E3 ubiquitin-protein ligase RNF170
Overview
Neoblast Clusters
Zeng et. al., 2018▻ Overview▻ Neoblast Population▻ Sub-lethal Irradiated Surviving X1 and X2 Cell Population
Overview
Single cell RNA-seq of pluripotent neoblasts and its early progeniesWe isolated X1 neoblasts cells enriched in high piwi-1 expression (Neoblast Population), and profiled ∼7,614 individual cells via scRNA-seq. Unsupervised analyses uncovered 12 distinct classes from 7,088 high-quality cells. We designated these classes Nb1 to Nb12 and ordered them based on high (Nb1) to low (Nb12) piwi-1 expression levels. We further defined groups of genes that best classified the cells parsed into 12 distinct cell clusters to generate a scaled expression heat map of discriminative gene sets for each cluster. Expression of each cluster’s gene signatures was validated using multiplex fluorescence in situ hybridization (FISH) co-stained with piwi-1 and largely confirmed the cell clusters revealed by scRNA-seq.We also tested sub-lethal irradiation exposure. To profile rare pluripotent stem cells (PSCs) and avoid interference from immediate progenitor cells, we determined a time point after sub-lethal irradiation (7 DPI) with minimal piwi-1+ cells, followed by isolation and single-cell RNA-seq of 1,200 individual cells derived from X1 (Piwi-1 high) and X2 (Piwi-1 low) cell populations (Sub-lethal Irradiated Surviving X1 and X2 Cell Population)Explore this single cell expression dataset with our NB Cluster Shiny App
Neoblast Population
Sub-lethal Irradiated Surviving X1 and X2 Cell Population
Embryonic Expression
Davies et. al., 2017
Hover the mouse over a column in the graph to view average RPKM values per sample. Embryonic Stages: Y: yolk. S2-S8: Stages 2-8. C4: asexual adult. SX: virgin, sexually mature adult. back to top Anatomical Expression
PAGE et. al., 2020SMED30012240 has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGEPAGE Curations: 26
Homology
BLAST of E3 ubiquitin-protein ligase RNF170 vs. Ensembl Human
Match: RNF170 (ring finger protein 170 [Source:HGNC Symbol;Acc:HGNC:25358]) HSP 1 Score: 141.739 bits (356), Expect = 1.529e-38 Identity = 71/210 (33.81%), Postives = 116/210 (55.24%), Query Frame = 3 Query: 687 NLHSTYEIQYQEFLNQARNE-NIHSNAPNR----------CPVCLEGCKYSIKTSCSHMFCGQCLIGWSNTVNFPGGTTCPVCRTLIKFLLQYFNQDEITSESTEKSDVSNFVKYYNRRYSGMSVSVIDQIRDFPTILRNGIWRIIQ-GDFNFAFRMRIIIVIAGMVLYVLSPLDILPEFLFGIFGFVDDIAAIFLTLSYLNYLFRRSLT 1280 N+H + QE + R + +AP CP+CL + ++T+C H+FCG C+I + ++ G +CP+CR + LL F +D+ +S + + + YNRR+SG S++++I D PT+LR+ + G + FR+RII+ + G Y++SPLD +PE LFGI GF+DD IFL L Y++ ++R +T Sbjct: 47 NVHQNIHPENQELVRVLREQLQTEQDAPAATRQQFYTDMYCPICLHQASFPVETNCGHLFCGACIIAYWRYGSWLGAISCPICRQTVTLLLTVFGEDD---QSQDVLRLHQDINDYNRRFSGQPRSIMERIMDLPTLLRHAFREMFSVGGLFWMFRIRIILCLMGAFFYLISPLDFVPEALFGILGFLDDFFVIFLLLIYISIMYREVIT 253
BLAST of E3 ubiquitin-protein ligase RNF170 vs. Ensembl Human
Match: RNF170 (ring finger protein 170 [Source:HGNC Symbol;Acc:HGNC:25358]) HSP 1 Score: 141.739 bits (356), Expect = 1.529e-38 Identity = 71/210 (33.81%), Postives = 116/210 (55.24%), Query Frame = 3 Query: 687 NLHSTYEIQYQEFLNQARNE-NIHSNAPNR----------CPVCLEGCKYSIKTSCSHMFCGQCLIGWSNTVNFPGGTTCPVCRTLIKFLLQYFNQDEITSESTEKSDVSNFVKYYNRRYSGMSVSVIDQIRDFPTILRNGIWRIIQ-GDFNFAFRMRIIIVIAGMVLYVLSPLDILPEFLFGIFGFVDDIAAIFLTLSYLNYLFRRSLT 1280 N+H + QE + R + +AP CP+CL + ++T+C H+FCG C+I + ++ G +CP+CR + LL F +D+ +S + + + YNRR+SG S++++I D PT+LR+ + G + FR+RII+ + G Y++SPLD +PE LFGI GF+DD IFL L Y++ ++R +T Sbjct: 47 NVHQNIHPENQELVRVLREQLQTEQDAPAATRQQFYTDMYCPICLHQASFPVETNCGHLFCGACIIAYWRYGSWLGAISCPICRQTVTLLLTVFGEDD---QSQDVLRLHQDINDYNRRFSGQPRSIMERIMDLPTLLRHAFREMFSVGGLFWMFRIRIILCLMGAFFYLISPLDFVPEALFGILGFLDDFFVIFLLLIYISIMYREVIT 253
BLAST of E3 ubiquitin-protein ligase RNF170 vs. Ensembl Human
Match: RNF170 (ring finger protein 170 [Source:HGNC Symbol;Acc:HGNC:25358]) HSP 1 Score: 137.887 bits (346), Expect = 4.046e-38 Identity = 64/170 (37.65%), Postives = 104/170 (61.18%), Query Frame = 3 Query: 774 CPVCLEGCKYSIKTSCSHMFCGQCLIGWSNTVNFPGGTTCPVCRTLIKFLLQYFNQDEITSESTEKSDVSNFVKYYNRRYSGMSVSVIDQIRDFPTILRNGIWRIIQ-GDFNFAFRMRIIIVIAGMVLYVLSPLDILPEFLFGIFGFVDDIAAIFLTLSYLNYLFRRSLT 1280 CP+CL + ++T+C H+FCG C+I + ++ G +CP+CR + LL F +D+ +S + + + YNRR+SG S++++I D PT+LR+ + G + FR+RII+ + G Y++SPLD +PE LFGI GF+DD IFL L Y++ ++R +T Sbjct: 3 CPICLHQASFPVETNCGHLFCGACIIAYWRYGSWLGAISCPICRQTVTLLLTVFGEDD---QSQDVLRLHQDINDYNRRFSGQPRSIMERIMDLPTLLRHAFREMFSVGGLFWMFRIRIILCLMGAFFYLISPLDFVPEALFGILGFLDDFFVIFLLLIYISIMYREVIT 169
BLAST of E3 ubiquitin-protein ligase RNF170 vs. Ensembl Human
Match: HMGB2 (high mobility group box 2 [Source:HGNC Symbol;Acc:HGNC:5000]) HSP 1 Score: 69.3218 bits (168), Expect = 4.830e-13 Identity = 37/84 (44.05%), Postives = 51/84 (60.71%), Query Frame = 2 Query: 26 NKPKGAWTAFFFFSDEHRKKIKEENPEYKVGDVAKVLGKMW--EACKDKSKYEEQAKRDKERYNKELEEYKSGTPVSKKTKGAG 271 N PK +AFF F EHR KIK E+P +GD AK LG+MW ++ KDK YE++A + KE+Y K++ Y++ KG G Sbjct: 93 NAPKRPPSAFFLFCSEHRPKIKSEHPGLSIGDTAKKLGEMWSEQSAKDKQPYEQKAAKLKEKYEKDIAAYRAKGKSEAGKKGPG 176 HSP 2 Score: 49.6766 bits (117), Expect = 2.768e-6 Identity = 27/74 (36.49%), Postives = 49/74 (66.22%), Query Frame = 2 Query: 20 DPNKPKGAWTAFFFFSDEHRKKIKEENPEYKV--GDVAKVLGKMWE--ACKDKSKYEEQAKRDKERYNKELEEY 229 DPNKP+G +++ FF R++ K+++P+ V + +K + W+ + K+KSK+E+ AK DK RY++E++ Y Sbjct: 5 DPNKPRGKMSSYAFFVQTCREEHKKKHPDSSVNFAEFSKKCSERWKTMSAKEKSKFEDMAKSDKARYDREMKNY 78
BLAST of E3 ubiquitin-protein ligase RNF170 vs. Ensembl Human
Match: HMGB2 (high mobility group box 2 [Source:HGNC Symbol;Acc:HGNC:5000]) HSP 1 Score: 69.3218 bits (168), Expect = 4.830e-13 Identity = 37/84 (44.05%), Postives = 51/84 (60.71%), Query Frame = 2 Query: 26 NKPKGAWTAFFFFSDEHRKKIKEENPEYKVGDVAKVLGKMW--EACKDKSKYEEQAKRDKERYNKELEEYKSGTPVSKKTKGAG 271 N PK +AFF F EHR KIK E+P +GD AK LG+MW ++ KDK YE++A + KE+Y K++ Y++ KG G Sbjct: 93 NAPKRPPSAFFLFCSEHRPKIKSEHPGLSIGDTAKKLGEMWSEQSAKDKQPYEQKAAKLKEKYEKDIAAYRAKGKSEAGKKGPG 176 HSP 2 Score: 49.6766 bits (117), Expect = 2.768e-6 Identity = 27/74 (36.49%), Postives = 49/74 (66.22%), Query Frame = 2 Query: 20 DPNKPKGAWTAFFFFSDEHRKKIKEENPEYKV--GDVAKVLGKMWE--ACKDKSKYEEQAKRDKERYNKELEEY 229 DPNKP+G +++ FF R++ K+++P+ V + +K + W+ + K+KSK+E+ AK DK RY++E++ Y Sbjct: 5 DPNKPRGKMSSYAFFVQTCREEHKKKHPDSSVNFAEFSKKCSERWKTMSAKEKSKFEDMAKSDKARYDREMKNY 78
BLAST of E3 ubiquitin-protein ligase RNF170 vs. Ensembl Celegans
