene;Acc:103022594])

HSP 1 Score: 71.633 bits (174), Expect = 6.271e-13
Identity = 46/175 (26.29%), Postives = 78/175 (44.57%), Query Frame = 3
Query:  696 PSYRDKASIVYWRNNIIVFGGYGSNFIRSEIQDNIDQGHNFLADNGEYVSGSGN----RGWNNQLLIFSMSTNRWTNPATFGCIPCPRAAHSSAITDSKLFIFGGRLGMKNTAATVRSNEFYYLDLITFYWTKINLSDSASIIGRSWTTLTCVYDEVFFIVGGFSGDNVPLSDAY 1208
            PS RD+ S   +++ +I FGGY    +R      +    +F  D   +           GWNN++ +F   +  WT P T G  P PR +H++A   +K ++ GG            + + + LDL+T+ W+++    +    GR   +LT       F+ GG S     L+D +
Sbjct:  112 PSPRDRHSCWVFKDRLIYFGGYSCKSVR-----EVSNFKSFTVDETSWAMIGSEFFRFWGWNNEVHMFEPGSATWTEPHTQGQPPEPRCSHANATLGTKGYVCGG--------LETETIDIHCLDLLTWTWSQMEPVATPVPKGRILHSLTPTSHNTLFLFGGLSTSGQVLNDGW 273          
BLAST of F-box only protein 42 vs. Ensembl Cavefish
Match: fbxo42 (F-box protein 42 [Source:NCBI gene;Acc:103041203])

HSP 1 Score: 63.929 bits (154), Expect = 3.240e-10
Identity = 57/244 (23.36%), Postives = 107/244 (43.85%), Query Frame = 3
Query:  495 NRIYLFGGYSLTKQEVVNALYYIEISKSIDFTGLLNIKKLCNKKPKAVLKFLSGSYDGDSEEIHRNFPSYRDKASIVYWRNNIIVFGGY--GSNFIRSEIQDNIDQGHNFLADNGEYVSGSGNRGWNNQLLIFSMSTNRWTNPATFGCIPCPRAAHSSAITDSKLFIFGGRLGMKNTAATVRSNEFYYLDLITFYWTKINLSDSASIIGRSWTTLTCVYDEVFFIVGGFSGDNVPLSDAYIVKI 1220
            +R Y + G  +T++   +A YY        F G    +  CN     + +    S +        ++PS +  A++V +++ +++FGG+   S +   + +   D+ H +          S ++ W N ++             T G  P P A HSS++ ++ + +FGG LG +       SNE + LDL  + W+K  +    S   R   +   + D+   I+GG  G N  L DA+++ +
Sbjct:  119 SRTYPYPGTPITQRFSHSACYYDSNQSMYVFGGC--TQSSCNAAFNDLWRLDLNSKEWIRPLASGSYPSPKAGATLVMYKDLLVLFGGWTRPSPYPLHQPERFFDEIHTY----------SPSKNWWNCIVT------------THG--PPPMAGHSSSVINNNMIVFGGSLGARQM-----SNEVWVLDLEQWSWSKPTI-KGPSPHPRGGQSQIVIDDDTLLILGGCGGPNALLKDAWLLHM 330          
BLAST of F-box only protein 42 vs. Ensembl Cavefish
Match: ENSAMXT00000020761.2 (pep primary_assembly:Astyanax_mexicanus-2.0:9:4299011:4307057:1 gene:ENSAMXG00000020153.2 transcript:ENSAMXT00000020761.2 gene_biotype:protein_coding transcript_biotype:protein_coding)

HSP 1 Score: 61.6178 bits (148), Expect = 3.557e-10
Identity = 68/244 (27.87%), Postives = 99/244 (40.57%), Query Frame = 3
Query:  468 SGMACCSNGNRIYLFGGYSLTKQEVVNALYYIEISKSIDFTGLLNIKKLCNKKPKAVLKFLSGSYDGDSEEIHRNF-PSYRDKASIVYWRNNIIVFGGYGSNFIRSEIQDNIDQGHNFLADNGEYVSGSGNRGWNNQLLIFSMSTNRWTNPATFGCIPCPRAAHSSAITDSKLFIFGGRLGMKNTAATVRSNEFYYLDLITFYWTKINLSDSASIIGRSWTTLTCVYDEVFFIVGGFSGDNVPL 1196
            SGM  C     +Y+FGG     Q   N  Y ++++                           G Y  +    H  F PS RDK S   +++ II FGGYG   +       I+    F+ D   +       GWNN++ +F   T  W  P T G  P PRAAH+SA  ++K ++ GGR                   ++ F    +++  +    GRSW TLT V +   F+ GG S D  P+
Sbjct:   54 SGMCGCVLKGHMYIFGGCGDDGQ--TNEHYLVDLN--------------------------DGRYFWEKIRHHSGFLPSPRDKFSCWVYKSRIIYFGGYGHKLL-----SEINNPRTFIVDEDIFW------GWNNEVHVFDSETKSWNCPTTSGRAPAPRAAHASATINNKGYVCGGR------------------KMVRF----LHVPRTTVPQGRSWHTLTAVSETSLFLYGGLSMDCRPM 236          
BLAST of F-box only protein 42 vs. Ensembl Cavefish
Match: fbxo42 (F-box protein 42 [Source:NCBI gene;Acc:103041203])

HSP 1 Score: 63.929 bits (154), Expect = 3.871e-10
Identity = 57/244 (23.36%), Postives = 107/244 (43.85%), Query Frame = 3
Query:  495 NRIYLFGGYSLTKQEVVNALYYIEISKSIDFTGLLNIKKLCNKKPKAVLKFLSGSYDGDSEEIHRNFPSYRDKASIVYWRNNIIVFGGY--GSNFIRSEIQDNIDQGHNFLADNGEYVSGSGNRGWNNQLLIFSMSTNRWTNPATFGCIPCPRAAHSSAITDSKLFIFGGRLGMKNTAATVRSNEFYYLDLITFYWTKINLSDSASIIGRSWTTLTCVYDEVFFIVGGFSGDNVPLSDAYIVKI 1220
            +R Y + G  +T++   +A YY        F G    +  CN     + +    S +        ++PS +  A++V +++ +++FGG+   S +   + +   D+ H +          S ++ W N ++             T G  P P A HSS++ ++ + +FGG LG +       SNE + LDL  + W+K  +    S   R   +   + D+   I+GG  G N  L DA+++ +
Sbjct:  119 SRTYPYPGTPITQRFSHSACYYDSNQSMYVFGGC--TQSSCNAAFNDLWRLDLNSKEWIRPLASGSYPSPKAGATLVMYKDLLVLFGGWTRPSPYPLHQPERFFDEIHTY----------SPSKNWWNCIVT------------THG--PPPMAGHSSSVINNNMIVFGGSLGARQM-----SNEVWVLDLEQWSWSKPTI-KGPSPHPRGGQSQIVIDDDTLLILGGCGGPNALLKDAWLLHM 330          
BLAST of F-box only protein 42 vs. Ensembl Sea Lamprey
Match: KLHDC2 (kelch domain containing 2 [Source:HGNC Symbol;Acc:HGNC:20231])

