Cleavage and polyadenylation specificity factor subunit 1

Overview
NameCleavage and polyadenylation specificity factor subunit 1
Smed IDSMED30012540
Length (bp)1516
Neoblast Clusters

Zeng et. al., 2018



▻ Overview

▻ Neoblast Population

▻ Sub-lethal Irradiated Surviving X1 and X2 Cell Population

 

 

Overview

 

Single cell RNA-seq of pluripotent neoblasts and its early progenies


We isolated X1 neoblasts cells enriched in high piwi-1 expression (Neoblast Population), and profiled ∼7,614 individual cells via scRNA-seq. Unsupervised analyses uncovered 12 distinct classes from 7,088 high-quality cells. We designated these classes Nb1 to Nb12 and ordered them based on high (Nb1) to low (Nb12) piwi-1 expression levels. We further defined groups of genes that best classified the cells parsed into 12 distinct cell clusters to generate a scaled expression heat map of discriminative gene sets for each cluster. Expression of each cluster’s gene signatures was validated using multiplex fluorescence in situ hybridization (FISH) co-stained with piwi-1 and largely confirmed the cell clusters revealed by scRNA-seq.

We also tested sub-lethal irradiation exposure. To profile rare pluripotent stem cells (PSCs) and avoid interference from immediate progenitor cells, we determined a time point after sub-lethal irradiation (7 DPI) with minimal piwi-1+ cells, followed by isolation and single-cell RNA-seq of 1,200 individual cells derived from X1 (Piwi-1 high) and X2 (Piwi-1 low) cell populations (Sub-lethal Irradiated Surviving X1 and X2 Cell Population)



Explore this single cell expression dataset with our NB Cluster Shiny App



 

Neoblast Population

 

t-SNE plot shows two-dimensional representation of global gene expression relationships among all neoblasts (n = 7,088 after filter). Cluster identity was assigned based on the top 10 marker genes of each cluster (Table S2), followed by inspection of RNA in situ hybridization patterns. Neoblast groups, Nb.


Expression of Cleavage and polyadenylation specificity factor subunit 1 (SMED30012540) t-SNE clustered cells

Violin plots show distribution of expression levels for Cleavage and polyadenylation specificity factor subunit 1 (SMED30012540) in cells (dots) of each of the 12 neoblast clusters.

 

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Sub-lethal Irradiated Surviving X1 and X2 Cell Population

 

t-SNE plot of surviving X1 and X2 cells (n = 1,039 after QC filter) after sub-lethal irradiation. Colors indicate unbiased cell classification via graph-based clustering. SL, sub-lethal irradiated cell groups.

Expression of Cleavage and polyadenylation specificity factor subunit 1 (SMED30012540) in the t-SNE clustered sub-lethally irradiated X1 and X2 cells.

Violin plots show distribution of expression levels for Cleavage and polyadenylation specificity factor subunit 1 (SMED30012540) in cells (dots) of each of the 10 clusters of sub-leathally irradiated X1 and X2 cells.

 

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Embryonic Expression

Davies et. al., 2017

Hover the mouse over a column in the graph to view average RPKM values per sample.
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Embryonic Stages: Y: yolk. S2-S8: Stages 2-8. C4: asexual adult. SX: virgin, sexually mature adult.
For further information about sample preparation and analysis for the single animal RNA-Seq experiment, please refer to the Materials and Methods

 

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Anatomical Expression

PAGE et. al., 2020



SMED30012540

has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGE



PAGE Curations: 2

  
Expressed InReference TranscriptGene ModelsPublished TranscriptTranscriptomePublicationSpecimenLifecycleEvidence
X1 cellSMED30012540SMESG000051959.1 SmedASXL_017321SmedAsxl_ww_GCZZ01PMID:26114597
Zhu et al., 2015		FACS sorted cell population asexual adult RNA-sequencing evidence
X2 cellSMED30012540SMESG000051959.1 SmedASXL_017321SmedAsxl_ww_GCZZ01PMID:26114597
Zhu et al., 2015		FACS sorted cell population asexual adult RNA-sequencing evidence
Note: Hover over icons to view figure legend
Homology
[Close]
BLAST of Cleavage and polyadenylation specificity factor subunit 1 vs. Ensembl Human
Match: CPSF1 (cleavage and polyadenylation specific factor 1 [Source:HGNC Symbol;Acc:HGNC:2324])

HSP 1 Score: 322.783 bits (826), Expect = 2.456e-97
Identity = 167/439 (38.04%), Postives = 263/439 (59.91%), Query Frame = 2 
Query:   86 GEMKLLNLPSGYDYEYQKAVKRISMNRSVHFVQFHIDSKTFAIITSEDREVMSIFKLNAENSKEEEPIERDSDIIRAPLPIYTLEFYANELSGLWEPVPHAKVVFEDWDKVSCMTTVQLFSQMTYSGTKDFLAVGSNMSYGEEIPVRGKIMIVDIIDVVPEPGQVLTRHKMKIIYDVEQKGPVTALTSCKGYLVSAIGQKMYIWELKDNELVGVAFVDSEIYVQQLHCVRNLILTGDFLKSIQLLRFQSDLRVLSLVSKDSHARGVTCSNFFVDNENLGFMLADTHANIIIYSYNPLIEESRNGKQLVRNADIKLPITVTCSLRINDRIRDPILYSSSSVTMAQELLRQSVYFGAASGAIFRLSPISNKQLIQMKLTEKNLSQCLHHHGGLLPKSSRQYKFTHPELSNACGNIADGDLLAQYVTLPYSQRTEIAKKAGV 1402
            GE+++  LP+   Y+    V++I +  + H+V +H++SK +A+ TS +     I ++  E  KE E IERD   I      ++++  +      WE +P+A++  ++W+ V+CM TV L S+ T SG K ++A G+ +  GEE+  RG+I+I+D+I+VVPEPGQ LT++K K++Y+ EQKGPVTAL  C G+LVSAIGQK+++W L+ +EL G+AF+D+++Y+ Q+  V+N IL  D +KSI LLR+Q + + LSLVS+D+    V   +F VDN  LGF+++D   N+++Y Y P  +ES  G +L+R AD  +   V    R   R     L   S V   + +     +F    G I  L P+  K   ++ + +  L+  L HH GL P++ R        L NA  N+ DG+LL +Y+ L   +R+E+AKK G 
Sbjct:  994 GELRISVLPAYLSYDAPWPVRKIPLRCTAHYVAYHVESKVYAVATSTNTPCARIPRMTGEE-KEFETIERDERYIHPQQEAFSIQLIS---PVSWEAIPNARIELQEWEHVTCMKTVSLRSEETVSGLKGYVAAGTCLMQGEEVTCRGRILIMDVIEVVPEPGQPLTKNKFKVLYEKEQKGPVTALCHCNGHLVSAIGQKIFLWSLRASELTGMAFIDTQLYIHQMISVKNFILAADVMKSISLLRYQEESKTLSLVSRDAKPLEVYSVDFMVDNAQLGFLVSDRDRNLMVYMYLPEAKESFGGMRLLRRADFHVGAHVNTFWRTPCRGATEGLSKKSVVWENKHI----TWFATLDGGIGLLLPMQEKTYRRLLMLQNALTTMLPHHAGLNPRAFRMLHVDRRTLQNAVRNVLDGELLNRYLYLSTMERSELAKKIGT 1424
[Close]
BLAST of Cleavage and polyadenylation specificity factor subunit 1 vs. Ensembl Human
Match: CPSF1 (cleavage and polyadenylation specific factor 1 [Source:HGNC Symbol;Acc:HGNC:2324])

HSP 1 Score: 322.783 bits (826), Expect = 2.456e-97
Identity = 167/439 (38.04%), Postives = 263/439 (59.91%), Query Frame = 2 
Query:   86 GEMKLLNLPSGYDYEYQKAVKRISMNRSVHFVQFHIDSKTFAIITSEDREVMSIFKLNAENSKEEEPIERDSDIIRAPLPIYTLEFYANELSGLWEPVPHAKVVFEDWDKVSCMTTVQLFSQMTYSGTKDFLAVGSNMSYGEEIPVRGKIMIVDIIDVVPEPGQVLTRHKMKIIYDVEQKGPVTALTSCKGYLVSAIGQKMYIWELKDNELVGVAFVDSEIYVQQLHCVRNLILTGDFLKSIQLLRFQSDLRVLSLVSKDSHARGVTCSNFFVDNENLGFMLADTHANIIIYSYNPLIEESRNGKQLVRNADIKLPITVTCSLRINDRIRDPILYSSSSVTMAQELLRQSVYFGAASGAIFRLSPISNKQLIQMKLTEKNLSQCLHHHGGLLPKSSRQYKFTHPELSNACGNIADGDLLAQYVTLPYSQRTEIAKKAGV 1402
            GE+++  LP+   Y+    V++I +  + H+V +H++SK +A+ TS +     I ++  E  KE E IERD   I      ++++  +      WE +P+A++  ++W+ V+CM TV L S+ T SG K ++A G+ +  GEE+  RG+I+I+D+I+VVPEPGQ LT++K K++Y+ EQKGPVTAL  C G+LVSAIGQK+++W L+ +EL G+AF+D+++Y+ Q+  V+N IL  D +KSI LLR+Q + + LSLVS+D+    V   +F VDN  LGF+++D   N+++Y Y P  +ES  G +L+R AD  +   V    R   R     L   S V   + +     +F    G I  L P+  K   ++ + +  L+  L HH GL P++ R        L NA  N+ DG+LL +Y+ L   +R+E+AKK G 
Sbjct:  994 GELRISVLPAYLSYDAPWPVRKIPLRCTAHYVAYHVESKVYAVATSTNTPCARIPRMTGEE-KEFETIERDERYIHPQQEAFSIQLIS---PVSWEAIPNARIELQEWEHVTCMKTVSLRSEETVSGLKGYVAAGTCLMQGEEVTCRGRILIMDVIEVVPEPGQPLTKNKFKVLYEKEQKGPVTALCHCNGHLVSAIGQKIFLWSLRASELTGMAFIDTQLYIHQMISVKNFILAADVMKSISLLRYQEESKTLSLVSRDAKPLEVYSVDFMVDNAQLGFLVSDRDRNLMVYMYLPEAKESFGGMRLLRRADFHVGAHVNTFWRTPCRGATEGLSKKSVVWENKHI----TWFATLDGGIGLLLPMQEKTYRRLLMLQNALTTMLPHHAGLNPRAFRMLHVDRRTLQNAVRNVLDGELLNRYLYLSTMERSELAKKIGT 1424
[Close]
BLAST of Cleavage and polyadenylation specificity factor subunit 1 vs. Ensembl Human
Match: CPSF1 (cleavage and polyadenylation specific factor 1 [Source:HGNC Symbol;Acc:HGNC:2324])

HSP 1 Score: 322.783 bits (826), Expect = 2.456e-97
Identity = 167/439 (38.04%), Postives = 263/439 (59.91%), Query Frame = 2 
Query:   86 GEMKLLNLPSGYDYEYQKAVKRISMNRSVHFVQFHIDSKTFAIITSEDREVMSIFKLNAENSKEEEPIERDSDIIRAPLPIYTLEFYANELSGLWEPVPHAKVVFEDWDKVSCMTTVQLFSQMTYSGTKDFLAVGSNMSYGEEIPVRGKIMIVDIIDVVPEPGQVLTRHKMKIIYDVEQKGPVTALTSCKGYLVSAIGQKMYIWELKDNELVGVAFVDSEIYVQQLHCVRNLILTGDFLKSIQLLRFQSDLRVLSLVSKDSHARGVTCSNFFVDNENLGFMLADTHANIIIYSYNPLIEESRNGKQLVRNADIKLPITVTCSLRINDRIRDPILYSSSSVTMAQELLRQSVYFGAASGAIFRLSPISNKQLIQMKLTEKNLSQCLHHHGGLLPKSSRQYKFTHPELSNACGNIADGDLLAQYVTLPYSQRTEIAKKAGV 1402
            GE+++  LP+   Y+    V++I +  + H+V +H++SK +A+ TS +     I ++  E  KE E IERD   I      ++++  +      WE +P+A++  ++W+ V+CM TV L S+ T SG K ++A G+ +  GEE+  RG+I+I+D+I+VVPEPGQ LT++K K++Y+ EQKGPVTAL  C G+LVSAIGQK+++W L+ +EL G+AF+D+++Y+ Q+  V+N IL  D +KSI LLR+Q + + LSLVS+D+    V   +F VDN  LGF+++D   N+++Y Y P  +ES  G +L+R AD  +   V    R   R     L   S V   + +     +F    G I  L P+  K   ++ + +  L+  L HH GL P++ R        L NA  N+ DG+LL +Y+ L   +R+E+AKK G 
Sbjct:  994 GELRISVLPAYLSYDAPWPVRKIPLRCTAHYVAYHVESKVYAVATSTNTPCARIPRMTGEE-KEFETIERDERYIHPQQEAFSIQLIS---PVSWEAIPNARIELQEWEHVTCMKTVSLRSEETVSGLKGYVAAGTCLMQGEEVTCRGRILIMDVIEVVPEPGQPLTKNKFKVLYEKEQKGPVTALCHCNGHLVSAIGQKIFLWSLRASELTGMAFIDTQLYIHQMISVKNFILAADVMKSISLLRYQEESKTLSLVSRDAKPLEVYSVDFMVDNAQLGFLVSDRDRNLMVYMYLPEAKESFGGMRLLRRADFHVGAHVNTFWRTPCRGATEGLSKKSVVWENKHI----TWFATLDGGIGLLLPMQEKTYRRLLMLQNALTTMLPHHAGLNPRAFRMLHVDRRTLQNAVRNVLDGELLNRYLYLSTMERSELAKKIGT 1424
[Close]
BLAST of Cleavage and polyadenylation specificity factor subunit 1 vs. Ensembl Human
Match: CPSF1 (cleavage and polyadenylation specific factor 1 [Source:HGNC Symbol;Acc:HGNC:2324])