Match: Y38F1A.2 (pep chromosome:WBcel235:II:12954962:12958018:1 gene:WBGene00012606.1 transcript:Y38F1A.2.1 gene_biotype:protein_coding transcript_biotype:protein_coding gene_symbol:Y38F1A.2) HSP 1 Score: 88.1965 bits (217), Expect = 1.981e-19 Identity = 55/175 (31.43%), Postives = 91/175 (52.00%), Query Frame = 3 Query: 711 QYQEFLNQAR-NENIHSNAPNRCPVCLEGCKYSIKTSCSHMFCGQCLIG-WSNTVNFPGGTTCPVCRTLIKFLLQYFNQDEITSESTEKSDVSNFVKY--YNRRYSGMSVSVIDQIRDFPTILRNGIWRIIQGD-FNFAFRMRIIIVIAGMVLYVLSPLDILPEFLFGIFGFVDD 1220 + + + Q R +E +H ++ + CP+CL + + T C H+FC +C+I W + C +CR+ LL TSE T+ N ++ YNRR+S ++ V+D IRD P ++ I D F +++RI V ++ Y L P D++PE ++GI GF+DD Sbjct: 84 ERNQIITQRRISEALHQSS-HECPICLANASFPVLTDCGHIFCCECIIQYWQQSKAIVTPCDCAMCRSTFYMLLPVHWPTMGTSEETDDHIQENNIRIDDYNRRFS-INRPVLDYIRDIPILIPYLIRNFFNNDIFTLVYQVRIGFVFICVITYFLLPSDMVPESIYGIIGFLDD 256
BLAST of E3 ubiquitin-protein ligase RNF170 vs. Ensembl Celegans
Match: hmg-1.2 (High mobility group protein 1.2 [Source:UniProtKB/Swiss-Prot;Acc:Q09390]) HSP 1 Score: 73.9442 bits (180), Expect = 9.581e-15 Identity = 37/79 (46.84%), Postives = 56/79 (70.89%), Query Frame = 2 Query: 5 KRKIKDPNKPKGAWTAFFFFSDEHRKKIKEENPEYKVGDVAKVLGKMWEACKDKSK--YEEQAKRDKERYNKELEEYKS 235 KR KDP+ PK A +AFFF+S + R +I+ +P++KVG VA+ LGKMW+ ++K YE++A+ DK+RY E+ YK+ Sbjct: 126 KRAKKDPHAPKRALSAFFFYSQDKRPEIQAGHPDWKVGQVAQELGKMWKLVPQETKDMYEQKAQADKDRYADEMRNYKA 204
BLAST of E3 ubiquitin-protein ligase RNF170 vs. Ensembl Celegans
Match: hmg-1.2 (High mobility group protein 1.2 [Source:UniProtKB/Swiss-Prot;Acc:Q09390]) HSP 1 Score: 73.9442 bits (180), Expect = 9.581e-15 Identity = 37/79 (46.84%), Postives = 56/79 (70.89%), Query Frame = 2 Query: 5 KRKIKDPNKPKGAWTAFFFFSDEHRKKIKEENPEYKVGDVAKVLGKMWEACKDKSK--YEEQAKRDKERYNKELEEYKS 235 KR KDP+ PK A +AFFF+S + R +I+ +P++KVG VA+ LGKMW+ ++K YE++A+ DK+RY E+ YK+ Sbjct: 126 KRAKKDPHAPKRALSAFFFYSQDKRPEIQAGHPDWKVGQVAQELGKMWKLVPQETKDMYEQKAQADKDRYADEMRNYKA 204
BLAST of E3 ubiquitin-protein ligase RNF170 vs. Ensembl Celegans
Match: hmg-1.2 (High mobility group protein 1.2 [Source:UniProtKB/Swiss-Prot;Acc:Q09390]) HSP 1 Score: 73.9442 bits (180), Expect = 9.699e-15 Identity = 37/79 (46.84%), Postives = 56/79 (70.89%), Query Frame = 2 Query: 5 KRKIKDPNKPKGAWTAFFFFSDEHRKKIKEENPEYKVGDVAKVLGKMWEACKDKSK--YEEQAKRDKERYNKELEEYKS 235 KR KDP+ PK A +AFFF+S + R +I+ +P++KVG VA+ LGKMW+ ++K YE++A+ DK+RY E+ YK+ Sbjct: 125 KRAKKDPHAPKRALSAFFFYSQDKRPEIQAGHPDWKVGQVAQELGKMWKLVPQETKDMYEQKAQADKDRYADEMRNYKA 203
BLAST of E3 ubiquitin-protein ligase RNF170 vs. Ensembl Celegans
Match: hmg-1.2 (High mobility group protein 1.2 [Source:UniProtKB/Swiss-Prot;Acc:Q09390]) HSP 1 Score: 73.559 bits (179), Expect = 1.020e-14 Identity = 37/79 (46.84%), Postives = 56/79 (70.89%), Query Frame = 2 Query: 5 KRKIKDPNKPKGAWTAFFFFSDEHRKKIKEENPEYKVGDVAKVLGKMWEACKDKSK--YEEQAKRDKERYNKELEEYKS 235 KR KDP+ PK A +AFFF+S + R +I+ +P++KVG VA+ LGKMW+ ++K YE++A+ DK+RY E+ YK+ Sbjct: 124 KRAKKDPHAPKRALSAFFFYSQDKRPEIQAGHPDWKVGQVAQELGKMWKLVPQETKDMYEQKAQADKDRYADEMRNYKA 202
BLAST of E3 ubiquitin-protein ligase RNF170 vs. Ensembl Fly
Match: Dsp1 (gene:FBgn0278608 transcript:FBtr0089259) HSP 1 Score: 81.6481 bits (200), Expect = 1.477e-16 Identity = 39/84 (46.43%), Postives = 58/84 (69.05%), Query Frame = 2 Query: 5 KRKIKDPNKPKGAWTAFFFFSDEHRKKIKEENPEYKVGDVAKVLGKMWEAC--KDKSKYEEQAKRDKERYNKELEEYKSGTPVS 250 +++IKDPN PK + +AFF+F ++ R K+K NPE+ VGD+AK LG+ W + K KYE A+RDK RY +E+ EYK+ ++ Sbjct: 254 RKQIKDPNAPKRSLSAFFWFCNDERNKVKALNPEFGVGDIAKELGRKWSDVDPEVKQKYESMAERDKARYEREMTEYKTSGKIA 337
BLAST of E3 ubiquitin-protein ligase RNF170 vs. Ensembl Fly
Match: Dsp1 (gene:FBgn0278608 transcript:FBtr0089260) HSP 1 Score: 81.6481 bits (200), Expect = 1.477e-16 Identity = 39/84 (46.43%), Postives = 58/84 (69.05%), Query Frame = 2 Query: 5 KRKIKDPNKPKGAWTAFFFFSDEHRKKIKEENPEYKVGDVAKVLGKMWEAC--KDKSKYEEQAKRDKERYNKELEEYKSGTPVS 250 +++IKDPN PK + +AFF+F ++ R K+K NPE+ VGD+AK LG+ W + K KYE A+RDK RY +E+ EYK+ ++ Sbjct: 254 RKQIKDPNAPKRSLSAFFWFCNDERNKVKALNPEFGVGDIAKELGRKWSDVDPEVKQKYESMAERDKARYEREMTEYKTSGKIA 337
BLAST of E3 ubiquitin-protein ligase RNF170 vs. Ensembl Fly
Match: Dsp1 (gene:FBgn0278608 transcript:FBtr0089261) HSP 1 Score: 81.6481 bits (200), Expect = 1.477e-16 Identity = 39/84 (46.43%), Postives = 58/84 (69.05%), Query Frame = 2 Query: 5 KRKIKDPNKPKGAWTAFFFFSDEHRKKIKEENPEYKVGDVAKVLGKMWEAC--KDKSKYEEQAKRDKERYNKELEEYKSGTPVS 250 +++IKDPN PK + +AFF+F ++ R K+K NPE+ VGD+AK LG+ W + K KYE A+RDK RY +E+ EYK+ ++ Sbjct: 254 RKQIKDPNAPKRSLSAFFWFCNDERNKVKALNPEFGVGDIAKELGRKWSDVDPEVKQKYESMAERDKARYEREMTEYKTSGKIA 337
BLAST of E3 ubiquitin-protein ligase RNF170 vs. Ensembl Fly
Match: Dsp1 (gene:FBgn0278608 transcript:FBtr0089262) HSP 1 Score: 81.6481 bits (200), Expect = 1.487e-16 Identity = 39/84 (46.43%), Postives = 58/84 (69.05%), Query Frame = 2 Query: 5 KRKIKDPNKPKGAWTAFFFFSDEHRKKIKEENPEYKVGDVAKVLGKMWEAC--KDKSKYEEQAKRDKERYNKELEEYKSGTPVS 250 +++IKDPN PK + +AFF+F ++ R K+K NPE+ VGD+AK LG+ W + K KYE A+RDK RY +E+ EYK+ ++ Sbjct: 255 RKQIKDPNAPKRSLSAFFWFCNDERNKVKALNPEFGVGDIAKELGRKWSDVDPEVKQKYESMAERDKARYEREMTEYKTSGKIA 338
BLAST of E3 ubiquitin-protein ligase RNF170 vs. Ensembl Fly
Match: Dsp1 (gene:FBgn0278608 transcript:FBtr0339766) HSP 1 Score: 81.6481 bits (200), Expect = 1.487e-16 Identity = 39/84 (46.43%), Postives = 58/84 (69.05%), Query Frame = 2 Query: 5 KRKIKDPNKPKGAWTAFFFFSDEHRKKIKEENPEYKVGDVAKVLGKMWEAC--KDKSKYEEQAKRDKERYNKELEEYKSGTPVS 250 +++IKDPN PK + +AFF+F ++ R K+K NPE+ VGD+AK LG+ W + K KYE A+RDK RY +E+ EYK+ ++ Sbjct: 255 RKQIKDPNAPKRSLSAFFWFCNDERNKVKALNPEFGVGDIAKELGRKWSDVDPEVKQKYESMAERDKARYEREMTEYKTSGKIA 338
BLAST of E3 ubiquitin-protein ligase RNF170 vs. Ensembl Zebrafish
Match: rnf170 (ring finger protein 170 [Source:NCBI gene;Acc:406612]) HSP 1 Score: 132.494 bits (332), Expect = 3.402e-35 Identity = 64/213 (30.05%), Postives = 116/213 (54.46%), Query Frame = 3 Query: 675 NSSYNLHSTYEIQYQEFLNQARNENIHSNAPNR------CPVCLEGCKYSIKTSCSHMFCGQCLIGWSNTVNFPGGTTCPVCRTLIKFLLQYFNQDEITSEST----EKSDVSNFVKYYNRRYSGMSVSVIDQIRDFPTILRNGIWRIIQ-GDFNFAFRMRIIIVIAGMVLYVLSPLDILPEFLFGIFGFVDDIAAIFLTLSYLNYLFRRSLT 1280 + +H + + + Q + E + S + ++ CPVCL+ ++T+C H+FCG C+I + + G +CP+CR ++ L F E ++ + E + + + YNRR+SG S++D++RD PT+LR+ + G + FR+RI++ + G + Y++SPLD LPE + G+ GF+DD I L Y++ ++R +T Sbjct: 49 SEQQRIHPESQERVRVVREQLQAEQVSSESRHQFYSDMSCPVCLQQAVLPVETNCGHLFCGSCIIAYWRYGTWLGAISCPICRQMVTLLFPLFQDSEQSAVAADSLVEPTLILTDISDYNRRFSGQPRSLLDRLRDVPTLLRHAFREMFSVGGLFWMFRVRILLCVCGALAYLVSPLDFLPEGVLGLLGFLDDFFVILLLFIYISIMYREVVT 261
BLAST of E3 ubiquitin-protein ligase RNF170 vs. Ensembl Zebrafish