HSP 1 Score: 115.546 bits (288), Expect = 4.615e-28
Identity = 73/240 (30.42%), Postives = 108/240 (45.00%), Query Frame = 3
Query:  696 PSYRDKASIVYWRNNIIVFGGYGSNFIRSEIQDNIDQGHNFLADNGEYVSGSGNRGWNNQLLIFSMSTNRWTNPATFGCIPCPRAAHSSAITDSKLFIFGGR-LGMKNTAATVRSNEFYYLDLITFYWTKINLSDSASIIGRSWTTLTCVYDEVFFIVGGFSGDNVPLSDAYIVKIDNKPNVGKVTAKLRCFQSANWDPYIDRSSWNTSELFTPASRMWHSSCLAADGFIYIIGGCRNDL 1412
            PS +DK       N ++ FGGYG        Q        F  D       + +RGWNN + IF + T  W+ P T G  P PRAAH+ A   ++ ++FGGR LG        R N+ +YL+L  + W+          +GRSW TLT   D+  F+ GGF+ +  PL D +I  +                +S  W           S +     R+WH++ L+ +G + + GGC N+L
Sbjct:  133 PSPKDKLGCWTHGNKLVFFGGYG-------YQPREAHRGTFEFDETSLWGPNVSRGWNNHVHIFDLETYSWSQPLTTGTPPLPRAAHACATHGNRGYLFGGRYLG-------ARMNDLHYLNLDNWAWSGPIAVRGEVPVGRSWHTLTAASDDQLFLYGGFTTERQPLGDGWIYSV----------------KSLEWR--------KLSHIPPDRPRLWHTATLSEEGEVLVFGGCSNNL 334          
BLAST of F-box only protein 42 vs. Ensembl Sea Lamprey
Match: zgc:163014 (zgc:163014 [Source:ZFIN;Acc:ZDB-GENE-070424-100])

HSP 1 Score: 58.151 bits (139), Expect = 3.060e-9
Identity = 38/122 (31.15%), Postives = 57/122 (46.72%), Query Frame = 3
Query:  861 GWNNQLLIFSMSTNRWTNPATFGCIPCPRAAHSSAITDSKLFIFGGRLGMKNTAATVRSNEFYYLDLITFYWTKINLSDSASIIGRSWTTLTCVYDEVFFIVGGFSGDNVPLSDAYIVKIDN 1226
            G +NQL IF+   + W  P   G +PCPR+ HS  +  +KL IFGG        A +  ++ + LDL    +  + +   A    R W     V D    I GG++G    L+D +I  +D 
Sbjct:  315 GCSNQLYIFNPQHSIWYQPIVVGDLPCPRSGHSMILLKNKLVIFGG------WDAPMCFSDLHVLDLGFMEYAPVQV-QGAVPSPRCWHASAPVSDNRMIIHGGYNGQRA-LTDTHIFNVDT 428          
BLAST of F-box only protein 42 vs. Ensembl Sea Lamprey
Match: zgc:163014 (zgc:163014 [Source:ZFIN;Acc:ZDB-GENE-070424-100])

HSP 1 Score: 58.151 bits (139), Expect = 3.471e-9
Identity = 38/122 (31.15%), Postives = 57/122 (46.72%), Query Frame = 3
Query:  861 GWNNQLLIFSMSTNRWTNPATFGCIPCPRAAHSSAITDSKLFIFGGRLGMKNTAATVRSNEFYYLDLITFYWTKINLSDSASIIGRSWTTLTCVYDEVFFIVGGFSGDNVPLSDAYIVKIDN 1226
            G +NQL IF+   + W  P   G +PCPR+ HS  +  +KL IFGG        A +  ++ + LDL    +  + +   A    R W     V D    I GG++G    L+D +I  +D 
Sbjct:  307 GCSNQLYIFNPQHSIWYQPIVVGDLPCPRSGHSMILLKNKLVIFGG------WDAPMCFSDLHVLDLGFMEYAPVQV-QGAVPSPRCWHASAPVSDNRMIIHGGYNGQRA-LTDTHIFNVDT 420          
BLAST of F-box only protein 42 vs. Ensembl Sea Lamprey
Match: lztr1 (leucine-zipper-like transcription regulator 1 [Source:ZFIN;Acc:ZDB-GENE-030131-9564])

HSP 1 Score: 53.9138 bits (128), Expect = 8.009e-8
Identity = 46/176 (26.14%), Postives = 74/176 (42.05%), Query Frame = 3
Query:  705 RDKASIVYWRNNIIVFGGYGSNFIRSEIQDNIDQGHNFLADNGEYVSGSGNRGWNNQLLIFSMSTNRWTNPATFGCIPCPRAAHSSAITDSKLFIFGGRLGMKNTAATVR-SNEFYYLDLITFYWTKINLSDSASIIGRSWTTLTCVYDEVFFIVGGFSGDNVPLSDAYIVKIDNK 1229
            R K ++V +++ I VFGG              D G N L                N LL F +    W    T G  P PR  HS+ +  S +F+FGG  G   + + ++  N+ +     T  WT+  +      + RS    T VY++  +I  G+ G N  L+D + + + N+
Sbjct:    3 RSKHTVVAYKDAIYVFGG--------------DNGKNML----------------NDLLRFDVKDCSWGRAFTMGVPPAPRYHHSAVVHGSSMFVFGGYTGDIYSNSNLKNKNDMFEYKFATGQWTEWKVEGRLP-VARSAHGAT-VYEDKLWIFAGYDG-NARLNDMWTICLLNR 145          
BLAST of F-box only protein 42 vs. Ensembl Sea Lamprey
Match: ENSPMAT00000001771.1 (pep scaffold:Pmarinus_7.0:GL480830:19416:31634:1 gene:ENSPMAG00000001606.1 transcript:ENSPMAT00000001771.1 gene_biotype:protein_coding transcript_biotype:protein_coding)

HSP 1 Score: 48.1358 bits (113), Expect = 9.325e-7
Identity = 33/97 (34.02%), Postives = 45/97 (46.39%), Query Frame = 3
Query:  807 GHN-FLADNGEYVSGSGNR--GWNNQLLIFSMSTNRWTNPATFGCIPCPRAAHSSAITDSKLFIFGGRLGMKNTAATVRSNEFYYLDLITFYWTKIN 1088
            GH   L ++  YV G  N   G  N L  F + T+RW  P   G +P  R  HS+A     ++IFGG        A   SN+ + +D  T  WT I+
Sbjct:   74 GHTAVLVEDAIYVWGGRNDTDGACNVLYSFDIYTHRWVRPHVSGPVPGARDGHSAAALRKCMYIFGG----YEQLADCFSNDVHKMDTTTMTWTLIH 166          
BLAST of F-box only protein 42 vs. Ensembl Nematostella
Match: EDO49278 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7RH20])

