SMED30012217

Overview
NameSMED30012217
Smed IDSMED30012217
Length (bp)1109
Neoblast Clusters

Zeng et. al., 2018



▻ Overview

▻ Neoblast Population

▻ Sub-lethal Irradiated Surviving X1 and X2 Cell Population

 

 

Overview

 

Single cell RNA-seq of pluripotent neoblasts and its early progenies


We isolated X1 neoblasts cells enriched in high piwi-1 expression (Neoblast Population), and profiled ∼7,614 individual cells via scRNA-seq. Unsupervised analyses uncovered 12 distinct classes from 7,088 high-quality cells. We designated these classes Nb1 to Nb12 and ordered them based on high (Nb1) to low (Nb12) piwi-1 expression levels. We further defined groups of genes that best classified the cells parsed into 12 distinct cell clusters to generate a scaled expression heat map of discriminative gene sets for each cluster. Expression of each cluster’s gene signatures was validated using multiplex fluorescence in situ hybridization (FISH) co-stained with piwi-1 and largely confirmed the cell clusters revealed by scRNA-seq.

We also tested sub-lethal irradiation exposure. To profile rare pluripotent stem cells (PSCs) and avoid interference from immediate progenitor cells, we determined a time point after sub-lethal irradiation (7 DPI) with minimal piwi-1+ cells, followed by isolation and single-cell RNA-seq of 1,200 individual cells derived from X1 (Piwi-1 high) and X2 (Piwi-1 low) cell populations (Sub-lethal Irradiated Surviving X1 and X2 Cell Population)



Explore this single cell expression dataset with our NB Cluster Shiny App



 

Neoblast Population

 

t-SNE plot shows two-dimensional representation of global gene expression relationships among all neoblasts (n = 7,088 after filter). Cluster identity was assigned based on the top 10 marker genes of each cluster (Table S2), followed by inspection of RNA in situ hybridization patterns. Neoblast groups, Nb.


Expression of SMED30012217 (SMED30012217) t-SNE clustered cells

Violin plots show distribution of expression levels for SMED30012217 (SMED30012217) in cells (dots) of each of the 12 neoblast clusters.

 

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Sub-lethal Irradiated Surviving X1 and X2 Cell Population

 

t-SNE plot of surviving X1 and X2 cells (n = 1,039 after QC filter) after sub-lethal irradiation. Colors indicate unbiased cell classification via graph-based clustering. SL, sub-lethal irradiated cell groups.

Expression of SMED30012217 (SMED30012217) in the t-SNE clustered sub-lethally irradiated X1 and X2 cells.

Violin plots show distribution of expression levels for SMED30012217 (SMED30012217) in cells (dots) of each of the 10 clusters of sub-leathally irradiated X1 and X2 cells.

 

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Embryonic Expression

Davies et. al., 2017

Hover the mouse over a column in the graph to view average RPKM values per sample.
Sort Descending | Sort Ascending | Only Non-Zero Values | Tile/Chart | Reset

Embryonic Stages: Y: yolk. S2-S8: Stages 2-8. C4: asexual adult. SX: virgin, sexually mature adult.
For further information about sample preparation and analysis for the single animal RNA-Seq experiment, please refer to the Materials and Methods

 