Match: rnf170 (ring finger protein 170 [Source:NCBI gene;Acc:406612]) HSP 1 Score: 132.494 bits (332), Expect = 3.402e-35 Identity = 64/213 (30.05%), Postives = 116/213 (54.46%), Query Frame = 3 Query: 675 NSSYNLHSTYEIQYQEFLNQARNENIHSNAPNR------CPVCLEGCKYSIKTSCSHMFCGQCLIGWSNTVNFPGGTTCPVCRTLIKFLLQYFNQDEITSEST----EKSDVSNFVKYYNRRYSGMSVSVIDQIRDFPTILRNGIWRIIQ-GDFNFAFRMRIIIVIAGMVLYVLSPLDILPEFLFGIFGFVDDIAAIFLTLSYLNYLFRRSLT 1280 + +H + + + Q + E + S + ++ CPVCL+ ++T+C H+FCG C+I + + G +CP+CR ++ L F E ++ + E + + + YNRR+SG S++D++RD PT+LR+ + G + FR+RI++ + G + Y++SPLD LPE + G+ GF+DD I L Y++ ++R +T Sbjct: 49 SEQQRIHPESQERVRVVREQLQAEQVSSESRHQFYSDMSCPVCLQQAVLPVETNCGHLFCGSCIIAYWRYGTWLGAISCPICRQMVTLLFPLFQDSEQSAVAADSLVEPTLILTDISDYNRRFSGQPRSLLDRLRDVPTLLRHAFREMFSVGGLFWMFRVRILLCVCGALAYLVSPLDFLPEGVLGLLGFLDDFFVILLLFIYISIMYREVVT 261
BLAST of E3 ubiquitin-protein ligase RNF170 vs. Ensembl Zebrafish
Match: si:dkey-183n20.15 (si:dkey-183n20.15 [Source:ZFIN;Acc:ZDB-GENE-041001-160]) HSP 1 Score: 85.8853 bits (211), Expect = 8.773e-19 Identity = 55/201 (27.36%), Postives = 91/201 (45.27%), Query Frame = 3 Query: 651 LISLINRFNSSYNLHSTYEIQYQEFLNQARNENIHSNAPNRCPVCLEGCKYSIKTSCSHMFCGQCLIGWSNTVNFPGGTTCPVCRTLIKFLLQYFNQDEITSESTEKSDVSNFVKYYNRRYSGMSVSVIDQIRDFP---TILRNGIWRIIQGDFNFAFRMRIIIVIAGMVLYVLSPLDILPEFLFGIFGFVDDIAAIFLTL 1244 L+ I +N H + A + ++H CPVCL+ Y ++T+C H+FC CLI + ++ +CP+CR +K + F++++ + E V V+ YN+RYSG V D + D P +L G+ + G + F +R+ + G + L LP L G +DD +FL L Sbjct: 13 LLPKIRSQGCPHNAHVNNREDLPKMWLPAGSRDVH------CPVCLQMATYPVETNCGHLFCAPCLISYWKHCSWLDAISCPLCRQTVKKMCHLFSENKTDCKERE---VLRHVRDYNKRYSGAPRQVKDYLCDAPLFLLVLVRGLGNM--GGLVWLFLLRVAVCGFGAAMS----LAALPGPLSSALGILDDFVVVFLLL 198
BLAST of E3 ubiquitin-protein ligase RNF170 vs. Ensembl Zebrafish
Match: si:dkey-183n20.15 (si:dkey-183n20.15 [Source:ZFIN;Acc:ZDB-GENE-041001-160]) HSP 1 Score: 85.8853 bits (211), Expect = 8.773e-19 Identity = 55/201 (27.36%), Postives = 91/201 (45.27%), Query Frame = 3 Query: 651 LISLINRFNSSYNLHSTYEIQYQEFLNQARNENIHSNAPNRCPVCLEGCKYSIKTSCSHMFCGQCLIGWSNTVNFPGGTTCPVCRTLIKFLLQYFNQDEITSESTEKSDVSNFVKYYNRRYSGMSVSVIDQIRDFP---TILRNGIWRIIQGDFNFAFRMRIIIVIAGMVLYVLSPLDILPEFLFGIFGFVDDIAAIFLTL 1244 L+ I +N H + A + ++H CPVCL+ Y ++T+C H+FC CLI + ++ +CP+CR +K + F++++ + E V V+ YN+RYSG V D + D P +L G+ + G + F +R+ + G + L LP L G +DD +FL L Sbjct: 13 LLPKIRSQGCPHNAHVNNREDLPKMWLPAGSRDVH------CPVCLQMATYPVETNCGHLFCAPCLISYWKHCSWLDAISCPLCRQTVKKMCHLFSENKTDCKERE---VLRHVRDYNKRYSGAPRQVKDYLCDAPLFLLVLVRGLGNM--GGLVWLFLLRVAVCGFGAAMS----LAALPGPLSSALGILDDFVVVFLLL 198
BLAST of E3 ubiquitin-protein ligase RNF170 vs. Ensembl Zebrafish
Match: hmgb2b (high mobility group box 2b [Source:ZFIN;Acc:ZDB-GENE-040912-122]) HSP 1 Score: 74.7146 bits (182), Expect = 5.497e-15 Identity = 36/88 (40.91%), Postives = 59/88 (67.05%), Query Frame = 2 Query: 8 RKIKDPNKPKGAWTAFFFFSDEHRKKIKEENPEYKVGDVAKVLGKMW--EACKDKSKYEEQAKRDKERYNKELEEYKSGTPVSKKTKG 265 RK KDPN PK +AFF F E+R +K E+P +G++AK LG++W ++ KD++ +E++A + +E+Y KE+ Y++G SK+ G Sbjct: 89 RKKKDPNAPKRPPSAFFVFCSEYRPTVKSEHPNLTIGEIAKKLGELWSKQSSKDRAPFEQKAGKLREKYEKEVAAYRAGGGASKRGPG 176
BLAST of E3 ubiquitin-protein ligase RNF170 vs. Ensembl Xenopus
Match: pcmtd2 (protein-L-isoaspartate (D-aspartate) O-methyltransferase domain containing 2 [Source:Xenbase;Acc:XB-GENE-947888]) HSP 1 Score: 142.124 bits (357), Expect = 1.109e-38 Identity = 70/213 (32.86%), Postives = 118/213 (55.40%), Query Frame = 3 Query: 675 NSSYNLHSTYEIQYQEFLNQARNENIHSNAPN-------RCPVCLEGCKYSIKTSCSHMFCGQCLIGWSNTVNFPGGTTCPVCRTLIKFLLQYFNQDEITSESTEKSDVSNFVKY---YNRRYSGMSVSVIDQIRDFPTILRNGIWRIIQ-GDFNFAFRMRIIIVIAGMVLYVLSPLDILPEFLFGIFGFVDDIAAIFLTLSYLNYLFRRSLT 1280 N N+H + + + Q +NE P CPVCL+ + ++T+C H+FCG C+I + ++ G CP+CR + + F ++TE+ D N ++ YNRR+SG S++D+I D PT+LR+ + G + FR+RI++ + G + Y++SPLDI+PE +FG+ GF+DD +FL L Y++ ++R +T Sbjct: 47 NDEQNIHPENQDRVRAVREQLQNEQETPPPPRPQFYSDMTCPVCLQQATFPVETNCGHLFCGSCIIAYWRYGSWLGAINCPICRQTVTLIFPLF-------QATEQEDSQNILREAIGYNRRFSGQPRSLMDRIMDLPTLLRHAFREMFSVGGLFWMFRIRIVLCLLGALFYLVSPLDIIPEAVFGLLGFLDDFFVLFLLLIYISIMYREVVT 252
BLAST of E3 ubiquitin-protein ligase RNF170 vs. Ensembl Xenopus
Match: ENSXETT00000034170.1 (uncharacterized loc100145035 [Source:NCBI gene;Acc:100145035]) HSP 1 Score: 113.62 bits (283), Expect = 2.173e-28 Identity = 62/208 (29.81%), Postives = 110/208 (52.88%), Query Frame = 3 Query: 669 RFNSSYNLHSTYEIQYQEFLNQARNENI------HSNAPNRCPVCLEGCKYSIKTSCSHMFCGQCLIGWSNTVNFPGGTTCPVCRTLIKFLLQYFNQDEITSESTEKSDVSNFVKYYNRRYSGMSVSVIDQIRDFPTILRNGIWRI-IQGDFNFAFRMRIIIVIAGMVLYVLSPLDILPEFLFGIFGFVDDIAAIFLTLSYLNYLFRR 1271 RF+ Y L QE L+ N++ H + CPVCL+ ++T+C H+FCG CL+ + + G +CP+CR + L F +++ S D+ + +++YN R+SG V D + D P++L G+ RI G + F +RI++ + G+V+ +P D++P+ + GI +DD+ +FL LS + +F++ Sbjct: 13 RFSCGYKLDMNSPKPEQEKLSLTNNKDSYKCRQSHFDNDLNCPVCLQTATMPVETNCGHLFCGSCLMTYWKHDPWLGAMSCPLCRQKVVLLYNDFWENQADKLS---RDIVHDIRHYNNRFSGKPRPVTDYLYDMPSLLHLGLRRIFTMGGLVWVFCLRILVCLFGVVVCFSTPFDVIPDPMCGILSIIDDLVVVFLLLSCIINIFQQ 217
BLAST of E3 ubiquitin-protein ligase RNF170 vs. Ensembl Xenopus
Match: ENSXETT00000034163.1 (uncharacterized loc100145035 [Source:NCBI gene;Acc:100145035]) HSP 1 Score: 111.309 bits (277), Expect = 1.183e-27 Identity = 61/207 (29.47%), Postives = 109/207 (52.66%), Query Frame = 3 Query: 672 FNSSYNLHSTYEIQYQEFLNQARNENI------HSNAPNRCPVCLEGCKYSIKTSCSHMFCGQCLIGWSNTVNFPGGTTCPVCRTLIKFLLQYFNQDEITSESTEKSDVSNFVKYYNRRYSGMSVSVIDQIRDFPTILRNGIWRI-IQGDFNFAFRMRIIIVIAGMVLYVLSPLDILPEFLFGIFGFVDDIAAIFLTLSYLNYLFRR 1271 F+ Y L QE L+ N++ H + CPVCL+ ++T+C H+FCG CL+ + + G +CP+CR + L F +++ S D+ + +++YN R+SG V D + D P++L G+ RI G + F +RI++ + G+V+ +P D++P+ + GI +DD+ +FL LS + +F++ Sbjct: 3 FSCGYKLDMNSPKPEQEKLSLTNNKDSYKCRQSHFDNDLNCPVCLQTATMPVETNCGHLFCGSCLMTYWKHDPWLGAMSCPLCRQKVVLLYNDFWENQADKLS---RDIVHDIRHYNNRFSGKPRPVTDYLYDMPSLLHLGLRRIFTMGGLVWVFCLRILVCLFGVVVCFSTPFDVIPDPMCGILSIIDDLVVVFLLLSCIINIFQQ 206
BLAST of E3 ubiquitin-protein ligase RNF170 vs. Ensembl Xenopus
Match: hmgb2 (high mobility group box 2 [Source:NCBI gene;Acc:394499]) HSP 1 Score: 72.4034 bits (176), Expect = 4.597e-14 Identity = 36/74 (48.65%), Postives = 49/74 (66.22%), Query Frame = 2 Query: 20 DPNKPKGAWTAFFFFSDEHRKKIKEENPEYKVGDVAKVLGKMW--EACKDKSKYEEQAKRDKERYNKELEEYKS 235 DPN PK +AFF F EHR +IK E+P +GD AK LG+MW + KDK YE++A + KE+Y K++ YK+ Sbjct: 92 DPNAPKRPPSAFFLFCSEHRPQIKSESPGLSIGDTAKKLGEMWSEQTPKDKLPYEQKAAKLKEKYEKDVAAYKA 165 HSP 2 Score: 47.7506 bits (112), Expect = 9.802e-6 Identity = 27/74 (36.49%), Postives = 48/74 (64.86%), Query Frame = 2 Query: 20 DPNKPKGAWTAFFFFSDEHRKKIKEENPEYKV--GDVAKVLGKMWE--ACKDKSKYEEQAKRDKERYNKELEEY 229 DPNKP+G +++ +F R++ K+++P+ V + +K + W+ + K+KSK+EE AK DK RY +E++ Y Sbjct: 5 DPNKPRGKMSSYAYFVQTCREEHKKKHPDSSVNFAEFSKKCSERWKTMSAKEKSKFEEMAKNDKVRYEREMKTY 78
BLAST of E3 ubiquitin-protein ligase RNF170 vs. Ensembl Xenopus
