DIRP domain-containing protein

Overview
NameDIRP domain-containing protein
Smed IDSMED30012517
Length (bp)3708
Neoblast Clusters

Zeng et. al., 2018




▻ Overview

▻ Neoblast Population

▻ Sub-lethal Irradiated Surviving X1 and X2 Cell Population

 



 

Overview

 

Single cell RNA-seq of pluripotent neoblasts and its early progenies


We isolated X1 neoblasts cells enriched in high piwi-1 expression (Neoblast Population), and profiled ∼7,614 individual cells via scRNA-seq. Unsupervised analyses uncovered 12 distinct classes from 7,088 high-quality cells. We designated these classes Nb1 to Nb12 and ordered them based on high (Nb1) to low (Nb12) piwi-1 expression levels. We further defined groups of genes that best classified the cells parsed into 12 distinct cell clusters to generate a scaled expression heat map of discriminative gene sets for each cluster. Expression of each cluster’s gene signatures was validated using multiplex fluorescence in situ hybridization (FISH) co-stained with piwi-1 and largely confirmed the cell clusters revealed by scRNA-seq.

We also tested sub-lethal irradiation exposure. To profile rare pluripotent stem cells (PSCs) and avoid interference from immediate progenitor cells, we determined a time point after sub-lethal irradiation (7 DPI) with minimal piwi-1+ cells, followed by isolation and single-cell RNA-seq of 1,200 individual cells derived from X1 (Piwi-1 high) and X2 (Piwi-1 low) cell populations (Sub-lethal Irradiated Surviving X1 and X2 Cell Population)




Explore this single cell expression dataset with our NB Cluster Shiny App




 

Neoblast Population

 

t-SNE plot shows two-dimensional representation of global gene expression relationships among all neoblasts (n = 7,088 after filter). Cluster identity was assigned based on the top 10 marker genes of each cluster (Table S2), followed by inspection of RNA in situ hybridization patterns. Neoblast groups, Nb.


Expression of DIRP domain-containing protein (SMED30012517) t-SNE clustered cells

Violin plots show distribution of expression levels for DIRP domain-containing protein (SMED30012517) in cells (dots) of each of the 12 neoblast clusters.

 

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Sub-lethal Irradiated Surviving X1 and X2 Cell Population

 

t-SNE plot of surviving X1 and X2 cells (n = 1,039 after QC filter) after sub-lethal irradiation. Colors indicate unbiased cell classification via graph-based clustering. SL, sub-lethal irradiated cell groups.

Expression of DIRP domain-containing protein (SMED30012517) in the t-SNE clustered sub-lethally irradiated X1 and X2 cells.

Violin plots show distribution of expression levels for DIRP domain-containing protein (SMED30012517) in cells (dots) of each of the 10 clusters of sub-leathally irradiated X1 and X2 cells.

 

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Embryonic Expression

Davies et. al., 2017




Hover the mouse over a column in the graph to view average RPKM values per sample.
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Embryonic Stages: Y: yolk. S2-S8: Stages 2-8. C4: asexual adult. SX: virgin, sexually mature adult.
For further information about sample preparation and analysis for the single animal RNA-Seq experiment, please refer to the Materials and Methods

 

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Anatomical Expression

PAGE et. al., 2020




SMED30012517

has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGE



PAGE Curations: 3

  
Expressed InReference TranscriptGene ModelsPublished TranscriptTranscriptomePublicationSpecimenLifecycleEvidence
X1 cellSMED30012517SMESG000035510.1 SmedASXL_000024SmedAsxl_ww_GCZZ01PMID:26114597
Zhu et al., 2015
FACS sorted cell population asexual adult RNA-sequencing evidence
nervous systemSMED30012517SMESG000035512.1 SMESG000035510.1 dd_Smed_v4_8904_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018
FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
neoblastSMED30012517SMESG000035512.1 SMESG000035510.1 dd_Smed_v4_8904_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018
FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
Note: Hover over icons to view figure legend
Homology
BLAST of DIRP domain-containing protein vs. Ensembl Human
Match: LIN9 (lin-9 DREAM MuvB core complex component [Source:HGNC Symbol;Acc:HGNC:30830])

HSP 1 Score: 75.8702 bits (185), Expect = 2.122e-13
Identity = 44/130 (33.85%), Postives = 67/130 (51.54%), Query Frame = 3
Query:  141 KKPLFYYFNKY*STFIDLTFQLKMSNSFENYN-----RLSNFLKSKKVFNWISNELFYSEIDKSIFLGNNKLQLYISSYLPNLKTKKLNISQWRIIKKCFGKPIRMSKQYFIKKRKMLSEYRKNVRFVYQ 515
            K P++   N   S+ +++ F   MS   +  +     RL N LK  K   W   E FYS IDK +F G+N   + +    PNLKT+KL   +W  I++  GKP R S  +F ++R  L + R+ +R + Q
Sbjct:   49 KTPVWKGRNT--SSAVEMKFTATMSTPDKKASQKIGFRLRNLLKLPKAHKWCIYEWFYSNIDKPLFEGDNDFCVCLKESFPNLKTRKLTRVEWGKIRRLMGKPRRCSSAFFEEERSALKQKRQKIRLLQQ 176          
BLAST of DIRP domain-containing protein vs. Ensembl Human
Match: LIN9 (lin-9 DREAM MuvB core complex component [Source:HGNC Symbol;Acc:HGNC:30830])

HSP 1 Score: 75.8702 bits (185), Expect = 2.294e-13
Identity = 41/118 (34.75%), Postives = 62/118 (52.54%), Query Frame = 3
Query:  177 STFIDLTFQLKMSNSFENYN-----RLSNFLKSKKVFNWISNELFYSEIDKSIFLGNNKLQLYISSYLPNLKTKKLNISQWRIIKKCFGKPIRMSKQYFIKKRKMLSEYRKNVRFVYQ 515
            S+ +++ F   MS   +  +     RL N LK  K   W   E FYS IDK +F G+N   + +    PNLKT+KL   +W  I++  GKP R S  +F ++R  L + R+ +R + Q
Sbjct:   64 SSAVEMKFTATMSTPDKKASQKIGFRLRNLLKLPKAHKWCIYEWFYSNIDKPLFEGDNDFCVCLKESFPNLKTRKLTRVEWGKIRRLMGKPRRCSSAFFEEERSALKQKRQKIRLLQQ 181          
BLAST of DIRP domain-containing protein vs. Ensembl Human
Match: LIN9 (lin-9 DREAM MuvB core complex component [Source:HGNC Symbol;Acc:HGNC:30830])

HSP 1 Score: 74.7146 bits (182), Expect = 7.016e-13
Identity = 37/93 (39.78%), Postives = 52/93 (55.91%), Query Frame = 3
Query:  237 RLSNFLKSKKVFNWISNELFYSEIDKSIFLGNNKLQLYISSYLPNLKTKKLNISQWRIIKKCFGKPIRMSKQYFIKKRKMLSEYRKNVRFVYQ 515
            RL N LK  K   W   E FYS IDK +F G+N   + +    PNLKT+KL   +W  I++  GKP R S  +F ++R  L + R+ +R + Q
Sbjct:  124 RLRNLLKLPKAHKWCIYEWFYSNIDKPLFEGDNDFCVCLKESFPNLKTRKLTRVEWGKIRRLMGKPRRCSSAFFEEERSALKQKRQKIRLLQQ 216          
BLAST of DIRP domain-containing protein vs. Ensembl Human
Match: LIN9 (lin-9 DREAM MuvB core complex component [Source:HGNC Symbol;Acc:HGNC:30830])

HSP 1 Score: 74.7146 bits (182), Expect = 7.224e-13
Identity = 37/93 (39.78%), Postives = 52/93 (55.91%), Query Frame = 3
Query:  237 RLSNFLKSKKVFNWISNELFYSEIDKSIFLGNNKLQLYISSYLPNLKTKKLNISQWRIIKKCFGKPIRMSKQYFIKKRKMLSEYRKNVRFVYQ 515
            RL N LK  K   W   E FYS IDK +F G+N   + +    PNLKT+KL   +W  I++  GKP R S  +F ++R  L + R+ +R + Q
Sbjct:  179 RLRNLLKLPKAHKWCIYEWFYSNIDKPLFEGDNDFCVCLKESFPNLKTRKLTRVEWGKIRRLMGKPRRCSSAFFEEERSALKQKRQKIRLLQQ 271          
BLAST of DIRP domain-containing protein vs. Ensembl Celegans
Match: lin-9 (pep chromosome:WBcel235:III:8900240:8904160:-1 gene:WBGene00002998.1 transcript:ZK637.7a.2 gene_biotype:protein_coding transcript_biotype:protein_coding gene_symbol:lin-9)