HSP 1 Score: 322.783 bits (826), Expect = 2.456e-97
Identity = 167/439 (38.04%), Postives = 263/439 (59.91%), Query Frame = 2 
Query:   86 GEMKLLNLPSGYDYEYQKAVKRISMNRSVHFVQFHIDSKTFAIITSEDREVMSIFKLNAENSKEEEPIERDSDIIRAPLPIYTLEFYANELSGLWEPVPHAKVVFEDWDKVSCMTTVQLFSQMTYSGTKDFLAVGSNMSYGEEIPVRGKIMIVDIIDVVPEPGQVLTRHKMKIIYDVEQKGPVTALTSCKGYLVSAIGQKMYIWELKDNELVGVAFVDSEIYVQQLHCVRNLILTGDFLKSIQLLRFQSDLRVLSLVSKDSHARGVTCSNFFVDNENLGFMLADTHANIIIYSYNPLIEESRNGKQLVRNADIKLPITVTCSLRINDRIRDPILYSSSSVTMAQELLRQSVYFGAASGAIFRLSPISNKQLIQMKLTEKNLSQCLHHHGGLLPKSSRQYKFTHPELSNACGNIADGDLLAQYVTLPYSQRTEIAKKAGV 1402
            GE+++  LP+   Y+    V++I +  + H+V +H++SK +A+ TS +     I ++  E  KE E IERD   I      ++++  +      WE +P+A++  ++W+ V+CM TV L S+ T SG K ++A G+ +  GEE+  RG+I+I+D+I+VVPEPGQ LT++K K++Y+ EQKGPVTAL  C G+LVSAIGQK+++W L+ +EL G+AF+D+++Y+ Q+  V+N IL  D +KSI LLR+Q + + LSLVS+D+    V   +F VDN  LGF+++D   N+++Y Y P  +ES  G +L+R AD  +   V    R   R     L   S V   + +     +F    G I  L P+  K   ++ + +  L+  L HH GL P++ R        L NA  N+ DG+LL +Y+ L   +R+E+AKK G 
Sbjct:  994 GELRISVLPAYLSYDAPWPVRKIPLRCTAHYVAYHVESKVYAVATSTNTPCARIPRMTGEE-KEFETIERDERYIHPQQEAFSIQLIS---PVSWEAIPNARIELQEWEHVTCMKTVSLRSEETVSGLKGYVAAGTCLMQGEEVTCRGRILIMDVIEVVPEPGQPLTKNKFKVLYEKEQKGPVTALCHCNGHLVSAIGQKIFLWSLRASELTGMAFIDTQLYIHQMISVKNFILAADVMKSISLLRYQEESKTLSLVSRDAKPLEVYSVDFMVDNAQLGFLVSDRDRNLMVYMYLPEAKESFGGMRLLRRADFHVGAHVNTFWRTPCRGATEGLSKKSVVWENKHI----TWFATLDGGIGLLLPMQEKTYRRLLMLQNALTTMLPHHAGLNPRAFRMLHVDRRTLQNAVRNVLDGELLNRYLYLSTMERSELAKKIGT 1424
[Close]
BLAST of Cleavage and polyadenylation specificity factor subunit 1 vs. Ensembl Human
Match: CPSF1 (cleavage and polyadenylation specific factor 1 [Source:HGNC Symbol;Acc:HGNC:2324])

HSP 1 Score: 131.724 bits (330), Expect = 1.466e-35
Identity = 71/167 (42.51%), Postives = 97/167 (58.08%), Query Frame = 2 
Query:  569 PGQVLTRHKMKIIYDVEQKGPVTALTSCKGYLVSAIGQKMYIWELKDNELVGVAFVDSEIYVQQLHCVRNLILTGDFLKSIQLLRFQSDLRVLSLVSKDSHARGVTCSNFFVDNENLGFMLADTHANIIIYSYNPLIEESRNGKQLVRNADIKLPITVTCSLRINDR 1069
            PGQ LT++K K++Y+ EQKGPVTAL  C G+LVSAIGQK+YI                     Q+  V+N IL  D +KSI LLR+Q + + LSLVS+D+    V   +F VDN  LGF+++D   N+++Y Y P  +ES  G +L+R AD  +   V    R   R
Sbjct:    2 PGQPLTKNKFKVLYEKEQKGPVTALCHCNGHLVSAIGQKLYI--------------------HQMISVKNFILAADVMKSISLLRYQEESKTLSLVSRDAKPLEVYSVDFMVDNAQLGFLVSDRDRNLMVYMYLPEAKESFGGMRLLRRADFHVGAHVNTFWRTPCR 148
[Close]
BLAST of Cleavage and polyadenylation specificity factor subunit 1 vs. Ensembl Celegans
Match: cpsf-1 (Probable cleavage and polyadenylation specificity factor subunit 1 [Source:UniProtKB/Swiss-Prot;Acc:Q9N4C2])

HSP 1 Score: 256.144 bits (653), Expect = 1.940e-74
Identity = 138/441 (31.29%), Postives = 249/441 (56.46%), Query Frame = 2 
Query:   89 EMKLLNLPSGYDYEYQKAVKRISMNRSVHFVQFHIDSKTFAIITSEDREVMSIFKLNAENSKEEEPIERDSDIIRAPLPIYTLEFYANELSGLWEPVPHAKVVFEDWDKVSCMTTVQLFSQMTYSGTKDFLAVGSNMSYGEEIPVRGKIMIVDIIDVVPEPGQVLTRHKMKIIYDVEQKGPVTALTSCKGYLVSAIGQKMYIWELKDNELVGVAFVDSEIYVQQLHCVRNLILTGDFLKSIQLLRFQSDLRVLSLVSKDSH--ARGVTCSNFFVDNENLGFMLADTHANIIIYSYNPLIEESRNGKQLVRNADIKLPITVTCSLRINDRIRDPILYSSSSVTMAQELLRQSVYFGAASGAIFRLSPISNKQLIQMKLTEKNLSQCLHHHGGLLPKSSRQYKFTHPELSNACG-NIADGDLLAQYVTLPYSQRTEIAKKAGV 1402
            E+++  +   +DYE    VK+I + R++H V++ ++S  +A+++S  +    I+ +   + K+EE  E+D + +    P YTL  ++++    W  VP+ ++ FED + V+    V L S+ T SG +  LA+G+  +YGEE+ VRG+I++ ++I+VVPEP Q  +  K+K+++D EQKGPVT L +  G L+  +GQK++IW+ KDN+L+G++F+D   YV QLH +R + +  D  +S+ L+RFQ D + +S+ S+D    A+    S   VD  ++GF+L+D   NI +++Y P   ES  G++L   A I +   +   +R+        L +       ++  R +  F +  G+   + P++ K   ++   +  +        GL  K SR  K + P ++     N+ DGD++ QY+ L    +T++A++ GV
Sbjct:  810 ELRIARMHPDFDYEMPYPVKKIEVGRTIHHVRYLMNSDVYAVVSSIPKPSNKIWVV-MNDDKQEEIHEKDENFVLPAPPKYTLNLFSSQD---WAAVPNTEISFEDMEAVTACEDVALKSESTISGLETLLAMGTVNNYGEEVLVRGRIILCEVIEVVPEPDQPTSNRKIKVLFDKEQKGPVTGLCAINGLLLCGMGQKVFIWQFKDNDLMGISFLDMHYYVYQLHSLRTIAIACDARESMSLIRFQEDNKAMSIASRDDRKCAQPPMASQLVVDGAHVGFLLSDETGNITMFNYAPEAPESNGGERLTVRAAINIGTNINAFVRLRGHTSLLQLNNEDEKEAIEQ--RMTTVFASLDGSFGFVRPLTEKSYRRLHFLQTFIGSVTPQIAGLHIKGSRSAKPSQPIVNGRNARNLIDGDVVEQYLHLSLYDKTDLARRLGV 1244
[Close]
BLAST of Cleavage and polyadenylation specificity factor subunit 1 vs. Ensembl Celegans
Match: cpsf-1 (Probable cleavage and polyadenylation specificity factor subunit 1 [Source:UniProtKB/Swiss-Prot;Acc:Q9N4C2])

HSP 1 Score: 256.144 bits (653), Expect = 2.917e-74
Identity = 139/441 (31.52%), Postives = 250/441 (56.69%), Query Frame = 2 
Query:   89 EMKLLNLPSGYDYEYQKAVKRISMNRSVHFVQFHIDSKTFAIITSEDREVMSIFKLNAENSKEEEPIERDSDIIRAPLPIYTLEFYANELSGLWEPVPHAKVVFEDWDKVSCMTTVQLFSQMTYSGTKDFLAVGSNMSYGEEIPVRGKIMIVDIIDVVPEPGQVLTRHKMKIIYDVEQKGPVTALTSCKGYLVSAIGQKMYIWELKDNELVGVAFVDSEIYVQQLHCVRNLILTGDFLKSIQLLRFQSDLRVLSLVSKDSH--ARGVTCSNFFVDNENLGFMLADTHANIIIYSYNPLIEESRNGKQLVRNADIKLPITVTCSLRINDRIRDPILYSSSSVTMAQELLRQSVYFGAASGAIFRLSPISNKQLIQMKLTEKNLSQCLHHHGGLLPKSSRQYKFTHPELSNACG-NIADGDLLAQYVTLPYSQRTEIAKKAGV 1402
            E+++  +   +DYE    VK+I + R++H V++ ++S  +A+++S  +    I+ +   + K+EE  E+D + +    P YTL  ++++    W  VP+ ++ FED + V+    V L S+ T SG +  LA+G+  +YGEE+ VRG+I++ ++I+VVPEP Q  +  K+K+++D EQKGPVT L +  G L+  +GQK++IW+ KDN+L+G++F+D   YV QLH +R + +  D  +S+ L+RFQ D + +S+ S+D    A+    S   VD  ++GF+L+D   NI +++Y P   ES  G++L   A I +   +   +R+  R    +L  ++         R +  F +  G+   + P++ K   ++   +  +        GL  K SR  K + P ++     N+ DGD++ QY+ L    +T++A++ GV
Sbjct: 1001 ELRIARMHPDFDYEMPYPVKKIEVGRTIHHVRYLMNSDVYAVVSSIPKPSNKIWVV-MNDDKQEEIHEKDENFVLPAPPKYTLNLFSSQD---WAAVPNTEISFEDMEAVTACEDVALKSESTISGLETLLAMGTVNNYGEEVLVRGRIILCEVIEVVPEPDQPTSNRKIKVLFDKEQKGPVTGLCAINGLLLCGMGQKVFIWQFKDNDLMGISFLDMHYYVYQLHSLRTIAIACDARESMSLIRFQEDNKAMSIASRDDRKCAQPPMASQLVVDGAHVGFLLSDETGNITMFNYAPEAPESNGGERLTVRAAINIGTNINAFVRL--RGHTSLLQLNNEDEKEAIEQRMTTVFASLDGSFGFVRPLTEKSYRRLHFLQTFIGSVTPQIAGLHIKGSRSAKPSQPIVNGRNARNLIDGDVVEQYLHLSLYDKTDLARRLGV 1435
[Close]
BLAST of Cleavage and polyadenylation specificity factor subunit 1 vs. Ensembl Celegans
Match: cpsf-1 (Probable cleavage and polyadenylation specificity factor subunit 1 [Source:UniProtKB/Swiss-Prot;Acc:Q9N4C2])

HSP 1 Score: 202.216 bits (513), Expect = 3.772e-60
Identity = 109/334 (32.63%), Postives = 188/334 (56.29%), Query Frame = 2 
Query:  410 DKVSCMTTVQLFSQMTYSGTKDFLAVGSNMSYGEEIPVRGKIMIVDIIDVVPEPGQVLTRHKMKIIYDVEQKGPVTALTSCKGYLVSAIGQKMYIWELKDNELVGVAFVDSEIYVQQLHCVRNLILTGDFLKSIQLLRFQSDLRVLSLVSKDSH--ARGVTCSNFFVDNENLGFMLADTHANIIIYSYNPLIEESRNGKQLVRNADIKLPITVTCSLRINDRIRDPILYSSSSVTMAQELLRQSVYFGAASGAIFRLSPISNKQLIQMKLTEKNLSQCLHHHGGLLPKSSRQYKFTHPELSNACG-NIADGDLLAQYVTLPYSQRTEIAKKAGV 1402
            + V+    V L S+ T SG +  LA+G+  +YGEE+ VRG+I++ ++I+VVPEP Q  +  K+K+++D EQKGPVT L +  G L+  +GQK++IW+ KDN+L+G++F+D   YV QLH +R + +  D  +S+ L+RFQ D + +S+ S+D    A+    S   VD  ++GF+L+D   NI +++Y P   ES  G++L   A I +   +   +R+        L +       ++  R +  F +  G+   + P++ K   ++   +  +        GL  K SR  K + P ++     N+ DGD++ QY+ L    +T++A++ GV
Sbjct:    2 EAVTACEDVALKSESTISGLETLLAMGTVNNYGEEVLVRGRIILCEVIEVVPEPDQPTSNRKIKVLFDKEQKGPVTGLCAINGLLLCGMGQKVFIWQFKDNDLMGISFLDMHYYVYQLHSLRTIAIACDARESMSLIRFQEDNKAMSIASRDDRKCAQPPMASQLVVDGAHVGFLLSDETGNITMFNYAPEAPESNGGERLTVRAAINIGTNINAFVRLRGHTSLLQLNNEDEKEAIEQ--RMTTVFASLDGSFGFVRPLTEKSYRRLHFLQTFIGSVTPQIAGLHIKGSRSAKPSQPIVNGRNARNLIDGDVVEQYLHLSLYDKTDLARRLGV 333
[Close]
BLAST of Cleavage and polyadenylation specificity factor subunit 1 vs. Ensembl Fly
Match: Cpsf160 (gene:FBgn0024698 transcript:FBtr0089257)

HSP 1 Score: 264.618 bits (675), Expect = 3.222e-77
Identity = 159/442 (35.97%), Postives = 239/442 (54.07%), Query Frame = 2 
Query:   89 EMKLLNLPSGYDYEYQKAVKRISMNRSVHFVQFHIDSKTFAIITSEDREVMSIFKLNAENSKEEEPIERDSDIIRAPLPIYTLEFYANELSGLWEPVPHAKVVFEDWDKVSCMTTVQLFSQMTYSGTKDFLAVGSNMSYGEEIPVRGKIMIVDIIDVVPEPGQVLTRHKMKIIYDVEQKGPVTALTSCKGYLVSAIGQKMYIWELKDNELVGVAFVDSEIYVQQLHCVRNLILTGDFLKSIQLLRFQSDLRVLSLVSKDSHARGVTCSNFFVDNENLGFMLADTHANIIIYSYNPLIEESRNGKQLVRNADIKLPITVTCSLRIND-----RIRDPILYSSSSVTMAQELLRQSVYFGAASGAIFRLSPISNKQLIQMKLTEKNLSQCLHHHGGLLPKSSRQYKFTHPELSNACGNIADGDLLAQYVTLPYSQRTEIAKKAG 1399
            E+K+  LPS   Y+    V+++ +  +   + +H +++ + +IT  +  +   ++ N E+ KE     R    I      + +   + E    WE VP A + FE W+ V+    V+L  + T SG K++L +G+N +Y E+I  RG I I DII+VVPEPG+ +T+ K+K I+  EQKGPV+A++   G+LV+ +GQK+YIW+L+D +L+GVAF+D+ IYV Q+  V++LI   D  KSI LLRFQ + R LSL S+D +   V    F VDN NLGF++ D   NII+Y Y P   ES  G++L+R AD  L   V    R+         R P LY +          +  V +G   GA+    P+  K   +  + +  L     H  GL PK  R  K +  +  N    I DGDL+  Y  +  S+R E+AKK G
Sbjct:  973 ELKISVLPSYLSYDSVWPVRKVPLRCTPRQLVYHRENRVYCLITQTEEPMTKYYRFNGED-KELSEESRGERFIYPIGSQFEMVLISPET---WEIVPDASITFEPWEHVTAFKIVKLSYEGTRSGLKEYLCIGTNFNYSEDITSRGNIHIYDIIEVVPEPGKPMTKFKIKEIFKKEQKGPVSAISDVLGFLVTGLGQKIYIWQLRDGDLIGVAFIDTNIYVHQIITVKSLIFIADVYKSISLLRFQEEYRTLSLASRDFNPLEVYGIEFMVDNSNLGFLVTDAERNIIVYMYQPEARESLGGQKLLRKADYHLGQVVNTMFRVQCHQKGLHQRQPFLYEN----------KHFVVYGTLDGALGYCLPLPEKVYRRFLMLQNVLLSYQEHLCGLNPKEYRTLKSSKKQGINPSRCIIDGDLIWSYRLMANSERNEVAKKIG 1400
[Close]
BLAST of Cleavage and polyadenylation specificity factor subunit 1 vs. Ensembl Fly
Match: Cpsf160 (gene:FBgn0024698 transcript:FBtr0089258)

