Receptor protein serine/threonine kinase

Overview


Name	Receptor protein serine/threonine kinase
Smed ID	SMED30012283
Length (bp)	1665

Neoblast Clusters

Overview

Single cell RNA-seq of pluripotent neoblasts and its early progenies

We isolated X1 neoblasts cells enriched in high piwi-1 expression (Neoblast Population), and profiled ∼7,614 individual cells via scRNA-seq. Unsupervised analyses uncovered 12 distinct classes from 7,088 high-quality cells. We designated these classes Nb1 to Nb12 and ordered them based on high (Nb1) to low (Nb12) piwi-1 expression levels. We further defined groups of genes that best classified the cells parsed into 12 distinct cell clusters to generate a scaled expression heat map of discriminative gene sets for each cluster. Expression of each cluster’s gene signatures was validated using multiplex fluorescence in situ hybridization (FISH) co-stained with piwi-1 and largely confirmed the cell clusters revealed by scRNA-seq.

We also tested sub-lethal irradiation exposure. To profile rare pluripotent stem cells (PSCs) and avoid interference from immediate progenitor cells, we determined a time point after sub-lethal irradiation (7 DPI) with minimal piwi-1+ cells, followed by isolation and single-cell RNA-seq of 1,200 individual cells derived from X1 (Piwi-1 high) and X2 (Piwi-1 low) cell populations (Sub-lethal Irradiated Surviving X1 and X2 Cell Population)

Explore this single cell expression dataset with our NB Cluster Shiny App

Neoblast Population

t-SNE plot shows two-dimensional representation of global gene expression relationships among all neoblasts (n = 7,088 after filter). Cluster identity was assigned based on the top 10 marker genes of each cluster (Table S2), followed by inspection of RNA in situ hybridization patterns. Neoblast groups, Nb.

Expression of Receptor protein serine/threonine kinase (SMED30012283) t-SNE clustered cells

Violin plots show distribution of expression levels for Receptor protein serine/threonine kinase (SMED30012283) in cells (dots) of each of the 12 neoblast clusters.

Embryonic Expression

Davies et. al., 2017

Hover the mouse over a column in the graph to view average RPKM values per sample.
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Embryonic Stages: Y: yolk. S2-S8: Stages 2-8. C4: asexual adult. SX: virgin, sexually mature adult.
For further information about sample preparation and analysis for the single animal RNA-Seq experiment, please refer to the Materials and Methods

Anatomical Expression

PAGE et. al., 2020

SMED30012283

has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGE

PAGE Curations: 7

Expressed In	Reference Transcript	Gene Models	Published Transcript	Transcriptome	Publication
parenchymal cell	SMED30012283	h1SMcG0011750	dd_Smed_v4_53006_0_1	dd_Smed_v4	PMID:29674431 Fincher et al., 2018
oocyte	SMED30012283	h1SMcG0011750	Contig40684	newmark_ests	PMID:28434803 Rouhana et al., 2017
oocyte	SMED30012283	h1SMcG0011750	Contig40684	uc_Smed_v2	PMID:28434803 Rouhana et al., 2017
vitelline gland	SMED30012283	h1SMcG0011750	Contig40684	newmark_ests	PMID:28434803 Rouhana et al., 2017
vitelline gland	SMED30012283	h1SMcG0011750	Contig40684	uc_Smed_v2	PMID:28434803 Rouhana et al., 2017
reproductive organ	SMED30012283	h1SMcG0011750	Contig40684	newmark_ests	PMID:28434803 Rouhana et al., 2017
reproductive organ	SMED30012283	h1SMcG0011750	Contig40684	uc_Smed_v2	PMID:28434803 Rouhana et al., 2017

Note: Hover over icons to view figure legend

Homology

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BLAST of Receptor protein serine/threonine kinase vs. Ensembl Human
Match: ACVR2A (activin A receptor type 2A [Source:HGNC Symbol;Acc:HGNC:173])

HSP 1 Score: 238.81 bits (608), Expect = 1.565e-72
Identity = 128/302 (42.38%), Postives = 187/302 (61.92%), Query Frame = 3

Query:  729 QLLAQGRFGQVWSGIIETRNEHKKQIVAIKIFSDNKEGKKSWRNESTVYSILQNGPHPNILKYFGAERRMKDSITELWLVVEYYPLGSLWNYLKKSTVTWSDLLQICQNIAAGLAHLH----SFSKPINSPIAHRDIKSKNILLKENYTACIADFGLAICHQ--NTDNSFNNRVGTLSYMAPEILEGSINFDIYSFLKIDIFSMSLVFWEVLSRFQFSDLHIKDFQNPFQEIVGENPSFEQLRQCVTIKKLRPAFNENWINLPDVIKFWKTITECWDEDPDARLSAECVLERMNDLCNINSI 1616
            ++ A+GRFG VW    +  NE+    VA+KIF    + K+SW+NE  VYS L    H NIL++ GAE+R      +LWL+  ++  GSL ++LK + V+W++L  I + +A GLA+LH             I+HRDIKSKN+LLK N TACIADFGLA+  +   +    + +VGT  YMAPE+LEG+INF   +FL+ID+++M LV WE+ SR   +D  + ++  PF+E +G++PS E +++ V  KK RP   + W     +    +TI ECWD D +ARLSA CV ER+  +  + +I
Sbjct:   88 EVKARGRFGCVWKA--QLLNEY----VAVKIFP--IQDKQSWQNEYEVYS-LPGMKHENILQFIGAEKRGTSVDVDLWLITAFHEKGSLSDFLKANVVSWNELCHIAETMARGLAYLHEDIPGLKDGHKPAISHRDIKSKNVLLKNNLTACIADFGLALKFEAGKSAGDTHGQVGTRRYMAPEVLEGAINFQRDAFLRIDMYAMGLVLWELASRCTAADGPVDEYMLPFEEEIGQHPSLEDMQEVVVHKKKRPVLRDYWQKHAGMAMLCETIEECWDHDAEARLSAGCVGERITQMQRLTNI 380

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BLAST of Receptor protein serine/threonine kinase vs. Ensembl Human
Match: ACVR2A (activin A receptor type 2A [Source:HGNC Symbol;Acc:HGNC:173])

HSP 1 Score: 238.81 bits (608), Expect = 2.515e-71
Identity = 128/302 (42.38%), Postives = 187/302 (61.92%), Query Frame = 3

Query:  729 QLLAQGRFGQVWSGIIETRNEHKKQIVAIKIFSDNKEGKKSWRNESTVYSILQNGPHPNILKYFGAERRMKDSITELWLVVEYYPLGSLWNYLKKSTVTWSDLLQICQNIAAGLAHLH----SFSKPINSPIAHRDIKSKNILLKENYTACIADFGLAICHQ--NTDNSFNNRVGTLSYMAPEILEGSINFDIYSFLKIDIFSMSLVFWEVLSRFQFSDLHIKDFQNPFQEIVGENPSFEQLRQCVTIKKLRPAFNENWINLPDVIKFWKTITECWDEDPDARLSAECVLERMNDLCNINSI 1616
            ++ A+GRFG VW    +  NE+    VA+KIF    + K+SW+NE  VYS L    H NIL++ GAE+R      +LWL+  ++  GSL ++LK + V+W++L  I + +A GLA+LH             I+HRDIKSKN+LLK N TACIADFGLA+  +   +    + +VGT  YMAPE+LEG+INF   +FL+ID+++M LV WE+ SR   +D  + ++  PF+E +G++PS E +++ V  KK RP   + W     +    +TI ECWD D +ARLSA CV ER+  +  + +I
Sbjct:  196 EVKARGRFGCVWKA--QLLNEY----VAVKIFP--IQDKQSWQNEYEVYS-LPGMKHENILQFIGAEKRGTSVDVDLWLITAFHEKGSLSDFLKANVVSWNELCHIAETMARGLAYLHEDIPGLKDGHKPAISHRDIKSKNVLLKNNLTACIADFGLALKFEAGKSAGDTHGQVGTRRYMAPEVLEGAINFQRDAFLRIDMYAMGLVLWELASRCTAADGPVDEYMLPFEEEIGQHPSLEDMQEVVVHKKKRPVLRDYWQKHAGMAMLCETIEECWDHDAEARLSAGCVGERITQMQRLTNI 488

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BLAST of Receptor protein serine/threonine kinase vs. Ensembl Human
Match: ACVR2A (activin A receptor type 2A [Source:HGNC Symbol;Acc:HGNC:173])

HSP 1 Score: 238.81 bits (608), Expect = 2.515e-71
Identity = 128/302 (42.38%), Postives = 187/302 (61.92%), Query Frame = 3

Query:  729 QLLAQGRFGQVWSGIIETRNEHKKQIVAIKIFSDNKEGKKSWRNESTVYSILQNGPHPNILKYFGAERRMKDSITELWLVVEYYPLGSLWNYLKKSTVTWSDLLQICQNIAAGLAHLH----SFSKPINSPIAHRDIKSKNILLKENYTACIADFGLAICHQ--NTDNSFNNRVGTLSYMAPEILEGSINFDIYSFLKIDIFSMSLVFWEVLSRFQFSDLHIKDFQNPFQEIVGENPSFEQLRQCVTIKKLRPAFNENWINLPDVIKFWKTITECWDEDPDARLSAECVLERMNDLCNINSI 1616
            ++ A+GRFG VW    +  NE+    VA+KIF    + K+SW+NE  VYS L    H NIL++ GAE+R      +LWL+  ++  GSL ++LK + V+W++L  I + +A GLA+LH             I+HRDIKSKN+LLK N TACIADFGLA+  +   +    + +VGT  YMAPE+LEG+INF   +FL+ID+++M LV WE+ SR   +D  + ++  PF+E +G++PS E +++ V  KK RP   + W     +    +TI ECWD D +ARLSA CV ER+  +  + +I
Sbjct:  196 EVKARGRFGCVWKA--QLLNEY----VAVKIFP--IQDKQSWQNEYEVYS-LPGMKHENILQFIGAEKRGTSVDVDLWLITAFHEKGSLSDFLKANVVSWNELCHIAETMARGLAYLHEDIPGLKDGHKPAISHRDIKSKNVLLKNNLTACIADFGLALKFEAGKSAGDTHGQVGTRRYMAPEVLEGAINFQRDAFLRIDMYAMGLVLWELASRCTAADGPVDEYMLPFEEEIGQHPSLEDMQEVVVHKKKRPVLRDYWQKHAGMAMLCETIEECWDHDAEARLSAGCVGERITQMQRLTNI 488

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BLAST of Receptor protein serine/threonine kinase vs. Ensembl Human
Match: ACVR2B (activin A receptor type 2B [Source:HGNC Symbol;Acc:HGNC:174])

HSP 1 Score: 230.335 bits (586), Expect = 3.360e-68
Identity = 117/295 (39.66%), Postives = 186/295 (63.05%), Query Frame = 3

Query:  729 QLLAQGRFGQVWSGIIETRNEHKKQIVAIKIFSDNKEGKKSWRNESTVYSILQNGPHPNILKYFGAERRMKDSITELWLVVEYYPLGSLWNYLKKSTVTWSDLLQICQNIAAGLAHLHS-----FSKPINSPIAHRDIKSKNILLKENYTACIADFGLAICHQ--NTDNSFNNRVGTLSYMAPEILEGSINFDIYSFLKIDIFSMSLVFWEVLSRFQFSDLHIKDFQNPFQEIVGENPSFEQLRQCVTIKKLRPAFNENWINLPDVIKFWKTITECWDEDPDARLSAECVLERMN 1592
            ++ A+GRFG VW      + +     VA+KIF    + K+SW++E  ++S      H N+L++  AE+R  +   ELWL+  ++  GSL +YLK + +TW++L  + + ++ GL++LH        +     IAHRD KSKN+LLK + TA +ADFGLA+  +        + +VGT  YMAPE+LEG+INF   +FL+ID+++M LV WE++SR + +D  + ++  PF+E +G++PS E+L++ V  KK+RP   ++W+  P + +   TI ECWD D +ARLSA CV ER++
Sbjct:  194 EIKARGRFGCVW------KAQLMNDFVAVKIFP--LQDKQSWQSEREIFST-PGMKHENLLQFIAAEKRGSNLEVELWLITAFHDKGSLTDYLKGNIITWNELCHVAETMSRGLSYLHEDVPWCRGEGHKPSIAHRDFKSKNVLLKSDLTAVLADFGLAVRFEPGKPPGDTHGQVGTRRYMAPEVLEGAINFQRDAFLRIDMYAMGLVLWELVSRCKAADGPVDEYMLPFEEEIGQHPSLEELQEVVVHKKMRPTIKDHWLKHPGLAQLCVTIEECWDHDAEARLSAGCVEERVS 479

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BLAST of Receptor protein serine/threonine kinase vs. Ensembl Human
Match: TGFBR2 (transforming growth factor beta receptor 2 [Source:HGNC Symbol;Acc:HGNC:11773])

HSP 1 Score: 214.927 bits (546), Expect = 7.227e-62
Identity = 137/435 (31.49%), Postives = 227/435 (52.18%), Query Frame = 3

Query:  348 CCCKGNLCNDISVKYSIKFPKVYTTINPQSLVMIPNTGQVNIFWIYXXXXXXXXXXXXXXXXXXKRFAIHSKTSINSNRKIFDVEN----INDNVRTPIAKLCENGSRYEENTVLINQISTENLYSLCDKNQLLAQGRFGQVWSGIIETRNEHKKQIVAIKIFSDNKEGKKSWRNESTVYSILQNGPHPNILKYFGAERRMKDSITELWLVVEYYPLGSLWNYLKKSTVTWSDLLQICQNIAAGLAHLHSFSKPINSP---IAHRDIKSKNILLKENYTACIADFGLAICHQNT----DNSFNNRVGTLSYMAPEILEGSINFD-IYSFLKIDIFSMSLVFWEVLSRFQFSDLHIKDFQNPFQEIVGENPSFEQLRQCVTIKKLRPAFNENWINLPDVIKFWKTITECWDEDPDARLSAECVLERMNDLCNINSI 1616
            C C  + CND     +I F + Y T NP  L++I     +++     V +  I +         ++ +  S       RK+ +       I ++ R+ I+  C N   +  NT L+            + + L+ +GRF +V+   ++     + + VA+KIF    E   SW+ E  ++S + N  H NIL++  AE R  +   + WL+  ++  G+L  YL +  ++W DL ++  ++A G+AHLHS   P   P   I HRD+KS NIL+K + T C+ DFGL++    T    D + + +VGT  YMAPE+LE  +N + + SF + D++SM+LV WE+ SR       +KD++ PF   V E+P  E ++  V   + RP     W+N   +    +T+TECWD DP+ARL+A+CV ER ++L +++ +
Sbjct:  136 CSCSSDECND-----NIIFSEEYNTSNPDLLLVIFQVTGISLLPPLGVAISVIIIFYCYRVNRQQKLS--STWETGKTRKLMEFSEHCAIILEDDRSDISSTCANNINH--NTELLP----------IELDTLVGKGRFAEVYKAKLKQNTSEQFETVAVKIFP--YEEYASWKTEKDIFSDI-NLKHENILQFLTAEERKTELGKQYWLITAFHAKGNLQEYLTRHVISWEDLRKLGSSLARGIAHLHSDHTPCGRPKMPIVHRDLKSSNILVKNDLTCCLCDFGLSLRLDPTLSVDDLANSGQVGTARYMAPEVLESRMNLENVESFKQTDVYSMALVLWEMTSRCNAVG-EVKDYEPPFGSKVREHPCVESMKDNVLRDRGRPEIPSFWLNHQGIQMVCETLTECWDHDPEARLTAQCVAERFSELEHLDRL 547

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BLAST of Receptor protein serine/threonine kinase vs. Ensembl Celegans
Match: daf-1 (Cell surface receptor daf-1 [Source:UniProtKB/Swiss-Prot;Acc:P20792])

HSP 1 Score: 171.785 bits (434), Expect = 5.693e-46
Identity = 104/311 (33.44%), Postives = 172/311 (55.31%), Query Frame = 3

Query:  705 LYSLCDKNQLLAQGRFGQVWSGIIETRNEHKKQIVAIKIFSDNKEGKKSWRNESTVYS--ILQNGPHPNILKYFGAERRMKDSITELWLVVEYYPLGSLWNYLKKSTVTWSDLLQICQNIAAGLAHLH---SFSKPINSP-IAHRDIKSKNILLKENYTACIADFGLAICHQNTDNS-----FNNRVGTLSYMAPEILEGSINFDIY-SFLKIDIFSMSLVFWEVLSRFQFSDLHIKDFQN--PFQEIVGENPSFEQLRQCVTIKKLRPAFNENWINLPDVIKFWKTITECWDEDPDARLSAECVLERMND 1595
            L+ L    Q+   GR G    G + +R +++ + VA+K+F  N   + ++  E+ ++   +L+   HPN+L+Y G++R     +TELWLV EY+P GSL ++L ++TV       + ++ A+GLA LH     SK  N P +AHRDIKSKNI++K + T  I D GL++       S      N + GT+ Y+APEIL  ++ F ++ S+   D++S SLV WE L R +  D+  ++     P+ E    +P   Q+   V  ++LRP  N  W + P++    + I  CW+ +P AR ++    +RM++
Sbjct:  284 LHKLTIGGQIRLTGRVGSGRFGNV-SRGDYRGEAVAVKVF--NALDEPAFHKETEIFETRMLR---HPNVLRYIGSDRVDTGFVTELWLVTEYHPSGSLHDFLLENTVNIETYYNLMRSTASGLAFLHNQIGGSKESNKPAMAHRDIKSKNIMVKNDLTCAIGDLGLSLSKPEDAASDIIANENYKCGTVRYLAPEILNSTMQFTVFESYQCADVYSFSLVMWETLCRCEDGDVLPREAATVIPYIEWTDRDPQDAQMFDVVCTRRLRPTENPLWKDHPEMKHIMEIIKTCWNGNPSARFTSYICRKRMDE 588

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BLAST of Receptor protein serine/threonine kinase vs. Ensembl Celegans
Match: daf-1 (Cell surface receptor daf-1 [Source:UniProtKB/Swiss-Prot;Acc:P20792])

HSP 1 Score: 166.777 bits (421), Expect = 3.381e-44
Identity = 104/311 (33.44%), Postives = 171/311 (54.98%), Query Frame = 3

Query:  705 LYSLCDKNQLLAQGRFGQVWSGIIETRNEHKKQIVAIKIFSDNKEGKKSWRNESTVYS--ILQNGPHPNILKYFGAERRMKDSITELWLVVEYYPLGSLWNYLKKSTVTWSDLLQICQNIAAGLAHLH---SFSKPINSP-IAHRDIKSKNILLKENYTACIADFGLAICHQNTDNS-----FNNRVGTLSYMAPEILEGSINFDIY-SFLKIDIFSMSLVFWEVLSRFQFSDLHIKDFQN--PFQEIVGENPSFEQLRQCVTIKKLRPAFNENWINLPDVIKFWKTITECWDEDPDARLSAECVLERMND 1595
            L+ L    Q+   GR G    G + +R +++ + VA+K+F  N   + ++  E+ ++   +L+   HPN+L+Y G++R     +TELWLV EY+P GSL ++L ++TV       + ++ A+GLA LH     SK  N P +AHRDIKSKNI++K + T  I D GL++       S      N + GT  Y+APEIL  ++ F ++ S+   D++S SLV WE L R +  D+  ++     P+ E    +P   Q+   V  ++LRP  N  W + P++    + I  CW+ +P AR ++    +RM++
Sbjct:  284 LHKLTIGGQIRLTGRVGSGRFGNV-SRGDYRGEAVAVKVF--NALDEPAFHKETEIFETRMLR---HPNVLRYIGSDRVDTGFVTELWLVTEYHPSGSLHDFLLENTVNIETYYNLMRSTASGLAFLHNQIGGSKESNKPAMAHRDIKSKNIMVKNDLTCAIGDLGLSLSKPEDAASDIIANENYKCGT-RYLAPEILNSTMQFTVFESYQCADVYSFSLVMWETLCRCEDGDVLPREAATVIPYIEWTDRDPQDAQMFDVVCTRRLRPTENPLWKDHPEMKHIMEIIKTCWNGNPSARFTSYICRKRMDE 587

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BLAST of Receptor protein serine/threonine kinase vs. Ensembl Celegans
Match: daf-4 (Cell surface receptor daf-4 [Source:UniProtKB/Swiss-Prot;Acc:P50488])

HSP 1 Score: 157.918 bits (398), Expect = 8.564e-42
Identity = 110/322 (34.16%), Postives = 172/322 (53.42%), Query Frame = 3

Query:  663 EENTVLINQISTENLYSLCDKNQLLAQGRFGQVWSGIIETRNEHKKQIVAIKIFSDNKEGKKSWRNESTVYSILQNGP--HPNILKYFGAERRMKDSITELWLVVEYYPLGSLWNYLKKSTVTWSDLLQICQNIAAGLAHLHS-----FSKPINSPIAHRDIKSKNILLKENYTACIADFGLA--ICHQNTDNSFNNRVGTLSYMAPEILEGSINFDIYSFLKIDIFSMSLVFWEVLSRFQFSDLHIKD----FQNPFQEIVGENPSFEQLRQCVTIKKLRPAFNENWINLPDVIKFWKTITECWDEDPDARLSAECVLERM 1589
            E    +I  + T     + D  QL+++GRFG+V+     T +  +K++VA+K    N+  K S+  E  ++  L   P  + +I+++  AE+ + D   E W+V E++   SL+  LK + ++ +   +I  ++  GL  LH      F  P   PI HRDIKSKNIL+K + T CIADFGLA    +    +    +VGT  YM+PE+LEG+  F   +F  +D++SM LV WEV+SR   + LH  D    +Q PFQ ++G +P+   +R  V  KK RP + +  I    +    K   E WD +  AR++A C   R+
Sbjct:   70 EPEEEMIEMVETPKELPITD-FQLISKGRFGKVFKAQY-TPDSGEKRLVAVKKL--NEFQKASFLAEKRIFDELNEYPKWYKSIVEFVCAEK-IGD---EYWIVTEFHERLSLYELLKNNVISITSANRIIMSMIDGLQFLHDDRPYFFGHP-KKPIIHRDIKSKNILVKSDMTTCIADFGLARIYSYDIEQSDLLGQVGTKRYMSPEMLEGATEFTPTAFKAMDVYSMGLVMWEVISR---TKLHQTDEPPNYQMPFQ-VIGFDPTIGLMRNYVVSKKERPQWRDEIIKHEYMSLLKKVTEEMWDPEACARITAGCAFARV 378

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BLAST of Receptor protein serine/threonine kinase vs. Ensembl Celegans
Match: daf-4 (Cell surface receptor daf-4 [Source:UniProtKB/Swiss-Prot;Acc:P50488])

HSP 1 Score: 157.918 bits (398), Expect = 2.086e-41
Identity = 110/322 (34.16%), Postives = 172/322 (53.42%), Query Frame = 3