Match: cep170b (centrosomal protein 170B [Source:Xenbase;Acc:XB-GENE-5943417]) HSP 1 Score: 71.2478 bits (173), Expect = 1.150e-13 Identity = 38/80 (47.50%), Postives = 51/80 (63.75%), Query Frame = 2 Query: 2 NKRKIKDPNKPKGAWTAFFFFSDEHRKKIKEENPEYKVGDVAKVLGKMW--EACKDKSKYEEQAKRDKERYNKELEEYKS 235 K+K KDPN PK +AFF F E R KIK E+P +GD+AK LG+MW A DK YE +A + KE+Y K++ Y++ Sbjct: 85 TKKKFKDPNAPKRPPSAFFLFCSEFRPKIKGEHPGSTIGDIAKKLGEMWNNTATDDKLPYERKAAKLKEKYEKDVAAYRA 164
BLAST of E3 ubiquitin-protein ligase RNF170 vs. Ensembl Mouse
Match: Rnf170 (ring finger protein 170 [Source:MGI Symbol;Acc:MGI:1924983]) HSP 1 Score: 139.813 bits (351), Expect = 3.521e-38 Identity = 75/218 (34.40%), Postives = 121/218 (55.50%), Query Frame = 3 Query: 657 SLINRFNSSYNLHSTYEIQYQEFLNQARNENIHSNAPNR--------CPVCLEGCKYSIKTSCSHMFCGQCLIGWSNTVNFPGGTTCPVCRTLIKFLLQYFNQDEITSESTE-KSDVSNFVKYYNRRYSGMSVSVIDQIRDFPTILRNGIWRIIQ-GDFNFAFRMRIIIVIAGMVLYVLSPLDILPEFLFGIFGFVDDIAAIFLTLSYLNYLFRRSLT 1280 S I R N N+H + + Q + E AP R CP+CL + ++T+C H+FCG C+I + ++ G +CP+CR + LL F +D+ + + + DV++ YNRR+SG S++++I D PT+LR+ + G + FR+RI++ + G Y++SPLD +PE LFGI GF+DD IFL L Y++ ++R +T Sbjct: 23 SWIQR-NVQQNIHPENQELVRVLREQFQTEQ-DVPAPARQQFYTEMYCPICLHQASFPVETNCGHLFCGSCIIAYWRYGSWLGAISCPICRQTVTLLLTVFGEDDQSQDVIRLRQDVND----YNRRFSGQPRSIMERIMDLPTLLRHAFREVFSVGGLFWMFRIRIMLCLMGAFFYLISPLDFVPEALFGILGFLDDFFVIFLLLIYISIMYREVIT 234
BLAST of E3 ubiquitin-protein ligase RNF170 vs. Ensembl Mouse
Match: Rnf170 (ring finger protein 170 [Source:MGI Symbol;Acc:MGI:1924983]) HSP 1 Score: 139.043 bits (349), Expect = 2.149e-37 Identity = 72/212 (33.96%), Postives = 118/212 (55.66%), Query Frame = 3 Query: 675 NSSYNLHSTYEIQYQEFLNQARNENIHSNAPNR--------CPVCLEGCKYSIKTSCSHMFCGQCLIGWSNTVNFPGGTTCPVCRTLIKFLLQYFNQDEITSESTE-KSDVSNFVKYYNRRYSGMSVSVIDQIRDFPTILRNGIWRIIQ-GDFNFAFRMRIIIVIAGMVLYVLSPLDILPEFLFGIFGFVDDIAAIFLTLSYLNYLFRRSLT 1280 N N+H + + Q + E AP R CP+CL + ++T+C H+FCG C+I + ++ G +CP+CR + LL F +D+ + + + DV++ YNRR+SG S++++I D PT+LR+ + G + FR+RI++ + G Y++SPLD +PE LFGI GF+DD IFL L Y++ ++R +T Sbjct: 75 NVQQNIHPENQELVRVLREQFQTEQ-DVPAPARQQFYTEMYCPICLHQASFPVETNCGHLFCGSCIIAYWRYGSWLGAISCPICRQTVTLLLTVFGEDDQSQDVIRLRQDVND----YNRRFSGQPRSIMERIMDLPTLLRHAFREVFSVGGLFWMFRIRIMLCLMGAFFYLISPLDFVPEALFGILGFLDDFFVIFLLLIYISIMYREVIT 281
BLAST of E3 ubiquitin-protein ligase RNF170 vs. Ensembl Mouse
Match: Rnf170 (ring finger protein 170 [Source:MGI Symbol;Acc:MGI:1924983]) HSP 1 Score: 107.457 bits (267), Expect = 3.595e-26 Identity = 48/139 (34.53%), Postives = 84/139 (60.43%), Query Frame = 3 Query: 774 CPVCLEGCKYSIKTSCSHMFCGQCLIGWSNTVNFPGGTTCPVCRTLIKFLLQYFNQDEITSESTE-KSDVSNFVKYYNRRYSGMSVSVIDQIRDFPTILRNGIWRIIQ-GDFNFAFRMRIIIVIAGMVLYVLSPLDILP 1184 CP+CL + ++T+C H+FCG C+I + ++ G +CP+CR + LL F +D+ + + + DV++ YNRR+SG S++++I D PT+LR+ + G + FR+RI++ + G Y++SPLD +P Sbjct: 115 CPICLHQASFPVETNCGHLFCGSCIIAYWRYGSWLGAISCPICRQTVTLLLTVFGEDDQSQDVIRLRQDVND----YNRRFSGQPRSIMERIMDLPTLLRHAFREVFSVGGLFWMFRIRIMLCLMGAFFYLISPLDFVP 249
BLAST of E3 ubiquitin-protein ligase RNF170 vs. Ensembl Mouse
Match: Hmgb1 (high mobility group box 1 [Source:MGI Symbol;Acc:MGI:96113]) HSP 1 Score: 67.0106 bits (162), Expect = 2.674e-12 Identity = 39/80 (48.75%), Postives = 53/80 (66.25%), Query Frame = 2 Query: 2 NKRKIKDPNKPKGAWTAFFFFSDEHRKKIKEENPEYKVGDVAKVLGKMW--EACKDKSKYEEQAKRDKERYNKELEEYKS 235 K+K KDPN PK +AFF F E+R KIK E+P +GDVAK LG+MW A DK YE++A + KE+Y K++ Y++ Sbjct: 99 TKKKFKDPNAPKRPPSAFFLFCSEYRPKIKGEHPGLSIGDVAKKLGEMWNNTAADDKQPYEKKAAKLKEKYEKDIAAYRA 178
BLAST of E3 ubiquitin-protein ligase RNF170 vs. Ensembl Mouse
Match: Hmgb1 (high mobility group box 1 [Source:MGI Symbol;Acc:MGI:96113]) HSP 1 Score: 66.6254 bits (161), Expect = 3.942e-12 Identity = 39/80 (48.75%), Postives = 53/80 (66.25%), Query Frame = 2 Query: 2 NKRKIKDPNKPKGAWTAFFFFSDEHRKKIKEENPEYKVGDVAKVLGKMW--EACKDKSKYEEQAKRDKERYNKELEEYKS 235 K+K KDPN PK +AFF F E+R KIK E+P +GDVAK LG+MW A DK YE++A + KE+Y K++ Y++ Sbjct: 85 TKKKFKDPNAPKRPPSAFFLFCSEYRPKIKGEHPGLSIGDVAKKLGEMWNNTAADDKQPYEKKAAKLKEKYEKDIAAYRA 164
BLAST of E3 ubiquitin-protein ligase RNF170 vs. UniProt/SwissProt
Match: sp|Q28DS3|RN170_XENTR (E3 ubiquitin-protein ligase RNF170 OS=Xenopus tropicalis OX=8364 GN=rnf170 PE=2 SV=1) HSP 1 Score: 142.124 bits (357), Expect = 5.874e-38 Identity = 70/213 (32.86%), Postives = 118/213 (55.40%), Query Frame = 3 Query: 675 NSSYNLHSTYEIQYQEFLNQARNENIHSNAPN-------RCPVCLEGCKYSIKTSCSHMFCGQCLIGWSNTVNFPGGTTCPVCRTLIKFLLQYFNQDEITSESTEKSDVSNFVKY---YNRRYSGMSVSVIDQIRDFPTILRNGIWRIIQ-GDFNFAFRMRIIIVIAGMVLYVLSPLDILPEFLFGIFGFVDDIAAIFLTLSYLNYLFRRSLT 1280 N N+H + + + Q +NE P CPVCL+ + ++T+C H+FCG C+I + ++ G CP+CR + + F ++TE+ D N ++ YNRR+SG S++D+I D PT+LR+ + G + FR+RI++ + G + Y++SPLDI+PE +FG+ GF+DD +FL L Y++ ++R +T Sbjct: 47 NDEQNIHPENQDRVRAVREQLQNEQETPPPPRPQFYSDMTCPVCLQQATFPVETNCGHLFCGSCIIAYWRYGSWLGAINCPICRQTVTLIFPLF-------QATEQEDSQNILREAIGYNRRFSGQPRSLMDRIMDLPTLLRHAFREMFSVGGLFWMFRIRIVLCLLGALFYLVSPLDIIPEAVFGLLGFLDDFFVLFLLLIYISIMYREVVT 252
BLAST of E3 ubiquitin-protein ligase RNF170 vs. UniProt/SwissProt
Match: sp|Q96K19|RN170_HUMAN (E3 ubiquitin-protein ligase RNF170 OS=Homo sapiens OX=9606 GN=RNF170 PE=1 SV=2) HSP 1 Score: 141.739 bits (356), Expect = 7.342e-38 Identity = 71/210 (33.81%), Postives = 116/210 (55.24%), Query Frame = 3 Query: 687 NLHSTYEIQYQEFLNQARNE-NIHSNAPNR----------CPVCLEGCKYSIKTSCSHMFCGQCLIGWSNTVNFPGGTTCPVCRTLIKFLLQYFNQDEITSESTEKSDVSNFVKYYNRRYSGMSVSVIDQIRDFPTILRNGIWRIIQ-GDFNFAFRMRIIIVIAGMVLYVLSPLDILPEFLFGIFGFVDDIAAIFLTLSYLNYLFRRSLT 1280 N+H + QE + R + +AP CP+CL + ++T+C H+FCG C+I + ++ G +CP+CR + LL F +D+ +S + + + YNRR+SG S++++I D PT+LR+ + G + FR+RII+ + G Y++SPLD +PE LFGI GF+DD IFL L Y++ ++R +T Sbjct: 47 NVHQNIHPENQELVRVLREQLQTEQDAPAATRQQFYTDMYCPICLHQASFPVETNCGHLFCGACIIAYWRYGSWLGAISCPICRQTVTLLLTVFGEDD---QSQDVLRLHQDINDYNRRFSGQPRSIMERIMDLPTLLRHAFREMFSVGGLFWMFRIRIILCLMGAFFYLISPLDFVPEALFGILGFLDDFFVIFLLLIYISIMYREVIT 253
BLAST of E3 ubiquitin-protein ligase RNF170 vs. UniProt/SwissProt
Match: sp|F1MK05|RN170_BOVIN (E3 ubiquitin-protein ligase RNF170 OS=Bos taurus OX=9913 GN=RNF170 PE=3 SV=2) HSP 1 Score: 138.272 bits (347), Expect = 1.272e-36 Identity = 71/213 (33.33%), Postives = 116/213 (54.46%), Query Frame = 3 Query: 681 SYNLHSTYEIQYQEFLNQARNE-NIHSNAPNR----------CPVCLEGCKYSIKTSCSHMFCGQCLIGWSNTVNFPGGTTCPVCRTLIKFLLQYFNQDEITSESTE-KSDVSNFVKYYNRRYSGMSVSVIDQIRDFPTILRNGIWRIIQ-GDFNFAFRMRIIIVIAGMVLYVLSPLDILPEFLFGIFGFVDDIAAIFLTLSYLNYLFRRSLT 1280 S N H + QE + R + +AP CP+CL ++T+C H+FCG C++ + ++ G +CP+CR + LL F +++ + + D+S+ YNRR+SG S++++I D PT+LR+ + G + FR+RII+ + G Y++SPLD +PE LFGI GF+DD IFL L Y++ ++R +T Sbjct: 46 SRNAHQNIHPENQELVRVLREQLQTEQDAPAAARQQFYTDMYCPICLHQASLPVETNCGHLFCGTCIVAYWRYGSWLGAISCPICRQTVTLLLPVFGENDQSQDVVSLHQDISD----YNRRFSGQPRSIMERIMDLPTLLRHAFREMFSVGGLFWMFRIRIILCLMGAFFYLISPLDFVPEALFGILGFLDDFFVIFLLLIYISIMYREVIT 254