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Anatomical Expression

PAGE et. al., 2020



SMED30012217

has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGE



PAGE Curations: 18

  
Expressed InReference TranscriptGene ModelsPublished TranscriptTranscriptomePublicationSpecimenLifecycleEvidence
head regionSMED30012217h1SMcG0009335 SmedASXL_016242SmedAsxl_ww_GCZZ01PMID:27034770
Currie et al., 2016		whole organism asexual adult RNA-sequencing evidence
parapharyngeal regionSMED30012217h1SMcG0009335 SmedASXL_016243SmedAsxl_ww_GCZZ01PMID:27034770
Currie et al., 2016		whole organism asexual adult RNA-sequencing evidence
parapharyngeal regionSMED30012217h1SMcG0009333 SmedASXL_016243SmedAsxl_ww_GCZZ01PMID:27034770
Currie et al., 2016		whole organism asexual adult RNA-sequencing evidence
Smed sexual biotypeSMED30012217h1SMcG0009335 Contig43408uc_Smed_v2PMID:29674431
Fincher et al., 2018		FACS sorted cell population adult hermaphrodite single-cell RNA-sequencing evidence
Smed sexual biotypeSMED30012217h1SMcG0009335 Contig43408newmark_estsPMID:29674431
Fincher et al., 2018		FACS sorted cell population adult hermaphrodite single-cell RNA-sequencing evidence
pharynxSMED30012217h1SMcG0009335 dd_Smed_v4_6854_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018		FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
nervous systemSMED30012217h1SMcG0009335 dd_Smed_v4_6854_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018		FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
cephalic gangliaSMED30012217h1SMcG0009335 dd_Smed_v4_6854_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018		FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
muscle cellSMED30012217h1SMcG0009335 dd_Smed_v4_6854_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018		FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
neoblastSMED30012217h1SMcG0009335 dd_Smed_v4_6854_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018		FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
parenchymal cellSMED30012217h1SMcG0009335 dd_Smed_v4_6854_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018		FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
non-ciliated neuronSMED30012217h1SMcG0009335 dd_Smed_v4_6854_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018		FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
epidermisSMED30012217h1SMcG0009335 dd_Smed_v4_6854_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018		FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
neuronSMED30012217h1SMcG0009335 dd_Smed_v4_6854_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018		whole organism asexual adult colorimetric in situ hybridization evidence
cilated neuronSMED30012217h1SMcG0009335 dd_Smed_v4_6854_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018		FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
nervous systemSMED30012217 dd_Smed_v4_17391_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018		FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
cephalic gangliaSMED30012217 dd_Smed_v4_17391_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018		FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
head regionSMED30012217h1SMcG0009335 dd_Smed_v6_6854_0_1dd_Smed_v6PMID:28171748
Stückemann et al., 2017		whole organism asexual adult RNA-sequencing evidence
Note: Hover over icons to view figure legend
Alignments
SMED30012217 aligns in the following genomic locations:
Alignment LocationAlignment Score
v31.000173:75264..76510 +4660
v31.001409:25362..26504 -3754
Homology
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BLAST of SMED30012217 vs. Planmine SMEST
Match: SMESG000079382.1 (SMESG000079382.1)

HSP 1 Score: 526.554 bits (1355), Expect = 0.000e+0
Identity = 265/265 (100.00%), Postives = 265/265 (100.00%), Query Frame = 2 
Query:  173 MTKIYHCIKDKNMEDFRNKDPANGYAYHVTNIDCCGRTKLNMKKINWIRNRVDERVESIKSILSGESXXXXXXXXXXXDMTGLADQLAAINLNEDLELRPFEIRKSNYHPAVEGVEGVFMNTTLYDGHLPDWTVYPFGKPQCQVDHYYQRISIKFDKISEKYPQCKFWCIKDKQRHYICYKSESKIKNFNKTKSATAGIKFSEDFQDSELEVMGIKKEGATKDILPYLQNDYKKEEYFNNLVLLGGIEILGDAIIDIAHKFNCKS 967
            MTKIYHCIKDKNMEDFRNKDPANGYAYHVTNIDCCGRTKLNMKKINWIRNRVDERVESIKSILSGESQPNQPNQPNQQDMTGLADQLAAINLNEDLELRPFEIRKSNYHPAVEGVEGVFMNTTLYDGHLPDWTVYPFGKPQCQVDHYYQRISIKFDKISEKYPQCKFWCIKDKQRHYICYKSESKIKNFNKTKSATAGIKFSEDFQDSELEVMGIKKEGATKDILPYLQNDYKKEEYFNNLVLLGGIEILGDAIIDIAHKFNCKS
Sbjct:    1 MTKIYHCIKDKNMEDFRNKDPANGYAYHVTNIDCCGRTKLNMKKINWIRNRVDERVESIKSILSGESQPNQPNQPNQQDMTGLADQLAAINLNEDLELRPFEIRKSNYHPAVEGVEGVFMNTTLYDGHLPDWTVYPFGKPQCQVDHYYQRISIKFDKISEKYPQCKFWCIKDKQRHYICYKSESKIKNFNKTKSATAGIKFSEDFQDSELEVMGIKKEGATKDILPYLQNDYKKEEYFNNLVLLGGIEILGDAIIDIAHKFNCKS 265
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BLAST of SMED30012217 vs. Planmine SMEST
Match: SMESG000079382.1 (SMESG000079382.1)