Query:  663 EENTVLINQISTENLYSLCDKNQLLAQGRFGQVWSGIIETRNEHKKQIVAIKIFSDNKEGKKSWRNESTVYSILQNGP--HPNILKYFGAERRMKDSITELWLVVEYYPLGSLWNYLKKSTVTWSDLLQICQNIAAGLAHLHS-----FSKPINSPIAHRDIKSKNILLKENYTACIADFGLA--ICHQNTDNSFNNRVGTLSYMAPEILEGSINFDIYSFLKIDIFSMSLVFWEVLSRFQFSDLHIKD----FQNPFQEIVGENPSFEQLRQCVTIKKLRPAFNENWINLPDVIKFWKTITECWDEDPDARLSAECVLERM 1589
            E    +I  + T     + D  QL+++GRFG+V+     T +  +K++VA+K    N+  K S+  E  ++  L   P  + +I+++  AE+ + D   E W+V E++   SL+  LK + ++ +   +I  ++  GL  LH      F  P   PI HRDIKSKNIL+K + T CIADFGLA    +    +    +VGT  YM+PE+LEG+  F   +F  +D++SM LV WEV+SR   + LH  D    +Q PFQ ++G +P+   +R  V  KK RP + +  I    +    K   E WD +  AR++A C   R+
Sbjct:  137 EPEEEMIEMVETPKELPITD-FQLISKGRFGKVFKAQY-TPDSGEKRLVAVKKL--NEFQKASFLAEKRIFDELNEYPKWYKSIVEFVCAEK-IGD---EYWIVTEFHERLSLYELLKNNVISITSANRIIMSMIDGLQFLHDDRPYFFGHP-KKPIIHRDIKSKNILVKSDMTTCIADFGLARIYSYDIEQSDLLGQVGTKRYMSPEMLEGATEFTPTAFKAMDVYSMGLVMWEVISR---TKLHQTDEPPNYQMPFQ-VIGFDPTIGLMRNYVVSKKERPQWRDEIIKHEYMSLLKKVTEEMWDPEACARITAGCAFARV 445

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BLAST of Receptor protein serine/threonine kinase vs. Ensembl Celegans
Match: daf-4 (Cell surface receptor daf-4 [Source:UniProtKB/Swiss-Prot;Acc:P50488])

HSP 1 Score: 158.688 bits (400), Expect = 3.265e-41
Identity = 109/317 (34.38%), Postives = 171/317 (53.94%), Query Frame = 3

Query:  678 LINQISTENLYSLCDKNQLLAQGRFGQVWSGIIETRNEHKKQIVAIKIFSDNKEGKKSWRNESTVYSILQNGP--HPNILKYFGAERRMKDSITELWLVVEYYPLGSLWNYLKKSTVTWSDLLQICQNIAAGLAHLHS-----FSKPINSPIAHRDIKSKNILLKENYTACIADFGLA--ICHQNTDNSFNNRVGTLSYMAPEILEGSINFDIYSFLKIDIFSMSLVFWEVLSRFQFSDLHIKD----FQNPFQEIVGENPSFEQLRQCVTIKKLRPAFNENWINLPDVIKFWKTITECWDEDPDARLSAECVLERM 1589
            +I  + T     + D  QL+++GRFG+V+     T +  +K++VA+K    N+  K S+  E  ++  L   P  + +I+++  AE+ + D   E W+V E++   SL+  LK + ++ +   +I  ++  GL  LH      F  P   PI HRDIKSKNIL+K + T CIADFGLA    +    +    +VGT  YM+PE+LEG+  F   +F  +D++SM LV WEV+SR   + LH  D    +Q PFQ ++G +P+   +R  V  KK RP + +  I    +    K   E WD +  AR++A C   R+
Sbjct:  273 MIEMVETPKELPITD-FQLISKGRFGKVFKAQY-TPDSGEKRLVAVKKL--NEFQKASFLAEKRIFDELNEYPKWYKSIVEFVCAEK-IGD---EYWIVTEFHERLSLYELLKNNVISITSANRIIMSMIDGLQFLHDDRPYFFGHP-KKPIIHRDIKSKNILVKSDMTTCIADFGLARIYSYDIEQSDLLGQVGTKRYMSPEMLEGATEFTPTAFKAMDVYSMGLVMWEVISR---TKLHQTDEPPNYQMPFQ-VIGFDPTIGLMRNYVVSKKERPQWRDEIIKHEYMSLLKKVTEEMWDPEACARITAGCAFARV 576

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BLAST of Receptor protein serine/threonine kinase vs. Ensembl Fly
Match: put (gene:FBgn0003169 transcript:FBtr0334030)

HSP 1 Score: 236.113 bits (601), Expect = 1.034e-70
Identity = 131/300 (43.67%), Postives = 182/300 (60.67%), Query Frame = 3

Query:  729 QLLAQ---GRFGQVWSGIIETRNEHKKQIVAIKIFSDNKEGKKSWRNESTVYSILQNGPHPNILKYFGAERRMKDSITELWLVVEYYPLGSLWNYLKKSTVTWSDLLQICQNIAAGLAHLH-----SFSKPINSPIAHRDIKSKNILLKENYTACIADFGLAICHQNTD--NSFNNRVGTLSYMAPEILEGSINFDIYSFLKIDIFSMSLVFWEVLSRFQFSDLHIKDFQNPFQEIVGENPSFEQLRQCVTIKKLRPAFNENWINLPDVIKFWKTITECWDEDPDARLSAECVLERMNDL 1598
            QLL Q   GRFG VW   +        Q VA+KIF    + K+SW  E  +Y  L    HPNIL++ G E+ M     E WL+  Y   GSL +YLK  T++W +L +I +++A GLAHLH     S +  +   IAHRD KSKN+LLK + TACIADFGLA+  Q        + +VGT  YMAPE+LEG+INF+  +FL+ID+++  LV WE++SR  F+   + +FQ PF+  +G  PS +++++ V +KKLRP    +W   P +  F  T+ ECWD D +ARLS+ CV+ER   L
Sbjct:  203 QLLEQKASGRFGDVWQAKL------NNQDVAVKIF--RMQEKESWTTEHDIYK-LPRMRHPNILEFLGVEKHMDKP--EYWLISTYQHNGSLCDYLKSHTISWPELCRIAESMANGLAHLHEEIPASKTDGLKPSIAHRDFKSKNVLLKSDLTACIADFGLAMIFQPGKPCGDTHGQVGTRRYMAPEVLEGAINFNRDAFLRIDVYACGLVLWEMVSRCDFAG-PVGEFQLPFEAELGLRPSLDEVQESVVMKKLRPRLLNSWRAHPGLNVFCDTMEECWDHDAEARLSSSCVMERFAQL 490

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BLAST of Receptor protein serine/threonine kinase vs. Ensembl Fly
Match: put (gene:FBgn0003169 transcript:FBtr0082977)

HSP 1 Score: 236.113 bits (601), Expect = 1.034e-70
Identity = 131/300 (43.67%), Postives = 182/300 (60.67%), Query Frame = 3

Query:  729 QLLAQ---GRFGQVWSGIIETRNEHKKQIVAIKIFSDNKEGKKSWRNESTVYSILQNGPHPNILKYFGAERRMKDSITELWLVVEYYPLGSLWNYLKKSTVTWSDLLQICQNIAAGLAHLH-----SFSKPINSPIAHRDIKSKNILLKENYTACIADFGLAICHQNTD--NSFNNRVGTLSYMAPEILEGSINFDIYSFLKIDIFSMSLVFWEVLSRFQFSDLHIKDFQNPFQEIVGENPSFEQLRQCVTIKKLRPAFNENWINLPDVIKFWKTITECWDEDPDARLSAECVLERMNDL 1598
            QLL Q   GRFG VW   +        Q VA+KIF    + K+SW  E  +Y  L    HPNIL++ G E+ M     E WL+  Y   GSL +YLK  T++W +L +I +++A GLAHLH     S +  +   IAHRD KSKN+LLK + TACIADFGLA+  Q        + +VGT  YMAPE+LEG+INF+  +FL+ID+++  LV WE++SR  F+   + +FQ PF+  +G  PS +++++ V +KKLRP    +W   P +  F  T+ ECWD D +ARLS+ CV+ER   L
Sbjct:  203 QLLEQKASGRFGDVWQAKL------NNQDVAVKIF--RMQEKESWTTEHDIYK-LPRMRHPNILEFLGVEKHMDKP--EYWLISTYQHNGSLCDYLKSHTISWPELCRIAESMANGLAHLHEEIPASKTDGLKPSIAHRDFKSKNVLLKSDLTACIADFGLAMIFQPGKPCGDTHGQVGTRRYMAPEVLEGAINFNRDAFLRIDVYACGLVLWEMVSRCDFAG-PVGEFQLPFEAELGLRPSLDEVQESVVMKKLRPRLLNSWRAHPGLNVFCDTMEECWDHDAEARLSSSCVMERFAQL 490

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BLAST of Receptor protein serine/threonine kinase vs. Ensembl Fly
Match: put (gene:FBgn0003169 transcript:FBtr0330227)

HSP 1 Score: 236.113 bits (601), Expect = 1.198e-70
Identity = 131/300 (43.67%), Postives = 182/300 (60.67%), Query Frame = 3

Query:  729 QLLAQ---GRFGQVWSGIIETRNEHKKQIVAIKIFSDNKEGKKSWRNESTVYSILQNGPHPNILKYFGAERRMKDSITELWLVVEYYPLGSLWNYLKKSTVTWSDLLQICQNIAAGLAHLH-----SFSKPINSPIAHRDIKSKNILLKENYTACIADFGLAICHQNTD--NSFNNRVGTLSYMAPEILEGSINFDIYSFLKIDIFSMSLVFWEVLSRFQFSDLHIKDFQNPFQEIVGENPSFEQLRQCVTIKKLRPAFNENWINLPDVIKFWKTITECWDEDPDARLSAECVLERMNDL 1598
            QLL Q   GRFG VW   +        Q VA+KIF    + K+SW  E  +Y  L    HPNIL++ G E+ M     E WL+  Y   GSL +YLK  T++W +L +I +++A GLAHLH     S +  +   IAHRD KSKN+LLK + TACIADFGLA+  Q        + +VGT  YMAPE+LEG+INF+  +FL+ID+++  LV WE++SR  F+   + +FQ PF+  +G  PS +++++ V +KKLRP    +W   P +  F  T+ ECWD D +ARLS+ CV+ER   L
Sbjct:  203 QLLEQKASGRFGDVWQAKL------NNQDVAVKIF--RMQEKESWTTEHDIYK-LPRMRHPNILEFLGVEKHMDKP--EYWLISTYQHNGSLCDYLKSHTISWPELCRIAESMANGLAHLHEEIPASKTDGLKPSIAHRDFKSKNVLLKSDLTACIADFGLAMIFQPGKPCGDTHGQVGTRRYMAPEVLEGAINFNRDAFLRIDVYACGLVLWEMVSRCDFAG-PVGEFQLPFEAELGLRPSLDEVQESVVMKKLRPRLLNSWRAHPGLNVFCDTMEECWDHDAEARLSSSCVMERFAQL 490

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BLAST of Receptor protein serine/threonine kinase vs. Ensembl Fly
Match: sax (gene:FBgn0003317 transcript:FBtr0088833)

HSP 1 Score: 201.445 bits (511), Expect = 1.680e-57
Identity = 109/287 (37.98%), Postives = 173/287 (60.28%), Query Frame = 3

Query:  729 QLLAQGRFGQVWSGIIETRNEHKKQIVAIKIFSDNKEGKKSWRNESTVYSILQNGPHPNILKYFGAERRMKDSITELWLVVEYYPLGSLWNYLKKSTVTWSDLLQICQNIAAGLAHLHS--FSKPINSPIAHRDIKSKNILLKENYTACIADFGLAICHQNTDNSF----NNRVGTLSYMAPEILEGSINFDIYSFL-KIDIFSMSLVFWEVLSRFQFSDLHIKDFQNPFQEIVGENPSFEQLRQCVTIKKLRPAFNENWINLPDVIKFWKTITECWDEDPDARLSA 1568
            + + +G++G+VW G     + H + I A+KIF    E  +SW+ E+ +YS +    H NIL + G++   ++S T+LWL+  YYPLGSL+++L ++ ++ +D++ IC +IA GL HLH+  F K     +AHRD+KSKNIL+  N +  IADFGLA+ H +         N +VGT  YMAPE+L+ SI+ + +  L + DI++  LV WEV  R     +  ++++ PF ++V  +PSFE +R+ V I   RP+    W +   +    K + ECW ++PD RL A
Sbjct:  233 ECIGRGKYGEVWRG-----HWHGESI-AVKIFFSRDE--ESWKRETEIYSTILLR-HENILGFIGSDMTSRNSCTQLWLMTHYYPLGSLFDHLNRNALSHNDMVWICLSIANGLVHLHTEIFGKQGKPAMAHRDLKSKNILVTSNGSCVIADFGLAVTHSHVTGQLDLGNNPKVGTKRYMAPEVLDESIDLECFEALRRTDIYAFGLVLWEVCRRTISCGI-AEEYKVPFYDVVPMDPSFEDMRKVVCIDNYRPSIPNRWSSDSLMTGMSKLMKECWHQNPDVRLPA 509

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BLAST of Receptor protein serine/threonine kinase vs. Ensembl Fly
Match: sax (gene:FBgn0003317 transcript:FBtr0308825)

HSP 1 Score: 201.445 bits (511), Expect = 4.060e-57
Identity = 110/287 (38.33%), Postives = 173/287 (60.28%), Query Frame = 3

Query:  729 QLLAQGRFGQVWSGIIETRNEHKKQIVAIKIFSDNKEGKKSWRNESTVYSILQNGPHPNILKYFGAERRMKDSITELWLVVEYYPLGSLWNYLKKSTVTWSDLLQICQNIAAGLAHLHS--FSKPINSPIAHRDIKSKNILLKENYTACIADFGLAICHQNTDNSF----NNRVGTLSYMAPEILEGSINFDIYSFL-KIDIFSMSLVFWEVLSRFQFSDLHIKDFQNPFQEIVGENPSFEQLRQCVTIKKLRPAFNENWINLPDVIKFWKTITECWDEDPDARLSA 1568
            + + +G++G+VW G     + H + I A+KIF    E  +SW+ E+ +YS +    H NIL + G++   ++S T+LWL+  YYPLGSL+++L ++ ++ +D++ IC +IA GL HLH+  F K     +AHRD+KSKNIL+  N +  IADFGLA+ H +         N +VGT  YMAPE+L+ SI+ + +  L + DI++  LV WEV  R   S    ++++ PF ++V  +PSFE +R+ V I   RP+    W +   +    K + ECW ++PD RL A
Sbjct:  280 ECIGRGKYGEVWRG-----HWHGESI-AVKIFFSRDE--ESWKRETEIYSTILLR-HENILGFIGSDMTSRNSCTQLWLMTHYYPLGSLFDHLNRNALSHNDMVWICLSIANGLVHLHTEIFGKQGKPAMAHRDLKSKNILVTSNGSCVIADFGLAVTHSHVTGQLDLGNNPKVGTKRYMAPEVLDESIDLECFEALRRTDIYAFGLVLWEVCRR-TISCGIAEEYKVPFYDVVPMDPSFEDMRKVVCIDNYRPSIPNRWSSDSLMTGMSKLMKECWHQNPDVRLPA 556

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BLAST of Receptor protein serine/threonine kinase vs. Ensembl Zebrafish
Match: acvr2bb (activin A receptor type 2Bb [Source:ZFIN;Acc:ZDB-GENE-170621-5])

HSP 1 Score: 240.35 bits (612), Expect = 3.770e-72
Identity = 130/300 (43.33%), Postives = 187/300 (62.33%), Query Frame = 3

Query:  729 QLLAQGRFGQVWSGIIETRNEHKKQIVAIKIFSDNKEGKKSWRNESTVYSILQNGPHPNILKYFGAERRMKDSITELWLVVEYYPLGSLWNYLKKSTVTWSDLLQICQNIAAGLAHLHS----FSKPINSPIAHRDIKSKNILLKENYTACIADFGLAICHQ--NTDNSFNNRVGTLSYMAPEILEGSINFDIYSFLKIDIFSMSLVFWEVLSRFQFSDLHIKDFQNPFQEIVGENPSFEQLRQCVTIKKLRPAFNENWINLPDVIKFWKTITECWDEDPDARLSAECVLERMNDLCNIN 1610
            +L A+GRFG VW   + +      + VA+KIF    + K+SW+NE  +Y + +   H NIL Y  AE+R  +   ELWLV E++  GSL +YLK + V+W  L  I  +++ GLA+LH      ++     IAHRD KSKN+LLK + TA IADFGLA+  +        + +VGT  YMAPE+LEG+INF   SFL+ID++++ LV WE++SR   SD  + ++Q PF+E VG++PS E L+  V  KK+RP F + W+    + +  +TI ECWD D +ARLSA CV ER++ +   N
Sbjct:  191 ELKARGRFGCVWKAQLLS------EYVAVKIFP--IQDKQSWQNERDIY-LTEGFKHENILHYISAEKRGTNLQMELWLVTEFHERGSLTDYLKGNVVSWPQLCHISASMSRGLAYLHEDLPYRAEGPKPAIAHRDFKSKNVLLKMDLTAVIADFGLAVRFEPGKPPGDTHGQVGTRRYMAPEVLEGAINFQRDSFLRIDMYALGLVLWELVSRCTASDGPVGEYQLPFEEEVGQHPSLEDLQDAVVHKKMRPVFKDCWVKHQGLSQLCETIEECWDHDAEARLSAGCVEERISTISKSN 481

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BLAST of Receptor protein serine/threonine kinase vs. Ensembl Zebrafish
Match: acvr2aa (activin A receptor type 2Aa [Source:ZFIN;Acc:ZDB-GENE-980526-227])

HSP 1 Score: 238.424 bits (607), Expect = 1.144e-71
Identity = 132/302 (43.71%), Postives = 190/302 (62.91%), Query Frame = 3

Query:  729 QLLAQGRFGQVWSGIIETRNEHKKQIVAIKIFSDNKEGKKSWRNESTVYSILQNGPHPNILKYFGAERRMKDSITELWLVVEYYPLGSLWNYLKKSTVTWSDLLQICQNIAAGLAHLHS---FSKPINSP-IAHRDIKSKNILLKENYTACIADFGLAICHQ--NTDNSFNNRVGTLSYMAPEILEGSINFDIYSFLKIDIFSMSLVFWEVLSRFQFSDLHIKDFQNPFQEIVGENPSFEQLRQCVTIKKLRPAFNENWINLPDVIKFWKTITECWDEDPDARLSAECVLERMNDLCNINSI 1616
            ++ A+GRFG VW    +  N++    VA+KIF    + K SW+NE  +Y+I     H NIL++ GAE+R  +   ELWL+  Y+   SL +YLK + VTW++L  I Q +A GLA+LHS     +  + P IAHRD KSKN+LLK N TACIADFGLA+  +   +    + +VGT  YMAPE+LEG+INF   +FL+ID++++ LV WE+ +R   SD  + ++  PF+E VG++P+ E +++ V  KKLRP   E W   P +    +TI ECWD + +ARLSA CV ER+  +    S+
Sbjct:  178 EIKARGRFGCVWKA--QLLNDY----VAVKIFP--IQDKLSWQNEYDIYNI-PGMRHENILQFIGAEKRGSNLDIELWLITAYHEKSSLTDYLKANVVTWNELCHIAQTMARGLAYLHSDFPGHRDGHKPAIAHRDFKSKNVLLKTNLTACIADFGLALKFEAGKSAGDTHGQVGTRRYMAPEVLEGAINFQRDAFLRIDMYAVGLVLWELAARCTASDGPVDEYMLPFEEEVGQHPTLEDMQEVVVHKKLRPTLRECWQKHPGLAMLCETIEECWDHEAEARLSAGCVEERVVQMQRQTSV 470

[Close]

BLAST of Receptor protein serine/threonine kinase vs. Ensembl Zebrafish
Match: acvr2aa (activin A receptor type 2Aa [Source:ZFIN;Acc:ZDB-GENE-980526-227])

HSP 1 Score: 238.81 bits (608), Expect = 1.460e-71
Identity = 132/302 (43.71%), Postives = 190/302 (62.91%), Query Frame = 3

Query:  729 QLLAQGRFGQVWSGIIETRNEHKKQIVAIKIFSDNKEGKKSWRNESTVYSILQNGPHPNILKYFGAERRMKDSITELWLVVEYYPLGSLWNYLKKSTVTWSDLLQICQNIAAGLAHLHS---FSKPINSP-IAHRDIKSKNILLKENYTACIADFGLAICHQ--NTDNSFNNRVGTLSYMAPEILEGSINFDIYSFLKIDIFSMSLVFWEVLSRFQFSDLHIKDFQNPFQEIVGENPSFEQLRQCVTIKKLRPAFNENWINLPDVIKFWKTITECWDEDPDARLSAECVLERMNDLCNINSI 1616
            ++ A+GRFG VW    +  N++    VA+KIF    + K SW+NE  +Y+I     H NIL++ GAE+R  +   ELWL+  Y+   SL +YLK + VTW++L  I Q +A GLA+LHS     +  + P IAHRD KSKN+LLK N TACIADFGLA+  +   +    + +VGT  YMAPE+LEG+INF   +FL+ID++++ LV WE+ +R   SD  + ++  PF+E VG++P+ E +++ V  KKLRP   E W   P +    +TI ECWD + +ARLSA CV ER+  +    S+
Sbjct:  197 EIKARGRFGCVWKA--QLLNDY----VAVKIFP--IQDKLSWQNEYDIYNI-PGMRHENILQFIGAEKRGSNLDIELWLITAYHEKSSLTDYLKANVVTWNELCHIAQTMARGLAYLHSDFPGHRDGHKPAIAHRDFKSKNVLLKTNLTACIADFGLALKFEAGKSAGDTHGQVGTRRYMAPEVLEGAINFQRDAFLRIDMYAVGLVLWELAARCTASDGPVDEYMLPFEEEVGQHPTLEDMQEVVVHKKLRPTLRECWQKHPGLAMLCETIEECWDHEAEARLSAGCVEERVVQMQRQTSV 489

[Close]

BLAST of Receptor protein serine/threonine kinase vs. Ensembl Zebrafish
Match: acvr2aa (activin A receptor type 2Aa [Source:ZFIN;Acc:ZDB-GENE-980526-227])

HSP 1 Score: 239.195 bits (609), Expect = 1.988e-71
Identity = 132/302 (43.71%), Postives = 190/302 (62.91%), Query Frame = 3

Query:  729 QLLAQGRFGQVWSGIIETRNEHKKQIVAIKIFSDNKEGKKSWRNESTVYSILQNGPHPNILKYFGAERRMKDSITELWLVVEYYPLGSLWNYLKKSTVTWSDLLQICQNIAAGLAHLHS---FSKPINSP-IAHRDIKSKNILLKENYTACIADFGLAICHQ--NTDNSFNNRVGTLSYMAPEILEGSINFDIYSFLKIDIFSMSLVFWEVLSRFQFSDLHIKDFQNPFQEIVGENPSFEQLRQCVTIKKLRPAFNENWINLPDVIKFWKTITECWDEDPDARLSAECVLERMNDLCNINSI 1616
            ++ A+GRFG VW    +  N++    VA+KIF    + K SW+NE  +Y+I     H NIL++ GAE+R  +   ELWL+  Y+   SL +YLK + VTW++L  I Q +A GLA+LHS     +  + P IAHRD KSKN+LLK N TACIADFGLA+  +   +    + +VGT  YMAPE+LEG+INF   +FL+ID++++ LV WE+ +R   SD  + ++  PF+E VG++P+ E +++ V  KKLRP   E W   P +    +TI ECWD + +ARLSA CV ER+  +    S+
Sbjct:  221 EIKARGRFGCVWKA--QLLNDY----VAVKIFP--IQDKLSWQNEYDIYNI-PGMRHENILQFIGAEKRGSNLDIELWLITAYHEKSSLTDYLKANVVTWNELCHIAQTMARGLAYLHSDFPGHRDGHKPAIAHRDFKSKNVLLKTNLTACIADFGLALKFEAGKSAGDTHGQVGTRRYMAPEVLEGAINFQRDAFLRIDMYAVGLVLWELAARCTASDGPVDEYMLPFEEEVGQHPTLEDMQEVVVHKKLRPTLRECWQKHPGLAMLCETIEECWDHEAEARLSAGCVEERVVQMQRQTSV 513