BLAST of E3 ubiquitin-protein ligase RNF170 vs. UniProt/SwissProt
Match: sp|Q8CBG9|RN170_MOUSE (E3 ubiquitin-protein ligase RNF170 OS=Mus musculus OX=10090 GN=Rnf170 PE=1 SV=1) HSP 1 Score: 139.043 bits (349), Expect = 1.503e-36 Identity = 72/212 (33.96%), Postives = 118/212 (55.66%), Query Frame = 3 Query: 675 NSSYNLHSTYEIQYQEFLNQARNENIHSNAPNR--------CPVCLEGCKYSIKTSCSHMFCGQCLIGWSNTVNFPGGTTCPVCRTLIKFLLQYFNQDEITSESTE-KSDVSNFVKYYNRRYSGMSVSVIDQIRDFPTILRNGIWRIIQ-GDFNFAFRMRIIIVIAGMVLYVLSPLDILPEFLFGIFGFVDDIAAIFLTLSYLNYLFRRSLT 1280 N N+H + + Q + E AP R CP+CL + ++T+C H+FCG C+I + ++ G +CP+CR + LL F +D+ + + + DV++ YNRR+SG S++++I D PT+LR+ + G + FR+RI++ + G Y++SPLD +PE LFGI GF+DD IFL L Y++ ++R +T Sbjct: 75 NVQQNIHPENQELVRVLREQFQTEQ-DVPAPARQQFYTEMYCPICLHQASFPVETNCGHLFCGSCIIAYWRYGSWLGAISCPICRQTVTLLLTVFGEDDQSQDVIRLRQDVND----YNRRFSGQPRSIMERIMDLPTLLRHAFREVFSVGGLFWMFRIRIMLCLMGAFFYLISPLDFVPEALFGILGFLDDFFVIFLLLIYISIMYREVIT 281
BLAST of E3 ubiquitin-protein ligase RNF170 vs. UniProt/SwissProt
Match: sp|Q7SZN2|RN170_DANRE (E3 ubiquitin-protein ligase RNF170 OS=Danio rerio OX=7955 GN=rnf170 PE=2 SV=1) HSP 1 Score: 132.494 bits (332), Expect = 2.905e-34 Identity = 64/213 (30.05%), Postives = 115/213 (53.99%), Query Frame = 3 Query: 675 NSSYNLHSTYEIQYQEFLNQARNENIHSNAPNR------CPVCLEGCKYSIKTSCSHMFCGQCLIGWSNTVNFPGGTTCPVCRTLIKFLLQYFNQDEITS----ESTEKSDVSNFVKYYNRRYSGMSVSVIDQIRDFPTILRNGIWRIIQ-GDFNFAFRMRIIIVIAGMVLYVLSPLDILPEFLFGIFGFVDDIAAIFLTLSYLNYLFRRSLT 1280 + +H + + + Q + E + S + ++ CPVCL+ ++T+C H+FCG C+I + + G +CP+CR ++ L F E ++ E + + + YNRR+SG S++D++RD PT+LR+ + G + FR+RI++ + G + Y++SPLD LPE + G+ GF+DD I L Y++ ++R +T Sbjct: 49 SEQQRIHPESQERVRVVREQLQAEQVSSESRHQFYSDMSCPVCLQQAVLPVETNCGHLFCGSCIIAYWRYGTWLGAISCPICRQMVTLLFPLFQDSEQSAVAADSPVEPTLILTDISDYNRRFSGQPRSLLDRLRDVPTLLRHAFREMFSVGGLFWMFRVRILLCVCGALAYLVSPLDFLPEGVLGLLGFLDDFFVILLLFIYISIMYREVVT 261
BLAST of E3 ubiquitin-protein ligase RNF170 vs. TrEMBL
Match: I1ZIJ2 (High mobility group-1 OS=Schmidtea mediterranea OX=79327 PE=2 SV=1) HSP 1 Score: 198.364 bits (503), Expect = 8.485e-58 Identity = 97/97 (100.00%), Postives = 97/97 (100.00%), Query Frame = 2 Query: 2 NKRKIKDPNKPKGAWTAFFFFSDEHRKKIKEENPEYKVGDVAKVLGKMWEACKDKSKYEEQAKRDKERYNKELEEYKSGTPVSKKTKGAGDQVNGNH 292 NKRKIKDPNKPKGAWTAFFFFSDEHRKKIKEENPEYKVGDVAKVLGKMWEACKDKSKYEEQAKRDKERYNKELEEYKSGTPVSKKTKGAGDQVNGNH Sbjct: 83 NKRKIKDPNKPKGAWTAFFFFSDEHRKKIKEENPEYKVGDVAKVLGKMWEACKDKSKYEEQAKRDKERYNKELEEYKSGTPVSKKTKGAGDQVNGNH 179
BLAST of E3 ubiquitin-protein ligase RNF170 vs. TrEMBL
Match: A0A0R3UNK5 (RING-type domain-containing protein OS=Mesocestoides corti OX=53468 GN=MCOS_LOCUS9383 PE=4 SV=1) HSP 1 Score: 147.517 bits (371), Expect = 1.478e-37 Identity = 70/178 (39.33%), Postives = 108/178 (60.67%), Query Frame = 3 Query: 756 SNAPNRCPVCLEGCKYSIKTSCSHMFCGQCLIGWSNTVNFPGGTTCPVCRTLIKFLLQYFNQDEITSEST-EKSDVSNFVKYYNRRYSGMSVSVIDQIRDFPTILRNGIWRIIQGD-FNFAFRMRIIIVIAGMVLYVLSPLDILPEFLFGIFGFVDDIAAIFLTLSYLNYLFRRSLTT 1283 + AP+ CP+CLEG + I+T+C H FCG C + + CPVCR ++FL++ F +EI +++T E+SDV + + +NRRYSG VS +DQ+RD P ++R G+ ++ GD + R+R+I++ + YV+SPLDI PE + G FG +DD + Y+ LFR L Sbjct: 73 ARAPDVCPICLEGITFGIETNCRHQFCGSCFCAYWQHTSPLAQPNCPVCRGQLRFLVKCFTPEEIQADATQERSDVESQIALFNRRYSGNPVSFLDQLRDLPALMRYGVRALLDGDGISCLLRLRLIVLSLFVFFYVVSPLDIFPESVVGAFGLLDDCLVCVVFFIYMAALFRGRLAA 250
BLAST of E3 ubiquitin-protein ligase RNF170 vs. TrEMBL
Match: A0A2C9K1H4 (RING-type domain-containing protein OS=Biomphalaria glabrata OX=6526 GN=106077814 PE=4 SV=1) HSP 1 Score: 145.591 bits (366), Expect = 6.745e-37 Identity = 75/201 (37.31%), Postives = 113/201 (56.22%), Query Frame = 3 Query: 678 SSYNLHSTYEIQYQEFLNQ---ARNENIHSNAPNRCPVCLEGCKYSIKTSCSHMFCGQCLIGWSNTVNFPGGTTCPVCRTLIKFLLQYFNQDEITSESTEKSDVSNFVKYYNRRYSGMSVSVIDQIRDFPTILRNGIWRIIQ-GDFNFAFRMRIIIVIAGMVLYVLSPLDILPEFLFGIFGFVDDIAAIFLTLSYLNYLFR 1268 S+N +T Q Q Q R N ++ +CP+CL ++I+T+C H+FCG C+I + + G CP CRT + LL F +E ES E+ +V V YNRRYSG + ++ + ++D PT+LR+ G + FR+RI+I++ +Y++SPLDILPE FGI GF+DDI I Y++ L+R Sbjct: 48 DSFNNVATTREQLQTEGGQRGSQRRANHANDGSLQCPICLGSAAFAIETNCGHVFCGHCMITYWEHQTWLGAVRCPSCRTQVSLLLLNFTSEEHAHESDERREVITKVNQYNRRYSGEARTIQEYLQDLPTLLRHTFHEFFSIGGLMWMFRLRIVILVIAAFVYLVSPLDILPEGAFGIIGFLDDIFIILFIAVYISVLYR 248
BLAST of E3 ubiquitin-protein ligase RNF170 vs. TrEMBL
Match: A0A4W3K3X3 (RING-type domain-containing protein OS=Callorhinchus milii OX=7868 GN=rnf170 PE=4 SV=1) HSP 1 Score: 145.976 bits (367), Expect = 7.498e-37 Identity = 73/214 (34.11%), Postives = 118/214 (55.14%), Query Frame = 3 Query: 675 NSSYNLHSTYEIQYQEFLNQARNENI-HSNAPNR----------CPVCLEGCKYSIKTSCSHMFCGQCLIGWSNTVNFPGGTTCPVCRTLIKFLLQYFNQDEITSESTEKSDVSNFVKYYNRRYSGMSVSVIDQIRDFPTILRNGIWRIIQ-GDFNFAFRMRIIIVIAGMVLYVLSPLDILPEFLFGIFGFVDDIAAIFLTLSYLNYLFRRSLT 1280 N N+H + + +E + E + H +AP + CPVCL+ + ++T+C H+FCG C+I + + G CP+CR ++ L F ++ + E + + YNRR+SG S +D+I D PT+LR+ + G + FR+RI++ +AG + Y+ SPLD LPE LFGI GF+DD+ IFL L Y++ ++R +T Sbjct: 47 NEQQNIHPENQERVRELRQHLQAEALNHQDAPAQDRQLFYTDMSCPVCLQQAAFPVETNCGHLFCGSCIIAYWRYGTWLGAVNCPICRQMVTLLFPLFPVND--QQLPESMQIIQEINNYNRRFSGQPRSWMDRIMDLPTLLRHAFTELFTIGGLFWMFRIRILLCLAGALFYLASPLDFLPEALFGILGFLDDLFVIFLLLIYISIMYREVVT 258
BLAST of E3 ubiquitin-protein ligase RNF170 vs. TrEMBL
Match: G3SSU1 (Ring finger protein 170 OS=Loxodonta africana OX=9785 GN=RNF170 PE=4 SV=1) HSP 1 Score: 144.436 bits (363), Expect = 1.991e-36 Identity = 72/211 (34.12%), Postives = 118/211 (55.92%), Query Frame = 3 Query: 675 NSSYNLHSTYEIQYQEFLNQARNENIHSNAPNR-------CPVCLEGCKYSIKTSCSHMFCGQCLIGWSNTVNFPGGTTCPVCRTLIKFLLQYFNQDEITSESTE-KSDVSNFVKYYNRRYSGMSVSVIDQIRDFPTILRNGIWRIIQ-GDFNFAFRMRIIIVIAGMVLYVLSPLDILPEFLFGIFGFVDDIAAIFLTLSYLNYLFRRSLT 1280 N+ N+H + +E Q + E + A + CP+CL + ++T+C H+FCG C+I + + G +CP+CR + LL F D+ T + + D+++ YNRR+SG S++++I D PT+LR+ + G + FR+RII+ + G Y++SPLD +PE LFGI GF+DD IFL L Y++ ++R +T Sbjct: 50 NAHQNIHPENQELVRELREQLQTEQDATAAARQQFYTDMYCPICLHQASFPVETNCGHLFCGTCIIAYWRYGTWLGAISCPICRQTVTLLLTVFGDDDQTQDVVRLRQDIND----YNRRFSGQPRSILERIMDLPTLLRHAFREMFSVGGLFWMFRVRIILCLMGAFFYLISPLDFVPEALFGILGFLDDFFVIFLLLIYISIMYREVIT 256
BLAST of E3 ubiquitin-protein ligase RNF170 vs. Ensembl Cavefish
