Forkhead box protein

Overview
NameForkhead box protein
Smed IDSMED30012265
Length (bp)1407
Neoblast Clusters

Zeng et. al., 2018




▻ Overview

▻ Neoblast Population

▻ Sub-lethal Irradiated Surviving X1 and X2 Cell Population

 



 

Overview

 

Single cell RNA-seq of pluripotent neoblasts and its early progenies


We isolated X1 neoblasts cells enriched in high piwi-1 expression (Neoblast Population), and profiled ∼7,614 individual cells via scRNA-seq. Unsupervised analyses uncovered 12 distinct classes from 7,088 high-quality cells. We designated these classes Nb1 to Nb12 and ordered them based on high (Nb1) to low (Nb12) piwi-1 expression levels. We further defined groups of genes that best classified the cells parsed into 12 distinct cell clusters to generate a scaled expression heat map of discriminative gene sets for each cluster. Expression of each cluster’s gene signatures was validated using multiplex fluorescence in situ hybridization (FISH) co-stained with piwi-1 and largely confirmed the cell clusters revealed by scRNA-seq.

We also tested sub-lethal irradiation exposure. To profile rare pluripotent stem cells (PSCs) and avoid interference from immediate progenitor cells, we determined a time point after sub-lethal irradiation (7 DPI) with minimal piwi-1+ cells, followed by isolation and single-cell RNA-seq of 1,200 individual cells derived from X1 (Piwi-1 high) and X2 (Piwi-1 low) cell populations (Sub-lethal Irradiated Surviving X1 and X2 Cell Population)




Explore this single cell expression dataset with our NB Cluster Shiny App




 

Neoblast Population

 

t-SNE plot shows two-dimensional representation of global gene expression relationships among all neoblasts (n = 7,088 after filter). Cluster identity was assigned based on the top 10 marker genes of each cluster (Table S2), followed by inspection of RNA in situ hybridization patterns. Neoblast groups, Nb.


Expression of Forkhead box protein (SMED30012265) t-SNE clustered cells

Violin plots show distribution of expression levels for Forkhead box protein (SMED30012265) in cells (dots) of each of the 12 neoblast clusters.

 

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Sub-lethal Irradiated Surviving X1 and X2 Cell Population

 

t-SNE plot of surviving X1 and X2 cells (n = 1,039 after QC filter) after sub-lethal irradiation. Colors indicate unbiased cell classification via graph-based clustering. SL, sub-lethal irradiated cell groups.

Expression of Forkhead box protein (SMED30012265) in the t-SNE clustered sub-lethally irradiated X1 and X2 cells.

Violin plots show distribution of expression levels for Forkhead box protein (SMED30012265) in cells (dots) of each of the 10 clusters of sub-leathally irradiated X1 and X2 cells.

 

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Embryonic Expression

Davies et. al., 2017




Hover the mouse over a column in the graph to view average RPKM values per sample.
Sort Descending | Sort Ascending | Only Non-Zero Values | Tile/Chart | Reset

Embryonic Stages: Y: yolk. S2-S8: Stages 2-8. C4: asexual adult. SX: virgin, sexually mature adult.
For further information about sample preparation and analysis for the single animal RNA-Seq experiment, please refer to the Materials and Methods

 

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Anatomical Expression

PAGE et. al., 2020




SMED30012265

has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGE



PAGE Curations: 10

  
Expressed InReference TranscriptGene ModelsPublished TranscriptTranscriptomePublicationSpecimenLifecycleEvidence
neuronSMED30012265h1SMcG0002380 BK013025smed_ncbi_20240424PMID:33536473
Pascual-Carreras et al., 2021
whole organism asexual adult single-cell RNA-sequencing evidence
secretory cellSMED30012265h1SMcG0002380 BK013025smed_ncbi_20240424PMID:33536473
Pascual-Carreras et al., 2021
whole organism asexual adult single-cell RNA-sequencing evidence
whole organismSMED30012265h1SMcG0002380 BK013025smed_ncbi_20240424PMID:33536473
Pascual-Carreras et al., 2021
whole organism asexual adult colorimetric in situ hybridization evidence
epidermal cellSMED30012265h1SMcG0002380 BK013025smed_ncbi_20240424PMID:33536473
Pascual-Carreras et al., 2021
whole organism asexual adult single-cell RNA-sequencing evidence
parenchymal cellSMED30012265h1SMcG0002380 BK013025smed_ncbi_20240424PMID:33536473
Pascual-Carreras et al., 2021
whole organism asexual adult single-cell RNA-sequencing evidence
neoblastSMED30012265h1SMcG0002380 dd_Smed_v4_3040_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018
FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
parenchymal cellSMED30012265h1SMcG0002380 dd_Smed_v4_3040_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018
FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
posterior sideSMED30012265h1SMcG0002380 dd_Smed_v4_3040_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018
FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
posterior muscle cellSMED30012265h1SMcG0002380 dd_Smed_v4_3040_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018
FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
epidermisSMED30012265h1SMcG0002380 dd_Smed_v4_3040_0_1dd_Smed_v4PMID:28292427
Wurtzel et al., 2017
whole organism asexual adult single-cell RNA-sequencing evidence
Note: Hover over icons to view figure legend
Homology
BLAST of Forkhead box protein vs. Ensembl Human
Match: FOXO4 (forkhead box O4 [Source:HGNC Symbol;Acc:HGNC:7139])

HSP 1 Score: 108.997 bits (271), Expect = 5.463e-25
Identity = 77/189 (40.74%), Postives = 97/189 (51.32%), Query Frame = 1
Query:  136 LDDCHSPEFRARSQTWG------GNDNSYRSRIIEADLSQKYTTFASDSYTSFEESTVQENISPLKDSLPKIL-----PAKKSSRKNPWGQETYSDLIEAAINSHPNQMATLQQIYEFISKNNKYFAERVDATSSAGWKNSIRHNLSLHDKFVKCPKKNE-NMKSSLWSINTKCYK-----RERSNSMD 651
            LD    P+ R RS TW        N  S    + E DL +K  T    S      S + E   P     P IL     P K  SR+N WG ++Y++LI  AI S P +  TL QIYE++ +   YF ++ D+ SSAGWKNSIRHNLSLH KF+K    NE   KSS W +N +  K     R R+ SMD
Sbjct:   18 LDPDFEPQSRPRSCTWPLPRPEIANQPSEPPEV-EPDLGEKVHT-EGRSEPILLPSRLPE---PAGGPQPGILGAVTGPRKGGSRRNAWGNQSYAELISQAIESAPEKRLTLAQIYEWMVRTVPYFKDKGDSNSSAGWKNSIRHNLSLHSKFIKV--HNEATGKSSWWMLNPEGGKSGKAPRRRAASMD 199          
BLAST of Forkhead box protein vs. Ensembl Human
Match: FOXO3 (forkhead box O3 [Source:HGNC Symbol;Acc:HGNC:3821])

HSP 1 Score: 101.679 bits (252), Expect = 3.129e-22
Identity = 56/111 (50.45%), Postives = 72/111 (64.86%), Query Frame = 1
Query:  337 PAKKSSRKNPWGQETYSDLIEAAINSHPNQMATLQQIYEFISKNNKYFAERVDATSSAGWKNSIRHNLSLHDKFVKCPKKNENM-KSSLWSINTKCYK-----RERSNSMD 651
            P K SSR+N WG  +Y+DLI  AI S P++  TL QIYE++ +   YF ++ D+ SSAGWKNSIRHNLSLH +F++   +NE   KSS W IN    K     R R+ SMD
Sbjct:  147 PRKCSSRRNAWGNLSYADLITRAIESSPDKRLTLSQIYEWMVRCVPYFKDKGDSNSSAGWKNSIRHNLSLHSRFMRV--QNEGTGKSSWWIINPDGGKSGKAPRRRAVSMD 255          
BLAST of Forkhead box protein vs. Ensembl Human
Match: FOXO3 (forkhead box O3 [Source:HGNC Symbol;Acc:HGNC:3821])

HSP 1 Score: 101.679 bits (252), Expect = 3.129e-22
Identity = 56/111 (50.45%), Postives = 72/111 (64.86%), Query Frame = 1
Query:  337 PAKKSSRKNPWGQETYSDLIEAAINSHPNQMATLQQIYEFISKNNKYFAERVDATSSAGWKNSIRHNLSLHDKFVKCPKKNENM-KSSLWSINTKCYK-----RERSNSMD 651
            P K SSR+N WG  +Y+DLI  AI S P++  TL QIYE++ +   YF ++ D+ SSAGWKNSIRHNLSLH +F++   +NE   KSS W IN    K     R R+ SMD
Sbjct:  147 PRKCSSRRNAWGNLSYADLITRAIESSPDKRLTLSQIYEWMVRCVPYFKDKGDSNSSAGWKNSIRHNLSLHSRFMRV--QNEGTGKSSWWIINPDGGKSGKAPRRRAVSMD 255          
BLAST of Forkhead box protein vs. Ensembl Human
Match: FOXO6 (forkhead box O6 [Source:HGNC Symbol;Acc:HGNC:24814])

HSP 1 Score: 100.523 bits (249), Expect = 3.790e-22
Identity = 53/108 (49.07%), Postives = 72/108 (66.67%), Query Frame = 1
Query:  346 KSSRKNPWGQETYSDLIEAAINSHPNQMATLQQIYEFISKNNKYFAERVDATSSAGWKNSIRHNLSLHDKFVKCPKKNENM-KSSLWSINTKCYK-----RERSNSMD 651
            KSSR+N WG  +Y+DLI  AI S P++  TL QIY+++ +   YF ++ D+ SSAGWKNSIRHNLSLH +F++   +NE   KSS W +N +  K     R R+ SMD
Sbjct:   81 KSSRRNAWGNLSYADLITKAIESAPDKRLTLSQIYDWMVRYVPYFKDKGDSNSSAGWKNSIRHNLSLHTRFIRV--QNEGTGKSSWWMLNPEGGKTGKTPRRRAVSMD 186          
BLAST of Forkhead box protein vs. Ensembl Human
Match: FOXO6 (forkhead box O6 [Source:HGNC Symbol;Acc:HGNC:24814])

HSP 1 Score: 100.523 bits (249), Expect = 3.932e-22
Identity = 53/108 (49.07%), Postives = 72/108 (66.67%), Query Frame = 1
Query:  346 KSSRKNPWGQETYSDLIEAAINSHPNQMATLQQIYEFISKNNKYFAERVDATSSAGWKNSIRHNLSLHDKFVKCPKKNENM-KSSLWSINTKCYK-----RERSNSMD 651
            KSSR+N WG  +Y+DLI  AI S P++  TL QIY+++ +   YF ++ D+ SSAGWKNSIRHNLSLH +F++   +NE   KSS W +N +  K     R R+ SMD
Sbjct:   81 KSSRRNAWGNLSYADLITKAIESAPDKRLTLSQIYDWMVRYVPYFKDKGDSNSSAGWKNSIRHNLSLHTRFIRV--QNEGTGKSSWWMLNPEGGKTGKTPRRRAVSMD 186          
BLAST of Forkhead box protein vs. Ensembl Celegans
Match: daf-16 (Forkhead box protein O [Source:UniProtKB/Swiss-Prot;Acc:O16850])

HSP 1 Score: 97.8265 bits (242), Expect = 7.117e-22
Identity = 50/112 (44.64%), Postives = 72/112 (64.29%), Query Frame = 1
Query:  343 KKSSRKNPWGQETYSDLIEAAINSHPNQMATLQQIYEFISKNNKYFAERVDATSSAGWKNSIRHNLSLHDKFVKCPKKNENM-KSSLWSINTKCYK-------RERSNSMDC 654
            K ++R+N WG  +Y++LI  AI + P +  TL Q+YE++ +N  YF ++ D+ SSAGWKNSIRHNLSLH +F++   +NE   KSS W IN            RERSN+++ 
Sbjct:   31 KTTTRRNAWGNMSYAELITTAIMASPEKRLTLAQVYEWMVQNVPYFRDKGDSNSSAGWKNSIRHNLSLHSRFMRI--QNEGAGKSSWWVINPDAKPGRNPRRTRERSNTIET 140          
BLAST of Forkhead box protein vs. Ensembl Celegans
Match: daf-16 (Forkhead box protein O [Source:UniProtKB/Swiss-Prot;Acc:O16850])

HSP 1 Score: 97.4413 bits (241), Expect = 7.389e-22
Identity = 50/112 (44.64%), Postives = 72/112 (64.29%), Query Frame = 1
Query:  343 KKSSRKNPWGQETYSDLIEAAINSHPNQMATLQQIYEFISKNNKYFAERVDATSSAGWKNSIRHNLSLHDKFVKCPKKNENM-KSSLWSINTKCYK-------RERSNSMDC 654
            K ++R+N WG  +Y++LI  AI + P +  TL Q+YE++ +N  YF ++ D+ SSAGWKNSIRHNLSLH +F++   +NE   KSS W IN            RERSN+++ 
Sbjct:   33 KTTTRRNAWGNMSYAELITTAIMASPEKRLTLAQVYEWMVQNVPYFRDKGDSNSSAGWKNSIRHNLSLHSRFMRI--QNEGAGKSSWWVINPDAKPGRNPRRTRERSNTIET 142          
BLAST of Forkhead box protein vs. Ensembl Celegans
Match: daf-16 (Forkhead box protein O [Source:UniProtKB/Swiss-Prot;Acc:O16850])