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BLAST of Receptor protein serine/threonine kinase vs. Ensembl Zebrafish
Match: acvr2ab (activin A receptor type 2Ab [Source:ZFIN;Acc:ZDB-GENE-120215-23])

HSP 1 Score: 226.483 bits (576), Expect = 8.909e-68
Identity = 124/302 (41.06%), Postives = 181/302 (59.93%), Query Frame = 3

Query:  729 QLLAQGRFGQVWSGIIETRNEHKKQIVAIKIFSDNKEGKKSWRNESTVYSILQNGPHPNILKYFGAERRMKDSITELWLVVEYYPLGSLWNYLKKSTVTWSDLLQICQNIAAGLAHLHS----FSKPINSPIAHRDIKSKNILLKENYTACIADFGLAICHQ--NTDNSFNNRVGTLSYMAPEILEGSINFDIYSFLKIDIFSMSLVFWEVLSRFQFSDLHIKDFQNPFQEIVGENPSFEQLRQCVTIKKLRPAFNENWINLPDVIKFWKTITECWDEDPDARLSAECVLERMNDLCNINSI 1616
            +L A+GRFG VW   + +      + VA+KIF    + K+SW+NE  +Y+      H N+L + GAE+R      ELWL+  Y+  GSL ++LK + ++W++L  I Q    GLA+LH             IAHRDIKSKN+LLK + TACIADFGLA+  +   +    + +VGT  YMAPE+LEG+I+F   +FL+ID+++  LV WE+ +R   +D  + +F  PF+E  G +PS E ++  V  KKLRP F E+W+    +    +T+ ECWD + +ARLSA CV ER+  +    SI
Sbjct:  122 ELKARGRFGCVWKAQLLS------EAVAVKIFP--VQNKQSWQNEYEIYNA-SGMKHENLLHFIGAEKRGNGVDIELWLITTYHEKGSLTDFLKANVLSWNELCLIAQTFVRGLAYLHEDIPNLKDGHKPAIAHRDIKSKNVLLKSDLTACIADFGLALKFEAGKSTGDTHGQVGTRRYMAPEVLEGAISFQRDAFLRIDMYAAGLVLWELATRCTAADGPVDEFCLPFEEEAGLHPSLEDMQDVVVHKKLRPIFREHWLKHTGLSLLCETMEECWDHEAEARLSAGCVEERIISMQRSTSI 414

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BLAST of Receptor protein serine/threonine kinase vs. Ensembl Xenopus
Match: acvr2a (activin A receptor type 2A [Source:NCBI gene;Acc:100216172])

HSP 1 Score: 237.269 bits (604), Expect = 4.613e-71
Identity = 132/306 (43.14%), Postives = 186/306 (60.78%), Query Frame = 3

Query:  729 QLLAQGRFGQVWSGIIETRNEHKKQIVAIKIFSDNKEGKKSWRNESTVYSILQNGPHPNILKYFGAERRMKDSITELWLVVEYYPLGSLWNYLKKSTVTWSDLLQICQNIAAGLAHLH----SFSKPINSPIAHRDIKSKNILLKENYTACIADFGLAICHQ--NTDNSFNNRVGTLSYMAPEILEGSINFDIYSFLKIDIFSMSLVFWEVLSRFQFSDLHIKDFQNPFQEIVGENPSFEQLRQCVTIKKLRPAFNENWINLPDVIKFWKTITECWDEDPDARLSAECVLER---MNDLCNINSIE 1619
            ++ A+GRFG VW   +        + VA+KIF    + K SW+NE  +Y+ L    H NIL++ GAE+R  +  T+LWL+  ++  GSL +YLK + V+W++L  I + +A GLA+LH             +AHRDIKSKNILLK + TACIADFGLA+  +   +    + +VGT  YMAPE+LEG+INF   +FL+ID+++  LV WE+ SR   SD  + ++  PF+E VG++PS E +++ V  KK RP   E W     +    +TI ECWD D +ARLSA CV ER   M  L NI + E
Sbjct:  178 EVKARGRFGCVWKAQL------LNETVAVKIFP--IQDKLSWQNEYEIYN-LPGMKHENILQFIGAEKRGTNLDTDLWLITAFHEKGSLTDYLKANVVSWNELCHIAETMARGLAYLHEDIPGLKDGHKPAVAHRDIKSKNILLKNSLTACIADFGLALKFEAGKSAGDTHGQVGTRRYMAPEVLEGAINFQRDAFLRIDMYAFGLVLWELASRCTASDGPVDEYMLPFEEEVGQHPSLEDMQEVVVHKKKRPILRECWQKHAGMAMLCETIEECWDHDAEARLSAGCVEERIIQMQKLTNIITTE 474

[Close]

BLAST of Receptor protein serine/threonine kinase vs. Ensembl Xenopus
Match: acvr2a (activin A receptor type 2A [Source:NCBI gene;Acc:100216172])

HSP 1 Score: 237.269 bits (604), Expect = 7.448e-71
Identity = 132/306 (43.14%), Postives = 187/306 (61.11%), Query Frame = 3

Query:  729 QLLAQGRFGQVWSGIIETRNEHKKQIVAIKIFSDNKEGKKSWRNESTVYSILQNGPHPNILKYFGAERRMKDSITELWLVVEYYPLGSLWNYLKKSTVTWSDLLQICQNIAAGLAHLH----SFSKPINSPIAHRDIKSKNILLKENYTACIADFGLAICHQ--NTDNSFNNRVGTLSYMAPEILEGSINFDIYSFLKIDIFSMSLVFWEVLSRFQFSDLHIKDFQNPFQEIVGENPSFEQLRQCVTIKKLRPAFNENWINLPDVIKFWKTITECWDEDPDARLSAECVLER---MNDLCNINSIE 1619
            ++ A+GRFG VW      + +   + VA+KIF    + K SW+NE  +Y+ L    H NIL++ GAE+R  +  T+LWL+  ++  GSL +YLK + V+W++L  I + +A GLA+LH             +AHRDIKSKNILLK + TACIADFGLA+  +   +    + +VGT  YMAPE+LEG+INF   +FL+ID+++  LV WE+ SR   SD  + ++  PF+E VG++PS E +++ V  KK RP   E W     +    +TI ECWD D +ARLSA CV ER   M  L NI + E
Sbjct:  192 EVKARGRFGCVW------KAQLLNETVAVKIFP--IQDKLSWQNEYEIYN-LPGMKHENILQFIGAEKRGTNLDTDLWLITAFHEKGSLTDYLKANVVSWNELCHIAETMARGLAYLHEDIPGLKDGHKPAVAHRDIKSKNILLKNSLTACIADFGLALKFEAGKSAGDTHGQVGTRRYMAPEVLEGAINFQRDAFLRIDMYAFGLVLWELASRCTASDGPVDEYMLPFEEEVGQHPSLEDMQEVVVHKKKRPILRECWQKHAGMAMLCETIEECWDHDAEARLSAGCVEERIIQMQKLTNIITTE 488

[Close]

BLAST of Receptor protein serine/threonine kinase vs. Ensembl Xenopus
Match: acvr2a (activin A receptor type 2A [Source:NCBI gene;Acc:100216172])

HSP 1 Score: 237.269 bits (604), Expect = 7.866e-71
Identity = 132/306 (43.14%), Postives = 187/306 (61.11%), Query Frame = 3

Query:  729 QLLAQGRFGQVWSGIIETRNEHKKQIVAIKIFSDNKEGKKSWRNESTVYSILQNGPHPNILKYFGAERRMKDSITELWLVVEYYPLGSLWNYLKKSTVTWSDLLQICQNIAAGLAHLH----SFSKPINSPIAHRDIKSKNILLKENYTACIADFGLAICHQ--NTDNSFNNRVGTLSYMAPEILEGSINFDIYSFLKIDIFSMSLVFWEVLSRFQFSDLHIKDFQNPFQEIVGENPSFEQLRQCVTIKKLRPAFNENWINLPDVIKFWKTITECWDEDPDARLSAECVLER---MNDLCNINSIE 1619
            ++ A+GRFG VW      + +   + VA+KIF    + K SW+NE  +Y+ L    H NIL++ GAE+R  +  T+LWL+  ++  GSL +YLK + V+W++L  I + +A GLA+LH             +AHRDIKSKNILLK + TACIADFGLA+  +   +    + +VGT  YMAPE+LEG+INF   +FL+ID+++  LV WE+ SR   SD  + ++  PF+E VG++PS E +++ V  KK RP   E W     +    +TI ECWD D +ARLSA CV ER   M  L NI + E
Sbjct:  196 EVKARGRFGCVW------KAQLLNETVAVKIFP--IQDKLSWQNEYEIYN-LPGMKHENILQFIGAEKRGTNLDTDLWLITAFHEKGSLTDYLKANVVSWNELCHIAETMARGLAYLHEDIPGLKDGHKPAVAHRDIKSKNILLKNSLTACIADFGLALKFEAGKSAGDTHGQVGTRRYMAPEVLEGAINFQRDAFLRIDMYAFGLVLWELASRCTASDGPVDEYMLPFEEEVGQHPSLEDMQEVVVHKKKRPILRECWQKHAGMAMLCETIEECWDHDAEARLSAGCVEERIIQMQKLTNIITTE 492

[Close]

BLAST of Receptor protein serine/threonine kinase vs. Ensembl Xenopus
Match: acvr2a (activin A receptor type 2A [Source:NCBI gene;Acc:100216172])

HSP 1 Score: 236.884 bits (603), Expect = 8.365e-71
Identity = 132/306 (43.14%), Postives = 187/306 (61.11%), Query Frame = 3

Query:  729 QLLAQGRFGQVWSGIIETRNEHKKQIVAIKIFSDNKEGKKSWRNESTVYSILQNGPHPNILKYFGAERRMKDSITELWLVVEYYPLGSLWNYLKKSTVTWSDLLQICQNIAAGLAHLH----SFSKPINSPIAHRDIKSKNILLKENYTACIADFGLAICHQ--NTDNSFNNRVGTLSYMAPEILEGSINFDIYSFLKIDIFSMSLVFWEVLSRFQFSDLHIKDFQNPFQEIVGENPSFEQLRQCVTIKKLRPAFNENWINLPDVIKFWKTITECWDEDPDARLSAECVLER---MNDLCNINSIE 1619
            ++ A+GRFG VW      + +   + VA+KIF    + K SW+NE  +Y+ L    H NIL++ GAE+R  +  T+LWL+  ++  GSL +YLK + V+W++L  I + +A GLA+LH             +AHRDIKSKNILLK + TACIADFGLA+  +   +    + +VGT  YMAPE+LEG+INF   +FL+ID+++  LV WE+ SR   SD  + ++  PF+E VG++PS E +++ V  KK RP   E W     +    +TI ECWD D +ARLSA CV ER   M  L NI + E
Sbjct:  189 EVKARGRFGCVW------KAQLLNETVAVKIFP--IQDKLSWQNEYEIYN-LPGMKHENILQFIGAEKRGTNLDTDLWLITAFHEKGSLTDYLKANVVSWNELCHIAETMARGLAYLHEDIPGLKDGHKPAVAHRDIKSKNILLKNSLTACIADFGLALKFEAGKSAGDTHGQVGTRRYMAPEVLEGAINFQRDAFLRIDMYAFGLVLWELASRCTASDGPVDEYMLPFEEEVGQHPSLEDMQEVVVHKKKRPILRECWQKHAGMAMLCETIEECWDHDAEARLSAGCVEERIIQMQKLTNIITTE 485

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BLAST of Receptor protein serine/threonine kinase vs. Ensembl Xenopus
Match: acvr2a (activin A receptor type 2A [Source:NCBI gene;Acc:100216172])

HSP 1 Score: 237.269 bits (604), Expect = 8.413e-71
Identity = 132/306 (43.14%), Postives = 187/306 (61.11%), Query Frame = 3

Query:  729 QLLAQGRFGQVWSGIIETRNEHKKQIVAIKIFSDNKEGKKSWRNESTVYSILQNGPHPNILKYFGAERRMKDSITELWLVVEYYPLGSLWNYLKKSTVTWSDLLQICQNIAAGLAHLH----SFSKPINSPIAHRDIKSKNILLKENYTACIADFGLAICHQ--NTDNSFNNRVGTLSYMAPEILEGSINFDIYSFLKIDIFSMSLVFWEVLSRFQFSDLHIKDFQNPFQEIVGENPSFEQLRQCVTIKKLRPAFNENWINLPDVIKFWKTITECWDEDPDARLSAECVLER---MNDLCNINSIE 1619
            ++ A+GRFG VW      + +   + VA+KIF    + K SW+NE  +Y+ L    H NIL++ GAE+R  +  T+LWL+  ++  GSL +YLK + V+W++L  I + +A GLA+LH             +AHRDIKSKNILLK + TACIADFGLA+  +   +    + +VGT  YMAPE+LEG+INF   +FL+ID+++  LV WE+ SR   SD  + ++  PF+E VG++PS E +++ V  KK RP   E W     +    +TI ECWD D +ARLSA CV ER   M  L NI + E
Sbjct:  194 EVKARGRFGCVW------KAQLLNETVAVKIFP--IQDKLSWQNEYEIYN-LPGMKHENILQFIGAEKRGTNLDTDLWLITAFHEKGSLTDYLKANVVSWNELCHIAETMARGLAYLHEDIPGLKDGHKPAVAHRDIKSKNILLKNSLTACIADFGLALKFEAGKSAGDTHGQVGTRRYMAPEVLEGAINFQRDAFLRIDMYAFGLVLWELASRCTASDGPVDEYMLPFEEEVGQHPSLEDMQEVVVHKKKRPILRECWQKHAGMAMLCETIEECWDHDAEARLSAGCVEERIIQMQKLTNIITTE 490

[Close]

BLAST of Receptor protein serine/threonine kinase vs. Ensembl Mouse
Match: Acvr2a (activin receptor IIA [Source:MGI Symbol;Acc:MGI:102806])

HSP 1 Score: 238.424 bits (607), Expect = 1.938e-71
Identity = 128/302 (42.38%), Postives = 187/302 (61.92%), Query Frame = 3

Query:  729 QLLAQGRFGQVWSGIIETRNEHKKQIVAIKIFSDNKEGKKSWRNESTVYSILQNGPHPNILKYFGAERRMKDSITELWLVVEYYPLGSLWNYLKKSTVTWSDLLQICQNIAAGLAHLH----SFSKPINSPIAHRDIKSKNILLKENYTACIADFGLAICHQ--NTDNSFNNRVGTLSYMAPEILEGSINFDIYSFLKIDIFSMSLVFWEVLSRFQFSDLHIKDFQNPFQEIVGENPSFEQLRQCVTIKKLRPAFNENWINLPDVIKFWKTITECWDEDPDARLSAECVLERMNDLCNINSI 1616
            ++ A+GRFG VW    +  NE+    VA+KIF    + K+SW+NE  VYS L    H NIL++ GAE+R      +LWL+  ++  GSL ++LK + V+W++L  I + +A GLA+LH             I+HRDIKSKN+LLK N TACIADFGLA+  +   +    + +VGT  YMAPE+LEG+INF   +FL+ID+++M LV WE+ SR   +D  + ++  PF+E +G++PS E +++ V  KK RP   + W     +    +TI ECWD D +ARLSA CV ER+  +  + +I
Sbjct:  196 EVKARGRFGCVWKA--QLLNEY----VAVKIFP--IQDKQSWQNEYEVYS-LPGMKHENILQFIGAEKRGTSVDVDLWLITAFHEKGSLSDFLKANVVSWNELCHIAETMARGLAYLHEDIPGLKDGHKPAISHRDIKSKNVLLKNNLTACIADFGLALKFEAGKSAGDTHGQVGTRRYMAPEVLEGAINFQRDAFLRIDMYAMGLVLWELASRCTAADGPVDEYMLPFEEEIGQHPSLEDMQEVVVHKKKRPVLRDYWQKHAGMAMLCETIEECWDHDAEARLSAGCVGERITQMQRLTNI 488

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BLAST of Receptor protein serine/threonine kinase vs. Ensembl Mouse
Match: Acvr2b (activin receptor IIB [Source:MGI Symbol;Acc:MGI:87912])

HSP 1 Score: 232.646 bits (592), Expect = 4.227e-69
Identity = 144/452 (31.86%), Postives = 230/452 (50.88%), Query Frame = 3

Query:  273 WPNTSDCPDEAGPCYLLGHNTKQPACCCKGNLCNDISVKY-SIKFPKVYTTINPQSLVMIPNTGQVNI----FWIYXXXXXXXXXXXXXXXXXXKRFAIHSKTSINSNRKIFDVENINDNVRTPIAKLCENGSRYEENTVLINQISTENLYSLCDKNQLLAQGRFGQVWSGIIETRNEHKKQIVAIKIFSDNKEGKKSWRNESTVYSILQNGPHPNILKYFGAERRMKDSITELWLVVEYYPLGSLWNYLKKSTVTWSDLLQICQNIAAGLAHLHS-----FSKPINSPIAHRDIKSKNILLKENYTACIADFGLAICHQ--NTDNSFNNRVGTLSYMAPEILEGSINFDIYSFLKIDIFSMSLVFWEVLSRFQFSDLHIKDFQNPFQEIVGENPSFEQLRQCVTIKKLRPAFNENWINLPDVIKFWKTITECWDEDPDARLSAECVLERMN 1592
            W +  +C D    C     N +   CCC+GN CN+          P+  T +   +  ++P  G   I    FW+Y                   R   +    I+  R+        D        L          + L+     + L       ++ A+GRFG VW      + +     VA+KIF    + K+SW++E  ++S      H N+L++  AE+R  +   ELWL+  ++  GSL +YLK + +TW++L  + + ++ GL++LH        +     IAHRD KSKN+LLK + TA +ADFGLA+  +        + +VGT  YMAPE+LEG+INF   +FL+ID+++M LV WE++SR + +D  + ++  PF+E +G++PS E+L++ V  KK+RP   ++W+  P + +   TI ECWD D +ARLSA CV ER++
Sbjct:   78 WLDDFNCYDRQ-ECVATEENPQVYFCCCEGNFCNERFTHLPEPGGPEAPTLLTVLAYSLLPIGGLSLIVLLAFWMYR-----------------HRKPPYGHVDIHEVRQCQRWAGRRDGCADSFKPLPFQDPGPPPPSPLVGLKPLQLL-------EIKARGRFGCVW------KAQLMNDFVAVKIFP--LQDKQSWQSEREIFST-PGMKHENLLQFIAAEKRGSNLEVELWLITAFHDKGSLTDYLKGNIITWNELCHVAETMSRGLSYLHEDVPWCRGEGHKPSIAHRDFKSKNVLLKSDLTAVLADFGLAVRFEPGKPPGDTHGQVGTRRYMAPEVLEGAINFQRDAFLRIDMYAMGLVLWELVSRCKAADGPVDEYMLPFEEEIGQHPSLEELQEVVVHKKMRPTIKDHWLKHPGLAQLCVTIEECWDHDAEARLSAGCVEERVS 495

[Close]

BLAST of Receptor protein serine/threonine kinase vs. Ensembl Mouse
Match: Acvr2b (activin receptor IIB [Source:MGI Symbol;Acc:MGI:87912])

HSP 1 Score: 230.335 bits (586), Expect = 2.307e-68
Identity = 117/295 (39.66%), Postives = 186/295 (63.05%), Query Frame = 3

Query:  729 QLLAQGRFGQVWSGIIETRNEHKKQIVAIKIFSDNKEGKKSWRNESTVYSILQNGPHPNILKYFGAERRMKDSITELWLVVEYYPLGSLWNYLKKSTVTWSDLLQICQNIAAGLAHLHS-----FSKPINSPIAHRDIKSKNILLKENYTACIADFGLAICHQ--NTDNSFNNRVGTLSYMAPEILEGSINFDIYSFLKIDIFSMSLVFWEVLSRFQFSDLHIKDFQNPFQEIVGENPSFEQLRQCVTIKKLRPAFNENWINLPDVIKFWKTITECWDEDPDARLSAECVLERMN 1592
            ++ A+GRFG VW      + +     VA+KIF    + K+SW++E  ++S      H N+L++  AE+R  +   ELWL+  ++  GSL +YLK + +TW++L  + + ++ GL++LH        +     IAHRD KSKN+LLK + TA +ADFGLA+  +        + +VGT  YMAPE+LEG+INF   +FL+ID+++M LV WE++SR + +D  + ++  PF+E +G++PS E+L++ V  KK+RP   ++W+  P + +   TI ECWD D +ARLSA CV ER++
Sbjct:  194 EIKARGRFGCVW------KAQLMNDFVAVKIFP--LQDKQSWQSEREIFST-PGMKHENLLQFIAAEKRGSNLEVELWLITAFHDKGSLTDYLKGNIITWNELCHVAETMSRGLSYLHEDVPWCRGEGHKPSIAHRDFKSKNVLLKSDLTAVLADFGLAVRFEPGKPPGDTHGQVGTRRYMAPEVLEGAINFQRDAFLRIDMYAMGLVLWELVSRCKAADGPVDEYMLPFEEEIGQHPSLEELQEVVVHKKMRPTIKDHWLKHPGLAQLCVTIEECWDHDAEARLSAGCVEERVS 479

[Close]

BLAST of Receptor protein serine/threonine kinase vs. Ensembl Mouse
Match: Acvr2b (activin receptor IIB [Source:MGI Symbol;Acc:MGI:87912])

HSP 1 Score: 230.72 bits (587), Expect = 3.331e-68
Identity = 146/461 (31.67%), Postives = 231/461 (50.11%), Query Frame = 3