Match: rnf170 (ring finger protein 170 [Source:NCBI gene;Acc:406612]) HSP 1 Score: 122.865 bits (307), Expect = 5.621e-32 Identity = 61/170 (35.88%), Postives = 97/170 (57.06%), Query Frame = 3 Query: 774 CPVCLEGCKYSIKTSCSHMFCGQCLIGWSNTVNFPGGTTCPVCRTLIKFLLQYFNQDEITSESTEKSDVSNFVKYYNRRYSGMSVSVIDQIRDFPTILRNGIWRIIQ-GDFNFAFRMRIIIVIAGMVLYVLSPLDILPEFLFGIFGFVDDIAAIFLTLSYLNYLFRRSLT 1280 CPVCL+ ++T+C H+FCG C+I + + G +CP+CR + + L DV++ YNRR+SG S++D++RD PT+LR+ + G + FR+RII+ + G + Y+ SPLD +PE LFG+ GF+DD I L Y++ ++R +T Sbjct: 85 CPVCLQQAVLPVETNCGHLFCGSCIIAYWRYGTWLGAISCPICRQMTQRLFW--------------GDVND----YNRRFSGQPRSLLDRLRDVPTLLRHAFREMFSVGGLFWMFRIRIILCLVGALTYLASPLDFIPEALFGLLGFMDDFFVILLLFIYISIMYREVVT 236
BLAST of E3 ubiquitin-protein ligase RNF170 vs. Ensembl Cavefish
Match: si:dkey-183n20.15 (E3 ubiquitin-protein ligase RNF170-like [Source:NCBI gene;Acc:103034427]) HSP 1 Score: 90.8929 bits (224), Expect = 1.291e-20 Identity = 55/188 (29.26%), Postives = 92/188 (48.94%), Query Frame = 3 Query: 696 STYEIQYQEFLNQARNENIHSNAPNR---CPVCLEGCKYSIKTSCSHMFCGQCLIGWSNTVNFPGGTTCPVCRTLIKFLLQYFNQDEITSESTEKSDVSNFVKYYNRRYSGMSVSVIDQIRDFPTILRNGIWRII--QGDFNFAFRMRIIIVIAGMVLYVLSPLDILPEFLFGIFGFVDDIAAIFLTL 1244 S + Q Q N + A NR CPVCL+ + ++T+C H+FC CLI + ++ +CP+CR + + F + + + TE V + ++ YN+RYSG + D + D P L I+R + G + F +R+ + G ++SPL+ + G G +DD+A +FL L Sbjct: 19 SQGQPQGQHVRNGEDSSQSCVTAANRDLHCPVCLQSSIFPVETNCGHLFCAPCLISYWKHGSWLDAISCPLCRQKVSVMSHLFGEGRLDRKQTE---VLDHIRDYNKRYSGAPRRLSDYLCDAPLFLLL-IFRTLGNMGGLVWLFLLRVAVCGFGAAASLVSPLEAVSGPFNGAVGLLDDLAVVFLLL 202
BLAST of E3 ubiquitin-protein ligase RNF170 vs. Ensembl Cavefish
Match: ENSAMXT00000044228.1 (high mobility group protein B2-like [Source:NCBI gene;Acc:103034313]) HSP 1 Score: 76.2554 bits (186), Expect = 1.477e-15 Identity = 38/88 (43.18%), Postives = 57/88 (64.77%), Query Frame = 2 Query: 8 RKIKDPNKPKGAWTAFFFFSDEHRKKIKEENPEYKVGDVAKVLGKMWE--ACKDKSKYEEQAKRDKERYNKELEEYKSGTPVSKKTKG 265 RK KDPN PK +AFF F EHR +K E+P +G++AK LG+ W + KD+S ++++A +E+Y KE+ Y+SG V+K+ G Sbjct: 88 RKKKDPNAPKRPPSAFFIFCSEHRPAVKSEHPNLTIGEIAKKLGEKWSKLSTKDRSPFDQKAVLLREKYEKEVAAYRSGGSVAKRGPG 175 HSP 2 Score: 48.1358 bits (113), Expect = 5.729e-6 Identity = 29/76 (38.16%), Postives = 47/76 (61.84%), Query Frame = 2 Query: 14 IKDPNKPKGAWTAFFFFSDEHRKKIKEENPEYKV--GDVAKVLGKMWEAC--KDKSKYEEQAKRDKERYNKELEEY 229 +KD NKPKG +A+ FF R ++K+++P V G +K + W+A +K K+E+ AK DK RY++E++ Y Sbjct: 2 VKDANKPKGRTSAYAFFVLSSRDELKKKSPGTSVNFGKFSKKCSEDWKALTPSEKKKFEDLAKADKARYDEEMKSY 77
BLAST of E3 ubiquitin-protein ligase RNF170 vs. Ensembl Cavefish
Match: hmgb2a (high mobility group box 2 [Source:NCBI gene;Acc:111195933]) HSP 1 Score: 72.7886 bits (177), Expect = 1.794e-14 Identity = 34/74 (45.95%), Postives = 52/74 (70.27%), Query Frame = 2 Query: 20 DPNKPKGAWTAFFFFSDEHRKKIKEENPEYKVGDVAKVLGKMW--EACKDKSKYEEQAKRDKERYNKELEEYKS 235 DPN PK +AFF F +HR K+K E+P +GD+AK LG+MW ++ KDK+ YE++A + KE+Y K++ Y++ Sbjct: 91 DPNAPKRPPSAFFVFCSDHRPKVKSEHPGISIGDIAKKLGEMWSKQSPKDKAPYEQKAMKLKEKYEKDVAAYRA 164
BLAST of E3 ubiquitin-protein ligase RNF170 vs. Ensembl Cavefish
Match: hmgb1a (high mobility group-T protein-like [Source:NCBI gene;Acc:103039534]) HSP 1 Score: 65.4698 bits (158), Expect = 5.617e-12 Identity = 38/83 (45.78%), Postives = 55/83 (66.27%), Query Frame = 2 Query: 5 KRKIKDPNKPKGAWTAFFFFSDEHRKKIKEENPEYKVGDVAKVLGKMW--EACKDKSKYEEQAKRDKERYNKELEEYKSGTPV 247 K++ KDPN PK +AFF F E+R K+KEE P +GDVAK LG+MW + ++K YE++A + KE+Y K++ Y+ G V Sbjct: 85 KKRFKDPNAPKRPPSAFFIFCAEYRPKVKEETPGLSIGDVAKKLGEMWNKTSAEEKQPYEKKAAKLKEKYEKDIAAYRKGKVV 167
BLAST of E3 ubiquitin-protein ligase RNF170 vs. Ensembl Sea Lamprey
Match: hmgb2b (high mobility group box 2b [Source:ZFIN;Acc:ZDB-GENE-040912-122]) HSP 1 Score: 68.1662 bits (165), Expect = 1.611e-13 Identity = 38/90 (42.22%), Postives = 56/90 (62.22%), Query Frame = 2 Query: 8 RKIKDPNKPKGAWTAFFFFSDEHRKKIKEENPEYKVGDVAKVLGKMW--EACKDKSKYEEQAKRDKERYNKELEEYKSGTPVSKKTKGAG 271 RK KDPN PK +AFF + E+R K++ ENP +G +AK LG+MW +KS YE + + KE+Y+K++ Y+S V + +KGA Sbjct: 88 RKKKDPNAPKRPPSAFFIYCAEYRSKVRAENPGLTIGSIAKKLGEMWNNAPADEKSIYERKTAKLKEKYDKDMASYRSKGKV-ETSKGAS 176
BLAST of E3 ubiquitin-protein ligase RNF170 vs. Ensembl Sea Lamprey
Match: hmgb2a (high mobility group box 2a [Source:ZFIN;Acc:ZDB-GENE-051120-126]) HSP 1 Score: 62.3882 bits (150), Expect = 1.044e-11 Identity = 36/79 (45.57%), Postives = 52/79 (65.82%), Query Frame = 2 Query: 2 NKRKIKDPNKPKGAWTAFFFFSDEHRKKIKEENPEYKVGDVAKVLGKMWEAC--KDKSKYEEQAKRDKERYNKELEEYK 232 KRK KDPN PK +AFF F EHR K+K ++P +G++AK LG+MW + KS YE++A + KE+Y K++ Y+ Sbjct: 83 GKRKTKDPNAPKRPPSAFFVFCSEHRPKVKADHPGLGIGEIAKRLGEMWGLLTPETKSPYEKKAAKLKEKYEKDVAAYR 161
BLAST of E3 ubiquitin-protein ligase RNF170 vs. Ensembl Sea Lamprey
Match: ENSPMAT00000004052.1 (pep scaffold:Pmarinus_7.0:GL476375:218436:246333:-1 gene:ENSPMAG00000003679.1 transcript:ENSPMAT00000004052.1 gene_biotype:protein_coding transcript_biotype:protein_coding) HSP 1 Score: 46.595 bits (109), Expect = 8.242e-6 Identity = 22/74 (29.73%), Postives = 43/74 (58.11%), Query Frame = 2 Query: 20 DPNKPKGAWTAFFFFSDEHRKKIKEENPEYKVGDVAKVLGKMWEACKDKSK--YEEQAKRDKERYNKELEEYKS 235 DPN+P+ +A+ F + + IK +NP G+V+K++ MW+ ++ K Y+ + + K+ Y K+L Y++ Sbjct: 205 DPNEPQKPVSAYALFFRDTQAAIKGQNPSATFGEVSKIVASMWDGLGEEQKQAYKRRTEAAKKEYLKQLAAYRA 278
BLAST of E3 ubiquitin-protein ligase RNF170 vs. Ensembl Yeast
Match: NHP6B (High-mobility group (HMG) protein; binds to and remodels nucleosomes; involved in recruiting FACT and other chromatin remodelling complexes to the chromosomes; functionally redundant with Nhp6Ap; required for transcriptional initiation fidelity of some tRNA genes; homologous to mammalian HMGB1 and HMGB2; NHP6B has a paralog, NHP6A, that arose from the whole genome duplication [Source:SGD;Acc:S000002157]) HSP 1 Score: 67.0106 bits (162), Expect = 2.359e-14 Identity = 32/78 (41.03%), Postives = 51/78 (65.38%), Query Frame = 2 Query: 8 RKIKDPNKPKGAWTAFFFFSDEHRKKIKEENPEYKVGDVAKVLGKMWEA--CKDKSKYEEQAKRDKERYNKELEEYKS 235 R+ KDPN PK +A+ FF++E+R ++ ENP+ G V ++LG+ W+A ++K YE +A+ DK+RY E E Y + Sbjct: 19 RRKKDPNAPKRGLSAYMFFANENRDIVRSENPDVTFGQVGRILGERWKALTAEEKQPYESKAQADKKRYESEKELYNA 96
BLAST of E3 ubiquitin-protein ligase RNF170 vs. Ensembl Yeast
Match: NHP6A (High-mobility group (HMG) protein; binds to and remodels nucleosomes; involved in recruiting FACT and other chromatin remodelling complexes to chromosomes; functionally redundant with Nhp6Bp; required for transcriptional initiation fidelity of some tRNA genes; homologous to mammalian HMGB1 and HMGB2; NHP6A has a paralog, NHP6B, that arose from the whole genome duplication; protein abundance increases in response to DNA replication stress [Source:SGD;Acc:S000006256]) HSP 1 Score: 63.1586 bits (152), Expect = 4.486e-13 Identity = 32/74 (43.24%), Postives = 48/74 (64.86%), Query Frame = 2 Query: 20 DPNKPKGAWTAFFFFSDEHRKKIKEENPEYKVGDVAKVLGKMWEAC--KDKSKYEEQAKRDKERYNKELEEYKS 235 DPN PK A +A+ FF++E+R ++ ENP+ G V K LG+ W+A ++K YE +A+ DK+RY E E Y + Sbjct: 17 DPNAPKRALSAYMFFANENRDIVRSENPDITFGQVGKKLGEKWKALTPEEKQPYEAKAQADKKRYESEKELYNA 90
