E3 ubiquitin-protein ligase RNF170

Overview


Name	E3 ubiquitin-protein ligase RNF170
Smed ID	SMED30012240
Length (bp)	1350

Neoblast Clusters

▻ Sub-lethal Irradiated Surviving X1 and X2 Cell Population

Overview

Single cell RNA-seq of pluripotent neoblasts and its early progenies

We isolated X1 neoblasts cells enriched in high piwi-1 expression (Neoblast Population), and profiled ∼7,614 individual cells via scRNA-seq. Unsupervised analyses uncovered 12 distinct classes from 7,088 high-quality cells. We designated these classes Nb1 to Nb12 and ordered them based on high (Nb1) to low (Nb12) piwi-1 expression levels. We further defined groups of genes that best classified the cells parsed into 12 distinct cell clusters to generate a scaled expression heat map of discriminative gene sets for each cluster. Expression of each cluster’s gene signatures was validated using multiplex fluorescence in situ hybridization (FISH) co-stained with piwi-1 and largely confirmed the cell clusters revealed by scRNA-seq.

We also tested sub-lethal irradiation exposure. To profile rare pluripotent stem cells (PSCs) and avoid interference from immediate progenitor cells, we determined a time point after sub-lethal irradiation (7 DPI) with minimal piwi-1+ cells, followed by isolation and single-cell RNA-seq of 1,200 individual cells derived from X1 (Piwi-1 high) and X2 (Piwi-1 low) cell populations (Sub-lethal Irradiated Surviving X1 and X2 Cell Population)

Explore this single cell expression dataset with our NB Cluster Shiny App

Neoblast Population

t-SNE plot shows two-dimensional representation of global gene expression relationships among all neoblasts (n = 7,088 after filter). Cluster identity was assigned based on the top 10 marker genes of each cluster (Table S2), followed by inspection of RNA in situ hybridization patterns. Neoblast groups, Nb.

Expression of E3 ubiquitin-protein ligase RNF170 (SMED30012240) t-SNE clustered cells

Violin plots show distribution of expression levels for E3 ubiquitin-protein ligase RNF170 (SMED30012240) in cells (dots) of each of the 12 neoblast clusters.

Sub-lethal Irradiated Surviving X1 and X2 Cell Population

t-SNE plot of surviving X1 and X2 cells (n = 1,039 after QC filter) after sub-lethal irradiation. Colors indicate unbiased cell classification via graph-based clustering. SL, sub-lethal irradiated cell groups.

Expression of E3 ubiquitin-protein ligase RNF170 (SMED30012240) in the t-SNE clustered sub-lethally irradiated X1 and X2 cells.

Violin plots show distribution of expression levels for E3 ubiquitin-protein ligase RNF170 (SMED30012240) in cells (dots) of each of the 10 clusters of sub-leathally irradiated X1 and X2 cells.

Embryonic Expression

Davies et. al., 2017

Hover the mouse over a column in the graph to view average RPKM values per sample.
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Embryonic Stages: Y: yolk. S2-S8: Stages 2-8. C4: asexual adult. SX: virgin, sexually mature adult.
For further information about sample preparation and analysis for the single animal RNA-Seq experiment, please refer to the Materials and Methods

Anatomical Expression

PAGE et. al., 2020

SMED30012240

has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGE

PAGE Curations: 26

Expressed In	Reference Transcript	Gene Models	Published Transcript	Transcriptome	Publication
X1 cell	SMED30012240	h1SMcG0011094	SmedASXL_004345	SmedAsxl_ww_GCZZ01	PMID:26114597 Zhu et al., 2015
X2 cell	SMED30012240	h1SMcG0011094	SmedASXL_004345	SmedAsxl_ww_GCZZ01	PMID:26114597 Zhu et al., 2015
X1 cell	SMED30012240	h1SMcG0011093	SmedASXL_004345	SmedAsxl_ww_GCZZ01	PMID:26114597 Zhu et al., 2015
X2 cell	SMED30012240	h1SMcG0011093	SmedASXL_004345	SmedAsxl_ww_GCZZ01	PMID:26114597 Zhu et al., 2015
pharynx	SMED30012240	h1SMcG0011094	dd_Smed_v4_802_0_1	dd_Smed_v4	PMID:29674431 Fincher et al., 2018
nervous system	SMED30012240	h1SMcG0011094	dd_Smed_v4_802_0_1	dd_Smed_v4	PMID:29674431 Fincher et al., 2018
gut	SMED30012240	h1SMcG0011094	dd_Smed_v4_802_0_1	dd_Smed_v4	PMID:29674431 Fincher et al., 2018
epidermis	SMED30012240	h1SMcG0011094	dd_Smed_v4_802_0_1	dd_Smed_v4	PMID:29674431 Fincher et al., 2018
cephalic ganglia	SMED30012240	h1SMcG0011094	dd_Smed_v4_802_0_1	dd_Smed_v4	PMID:29674431 Fincher et al., 2018
muscle cell	SMED30012240	h1SMcG0011094	dd_Smed_v4_802_0_1	dd_Smed_v4	PMID:29674431 Fincher et al., 2018
neoblast	SMED30012240	h1SMcG0011094	dd_Smed_v4_802_0_1	dd_Smed_v4	PMID:29674431 Fincher et al., 2018
parenchymal cell	SMED30012240	h1SMcG0011094	dd_Smed_v4_802_0_1	dd_Smed_v4	PMID:29674431 Fincher et al., 2018
Smed sexual biotype	SMED30012240	h1SMcG0011094	Contig37230	uc_Smed_v2	PMID:29674431 Fincher et al., 2018
Smed sexual biotype	SMED30012240	h1SMcG0011094	Contig37230	newmark_ests	PMID:29674431 Fincher et al., 2018
Smed sexual biotype	SMED30012240	h1SMcG0011093	Contig37230	uc_Smed_v2	PMID:29674431 Fincher et al., 2018
Smed sexual biotype	SMED30012240	h1SMcG0011093	Contig37230	newmark_ests	PMID:29674431 Fincher et al., 2018
pharynx	SMED30012240	h1SMcG0011093	dd_Smed_v4_802_0_1	dd_Smed_v4	PMID:29674431 Fincher et al., 2018
nervous system	SMED30012240	h1SMcG0011093	dd_Smed_v4_802_0_1	dd_Smed_v4	PMID:29674431 Fincher et al., 2018
gut	SMED30012240	h1SMcG0011093	dd_Smed_v4_802_0_1	dd_Smed_v4	PMID:29674431 Fincher et al., 2018
epidermis	SMED30012240	h1SMcG0011093	dd_Smed_v4_802_0_1	dd_Smed_v4	PMID:29674431 Fincher et al., 2018
cephalic ganglia	SMED30012240	h1SMcG0011093	dd_Smed_v4_802_0_1	dd_Smed_v4	PMID:29674431 Fincher et al., 2018
muscle cell	SMED30012240	h1SMcG0011093	dd_Smed_v4_802_0_1	dd_Smed_v4	PMID:29674431 Fincher et al., 2018
neoblast	SMED30012240	h1SMcG0011093	dd_Smed_v4_802_0_1	dd_Smed_v4	PMID:29674431 Fincher et al., 2018
parenchymal cell	SMED30012240	h1SMcG0011093	dd_Smed_v4_802_0_1	dd_Smed_v4	PMID:29674431 Fincher et al., 2018
neoblast	SMED30012240	h1SMcG0011094	dd_Smed_v6_802_0	dd_Smed_v6	PMID:29674432 Plass et al., 2018
neoblast	SMED30012240	h1SMcG0011093	dd_Smed_v6_802_0	dd_Smed_v6	PMID:29674432 Plass et al., 2018

Note: Hover over icons to view figure legend

Homology

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BLAST of E3 ubiquitin-protein ligase RNF170 vs. Ensembl Human
Match: RNF170 (ring finger protein 170 [Source:HGNC Symbol;Acc:HGNC:25358])

HSP 1 Score: 141.739 bits (356), Expect = 1.529e-38
Identity = 71/210 (33.81%), Postives = 116/210 (55.24%), Query Frame = 3

Query:  687 NLHSTYEIQYQEFLNQARNE-NIHSNAPNR----------CPVCLEGCKYSIKTSCSHMFCGQCLIGWSNTVNFPGGTTCPVCRTLIKFLLQYFNQDEITSESTEKSDVSNFVKYYNRRYSGMSVSVIDQIRDFPTILRNGIWRIIQ-GDFNFAFRMRIIIVIAGMVLYVLSPLDILPEFLFGIFGFVDDIAAIFLTLSYLNYLFRRSLT 1280
            N+H     + QE +   R +     +AP            CP+CL    + ++T+C H+FCG C+I +    ++ G  +CP+CR  +  LL  F +D+   +S +   +   +  YNRR+SG   S++++I D PT+LR+    +   G   + FR+RII+ + G   Y++SPLD +PE LFGI GF+DD   IFL L Y++ ++R  +T
Sbjct:   47 NVHQNIHPENQELVRVLREQLQTEQDAPAATRQQFYTDMYCPICLHQASFPVETNCGHLFCGACIIAYWRYGSWLGAISCPICRQTVTLLLTVFGEDD---QSQDVLRLHQDINDYNRRFSGQPRSIMERIMDLPTLLRHAFREMFSVGGLFWMFRIRIILCLMGAFFYLISPLDFVPEALFGILGFLDDFFVIFLLLIYISIMYREVIT 253

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Query:  687 NLHSTYEIQYQEFLNQARNE-NIHSNAPNR----------CPVCLEGCKYSIKTSCSHMFCGQCLIGWSNTVNFPGGTTCPVCRTLIKFLLQYFNQDEITSESTEKSDVSNFVKYYNRRYSGMSVSVIDQIRDFPTILRNGIWRIIQ-GDFNFAFRMRIIIVIAGMVLYVLSPLDILPEFLFGIFGFVDDIAAIFLTLSYLNYLFRRSLT 1280
            N+H     + QE +   R +     +AP            CP+CL    + ++T+C H+FCG C+I +    ++ G  +CP+CR  +  LL  F +D+   +S +   +   +  YNRR+SG   S++++I D PT+LR+    +   G   + FR+RII+ + G   Y++SPLD +PE LFGI GF+DD   IFL L Y++ ++R  +T
Sbjct:   47 NVHQNIHPENQELVRVLREQLQTEQDAPAATRQQFYTDMYCPICLHQASFPVETNCGHLFCGACIIAYWRYGSWLGAISCPICRQTVTLLLTVFGEDD---QSQDVLRLHQDINDYNRRFSGQPRSIMERIMDLPTLLRHAFREMFSVGGLFWMFRIRIILCLMGAFFYLISPLDFVPEALFGILGFLDDFFVIFLLLIYISIMYREVIT 253

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BLAST of E3 ubiquitin-protein ligase RNF170 vs. Ensembl Human
Match: RNF170 (ring finger protein 170 [Source:HGNC Symbol;Acc:HGNC:25358])

HSP 1 Score: 137.887 bits (346), Expect = 4.046e-38
Identity = 64/170 (37.65%), Postives = 104/170 (61.18%), Query Frame = 3

Query:  774 CPVCLEGCKYSIKTSCSHMFCGQCLIGWSNTVNFPGGTTCPVCRTLIKFLLQYFNQDEITSESTEKSDVSNFVKYYNRRYSGMSVSVIDQIRDFPTILRNGIWRIIQ-GDFNFAFRMRIIIVIAGMVLYVLSPLDILPEFLFGIFGFVDDIAAIFLTLSYLNYLFRRSLT 1280
            CP+CL    + ++T+C H+FCG C+I +    ++ G  +CP+CR  +  LL  F +D+   +S +   +   +  YNRR+SG   S++++I D PT+LR+    +   G   + FR+RII+ + G   Y++SPLD +PE LFGI GF+DD   IFL L Y++ ++R  +T
Sbjct:    3 CPICLHQASFPVETNCGHLFCGACIIAYWRYGSWLGAISCPICRQTVTLLLTVFGEDD---QSQDVLRLHQDINDYNRRFSGQPRSIMERIMDLPTLLRHAFREMFSVGGLFWMFRIRIILCLMGAFFYLISPLDFVPEALFGILGFLDDFFVIFLLLIYISIMYREVIT 169

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BLAST of E3 ubiquitin-protein ligase RNF170 vs. Ensembl Human
Match: HMGB2 (high mobility group box 2 [Source:HGNC Symbol;Acc:HGNC:5000])

HSP 1 Score: 69.3218 bits (168), Expect = 4.830e-13
Identity = 37/84 (44.05%), Postives = 51/84 (60.71%), Query Frame = 2

Query:   26 NKPKGAWTAFFFFSDEHRKKIKEENPEYKVGDVAKVLGKMW--EACKDKSKYEEQAKRDKERYNKELEEYKSGTPVSKKTKGAG 271
            N PK   +AFF F  EHR KIK E+P   +GD AK LG+MW  ++ KDK  YE++A + KE+Y K++  Y++        KG G
Sbjct:   93 NAPKRPPSAFFLFCSEHRPKIKSEHPGLSIGDTAKKLGEMWSEQSAKDKQPYEQKAAKLKEKYEKDIAAYRAKGKSEAGKKGPG 176

HSP 2 Score: 49.6766 bits (117), Expect = 2.768e-6
Identity = 27/74 (36.49%), Postives = 49/74 (66.22%), Query Frame = 2

Query:   20 DPNKPKGAWTAFFFFSDEHRKKIKEENPEYKV--GDVAKVLGKMWE--ACKDKSKYEEQAKRDKERYNKELEEY 229
            DPNKP+G  +++ FF    R++ K+++P+  V   + +K   + W+  + K+KSK+E+ AK DK RY++E++ Y
Sbjct:    5 DPNKPRGKMSSYAFFVQTCREEHKKKHPDSSVNFAEFSKKCSERWKTMSAKEKSKFEDMAKSDKARYDREMKNY 78

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Query:   26 NKPKGAWTAFFFFSDEHRKKIKEENPEYKVGDVAKVLGKMW--EACKDKSKYEEQAKRDKERYNKELEEYKSGTPVSKKTKGAG 271
            N PK   +AFF F  EHR KIK E+P   +GD AK LG+MW  ++ KDK  YE++A + KE+Y K++  Y++        KG G
Sbjct:   93 NAPKRPPSAFFLFCSEHRPKIKSEHPGLSIGDTAKKLGEMWSEQSAKDKQPYEQKAAKLKEKYEKDIAAYRAKGKSEAGKKGPG 176