HSP 1 Score: 97.4413 bits (241), Expect = 1.416e-21
Identity = 50/112 (44.64%), Postives = 72/112 (64.29%), Query Frame = 1
Query:  343 KKSSRKNPWGQETYSDLIEAAINSHPNQMATLQQIYEFISKNNKYFAERVDATSSAGWKNSIRHNLSLHDKFVKCPKKNENM-KSSLWSINTKCYK-------RERSNSMDC 654
            K ++R+N WG  +Y++LI  AI + P +  TL Q+YE++ +N  YF ++ D+ SSAGWKNSIRHNLSLH +F++   +NE   KSS W IN            RERSN+++ 
Sbjct:  113 KTTTRRNAWGNMSYAELITTAIMASPEKRLTLAQVYEWMVQNVPYFRDKGDSNSSAGWKNSIRHNLSLHSRFMRI--QNEGAGKSSWWVINPDAKPGRNPRRTRERSNTIET 222          
BLAST of Forkhead box protein vs. Ensembl Celegans
Match: daf-16 (Forkhead box protein O [Source:UniProtKB/Swiss-Prot;Acc:O16850])

HSP 1 Score: 97.4413 bits (241), Expect = 1.485e-21
Identity = 50/112 (44.64%), Postives = 72/112 (64.29%), Query Frame = 1
Query:  343 KKSSRKNPWGQETYSDLIEAAINSHPNQMATLQQIYEFISKNNKYFAERVDATSSAGWKNSIRHNLSLHDKFVKCPKKNENM-KSSLWSINTKCYK-------RERSNSMDC 654
            K ++R+N WG  +Y++LI  AI + P +  TL Q+YE++ +N  YF ++ D+ SSAGWKNSIRHNLSLH +F++   +NE   KSS W IN            RERSN+++ 
Sbjct:  136 KTTTRRNAWGNMSYAELITTAIMASPEKRLTLAQVYEWMVQNVPYFRDKGDSNSSAGWKNSIRHNLSLHSRFMRI--QNEGAGKSSWWVINPDAKPGRNPRRTRERSNTIET 245          
BLAST of Forkhead box protein vs. Ensembl Celegans
Match: daf-16 (Forkhead box protein O [Source:UniProtKB/Swiss-Prot;Acc:O16850])

HSP 1 Score: 97.4413 bits (241), Expect = 1.485e-21
Identity = 50/112 (44.64%), Postives = 72/112 (64.29%), Query Frame = 1
Query:  343 KKSSRKNPWGQETYSDLIEAAINSHPNQMATLQQIYEFISKNNKYFAERVDATSSAGWKNSIRHNLSLHDKFVKCPKKNENM-KSSLWSINTKCYK-------RERSNSMDC 654
            K ++R+N WG  +Y++LI  AI + P +  TL Q+YE++ +N  YF ++ D+ SSAGWKNSIRHNLSLH +F++   +NE   KSS W IN            RERSN+++ 
Sbjct:  136 KTTTRRNAWGNMSYAELITTAIMASPEKRLTLAQVYEWMVQNVPYFRDKGDSNSSAGWKNSIRHNLSLHSRFMRI--QNEGAGKSSWWVINPDAKPGRNPRRTRERSNTIET 245          
BLAST of Forkhead box protein vs. Ensembl Fly
Match: foxo (gene:FBgn0038197 transcript:FBtr0082887)

HSP 1 Score: 99.7525 bits (247), Expect = 5.868e-22
Identity = 69/192 (35.94%), Postives = 98/192 (51.04%), Query Frame = 1
Query:  115 SLAMNNM-----LDDCHSPEFRARSQTWGGNDNSYRSRIIEADLSQKYTTFASDSYTSFEESTVQENISPLKDSLPKILPAKKSSRKNPWGQETYSDLIEAAINSHPNQMATLQQIYEFISKNNKYFAERVDATSSAGWKNSIRHNLSLHDKFVKCPKKNENM-KSSLWSINTKCYK----RERSNSMDCKR 660
             LAM+ +     LD    P+ RARS TW           +E       T  ++      +     +N +  K         K SSR+N WG  +Y+DLI  AI S  ++  TL QIYE++ +N  YF ++ D+ SSAGWKNSIRHNLSLH++F++   +NE   KSS W +N +       R R+ SM+  R
Sbjct:   18 GLAMDQLGGDLPLDVGFEPQTRARSNTW---PCPRPENFVEPTDELDSTKASNQQLAPGDSQQAIQNANAAK---------KNSSRRNAWGNLSYADLITHAIGSATDKRLTLSQIYEWMVQNVPYFKDKGDSNSSAGWKNSIRHNLSLHNRFMRV--QNEGTGKSSWWMLNPEAKPGKSVRRRAASMETSR 195          
BLAST of Forkhead box protein vs. Ensembl Fly
Match: foxo (gene:FBgn0038197 transcript:FBtr0082886)

HSP 1 Score: 99.7525 bits (247), Expect = 5.868e-22
Identity = 69/192 (35.94%), Postives = 98/192 (51.04%), Query Frame = 1
Query:  115 SLAMNNM-----LDDCHSPEFRARSQTWGGNDNSYRSRIIEADLSQKYTTFASDSYTSFEESTVQENISPLKDSLPKILPAKKSSRKNPWGQETYSDLIEAAINSHPNQMATLQQIYEFISKNNKYFAERVDATSSAGWKNSIRHNLSLHDKFVKCPKKNENM-KSSLWSINTKCYK----RERSNSMDCKR 660
             LAM+ +     LD    P+ RARS TW           +E       T  ++      +     +N +  K         K SSR+N WG  +Y+DLI  AI S  ++  TL QIYE++ +N  YF ++ D+ SSAGWKNSIRHNLSLH++F++   +NE   KSS W +N +       R R+ SM+  R
Sbjct:   18 GLAMDQLGGDLPLDVGFEPQTRARSNTW---PCPRPENFVEPTDELDSTKASNQQLAPGDSQQAIQNANAAK---------KNSSRRNAWGNLSYADLITHAIGSATDKRLTLSQIYEWMVQNVPYFKDKGDSNSSAGWKNSIRHNLSLHNRFMRV--QNEGTGKSSWWMLNPEAKPGKSVRRRAASMETSR 195          
BLAST of Forkhead box protein vs. Ensembl Fly
Match: foxo (gene:FBgn0038197 transcript:FBtr0346723)

HSP 1 Score: 99.3673 bits (246), Expect = 7.121e-22
Identity = 69/192 (35.94%), Postives = 98/192 (51.04%), Query Frame = 1
Query:  115 SLAMNNM-----LDDCHSPEFRARSQTWGGNDNSYRSRIIEADLSQKYTTFASDSYTSFEESTVQENISPLKDSLPKILPAKKSSRKNPWGQETYSDLIEAAINSHPNQMATLQQIYEFISKNNKYFAERVDATSSAGWKNSIRHNLSLHDKFVKCPKKNENM-KSSLWSINTKCYK----RERSNSMDCKR 660
             LAM+ +     LD    P+ RARS TW           +E       T  ++      +     +N +  K         K SSR+N WG  +Y+DLI  AI S  ++  TL QIYE++ +N  YF ++ D+ SSAGWKNSIRHNLSLH++F++   +NE   KSS W +N +       R R+ SM+  R
Sbjct:   18 GLAMDQLGGDLPLDVGFEPQTRARSNTW---PCPRPENFVEPTDELDSTKASNQQLAPGDSQQAIQNANAAK---------KNSSRRNAWGNLSYADLITHAIGSATDKRLTLSQIYEWMVQNVPYFKDKGDSNSSAGWKNSIRHNLSLHNRFMRV--QNEGTGKSSWWMLNPEAKPGKSVRRRAASMETSR 195          
BLAST of Forkhead box protein vs. Ensembl Fly
Match: foxo (gene:FBgn0038197 transcript:FBtr0337094)

HSP 1 Score: 98.9821 bits (245), Expect = 8.206e-22
Identity = 69/192 (35.94%), Postives = 98/192 (51.04%), Query Frame = 1
Query:  115 SLAMNNM-----LDDCHSPEFRARSQTWGGNDNSYRSRIIEADLSQKYTTFASDSYTSFEESTVQENISPLKDSLPKILPAKKSSRKNPWGQETYSDLIEAAINSHPNQMATLQQIYEFISKNNKYFAERVDATSSAGWKNSIRHNLSLHDKFVKCPKKNENM-KSSLWSINTKCYK----RERSNSMDCKR 660
             LAM+ +     LD    P+ RARS TW           +E       T  ++      +     +N +  K         K SSR+N WG  +Y+DLI  AI S  ++  TL QIYE++ +N  YF ++ D+ SSAGWKNSIRHNLSLH++F++   +NE   KSS W +N +       R R+ SM+  R
Sbjct:   18 GLAMDQLGGDLPLDVGFEPQTRARSNTW---PCPRPENFVEPTDELDSTKASNQQLAPGDSQQAIQNANAAK---------KNSSRRNAWGNLSYADLITHAIGSATDKRLTLSQIYEWMVQNVPYFKDKGDSNSSAGWKNSIRHNLSLHNRFMRV--QNEGTGKSSWWMLNPEAKPGKSVRRRAASMETSR 195          
BLAST of Forkhead box protein vs. Ensembl Fly
Match: foxo (gene:FBgn0038197 transcript:FBtr0305052)

HSP 1 Score: 98.9821 bits (245), Expect = 8.206e-22
Identity = 69/192 (35.94%), Postives = 98/192 (51.04%), Query Frame = 1
Query:  115 SLAMNNM-----LDDCHSPEFRARSQTWGGNDNSYRSRIIEADLSQKYTTFASDSYTSFEESTVQENISPLKDSLPKILPAKKSSRKNPWGQETYSDLIEAAINSHPNQMATLQQIYEFISKNNKYFAERVDATSSAGWKNSIRHNLSLHDKFVKCPKKNENM-KSSLWSINTKCYK----RERSNSMDCKR 660
             LAM+ +     LD    P+ RARS TW           +E       T  ++      +     +N +  K         K SSR+N WG  +Y+DLI  AI S  ++  TL QIYE++ +N  YF ++ D+ SSAGWKNSIRHNLSLH++F++   +NE   KSS W +N +       R R+ SM+  R
Sbjct:   18 GLAMDQLGGDLPLDVGFEPQTRARSNTW---PCPRPENFVEPTDELDSTKASNQQLAPGDSQQAIQNANAAK---------KNSSRRNAWGNLSYADLITHAIGSATDKRLTLSQIYEWMVQNVPYFKDKGDSNSSAGWKNSIRHNLSLHNRFMRV--QNEGTGKSSWWMLNPEAKPGKSVRRRAASMETSR 195          
BLAST of Forkhead box protein vs. Ensembl Zebrafish
Match: foxo4 (forkhead box O4 [Source:ZFIN;Acc:ZDB-GENE-150311-1])

HSP 1 Score: 104.375 bits (259), Expect = 2.051e-23
Identity = 62/131 (47.33%), Postives = 82/131 (62.60%), Query Frame = 1
Query:  337 PAKKSSRKNPWGQETYSDLIEAAINSHPNQMATLQQIYEFISKNNKYFAERVDATSSAGWKNSIRHNLSLHDKFVKCPKKNENM-KSSLWSINTKCYK-----RERSNSMDCKRSGVDLIARRKLLKEQRR 711
            P K SSR+N WG ++Y+DLI  AI + P +  TL QIY+++ K   YF ++ D+ SSAGWKNSIRHNLSLH+KF++    NE+  KSS W +N +  K     R R+ SMD   SG       KLLK + R
Sbjct:   84 PRKGSSRRNAWGNQSYADLISQAIENSPEKRLTLAQIYDWMVKTVPYFKDKGDSNSSAGWKNSIRHNLSLHNKFLRV--HNESTGKSSWWMLNPEGGKTGKAHRRRATSMD--NSG-------KLLKSRIR 203          
BLAST of Forkhead box protein vs. Ensembl Zebrafish
Match: foxo4 (forkhead box O4 [Source:ZFIN;Acc:ZDB-GENE-150311-1])