HSP 1 Score: 501.901 bits (1291), Expect = 0.000e+0
Identity = 253/253 (100.00%), Postives = 253/253 (100.00%), Query Frame = 2 
Query:  209 MEDFRNKDPANGYAYHVTNIDCCGRTKLNMKKINWIRNRVDERVESIKSILSGESXXXXXXXXXXXDMTGLADQLAAINLNEDLELRPFEIRKSNYHPAVEGVEGVFMNTTLYDGHLPDWTVYPFGKPQCQVDHYYQRISIKFDKISEKYPQCKFWCIKDKQRHYICYKSESKIKNFNKTKSATAGIKFSEDFQDSELEVMGIKKEGATKDILPYLQNDYKKEEYFNNLVLLGGIEILGDAIIDIAHKFNCKS 967
            MEDFRNKDPANGYAYHVTNIDCCGRTKLNMKKINWIRNRVDERVESIKSILSGESQPNQPNQPNQQDMTGLADQLAAINLNEDLELRPFEIRKSNYHPAVEGVEGVFMNTTLYDGHLPDWTVYPFGKPQCQVDHYYQRISIKFDKISEKYPQCKFWCIKDKQRHYICYKSESKIKNFNKTKSATAGIKFSEDFQDSELEVMGIKKEGATKDILPYLQNDYKKEEYFNNLVLLGGIEILGDAIIDIAHKFNCKS
Sbjct:    1 MEDFRNKDPANGYAYHVTNIDCCGRTKLNMKKINWIRNRVDERVESIKSILSGESQPNQPNQPNQQDMTGLADQLAAINLNEDLELRPFEIRKSNYHPAVEGVEGVFMNTTLYDGHLPDWTVYPFGKPQCQVDHYYQRISIKFDKISEKYPQCKFWCIKDKQRHYICYKSESKIKNFNKTKSATAGIKFSEDFQDSELEVMGIKKEGATKDILPYLQNDYKKEEYFNNLVLLGGIEILGDAIIDIAHKFNCKS 253
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BLAST of SMED30012217 vs. Planmine SMEST
Match: SMESG000079668.1 (SMESG000079668.1)

HSP 1 Score: 395.201 bits (1014), Expect = 1.849e-138
Identity = 206/266 (77.44%), Postives = 218/266 (81.95%), Query Frame = 2 
Query:  224 NKDPANGYAYHVTNIDCCGRTKLNMKKINWIRNRVD------------------ERVESIKSILSGESXXXXXXXXXXXDMTGLADQLAAINLNEDLELRPFEIRKSNYHPAVEGVEGVFMNTTLYDGHLPDWTVYPFGKPQCQVDHYYQRISIKFDKISEKYPQCKFWCIKDKQRHYICYKSESKIKNFNKTKSATAGIKFSEDFQDSELEVMGIKKEGATKDILPYLQNDYKKEEYFNNLVLLGGIEILGDAIIDIAHKFNCKS 967
            N+DPANGYAYHVT+ DCCGRT  +M +INWIRNRVD                  E ++   SILSGESQPNQ  +  + D+T        IN     EL+ F IR+S YHP VEGVEGVFM+TTLYDGHLPDWTVYPFGKPQCQVDHYYQRISIKFDKISEKYPQCKFWCIKDKQRHYICYKSESKIKNFNKTKSATAGIKFSEDFQDSELEVMGIKKEGATKDILPYLQNDYKKEEYFNNLVLLGGIEILGDAIIDIAHKFNCKS
Sbjct:   12 NEDPANGYAYHVTSTDCCGRTDNDMLQINWIRNRVDGKKIFVFIKFFYILFGVKECLDHNSSILSGESQPNQQEEDEK-DLTYPFKMKTEINC----ELKAFRIRESYYHPTVEGVEGVFMSTTLYDGHLPDWTVYPFGKPQCQVDHYYQRISIKFDKISEKYPQCKFWCIKDKQRHYICYKSESKIKNFNKTKSATAGIKFSEDFQDSELEVMGIKKEGATKDILPYLQNDYKKEEYFNNLVLLGGIEILGDAIIDIAHKFNCKS 272
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BLAST of SMED30012217 vs. Planmine SMEST
Match: SMESG000079644.1 (SMESG000079644.1)