HSP 1 Score: 77.411 bits (189), Expect = 4.430e-14
Identity = 85/325 (26.15%), Postives = 144/325 (44.31%), Query Frame = 3
Query:  228 NYNRLSNFLKSKKVFNWISNELFYSEIDKSIFLGNNKLQLYISSYLPNLKTKKLNISQWRIIKKCFGKPIRMSKQYFIKKRKMLSEYRKNVRFVYQIFDCRINKDYEFLKNLKCALKHLPNNLVVNSFSYKKTKNIIMSYKDKVAQFNDGVLNDKYKGLYFVELIDNDSNFPKRLYT----INDTNLSLIRDC----ESNSKFS------VKIINKACQSILSSNI---KKLAYNFNDFIKIFEDERFNSKIFDFSNDNEINPLISHLSKQSMEFKRSLNNKQNWIRQISEIHTLFEDNSNYAD---QEIKEKYAKLLIALSSEN 1142
            N  +L N L+ KK   W+  E FYS ID+ IF   N+    I    PNLK   L   +WR I+K  GKP R SK +F ++R  L E R  +R VY+     +N     LK+L      LP  +VV +  + + +N    Y    +   D V+   ++      +I +  + P  L +    + D  L L+       ++NSK        V  +  +    L  ++   +K+  +    +    DER N K  +   +  +  L++ +     +  + ++ K+  IRQ++E++   E  +  +D   +  +EKYAK +I L   N
Sbjct:  202 NIKKLYNLLRYKKARQWVMCEFFYSAIDEQIFKEENEFATIIRESFPNLKNWNLTRIEWRSIRKLLGKPRRCSKVFFEEERMYLEEKRMKIRSVYE--GSYLNDPSIDLKDLPA---KLPRPMVVGNRVFARIRN---PYDGIYSGIIDAVIPKGFR------IIFDKPDIPPTLVSDTEILLDGKLDLLSIAYFIEQANSKLPSGVRPFVAAVRDSSHPHLVRDVLVSRKIERSGGPLMGP-NDERLNGKNAEMVGNFPLKFLVNLV-----KLTKLIDIKKGLIRQLNELNADAEIQNMTSDKYSKAFQEKYAKTIIDLEHVN 506          
BLAST of DIRP domain-containing protein vs. Ensembl Celegans
Match: lin-9 (pep chromosome:WBcel235:III:8900237:8904131:-1 gene:WBGene00002998.1 transcript:ZK637.7a.1 gene_biotype:protein_coding transcript_biotype:protein_coding gene_symbol:lin-9)

HSP 1 Score: 77.411 bits (189), Expect = 4.430e-14
Identity = 85/325 (26.15%), Postives = 144/325 (44.31%), Query Frame = 3
Query:  228 NYNRLSNFLKSKKVFNWISNELFYSEIDKSIFLGNNKLQLYISSYLPNLKTKKLNISQWRIIKKCFGKPIRMSKQYFIKKRKMLSEYRKNVRFVYQIFDCRINKDYEFLKNLKCALKHLPNNLVVNSFSYKKTKNIIMSYKDKVAQFNDGVLNDKYKGLYFVELIDNDSNFPKRLYT----INDTNLSLIRDC----ESNSKFS------VKIINKACQSILSSNI---KKLAYNFNDFIKIFEDERFNSKIFDFSNDNEINPLISHLSKQSMEFKRSLNNKQNWIRQISEIHTLFEDNSNYAD---QEIKEKYAKLLIALSSEN 1142
            N  +L N L+ KK   W+  E FYS ID+ IF   N+    I    PNLK   L   +WR I+K  GKP R SK +F ++R  L E R  +R VY+     +N     LK+L      LP  +VV +  + + +N    Y    +   D V+   ++      +I +  + P  L +    + D  L L+       ++NSK        V  +  +    L  ++   +K+  +    +    DER N K  +   +  +  L++ +     +  + ++ K+  IRQ++E++   E  +  +D   +  +EKYAK +I L   N
Sbjct:  202 NIKKLYNLLRYKKARQWVMCEFFYSAIDEQIFKEENEFATIIRESFPNLKNWNLTRIEWRSIRKLLGKPRRCSKVFFEEERMYLEEKRMKIRSVYE--GSYLNDPSIDLKDLPA---KLPRPMVVGNRVFARIRN---PYDGIYSGIIDAVIPKGFR------IIFDKPDIPPTLVSDTEILLDGKLDLLSIAYFIEQANSKLPSGVRPFVAAVRDSSHPHLVRDVLVSRKIERSGGPLMGP-NDERLNGKNAEMVGNFPLKFLVNLV-----KLTKLIDIKKGLIRQLNELNADAEIQNMTSDKYSKAFQEKYAKTIIDLEHVN 506          
BLAST of DIRP domain-containing protein vs. Ensembl Celegans
Match: lin-9 (pep chromosome:WBcel235:III:8900237:8904131:-1 gene:WBGene00002998.1 transcript:ZK637.7b.2 gene_biotype:protein_coding transcript_biotype:protein_coding gene_symbol:lin-9)

HSP 1 Score: 77.0258 bits (188), Expect = 4.639e-14
Identity = 85/325 (26.15%), Postives = 144/325 (44.31%), Query Frame = 3
Query:  228 NYNRLSNFLKSKKVFNWISNELFYSEIDKSIFLGNNKLQLYISSYLPNLKTKKLNISQWRIIKKCFGKPIRMSKQYFIKKRKMLSEYRKNVRFVYQIFDCRINKDYEFLKNLKCALKHLPNNLVVNSFSYKKTKNIIMSYKDKVAQFNDGVLNDKYKGLYFVELIDNDSNFPKRLYT----INDTNLSLIRDC----ESNSKFS------VKIINKACQSILSSNI---KKLAYNFNDFIKIFEDERFNSKIFDFSNDNEINPLISHLSKQSMEFKRSLNNKQNWIRQISEIHTLFEDNSNYAD---QEIKEKYAKLLIALSSEN 1142
            N  +L N L+ KK   W+  E FYS ID+ IF   N+    I    PNLK   L   +WR I+K  GKP R SK +F ++R  L E R  +R VY+     +N     LK+L      LP  +VV +  + + +N    Y    +   D V+   ++      +I +  + P  L +    + D  L L+       ++NSK        V  +  +    L  ++   +K+  +    +    DER N K  +   +  +  L++ +     +  + ++ K+  IRQ++E++   E  +  +D   +  +EKYAK +I L   N
Sbjct:  204 NIKKLYNLLRYKKARQWVMCEFFYSAIDEQIFKEENEFATIIRESFPNLKNWNLTRIEWRSIRKLLGKPRRCSKVFFEEERMYLEEKRMKIRSVYE--GSYLNDPSIDLKDLPA---KLPRPMVVGNRVFARIRN---PYDGIYSGIIDAVIPKGFR------IIFDKPDIPPTLVSDTEILLDGKLDLLSIAYFIEQANSKLPSGVRPFVAAVRDSSHPHLVRDVLVSRKIERSGGPLMGP-NDERLNGKNAEMVGNFPLKFLVNLV-----KLTKLIDIKKGLIRQLNELNADAEIQNMTSDKYSKAFQEKYAKTIIDLEHVN 508          
BLAST of DIRP domain-containing protein vs. Ensembl Celegans
Match: lin-9 (pep chromosome:WBcel235:III:8900238:8904160:-1 gene:WBGene00002998.1 transcript:ZK637.7b.1 gene_biotype:protein_coding transcript_biotype:protein_coding gene_symbol:lin-9)

HSP 1 Score: 77.0258 bits (188), Expect = 4.639e-14
Identity = 85/325 (26.15%), Postives = 144/325 (44.31%), Query Frame = 3
Query:  228 NYNRLSNFLKSKKVFNWISNELFYSEIDKSIFLGNNKLQLYISSYLPNLKTKKLNISQWRIIKKCFGKPIRMSKQYFIKKRKMLSEYRKNVRFVYQIFDCRINKDYEFLKNLKCALKHLPNNLVVNSFSYKKTKNIIMSYKDKVAQFNDGVLNDKYKGLYFVELIDNDSNFPKRLYT----INDTNLSLIRDC----ESNSKFS------VKIINKACQSILSSNI---KKLAYNFNDFIKIFEDERFNSKIFDFSNDNEINPLISHLSKQSMEFKRSLNNKQNWIRQISEIHTLFEDNSNYAD---QEIKEKYAKLLIALSSEN 1142
            N  +L N L+ KK   W+  E FYS ID+ IF   N+    I    PNLK   L   +WR I+K  GKP R SK +F ++R  L E R  +R VY+     +N     LK+L      LP  +VV +  + + +N    Y    +   D V+   ++      +I +  + P  L +    + D  L L+       ++NSK        V  +  +    L  ++   +K+  +    +    DER N K  +   +  +  L++ +     +  + ++ K+  IRQ++E++   E  +  +D   +  +EKYAK +I L   N
Sbjct:  204 NIKKLYNLLRYKKARQWVMCEFFYSAIDEQIFKEENEFATIIRESFPNLKNWNLTRIEWRSIRKLLGKPRRCSKVFFEEERMYLEEKRMKIRSVYE--GSYLNDPSIDLKDLPA---KLPRPMVVGNRVFARIRN---PYDGIYSGIIDAVIPKGFR------IIFDKPDIPPTLVSDTEILLDGKLDLLSIAYFIEQANSKLPSGVRPFVAAVRDSSHPHLVRDVLVSRKIERSGGPLMGP-NDERLNGKNAEMVGNFPLKFLVNLV-----KLTKLIDIKKGLIRQLNELNADAEIQNMTSDKYSKAFQEKYAKTIIDLEHVN 508          
BLAST of DIRP domain-containing protein vs. Ensembl Zebrafish
Match: lin9 (lin-9 DREAM MuvB core complex component [Source:NCBI gene;Acc:560867])