HSP 1 Score: 104.375 bits (259), Expect = 2.051e-23
Identity = 62/131 (47.33%), Postives = 82/131 (62.60%), Query Frame = 1
Query:  337 PAKKSSRKNPWGQETYSDLIEAAINSHPNQMATLQQIYEFISKNNKYFAERVDATSSAGWKNSIRHNLSLHDKFVKCPKKNENM-KSSLWSINTKCYK-----RERSNSMDCKRSGVDLIARRKLLKEQRR 711
            P K SSR+N WG ++Y+DLI  AI + P +  TL QIY+++ K   YF ++ D+ SSAGWKNSIRHNLSLH+KF++    NE+  KSS W +N +  K     R R+ SMD   SG       KLLK + R
Sbjct:   84 PRKGSSRRNAWGNQSYADLISQAIENSPEKRLTLAQIYDWMVKTVPYFKDKGDSNSSAGWKNSIRHNLSLHNKFLRV--HNESTGKSSWWMLNPEGGKTGKAHRRRATSMD--NSG-------KLLKSRIR 203          
BLAST of Forkhead box protein vs. Ensembl Zebrafish
Match: foxo3a (forkhead box O3A [Source:ZFIN;Acc:ZDB-GENE-050116-1])

HSP 1 Score: 103.99 bits (258), Expect = 2.817e-23
Identity = 56/125 (44.80%), Postives = 77/125 (61.60%), Query Frame = 1
Query:  337 PAKKSSRKNPWGQETYSDLIEAAINSHPNQMATLQQIYEFISKNNKYFAERVDATSSAGWKNSIRHNLSLHDKFVKCPKKNENM-KSSLWSINTKCYKRERSNSMDCKRSGVDLIARRKLLKEQR 708
            P K S+R+N WG  +Y+DLI  AI S P +  TL QIY+++ +N  YF ++ D+ SSAGWKNSIRHNLSLH +FV+   +NE   KSS W +N    K  ++     +R  V +    KL+K  R
Sbjct:  130 PRKSSARRNAWGNYSYADLITQAIESSPEKRLTLAQIYDWMVRNVPYFKDKGDSNSSAGWKNSIRHNLSLHSRFVRV--QNEGTGKSSWWMVNPDGGKGGKA----PRRRAVSMDNSNKLIKSAR 248          
BLAST of Forkhead box protein vs. Ensembl Zebrafish
Match: foxo1b (forkhead box O1 b [Source:NCBI gene;Acc:567969])

HSP 1 Score: 103.219 bits (256), Expect = 5.661e-23
Identity = 55/107 (51.40%), Postives = 71/107 (66.36%), Query Frame = 1
Query:  349 SSRKNPWGQETYSDLIEAAINSHPNQMATLQQIYEFISKNNKYFAERVDATSSAGWKNSIRHNLSLHDKFVKCPKKNENM-KSSLWSINTKCYK-----RERSNSMD 651
            SSR+N WG  +Y+DLI  AI S P +  TL QIYE++ K+  YF ++ D+ SSAGWKNSIRHNLSLH +FV+   +NE   KSS W +N +  K     R R+ SMD
Sbjct:  130 SSRRNAWGNMSYADLITKAIESSPEKRLTLSQIYEWMVKSVPYFKDKGDSNSSAGWKNSIRHNLSLHSRFVRV--QNEGTGKSSWWMLNPEGGKSGKSPRRRATSMD 234          
BLAST of Forkhead box protein vs. Ensembl Zebrafish
Match: foxo6a (forkhead box O6 a [Source:ZFIN;Acc:ZDB-GENE-110914-126])

HSP 1 Score: 102.834 bits (255), Expect = 7.155e-23
Identity = 66/173 (38.15%), Postives = 96/173 (55.49%), Query Frame = 1
Query:  166 ARSQTWGGNDNSYRSRIIEADLSQKYTTFASDSYTSFEESTVQENISPLKDSLPKILPA-----KKSSRKNPWGQETYSDLIEAAINSHPNQMATLQQIYEFISKNNKYFAERVDATSSAGWKNSIRHNLSLHDKFVKCPKKNENM-KSSLWSINTKCYK-----RERSNSMD 651
            ARS +W    N +   ++ ADLS   + F  DS  +   S  +  +         +  A     K SSR+N WG ++Y++LI  AI S P++  TL QIY+++ +   YF ++ D+ SSAGWKNSIRHNLSLH +F++   +NE   KSS W +N +  K     R R+ SMD
Sbjct:   23 ARSCSW---TNDFSCDVVNADLSLNLSIFQVDSDRAPSPSCRRRMMVLDAGGFHDLTGAALRKTKASSRRNAWGNQSYAELITRAIESTPDKRLTLSQIYDWMVRYVPYFKDKGDSNSSAGWKNSIRHNLSLHTRFIRV--QNEGTGKSSWWMLNPEGGKLGKSQRRRAVSMD 190          
BLAST of Forkhead box protein vs. Ensembl Xenopus
Match: FOXO4 (forkhead box O4 [Source:NCBI gene;Acc:100492831])

HSP 1 Score: 103.219 bits (256), Expect = 4.521e-23
Identity = 55/111 (49.55%), Postives = 72/111 (64.86%), Query Frame = 1
Query:  337 PAKKSSRKNPWGQETYSDLIEAAINSHPNQMATLQQIYEFISKNNKYFAERVDATSSAGWKNSIRHNLSLHDKFVKCPKKNE-NMKSSLWSINTKCYK-----RERSNSMD 651
            P K  SR+N WG ++Y++LI  AI S P +  TL QIY+++ K+  YF ++ D+ SSAGWKNSIRHNLSLH KF+K    NE   KSS W +N +  K     R R+ SMD
Sbjct:   77 PRKGGSRRNAWGNQSYAELISQAIESSPEKRLTLSQIYDWMVKSIPYFKDKGDSNSSAGWKNSIRHNLSLHSKFIKV--HNEATGKSSWWMLNPEGGKSGKAPRRRAASMD 185          
BLAST of Forkhead box protein vs. Ensembl Xenopus
Match: FOXO4 (forkhead box O4 [Source:NCBI gene;Acc:100492831])

HSP 1 Score: 103.219 bits (256), Expect = 4.883e-23
Identity = 55/111 (49.55%), Postives = 72/111 (64.86%), Query Frame = 1
Query:  337 PAKKSSRKNPWGQETYSDLIEAAINSHPNQMATLQQIYEFISKNNKYFAERVDATSSAGWKNSIRHNLSLHDKFVKCPKKNE-NMKSSLWSINTKCYK-----RERSNSMD 651
            P K  SR+N WG ++Y++LI  AI S P +  TL QIY+++ K+  YF ++ D+ SSAGWKNSIRHNLSLH KF+K    NE   KSS W +N +  K     R R+ SMD
Sbjct:   77 PRKGGSRRNAWGNQSYAELISQAIESSPEKRLTLSQIYDWMVKSIPYFKDKGDSNSSAGWKNSIRHNLSLHSKFIKV--HNEATGKSSWWMLNPEGGKSGKAPRRRAASMD 185          
BLAST of Forkhead box protein vs. Ensembl Xenopus
Match: foxo1 (forkhead box O1 [Source:NCBI gene;Acc:493378])

HSP 1 Score: 101.679 bits (252), Expect = 2.469e-22
Identity = 55/107 (51.40%), Postives = 71/107 (66.36%), Query Frame = 1
Query:  349 SSRKNPWGQETYSDLIEAAINSHPNQMATLQQIYEFISKNNKYFAERVDATSSAGWKNSIRHNLSLHDKFVKCPKKNENM-KSSLWSINTKCYK-----RERSNSMD 651
            SSR+N WG  +Y+DLI  AI S P +  TL QIY+++ K+  YF ++ D+ SSAGWKNSIRHNLSLH KFV+   +NE   KSS W +N +  K     R R+ SMD
Sbjct:  138 SSRRNAWGNLSYADLISQAIESSPEKRLTLSQIYDWMVKSVPYFKDKGDSNSSAGWKNSIRHNLSLHSKFVRV--QNEGTGKSSWWILNPEGGKNGKSPRRRAASMD 242          
BLAST of Forkhead box protein vs. Ensembl Xenopus
Match: c2cd4c (C2 calcium-dependent domain containing 4C [Source:Xenbase;Acc:XB-GENE-5998006])

HSP 1 Score: 98.5969 bits (244), Expect = 1.706e-21
Identity = 53/108 (49.07%), Postives = 71/108 (65.74%), Query Frame = 1
Query:  346 KSSRKNPWGQETYSDLIEAAINSHPNQMATLQQIYEFISKNNKYFAERVDATSSAGWKNSIRHNLSLHDKFVKCPKKNENM-KSSLWSINTKCYK-----RERSNSMD 651
            KSSR+N WG  +Y+DLI  AI S P +  TL QIY+++ +   YF ++ D+ SSAGWKNSIRHNLSLH +F++   +NE   KSS W +N +  K     R R+ SMD
Sbjct:   48 KSSRRNAWGNLSYADLITKAIESSPERRLTLSQIYDWMVRFVPYFKDKGDSNSSAGWKNSIRHNLSLHTRFIRV--QNEGTGKSSWWMLNPEGGKTGKTPRRRAASMD 153          
BLAST of Forkhead box protein vs. Ensembl Xenopus
Match: foxo3 (forkhead box O3 [Source:NCBI gene;Acc:100125025])

HSP 1 Score: 97.0561 bits (240), Expect = 8.635e-21
Identity = 53/109 (48.62%), Postives = 72/109 (66.06%), Query Frame = 1
Query:  343 KKSSRKNPWGQETYSDLIEAAINSHPNQMATLQQIYEFISKNNKYFAERVDATSSAGWKNSIRHNLSLHDKFVKCPKKNEN-MKSSLWSINTKCYK-----RERSNSMD 651
            K SSR+N WG  +Y+DLI  AI S  ++  TL QIY+++ ++  YF ++ D+ SSAGWKNSIRHNLSLH +F++   +NE   KSS W IN +  K     R R+ SMD
Sbjct:  130 KCSSRRNAWGNMSYADLITRAIESSQDKRLTLSQIYDWMVRSVPYFKDKGDSNSSAGWKNSIRHNLSLHSRFIRV--QNEGSGKSSWWMINPEGGKGGKAPRRRAVSMD 236          
BLAST of Forkhead box protein vs. Ensembl Mouse
Match: Foxo4 (forkhead box O4 [Source:MGI Symbol;Acc:MGI:1891915])

HSP 1 Score: 107.842 bits (268), Expect = 9.542e-25
Identity = 75/188 (39.89%), Postives = 94/188 (50.00%), Query Frame = 1
Query:  136 LDDCHSPEFRARSQTWGGN-----DNSYRSRIIEADLSQKYTTFASDSYTSFEESTVQENISPLKDSLPKIL-----PAKKSSRKNPWGQETYSDLIEAAINSHPNQMATLQQIYEFISKNNKYFAERVDATSSAGWKNSIRHNLSLHDKFVKCPKKNE-NMKSSLWSINTKCYK-----RERSNSMD 651
            LD    P+ R RS TW           +    +E  L QK  T    S      S + E   P     P IL     P K  SR+N WG ++Y++LI  AI S P +  TL QIYE++ +   YF ++ D+ SSAGWKNSIRHNLSLH KF+K    NE   KSS W +N    K     R R+ SMD
Sbjct:   18 LDPDFEPQSRPRSCTWPLPRPDLATEPHEPSEVEPSLGQKVPT-EGHSEPILLPSRLPE---PAGGPQPGILGAVTGPRKGGSRRNAWGNQSYAELISQAIESAPEKRLTLAQIYEWMVRTVPYFKDKGDSNSSAGWKNSIRHNLSLHSKFIKV--HNEATGKSSWWMLNPDGGKGGKAPRRRAASMD 199          
BLAST of Forkhead box protein vs. Ensembl Mouse
Match: Foxo3 (forkhead box O3 [Source:MGI Symbol;Acc:MGI:1890081])

HSP 1 Score: 101.679 bits (252), Expect = 1.977e-22
Identity = 56/111 (50.45%), Postives = 72/111 (64.86%), Query Frame = 1
Query:  337 PAKKSSRKNPWGQETYSDLIEAAINSHPNQMATLQQIYEFISKNNKYFAERVDATSSAGWKNSIRHNLSLHDKFVKCPKKNENM-KSSLWSINTKCYK-----RERSNSMD 651
            P K SSR+N WG  +Y+DLI  AI S P++  TL QIYE++ +   YF ++ D+ SSAGWKNSIRHNLSLH +F++   +NE   KSS W IN    K     R R+ SMD
Sbjct:  146 PRKCSSRRNAWGNLSYADLITRAIESSPDKRLTLSQIYEWMVRCVPYFKDKGDSNSSAGWKNSIRHNLSLHSRFMRV--QNEGTGKSSWWIINPDGGKSGKAPRRRAVSMD 254          
BLAST of Forkhead box protein vs. Ensembl Mouse
Match: Foxo3 (forkhead box O3 [Source:MGI Symbol;Acc:MGI:1890081])