HSP 1 Score: 97.8265 bits (242), Expect = 9.066e-22
Identity = 107/415 (25.78%), Postives = 174/415 (41.93%), Query Frame = 3
Query:  264 AHVSASIGHNIFLIGGYR-ITFDNDLRTIIAFDKNNLLYYNVLNSQLDT---VELSYDMESVGSFPTEFFCASGMACCSNGNRIYLFGGYSLTKQEVVNALYYIEISKSIDFTGLLNIKKLCNKKPKAVLKFLSGSYDGDSEEIHRNFPSYRDKASIVYWRNN--IIVFGGYGSNFIRSEIQDNIDQGHNFLADNGEYVSGSGNRGWNNQLLIFSMSTNRWTNPATFGCIPCPRAAHSSAITDSKLFIFGGRLGMKNTAATVRSNEFYYLDLITFYWTKINLSDSASIIGRSWTTLTCVYDEVFFIVGGFSGDNVPLSDAYIVKIDNKPNVGKVTAKLRCFQSANWDPYIDRSSWNTSELFTPASRMWHSSC-LAADGFIYIIGGCRNDLASXXXXXXXXXXXXXPEPLPLYRLC 1487
             H++     +I + GGY  I + +D   I+  D+  L  Y +    L+T    E   D+E +   P    CA    C   GN++YLFGG+  T     +A  ++           L++K         + + ++   +G+ +      PS RDK     W++N  I+ FGGYG     +    N  +   F+ +  + +     RGWNN + +      +W  P   G  P PRAA ++A   S+ ++FGGR          R N+ +YLDL  + W+    +      GR+W +LT V D+  F+ GG + ++  L DAYI+                  +S  W      +S  +S+      RMWH++C  +  G + I GG    +          +   R   LPL RL 
Sbjct:   18 GHIAVYYNGHILVWGGYHDIEWYHDEDDIVMVDRY-LSNYQLWLYNLETKSWCEKYGDLEDLIPPPLSGSCA---ICI--GNKMYLFGGH--TPSSGTSAEIFV-----------LDLKSY-------IWQRITDDLEGEIQ------PSPRDKFGC--WQHNDCIVYFGGYGVPPSLASRPPN--KAGEFIMNTVDRLPD--RRGWNNYVFMLDTEQMKWIIPEIKGDPPSPRAAFATAKIASRAYLFGGRF------MDTRLNDLHYLDLDKWQWSGSLTTAGCVPEGRTWHSLTAVSDKHLFLYGGLNNNSDALGDAYILDT----------------ESLVWSQIPTDASLPSSKTV----RMWHTACNTSTPGEVVIFGGSSKSILKYENPAIQEVIIFRFSALPLSRLA 368          
BLAST of F-box only protein 42 vs. Ensembl Nematostella
Match: EDO42623 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7S0Z0])

HSP 1 Score: 58.9214 bits (141), Expect = 1.777e-9
Identity = 57/253 (22.53%), Postives = 96/253 (37.94%), Query Frame = 3
Query:  477 ACCSNGNRIYLFGGYSLTKQEVVNALYYIEISKSIDFTGLLNIKKLCNKKPKAVLKFLSGSYDGDSEEIHRNFPSYRDKASIVYWRNNIIVFGGYGSNFIRSEIQDNIDQGHNFLADNGEYVSGSGNRGWNNQLLIFSMSTNRWTNPATFGCI-----PCPRAAHSSAITDSKLFIFGGRLGMKNTAATVRSNEFYYLDLITFYWTKINLSDSASIIGRSWTTLTCVYDEVFFIVGGFSGDNVPLSDAYIVKI 1220
             CC + N +Y+FGG S +                   T   ++ +L  K  K     +SGS            P  ++ A++V  +  +IVFGG+                      N  +         +N + I   +T  W++P + G       PC RA H++ I + ++ +FGG           R N+ + LDL    W+   L       GR   +   V D+   I+GG  G N+  SD +++ +
Sbjct:   92 GCCVSRNSMYIFGGCSPSN------------------TAFNDVFELDLKDHKWTRLRISGSP-----------PPPKECATMVAHKKRVIVFGGW------------CQPSRTGCVSNARF---------HNDVHILDTTTLTWSSPCSKGVATGTIQPCERAGHAACIVEDRMIVFGG------AQRQSRFNDVWVLDLNDMQWS-TPLVRGRRPSGRFGHSQVAVNDKTILIIGGCGGPNMLFSDVWLLDL 287          
BLAST of F-box only protein 42 vs. Ensembl Nematostella
Match: EDO35696 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7SKT8])

HSP 1 Score: 54.6842 bits (130), Expect = 4.650e-8
Identity = 37/122 (30.33%), Postives = 60/122 (49.18%), Query Frame = 3
Query:  861 GWNNQLLIFSMSTNRWTNPATFGCIPCPRAAHSSAITDSKLFIFGGRLGMKNTAATVRSNEFYYLDLITFYWTKINLSDSASIIGRSWTTLTCVYDEVFFIVGGFSGDNVPLSDAYIVKIDN 1226
            G +N + + ++S+  W  P T G  P PR+ HSS + DSKL IFGG        A    N+ + LD+    ++K  ++ +     RSW     +      I GGF G +   +D +I ++D+
Sbjct:  140 GCSNDVHVLNLSSKNWYMPITSGDKPTPRSGHSSCLLDSKLVIFGGW------DAPTCYNDMFLLDMTFIEFSKPPVTGTTPSP-RSWHASVQLPGNKMLISGGFDGIHT-TNDTFIFELDS 253          
BLAST of F-box only protein 42 vs. Ensembl Nematostella
Match: EDO28608 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7T602])

HSP 1 Score: 50.0618 bits (118), Expect = 2.256e-6
Identity = 36/113 (31.86%), Postives = 49/113 (43.36%), Query Frame = 3
Query:  837 YVSGSGNRGW-NNQLLIFSMSTNRWTNPATFGCIPCPRAAHSSAITDSKLFIFGGRLGMKNTAATVRSNEFYYLDLITFYWTKINLSDSASIIGRSWTTLTCVYDEVFFIVGG 1172
            YV G   RG  NN+L + +     WT   T G IP PR  H+  +   K +I GG  G K        N+ Y  D +T  W  IN         RS  T+   +D+  ++ GG
Sbjct:  433 YVFGGIYRGEANNKLYMLNTGNLTWTPLVTSGQIPPPRCDHACTVIGEKFYISGGSGGEKTWF-----NDLYCFDTVTLIWHYINAQGHLP-FPRSLHTICAYHDKDIYLFGG 539          
BLAST of F-box only protein 42 vs. Ensembl Nematostella
Match: EDO48221 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7RKB8])

HSP 1 Score: 49.6766 bits (117), Expect = 2.661e-6
Identity = 36/113 (31.86%), Postives = 49/113 (43.36%), Query Frame = 3
Query:  837 YVSGSGNRGW-NNQLLIFSMSTNRWTNPATFGCIPCPRAAHSSAITDSKLFIFGGRLGMKNTAATVRSNEFYYLDLITFYWTKINLSDSASIIGRSWTTLTCVYDEVFFIVGG 1172
            YV G   RG  NN+L + +     WT   T G IP PR  H+  +   K +I GG  G K        N+ Y  D +T  W  IN         RS  T+   +D+  ++ GG
Sbjct:  144 YVFGGIYRGEANNKLYMLNTGNLTWTPLVTSGQIPPPRCDHACTVIGEKFYISGGSGGEKTWF-----NDLYCFDTVTLIWHYINAQGHLP-FPRSLHTICAYHDKDIYLFGG 250          
BLAST of F-box only protein 42 vs. Ensembl Medaka
Match: KLHDC2 (kelch domain containing 2 [Source:NCBI gene;Acc:101160276])