HSP 2 Score: 49.6766 bits (117), Expect = 2.768e-6
Identity = 27/74 (36.49%), Postives = 49/74 (66.22%), Query Frame = 2

Query:   20 DPNKPKGAWTAFFFFSDEHRKKIKEENPEYKV--GDVAKVLGKMWE--ACKDKSKYEEQAKRDKERYNKELEEY 229
            DPNKP+G  +++ FF    R++ K+++P+  V   + +K   + W+  + K+KSK+E+ AK DK RY++E++ Y
Sbjct:    5 DPNKPRGKMSSYAFFVQTCREEHKKKHPDSSVNFAEFSKKCSERWKTMSAKEKSKFEDMAKSDKARYDREMKNY 78

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BLAST of E3 ubiquitin-protein ligase RNF170 vs. Ensembl Celegans
Match: Y38F1A.2 (pep chromosome:WBcel235:II:12954962:12958018:1 gene:WBGene00012606.1 transcript:Y38F1A.2.1 gene_biotype:protein_coding transcript_biotype:protein_coding gene_symbol:Y38F1A.2)

HSP 1 Score: 88.1965 bits (217), Expect = 1.981e-19
Identity = 55/175 (31.43%), Postives = 91/175 (52.00%), Query Frame = 3

Query:  711 QYQEFLNQAR-NENIHSNAPNRCPVCLEGCKYSIKTSCSHMFCGQCLIG-WSNTVNFPGGTTCPVCRTLIKFLLQYFNQDEITSESTEKSDVSNFVKY--YNRRYSGMSVSVIDQIRDFPTILRNGIWRIIQGD-FNFAFRMRIIIVIAGMVLYVLSPLDILPEFLFGIFGFVDD 1220
            +  + + Q R +E +H ++ + CP+CL    + + T C H+FC +C+I  W  +        C +CR+    LL        TSE T+     N ++   YNRR+S ++  V+D IRD P ++   I      D F   +++RI  V   ++ Y L P D++PE ++GI GF+DD
Sbjct:   84 ERNQIITQRRISEALHQSS-HECPICLANASFPVLTDCGHIFCCECIIQYWQQSKAIVTPCDCAMCRSTFYMLLPVHWPTMGTSEETDDHIQENNIRIDDYNRRFS-INRPVLDYIRDIPILIPYLIRNFFNNDIFTLVYQVRIGFVFICVITYFLLPSDMVPESIYGIIGFLDD 256

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BLAST of E3 ubiquitin-protein ligase RNF170 vs. Ensembl Celegans
Match: hmg-1.2 (High mobility group protein 1.2 [Source:UniProtKB/Swiss-Prot;Acc:Q09390])

HSP 1 Score: 73.9442 bits (180), Expect = 9.581e-15
Identity = 37/79 (46.84%), Postives = 56/79 (70.89%), Query Frame = 2

Query:    5 KRKIKDPNKPKGAWTAFFFFSDEHRKKIKEENPEYKVGDVAKVLGKMWEACKDKSK--YEEQAKRDKERYNKELEEYKS 235
            KR  KDP+ PK A +AFFF+S + R +I+  +P++KVG VA+ LGKMW+    ++K  YE++A+ DK+RY  E+  YK+
Sbjct:  126 KRAKKDPHAPKRALSAFFFYSQDKRPEIQAGHPDWKVGQVAQELGKMWKLVPQETKDMYEQKAQADKDRYADEMRNYKA 204

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Query:    5 KRKIKDPNKPKGAWTAFFFFSDEHRKKIKEENPEYKVGDVAKVLGKMWEACKDKSK--YEEQAKRDKERYNKELEEYKS 235
            KR  KDP+ PK A +AFFF+S + R +I+  +P++KVG VA+ LGKMW+    ++K  YE++A+ DK+RY  E+  YK+
Sbjct:  126 KRAKKDPHAPKRALSAFFFYSQDKRPEIQAGHPDWKVGQVAQELGKMWKLVPQETKDMYEQKAQADKDRYADEMRNYKA 204

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BLAST of E3 ubiquitin-protein ligase RNF170 vs. Ensembl Celegans
Match: hmg-1.2 (High mobility group protein 1.2 [Source:UniProtKB/Swiss-Prot;Acc:Q09390])

HSP 1 Score: 73.9442 bits (180), Expect = 9.699e-15
Identity = 37/79 (46.84%), Postives = 56/79 (70.89%), Query Frame = 2

Query:    5 KRKIKDPNKPKGAWTAFFFFSDEHRKKIKEENPEYKVGDVAKVLGKMWEACKDKSK--YEEQAKRDKERYNKELEEYKS 235
            KR  KDP+ PK A +AFFF+S + R +I+  +P++KVG VA+ LGKMW+    ++K  YE++A+ DK+RY  E+  YK+
Sbjct:  125 KRAKKDPHAPKRALSAFFFYSQDKRPEIQAGHPDWKVGQVAQELGKMWKLVPQETKDMYEQKAQADKDRYADEMRNYKA 203

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BLAST of E3 ubiquitin-protein ligase RNF170 vs. Ensembl Celegans
Match: hmg-1.2 (High mobility group protein 1.2 [Source:UniProtKB/Swiss-Prot;Acc:Q09390])

HSP 1 Score: 73.559 bits (179), Expect = 1.020e-14
Identity = 37/79 (46.84%), Postives = 56/79 (70.89%), Query Frame = 2

Query:    5 KRKIKDPNKPKGAWTAFFFFSDEHRKKIKEENPEYKVGDVAKVLGKMWEACKDKSK--YEEQAKRDKERYNKELEEYKS 235
            KR  KDP+ PK A +AFFF+S + R +I+  +P++KVG VA+ LGKMW+    ++K  YE++A+ DK+RY  E+  YK+
Sbjct:  124 KRAKKDPHAPKRALSAFFFYSQDKRPEIQAGHPDWKVGQVAQELGKMWKLVPQETKDMYEQKAQADKDRYADEMRNYKA 202

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BLAST of E3 ubiquitin-protein ligase RNF170 vs. Ensembl Fly
Match: Dsp1 (gene:FBgn0278608 transcript:FBtr0089259)

HSP 1 Score: 81.6481 bits (200), Expect = 1.477e-16
Identity = 39/84 (46.43%), Postives = 58/84 (69.05%), Query Frame = 2

Query:    5 KRKIKDPNKPKGAWTAFFFFSDEHRKKIKEENPEYKVGDVAKVLGKMWEAC--KDKSKYEEQAKRDKERYNKELEEYKSGTPVS 250
            +++IKDPN PK + +AFF+F ++ R K+K  NPE+ VGD+AK LG+ W     + K KYE  A+RDK RY +E+ EYK+   ++
Sbjct:  254 RKQIKDPNAPKRSLSAFFWFCNDERNKVKALNPEFGVGDIAKELGRKWSDVDPEVKQKYESMAERDKARYEREMTEYKTSGKIA 337

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BLAST of E3 ubiquitin-protein ligase RNF170 vs. Ensembl Fly
Match: Dsp1 (gene:FBgn0278608 transcript:FBtr0089260)

HSP 1 Score: 81.6481 bits (200), Expect = 1.477e-16
Identity = 39/84 (46.43%), Postives = 58/84 (69.05%), Query Frame = 2

Query:    5 KRKIKDPNKPKGAWTAFFFFSDEHRKKIKEENPEYKVGDVAKVLGKMWEAC--KDKSKYEEQAKRDKERYNKELEEYKSGTPVS 250
            +++IKDPN PK + +AFF+F ++ R K+K  NPE+ VGD+AK LG+ W     + K KYE  A+RDK RY +E+ EYK+   ++
Sbjct:  254 RKQIKDPNAPKRSLSAFFWFCNDERNKVKALNPEFGVGDIAKELGRKWSDVDPEVKQKYESMAERDKARYEREMTEYKTSGKIA 337

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BLAST of E3 ubiquitin-protein ligase RNF170 vs. Ensembl Fly
Match: Dsp1 (gene:FBgn0278608 transcript:FBtr0089261)

HSP 1 Score: 81.6481 bits (200), Expect = 1.477e-16
Identity = 39/84 (46.43%), Postives = 58/84 (69.05%), Query Frame = 2

Query:    5 KRKIKDPNKPKGAWTAFFFFSDEHRKKIKEENPEYKVGDVAKVLGKMWEAC--KDKSKYEEQAKRDKERYNKELEEYKSGTPVS 250
            +++IKDPN PK + +AFF+F ++ R K+K  NPE+ VGD+AK LG+ W     + K KYE  A+RDK RY +E+ EYK+   ++
Sbjct:  254 RKQIKDPNAPKRSLSAFFWFCNDERNKVKALNPEFGVGDIAKELGRKWSDVDPEVKQKYESMAERDKARYEREMTEYKTSGKIA 337

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BLAST of E3 ubiquitin-protein ligase RNF170 vs. Ensembl Fly
Match: Dsp1 (gene:FBgn0278608 transcript:FBtr0089262)

HSP 1 Score: 81.6481 bits (200), Expect = 1.487e-16
Identity = 39/84 (46.43%), Postives = 58/84 (69.05%), Query Frame = 2

Query:    5 KRKIKDPNKPKGAWTAFFFFSDEHRKKIKEENPEYKVGDVAKVLGKMWEAC--KDKSKYEEQAKRDKERYNKELEEYKSGTPVS 250
            +++IKDPN PK + +AFF+F ++ R K+K  NPE+ VGD+AK LG+ W     + K KYE  A+RDK RY +E+ EYK+   ++
Sbjct:  255 RKQIKDPNAPKRSLSAFFWFCNDERNKVKALNPEFGVGDIAKELGRKWSDVDPEVKQKYESMAERDKARYEREMTEYKTSGKIA 338

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BLAST of E3 ubiquitin-protein ligase RNF170 vs. Ensembl Fly
Match: Dsp1 (gene:FBgn0278608 transcript:FBtr0339766)

HSP 1 Score: 81.6481 bits (200), Expect = 1.487e-16
Identity = 39/84 (46.43%), Postives = 58/84 (69.05%), Query Frame = 2

Query:    5 KRKIKDPNKPKGAWTAFFFFSDEHRKKIKEENPEYKVGDVAKVLGKMWEAC--KDKSKYEEQAKRDKERYNKELEEYKSGTPVS 250
            +++IKDPN PK + +AFF+F ++ R K+K  NPE+ VGD+AK LG+ W     + K KYE  A+RDK RY +E+ EYK+   ++
Sbjct:  255 RKQIKDPNAPKRSLSAFFWFCNDERNKVKALNPEFGVGDIAKELGRKWSDVDPEVKQKYESMAERDKARYEREMTEYKTSGKIA 338

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BLAST of E3 ubiquitin-protein ligase RNF170 vs. Ensembl Zebrafish
Match: rnf170 (ring finger protein 170 [Source:NCBI gene;Acc:406612])

HSP 1 Score: 132.494 bits (332), Expect = 3.402e-35
Identity = 64/213 (30.05%), Postives = 116/213 (54.46%), Query Frame = 3

Query:  675 NSSYNLHSTYEIQYQEFLNQARNENIHSNAPNR------CPVCLEGCKYSIKTSCSHMFCGQCLIGWSNTVNFPGGTTCPVCRTLIKFLLQYFNQDEITSEST----EKSDVSNFVKYYNRRYSGMSVSVIDQIRDFPTILRNGIWRIIQ-GDFNFAFRMRIIIVIAGMVLYVLSPLDILPEFLFGIFGFVDDIAAIFLTLSYLNYLFRRSLT 1280
            +    +H   + + +    Q + E + S + ++      CPVCL+     ++T+C H+FCG C+I +     + G  +CP+CR ++  L   F   E ++ +     E + +   +  YNRR+SG   S++D++RD PT+LR+    +   G   + FR+RI++ + G + Y++SPLD LPE + G+ GF+DD   I L   Y++ ++R  +T
Sbjct:   49 SEQQRIHPESQERVRVVREQLQAEQVSSESRHQFYSDMSCPVCLQQAVLPVETNCGHLFCGSCIIAYWRYGTWLGAISCPICRQMVTLLFPLFQDSEQSAVAADSLVEPTLILTDISDYNRRFSGQPRSLLDRLRDVPTLLRHAFREMFSVGGLFWMFRVRILLCVCGALAYLVSPLDFLPEGVLGLLGFLDDFFVILLLFIYISIMYREVVT 261

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Query:  675 NSSYNLHSTYEIQYQEFLNQARNENIHSNAPNR------CPVCLEGCKYSIKTSCSHMFCGQCLIGWSNTVNFPGGTTCPVCRTLIKFLLQYFNQDEITSEST----EKSDVSNFVKYYNRRYSGMSVSVIDQIRDFPTILRNGIWRIIQ-GDFNFAFRMRIIIVIAGMVLYVLSPLDILPEFLFGIFGFVDDIAAIFLTLSYLNYLFRRSLT 1280
            +    +H   + + +    Q + E + S + ++      CPVCL+     ++T+C H+FCG C+I +     + G  +CP+CR ++  L   F   E ++ +     E + +   +  YNRR+SG   S++D++RD PT+LR+    +   G   + FR+RI++ + G + Y++SPLD LPE + G+ GF+DD   I L   Y++ ++R  +T
Sbjct:   49 SEQQRIHPESQERVRVVREQLQAEQVSSESRHQFYSDMSCPVCLQQAVLPVETNCGHLFCGSCIIAYWRYGTWLGAISCPICRQMVTLLFPLFQDSEQSAVAADSLVEPTLILTDISDYNRRFSGQPRSLLDRLRDVPTLLRHAFREMFSVGGLFWMFRVRILLCVCGALAYLVSPLDFLPEGVLGLLGFLDDFFVILLLFIYISIMYREVVT 261

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BLAST of E3 ubiquitin-protein ligase RNF170 vs. Ensembl Zebrafish
Match: si:dkey-183n20.15 (si:dkey-183n20.15 [Source:ZFIN;Acc:ZDB-GENE-041001-160])