HSP 1 Score: 101.679 bits (252), Expect = 1.977e-22
Identity = 56/111 (50.45%), Postives = 72/111 (64.86%), Query Frame = 1
Query:  337 PAKKSSRKNPWGQETYSDLIEAAINSHPNQMATLQQIYEFISKNNKYFAERVDATSSAGWKNSIRHNLSLHDKFVKCPKKNENM-KSSLWSINTKCYK-----RERSNSMD 651
            P K SSR+N WG  +Y+DLI  AI S P++  TL QIYE++ +   YF ++ D+ SSAGWKNSIRHNLSLH +F++   +NE   KSS W IN    K     R R+ SMD
Sbjct:  146 PRKCSSRRNAWGNLSYADLITRAIESSPDKRLTLSQIYEWMVRCVPYFKDKGDSNSSAGWKNSIRHNLSLHSRFMRV--QNEGTGKSSWWIINPDGGKSGKAPRRRAVSMD 254          
BLAST of Forkhead box protein vs. Ensembl Mouse
Match: Foxo3 (forkhead box O3 [Source:MGI Symbol;Acc:MGI:1890081])

HSP 1 Score: 101.679 bits (252), Expect = 1.977e-22
Identity = 56/111 (50.45%), Postives = 72/111 (64.86%), Query Frame = 1
Query:  337 PAKKSSRKNPWGQETYSDLIEAAINSHPNQMATLQQIYEFISKNNKYFAERVDATSSAGWKNSIRHNLSLHDKFVKCPKKNENM-KSSLWSINTKCYK-----RERSNSMD 651
            P K SSR+N WG  +Y+DLI  AI S P++  TL QIYE++ +   YF ++ D+ SSAGWKNSIRHNLSLH +F++   +NE   KSS W IN    K     R R+ SMD
Sbjct:  146 PRKCSSRRNAWGNLSYADLITRAIESSPDKRLTLSQIYEWMVRCVPYFKDKGDSNSSAGWKNSIRHNLSLHSRFMRV--QNEGTGKSSWWIINPDGGKSGKAPRRRAVSMD 254          
BLAST of Forkhead box protein vs. Ensembl Mouse
Match: Foxo6 (forkhead box O6 [Source:MGI Symbol;Acc:MGI:2676586])

HSP 1 Score: 100.523 bits (249), Expect = 3.125e-22
Identity = 53/108 (49.07%), Postives = 72/108 (66.67%), Query Frame = 1
Query:  346 KSSRKNPWGQETYSDLIEAAINSHPNQMATLQQIYEFISKNNKYFAERVDATSSAGWKNSIRHNLSLHDKFVKCPKKNENM-KSSLWSINTKCYK-----RERSNSMD 651
            KSSR+N WG  +Y+DLI  AI S P++  TL QIY+++ +   YF ++ D+ SSAGWKNSIRHNLSLH +F++   +NE   KSS W +N +  K     R R+ SMD
Sbjct:   81 KSSRRNAWGNLSYADLITKAIESAPDKRLTLSQIYDWMVRYVPYFKDKGDSNSSAGWKNSIRHNLSLHTRFIRV--QNEGTGKSSWWMLNPEGGKTGKTPRRRAVSMD 186          
BLAST of Forkhead box protein vs. UniProt/SwissProt
Match: sp|P98177|FOXO4_HUMAN (Forkhead box protein O4 OS=Homo sapiens OX=9606 GN=FOXO4 PE=1 SV=5)

HSP 1 Score: 108.997 bits (271), Expect = 2.624e-24
Identity = 77/189 (40.74%), Postives = 97/189 (51.32%), Query Frame = 1
Query:  136 LDDCHSPEFRARSQTWG------GNDNSYRSRIIEADLSQKYTTFASDSYTSFEESTVQENISPLKDSLPKIL-----PAKKSSRKNPWGQETYSDLIEAAINSHPNQMATLQQIYEFISKNNKYFAERVDATSSAGWKNSIRHNLSLHDKFVKCPKKNE-NMKSSLWSINTKCYK-----RERSNSMD 651
            LD    P+ R RS TW        N  S    + E DL +K  T    S      S + E   P     P IL     P K  SR+N WG ++Y++LI  AI S P +  TL QIYE++ +   YF ++ D+ SSAGWKNSIRHNLSLH KF+K    NE   KSS W +N +  K     R R+ SMD
Sbjct:   18 LDPDFEPQSRPRSCTWPLPRPEIANQPSEPPEV-EPDLGEKVHT-EGRSEPILLPSRLPE---PAGGPQPGILGAVTGPRKGGSRRNAWGNQSYAELISQAIESAPEKRLTLAQIYEWMVRTVPYFKDKGDSNSSAGWKNSIRHNLSLHSKFIKV--HNEATGKSSWWMLNPEGGKSGKAPRRRAASMD 199          
BLAST of Forkhead box protein vs. UniProt/SwissProt
Match: sp|Q9WVH3|FOXO4_MOUSE (Forkhead box protein O4 OS=Mus musculus OX=10090 GN=Foxo4 PE=1 SV=1)

HSP 1 Score: 107.842 bits (268), Expect = 6.674e-24
Identity = 75/188 (39.89%), Postives = 94/188 (50.00%), Query Frame = 1
Query:  136 LDDCHSPEFRARSQTWGGN-----DNSYRSRIIEADLSQKYTTFASDSYTSFEESTVQENISPLKDSLPKIL-----PAKKSSRKNPWGQETYSDLIEAAINSHPNQMATLQQIYEFISKNNKYFAERVDATSSAGWKNSIRHNLSLHDKFVKCPKKNE-NMKSSLWSINTKCYK-----RERSNSMD 651
            LD    P+ R RS TW           +    +E  L QK  T    S      S + E   P     P IL     P K  SR+N WG ++Y++LI  AI S P +  TL QIYE++ +   YF ++ D+ SSAGWKNSIRHNLSLH KF+K    NE   KSS W +N    K     R R+ SMD
Sbjct:   18 LDPDFEPQSRPRSCTWPLPRPDLATEPHEPSEVEPSLGQKVPT-EGHSEPILLPSRLPE---PAGGPQPGILGAVTGPRKGGSRRNAWGNQSYAELISQAIESAPEKRLTLAQIYEWMVRTVPYFKDKGDSNSSAGWKNSIRHNLSLHSKFIKV--HNEATGKSSWWMLNPDGGKGGKAPRRRAASMD 199          
BLAST of Forkhead box protein vs. UniProt/SwissProt
Match: sp|A3RK75|FX1AB_DANRE (Forkhead box protein O1-B OS=Danio rerio OX=7955 GN=foxo1b PE=2 SV=1)

HSP 1 Score: 103.219 bits (256), Expect = 4.273e-22
Identity = 55/107 (51.40%), Postives = 71/107 (66.36%), Query Frame = 1
Query:  349 SSRKNPWGQETYSDLIEAAINSHPNQMATLQQIYEFISKNNKYFAERVDATSSAGWKNSIRHNLSLHDKFVKCPKKNENM-KSSLWSINTKCYK-----RERSNSMD 651
            SSR+N WG  +Y+DLI  AI S P +  TL QIYE++ K+  YF ++ D+ SSAGWKNSIRHNLSLH +FV+   +NE   KSS W +N +  K     R R+ SMD
Sbjct:  130 SSRRNAWGNMSYADLITKAIESSPEKRLTLSQIYEWMVKSVPYFKDKGDSNSSAGWKNSIRHNLSLHSRFVRV--QNEGTGKSSWWMLNPEGGKSGKSPRRRATSMD 234          
BLAST of Forkhead box protein vs. UniProt/SwissProt
Match: sp|Q66JJ0|FOXO1_XENTR (Forkhead box protein O1 OS=Xenopus tropicalis OX=8364 GN=foxo1 PE=2 SV=1)

HSP 1 Score: 101.679 bits (252), Expect = 1.308e-21
Identity = 55/107 (51.40%), Postives = 71/107 (66.36%), Query Frame = 1
Query:  349 SSRKNPWGQETYSDLIEAAINSHPNQMATLQQIYEFISKNNKYFAERVDATSSAGWKNSIRHNLSLHDKFVKCPKKNENM-KSSLWSINTKCYK-----RERSNSMD 651
            SSR+N WG  +Y+DLI  AI S P +  TL QIY+++ K+  YF ++ D+ SSAGWKNSIRHNLSLH KFV+   +NE   KSS W +N +  K     R R+ SMD
Sbjct:  138 SSRRNAWGNLSYADLISQAIESSPEKRLTLSQIYDWMVKSVPYFKDKGDSNSSAGWKNSIRHNLSLHSKFVRV--QNEGTGKSSWWILNPEGGKNGKSPRRRAASMD 242          
BLAST of Forkhead box protein vs. UniProt/SwissProt
Match: sp|Q6EUW2|FOXO1_XENLA (Forkhead box protein O1 OS=Xenopus laevis OX=8355 GN=foxo1 PE=2 SV=1)

HSP 1 Score: 101.679 bits (252), Expect = 1.358e-21
Identity = 55/107 (51.40%), Postives = 71/107 (66.36%), Query Frame = 1
Query:  349 SSRKNPWGQETYSDLIEAAINSHPNQMATLQQIYEFISKNNKYFAERVDATSSAGWKNSIRHNLSLHDKFVKCPKKNENM-KSSLWSINTKCYK-----RERSNSMD 651
            SSR+N WG  +Y+DLI  AI S P +  TL QIY+++ K+  YF ++ D+ SSAGWKNSIRHNLSLH KFV+   +NE   KSS W +N +  K     R R+ SMD
Sbjct:  143 SSRRNAWGNLSYADLISQAIESSPEKRLTLSQIYDWMVKSVPYFKDKGDSNSSAGWKNSIRHNLSLHSKFVRV--QNEGTGKSSWWILNPEGGKNGKSPRRRAASMD 247          
BLAST of Forkhead box protein vs. TrEMBL
Match: A0A4E0S0Z0 (Forkhead box protein O OS=Fasciola hepatica OX=6192 GN=D915_003164 PE=4 SV=1)

HSP 1 Score: 162.54 bits (410), Expect = 3.295e-39
Identity = 82/139 (58.99%), Postives = 95/139 (68.35%), Query Frame = 1
Query:  274 FEESTVQENISPLKDSLPK-ILPAKKSSRKNPWGQETYSDLIEAAINSHPNQMATLQQIYEFISKNNKYFAERVDATSSAGWKNSIRHNLSLHDKFVKCPKKNENMKSSLWSINT----KCYKRERSNSMDC---KRSG 666
               S    ++ P+    P    P KKSSR+NPWG ETYSDLI  AI+S+P+Q ATLQQIY+FI  N +YF ER D TSSAGWKNSIRHNLSLHD+F KCPK ++N KSS W INT    K Y R R+ SMD    KRSG
Sbjct:  217 VSSSAAATSVVPINTPAPSSTTPVKKSSRRNPWGSETYSDLISIAIHSYPDQQATLQQIYDFIISNYEYFRERSDPTSSAGWKNSIRHNLSLHDRFTKCPKSSDNTKSSYWRINTEVASKPYVRRRACSMDANNLKRSG 355          
BLAST of Forkhead box protein vs. TrEMBL
Match: A0A504YWL7 (Forkhead box protein O OS=Fasciola gigantica OX=46835 GN=FGIG_00041 PE=4 SV=1)

HSP 1 Score: 161.77 bits (408), Expect = 5.384e-39
Identity = 82/139 (58.99%), Postives = 95/139 (68.35%), Query Frame = 1
Query:  274 FEESTVQENISPLKDSLPK-ILPAKKSSRKNPWGQETYSDLIEAAINSHPNQMATLQQIYEFISKNNKYFAERVDATSSAGWKNSIRHNLSLHDKFVKCPKKNENMKSSLWSINT----KCYKRERSNSMDC---KRSG 666
               S    ++ P+    P    P KKSSR+NPWG ETYSDLI  AI+S+P+Q ATLQQIY+FI  N +YF ER D TSSAGWKNSIRHNLSLHD+F KCPK ++N KSS W INT    K Y R R+ SMD    KRSG
Sbjct:  217 VSSSAAVTSVVPINTPAPSSTTPVKKSSRRNPWGSETYSDLISIAIHSYPDQQATLQQIYDFIISNYEYFRERSDPTSSAGWKNSIRHNLSLHDRFTKCPKSSDNTKSSYWRINTEVASKPYVRRRACSMDANNLKRSG 355          
BLAST of Forkhead box protein vs. TrEMBL
Match: A0A430QDE2 (Forkhead box protein O3 OS=Schistosoma bovis OX=6184 GN=DC041_0007345 PE=4 SV=1)

HSP 1 Score: 150.984 bits (380), Expect = 5.713e-37
Identity = 75/117 (64.10%), Postives = 86/117 (73.50%), Query Frame = 1
Query:  337 PAKKSSRKNPWGQETYSDLIEAAINSHPNQMATLQQIYEFISKNNKYFAERVDATSSAGWKNSIRHNLSLHDKFVKCPKKNENMKSSLWSIN----TKCYKRERSNSMD---CKRSG 666
            P KKSSR+NPWG ETYSDLI  AI S+P++ ATLQQIY+FI  + +YF ER D TSSAGWKNSIRHNLSLHD+F KCPK ++N KSS W IN     K Y R R+ SMD    KR G
Sbjct:  187 PVKKSSRRNPWGSETYSDLISVAIRSYPDKQATLQQIYDFIITHYEYFRERSDPTSSAGWKNSIRHNLSLHDRFTKCPKSSDNTKSSYWRINPDVAAKPYVRRRACSMDTTNLKRPG 303          
BLAST of Forkhead box protein vs. TrEMBL
Match: A0A5J4NMI6 (Fork-head domain-containing protein OS=Paragonimus westermani OX=34504 GN=DEA37_0004525 PE=4 SV=1)