HSP 1 Score: 77.7962 bits (190), Expect = 3.195e-14
Identity = 41/104 (39.42%), Postives = 57/104 (54.81%), Query Frame = 3
Query:  237 RLSNFLKSKKVFNWISNELFYSEIDKSIFLGNNKLQLYISSYLPNLKTKKLNISQWRIIKKCFGKPIRMSKQYFIKKRKMLSEYRKNVRFVYQ--IFDCRINKD 542
            RL N LK  K   W   E FYS ID+ +F G+N   L +    PNLKT+KL   +W  I++  GKP R S  +F ++R  L + R+ +R + Q  I D  + KD
Sbjct:   57 RLRNLLKLPKAHKWCIYEWFYSNIDRPLFEGDNDFCLCLKESFPNLKTRKLTRVEWGTIRRLMGKPRRCSSAFFAEERMALKQKRQKMRLLQQRKITDMSLCKD 160          
BLAST of DIRP domain-containing protein vs. Ensembl Zebrafish
Match: lin9 (lin-9 DREAM MuvB core complex component [Source:NCBI gene;Acc:560867])

HSP 1 Score: 78.1814 bits (191), Expect = 3.524e-14
Identity = 41/104 (39.42%), Postives = 57/104 (54.81%), Query Frame = 3
Query:  237 RLSNFLKSKKVFNWISNELFYSEIDKSIFLGNNKLQLYISSYLPNLKTKKLNISQWRIIKKCFGKPIRMSKQYFIKKRKMLSEYRKNVRFVYQ--IFDCRINKD 542
            RL N LK  K   W   E FYS ID+ +F G+N   L +    PNLKT+KL   +W  I++  GKP R S  +F ++R  L + R+ +R + Q  I D  + KD
Sbjct:  106 RLRNLLKLPKAHKWCIYEWFYSNIDRPLFEGDNDFCLCLKESFPNLKTRKLTRVEWGTIRRLMGKPRRCSSAFFAEERMALKQKRQKMRLLQQRKITDMSLCKD 209          
BLAST of DIRP domain-containing protein vs. Ensembl Xenopus
Match: LIN9 (lin-9 DREAM MuvB core complex component [Source:NCBI gene;Acc:100491065])

HSP 1 Score: 75.485 bits (184), Expect = 2.492e-13
Identity = 44/133 (33.08%), Postives = 67/133 (50.38%), Query Frame = 3
Query:  237 RLSNFLKSKKVFNWISNELFYSEIDKSIFLGNNKLQLYISSYLPNLKTKKLNISQWRIIKKCFGKPIRMSKQYFIKKRKMLSEYRKNVRFVYQIFDCRINKDYEFLKNLKCALKHLPNNLVVNSFSYKKTKNI 635
            RL N LK  K   W   E FYS IDK +F G+N   + +    PNLKT+KL   +W  I++  GKP R S  +F ++R  L + R+ +R + Q    R   D    K+L      +P +LV+ +    + + +
Sbjct:   34 RLRNLLKLPKAHKWCIYEWFYSNIDKPLFEGDNDFCVCLKESFPNLKTRKLTRVEWGKIRRLMGKPRRCSAAFFEEERSALEQKRQKIRLLQQ----RKVADVSQFKDLP---DEIPLSLVIGTKVTARLRGV 159          
BLAST of DIRP domain-containing protein vs. Ensembl Xenopus
Match: LIN9 (lin-9 DREAM MuvB core complex component [Source:NCBI gene;Acc:100491065])

HSP 1 Score: 75.0998 bits (183), Expect = 3.615e-13
Identity = 44/124 (35.48%), Postives = 64/124 (51.61%), Query Frame = 3
Query:  237 RLSNFLKSKKVFNWISNELFYSEIDKSIFLGNNKLQLYISSYLPNLKTKKLNISQWRIIKKCFGKPIRMSKQYFIKKRKMLSEYRKNVRFVYQIFDCRINKDYEFLKNLKCALKHLPNNLVVNS 608
            RL N LK  K   W   E FYS IDK +F G+N   + +    PNLKT+KL   +W  I++  GKP R S  +F ++R  L + R+ +R + Q    R   D    K+L      +P +LV+ +
Sbjct:   92 RLRNLLKLPKAHKWCIYEWFYSNIDKPLFEGDNDFCVCLKESFPNLKTRKLTRVEWGKIRRLMGKPRRCSAAFFEEERSALEQKRQKIRLLQQ----RKVADVSQFKDLP---DEIPLSLVIGT 208          
BLAST of DIRP domain-containing protein vs. Ensembl Xenopus
Match: LIN9 (lin-9 DREAM MuvB core complex component [Source:NCBI gene;Acc:100491065])

HSP 1 Score: 75.0998 bits (183), Expect = 4.284e-13
Identity = 44/124 (35.48%), Postives = 64/124 (51.61%), Query Frame = 3
Query:  237 RLSNFLKSKKVFNWISNELFYSEIDKSIFLGNNKLQLYISSYLPNLKTKKLNISQWRIIKKCFGKPIRMSKQYFIKKRKMLSEYRKNVRFVYQIFDCRINKDYEFLKNLKCALKHLPNNLVVNS 608
            RL N LK  K   W   E FYS IDK +F G+N   + +    PNLKT+KL   +W  I++  GKP R S  +F ++R  L + R+ +R + Q    R   D    K+L      +P +LV+ +
Sbjct:  114 RLRNLLKLPKAHKWCIYEWFYSNIDKPLFEGDNDFCVCLKESFPNLKTRKLTRVEWGKIRRLMGKPRRCSAAFFEEERSALEQKRQKIRLLQQ----RKVADVSQFKDLP---DEIPLSLVIGT 230          
BLAST of DIRP domain-containing protein vs. Ensembl Xenopus
Match: LIN9 (lin-9 DREAM MuvB core complex component [Source:NCBI gene;Acc:100491065])

HSP 1 Score: 75.0998 bits (183), Expect = 4.454e-13
Identity = 44/124 (35.48%), Postives = 64/124 (51.61%), Query Frame = 3
Query:  237 RLSNFLKSKKVFNWISNELFYSEIDKSIFLGNNKLQLYISSYLPNLKTKKLNISQWRIIKKCFGKPIRMSKQYFIKKRKMLSEYRKNVRFVYQIFDCRINKDYEFLKNLKCALKHLPNNLVVNS 608
            RL N LK  K   W   E FYS IDK +F G+N   + +    PNLKT+KL   +W  I++  GKP R S  +F ++R  L + R+ +R + Q    R   D    K+L      +P +LV+ +
Sbjct:  127 RLRNLLKLPKAHKWCIYEWFYSNIDKPLFEGDNDFCVCLKESFPNLKTRKLTRVEWGKIRRLMGKPRRCSAAFFEEERSALEQKRQKIRLLQQ----RKVADVSQFKDLP---DEIPLSLVIGT 243          
BLAST of DIRP domain-containing protein vs. Ensembl Xenopus
Match: LIN9 (lin-9 DREAM MuvB core complex component [Source:NCBI gene;Acc:100491065])

HSP 1 Score: 74.7146 bits (182), Expect = 4.921e-13
Identity = 44/124 (35.48%), Postives = 64/124 (51.61%), Query Frame = 3
Query:  237 RLSNFLKSKKVFNWISNELFYSEIDKSIFLGNNKLQLYISSYLPNLKTKKLNISQWRIIKKCFGKPIRMSKQYFIKKRKMLSEYRKNVRFVYQIFDCRINKDYEFLKNLKCALKHLPNNLVVNS 608
            RL N LK  K   W   E FYS IDK +F G+N   + +    PNLKT+KL   +W  I++  GKP R S  +F ++R  L + R+ +R + Q    R   D    K+L      +P +LV+ +
Sbjct:  107 RLRNLLKLPKAHKWCIYEWFYSNIDKPLFEGDNDFCVCLKESFPNLKTRKLTRVEWGKIRRLMGKPRRCSAAFFEEERSALEQKRQKIRLLQQ----RKVADVSQFKDLP---DEIPLSLVIGT 223          
BLAST of DIRP domain-containing protein vs. Ensembl Mouse
Match: Lin9 (lin-9 homolog (C. elegans) [Source:MGI Symbol;Acc:MGI:1919818])

