Pyruvate kinase

Overview


Name	Pyruvate kinase
Smed ID	SMED30012118
Length (bp)	2064

Neoblast Clusters

▻ Sub-lethal Irradiated Surviving X1 and X2 Cell Population

Overview

Single cell RNA-seq of pluripotent neoblasts and its early progenies

We isolated X1 neoblasts cells enriched in high piwi-1 expression (Neoblast Population), and profiled ∼7,614 individual cells via scRNA-seq. Unsupervised analyses uncovered 12 distinct classes from 7,088 high-quality cells. We designated these classes Nb1 to Nb12 and ordered them based on high (Nb1) to low (Nb12) piwi-1 expression levels. We further defined groups of genes that best classified the cells parsed into 12 distinct cell clusters to generate a scaled expression heat map of discriminative gene sets for each cluster. Expression of each cluster’s gene signatures was validated using multiplex fluorescence in situ hybridization (FISH) co-stained with piwi-1 and largely confirmed the cell clusters revealed by scRNA-seq.

We also tested sub-lethal irradiation exposure. To profile rare pluripotent stem cells (PSCs) and avoid interference from immediate progenitor cells, we determined a time point after sub-lethal irradiation (7 DPI) with minimal piwi-1+ cells, followed by isolation and single-cell RNA-seq of 1,200 individual cells derived from X1 (Piwi-1 high) and X2 (Piwi-1 low) cell populations (Sub-lethal Irradiated Surviving X1 and X2 Cell Population)

Explore this single cell expression dataset with our NB Cluster Shiny App

Neoblast Population

t-SNE plot shows two-dimensional representation of global gene expression relationships among all neoblasts (n = 7,088 after filter). Cluster identity was assigned based on the top 10 marker genes of each cluster (Table S2), followed by inspection of RNA in situ hybridization patterns. Neoblast groups, Nb.

Expression of Pyruvate kinase (SMED30012118) t-SNE clustered cells

Violin plots show distribution of expression levels for Pyruvate kinase (SMED30012118) in cells (dots) of each of the 12 neoblast clusters.

Sub-lethal Irradiated Surviving X1 and X2 Cell Population

t-SNE plot of surviving X1 and X2 cells (n = 1,039 after QC filter) after sub-lethal irradiation. Colors indicate unbiased cell classification via graph-based clustering. SL, sub-lethal irradiated cell groups.

Expression of Pyruvate kinase (SMED30012118) in the t-SNE clustered sub-lethally irradiated X1 and X2 cells.

Violin plots show distribution of expression levels for Pyruvate kinase (SMED30012118) in cells (dots) of each of the 10 clusters of sub-leathally irradiated X1 and X2 cells.

Embryonic Expression

Davies et. al., 2017

Hover the mouse over a column in the graph to view average RPKM values per sample.
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Embryonic Stages: Y: yolk. S2-S8: Stages 2-8. C4: asexual adult. SX: virgin, sexually mature adult.
For further information about sample preparation and analysis for the single animal RNA-Seq experiment, please refer to the Materials and Methods

Anatomical Expression

PAGE et. al., 2020

SMED30012118

has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGE

PAGE Curations: 5

Expressed In	Reference Transcript	Gene Models	Published Transcript	Transcriptome	Publication
protonephridia	SMED30012118	SMESG000017671.1	dd_Smed_v4_6483_0_1	dd_Smed_v4	PMID:29674431 Fincher et al., 2018
epidermis	SMED30012118	SMESG000017671.1	dd_Smed_v4_6483_0_1	dd_Smed_v4	PMID:29674431 Fincher et al., 2018
cephalic ganglia	SMED30012118	SMESG000017671.1	dd_Smed_v4_6483_0_1	dd_Smed_v4	PMID:29674431 Fincher et al., 2018
epidermis	SMED30012118	SMESG000017671.1	dd_Smed_v4_6483_0_1	dd_Smed_v4	PMID:28292427 Wurtzel et al., 2017
Category 4 cell	SMED30012118	SMESG000017671.1	dd_Smed_v4_6483_0_1	dd_Smed_v4	PMID:28292427 Wurtzel et al., 2017

Note: Hover over icons to view figure legend

Homology

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BLAST of Pyruvate kinase vs. Ensembl Human
Match: PKM (pyruvate kinase M1/2 [Source:HGNC Symbol;Acc:HGNC:9021])

HSP 1 Score: 644.04 bits (1660), Expect = 0.000e+0
Identity = 315/525 (60.00%), Postives = 399/525 (76.00%), Query Frame = 1