HSP 1 Score: 85.8853 bits (211), Expect = 8.773e-19
Identity = 55/201 (27.36%), Postives = 91/201 (45.27%), Query Frame = 3

Query:  651 LISLINRFNSSYNLHSTYEIQYQEFLNQARNENIHSNAPNRCPVCLEGCKYSIKTSCSHMFCGQCLIGWSNTVNFPGGTTCPVCRTLIKFLLQYFNQDEITSESTEKSDVSNFVKYYNRRYSGMSVSVIDQIRDFP---TILRNGIWRIIQGDFNFAFRMRIIIVIAGMVLYVLSPLDILPEFLFGIFGFVDDIAAIFLTL 1244
            L+  I      +N H        +    A + ++H      CPVCL+   Y ++T+C H+FC  CLI +    ++    +CP+CR  +K +   F++++   +  E   V   V+ YN+RYSG    V D + D P    +L  G+  +  G   + F +R+ +   G  +     L  LP  L    G +DD   +FL L
Sbjct:   13 LLPKIRSQGCPHNAHVNNREDLPKMWLPAGSRDVH------CPVCLQMATYPVETNCGHLFCAPCLISYWKHCSWLDAISCPLCRQTVKKMCHLFSENKTDCKERE---VLRHVRDYNKRYSGAPRQVKDYLCDAPLFLLVLVRGLGNM--GGLVWLFLLRVAVCGFGAAMS----LAALPGPLSSALGILDDFVVVFLLL 198

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Query:  651 LISLINRFNSSYNLHSTYEIQYQEFLNQARNENIHSNAPNRCPVCLEGCKYSIKTSCSHMFCGQCLIGWSNTVNFPGGTTCPVCRTLIKFLLQYFNQDEITSESTEKSDVSNFVKYYNRRYSGMSVSVIDQIRDFP---TILRNGIWRIIQGDFNFAFRMRIIIVIAGMVLYVLSPLDILPEFLFGIFGFVDDIAAIFLTL 1244
            L+  I      +N H        +    A + ++H      CPVCL+   Y ++T+C H+FC  CLI +    ++    +CP+CR  +K +   F++++   +  E   V   V+ YN+RYSG    V D + D P    +L  G+  +  G   + F +R+ +   G  +     L  LP  L    G +DD   +FL L
Sbjct:   13 LLPKIRSQGCPHNAHVNNREDLPKMWLPAGSRDVH------CPVCLQMATYPVETNCGHLFCAPCLISYWKHCSWLDAISCPLCRQTVKKMCHLFSENKTDCKERE---VLRHVRDYNKRYSGAPRQVKDYLCDAPLFLLVLVRGLGNM--GGLVWLFLLRVAVCGFGAAMS----LAALPGPLSSALGILDDFVVVFLLL 198

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BLAST of E3 ubiquitin-protein ligase RNF170 vs. Ensembl Zebrafish
Match: hmgb2b (high mobility group box 2b [Source:ZFIN;Acc:ZDB-GENE-040912-122])

HSP 1 Score: 74.7146 bits (182), Expect = 5.497e-15
Identity = 36/88 (40.91%), Postives = 59/88 (67.05%), Query Frame = 2

Query:    8 RKIKDPNKPKGAWTAFFFFSDEHRKKIKEENPEYKVGDVAKVLGKMW--EACKDKSKYEEQAKRDKERYNKELEEYKSGTPVSKKTKG 265
            RK KDPN PK   +AFF F  E+R  +K E+P   +G++AK LG++W  ++ KD++ +E++A + +E+Y KE+  Y++G   SK+  G
Sbjct:   89 RKKKDPNAPKRPPSAFFVFCSEYRPTVKSEHPNLTIGEIAKKLGELWSKQSSKDRAPFEQKAGKLREKYEKEVAAYRAGGGASKRGPG 176

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BLAST of E3 ubiquitin-protein ligase RNF170 vs. Ensembl Xenopus
Match: pcmtd2 (protein-L-isoaspartate (D-aspartate) O-methyltransferase domain containing 2 [Source:Xenbase;Acc:XB-GENE-947888])

HSP 1 Score: 142.124 bits (357), Expect = 1.109e-38
Identity = 70/213 (32.86%), Postives = 118/213 (55.40%), Query Frame = 3

Query:  675 NSSYNLHSTYEIQYQEFLNQARNENIHSNAPN-------RCPVCLEGCKYSIKTSCSHMFCGQCLIGWSNTVNFPGGTTCPVCRTLIKFLLQYFNQDEITSESTEKSDVSNFVKY---YNRRYSGMSVSVIDQIRDFPTILRNGIWRIIQ-GDFNFAFRMRIIIVIAGMVLYVLSPLDILPEFLFGIFGFVDDIAAIFLTLSYLNYLFRRSLT 1280
            N   N+H   + + +    Q +NE      P         CPVCL+   + ++T+C H+FCG C+I +    ++ G   CP+CR  +  +   F       ++TE+ D  N ++    YNRR+SG   S++D+I D PT+LR+    +   G   + FR+RI++ + G + Y++SPLDI+PE +FG+ GF+DD   +FL L Y++ ++R  +T
Sbjct:   47 NDEQNIHPENQDRVRAVREQLQNEQETPPPPRPQFYSDMTCPVCLQQATFPVETNCGHLFCGSCIIAYWRYGSWLGAINCPICRQTVTLIFPLF-------QATEQEDSQNILREAIGYNRRFSGQPRSLMDRIMDLPTLLRHAFREMFSVGGLFWMFRIRIVLCLLGALFYLVSPLDIIPEAVFGLLGFLDDFFVLFLLLIYISIMYREVVT 252

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BLAST of E3 ubiquitin-protein ligase RNF170 vs. Ensembl Xenopus
Match: ENSXETT00000034170.1 (uncharacterized loc100145035 [Source:NCBI gene;Acc:100145035])

HSP 1 Score: 113.62 bits (283), Expect = 2.173e-28
Identity = 62/208 (29.81%), Postives = 110/208 (52.88%), Query Frame = 3

Query:  669 RFNSSYNLHSTYEIQYQEFLNQARNENI------HSNAPNRCPVCLEGCKYSIKTSCSHMFCGQCLIGWSNTVNFPGGTTCPVCRTLIKFLLQYFNQDEITSESTEKSDVSNFVKYYNRRYSGMSVSVIDQIRDFPTILRNGIWRI-IQGDFNFAFRMRIIIVIAGMVLYVLSPLDILPEFLFGIFGFVDDIAAIFLTLSYLNYLFRR 1271
            RF+  Y L        QE L+   N++       H +    CPVCL+     ++T+C H+FCG CL+ +     + G  +CP+CR  +  L   F +++    S    D+ + +++YN R+SG    V D + D P++L  G+ RI   G   + F +RI++ + G+V+   +P D++P+ + GI   +DD+  +FL LS +  +F++
Sbjct:   13 RFSCGYKLDMNSPKPEQEKLSLTNNKDSYKCRQSHFDNDLNCPVCLQTATMPVETNCGHLFCGSCLMTYWKHDPWLGAMSCPLCRQKVVLLYNDFWENQADKLS---RDIVHDIRHYNNRFSGKPRPVTDYLYDMPSLLHLGLRRIFTMGGLVWVFCLRILVCLFGVVVCFSTPFDVIPDPMCGILSIIDDLVVVFLLLSCIINIFQQ 217

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BLAST of E3 ubiquitin-protein ligase RNF170 vs. Ensembl Xenopus
Match: ENSXETT00000034163.1 (uncharacterized loc100145035 [Source:NCBI gene;Acc:100145035])

HSP 1 Score: 111.309 bits (277), Expect = 1.183e-27
Identity = 61/207 (29.47%), Postives = 109/207 (52.66%), Query Frame = 3

Query:  672 FNSSYNLHSTYEIQYQEFLNQARNENI------HSNAPNRCPVCLEGCKYSIKTSCSHMFCGQCLIGWSNTVNFPGGTTCPVCRTLIKFLLQYFNQDEITSESTEKSDVSNFVKYYNRRYSGMSVSVIDQIRDFPTILRNGIWRI-IQGDFNFAFRMRIIIVIAGMVLYVLSPLDILPEFLFGIFGFVDDIAAIFLTLSYLNYLFRR 1271
            F+  Y L        QE L+   N++       H +    CPVCL+     ++T+C H+FCG CL+ +     + G  +CP+CR  +  L   F +++    S    D+ + +++YN R+SG    V D + D P++L  G+ RI   G   + F +RI++ + G+V+   +P D++P+ + GI   +DD+  +FL LS +  +F++
Sbjct:    3 FSCGYKLDMNSPKPEQEKLSLTNNKDSYKCRQSHFDNDLNCPVCLQTATMPVETNCGHLFCGSCLMTYWKHDPWLGAMSCPLCRQKVVLLYNDFWENQADKLS---RDIVHDIRHYNNRFSGKPRPVTDYLYDMPSLLHLGLRRIFTMGGLVWVFCLRILVCLFGVVVCFSTPFDVIPDPMCGILSIIDDLVVVFLLLSCIINIFQQ 206

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BLAST of E3 ubiquitin-protein ligase RNF170 vs. Ensembl Xenopus
Match: hmgb2 (high mobility group box 2 [Source:NCBI gene;Acc:394499])

HSP 1 Score: 72.4034 bits (176), Expect = 4.597e-14
Identity = 36/74 (48.65%), Postives = 49/74 (66.22%), Query Frame = 2

Query:   20 DPNKPKGAWTAFFFFSDEHRKKIKEENPEYKVGDVAKVLGKMW--EACKDKSKYEEQAKRDKERYNKELEEYKS 235
            DPN PK   +AFF F  EHR +IK E+P   +GD AK LG+MW  +  KDK  YE++A + KE+Y K++  YK+
Sbjct:   92 DPNAPKRPPSAFFLFCSEHRPQIKSESPGLSIGDTAKKLGEMWSEQTPKDKLPYEQKAAKLKEKYEKDVAAYKA 165

HSP 2 Score: 47.7506 bits (112), Expect = 9.802e-6
Identity = 27/74 (36.49%), Postives = 48/74 (64.86%), Query Frame = 2

Query:   20 DPNKPKGAWTAFFFFSDEHRKKIKEENPEYKV--GDVAKVLGKMWE--ACKDKSKYEEQAKRDKERYNKELEEY 229
            DPNKP+G  +++ +F    R++ K+++P+  V   + +K   + W+  + K+KSK+EE AK DK RY +E++ Y
Sbjct:    5 DPNKPRGKMSSYAYFVQTCREEHKKKHPDSSVNFAEFSKKCSERWKTMSAKEKSKFEEMAKNDKVRYEREMKTY 78

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BLAST of E3 ubiquitin-protein ligase RNF170 vs. Ensembl Xenopus
Match: cep170b (centrosomal protein 170B [Source:Xenbase;Acc:XB-GENE-5943417])

HSP 1 Score: 71.2478 bits (173), Expect = 1.150e-13
Identity = 38/80 (47.50%), Postives = 51/80 (63.75%), Query Frame = 2

Query:    2 NKRKIKDPNKPKGAWTAFFFFSDEHRKKIKEENPEYKVGDVAKVLGKMW--EACKDKSKYEEQAKRDKERYNKELEEYKS 235
             K+K KDPN PK   +AFF F  E R KIK E+P   +GD+AK LG+MW   A  DK  YE +A + KE+Y K++  Y++
Sbjct:   85 TKKKFKDPNAPKRPPSAFFLFCSEFRPKIKGEHPGSTIGDIAKKLGEMWNNTATDDKLPYERKAAKLKEKYEKDVAAYRA 164

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BLAST of E3 ubiquitin-protein ligase RNF170 vs. Ensembl Mouse
Match: Rnf170 (ring finger protein 170 [Source:MGI Symbol;Acc:MGI:1924983])

HSP 1 Score: 139.813 bits (351), Expect = 3.521e-38
Identity = 75/218 (34.40%), Postives = 121/218 (55.50%), Query Frame = 3

Query:  657 SLINRFNSSYNLHSTYEIQYQEFLNQARNENIHSNAPNR--------CPVCLEGCKYSIKTSCSHMFCGQCLIGWSNTVNFPGGTTCPVCRTLIKFLLQYFNQDEITSESTE-KSDVSNFVKYYNRRYSGMSVSVIDQIRDFPTILRNGIWRIIQ-GDFNFAFRMRIIIVIAGMVLYVLSPLDILPEFLFGIFGFVDDIAAIFLTLSYLNYLFRRSLT 1280
            S I R N   N+H   +   +    Q + E     AP R        CP+CL    + ++T+C H+FCG C+I +    ++ G  +CP+CR  +  LL  F +D+ + +    + DV++    YNRR+SG   S++++I D PT+LR+    +   G   + FR+RI++ + G   Y++SPLD +PE LFGI GF+DD   IFL L Y++ ++R  +T
Sbjct:   23 SWIQR-NVQQNIHPENQELVRVLREQFQTEQ-DVPAPARQQFYTEMYCPICLHQASFPVETNCGHLFCGSCIIAYWRYGSWLGAISCPICRQTVTLLLTVFGEDDQSQDVIRLRQDVND----YNRRFSGQPRSIMERIMDLPTLLRHAFREVFSVGGLFWMFRIRIMLCLMGAFFYLISPLDFVPEALFGILGFLDDFFVIFLLLIYISIMYREVIT 234

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BLAST of E3 ubiquitin-protein ligase RNF170 vs. Ensembl Mouse
Match: Rnf170 (ring finger protein 170 [Source:MGI Symbol;Acc:MGI:1924983])

HSP 1 Score: 139.043 bits (349), Expect = 2.149e-37
Identity = 72/212 (33.96%), Postives = 118/212 (55.66%), Query Frame = 3