HSP 1 Score: 73.9442 bits (180), Expect = 9.989e-14
Identity = 45/133 (33.83%), Postives = 66/133 (49.62%), Query Frame = 3
Query:  237 RLSNFLKSKKVFNWISNELFYSEIDKSIFLGNNKLQLYISSYLPNLKTKKLNISQWRIIKKCFGKPIRMSKQYFIKKRKMLSEYRKNVRFVYQIFDCRINKDYEFLKNLKCALKHLPNNLVVNSFSYKKTKNI 635
            RL N LK  K   W   E FYS IDK +F G+N   + +    PNLKT+KL   +W  I++  GKP R S  +F ++R  L + R+ +R + Q    R   D    K+L      +P  LV+ +    + + I
Sbjct:  108 RLRNLLKLPKAHKWCIYEWFYSNIDKPLFEGDNDFCVCLKESFPNLKTRKLTRVEWGKIRRLMGKPRRCSSAFFEEERSALKQKRQKIRLLQQ----RKVADVSQFKDLP---DEIPLPLVIGTKVTARLRGI 233          
BLAST of DIRP domain-containing protein vs. Ensembl Mouse
Match: Lin9 (lin-9 homolog (C. elegans) [Source:MGI Symbol;Acc:MGI:1919818])

HSP 1 Score: 74.7146 bits (182), Expect = 3.659e-13
Identity = 45/133 (33.83%), Postives = 66/133 (49.62%), Query Frame = 3
Query:  237 RLSNFLKSKKVFNWISNELFYSEIDKSIFLGNNKLQLYISSYLPNLKTKKLNISQWRIIKKCFGKPIRMSKQYFIKKRKMLSEYRKNVRFVYQIFDCRINKDYEFLKNLKCALKHLPNNLVVNSFSYKKTKNI 635
            RL N LK  K   W   E FYS IDK +F G+N   + +    PNLKT+KL   +W  I++  GKP R S  +F ++R  L + R+ +R + Q    R   D    K+L      +P  LV+ +    + + I
Sbjct:   84 RLRNLLKLPKAHKWCIYEWFYSNIDKPLFEGDNDFCVCLKESFPNLKTRKLTRVEWGKIRRLMGKPRRCSSAFFEEERSALKQKRQKIRLLQQ----RKVADVSQFKDLP---DEIPLPLVIGTKVTARLRGI 209          
BLAST of DIRP domain-containing protein vs. Ensembl Mouse
Match: Lin9 (lin-9 homolog (C. elegans) [Source:MGI Symbol;Acc:MGI:1919818])

HSP 1 Score: 74.7146 bits (182), Expect = 4.775e-13
Identity = 37/93 (39.78%), Postives = 52/93 (55.91%), Query Frame = 3
Query:  237 RLSNFLKSKKVFNWISNELFYSEIDKSIFLGNNKLQLYISSYLPNLKTKKLNISQWRIIKKCFGKPIRMSKQYFIKKRKMLSEYRKNVRFVYQ 515
            RL N LK  K   W   E FYS IDK +F G+N   + +    PNLKT+KL   +W  I++  GKP R S  +F ++R  L + R+ +R + Q
Sbjct:  124 RLRNLLKLPKAHKWCIYEWFYSNIDKPLFEGDNDFCVCLKESFPNLKTRKLTRVEWGKIRRLMGKPRRCSSAFFEEERSALKQKRQKIRLLQQ 216          
BLAST of DIRP domain-containing protein vs. UniProt/SwissProt
Match: sp|Q5RHQ8|LIN9_DANRE (Protein lin-9 homolog OS=Danio rerio OX=7955 GN=lin9 PE=3 SV=1)

HSP 1 Score: 78.1814 bits (191), Expect = 2.660e-13
Identity = 41/104 (39.42%), Postives = 57/104 (54.81%), Query Frame = 3
Query:  237 RLSNFLKSKKVFNWISNELFYSEIDKSIFLGNNKLQLYISSYLPNLKTKKLNISQWRIIKKCFGKPIRMSKQYFIKKRKMLSEYRKNVRFVYQ--IFDCRINKD 542
            RL N LK  K   W   E FYS ID+ +F G+N   L +    PNLKT+KL   +W  I++  GKP R S  +F ++R  L + R+ +R + Q  I D  + KD
Sbjct:  106 RLRNLLKLPKAHKWCIYEWFYSNIDRPLFEGDNDFCLCLKESFPNLKTRKLTRVEWGTIRRLMGKPRRCSSAFFAEERMALKQKRQKMRLLQQRKITDMSLCKD 209          
BLAST of DIRP domain-containing protein vs. UniProt/SwissProt
Match: sp|P30630|LIN9_CAEEL (Protein lin-9 OS=Caenorhabditis elegans OX=6239 GN=lin-9 PE=1 SV=3)

HSP 1 Score: 77.0258 bits (188), Expect = 5.901e-13
Identity = 85/325 (26.15%), Postives = 144/325 (44.31%), Query Frame = 3
Query:  228 NYNRLSNFLKSKKVFNWISNELFYSEIDKSIFLGNNKLQLYISSYLPNLKTKKLNISQWRIIKKCFGKPIRMSKQYFIKKRKMLSEYRKNVRFVYQIFDCRINKDYEFLKNLKCALKHLPNNLVVNSFSYKKTKNIIMSYKDKVAQFNDGVLNDKYKGLYFVELIDNDSNFPKRLYT----INDTNLSLIRDC----ESNSKFS------VKIINKACQSILSSNI---KKLAYNFNDFIKIFEDERFNSKIFDFSNDNEINPLISHLSKQSMEFKRSLNNKQNWIRQISEIHTLFEDNSNYAD---QEIKEKYAKLLIALSSEN 1142
            N  +L N L+ KK   W+  E FYS ID+ IF   N+    I    PNLK   L   +WR I+K  GKP R SK +F ++R  L E R  +R VY+     +N     LK+L      LP  +VV +  + + +N    Y    +   D V+   ++      +I +  + P  L +    + D  L L+       ++NSK        V  +  +    L  ++   +K+  +    +    DER N K  +   +  +  L++ +     +  + ++ K+  IRQ++E++   E  +  +D   +  +EKYAK +I L   N
Sbjct:  204 NIKKLYNLLRYKKARQWVMCEFFYSAIDEQIFKEENEFATIIRESFPNLKNWNLTRIEWRSIRKLLGKPRRCSKVFFEEERMYLEEKRMKIRSVYE--GSYLNDPSIDLKDLPA---KLPRPMVVGNRVFARIRN---PYDGIYSGIIDAVIPKGFR------IIFDKPDIPPTLVSDTEILLDGKLDLLSIAYFIEQANSKLPSGVRPFVAAVRDSSHPHLVRDVLVSRKIERSGGPLMGP-NDERLNGKNAEMVGNFPLKFLVNLV-----KLTKLIDIKKGLIRQLNELNADAEIQNMTSDKYSKAFQEKYAKTIIDLEHVN 508          
BLAST of DIRP domain-containing protein vs. UniProt/SwissProt
Match: sp|Q8C735|LIN9_MOUSE (Protein lin-9 homolog OS=Mus musculus OX=10090 GN=Lin9 PE=1 SV=2)

HSP 1 Score: 74.7146 bits (182), Expect = 2.503e-12
Identity = 45/133 (33.83%), Postives = 66/133 (49.62%), Query Frame = 3
Query:  237 RLSNFLKSKKVFNWISNELFYSEIDKSIFLGNNKLQLYISSYLPNLKTKKLNISQWRIIKKCFGKPIRMSKQYFIKKRKMLSEYRKNVRFVYQIFDCRINKDYEFLKNLKCALKHLPNNLVVNSFSYKKTKNI 635
            RL N LK  K   W   E FYS IDK +F G+N   + +    PNLKT+KL   +W  I++  GKP R S  +F ++R  L + R+ +R + Q    R   D    K+L      +P  LV+ +    + + I
Sbjct:  108 RLRNLLKLPKAHKWCIYEWFYSNIDKPLFEGDNDFCVCLKESFPNLKTRKLTRVEWGKIRRLMGKPRRCSSAFFEEERSALKQKRQKIRLLQQ----RKVADVSQFKDLP---DEIPLPLVIGTKVTARLRGI 233          
BLAST of DIRP domain-containing protein vs. UniProt/SwissProt
Match: sp|Q4R8N2|LIN9_MACFA (Protein lin-9 homolog OS=Macaca fascicularis OX=9541 GN=LIN9 PE=2 SV=1)