HSP 1 Score: 153.68 bits (387), Expect = 3.344e-36
Identity = 72/109 (66.06%), Postives = 85/109 (77.98%), Query Frame = 1
Query:  337 PAKKSSRKNPWGQETYSDLIEAAINSHPNQMATLQQIYEFISKNNKYFAERVDATSSAGWKNSIRHNLSLHDKFVKCPKKNENMKSSLWSINTKC----YKRERSNSMD 651
            P KKSSR+NPWG ETYSDLI  AI+S+P+Q ATLQQIY+FI  + +YF ER D T+SAGWKNSIRHNLSLHD+F KCPK ++N KSS W INT+     Y R R+ SMD
Sbjct:  205 PVKKSSRRNPWGSETYSDLITVAIHSYPDQQATLQQIYDFIITHYEYFRERSDPTTSAGWKNSIRHNLSLHDRFTKCPKSSDNTKSSYWRINTEVAARPYVRRRACSMD 313          
BLAST of Forkhead box protein vs. TrEMBL
Match: A0A1S8XB37 (Fork head domain protein (Fragment) OS=Opisthorchis viverrini OX=6198 GN=X801_00162 PE=4 SV=1)

HSP 1 Score: 152.14 bits (383), Expect = 8.072e-36
Identity = 72/109 (66.06%), Postives = 84/109 (77.06%), Query Frame = 1
Query:  337 PAKKSSRKNPWGQETYSDLIEAAINSHPNQMATLQQIYEFISKNNKYFAERVDATSSAGWKNSIRHNLSLHDKFVKCPKKNENMKSSLWSINT----KCYKRERSNSMD 651
            P KKSSR+NPWG ETYSDLI  AI+S+P+Q ATLQQIY+FI  + +YF ER D  +SAGWKNSIRHNLSLHD+F KCPK ++N KSS W INT    K Y R R+ SMD
Sbjct:  198 PVKKSSRRNPWGPETYSDLISVAIHSYPDQQATLQQIYDFIITHYEYFRERSDPATSAGWKNSIRHNLSLHDRFTKCPKSSDNTKSSYWRINTEVASKPYVRRRACSMD 306          
BLAST of Forkhead box protein vs. Ensembl Cavefish
Match: foxo4 (forkhead box protein O4-like [Source:NCBI gene;Acc:103022611])

HSP 1 Score: 105.916 bits (263), Expect = 6.517e-24
Identity = 56/111 (50.45%), Postives = 74/111 (66.67%), Query Frame = 1
Query:  337 PAKKSSRKNPWGQETYSDLIEAAINSHPNQMATLQQIYEFISKNNKYFAERVDATSSAGWKNSIRHNLSLHDKFVKCPKKNENM-KSSLWSINTKCYK-----RERSNSMD 651
            P K SSR+N WG ++Y+DLI  AI + P +  TL QIYE++ K   YF ++ D+ SSAGWKNSIRHNLSLH+KF++    NE+  KSS W +N +  K     R R+ SMD
Sbjct:   84 PRKGSSRRNAWGNQSYADLISQAIENSPEKRLTLAQIYEWMVKTVPYFKDKGDSNSSAGWKNSIRHNLSLHNKFLRV--HNESTGKSSWWMLNPEGGKPGKAPRRRAASMD 192          
BLAST of Forkhead box protein vs. Ensembl Cavefish
Match: foxo3b (forkhead box O3 [Source:NCBI gene;Acc:103022904])

HSP 1 Score: 103.605 bits (257), Expect = 3.126e-23
Identity = 55/111 (49.55%), Postives = 74/111 (66.67%), Query Frame = 1
Query:  337 PAKKSSRKNPWGQETYSDLIEAAINSHPNQMATLQQIYEFISKNNKYFAERVDATSSAGWKNSIRHNLSLHDKFVKCPKKNENM-KSSLWSINTKCYK-----RERSNSMD 651
            P K SSR+N WG  +Y+DLI  AI S P++  TL QIY+++ ++  YF ++ D+ SSAGWKNSIRHNLSLH +FV+   +NE   KSS W IN +  +     R R+ SMD
Sbjct:  117 PRKTSSRRNAWGNLSYADLITKAIESTPDKRLTLSQIYDWMVRSVPYFKDKGDSNSSAGWKNSIRHNLSLHSRFVRV--QNEGTGKSSWWMINPEGGRGGKAPRRRAVSMD 225          
BLAST of Forkhead box protein vs. Ensembl Cavefish
Match: foxo1b (forkhead box protein O1-B-like [Source:NCBI gene;Acc:103046520])

HSP 1 Score: 102.449 bits (254), Expect = 7.024e-23
Identity = 57/115 (49.57%), Postives = 74/115 (64.35%), Query Frame = 1
Query:  334 LPAKK---SSRKNPWGQETYSDLIEAAINSHPNQMATLQQIYEFISKNNKYFAERVDATSSAGWKNSIRHNLSLHDKFVKCPKKNENM-KSSLWSINTKCYK-----RERSNSMD 651
            LP ++   SSR+N WG  +Y+DLI  AI S P +  TL QIYE++ K+  YF ++ D+ SSAGWKNSIRHNLSLH +FV+   +NE   KSS W +N    K     R R+ SMD
Sbjct:  112 LPGQRKSSSSRRNAWGNMSYADLITRAIESSPEKRLTLSQIYEWMVKSVPYFRDKGDSNSSAGWKNSIRHNLSLHSRFVRV--QNEGTGKSSWWMLNPDGGKSGKSPRRRAASMD 224          
BLAST of Forkhead box protein vs. Ensembl Cavefish
Match: foxo1a (forkhead box O1 [Source:NCBI gene;Acc:103032706])

HSP 1 Score: 102.064 bits (253), Expect = 1.273e-22
Identity = 54/107 (50.47%), Postives = 71/107 (66.36%), Query Frame = 1
Query:  349 SSRKNPWGQETYSDLIEAAINSHPNQMATLQQIYEFISKNNKYFAERVDATSSAGWKNSIRHNLSLHDKFVKCPKKNENM-KSSLWSINTKCYK-----RERSNSMD 651
            SSR+N WG  +Y+DLI  AI S P +  TL QIY+++ K+  YF ++ D+ SSAGWKNSIRHNLSLH +FV+   +NE   KSS W +N +  K     R R+ SMD
Sbjct:  126 SSRRNAWGNMSYADLITKAIESSPEKRLTLSQIYDWMVKSVPYFKDKGDSNSSAGWKNSIRHNLSLHSRFVRV--QNEGTGKSSWWMLNPEGGKSGKSPRRRAASMD 230          
BLAST of Forkhead box protein vs. Ensembl Cavefish
Match: foxo1a (forkhead box O1 [Source:NCBI gene;Acc:103032706])

HSP 1 Score: 102.064 bits (253), Expect = 1.273e-22
Identity = 54/107 (50.47%), Postives = 71/107 (66.36%), Query Frame = 1
Query:  349 SSRKNPWGQETYSDLIEAAINSHPNQMATLQQIYEFISKNNKYFAERVDATSSAGWKNSIRHNLSLHDKFVKCPKKNENM-KSSLWSINTKCYK-----RERSNSMD 651
            SSR+N WG  +Y+DLI  AI S P +  TL QIY+++ K+  YF ++ D+ SSAGWKNSIRHNLSLH +FV+   +NE   KSS W +N +  K     R R+ SMD
Sbjct:  126 SSRRNAWGNMSYADLITKAIESSPEKRLTLSQIYDWMVKSVPYFKDKGDSNSSAGWKNSIRHNLSLHSRFVRV--QNEGTGKSSWWMLNPEGGKSGKSPRRRAASMD 230          
BLAST of Forkhead box protein vs. Ensembl Sea Lamprey
Match: foxk1 (forkhead box K1 [Source:ZFIN;Acc:ZDB-GENE-030131-6402])

HSP 1 Score: 73.559 bits (179), Expect = 3.272e-14
Identity = 48/147 (32.65%), Postives = 73/147 (49.66%), Query Frame = 1
Query:  274 FEESTVQENISPLKDSLPKILPAKKSSRKNPWGQETYSDLIEAAINSHPNQMATLQQIYEFISKNNKYFAERVDATSSAGWKNSIRHNLSLHDKFVKCPKKNENM-KSSLWSINT--------KCYKRERSNSMDCKRSGVDLIARR 687
            F +S  ++   PL +S            K P+   +Y+ LI  AI S  ++  TL  IY +ISK+  Y+       S  GW+NSIRHNLSL+  FVK P+  E+  K S W I+         + Y++ R+  + C R+   L++ R
Sbjct:  183 FAQSAAEKEAEPLDES------------KPPY---SYAQLIVQAITSAASKQLTLSGIYAYISKHYPYYR-----ASDKGWQNSIRHNLSLNRYFVKVPRSQEDPGKGSFWRIDPASEGKLAEQAYRKRRARGVPCFRAPFGLLSSR 309          
BLAST of Forkhead box protein vs. Ensembl Sea Lamprey
Match: foxk1 (forkhead box K1 [Source:ZFIN;Acc:ZDB-GENE-030131-6402])

HSP 1 Score: 73.559 bits (179), Expect = 3.283e-14
Identity = 48/147 (32.65%), Postives = 73/147 (49.66%), Query Frame = 1
Query:  274 FEESTVQENISPLKDSLPKILPAKKSSRKNPWGQETYSDLIEAAINSHPNQMATLQQIYEFISKNNKYFAERVDATSSAGWKNSIRHNLSLHDKFVKCPKKNENM-KSSLWSINT--------KCYKRERSNSMDCKRSGVDLIARR 687
            F +S  ++   PL +S            K P+   +Y+ LI  AI S  ++  TL  IY +ISK+  Y+       S  GW+NSIRHNLSL+  FVK P+  E+  K S W I+         + Y++ R+  + C R+   L++ R
Sbjct:  183 FAQSAAEKEAEPLDES------------KPPY---SYAQLIVQAITSAASKQLTLSGIYAYISKHYPYYR-----ASDKGWQNSIRHNLSLNRYFVKVPRSQEDPGKGSFWRIDPASEGKLAEQAYRKRRARGVPCFRAPFGLLSSR 309          
BLAST of Forkhead box protein vs. Ensembl Sea Lamprey
Match: foxi3b (forkhead box I3b [Source:ZFIN;Acc:ZDB-GENE-031126-4])

HSP 1 Score: 68.9366 bits (167), Expect = 5.594e-13
Identity = 43/128 (33.59%), Postives = 67/128 (52.34%), Query Frame = 1
Query:  361 NPW----GQE----------TYSDLIEAAINSHPNQMATLQQIYEFISKNNKYFAERVDATSSAGWKNSIRHNLSLHDKFVKCPKKNENM-KSSLWSINTKC--------YKRERSNSMDCKRSGVDL 675
            NPW    GQ+          +YS LI  AI   P +  TL QIY+++++N  ++ +     S AGW+NSIRHNLSL+D F K P+ +++  K + W ++  C        ++R+R    D   +G  L
Sbjct:  103 NPWLSYQGQQDFFRLVRPPYSYSALIAMAIQHTPEKRLTLSQIYQYVAENYPFYKK-----SKAGWQNSIRHNLSLNDCFKKVPRDDDDPGKGNYWILDPNCEKMFDNGNFRRKRKRKSDMSPNGTAL 225          
BLAST of Forkhead box protein vs. Ensembl Sea Lamprey
Match: foxj3 (forkhead box J3 [Source:ZFIN;Acc:ZDB-GENE-101005-1])

HSP 1 Score: 68.9366 bits (167), Expect = 9.125e-13
Identity = 40/98 (40.82%), Postives = 58/98 (59.18%), Query Frame = 1
Query:  379 TYSDLIEAAINSHPNQMATLQQIYEFISKNNKYFAERVDATSSAGWKNSIRHNLSLHDKFVKCPK-KNENMKSSLWSIN---------TKCYKRERSN 642
            +Y++LI  AINS   +  TL +IY++I  N  Y+ E     +  GWKNSIRHNLSL+  F+K P+ +++  K S W+I+         T+  KR RSN
Sbjct:   72 SYANLITFAINSSARKRMTLSEIYQWICDNFPYYKE-----AGIGWKNSIRHNLSLNKCFIKVPRSRDDPGKGSYWAIDQNPSDENSSTRPKKRPRSN 164          
BLAST of Forkhead box protein vs. Ensembl Sea Lamprey
Match: foxk1 (forkhead box K1 [Source:ZFIN;Acc:ZDB-GENE-030131-6402])