Query:  273 WPNTSDCPDEAGPCYLLGHNTKQPACCCKGNLCND----------ISVKYSIKFPKVYTTINPQSLVMIPNTGQVNI----FWIYXXXXXXXXXXXXXXXXXXKRFAIHSKTSINSNRKIFDVENINDNVRTPIAKLCENGSRYEENTVLINQISTENLYSLCDKNQLLAQGRFGQVWSGIIETRNEHKKQIVAIKIFSDNKEGKKSWRNESTVYSILQNGPHPNILKYFGAERRMKDSITELWLVVEYYPLGSLWNYLKKSTVTWSDLLQICQNIAAGLAHLHS-----FSKPINSPIAHRDIKSKNILLKENYTACIADFGLAICHQ--NTDNSFNNRVGTLSYMAPEILEGSINFDIYSFLKIDIFSMSLVFWEVLSRFQFSDLHIKDFQNPFQEIVGENPSFEQLRQCVTIKKLRPAFNENWINLPDVIKFWKTITECWDEDPDARLSAECVLERMN 1592
            W +  +C D    C     N +   CCC+GN CN+            V Y    P   T +   +  ++P  G   I    FW+Y                   R   +    I+  R+        D        L          + L+     + L       ++ A+GRFG VW      + +     VA+KIF    + K+SW++E  ++S      H N+L++  AE+R  +   ELWL+  ++  GSL +YLK + +TW++L  + + ++ GL++LH        +     IAHRD KSKN+LLK + TA +ADFGLA+  +        + +VGT  YMAPE+LEG+INF   +FL+ID+++M LV WE++SR + +D  + ++  PF+E +G++PS E+L++ V  KK+RP   ++W+  P + +   TI ECWD D +ARLSA CV ER++
Sbjct:   78 WLDDFNCYDRQ-ECVATEENPQVYFCCCEGNFCNERFTHLPEPGGPEVTYEPP-PTAPTLLTVLAYSLLPIGGLSLIVLLAFWMYR-----------------HRKPPYGHVDIHEVRQCQRWAGRRDGCADSFKPLPFQDPGPPPPSPLVGLKPLQLL-------EIKARGRFGCVW------KAQLMNDFVAVKIFP--LQDKQSWQSEREIFST-PGMKHENLLQFIAAEKRGSNLEVELWLITAFHDKGSLTDYLKGNIITWNELCHVAETMSRGLSYLHEDVPWCRGEGHKPSIAHRDFKSKNVLLKSDLTAVLADFGLAVRFEPGKPPGDTHGQVGTRRYMAPEVLEGAINFQRDAFLRIDMYAMGLVLWELVSRCKAADGPVDEYMLPFEEEIGQHPSLEELQEVVVHKKMRPTIKDHWLKHPGLAQLCVTIEECWDHDAEARLSAGCVEERVS 503

[Close]

BLAST of Receptor protein serine/threonine kinase vs. Ensembl Mouse
Match: Tgfbr2 (transforming growth factor, beta receptor II [Source:MGI Symbol;Acc:MGI:98729])

HSP 1 Score: 216.083 bits (549), Expect = 1.577e-62
Identity = 138/429 (32.17%), Postives = 225/429 (52.45%), Query Frame = 3

Query:  348 CCCKGNLCNDISVKYSIKFPKVYTTINPQSLVMIPNTGQVNIFWIYXXXXXXXXXXXXXXXXXXKRFAIHSKTSINSNRKIFDVEN----INDNVRTPIAKLCENGSRYEENTVLINQISTENLYSLCDKNQLLAQGRFGQVWSGIIETRNEHKKQIVAIKIFSDNKEGKKSWRNESTVYSILQNGPHPNILKYFGAERRMKDSITELWLVVEYYPLGSLWNYLKKSTVTWSDLLQICQNIAAGLAHLHSFSKPINSP---IAHRDIKSKNILLKENYTACIADFGLAICHQNT----DNSFNNRVGTLSYMAPEILEGSINFD-IYSFLKIDIFSMSLVFWEVLSRFQFSDLHIKDFQNPFQEIVGENPSFEQLRQCVTIKKLRPAFNENWINLPDVIKFWKTITECWDEDPDARLSAECVLERMNDL 1598
            C C    CND      I F + YTT +P  L++I     V++     + +  I +         ++ +   ++S    RK+ D  +    I ++ R+ I+  C N   +  NT L+            + + L+ +GRF +V+   ++     + + VA+KIF    E   SW+ E  ++S + N  H NIL++  AE R  +   + WL+  ++  G+L  YL +  ++W DL ++  ++A G+AHLHS   P   P   I HRD+KS NIL+K + T C+ DFGL++    T    D + + +VGT  YMAPE+LE  +N + + SF + D++SM+LV WE+ SR       +KD++ PF   V E+P  E ++  V   + RP     W+N   +    +T+TECWD DP+ARL+A+CV ER ++L
Sbjct:  136 CACNMEECNDY-----IIFSEEYTTSSPDLLLVIIQVTGVSLLPPLGIAIAVIIIFYCYRVHRQQKLSPSWESS--KPRKLMDFSDNCAIILEDDRSDISSTCANNINH--NTELLP----------IELDTLVGKGRFAEVYKAKLKQNTSEQFETVAVKIFP--YEEYSSWKTEKDIFSDI-NLKHENILQFLTAEERKTELGKQYWLITAFHAKGNLQEYLTRHVISWEDLRKLGSSLARGIAHLHSDHTPCGRPKMPIVHRDLKSSNILVKNDLTCCLCDFGLSLRLDPTLSVDDLANSGQVGTARYMAPEVLESRMNLENVESFKQTDVYSMALVLWEMTSRCNAVG-EVKDYEPPFGSKVREHPCVESMKDSVLRDRGRPEIPSFWLNHQGIQIVCETLTECWDHDPEARLTAQCVAERFSEL 541

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BLAST of Receptor protein serine/threonine kinase vs. UniProt/SwissProt
Match: sp|Q90669|AVR2A_CHICK (Activin receptor type-2A OS=Gallus gallus OX=9031 GN=ACVR2A PE=2 SV=1)

HSP 1 Score: 240.736 bits (613), Expect = 2.026e-71
Identity = 134/306 (43.79%), Postives = 188/306 (61.44%), Query Frame = 3

Query:  729 QLLAQGRFGQVWSGIIETRNEHKKQIVAIKIFSDNKEGKKSWRNESTVYSILQNGPHPNILKYFGAERRMKDSITELWLVVEYYPLGSLWNYLKKSTVTWSDLLQICQNIAAGLAHLH----SFSKPINSPIAHRDIKSKNILLKENYTACIADFGLAICHQ--NTDNSFNNRVGTLSYMAPEILEGSINFDIYSFLKIDIFSMSLVFWEVLSRFQFSDLHIKDFQNPFQEIVGENPSFEQLRQCVTIKKLRPAFNENWINLPDVIKFWKTITECWDEDPDARLSAECVLER---MNDLCNINSIE 1619
            ++ A+GRFG VW    +  NE+    VA+KIF    + K+SW+NE  +YS L    H NIL++ GAE+R      +LWL+  ++  GSL ++LK + V+W++L  I Q +A GLA+LH             I+HRDIKSKN+LLK N TACIADFGLA+  +   +    + +VGT  YMAPE+LEG+INF   +FL+ID+++M LV WE+ SR   SD  + ++  PF+E +G++PS E +++ V  KK RP   E W     +    +TI ECWD D +ARLSA CV ER   M  L NI + E
Sbjct:  196 EIKARGRFGCVWKA--QLLNEY----VAVKIFP--IQDKQSWQNEYEIYS-LPGMKHDNILQFIGAEKRGTSIDVDLWLITAFHEKGSLTDFLKANVVSWNELCHIAQTMARGLAYLHEDIPGLKDGHKPAISHRDIKSKNVLLKNNLTACIADFGLALKFEAGKSAGDTHGQVGTRRYMAPEVLEGAINFQRDAFLRIDMYAMGLVLWELASRCTASDGPVDEYMLPFEEEIGQHPSLEDMQEVVVHKKKRPVLRECWQKHSGMAMLCETIEECWDHDAEARLSAGCVEERIIQMQKLTNIITTE 492

[Close]

BLAST of Receptor protein serine/threonine kinase vs. UniProt/SwissProt
Match: sp|P27039|AVR2A_XENLA (Activin receptor type-2A OS=Xenopus laevis OX=8355 GN=acvr2a PE=2 SV=1)

HSP 1 Score: 239.58 bits (610), Expect = 5.513e-71
Identity = 133/306 (43.46%), Postives = 186/306 (60.78%), Query Frame = 3

Query:  729 QLLAQGRFGQVWSGIIETRNEHKKQIVAIKIFSDNKEGKKSWRNESTVYSILQNGPHPNILKYFGAERRMKDSITELWLVVEYYPLGSLWNYLKKSTVTWSDLLQICQNIAAGLAHLH----SFSKPINSPIAHRDIKSKNILLKENYTACIADFGLAICHQ--NTDNSFNNRVGTLSYMAPEILEGSINFDIYSFLKIDIFSMSLVFWEVLSRFQFSDLHIKDFQNPFQEIVGENPSFEQLRQCVTIKKLRPAFNENWINLPDVIKFWKTITECWDEDPDARLSAECVLER---MNDLCNINSIE 1619
            ++ A+GRFG VW      + +   + VA+KIF    + K SW+NE  +YS L    H NIL + GAE+R  +  T+LWL+  ++  GSL +YLK + V+W++L  I + +A GL+HLH             +AHRDIKSKN+LLK N TACIADFGLA+  +   +    + +VGT  YMAPE+LEG+INF   +FL+ID+++  LV WE+ SR   SD  + ++  PF+E VG++PS E +++ V  KK RP   E W     +    +TI ECWD D +ARLSA CV ER   M  L NI + E
Sbjct:  197 EVKARGRFGCVW------KAQLLNETVAVKIFP--VQDKLSWQNEYEIYS-LPGMKHENILYFIGAEKRGTNLDTDLWLITAFHEKGSLTDYLKANVVSWNELCLIAETMARGLSHLHEDIPGLKDGHKPAVAHRDIKSKNVLLKNNLTACIADFGLALKFEAGKSAGDTHGQVGTRRYMAPEVLEGAINFQRDAFLRIDMYAFGLVLWELASRCTASDGPVDEYMLPFEEEVGQHPSLEDMQEVVVHKKKRPILRECWQKHAGMAMLCETIEECWDHDAEARLSAGCVEERIIQMQKLTNIITTE 493

[Close]

BLAST of Receptor protein serine/threonine kinase vs. UniProt/SwissProt
Match: sp|Q28043|AVR2A_BOVIN (Activin receptor type-2A OS=Bos taurus OX=9913 GN=ACVR2A PE=2 SV=1)

HSP 1 Score: 238.81 bits (608), Expect = 1.158e-70
Identity = 128/302 (42.38%), Postives = 187/302 (61.92%), Query Frame = 3

Query:  729 QLLAQGRFGQVWSGIIETRNEHKKQIVAIKIFSDNKEGKKSWRNESTVYSILQNGPHPNILKYFGAERRMKDSITELWLVVEYYPLGSLWNYLKKSTVTWSDLLQICQNIAAGLAHLH----SFSKPINSPIAHRDIKSKNILLKENYTACIADFGLAICHQ--NTDNSFNNRVGTLSYMAPEILEGSINFDIYSFLKIDIFSMSLVFWEVLSRFQFSDLHIKDFQNPFQEIVGENPSFEQLRQCVTIKKLRPAFNENWINLPDVIKFWKTITECWDEDPDARLSAECVLERMNDLCNINSI 1616
            ++ A+GRFG VW    +  NE+    VA+KIF    + K+SW+NE  VYS L    H NIL++ GAE+R      +LWL+  ++  GSL ++LK + V+W++L  I + +A GLA+LH             I+HRDIKSKN+LLK N TACIADFGLA+  +   +    + +VGT  YMAPE+LEG+INF   +FL+ID+++M LV WE+ SR   +D  + ++  PF+E +G++PS E +++ V  KK RP   + W     +    +TI ECWD D +ARLSA CV ER+  +  + +I
Sbjct:  196 EVKARGRFGCVWKA--QLLNEY----VAVKIFP--IQDKQSWQNEYEVYS-LPGMKHENILQFIGAEKRGTSVDVDLWLITAFHEKGSLSDFLKANVVSWNELCHIAETMARGLAYLHEDIPGLKDGHKPAISHRDIKSKNVLLKNNLTACIADFGLALKFEAGKSAGDTHGQVGTRRYMAPEVLEGAINFQRDAFLRIDMYAMGLVLWELASRCTAADGPVDEYMLPFEEEIGQHPSLEDMQEVVVHKKKRPVLRDYWQKHAGMAMLCETIEECWDHDAEARLSAGCVGERITQMQRLTNI 488

[Close]

BLAST of Receptor protein serine/threonine kinase vs. UniProt/SwissProt
Match: sp|P27037|AVR2A_HUMAN (Activin receptor type-2A OS=Homo sapiens OX=9606 GN=ACVR2A PE=1 SV=1)

HSP 1 Score: 238.81 bits (608), Expect = 1.208e-70
Identity = 128/302 (42.38%), Postives = 187/302 (61.92%), Query Frame = 3

Query:  729 QLLAQGRFGQVWSGIIETRNEHKKQIVAIKIFSDNKEGKKSWRNESTVYSILQNGPHPNILKYFGAERRMKDSITELWLVVEYYPLGSLWNYLKKSTVTWSDLLQICQNIAAGLAHLH----SFSKPINSPIAHRDIKSKNILLKENYTACIADFGLAICHQ--NTDNSFNNRVGTLSYMAPEILEGSINFDIYSFLKIDIFSMSLVFWEVLSRFQFSDLHIKDFQNPFQEIVGENPSFEQLRQCVTIKKLRPAFNENWINLPDVIKFWKTITECWDEDPDARLSAECVLERMNDLCNINSI 1616
            ++ A+GRFG VW    +  NE+    VA+KIF    + K+SW+NE  VYS L    H NIL++ GAE+R      +LWL+  ++  GSL ++LK + V+W++L  I + +A GLA+LH             I+HRDIKSKN+LLK N TACIADFGLA+  +   +    + +VGT  YMAPE+LEG+INF   +FL+ID+++M LV WE+ SR   +D  + ++  PF+E +G++PS E +++ V  KK RP   + W     +    +TI ECWD D +ARLSA CV ER+  +  + +I
Sbjct:  196 EVKARGRFGCVWKA--QLLNEY----VAVKIFP--IQDKQSWQNEYEVYS-LPGMKHENILQFIGAEKRGTSVDVDLWLITAFHEKGSLSDFLKANVVSWNELCHIAETMARGLAYLHEDIPGLKDGHKPAISHRDIKSKNVLLKNNLTACIADFGLALKFEAGKSAGDTHGQVGTRRYMAPEVLEGAINFQRDAFLRIDMYAMGLVLWELASRCTAADGPVDEYMLPFEEEIGQHPSLEDMQEVVVHKKKRPVLRDYWQKHAGMAMLCETIEECWDHDAEARLSAGCVGERITQMQRLTNI 488

[Close]

BLAST of Receptor protein serine/threonine kinase vs. UniProt/SwissProt
Match: sp|P27038|AVR2A_MOUSE (Activin receptor type-2A OS=Mus musculus OX=10090 GN=Acvr2a PE=1 SV=1)

HSP 1 Score: 238.424 bits (607), Expect = 1.356e-70
Identity = 128/302 (42.38%), Postives = 187/302 (61.92%), Query Frame = 3

Query:  729 QLLAQGRFGQVWSGIIETRNEHKKQIVAIKIFSDNKEGKKSWRNESTVYSILQNGPHPNILKYFGAERRMKDSITELWLVVEYYPLGSLWNYLKKSTVTWSDLLQICQNIAAGLAHLH----SFSKPINSPIAHRDIKSKNILLKENYTACIADFGLAICHQ--NTDNSFNNRVGTLSYMAPEILEGSINFDIYSFLKIDIFSMSLVFWEVLSRFQFSDLHIKDFQNPFQEIVGENPSFEQLRQCVTIKKLRPAFNENWINLPDVIKFWKTITECWDEDPDARLSAECVLERMNDLCNINSI 1616
            ++ A+GRFG VW    +  NE+    VA+KIF    + K+SW+NE  VYS L    H NIL++ GAE+R      +LWL+  ++  GSL ++LK + V+W++L  I + +A GLA+LH             I+HRDIKSKN+LLK N TACIADFGLA+  +   +    + +VGT  YMAPE+LEG+INF   +FL+ID+++M LV WE+ SR   +D  + ++  PF+E +G++PS E +++ V  KK RP   + W     +    +TI ECWD D +ARLSA CV ER+  +  + +I
Sbjct:  196 EVKARGRFGCVWKA--QLLNEY----VAVKIFP--IQDKQSWQNEYEVYS-LPGMKHENILQFIGAEKRGTSVDVDLWLITAFHEKGSLSDFLKANVVSWNELCHIAETMARGLAYLHEDIPGLKDGHKPAISHRDIKSKNVLLKNNLTACIADFGLALKFEAGKSAGDTHGQVGTRRYMAPEVLEGAINFQRDAFLRIDMYAMGLVLWELASRCTAADGPVDEYMLPFEEEIGQHPSLEDMQEVVVHKKKRPVLRDYWQKHAGMAMLCETIEECWDHDAEARLSAGCVGERITQMQRLTNI 488

[Close]

BLAST of Receptor protein serine/threonine kinase vs. TrEMBL
Match: A0A023F3N5 (Serine/threonine-protein kinase receptor (Fragment) OS=Triatoma infestans OX=30076 PE=2 SV=1)

HSP 1 Score: 255.373 bits (651), Expect = 7.349e-75
Identity = 125/294 (42.52%), Postives = 189/294 (64.29%), Query Frame = 3

Query:  729 QLLAQGRFGQVWSGIIETRNEHKKQIVAIKIFSDNKEGKKSWRNESTVYSILQNGPHPNILKYFGAERRMKDSITELWLVVEYYPLGSLWNYLKKSTVTWSDLLQICQNIAAGLAHLHSFSKPINS-----PIAHRDIKSKNILLKENYTACIADFGLAICHQNTD--NSFNNRVGTLSYMAPEILEGSINFDIYSFLKIDIFSMSLVFWEVLSRFQFSDLHIKDFQNPFQEIVGENPSFEQLRQCVTIKKLRPAFNENWINLPDVIKFWKTITECWDEDPDARLSAECVLERM 1589
            ++ A+GRFG VW      + ++K ++VA+KIF  +   K+SW++E  ++  L +  H +IL+Y G E+R     +E WL+  Y+ LGSL +YLK +T+TW+ L  + +++A GL HLH    P  +      IAHRD KSKN+LLK + TAC+ADFGLA+  Q        + +VGT  YMAPE+LEG+INF   +FL+ID+++  LV WE+ +R    D  + ++Q PF+E VG++P+ E +++CV  KK RP  N +W + P ++    T+ ECWD D +ARLSA CV+ER+
Sbjct:  181 EVKAKGRFGAVW------KAQYKTELVAVKIFPVHD--KQSWQSEQEIFK-LAHMRHDSILRYIGVEKRGDGLQSEYWLITAYHDLGSLCDYLKANTLTWAQLCHVAESMARGLMHLHEEMGPTKTEGYKPAIAHRDFKSKNVLLKSDLTACVADFGLALVFQPGKPCGDTHGQVGTRRYMAPEVLEGAINFSRDAFLRIDMYACGLVLWELATRCTAQDSAVGEYQLPFEEEVGQHPTLEDMQECVVHKKQRPLLNNSWKSHPGLLALCDTMEECWDHDAEARLSASCVMERI 465

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BLAST of Receptor protein serine/threonine kinase vs. TrEMBL
Match: R7TEH1 (Serine/threonine-protein kinase receptor OS=Capitella teleta OX=283909 GN=CAPTEDRAFT_94926 PE=3 SV=1)

HSP 1 Score: 252.677 bits (644), Expect = 2.986e-73
Identity = 127/297 (42.76%), Postives = 191/297 (64.31%), Query Frame = 3

Query:  729 QLLAQGRFGQVWSGIIETRNEHKKQIVAIKIFSDNKEGKKSWRNESTVYSILQNGPHPNILKYFGAERRMKDSITELWLVVEYYPLGSLWNYLKKSTVTWSDLLQICQNIAAGLAHLH-----SFSKPINSPIAHRDIKSKNILLKENYTACIADFGLAICHQN--TDNSFNNRVGTLSYMAPEILEGSINFDIYSFLKIDIFSMSLVFWEVLSRFQFSDLHIKDFQNPFQEIVGENPSFEQLRQCVTIKKLRPAFNENWINLPDVIKFWKTITECWDEDPDARLSAECVLERMNDL 1598
            ++ A+GRFG V+   +  R      ++A+K+F    + K+SW  E  +YS+ Q   H NIL Y GAE+R ++   +LWL+ +++  GSL++YLK + V+W  LL IC+++A GLA+LH     + ++     IAHRD KSKN+L+K + TACIADFGLA+  +   +    + +VGT  YMAPE+LEG+INF   SFL+ID+++  LV WE++SR   +D  +++++ P +E VG +PS E+++  V  KK RP F + W   P +     TI ECWD DP+ARLSA CV ER++ L
Sbjct:  197 EVKARGRFGCVYKAQMGER------VIAVKVFP--LQDKQSWATEKDIYSLPQLNCHANILHYIGAEKRGENLNMDLWLITQFHEQGSLYDYLKGNLVSWQQLLAICESMAKGLAYLHEDLPATRTQQAKPAIAHRDFKSKNVLIKSDLTACIADFGLALKFEGGVSVGETHGQVGTRRYMAPEVLEGAINFSRDSFLRIDMYACGLVLWELISRCSAADGPVEEYRLPLEEDVGTHPSLEEMQDAVVSKKSRPGFKDVWRKHPGLCTMCDTIEECWDHDPEARLSAGCVQERLSQL 485

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BLAST of Receptor protein serine/threonine kinase vs. TrEMBL
Match: A0A1S3IPV1 (Serine/threonine-protein kinase receptor OS=Lingula unguis OX=7574 GN=LOC106166288 PE=3 SV=1)

HSP 1 Score: 251.906 bits (642), Expect = 5.146e-73
Identity = 131/305 (42.95%), Postives = 198/305 (64.92%), Query Frame = 3

Query:  729 QLLAQGRFGQVWSGIIETRNEHKKQIVAIKIFSDNKEGKKSWRNESTVYSILQNGPHPNILKYFGAERRMKDSITELWLVVEYYPLGSLWNYLKKSTVTWSDLLQICQNIAAGLAHLH--------SFSKPINSPIAHRDIKSKNILLKENYTACIADFGLAICHQ--NTDNSFNNRVGTLSYMAPEILEGSINFDIYSFLKIDIFSMSLVFWEVLSRFQFSDLHIKDFQNPFQEIVGENPSFEQLRQCVTIKKLRPAFNENWINLPDVIKFWKTITECWDEDPDARLSAECVLERMNDLCNINS 1613
            +L A+GRFG VW      + +   + VA+KIF    + K+SW  E  VYS L    H NILK+  AE+R  +  TELWL+ E++ LGSL +YLK + + W+D+L++ + +A GLA+LH        S  KP    +AHRD KSKN+L+K++ + CIADFGLA+     ++    + +VGT  YMAPE+LEG+INF+  +F++ID+++  LV WE++SR   +D  ++D+Q PF++ VG++P+ E ++  V  KK+RPAF E+W+    +  F  TI ECWD+D +ARLSA CV ER++ L  + +
Sbjct:  212 ELKARGRFGTVW------KAQLLNEFVAVKIFP--IQDKQSWMREQEVYS-LPLMKHENILKFTAAEKRGDNLNTELWLITEFHELGSLCDYLKGNLIAWNDMLKMAETMARGLAYLHEDIPGVKGSDGKPA---VAHRDFKSKNVLMKKDMSCCIADFGLAMKFDPGSSPGETHGQVGTRRYMAPEVLEGAINFNRDAFMRIDMYACGLVLWEIVSRCSAADGPVEDYQLPFEDEVGQHPTLEDMQDAVVHKKVRPAFKEHWLKHGGLQAFCDTIEECWDQDAEARLSAGCVEERISQLVRLTA 504

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BLAST of Receptor protein serine/threonine kinase vs. TrEMBL
Match: T1HXB4 (Serine/threonine-protein kinase receptor (Fragment) OS=Rhodnius prolixus OX=13249 PE=3 SV=1)

HSP 1 Score: 249.21 bits (635), Expect = 1.286e-72
Identity = 123/294 (41.84%), Postives = 187/294 (63.61%), Query Frame = 3