Query:  187 QSNYFFQERRRVHKDYA-TNLELVADLNIDSDPGVIRNTGIICTLGPACASVAILHKMIAAGMNVARLNFSHGTHEDHARSIKLLREAIATLKP----YRFPIAIALDTKGPEIRTGLINNNETGEVRLKKGNNIKLVVSEEYYRKCDENFIWVDYKSILKLLKVGNRIFIDDGLISLIVEEKDSEFLLCRIENGGMLGSRKGVNLPGVNVDLPAVSEKDKEDLKFAVEQNVDIVFASFIRNAESVNIIRKILGEKGKHILIISKIENQEGMIQFDEILEASDGIMVARGDLGIEIPPEKVICAQKMMIGKCNVAGKSVICATHMLESMITKSRPTRAEISDVANAVIDGSDCVMLSGESAKGRYPVEAVKMMHTICREAEHLFFQSNFFESIKETVNLPTDHTHSTAIAAVEAAQRCNAAVIIVLTTSGTSAKLIAKYRPSCPILTLTRNPITARQAHLWRGLHPILFSDPRKEEWPKDMDLRINFSINYAYQRGFVKALDIIIIVTGSKAGSGSTNTLQVVKL 1746
            ++   F + +++H   A T LE +  L+IDS P   RNTGIICT+GPA  SV  L +MI +GMNVARLNFSHGTHE HA +IK +R A  +       YR P+A+ALDTKGPEIRTGLI  + T EV LKKG  +K+ +   Y  KCDEN +W+DYK+I K+++VG++I++DDGLISL V++K ++FL+  +ENGG LGS+KGVNLPG  VDLPAVSEKD +DLKF VEQ+VD+VFASFIR A  V+ +RK+LGEKGK+I IISKIEN EG+ +FDEILEASDGIMVARGDLGIEIP EKV  AQKMMIG+CN AGK VICAT MLESMI K RPTRAE SDVANAV+DG+DC+MLSGE+AKG YP+EAV+M H I REAE   +    FE ++    + +D T +TA+ AVEA+ +C +  IIVLT SG SA  +A+YRP  PI+ +TRNP TARQAHL+RG+ P+L  DP +E W +D+DLR+NF++N    RGF K  D++I++TG + GSG TNT++VV +
Sbjct:    7 EAGTAFIQTQQLHAAMADTFLEHMCRLDIDSPPITARNTGIICTIGPASRSVETLKEMIKSGMNVARLNFSHGTHEYHAETIKNVRTATESFASDPILYR-PVAVALDTKGPEIRTGLIKGSGTAEVELKKGATLKITLDNAYMEKCDENILWLDYKNICKVVEVGSKIYVDDGLISLQVKQKGADFLVTEVENGGSLGSKKGVNLPGAAVDLPAVSEKDIQDLKFGVEQDVDMVFASFIRKASDVHEVRKVLGEKGKNIKIISKIENHEGVRRFDEILEASDGIMVARGDLGIEIPAEKVFLAQKMMIGRCNRAGKPVICATQMLESMIKKPRPTRAEGSDVANAVLDGADCIMLSGETAKGDYPLEAVRMQHLIAREAEAAIYHLQLFEELRRLAPITSDPTEATAVGAVEASFKCCSGAIIVLTKSGRSAHQVARYRPRAPIIAVTRNPQTARQAHLYRGIFPVLCKDPVQEAWAEDVDLRVNFAMNVGKARGFFKKGDVVIVLTGWRPGSGFTNTMRVVPV 530

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BLAST of Pyruvate kinase vs. Ensembl Human
Match: PKM (pyruvate kinase M1/2 [Source:HGNC Symbol;Acc:HGNC:9021])

HSP 1 Score: 640.958 bits (1652), Expect = 0.000e+0
Identity = 315/523 (60.23%), Postives = 396/523 (75.72%), Query Frame = 1

Query:  187 QSNYFFQERRRVHKDYA-TNLELVADLNIDSDPGVIRNTGIICTLGPACASVAILHKMIAAGMNVARLNFSHGTHEDHARSIKLLREAIATLKP----YRFPIAIALDTKGPEIRTGLINNNETGEVRLKKGNNIKLVVSEEYYRKCDENFIWVDYKSILKLLKVGNRIFIDDGLISLIVEEKDSEFLLCRIENGGMLGSRKGVNLPGVNVDLPAVSEKDKEDLKFAVEQNVDIVFASFIRNAESVNIIRKILGEKGKHILIISKIENQEGMIQFDEILEASDGIMVARGDLGIEIPPEKVICAQKMMIGKCNVAGKSVICATHMLESMITKSRPTRAEISDVANAVIDGSDCVMLSGESAKGRYPVEAVKMMHTICREAEHLFFQSNFFESIKETVNLPTDHTHSTAIAAVEAAQRCNAAVIIVLTTSGTSAKLIAKYRPSCPILTLTRNPITARQAHLWRGLHPILFSDPRKEEWPKDMDLRINFSINYAYQRGFVKALDIIIIVTGSKAGSGSTNTLQVV 1740
            ++   F + +++H   A T LE +  L+IDS P   RNTGIICT+GPA  SV  L +MI +GMNVARLNFSHGTHE HA +IK +R A  +       YR P+A+ALDTKGPEIRTGLI  + T EV LKKG  +K+ +   Y  KCDEN +W+DYK+I K+++VG++I++DDGLISL V++K ++FL+  +ENGG LGS+KGVNLPG  VDLPAVSEKD +DLKF VEQ+VD+VFASFIR A  V+ +RK+LGEKGK+I IISKIEN EG+ +FDEILEASDGIMVARGDLGIEIP EKV  AQKMMIG+CN AGK VICAT MLESMI K RPTRAE SDVANAV+DG+DC+MLSGE+AKG YP+EAV+M H I REAE   F    FE +    +  TD   + A+ +VEA+ +C AA +IVLT SG SA  +A+YRP  PI+ +TRNP TARQAHL+RG+ P+L  DP +E W +D+DLR+NF++N    RGF K  D++I++TG + GSG TNT++VV
Sbjct:    7 EAGTAFIQTQQLHAAMADTFLEHMCRLDIDSPPITARNTGIICTIGPASRSVETLKEMIKSGMNVARLNFSHGTHEYHAETIKNVRTATESFASDPILYR-PVAVALDTKGPEIRTGLIKGSGTAEVELKKGATLKITLDNAYMEKCDENILWLDYKNICKVVEVGSKIYVDDGLISLQVKQKGADFLVTEVENGGSLGSKKGVNLPGAAVDLPAVSEKDIQDLKFGVEQDVDMVFASFIRKASDVHEVRKVLGEKGKNIKIISKIENHEGVRRFDEILEASDGIMVARGDLGIEIPAEKVFLAQKMMIGRCNRAGKPVICATQMLESMIKKPRPTRAEGSDVANAVLDGADCIMLSGETAKGDYPLEAVRMQHLIAREAEAAMFHRKLFEELVRASSHSTDLMEAMAMGSVEASYKCLAAALIVLTESGRSAHQVARYRPRAPIIAVTRNPQTARQAHLYRGIFPVLCKDPVQEAWAEDVDLRVNFAMNVGKARGFFKKGDVVIVLTGWRPGSGFTNTMRVV 528