HSP 1 Score: 264.618 bits (675), Expect = 3.698e-77
Identity = 159/442 (35.97%), Postives = 239/442 (54.07%), Query Frame = 2 
Query:   89 EMKLLNLPSGYDYEYQKAVKRISMNRSVHFVQFHIDSKTFAIITSEDREVMSIFKLNAENSKEEEPIERDSDIIRAPLPIYTLEFYANELSGLWEPVPHAKVVFEDWDKVSCMTTVQLFSQMTYSGTKDFLAVGSNMSYGEEIPVRGKIMIVDIIDVVPEPGQVLTRHKMKIIYDVEQKGPVTALTSCKGYLVSAIGQKMYIWELKDNELVGVAFVDSEIYVQQLHCVRNLILTGDFLKSIQLLRFQSDLRVLSLVSKDSHARGVTCSNFFVDNENLGFMLADTHANIIIYSYNPLIEESRNGKQLVRNADIKLPITVTCSLRIND-----RIRDPILYSSSSVTMAQELLRQSVYFGAASGAIFRLSPISNKQLIQMKLTEKNLSQCLHHHGGLLPKSSRQYKFTHPELSNACGNIADGDLLAQYVTLPYSQRTEIAKKAG 1399
            E+K+  LPS   Y+    V+++ +  +   + +H +++ + +IT  +  +   ++ N E+ KE     R    I      + +   + E    WE VP A + FE W+ V+    V+L  + T SG K++L +G+N +Y E+I  RG I I DII+VVPEPG+ +T+ K+K I+  EQKGPV+A++   G+LV+ +GQK+YIW+L+D +L+GVAF+D+ IYV Q+  V++LI   D  KSI LLRFQ + R LSL S+D +   V    F VDN NLGF++ D   NII+Y Y P   ES  G++L+R AD  L   V    R+         R P LY +          +  V +G   GA+    P+  K   +  + +  L     H  GL PK  R  K +  +  N    I DGDL+  Y  +  S+R E+AKK G
Sbjct: 1008 ELKISVLPSYLSYDSVWPVRKVPLRCTPRQLVYHRENRVYCLITQTEEPMTKYYRFNGED-KELSEESRGERFIYPIGSQFEMVLISPET---WEIVPDASITFEPWEHVTAFKIVKLSYEGTRSGLKEYLCIGTNFNYSEDITSRGNIHIYDIIEVVPEPGKPMTKFKIKEIFKKEQKGPVSAISDVLGFLVTGLGQKIYIWQLRDGDLIGVAFIDTNIYVHQIITVKSLIFIADVYKSISLLRFQEEYRTLSLASRDFNPLEVYGIEFMVDNSNLGFLVTDAERNIIVYMYQPEARESLGGQKLLRKADYHLGQVVNTMFRVQCHQKGLHQRQPFLYEN----------KHFVVYGTLDGALGYCLPLPEKVYRRFLMLQNVLLSYQEHLCGLNPKEYRTLKSSKKQGINPSRCIIDGDLIWSYRLMANSERNEVAKKIG 1435
[Close]
BLAST of Cleavage and polyadenylation specificity factor subunit 1 vs. Ensembl Zebrafish
Match: cpsf1 (cleavage and polyadenylation specific factor 1 [Source:ZFIN;Acc:ZDB-GENE-040709-2])

HSP 1 Score: 328.946 bits (842), Expect = 1.012e-99
Identity = 170/438 (38.81%), Postives = 267/438 (60.96%), Query Frame = 2 
Query:   86 GEMKLLNLPSGYDYEYQKAVKRISMNRSVHFVQFHIDSKTFAIITSEDREVMSIFKLNAENSKEEEPIERDSDIIRAPLPIYTLEFYANELSGLWEPVPHAKVVFEDWDKVSCMTTVQLFSQMTYSGTKDFLAVGSNMSYGEEIPVRGKIMIVDIIDVVPEPGQVLTRHKMKIIYDVEQKGPVTALTSCKGYLVSAIGQKMYIWELKDNELVGVAFVDSEIYVQQLHCVRNLILTGDFLKSIQLLRFQSDLRVLSLVSKDSHARGVTCSNFFVDNENLGFMLADTHANIIIYSYNPLIEESRNGKQLVRNADIKLPITVTCSLRINDRIRDPILYSSSSVTMAQELLRQSVYFGAASGAIFRLSPISNKQLIQMKLTEKNLSQCLHHHGGLLPKSSRQYKFTHPELSNACGNIADGDLLAQYVTLPYSQRTEIAKKAG 1399
            GE+++  LP+   Y+    V++I +  +VH+V +H++SK +A+ TS       I ++  E  KE E IERD   I      ++++  +      WE +P+ +V  E+W+ V+CM TV L SQ T SG K ++A+G+ +  GEE+  RG+I+I+D+I+VVPEPGQ LT++K K++Y+ EQKGPVTAL  C G+LVSAIGQK+++W LKDN+L G+AF+D+++Y+ Q++ ++N IL  D +KSI LLR+Q + + LSLVS+D+    V    F VDN  LGF+++D   N+++Y Y P  +ES  G +L+R AD  +   V    R+  R     L +++   +  +  +   +F    G +  L P+  K   ++ + +  L+  L HH GL PK+ R        L NA  NI DG+LL +Y+ L   +R+E+AKK G
Sbjct:  999 GELRISVLPTYLSYDAPWPVRKIPLRCTVHYVSYHVESKVYAVCTSVKEPCTRIPRMTGEE-KEFETIERDERYIHPQQDKFSIQLIS---PVSWEAIPNTRVDLEEWEHVTCMKTVALKSQETVSGLKGYVALGTCLMQGEEVTCRGRILILDVIEVVPEPGQPLTKNKFKVLYEKEQKGPVTALCHCSGFLVSAIGQKIFLWSLKDNDLTGMAFIDTQLYIHQMYSIKNFILAADVMKSISLLRYQPESKTLSLVSRDAKPLEVYSIEFMVDNNQLGFLVSDRDKNLMVYMYLPEAKESFGGMRLLRRADFNVGSHVNAFWRMPCR---GTLDTANKKALTWD-NKHITWFATLDGGVGLLLPMQEKTYRRLLMLQNALTTMLPHHAGLNPKAFRMLHCDRRTLQNAVKNILDGELLNKYLYLSTMERSELAKKIG 1428
[Close]
BLAST of Cleavage and polyadenylation specificity factor subunit 1 vs. Ensembl Zebrafish
Match: cpsf1 (cleavage and polyadenylation specific factor 1 [Source:ZFIN;Acc:ZDB-GENE-040709-2])

HSP 1 Score: 328.946 bits (842), Expect = 1.271e-99
Identity = 170/438 (38.81%), Postives = 267/438 (60.96%), Query Frame = 2 
Query:   86 GEMKLLNLPSGYDYEYQKAVKRISMNRSVHFVQFHIDSKTFAIITSEDREVMSIFKLNAENSKEEEPIERDSDIIRAPLPIYTLEFYANELSGLWEPVPHAKVVFEDWDKVSCMTTVQLFSQMTYSGTKDFLAVGSNMSYGEEIPVRGKIMIVDIIDVVPEPGQVLTRHKMKIIYDVEQKGPVTALTSCKGYLVSAIGQKMYIWELKDNELVGVAFVDSEIYVQQLHCVRNLILTGDFLKSIQLLRFQSDLRVLSLVSKDSHARGVTCSNFFVDNENLGFMLADTHANIIIYSYNPLIEESRNGKQLVRNADIKLPITVTCSLRINDRIRDPILYSSSSVTMAQELLRQSVYFGAASGAIFRLSPISNKQLIQMKLTEKNLSQCLHHHGGLLPKSSRQYKFTHPELSNACGNIADGDLLAQYVTLPYSQRTEIAKKAG 1399
            GE+++  LP+   Y+    V++I +  +VH+V +H++SK +A+ TS       I ++  E  KE E IERD   I      ++++  +      WE +P+ +V  E+W+ V+CM TV L SQ T SG K ++A+G+ +  GEE+  RG+I+I+D+I+VVPEPGQ LT++K K++Y+ EQKGPVTAL  C G+LVSAIGQK+++W LKDN+L G+AF+D+++Y+ Q++ ++N IL  D +KSI LLR+Q + + LSLVS+D+    V    F VDN  LGF+++D   N+++Y Y P  +ES  G +L+R AD  +   V    R+  R     L +++   +  +  +   +F    G +  L P+  K   ++ + +  L+  L HH GL PK+ R        L NA  NI DG+LL +Y+ L   +R+E+AKK G
Sbjct: 1002 GELRISVLPTYLSYDAPWPVRKIPLRCTVHYVSYHVESKVYAVCTSVKEPCTRIPRMTGEE-KEFETIERDERYIHPQQDKFSIQLIS---PVSWEAIPNTRVDLEEWEHVTCMKTVALKSQETVSGLKGYVALGTCLMQGEEVTCRGRILILDVIEVVPEPGQPLTKNKFKVLYEKEQKGPVTALCHCSGFLVSAIGQKIFLWSLKDNDLTGMAFIDTQLYIHQMYSIKNFILAADVMKSISLLRYQPESKTLSLVSRDAKPLEVYSIEFMVDNNQLGFLVSDRDKNLMVYMYLPEAKESFGGMRLLRRADFNVGSHVNAFWRMPCR---GTLDTANKKALTWD-NKHITWFATLDGGVGLLLPMQEKTYRRLLMLQNALTTMLPHHAGLNPKAFRMLHCDRRTLQNAVKNILDGELLNKYLYLSTMERSELAKKIG 1431
[Close]
BLAST of Cleavage and polyadenylation specificity factor subunit 1 vs. Ensembl Xenopus
Match: hnmt (histamine N-methyltransferase [Source:Xenbase;Acc:XB-GENE-1001069])

HSP 1 Score: 105.916 bits (263), Expect = 1.131e-25
Identity = 66/207 (31.88%), Postives = 103/207 (49.76%), Query Frame = 2 
Query:  800 LKSIQLLRFQSDLRVLSLVSKDSHARGVTCSNFFVDNENLGFMLADTHANIIIYSYNPLIEESRNGKQLVRNADIKLPITVTCSLRINDR------IRDPILYSSSSVTMAQELLRQSVYFGAASGAIFRLSPISNKQLIQMKLTEKNLSQCLHHHGGLLPKSSRQYKFTHPELSNACGNIADGDLLAQYVTLPYSQRTEIAKKAGV 1402
            +KSI LLR+Q + + LSLVS+D     V    F VDN  LGF+++D   N+I+Y Y P  +ES  G +L+R AD      +    R   R       R  +L+ +  +T          +F    G +  L P+  K   ++ + +  L+  L HH GL P++ R    +   L N   N+ DG+LL +Y+ L   +R+E+A+K G 
Sbjct:    1 MKSISLLRYQEESKTLSLVSRDVKPLEVYSVEFLVDNNQLGFLVSDRDRNLILYMYLPAAKESFGGMRLLRRADFHAGSNINSFWRTPCRGGSEGPSRKAVLWDNKHIT----------WFATLDGGVGLLLPMQEKTYRRLLMLQNALT-VLPHHAGLNPRAFRMLNSSRRMLQNPVRNVLDGELLNRYLYLSNMERSELARKIGT 196
[Close]
BLAST of Cleavage and polyadenylation specificity factor subunit 1 vs. Ensembl Xenopus
Match: hnmt (histamine N-methyltransferase [Source:Xenbase;Acc:XB-GENE-1001069])

HSP 1 Score: 79.337 bits (194), Expect = 1.854e-16
Identity = 59/207 (28.50%), Postives = 95/207 (45.89%), Query Frame = 2 
Query:  800 LKSIQLLRFQSDLRVLSLVSKDSHARGVTCSNFFVDNENLGFMLADTHANIIIYSYNPLIEESRNGKQLVRNADIKLPITVTCSLRINDR------IRDPILYSSSSVTMAQELLRQSVYFGAASGAIFRLSPISNKQLIQMKLTEKNLSQCLHHHGGLLPKSSRQYKFTHPELSNACGNIADGDLLAQYVTLPYSQRTEIAKKAGV 1402
            +KSI LLR+Q + + LSLVS+ S       S            ++D   N+I+Y Y P  +ES  G +L+R AD      +    R   R       R  +L+ +  +T          +F    G +  L P+  K   ++ + +  L+  L HH GL P++ R    +   L N   N+ DG+LL +Y+ L   +R+E+A+K G 
Sbjct:    1 MKSISLLRYQEESKTLSLVSRGSLILMFCLS------------VSDRDRNLILYMYLPAAKESFGGMRLLRRADFHAGSNINSFWRTPCRGGSEGPSRKAVLWDNKHIT----------WFATLDGGVGLLLPMQEKTYRRLLMLQNALT-VLPHHAGLNPRAFRMLNSSRRMLQNPVRNVLDGELLNRYLYLSNMERSELARKIGT 184
[Close]
BLAST of Cleavage and polyadenylation specificity factor subunit 1 vs. Ensembl Mouse
Match: Cpsf1 (cleavage and polyadenylation specific factor 1 [Source:MGI Symbol;Acc:MGI:2679722])