Query:  729 QLLAQGRFGQVWSGIIETRNEHKKQIVAIKIFSDNKEGKKSWRNESTVYSILQNGPHPNILKYFGAERRMKDSITELWLVVEYYPLGSLWNYLKKSTVTWSDLLQICQNIAAGLAHLHSFSKPINS-----PIAHRDIKSKNILLKENYTACIADFGLAICHQNTD--NSFNNRVGTLSYMAPEILEGSINFDIYSFLKIDIFSMSLVFWEVLSRFQFSDLHIKDFQNPFQEIVGENPSFEQLRQCVTIKKLRPAFNENWINLPDVIKFWKTITECWDEDPDARLSAECVLERM 1589
            ++ A+GRFG VW      + ++K ++VA+KIF  +   K+SW++E  ++  L +  H +IL+Y G E+R     +E WL+  Y+ LGSL +YLK + +TW+ L  + ++++ GL HLH    P  +      IAHRD KSKN+LLK + TACIADFGLA+  Q        + +VGT  YMAPE+LEG+INF   +FL+ID+++  LV WE+ +R    D  + ++Q PF+E VG++P+ E +++CV  KK RP    +W + P ++    T+ ECWD D +ARLSA CV+ER+
Sbjct:  170 EVKAKGRFGAVW------KAQYKTELVAVKIFPVHD--KQSWQSEQEIFK-LAHMRHDSILRYIGVEKRGDGLQSEYWLITAYHDLGSLCDYLKANNLTWAQLCHVAESMSRGLMHLHEEMGPTKTEGYKPAIAHRDFKSKNVLLKSDLTACIADFGLALVFQPGKPCGDTHGQVGTRRYMAPEVLEGAINFSRDAFLRIDMYACGLVLWELATRCTAQDSAVGEYQLPFEEEVGQHPTLEDMQECVVHKKQRPLLKNSWKSHPGLLALCDTMEECWDHDAEARLSASCVMERI 454

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BLAST of Receptor protein serine/threonine kinase vs. TrEMBL
Match: O13102 (Serine/threonine-protein kinase receptor OS=Carassius auratus OX=7957 PE=2 SV=1)

HSP 1 Score: 249.98 bits (637), Expect = 1.302e-72
Identity = 126/298 (42.28%), Postives = 190/298 (63.76%), Query Frame = 3

Query:  729 QLLAQGRFGQVWSGIIETRNEHKKQIVAIKIFSDNKEGKKSWRNESTVYSILQNGPHPNILKYFGAERRMKDSITELWLVVEYYPLGSLWNYLKKSTVTWSDLLQICQNIAAGLAHLHSFSKPINSPIAHRDIKSKNILLKENYTACIADFGLAICHQ--NTDNSFNNRVGTLSYMAPEILEGSINFDIYSFLKIDIFSMSLVFWEVLSRFQFSDLHIKDFQNPFQEIVGENPSFEQLRQCVTIKKLRPAFNENWINLPDVIKFWKTITECWDEDPDARLSAECVLERMNDLCNINSI 1616
            ++ A+GRFGQVW      R +   + VA+KIF    + K+SW+NE  ++S      H N+L+Y GAERR  +  TE WL+ E++  GSL ++LK + ++W+DL  I + +A GLA+LH         IAHRD KS+N+LLK + +A + D GLA+  +        + +VGT  YMAPE+LEG+INF   SFL+ID+++M LV WE++SR + +D  + ++  PF+E +G++PS E L+  V  KK+RPAF + W+    + +  +TI ECWD D +ARLSA CV ER++ +  + SI
Sbjct:  192 EVKARGRFGQVW------RAQMMNECVAVKIFP--IQDKQSWQNERDMFST-PGMKHENLLRYIGAERRGANLETEFWLITEFHERGSLTDHLKGNVLSWTDLCHIAETMACGLAYLHEDVPRSKPAIAHRDFKSRNVLLKSDLSAVLGDLGLAVRFEPGTPPGDTHGQVGTRRYMAPEVLEGAINFQRDSFLRIDMYAMGLVLWELVSRCRAADGPVDEYMLPFEEEIGQHPSLEDLQDAVVHKKMRPAFKDCWLKHSGLAQMCETIEECWDHDAEARLSAGCVEERISQIRRLTSI 480

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BLAST of Receptor protein serine/threonine kinase vs. Ensembl Cavefish
Match: acvr2ab (activin receptor type-2A [Source:NCBI gene;Acc:103040899])

HSP 1 Score: 247.669 bits (631), Expect = 6.405e-75
Identity = 166/464 (35.78%), Postives = 239/464 (51.51%), Query Frame = 3

Query:  258 QSCWEWPNTSDCPDEAGPCYLLGHNTKQPACCCKGNLCNDISVKYSIKFPKVYTTINP--------QSLV--MIPNTGQVNI----FWIYXXXXXXXXXXXXXXXXXXKRFAIHSKTSINSNRKIFDVENINDNVRTPIAKLCENGSRYEENTVLINQISTENLYSLCDKNQLLAQGRFGQVWSGIIETRNEHKKQIVAIKIFSDNKEGKKSWRNESTVYSILQNGPHPNILKYFGAERRMKDSITELWLVVEYYPLGSLWNYLKKSTVTWSDLLQICQNIAAGLAHLH----SFSKPINSPIAHRDIKSKNILLKENYTACIADFGLAICHQ--NTDNSFNNRVGTLSYMAPEILEGSINFDIYSFLKIDIFSMSLVFWEVLSRFQFSDLHIKDFQNPFQEIVGENPSFEQLRQCVTIKKLRPAFNENWINLPDVIKFWKTITECWDEDPDARLSAECVLERM 1589
            Q CW   +  +C D +G C     + +   CCC+GN+CN+  + YS     V TT+NP         +L+  ++P  G   I    FW+Y                  +   +     +   +  F +  I D   TP + L             + Q   + L       ++ A+GRFG VW    +  NEH    VA+KIF    + K+SW+NE  +Y I     H N+L + GAE+R      ELWL+  Y+  GSL +YLK + V+W++L  I Q  A GLA+LH             IAHRDIKSKNIL+K N TACIADFGLA+  +   +    + +VGT  YMAPE+LEG+INF   +FL+ID++++ LV WE+  R   +D  + ++  PF+E VG++PS E +++ V  KKLRP   E W     +    +TI ECWD + +ARLSA CV ER+
Sbjct:   76 QGCWL--DDVNCYD-SGECVERKDSPEVFFCCCEGNMCNE-KIYYSPDTQAVQTTLNPYPPKPELCSTLLYSLVPIMGIAAILLFSFWMY------------------RHHKLAYPPVLVPTQHAFHI-MIEDPGPTPPSPL-------------LGQKPLQLL-------EVKARGRFGCVWKA--QLLNEH----VAVKIFP--IQNKQSWQNEYEIYCI-SGMKHENLLNFIGAEKRGNGMDIELWLITSYHEKGSLTDYLKANVVSWNELCHIAQTFARGLAYLHEDIPGLKDGHKPAIAHRDIKSKNILMKTNLTACIADFGLALKFEAGKSAGDTHGQVGTRRYMAPEVLEGAINFQRDAFLRIDMYAVGLVLWELAFRCTAADGPVDEYALPFEEEVGQHPSLEDMQEVVVHKKLRPTLREYWQKHTGLAMLCETIEECWDHEAEARLSAGCVEERI 487

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BLAST of Receptor protein serine/threonine kinase vs. Ensembl Cavefish
Match: acvr2aa (activin receptor type-2A-like [Source:NCBI gene;Acc:103032572])

HSP 1 Score: 239.58 bits (610), Expect = 5.853e-72
Identity = 130/302 (43.05%), Postives = 187/302 (61.92%), Query Frame = 3

Query:  729 QLLAQGRFGQVWSGIIETRNEHKKQIVAIKIFSDNKEGKKSWRNESTVYSILQNGPHPNILKYFGAERRMKDSITELWLVVEYYPLGSLWNYLKKSTVTWSDLLQICQNIAAGLAHLHS----FSKPINSPIAHRDIKSKNILLKENYTACIADFGLAICHQ--NTDNSFNNRVGTLSYMAPEILEGSINFDIYSFLKIDIFSMSLVFWEVLSRFQFSDLHIKDFQNPFQEIVGENPSFEQLRQCVTIKKLRPAFNENWINLPDVIKFWKTITECWDEDPDARLSAECVLERMNDLCNINSI 1616
            ++ A+GRFG VW    +  N++    VA+KIF    + K+SW+NE  +Y+ L    H NIL + GAE+R  +   ELWL+  Y+  GSL +YLK + VTW++L  I Q +A GLA+LH+            +AHRDIKSKN+LLK N T CIADFGLA+  +   +    + +VGT  YMAPE+LEG+INF   +FL+ID++++ LV WE+ SR   +D  + ++  PF+E VG++P+ E +++ V  KKLRP   E W     +    +TI ECWD + +ARLSA CV ER+  +    SI
Sbjct:  196 EVKARGRFGCVWKA--QLLNDY----VAVKIFP--IQDKQSWQNEYEIYN-LPGMRHENILHFMGAEKRGANLDIELWLITAYHEKGSLTDYLKANVVTWNELCHIAQTMARGLAYLHADIPGLRDGHKPAVAHRDIKSKNVLLKANLTVCIADFGLALRFEAGKSAGDTHGQVGTRRYMAPEVLEGAINFQRDAFLRIDMYAVGLVLWELASRCTAADGPVDEYMLPFEEEVGQHPTLEDMQEVVVHKKLRPTLRECWQKHAGLTMLCETIEECWDHEAEARLSAGCVEERVVQMQRQTSI 488

[Close]

BLAST of Receptor protein serine/threonine kinase vs. Ensembl Cavefish
Match: acvr2ab (activin receptor type-2A [Source:NCBI gene;Acc:103040899])

HSP 1 Score: 239.195 bits (609), Expect = 6.372e-72
Identity = 130/293 (44.37%), Postives = 180/293 (61.43%), Query Frame = 3

Query:  729 QLLAQGRFGQVWSGIIETRNEHKKQIVAIKIFSDNKEGKKSWRNESTVYSILQNGPHPNILKYFGAERRMKDSITELWLVVEYYPLGSLWNYLKKSTVTWSDLLQICQNIAAGLAHLH----SFSKPINSPIAHRDIKSKNILLKENYTACIADFGLAICHQ--NTDNSFNNRVGTLSYMAPEILEGSINFDIYSFLKIDIFSMSLVFWEVLSRFQFSDLHIKDFQNPFQEIVGENPSFEQLRQCVTIKKLRPAFNENWINLPDVIKFWKTITECWDEDPDARLSAECVLERM 1589
            ++ A+GRFG VW    +  NEH    VA+KIF    + K+SW+NE  +Y I     H N+L + GAE+R      ELWL+  Y+  GSL +YLK + V+W++L  I Q  A GLA+LH             IAHRDIKSKNIL+K N TACIADFGLA+  +   +    + +VGT  YMAPE+LEG+INF   +FL+ID++++ LV WE+  R   +D  + ++  PF+E VG++PS E +++ V  KKLRP   E W     +    +TI ECWD + +ARLSA CV ER+
Sbjct:  190 EVKARGRFGCVWKA--QLLNEH----VAVKIFP--IQNKQSWQNEYEIYCI-SGMKHENLLNFIGAEKRGNGMDIELWLITSYHEKGSLTDYLKANVVSWNELCHIAQTFARGLAYLHEDIPGLKDGHKPAIAHRDIKSKNILMKTNLTACIADFGLALKFEAGKSAGDTHGQVGTRRYMAPEVLEGAINFQRDAFLRIDMYAVGLVLWELAFRCTAADGPVDEYALPFEEEVGQHPSLEDMQEVVVHKKLRPTLREYWQKHTGLAMLCETIEECWDHEAEARLSAGCVEERI 473

[Close]

BLAST of Receptor protein serine/threonine kinase vs. Ensembl Cavefish
Match: acvr2ab (activin receptor type-2A [Source:NCBI gene;Acc:103040899])

HSP 1 Score: 239.58 bits (610), Expect = 6.780e-72
Identity = 130/293 (44.37%), Postives = 180/293 (61.43%), Query Frame = 3

Query:  729 QLLAQGRFGQVWSGIIETRNEHKKQIVAIKIFSDNKEGKKSWRNESTVYSILQNGPHPNILKYFGAERRMKDSITELWLVVEYYPLGSLWNYLKKSTVTWSDLLQICQNIAAGLAHLH----SFSKPINSPIAHRDIKSKNILLKENYTACIADFGLAICHQ--NTDNSFNNRVGTLSYMAPEILEGSINFDIYSFLKIDIFSMSLVFWEVLSRFQFSDLHIKDFQNPFQEIVGENPSFEQLRQCVTIKKLRPAFNENWINLPDVIKFWKTITECWDEDPDARLSAECVLERM 1589
            ++ A+GRFG VW    +  NEH    VA+KIF    + K+SW+NE  +Y I     H N+L + GAE+R      ELWL+  Y+  GSL +YLK + V+W++L  I Q  A GLA+LH             IAHRDIKSKNIL+K N TACIADFGLA+  +   +    + +VGT  YMAPE+LEG+INF   +FL+ID++++ LV WE+  R   +D  + ++  PF+E VG++PS E +++ V  KKLRP   E W     +    +TI ECWD + +ARLSA CV ER+
Sbjct:  196 EVKARGRFGCVWKA--QLLNEH----VAVKIFP--IQNKQSWQNEYEIYCI-SGMKHENLLNFIGAEKRGNGMDIELWLITSYHEKGSLTDYLKANVVSWNELCHIAQTFARGLAYLHEDIPGLKDGHKPAIAHRDIKSKNILMKTNLTACIADFGLALKFEAGKSAGDTHGQVGTRRYMAPEVLEGAINFQRDAFLRIDMYAVGLVLWELAFRCTAADGPVDEYALPFEEEVGQHPSLEDMQEVVVHKKLRPTLREYWQKHTGLAMLCETIEECWDHEAEARLSAGCVEERI 479

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BLAST of Receptor protein serine/threonine kinase vs. Ensembl Cavefish
Match: acvr2aa (activin receptor type-2A-like [Source:NCBI gene;Acc:103032572])

HSP 1 Score: 239.195 bits (609), Expect = 9.829e-72
Identity = 130/302 (43.05%), Postives = 187/302 (61.92%), Query Frame = 3

Query:  729 QLLAQGRFGQVWSGIIETRNEHKKQIVAIKIFSDNKEGKKSWRNESTVYSILQNGPHPNILKYFGAERRMKDSITELWLVVEYYPLGSLWNYLKKSTVTWSDLLQICQNIAAGLAHLHS----FSKPINSPIAHRDIKSKNILLKENYTACIADFGLAICHQ--NTDNSFNNRVGTLSYMAPEILEGSINFDIYSFLKIDIFSMSLVFWEVLSRFQFSDLHIKDFQNPFQEIVGENPSFEQLRQCVTIKKLRPAFNENWINLPDVIKFWKTITECWDEDPDARLSAECVLERMNDLCNINSI 1616
            ++ A+GRFG VW    +  N++    VA+KIF    + K+SW+NE  +Y+ L    H NIL + GAE+R  +   ELWL+  Y+  GSL +YLK + VTW++L  I Q +A GLA+LH+            +AHRDIKSKN+LLK N T CIADFGLA+  +   +    + +VGT  YMAPE+LEG+INF   +FL+ID++++ LV WE+ SR   +D  + ++  PF+E VG++P+ E +++ V  KKLRP   E W     +    +TI ECWD + +ARLSA CV ER+  +    SI
Sbjct:  204 EVKARGRFGCVWKA--QLLNDY----VAVKIFP--IQDKQSWQNEYEIYN-LPGMRHENILHFMGAEKRGANLDIELWLITAYHEKGSLTDYLKANVVTWNELCHIAQTMARGLAYLHADIPGLRDGHKPAVAHRDIKSKNVLLKANLTVCIADFGLALRFEAGKSAGDTHGQVGTRRYMAPEVLEGAINFQRDAFLRIDMYAVGLVLWELASRCTAADGPVDEYMLPFEEEVGQHPTLEDMQEVVVHKKLRPTLRECWQKHAGLTMLCETIEECWDHEAEARLSAGCVEERVVQMQRQTSI 496

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BLAST of Receptor protein serine/threonine kinase vs. Ensembl Sea Lamprey
Match: ACVR2B (activin A receptor type 2B [Source:HGNC Symbol;Acc:HGNC:174])

HSP 1 Score: 219.164 bits (557), Expect = 5.017e-65
Identity = 116/300 (38.67%), Postives = 176/300 (58.67%), Query Frame = 3

Query:  729 QLLAQGRFGQVWSGIIETRNEHKKQIVAIKIFSDNKEGKKSWRNESTVYSILQNGPHPNILKYFGAERRMKDSITELWLVVEYYPLGSLWNYLKKSTVTWSDLLQICQNIAAGLAHLHS-----FSKPINSPIAHRDIKSKNILLKENYTACIADFGLAI--CHQNTDNSFNNRVGTLSYMAPEILEGSINFDIYSFLKIDIFSMSLVFWEVLSRFQFSDLHIKDFQNPFQEIVGENPSFEQLRQCVTIKKLRPAFNENWINLPDVIKFWKTITECWDEDPDARLSAECVLERMNDLCNI 1607
            ++ A G FG VW   +         +VA+KIF+  +  ++SW NE  ++       H N+L +  AE+R+    TE WL+  ++  GSL  YLK + ++W +L  + + +A GLA+LH        + I   IAHRDIKS+NILLK + TACIADFGLA+           + +VGTL YMAPEILEG+I+F   SFL+ID++++ LV WE+  R    +  + +F  PF+E +G++ S E+++  V  K++RP   + W   P +    +T+ ECWD + +ARLSA CV ER+  +  I
Sbjct:  191 EVKAMGHFGSVWKARL------LGDLVAVKIFTVKE--RRSWENEIDIFKT-AGVAHENLLHFIAAEKRVSGLDTEYWLITTFHEKGSLAEYLKGNVLSWRELCHVAETMARGLAYLHEDIVSPKGELIKPAIAHRDIKSRNILLKGDLTACIADFGLAVKFAPGKPAGDTHGQVGTLRYMAPEILEGAIHFQRDSFLRIDVYALGLVLWELAWRCTVIEERVGEFSLPFEEELGKHLSLEEMQDLVVQKRVRPTMKDCWRKHPGMSLLCETMEECWDHEAEARLSAGCVEERVQTMRRI 481

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BLAST of Receptor protein serine/threonine kinase vs. Ensembl Sea Lamprey
Match: ACVR2B (activin A receptor type 2B [Source:HGNC Symbol;Acc:HGNC:174])

HSP 1 Score: 212.616 bits (540), Expect = 7.083e-63
Identity = 112/295 (37.97%), Postives = 177/295 (60.00%), Query Frame = 3

Query:  729 QLLAQGRFGQVWSGIIETRNEHKKQIVAIKIFSDNKEGKKSWRNESTVYSILQNGPHPNILKYFGAERRMKDSITELWLVVEYYPLGSLWNYLKKSTVTWSDLLQICQNIAAGLAHLHSFS-----KPINSPIAHRDIKSKNILLKENYTACIADFGLAICHQ--NTDNSFNNRVGTLSYMAPEILEGSINFDIYSFLKIDIFSMSLVFWEVLSRFQFSDLHIKDFQNPFQEIVGENPSFEQLRQCVTIKKLRPAFNENWINLPDVIKFWKTITECWDEDPDARLSAECVLERMN 1592
            ++ A GR+G VW   + +        VA+K+F+   +  +SW  E  +YS      H N+L++  AE+R+     E W++  ++  GSL  YLK + +TW +L  I + ++ GLA+LH  +     + +   IAHRD+KS+N+LLK + TACIADFGLA+  +        + +VGT+ YMAPE+LEG+I+F   +FL+IDI+++ LV WE+ SR    D  + D+  PF+E +G + S +++++ V  K++RPA    W     +  F +TI ECWD + +ARLSA CV ER+ 
Sbjct:  179 EVKAVGRYGSVWKAQLFS------DYVAVKVFT--AKDLRSWEKEVDIYSS-PGIKHDNLLQFIAAEQRVSGLDVEYWIITAFHEKGSLMEYLKGNVLTWRELCLITETMSRGLAYLHEDAMGPKGELLKPSIAHRDMKSRNVLLKSDLTACIADFGLAVRFEPGKPPGDTHGQVGTMRYMAPEVLEGAIHFQRDAFLRIDIYALGLVLWELTSRCTAVDGPVGDYTLPFEEELGRHASLDEIQELVVQKRIRPALKPCWRKHALLRFFCETIEECWDHEAEARLSAGCVEERVQ 464

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BLAST of Receptor protein serine/threonine kinase vs. Ensembl Sea Lamprey
Match: ENSPMAT00000006012.1 (pep scaffold:Pmarinus_7.0:GL476493:425401:440684:1 gene:ENSPMAG00000005387.1 transcript:ENSPMAT00000006012.1 gene_biotype:protein_coding transcript_biotype:protein_coding)

HSP 1 Score: 202.216 bits (513), Expect = 1.329e-58
Identity = 115/305 (37.70%), Postives = 180/305 (59.02%), Query Frame = 3

Query:  735 LAQGRFGQVWSGIIETRNEHKKQIVAIKIFSDNKEGKKSWRNESTVYSILQNGPHPNILKYFGAERRMKDSITELWLVVEYYPLGSLWNYLKKSTVTWSDLLQICQNIAAGLAHLH-----SFSKPINSPIAHRDIKSKNILLKENYTACIADFGLAICHQNTDNSF----NNRVGTLSYMAPEILEGSINFDIY-SFLKIDIFSMSLVFWEVLSRFQFSDLHIKDFQNPFQEIVGENPSFEQLRQCVTIKKLRPAFNENWINLPDVIKFWKTITECWDEDPDARLSAECVLERMNDLCNINSIE 1619
            + +GRFG+VW      R   + + VA+KIFS  +E  +SW  E+ +Y  +    H NIL +  A+ +   + T+LWLV +Y+ LGSL++YL + +++  +L++   ++A+GLAHLH     +  KP    IAHRDIKSKNIL+K N T CIAD GLA+ H +T +S     NNRVGT  YMAPE+L+ +IN   + SF + DI++  LV WE+  R     +  +D+Q P+ ++V  +PS + +R+ V  + LRP     W +   +    + + ECW  +  ARL+A  V + ++ L  +  I+
Sbjct:  214 IGKGRFGEVW------RGRWRGEDVAVKIFSSREE--RSWFREAEIYQTVMLR-HENILGFIAADNKDNGTWTQLWLVSDYHELGSLFDYLNRFSLSVEELVKFSLSVASGLAHLHMDIVGTQGKP---AIAHRDIKSKNILVKRNRTCCIADLGLAVRHDSTTDSIDIAPNNRVGTKRYMAPEVLDDTINMKHFDSFKRGDIYAFGLVLWEISRRCVVGGI-TEDYQLPYHDMVSPDPSVDDMRRVVCEQSLRPNVPNRWQSSESLRVMGRVMRECWYANASARLTALRVKKSLSQLSQLEDIK 505

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BLAST of Receptor protein serine/threonine kinase vs. Ensembl Sea Lamprey
Match: ENSPMAT00000009742.1 (pep scaffold:Pmarinus_7.0:GL481861:10:12380:1 gene:ENSPMAG00000008794.1 transcript:ENSPMAT00000009742.1 gene_biotype:protein_coding transcript_biotype:protein_coding)