HSP 1 Score: 74.7146 bits (182), Expect = 2.850e-12
Identity = 37/93 (39.78%), Postives = 52/93 (55.91%), Query Frame = 3
Query:  237 RLSNFLKSKKVFNWISNELFYSEIDKSIFLGNNKLQLYISSYLPNLKTKKLNISQWRIIKKCFGKPIRMSKQYFIKKRKMLSEYRKNVRFVYQ 515
            RL N LK  K   W   E FYS IDK +F G+N   + +    PNLKT+KL   +W  I++  GKP R S  +F ++R  L + R+ +R + Q
Sbjct:  108 RLRNLLKLPKAHKWCIYEWFYSNIDKPLFEGDNDFCVCLKESFPNLKTRKLTRVEWGKIRRLMGKPRRCSSAFFEEERSALKQKRQKIRLLQQ 200          
BLAST of DIRP domain-containing protein vs. UniProt/SwissProt
Match: sp|Q5TKA1|LIN9_HUMAN (Protein lin-9 homolog OS=Homo sapiens OX=9606 GN=LIN9 PE=1 SV=1)

HSP 1 Score: 74.7146 bits (182), Expect = 2.900e-12
Identity = 37/93 (39.78%), Postives = 52/93 (55.91%), Query Frame = 3
Query:  237 RLSNFLKSKKVFNWISNELFYSEIDKSIFLGNNKLQLYISSYLPNLKTKKLNISQWRIIKKCFGKPIRMSKQYFIKKRKMLSEYRKNVRFVYQ 515
            RL N LK  K   W   E FYS IDK +F G+N   + +    PNLKT+KL   +W  I++  GKP R S  +F ++R  L + R+ +R + Q
Sbjct:  108 RLRNLLKLPKAHKWCIYEWFYSNIDKPLFEGDNDFCVCLKESFPNLKTRKLTRVEWGKIRRLMGKPRRCSSAFFEEERSALKQKRQKIRLLQQ 200          
BLAST of DIRP domain-containing protein vs. TrEMBL
Match: A0A0N5A8E7 (DIRP domain-containing protein OS=Syphacia muris OX=451379 PE=4 SV=2)

HSP 1 Score: 98.5969 bits (244), Expect = 3.154e-17
Identity = 70/246 (28.46%), Postives = 118/246 (47.97%), Query Frame = 3
Query:  225 ENYNRLSNFLKSKKVFNWISNELFYSEIDKSIFLGNNKLQLYISSYLPNLKTKKLNISQWRIIKKCFGKPIRMSKQYFIKKRKMLSEYRKNVRFVYQIFDCRINKDYEFLKNLKCALKHLPNNLVVNSFSYKKTKNIIMSYKDKV-AQFNDGVLNDKYKGLYFVELIDNDSNFPKRLYTINDTNLSLIRDCESNSKFSVKIINKAC-----QSILSSNIKKLAYNFNDFIKIFEDERFNSKIFDFS 944
            +N  RL N LK  K   W+  E FYSE+D+ +FLG+N+    +    PNL+ + L   +WR I++  GKP R S+ +  ++R+ L   R  VR +Y+     ++ D     +L   L+ LP  LVV +  Y + +      KD + A   D VL D Y+ ++     D +   P +          +I+D E  S+  V++++ A      ++ + S++ KL  N       F D RF + +  +S
Sbjct:  163 DNLRRLKNVLKLPKARRWVYCEFFYSEVDQQLFLGDNEFSQLLRESFPNLQCRNLRRPEWRAIRRLIGKPRRCSQAFLNEERQALEAKRAKVRQIYEGTVLNLSSD-----SLDLPLR-LPRPLVVGAKIYARVRQP----KDGIYAGTIDAVLPDSYRVVF-----DKEEMIPPQ----------IIKDSEVMSEQKVELLSLAYFLEQNRASMPSSLMKLGSNAQQLTPRFSDSRFRNDLSSYS 383          
BLAST of DIRP domain-containing protein vs. TrEMBL
Match: A0A016WBH1 (DIRP domain-containing protein OS=Ancylostoma ceylanicum OX=53326 GN=Acey_s0874.g2811 PE=4 SV=1)

HSP 1 Score: 94.7449 bits (234), Expect = 7.307e-16
Identity = 48/149 (32.21%), Postives = 79/149 (53.02%), Query Frame = 3
Query:  237 RLSNFLKSKKVFNWISNELFYSEIDKSIFLGNNKLQLYISSYLPNLKTKKLNISQWRIIKKCFGKPIRMSKQYFIKKRKMLSEYRKNVRFVYQIFDCRINKDYEFLKNLKCALKHLPNNLVVNSFSYKKTKNIIMSYKDKVAQFNDGVL 683
            R+ N LK  K   W+  E FYS +D+ +FLG+N+ +  I    PNLKT ++N  +WR++++  GKP R S  +F ++R++L + R+ VR +Y       +  Y  L N  C L  +P NL        K   +I + + +    N+G +
Sbjct:  171 RIRNLLKLPKARRWVICEFFYSGVDEQLFLGDNEFRQLIREAFPNLKTMQMNKQEWRVVRRLLGKPRRCSTTFFDEERRILDQRRRKVRGIY-------DGSYTSLAN--CDLSDMPPNLPAPLVVGMKDGELIGNGETRRRTGNEGAV 310          
BLAST of DIRP domain-containing protein vs. TrEMBL
Match: A0A016WAK3 (DIRP domain-containing protein OS=Ancylostoma ceylanicum OX=53326 GN=Acey_s0874.g2811 PE=4 SV=1)

HSP 1 Score: 94.3597 bits (233), Expect = 8.653e-16
Identity = 48/149 (32.21%), Postives = 79/149 (53.02%), Query Frame = 3
Query:  237 RLSNFLKSKKVFNWISNELFYSEIDKSIFLGNNKLQLYISSYLPNLKTKKLNISQWRIIKKCFGKPIRMSKQYFIKKRKMLSEYRKNVRFVYQIFDCRINKDYEFLKNLKCALKHLPNNLVVNSFSYKKTKNIIMSYKDKVAQFNDGVL 683
            R+ N LK  K   W+  E FYS +D+ +FLG+N+ +  I    PNLKT ++N  +WR++++  GKP R S  +F ++R++L + R+ VR +Y       +  Y  L N  C L  +P NL        K   +I + + +    N+G +
Sbjct:  181 RIRNLLKLPKARRWVICEFFYSGVDEQLFLGDNEFRQLIREAFPNLKTMQMNKQEWRVVRRLLGKPRRCSTTFFDEERRILDQRRRKVRGIY-------DGSYTSLAN--CDLSDMPPNLPAPLVVGMKDGELIGNGETRRRTGNEGAV 320          
BLAST of DIRP domain-containing protein vs. TrEMBL
Match: A0A016WAH4 (DIRP domain-containing protein OS=Ancylostoma ceylanicum OX=53326 GN=Acey_s0874.g2811 PE=4 SV=1)

HSP 1 Score: 94.3597 bits (233), Expect = 8.976e-16
Identity = 48/149 (32.21%), Postives = 79/149 (53.02%), Query Frame = 3
Query:  237 RLSNFLKSKKVFNWISNELFYSEIDKSIFLGNNKLQLYISSYLPNLKTKKLNISQWRIIKKCFGKPIRMSKQYFIKKRKMLSEYRKNVRFVYQIFDCRINKDYEFLKNLKCALKHLPNNLVVNSFSYKKTKNIIMSYKDKVAQFNDGVL 683
            R+ N LK  K   W+  E FYS +D+ +FLG+N+ +  I    PNLKT ++N  +WR++++  GKP R S  +F ++R++L + R+ VR +Y       +  Y  L N  C L  +P NL        K   +I + + +    N+G +
Sbjct:  182 RIRNLLKLPKARRWVICEFFYSGVDEQLFLGDNEFRQLIREAFPNLKTMQMNKQEWRVVRRLLGKPRRCSTTFFDEERRILDQRRRKVRGIY-------DGSYTSLAN--CDLSDMPPNLPAPLVVGMKDGELIGNGETRRRTGNEGAV 321          
BLAST of DIRP domain-containing protein vs. TrEMBL
Match: A0A3P8DFJ5 (DIRP domain-containing protein OS=Heligmosomoides polygyrus OX=6339 GN=HPBE_LOCUS13112 PE=4 SV=1)

HSP 1 Score: 92.8189 bits (229), Expect = 1.210e-15
Identity = 49/144 (34.03%), Postives = 72/144 (50.00%), Query Frame = 3
Query:  228 NYNRLSNFLKSKKVFNWISNELFYSEIDKSIFLGNNKLQLYISSYLPNLKTKKLNISQWRIIKKCFGKPIRMSKQYFIKKRKMLSEYRKNVRFVYQIFDCRINKDYEFLKNLKCALKHLPNNLVVNSFSYKKTKNIIMSYKDKV 659
            N  R+ N LK  K   W+  E FYS +D+ +FLG+N+    I    PNLKT  +N  +WR++++  GKP R S  +F ++R++L + RK VR +Y         D  F     C L  +P NL        K    + S KD +
Sbjct:   73 NLRRIRNLLKLPKARRWVICEFFYSGVDEQLFLGDNEFGQLIREAFPNLKTMLMNKQEWRVVRRLLGKPRRCSTTFFDEERQILDQRRKKVRGIY---------DGSFTSAANCDLSDMPPNLPAPLVVGMKVYARLRSPKDGI 207          
BLAST of DIRP domain-containing protein vs. Ensembl Cavefish
Match: lin9 (lin-9 DREAM MuvB core complex component [Source:NCBI gene;Acc:103022377])