HSP 1 Score: 321.627 bits (823), Expect = 4.809e-97
Identity = 165/441 (37.41%), Postives = 264/441 (59.86%), Query Frame = 2 
Query:   86 GEMKLLNLPSGYDYEYQKAVKRISMNRSVHFVQFHIDSKTFAIITSEDREVMSIFKLNAENSKEEEPIERDSDIIRAPLPIYTLEFYANELSGLWEPVPHAKVVFEDWDKVSCMTTVQLFSQMTYSGTKDFLAVGSNMSYGEEIPVRGKIMIVDIIDVVPEPGQVLTRHKMKIIYDVEQKGPVTALTSCKGYLVSAIGQKMYIWELKDNELVGVAFVDSEIYVQQLHCVRNLILTGDFLKSIQLLRFQSDLRVLSLVSKDSHARGVTCSNFFVDNENLGFMLADTHANIIIYSYNPLIEESRNGKQLVRNADIKLPITVTCSLRINDRIRDPILYSSSSVTMAQELL--RQSVYFGAASGAIFRLSPISNKQLIQMKLTEKNLSQCLHHHGGLLPKSSRQYKFTHPELSNACGNIADGDLLAQYVTLPYSQRTEIAKKAGV 1402
            GE+++  LP+   Y+    V++I +  + H+V +H++SK +A+ TS +     I ++  E  KE E IERD   I      ++++  +      WE +P+A++  E+W+ V+CM TV L S+ T SG K ++A G+ +  GEE+  RG+I+I+D+I+VVPEPGQ LT++K K++Y+ EQKGPVTAL  C G+LVSAIGQK+++W L+ +EL G+AF+D+++Y+ Q+  V+N IL  D +KSI LLR+Q + + LSLVS+D+    V   +F VDN  LGF+++D   N+++Y Y P  +ES  G +L+R AD  +         +N   R P   ++   +    +   +   +F    G I  L P+  K   ++ + +  L+  L HH GL P++ R        L NA  N+ DG+LL +Y+ L   +R+E+AKK G 
Sbjct:  992 GELRISVLPAYLSYDAPWPVRKIPLRCTAHYVAYHVESKVYAVATSTNTPCTRIPRMTGEE-KEFEAIERDDRYIHPQQEAFSIQLIS---PVSWEAIPNARIELEEWEHVTCMKTVSLRSEETVSGLKGYVAAGTCLMQGEEVTCRGRILIMDVIEVVPEPGQPLTKNKFKVLYEKEQKGPVTALCHCNGHLVSAIGQKIFLWSLRASELTGMAFIDTQLYIHQMISVKNFILAADVMKSISLLRYQEESKTLSLVSRDAKPLEVYSVDFMVDNAQLGFLVSDRDRNLMVYMYLPEAKESFGGMRLLRRADFHV------GAHVNTFWRTPCRGAAEGPSKKSVVWENKHITWFATLDGGIGLLLPMQEKTYRRLLMLQNALTTMLPHHAGLNPRAFRMLHVDRRILQNAVRNVLDGELLNRYLYLSTMERSELAKKIGT 1422
[Close]
BLAST of Cleavage and polyadenylation specificity factor subunit 1 vs. Ensembl Mouse
Match: Cpsf1 (cleavage and polyadenylation specific factor 1 [Source:MGI Symbol;Acc:MGI:2679722])

HSP 1 Score: 321.242 bits (822), Expect = 5.928e-97
Identity = 165/441 (37.41%), Postives = 264/441 (59.86%), Query Frame = 2 
Query:   86 GEMKLLNLPSGYDYEYQKAVKRISMNRSVHFVQFHIDSKTFAIITSEDREVMSIFKLNAENSKEEEPIERDSDIIRAPLPIYTLEFYANELSGLWEPVPHAKVVFEDWDKVSCMTTVQLFSQMTYSGTKDFLAVGSNMSYGEEIPVRGKIMIVDIIDVVPEPGQVLTRHKMKIIYDVEQKGPVTALTSCKGYLVSAIGQKMYIWELKDNELVGVAFVDSEIYVQQLHCVRNLILTGDFLKSIQLLRFQSDLRVLSLVSKDSHARGVTCSNFFVDNENLGFMLADTHANIIIYSYNPLIEESRNGKQLVRNADIKLPITVTCSLRINDRIRDPILYSSSSVTMAQELL--RQSVYFGAASGAIFRLSPISNKQLIQMKLTEKNLSQCLHHHGGLLPKSSRQYKFTHPELSNACGNIADGDLLAQYVTLPYSQRTEIAKKAGV 1402
            GE+++  LP+   Y+    V++I +  + H+V +H++SK +A+ TS +     I ++  E  KE E IERD   I      ++++  +      WE +P+A++  E+W+ V+CM TV L S+ T SG K ++A G+ +  GEE+  RG+I+I+D+I+VVPEPGQ LT++K K++Y+ EQKGPVTAL  C G+LVSAIGQK+++W L+ +EL G+AF+D+++Y+ Q+  V+N IL  D +KSI LLR+Q + + LSLVS+D+    V   +F VDN  LGF+++D   N+++Y Y P  +ES  G +L+R AD  +         +N   R P   ++   +    +   +   +F    G I  L P+  K   ++ + +  L+  L HH GL P++ R        L NA  N+ DG+LL +Y+ L   +R+E+AKK G 
Sbjct:  992 GELRISVLPAYLSYDAPWPVRKIPLRCTAHYVAYHVESKVYAVATSTNTPCTRIPRMTGEE-KEFEAIERDDRYIHPQQEAFSIQLIS---PVSWEAIPNARIELEEWEHVTCMKTVSLRSEETVSGLKGYVAAGTCLMQGEEVTCRGRILIMDVIEVVPEPGQPLTKNKFKVLYEKEQKGPVTALCHCNGHLVSAIGQKIFLWSLRASELTGMAFIDTQLYIHQMISVKNFILAADVMKSISLLRYQEESKTLSLVSRDAKPLEVYSVDFMVDNAQLGFLVSDRDRNLMVYMYLPEAKESFGGMRLLRRADFHV------GAHVNTFWRTPCRGAAEGPSKKSVVWENKHITWFATLDGGIGLLLPMQEKTYRRLLMLQNALTTMLPHHAGLNPRAFRMLHVDRRILQNAVRNVLDGELLNRYLYLSTMERSELAKKIGT 1422
[Close]
BLAST of Cleavage and polyadenylation specificity factor subunit 1 vs. Ensembl Mouse
Match: Cpsf1 (cleavage and polyadenylation specific factor 1 [Source:MGI Symbol;Acc:MGI:2679722])

HSP 1 Score: 55.4546 bits (132), Expect = 5.141e-9
Identity = 29/83 (34.94%), Postives = 44/83 (53.01%), Query Frame = 2 
Query: 1154 SGAIFRLSPISNKQLIQMKLTEKNLSQCLHHHGGLLPKSSRQYKFTHPELSNACGNIADGDLLAQYVTLPYSQRTEIAKKAGV 1402
             G I  L P+  K   ++ + +  L+  L HH GL P++ R        L NA  N+ DG+LL +Y+ L   +R+E+AKK G 
Sbjct:   20 DGGIGLLLPMQEKTYRRLLMLQNALTTMLPHHAGLNPRAFRMLHVDRRILQNAVRNVLDGELLNRYLYLSTMERSELAKKIGT 102
[Close]
BLAST of Cleavage and polyadenylation specificity factor subunit 1 vs. UniProt/SwissProt
Match: sp|Q10570|CPSF1_HUMAN (Cleavage and polyadenylation specificity factor subunit 1 OS=Homo sapiens OX=9606 GN=CPSF1 PE=1 SV=2)

HSP 1 Score: 322.783 bits (826), Expect = 1.179e-96
Identity = 167/439 (38.04%), Postives = 263/439 (59.91%), Query Frame = 2 
Query:   86 GEMKLLNLPSGYDYEYQKAVKRISMNRSVHFVQFHIDSKTFAIITSEDREVMSIFKLNAENSKEEEPIERDSDIIRAPLPIYTLEFYANELSGLWEPVPHAKVVFEDWDKVSCMTTVQLFSQMTYSGTKDFLAVGSNMSYGEEIPVRGKIMIVDIIDVVPEPGQVLTRHKMKIIYDVEQKGPVTALTSCKGYLVSAIGQKMYIWELKDNELVGVAFVDSEIYVQQLHCVRNLILTGDFLKSIQLLRFQSDLRVLSLVSKDSHARGVTCSNFFVDNENLGFMLADTHANIIIYSYNPLIEESRNGKQLVRNADIKLPITVTCSLRINDRIRDPILYSSSSVTMAQELLRQSVYFGAASGAIFRLSPISNKQLIQMKLTEKNLSQCLHHHGGLLPKSSRQYKFTHPELSNACGNIADGDLLAQYVTLPYSQRTEIAKKAGV 1402
            GE+++  LP+   Y+    V++I +  + H+V +H++SK +A+ TS +     I ++  E  KE E IERD   I      ++++  +      WE +P+A++  ++W+ V+CM TV L S+ T SG K ++A G+ +  GEE+  RG+I+I+D+I+VVPEPGQ LT++K K++Y+ EQKGPVTAL  C G+LVSAIGQK+++W L+ +EL G+AF+D+++Y+ Q+  V+N IL  D +KSI LLR+Q + + LSLVS+D+    V   +F VDN  LGF+++D   N+++Y Y P  +ES  G +L+R AD  +   V    R   R     L   S V   + +     +F    G I  L P+  K   ++ + +  L+  L HH GL P++ R        L NA  N+ DG+LL +Y+ L   +R+E+AKK G 
Sbjct:  994 GELRISVLPAYLSYDAPWPVRKIPLRCTAHYVAYHVESKVYAVATSTNTPCARIPRMTGEE-KEFETIERDERYIHPQQEAFSIQLIS---PVSWEAIPNARIELQEWEHVTCMKTVSLRSEETVSGLKGYVAAGTCLMQGEEVTCRGRILIMDVIEVVPEPGQPLTKNKFKVLYEKEQKGPVTALCHCNGHLVSAIGQKIFLWSLRASELTGMAFIDTQLYIHQMISVKNFILAADVMKSISLLRYQEESKTLSLVSRDAKPLEVYSVDFMVDNAQLGFLVSDRDRNLMVYMYLPEAKESFGGMRLLRRADFHVGAHVNTFWRTPCRGATEGLSKKSVVWENKHI----TWFATLDGGIGLLLPMQEKTYRRLLMLQNALTTMLPHHAGLNPRAFRMLHVDRRTLQNAVRNVLDGELLNRYLYLSTMERSELAKKIGT 1424
[Close]
BLAST of Cleavage and polyadenylation specificity factor subunit 1 vs. UniProt/SwissProt
Match: sp|Q9EPU4|CPSF1_MOUSE (Cleavage and polyadenylation specificity factor subunit 1 OS=Mus musculus OX=10090 GN=Cpsf1 PE=1 SV=1)

HSP 1 Score: 321.627 bits (823), Expect = 3.364e-96
Identity = 165/441 (37.41%), Postives = 264/441 (59.86%), Query Frame = 2 
Query:   86 GEMKLLNLPSGYDYEYQKAVKRISMNRSVHFVQFHIDSKTFAIITSEDREVMSIFKLNAENSKEEEPIERDSDIIRAPLPIYTLEFYANELSGLWEPVPHAKVVFEDWDKVSCMTTVQLFSQMTYSGTKDFLAVGSNMSYGEEIPVRGKIMIVDIIDVVPEPGQVLTRHKMKIIYDVEQKGPVTALTSCKGYLVSAIGQKMYIWELKDNELVGVAFVDSEIYVQQLHCVRNLILTGDFLKSIQLLRFQSDLRVLSLVSKDSHARGVTCSNFFVDNENLGFMLADTHANIIIYSYNPLIEESRNGKQLVRNADIKLPITVTCSLRINDRIRDPILYSSSSVTMAQELL--RQSVYFGAASGAIFRLSPISNKQLIQMKLTEKNLSQCLHHHGGLLPKSSRQYKFTHPELSNACGNIADGDLLAQYVTLPYSQRTEIAKKAGV 1402
            GE+++  LP+   Y+    V++I +  + H+V +H++SK +A+ TS +     I ++  E  KE E IERD   I      ++++  +      WE +P+A++  E+W+ V+CM TV L S+ T SG K ++A G+ +  GEE+  RG+I+I+D+I+VVPEPGQ LT++K K++Y+ EQKGPVTAL  C G+LVSAIGQK+++W L+ +EL G+AF+D+++Y+ Q+  V+N IL  D +KSI LLR+Q + + LSLVS+D+    V   +F VDN  LGF+++D   N+++Y Y P  +ES  G +L+R AD  +         +N   R P   ++   +    +   +   +F    G I  L P+  K   ++ + +  L+  L HH GL P++ R        L NA  N+ DG+LL +Y+ L   +R+E+AKK G 
Sbjct:  992 GELRISVLPAYLSYDAPWPVRKIPLRCTAHYVAYHVESKVYAVATSTNTPCTRIPRMTGEE-KEFEAIERDDRYIHPQQEAFSIQLIS---PVSWEAIPNARIELEEWEHVTCMKTVSLRSEETVSGLKGYVAAGTCLMQGEEVTCRGRILIMDVIEVVPEPGQPLTKNKFKVLYEKEQKGPVTALCHCNGHLVSAIGQKIFLWSLRASELTGMAFIDTQLYIHQMISVKNFILAADVMKSISLLRYQEESKTLSLVSRDAKPLEVYSVDFMVDNAQLGFLVSDRDRNLMVYMYLPEAKESFGGMRLLRRADFHV------GAHVNTFWRTPCRGAAEGPSKKSVVWENKHITWFATLDGGIGLLLPMQEKTYRRLLMLQNALTTMLPHHAGLNPRAFRMLHVDRRILQNAVRNVLDGELLNRYLYLSTMERSELAKKIGT 1422
[Close]
BLAST of Cleavage and polyadenylation specificity factor subunit 1 vs. UniProt/SwissProt
Match: sp|Q10569|CPSF1_BOVIN (Cleavage and polyadenylation specificity factor subunit 1 OS=Bos taurus OX=9913 GN=CPSF1 PE=1 SV=1)