HSP 1 Score: 192.586 bits (488), Expect = 5.086e-58
Identity = 90/205 (43.90%), Postives = 133/205 (64.88%), Query Frame = 3

Query:  987 GSLWNYLKKSTVTWSDLLQICQNIAAGLAHLHSFSKPINSPIAHRDIKSKNILLKENYTACIADFGLAICHQ--NTDNSFNNRVGTLSYMAPEILEGSINFDIYSFLKIDIFSMSLVFWEVLSRFQFSDLH--IKDFQNPFQEIVGENPSFEQLRQCVTIKKLRPAFNENWINLPDVIKFWKTITECWDEDPDARLSAECVLERM 1589
            GS+ +YLK   VTWS+L  I + +A GL+ LH     +   IAHRD KSKN+LLK + TAC+AD GLA+  +        + +VGT  YMAPE+LEG+INF   +FL+ID++++ LV WE++SR   +     + D++ PF++  G++PS E +++ V  KK RPA  + W   P + +  +T+ ECWD D +ARLSA CV+ER+
Sbjct:    2 GSVGDYLKGIVVTWSELCHIAETMARGLSFLHEEGPDLKPAIAHRDFKSKNVLLKSDLTACVADLGLAVKFEPGKPPGDMHGQVGTRRYMAPEVLEGAINFQRDAFLRIDMYAVGLVMWELVSRCTVAARAGPVGDYRMPFEDEAGQHPSLEDMQEVVVNKKQRPALRDCWRKHPGLSQLCETVEECWDHDAEARLSAGCVVERV 206

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BLAST of Receptor protein serine/threonine kinase vs. Ensembl Sea Lamprey
Match: ENSPMAT00000005861.1 (pep scaffold:Pmarinus_7.0:GL476493:320276:325221:1 gene:ENSPMAG00000005274.1 transcript:ENSPMAT00000005861.1 gene_biotype:protein_coding transcript_biotype:protein_coding)

HSP 1 Score: 195.282 bits (495), Expect = 6.671e-58
Identity = 105/288 (36.46%), Postives = 174/288 (60.42%), Query Frame = 3

Query:  729 QLLAQGRFGQVWSGIIETRNEHKKQIVAIKIFSDNKEGKKSWRNESTVY-SILQNGPHPNILKYFGAERRMKDSITELWLVVEYYPLGSLWNYLKKSTVTWSDLLQICQNIAAGLAHLHS--FSKPINSPIAHRDIKSKNILLKENYTACIADFGLAICHQNT----DNSFNNRVGTLSYMAPEILEGSINFDIY-SFLKIDIFSMSLVFWEVLSRFQFSDLHIKDFQNPFQEIVGENPSFEQLRQCVTIKKLRPAFNENWINLPDVIKFWKTITECWDEDPDARLSA 1568
            + + +GR+G+VW G  +  N      VA+KIFS   E  KSW  E+ +Y ++L    H NIL +  ++   ++S T+LWL+  Y+  GSL+++L++  +  S  L++  ++AAGL+HLH   F       IAHRD+KSKNIL+K N   CIAD GLA+ H       D   N RVGT+ +MAPE+L+ ++  D + ++ + DI+++ LV WE+ +R   S+   ++++ PF + V  +PSF+++++ V +++ RP     W + P +    K + ECW ++P ARL+A
Sbjct:   31 ECVGKGRYGEVWRGQWQGEN------VAVKIFSSRDE--KSWCRETEIYNTVLLR--HENILGFIASDMTSRNSSTQLWLITHYHECGSLYDWLQRWPLEASSCLRLALSVAAGLSHLHGEIFGTHGKPAIAHRDLKSKNILVKGNGQCCIADLGLAVMHSQEWSRLDIGQNPRVGTVRFMAPEVLDETLQTDCFDAYKRADIWALGLVLWEI-ARRTLSNGIAEEYRVPFHDAVPSDPSFDEMKKVVCVEQQRPNIPNRWFSDPSLTALAKLMKECWYQNPSARLTA 307

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BLAST of Receptor protein serine/threonine kinase vs. Ensembl Yeast
Match: KIC1 (Protein kinase of the PAK/Ste20 family, required for cell integrity; physically interacts with Cdc31p (centrin), which is a component of the spindle pole body; part of the RAM network that regulates cellular polarity and morphogenesis [Source:SGD;Acc:S000001144])

HSP 1 Score: 86.6557 bits (213), Expect = 2.854e-18
Identity = 83/301 (27.57%), Postives = 137/301 (45.51%), Query Frame = 3

Query:  702 NLYSLCDKNQLLAQGRFGQVWSGIIETRNEHKKQIVAIKIF---SDNKEGKKSWRNESTVYSILQNGPHPNILKYFGAERRMKDSITELWLVVEYYPLGSLWNYLKKSTVTWSDLLQICQNIAAGLAHLHSFSKPINSPIAHRDIKSKNILLKENYTACIADFGLAICHQNTDNSFNNRVGTLSYMAPE-ILEGSINFDIYSFLKIDIFSMSLVFWEVLSRFQFSDLHIKDFQNPFQEIVGENPSF---EQLRQCVTIKKLRPAFNENWINLPDVIKFWKTITECWDEDPDARLSAECVLE 1583
            ++ SL  + +++ +G+FG V+ G     N    ++ AIK+    SD+ E +   R    + S+ Q     NI +Y+G+   +KD  T LW+++E+   GSL + L+   +    +  I + +   L  +H  +      + HRDIK+ N+L+       + DFG+A     T        GT  +MAPE I+EG     +Y   K+DI+S+ +  +                     EI   NP +   E LR    I K +P   E+      + +F   I  C DEDP  RLSA+ +L+
Sbjct:   18 DVSSLFKRTEVIGRGKFGVVYKGY----NVKTGRVYAIKVLNLDSDSDEVEDVQREIQFLASLKQIS---NITRYYGS--YLKD--TSLWIIMEHCAGGSLRSLLRPGKIDEKYIGVIMRELLVALKCIHKDN------VIHRDIKAANVLITNEGNVKLCDFGVAAQVNQTSLRRQTMAGTPYWMAPEVIMEG-----VYYDTKVDIWSLGITTY---------------------EIATGNPPYCDVEALRAMQLIIKSKPPRLEDRSYSTSLKEF---IALCLDEDPKERLSADDLLK 272

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BLAST of Receptor protein serine/threonine kinase vs. Ensembl Yeast
Match: CDC15 (Protein kinase of the Mitotic Exit Network; localized to the spindle pole bodies at late anaphase; promotes mitotic exit by directly switching on the kinase activity of Dbf2p; required for spindle disassembly after meiosis II; relocalizes to the cytoplasm upon DNA replication stress [Source:SGD;Acc:S000000072])

HSP 1 Score: 82.0333 bits (201), Expect = 9.427e-17
Identity = 63/183 (34.43%), Postives = 97/183 (53.01%), Query Frame = 3

Query:  729 QLLAQGRFGQVWSGIIETRNEHKKQIVAIK-IFSDNKEGKKSWRNESTVYSILQNGPHPNILKYFGAERRMKDSITELWLVVEYYPLGSLWNYLKKSTVTWSD---LLQICQNIAAGLAHLHSFSKPINSPIAHRDIKSKNILLKENYTACIADFGLAICHQNTDNSFNNRVGTLSYMAPEIL 1265
            Q++ +G +G V+  I    N+H  Q+VAIK +  +N E       E    S+L+N  H NI+KY G  R+      EL++++EY   GSL   + +S+   S+      + Q +  GL +LH         + HRDIK+ NILL  + T  +ADFG++      ++S     GTL++MAPEIL
Sbjct:   29 QVIGRGSYGVVYKAI----NKHTDQVVAIKEVVYENDEELNDIMAE---ISLLKNLNHNNIVKYHGFIRKSY----ELYILLEYCANGSLRRLISRSSTGLSENESKTYVTQTLL-GLKYLHG------EGVIHRDIKAANILLSADNTVKLADFGVSTI---VNSSALTLAGTLNWMAPEIL 190

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BLAST of Receptor protein serine/threonine kinase vs. Ensembl Yeast
Match: SSK22 (MAP kinase kinase kinase of HOG1 mitogen-activated signaling pathway; functionally redundant with Ssk2p; interacts with and is activated by Ssk1p; phosphorylates Pbs2p; SSK22 has a paralog, SSK2, that arose from the whole genome duplication [Source:SGD;Acc:S000000669])

HSP 1 Score: 71.633 bits (174), Expect = 1.781e-13
Identity = 66/206 (32.04%), Postives = 92/206 (44.66%), Query Frame = 3

Query:  723 KNQLLAQGRFGQVWSGIIETRNEHKKQIVAIKIFS--DNKEGKKSW---RNESTVYSILQNGPHPNILKYFGAERRMKDSITELWLVVEYYPLGSLWNYLKKSTVTWSDLLQICQ-NIAAGLAHLHSFSKPINSPIAHRDIKSKNILLKENYTACIADFGLA--ICHQNT--------------DNSFNNRVGTLSYMAPEILEGS 1274
            K   +  G FGQV+S I    N    +I+A+K     D    KK +   + E TV  +L    HPNI++Y+G E   +D +    + +EY   GSL + L    +    + Q+    +  GLA+LH       S + HRDIK +NILL  N      DFG A  +    T                S N  +GT  YMAPE + GS
Sbjct: 1036 KRSFIGGGTFGQVYSAI----NLENGEILAVKEIKIHDTTTMKKIFPLIKEEMTVLEMLN---HPNIVQYYGVEVH-RDKVN---IFMEYCEGGSLASLLDHGRIEDEMVTQVYTFELLEGLAYLHQ------SGVVHRDIKPENILLDFNGIIKYVDFGTARTVVGSRTRTVRNAAVQDFGVETKSLNEMMGTPMYMAPETISGS 1224

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BLAST of Receptor protein serine/threonine kinase vs. Ensembl Yeast
Match: FMP48 (Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; induced by treatment with 8-methoxypsoralen and UVA irradiation [Source:SGD;Acc:S000003284])

HSP 1 Score: 70.0922 bits (170), Expect = 1.916e-13
Identity = 76/260 (29.23%), Postives = 118/260 (45.38%), Query Frame = 3

Query:  735 LAQGRFGQVWSGIIETRNEHKKQIVAIKIFSDNKEGKKSWRNESTVYSILQN-GPHPNILKYFGAERRMKDSITE---LWLVVEYYPLGSLWNYLKKSTVTWS---------DLLQICQNIAAGLAHLHSFSKPINSPIAHRDIKSKNILLKENYTACIADFGLAICHQNTDNSFNNRVGTLSYMAPEILEGSI-------NFD-----IYSFLKIDIFSMS-----LVFWEVLSRFQFSD--LHIKDF----QNPFQEI 1406
            +  G F  V+     T N +    VA+KI    K  + + +NE  V  IL +  PHPNI         M D  T+     +V+EY   G L+++L  +    S         D+ +I + + + ++  HS        IAHRDIK +NILL  N    +AD+G AI    +  S + ++GT +Y APE   G +       NFD     +Y+  + D +S+      L+F + L R   S    H+K+F    ++PF  I
Sbjct:    8 IQSGTFSTVYKAWSTTHNRY----VALKITPKYKTSEANMKNEYDVMKILSSCNPHPNICS-------MLDFYTDDSYYIMVLEYCECGDLYDFLDIAKSQGSPSSPSLIQIDMQKIIKQLCSAISFAHSLG------IAHRDIKPENILLTINGDIKLADWGHAI---QSPKSNDFQIGTDNYRAPETFSGRVSNSCFKKNFDRSSAPLYNTYQADYWSLGATIFYLMFGDCLFRVSKSKKVQHLKNFDEFEKDPFAFI 247

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BLAST of Receptor protein serine/threonine kinase vs. Ensembl Yeast
Match: GIN4 (Protein kinase involved in bud growth and assembly of the septin ring; proposed to have kinase-dependent and kinase-independent activities; undergoes autophosphorylation; similar to Hsl1p; GIN4 has a paralog, KCC4, that arose from the whole genome duplication [Source:SGD;Acc:S000002915])

HSP 1 Score: 68.9366 bits (167), Expect = 1.167e-12
Identity = 56/211 (26.54%), Postives = 102/211 (48.34%), Query Frame = 3

Query:  897 HPNILKYFGAERRMKDSITELWLVVEYYPLGSLWNYL-KKSTVTWSDLLQICQNIAAGLAHLHSFSKPINSPIAHRDIKSKNILLKENYTACIADFGLAICHQNTDNSFNNRVGTLSYMAPEILEGSINFDIYSFLKIDIFSMSLVFWEVLSR---FQFSDLHIKDFQNPFQEIVGENPSFEQLRQCVT--IKKLRPAFNENWINLPDVIK 1511
            HPN+L+ +     + ++ T+L+LV+EY   G L+N L ++  +   + ++  + I  G+++ H+        I HRD+K +N+LL   Y   IADFG+A   +          G+  Y APEI+ G      Y     D++S  ++ + +L+    F   D +I+      Q+   E PS +++ +     I+K+     E  I   D++K
Sbjct:   90 HPNVLRLYD----VWETNTDLYLVLEYAEKGELFNLLVERGPLPEHEAIRFFRQIIIGVSYCHALG------IVHRDLKPENLLLDHKYNIKIADFGMAAL-ETEGKLLETSCGSPHYAAPEIVSGI----PYQGFASDVWSCGVILFALLTGRLPFDEEDGNIRTLLLKVQKGEFEMPSDDEISREAQDLIRKILTVDPERRIKTRDILK 285

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BLAST of Receptor protein serine/threonine kinase vs. Ensembl Nematostella
Match: EDO49370 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7RG69])

HSP 1 Score: 214.542 bits (545), Expect = 1.984e-63
Identity = 118/303 (38.94%), Postives = 185/303 (61.06%), Query Frame = 3

Query:  729 QLLAQGRFG-QVWSGIIETRNEHKKQIVAIKIFSDNKEGKKSWRNESTVYSILQNGPHPNILKYFGAERRMKDSI-----TELWLVVEYYPLGSLWNYLKKSTVTWSDLLQICQNIAAGLAHLHSFSKPINSP-----IAHRDIKSKNILLKENYTACIADFGLAICHQNTD--NSFNNRVGTLSYMAPEILEGSINFDIYSFLKIDIFSMSLVFWEVLSRFQFSDLHIKDFQNPFQEIVGENPSFEQLRQCVTIKKLRPAFNENWINLPDVIKFWKTITECWDEDPDARLSAECVLERMNDL 1598
            ++++QG+FG  VW      + ++    VA+KIF   +    +W NE   Y  L    H N+L + G E   +        TE WL+ +++  GSL ++LK+ ++  ++LLQ+  ++  GLA+LHS    IN+      IAHRD+KSKNIL+K + T CI+DFGLA+    +D     + +VGT  YMAPE+LEG+I+F   SFL+ID+++  LV WE+LSRF   D  ++D++ PF++ VG +PS E ++Q V  KK+RP F ++W     +    +TI ECWD+D +ARL++ CV +R+  +
Sbjct:  148 EVVSQGQFGVTVW------KAKYSINTVAVKIFPHQE--FTAWVNERDFYK-LCGLDHENVLTFIGDEVHHESQYNGQIYTEYWLITDFHENGSLSDFLKQRSLDLAELLQLASSVCDGLAYLHSDVPAINNSSHKPCIAHRDVKSKNILVKSDLTCCISDFGLALKFDQSDKLGETHGQVGTKRYMAPEVLEGAISFTRESFLRIDMYACGLVLWELLSRFSVHDDPVEDYRLPFEQEVGLHPSLEDMQQVVVQKKMRPQFKDSWRCHAALRVIIQTIEECWDQDGEARLTSHCVAQRLKQV 441

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BLAST of Receptor protein serine/threonine kinase vs. Ensembl Nematostella
Match: EDO41379 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7S4E9])

HSP 1 Score: 203.371 bits (516), Expect = 4.751e-60
Identity = 119/301 (39.53%), Postives = 178/301 (59.14%), Query Frame = 3

Query:  726 NQLLAQGRFGQVWSGIIETRNEHKKQIVAIKIFSDNKEGKKSWRNESTVYSILQNGPHPNILKYFGAERRMKDSITELWLVVEYYPLGSLWNYLKKSTVTWSDLLQICQNIAAGLAHLHSFSKPINSP-IAHRDIKSKNILLKENYTACIADFGLAICHQNT-----DNSFNNRVGTLSYMAPEILEGSINF-DIYSFLK-IDIFSMSLVFWEVLSRFQ-FSDLHIKDFQNPFQEIVGENPSFEQLRQCVTIKKLRPAFNENWINLPDVIKFWK-TITECWDEDPDARLSAECVLERMNDL 1598
             QL+ QGR+G VW G +        +++A+K+F    E +  W+ E  ++S L +  HP+IL++F A  R  +S  E  L+ EY+P GSL NYL++ +V W ++  +  +++AGLA LH   +  N P  AHRDI SKNIL+K + +  +ADFG A+   +      D +    VGTL YMAPE+L+G++N  DI   LK ID+++MSLV WEV  R +      +  ++ PF+  +G   + E +   V  KKLRP F + W      ++F K TI +CWD+D DARL A C+ +RM+DL
Sbjct:  100 GQLIGQGRYGTVWKGTMFN------EVMAVKVF--GAEHRLFWQAEKDLFSALDH--HPSILRFFAACERETNSSPEYLLLSEYHPRGSLQNYLRQHSVCWREMCIMGSSMSAGLAFLH---QDANKPSFAHRDINSKNILVKVDGSCVLADFGFAMNVSDATKPADDGTLITEVGTLRYMAPEVLDGAVNLHDIQGALKQIDVYAMSLVIWEVSMRCEDIFGKQVPPYKAPFEAELGPMITSEHMHTYVVQKKLRPGFPDAWKRNHSGLRFLKETIEDCWDQDGDARLLALCIKDRMSDL 387

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BLAST of Receptor protein serine/threonine kinase vs. Ensembl Nematostella
Match: EDO49083 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7RI35])

HSP 1 Score: 197.978 bits (502), Expect = 1.854e-56
Identity = 108/293 (36.86%), Postives = 170/293 (58.02%), Query Frame = 3

Query:  735 LAQGRFGQVWSGIIETRNEHKKQIVAIKIFSDNKEGKKSWRNESTVYSILQNGPHPNILKYFGAERRMKDSITELWLVVEYYPLGSLWNYLKKSTVTWSDLLQICQNIAAGLAHLH--------SFSKPINSPIAHRDIKSKNILLKENYTACIADFGLAICHQNTDNSFNN------RVGTLSYMAPEILEGSINFD-IYSFLKIDIFSMSLVFWEVLSRFQFSDLHIKDFQNPFQEIVGENPSFEQLRQCVTIKKLRPAFNENWINLPDVIKFWKTITECWDEDPDARLSA 1568
            + +GR+G+VW G+      ++ + VAIKIFS   E   SW+ E+ +Y+ +    H NIL +  A+   + S T +WL++ Y+  GSL+++L +ST     L ++  + A+GLAHLH        + SKP    IAHRDIKSKNIL+K NYT  + D GLA+ +    +S +        VGT  YMAPEILE +IN   I SF + D+++  LV WE+  R+    + ++++Q PF ++V  +PS +++++ V  +  RP+    W   P +    K I ECW+ +P ARL++
Sbjct:  223 IGKGRYGEVWKGV------YQGESVAIKIFSTTDEA--SWKRETEIYNTVMLR-HDNILGFIAADVHSRKSTTYMWLIMHYHEQGSLYDFLNRSTFDAETLCRLALSAASGLAHLHTEIFGTNRTGSKP---AIAHRDIKSKNILVKSNYTCAVGDLGLAVMYSQDKDSVDMGENPKIAVGTRRYMAPEILEETINAKCINSFKRADVYAFGLVLWEIARRYVSGGI-VEEYQPPFYDMVQSDPSIDEMKKVVVTENKRPSLPNRWTGDPTLQVMSKLIRECWNPNPAARLTS 502

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BLAST of Receptor protein serine/threonine kinase vs. Ensembl Nematostella
Match: EDO30434 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7T0S6])

HSP 1 Score: 193.741 bits (491), Expect = 1.971e-55
Identity = 111/290 (38.28%), Postives = 173/290 (59.66%), Query Frame = 3

Query:  729 QLLAQGRFGQVWSGIIETRNEHKKQIVAIKIFSDNKEGKKSWRNESTVYSILQNGPHPNILKYFGAERRMKDSITELWLVVEYYPLGSLWNYLKKSTVTWSDLLQICQNIAAGLAHLH-----SFSKPINSPIAHRDIKSKNILLKENYTACIADFGLAICH---QNT-DNSFNNRVGTLSYMAPEILEGSINF-DIYSFLKIDIFSMSLVFWEVLSRFQFSDLHIKDFQNPFQEIVGENPSFEQLRQCVTIKKLRPAFNENWINLPDVIKFWKTITECWDEDPDARLSA 1568
            +L+  GR+G V+      R + + + VA+KIFS  +E   SW  E+ +Y  +    H NIL +  A+ +   + T+LWL+ +Y+  GSL++YL++ T+    +L++  +IA+GLAHLH     +  KP    IAHRD+KS+NIL+K+N T CIAD GLA+CH   Q+T D  + NRVGT  YMAPE LE S    +  ++   DI++  LV WE+  R   SD   +D+Q P+ + +  +PS E++ + V ++K RP+    W+    +++  K + ECW   P+ARL A
Sbjct:  186 ELIGSGRYGDVY------RGQWRGEDVAVKIFSSREEC--SWFREAQIYQTVMLR-HENILGFIAADNKDNGAWTQLWLITDYHANGSLYDYLQRVTLDMKSMLKLTISIASGLAHLHMEIIGTQGKP---AIAHRDLKSRNILVKDNGTCCIADLGLAVCHNSEQDTLDIPYGNRVGTRRYMAPEFLEDSNQVRNFCAYKHGDIYAFGLVLWEITRRCICSD-KCEDYQLPYFDKICVDPSIEEVWKVVCLEKYRPSHPNYWLQDQVMMRVAKLMQECWHHSPEARLPA 462

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BLAST of Receptor protein serine/threonine kinase vs. Ensembl Nematostella
Match: EDO41833 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7S365])

HSP 1 Score: 178.333 bits (451), Expect = 1.520e-49
Identity = 109/311 (35.05%), Postives = 184/311 (59.16%), Query Frame = 3

Query:  729 QLLAQGRFGQVWSGIIETRNEHKKQIVAIKIFSDNKEGKKSWRNESTVY-SILQNGPHPNILKYFGAERRMKDSITELWLVVEYYPLGSLWNYLKKSTVTWSDLLQICQNIAAGLAHLHSF-----SKPINSPIAHRDIKSKNILLKENYTACIADFGLAICH----QNTD-NSFNNRVGTLSYMAPEILEGSINFDIYSFLKI-DIFSMSLVFWEVLSRFQFSDLHI-KDFQNPFQEIVGENPSFEQLRQCVTIKKLRPAFNENWINLPDVIKFWKTITECWDEDPDARLSAECVLERMNDLCN-INSIE 1619
            Q + +GR+G+VW      +     + VA+KIF  + E  KSW  E+ +Y ++L    H +IL +  ++      +T+++L+++Y+PLGSL+++L+   +      ++  + AAG+AHLH+       KP+   IAHRDIKSKNIL+KEN T CIADFGLA+ +    +  D N   NRVGT  YM+PE+L  +I+ + +S  K+ D++S +LV WE+  R    +  + ++++ P+ + V  +P+FE++++ V +++ RP     W     +    K + ECW + P ARL+A  V + ++ L + INS E
Sbjct:  214 QSVGKGRYGEVW------KARWHGEDVAVKIFLSHCE--KSWMRETEIYQTVLLR--HESILGFIASDIIGSGQVTQMYLIMDYHPLGSLYDFLRGHQLNKKITGKLAFSAAAGIAHLHAEILGTQGKPM---IAHRDIKSKNILVKENLTCCIADFGLAVKYIPETKGIDLNKDTNRVGTKRYMSPEVLSQTIDPESFSAYKMADMYSFALVLWEISRRCISDETGLCEEYEVPYFDAVSNDPTFEEMKRVVVLERRRPNIPNRWFRDEMLRTMGKLMAECWSQQPAARLTALRVKKSLSKLVSAINSHE 511