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Query:  187 QSNYFFQERRRVHKDYA-TNLELVADLNIDSDPGVIRNTGIICTLGPACASVAILHKMIAAGMNVARLNFSHGTHEDHARSIKLLREAIATLKP----YRFPIAIALDTKGPEIRTGLINNNETGEVRLKKGNNIKLVVSEEYYRKCDENFIWVDYKSILKLLKVGNRIFIDDGLISLIVEEKDSEFLLCRIENGGMLGSRKGVNLPGVNVDLPAVSEKDKEDLKFAVEQNVDIVFASFIRNAESVNIIRKILGEKGKHILIISKIENQEGMIQFDEILEASDGIMVARGDLGIEIPPEKVICAQKMMIGKCNVAGKSVICATHMLESMITKSRPTRAEISDVANAVIDGSDCVMLSGESAKGRYPVEAVKMMHTICREAEHLFFQSNFFESIKETVNLPTDHTHSTAIAAVEAAQRCNAAVIIVLTTSGTSAKLIAKYRPSCPILTLTRNPITARQAHLWRGLHPILFSDPRKEEWPKDMDLRINFSINYAYQRGFVKALDIIIIVTGSKAGSGSTNTLQVV 1740
            ++   F + +++H   A T LE +  L+IDS P   RNTGIICT+GPA  SV  L +MI +GMNVARLNFSHGTHE HA +IK +R A  +       YR P+A+ALDTKGPEIRTGLI  + T EV LKKG  +K+ +   Y  KCDEN +W+DYK+I K+++VG++I++DDGLISL V++K ++FL+  +ENGG LGS+KGVNLPG  VDLPAVSEKD +DLKF VEQ+VD+VFASFIR A  V+ +RK+LGEKGK+I IISKIEN EG+ +FDEILEASDGIMVARGDLGIEIP EKV  AQKMMIG+CN AGK VICAT MLESMI K RPTRAE SDVANAV+DG+DC+MLSGE+AKG YP+EAV+M H I REAE   F    FE +    +  TD   + A+ +VEA+ +C AA +IVLT SG SA  +A+YRP  PI+ +TRNP TARQAHL+RG+ P+L  DP +E W +D+DLR+NF++N    RGF K  D++I++TG + GSG TNT++VV
Sbjct:    7 EAGTAFIQTQQLHAAMADTFLEHMCRLDIDSPPITARNTGIICTIGPASRSVETLKEMIKSGMNVARLNFSHGTHEYHAETIKNVRTATESFASDPILYR-PVAVALDTKGPEIRTGLIKGSGTAEVELKKGATLKITLDNAYMEKCDENILWLDYKNICKVVEVGSKIYVDDGLISLQVKQKGADFLVTEVENGGSLGSKKGVNLPGAAVDLPAVSEKDIQDLKFGVEQDVDMVFASFIRKASDVHEVRKVLGEKGKNIKIISKIENHEGVRRFDEILEASDGIMVARGDLGIEIPAEKVFLAQKMMIGRCNRAGKPVICATQMLESMIKKPRPTRAEGSDVANAVLDGADCIMLSGETAKGDYPLEAVRMQHLIAREAEAAMFHRKLFEELVRASSHSTDLMEAMAMGSVEASYKCLAAALIVLTESGRSAHQVARYRPRAPIIAVTRNPQTARQAHLYRGIFPVLCKDPVQEAWAEDVDLRVNFAMNVGKARGFFKKGDVVIVLTGWRPGSGFTNTMRVV 528