HSP 1 Score: 318.161 bits (814), Expect = 6.454e-95
Identity = 163/441 (36.96%), Postives = 261/441 (59.18%), Query Frame = 2 
Query:   86 GEMKLLNLPSGYDYEYQKAVKRISMNRSVHFVQFHIDSKTFAIITSEDREVMSIFKLNAENSKEEEPIERDSDIIRAPLPIYTLEFYANELSGLWEPVPHAKVVFEDWDKVSCMTTVQLFSQMTYSGTKDFLAVGSNMSYGEEIPVRGKIMIVDIIDVVPEPGQVLTRHKMKIIYDVEQKGPVTALTSCKGYLVSAIGQKMYIWELKDNELVGVAFVDSEIYVQQLHCVRNLILTGDFLKSIQLLRFQSDLRVLSLVSKDSHARGVTCSNFFVDNENLGFMLADTHANIIIYSYNPLIEESRNGKQLVRNADIKLPITVTCSLRINDRIRDPILYSSSSVTMAQELL--RQSVYFGAASGAIFRLSPISNKQLIQMKLTEKNLSQCLHHHGGLLPKSSRQYKFTHPELSNACGNIADGDLLAQYVTLPYSQRTEIAKKAGV 1402
            GE+++  LP+   Y+    V++I +  + H+V +H++SK +A+ TS       + ++  E  KE E IERD   +      + ++  +      WE +P+A++  E+W+ V+CM TV L S+ T SG K ++A G+ +  GEE+  RG+I+I+D+I+VVPEPGQ LT++K K++Y+ EQKGPVTAL  C G+LVSAIGQK+++W L+ +EL G+AF+D+++Y+ Q+  V+N IL  D +KSI LLR+Q + + LSLVS+D+    V   +F VDN  LGF+++D   N+++Y Y P  +ES  G +L+R AD  +         +N   R P   ++   +    +   +   +F    G I  L P+  K   ++ + +  L+  L HH GL P++ R        L NA  N+ DG+LL +Y+ L   +R E+AKK G 
Sbjct:  995 GELRISVLPAYLSYDAPWPVRKIPLRCTAHYVAYHVESKVYAVATSTSTPCTRVPRMTGEE-KEFETIERDERYVHPQQEAFCIQLIS---PVSWEAIPNARIELEEWEHVTCMKTVSLRSEETVSGLKGYVAAGTCLMQGEEVTCRGRILIMDVIEVVPEPGQPLTKNKFKVLYEKEQKGPVTALCHCNGHLVSAIGQKIFLWSLRASELTGMAFIDTQLYIHQMISVKNFILAADVMKSISLLRYQEESKTLSLVSRDAKPLEVYSVDFMVDNAQLGFLVSDRDRNLMVYMYLPEAKESFGGMRLLRRADFHV------GAHVNTFWRTPCRGAAEGPSKKSVVWENKHITWFATLDGGIGLLLPMQEKTYRRLLMLQNALTTMLPHHAGLNPRAFRMLHVDRRVLQNAVRNVLDGELLNRYLYLSTMERGELAKKIGT 1425
[Close]
BLAST of Cleavage and polyadenylation specificity factor subunit 1 vs. UniProt/SwissProt
Match: sp|A8XPU7|CPSF1_CAEBR (Probable cleavage and polyadenylation specificity factor subunit 1 OS=Caenorhabditis briggsae OX=6238 GN=cpsf-1 PE=3 SV=1)

HSP 1 Score: 273.478 bits (698), Expect = 3.147e-79
Identity = 146/441 (33.11%), Postives = 254/441 (57.60%), Query Frame = 2 
Query:   89 EMKLLNLPSGYDYEYQKAVKRISMNRSVHFVQFHIDSKTFAIITSEDREVMSIFKLNAENSKEEEPIERDSDIIRAPLPIYTLEFYANELSGLWEPVPHAKVVFEDWDKVSCMTTVQLFSQMTYSGTKDFLAVGSNMSYGEEIPVRGKIMIVDIIDVVPEPGQVLTRHKMKIIYDVEQKGPVTALTSCKGYLVSAIGQKMYIWELKDNELVGVAFVDSEIYVQQLHCVRNLILTGDFLKSIQLLRFQSDLRVLSLVSKDSH--ARGVTCSNFFVDNENLGFMLADTHANIIIYSYNPLIEESRNGKQLVRNADIKLPITVTCSLRINDRIRDPILYSSSSVTMAQELLRQSVYFGAASGAIFRLSPISNKQLIQMKLTEKNLSQCLHHHGGLLPKSSRQYKFTHPELSNACG-NIADGDLLAQYVTLPYSQRTEIAKKAGV 1402
            E+++  +   +DY+    VK+I + ++VH V++ ++S  +A+++S  +    I+ +   + K+EE  E+D + +    P YTL  ++++    W  VP+ +  FED + V+ M  V L S+  Y G   +LA+ +  +YGEE+ VRG+I++ ++I+VVPEPGQ  +  K+K++YD EQKGPVT L +  G L+S +GQK++IW+ KDN+L+G++F+D   YV QLH +R + L  D  +S+ L+RFQ + + +S+ S+D    A+    S F VD  ++GF+L+D H NI ++SY+P   ES  G++L   A I +   +   LR+       +L SSS         R +  FG+  G+   + P++ K   ++   +  +        GL  K +R  K + P ++     N+ DGD++ QY+ L    +T++A++ GV
Sbjct: 1001 ELRIARMHPDFDYDMPYPVKKIEVGKTVHNVRYLMNSDIYAVVSSVPKPSNKIWVV-MNDDKQEEIHEKDENFVLPAPPKYTLNLFSSQD---WAAVPNTEFEFEDMEAVTAMEDVPLKSESRYGGLDTYLALATVNNYGEEVLVRGRIILCEVIEVVPEPGQPTSNRKIKVLYDKEQKGPVTGLCAINGLLLSGMGQKVFIWQFKDNDLMGISFLDMHYYVYQLHSIRTIALALDARESMSLIRFQEENKAMSIASRDDRKCAQAPMASEFLVDGMHIGFLLSDEHGNITLFSYSPEAPESNGGERLTVKAAINIGTNINAFLRVKGHTS--LLDSSSPEERENIEQRMNTIFGSLDGSFGYIRPLTEKSYRRLHFLQTFIGSVTPQIAGLHIKGARSSKPSQPIVNGRNARNLIDGDVVEQYLHLSVYDKTDLARRLGV 1435
[Close]
BLAST of Cleavage and polyadenylation specificity factor subunit 1 vs. UniProt/SwissProt
Match: sp|Q9V726|CPSF1_DROME (Cleavage and polyadenylation specificity factor subunit 1 OS=Drosophila melanogaster OX=7227 GN=Cpsf160 PE=1 SV=1)

HSP 1 Score: 264.618 bits (675), Expect = 3.707e-76
Identity = 159/442 (35.97%), Postives = 239/442 (54.07%), Query Frame = 2 
Query:   89 EMKLLNLPSGYDYEYQKAVKRISMNRSVHFVQFHIDSKTFAIITSEDREVMSIFKLNAENSKEEEPIERDSDIIRAPLPIYTLEFYANELSGLWEPVPHAKVVFEDWDKVSCMTTVQLFSQMTYSGTKDFLAVGSNMSYGEEIPVRGKIMIVDIIDVVPEPGQVLTRHKMKIIYDVEQKGPVTALTSCKGYLVSAIGQKMYIWELKDNELVGVAFVDSEIYVQQLHCVRNLILTGDFLKSIQLLRFQSDLRVLSLVSKDSHARGVTCSNFFVDNENLGFMLADTHANIIIYSYNPLIEESRNGKQLVRNADIKLPITVTCSLRIND-----RIRDPILYSSSSVTMAQELLRQSVYFGAASGAIFRLSPISNKQLIQMKLTEKNLSQCLHHHGGLLPKSSRQYKFTHPELSNACGNIADGDLLAQYVTLPYSQRTEIAKKAG 1399
            E+K+  LPS   Y+    V+++ +  +   + +H +++ + +IT  +  +   ++ N E+ KE     R    I      + +   + E    WE VP A + FE W+ V+    V+L  + T SG K++L +G+N +Y E+I  RG I I DII+VVPEPG+ +T+ K+K I+  EQKGPV+A++   G+LV+ +GQK+YIW+L+D +L+GVAF+D+ IYV Q+  V++LI   D  KSI LLRFQ + R LSL S+D +   V    F VDN NLGF++ D   NII+Y Y P   ES  G++L+R AD  L   V    R+         R P LY +          +  V +G   GA+    P+  K   +  + +  L     H  GL PK  R  K +  +  N    I DGDL+  Y  +  S+R E+AKK G
Sbjct: 1008 ELKISVLPSYLSYDSVWPVRKVPLRCTPRQLVYHRENRVYCLITQTEEPMTKYYRFNGED-KELSEESRGERFIYPIGSQFEMVLISPET---WEIVPDASITFEPWEHVTAFKIVKLSYEGTRSGLKEYLCIGTNFNYSEDITSRGNIHIYDIIEVVPEPGKPMTKFKIKEIFKKEQKGPVSAISDVLGFLVTGLGQKIYIWQLRDGDLIGVAFIDTNIYVHQIITVKSLIFIADVYKSISLLRFQEEYRTLSLASRDFNPLEVYGIEFMVDNSNLGFLVTDAERNIIVYMYQPEARESLGGQKLLRKADYHLGQVVNTMFRVQCHQKGLHQRQPFLYEN----------KHFVVYGTLDGALGYCLPLPEKVYRRFLMLQNVLLSYQEHLCGLNPKEYRTLKSSKKQGINPSRCIIDGDLIWSYRLMANSERNEVAKKIG 1435
[Close]
BLAST of Cleavage and polyadenylation specificity factor subunit 1 vs. TrEMBL
Match: A0A5J4NP06 (Cleavage and polyadenylation specificity factor subunit 1 OS=Paragonimus westermani OX=34504 GN=DEA37_0000479 PE=4 SV=1)

HSP 1 Score: 481.1 bits (1237), Expect = 2.221e-150
Identity = 234/489 (47.85%), Postives = 326/489 (66.67%), Query Frame = 2 
Query:   89 EMKLLNLPSGYDYEYQKAVKRISMNRSVHFVQFHIDSKTFAIITSEDREVMSIFKLNAENSKEEEPIERDSDIIRAPLPIYTLEFYANEL----SGLWEPVPHAKVVFEDWDKVSCMTTVQLFSQMTYSGTKDFLAVGSNMSYGEEIPVRGKIMIVDIIDVVPEPGQVLTRHKMKIIYDVEQKGPVTALTSCKGYLVSAIGQKMYIWELKDNELVGVAFVDSEIYVQQLHCVRNLILTGDFLKSIQLLRFQSDLRVLSLVSKDSHARGVTCSNFFVDNENLGFMLADTHANIIIYSYNPLIEESRNGKQLVRNADIKLPITVTCSLRINDRIR-------------DPILYSSSSVTMAQ--------------------------------ELLRQSVYFGAASGAIFRLSPISNKQLIQMKLTEKNLSQCLHHHG---GLLPKSSRQYKFTHPELSNACGNIADGDLLAQYVTLPYSQRTEIAKKAG 1399
            EM+L  LP GY +     ++ + +  + +F+Q+HI+SKT+A++ +      S++ LNAE +KEEE + R    +   L  YTL+ YA  L      +W+P+P+A + FE W+ V+CMTT QL S+ T+ GTKD+LA+G+N++YGEEIPVRG+I+I+D+IDVVPEPGQ LTRHK+K IYD EQKGPVTA+TSC+G+L+SAIGQK+YIW LK+ +LVGVAFVDSE+Y+  L CV+NL+L  D LKSI LLRFQSDLRVLS+VS+D+  R V  SNFFVD   LGF ++D H N++IYSY+PL   SR+G++LVR AD++LP   TCSLR+ +R+R              P+  S++ V  ++                                E L+ S+Y G  SGA+F L P+ +K   ++++TEKNL   +HH G   G+LPKS   Y+   PEL+N CG +AD DLL +Y+ +P+SQR EIA+K+G
Sbjct: 1166 EMRLATLPPGYSFNEPLGMRWVPLQITPYFLQYHIESKTYAVVGTRPEPCSSVYHLNAEGNKEEEQLLRPPTCVLPSLDRYTLQIYAPSLLPSERFMWQPIPNASIEFEAWEVVTCMTTAQLASEQTFHGTKDYLALGTNLTYGEEIPVRGRIIILDLIDVVPEPGQPLTRHKLKTIYDGEQKGPVTAMTSCQGHLISAIGQKVYIWTLKNGDLVGVAFVDSELYIHSLLCVKNLVLAADVLKSIHLLRFQSDLRVLSVVSRDNIPREVYTSNFFVDGRRLGFAVSDEHGNVVIYSYDPLDSSSRSGRRLVRRADLRLPARATCSLRVANRLRHALLSVKPSSHTNQPVTSSATGVNTSESSEPIVSAVAPSGGQKTALTASMQTSAPPVDPERLKHSIYLGTQSGAVFLLGPLRDKMYSRLRITEKNL---IHHFGPTCGMLPKSCWNYRSPLPELANPCGQVADADLLWRYLVIPHSQRLEIARKSG 1651
[Close]
BLAST of Cleavage and polyadenylation specificity factor subunit 1 vs. TrEMBL
Match: A0A3R7GXT4 (Cleavage and polyadenylation specificity factor subunit 1 OS=Clonorchis sinensis OX=79923 GN=Cpsf1 PE=4 SV=1)

HSP 1 Score: 460.685 bits (1184), Expect = 3.472e-143
Identity = 242/520 (46.54%), Postives = 334/520 (64.23%), Query Frame = 2 
Query:   71 HIYY*GEMKLLNLPSGYDYEYQKAVKRISMNRSVHFVQFHIDSKTFAIITSEDREVMSIFKLNAENSKEEEPIERDSDIIRAPLPIYTLEFYANELS----GLWEPVPHAKVVFEDWDKVSCMTTVQLFSQMTYSGTKDFLAVGSNMSYGEEIPVRGKIMIVDIIDVVPEPGQVLTRHKMKIIYDVEQKGPVTALTSCKGYLVSAIGQKMYIWELKDNELVGVAFVDSEIYVQQLHCVRNLILTGDFLKSIQLLRFQSDLRVLSLVSKDSHARGVTCSNFFVDNENLGFMLADTHANIIIYSYNPLIEESRNGKQLVRNADIKLPITVTCSLRINDRIRDPILYSSSSVTMAQ--------------------------------------------------ELLRQSVYFGAASGAIFRLSPISNKQLIQMKLTEKNLSQCLHHHG---GLLPKSSRQYKFTHPELSNACGNIADGDLLAQYVTLPYSQRTEIAKKAGVEXXXXXXXXXXXYSSTLHF 1459
            +  Y  EM+L  L  GY ++    ++ + +  + +F+Q+HI+SKT+A++ +  +   S++ LNAE +KEEE + R    +   L  Y L+ YA   S      W+ +PHA + FE W+ V+CM T QL S+ T+ GTKD+LA+G+N+SYGEEIPVRG+I+I+D+IDVVPEPGQ LTRHK+K IYD EQKGPVTAL+SC+G+LVSAIGQK+YIW LK+ +LVGVAFVDSE+Y+  L CV+NLIL  D LKSIQLLRFQSDLRVLS+VS+D+  R V  SNFFVD   LGF++ D   N++IYSY+PL   SR+G++LVR AD+ LP     SLR+ +R+R  +L   S+ T  Q                                                  E L+ SVY G  +GA+F + P+ +K   ++++TEKNL   +HH G   GLLPK    Y+ + PEL N  G +AD DLL +Y+TLP+SQR EIAKK+G  ++ I+DD+ ++ ++TLHF
Sbjct: 1223 YFTYSNEMRLATLLPGYSFKEHLGMRWVPLELTPYFLQYHIESKTYALVGTRVKSCSSVYHLNAEGNKEEEVLLRPPTCVLPSLDYYVLQMYAPSTSLAEATPWQAIPHACIDFEPWEVVTCMITAQLSSEQTFHGTKDYLALGANLSYGEEIPVRGRIIILDVIDVVPEPGQPLTRHKLKTIYDGEQKGPVTALSSCQGHLVSAIGQKVYIWTLKNADLVGVAFVDSELYIHSLLCVKNLILAADVLKSIQLLRFQSDLRVLSVVSRDAIPREVYTSNFFVDGRRLGFLVTDERGNVVIYSYDPLEPSSRSGRRLVRRADMCLPTRAISSLRVANRLRHALLSVKSAGTGTQTTVPSAAGVGGSEVLERTGKTGVSSFVAPGRANSASAMTLSTPSATNIDPEKLKHSVYLGTQTGAVFLIGPLRDKMYSRLRITEKNL---IHHFGPTCGLLPKLCWNYRPSAPELVNPSGQVADADLLWRYLTLPHSQRLEIAKKSGQSLEGIMDDIAELNATTLHF 1739
[Close]
BLAST of Cleavage and polyadenylation specificity factor subunit 1 vs. TrEMBL
Match: H2KV89 (Cleavage and polyadenylation specificity factor subunit 1 OS=Clonorchis sinensis OX=79923 GN=CLF_111560 PE=4 SV=1)