HSP 1 Score: 130.568 bits (327), Expect = 3.080e-32
Identity = 85/296 (28.72%), Postives = 137/296 (46.28%), Query Frame = 3
Query:  696 PSYRDKASIVYWRNNIIVFGGYG-----SNFIRSEIQDNIDQGHNFLADNGEYVSGSGNRGWNNQLLIFSMSTNRWTNPATFGCIPCPRAAHSSAITDSKLFIFGGRLGMKNTAATVRSNEFYYLDLITFYWTKINLSDSASIIGRSWTTLTCVYDEVFFIVGGFSGDNVPLSDAYIVKIDNKPNVGKVTAKLRCFQSANWDPYIDRSSWNTSELFTPASRMWHSSCLAADGFIYIIGGCRNDLASXXXXXXXXXXXXXP-EPLPLYRLCLWSVFLLKPNLNEHE--IPQKLFNDL 1559
            PS +DK      RN ++ FGGYG     S+    E  ++   G++           S  RGWNN + +  + T  W+ P T G  P PRAAH+ A   ++ ++FGGR  M       R N+ YY+DL T+ W ++++      +GRSW + T V  +  F+ GGF+ +   LSDA+                L C     W P+            T + R+WH++C   DG +++ GGC N+L S      +    +   +P  L RLC+ ++   + +L+ +   +P+ L   L
Sbjct:  180 PSSKDKLGCWVHRNRLVFFGGYGYAPQGSHRGTFEYDESSSLGYD-----------SPGRGWNNHIHVLDLETLSWSQPITHGNTPSPRAAHACATVGNRGYVFGGRFKMH------RLNDLYYIDLDTWEWHEMSVPQLGP-VGRSWHSFTPVSSDHIFLFGGFTTERETLSDAW----------------LYCVSKNEWRPF--------KHNHTESPRLWHTACSGPDGEVFVFGGCANNLLSHRRAAHSNELLVFSVQPKSLVRLCMETILQHREHLSSYWDCLPKHLLYSL 433          
BLAST of F-box only protein 42 vs. Ensembl Medaka
Match: ENSORLT00000027935.1 (kelch domain containing 1 [Source:NCBI gene;Acc:101174144])

HSP 1 Score: 113.235 bits (282), Expect = 1.346e-26
Identity = 110/418 (26.32%), Postives = 174/418 (41.63%), Query Frame = 3
Query:  237 FSELIEPPMAHVSASIGHNIFLI-GGYRITFDNDLRTIIAFDKNNLLYYNVLNSQLDTVELSYDMESVGSFPTEFFCASGMACCSNGNRIYLFGGYSLTKQEVVNALYYIEISKSIDFTGLLNIKKLCNKKPKAVLKFLSGSYDGDSEEIHRNFPSYRDKASIVYWRNNIIVFGGYGSNFIRSEIQDNIDQGHNFLADNGEYVSGSGNRGWNNQLLIFSMSTNRWTNPATFGCIPCPRAAHSSAITDSKLFIFGGRLGMKNTAATVRSNEFYYLDLITFYWTKINLSDSASIIGRSWTTLTCVYDEVFFIVGGFSGDNVPLSDAYIVKIDNKPNVGKVTAKLRCFQSANWDPYIDRSSWNTSELFTPASRMWHSSCLAADGFIYIIGGCRNDLASXXXXXXXXXXXXXPEPLPLYRLC 1487
             S+L+    +  SA + +N+  + GGY    D +    I      +  Y++         ++      G  P      SG   C   + +Y+FGG     Q   N +Y ++++      G    +K+  K   A                    PS RDK S   + + +I FGGYG    R  + D   +  NF+AD   +VS     GWNN++ +F  S   W +P T G  P PRAAH+ A    K +I GGR+         R+++ + LDL ++ W++I    S S +GRSW TLT V D   F+ GG S D  P+SD ++  ++ K                 W  +           F    R+WHS+ +A D  + + GG  + +              + +P PL+R+C
Sbjct:    9 LSQLVARERSGHSAVVVNNLLHVWGGYMSVSDEE----IFLPGGEIWVYDLEGGTWQVFHMT------GEVPPSM---SGSCSCFLNDHLYIFGGCDDNGQ--TNQMYCVDLTD-----GKYEWRKMAPKSGSA--------------------PSPRDKLSCWLYNDRLIYFGGYG----RKLLTDINSRSRNFIADEASWVS-DAFWGWNNEVHVFDPSEVSWNDPQTHGRAPAPRAAHAGATLGCKGYICGGRV------RETRTSDIHCLDLESWTWSEI-APLSTSPVGRSWHTLTAVSDTTMFLFGGLSVDCKPMSDGWLFDVETK----------------QWTEF--------EHPFQNKPRLWHSASVAKDADVVVFGGSCDYILLVDSGHCNDAIVFQTQPYPLFRIC 350          
BLAST of F-box only protein 42 vs. Ensembl Medaka
Match: ENSORLT00000016135.2 (kelch domain containing 1 [Source:NCBI gene;Acc:101174144])

HSP 1 Score: 112.849 bits (281), Expect = 2.199e-26
Identity = 110/418 (26.32%), Postives = 174/418 (41.63%), Query Frame = 3
Query:  237 FSELIEPPMAHVSASIGHNIFLI-GGYRITFDNDLRTIIAFDKNNLLYYNVLNSQLDTVELSYDMESVGSFPTEFFCASGMACCSNGNRIYLFGGYSLTKQEVVNALYYIEISKSIDFTGLLNIKKLCNKKPKAVLKFLSGSYDGDSEEIHRNFPSYRDKASIVYWRNNIIVFGGYGSNFIRSEIQDNIDQGHNFLADNGEYVSGSGNRGWNNQLLIFSMSTNRWTNPATFGCIPCPRAAHSSAITDSKLFIFGGRLGMKNTAATVRSNEFYYLDLITFYWTKINLSDSASIIGRSWTTLTCVYDEVFFIVGGFSGDNVPLSDAYIVKIDNKPNVGKVTAKLRCFQSANWDPYIDRSSWNTSELFTPASRMWHSSCLAADGFIYIIGGCRNDLASXXXXXXXXXXXXXPEPLPLYRLC 1487
             S+L+    +  SA + +N+  + GGY    D +    I      +  Y++         ++      G  P      SG   C   + +Y+FGG     Q   N +Y ++++      G    +K+  K   A                    PS RDK S   + + +I FGGYG    R  + D   +  NF+AD   +VS     GWNN++ +F  S   W +P T G  P PRAAH+ A    K +I GGR+         R+++ + LDL ++ W++I    S S +GRSW TLT V D   F+ GG S D  P+SD ++  ++ K                 W  +           F    R+WHS+ +A D  + + GG  + +              + +P PL+R+C
Sbjct:    9 LSQLVARERSGHSAVVVNNLLHVWGGYMSVSDEE----IFLPGGEIWVYDLEGGTWQVFHMT------GEVPPSM---SGSCSCFLNDHLYIFGGCDDNGQ--TNQMYCVDLTD-----GKYEWRKMAPKSGSA--------------------PSPRDKLSCWLYNDRLIYFGGYG----RKLLTDINSRSRNFIADEASWVS-DAFWGWNNEVHVFDPSEVSWNDPQTHGRAPAPRAAHAGATLGCKGYICGGRV------RETRTSDIHCLDLESWTWSEI-APLSTSPVGRSWHTLTAVSDTTMFLFGGLSVDCKPMSDGWLFDVETK----------------QWTEF--------EHPFQNKPRLWHSASVAKDADVVVFGGSCDYILLVDSGHCNDAIVFQTQPYPLFRIC 350          
BLAST of F-box only protein 42 vs. Ensembl Medaka
Match: ENSORLT00000014608.2 (kelch domain-containing protein 1 [Source:NCBI gene;Acc:101165264])