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Query:  187 QSNYFFQERRRVHKDYA-TNLELVADLNIDSDPGVIRNTGIICTLGPACASVAILHKMIAAGMNVARLNFSHGTHEDHARSIKLLREAIATLKP----YRFPIAIALDTKGPEIRTGLINNNETGEVRLKKGNNIKLVVSEEYYRKCDENFIWVDYKSILKLLKVGNRIFIDDGLISLIVEEKDSEFLLCRIENGGMLGSRKGVNLPGVNVDLPAVSEKDKEDLKFAVEQNVDIVFASFIRNAESVNIIRKILGEKGKHILIISKIENQEGMIQFDEILEASDGIMVARGDLGIEIPPEKVICAQKMMIGKCNVAGKSVICATHMLESMITKSRPTRAEISDVANAVIDGSDCVMLSGESAKGRYPVEAVKMMHTICREAEHLFFQSNFFESIKETVNLPTDHTHSTAIAAVEAAQRCNAAVIIVLTTSGTSAKLIAKYRPSCPILTLTRNPITARQAHLWRGLHPILFSDPRKEEWPKDMDLRINFSINYAYQRGFVKALDIIIIVTGSKAGSGSTNTLQVV 1740
            ++   F + +++H   A T LE +  L+IDS P   RNTGIICT+GPA  SV  L +MI +GMNVARLNFSHGTHE HA +IK +R A  +       YR P+A+ALDTKGPEIRTGLI  + T EV LKKG  +K+ +   Y  KCDEN +W+DYK+I K+++VG++I++DDGLISL V++K ++FL+  +ENGG LGS+KGVNLPG  VDLPAVSEKD +DLKF VEQ+VD+VFASFIR A  V+ +RK+LGEKGK+I IISKIEN EG+ +FDEILEASDGIMVARGDLGIEIP EKV  AQKMMIG+CN AGK VICAT MLESMI K RPTRAE SDVANAV+DG+DC+MLSGE+AKG YP+EAV+M H I REAE   F    FE +    +  TD   + A+ +VEA+ +C AA +IVLT SG SA  +A+YRP  PI+ +TRNP TARQAHL+RG+ P+L  DP +E W +D+DLR+NF++N    RGF K  D++I++TG + GSG TNT++VV
Sbjct:    7 EAGTAFIQTQQLHAAMADTFLEHMCRLDIDSPPITARNTGIICTIGPASRSVETLKEMIKSGMNVARLNFSHGTHEYHAETIKNVRTATESFASDPILYR-PVAVALDTKGPEIRTGLIKGSGTAEVELKKGATLKITLDNAYMEKCDENILWLDYKNICKVVEVGSKIYVDDGLISLQVKQKGADFLVTEVENGGSLGSKKGVNLPGAAVDLPAVSEKDIQDLKFGVEQDVDMVFASFIRKASDVHEVRKVLGEKGKNIKIISKIENHEGVRRFDEILEASDGIMVARGDLGIEIPAEKVFLAQKMMIGRCNRAGKPVICATQMLESMIKKPRPTRAEGSDVANAVLDGADCIMLSGETAKGDYPLEAVRMQHLIAREAEAAMFHRKLFEELVRASSHSTDLMEAMAMGSVEASYKCLAAALIVLTESGRSAHQVARYRPRAPIIAVTRNPQTARQAHLYRGIFPVLCKDPVQEAWAEDVDLRVNFAMNVGKARGFFKKGDVVIVLTGWRPGSGFTNTMRVV 528

[Close]

Query:  187 QSNYFFQERRRVHKDYA-TNLELVADLNIDSDPGVIRNTGIICTLGPACASVAILHKMIAAGMNVARLNFSHGTHEDHARSIKLLREAIATLKP----YRFPIAIALDTKGPEIRTGLINNNETGEVRLKKGNNIKLVVSEEYYRKCDENFIWVDYKSILKLLKVGNRIFIDDGLISLIVEEKDSEFLLCRIENGGMLGSRKGVNLPGVNVDLPAVSEKDKEDLKFAVEQNVDIVFASFIRNAESVNIIRKILGEKGKHILIISKIENQEGMIQFDEILEASDGIMVARGDLGIEIPPEKVICAQKMMIGKCNVAGKSVICATHMLESMITKSRPTRAEISDVANAVIDGSDCVMLSGESAKGRYPVEAVKMMHTICREAEHLFFQSNFFESIKETVNLPTDHTHSTAIAAVEAAQRCNAAVIIVLTTSGTSAKLIAKYRPSCPILTLTRNPITARQAHLWRGLHPILFSDPRKEEWPKDMDLRINFSINYAYQRGFVKALDIIIIVTGSKAGSGSTNTLQVV 1740
            ++   F + +++H   A T LE +  L+IDS P   RNTGIICT+GPA  SV  L +MI +GMNVARLNFSHGTHE HA +IK +R A  +       YR P+A+ALDTKGPEIRTGLI  + T EV LKKG  +K+ +   Y  KCDEN +W+DYK+I K+++VG++I++DDGLISL V++K ++FL+  +ENGG LGS+KGVNLPG  VDLPAVSEKD +DLKF VEQ+VD+VFASFIR A  V+ +RK+LGEKGK+I IISKIEN EG+ +FDEILEASDGIMVARGDLGIEIP EKV  AQKMMIG+CN AGK VICAT MLESMI K RPTRAE SDVANAV+DG+DC+MLSGE+AKG YP+EAV+M H I REAE   F    FE +    +  TD   + A+ +VEA+ +C AA +IVLT SG SA  +A+YRP  PI+ +TRNP TARQAHL+RG+ P+L  DP +E W +D+DLR+NF++N    RGF K  D++I++TG + GSG TNT++VV
Sbjct:    7 EAGTAFIQTQQLHAAMADTFLEHMCRLDIDSPPITARNTGIICTIGPASRSVETLKEMIKSGMNVARLNFSHGTHEYHAETIKNVRTATESFASDPILYR-PVAVALDTKGPEIRTGLIKGSGTAEVELKKGATLKITLDNAYMEKCDENILWLDYKNICKVVEVGSKIYVDDGLISLQVKQKGADFLVTEVENGGSLGSKKGVNLPGAAVDLPAVSEKDIQDLKFGVEQDVDMVFASFIRKASDVHEVRKVLGEKGKNIKIISKIENHEGVRRFDEILEASDGIMVARGDLGIEIPAEKVFLAQKMMIGRCNRAGKPVICATQMLESMIKKPRPTRAEGSDVANAVLDGADCIMLSGETAKGDYPLEAVRMQHLIAREAEAAMFHRKLFEELVRASSHSTDLMEAMAMGSVEASYKCLAAALIVLTESGRSAHQVARYRPRAPIIAVTRNPQTARQAHLYRGIFPVLCKDPVQEAWAEDVDLRVNFAMNVGKARGFFKKGDVVIVLTGWRPGSGFTNTMRVV 528