Query:  675 NSSYNLHSTYEIQYQEFLNQARNENIHSNAPNR--------CPVCLEGCKYSIKTSCSHMFCGQCLIGWSNTVNFPGGTTCPVCRTLIKFLLQYFNQDEITSESTE-KSDVSNFVKYYNRRYSGMSVSVIDQIRDFPTILRNGIWRIIQ-GDFNFAFRMRIIIVIAGMVLYVLSPLDILPEFLFGIFGFVDDIAAIFLTLSYLNYLFRRSLT 1280
            N   N+H   +   +    Q + E     AP R        CP+CL    + ++T+C H+FCG C+I +    ++ G  +CP+CR  +  LL  F +D+ + +    + DV++    YNRR+SG   S++++I D PT+LR+    +   G   + FR+RI++ + G   Y++SPLD +PE LFGI GF+DD   IFL L Y++ ++R  +T
Sbjct:   75 NVQQNIHPENQELVRVLREQFQTEQ-DVPAPARQQFYTEMYCPICLHQASFPVETNCGHLFCGSCIIAYWRYGSWLGAISCPICRQTVTLLLTVFGEDDQSQDVIRLRQDVND----YNRRFSGQPRSIMERIMDLPTLLRHAFREVFSVGGLFWMFRIRIMLCLMGAFFYLISPLDFVPEALFGILGFLDDFFVIFLLLIYISIMYREVIT 281

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BLAST of E3 ubiquitin-protein ligase RNF170 vs. Ensembl Mouse
Match: Rnf170 (ring finger protein 170 [Source:MGI Symbol;Acc:MGI:1924983])

HSP 1 Score: 107.457 bits (267), Expect = 3.595e-26
Identity = 48/139 (34.53%), Postives = 84/139 (60.43%), Query Frame = 3

Query:  774 CPVCLEGCKYSIKTSCSHMFCGQCLIGWSNTVNFPGGTTCPVCRTLIKFLLQYFNQDEITSESTE-KSDVSNFVKYYNRRYSGMSVSVIDQIRDFPTILRNGIWRIIQ-GDFNFAFRMRIIIVIAGMVLYVLSPLDILP 1184
            CP+CL    + ++T+C H+FCG C+I +    ++ G  +CP+CR  +  LL  F +D+ + +    + DV++    YNRR+SG   S++++I D PT+LR+    +   G   + FR+RI++ + G   Y++SPLD +P
Sbjct:  115 CPICLHQASFPVETNCGHLFCGSCIIAYWRYGSWLGAISCPICRQTVTLLLTVFGEDDQSQDVIRLRQDVND----YNRRFSGQPRSIMERIMDLPTLLRHAFREVFSVGGLFWMFRIRIMLCLMGAFFYLISPLDFVP 249

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BLAST of E3 ubiquitin-protein ligase RNF170 vs. Ensembl Mouse
Match: Hmgb1 (high mobility group box 1 [Source:MGI Symbol;Acc:MGI:96113])

HSP 1 Score: 67.0106 bits (162), Expect = 2.674e-12
Identity = 39/80 (48.75%), Postives = 53/80 (66.25%), Query Frame = 2

Query:    2 NKRKIKDPNKPKGAWTAFFFFSDEHRKKIKEENPEYKVGDVAKVLGKMW--EACKDKSKYEEQAKRDKERYNKELEEYKS 235
             K+K KDPN PK   +AFF F  E+R KIK E+P   +GDVAK LG+MW   A  DK  YE++A + KE+Y K++  Y++
Sbjct:   99 TKKKFKDPNAPKRPPSAFFLFCSEYRPKIKGEHPGLSIGDVAKKLGEMWNNTAADDKQPYEKKAAKLKEKYEKDIAAYRA 178

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BLAST of E3 ubiquitin-protein ligase RNF170 vs. Ensembl Mouse
Match: Hmgb1 (high mobility group box 1 [Source:MGI Symbol;Acc:MGI:96113])

HSP 1 Score: 66.6254 bits (161), Expect = 3.942e-12
Identity = 39/80 (48.75%), Postives = 53/80 (66.25%), Query Frame = 2

Query:    2 NKRKIKDPNKPKGAWTAFFFFSDEHRKKIKEENPEYKVGDVAKVLGKMW--EACKDKSKYEEQAKRDKERYNKELEEYKS 235
             K+K KDPN PK   +AFF F  E+R KIK E+P   +GDVAK LG+MW   A  DK  YE++A + KE+Y K++  Y++
Sbjct:   85 TKKKFKDPNAPKRPPSAFFLFCSEYRPKIKGEHPGLSIGDVAKKLGEMWNNTAADDKQPYEKKAAKLKEKYEKDIAAYRA 164

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BLAST of E3 ubiquitin-protein ligase RNF170 vs. UniProt/SwissProt
Match: sp|Q28DS3|RN170_XENTR (E3 ubiquitin-protein ligase RNF170 OS=Xenopus tropicalis OX=8364 GN=rnf170 PE=2 SV=1)

HSP 1 Score: 142.124 bits (357), Expect = 5.874e-38
Identity = 70/213 (32.86%), Postives = 118/213 (55.40%), Query Frame = 3

Query:  675 NSSYNLHSTYEIQYQEFLNQARNENIHSNAPN-------RCPVCLEGCKYSIKTSCSHMFCGQCLIGWSNTVNFPGGTTCPVCRTLIKFLLQYFNQDEITSESTEKSDVSNFVKY---YNRRYSGMSVSVIDQIRDFPTILRNGIWRIIQ-GDFNFAFRMRIIIVIAGMVLYVLSPLDILPEFLFGIFGFVDDIAAIFLTLSYLNYLFRRSLT 1280
            N   N+H   + + +    Q +NE      P         CPVCL+   + ++T+C H+FCG C+I +    ++ G   CP+CR  +  +   F       ++TE+ D  N ++    YNRR+SG   S++D+I D PT+LR+    +   G   + FR+RI++ + G + Y++SPLDI+PE +FG+ GF+DD   +FL L Y++ ++R  +T
Sbjct:   47 NDEQNIHPENQDRVRAVREQLQNEQETPPPPRPQFYSDMTCPVCLQQATFPVETNCGHLFCGSCIIAYWRYGSWLGAINCPICRQTVTLIFPLF-------QATEQEDSQNILREAIGYNRRFSGQPRSLMDRIMDLPTLLRHAFREMFSVGGLFWMFRIRIVLCLLGALFYLVSPLDIIPEAVFGLLGFLDDFFVLFLLLIYISIMYREVVT 252

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BLAST of E3 ubiquitin-protein ligase RNF170 vs. UniProt/SwissProt
Match: sp|Q96K19|RN170_HUMAN (E3 ubiquitin-protein ligase RNF170 OS=Homo sapiens OX=9606 GN=RNF170 PE=1 SV=2)

HSP 1 Score: 141.739 bits (356), Expect = 7.342e-38
Identity = 71/210 (33.81%), Postives = 116/210 (55.24%), Query Frame = 3

Query:  687 NLHSTYEIQYQEFLNQARNE-NIHSNAPNR----------CPVCLEGCKYSIKTSCSHMFCGQCLIGWSNTVNFPGGTTCPVCRTLIKFLLQYFNQDEITSESTEKSDVSNFVKYYNRRYSGMSVSVIDQIRDFPTILRNGIWRIIQ-GDFNFAFRMRIIIVIAGMVLYVLSPLDILPEFLFGIFGFVDDIAAIFLTLSYLNYLFRRSLT 1280
            N+H     + QE +   R +     +AP            CP+CL    + ++T+C H+FCG C+I +    ++ G  +CP+CR  +  LL  F +D+   +S +   +   +  YNRR+SG   S++++I D PT+LR+    +   G   + FR+RII+ + G   Y++SPLD +PE LFGI GF+DD   IFL L Y++ ++R  +T
Sbjct:   47 NVHQNIHPENQELVRVLREQLQTEQDAPAATRQQFYTDMYCPICLHQASFPVETNCGHLFCGACIIAYWRYGSWLGAISCPICRQTVTLLLTVFGEDD---QSQDVLRLHQDINDYNRRFSGQPRSIMERIMDLPTLLRHAFREMFSVGGLFWMFRIRIILCLMGAFFYLISPLDFVPEALFGILGFLDDFFVIFLLLIYISIMYREVIT 253

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BLAST of E3 ubiquitin-protein ligase RNF170 vs. UniProt/SwissProt
Match: sp|F1MK05|RN170_BOVIN (E3 ubiquitin-protein ligase RNF170 OS=Bos taurus OX=9913 GN=RNF170 PE=3 SV=2)

HSP 1 Score: 138.272 bits (347), Expect = 1.272e-36
Identity = 71/213 (33.33%), Postives = 116/213 (54.46%), Query Frame = 3

Query:  681 SYNLHSTYEIQYQEFLNQARNE-NIHSNAPNR----------CPVCLEGCKYSIKTSCSHMFCGQCLIGWSNTVNFPGGTTCPVCRTLIKFLLQYFNQDEITSESTE-KSDVSNFVKYYNRRYSGMSVSVIDQIRDFPTILRNGIWRIIQ-GDFNFAFRMRIIIVIAGMVLYVLSPLDILPEFLFGIFGFVDDIAAIFLTLSYLNYLFRRSLT 1280
            S N H     + QE +   R +     +AP            CP+CL      ++T+C H+FCG C++ +    ++ G  +CP+CR  +  LL  F +++ + +      D+S+    YNRR+SG   S++++I D PT+LR+    +   G   + FR+RII+ + G   Y++SPLD +PE LFGI GF+DD   IFL L Y++ ++R  +T
Sbjct:   46 SRNAHQNIHPENQELVRVLREQLQTEQDAPAAARQQFYTDMYCPICLHQASLPVETNCGHLFCGTCIVAYWRYGSWLGAISCPICRQTVTLLLPVFGENDQSQDVVSLHQDISD----YNRRFSGQPRSIMERIMDLPTLLRHAFREMFSVGGLFWMFRIRIILCLMGAFFYLISPLDFVPEALFGILGFLDDFFVIFLLLIYISIMYREVIT 254

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BLAST of E3 ubiquitin-protein ligase RNF170 vs. UniProt/SwissProt
Match: sp|Q8CBG9|RN170_MOUSE (E3 ubiquitin-protein ligase RNF170 OS=Mus musculus OX=10090 GN=Rnf170 PE=1 SV=1)

HSP 1 Score: 139.043 bits (349), Expect = 1.503e-36
Identity = 72/212 (33.96%), Postives = 118/212 (55.66%), Query Frame = 3

Query:  675 NSSYNLHSTYEIQYQEFLNQARNENIHSNAPNR--------CPVCLEGCKYSIKTSCSHMFCGQCLIGWSNTVNFPGGTTCPVCRTLIKFLLQYFNQDEITSESTE-KSDVSNFVKYYNRRYSGMSVSVIDQIRDFPTILRNGIWRIIQ-GDFNFAFRMRIIIVIAGMVLYVLSPLDILPEFLFGIFGFVDDIAAIFLTLSYLNYLFRRSLT 1280
            N   N+H   +   +    Q + E     AP R        CP+CL    + ++T+C H+FCG C+I +    ++ G  +CP+CR  +  LL  F +D+ + +    + DV++    YNRR+SG   S++++I D PT+LR+    +   G   + FR+RI++ + G   Y++SPLD +PE LFGI GF+DD   IFL L Y++ ++R  +T
Sbjct:   75 NVQQNIHPENQELVRVLREQFQTEQ-DVPAPARQQFYTEMYCPICLHQASFPVETNCGHLFCGSCIIAYWRYGSWLGAISCPICRQTVTLLLTVFGEDDQSQDVIRLRQDVND----YNRRFSGQPRSIMERIMDLPTLLRHAFREVFSVGGLFWMFRIRIMLCLMGAFFYLISPLDFVPEALFGILGFLDDFFVIFLLLIYISIMYREVIT 281

[Close]

BLAST of E3 ubiquitin-protein ligase RNF170 vs. UniProt/SwissProt
Match: sp|Q7SZN2|RN170_DANRE (E3 ubiquitin-protein ligase RNF170 OS=Danio rerio OX=7955 GN=rnf170 PE=2 SV=1)

HSP 1 Score: 132.494 bits (332), Expect = 2.905e-34
Identity = 64/213 (30.05%), Postives = 115/213 (53.99%), Query Frame = 3

Query:  675 NSSYNLHSTYEIQYQEFLNQARNENIHSNAPNR------CPVCLEGCKYSIKTSCSHMFCGQCLIGWSNTVNFPGGTTCPVCRTLIKFLLQYFNQDEITS----ESTEKSDVSNFVKYYNRRYSGMSVSVIDQIRDFPTILRNGIWRIIQ-GDFNFAFRMRIIIVIAGMVLYVLSPLDILPEFLFGIFGFVDDIAAIFLTLSYLNYLFRRSLT 1280
            +    +H   + + +    Q + E + S + ++      CPVCL+     ++T+C H+FCG C+I +     + G  +CP+CR ++  L   F   E ++       E + +   +  YNRR+SG   S++D++RD PT+LR+    +   G   + FR+RI++ + G + Y++SPLD LPE + G+ GF+DD   I L   Y++ ++R  +T
Sbjct:   49 SEQQRIHPESQERVRVVREQLQAEQVSSESRHQFYSDMSCPVCLQQAVLPVETNCGHLFCGSCIIAYWRYGTWLGAISCPICRQMVTLLFPLFQDSEQSAVAADSPVEPTLILTDISDYNRRFSGQPRSLLDRLRDVPTLLRHAFREMFSVGGLFWMFRVRILLCVCGALAYLVSPLDFLPEGVLGLLGFLDDFFVILLLFIYISIMYREVVT 261

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BLAST of E3 ubiquitin-protein ligase RNF170 vs. TrEMBL
Match: I1ZIJ2 (High mobility group-1 OS=Schmidtea mediterranea OX=79327 PE=2 SV=1)

HSP 1 Score: 198.364 bits (503), Expect = 8.485e-58
Identity = 97/97 (100.00%), Postives = 97/97 (100.00%), Query Frame = 2

Query:    2 NKRKIKDPNKPKGAWTAFFFFSDEHRKKIKEENPEYKVGDVAKVLGKMWEACKDKSKYEEQAKRDKERYNKELEEYKSGTPVSKKTKGAGDQVNGNH 292
            NKRKIKDPNKPKGAWTAFFFFSDEHRKKIKEENPEYKVGDVAKVLGKMWEACKDKSKYEEQAKRDKERYNKELEEYKSGTPVSKKTKGAGDQVNGNH
Sbjct:   83 NKRKIKDPNKPKGAWTAFFFFSDEHRKKIKEENPEYKVGDVAKVLGKMWEACKDKSKYEEQAKRDKERYNKELEEYKSGTPVSKKTKGAGDQVNGNH 179