HSP 1 Score: 99.7525 bits (247), Expect = 3.688e-22
Identity = 89/382 (23.30%), Postives = 160/382 (41.88%), Query Frame = 3
Query:  264 AHVSASIGHNIFLIGGYRITFDNDLRTIIAFDKNNLLYYNVLNSQLDTVELSYDMESVGSFPTEFFCASGMACCSNGNRIYLFGGYSLTKQEVVNALYYIEISKSIDFTGLLNIKKLCNKKPKAVLKFLSGSYDGDSEEIHRNFPSYRDKASIVYWRNNIIVFGGYGSNFIRSEIQDNIDQGHNFLADNGEYVSGSGNR----GWNNQLLIFSMSTNRWTNPATFGCIPCPRAAHSSAITDSKLFIFGGRLGMKNTAATVRSNEFYYLDLITFYWTKINLSDSASIIGRSWTTLTCVYDEVFFIVGGFSGDNVPLSDAYIVKIDNKPNVGKVTAKLRCFQSANWDPYIDRSSWNTSELFTPASRMWHSSCLAADGFIYIIGG 1397
            +H +   G+ ++  GGY++    D    +    N +   ++ +   +  E++ D+       +  FC S +      + +Y+FGG         N ++ +++SK        + +K+ N   K                     PS R+K S    ++ +I FGGYG   + SE+Q+      +F+ +   + +         GWN+++ +F   T+ W+ P T G  P PR  H+SA+  +K FI GG              + + LDL T+ WT+ +   S + +GRS  T+T + D   F+ GG   D   LSDA++     +    KVT + +                          R+ H++CL +DG + + GG
Sbjct:    9 SHTAFIHGNTLYAWGGYQVVAGQD----VVLPSNEIWLCDLDSGMWERKEMTGDIPP----HSPGFCGSNI-----NSTLYVFGG--CDPGGYSNQMFSVDMSKPC-----CSWRKVLNSTGKT--------------------PSPRNKHSCWVHKDRLIYFGGYGCKTM-SEVQNAFPS--SFIVEEMSWTTIGDTLFQCLGWNSEVNVFDTRTSTWSMPETRGSAPSPRGCHASALLGNKGFITGG--------VETAELDIFCLDLETWTWTQFDFQLSCAPLGRSMHTMTSMSDHTIFVYGGLGTDGNTLSDAWLFNAKRR-EWTKVTHQHK-----------------------DKPRVCHTACLGSDGNVVVFGG 315          
BLAST of F-box only protein 42 vs. Ensembl Medaka
Match: fbxo42 (F-box protein 42 [Source:NCBI gene;Acc:101172058])

HSP 1 Score: 62.003 bits (149), Expect = 1.382e-9
Identity = 46/181 (25.41%), Postives = 86/181 (47.51%), Query Frame = 3
Query:  690 NFPSYRDKASIVYWRNNIIVFGGY--GSNFIRSEIQDNIDQGHNFLADNGEYVSGSGNRGWNNQLLIFSMSTNRWTNPATFGCIPCPRAAHSSAITDSKLFIFGGRLGMKNTAATVRSNEFYYLDLITFYWTKINLSDSASIIGRSWTTLTCVYDEVFFIVGGFSGDNVPLSDAYIVKIDN 1226
            ++PS +  A++V  ++ +++FGG+   S +   + +   D+ H +          S ++ W N ++             T G  P P A HSS++  + + +FGG LG +       SNE + LDL  + W+K  +S   S   R   +   + ++   I+GG  G N  L DA+++ +D+
Sbjct:  177 SYPSPKAGATLVMHKDLLVLFGGWTRPSPYPLHQPERFFDEIHTY----------SPSKNWWNCIVT------------THG--PPPMAGHSSSVIRNNMVVFGGSLGARQM-----SNEVWVLDLEQWAWSKPAVS-GPSPHPRGGQSQIVIDEKTLLILGGCGGPNALLKDAWLLHMDS 327          
BLAST of F-box only protein 42 vs. Planmine SMEST
Match: SMESG000050514.1 (SMESG000050514.1)

HSP 1 Score: 905.975 bits (2340), Expect = 0.000e+0
Identity = 454/457 (99.34%), Postives = 455/457 (99.56%), Query Frame = 3
Query:  204 MEYIISFDSSKFSELIEPPMAHVSASIGHNIFLIGGYRITFDNDLRTIIAFDKNNLLYYNVLNSQLDTVELSYDMESVGSFPTEFFCASGMACCSNGNRIYLFGGYSLTKQEVVNALYYIEISKSIDFTGLLNIKKLCNKKPKAVLKFLSGSYDGDSEEIHRNFPSYRDKASIVYWRNNIIVFGGYGSNFIRSEIQDNIDQGHNFLADNGEYVSGSGNRGWNNQLLIFSMSTNRWTNPATFGCIPCPRAAHSSAITDSKLFIFGGRLGMKNTAATVRSNEFYYLDLITFYWTKINLSDSASIIGRSWTTLTCVYDEVFFIVGGFSGDNVPLSDAYIVKIDNKPNVGKVTAKLRCFQSANWDPYIDRSSWNTSELFTPASRMWHSSCLAADGFIYIIGGCRNDLASXXXXXXXXXXXXXPEPLPLYRLCLWSVFLLKPNLNEHEIPQKLFNDLLSLCF 1574
            MEYIISFDSSKFSELIEPPMAHVSASIGHNIFLIGGYRITFDNDLRTIIAFDKNNLLYYNVLNSQLDTVELSYDMESVGSFPTEFFCASGMACCSNGNRIYLFGGYSLTKQEVVNALYYIEISKSIDFTGLLNIKKLCNKKPKAVLKFLSGS+DGDSEEIHRNFPSYRDKASIVYWRNNIIVFGGYGSNFIRSEIQDNIDQGHNFLADNGEYVSGSGNRGWNNQLLIFSMSTNRWTNPATFG IPCPRAAHSSAITDSKLFIFGGRLGMKNTAATVRSNEFYYLDLITFYWTKINLSDSASIIGRSWTTLTCVYDEVFFIVGGFSGDNVPLSDAYIVKID KPNVGKVTAKLRCFQSANWDPYIDRSSWNTSELFTPASRMWHSSCLAADGFIYIIGGCRNDLASQIERIQTRIERIRPEPLPLYRLCLWSVFLLKPNLNEHEIPQKLFNDLLSLCF
Sbjct:    1 MEYIISFDSSKFSELIEPPMAHVSASIGHNIFLIGGYRITFDNDLRTIIAFDKNNLLYYNVLNSQLDTVELSYDMESVGSFPTEFFCASGMACCSNGNRIYLFGGYSLTKQEVVNALYYIEISKSIDFTGLLNIKKLCNKKPKAVLKFLSGSHDGDSEEIHRNFPSYRDKASIVYWRNNIIVFGGYGSNFIRSEIQDNIDQGHNFLADNGEYVSGSGNRGWNNQLLIFSMSTNRWTNPATFGSIPCPRAAHSSAITDSKLFIFGGRLGMKNTAATVRSNEFYYLDLITFYWTKINLSDSASIIGRSWTTLTCVYDEVFFIVGGFSGDNVPLSDAYIVKIDKKPNVGKVTAKLRCFQSANWDPYIDRSSWNTSELFTPASRMWHSSCLAADGFIYIIGGCRNDLASQIERIQTRIERIRPEPLPLYRLCLWSVFLLKPNLNEHEIPQKLFNDLLSLCF 457          
BLAST of F-box only protein 42 vs. Planmine SMEST
Match: SMESG000077083.1 (SMESG000077083.1)