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BLAST of Pyruvate kinase vs. Ensembl Celegans
Match: pyk-2 (Pyruvate kinase [Source:UniProtKB/TrEMBL;Acc:Q23539])

HSP 1 Score: 581.637 bits (1498), Expect = 0.000e+0
Identity = 285/506 (56.32%), Postives = 367/506 (72.53%), Query Frame = 1

Query:  223 HKDYATNLELVADLNIDSDPGVIRNTGIICTLGPACASVAILHKMIAAGMNVARLNFSHGTHEDHARSIKLLREAIATLKPYRFPIAIALDTKGPEIRTGLINNNETGEVRLKKGNNIKLVVSEEYYRKCDENFIWVDYKSILKLLKVGNRIFIDDGLISLIVEEKDSEFLLCRIENGGMLGSRKGVNLPGVNVDLPAVSEKDKEDLKFAVEQNVDIVFASFIRNAESVNIIRKILGEKGKHILIISKIENQEGMIQFDEILEASDGIMVARGDLGIEIPPEKVICAQKMMIGKCNVAGKSVICATHMLESMITKSRPTRAEISDVANAVIDGSDCVMLSGESAKGRYPVEAVKMMHTICREAEHLFFQSNFFESIKETVNLPTDHTHSTAIAAVEAAQRCNAAVIIVLTTSGTSAKLIAKYRPSCPILTLTRNPITARQAHLWRGLHPILFSDPRKEEWPKDMDLRINFSINYAYQRGFVKALDIIIIVTGSKAGSGSTNTLQVV 1740
            H    TN+  +  L I   P   R TG+ICT+GPAC+ V  L KMI  GMN+ARLNFSHGTHE HA +IK +REA A   P  FP+AIALDTKGPEIRTG+  NN   EV+L+ G ++++            + I+ DY+++ K+++ G+RI+IDDGLISLIVE  +   ++C IENGG LG+RKGVNLPG  VDLPAV+ KD EDL F VEQ VDI+FASFIRNA+ ++ IR++LGEKGKHI II+KIE+++G+   DEI+EASDG+MVARGDLGIEIP EKV  AQKM+I KCN+AGK VICAT MLESMITK RPTRAE SDVANAV+DG DCVMLSGE+AKG YPVEA+ +MH IC+EAE  FF    FE +      PT  TH+TAIAAV A   C A  II++TT+G +A+L ++YRP  PI+T++R+   +RQ HL RG+ P+ +   R +EW  D++ R+ + +N    RGF+   D +I++TG K G+G TNT+++V
Sbjct:   11 HSSATTNISHLCGLRISERPQKTRKTGVICTIGPACSDVETLRKMINTGMNIARLNFSHGTHEAHAATIKTIREA-AENAP--FPVAIALDTKGPEIRTGMFANN-MKEVQLENGKSVRVSTDPSMEFAATSSHIYADYRNLPKVVQPGSRIYIDDGLISLIVESCEETAVICTIENGGALGTRKGVNLPGTIVDLPAVTSKDIEDLLFGVEQGVDIIFASFIRNADGIHKIRQVLGEKGKHIYIIAKIESEDGVTNCDEIIEASDGVMVARGDLGIEIPAEKVFLAQKMLIAKCNLAGKPVICATQMLESMITKPRPTRAECSDVANAVLDGVDCVMLSGETAKGDYPVEALAIMHNICKEAESAFFHMKHFEELILHTKKPTGMTHTTAIAAVSATITCRAVAIILITTTGKTARLCSRYRPPVPIITVSRDERISRQLHLHRGIFPVYYPKGRIDEWDVDVEERVQYGVNLGKTRGFIHLGDPLIVITGWKQGAGFTNTMRIV 512

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BLAST of Pyruvate kinase vs. Ensembl Celegans
Match: pyk-2 (Pyruvate kinase [Source:UniProtKB/TrEMBL;Acc:Q23539])