[Close]

BLAST of E3 ubiquitin-protein ligase RNF170 vs. TrEMBL
Match: A0A0R3UNK5 (RING-type domain-containing protein OS=Mesocestoides corti OX=53468 GN=MCOS_LOCUS9383 PE=4 SV=1)

HSP 1 Score: 147.517 bits (371), Expect = 1.478e-37
Identity = 70/178 (39.33%), Postives = 108/178 (60.67%), Query Frame = 3

Query:  756 SNAPNRCPVCLEGCKYSIKTSCSHMFCGQCLIGWSNTVNFPGGTTCPVCRTLIKFLLQYFNQDEITSEST-EKSDVSNFVKYYNRRYSGMSVSVIDQIRDFPTILRNGIWRIIQGD-FNFAFRMRIIIVIAGMVLYVLSPLDILPEFLFGIFGFVDDIAAIFLTLSYLNYLFRRSLTT 1283
            + AP+ CP+CLEG  + I+T+C H FCG C   +    +      CPVCR  ++FL++ F  +EI +++T E+SDV + +  +NRRYSG  VS +DQ+RD P ++R G+  ++ GD  +   R+R+I++   +  YV+SPLDI PE + G FG +DD     +   Y+  LFR  L  
Sbjct:   73 ARAPDVCPICLEGITFGIETNCRHQFCGSCFCAYWQHTSPLAQPNCPVCRGQLRFLVKCFTPEEIQADATQERSDVESQIALFNRRYSGNPVSFLDQLRDLPALMRYGVRALLDGDGISCLLRLRLIVLSLFVFFYVVSPLDIFPESVVGAFGLLDDCLVCVVFFIYMAALFRGRLAA 250

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BLAST of E3 ubiquitin-protein ligase RNF170 vs. TrEMBL
Match: A0A2C9K1H4 (RING-type domain-containing protein OS=Biomphalaria glabrata OX=6526 GN=106077814 PE=4 SV=1)

HSP 1 Score: 145.591 bits (366), Expect = 6.745e-37
Identity = 75/201 (37.31%), Postives = 113/201 (56.22%), Query Frame = 3

Query:  678 SSYNLHSTYEIQYQEFLNQ---ARNENIHSNAPNRCPVCLEGCKYSIKTSCSHMFCGQCLIGWSNTVNFPGGTTCPVCRTLIKFLLQYFNQDEITSESTEKSDVSNFVKYYNRRYSGMSVSVIDQIRDFPTILRNGIWRIIQ-GDFNFAFRMRIIIVIAGMVLYVLSPLDILPEFLFGIFGFVDDIAAIFLTLSYLNYLFR 1268
             S+N  +T   Q Q    Q    R  N  ++   +CP+CL    ++I+T+C H+FCG C+I +     + G   CP CRT +  LL  F  +E   ES E+ +V   V  YNRRYSG + ++ + ++D PT+LR+        G   + FR+RI+I++    +Y++SPLDILPE  FGI GF+DDI  I     Y++ L+R
Sbjct:   48 DSFNNVATTREQLQTEGGQRGSQRRANHANDGSLQCPICLGSAAFAIETNCGHVFCGHCMITYWEHQTWLGAVRCPSCRTQVSLLLLNFTSEEHAHESDERREVITKVNQYNRRYSGEARTIQEYLQDLPTLLRHTFHEFFSIGGLMWMFRLRIVILVIAAFVYLVSPLDILPEGAFGIIGFLDDIFIILFIAVYISVLYR 248

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BLAST of E3 ubiquitin-protein ligase RNF170 vs. TrEMBL
Match: A0A4W3K3X3 (RING-type domain-containing protein OS=Callorhinchus milii OX=7868 GN=rnf170 PE=4 SV=1)

HSP 1 Score: 145.976 bits (367), Expect = 7.498e-37
Identity = 73/214 (34.11%), Postives = 118/214 (55.14%), Query Frame = 3

Query:  675 NSSYNLHSTYEIQYQEFLNQARNENI-HSNAPNR----------CPVCLEGCKYSIKTSCSHMFCGQCLIGWSNTVNFPGGTTCPVCRTLIKFLLQYFNQDEITSESTEKSDVSNFVKYYNRRYSGMSVSVIDQIRDFPTILRNGIWRIIQ-GDFNFAFRMRIIIVIAGMVLYVLSPLDILPEFLFGIFGFVDDIAAIFLTLSYLNYLFRRSLT 1280
            N   N+H   + + +E     + E + H +AP +          CPVCL+   + ++T+C H+FCG C+I +     + G   CP+CR ++  L   F  ++   +  E   +   +  YNRR+SG   S +D+I D PT+LR+    +   G   + FR+RI++ +AG + Y+ SPLD LPE LFGI GF+DD+  IFL L Y++ ++R  +T
Sbjct:   47 NEQQNIHPENQERVRELRQHLQAEALNHQDAPAQDRQLFYTDMSCPVCLQQAAFPVETNCGHLFCGSCIIAYWRYGTWLGAVNCPICRQMVTLLFPLFPVND--QQLPESMQIIQEINNYNRRFSGQPRSWMDRIMDLPTLLRHAFTELFTIGGLFWMFRIRILLCLAGALFYLASPLDFLPEALFGILGFLDDLFVIFLLLIYISIMYREVVT 258

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BLAST of E3 ubiquitin-protein ligase RNF170 vs. TrEMBL
Match: G3SSU1 (Ring finger protein 170 OS=Loxodonta africana OX=9785 GN=RNF170 PE=4 SV=1)

HSP 1 Score: 144.436 bits (363), Expect = 1.991e-36
Identity = 72/211 (34.12%), Postives = 118/211 (55.92%), Query Frame = 3

Query:  675 NSSYNLHSTYEIQYQEFLNQARNENIHSNAPNR-------CPVCLEGCKYSIKTSCSHMFCGQCLIGWSNTVNFPGGTTCPVCRTLIKFLLQYFNQDEITSESTE-KSDVSNFVKYYNRRYSGMSVSVIDQIRDFPTILRNGIWRIIQ-GDFNFAFRMRIIIVIAGMVLYVLSPLDILPEFLFGIFGFVDDIAAIFLTLSYLNYLFRRSLT 1280
            N+  N+H   +   +E   Q + E   + A  +       CP+CL    + ++T+C H+FCG C+I +     + G  +CP+CR  +  LL  F  D+ T +    + D+++    YNRR+SG   S++++I D PT+LR+    +   G   + FR+RII+ + G   Y++SPLD +PE LFGI GF+DD   IFL L Y++ ++R  +T
Sbjct:   50 NAHQNIHPENQELVRELREQLQTEQDATAAARQQFYTDMYCPICLHQASFPVETNCGHLFCGTCIIAYWRYGTWLGAISCPICRQTVTLLLTVFGDDDQTQDVVRLRQDIND----YNRRFSGQPRSILERIMDLPTLLRHAFREMFSVGGLFWMFRVRIILCLMGAFFYLISPLDFVPEALFGILGFLDDFFVIFLLLIYISIMYREVIT 256

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BLAST of E3 ubiquitin-protein ligase RNF170 vs. Ensembl Cavefish
Match: rnf170 (ring finger protein 170 [Source:NCBI gene;Acc:406612])

HSP 1 Score: 122.865 bits (307), Expect = 5.621e-32
Identity = 61/170 (35.88%), Postives = 97/170 (57.06%), Query Frame = 3

Query:  774 CPVCLEGCKYSIKTSCSHMFCGQCLIGWSNTVNFPGGTTCPVCRTLIKFLLQYFNQDEITSESTEKSDVSNFVKYYNRRYSGMSVSVIDQIRDFPTILRNGIWRIIQ-GDFNFAFRMRIIIVIAGMVLYVLSPLDILPEFLFGIFGFVDDIAAIFLTLSYLNYLFRRSLT 1280
            CPVCL+     ++T+C H+FCG C+I +     + G  +CP+CR + + L                 DV++    YNRR+SG   S++D++RD PT+LR+    +   G   + FR+RII+ + G + Y+ SPLD +PE LFG+ GF+DD   I L   Y++ ++R  +T
Sbjct:   85 CPVCLQQAVLPVETNCGHLFCGSCIIAYWRYGTWLGAISCPICRQMTQRLFW--------------GDVND----YNRRFSGQPRSLLDRLRDVPTLLRHAFREMFSVGGLFWMFRIRIILCLVGALTYLASPLDFIPEALFGLLGFMDDFFVILLLFIYISIMYREVVT 236

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BLAST of E3 ubiquitin-protein ligase RNF170 vs. Ensembl Cavefish
Match: si:dkey-183n20.15 (E3 ubiquitin-protein ligase RNF170-like [Source:NCBI gene;Acc:103034427])

HSP 1 Score: 90.8929 bits (224), Expect = 1.291e-20
Identity = 55/188 (29.26%), Postives = 92/188 (48.94%), Query Frame = 3

Query:  696 STYEIQYQEFLNQARNENIHSNAPNR---CPVCLEGCKYSIKTSCSHMFCGQCLIGWSNTVNFPGGTTCPVCRTLIKFLLQYFNQDEITSESTEKSDVSNFVKYYNRRYSGMSVSVIDQIRDFPTILRNGIWRII--QGDFNFAFRMRIIIVIAGMVLYVLSPLDILPEFLFGIFGFVDDIAAIFLTL 1244
            S  + Q Q   N   +      A NR   CPVCL+   + ++T+C H+FC  CLI +    ++    +CP+CR  +  +   F +  +  + TE   V + ++ YN+RYSG    + D + D P  L   I+R +   G   + F +R+ +   G    ++SPL+ +     G  G +DD+A +FL L
Sbjct:   19 SQGQPQGQHVRNGEDSSQSCVTAANRDLHCPVCLQSSIFPVETNCGHLFCAPCLISYWKHGSWLDAISCPLCRQKVSVMSHLFGEGRLDRKQTE---VLDHIRDYNKRYSGAPRRLSDYLCDAPLFLLL-IFRTLGNMGGLVWLFLLRVAVCGFGAAASLVSPLEAVSGPFNGAVGLLDDLAVVFLLL 202

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BLAST of E3 ubiquitin-protein ligase RNF170 vs. Ensembl Cavefish
Match: ENSAMXT00000044228.1 (high mobility group protein B2-like [Source:NCBI gene;Acc:103034313])

HSP 1 Score: 76.2554 bits (186), Expect = 1.477e-15
Identity = 38/88 (43.18%), Postives = 57/88 (64.77%), Query Frame = 2

Query:    8 RKIKDPNKPKGAWTAFFFFSDEHRKKIKEENPEYKVGDVAKVLGKMWE--ACKDKSKYEEQAKRDKERYNKELEEYKSGTPVSKKTKG 265
            RK KDPN PK   +AFF F  EHR  +K E+P   +G++AK LG+ W   + KD+S ++++A   +E+Y KE+  Y+SG  V+K+  G
Sbjct:   88 RKKKDPNAPKRPPSAFFIFCSEHRPAVKSEHPNLTIGEIAKKLGEKWSKLSTKDRSPFDQKAVLLREKYEKEVAAYRSGGSVAKRGPG 175

HSP 2 Score: 48.1358 bits (113), Expect = 5.729e-6
Identity = 29/76 (38.16%), Postives = 47/76 (61.84%), Query Frame = 2

Query:   14 IKDPNKPKGAWTAFFFFSDEHRKKIKEENPEYKV--GDVAKVLGKMWEAC--KDKSKYEEQAKRDKERYNKELEEY 229
            +KD NKPKG  +A+ FF    R ++K+++P   V  G  +K   + W+A    +K K+E+ AK DK RY++E++ Y
Sbjct:    2 VKDANKPKGRTSAYAFFVLSSRDELKKKSPGTSVNFGKFSKKCSEDWKALTPSEKKKFEDLAKADKARYDEEMKSY 77

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BLAST of E3 ubiquitin-protein ligase RNF170 vs. Ensembl Cavefish
Match: hmgb2a (high mobility group box 2 [Source:NCBI gene;Acc:111195933])

HSP 1 Score: 72.7886 bits (177), Expect = 1.794e-14
Identity = 34/74 (45.95%), Postives = 52/74 (70.27%), Query Frame = 2

Query:   20 DPNKPKGAWTAFFFFSDEHRKKIKEENPEYKVGDVAKVLGKMW--EACKDKSKYEEQAKRDKERYNKELEEYKS 235
            DPN PK   +AFF F  +HR K+K E+P   +GD+AK LG+MW  ++ KDK+ YE++A + KE+Y K++  Y++
Sbjct:   91 DPNAPKRPPSAFFVFCSDHRPKVKSEHPGISIGDIAKKLGEMWSKQSPKDKAPYEQKAMKLKEKYEKDVAAYRA 164

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BLAST of E3 ubiquitin-protein ligase RNF170 vs. Ensembl Cavefish
Match: hmgb1a (high mobility group-T protein-like [Source:NCBI gene;Acc:103039534])

HSP 1 Score: 65.4698 bits (158), Expect = 5.617e-12
Identity = 38/83 (45.78%), Postives = 55/83 (66.27%), Query Frame = 2

Query:    5 KRKIKDPNKPKGAWTAFFFFSDEHRKKIKEENPEYKVGDVAKVLGKMW--EACKDKSKYEEQAKRDKERYNKELEEYKSGTPV 247
            K++ KDPN PK   +AFF F  E+R K+KEE P   +GDVAK LG+MW   + ++K  YE++A + KE+Y K++  Y+ G  V
Sbjct:   85 KKRFKDPNAPKRPPSAFFIFCAEYRPKVKEETPGLSIGDVAKKLGEMWNKTSAEEKQPYEKKAAKLKEKYEKDIAAYRKGKVV 167

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BLAST of E3 ubiquitin-protein ligase RNF170 vs. Ensembl Sea Lamprey
Match: hmgb2b (high mobility group box 2b [Source:ZFIN;Acc:ZDB-GENE-040912-122])

HSP 1 Score: 68.1662 bits (165), Expect = 1.611e-13
Identity = 38/90 (42.22%), Postives = 56/90 (62.22%), Query Frame = 2