HSP 1 Score: 57.3806 bits (137), Expect = 2.298e-8
Identity = 53/180 (29.44%), Postives = 91/180 (50.56%), Query Frame = 3
Query:  648 LSGSYDGDSEEIHRNFPSYRDKASIVYWRNNIIVFGGYGSNFIRSEIQDNIDQGHNFLADNGEYVSGSGNRGWNNQLLIFSMSTNRWT-NPATFGCIPCPRAAHSSAITDSKLFIFGGRLGMKNTAATVRSNEFYYLDLITFYWTKINLSDSASIIGRSWTTLTCVYDEVFFIVGGFSGD 1184
            L+ S+D +++ I  N P  R   ++V W+   I+FGG+ ++ + +    +  + + F+ +    +    NR    ++L  S+++N W       G IP  R  HS+ I    +F+FGG   + +T A    N+ Y LDLIT+ WT I   D    +GR + TLT   + + ++ GG S D
Sbjct:   59 LTYSWDCNTDGIDSNKPFDRYGHTVVKWKKIGILFGGFPNSSLTASSSSS--EIYLFVPN----IECLPNRL---KVLNNSINSNFWVLVDGVRGSIPEKRDGHSADIYYDVMFLFGG---LTSTGARYFDNKLYQLDLITWQWTIIYNGDYVEPLGRDFCTLTTCKNSL-YLFGGRSDD 225          
BLAST of F-box only protein 42 vs. Planmine SMEST
Match: SMESG000068250.1 (SMESG000068250.1)

HSP 1 Score: 50.0618 bits (118), Expect = 5.374e-6
Identity = 54/224 (24.11%), Postives = 90/224 (40.18%), Query Frame = 3
Query:  438 GSFPTEFFCAS-GMACCSNGNRIYLFGGYSLTKQEVVNALYYIEISKSIDFTGLLNIKKLCNKKPKAVLKFLSGSYDGDSEEIHRNFPSYRDKASIVYWRNNIIVFGGYGSNFIRSEIQDNIDQGHNFLADNGEYVSGSGNRGWNNQLLIFSMSTNRWTNPATFGCIPCPRAAHSSAITDSKLFIFGGRLGM---KNTAATVR----SNEFYYLDLITFYWTKI 1085
            GS P    CA  G +    GN++YLFGG +   ++                    NI +  N      +K   G+   ++  +  + P+ R+  S V ++                 IQ N DQ    L      V G  ++     + I ++ T  WT P   G IP PR+ HS+ +  +K++IFGG + +    N  +  +    +N  + LDL T  W ++
Sbjct:  122 GSLP----CARIGHSLTLIGNKMYLFGGLANDSED-----------------AKFNIPRYLNDLYVLDIKAAQGTMMWETPSMKGSIPTPRESHSAVAYQ----------------LIQQNSDQTQWKL-----LVYGGMHKFRYGDVYILNVDTMSWTKPTIGGEIPQPRSLHSATLVGNKMYIFGGWVPLVLDDNRNSQEKEWKCTNSVHRLDLETLSWDRV 303          
BLAST of F-box only protein 42 vs. Planmine SMEST
Match: SMESG000068250.1 (SMESG000068250.1)