HSP 1 Score: 578.941 bits (1491), Expect = 0.000e+0
Identity = 284/501 (56.69%), Postives = 366/501 (73.05%), Query Frame = 1

Query:  238 TNLELVADLNIDSDPGVIRNTGIICTLGPACASVAILHKMIAAGMNVARLNFSHGTHEDHARSIKLLREAIATLKPYRFPIAIALDTKGPEIRTGLINNNETGEVRLKKGNNIKLVVSEEYYRKCDENFIWVDYKSILKLLKVGNRIFIDDGLISLIVEEKDSEFLLCRIENGGMLGSRKGVNLPGVNVDLPAVSEKDKEDLKFAVEQNVDIVFASFIRNAESVNIIRKILGEKGKHILIISKIENQEGMIQFDEILEASDGIMVARGDLGIEIPPEKVICAQKMMIGKCNVAGKSVICATHMLESMITKSRPTRAEISDVANAVIDGSDCVMLSGESAKGRYPVEAVKMMHTICREAEHLFFQSNFFESIKETVNLPTDHTHSTAIAAVEAAQRCNAAVIIVLTTSGTSAKLIAKYRPSCPILTLTRNPITARQAHLWRGLHPILFSDPRKEEWPKDMDLRINFSINYAYQRGFVKALDIIIIVTGSKAGSGSTNTLQVV 1740
            TN+  +  L I   P   R TG+ICT+GPAC+ V  L KMI  GMN+ARLNFSHGTHE HA +IK +REA A   P  FP+AIALDTKGPEIRTG+  NN   EV+L+ G ++++            + I+ DY+++ K+++ G+RI+IDDGLISLIVE  +   ++C IENGG LG+RKGVNLPG  VDLPAV+ KD EDL F VEQ VDI+FASFIRNA+ ++ IR++LGEKGKHI II+KIE+++G+   DEI+EASDG+MVARGDLGIEIP EKV  AQKM+I KCN+AGK VICAT MLESMITK RPTRAE SDVANAV+DG DCVMLSGE+AKG YPVEA+ +MH IC+EAE  FF    FE +      PT  TH+TAIAAV A   C A  II++TT+G +A+L ++YRP  PI+T++R+   +RQ HL RG+ P+ +   R +EW  D++ R+ + +N    RGF+   D +I++TG K G+G TNT+++V
Sbjct:   14 TNISHLCGLRISERPQKTRKTGVICTIGPACSDVETLRKMINTGMNIARLNFSHGTHEAHAATIKTIREA-AENAP--FPVAIALDTKGPEIRTGMFANN-MKEVQLENGKSVRVSTDPSMEFAATSSHIYADYRNLPKVVQPGSRIYIDDGLISLIVESCEETAVICTIENGGALGTRKGVNLPGTIVDLPAVTSKDIEDLLFGVEQGVDIIFASFIRNADGIHKIRQVLGEKGKHIYIIAKIESEDGVTNCDEIIEASDGVMVARGDLGIEIPAEKVFLAQKMLIAKCNLAGKPVICATQMLESMITKPRPTRAECSDVANAVLDGVDCVMLSGETAKGDYPVEALAIMHNICKEAESAFFHMKHFEELILHTKKPTGMTHTTAIAAVSATITCRAVAIILITTTGKTARLCSRYRPPVPIITVSRDERISRQLHLHRGIFPVYYPKGRIDEWDVDVEERVQYGVNLGKTRGFIHLGDPLIVITGWKQGAGFTNTMRIV 510

[Close]

BLAST of Pyruvate kinase vs. Ensembl Celegans
Match: pyk-1 (Pyruvate kinase [Source:UniProtKB/TrEMBL;Acc:Q7JL40])

HSP 1 Score: 560.836 bits (1444), Expect = 0.000e+0
Identity = 289/519 (55.68%), Postives = 379/519 (73.03%), Query Frame = 1