HSP 1 Score: 65.4698 bits (158), Expect = 2.417e-12
Identity = 38/112 (33.93%), Postives = 59/112 (52.68%), Query Frame = 1
Query:  379 TYSDLIEAAINSHPNQMATLQQIYEFISKNNKYFAERVDATSSAGWKNSIRHNLSLHDKFVKCPK-KNENMKSSLWSINT--------KCYKRERSNSMDCKRSGVDLIARR 687
            +Y+ LI  AI S  ++  TL  IY  I+K+  Y+      T+  GW+NSIRHNLSL+  FVK P+ + E  K S W I+         + +++ R   + C R+    ++ R
Sbjct:  131 SYAQLIVQAITSALDKQLTLSGIYAHITKHYPYYR-----TADKGWQNSIRHNLSLNRYFVKVPRSQEEPGKGSFWRIDPPSEGKLAEQAFRKRRQRGVPCFRTPFGPLSSR 237          
BLAST of Forkhead box protein vs. Ensembl Yeast
Match: FKH2 (Forkhead family transcription factor; rate-limiting activator of replication origins; evolutionarily conserved regulator of lifespan; binds multiple chromosomal elements with distinct specificities, cell cycle dynamics; positively regulates transcriptional elongation; facilitates clustering, activation of early-firing replication origins; negative role in chromatin silencing at HML and HMR; major role in expression of G2/M phase genes; relocalizes to cytosol under hypoxia [Source:SGD;Acc:S000005012])

HSP 1 Score: 61.2326 bits (147), Expect = 2.113e-10
Identity = 38/99 (38.38%), Postives = 57/99 (57.58%), Query Frame = 1
Query:  379 TYSDLIEAAINSHPNQMATLQQIYEFISKNNKY--FAERVDATSSAGWKNSIRHNLSLHDKFVKCPKK-NENMKSSLWSINTKCYKRERSNSMDCKRSG 666
            +Y+ +I  AI S P  + +L  IY++IS N  Y  FA+       +GW+NSIRHNLSL+  F K P++ NE  K   W I ++ Y++E  N  +  + G
Sbjct:  344 SYATMITQAILSSPEGVISLADIYKYISSNYAYYRFAK-------SGWQNSIRHNLSLNKAFEKVPRRPNEPGKGMKWRI-SESYQQEFLNKWNTGKVG 434          
BLAST of Forkhead box protein vs. Ensembl Yeast
Match: FKH1 (Forkhead family transcription factor; rate-limiting replication origin activator; evolutionarily conserved lifespan regulator; binds multiple chromosomal elements with distinct specificities, cell cycle dynamics; regulates transcription elongation, chromatin silencing at mating loci, expression of G2/M phase genes; facilitates clustering, activation of early-firing replication origins; binds HML recombination enhancer, regulates donor preference during mating-type switching [Source:SGD;Acc:S000001393])

HSP 1 Score: 53.1434 bits (126), Expect = 5.294e-8
Identity = 30/79 (37.97%), Postives = 43/79 (54.43%), Query Frame = 1
Query:  376 ETYSDLIEAAINSHPNQMATLQQIYEFISKNNKYFAERVDATSSAGWKNSIRHNLSLHDKFVKCPKK-NENMKSSLWSI 609
            ++Y+ +I  AI S P    +L  IY+FIS N  ++       S   W+NS+RHNLSL+  F K PK+  +  K   W I
Sbjct:  306 QSYASMITQAILSTPEGSISLADIYKFISDNYAFYR-----FSQMAWQNSVRHNLSLNKAFEKVPKRAGQQGKGMNWKI 379          
BLAST of Forkhead box protein vs. Ensembl Yeast
Match: HCM1 (Forkhead transcription factor; drives S-phase activation of genes involved in chromosome segregation, spindle dynamics, budding; also activates genes involved in respiration, use of alternative energy sources (like proline), NAD synthesis, oxidative stress resistance; key factor in early adaptation to nutrient deficiency and diauxic shift; suppressor of calmodulin mutants with specific SPB assembly defects; ortholog of C. elegans lifespan regulator PHA-4 [Source:SGD;Acc:S000000661])

HSP 1 Score: 50.0618 bits (118), Expect = 5.720e-7
Identity = 35/98 (35.71%), Postives = 53/98 (54.08%), Query Frame = 1
Query:  352 SRKNPWGQETYSDLIEAAINSHPNQMATLQQIYEFISKNNKYFAERVDATSSAGWKNSIRHNLSLHDKFVKCPKKNENMKSSLWSI----NTKCYKRE 633
            ++K P+   +Y+ LI  AI        TL QIY +I  +  Y+ ++      A W+NSIRHNLSL+D F+K  +K+ + K   W +     TK +K E
Sbjct:  107 AKKPPY---SYATLICLAILQSQEGKLTLSQIYHWIHVHFPYYKQK-----DASWQNSIRHNLSLNDAFIKT-EKSCDGKGHFWEVRPGAETKFFKGE 195          
BLAST of Forkhead box protein vs. Ensembl Nematostella
Match: EDO31077 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7SYZ1])

HSP 1 Score: 83.1889 bits (204), Expect = 1.179e-19
Identity = 41/87 (47.13%), Postives = 55/87 (63.22%), Query Frame = 1
Query:  361 NPWGQETYSDLIEAAINSHPNQMATLQQIYEFISKNNKYFAERVDATSSAGWKNSIRHNLSLHDKFVKCPKKNENMKSSLWSINTKC 621
            NPWG E+YS++I  AI S P+Q ATL  IYE+I  N  YFA++ D  S+ GWKN+IRH LS+  +F +    +    SSLW+   K 
Sbjct:    2 NPWGSESYSEMISKAIMSCPSQEATLHTIYEWIVNNVSYFADKADYPSTHGWKNAIRHTLSIRKRFTRIIDISSP-HSSLWTFTHKA 87          
BLAST of Forkhead box protein vs. Ensembl Nematostella
Match: EDO31996 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7SWD7])

HSP 1 Score: 76.6406 bits (187), Expect = 1.811e-17
Identity = 38/87 (43.68%), Postives = 50/87 (57.47%), Query Frame = 1
Query:  349 SSRKNPWGQETYSDLIEAAINSHPNQMATLQQIYEFISKNNKYFAERVDATSSAGWKNSIRHNLSLHDKFVKCPKKNENMKSSLWSI 609
              +KNPWG  +YSDLI  AI+    Q  TL QIY++   N  YF  +    S+ GWKN+IRH LSL  +FV+ P    N   S W++
Sbjct:    1 GEKKNPWGNASYSDLIARAIDQSKFQKLTLPQIYDWFVINVPYFKAKEHLPSTKGWKNAIRHTLSLRQRFVRLPDPG-NPYRSWWTV 86          
BLAST of Forkhead box protein vs. Ensembl Nematostella
Match: EDO47844 (Forkhead domain protein O2-like protein; Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7RKZ3])

HSP 1 Score: 75.8702 bits (185), Expect = 3.221e-17
Identity = 39/85 (45.88%), Postives = 49/85 (57.65%), Query Frame = 1
Query:  355 RKNPWGQETYSDLIEAAINSHPNQMATLQQIYEFISKNNKYFAERVDATSSAGWKNSIRHNLSLHDKFVKCPKKNENMKSSLWSI 609
            +K PWG  +YSDLI  AI     Q  TL QIYE+  +N  YF +R    S+ GWKN+IRH LSL  +FV+      N   S WS+
Sbjct:    1 KKKPWGNASYSDLIARAITQSTKQKLTLPQIYEWFVENVSYFRDREHLPSTKGWKNAIRHTLSLRQRFVRTVDPT-NPYRSWWSL 84          
BLAST of Forkhead box protein vs. Ensembl Nematostella
Match: EDO27489 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7T943])

HSP 1 Score: 65.0846 bits (157), Expect = 1.054e-13
Identity = 30/57 (52.63%), Postives = 39/57 (68.42%), Query Frame = 1
Query:  349 SSRKNPWGQETYSDLIEAAINSHPNQMATLQQIYEFISKNNKYFAERVDATSSAGWK 519
            S  +NPWG E+YS++I  AI S P+Q ATL  IYE+I  N  YFA++ D  S+ GWK
Sbjct:    1 SKTQNPWGSESYSEMISKAIMSCPSQEATLHTIYEWIVNNVSYFADKADYPSTHGWK 57          
BLAST of Forkhead box protein vs. Ensembl Nematostella
Match: EDO36951 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7SH30])

HSP 1 Score: 66.2402 bits (160), Expect = 1.122e-13
Identity = 36/82 (43.90%), Postives = 49/82 (59.76%), Query Frame = 1
Query:  379 TYSDLIEAAINSHPNQMATLQQIYEFISKNNKYFAERVDATSSAGWKNSIRHNLSLHDKFVKCPK-KNENMKSSLWSINTKC 621
            +Y+ LI  AI S  ++  TL  IY  I+KN  Y+      T+  GW+NSIRHNLSL+  FVK P+ ++E  K S W I+  C
Sbjct:    8 SYAQLIVQAILSATDKQLTLSGIYAHITKNYPYYR-----TADKGWQNSIRHNLSLNRYFVKVPRAQDEPGKGSFWRIDPSC 84          
BLAST of Forkhead box protein vs. Ensembl Medaka
Match: foxo4 (forkhead box protein O6 [Source:NCBI gene;Acc:110015734])

HSP 1 Score: 103.605 bits (257), Expect = 2.966e-23
Identity = 55/109 (50.46%), Postives = 73/109 (66.97%), Query Frame = 1
Query:  343 KKSSRKNPWGQETYSDLIEAAINSHPNQMATLQQIYEFISKNNKYFAERVDATSSAGWKNSIRHNLSLHDKFVKCPKKNENM-KSSLWSINTKCYK-----RERSNSMD 651
            K SSR+N WG ++Y+DLI  AI + P +  TL QIYE++ K   YF ++ D+ SSAGWKNSIRHNLSLH+KF++    NE+  KSS W +N +  K     R R+ SMD
Sbjct:   89 KGSSRRNAWGNQSYADLISQAIENSPEKRLTLAQIYEWMVKTVPYFRDKGDSNSSAGWKNSIRHNLSLHNKFLRV--HNESTGKSSWWMLNPEGGKTGKAPRRRAASMD 195          
BLAST of Forkhead box protein vs. Ensembl Medaka
Match: foxo3 (forkhead box O3 [Source:NCBI gene;Acc:100301621])

HSP 1 Score: 103.605 bits (257), Expect = 3.201e-23
Identity = 55/111 (49.55%), Postives = 73/111 (65.77%), Query Frame = 1
Query:  337 PAKKSSRKNPWGQETYSDLIEAAINSHPNQMATLQQIYEFISKNNKYFAERVDATSSAGWKNSIRHNLSLHDKFVKCPKKNENM-KSSLWSINTKCYK-----RERSNSMD 651
            P K SSR+N WG  +Y+DLI  AI S P +  TL QIY+++ ++  YF ++ D+ SSAGWKNSIRHNLSLH +F++   +NE   KSS W IN +  K     R R+ SMD
Sbjct:  125 PRKTSSRRNAWGNLSYADLITQAIESSPEKRLTLSQIYDWMVRSIPYFKDKGDSNSSAGWKNSIRHNLSLHSRFIRV--QNEGTGKSSWWMINPEGGKGGKAPRRRAVSMD 233          
BLAST of Forkhead box protein vs. Ensembl Medaka
Match: foxo3 (forkhead box O3 [Source:NCBI gene;Acc:100301621])

HSP 1 Score: 103.605 bits (257), Expect = 3.201e-23
Identity = 55/111 (49.55%), Postives = 73/111 (65.77%), Query Frame = 1
Query:  337 PAKKSSRKNPWGQETYSDLIEAAINSHPNQMATLQQIYEFISKNNKYFAERVDATSSAGWKNSIRHNLSLHDKFVKCPKKNENM-KSSLWSINTKCYK-----RERSNSMD 651
            P K SSR+N WG  +Y+DLI  AI S P +  TL QIY+++ ++  YF ++ D+ SSAGWKNSIRHNLSLH +F++   +NE   KSS W IN +  K     R R+ SMD
Sbjct:  125 PRKTSSRRNAWGNLSYADLITQAIESSPEKRLTLSQIYDWMVRSIPYFKDKGDSNSSAGWKNSIRHNLSLHSRFIRV--QNEGTGKSSWWMINPEGGKGGKAPRRRAVSMD 233          
BLAST of Forkhead box protein vs. Ensembl Medaka
Match: ENSORLT00000040588.1 (pep primary_assembly:ASM223467v1:22:547169:550450:1 gene:ENSORLG00000024046.1 transcript:ENSORLT00000040588.1 gene_biotype:protein_coding transcript_biotype:protein_coding)