HSP 1 Score: 79.337 bits (194), Expect = 1.063e-14
Identity = 42/104 (40.38%), Postives = 57/104 (54.81%), Query Frame = 3
Query:  237 RLSNFLKSKKVFNWISNELFYSEIDKSIFLGNNKLQLYISSYLPNLKTKKLNISQWRIIKKCFGKPIRMSKQYFIKKRKMLSEYRKNVRFVYQ--IFDCRINKD 542
            RL N LK  K   W   E FYS IDK +F G+N   L +    PNLKT+KL   +W  I++  GKP R S  +F ++R  L + R+ +R + Q  I D  + KD
Sbjct:  106 RLRNLLKLPKAHKWCIYEWFYSNIDKPLFEGDNDFCLCLKESFPNLKTRKLTRVEWGTIRRLMGKPRRCSSAFFAEERTALKQKRQKMRLLQQRKITDISLCKD 209          
BLAST of DIRP domain-containing protein vs. Ensembl Cavefish
Match: lin9 (lin-9 DREAM MuvB core complex component [Source:NCBI gene;Acc:103022377])

HSP 1 Score: 78.9518 bits (193), Expect = 1.178e-14
Identity = 42/104 (40.38%), Postives = 57/104 (54.81%), Query Frame = 3
Query:  237 RLSNFLKSKKVFNWISNELFYSEIDKSIFLGNNKLQLYISSYLPNLKTKKLNISQWRIIKKCFGKPIRMSKQYFIKKRKMLSEYRKNVRFVYQ--IFDCRINKD 542
            RL N LK  K   W   E FYS IDK +F G+N   L +    PNLKT+KL   +W  I++  GKP R S  +F ++R  L + R+ +R + Q  I D  + KD
Sbjct:   68 RLRNLLKLPKAHKWCIYEWFYSNIDKPLFEGDNDFCLCLKESFPNLKTRKLTRVEWGTIRRLMGKPRRCSSAFFAEERTALKQKRQKMRLLQQRKITDISLCKD 171          
BLAST of DIRP domain-containing protein vs. Ensembl Nematostella
Match: EDO39836 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7S8Y2])

HSP 1 Score: 83.1889 bits (204), Expect = 2.054e-16
Identity = 41/126 (32.54%), Postives = 69/126 (54.76%), Query Frame = 3
Query:  231 YNRLSNFLKSKKVFNWISNELFYSEIDKSIFLGNNKLQLYISSYLPNLKTKKLNISQWRIIKKCFGKPIRMSKQYFIKKRKMLSEYRKNVRFVYQIFDCRINKDYEFLKNLKCALKHLPNNLVVNS 608
            +++L N LK  K   W   E FYS +D+++F G+N   + +    PNLK KK+  ++WR +++  GKP R S  +F+++R+ L E RK +R + Q       K    L+  K   + +P  LV+ +
Sbjct:   57 FSKLQNLLKLPKAAKWCYYEWFYSSVDRALFEGDNDFCICLRESFPNLKVKKMRRAEWREVRRLMGKPRRCSPSFFLEERQALQEKRKKIRLLQQ-------KKVTELRRFKDLPEEVPLPLVIGT 175          
BLAST of DIRP domain-containing protein vs. Ensembl Medaka
Match: lin9 (lin-9 DREAM MuvB core complex component [Source:NCBI gene;Acc:101157584])

HSP 1 Score: 78.5666 bits (192), Expect = 1.879e-14
Identity = 37/93 (39.78%), Postives = 53/93 (56.99%), Query Frame = 3
Query:  237 RLSNFLKSKKVFNWISNELFYSEIDKSIFLGNNKLQLYISSYLPNLKTKKLNISQWRIIKKCFGKPIRMSKQYFIKKRKMLSEYRKNVRFVYQ 515
            RL N LK  K   W   E FYS ID+ +F G+N+  L +    PNLKT+KL   +W  I++  GKP R S  +F ++R  L + R+ +R + Q
Sbjct:  109 RLRNLLKLPKAHKWCIYEWFYSNIDRPLFEGDNEFCLCLKESFPNLKTRKLTRVEWGTIRRLMGKPRRCSSAFFAEERTALRQKRQKMRLLQQ 201          
BLAST of DIRP domain-containing protein vs. Planmine SMEST
Match: SMESG000035506.1 (SMESG000035506.1)

HSP 1 Score: 434.106 bits (1115), Expect = 7.028e-144
Identity = 218/218 (100.00%), Postives = 218/218 (100.00%), Query Frame = 3
Query:  210 MSNSFENYNRLSNFLKSKKVFNWISNELFYSEIDKSIFLGNNKLQLYISSYLPNLKTKKLNISQWRIIKKCFGKPIRMSKQYFIKKRKMLSEYRKNVRFVYQIFDCRINKDYEFLKNLKCALKHLPNNLVVNSFSYKKTKNIIMSYKDKVAQFNDGVLNDKYKGLYFVELIDNDSNFPKRLYTINDTNLSLIRDCESNSKFSVKIINKACQSILSSNI 863
            MSNSFENYNRLSNFLKSKKVFNWISNELFYSEIDKSIFLGNNKLQLYISSYLPNLKTKKLNISQWRIIKKCFGKPIRMSKQYFIKKRKMLSEYRKNVRFVYQIFDCRINKDYEFLKNLKCALKHLPNNLVVNSFSYKKTKNIIMSYKDKVAQFNDGVLNDKYKGLYFVELIDNDSNFPKRLYTINDTNLSLIRDCESNSKFSVKIINKACQSILSSNI
Sbjct:    1 MSNSFENYNRLSNFLKSKKVFNWISNELFYSEIDKSIFLGNNKLQLYISSYLPNLKTKKLNISQWRIIKKCFGKPIRMSKQYFIKKRKMLSEYRKNVRFVYQIFDCRINKDYEFLKNLKCALKHLPNNLVVNSFSYKKTKNIIMSYKDKVAQFNDGVLNDKYKGLYFVELIDNDSNFPKRLYTINDTNLSLIRDCESNSKFSVKIINKACQSILSSNI 218          
BLAST of DIRP domain-containing protein vs. Planmine SMEST
Match: SMESG000035510.1 (SMESG000035510.1)

HSP 1 Score: 265.388 bits (677), Expect = 7.628e-82
Identity = 152/160 (95.00%), Postives = 156/160 (97.50%), Query Frame = 3
Query:  993 MEFKRSLNNKQNWIRQISEIHTLFEDNSNYADQEIKEKYAKLLIALSSENLIMKNIMEIILINTHKLSSSYNMTSIRLLSTNVVQKSLDSSADLLLNIMNEEGIKINNRLILEFXXXXXXXXXXXXXXNELTNLEIGNLISSIFKSWGSKYQKRFPYLIP 1472
            MEFKRSLNNKQNWIRQISEIHTLFEDNSNYADQEIKEKYAKLLIALSSENLIMKNIMEIILINTHKLSSSYNM SIRLLSTNVVQKSLDSSADLLLNIMNEEGIKINNRLILEFISKIIGSLIIIQASNELTNLEIGNLISSIFKSWGSKY+K F +++ 
Sbjct:    1 MEFKRSLNNKQNWIRQISEIHTLFEDNSNYADQEIKEKYAKLLIALSSENLIMKNIMEIILINTHKLSSSYNMKSIRLLSTNVVQKSLDSSADLLLNIMNEEGIKINNRLILEFISKIIGSLIIIQASNELTNLEIGNLISSIFKSWGSKYRKDFLFMLE 160          
BLAST of DIRP domain-containing protein vs. Planmine SMEST
Match: SMESG000035506.1 (SMESG000035506.1)

HSP 1 Score: 262.692 bits (670), Expect = 1.878e-81
Identity = 130/130 (100.00%), Postives = 130/130 (100.00%), Query Frame = 3
Query:  474 MLSEYRKNVRFVYQIFDCRINKDYEFLKNLKCALKHLPNNLVVNSFSYKKTKNIIMSYKDKVAQFNDGVLNDKYKGLYFVELIDNDSNFPKRLYTINDTNLSLIRDCESNSKFSVKIINKACQSILSSNI 863
            MLSEYRKNVRFVYQIFDCRINKDYEFLKNLKCALKHLPNNLVVNSFSYKKTKNIIMSYKDKVAQFNDGVLNDKYKGLYFVELIDNDSNFPKRLYTINDTNLSLIRDCESNSKFSVKIINKACQSILSSNI
Sbjct:    1 MLSEYRKNVRFVYQIFDCRINKDYEFLKNLKCALKHLPNNLVVNSFSYKKTKNIIMSYKDKVAQFNDGVLNDKYKGLYFVELIDNDSNFPKRLYTINDTNLSLIRDCESNSKFSVKIINKACQSILSSNI 130          
BLAST of DIRP domain-containing protein vs. Planmine SMEST
Match: SMESG000030984.1 (SMESG000030984.1)