Query:    8 RKIKDPNKPKGAWTAFFFFSDEHRKKIKEENPEYKVGDVAKVLGKMW--EACKDKSKYEEQAKRDKERYNKELEEYKSGTPVSKKTKGAG 271
            RK KDPN PK   +AFF +  E+R K++ ENP   +G +AK LG+MW      +KS YE +  + KE+Y+K++  Y+S   V + +KGA 
Sbjct:   88 RKKKDPNAPKRPPSAFFIYCAEYRSKVRAENPGLTIGSIAKKLGEMWNNAPADEKSIYERKTAKLKEKYDKDMASYRSKGKV-ETSKGAS 176

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BLAST of E3 ubiquitin-protein ligase RNF170 vs. Ensembl Sea Lamprey
Match: hmgb2a (high mobility group box 2a [Source:ZFIN;Acc:ZDB-GENE-051120-126])

HSP 1 Score: 62.3882 bits (150), Expect = 1.044e-11
Identity = 36/79 (45.57%), Postives = 52/79 (65.82%), Query Frame = 2

Query:    2 NKRKIKDPNKPKGAWTAFFFFSDEHRKKIKEENPEYKVGDVAKVLGKMWEAC--KDKSKYEEQAKRDKERYNKELEEYK 232
             KRK KDPN PK   +AFF F  EHR K+K ++P   +G++AK LG+MW     + KS YE++A + KE+Y K++  Y+
Sbjct:   83 GKRKTKDPNAPKRPPSAFFVFCSEHRPKVKADHPGLGIGEIAKRLGEMWGLLTPETKSPYEKKAAKLKEKYEKDVAAYR 161

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BLAST of E3 ubiquitin-protein ligase RNF170 vs. Ensembl Sea Lamprey
Match: ENSPMAT00000004052.1 (pep scaffold:Pmarinus_7.0:GL476375:218436:246333:-1 gene:ENSPMAG00000003679.1 transcript:ENSPMAT00000004052.1 gene_biotype:protein_coding transcript_biotype:protein_coding)

HSP 1 Score: 46.595 bits (109), Expect = 8.242e-6
Identity = 22/74 (29.73%), Postives = 43/74 (58.11%), Query Frame = 2

Query:   20 DPNKPKGAWTAFFFFSDEHRKKIKEENPEYKVGDVAKVLGKMWEACKDKSK--YEEQAKRDKERYNKELEEYKS 235
            DPN+P+   +A+  F  + +  IK +NP    G+V+K++  MW+   ++ K  Y+ + +  K+ Y K+L  Y++
Sbjct:  205 DPNEPQKPVSAYALFFRDTQAAIKGQNPSATFGEVSKIVASMWDGLGEEQKQAYKRRTEAAKKEYLKQLAAYRA 278

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BLAST of E3 ubiquitin-protein ligase RNF170 vs. Ensembl Yeast
Match: NHP6B (High-mobility group (HMG) protein; binds to and remodels nucleosomes; involved in recruiting FACT and other chromatin remodelling complexes to the chromosomes; functionally redundant with Nhp6Ap; required for transcriptional initiation fidelity of some tRNA genes; homologous to mammalian HMGB1 and HMGB2; NHP6B has a paralog, NHP6A, that arose from the whole genome duplication [Source:SGD;Acc:S000002157])

HSP 1 Score: 67.0106 bits (162), Expect = 2.359e-14
Identity = 32/78 (41.03%), Postives = 51/78 (65.38%), Query Frame = 2

Query:    8 RKIKDPNKPKGAWTAFFFFSDEHRKKIKEENPEYKVGDVAKVLGKMWEA--CKDKSKYEEQAKRDKERYNKELEEYKS 235
            R+ KDPN PK   +A+ FF++E+R  ++ ENP+   G V ++LG+ W+A   ++K  YE +A+ DK+RY  E E Y +
Sbjct:   19 RRKKDPNAPKRGLSAYMFFANENRDIVRSENPDVTFGQVGRILGERWKALTAEEKQPYESKAQADKKRYESEKELYNA 96

[Close]

BLAST of E3 ubiquitin-protein ligase RNF170 vs. Ensembl Yeast
Match: NHP6A (High-mobility group (HMG) protein; binds to and remodels nucleosomes; involved in recruiting FACT and other chromatin remodelling complexes to chromosomes; functionally redundant with Nhp6Bp; required for transcriptional initiation fidelity of some tRNA genes; homologous to mammalian HMGB1 and HMGB2; NHP6A has a paralog, NHP6B, that arose from the whole genome duplication; protein abundance increases in response to DNA replication stress [Source:SGD;Acc:S000006256])

HSP 1 Score: 63.1586 bits (152), Expect = 4.486e-13
Identity = 32/74 (43.24%), Postives = 48/74 (64.86%), Query Frame = 2

Query:   20 DPNKPKGAWTAFFFFSDEHRKKIKEENPEYKVGDVAKVLGKMWEAC--KDKSKYEEQAKRDKERYNKELEEYKS 235
            DPN PK A +A+ FF++E+R  ++ ENP+   G V K LG+ W+A   ++K  YE +A+ DK+RY  E E Y +
Sbjct:   17 DPNAPKRALSAYMFFANENRDIVRSENPDITFGQVGKKLGEKWKALTPEEKQPYEAKAQADKKRYESEKELYNA 90

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BLAST of E3 ubiquitin-protein ligase RNF170 vs. Ensembl Nematostella
Match: EDO34494 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7SP78])

HSP 1 Score: 102.064 bits (253), Expect = 1.317e-24
Identity = 66/211 (31.28%), Postives = 104/211 (49.29%), Query Frame = 3

Query:  639 ILHCLISLINRFNSSYNLHSTYEIQYQEF-------------LNQARNENIHSNAPN---------RCPVCLEGCKYSIKTSCSHMFCGQCLIGWSNTVNFPGGTTCPVCRTLIKFLLQYFNQDEITSESTEKSDVSNFVKYYNRRYSGMSVSVIDQIRDFPTILRNGIWRIIQ-GDFNFAFRMRIIIVIAGMVLYVLSPLDILPEFLFGI 1202
            IL  ++SLI  +NS + + + + +Q ++                Q  NE     AP          +CPVC+   ++   T+C H FC  C+I +     + G   CPVCR  +  L   F+ +E +S+ + +      +  YNRR+SG+  SV++ +RD PT+LR     +   G   +  RMRII+      LY +SPLDI+PE +FGI
Sbjct:   35 ILIAIVSLI--YNSHFRMLNIHPLQAEQVRLARDWLGIGTGGTEQDNNERDEIQAPEPPRAFSNDRQCPVCITDARFLTMTNCGHEFCAPCIITYWRHGRWLGAVQCPVCRQQVNLLFANFSSEESSSDDSHQW--RGEINEYNRRFSGLPRSVMEHLRDLPTLLRQLFSELFSVGGLVWVLRMRIILCFFAAALYFISPLDIIPESVFGI 241

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BLAST of E3 ubiquitin-protein ligase RNF170 vs. Ensembl Nematostella
Match: EDO41032 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7S5L8])

HSP 1 Score: 69.707 bits (169), Expect = 1.990e-13
Identity = 33/74 (44.59%), Postives = 47/74 (63.51%), Query Frame = 2

Query:   17 KDPNKPKGAWTAFFFFSDEHRKKIKEENPEYKVGDVAKVLGKMWEAC--KDKSKYEEQAKRDKERYNKELEEYK 232
            KD N PK   T +  F +EHR+K++ ENP+    +V ++LG MW       K  + E+A++DKERY KELEEY+
Sbjct:   10 KDVNAPKAPLTGYVRFLNEHREKVRSENPDLPFHEVTRILGNMWSQLPTPQKQLFLEEAEKDKERYMKELEEYQ 83

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BLAST of E3 ubiquitin-protein ligase RNF170 vs. Ensembl Nematostella
Match: EDO36028 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7SJW6])

HSP 1 Score: 65.4698 bits (158), Expect = 1.392e-12
Identity = 34/83 (40.96%), Postives = 53/83 (63.86%), Query Frame = 2

Query:   20 DPNKPKGAWTAFFFFSDEHRKKIKEENPEYKVGDVAKVLGKMWEACK--DKSKYEEQAKRDKERYNKELEEYKSGTPVSKKTK 262
            DPNKPK   +A+F F +  R  +K++NP    G ++KVLG+MW      DK++Y++ AK+DK RY  E++ +K G   +K+ K
Sbjct:   89 DPNKPKRCLSAYFHFINLKRDDVKKDNPNASGGALSKVLGEMWSKMTDDDKTQYQDMAKKDKVRYESEMKAFKDGKLPAKQNK 171

HSP 2 Score: 47.7506 bits (112), Expect = 1.666e-6
Identity = 24/70 (34.29%), Postives = 46/70 (65.71%), Query Frame = 2

Query:   26 NKPKGAWTAFFFFSDEHRKKIKEENPEYKVGDVAKVLGKMWEACKDKSK--YEEQAKRDKERYNKELEEY 229
            NKPKGA +A+ FF  + R+K++ E  ++ + D +KV  + W+   ++ K  + ++A +DKER+ +E++ Y
Sbjct:    1 NKPKGAKSAYNFFLQDQREKLQREEGKFSLADFSKVSAEKWKNMSEEEKETFVQKAGKDKERFKEEMQSY 70

[Close]

BLAST of E3 ubiquitin-protein ligase RNF170 vs. Ensembl Nematostella
Match: EDO47230 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7RMY4])

HSP 1 Score: 64.3142 bits (155), Expect = 1.284e-11
Identity = 31/78 (39.74%), Postives = 47/78 (60.26%), Query Frame = 2

Query:    5 KRKIKDPNKPKGAWTAFFFFSDEHRKKIKEENPEYKVGDVAKVLGKMWEACK--DKSKYEEQAKRDKERYNKELEEYK 232
            ++ ++D N PK   T +  F +E R+K++ E+PE    +V K+LG  W      DK +Y + A+RDKERY  ELE Y+
Sbjct:   12 RKTLRDTNAPKAPLTGYVQFLNEQREKVRSEHPELPFPEVTKILGAEWSKMSQDDKQRYLDDAERDKERYIIELENYQ 89

[Close]

BLAST of E3 ubiquitin-protein ligase RNF170 vs. Ensembl Nematostella
Match: EDO39305 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7SAG5])

HSP 1 Score: 59.3066 bits (142), Expect = 1.439e-11
Identity = 27/66 (40.91%), Postives = 48/66 (72.73%), Query Frame = 2

Query:   32 PKGAWTAFFFFSDEHRKKIKEENPEYKVGDVAKVLGKMWEACKDKSKYEEQAKRDKERYNKELEEY 229
            PK A +A+  + ++ R++IK++NP   V +V+KV G+MW+   DKSK+EE+A  +K++Y + ++EY
Sbjct:    1 PKRAMSAYMLWLNDTRQEIKDKNPGISVTEVSKVAGEMWKNLTDKSKWEEKAAIEKQKYVQRMKEY 66

[Close]

BLAST of E3 ubiquitin-protein ligase RNF170 vs. Ensembl Medaka
Match: rnf170 (E3 ubiquitin-protein ligase RNF170 [Source:NCBI gene;Acc:101162541])

HSP 1 Score: 133.65 bits (335), Expect = 1.002e-35
Identity = 78/249 (31.33%), Postives = 133/249 (53.41%), Query Frame = 3

Query:  576 IEGIENXXXXXXXXXXXCFLYILHCLISLINRFNSSYNLHSTYEIQYQ---EFLNQARNENIHSNAPNR------CPVCLEGCKYSIKTSCSHMFCGQCLIGWSNTVNFPGGTTCPVCRTLIKFLLQYFNQ----DEITSESTEKSDVSNFVKYYNRRYSGMSVSVIDQIRDFPTILRNGIWRIIQ-GDFNFAFRMRIIIVIAGMVLYVLSPLDILPEFLFGIFGFVDDIAAIFLTLSYLNYLFRRSLT 1280
            IEG+ N +L V++L     L  L  L++L+ R     N+H   +   +   + L   ++EN  + A  +      CPVCL+     ++T+C H+FCG C++ +     + G   CP+CR ++  L   F++      +     +   +   +  YNRR+SG   S++D++RD PT+LR+    +   G   + FR+RI++ + G + Y+ SPLDILPE LFG+ GF+DD   I L   Y++ ++R  +T
Sbjct:   20 IEGVSNQVLFVVVLS----LTFLAGLLTLLCR-QDEQNIHPENQEHVRAVRQQLQTEQDENPQAEARQQFYTDMSCPVCLQQAVLPVETNCGHLFCGSCIMAYWRYGTWLGAIHCPICRQIVTLLFPLFHEHAAPQRVQDGEAQPQLILRDINDYNRRFSGQPRSLMDRLRDVPTLLRHAFREMFSVGGLFWMFRIRILLCLVGALTYLASPLDILPEALFGLLGFMDDFFVILLLFVYISIMYREVVT 263

[Close]

BLAST of E3 ubiquitin-protein ligase RNF170 vs. Ensembl Medaka
Match: hmgb2a (high mobility group protein B2 [Source:NCBI gene;Acc:101157589])

HSP 1 Score: 75.0998 bits (183), Expect = 3.218e-15
Identity = 35/74 (47.30%), Postives = 52/74 (70.27%), Query Frame = 2

Query:   20 DPNKPKGAWTAFFFFSDEHRKKIKEENPEYKVGDVAKVLGKMW--EACKDKSKYEEQAKRDKERYNKELEEYKS 235
            DPN PK   +AFF F  +HR KIKE+NP   +GD+AK LG++W  ++ KDK+ YE +A + KE+Y K++  Y++
Sbjct:   91 DPNAPKRPPSAFFVFCSDHRPKIKEDNPGISIGDIAKKLGELWATQSAKDKAPYEAKAAKLKEKYEKDVAAYRA 164

[Close]

BLAST of E3 ubiquitin-protein ligase RNF170 vs. Ensembl Medaka
Match: si:dkey-183n20.15 (E3 ubiquitin-protein ligase RNF170 [Source:NCBI gene;Acc:101156315])

HSP 1 Score: 66.6254 bits (161), Expect = 3.887e-12
Identity = 39/138 (28.26%), Postives = 68/138 (49.28%), Query Frame = 3