HSP 1 Score: 102.449 bits (254), Expect = 6.511e-23
Identity = 53/109 (48.62%), Postives = 73/109 (66.97%), Query Frame = 1
Query:  343 KKSSRKNPWGQETYSDLIEAAINSHPNQMATLQQIYEFISKNNKYFAERVDATSSAGWKNSIRHNLSLHDKFVKCPKKNENM-KSSLWSINTKCYK-----RERSNSMD 651
            K S+R+N WG  +Y+DLI  AI+  P++  TL QIY+++ ++  YF ++ D+ SSAGWKNSIRHNLSLH +FVK   +NE   KSS W +N +  K     R R+ SMD
Sbjct:  115 KSSARRNAWGNYSYADLITQAIDGSPDKRLTLAQIYDWMVRSVPYFKDKGDSNSSAGWKNSIRHNLSLHSRFVKV--QNEGTGKSSWWVVNPEGGKGGKAPRRRAVSMD 221          
BLAST of Forkhead box protein vs. Ensembl Medaka
Match: ENSORLT00000009665.2 (forkhead box protein O1-A [Source:NCBI gene;Acc:101164740])

HSP 1 Score: 99.7525 bits (247), Expect = 5.809e-22
Identity = 54/107 (50.47%), Postives = 71/107 (66.36%), Query Frame = 1
Query:  349 SSRKNPWGQETYSDLIEAAINSHPNQMATLQQIYEFISKNNKYFAERVDATSSAGWKNSIRHNLSLHDKFVKCPKKNENM-KSSLWSINTKCYK-----RERSNSMD 651
            SSR+N WG  +Y+DLI  AI S P +  TL QIY+++ K+  YF ++ D+ SSAGWKNSIRHNLSLH +FV+   +NE   KSS W +N +  K     R R+ SMD
Sbjct:  121 SSRRNAWGNMSYADLITKAIESSPEKRLTLSQIYDWMVKSVPYFKDKGDSNSSAGWKNSIRHNLSLHSRFVRL--QNEGTGKSSWWMLNPEGGKNGKSPRRRAVSMD 225          
BLAST of Forkhead box protein vs. Planmine SMEST
Match: SMESG000037781.1 (SMESG000037781.1)

HSP 1 Score: 652.514 bits (1682), Expect = 0.000e+0
Identity = 333/333 (100.00%), Postives = 333/333 (100.00%), Query Frame = 1
Query:  124 MNNMLDDCHSPEFRARSQTWGGNDNSYRSRIIEADLSQKYTTFASDSYTSFEESTVQENISPLKDSLPKILPAKKSSRKNPWGQETYSDLIEAAINSHPNQMATLQQIYEFISKNNKYFAERVDATSSAGWKNSIRHNLSLHDKFVKCPKKNENMKSSLWSINTKCYKRERSNSMDCKRSGVDLIARRKLLKEQRRHXXXXXXXXXXXXXXXXXDKYTAATDDNSIHKLSPNNQSSFTYDSAESAMETISDFIYKDNKLKYRSPQTIHESNKEMQLDSSYNKYDCHLHQTLHEDLQRLDVNSMEHYHYKKDQNFNYNKSQCLDFHRAALEYSR 1122
            MNNMLDDCHSPEFRARSQTWGGNDNSYRSRIIEADLSQKYTTFASDSYTSFEESTVQENISPLKDSLPKILPAKKSSRKNPWGQETYSDLIEAAINSHPNQMATLQQIYEFISKNNKYFAERVDATSSAGWKNSIRHNLSLHDKFVKCPKKNENMKSSLWSINTKCYKRERSNSMDCKRSGVDLIARRKLLKEQRRHISSNSNIVSNSKISPNSDKYTAATDDNSIHKLSPNNQSSFTYDSAESAMETISDFIYKDNKLKYRSPQTIHESNKEMQLDSSYNKYDCHLHQTLHEDLQRLDVNSMEHYHYKKDQNFNYNKSQCLDFHRAALEYSR
Sbjct:    1 MNNMLDDCHSPEFRARSQTWGGNDNSYRSRIIEADLSQKYTTFASDSYTSFEESTVQENISPLKDSLPKILPAKKSSRKNPWGQETYSDLIEAAINSHPNQMATLQQIYEFISKNNKYFAERVDATSSAGWKNSIRHNLSLHDKFVKCPKKNENMKSSLWSINTKCYKRERSNSMDCKRSGVDLIARRKLLKEQRRHISSNSNIVSNSKISPNSDKYTAATDDNSIHKLSPNNQSSFTYDSAESAMETISDFIYKDNKLKYRSPQTIHESNKEMQLDSSYNKYDCHLHQTLHEDLQRLDVNSMEHYHYKKDQNFNYNKSQCLDFHRAALEYSR 333          
BLAST of Forkhead box protein vs. Planmine SMEST
Match: SMESG000037781.1 (SMESG000037781.1)

HSP 1 Score: 646.351 bits (1666), Expect = 0.000e+0
Identity = 330/330 (100.00%), Postives = 330/330 (100.00%), Query Frame = 1
Query:  133 MLDDCHSPEFRARSQTWGGNDNSYRSRIIEADLSQKYTTFASDSYTSFEESTVQENISPLKDSLPKILPAKKSSRKNPWGQETYSDLIEAAINSHPNQMATLQQIYEFISKNNKYFAERVDATSSAGWKNSIRHNLSLHDKFVKCPKKNENMKSSLWSINTKCYKRERSNSMDCKRSGVDLIARRKLLKEQRRHXXXXXXXXXXXXXXXXXDKYTAATDDNSIHKLSPNNQSSFTYDSAESAMETISDFIYKDNKLKYRSPQTIHESNKEMQLDSSYNKYDCHLHQTLHEDLQRLDVNSMEHYHYKKDQNFNYNKSQCLDFHRAALEYSR 1122
            MLDDCHSPEFRARSQTWGGNDNSYRSRIIEADLSQKYTTFASDSYTSFEESTVQENISPLKDSLPKILPAKKSSRKNPWGQETYSDLIEAAINSHPNQMATLQQIYEFISKNNKYFAERVDATSSAGWKNSIRHNLSLHDKFVKCPKKNENMKSSLWSINTKCYKRERSNSMDCKRSGVDLIARRKLLKEQRRHISSNSNIVSNSKISPNSDKYTAATDDNSIHKLSPNNQSSFTYDSAESAMETISDFIYKDNKLKYRSPQTIHESNKEMQLDSSYNKYDCHLHQTLHEDLQRLDVNSMEHYHYKKDQNFNYNKSQCLDFHRAALEYSR
Sbjct:    1 MLDDCHSPEFRARSQTWGGNDNSYRSRIIEADLSQKYTTFASDSYTSFEESTVQENISPLKDSLPKILPAKKSSRKNPWGQETYSDLIEAAINSHPNQMATLQQIYEFISKNNKYFAERVDATSSAGWKNSIRHNLSLHDKFVKCPKKNENMKSSLWSINTKCYKRERSNSMDCKRSGVDLIARRKLLKEQRRHISSNSNIVSNSKISPNSDKYTAATDDNSIHKLSPNNQSSFTYDSAESAMETISDFIYKDNKLKYRSPQTIHESNKEMQLDSSYNKYDCHLHQTLHEDLQRLDVNSMEHYHYKKDQNFNYNKSQCLDFHRAALEYSR 330          
BLAST of Forkhead box protein vs. Planmine SMEST
Match: SMESG000075929.1 (SMESG000075929.1)

HSP 1 Score: 67.3958 bits (163), Expect = 1.029e-12
Identity = 44/110 (40.00%), Postives = 60/110 (54.55%), Query Frame = 1
Query:  286 TVQENISPLKDSLPKILPAKKSSRKNPWGQETYSDLIEAAINSHPNQMATLQQIYEFISKNNKYFAERVDATSSAGWKNSIRHNLSLHDKFVKCPKKNENM-KSSLWSIN 612
            TV +NI        KI   K+   K P+   +Y  LI  AI + P Q  TL +IYE++S++ K+F          GWKNSIRHNLSL+D F+K PK    + K   W++N
Sbjct:   18 TVDQNI--------KIALTKEIYLKPPF---SYISLIAMAIQASPYQQCTLNEIYEYLSEHFKFFRGEYQ-----GWKNSIRHNLSLNDCFIKIPKGFGRIGKGHYWTMN 111          
BLAST of Forkhead box protein vs. Planmine SMEST
Match: SMESG000075929.1 (SMESG000075929.1)

HSP 1 Score: 65.855 bits (159), Expect = 3.598e-12
Identity = 35/79 (44.30%), Postives = 48/79 (60.76%), Query Frame = 1
Query:  379 TYSDLIEAAINSHPNQMATLQQIYEFISKNNKYFAERVDATSSAGWKNSIRHNLSLHDKFVKCPKKNENM-KSSLWSIN 612
            +Y  LI  AI + P Q  TL +IYE++S++ K+F          GWKNSIRHNLSL+D F+K PK    + K   W++N
Sbjct:   40 SYISLIAMAIQASPYQQCTLNEIYEYLSEHFKFFRGEYQ-----GWKNSIRHNLSLNDCFIKIPKGFGRIGKGHYWTMN 113          
BLAST of Forkhead box protein vs. Planmine SMEST
Match: SMESG000015673.1 (SMESG000015673.1)