HSP 1 Score: 460.685 bits (1184), Expect = 3.929e-143
Identity = 242/520 (46.54%), Postives = 334/520 (64.23%), Query Frame = 2 
Query:   71 HIYY*GEMKLLNLPSGYDYEYQKAVKRISMNRSVHFVQFHIDSKTFAIITSEDREVMSIFKLNAENSKEEEPIERDSDIIRAPLPIYTLEFYANELS----GLWEPVPHAKVVFEDWDKVSCMTTVQLFSQMTYSGTKDFLAVGSNMSYGEEIPVRGKIMIVDIIDVVPEPGQVLTRHKMKIIYDVEQKGPVTALTSCKGYLVSAIGQKMYIWELKDNELVGVAFVDSEIYVQQLHCVRNLILTGDFLKSIQLLRFQSDLRVLSLVSKDSHARGVTCSNFFVDNENLGFMLADTHANIIIYSYNPLIEESRNGKQLVRNADIKLPITVTCSLRINDRIRDPILYSSSSVTMAQ--------------------------------------------------ELLRQSVYFGAASGAIFRLSPISNKQLIQMKLTEKNLSQCLHHHG---GLLPKSSRQYKFTHPELSNACGNIADGDLLAQYVTLPYSQRTEIAKKAGVEXXXXXXXXXXXYSSTLHF 1459
            +  Y  EM+L  L  GY ++    ++ + +  + +F+Q+HI+SKT+A++ +  +   S++ LNAE +KEEE + R    +   L  Y L+ YA   S      W+ +PHA + FE W+ V+CM T QL S+ T+ GTKD+LA+G+N+SYGEEIPVRG+I+I+D+IDVVPEPGQ LTRHK+K IYD EQKGPVTAL+SC+G+LVSAIGQK+YIW LK+ +LVGVAFVDSE+Y+  L CV+NLIL  D LKSIQLLRFQSDLRVLS+VS+D+  R V  SNFFVD   LGF++ D   N++IYSY+PL   SR+G++LVR AD+ LP     SLR+ +R+R  +L   S+ T  Q                                                  E L+ SVY G  +GA+F + P+ +K   ++++TEKNL   +HH G   GLLPK    Y+ + PEL N  G +AD DLL +Y+TLP+SQR EIAKK+G  ++ I+DD+ ++ ++TLHF
Sbjct: 1225 YFTYSNEMRLATLLPGYSFKEHLGMRWVPLELTPYFLQYHIESKTYALVGTRVKSCSSVYHLNAEGNKEEEVLLRPPTCVLPSLDYYVLQMYAPSTSLAEATPWQAIPHACIDFEPWEVVTCMITAQLSSEQTFHGTKDYLALGANLSYGEEIPVRGRIIILDVIDVVPEPGQPLTRHKLKTIYDGEQKGPVTALSSCQGHLVSAIGQKVYIWTLKNADLVGVAFVDSELYIHSLLCVKNLILAADVLKSIQLLRFQSDLRVLSVVSRDAIPREVYTSNFFVDGRRLGFLVTDERGNVVIYSYDPLEPSSRSGRRLVRRADMCLPTRAISSLRVANRLRHALLSVKSAGTGTQTTVPSAAGVGGSEVLERTGKTGVSSFVAPGRANSASAMTLSTPSATNIDPEKLKHSVYLGTQTGAVFLIGPLRDKMYSRLRITEKNL---IHHFGPTCGLLPKLCWNYRPSAPELVNPSGQVADADLLWRYLTLPHSQRLEIAKKSGQSLEGIMDDIAELNATTLHF 1741
[Close]
BLAST of Cleavage and polyadenylation specificity factor subunit 1 vs. TrEMBL
Match: A0A5K3EZJ4 (Uncharacterized protein OS=Mesocestoides corti OX=53468 PE=4 SV=1)

HSP 1 Score: 457.218 bits (1175), Expect = 6.585e-143
Identity = 231/488 (47.34%), Postives = 330/488 (67.62%), Query Frame = 2 
Query:   89 EMKLLNLPSGYDYEYQKAVKRISMNRSVHFVQFHIDSKTFAIITSEDREVMSIFKLNAENSKEEEPIERDSDIIRAPLPIYTLEFYANELSGL------WEPVPHAKVVFEDWDKVSCMTTVQLFSQMTYSGTKDFLAVGSNMSYGEEIPVRGKIMIVDIIDVVPEPGQVLTRHKMKIIYDVEQKGPVTALTSCKGYLVSAIGQKMYIWELKDNELVGVAFVDSEIYVQQLHCVRNLILTGDFLKSIQLLRFQSDLRVLSLVSKDSHARGVTCSNFFVDNENLGFMLADTHANIIIYSYNPLIEESRNGKQLVRNADIKLPITVTCSLRINDRIRDPILY-------------------------SSSSVTMAQELLRQSVYFGAASGAIFRLSPISNKQLIQMKLTEKNLSQCLHHHGGLLPKSSRQYKFTHPELSNACGNIADGDLLAQYVTLPYSQRTEIAKKAGVEXXXXXXXXXXXYSSTLHF 1459
            EMKL  LP GY YE +  +  I ++    F+Q+H++SKT+ +++S +    +I +LNA+ +KEEE ++R    +   L IY ++  A   S        +E VP++ + FE +++V+C+ T QL S +T++ +KD+LA+GSN+SYGEEIPVRG+I++VDII+VVPEPG  LTRHK+K +YD +QKGPVTAL SC+GYL+SA+GQK+YIW LK  +L GVAFVD+++Y+  L CV+NLIL  D LKSIQLLRFQS +RVLSLVS+DS  R V  +NFFVD   LGF++ D   N+++YSY+P    S +G++LVR AD++LP   T SLR+++R R P+L                          SS   T+  E  R SVYFG  +GAI+ ++PI +K   ++++ EKNL QC     GL+P+  RQY    PELSN+CGN+ADGDL+ +Y+ LP+ QR E+AKK+G  ++ I+DD+ +I + TLHF
Sbjct: 1063 EMKLATLPPGYSYEGEVGISTIPLDACPRFLQYHLESKTYIVVSSTETPCHTIVRLNADGNKEEELVDRPETCVFPSLDIYKMQVIAPLPSSRPNDPPRFEVVPNSVIEFEPFEEVTCLVTAQLSSDLTFNESKDYLALGSNLSYGEEIPVRGRIVLVDIIEVVPEPGLPLTRHKVKTVYDGDQKGPVTALASCQGYLISAVGQKIYIWALKGGDLEGVAFVDTDLYIHSLVCVKNLILAADVLKSIQLLRFQSSMRVLSLVSRDSALREVFAANFFVDGIKLGFLITDNFGNLLVYSYDPEEPASCSGRRLVRRADMRLPSVATTSLRVSNRFRHPLLSTKALQAEVNELRRATGGKLMPPVAGSSLLATLEYERSRHSVYFGTRTGAIYLITPIRDKMFSRLRIVEKNLVQCSGCLAGLIPRVCRQYNQPFPELSNSCGNVADGDLILRYLLLPHGQRLEVAKKSGQSLESIMDDIAEICAITLHF 1550
[Close]
BLAST of Cleavage and polyadenylation specificity factor subunit 1 vs. TrEMBL
Match: A0A4V3SHB5 (CPSF_A domain-containing protein OS=Opisthorchis felineus OX=147828 GN=CRM22_000249 PE=4 SV=1)

HSP 1 Score: 460.685 bits (1184), Expect = 6.638e-143
Identity = 242/520 (46.54%), Postives = 333/520 (64.04%), Query Frame = 2 
Query:   71 HIYY*GEMKLLNLPSGYDYEYQKAVKRISMNRSVHFVQFHIDSKTFAIITSEDREVMSIFKLNAENSKEEEPIERDSDIIRAPLPIYTLEFYANELS----GLWEPVPHAKVVFEDWDKVSCMTTVQLFSQMTYSGTKDFLAVGSNMSYGEEIPVRGKIMIVDIIDVVPEPGQVLTRHKMKIIYDVEQKGPVTALTSCKGYLVSAIGQKMYIWELKDNELVGVAFVDSEIYVQQLHCVRNLILTGDFLKSIQLLRFQSDLRVLSLVSKDSHARGVTCSNFFVDNENLGFMLADTHANIIIYSYNPLIEESRNGKQLVRNADIKLPITVTCSLRINDRIRDPILYSSSSVTMAQ--------------------------------------------------ELLRQSVYFGAASGAIFRLSPISNKQLIQMKLTEKNLSQCLHHHG---GLLPKSSRQYKFTHPELSNACGNIADGDLLAQYVTLPYSQRTEIAKKAGVEXXXXXXXXXXXYSSTLHF 1459
            +  Y  EM+L  L  GY ++    ++ + +  + +F+Q+HI+SKT+A++ +  +   S++ LNAE +KEEE + R    +   L  Y L+ YA   S      W+ +PHA + FE W+ V+CM T QL S+ T+ GTKD+LA+G+N+SYGEEIPVRG+I+I+D+IDVVPEPGQ LTRHK+K IYD EQKGPVTAL+SC+G+LVSAIGQK+YIW LK+ +LVGVAFVDSE+Y+  L CV+NLIL  D LKSIQLLRFQSDLRVLS+VS+D+  R V  SNFFVD   LGF + D   N++IYSY+PL   SR+G++LVR AD+ LP     SLR+ +R+R  +L   S+ T  Q                                                  E L+ SVY G  +GA+F + P+ +K   ++++TEKNL   +HH G   GLLPK    Y+ + PEL N  G +AD DLL +Y+TLP+SQR EIAKK+G  ++ I+DD+ ++ ++TLHF
Sbjct: 1287 YFTYSNEMRLATLLPGYSFQEHLGMRWVPLELTPYFLQYHIESKTYALVGTRVKSCSSVYHLNAEGNKEEEVLLRPPTCVLPSLDYYVLQMYAPSTSLTEGTPWQAIPHACIDFEPWEVVTCMITAQLSSEQTFHGTKDYLALGANLSYGEEIPVRGRIIILDVIDVVPEPGQPLTRHKLKTIYDGEQKGPVTALSSCQGHLVSAIGQKVYIWTLKNADLVGVAFVDSELYIHSLLCVKNLILAADVLKSIQLLRFQSDLRVLSVVSRDAIPREVYTSNFFVDGRRLGFSVTDERGNVVIYSYDPLEPSSRSGRRLVRRADMCLPTRAISSLRVANRLRHALLSVKSASTGTQTTVTPAASVAGSEVLERTGKTGVSSLVAPGRVNSASGMTLTTPSATNLDPEKLKHSVYLGTQTGAVFLIGPLRDKMYSRLRITEKNL---IHHFGPTCGLLPKLCWNYRPSAPELVNPSGQVADADLLWRYLTLPHSQRLEIAKKSGQSLEGIMDDIAELNATTLHF 1803
[Close]
BLAST of Cleavage and polyadenylation specificity factor subunit 1 vs. Ensembl Cavefish
Match: cpsf1 (cleavage and polyadenylation specific factor 1 [Source:ZFIN;Acc:ZDB-GENE-040709-2])

HSP 1 Score: 243.047 bits (619), Expect = 9.862e-70
Identity = 144/439 (32.80%), Postives = 239/439 (54.44%), Query Frame = 2 
Query:   86 GEMKLLNLPSGYDYEYQKAVKRISMNRSVHFVQFHIDSKTFAIITSEDREVMSIFKLNAENSKEEEPIERDSDIIRAPLPIYTLEFYANELSGLWEPVPHAKVVFEDWDKVSCMTTVQLFSQMTYSGTKDFLAVGSNMSYGEEIPVRGKIMIVDIIDVVPEPGQVLTRHKMKIIYDVEQKGPVTALTSCKGYLVSAIGQKMYIWELKDNELVGVAFVDSEIYVQQLHCVRNLILTGDFLKSIQLLRFQSDLRVLSLVSKDSHARGVTCSNFFVDNENLGFMLADTHANIIIYSYNPLIEESRNGKQLVRNADIKLPITVTCSLRINDR-IRDPILYSSSSVTMAQELLRQSVYFGAASGAIFRLSPISNKQLIQMKLTEKNLSQCLHHHGGLLPKSSRQYKFTHPELSNACGNIADGDLLAQYVTLPYSQRTEIAKKAG 1399
            GE+++  LP+   Y+    V++I +  +VH+V +H++SK +A+ +S +     I ++  E  KE E IERD   I      ++++  +      WE +P+ ++  E+W+ V+CM TV L SQ T SG K ++A+G+ +  GEE+  RG++ +V    V+P     ++   + ++Y V               L+      +++W LKDN+L G+AF+D+++Y+ Q++ ++N IL  D +KSI LLR+Q + + LSLVS+D+    V    F VDN  LGF+++D   N+++Y Y P  +ES  G +L+R AD  +   V    R+  R + DP   S  S+T      +   +F    G I  L P+  K   ++ + +  L+  L HH GL PK+ R        L NA  NI DG+LL +Y+ L   +R+E+AKK G
Sbjct:  931 GELRISVLPTYLSYDAPWPVRKIPLRCTVHYVAYHVESKVYAVCSSINEPCTRIPRMTGEE-KEFETIERDERYIHPQQEKFSIQLIS---PVSWEAIPNTRIDLEEWEHVTCMKTVALKSQETVSGLKGYVALGTCLMQGEEVTCRGRVRLVS--PVLPH----VSNCSVPVLYCV---------------LI------IFLWSLKDNDLTGMAFIDTQLYIHQMYSIKNFILAADVMKSISLLRYQPESKTLSLVSRDAKPLEVYSIEFMVDNNQLGFLVSDRDKNLMVYMYLPEAKESFGGMRLLRRADFNVGANVNTFWRMPCRGLLDPA--SKKSLTWDN---KHITWFATLDGGIGLLLPMQEKTYRRLLMLQNALTTMLPHHAGLNPKAFRMLHTDRRTLQNAVRNILDGELLNKYLYLSGMERSELAKKIG 1333
[Close]
BLAST of Cleavage and polyadenylation specificity factor subunit 1 vs. Ensembl Yeast
Match: CFT1 (RNA-binding subunit of the mRNA cleavage and polyadenylation factor; involved in poly(A) site recognition and required for both pre-mRNA cleavage and polyadenylation, 51% sequence similarity with mammalian AAUAA-binding subunit of CPSF [Source:SGD;Acc:S000002709])