BLAST of E3 ubiquitin-protein ligase RNF170 vs. Ensembl Nematostella
Match: EDO34494 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7SP78]) HSP 1 Score: 102.064 bits (253), Expect = 1.317e-24 Identity = 66/211 (31.28%), Postives = 104/211 (49.29%), Query Frame = 3 Query: 639 ILHCLISLINRFNSSYNLHSTYEIQYQEF-------------LNQARNENIHSNAPN---------RCPVCLEGCKYSIKTSCSHMFCGQCLIGWSNTVNFPGGTTCPVCRTLIKFLLQYFNQDEITSESTEKSDVSNFVKYYNRRYSGMSVSVIDQIRDFPTILRNGIWRIIQ-GDFNFAFRMRIIIVIAGMVLYVLSPLDILPEFLFGI 1202 IL ++SLI +NS + + + + +Q ++ Q NE AP +CPVC+ ++ T+C H FC C+I + + G CPVCR + L F+ +E +S+ + + + YNRR+SG+ SV++ +RD PT+LR + G + RMRII+ LY +SPLDI+PE +FGI Sbjct: 35 ILIAIVSLI--YNSHFRMLNIHPLQAEQVRLARDWLGIGTGGTEQDNNERDEIQAPEPPRAFSNDRQCPVCITDARFLTMTNCGHEFCAPCIITYWRHGRWLGAVQCPVCRQQVNLLFANFSSEESSSDDSHQW--RGEINEYNRRFSGLPRSVMEHLRDLPTLLRQLFSELFSVGGLVWVLRMRIILCFFAAALYFISPLDIIPESVFGI 241
BLAST of E3 ubiquitin-protein ligase RNF170 vs. Ensembl Nematostella
Match: EDO41032 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7S5L8]) HSP 1 Score: 69.707 bits (169), Expect = 1.990e-13 Identity = 33/74 (44.59%), Postives = 47/74 (63.51%), Query Frame = 2 Query: 17 KDPNKPKGAWTAFFFFSDEHRKKIKEENPEYKVGDVAKVLGKMWEAC--KDKSKYEEQAKRDKERYNKELEEYK 232 KD N PK T + F +EHR+K++ ENP+ +V ++LG MW K + E+A++DKERY KELEEY+ Sbjct: 10 KDVNAPKAPLTGYVRFLNEHREKVRSENPDLPFHEVTRILGNMWSQLPTPQKQLFLEEAEKDKERYMKELEEYQ 83
BLAST of E3 ubiquitin-protein ligase RNF170 vs. Ensembl Nematostella
Match: EDO36028 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7SJW6]) HSP 1 Score: 65.4698 bits (158), Expect = 1.392e-12 Identity = 34/83 (40.96%), Postives = 53/83 (63.86%), Query Frame = 2 Query: 20 DPNKPKGAWTAFFFFSDEHRKKIKEENPEYKVGDVAKVLGKMWEACK--DKSKYEEQAKRDKERYNKELEEYKSGTPVSKKTK 262 DPNKPK +A+F F + R +K++NP G ++KVLG+MW DK++Y++ AK+DK RY E++ +K G +K+ K Sbjct: 89 DPNKPKRCLSAYFHFINLKRDDVKKDNPNASGGALSKVLGEMWSKMTDDDKTQYQDMAKKDKVRYESEMKAFKDGKLPAKQNK 171 HSP 2 Score: 47.7506 bits (112), Expect = 1.666e-6 Identity = 24/70 (34.29%), Postives = 46/70 (65.71%), Query Frame = 2 Query: 26 NKPKGAWTAFFFFSDEHRKKIKEENPEYKVGDVAKVLGKMWEACKDKSK--YEEQAKRDKERYNKELEEY 229 NKPKGA +A+ FF + R+K++ E ++ + D +KV + W+ ++ K + ++A +DKER+ +E++ Y Sbjct: 1 NKPKGAKSAYNFFLQDQREKLQREEGKFSLADFSKVSAEKWKNMSEEEKETFVQKAGKDKERFKEEMQSY 70
BLAST of E3 ubiquitin-protein ligase RNF170 vs. Ensembl Nematostella
Match: EDO47230 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7RMY4]) HSP 1 Score: 64.3142 bits (155), Expect = 1.284e-11 Identity = 31/78 (39.74%), Postives = 47/78 (60.26%), Query Frame = 2 Query: 5 KRKIKDPNKPKGAWTAFFFFSDEHRKKIKEENPEYKVGDVAKVLGKMWEACK--DKSKYEEQAKRDKERYNKELEEYK 232 ++ ++D N PK T + F +E R+K++ E+PE +V K+LG W DK +Y + A+RDKERY ELE Y+ Sbjct: 12 RKTLRDTNAPKAPLTGYVQFLNEQREKVRSEHPELPFPEVTKILGAEWSKMSQDDKQRYLDDAERDKERYIIELENYQ 89
BLAST of E3 ubiquitin-protein ligase RNF170 vs. Ensembl Nematostella
Match: EDO39305 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7SAG5]) HSP 1 Score: 59.3066 bits (142), Expect = 1.439e-11 Identity = 27/66 (40.91%), Postives = 48/66 (72.73%), Query Frame = 2 Query: 32 PKGAWTAFFFFSDEHRKKIKEENPEYKVGDVAKVLGKMWEACKDKSKYEEQAKRDKERYNKELEEY 229 PK A +A+ + ++ R++IK++NP V +V+KV G+MW+ DKSK+EE+A +K++Y + ++EY Sbjct: 1 PKRAMSAYMLWLNDTRQEIKDKNPGISVTEVSKVAGEMWKNLTDKSKWEEKAAIEKQKYVQRMKEY 66
BLAST of E3 ubiquitin-protein ligase RNF170 vs. Ensembl Medaka
Match: rnf170 (E3 ubiquitin-protein ligase RNF170 [Source:NCBI gene;Acc:101162541]) HSP 1 Score: 133.65 bits (335), Expect = 1.002e-35 Identity = 78/249 (31.33%), Postives = 133/249 (53.41%), Query Frame = 3 Query: 576 IEGIENXXXXXXXXXXXCFLYILHCLISLINRFNSSYNLHSTYEIQYQ---EFLNQARNENIHSNAPNR------CPVCLEGCKYSIKTSCSHMFCGQCLIGWSNTVNFPGGTTCPVCRTLIKFLLQYFNQ----DEITSESTEKSDVSNFVKYYNRRYSGMSVSVIDQIRDFPTILRNGIWRIIQ-GDFNFAFRMRIIIVIAGMVLYVLSPLDILPEFLFGIFGFVDDIAAIFLTLSYLNYLFRRSLT 1280 IEG+ N +L V++L L L L++L+ R N+H + + + L ++EN + A + CPVCL+ ++T+C H+FCG C++ + + G CP+CR ++ L F++ + + + + YNRR+SG S++D++RD PT+LR+ + G + FR+RI++ + G + Y+ SPLDILPE LFG+ GF+DD I L Y++ ++R +T Sbjct: 20 IEGVSNQVLFVVVLS----LTFLAGLLTLLCR-QDEQNIHPENQEHVRAVRQQLQTEQDENPQAEARQQFYTDMSCPVCLQQAVLPVETNCGHLFCGSCIMAYWRYGTWLGAIHCPICRQIVTLLFPLFHEHAAPQRVQDGEAQPQLILRDINDYNRRFSGQPRSLMDRLRDVPTLLRHAFREMFSVGGLFWMFRIRILLCLVGALTYLASPLDILPEALFGLLGFMDDFFVILLLFVYISIMYREVVT 263
BLAST of E3 ubiquitin-protein ligase RNF170 vs. Ensembl Medaka
Match: hmgb2a (high mobility group protein B2 [Source:NCBI gene;Acc:101157589]) HSP 1 Score: 75.0998 bits (183), Expect = 3.218e-15 Identity = 35/74 (47.30%), Postives = 52/74 (70.27%), Query Frame = 2 Query: 20 DPNKPKGAWTAFFFFSDEHRKKIKEENPEYKVGDVAKVLGKMW--EACKDKSKYEEQAKRDKERYNKELEEYKS 235 DPN PK +AFF F +HR KIKE+NP +GD+AK LG++W ++ KDK+ YE +A + KE+Y K++ Y++ Sbjct: 91 DPNAPKRPPSAFFVFCSDHRPKIKEDNPGISIGDIAKKLGELWATQSAKDKAPYEAKAAKLKEKYEKDVAAYRA 164
BLAST of E3 ubiquitin-protein ligase RNF170 vs. Ensembl Medaka
Match: si:dkey-183n20.15 (E3 ubiquitin-protein ligase RNF170 [Source:NCBI gene;Acc:101156315]) HSP 1 Score: 66.6254 bits (161), Expect = 3.887e-12 Identity = 39/138 (28.26%), Postives = 68/138 (49.28%), Query Frame = 3 Query: 771 RCPVCLEGCKYSIKTSCSHMFCGQCLIGWSNTVNFPGGTTCPVCRTLIKFLLQYFNQDEITSESTEKSDVSNFVKYYNRRYSGMSVSVIDQIRDFPTILR---NGIWRIIQGDFNFAFRMRIIIVIAGMVLYVLSPLD 1175 +CPVCL+ ++ ++T+CSH+FC CL+ + ++ CP+CR + L F + + + V + YNRRYSG + D + D P +L+ G+ + G F R+ + G V+ + PL+ Sbjct: 53 QCPVCLQTPRFPVQTNCSHLFCAPCLLTYWRHGSWLDAINCPLCRQKVSVLCNLFYE---SQSDQQSQQVLGEITDYNRRYSGAPRKMKDYLCDVPLVLQLLARGLGAM--GGLVGLFLFRVALCCVGTVVSISVPLE 185
BLAST of E3 ubiquitin-protein ligase RNF170 vs. Ensembl Medaka
Match: hmgb1a (high mobility group-T protein [Source:NCBI gene;Acc:101165167]) HSP 1 Score: 63.5438 bits (153), Expect = 2.735e-11 Identity = 36/78 (46.15%), Postives = 52/78 (66.67%), Query Frame = 2 Query: 8 RKIKDPNKPKGAWTAFFFFSDEHRKKIKEENPEYKVGDVAKVLGKMW--EACKDKSKYEEQAKRDKERYNKELEEYKS 235 +K KDPN PK +AFF F E R K+K E+P +GDVAK LG+MW + +DK YE++A + KE+Y K++ Y++ Sbjct: 86 KKFKDPNAPKRPPSAFFIFCSEFRPKVKGESPGLTIGDVAKRLGEMWNSTSAEDKQPYEKKAAKLKEKYGKDIAAYRA 163
BLAST of E3 ubiquitin-protein ligase RNF170 vs. Ensembl Medaka