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BLAST of Receptor protein serine/threonine kinase vs. Ensembl Medaka
Match: acvr2bb (activin receptor type-2B [Source:NCBI gene;Acc:101171650])

HSP 1 Score: 243.047 bits (619), Expect = 3.384e-73
Identity = 126/302 (41.72%), Postives = 187/302 (61.92%), Query Frame = 3

Query:  729 QLLAQGRFGQVWSGIIETRNEHKKQIVAIKIFSDNKEGKKSWRNESTVYSILQNGPHPNILKYFGAERRMKDSITELWLVVEYYPLGSLWNYLKKSTVTWSDLLQICQNIAAGLAHLH----SFSKPINSP-IAHRDIKSKNILLKENYTACIADFGLAICHQ--NTDNSFNNRVGTLSYMAPEILEGSINFDIYSFLKIDIFSMSLVFWEVLSRFQFSDLHIKDFQNPFQEIVGENPSFEQLRQCVTIKKLRPAFNENWINLPDVIKFWKTITECWDEDPDARLSAECVLERMNDLCNINS 1613
            ++ A+GRFG VW   +      K + VA+KIF    + K+SW+NE  +Y +     H NIL Y  AE+      TELWL+ E++  GSL ++LK +TVTW++L  I + ++ GLA+LH    SF      P IAHRD KSKN++L+++ +A I DFGLA+C +        + +VGT  YMAPE+LEG+INF   SFL+ID+++M LV WE++SR    D  + ++  PF++ +G++PS E L+  V  KK+RP   + W+  P + +  +T+ ECWD D +ARLSA CV ER+  +    S
Sbjct:  196 EIKARGRFGCVWKAHL------KNEFVAVKIFP--VQDKQSWQNERDIY-LTPGMRHENILHYIAAEKHGASLETELWLITEFHERGSLTDHLKGNTVTWAELCHIAETMSRGLAYLHEDISSFKGEGPKPTIAHRDFKSKNVMLRDDLSAVIGDFGLAVCFEPGKPPGDTHGQVGTRRYMAPEVLEGAINFQRDSFLRIDMYAMGLVLWELVSRCTERDGTVGEYMLPFEDEIGQHPSLEDLQDVVVHKKMRPVIKDCWLKHPGLSQICETMEECWDHDAEARLSAGCVEERIGQIARTTS 488

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BLAST of Receptor protein serine/threonine kinase vs. Ensembl Medaka
Match: acvr2ba (activin receptor type-2B [Source:NCBI gene;Acc:101161926])

HSP 1 Score: 239.58 bits (610), Expect = 5.779e-72
Identity = 124/297 (41.75%), Postives = 185/297 (62.29%), Query Frame = 3

Query:  729 QLLAQGRFGQVWSGIIETRNEHKKQIVAIKIFSDNKEGKKSWRNESTVYSILQNGPHPNILKYFGAERRMKDSITELWLVVEYYPLGSLWNYLKKSTVTWSDLLQICQNIAAGLAHLHSFSKPINS-----PIAHRDIKSKNILLKENYTACIADFGLAICHQ--NTDNSFNNRVGTLSYMAPEILEGSINFDIYSFLKIDIFSMSLVFWEVLSRFQFSDLHIKDFQNPFQEIVGENPSFEQLRQCVTIKKLRPAFNENWINLPDVIKFWKTITECWDEDPDARLSAECVLERMNDL 1598
            ++ A+GRFG VW   +        + VA+KIF    + K+SW+NE+ V+       H NIL+Y GAERR      ELW++ E++  GSL ++LK + ++WS++  I + +A GLA+LH     +        IAHRD KSKNI+L+ + TA I DFGLA+  +        + +VGT  YMAPE+LEG+INF   +FL+ID+++M LV WE++SR + +D  +  +  PF+E VG++PS E L++ V  KK+RPAF E W+    +    +T+ ECWD D +ARLSA CV ER++ +
Sbjct:  190 EIKARGRFGCVWKAQL------LNEFVAVKIFP--IQNKESWQNETEVFQT-PGMKHQNILRYIGAERRGNHLEAELWIITEFHERGSLSDFLKGNAISWSEMCHIAETMACGLAYLHEDLPRLKGEGHKPAIAHRDFKSKNIILRTDLTAVIGDFGLAVLFEAGKPPGETHGQVGTRRYMAPEVLEGAINFQRDAFLRIDMYAMGLVLWELVSRCKAADGPVDQYLLPFEEEVGQHPSLEDLQEVVVHKKMRPAFKEPWLKHSGLAHICETVEECWDHDAEARLSAGCVEERISQI 477

[Close]

BLAST of Receptor protein serine/threonine kinase vs. Ensembl Medaka
Match: acvr2ba (activin receptor type-2B [Source:NCBI gene;Acc:101161926])

HSP 1 Score: 239.58 bits (610), Expect = 6.598e-72
Identity = 124/297 (41.75%), Postives = 185/297 (62.29%), Query Frame = 3

Query:  729 QLLAQGRFGQVWSGIIETRNEHKKQIVAIKIFSDNKEGKKSWRNESTVYSILQNGPHPNILKYFGAERRMKDSITELWLVVEYYPLGSLWNYLKKSTVTWSDLLQICQNIAAGLAHLHSFSKPINS-----PIAHRDIKSKNILLKENYTACIADFGLAICHQ--NTDNSFNNRVGTLSYMAPEILEGSINFDIYSFLKIDIFSMSLVFWEVLSRFQFSDLHIKDFQNPFQEIVGENPSFEQLRQCVTIKKLRPAFNENWINLPDVIKFWKTITECWDEDPDARLSAECVLERMNDL 1598
            ++ A+GRFG VW   +        + VA+KIF    + K+SW+NE+ V+       H NIL+Y GAERR      ELW++ E++  GSL ++LK + ++WS++  I + +A GLA+LH     +        IAHRD KSKNI+L+ + TA I DFGLA+  +        + +VGT  YMAPE+LEG+INF   +FL+ID+++M LV WE++SR + +D  +  +  PF+E VG++PS E L++ V  KK+RPAF E W+    +    +T+ ECWD D +ARLSA CV ER++ +
Sbjct:  192 EIKARGRFGCVWKAQL------LNEFVAVKIFP--IQNKESWQNETEVFQT-PGMKHQNILRYIGAERRGNHLEAELWIITEFHERGSLSDFLKGNAISWSEMCHIAETMACGLAYLHEDLPRLKGEGHKPAIAHRDFKSKNIILRTDLTAVIGDFGLAVLFEAGKPPGETHGQVGTRRYMAPEVLEGAINFQRDAFLRIDMYAMGLVLWELVSRCKAADGPVDQYLLPFEEEVGQHPSLEDLQEVVVHKKMRPAFKEPWLKHSGLAHICETVEECWDHDAEARLSAGCVEERISQI 479

[Close]

BLAST of Receptor protein serine/threonine kinase vs. Ensembl Medaka
Match: acvr2ab (activin A receptor type 2A [Source:NCBI gene;Acc:100049489])

HSP 1 Score: 231.106 bits (588), Expect = 1.013e-68
Identity = 126/296 (42.57%), Postives = 182/296 (61.49%), Query Frame = 3

Query:  729 QLLAQGRFGQVWSGIIETRNEHKKQIVAIKIFSDNKEGKKSWRNESTVYSILQNGPHPNILKYFGAERRMKDSITELWLVVEYYPLGSLWNYLKKSTVTWSDLLQICQNIAAGLAHLHS---FSKPINSP-IAHRDIKSKNILLKENYTACIADFGLAICHQ--NTDNSFNNRVGTLSYMAPEILEGSINFDIYSFLKIDIFSMSLVFWEVLSRFQFSDLHIKDFQNPFQEIVGENPSFEQLRQCVTIKKLRPAFNENWINLPDVIKFWKTITECWDEDPDARLSAECVLERMNDL 1598
            ++ A+GRFG VW   + +      + VA+KIF    + K SW+NE  +Y++     H NIL + G E+R  +   ELWL+  Y+  GSL ++LK + V+W++L  I Q  A GLA+LH      K  + P IAHRDIKSKN+LLK N T CIADFGLA+  +   +    + +VGT  YMAPE+LEG+INF   SFL+ID+++  LV WE+ SR   +D  + ++  PF+E VG++PS E +++ V  KKLRP   + W     +    +TI +CWD + +ARLSA CV ER+  +
Sbjct:  202 EVKARGRFGCVWKAQLLS------EYVAVKIFP--IQDKLSWQNEYEIYTV-SGMKHENILHFIGVEKRNNNLDLELWLITAYHEKGSLTDFLKANVVSWNELCHIAQTAARGLAYLHEDIPGHKDGHKPSIAHRDIKSKNLLLKSNLTICIADFGLALKFEAGKSAGDTHGQVGTRRYMAPEVLEGAINFQRDSFLRIDMYAFGLVLWELASRCTAADGPVDEYMLPFEEEVGQHPSLEDMQEVVVHKKLRPCLRDCWQKHAGLTILCETIEDCWDHEAEARLSAGCVEERIGQM 488

[Close]

BLAST of Receptor protein serine/threonine kinase vs. Ensembl Medaka
Match: acvr2ab (activin A receptor type 2A [Source:NCBI gene;Acc:100049489])

HSP 1 Score: 230.72 bits (587), Expect = 1.552e-68
Identity = 126/296 (42.57%), Postives = 182/296 (61.49%), Query Frame = 3

Query:  729 QLLAQGRFGQVWSGIIETRNEHKKQIVAIKIFSDNKEGKKSWRNESTVYSILQNGPHPNILKYFGAERRMKDSITELWLVVEYYPLGSLWNYLKKSTVTWSDLLQICQNIAAGLAHLHS---FSKPINSP-IAHRDIKSKNILLKENYTACIADFGLAICHQ--NTDNSFNNRVGTLSYMAPEILEGSINFDIYSFLKIDIFSMSLVFWEVLSRFQFSDLHIKDFQNPFQEIVGENPSFEQLRQCVTIKKLRPAFNENWINLPDVIKFWKTITECWDEDPDARLSAECVLERMNDL 1598
            ++ A+GRFG VW   + +      + VA+KIF    + K SW+NE  +Y++     H NIL + G E+R  +   ELWL+  Y+  GSL ++LK + V+W++L  I Q  A GLA+LH      K  + P IAHRDIKSKN+LLK N T CIADFGLA+  +   +    + +VGT  YMAPE+LEG+INF   SFL+ID+++  LV WE+ SR   +D  + ++  PF+E VG++PS E +++ V  KKLRP   + W     +    +TI +CWD + +ARLSA CV ER+  +
Sbjct:  210 EVKARGRFGCVWKAQLLS------EYVAVKIFP--IQDKLSWQNEYEIYTV-SGMKHENILHFIGVEKRNNNLDLELWLITAYHEKGSLTDFLKANVVSWNELCHIAQTAARGLAYLHEDIPGHKDGHKPSIAHRDIKSKNLLLKSNLTICIADFGLALKFEAGKSAGDTHGQVGTRRYMAPEVLEGAINFQRDSFLRIDMYAFGLVLWELASRCTAADGPVDEYMLPFEEEVGQHPSLEDMQEVVVHKKLRPCLRDCWQKHAGLTILCETIEDCWDHEAEARLSAGCVEERIGQM 496

[Close]

BLAST of Receptor protein serine/threonine kinase vs. Planmine SMEST
Match: SMESG000070956.1 (SMESG000070956.1)

HSP 1 Score: 1028.47 bits (2658), Expect = 0.000e+0
Identity = 521/539 (96.66%), Postives = 521/539 (96.66%), Query Frame = 3

Query:    3 LSLKRIRICSFLLIISQSYQNHRIRSVYKFNSQSIVENCEFCL*NKMWCYCTRSQHHICNESIGKIKCANGTKHCVIGLSEKGKTQSCWEWPNTSDCPDEAGPCYLLGHNTKQPACCCKGNLCNDISVKYSIKFPKVYTTINPQSLVMIPNTGQVNIFWIYXXXXXXXXXXXXXXXXXXKRFAIHSKTSINSNRKIFDVENINDNVRTPIAKLCENGSRYEENTVLINQISTENLYSLCDKNQLLAQGRFGQVWSGIIETRNEHKKQIVAIKIFSDNKEGKKSWRNESTVYSILQNGPHPNILKYFGAERRMKDSITELWLVVEYYPLGSLWNYLKKSTVTWSDLLQICQNIAAGLAHLHSFSKPINSPIAHRDIKSKNILLKENYTACIADFGLAICHQNTDNSFNNRVGTLSYMAPEILEGSINFDIYSFLKIDIFSMSLVFWEVLSRFQFSDLHIKDFQNPFQEIVGENPSFEQLRQCVTIKKLRPAFNENWINLPDVIKFWKTITECWDEDPDARLSAECVLERMNDLCNINSIE 1619
            LSLKRIRICSFLLIISQSYQNHRIRS                  NKMWCYCTRSQHHICNESIGKIKCANGTKHCVIGLSEKGKTQSCWEWPNTSDCPDEAGPCYLLGHNTKQPACCCKGNLCNDISVKYSIKFPKVYTTINPQSLVMIPNTGQVNIFWIYVVLLLAISLIASIVFIVVKRFAIHSKTSINSNRKIFDVENINDNVRTPIAKLCENGSRYEENTVLINQISTENLYSLCDKNQLLAQGRFGQVWSGIIETRNEHKKQIVAIKIFSDNKEGKKSWRNESTVYSILQNGPHPNILKYFGAERRMKDSITELWLVVEYYPLGSLWNYLKKSTVTWSDLLQICQNIAAGLAHLHSFSKPINSPIAHRDIKSKNILLKENYTACIADFGLAICHQNTDNSFNNRVGTLSYMAPEILEGSINFDIYSFLKIDIFSMSLVFWEVLSRFQFSDLHIKDFQNPFQEIVGENPSFEQLRQCVTIKKLRPAFNENWINLPDVIKFWKTITECWDEDPDARLSAECVLERMNDLCNINSIE
Sbjct:   51 LSLKRIRICSFLLIISQSYQNHRIRS------------------NKMWCYCTRSQHHICNESIGKIKCANGTKHCVIGLSEKGKTQSCWEWPNTSDCPDEAGPCYLLGHNTKQPACCCKGNLCNDISVKYSIKFPKVYTTINPQSLVMIPNTGQVNIFWIYVVLLLAISLIASIVFIVVKRFAIHSKTSINSNRKIFDVENINDNVRTPIAKLCENGSRYEENTVLINQISTENLYSLCDKNQLLAQGRFGQVWSGIIETRNEHKKQIVAIKIFSDNKEGKKSWRNESTVYSILQNGPHPNILKYFGAERRMKDSITELWLVVEYYPLGSLWNYLKKSTVTWSDLLQICQNIAAGLAHLHSFSKPINSPIAHRDIKSKNILLKENYTACIADFGLAICHQNTDNSFNNRVGTLSYMAPEILEGSINFDIYSFLKIDIFSMSLVFWEVLSRFQFSDLHIKDFQNPFQEIVGENPSFEQLRQCVTIKKLRPAFNENWINLPDVIKFWKTITECWDEDPDARLSAECVLERMNDLCNINSIE 571

[Close]

BLAST of Receptor protein serine/threonine kinase vs. Planmine SMEST
Match: SMESG000060769.1 (SMESG000060769.1)

HSP 1 Score: 219.935 bits (559), Expect = 1.475e-64
Identity = 155/474 (32.70%), Postives = 241/474 (50.84%), Query Frame = 3

Query:  264 CWEWPNTSD-CPDEAGPCYLLGHNTKQPACCCKGNLCN---DISVKYSIKFPKV---YTTINPQSLVMIPNTGQVNIFWIYXXXXXXXXXXXXXXXXXXKRFAIHSKTSINSNRKIFDVENINDNVRTPIAKLC-ENGSRYEENTVLINQISTENLYSLCDKNQLLAQGRFGQVWSG-IIETRNEHKKQIVAIKIFSDNKEGKKSWRNESTVYSILQNGPHPNILKYFGAERRMKDS-ITELWLVVEYYPLGSLWNYLKKSTVT---WSDLLQICQNIAAGLAHLHSFSKPINSP-------IAHRDIKSKNILLKENYTACIADFGLAICHQNTDN--SFNNRVGTLSYMAPEILEGSINFDIYSFLKIDIFSMSLVFWEVLSR---FQ-FSDLHIKD---FQNPFQEIVGENPSFEQLRQCVTIKKLRPAFNENWINLPDVIKFWKTITECWDEDPDARLSAECVLERMNDL 1598
            CW W + +  CP EAG C  +  N      CC G+LCN   ++S +  I+   +   + +     L+  PN+  ++I+    +  L   LI   +  + K   I  + +       ++  ++  +  T ++K+  +N S    ++     +   N Y  C+K  L   G+FG++WSG +I   +      VAIKI     E   SW  E  +Y  ++N     IL+Y G ++ + ++ I E WLV +Y   GSL++ L  S  T   W  +L +C +IA GL++LH       S        IAHRD+KS+NIL+K ++ ACIAD GLA+  Q   +    + +VGT  YMAPE+LEG+INF   SFL IDI++M+L+ WEV S+   FQ  ++    +   +  PF++ +G + + E L+  V     RP     +    D    W+TI ECWD D +ARLSA CV ER+  L
Sbjct:   23 CWMWDHENHYCPAEAGKCLSVHVNNNHKTFCCTGDLCNKPQNLSCEMKIRSISIINKFFSPTTSPLIKEPNSTFISIYIAIGIFFLMTILILIFLRGMWKNMKISMRRTFAKRETTYNGLSLMSDHNTCMSKVTSDNFSLNNHHSFSEELLKASNYYQKCEKKCL---GKFGEIWSGKLISDHSNGAIGNVAIKILRPRDES--SWETEIDMYRYIRNRC-SRILRYIGCDKIVTNNEIEEFWLVTQYIEYGSLYDCLSDSVRTKPNWFQVLNVCLDIAGGLSYLHEDGSYQTSAHISGKPSIAHRDLKSRNILIKADWKACIADLGLAVSFQGNRSLSDLHLQVGTQRYMAPEVLEGAINFSRDSFLGIDIYAMALIMWEVFSQCTDFQGLAECEASEPSVYMQPFEQELGIHITMESLQSWVVNDNKRPQLPSQYSGFSDGQSLWRTIVECWDRDAEARLSAGCVYERLMTL 490

[Close]

BLAST of Receptor protein serine/threonine kinase vs. Planmine SMEST
Match: SMESG000060769.1 (SMESG000060769.1)

HSP 1 Score: 220.32 bits (560), Expect = 2.675e-64
Identity = 155/474 (32.70%), Postives = 241/474 (50.84%), Query Frame = 3

Query:  264 CWEWPNTSD-CPDEAGPCYLLGHNTKQPACCCKGNLCN---DISVKYSIKFPKV---YTTINPQSLVMIPNTGQVNIFWIYXXXXXXXXXXXXXXXXXXKRFAIHSKTSINSNRKIFDVENINDNVRTPIAKLC-ENGSRYEENTVLINQISTENLYSLCDKNQLLAQGRFGQVWSG-IIETRNEHKKQIVAIKIFSDNKEGKKSWRNESTVYSILQNGPHPNILKYFGAERRMKDS-ITELWLVVEYYPLGSLWNYLKKSTVT---WSDLLQICQNIAAGLAHLHSFSKPINSP-------IAHRDIKSKNILLKENYTACIADFGLAICHQNTDN--SFNNRVGTLSYMAPEILEGSINFDIYSFLKIDIFSMSLVFWEVLSR---FQ-FSDLHIKD---FQNPFQEIVGENPSFEQLRQCVTIKKLRPAFNENWINLPDVIKFWKTITECWDEDPDARLSAECVLERMNDL 1598
            CW W + +  CP EAG C  +  N      CC G+LCN   ++S +  I+   +   + +     L+  PN+  ++I+    +  L   LI   +  + K   I  + +       ++  ++  +  T ++K+  +N S    ++     +   N Y  C+K  L   G+FG++WSG +I   +      VAIKI     E   SW  E  +Y  ++N     IL+Y G ++ + ++ I E WLV +Y   GSL++ L  S  T   W  +L +C +IA GL++LH       S        IAHRD+KS+NIL+K ++ ACIAD GLA+  Q   +    + +VGT  YMAPE+LEG+INF   SFL IDI++M+L+ WEV S+   FQ  ++    +   +  PF++ +G + + E L+  V     RP     +    D    W+TI ECWD D +ARLSA CV ER+  L
Sbjct:   72 CWMWDHENHYCPAEAGKCLSVHVNNNHKTFCCTGDLCNKPQNLSCEMKIRSISIINKFFSPTTSPLIKEPNSTFISIYIAIGIFFLMTILILIFLRGMWKNMKISMRRTFAKRETTYNGLSLMSDHNTCMSKVTSDNFSLNNHHSFSEELLKASNYYQKCEKKCL---GKFGEIWSGKLISDHSNGAIGNVAIKILRPRDES--SWETEIDMYRYIRNRC-SRILRYIGCDKIVTNNEIEEFWLVTQYIEYGSLYDCLSDSVRTKPNWFQVLNVCLDIAGGLSYLHEDGSYQTSAHISGKPSIAHRDLKSRNILIKADWKACIADLGLAVSFQGNRSLSDLHLQVGTQRYMAPEVLEGAINFSRDSFLGIDIYAMALIMWEVFSQCTDFQGLAECEASEPSVYMQPFEQELGIHITMESLQSWVVNDNKRPQLPSQYSGFSDGQSLWRTIVECWDRDAEARLSAGCVYERLMTL 539

[Close]

BLAST of Receptor protein serine/threonine kinase vs. Planmine SMEST
Match: SMESG000068827.1 (SMESG000068827.1)

HSP 1 Score: 190.66 bits (483), Expect = 5.612e-53
Identity = 121/319 (37.93%), Postives = 177/319 (55.49%), Query Frame = 3