Query:  771 RCPVCLEGCKYSIKTSCSHMFCGQCLIGWSNTVNFPGGTTCPVCRTLIKFLLQYFNQDEITSESTEKSDVSNFVKYYNRRYSGMSVSVIDQIRDFPTILR---NGIWRIIQGDFNFAFRMRIIIVIAGMVLYVLSPLD 1175
            +CPVCL+  ++ ++T+CSH+FC  CL+ +    ++     CP+CR  +  L   F +   +    +   V   +  YNRRYSG    + D + D P +L+    G+  +  G     F  R+ +   G V+ +  PL+
Sbjct:   53 QCPVCLQTPRFPVQTNCSHLFCAPCLLTYWRHGSWLDAINCPLCRQKVSVLCNLFYE---SQSDQQSQQVLGEITDYNRRYSGAPRKMKDYLCDVPLVLQLLARGLGAM--GGLVGLFLFRVALCCVGTVVSISVPLE 185

[Close]

BLAST of E3 ubiquitin-protein ligase RNF170 vs. Ensembl Medaka
Match: hmgb1a (high mobility group-T protein [Source:NCBI gene;Acc:101165167])

HSP 1 Score: 63.5438 bits (153), Expect = 2.735e-11
Identity = 36/78 (46.15%), Postives = 52/78 (66.67%), Query Frame = 2

Query:    8 RKIKDPNKPKGAWTAFFFFSDEHRKKIKEENPEYKVGDVAKVLGKMW--EACKDKSKYEEQAKRDKERYNKELEEYKS 235
            +K KDPN PK   +AFF F  E R K+K E+P   +GDVAK LG+MW   + +DK  YE++A + KE+Y K++  Y++
Sbjct:   86 KKFKDPNAPKRPPSAFFIFCSEFRPKVKGESPGLTIGDVAKRLGEMWNSTSAEDKQPYEKKAAKLKEKYGKDIAAYRA 163

[Close]

BLAST of E3 ubiquitin-protein ligase RNF170 vs. Ensembl Medaka
Match: hmgb1b (high mobility group protein B1 [Source:NCBI gene;Acc:101156596])

HSP 1 Score: 59.6918 bits (143), Expect = 4.672e-10
Identity = 34/79 (43.04%), Postives = 53/79 (67.09%), Query Frame = 2

Query:    5 KRKIKDPNKPKGAWTAFFFFSDEHRKKIKEENPEYKVGDVAKVLGKMW--EACKDKSKYEEQAKRDKERYNKELEEYKS 235
            K++ KDPN PK   +AFF F  + R KIK E+P   +GD AK LG+MW   + ++K  YE++A + KE+Y+K++  Y++
Sbjct:   85 KKRFKDPNAPKRPPSAFFLFCADFRPKIKSESPGLSIGDTAKKLGEMWNSSSAEEKQPYEKKAAKLKEKYDKDIVAYRT 163

[Close]

BLAST of E3 ubiquitin-protein ligase RNF170 vs. Planmine SMEST
Match: SMESG000068288.1 (SMESG000068288.1)

HSP 1 Score: 448.358 bits (1152), Expect = 5.655e-159
Identity = 218/219 (99.54%), Postives = 218/219 (99.54%), Query Frame = 3

Query:  627 CFLYILHCLISLINRFNSSYNLHSTYEIQYQEFLNQARNENIHSNAPNRCPVCLEGCKYSIKTSCSHMFCGQCLIGWSNTVNFPGGTTCPVCRTLIKFLLQYFNQDEITSESTEKSDVSNFVKYYNRRYSGMSVSVIDQIRDFPTILRNGIWRIIQGDFNFAFRMRIIIVIAGMVLYVLSPLDILPEFLFGIFGFVDDIAAIFLTLSYLNYLFRRSLTT 1283
            CFLYILHCLISLINRFN SYNLHSTYEIQYQEFLNQARNENIHSNAPNRCPVCLEGCKYSIKTSCSHMFCGQCLIGWSNTVNFPGGTTCPVCRTLIKFLLQYFNQDEITSESTEKSDVSNFVKYYNRRYSGMSVSVIDQIRDFPTILRNGIWRIIQGDFNFAFRMRIIIVIAGMVLYVLSPLDILPEFLFGIFGFVDDIAAIFLTLSYLNYLFRRSLTT
Sbjct:    4 CFLYILHCLISLINRFNISYNLHSTYEIQYQEFLNQARNENIHSNAPNRCPVCLEGCKYSIKTSCSHMFCGQCLIGWSNTVNFPGGTTCPVCRTLIKFLLQYFNQDEITSESTEKSDVSNFVKYYNRRYSGMSVSVIDQIRDFPTILRNGIWRIIQGDFNFAFRMRIIIVIAGMVLYVLSPLDILPEFLFGIFGFVDDIAAIFLTLSYLNYLFRRSLTT 222

[Close]

BLAST of E3 ubiquitin-protein ligase RNF170 vs. Planmine SMEST
Match: SMESG000068286.1 (SMESG000068286.1)

HSP 1 Score: 198.364 bits (503), Expect = 2.360e-61
Identity = 97/97 (100.00%), Postives = 97/97 (100.00%), Query Frame = 2

Query:    2 NKRKIKDPNKPKGAWTAFFFFSDEHRKKIKEENPEYKVGDVAKVLGKMWEACKDKSKYEEQAKRDKERYNKELEEYKSGTPVSKKTKGAGDQVNGNH 292
            NKRKIKDPNKPKGAWTAFFFFSDEHRKKIKEENPEYKVGDVAKVLGKMWEACKDKSKYEEQAKRDKERYNKELEEYKSGTPVSKKTKGAGDQVNGNH
Sbjct:   83 NKRKIKDPNKPKGAWTAFFFFSDEHRKKIKEENPEYKVGDVAKVLGKMWEACKDKSKYEEQAKRDKERYNKELEEYKSGTPVSKKTKGAGDQVNGNH 179

[Close]

BLAST of E3 ubiquitin-protein ligase RNF170 vs. Planmine SMEST
Match: SMESG000020771.1 (SMESG000020771.1)

HSP 1 Score: 123.25 bits (308), Expect = 8.104e-33
Identity = 58/87 (66.67%), Postives = 70/87 (80.46%), Query Frame = 2

Query:    5 KRKIKDPNKPKGAWTAFFFFSDEHRKKIKEENPEYKVGDVAKVLGKMWEACKDKSKYEEQAKRDKERYNKELEEYKSGTPVSKKTKG 265
            KR+ KDPNKPK   TAFFFFS+EHR+ +KE+NPE+KVGD+AKVLGKMW  CKDKSKYEE  K  KE+YN  + EYK+G P +KK+K 
Sbjct:   89 KREAKDPNKPKAPLTAFFFFSNEHRQTVKEKNPEFKVGDIAKVLGKMWSECKDKSKYEEMNKEAKEKYNLAMLEYKNGAPSAKKSKA 175

[Close]

BLAST of E3 ubiquitin-protein ligase RNF170 vs. Planmine SMEST
Match: SMESG000015032.1 (SMESG000015032.1)

HSP 1 Score: 123.25 bits (308), Expect = 2.760e-32
Identity = 65/198 (32.83%), Postives = 110/198 (55.56%), Query Frame = 3

Query:  687 NLHSTYEIQYQEFLNQARNENIHSNAPNRCPVCLEGCKYSIKTSCSHMFCGQCLIGWSNTVNFPGGTTCPVCRTLIKFLLQYFNQDEITSESTEKSDVSNFVKYYNRRYSGMSVSVIDQIRDFPTILRNGIWRIIQG-DFNFAFRMRIIIVIAGMVLYVLSPLDILPEFLFGIFGFVDDIAAIFLTLSYLNYLFRRSL 1277
            ++     I+ Q  ++ +RNE +       CP+CL+  ++ ++T+C H FCG C   + +  NF     CP+CRT +  L++ F+ +E  + S  K  + + +  +NR YS    + I+QI D P ILR+G   ++ G   +   R+RI ++   ++ Y LSPLDI+PE  FG+ G +DDI  +   L Y+   FRR++
Sbjct:   40 SVEDVSSIRDQISVSHSRNE-VEIYDSEICPICLDNFEFKVETNCGHEFCGSCFTLYWHVGNFVRSVNCPMCRTNVNLLVKSFSPNENLTNSDNKKRIVDEINCFNRLYSDAPRTWIEQIYDIPVILRHGFRHMLDGSSISIIHRLRITVLSIIVIGYCLSPLDIIPESGFGVLGILDDILILITFLMYILVFFRRAV 236

[Close]

BLAST of E3 ubiquitin-protein ligase RNF170 vs. Planmine SMEST
Match: SMESG000034017.1 (SMESG000034017.1)

HSP 1 Score: 97.8265 bits (242), Expect = 3.006e-23
Identity = 40/80 (50.00%), Postives = 64/80 (80.00%), Query Frame = 2

Query:   23 PNKPKGAWTAFFFFSDEHRKKIKEENPEYKVGDVAKVLGKMWEACKDKSKYEEQAKRDKERYNKELEEYKSGTPVSKKTK 262
            P +PK AW+AFF+F DE R K+++E+P+++V +VA+ LG++WEAC D+ +YE+ A  DKERY KE+E++++G  V+ +TK
Sbjct:   87 PGQPKRAWSAFFYFCDERRPKVRKEHPDWRVAEVARELGRLWEACSDRDRYEKMATLDKERYEKEMEQFRAGNFVAGETK 166

The following BLAST results are available for this feature:

BLAST of E3 ubiquitin-protein ligase RNF170 vs. Ensembl Human
BLAST of E3 ubiquitin-protein ligase RNF170 vs. Ensembl Celegans
BLAST of E3 ubiquitin-protein ligase RNF170 vs. Ensembl Fly
BLAST of E3 ubiquitin-protein ligase RNF170 vs. Ensembl Zebrafish
BLAST of E3 ubiquitin-protein ligase RNF170 vs. Ensembl Xenopus
BLAST of E3 ubiquitin-protein ligase RNF170 vs. Ensembl Mouse
BLAST of E3 ubiquitin-protein ligase RNF170 vs. UniProt/SwissProt
BLAST of E3 ubiquitin-protein ligase RNF170 vs. TrEMBL
BLAST of E3 ubiquitin-protein ligase RNF170 vs. Ensembl Cavefish
BLAST of E3 ubiquitin-protein ligase RNF170 vs. Ensembl Sea Lamprey
BLAST of E3 ubiquitin-protein ligase RNF170 vs. Ensembl Yeast
BLAST of E3 ubiquitin-protein ligase RNF170 vs. Ensembl Nematostella
BLAST of E3 ubiquitin-protein ligase RNF170 vs. Ensembl Medaka
BLAST of E3 ubiquitin-protein ligase RNF170 vs. Planmine SMEST

BLAST of E3 ubiquitin-protein ligase RNF170 vs. Ensembl Human
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Human e!99)
Total hits: 5


Match Name	E-value	Identity	Description
RNF170	1.529e-38	33.81	ring finger protein 170 [Source:HGNC Symbol;Acc:HG...	[more]
RNF170	1.529e-38	33.81	ring finger protein 170 [Source:HGNC Symbol;Acc:HG...	[more]
RNF170	4.046e-38	37.65	ring finger protein 170 [Source:HGNC Symbol;Acc:HG...	[more]
HMGB2	4.830e-13	44.05	high mobility group box 2 [Source:HGNC Symbol;Acc:...	[more]
HMGB2	4.830e-13	44.05	high mobility group box 2 [Source:HGNC Symbol;Acc:...	[more]

BLAST of E3 ubiquitin-protein ligase RNF170 vs. Ensembl Celegans
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99)
Total hits: 5


Match Name	E-value	Identity	Description
Y38F1A.2	1.981e-19	31.43	pep chromosome:WBcel235:II:12954962:12958018:1 gen...	[more]
hmg-1.2	9.581e-15	46.84	High mobility group protein 1.2 [Source:UniProtKB...	[more]
hmg-1.2	9.581e-15	46.84	High mobility group protein 1.2 [Source:UniProtKB...	[more]
hmg-1.2	9.699e-15	46.84	High mobility group protein 1.2 [Source:UniProtKB...	[more]
hmg-1.2	1.020e-14	46.84	High mobility group protein 1.2 [Source:UniProtKB...	[more]

BLAST of E3 ubiquitin-protein ligase RNF170 vs. Ensembl Fly
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99)
Total hits: 5


Match Name	E-value	Identity	Description
Dsp1	1.477e-16	46.43	gene:FBgn0278608 transcript:FBtr0089259	[more]
Dsp1	1.477e-16	46.43	gene:FBgn0278608 transcript:FBtr0089260	[more]
Dsp1	1.477e-16	46.43	gene:FBgn0278608 transcript:FBtr0089261	[more]
Dsp1	1.487e-16	46.43	gene:FBgn0278608 transcript:FBtr0089262	[more]
Dsp1	1.487e-16	46.43	gene:FBgn0278608 transcript:FBtr0339766	[more]

BLAST of E3 ubiquitin-protein ligase RNF170 vs. Ensembl Zebrafish
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99)
Total hits: 5


Match Name	E-value	Identity	Description
rnf170	3.402e-35	30.05	ring finger protein 170 [Source:NCBI gene;Acc:4066...	[more]
rnf170	3.402e-35	30.05	ring finger protein 170 [Source:NCBI gene;Acc:4066...	[more]
si:dkey-183n20.15	8.773e-19	27.36	si:dkey-183n20.15 [Source:ZFIN;Acc:ZDB-GENE-041001...	[more]
si:dkey-183n20.15	8.773e-19	27.36	si:dkey-183n20.15 [Source:ZFIN;Acc:ZDB-GENE-041001...	[more]
hmgb2b	5.497e-15	40.91	high mobility group box 2b [Source:ZFIN;Acc:ZDB-GE...	[more]

BLAST of E3 ubiquitin-protein ligase RNF170 vs. Ensembl Xenopus
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99)
Total hits: 5