Match: hmgb1b (high mobility group protein B1 [Source:NCBI gene;Acc:101156596]) HSP 1 Score: 59.6918 bits (143), Expect = 4.672e-10 Identity = 34/79 (43.04%), Postives = 53/79 (67.09%), Query Frame = 2 Query: 5 KRKIKDPNKPKGAWTAFFFFSDEHRKKIKEENPEYKVGDVAKVLGKMW--EACKDKSKYEEQAKRDKERYNKELEEYKS 235 K++ KDPN PK +AFF F + R KIK E+P +GD AK LG+MW + ++K YE++A + KE+Y+K++ Y++ Sbjct: 85 KKRFKDPNAPKRPPSAFFLFCADFRPKIKSESPGLSIGDTAKKLGEMWNSSSAEEKQPYEKKAAKLKEKYDKDIVAYRT 163
BLAST of E3 ubiquitin-protein ligase RNF170 vs. Planmine SMEST
Match: SMESG000068288.1 (SMESG000068288.1) HSP 1 Score: 448.358 bits (1152), Expect = 5.655e-159 Identity = 218/219 (99.54%), Postives = 218/219 (99.54%), Query Frame = 3 Query: 627 CFLYILHCLISLINRFNSSYNLHSTYEIQYQEFLNQARNENIHSNAPNRCPVCLEGCKYSIKTSCSHMFCGQCLIGWSNTVNFPGGTTCPVCRTLIKFLLQYFNQDEITSESTEKSDVSNFVKYYNRRYSGMSVSVIDQIRDFPTILRNGIWRIIQGDFNFAFRMRIIIVIAGMVLYVLSPLDILPEFLFGIFGFVDDIAAIFLTLSYLNYLFRRSLTT 1283 CFLYILHCLISLINRFN SYNLHSTYEIQYQEFLNQARNENIHSNAPNRCPVCLEGCKYSIKTSCSHMFCGQCLIGWSNTVNFPGGTTCPVCRTLIKFLLQYFNQDEITSESTEKSDVSNFVKYYNRRYSGMSVSVIDQIRDFPTILRNGIWRIIQGDFNFAFRMRIIIVIAGMVLYVLSPLDILPEFLFGIFGFVDDIAAIFLTLSYLNYLFRRSLTT Sbjct: 4 CFLYILHCLISLINRFNISYNLHSTYEIQYQEFLNQARNENIHSNAPNRCPVCLEGCKYSIKTSCSHMFCGQCLIGWSNTVNFPGGTTCPVCRTLIKFLLQYFNQDEITSESTEKSDVSNFVKYYNRRYSGMSVSVIDQIRDFPTILRNGIWRIIQGDFNFAFRMRIIIVIAGMVLYVLSPLDILPEFLFGIFGFVDDIAAIFLTLSYLNYLFRRSLTT 222
BLAST of E3 ubiquitin-protein ligase RNF170 vs. Planmine SMEST
Match: SMESG000068286.1 (SMESG000068286.1) HSP 1 Score: 198.364 bits (503), Expect = 2.360e-61 Identity = 97/97 (100.00%), Postives = 97/97 (100.00%), Query Frame = 2 Query: 2 NKRKIKDPNKPKGAWTAFFFFSDEHRKKIKEENPEYKVGDVAKVLGKMWEACKDKSKYEEQAKRDKERYNKELEEYKSGTPVSKKTKGAGDQVNGNH 292 NKRKIKDPNKPKGAWTAFFFFSDEHRKKIKEENPEYKVGDVAKVLGKMWEACKDKSKYEEQAKRDKERYNKELEEYKSGTPVSKKTKGAGDQVNGNH Sbjct: 83 NKRKIKDPNKPKGAWTAFFFFSDEHRKKIKEENPEYKVGDVAKVLGKMWEACKDKSKYEEQAKRDKERYNKELEEYKSGTPVSKKTKGAGDQVNGNH 179
BLAST of E3 ubiquitin-protein ligase RNF170 vs. Planmine SMEST
Match: SMESG000020771.1 (SMESG000020771.1) HSP 1 Score: 123.25 bits (308), Expect = 8.104e-33 Identity = 58/87 (66.67%), Postives = 70/87 (80.46%), Query Frame = 2 Query: 5 KRKIKDPNKPKGAWTAFFFFSDEHRKKIKEENPEYKVGDVAKVLGKMWEACKDKSKYEEQAKRDKERYNKELEEYKSGTPVSKKTKG 265 KR+ KDPNKPK TAFFFFS+EHR+ +KE+NPE+KVGD+AKVLGKMW CKDKSKYEE K KE+YN + EYK+G P +KK+K Sbjct: 89 KREAKDPNKPKAPLTAFFFFSNEHRQTVKEKNPEFKVGDIAKVLGKMWSECKDKSKYEEMNKEAKEKYNLAMLEYKNGAPSAKKSKA 175
BLAST of E3 ubiquitin-protein ligase RNF170 vs. Planmine SMEST
Match: SMESG000015032.1 (SMESG000015032.1) HSP 1 Score: 123.25 bits (308), Expect = 2.760e-32 Identity = 65/198 (32.83%), Postives = 110/198 (55.56%), Query Frame = 3 Query: 687 NLHSTYEIQYQEFLNQARNENIHSNAPNRCPVCLEGCKYSIKTSCSHMFCGQCLIGWSNTVNFPGGTTCPVCRTLIKFLLQYFNQDEITSESTEKSDVSNFVKYYNRRYSGMSVSVIDQIRDFPTILRNGIWRIIQG-DFNFAFRMRIIIVIAGMVLYVLSPLDILPEFLFGIFGFVDDIAAIFLTLSYLNYLFRRSL 1277 ++ I+ Q ++ +RNE + CP+CL+ ++ ++T+C H FCG C + + NF CP+CRT + L++ F+ +E + S K + + + +NR YS + I+QI D P ILR+G ++ G + R+RI ++ ++ Y LSPLDI+PE FG+ G +DDI + L Y+ FRR++ Sbjct: 40 SVEDVSSIRDQISVSHSRNE-VEIYDSEICPICLDNFEFKVETNCGHEFCGSCFTLYWHVGNFVRSVNCPMCRTNVNLLVKSFSPNENLTNSDNKKRIVDEINCFNRLYSDAPRTWIEQIYDIPVILRHGFRHMLDGSSISIIHRLRITVLSIIVIGYCLSPLDIIPESGFGVLGILDDILILITFLMYILVFFRRAV 236
BLAST of E3 ubiquitin-protein ligase RNF170 vs. Planmine SMEST
Match: SMESG000034017.1 (SMESG000034017.1) HSP 1 Score: 97.8265 bits (242), Expect = 3.006e-23 Identity = 40/80 (50.00%), Postives = 64/80 (80.00%), Query Frame = 2 Query: 23 PNKPKGAWTAFFFFSDEHRKKIKEENPEYKVGDVAKVLGKMWEACKDKSKYEEQAKRDKERYNKELEEYKSGTPVSKKTK 262 P +PK AW+AFF+F DE R K+++E+P+++V +VA+ LG++WEAC D+ +YE+ A DKERY KE+E++++G V+ +TK Sbjct: 87 PGQPKRAWSAFFYFCDERRPKVRKEHPDWRVAEVARELGRLWEACSDRDRYEKMATLDKERYEKEMEQFRAGNFVAGETK 166 The following BLAST results are available for this feature:
BLAST of E3 ubiquitin-protein ligase RNF170 vs. Ensembl Human
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Human e!99) Total hits: 5
BLAST of E3 ubiquitin-protein ligase RNF170 vs. Ensembl Celegans
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99) Total hits: 5
BLAST of E3 ubiquitin-protein ligase RNF170 vs. Ensembl Fly
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99) Total hits: 5
BLAST of E3 ubiquitin-protein ligase RNF170 vs. Ensembl Zebrafish
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99) Total hits: 5
BLAST of E3 ubiquitin-protein ligase RNF170 vs. Ensembl Xenopus
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99) Total hits: 5
BLAST of E3 ubiquitin-protein ligase RNF170 vs. Ensembl Mouse
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99) Total hits: 5
BLAST of E3 ubiquitin-protein ligase RNF170 vs. UniProt/SwissProt
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt) Total hits: 5
BLAST of E3 ubiquitin-protein ligase RNF170 vs. TrEMBL
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL) Total hits: 5
BLAST of E3 ubiquitin-protein ligase RNF170 vs. Ensembl Cavefish
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99) Total hits: 5
BLAST of E3 ubiquitin-protein ligase RNF170 vs. Ensembl Sea Lamprey
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99) Total hits: 3
BLAST of E3 ubiquitin-protein ligase RNF170 vs. Ensembl Yeast
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46) Total hits: 2
BLAST of E3 ubiquitin-protein ligase RNF170 vs. Ensembl Nematostella
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46) Total hits: 5
BLAST of E3 ubiquitin-protein ligase RNF170 vs. Ensembl Medaka
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99) Total hits: 5
BLAST of E3 ubiquitin-protein ligase RNF170 vs. Planmine SMEST
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST) Total hits: 5
Analyses
This transcript is derived from or has results from the following analyses Sequences
The following sequences are available for this feature:
transcript sequence >SMED30012240 ID=SMED30012240|Name=E3 ubiquitin-protein ligase RNF170|organism=Schmidtea mediterranea sexual|type=transcript|length=1350bpback to top protein sequence of SMED30012240-orf-1 >SMED30012240-orf-1 ID=SMED30012240-orf-1|Name=SMED30012240-orf-1|organism=Schmidtea mediterranea sexual|type=polypeptide|length=111bp NKRKIKDPNKPKGAWTAFFFFSDEHRKKIKEENPEYKVGDVAKVLGKMWEback to top protein sequence of SMED30012240-orf-2 >SMED30012240-orf-2 ID=SMED30012240-orf-2|Name=SMED30012240-orf-2|organism=Schmidtea mediterranea sexual|type=polypeptide|length=239bp MFIEGIENVILLVIMLMIICFLYILHCLISLINRFNSSYNLHSTYEIQYQback to top Annotated Terms
The following terms have been associated with this transcript:
InterPro
Analysis Name: Schmidtea mediteranean smed_20140614 Interproscan
Date Performed: 2020-05-01
|