HSP 1 Score: 105.531 bits (262), Expect = 2.691e-24
Identity = 76/314 (24.20%), Postives = 156/314 (49.68%), Query Frame = 2 
Query:  470 KDFLAVGSNMSYGEEIPVRGKIMIVDIIDVVPEPGQVLTRHKMKIIYDVEQKGPVTALTSCKGYLVSAIGQKMYIWELK-DNELVGVAFVDSEIYVQQLHCVRNLILTGDFLKSIQLLRFQSD-LRVLSLVSKDSHARGVTCSNFFVDNENLGFMLADTHANIIIYSYNPLIEESRNGKQLVRNADIKLPITVTCSLRI--NDRIRDPILYSSSSVTMAQELLRQSVYFGAASGAIFRLSPISNKQLIQMKLTEKNLSQCLHHHGGLLPKSSRQYKFTHPELSNACGNIADGDLLAQYVTLPYSQRTEIAKKAG 1399
            ++++  G   +  E+ P  G   I D+I+VVPEPG+  T +K+K I+  E  G V+ +    G  + +  QK+ + +++ DN ++ VAF+D  ++V       NL++ GD ++  Q + F ++  R++SL    S  + ++   F V+  ++ F   D   N+ +  Y P    S +G++LV  +   L  T +C + +  N+    P + S  +V             G   G++F++ P+S ++  ++ + ++ +       GGL P+  R     + ++ ++   + D +++ ++  L   +R  IA+KAG
Sbjct: 1033 REYIIAGVANATTEDTPPTGAFHIYDVIEVVPEPGKPDTNYKLKEIFQEEVSGTVSTVCEVSGRFMISQSQKVLVRDIQEDNSVIPVAFLDIPVFVTDSKSFGNLLIIGDAMQGFQFIGFDAEPYRMISLGRSMSKFQTMSLE-FLVNGGDMYFAATDADRNVHVLKYAPDEPNSLSGQRLVHCSSFTLHSTNSCMMLLPRNEEFGSPQVPSFQNVG------------GQVDGSVFKIVPLSEEKYRRLYVIQQQIIDRELQLGGLNPRMERLANDFY-QMGHSMRPMLDFNVIRRFCGLAIDRRKSIAQKAG 1332
[Close]
BLAST of Cleavage and polyadenylation specificity factor subunit 1 vs. Ensembl Nematostella
Match: EDO34530 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7SP44])

HSP 1 Score: 313.153 bits (801), Expect = 1.233e-94
Identity = 161/438 (36.76%), Postives = 266/438 (60.73%), Query Frame = 2 
Query:   86 GEMKLLNLPSGYDYEYQKAVKRISMNRSVHFVQFHIDSKTFAIITSEDREVMSIFKLNAENSKEEEPIERDSDIIRAPLPIYTLEFYANELSGLWEPVPHAKVVFEDWDKVSCMTTVQLFSQMTYSGTKDFLAVGSNMSYGEEIPVRGKIMIVDIIDVVPEPGQVLTRHKMKIIYDVEQKGPVTALTSCKGYLVSAIGQKMYIWELKDNELVGVAFVDSEIYVQQLHCVRNLILTGDFLKSIQLLRFQSDLRVLSLVSKDSHARGVTCSNFFVDNENLGFMLADTHANIIIYSYNPLIEESRNGKQLVRNADIKLPITVTCSLRINDRIRDPILYSSSSVTMAQELLRQSVYFGAASGAIFRLSPISNKQLIQMKLTEKNLSQCLHHHGGLLPKSSRQYKFTHPELSNACGNIADGDLLAQYVTLPYSQRTEIAKKAG 1399
            GE+++  LP+   Y+    V+++ +  + H V ++ +SKT+AI+TSE      I ++ AE+ +  + I RD+  I      + L+  +  +S  WE +P+ +   ++W+ V+ M  + L S+ T++G K F+ VG+   YGEEI VRG+I+I DII+VVPEPGQ LT++K K++Y+ EQKGPVTAL    GYLVS IGQK+YIW   DN+LVG+AF+D+++Y+  L  +RN ++  D  KSI LLR Q + + L+ VSKD     V  ++FF+D   +GF+++D   N+++++Y P   ES+ G++L++ ADI +   +T   RI  +      +  +S   ++E +RQ   FG   GA+  + P++ K   ++ + +  L  C+ H  GL PK+ R  ++   +L N   N+ D  LL +Y+ L + +R E+A+K G
Sbjct:  973 GELRISVLPTHLSYDSPWPVRKVPLRYTPHMVSYNRESKTYAIVTSEQEPCKKIPRVTAEDKEFVDTI-RDARFIYPSTERFVLQLIS-PIS--WEVIPNTRHDLDEWEHVTTMKNLLLHSEETHTGRKGFICVGTTQLYGEEIAVRGRILIFDIIEVVPEPGQPLTKNKFKLLYEKEQKGPVTALNQVNGYLVSGIGQKIYIWNFTDNDLVGMAFIDTQLYIHSLVTIRNFVIAADVCKSITLLRLQEETKTLAFVSKDPKNLEVYAADFFIDGPQIGFLVSDVEKNLVLFTYQPEAIESQGGQRLLQRADINVGTHITSFFRIAAKA-----HLKASGEKSKE-MRQLTCFGTLDGALGLMLPMTEKTFRRLHMLQTKLVDCIPHVAGLNPKAFRMLQWRKRKLCNPHRNVLDWQLLFKYMHLSFMERQEVARKIG 1400
[Close]
BLAST of Cleavage and polyadenylation specificity factor subunit 1 vs. Ensembl Medaka
Match: cpsf1 (cleavage and polyadenylation specific factor 1 [Source:NCBI gene;Acc:101172177])

HSP 1 Score: 330.102 bits (845), Expect = 4.270e-100
Identity = 176/442 (39.82%), Postives = 263/442 (59.50%), Query Frame = 2 
Query:   86 GEMKLLNLPSGYDYEYQKAVKRISMNRSVHFVQFHIDSKTFAIITSEDREVMSIFKLNAENSKEEEPIERDSDIIRAPLPIYTLEFYANELSGLWEPVPHAKVVFEDWDKVSCMTTVQLFSQMTYSGTKDFLAVGSNMSYGEEIPVRGKIMIVDIIDVVPEPGQVLTRHKMKIIYDVEQKGPVTALTSCKGYLVSAIGQKMYIWELKDNELVGVAFVDSEIYVQQLHCVRNLILTGDFLKSIQLLRFQSDLRVLSLVSKDSHARGVTCSNFFVDNENLGFMLADTHANIIIYSYNPLIEESRNGKQLVRNADIKLPITVTCSLRINDRIRDPI---LYSSSSVTMAQELLRQSVYFGAASGAIFRLSPISNKQLIQMKLTEKNLSQCLHHHGGLLPKSSRQYKFTHPELSNACGNIADGDLLAQYVTLPYSQRTEIAKKAGV 1402
            GE+++  LP+   Y+    V++I +  +VHFV +H++SK +A+ TS       I ++  E  KE E IERD   I      ++++  +      WE +P+ ++  E+W+ V+CM TV L SQ T SG K ++A G+ +  GEE+  RG+I+I+D+I+VVPEPGQ LT++K K++Y+ EQKGPVTAL  C GYLVSAIGQK+++W LKDN+L G+AF+D+++Y+ Q+  ++N IL  D +KSI LLR+Q + + LSLVS+D+    V    F VDN  LGF+++D   N+ +Y Y P  +ES  G +L+R AD            IN   R P    L S S   +  +  +   +F    G I  L P+  K   ++ + +  L+  L HH GL PK+ R        L NA  NI DG+LLA+Y+ L   +R+E+AKK G 
Sbjct: 1014 GELRISVLPTYLSYDAPWPVRKIPLRCTVHFVSYHVESKVYAVCTSVKELCTRIPRMTGEE-KEFETIERDERYINPLQEKFSIQLIS---PVSWETIPNTRIDLEEWEHVTCMKTVALRSQETVSGLKGYIAAGTCVLQGEEVTCRGRILILDVIEVVPEPGQPLTKNKFKVLYEKEQKGPVTALCHCHGYLVSAIGQKIFLWALKDNDLTGMAFIDTQLYIHQMISIKNFILAADVMKSISLLRYQEESKTLSLVSRDAKPLEVYSIEFIVDNNQLGFLVSDRDKNLFVYMYLPEAKESFGGMRLLRRADF------NAGAHINSLWRMPCRGALDSGSKKALTWD-NKHITWFATLDGGIGLLLPMQEKTYRRLLMLQNALTTMLPHHAGLNPKAFRMMHSNRRSLQNAVKNILDGELLAKYLYLSTMERSELAKKIGT 1444
[Close]
BLAST of Cleavage and polyadenylation specificity factor subunit 1 vs. Ensembl Medaka
Match: cpsf1 (cleavage and polyadenylation specific factor 1 [Source:NCBI gene;Acc:101172177])

HSP 1 Score: 330.102 bits (845), Expect = 4.830e-100
Identity = 176/442 (39.82%), Postives = 263/442 (59.50%), Query Frame = 2 
Query:   86 GEMKLLNLPSGYDYEYQKAVKRISMNRSVHFVQFHIDSKTFAIITSEDREVMSIFKLNAENSKEEEPIERDSDIIRAPLPIYTLEFYANELSGLWEPVPHAKVVFEDWDKVSCMTTVQLFSQMTYSGTKDFLAVGSNMSYGEEIPVRGKIMIVDIIDVVPEPGQVLTRHKMKIIYDVEQKGPVTALTSCKGYLVSAIGQKMYIWELKDNELVGVAFVDSEIYVQQLHCVRNLILTGDFLKSIQLLRFQSDLRVLSLVSKDSHARGVTCSNFFVDNENLGFMLADTHANIIIYSYNPLIEESRNGKQLVRNADIKLPITVTCSLRINDRIRDPI---LYSSSSVTMAQELLRQSVYFGAASGAIFRLSPISNKQLIQMKLTEKNLSQCLHHHGGLLPKSSRQYKFTHPELSNACGNIADGDLLAQYVTLPYSQRTEIAKKAGV 1402
            GE+++  LP+   Y+    V++I +  +VHFV +H++SK +A+ TS       I ++  E  KE E IERD   I      ++++  +      WE +P+ ++  E+W+ V+CM TV L SQ T SG K ++A G+ +  GEE+  RG+I+I+D+I+VVPEPGQ LT++K K++Y+ EQKGPVTAL  C GYLVSAIGQK+++W LKDN+L G+AF+D+++Y+ Q+  ++N IL  D +KSI LLR+Q + + LSLVS+D+    V    F VDN  LGF+++D   N+ +Y Y P  +ES  G +L+R AD            IN   R P    L S S   +  +  +   +F    G I  L P+  K   ++ + +  L+  L HH GL PK+ R        L NA  NI DG+LLA+Y+ L   +R+E+AKK G 
Sbjct: 1014 GELRISVLPTYLSYDAPWPVRKIPLRCTVHFVSYHVESKVYAVCTSVKELCTRIPRMTGEE-KEFETIERDERYINPLQEKFSIQLIS---PVSWETIPNTRIDLEEWEHVTCMKTVALRSQETVSGLKGYIAAGTCVLQGEEVTCRGRILILDVIEVVPEPGQPLTKNKFKVLYEKEQKGPVTALCHCHGYLVSAIGQKIFLWALKDNDLTGMAFIDTQLYIHQMISIKNFILAADVMKSISLLRYQEESKTLSLVSRDAKPLEVYSIEFIVDNNQLGFLVSDRDKNLFVYMYLPEAKESFGGMRLLRRADF------NAGAHINSLWRMPCRGALDSGSKKALTWD-NKHITWFATLDGGIGLLLPMQEKTYRRLLMLQNALTTMLPHHAGLNPKAFRMMHSNRRSLQNAVKNILDGELLAKYLYLSTMERSELAKKIGT 1444
[Close]
BLAST of Cleavage and polyadenylation specificity factor subunit 1 vs. Ensembl Medaka
Match: cpsf1 (cleavage and polyadenylation specific factor 1 [Source:NCBI gene;Acc:101172177])

HSP 1 Score: 237.269 bits (604), Expect = 1.262e-74
Identity = 112/241 (46.47%), Postives = 163/241 (67.63%), Query Frame = 2 
Query:  272 KEEEPIERDSDIIRAPLPIYTLEFYANELSGLWEPVPHAKVVFEDWDKVSCMTTVQLFSQMTYSGTKDFLAVGSNMSYGEEIPVRGKIMIVDIIDVVPEPGQVLTRHKMKIIYDVEQKGPVTALTSCKGYLVSAIGQKMYIWELKDNELVGVAFVDSEIYVQQLHCVRNLILTGDFLKSIQLLRFQSDLRVLSLVSKDSHARGVTCSNFFVDNENLGFMLADTHANIIIYSYNPLIEESRN 994
            KE E IERD   I      ++++  +      WE +P+ ++  E+W+ V+CM TV L SQ T SG K ++A G+ +  GEE+  RG+I+I+D+I+VVPEPGQ LT++K K++Y+ EQKGPVTAL  C GYLVSAIGQK+++W LKDN+L G+AF+D+++Y+ Q+  ++N IL  D +KSI LLR+Q + + LSLVS+D+    V    F VDN  LGF+++D   N+ +Y Y P   E R 
Sbjct:    6 KEFETIERDERYINPLQEKFSIQLIS---PVSWETIPNTRIDLEEWEHVTCMKTVALRSQETVSGLKGYIAAGTCVLQGEEVTCRGRILILDVIEVVPEPGQPLTKNKFKVLYEKEQKGPVTALCHCHGYLVSAIGQKIFLWALKDNDLTGMAFIDTQLYIHQMISIKNFILAADVMKSISLLRYQEESKTLSLVSRDAKPLEVYSIEFIVDNNQLGFLVSDRDKNLFVYMYLPEGREFRG 243
[Close]
BLAST of Cleavage and polyadenylation specificity factor subunit 1 vs. Planmine SMEST
Match: SMESG000051959.1 (SMESG000051959.1)