HSP 1 Score: 65.0846 bits (157), Expect = 4.598e-11
Identity = 37/104 (35.58%), Postives = 61/104 (58.65%), Query Frame = 1
Query:  325 PKILPAKKSSR---KNPWGQETYSDLIEAAINSHPNQMATLQQIYEFISKNNKYFAERVDATSSAGWKNSIRHNLSLHDKFVKCPKKNEN-MKSSLWSINTKCY 624
            P +  ++  SR   K P+   +Y  LI  A+++HP +  TL  IY+FI +   Y+ E     +  GW+NSIRHNLSL++ F+K P+ ++   K S W+++ + Y
Sbjct:   59 PNMSSSRNPSRDLVKPPY---SYIALITMAVHAHPEKKVTLSGIYQFIMEKFPYYRE-----NKQGWQNSIRHNLSLNECFIKIPRDDKKPGKGSYWALHPQAY 154          
The following BLAST results are available for this feature:
BLAST of Forkhead box protein vs. Ensembl Human
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Human e!99)
Total hits: 5
Match NameE-valueIdentityDescription
FOXO45.463e-2540.74forkhead box O4 [Source:HGNC Symbol;Acc:HGNC:7139][more]
FOXO33.129e-2250.45forkhead box O3 [Source:HGNC Symbol;Acc:HGNC:3821][more]
FOXO33.129e-2250.45forkhead box O3 [Source:HGNC Symbol;Acc:HGNC:3821][more]
FOXO63.790e-2249.07forkhead box O6 [Source:HGNC Symbol;Acc:HGNC:24814... [more]
FOXO63.932e-2249.07forkhead box O6 [Source:HGNC Symbol;Acc:HGNC:24814... [more]
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BLAST of Forkhead box protein vs. Ensembl Celegans
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99)
Total hits: 5
Match NameE-valueIdentityDescription
daf-167.117e-2244.64Forkhead box protein O [Source:UniProtKB/Swiss-Pr... [more]
daf-167.389e-2244.64Forkhead box protein O [Source:UniProtKB/Swiss-Pr... [more]
daf-161.416e-2144.64Forkhead box protein O [Source:UniProtKB/Swiss-Pr... [more]
daf-161.485e-2144.64Forkhead box protein O [Source:UniProtKB/Swiss-Pr... [more]
daf-161.485e-2144.64Forkhead box protein O [Source:UniProtKB/Swiss-Pr... [more]
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BLAST of Forkhead box protein vs. Ensembl Fly
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99)
Total hits: 5
Match NameE-valueIdentityDescription
foxo5.868e-2235.94gene:FBgn0038197 transcript:FBtr0082887[more]
foxo5.868e-2235.94gene:FBgn0038197 transcript:FBtr0082886[more]
foxo7.121e-2235.94gene:FBgn0038197 transcript:FBtr0346723[more]
foxo8.206e-2235.94gene:FBgn0038197 transcript:FBtr0337094[more]
foxo8.206e-2235.94gene:FBgn0038197 transcript:FBtr0305052[more]
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BLAST of Forkhead box protein vs. Ensembl Zebrafish
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99)
Total hits: 5
Match NameE-valueIdentityDescription
foxo42.051e-2347.33forkhead box O4 [Source:ZFIN;Acc:ZDB-GENE-150311-1... [more]
foxo42.051e-2347.33forkhead box O4 [Source:ZFIN;Acc:ZDB-GENE-150311-1... [more]
foxo3a2.817e-2344.80forkhead box O3A [Source:ZFIN;Acc:ZDB-GENE-050116-... [more]
foxo1b5.661e-2351.40forkhead box O1 b [Source:NCBI gene;Acc:567969][more]
foxo6a7.155e-2338.15forkhead box O6 a [Source:ZFIN;Acc:ZDB-GENE-110914... [more]
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BLAST of Forkhead box protein vs. Ensembl Xenopus
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99)
Total hits: 5
Match NameE-valueIdentityDescription
FOXO44.521e-2349.55forkhead box O4 [Source:NCBI gene;Acc:100492831][more]
FOXO44.883e-2349.55forkhead box O4 [Source:NCBI gene;Acc:100492831][more]
foxo12.469e-2251.40forkhead box O1 [Source:NCBI gene;Acc:493378][more]
c2cd4c1.706e-2149.07C2 calcium-dependent domain containing 4C [Source:... [more]
foxo38.635e-2148.62forkhead box O3 [Source:NCBI gene;Acc:100125025][more]
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BLAST of Forkhead box protein vs. Ensembl Mouse
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99)
Total hits: 5
Match NameE-valueIdentityDescription
Foxo49.542e-2539.89forkhead box O4 [Source:MGI Symbol;Acc:MGI:1891915... [more]
Foxo31.977e-2250.45forkhead box O3 [Source:MGI Symbol;Acc:MGI:1890081... [more]
Foxo31.977e-2250.45forkhead box O3 [Source:MGI Symbol;Acc:MGI:1890081... [more]
Foxo31.977e-2250.45forkhead box O3 [Source:MGI Symbol;Acc:MGI:1890081... [more]
Foxo63.125e-2249.07forkhead box O6 [Source:MGI Symbol;Acc:MGI:2676586... [more]
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BLAST of Forkhead box protein vs. UniProt/SwissProt
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt)
Total hits: 5
Match NameE-valueIdentityDescription
sp|P98177|FOXO4_HUMAN2.624e-2440.74Forkhead box protein O4 OS=Homo sapiens OX=9606 GN... [more]
sp|Q9WVH3|FOXO4_MOUSE6.674e-2439.89Forkhead box protein O4 OS=Mus musculus OX=10090 G... [more]
sp|A3RK75|FX1AB_DANRE4.273e-2251.40Forkhead box protein O1-B OS=Danio rerio OX=7955 G... [more]
sp|Q66JJ0|FOXO1_XENTR1.308e-2151.40Forkhead box protein O1 OS=Xenopus tropicalis OX=8... [more]
sp|Q6EUW2|FOXO1_XENLA1.358e-2151.40Forkhead box protein O1 OS=Xenopus laevis OX=8355 ... [more]
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BLAST of Forkhead box protein vs. TrEMBL
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL)
Total hits: 5
Match NameE-valueIdentityDescription
A0A4E0S0Z03.295e-3958.99Forkhead box protein O OS=Fasciola hepatica OX=619... [more]
A0A504YWL75.384e-3958.99Forkhead box protein O OS=Fasciola gigantica OX=46... [more]
A0A430QDE25.713e-3764.10Forkhead box protein O3 OS=Schistosoma bovis OX=61... [more]
A0A5J4NMI63.344e-3666.06Fork-head domain-containing protein OS=Paragonimus... [more]
A0A1S8XB378.072e-3666.06Fork head domain protein (Fragment) OS=Opisthorchi... [more]
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BLAST of Forkhead box protein vs. Ensembl Cavefish
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99)
Total hits: 5
Match NameE-valueIdentityDescription
foxo46.517e-2450.45forkhead box protein O4-like [Source:NCBI gene;Acc... [more]
foxo3b3.126e-2349.55forkhead box O3 [Source:NCBI gene;Acc:103022904][more]
foxo1b7.024e-2349.57forkhead box protein O1-B-like [Source:NCBI gene;A... [more]
foxo1a1.273e-2250.47forkhead box O1 [Source:NCBI gene;Acc:103032706][more]
foxo1a1.273e-2250.47forkhead box O1 [Source:NCBI gene;Acc:103032706][more]
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BLAST of Forkhead box protein vs. Ensembl Sea Lamprey
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99)
Total hits: 5
Match NameE-valueIdentityDescription
foxk13.272e-1432.65forkhead box K1 [Source:ZFIN;Acc:ZDB-GENE-030131-6... [more]
foxk13.283e-1432.65forkhead box K1 [Source:ZFIN;Acc:ZDB-GENE-030131-6... [more]
foxi3b5.594e-1333.59forkhead box I3b [Source:ZFIN;Acc:ZDB-GENE-031126-... [more]
foxj39.125e-1340.82forkhead box J3 [Source:ZFIN;Acc:ZDB-GENE-101005-1... [more]
foxk12.417e-1233.93forkhead box K1 [Source:ZFIN;Acc:ZDB-GENE-030131-6... [more]
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BLAST of Forkhead box protein vs. Ensembl Yeast
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46)
Total hits: 3
Match NameE-valueIdentityDescription
FKH22.113e-1038.38Forkhead family transcription factor; rate-limitin... [more]
FKH15.294e-837.97Forkhead family transcription factor; rate-limitin... [more]
HCM15.720e-735.71Forkhead transcription factor; drives S-phase acti... [more]
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BLAST of Forkhead box protein vs. Ensembl Nematostella
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46)
Total hits: 5
Match NameE-valueIdentityDescription
EDO310771.179e-1947.13Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7... [more]
EDO319961.811e-1743.68Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7... [more]
EDO478443.221e-1745.88Forkhead domain protein O2-like protein; Predicted... [more]
EDO274891.054e-1352.63Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7... [more]
EDO369511.122e-1343.90Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7... [more]
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BLAST of Forkhead box protein vs. Ensembl Medaka
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99)
Total hits: 5
Match NameE-valueIdentityDescription
foxo42.966e-2350.46forkhead box protein O6 [Source:NCBI gene;Acc:1100... [more]
foxo33.201e-2349.55forkhead box O3 [Source:NCBI gene;Acc:100301621][more]
foxo33.201e-2349.55forkhead box O3 [Source:NCBI gene;Acc:100301621][more]
ENSORLT00000040588.16.511e-2348.62pep primary_assembly:ASM223467v1:22:547169:550450:... [more]
ENSORLT00000009665.25.809e-2250.47forkhead box protein O1-A [Source:NCBI gene;Acc:10... [more]
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BLAST of Forkhead box protein vs. Planmine SMEST
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST)
Total hits: 5
Match NameE-valueIdentityDescription
SMESG000037781.10.000e+0100.00SMESG000037781.1[more]
SMESG000037781.10.000e+0100.00SMESG000037781.1[more]
SMESG000075929.11.029e-1240.00SMESG000075929.1[more]
SMESG000075929.13.598e-1244.30SMESG000075929.1[more]
SMESG000015673.14.598e-1135.58SMESG000015673.1[more]
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Sequences
The following sequences are available for this feature:

transcript sequence

>SMED30012265 ID=SMED30012265|Name=Forkhead box protein|organism=Schmidtea mediterranea sexual|type=transcript|length=1407bp
CAAATTTGATTTGACATTTTATTGGGTTTTTTTTTGGAGAAAACAATTTT
TTTTTGTTGTTGAGAAATGTTTTCCAATTATCCACTGGAATCGTTATTGA
TTACGAATAGTTATTCTTTAGCTATGAATAACATGCTAGACGATTGCCAT
TCTCCAGAATTCCGAGCCCGATCGCAGACCTGGGGAGGAAATGATAACTC
TTATCGATCGAGAATCATTGAGGCAGATCTTTCTCAGAAATACACGACTT
TTGCCAGCGATTCCTACACATCTTTCGAGGAGTCGACTGTTCAAGAAAAC
ATTTCCCCGTTGAAGGATTCTCTGCCGAAAATTCTTCCAGCAAAAAAATC
ATCGAGAAAAAACCCATGGGGTCAGGAAACGTATTCTGACTTGATTGAAG
CCGCTATCAATTCCCATCCCAATCAAATGGCTACTTTGCAACAAATATAT
GAATTTATTTCCAAGAACAATAAATATTTTGCAGAACGAGTTGATGCTAC
TTCCTCGGCTGGTTGGAAAAATTCGATCCGGCATAATTTGTCACTCCATG
ACAAATTCGTGAAATGCCCGAAAAAAAATGAGAACATGAAAAGCTCGTTG
TGGTCAATTAACACAAAGTGCTACAAACGAGAGCGCTCCAACAGCATGGA
TTGCAAGAGGTCGGGAGTCGATCTAATAGCCAGACGCAAATTGCTAAAGG
AACAACGGCGTCACATTTCAAGCAATTCCAACATTGTATCGAATTCTAAG
ATATCACCCAATTCCGACAAGTACACTGCTGCCACTGACGATAATAGCAT
CCACAAGTTGTCCCCTAACAACCAGTCCTCCTTCACTTATGATAGCGCTG
AGTCGGCCATGGAAACGATTTCAGATTTCATCTATAAAGACAACAAGCTC
AAATATAGATCTCCACAAACAATTCATGAATCAAACAAGGAAATGCAACT
TGATAGTAGCTATAACAAATATGATTGTCATCTCCACCAAACCCTTCATG
AAGACCTACAACGACTCGATGTCAATTCAATGGAACATTACCATTATAAA
AAAGATCAGAATTTTAATTACAACAAATCACAGTGTCTTGATTTCCATCG
GGCTGCTCTTGAATACTCCAGATTTATTGCCGACATATTTATTGATGATG
TTGAATAAGATTGAGAATCAAAAACCTATTTAGTCAACTTCTCGTTTCAT
AGACCAGAATTCATTGATATGTTTGTGTTCTTTTAGAACAAACAATAAGA
TTTTTGATAAACTACAGAACTTTGTATCGTGTTCTTTATTTTACCCGATC
ATGAATGATGGACTATTTTCATATAGAGATGCTTATTTAAATTCACATAT
TTTCTGATTTCATATGTACATACATTTTATGTGTAGCGCCATACAAGCTT
CTTTATT
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protein sequence of SMED30012265-orf-1

>SMED30012265-orf-1 ID=SMED30012265-orf-1|Name=SMED30012265-orf-1|organism=Schmidtea mediterranea sexual|type=polypeptide|length=364bp
MFSNYPLESLLITNSYSLAMNNMLDDCHSPEFRARSQTWGGNDNSYRSRI
IEADLSQKYTTFASDSYTSFEESTVQENISPLKDSLPKILPAKKSSRKNP
WGQETYSDLIEAAINSHPNQMATLQQIYEFISKNNKYFAERVDATSSAGW
KNSIRHNLSLHDKFVKCPKKNENMKSSLWSINTKCYKRERSNSMDCKRSG
VDLIARRKLLKEQRRHISSNSNIVSNSKISPNSDKYTAATDDNSIHKLSP
NNQSSFTYDSAESAMETISDFIYKDNKLKYRSPQTIHESNKEMQLDSSYN
KYDCHLHQTLHEDLQRLDVNSMEHYHYKKDQNFNYNKSQCLDFHRAALEY
SRFIADIFIDDVE*
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Aliases
The feature 'Forkhead box protein' has the following synonyms
Synonym
foxO*
Annotated Terms
The following terms have been associated with this transcript:
Vocabulary: molecular function
TermDefinition
GO:0003677DNA binding
GO:0003700transcription factor activity, sequence-specific DNA binding
GO:0043565sequence-specific DNA binding
Vocabulary: cellular component
TermDefinition
GO:0005634nucleus
Vocabulary: Planarian Anatomy
TermDefinition
PLANA:0000034epidermis
PLANA:0000101muscle cell
PLANA:0000142posterior region of the whole animal
Vocabulary: INTERPRO
TermDefinition
IPR036388WH-like_DNA-bd_sf
IPR036390WH_DNA-bd_sf
IPR001766Fork_head_dom
IPR011991WHTH_DNA-bd_dom
IPR030456TF_fork_head_CS_2
Vocabulary: biological process
TermDefinition
GO:0006355regulation of transcription, DNA-templated
InterPro
Analysis Name: Schmidtea mediteranean smed_20140614 Interproscan
Date Performed: 2020-05-01
IPR TermIPR DescriptionSourceSource TermSource DescriptionAlignment
IPR001766Fork head domainPRINTSPR00053FORKHEADcoord: 150..167
score: 68.61
coord: 122..139
score: 36.6
IPR001766Fork head domainSMARTSM00339forkneu4coord: 99..193
e-value: 8.6E-25
score: 98.4
IPR001766Fork head domainPFAMPF00250Forkheadcoord: 105..186
e-value: 4.1E-23
score: 81.4
IPR001766Fork head domainPROSITEPS50039FORK_HEAD_3coord: 105..214
score: 20.412
IPR036388Winged helix-like DNA-binding domain superfamilyGENE3DG3DSA:1.10.10.10coord: 92..191
e-value: 1.1E-28
score: 100.9
NoneNo IPR availableMOBIDB_LITEmobidb-litedisorder_predictioncoord: 216..236
NoneNo IPR availableMOBIDB_LITEmobidb-litedisorder_predictioncoord: 215..236
NoneNo IPR availablePANTHERPTHR45767FAMILY NOT NAMEDcoord: 64..319
NoneNo IPR availablePANTHERPTHR45767:SF2FORKHEAD BOX PROTEIN Ocoord: 64..319
IPR030456Fork head domain conserved site 2PROSITEPS00658FORK_HEAD_2coord: 150..156
IPR036390Winged helix DNA-binding domain superfamilySUPERFAMILYSSF46785"Winged helix" DNA-binding domaincoord: 98..184