HSP 1 Score: 148.673 bits (374), Expect = 5.166e-42
Identity = 98/275 (35.64%), Postives = 146/275 (53.09%), Query Frame = 2 
Query:  218 FRNKDPANGYAYHVTNIDCCGRTKLNMKKINWIRNRVDERVESIKSILSGESXXXXXXXXXXXDMTGLADQLAAINLNEDLELRPFEIRKSNYHPAVEGVEGVFMNTTLYDGHLPDWT-VYPFGK---------PQCQVD----HYYQRISIKFDKISEKYPQCKFWCI-KD---------------KQRHYICYKS---------ESKIKNFNK--TKSATAGIKFSEDFQDSELEVMGIKKEGATKDILPYLQNDYKKEEYFNNLVLLGGIEI 919
            FR      GYAYHVT+IDCCG+T   M+ I+W  N   +        L  E       + + +D+     +   I  N+++ L+ FEI+K  YHP+ EGV+ VF+N TL++  LP+ T VYP  +         P  +++    H+YQRISIKF +IS++YP+CKFWC+ KD               KQ  YICY           E+K + ++    ++ +  I F +D    E   + I K+GATK+IL  +QN+Y K  Y+ ++VLLG I+I
Sbjct:    5 FRTTHSMRGYAYHVTSIDCCGKTDNTMRIIDWDHNPPRDGFH----YLDAEESQTSNEENSVEDLIDQMGKKVHIKDNKNI-LKAFEIKKCKYHPSAEGVKAVFLNLTLFNNSLPNSTKVYPHARQIFSEDYCIPSRRLEYPYGHFYQRISIKFKRISKRYPKCKFWCLMKDEDKGRSEKFTNSSCVKQISYICYNEEEEIENITFENKYEEYDVEIVRNRSDEILFYDDIDQYERCKLKIIKDGATKNILNLIQNNYYKNTYYTSIVLLGDIDI 274
[Close]
BLAST of SMED30012217 vs. Planmine SMEST
Match: SMESG000079644.1 (SMESG000079644.1)

HSP 1 Score: 144.821 bits (364), Expect = 9.736e-41
Identity = 96/267 (35.96%), Postives = 144/267 (53.93%), Query Frame = 2 
Query:  242 GYAYHVTNIDCCGRTKLNMKKINWIRNRVDERVESIKSILSGESXXXXXXXXXXXDMTGLADQLAAINLNEDLELRPFEIRKSNYHPAVEGVEGVFMNTTLYDGHLPDWT-VYPFGK---------PQCQVD----HYYQRISIKFDKISEKYPQCKFWCI-KD---------------KQRHYICYKS---------ESKIKNFNK--TKSATAGIKFSEDFQDSELEVMGIKKEGATKDILPYLQNDYKKEEYFNNLVLLGGIEI 919
            GYAYHVT+IDCCG+T   M+ I+W  N   +        L  E       + + +D+     +   I  N+++ L+ FEI+K  YHP+ EGV+ VF+N TL++  LP+ T VYP  +         P  +++    H+YQRISIKF +IS++YP+CKFWC+ KD               KQ  YICY           E+K + ++    ++ +  I F +D    E   + I K+GATK+IL  +QN+Y K  Y+ ++VLLG I+I
Sbjct:    3 GYAYHVTSIDCCGKTDNTMRIIDWDHNPPRDGFH----YLDAEESQTSNEENSVEDLIDQMGKKVHIKDNKNI-LKAFEIKKCKYHPSAEGVKAVFLNLTLFNNSLPNSTKVYPHARQIFSEDYCIPSRRLEYPYGHFYQRISIKFKRISKRYPKCKFWCLMKDEDKGRSEKFTNSSCVKQISYICYNEEEEIENITFENKYEEYDVEIVRNRSDEILFYDDIDQYERCKLKIIKDGATKNILNLIQNNYYKNTYYTSIVLLGDIDI 264
The following BLAST results are available for this feature:
BLAST of SMED30012217 vs. Ensembl Human
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Human e!99)
Total hits: 0
Match NameE-valueIdentityDescription
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BLAST of SMED30012217 vs. Ensembl Celegans
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99)
Total hits: 0
Match NameE-valueIdentityDescription
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BLAST of SMED30012217 vs. Ensembl Fly
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99)
Total hits: 0
Match NameE-valueIdentityDescription
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BLAST of SMED30012217 vs. Ensembl Zebrafish
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99)
Total hits: 0
Match NameE-valueIdentityDescription
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BLAST of SMED30012217 vs. Ensembl Xenopus
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99)
Total hits: 0
Match NameE-valueIdentityDescription
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BLAST of SMED30012217 vs. Ensembl Mouse
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99)
Total hits: 0
Match NameE-valueIdentityDescription
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BLAST of SMED30012217 vs. UniProt/SwissProt
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt)
Total hits: 0
Match NameE-valueIdentityDescription
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BLAST of SMED30012217 vs. TrEMBL
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL)
Total hits: 0
Match NameE-valueIdentityDescription
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BLAST of SMED30012217 vs. Ensembl Cavefish
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99)
Total hits: 0
Match NameE-valueIdentityDescription
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BLAST of SMED30012217 vs. Ensembl Sea Lamprey
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99)
Total hits: 0
Match NameE-valueIdentityDescription
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BLAST of SMED30012217 vs. Ensembl Yeast
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46)
Total hits: 0
Match NameE-valueIdentityDescription
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BLAST of SMED30012217 vs. Ensembl Nematostella
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46)
Total hits: 0
Match NameE-valueIdentityDescription
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BLAST of SMED30012217 vs. Ensembl Medaka
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99)
Total hits: 0
Match NameE-valueIdentityDescription
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BLAST of SMED30012217 vs. Planmine SMEST
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST)
Total hits: 5
Match NameE-valueIdentityDescription
SMESG000079382.10.000e+0100.00SMESG000079382.1[more]
SMESG000079382.10.000e+0100.00SMESG000079382.1[more]
SMESG000079668.11.849e-13877.44SMESG000079668.1[more]
SMESG000079644.15.166e-4235.64SMESG000079644.1[more]
SMESG000079644.19.736e-4135.96SMESG000079644.1[more]
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Sequences
The following sequences are available for this feature:

transcript sequence

>SMED30012217 ID=SMED30012217|Name=SMED30012217|organism=Schmidtea mediterranea sexual|type=transcript|length=1109bp
AGGGCGAAAACTAAATAAACTAAAAATCAAGTTTTGATGTAGATTTTGTA
ATATTTACATTGTTGATTTTAGATTTTAGGAAGAAAATTCAAAACTTGTG
GAAAACGAAACTTTGAATAAATCTTTTCGTATTCAAAATCAAGTCTATTT
TTAGAAAGTCGTAACCAACAAAATGACAAAAATTTATCACTGCATAAAAG
ATAAAAACATGGAAGATTTCCGGAATAAAGATCCCGCAAATGGTTATGCC
TACCACGTGACCAATATTGATTGCTGTGGCAGAACTAAGCTTAACATGAA
AAAGATAAATTGGATCCGAAATCGCGTAGACGAACGTGTTGAAAGCATCA
AAAGTATATTATCAGGAGAATCGCAACCAAATCAACCAAATCAACCTAAT
CAGCAAGACATGACGGGTTTGGCGGACCAATTGGCAGCAATTAATTTAAA
TGAAGATTTAGAACTAAGGCCTTTTGAAATCAGAAAAAGTAATTATCATC
CAGCTGTGGAGGGTGTTGAAGGTGTCTTTATGAACACAACCTTATACGAT
GGCCACCTACCGGACTGGACTGTATATCCTTTTGGGAAACCACAATGTCA
AGTTGATCATTATTATCAAAGAATTTCAATTAAATTTGATAAAATATCTG
AAAAATATCCCCAATGCAAGTTCTGGTGCATAAAAGACAAACAGCGTCAT
TATATTTGCTATAAGTCGGAAAGCAAAATCAAAAATTTCAATAAAACAAA
AAGTGCAACAGCTGGTATTAAATTCTCCGAAGACTTTCAAGATTCAGAAT
TGGAGGTTATGGGGATTAAAAAAGAAGGAGCAACTAAAGATATTTTGCCT
TATCTTCAAAATGACTACAAAAAAGAAGAATATTTTAACAATCTTGTTTT
GTTAGGTGGCATAGAGATACTGGGGGACGCGATAATAGATATTGCTCACA
AATTCAATTGTAAATCCTGATCTGAACCTGTGATTCTGCGGTTATATCAA
AATTTCAATAATAACATTTAATACAAATCCACAACAAAGTCTTTCAATAT
GCTTTTTATATTGGATGCTTTATATTTGGATTTTTCAATTATTTTTCACT
CTTTTATTA
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protein sequence of SMED30012217-orf-1

>SMED30012217-orf-1 ID=SMED30012217-orf-1|Name=SMED30012217-orf-1|organism=Schmidtea mediterranea sexual|type=polypeptide|length=266bp
MTKIYHCIKDKNMEDFRNKDPANGYAYHVTNIDCCGRTKLNMKKINWIRN
RVDERVESIKSILSGESQPNQPNQPNQQDMTGLADQLAAINLNEDLELRP
FEIRKSNYHPAVEGVEGVFMNTTLYDGHLPDWTVYPFGKPQCQVDHYYQR
ISIKFDKISEKYPQCKFWCIKDKQRHYICYKSESKIKNFNKTKSATAGIK
FSEDFQDSELEVMGIKKEGATKDILPYLQNDYKKEEYFNNLVLLGGIEIL
GDAIIDIAHKFNCKS*
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