HSP 1 Score: 923.694 bits (2386), Expect = 0.000e+0
Identity = 465/486 (95.68%), Postives = 465/486 (95.68%), Query Frame = 2 
Query:    2 FAYFNNRVRLYHP***DKSPD*HHIYY*GEMKLLNLPSGYDYEYQKAVKRISMNRSVHFVQFHIDSKTFAIITSEDREVMSIFKLNAENSKEEEPIERDSDIIRAPLPIYTLEFYANELSGLWEPVPHAKVVFEDWDKVSCMTTVQLFSQMTYSGTKDFLAVGSNMSYGEEIPVRGKIMIVDIIDVVPEPGQVLTRHKMKIIYDVEQKGPVTALTSCKGYLVSAIGQKMYIWELKDNELVGVAFVDSEIYVQQLHCVRNLILTGDFLKSIQLLRFQSDLRVLSLVSKDSHARGVTCSNFFVDNENLGFMLADTHANIIIYSYNPLIEESRNGKQLVRNADIKLPITVTCSLRINDRIRDPILYSSSSVTMAQELLRQSVYFGAASGAIFRLSPISNKQLIQMKLTEKNLSQCLHHHGGLLPKSSRQYKFTHPELSNACGNIADGDLLAQYVTLPYSQRTEIAKKAGVEXXXXXXXXXXXYSSTLHF 1459
            FAYFNNR                     GEMKLLNLPSGYDYEYQKAVKRISMNRSVHFVQFHIDSKTFAIITSEDREVMSIFKLNAENSKEEEPIERDSDIIRAPLPIYTLEFYANELSGLWEPVPHAKVVFEDWDKVSCMTTVQLFSQMTYSGTKDFLAVGSNMSYGEEIPVRGKIMIVDIIDVVPEPGQVLTRHKMKIIYDVEQKGPVTALTSCKGYLVSAIGQKMYIWELKDNELVGVAFVDSEIYVQQLHCVRNLILTGDFLKSIQLLRFQSDLRVLSLVSKDSHARGVTCSNFFVDNENLGFMLADTHANIIIYSYNPLIEESRNGKQLVRNADIKLPITVTCSLRINDRIRDPILYSSSSVTMAQELLRQSVYFGAASGAIFRLSPISNKQLIQMKLTEKNLSQCLHHHGGLLPKSSRQYKFTHPELSNACGNIADGDLLAQYVTLPYSQRTEIAKKAGVEIDKILDDLIDIYSSTLHF
Sbjct: 1082 FAYFNNR---------------------GEMKLLNLPSGYDYEYQKAVKRISMNRSVHFVQFHIDSKTFAIITSEDREVMSIFKLNAENSKEEEPIERDSDIIRAPLPIYTLEFYANELSGLWEPVPHAKVVFEDWDKVSCMTTVQLFSQMTYSGTKDFLAVGSNMSYGEEIPVRGKIMIVDIIDVVPEPGQVLTRHKMKIIYDVEQKGPVTALTSCKGYLVSAIGQKMYIWELKDNELVGVAFVDSEIYVQQLHCVRNLILTGDFLKSIQLLRFQSDLRVLSLVSKDSHARGVTCSNFFVDNENLGFMLADTHANIIIYSYNPLIEESRNGKQLVRNADIKLPITVTCSLRINDRIRDPILYSSSSVTMAQELLRQSVYFGAASGAIFRLSPISNKQLIQMKLTEKNLSQCLHHHGGLLPKSSRQYKFTHPELSNACGNIADGDLLAQYVTLPYSQRTEIAKKAGVEIDKILDDLIDIYSSTLHF 1546
The following BLAST results are available for this feature:
BLAST of Cleavage and polyadenylation specificity factor subunit 1 vs. Ensembl Human
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Human e!99)
Total hits: 5
Match NameE-valueIdentityDescription
CPSF12.456e-9738.04cleavage and polyadenylation specific factor 1 [So... [more]
CPSF12.456e-9738.04cleavage and polyadenylation specific factor 1 [So... [more]
CPSF12.456e-9738.04cleavage and polyadenylation specific factor 1 [So... [more]
CPSF12.456e-9738.04cleavage and polyadenylation specific factor 1 [So... [more]
CPSF11.466e-3542.51cleavage and polyadenylation specific factor 1 [So... [more]
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BLAST of Cleavage and polyadenylation specificity factor subunit 1 vs. Ensembl Celegans
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99)
Total hits: 3
Match NameE-valueIdentityDescription
cpsf-11.940e-7431.29Probable cleavage and polyadenylation specificity ... [more]
cpsf-12.917e-7431.52Probable cleavage and polyadenylation specificity ... [more]
cpsf-13.772e-6032.63Probable cleavage and polyadenylation specificity ... [more]
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BLAST of Cleavage and polyadenylation specificity factor subunit 1 vs. Ensembl Fly
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99)
Total hits: 2
Match NameE-valueIdentityDescription
Cpsf1603.222e-7735.97gene:FBgn0024698 transcript:FBtr0089257[more]
Cpsf1603.698e-7735.97gene:FBgn0024698 transcript:FBtr0089258[more]
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BLAST of Cleavage and polyadenylation specificity factor subunit 1 vs. Ensembl Zebrafish
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99)
Total hits: 2
Match NameE-valueIdentityDescription
cpsf11.012e-9938.81cleavage and polyadenylation specific factor 1 [So... [more]
cpsf11.271e-9938.81cleavage and polyadenylation specific factor 1 [So... [more]
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BLAST of Cleavage and polyadenylation specificity factor subunit 1 vs. Ensembl Xenopus
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99)
Total hits: 2
Match NameE-valueIdentityDescription
hnmt1.131e-2531.88histamine N-methyltransferase [Source:Xenbase;Acc:... [more]
hnmt1.854e-1628.50histamine N-methyltransferase [Source:Xenbase;Acc:... [more]
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BLAST of Cleavage and polyadenylation specificity factor subunit 1 vs. Ensembl Mouse
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99)
Total hits: 3
Match NameE-valueIdentityDescription
Cpsf14.809e-9737.41cleavage and polyadenylation specific factor 1 [So... [more]
Cpsf15.928e-9737.41cleavage and polyadenylation specific factor 1 [So... [more]
Cpsf15.141e-934.94cleavage and polyadenylation specific factor 1 [So... [more]
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BLAST of Cleavage and polyadenylation specificity factor subunit 1 vs. UniProt/SwissProt
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt)
Total hits: 5
Match NameE-valueIdentityDescription
sp|Q10570|CPSF1_HUMAN1.179e-9638.04Cleavage and polyadenylation specificity factor su... [more]
sp|Q9EPU4|CPSF1_MOUSE3.364e-9637.41Cleavage and polyadenylation specificity factor su... [more]
sp|Q10569|CPSF1_BOVIN6.454e-9536.96Cleavage and polyadenylation specificity factor su... [more]
sp|A8XPU7|CPSF1_CAEBR3.147e-7933.11Probable cleavage and polyadenylation specificity ... [more]
sp|Q9V726|CPSF1_DROME3.707e-7635.97Cleavage and polyadenylation specificity factor su... [more]
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BLAST of Cleavage and polyadenylation specificity factor subunit 1 vs. TrEMBL
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL)
Total hits: 5
Match NameE-valueIdentityDescription
A0A5J4NP062.221e-15047.85Cleavage and polyadenylation specificity factor su... [more]
A0A3R7GXT43.472e-14346.54Cleavage and polyadenylation specificity factor su... [more]
H2KV893.929e-14346.54Cleavage and polyadenylation specificity factor su... [more]
A0A5K3EZJ46.585e-14347.34Uncharacterized protein OS=Mesocestoides corti OX=... [more]
A0A4V3SHB56.638e-14346.54CPSF_A domain-containing protein OS=Opisthorchis f... [more]
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BLAST of Cleavage and polyadenylation specificity factor subunit 1 vs. Ensembl Cavefish
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99)
Total hits: 1
Match NameE-valueIdentityDescription
cpsf19.862e-7032.80cleavage and polyadenylation specific factor 1 [So... [more]
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BLAST of Cleavage and polyadenylation specificity factor subunit 1 vs. Ensembl Sea Lamprey
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99)
Total hits: 0
Match NameE-valueIdentityDescription
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BLAST of Cleavage and polyadenylation specificity factor subunit 1 vs. Ensembl Yeast
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46)
Total hits: 1
Match NameE-valueIdentityDescription
CFT12.691e-2424.20RNA-binding subunit of the mRNA cleavage and polya... [more]
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BLAST of Cleavage and polyadenylation specificity factor subunit 1 vs. Ensembl Nematostella
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46)
Total hits: 1
Match NameE-valueIdentityDescription
EDO345301.233e-9436.76Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7... [more]
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BLAST of Cleavage and polyadenylation specificity factor subunit 1 vs. Ensembl Medaka
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99)
Total hits: 3
Match NameE-valueIdentityDescription
cpsf14.270e-10039.82cleavage and polyadenylation specific factor 1 [So... [more]
cpsf14.830e-10039.82cleavage and polyadenylation specific factor 1 [So... [more]
cpsf11.262e-7446.47cleavage and polyadenylation specific factor 1 [So... [more]
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BLAST of Cleavage and polyadenylation specificity factor subunit 1 vs. Planmine SMEST
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST)
Total hits: 1
Match NameE-valueIdentityDescription
SMESG000051959.10.000e+095.68SMESG000051959.1[more]
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Sequences
The following sequences are available for this feature:

transcript sequence

>SMED30012540 ID=SMED30012540|Name=Cleavage and polyadenylation specificity factor subunit 1|organism=Schmidtea mediterranea sexual|type=transcript|length=1516bp
TTTCGCCTATTTCAACAATCGAGTTAGACTTTACCATCCCTAATAATAAG
ACAAATCCCCCGATTAACATCACATTTATTACTAGGGAGAAATGAAACTT
CTAAACTTGCCCAGCGGTTACGATTACGAGTACCAGAAAGCCGTCAAACG
AATCTCCATGAATCGCAGCGTTCATTTCGTTCAATTTCATATCGATAGTA
AAACATTTGCCATAATAACCAGCGAGGACAGAGAGGTAATGTCGATATTC
AAATTGAACGCGGAAAACAGTAAAGAAGAAGAACCAATAGAAAGAGATAG
CGATATAATTCGTGCACCGCTACCGATTTACACGTTGGAATTCTACGCCA
ATGAATTGAGTGGATTATGGGAGCCGGTTCCTCACGCAAAGGTTGTCTTT
GAGGACTGGGATAAGGTTTCCTGCATGACAACGGTTCAGTTGTTCTCCCA
AATGACATATTCCGGCACGAAGGATTTCCTCGCGGTCGGTAGCAACATGT
CTTATGGAGAGGAGATTCCAGTAAGAGGGAAAATAATGATTGTCGATATT
ATCGATGTCGTTCCGGAACCGGGGCAAGTTCTCACGAGACATAAAATGAA
AATCATTTATGACGTTGAACAGAAAGGCCCGGTTACCGCTTTAACGAGTT
GCAAAGGATATTTGGTGTCTGCCATCGGTCAAAAGATGTACATTTGGGAG
TTGAAAGACAACGAATTGGTCGGAGTGGCATTTGTTGATTCGGAAATCTA
CGTTCAGCAGCTCCATTGCGTTAGGAATCTGATTTTGACTGGGGATTTTC
TCAAATCAATTCAACTGTTGAGATTCCAGTCGGATTTGCGGGTTTTGTCG
CTGGTATCGAAGGACAGTCATGCTCGCGGTGTAACGTGCTCGAATTTCTT
TGTGGATAACGAGAATCTCGGGTTCATGTTGGCTGATACGCACGCCAATA
TCATCATATACAGCTACAATCCGTTGATTGAGGAGAGTAGAAATGGAAAA
CAGTTAGTCAGGAATGCCGATATTAAACTGCCGATTACTGTAACCTGTTC
GCTGCGCATTAATGACAGGATCAGGGATCCGATATTGTACAGTTCTAGTT
CAGTGACAATGGCACAGGAATTATTGAGGCAATCTGTTTATTTCGGCGCG
GCTTCCGGTGCAATATTTCGCCTGAGTCCCATTTCCAACAAACAGTTGAT
CCAGATGAAATTAACAGAAAAGAATTTGAGTCAATGTTTGCATCATCATG
GTGGACTGCTTCCAAAGTCGTCTCGCCAATACAAATTCACTCATCCGGAA
CTGAGTAACGCTTGCGGAAATATTGCAGATGGCGACCTGCTTGCTCAGTA
CGTTACATTGCCATACAGCCAGCGCACCGAGATCGCAAAGAAAGCCGGCG
TGGAAATTGATAAAATTCTGGATGATTTGATCGATATCTATTCGAGCACT
CTGCATTTCTAGTTTATTTATTTGTCAATATGTTAATAAATTTTCGGTTT
TTTCAATATTTTGCAC
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protein sequence of SMED30012540-orf-1

>SMED30012540-orf-1 ID=SMED30012540-orf-1|Name=SMED30012540-orf-1|organism=Schmidtea mediterranea sexual|type=polypeptide|length=457bp
MKLLNLPSGYDYEYQKAVKRISMNRSVHFVQFHIDSKTFAIITSEDREVM
SIFKLNAENSKEEEPIERDSDIIRAPLPIYTLEFYANELSGLWEPVPHAK
VVFEDWDKVSCMTTVQLFSQMTYSGTKDFLAVGSNMSYGEEIPVRGKIMI
VDIIDVVPEPGQVLTRHKMKIIYDVEQKGPVTALTSCKGYLVSAIGQKMY
IWELKDNELVGVAFVDSEIYVQQLHCVRNLILTGDFLKSIQLLRFQSDLR
VLSLVSKDSHARGVTCSNFFVDNENLGFMLADTHANIIIYSYNPLIEESR
NGKQLVRNADIKLPITVTCSLRINDRIRDPILYSSSSVTMAQELLRQSVY
FGAASGAIFRLSPISNKQLIQMKLTEKNLSQCLHHHGGLLPKSSRQYKFT
HPELSNACGNIADGDLLAQYVTLPYSQRTEIAKKAGVEIDKILDDLIDIY
SSTLHF*
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Annotated Terms
The following terms have been associated with this transcript:
Vocabulary: Planarian Anatomy
TermDefinition
PLANA:0002056medial muscle cell
PLANA:0002109X1 cell
PLANA:0002111X2 cell
Vocabulary: INTERPRO
TermDefinition
IPR036322WD40_repeat_dom_sf
IPR015943WD40/YVTN_repeat-like_dom_sf
IPR004871Cleavage/polyA-sp_fac_asu_C
IPR017986WD40_repeat_dom
Vocabulary: molecular function
TermDefinition
GO:0005515protein binding
GO:0003676nucleic acid binding
Vocabulary: cellular component
TermDefinition
GO:0005634nucleus
InterPro
Analysis Name: Schmidtea mediteranean smed_20140614 Interproscan
Date Performed: 2020-05-01
IPR TermIPR DescriptionSourceSource TermSource DescriptionAlignment
IPR004871Cleavage/polyadenylation specificity factor, A subunit, C-terminalPFAMPF03178CPSF_Acoord: 99..421
e-value: 1.2E-62
score: 212.1
IPR015943WD40/YVTN repeat-like-containing domain superfamilyGENE3DG3DSA:2.130.10.10coord: 11..362
e-value: 2.6E-56
score: 193.3
NoneNo IPR availablePANTHERPTHR10644:SF2CLEAVAGE AND POLYADENYLATION SPECIFICITY FACTOR SUBUNIT 1coord: 6..433
NoneNo IPR availablePANTHERPTHR10644DNA REPAIR/RNA PROCESSING CPSF FAMILYcoord: 6..433
IPR036322WD40-repeat-containing domain superfamilySUPERFAMILYSSF50978WD40 repeat-likecoord: 11..283