Query:  729 QLLAQGRFGQVWSGIIETRNEHKKQIVAIKIFSDNKEGKKSWRNESTVYSILQNGPHPNILKYFGAERRMKDSITELWLVVEYYPLGSLWNYLKKSTVTWSDLLQICQNIAAGLAHLHSFSKPINS--PIAHRDIKSKNILLKENYTACIADFGLAIC-------HQNTDNSFNNRVGTLSYMAPEILE---------------GSINFDIYSFLKI---------------DIFSMSLVFWEVLSRFQFSDLHIKDFQNPFQEIVGENPSFEQLRQCVTIKKLRPAFNENW-INLPDVIKFWKTITECWDEDPDARLS 1565
            + + +G+FG+VW G      + + ++VA+KIFS  +E   SW  E+ +Y+ +    H NIL Y+ ++       T+LW+V++Y+PLGSL  YL  +T+T S +L++  + AAGL HLH+    +     IAHRD+KSKNIL+K+N T CIAD GLA+         Q ++N+ N  VGT  YMAPE+LE                +I+ +I S   I               D++S SLV WE+LSR  F D  I+ +Q PF E V  +PSFE++ + V  + LRP  +EN    L  V+K    + ECW + P  RLS
Sbjct:  261 ECIGKGKFGEVWKG------QFQGELVAVKIFSSREES--SWTRETNIYNTVL-LRHDNILGYYASDLISNSGCTQLWMVMQYHPLGSLHEYLSANTLTVSTVLKLAHSAAAGLCHLHTRIMGLQGKPAIAHRDVKSKNILVKKNLTCCIADLGLAVFPESMGNNEQLSENNNNRIVGTKRYMAPELLELACFLSNNQSENFNSNNIHLNISSTSSIMNIHGENYMESLKAADVYSYSLVLWEILSRTTF-DGVIQPYQLPFGENVQSDPSFEEMFKVVVEQGLRPNLSENIKAQLNPVVKI---MEECWHQRPSIRLS 566

[Close]

BLAST of Receptor protein serine/threonine kinase vs. Planmine SMEST
Match: SMESG000006023.1 (SMESG000006023.1)

HSP 1 Score: 176.792 bits (447), Expect = 1.061e-47
Identity = 111/302 (36.75%), Postives = 168/302 (55.63%), Query Frame = 3

Query:  729 QLLAQGRFGQVWSGIIETRNEHKKQIVAIKIFSDNKEGKKSWRNESTVYSILQNG-PHPNILKYFGAERRMKDSITELWLVVEYYPLGSLWNYLKKSTVTWSDLLQICQNIAAGLAHLHSFSKPINSP--IAHRDIKSKNILLKENYTACIADFGLAICHQNTDNSFN-NRVGTLSYMAPEILEGSI-------NFDIYSFLKIDIFSMSLVFWEVLSRFQFSDLHIKD--FQNPFQEIVGENPSFEQLRQCVTIKKLRPAFNENWINLPDVIKFWKTITECWDEDPDARLSAECVLERMND 1595
            Q + +GRFG VW G     N      VA+KIFS   E   SW  E  +Y   QN   H N+L +   +RR     TELWLV +Y+  GSL+ YL+   ++    +++ ++I  GLA+LH+    ++    IAHRD+KS+NIL+K     CI D GLA+      ++ + N VGT  YMAPEI+   I       N  + +F K DI+S SLV WE+L R + S L+I    ++ P+Q +V  +PS E+++  +  +K+RP  N +W NL  +    K++ E W E+P +RL+   + + MN+
Sbjct:  288 QAVGEGRFGTVWLGKWNGDN------VAVKIFSSRDE--VSWAREKDMYQ--QNFLRHSNVLGFVTTDRRDNGLATELWLVTDYHENGSLFEYLRAHIISIEQAVKMTRSITNGLAYLHTEINGLDGKPGIAHRDLKSRNILVKSCGECCIGDLGLAVRLIEDCSTLDLNNVGTRRYMAPEIILDKIVQPDMIYNGGLEAFKKADIYSYSLVIWEILRRCECSSLNISASAYEMPYQNLVSNDPSIEEMKSIICDRKIRPPINSSWDNLNPLKDISKSVRESWFEEPASRLNIMRLKKIMNN 579

The following BLAST results are available for this feature:

BLAST of Receptor protein serine/threonine kinase vs. Ensembl Human
BLAST of Receptor protein serine/threonine kinase vs. Ensembl Celegans
BLAST of Receptor protein serine/threonine kinase vs. Ensembl Fly
BLAST of Receptor protein serine/threonine kinase vs. Ensembl Zebrafish
BLAST of Receptor protein serine/threonine kinase vs. Ensembl Xenopus
BLAST of Receptor protein serine/threonine kinase vs. Ensembl Mouse
BLAST of Receptor protein serine/threonine kinase vs. UniProt/SwissProt
BLAST of Receptor protein serine/threonine kinase vs. TrEMBL
BLAST of Receptor protein serine/threonine kinase vs. Ensembl Cavefish
BLAST of Receptor protein serine/threonine kinase vs. Ensembl Sea Lamprey
BLAST of Receptor protein serine/threonine kinase vs. Ensembl Yeast
BLAST of Receptor protein serine/threonine kinase vs. Ensembl Nematostella
BLAST of Receptor protein serine/threonine kinase vs. Ensembl Medaka
BLAST of Receptor protein serine/threonine kinase vs. Planmine SMEST

BLAST of Receptor protein serine/threonine kinase vs. Ensembl Human
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Human e!99)
Total hits: 5


Match Name	E-value	Identity	Description
ACVR2A	1.565e-72	42.38	activin A receptor type 2A [Source:HGNC Symbol;Acc...	[more]
ACVR2A	2.515e-71	42.38	activin A receptor type 2A [Source:HGNC Symbol;Acc...	[more]
ACVR2A	2.515e-71	42.38	activin A receptor type 2A [Source:HGNC Symbol;Acc...	[more]
ACVR2B	3.360e-68	39.66	activin A receptor type 2B [Source:HGNC Symbol;Acc...	[more]
TGFBR2	7.227e-62	31.49	transforming growth factor beta receptor 2 [Source...	[more]

BLAST of Receptor protein serine/threonine kinase vs. Ensembl Celegans
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99)
Total hits: 5


Match Name	E-value	Identity	Description
daf-1	5.693e-46	33.44	Cell surface receptor daf-1 [Source:UniProtKB/Swi...	[more]
daf-1	3.381e-44	33.44	Cell surface receptor daf-1 [Source:UniProtKB/Swi...	[more]
daf-4	8.564e-42	34.16	Cell surface receptor daf-4 [Source:UniProtKB/Swi...	[more]
daf-4	2.086e-41	34.16	Cell surface receptor daf-4 [Source:UniProtKB/Swi...	[more]
daf-4	3.265e-41	34.38	Cell surface receptor daf-4 [Source:UniProtKB/Swi...	[more]

BLAST of Receptor protein serine/threonine kinase vs. Ensembl Fly
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99)
Total hits: 5


Match Name	E-value	Identity	Description
put	1.034e-70	43.67	gene:FBgn0003169 transcript:FBtr0334030	[more]
put	1.034e-70	43.67	gene:FBgn0003169 transcript:FBtr0082977	[more]
put	1.198e-70	43.67	gene:FBgn0003169 transcript:FBtr0330227	[more]
sax	1.680e-57	37.98	gene:FBgn0003317 transcript:FBtr0088833	[more]
sax	4.060e-57	38.33	gene:FBgn0003317 transcript:FBtr0308825	[more]

BLAST of Receptor protein serine/threonine kinase vs. Ensembl Zebrafish
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99)
Total hits: 5


Match Name	E-value	Identity	Description
acvr2bb	3.770e-72	43.33	activin A receptor type 2Bb [Source:ZFIN;Acc:ZDB-G...	[more]
acvr2aa	1.144e-71	43.71	activin A receptor type 2Aa [Source:ZFIN;Acc:ZDB-G...	[more]
acvr2aa	1.460e-71	43.71	activin A receptor type 2Aa [Source:ZFIN;Acc:ZDB-G...	[more]
acvr2aa	1.988e-71	43.71	activin A receptor type 2Aa [Source:ZFIN;Acc:ZDB-G...	[more]
acvr2ab	8.909e-68	41.06	activin A receptor type 2Ab [Source:ZFIN;Acc:ZDB-G...	[more]

BLAST of Receptor protein serine/threonine kinase vs. Ensembl Xenopus
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99)
Total hits: 5


Match Name	E-value	Identity	Description
acvr2a	4.613e-71	43.14	activin A receptor type 2A [Source:NCBI gene;Acc:1...	[more]
acvr2a	7.448e-71	43.14	activin A receptor type 2A [Source:NCBI gene;Acc:1...	[more]
acvr2a	7.866e-71	43.14	activin A receptor type 2A [Source:NCBI gene;Acc:1...	[more]
acvr2a	8.365e-71	43.14	activin A receptor type 2A [Source:NCBI gene;Acc:1...	[more]
acvr2a	8.413e-71	43.14	activin A receptor type 2A [Source:NCBI gene;Acc:1...	[more]

BLAST of Receptor protein serine/threonine kinase vs. Ensembl Mouse
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99)
Total hits: 5


Match Name	E-value	Identity	Description
Acvr2a	1.938e-71	42.38	activin receptor IIA [Source:MGI Symbol;Acc:MGI:10...	[more]
Acvr2b	4.227e-69	31.86	activin receptor IIB [Source:MGI Symbol;Acc:MGI:87...	[more]
Acvr2b	2.307e-68	39.66	activin receptor IIB [Source:MGI Symbol;Acc:MGI:87...	[more]
Acvr2b	3.331e-68	31.67	activin receptor IIB [Source:MGI Symbol;Acc:MGI:87...	[more]
Tgfbr2	1.577e-62	32.17	transforming growth factor, beta receptor II [Sour...	[more]

BLAST of Receptor protein serine/threonine kinase vs. UniProt/SwissProt
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt)
Total hits: 5


Match Name	E-value	Identity	Description
sp\|Q90669\|AVR2A_CHICK	2.026e-71	43.79	Activin receptor type-2A OS=Gallus gallus OX=9031 ...	[more]
sp\|P27039\|AVR2A_XENLA	5.513e-71	43.46	Activin receptor type-2A OS=Xenopus laevis OX=8355...	[more]
sp\|Q28043\|AVR2A_BOVIN	1.158e-70	42.38	Activin receptor type-2A OS=Bos taurus OX=9913 GN=...	[more]
sp\|P27037\|AVR2A_HUMAN	1.208e-70	42.38	Activin receptor type-2A OS=Homo sapiens OX=9606 G...	[more]
sp\|P27038\|AVR2A_MOUSE	1.356e-70	42.38	Activin receptor type-2A OS=Mus musculus OX=10090 ...	[more]

BLAST of Receptor protein serine/threonine kinase vs. TrEMBL
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL)
Total hits: 5


Match Name	E-value	Identity	Description
A0A023F3N5	7.349e-75	42.52	Serine/threonine-protein kinase receptor (Fragment...	[more]
R7TEH1	2.986e-73	42.76	Serine/threonine-protein kinase receptor OS=Capite...	[more]
A0A1S3IPV1	5.146e-73	42.95	Serine/threonine-protein kinase receptor OS=Lingul...	[more]
T1HXB4	1.286e-72	41.84	Serine/threonine-protein kinase receptor (Fragment...	[more]
O13102	1.302e-72	42.28	Serine/threonine-protein kinase receptor OS=Carass...	[more]

BLAST of Receptor protein serine/threonine kinase vs. Ensembl Cavefish
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99)
Total hits: 5


Match Name	E-value	Identity	Description
acvr2ab	6.405e-75	35.78	activin receptor type-2A [Source:NCBI gene;Acc:103...	[more]
acvr2aa	5.853e-72	43.05	activin receptor type-2A-like [Source:NCBI gene;Ac...	[more]
acvr2ab	6.372e-72	44.37	activin receptor type-2A [Source:NCBI gene;Acc:103...	[more]
acvr2ab	6.780e-72	44.37	activin receptor type-2A [Source:NCBI gene;Acc:103...	[more]
acvr2aa	9.829e-72	43.05	activin receptor type-2A-like [Source:NCBI gene;Ac...	[more]

BLAST of Receptor protein serine/threonine kinase vs. Ensembl Sea Lamprey
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99)
Total hits: 5


Match Name	E-value	Identity	Description
ACVR2B	5.017e-65	38.67	activin A receptor type 2B [Source:HGNC Symbol;Acc...	[more]
ACVR2B	7.083e-63	37.97	activin A receptor type 2B [Source:HGNC Symbol;Acc...	[more]
ENSPMAT00000006012.1	1.329e-58	37.70	pep scaffold:Pmarinus_7.0:GL476493:425401:440684:1...	[more]
ENSPMAT00000009742.1	5.086e-58	43.90	pep scaffold:Pmarinus_7.0:GL481861:10:12380:1 gene...	[more]
ENSPMAT00000005861.1	6.671e-58	36.46	pep scaffold:Pmarinus_7.0:GL476493:320276:325221:1...	[more]

BLAST of Receptor protein serine/threonine kinase vs. Ensembl Yeast
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46)
Total hits: 5


Match Name	E-value	Identity	Description
KIC1	2.854e-18	27.57	Protein kinase of the PAK/Ste20 family, required f...	[more]
CDC15	9.427e-17	34.43	Protein kinase of the Mitotic Exit Network; locali...	[more]
SSK22	1.781e-13	32.04	MAP kinase kinase kinase of HOG1 mitogen-activated...	[more]
FMP48	1.916e-13	29.23	Putative protein of unknown function; the authenti...	[more]
GIN4	1.167e-12	26.54	Protein kinase involved in bud growth and assembly...	[more]

BLAST of Receptor protein serine/threonine kinase vs. Ensembl Nematostella
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46)
Total hits: 5


Match Name	E-value	Identity	Description
EDO49370	1.984e-63	38.94	Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7...	[more]
EDO41379	4.751e-60	39.53	Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7...	[more]
EDO49083	1.854e-56	36.86	Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7...	[more]
EDO30434	1.971e-55	38.28	Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7...	[more]
EDO41833	1.520e-49	35.05	Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7...	[more]

BLAST of Receptor protein serine/threonine kinase vs. Ensembl Medaka
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99)
Total hits: 5


Match Name	E-value	Identity	Description
acvr2bb	3.384e-73	41.72	activin receptor type-2B [Source:NCBI gene;Acc:101...	[more]
acvr2ba	5.779e-72	41.75	activin receptor type-2B [Source:NCBI gene;Acc:101...	[more]
acvr2ba	6.598e-72	41.75	activin receptor type-2B [Source:NCBI gene;Acc:101...	[more]
acvr2ab	1.013e-68	42.57	activin A receptor type 2A [Source:NCBI gene;Acc:1...	[more]
acvr2ab	1.552e-68	42.57	activin A receptor type 2A [Source:NCBI gene;Acc:1...	[more]

BLAST of Receptor protein serine/threonine kinase vs. Planmine SMEST
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST)
Total hits: 5


Match Name	E-value	Identity	Description
SMESG000070956.1	0.000e+0	96.66	SMESG000070956.1	[more]
SMESG000060769.1	1.475e-64	32.70	SMESG000060769.1	[more]
SMESG000060769.1	2.675e-64	32.70	SMESG000060769.1	[more]
SMESG000068827.1	5.612e-53	37.93	SMESG000068827.1	[more]
SMESG000006023.1	1.061e-47	36.75	SMESG000006023.1	[more]

Analyses

This transcript is derived from or has results from the following analyses


Analysis Name	Date Performed
Embryonic Stages	2016-07-25
Schmidtea mediterranea smed_20140614 BLASTX Human e!99	2016-08-08
Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99	2016-08-08
Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL	2020-05-01
Schmidtea mediterranea Sexual smed_20140614 transcriptome	2016-07-25
Schmidtea mediteranean smed_20140614 Interproscan	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST	2020-05-08

Sequences

The following sequences are available for this feature:

transcript sequence
protein sequence

transcript sequence

>SMED30012283 ID=SMED30012283|Name=Receptor protein serine/threonine kinase|organism=Schmidtea mediterranea sexual|type=transcript|length=1665bp
CCTTATCTTTGAAACGAATAAGAATCTGTTCATTTTTGCTGATAATAAGC
CAATCATATCAAAATCATAGAATTCGATCCGTATATAAATTTAACTCTCA
ATCTATTGTTGAAAATTGTGAATTTTGTTTATAGAATAAAATGTGGTGTT
ATTGCACTCGATCGCAGCATCACATTTGTAACGAATCTATTGGAAAAATC
AAATGTGCAAATGGAACAAAGCATTGTGTGATTGGCTTATCAGAAAAAGG
AAAAACCCAAAGCTGCTGGGAATGGCCAAATACGTCGGATTGTCCCGATG
AAGCCGGACCGTGCTATTTATTGGGGCACAATACAAAACAACCGGCATGC
TGCTGCAAAGGAAATCTGTGCAATGATATATCTGTGAAATATTCGATAAA
ATTCCCTAAAGTTTATACAACAATAAATCCTCAATCTCTCGTCATGATTC
CCAATACCGGACAAGTAAATATATTTTGGATTTACGTCGTTCTATTATTA
GCAATCTCGTTAATTGCCTCGATTGTATTCATCGTTGTGAAAAGATTTGC
CATCCATTCTAAAACGTCTATCAATTCAAATCGGAAAATATTTGATGTAG
AAAATATAAATGACAATGTCCGAACGCCTATTGCAAAGTTGTGTGAAAAC
GGTAGCAGATATGAAGAAAATACAGTATTAATTAATCAAATTTCTACAGA
AAATTTGTATTCGTTGTGTGATAAAAACCAATTGCTAGCTCAGGGAAGAT
TCGGTCAAGTGTGGAGTGGAATTATTGAAACTAGAAACGAACACAAAAAA
CAAATTGTGGCCATTAAAATCTTTTCAGATAACAAAGAAGGGAAAAAAAG
TTGGCGAAATGAATCAACTGTTTATTCAATTTTGCAAAATGGACCTCATC
CGAACATTCTGAAATATTTTGGAGCAGAGAGAAGAATGAAAGATTCTATA
ACGGAGCTTTGGTTAGTCGTTGAATATTATCCTCTTGGCAGTTTGTGGAA
TTATTTAAAAAAGTCAACTGTCACATGGTCAGATCTTTTACAAATTTGTC
AAAATATCGCTGCTGGCTTGGCCCATTTACATAGCTTCTCAAAACCCATA
AATTCTCCAATTGCTCATCGGGATATTAAGTCGAAAAATATTTTACTCAA
AGAAAATTATACAGCTTGCATCGCAGATTTTGGTTTGGCAATTTGTCACC
AAAACACGGATAATTCATTCAATAACCGAGTTGGAACATTAAGTTACATG
GCCCCAGAAATACTTGAAGGTTCAATTAATTTTGACATTTATTCTTTTTT
GAAAATAGATATATTTTCAATGTCCTTGGTATTTTGGGAAGTATTGAGTC
GTTTTCAATTCTCTGATTTACATATTAAAGATTTTCAAAACCCTTTCCAA
GAAATTGTTGGTGAAAATCCATCATTTGAGCAGTTACGACAATGTGTGAC
GATAAAGAAATTGAGACCTGCATTCAATGAAAACTGGATAAATCTTCCAG
ATGTAATAAAATTTTGGAAAACAATTACAGAATGTTGGGATGAAGATCCA
GATGCTCGATTAAGTGCGGAGTGTGTTCTAGAAAGAATGAATGATCTTTG
TAATATTAACTCTATTGAATAATATTTTTCTATTTGATTTATTTTAAATT
CGTTTAATAAAGTCC

protein sequence of SMED30012283-orf-1

>SMED30012283-orf-1 ID=SMED30012283-orf-1|Name=SMED30012283-orf-1|organism=Schmidtea mediterranea sexual|type=polypeptide|length=494bp
MWCYCTRSQHHICNESIGKIKCANGTKHCVIGLSEKGKTQSCWEWPNTSD
CPDEAGPCYLLGHNTKQPACCCKGNLCNDISVKYSIKFPKVYTTINPQSL
VMIPNTGQVNIFWIYVVLLLAISLIASIVFIVVKRFAIHSKTSINSNRKI
FDVENINDNVRTPIAKLCENGSRYEENTVLINQISTENLYSLCDKNQLLA
QGRFGQVWSGIIETRNEHKKQIVAIKIFSDNKEGKKSWRNESTVYSILQN
GPHPNILKYFGAERRMKDSITELWLVVEYYPLGSLWNYLKKSTVTWSDLL
QICQNIAAGLAHLHSFSKPINSPIAHRDIKSKNILLKENYTACIADFGLA
ICHQNTDNSFNNRVGTLSYMAPEILEGSINFDIYSFLKIDIFSMSLVFWE
VLSRFQFSDLHIKDFQNPFQEIVGENPSFEQLRQCVTIKKLRPAFNENWI
NLPDVIKFWKTITECWDEDPDARLSAECVLERMNDLCNINSIE*

Annotated Terms

The following terms have been associated with this transcript:

Vocabulary: **Planarian Anatomy**
Term	Definition
PLANA:0000074	oocyte
PLANA:0000231	vitelline gland
PLANA:0002089	reproductive organ
PLANA:0003116	parenchymal cell

Vocabulary: **INTERPRO**
Term	Definition
IPR000299	FERM_domain
IPR000333	TGFB_receptor
IPR000719	Prot_kinase_dom
IPR008271	Ser/Thr_kinase_AS
IPR011009	Kinase-like_dom_sf

Vocabulary: **cellular component**
Term	Definition
GO:0005856	cytoskeleton
GO:0016020	membrane
GO:0016021	integral component of membrane

Vocabulary: **molecular function**
Term	Definition
GO:0005524	ATP binding
GO:0004702	signal transducer, downstream of receptor, with serine/threonine kinase activity
GO:0004672	protein kinase activity
GO:0000166	nucleotide binding
GO:0004674	protein serine/threonine kinase activity
GO:0004675	transmembrane receptor protein serine/threonine kinase activity
GO:0016301	kinase activity
GO:0016740	transferase activity
GO:0046872	metal ion binding

Vocabulary: **biological process**
Term	Definition
GO:0007178	transmembrane receptor protein serine/threonine kinase signaling pathway
GO:0006468	protein phosphorylation
GO:0016310	phosphorylation
GO:0023014	signal transduction by protein phosphorylation

InterPro

Analysis Name: Schmidtea mediteranean smed_20140614 Interproscan
Date Performed: 2020-05-01


IPR Term	IPR Description	Source	Source Term	Source Description	Alignment
IPR000333	Ser/Thr protein kinase, TGFB receptor	PRINTS	PR00653	ACTIVIN2R	coord: 58..81 score: 35.0 coord: 337..358 score: 46.67 coord: 454..473 score: 45.0
IPR000333	Ser/Thr protein kinase, TGFB receptor	PANTHER	PTHR23255	TRANSFORMING GROWTH FACTOR-BETA RECEPTOR TYPE I AND II	coord: 4..489
IPR000719	Protein kinase domain	SMART	SM00220	serkin_6	coord: 193..481 e-value: 1.6E-23 score: 94.1
IPR000719	Protein kinase domain	PFAM	PF00069	Pkinase	coord: 195..481 e-value: 4.4E-38 score: 131.2
IPR000719	Protein kinase domain	PROSITE	PS50011	PROTEIN_KINASE_DOM	coord: 193..486 score: 36.895
None	No IPR available	GENE3D	G3DSA:1.10.510.10		coord: 282..491 e-value: 4.0E-53 score: 182.1
None	No IPR available	GENE3D	G3DSA:3.30.200.20		coord: 186..281 e-value: 1.2E-20 score: 75.3
None	No IPR available	TMHMM	TMhelix		coord: 111..133
IPR008271	Serine/threonine-protein kinase, active site	PROSITE	PS00108	PROTEIN_KINASE_ST	coord: 324..336
IPR011009	Protein kinase-like domain superfamily	SUPERFAMILY	SSF56112	Protein kinase-like (PK-like)	coord: 194..482