Query:  193 NYFFQERRRVHKDYATNLELVADLNIDSDPGVIRNTGIICTLGPACASVAILHKMIAAGMNVARLNFSHGTHEDHARSIKLLREAIATLKPYRFPIAIALDTKGPEIRTGLINNNETGEVRLKKGNNIKLVVSEEYYRKCDENFIWVDYKSILKLLKVGNRIFIDDGLISLIVEEKDSEFLLCRIENGGMLGSRKGVNLPGVNVDLPAVSEKDKEDLKFAVEQNVDIVFASFIRNAESVNIIRKILGEKGKHILIISKIENQEGMIQFDEILEASDGIMVARGDLGIEIPPEKVICAQKMMIGKCNVAGKSVICATHMLESMITKSRPTRAEISDVANAVIDGSDCVMLSGESAKGRYPVEAVKMMHTICREAEHLFFQSNFFESIKETVNLPTDHTHSTAIAAVEAAQRCNAAVIIVLTTSGTSAKLIAKYRPSCPILTLTRNPITARQAHLWRGLHPILFSDPRKEEWPKDMDLRINFSINYAYQRGFVKALDIIIIVTGSKAGSGSTNTLQVVKLE 1749
            +YF QE++       T++E +  L+I   P ++R TGIICT+GPACASV +L K+I  GMN+ARLNFSHG+HE HA +I  +REA  +    R  I IALDTKGPEIRTGL+    + E+ L +G +I+L     +        ++VDYK+I K+L VG+R++IDDGLISLIVEE  ++ ++C +ENGGMLGSRKGVNLPG  VDLPAVSEKD +DL+F VEQ VDI+FASFIRNAE +  IRK+LGEKGK I II+KIENQEG+   DEI+  SDG+MVARGDLGIEIP EKV  AQKM+I KCN AGK VICAT MLESM+ K RPTRAE SDVANAV+DG+DCVMLSGE+AKG YPV+A+K+MH IC+EAE   +    F+ + +    PTD +H+ AIAA  AA  C+A+ I+++TT+G SA   ++Y+P+ PILT++R+    RQ HL+RG+ P+ +   R  +WP D+D RIN +I     RGF+   D +++VTG + G+G+TNTL+++  E
Sbjct:   41 DYFKQEQKLAAVPATTHMEHLCRLDIREAPHLVRQTGIICTIGPACASVEMLQKLILNGMNIARLNFSHGSHEYHAGTIANVREAADSFSDKRV-IGIALDTKGPEIRTGLLAGGASAEIELARGASIRLTTDPHFSESGTAVNLFVDYKNIAKVLSVGSRVYIDDGLISLIVEELQTDAVICSVENGGMLGSRKGVNLPGTIVDLPAVSEKDCKDLQFGVEQGVDIIFASFIRNAEGIRTIRKVLGEKGKKIKIIAKIENQEGVDNADEIISESDGVMVARGDLGIEIPAEKVFLAQKMLISKCNRAGKPVICATQMLESMVHKPRPTRAEGSDVANAVLDGADCVMLSGETAKGEYPVDALKIMHYICKEAEAAVYHRRLFDELLQNTQKPTDMSHTIAIAATSAAASCHASAILLITTTGRSAIQCSRYKPAVPILTISRDVAVCRQLHLYRGVFPVHYPAERAADWPTDVDNRINHAIAIGKDRGFIHKGDFLVVVTGWRQGAGATNTLRIITAE 558

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Query:  193 NYFFQERRRVHKDYATNLELVADLNIDSDPGVIRNTGIICTLGPACASVAILHKMIAAGMNVARLNFSHGTHEDHARSIKLLREAIATLKPYRFPIAIALDTKGPEIRTGLINNNETGEVRLKKGNNIKLVVSEEYYRKCDENFIWVDYKSILKLLKVGNRIFIDDGLISLIVEEKDSEFLLCRIENGGMLGSRKGVNLPGVNVDLPAVSEKDKEDLKFAVEQNVDIVFASFIRNAESVNIIRKILGEKGKHILIISKIENQEGMIQFDEILEASDGIMVARGDLGIEIPPEKVICAQKMMIGKCNVAGKSVICATHMLESMITKSRPTRAEISDVANAVIDGSDCVMLSGESAKGRYPVEAVKMMHTICREAEHLFFQSNFFESIKETVNLPTDHTHSTAIAAVEAAQRCNAAVIIVLTTSGTSAKLIAKYRPSCPILTLTRNPITARQAHLWRGLHPILFSDPRKEEWPKDMDLRINFSINYAYQRGFVKALDIIIIVTGSKAGSGSTNTLQVVKLE 1749
            +YF QE++       T++E +  L+I   P ++R TGIICT+GPACASV +L K+I  GMN+ARLNFSHG+HE HA +I  +REA  +    R  I IALDTKGPEIRTGL+    + E+ L +G +I+L     +        ++VDYK+I K+L VG+R++IDDGLISLIVEE  ++ ++C +ENGGMLGSRKGVNLPG  VDLPAVSEKD +DL+F VEQ VDI+FASFIRNAE +  IRK+LGEKGK I II+KIENQEG+   DEI+  SDG+MVARGDLGIEIP EKV  AQKM+I KCN AGK VICAT MLESM+ K RPTRAE SDVANAV+DG+DCVMLSGE+AKG YPV+A+K+MH IC+EAE   +    F+ + +    PTD +H+ AIAA  AA  C+A+ I+++TT+G SA   ++Y+P+ PILT++R+    RQ HL+RG+ P+ +   R  +WP D+D RIN +I     RGF+   D +++VTG + G+G+TNTL+++  E
Sbjct:   45 DYFKQEQKLAAVPATTHMEHLCRLDIREAPHLVRQTGIICTIGPACASVEMLQKLILNGMNIARLNFSHGSHEYHAGTIANVREAADSFSDKRV-IGIALDTKGPEIRTGLLAGGASAEIELARGASIRLTTDPHFSESGTAVNLFVDYKNIAKVLSVGSRVYIDDGLISLIVEELQTDAVICSVENGGMLGSRKGVNLPGTIVDLPAVSEKDCKDLQFGVEQGVDIIFASFIRNAEGIRTIRKVLGEKGKKIKIIAKIENQEGVDNADEIISESDGVMVARGDLGIEIPAEKVFLAQKMLISKCNRAGKPVICATQMLESMVHKPRPTRAEGSDVANAVLDGADCVMLSGETAKGEYPVDALKIMHYICKEAEAAVYHRRLFDELLQNTQKPTDMSHTIAIAATSAAASCHASAILLITTTGRSAIQCSRYKPAVPILTISRDVAVCRQLHLYRGVFPVHYPAERAADWPTDVDNRINHAIAIGKDRGFIHKGDFLVVVTGWRQGAGATNTLRIITAE 562