Match Name	E-value	Identity	Description
pcmtd2	1.109e-38	32.86	protein-L-isoaspartate (D-aspartate) O-methyltrans...	[more]
ENSXETT00000034170.1	2.173e-28	29.81	uncharacterized loc100145035 [Source:NCBI gene;Acc...	[more]
ENSXETT00000034163.1	1.183e-27	29.47	uncharacterized loc100145035 [Source:NCBI gene;Acc...	[more]
hmgb2	4.597e-14	48.65	high mobility group box 2 [Source:NCBI gene;Acc:39...	[more]
cep170b	1.150e-13	47.50	centrosomal protein 170B [Source:Xenbase;Acc:XB-GE...	[more]

BLAST of E3 ubiquitin-protein ligase RNF170 vs. Ensembl Mouse
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99)
Total hits: 5


Match Name	E-value	Identity	Description
Rnf170	3.521e-38	34.40	ring finger protein 170 [Source:MGI Symbol;Acc:MGI...	[more]
Rnf170	2.149e-37	33.96	ring finger protein 170 [Source:MGI Symbol;Acc:MGI...	[more]
Rnf170	3.595e-26	34.53	ring finger protein 170 [Source:MGI Symbol;Acc:MGI...	[more]
Hmgb1	2.674e-12	48.75	high mobility group box 1 [Source:MGI Symbol;Acc:M...	[more]
Hmgb1	3.942e-12	48.75	high mobility group box 1 [Source:MGI Symbol;Acc:M...	[more]

BLAST of E3 ubiquitin-protein ligase RNF170 vs. UniProt/SwissProt
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt)
Total hits: 5


Match Name	E-value	Identity	Description
sp\|Q28DS3\|RN170_XENTR	5.874e-38	32.86	E3 ubiquitin-protein ligase RNF170 OS=Xenopus trop...	[more]
sp\|Q96K19\|RN170_HUMAN	7.342e-38	33.81	E3 ubiquitin-protein ligase RNF170 OS=Homo sapiens...	[more]
sp\|F1MK05\|RN170_BOVIN	1.272e-36	33.33	E3 ubiquitin-protein ligase RNF170 OS=Bos taurus O...	[more]
sp\|Q8CBG9\|RN170_MOUSE	1.503e-36	33.96	E3 ubiquitin-protein ligase RNF170 OS=Mus musculus...	[more]
sp\|Q7SZN2\|RN170_DANRE	2.905e-34	30.05	E3 ubiquitin-protein ligase RNF170 OS=Danio rerio ...	[more]

BLAST of E3 ubiquitin-protein ligase RNF170 vs. TrEMBL
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL)
Total hits: 5


Match Name	E-value	Identity	Description
I1ZIJ2	8.485e-58	100.00	High mobility group-1 OS=Schmidtea mediterranea OX...	[more]
A0A0R3UNK5	1.478e-37	39.33	RING-type domain-containing protein OS=Mesocestoid...	[more]
A0A2C9K1H4	6.745e-37	37.31	RING-type domain-containing protein OS=Biomphalari...	[more]
A0A4W3K3X3	7.498e-37	34.11	RING-type domain-containing protein OS=Callorhinch...	[more]
G3SSU1	1.991e-36	34.12	Ring finger protein 170 OS=Loxodonta africana OX=9...	[more]

BLAST of E3 ubiquitin-protein ligase RNF170 vs. Ensembl Cavefish
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99)
Total hits: 5


Match Name	E-value	Identity	Description
rnf170	5.621e-32	35.88	ring finger protein 170 [Source:NCBI gene;Acc:4066...	[more]
si:dkey-183n20.15	1.291e-20	29.26	E3 ubiquitin-protein ligase RNF170-like [Source:NC...	[more]
ENSAMXT00000044228.1	1.477e-15	43.18	high mobility group protein B2-like [Source:NCBI g...	[more]
hmgb2a	1.794e-14	45.95	high mobility group box 2 [Source:NCBI gene;Acc:11...	[more]
hmgb1a	5.617e-12	45.78	high mobility group-T protein-like [Source:NCBI ge...	[more]

BLAST of E3 ubiquitin-protein ligase RNF170 vs. Ensembl Sea Lamprey
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99)
Total hits: 3


Match Name	E-value	Identity	Description
hmgb2b	1.611e-13	42.22	high mobility group box 2b [Source:ZFIN;Acc:ZDB-GE...	[more]
hmgb2a	1.044e-11	45.57	high mobility group box 2a [Source:ZFIN;Acc:ZDB-GE...	[more]
ENSPMAT00000004052.1	8.242e-6	29.73	pep scaffold:Pmarinus_7.0:GL476375:218436:246333:-...	[more]

BLAST of E3 ubiquitin-protein ligase RNF170 vs. Ensembl Yeast
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46)
Total hits: 2


Match Name	E-value	Identity	Description
NHP6B	2.359e-14	41.03	High-mobility group (HMG) protein; binds to and re...	[more]
NHP6A	4.486e-13	43.24	High-mobility group (HMG) protein; binds to and re...	[more]

BLAST of E3 ubiquitin-protein ligase RNF170 vs. Ensembl Nematostella
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46)
Total hits: 5


Match Name	E-value	Identity	Description
EDO34494	1.317e-24	31.28	Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7...	[more]
EDO41032	1.990e-13	44.59	Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7...	[more]
EDO36028	1.392e-12	40.96	Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7...	[more]
EDO47230	1.284e-11	39.74	Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7...	[more]
EDO39305	1.439e-11	40.91	Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7...	[more]

BLAST of E3 ubiquitin-protein ligase RNF170 vs. Ensembl Medaka
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99)
Total hits: 5


Match Name	E-value	Identity	Description
rnf170	1.002e-35	31.33	E3 ubiquitin-protein ligase RNF170 [Source:NCBI ge...	[more]
hmgb2a	3.218e-15	47.30	high mobility group protein B2 [Source:NCBI gene;A...	[more]
si:dkey-183n20.15	3.887e-12	28.26	E3 ubiquitin-protein ligase RNF170 [Source:NCBI ge...	[more]
hmgb1a	2.735e-11	46.15	high mobility group-T protein [Source:NCBI gene;Ac...	[more]
hmgb1b	4.672e-10	43.04	high mobility group protein B1 [Source:NCBI gene;A...	[more]

BLAST of E3 ubiquitin-protein ligase RNF170 vs. Planmine SMEST
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST)
Total hits: 5


Match Name	E-value	Identity	Description
SMESG000068288.1	5.655e-159	99.54	SMESG000068288.1	[more]
SMESG000068286.1	2.360e-61	100.00	SMESG000068286.1	[more]
SMESG000020771.1	8.104e-33	66.67	SMESG000020771.1	[more]
SMESG000015032.1	2.760e-32	32.83	SMESG000015032.1	[more]
SMESG000034017.1	3.006e-23	50.00	SMESG000034017.1	[more]

Analyses

This transcript is derived from or has results from the following analyses


Analysis Name	Date Performed
Embryonic Stages	2016-07-25
Schmidtea mediterranea smed_20140614 BLASTX Human e!99	2016-08-08
Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99	2016-08-08
Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL	2020-05-01
Schmidtea mediterranea Sexual smed_20140614 transcriptome	2016-07-25
Schmidtea mediteranean smed_20140614 Interproscan	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST	2020-05-08

Sequences

The following sequences are available for this feature:

transcript sequence
protein sequence
protein sequence

transcript sequence

>SMED30012240 ID=SMED30012240|Name=E3 ubiquitin-protein ligase RNF170|organism=Schmidtea mediterranea sexual|type=transcript|length=1350bp
AAATAAAAGGAAAATTAAAGATCCAAATAAGCCAAAAGGTGCATGGACAG
CATTCTTCTTTTTTTCTGATGAACATCGCAAAAAAATTAAAGAAGAAAAT
CCAGAATATAAAGTTGGAGATGTTGCTAAAGTACTAGGTAAAATGTGGGA
AGCTTGTAAGGATAAAAGCAAATATGAAGAACAAGCAAAAAGAGATAAAG
AACGTTATAATAAAGAACTTGAAGAATACAAAAGTGGAACTCCGGTATCC
AAAAAAACAAAAGGTGCAGGTGATCAGGTCAATGGTAATCATGAAGATGA
TGATGAAGAAGATGATATCGAAGAAGATGACTAATTAACTGATTCCAGTG
TTTCATCAGATTTTATAGTGTGGTATAATCACGATTATCTGATGTTTTAT
TGTTAAGAAATGTTGCATTTATTTTATAGTGTTTTTGTATTGTAACTGTT
TATGTAATGTAAATATTTAAAAATTAAAGTAGTGTAATGTTAACATCACA
ATTATAAATAAATTTTAACGTAAGATTGTTTAAATCGTTTAGTGAAAGCG
CACATTTTTAAAATTTAAAATGTTTATTGAAGGTATTGAGAATGTTATTT
TATTAGTAATAATGTTAATGATCATATGTTTTCTATATATTTTACATTGT
TTAATATCGTTAATTAATAGATTTAATAGCAGTTACAATTTACATTCAAC
ATATGAAATACAGTACCAAGAATTTTTAAATCAGGCGAGAAATGAAAATA
TTCATAGTAATGCACCAAACAGGTGTCCTGTATGTTTAGAAGGCTGTAAA
TATTCTATTAAAACTAGCTGTAGTCATATGTTTTGTGGCCAGTGTTTGAT
TGGTTGGTCCAACACTGTAAATTTCCCTGGAGGTACCACATGTCCCGTTT
GTAGGACGTTGATAAAATTTTTGCTTCAATATTTTAATCAAGATGAAATA
ACGTCTGAGAGTACTGAAAAATCAGATGTATCAAACTTTGTCAAATATTA
TAATAGACGATATTCCGGAATGTCAGTTTCGGTGATTGATCAAATTCGTG
ATTTCCCAACTATTCTACGCAATGGAATTTGGAGAATAATTCAAGGAGAT
TTTAATTTCGCATTTCGAATGCGTATAATAATTGTCATCGCTGGAATGGT
GCTTTATGTACTATCACCTTTGGACATATTACCAGAATTTTTATTTGGAA
TTTTTGGTTTTGTTGACGATATAGCAGCTATTTTTTTAACTCTAAGCTAC
TTGAACTATTTATTTCGGCGATCTCTAACAACTTAAAATTTCCAAAAATG
TATCTGCCAAATGATTGAAATTTCGTTTGTAATATAAGTTTTGTATATTT

protein sequence of SMED30012240-orf-1

>SMED30012240-orf-1 ID=SMED30012240-orf-1|Name=SMED30012240-orf-1|organism=Schmidtea mediterranea sexual|type=polypeptide|length=111bp
NKRKIKDPNKPKGAWTAFFFFSDEHRKKIKEENPEYKVGDVAKVLGKMWE
ACKDKSKYEEQAKRDKERYNKELEEYKSGTPVSKKTKGAGDQVNGNHEDD
DEEDDIEEDD*

protein sequence of SMED30012240-orf-2

>SMED30012240-orf-2 ID=SMED30012240-orf-2|Name=SMED30012240-orf-2|organism=Schmidtea mediterranea sexual|type=polypeptide|length=239bp
MFIEGIENVILLVIMLMIICFLYILHCLISLINRFNSSYNLHSTYEIQYQ
EFLNQARNENIHSNAPNRCPVCLEGCKYSIKTSCSHMFCGQCLIGWSNTV
NFPGGTTCPVCRTLIKFLLQYFNQDEITSESTEKSDVSNFVKYYNRRYSG
MSVSVIDQIRDFPTILRNGIWRIIQGDFNFAFRMRIIIVIAGMVLYVLSP
LDILPEFLFGIFGFVDDIAAIFLTLSYLNYLFRRSLTT*

Annotated Terms

The following terms have been associated with this transcript:

Vocabulary: **molecular function**
Term	Definition
GO:0061630	ubiquitin protein ligase activity
GO:0008270	zinc ion binding
GO:0005515	protein binding
GO:0016740	transferase activity
GO:0046872	metal ion binding

Vocabulary: **Planarian Anatomy**
Term	Definition
PLANA:0000099	neuron
PLANA:0000429	neoblast
PLANA:0002109	X1 cell
PLANA:0002111	X2 cell

Vocabulary: **INTERPRO**
Term	Definition
IPR009071	HMG_box_dom
IPR001841	Znf_RING
IPR010652	DUF1232
IPR013083	Znf_RING/FYVE/PHD
IPR017907	Znf_RING_CS

Vocabulary: **cellular component**
Term	Definition
GO:0005783	endoplasmic reticulum
GO:0005789	endoplasmic reticulum membrane
GO:0016020	membrane
GO:0016021	integral component of membrane

Vocabulary: **biological process**
Term	Definition
GO:0016567	protein ubiquitination

InterPro

Analysis Name: Schmidtea mediteranean smed_20140614 Interproscan
Date Performed: 2020-05-01


IPR Term	IPR Description	Source	Source Term	Source Description	Alignment
IPR001841	Zinc finger, RING-type	SMART	SM00184	ring_2	coord: 69..111 e-value: 1.7E-4 score: 30.9
IPR001841	Zinc finger, RING-type	PROSITE	PS50089	ZF_RING_2	coord: 69..112 score: 11.973
IPR010652	Domain of unknown function DUF1232	PFAM	PF06803	DUF1232	coord: 187..223 e-value: 8.7E-9 score: 35.0
None	No IPR available	PFAM	PF13920	zf-C3HC4_3	coord: 67..116 e-value: 2.1E-6 score: 27.5
None	No IPR available	PANTHER	PTHR22894	UNCHARACTERIZED	coord: 13..236
None	No IPR available	PANTHER	PTHR22894:SF5	E3 UBIQUITIN-PROTEIN LIGASE RNF170-LIKE PROTEIN (DUF 1232)	coord: 13..236
None	No IPR available	SUPERFAMILY	SSF57850	RING/U-box	coord: 68..122
None	No IPR available	TMHMM	TMhelix		coord: 182..204
None	No IPR available	TMHMM	TMhelix		coord: 209..231
None	No IPR available	TMHMM	TMhelix		coord: 10..32
IPR013083	Zinc finger, RING/FYVE/PHD-type	GENE3D	G3DSA:3.30.40.10		coord: 46..147 e-value: 2.9E-13 score: 51.2
IPR017907	Zinc finger, RING-type, conserved site	PROSITE	PS00518	ZF_RING_1	coord: 84..93