HSP 1 Score: 74.3294 bits (181), Expect = 3.418e-13
Identity = 36/96 (37.50%), Postives = 53/96 (55.21%), Query Frame = 3
Query:  228 NYNRLSNFLKSKKVFNWISNELFYSEIDKSIFLGNNKLQLYISSYLPNLKTKKLNISQWRIIKKCFGKPIRMSKQYFIKKRKMLSEYRKNVRFVYQ 515
            N  +L N LK  K   W+  E FYS +D+ + LG N  ++++    P LKT+KL  +QW  I+K  GKP R S  +F ++R  L   R  +R + Q
Sbjct:   93 NAIKLRNVLKLPKAHKWVFYEWFYSNLDRPLLLGENDFRVFLRETFPALKTRKLTRAQWACIRKMMGKPRRCSYHFFKEERASLHAKRSKIRTLQQ 188          
The following BLAST results are available for this feature:
BLAST of DIRP domain-containing protein vs. Ensembl Human
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Human e!99)
Total hits: 4
Match NameE-valueIdentityDescription
LIN92.122e-1333.85lin-9 DREAM MuvB core complex component [Source:HG... [more]
LIN92.294e-1334.75lin-9 DREAM MuvB core complex component [Source:HG... [more]
LIN97.016e-1339.78lin-9 DREAM MuvB core complex component [Source:HG... [more]
LIN97.224e-1339.78lin-9 DREAM MuvB core complex component [Source:HG... [more]
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BLAST of DIRP domain-containing protein vs. Ensembl Celegans
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99)
Total hits: 4
Match NameE-valueIdentityDescription
lin-94.430e-1426.15pep chromosome:WBcel235:III:8900240:8904160:-1 gen... [more]
lin-94.430e-1426.15pep chromosome:WBcel235:III:8900237:8904131:-1 gen... [more]
lin-94.639e-1426.15pep chromosome:WBcel235:III:8900237:8904131:-1 gen... [more]
lin-94.639e-1426.15pep chromosome:WBcel235:III:8900238:8904160:-1 gen... [more]
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BLAST of DIRP domain-containing protein vs. Ensembl Fly
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99)
Total hits: 0
Match NameE-valueIdentityDescription
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BLAST of DIRP domain-containing protein vs. Ensembl Zebrafish
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99)
Total hits: 2
Match NameE-valueIdentityDescription
lin93.195e-1439.42lin-9 DREAM MuvB core complex component [Source:NC... [more]
lin93.524e-1439.42lin-9 DREAM MuvB core complex component [Source:NC... [more]
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BLAST of DIRP domain-containing protein vs. Ensembl Xenopus
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99)
Total hits: 5
Match NameE-valueIdentityDescription
LIN92.492e-1333.08lin-9 DREAM MuvB core complex component [Source:NC... [more]
LIN93.615e-1335.48lin-9 DREAM MuvB core complex component [Source:NC... [more]
LIN94.284e-1335.48lin-9 DREAM MuvB core complex component [Source:NC... [more]
LIN94.454e-1335.48lin-9 DREAM MuvB core complex component [Source:NC... [more]
LIN94.921e-1335.48lin-9 DREAM MuvB core complex component [Source:NC... [more]
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BLAST of DIRP domain-containing protein vs. Ensembl Mouse
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99)
Total hits: 3
Match NameE-valueIdentityDescription
Lin99.989e-1433.83lin-9 homolog (C. elegans) [Source:MGI Symbol;Acc:... [more]
Lin93.659e-1333.83lin-9 homolog (C. elegans) [Source:MGI Symbol;Acc:... [more]
Lin94.775e-1339.78lin-9 homolog (C. elegans) [Source:MGI Symbol;Acc:... [more]
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BLAST of DIRP domain-containing protein vs. UniProt/SwissProt
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt)
Total hits: 5
Match NameE-valueIdentityDescription
sp|Q5RHQ8|LIN9_DANRE2.660e-1339.42Protein lin-9 homolog OS=Danio rerio OX=7955 GN=li... [more]
sp|P30630|LIN9_CAEEL5.901e-1326.15Protein lin-9 OS=Caenorhabditis elegans OX=6239 GN... [more]
sp|Q8C735|LIN9_MOUSE2.503e-1233.83Protein lin-9 homolog OS=Mus musculus OX=10090 GN=... [more]
sp|Q4R8N2|LIN9_MACFA2.850e-1239.78Protein lin-9 homolog OS=Macaca fascicularis OX=95... [more]
sp|Q5TKA1|LIN9_HUMAN2.900e-1239.78Protein lin-9 homolog OS=Homo sapiens OX=9606 GN=L... [more]
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BLAST of DIRP domain-containing protein vs. TrEMBL
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL)
Total hits: 5
Match NameE-valueIdentityDescription
A0A0N5A8E73.154e-1728.46DIRP domain-containing protein OS=Syphacia muris O... [more]
A0A016WBH17.307e-1632.21DIRP domain-containing protein OS=Ancylostoma ceyl... [more]
A0A016WAK38.653e-1632.21DIRP domain-containing protein OS=Ancylostoma ceyl... [more]
A0A016WAH48.976e-1632.21DIRP domain-containing protein OS=Ancylostoma ceyl... [more]
A0A3P8DFJ51.210e-1534.03DIRP domain-containing protein OS=Heligmosomoides ... [more]
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BLAST of DIRP domain-containing protein vs. Ensembl Cavefish
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99)
Total hits: 2
Match NameE-valueIdentityDescription
lin91.063e-1440.38lin-9 DREAM MuvB core complex component [Source:NC... [more]
lin91.178e-1440.38lin-9 DREAM MuvB core complex component [Source:NC... [more]
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BLAST of DIRP domain-containing protein vs. Ensembl Sea Lamprey
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99)
Total hits: 0
Match NameE-valueIdentityDescription
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BLAST of DIRP domain-containing protein vs. Ensembl Yeast
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46)
Total hits: 0
Match NameE-valueIdentityDescription
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BLAST of DIRP domain-containing protein vs. Ensembl Nematostella
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46)
Total hits: 1
Match NameE-valueIdentityDescription
EDO398362.054e-1632.54Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7... [more]
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BLAST of DIRP domain-containing protein vs. Ensembl Medaka
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99)
Total hits: 1
Match NameE-valueIdentityDescription
lin91.879e-1439.78lin-9 DREAM MuvB core complex component [Source:NC... [more]
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BLAST of DIRP domain-containing protein vs. Planmine SMEST
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST)
Total hits: 4
Match NameE-valueIdentityDescription
SMESG000035506.17.028e-144100.00SMESG000035506.1[more]
SMESG000035510.17.628e-8295.00SMESG000035510.1[more]
SMESG000035506.11.878e-81100.00SMESG000035506.1[more]
SMESG000030984.13.418e-1337.50SMESG000030984.1[more]
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Sequences
The following sequences are available for this feature:

transcript sequence

>SMED30012517 ID=SMED30012517|Name=DIRP domain-containing protein|organism=Schmidtea mediterranea sexual|type=transcript|length=3708bp
TTCCGATCTCCCAACACAACTGTGGTTTACCCAACACTAACACAAGAATG
TTATGGTATTGTGTTTGATATTATTTATTTTGTTTATATAGAATTTCCGA
AAATACAAAGCAGAAATCTTATTACTTTCTGAGAACTTTTAAAAAACCCT
TGTTTTATTATTTCAATAAATATTAAAGTACGTTCATAGATCTCACTTTT
CAATTGAAAATGTCCAATAGTTTTGAAAATTATAATCGTCTTTCTAACTT
TTTAAAATCGAAAAAAGTATTTAATTGGATTTCTAACGAATTATTTTATT
CAGAAATCGATAAATCTATATTTTTGGGTAACAATAAATTACAACTATAT
ATTTCATCGTATTTACCAAATCTGAAAACGAAAAAACTAAACATATCTCA
ATGGCGTATTATTAAGAAATGCTTTGGTAAACCAATTCGAATGAGCAAGC
AATATTTTATTAAAAAACGCAAAATGCTCTCAGAATATAGAAAAAATGTG
CGATTTGTTTATCAAATATTCGATTGTCGAATAAATAAAGATTATGAATT
TTTAAAAAATCTTAAATGTGCCCTGAAACACTTGCCAAATAATTTAGTTG
TCAATTCTTTCTCTTATAAAAAGACAAAAAATATAATTATGTCATACAAA
GATAAAGTTGCTCAATTTAACGATGGAGTTTTGAATGATAAATACAAAGG
ATTATATTTTGTTGAGTTAATAGATAATGATTCAAATTTTCCCAAACGGC
TATATACAATTAATGATACTAACCTCTCGCTTATTCGTGATTGTGAAAGT
AATTCAAAATTTTCAGTTAAAATAATTAATAAAGCCTGCCAGTCAATTTT
ATCGTCAAATATAAAGAAATTAGCTTACAATTTCAATGATTTTATCAAAA
TATTTGAAGATGAACGCTTTAATTCGAAAATATTTGATTTTTCTAATGAC
AATGAGATTAATCCTTTAATTTCTCACTTGTCTAAGCAGTCGATGGAATT
TAAAAGAAGTCTTAATAATAAACAAAATTGGATACGTCAAATTAGTGAAA
TTCATACATTATTTGAAGATAATTCAAATTATGCTGATCAAGAAATAAAA
GAAAAATATGCCAAATTATTAATAGCACTTAGTTCAGAGAATTTAATTAT
GAAAAATATAATGGAAATAATATTAATTAATACGCACAAGTTATCCTCAA
GTTACAATATGACAAGTATTAGACTTTTATCAACAAATGTAGTGCAGAAA
TCACTCGATTCTTCTGCTGATTTATTACTGAATATAATGAACGAAGAGGG
AATCAAAATAAACAATCGATTAATCTTAGAATTCATTTCTAAAATAATTG
GATCTTTAATTATTATTCAGGCATCAAATGAATTGACTAATCTCGAAATT
GGGAATTTAATATCAAGCATTTTTAAATCATGGGGTTCAAAATATCAGAA
ACGATTTCCTTACTTGATTCCATCCACATTAATAAAAGTGTTCCTCTTTA
CAATATCAAAGCTGTCCAGCTTTAATTCCAATCTGCTAATTTCTTGTATA
CTCAACCACAGTTTTGCATTTGAGTGGATTTAATGCTGTGGAGATATGCT
ATTGCCACTATGTTCAAACCGACATCGAGCAACAATGGGGTTTTTTGAAT
CATTTATTCTGACACGTACAAGAGCAGATTTCTTCTCAACAACTACTCCA
AGTCAACAAATTTGGTTATAATTAATTTTTATTTAAAATTAAATTATCTA
TTAAAATTATTCCACTTATTGAATAAATACATATGCTATTCTAACAGCGC
GTATTGAGATACAAAAATTTCTACTGTTTTCTACCATTTCACTCCATTCC
AAATAGAGTTTATTATTGAGAATTTTCGTGCATTTAAAATTTTTATAATT
TCAAAGTTAAAAAAGAAATTGTTCTTTTCAATATTACCAATTTCGAAATT
TAAACATTGTAAAATAACAATTACACATTCTTAATTTAATATAAGCGAGA
ACATTTTATGGCAGATAATAAAATAAATATTTTAATTGATTTATTTAAAA
GTAATATAATATTATAAATTTTAGTTTTACAATATTATAATAAATATATA
TTTTAAACACTCAGAAAATGGATGCCACAGTGAATAATTAGGATTGCTGG
AAATATTTTGGTAGGAAATAGTTAAAAAATTAATCTGTCGAAGCGCATGT
CAAGCGCAAATAATTCTCCATAACAGGCTGACACCCACATCTGGAACCGG
TACATTCATTAAGATTGAAATCAAAATAATTGCAATTTATAACAAAACGC
TTTGAAGAAAATTAAAAAGCCAATCATTAATGAAATAATTTCCAAATCGG
CTACAGTAGATCGCTTGACCGTTAGTGGATTCATTCGAAAAATATTTCAA
TGACTCCAATGGTTATTGTTTTTTCATTTGTACCCCCTTTTTTATTCCGC
ATTTTGGGCAATATAAATATTTTGATAATATTATATAATAGGGATAAATA
TAATAATAATAATTTTTAAAATTTTAATTTCTAAATCTATAATAAATTGC
CAGGTTATTGTAGAGATATTGAAAGAGAAGAATATGAAACAATTAAACAA
AATATTGATTAGAAGATTGGAAATAAAACGGCATGAAAGCATAAAAAGGA
TTTGAAAATTATGATGATTATGAATTTTGATAGCACATACAAGCCAACAT
TAATTAAAAGTAACACAACAAACGCTCCCAGACTGTCACAATACCTTTTT
ACAGGAGACTCGACTGGGCTCGTATATAAAAAAGTAACTGTTAGCCGCAC
GGCCGCACTATAACAATATTATATATTATTATCATAGAAATTCATATTGA
ACTATCACGACAAATTTTAAGCAAATATCATTCAAACAAGGACAGATTAT
TTAATATGAGAAATTTATTGAATTTACAAACTGATTTTAGTGATAACTAT
TAGGAAAATTTCAGTTTAGTTAAAATCAATTATATCTGCTCATAGGAAAT
TTTGATTAAATCAAAGGATGAGAGAGGCTTGCAACAGCTAGATTAAGCTT
TGAAAAGGATCTTGCTGTTACTATGAGTAATAATGAGAGTCTTATATTGG
AATTTCAATTCTACCTGATGATGACAGTGAGCCGGCTGAAATGTATGCAG
TATCAGCTATGTTCGAGTGGAGTTTTCTAATATTTACATCTGCACCATTG
TTATGTGTTTGTTATCATTAATTGTTACGCAACAAATATCGTCGTAATTG
ATATAGATGCGATTAATGCTTTTACTGACATTAAGTCAAGAATTTTAATA
ATTACCTTGTTTTTAATTTATGCATTGCCCACAAGCAACAAAGACGGCAT
TAGACAAGCAGCTAGGATGACTACAGATCCAGAACAATTATTCCAGGAGG
CTTCAAAACGATTGGAAAATTCGTCAAAACCTTGAAGGGCAATCGCAATT
TTGGAACTGACGAAAAAATCAAAAATTATTTATCCAGAAAGCTCAATTGC
AAGTCATTTATTACAAATTTCTGATAACAATTTAATGTAACTCCCAAATA
CATTCATTTTGTGGCCGATACGCTTATTGGAACTCATTCAAGCAACTTTG
GAACTAAGTACGAAATGATTCCACGCTACTAACGTTTGCCAAAAATTCTT
TCAAGCATAGAAAATAGAAGTTTCAACTATCATAATCATGGTCAACCCCC
CAATCCCA
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protein sequence of SMED30012517-orf-1

>SMED30012517-orf-1 ID=SMED30012517-orf-1|Name=SMED30012517-orf-1|organism=Schmidtea mediterranea sexual|type=polypeptide|length=458bp
MSNSFENYNRLSNFLKSKKVFNWISNELFYSEIDKSIFLGNNKLQLYISS
YLPNLKTKKLNISQWRIIKKCFGKPIRMSKQYFIKKRKMLSEYRKNVRFV
YQIFDCRINKDYEFLKNLKCALKHLPNNLVVNSFSYKKTKNIIMSYKDKV
AQFNDGVLNDKYKGLYFVELIDNDSNFPKRLYTINDTNLSLIRDCESNSK
FSVKIINKACQSILSSNIKKLAYNFNDFIKIFEDERFNSKIFDFSNDNEI
NPLISHLSKQSMEFKRSLNNKQNWIRQISEIHTLFEDNSNYADQEIKEKY
AKLLIALSSENLIMKNIMEIILINTHKLSSSYNMTSIRLLSTNVVQKSLD
SSADLLLNIMNEEGIKINNRLILEFISKIIGSLIIIQASNELTNLEIGNL
ISSIFKSWGSKYQKRFPYLIPSTLIKVFLFTISKLSSFNSNLLISCILNH
SFAFEWI*
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Annotated Terms
The following terms have been associated with this transcript:
Vocabulary: Planarian Anatomy
TermDefinition
PLANA:0000099neuron
PLANA:0002109X1 cell
Vocabulary: INTERPRO
TermDefinition
IPR010561LIN-9/ALY1
IPR033471DIRP
IPR006634TLC-dom
Vocabulary: cellular component
TermDefinition
GO:0016021integral component of membrane
GO:0017053transcriptional repressor complex
Vocabulary: biological process
TermDefinition
GO:0006351transcription, DNA-templated
GO:0007049cell cycle
InterPro
Analysis Name: Schmidtea mediteranean smed_20140614 Interproscan
Date Performed: 2020-05-01
IPR TermIPR DescriptionSourceSource TermSource DescriptionAlignment
IPR033471DIRP domainSMARTSM01135DIRP_2coord: 29..110
e-value: 3.3E-9
score: 46.6
IPR033471DIRP domainPFAMPF06584DIRPcoord: 29..130
e-value: 6.5E-20
score: 71.3
IPR010561Protein LIN-9/Protein ALWAYS EARLYPANTHERPTHR21689LIN-9coord: 9..103