HSP 1 Score: 50.0618 bits (118), Expect = 5.378e-6
Identity = 54/224 (24.11%), Postives = 90/224 (40.18%), Query Frame = 3
Query:  438 GSFPTEFFCAS-GMACCSNGNRIYLFGGYSLTKQEVVNALYYIEISKSIDFTGLLNIKKLCNKKPKAVLKFLSGSYDGDSEEIHRNFPSYRDKASIVYWRNNIIVFGGYGSNFIRSEIQDNIDQGHNFLADNGEYVSGSGNRGWNNQLLIFSMSTNRWTNPATFGCIPCPRAAHSSAITDSKLFIFGGRLGM---KNTAATVR----SNEFYYLDLITFYWTKI 1085
            GS P    CA  G +    GN++YLFGG +   ++                    NI +  N      +K   G+   ++  +  + P+ R+  S V ++                 IQ N DQ    L      V G  ++     + I ++ T  WT P   G IP PR+ HS+ +  +K++IFGG + +    N  +  +    +N  + LDL T  W ++
Sbjct:  122 GSLP----CARIGHSLTLIGNKMYLFGGLANDSED-----------------AKFNIPRYLNDLYVLDIKAAQGTMMWETPSMKGSIPTPRESHSAVAYQ----------------LIQQNSDQTQWKL-----LVYGGMHKFRYGDVYILNVDTMSWTKPTIGGEIPQPRSLHSATLVGNKMYIFGGWVPLVLDDNRNSQEKEWKCTNSVHRLDLETLSWDRV 303          
The following BLAST results are available for this feature:
BLAST of F-box only protein 42 vs. Ensembl Human
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Human e!99)
Total hits: 5
Match NameE-valueIdentityDescription
KLHDC24.658e-3427.05kelch domain containing 2 [Source:HGNC Symbol;Acc:... [more]
KLHDC26.213e-3426.82kelch domain containing 2 [Source:HGNC Symbol;Acc:... [more]
KLHDC13.582e-3227.42kelch domain containing 1 [Source:HGNC Symbol;Acc:... [more]
KLHDC25.151e-2728.31kelch domain containing 2 [Source:HGNC Symbol;Acc:... [more]
KLHDC13.233e-2632.51kelch domain containing 1 [Source:HGNC Symbol;Acc:... [more]
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BLAST of F-box only protein 42 vs. Ensembl Celegans
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99)
Total hits: 5
Match NameE-valueIdentityDescription
F53E4.11.559e-823.77pep chromosome:WBcel235:V:15652438:15659079:-1 gen... [more]
F53E4.11.559e-823.77pep chromosome:WBcel235:V:15652438:15659067:-1 gen... [more]
F53E4.17.825e-823.11pep chromosome:WBcel235:V:15652438:15668300:-1 gen... [more]
F53E4.18.207e-823.11pep chromosome:WBcel235:V:15652438:15659079:-1 gen... [more]
F53E4.18.207e-823.11pep chromosome:WBcel235:V:15652438:15659067:-1 gen... [more]
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BLAST of F-box only protein 42 vs. Ensembl Fly
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99)
Total hits: 2
Match NameE-valueIdentityDescription
CG120818.030e-620.92gene:FBgn0030053 transcript:FBtr0332626[more]
CG120818.030e-620.92gene:FBgn0030053 transcript:FBtr0071218[more]
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BLAST of F-box only protein 42 vs. Ensembl Zebrafish
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99)
Total hits: 5
Match NameE-valueIdentityDescription
krcp1.576e-830.33kelch repeat-containing protein [Source:ZFIN;Acc:Z... [more]
lztr15.316e-826.14leucine-zipper-like transcription regulator 1 [Sou... [more]
lztr15.743e-826.14leucine-zipper-like transcription regulator 1 [Sou... [more]
lztr15.965e-826.14leucine-zipper-like transcription regulator 1 [Sou... [more]
zgc:1630148.887e-629.29zgc:163014 [Source:ZFIN;Acc:ZDB-GENE-070424-100][more]
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BLAST of F-box only protein 42 vs. Ensembl Xenopus
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99)
Total hits: 5
Match NameE-valueIdentityDescription
polr2b1.161e-3626.71polymerase (RNA) II (DNA directed) polypeptide B, ... [more]
polr2b2.995e-3626.78polymerase (RNA) II (DNA directed) polypeptide B, ... [more]
polr2b1.626e-3530.43polymerase (RNA) II (DNA directed) polypeptide B, ... [more]
trpm61.773e-1025.68transient receptor potential cation channel, subfa... [more]
ENSXETT00000037226.12.963e-732.48rab9 effector protein with kelch motifs [Source:NC... [more]
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BLAST of F-box only protein 42 vs. Ensembl Mouse
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99)
Total hits: 5
Match NameE-valueIdentityDescription
Klhdc23.382e-3426.64kelch domain containing 2 [Source:MGI Symbol;Acc:M... [more]
Klhdc13.702e-3326.74kelch domain containing 1 [Source:MGI Symbol;Acc:M... [more]
Klhdc19.359e-2929.45kelch domain containing 1 [Source:MGI Symbol;Acc:M... [more]
Fbxo421.223e-1024.23F-box protein 42 [Source:MGI Symbol;Acc:MGI:192499... [more]
Lztr11.253e-625.00leucine-zipper-like transcriptional regulator, 1 [... [more]
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BLAST of F-box only protein 42 vs. UniProt/SwissProt
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt)
Total hits: 5
Match NameE-valueIdentityDescription
sp|Q4G5Y1|KLDC2_MOUSE2.366e-3326.64Kelch domain-containing protein 2 OS=Mus musculus ... [more]
sp|Q9Y2U9|KLDC2_HUMAN2.984e-3326.82Kelch domain-containing protein 2 OS=Homo sapiens ... [more]
sp|Q3KRE6|KLDC2_RAT1.411e-3226.35Kelch domain-containing protein 2 OS=Rattus norveg... [more]
sp|Q5E9A7|KLDC2_BOVIN2.516e-3226.59Kelch domain-containing protein 2 OS=Bos taurus OX... [more]
sp|Q80YG3|KLDC1_MOUSE2.590e-3226.74Kelch domain-containing protein 1 OS=Mus musculus ... [more]
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BLAST of F-box only protein 42 vs. TrEMBL
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL)
Total hits: 5
Match NameE-valueIdentityDescription
T1E6631.432e-3327.54Kelch domain-containing protein 2-like protein OS=... [more]
A0A0K8S0891.742e-3327.54Kelch domain-containing protein 2-like protein OS=... [more]
A0A5G3IXI41.822e-3326.71Polymerase (RNA) II (DNA directed) polypeptide B, ... [more]
A0A0L8GWH42.402e-3329.80Uncharacterized protein OS=Octopus bimaculoides OX... [more]
A0A1L8F9S03.375e-3326.95Uncharacterized protein OS=Xenopus laevis OX=8355 ... [more]
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BLAST of F-box only protein 42 vs. Ensembl Cavefish
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99)
Total hits: 5
Match NameE-valueIdentityDescription
klhdc21.529e-2926.03kelch domain containing 2 [Source:ZFIN;Acc:ZDB-GEN... [more]
ENSAMXT00000006485.26.271e-1326.29kelch domain-containing protein 1-like [Source:NCB... [more]
fbxo423.240e-1023.36F-box protein 42 [Source:NCBI gene;Acc:103041203][more]
ENSAMXT00000020761.23.557e-1027.87pep primary_assembly:Astyanax_mexicanus-2.0:9:4299... [more]
fbxo423.871e-1023.36F-box protein 42 [Source:NCBI gene;Acc:103041203][more]
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BLAST of F-box only protein 42 vs. Ensembl Sea Lamprey
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99)
Total hits: 5
Match NameE-valueIdentityDescription
KLHDC24.615e-2830.42kelch domain containing 2 [Source:HGNC Symbol;Acc:... [more]
zgc:1630143.060e-931.15zgc:163014 [Source:ZFIN;Acc:ZDB-GENE-070424-100][more]
zgc:1630143.471e-931.15zgc:163014 [Source:ZFIN;Acc:ZDB-GENE-070424-100][more]
lztr18.009e-826.14leucine-zipper-like transcription regulator 1 [Sou... [more]
ENSPMAT00000001771.19.325e-734.02pep scaffold:Pmarinus_7.0:GL480830:19416:31634:1 g... [more]
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BLAST of F-box only protein 42 vs. Ensembl Yeast
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46)
Total hits: 0
Match NameE-valueIdentityDescription
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BLAST of F-box only protein 42 vs. Ensembl Nematostella
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46)
Total hits: 5
Match NameE-valueIdentityDescription
EDO492789.066e-2225.78Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7... [more]
EDO426231.777e-922.53Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7... [more]
EDO356964.650e-830.33Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7... [more]
EDO286082.256e-631.86Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7... [more]
EDO482212.661e-631.86Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7... [more]
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BLAST of F-box only protein 42 vs. Ensembl Medaka
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99)
Total hits: 5
Match NameE-valueIdentityDescription
KLHDC23.080e-3228.72kelch domain containing 2 [Source:NCBI gene;Acc:10... [more]
ENSORLT00000027935.11.346e-2626.32kelch domain containing 1 [Source:NCBI gene;Acc:10... [more]
ENSORLT00000016135.22.199e-2626.32kelch domain containing 1 [Source:NCBI gene;Acc:10... [more]
ENSORLT00000014608.23.688e-2223.30kelch domain-containing protein 1 [Source:NCBI gen... [more]
fbxo421.382e-925.41F-box protein 42 [Source:NCBI gene;Acc:101172058][more]
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BLAST of F-box only protein 42 vs. Planmine SMEST
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST)
Total hits: 4
Match NameE-valueIdentityDescription
SMESG000050514.10.000e+099.34SMESG000050514.1[more]
SMESG000077083.12.298e-829.44SMESG000077083.1[more]
SMESG000068250.15.374e-624.11SMESG000068250.1[more]
SMESG000068250.15.378e-624.11SMESG000068250.1[more]
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Sequences
The following sequences are available for this feature:

transcript sequence

>SMED30012729 ID=SMED30012729|Name=F-box only protein 42|organism=Schmidtea mediterranea sexual|type=transcript|length=1865bp
TATTGTTATTATTATTATTTATTATAATAGATTATAATTTATATATTGAT
TATTTTTATCGTTATTATATTTATCATTAATATTTAAACTTTATTTTAAA
AATTATTATAATTTTTATTTATTTATTAGAATTGTTTTTAGAATAATAAT
GTTAATCTAATAAATTATTTTATATTTAAATTATATTGTAATTTTGTATC
AAAATGGAATATATAATTAGTTTTGATTCCTCAAAGTTTTCTGAGTTAAT
TGAGCCACCTATGGCTCATGTATCGGCATCGATAGGACATAATATATTTT
TGATCGGAGGATATCGAATAACTTTTGATAATGATCTTCGCACAATAATT
GCTTTTGATAAAAATAATCTGCTTTATTATAATGTTTTAAACAGCCAACT
GGATACTGTCGAATTATCCTACGATATGGAATCTGTCGGTTCATTTCCAA
CTGAATTCTTTTGTGCATCTGGCATGGCTTGTTGTTCCAATGGTAACAGA
ATATATTTATTTGGTGGCTATTCTTTAACCAAACAAGAAGTCGTAAACGC
TTTGTATTATATTGAAATAAGTAAATCTATCGATTTTACTGGATTATTAA
ATATTAAGAAATTATGTAACAAAAAACCGAAAGCTGTACTTAAGTTTTTA
TCTGGTTCCTATGATGGCGATAGTGAAGAAATTCATAGAAATTTCCCATC
ATATAGAGATAAAGCTTCAATAGTTTATTGGAGGAATAATATCATTGTTT
TTGGTGGTTACGGTTCTAATTTCATTCGATCTGAAATCCAAGACAATATT
GACCAAGGTCACAATTTTCTTGCCGATAATGGTGAATATGTATCCGGTAG
CGGCAATAGAGGTTGGAATAACCAATTACTGATATTTTCAATGTCAACAA
ATCGATGGACTAATCCCGCTACATTTGGATGTATTCCGTGTCCTCGAGCT
GCTCACTCCTCCGCAATCACGGACAGCAAACTTTTCATATTCGGTGGTAG
ATTAGGAATGAAAAATACCGCAGCAACAGTTCGATCAAATGAATTTTATT
ATTTGGATTTAATTACTTTTTATTGGACAAAAATCAACTTATCGGATTCT
GCGTCTATCATTGGTCGATCCTGGACAACTCTAACTTGCGTTTATGATGA
GGTTTTTTTCATAGTCGGTGGATTTTCTGGTGACAATGTTCCGTTATCCG
ATGCTTACATTGTGAAAATCGATAATAAACCGAACGTGGGAAAGGTGACA
GCTAAATTGCGCTGCTTCCAAAGTGCCAATTGGGATCCGTATATCGATCG
GAGCAGTTGGAATACATCCGAATTATTCACACCTGCCAGTCGAATGTGGC
ATTCGAGTTGTCTAGCGGCCGATGGATTTATATATATTATTGGCGGTTGC
CGGAACGACCTCGCGTCACAAATTGAACGCATCCAAACCAGAATTGAACG
AATCAGACCGGAACCGTTACCTTTATATCGATTGTGTTTGTGGAGCGTTT
TTCTATTGAAACCGAATCTAAACGAGCACGAAATTCCTCAAAAGCTTTTT
AATGATCTTCTTTCATTATGCTTTTGAAAGGGTGATTTTGTTAACCCATA
TAAACGCGCCGTTGTTCTTTCTATTATTAAAAGTGGTATTTATTGATTAG
TTTTGGTGGGAGATGTTTTAATTTAATCTTTTATTGTCGAATGGTTTGTT
GCTGAATTATTGATTTATTGTTATTAGCCATTGATTAATTTGGACCCGGC
GTTGATTGGTCTCAGTTACTCTATTATTATAACCACAAATTAAATAATTT
TGGCAGCCTCCGTTATTAGTATCGCATGCGACGATAGAAATACTACAAAG
GAAACTCCATGTTGG
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protein sequence of SMED30012729-orf-1

>SMED30012729-orf-1 ID=SMED30012729-orf-1|Name=SMED30012729-orf-1|organism=Schmidtea mediterranea sexual|type=polypeptide|length=458bp
MEYIISFDSSKFSELIEPPMAHVSASIGHNIFLIGGYRITFDNDLRTIIA
FDKNNLLYYNVLNSQLDTVELSYDMESVGSFPTEFFCASGMACCSNGNRI
YLFGGYSLTKQEVVNALYYIEISKSIDFTGLLNIKKLCNKKPKAVLKFLS
GSYDGDSEEIHRNFPSYRDKASIVYWRNNIIVFGGYGSNFIRSEIQDNID
QGHNFLADNGEYVSGSGNRGWNNQLLIFSMSTNRWTNPATFGCIPCPRAA
HSSAITDSKLFIFGGRLGMKNTAATVRSNEFYYLDLITFYWTKINLSDSA
SIIGRSWTTLTCVYDEVFFIVGGFSGDNVPLSDAYIVKIDNKPNVGKVTA
KLRCFQSANWDPYIDRSSWNTSELFTPASRMWHSSCLAADGFIYIIGGCR
NDLASQIERIQTRIERIRPEPLPLYRLCLWSVFLLKPNLNEHEIPQKLFN
DLLSLCF*
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Annotated Terms
The following terms have been associated with this transcript:
Vocabulary: molecular function
TermDefinition
GO:0003676nucleic acid binding
GO:0005515protein binding
Vocabulary: INTERPRO
TermDefinition
IPR015915Kelch-typ_b-propeller
Vocabulary: cellular component
TermDefinition
GO:0031965nuclear membrane
GO:0005634nucleus
GO:0016604nuclear body
InterPro
Analysis Name: Schmidtea mediteranean smed_20140614 Interproscan
Date Performed: 2020-05-01
IPR TermIPR DescriptionSourceSource TermSource DescriptionAlignment
NoneNo IPR availablePFAMPF13854Kelch_5coord: 244..289
e-value: 2.3E-6
score: 27.4
NoneNo IPR availablePANTHERPTHR46228FAMILY NOT NAMEDcoord: 19..450
IPR015915Kelch-type beta propellerGENE3DG3DSA:2.120.10.80coord: 272..421
e-value: 1.5E-10
score: 42.6
coord: 152..271
e-value: 3.0E-5
score: 25.2
IPR015915Kelch-type beta propellerSUPERFAMILYSSF117281Kelch motifcoord: 30..402