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BLAST of Pyruvate kinase vs. Ensembl Celegans
Match: pyk-1 (Pyruvate kinase [Source:UniProtKB/TrEMBL;Acc:Q7JL40])

HSP 1 Score: 558.91 bits (1439), Expect = 0.000e+0
Identity = 290/525 (55.24%), Postives = 380/525 (72.38%), Query Frame = 1

Query:  175 RYFEQSNYFFQERRRVHKDYATNLELVADLNIDSDPGVIRNTGIICTLGPACASVAILHKMIAAGMNVARLNFSHGTHEDHARSIKLLREAIATLKPYRFPIAIALDTKGPEIRTGLINNNETGEVRLKKGNNIKLVVSEEYYRKCDENFIWVDYKSILKLLKVGNRIFIDDGLISLIVEEKDSEFLLCRIENGGMLGSRKGVNLPGVNVDLPAVSEKDKEDLKFAVEQNVDIVFASFIRNAESVNIIRKILGEKGKHILIISKIENQEGMIQFDEILEASDGIMVARGDLGIEIPPEKVICAQKMMIGKCNVAGKSVICATHMLESMITKSRPTRAEISDVANAVIDGSDCVMLSGESAKGRYPVEAVKMMHTICREAEHLFFQSNFFESIKETVNLPTDHTHSTAIAAVEAAQRCNAAVIIVLTTSGTSAKLIAKYRPSCPILTLTRNPITARQAHLWRGLHPILFSDPRKEEWPKDMDLRINFSINYAYQRGFVKALDIIIIVTGSKAGSGSTNTLQVVKLE 1749
            +  E S Y  QE++       T++E +  L+I   P ++R TGIICT+GPACASV +L K+I  GMN+ARLNFSHG+HE HA +I  +REA  +    R  I IALDTKGPEIRTGL+    + E+ L +G +I+L     +        ++VDYK+I K+L VG+R++IDDGLISLIVEE  ++ ++C +ENGGMLGSRKGVNLPG  VDLPAVSEKD +DL+F VEQ VDI+FASFIRNAE +  IRK+LGEKGK I II+KIENQEG+   DEI+  SDG+MVARGDLGIEIP EKV  AQKM+I KCN AGK VICAT MLESM+ K RPTRAE SDVANAV+DG+DCVMLSGE+AKG YPV+A+K+MH IC+EAE   +    F+ + +    PTD +H+ AIAA  AA  C+A+ I+++TT+G SA   ++Y+P+ PILT++R+    RQ HL+RG+ P+ +   R  +WP D+D RIN +I     RGF+   D +++VTG + G+G+TNTL+++  E
Sbjct:    8 KELEASGYDKQEQKLAAVPATTHMEHLCRLDIREAPHLVRQTGIICTIGPACASVEMLQKLILNGMNIARLNFSHGSHEYHAGTIANVREAADSFSDKRV-IGIALDTKGPEIRTGLLAGGASAEIELARGASIRLTTDPHFSESGTAVNLFVDYKNIAKVLSVGSRVYIDDGLISLIVEELQTDAVICSVENGGMLGSRKGVNLPGTIVDLPAVSEKDCKDLQFGVEQGVDIIFASFIRNAEGIRTIRKVLGEKGKKIKIIAKIENQEGVDNADEIISESDGVMVARGDLGIEIPAEKVFLAQKMLISKCNRAGKPVICATQMLESMVHKPRPTRAEGSDVANAVLDGADCVMLSGETAKGEYPVDALKIMHYICKEAEAAVYHRRLFDELLQNTQKPTDMSHTIAIAATSAAASCHASAILLITTTGRSAIQCSRYKPAVPILTISRDVAVCRQLHLYRGVFPVHYPAERAADWPTDVDNRINHAIAIGKDRGFIHKGDFLVVVTGWRQGAGATNTLRIITAE 531

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BLAST of Pyruvate kinase vs. Ensembl Fly
Match: PyK (gene:FBgn0267385 transcript:FBtr0084213)

HSP 1 Score: 580.482 bits (1495), Expect = 0.000e+0
Identity = 293/507 (57.79%), Postives = 372/507 (73.37%), Query Frame = 1

Query:  238 TNLELVADLNIDSDPGVIRNTGIICTLGPACASVAILHKMIAAGMNVARLNFSHGTHEDHARSIKLLREAIATLKP---YRFPIAIALDTKGPEIRTGLINNNETGEVRLKKGNNIKLVVSEEYYRKCDENFIWVDYKSILKLLKVGNRIFIDDGLISLIVEEKDSEFLLCRIENGGMLGSRKGVNLPGVNVDLPAVSEKDKEDLKFAVEQNVDIVFASFIRNAESVNIIRKILGEKGKHILIISKIENQEGMIQFDEILEASDGIMVARGDLGIEIPPEKVICAQKMMIGKCNVAGKSVICATHMLESMITKSRPTRAEISDVANAVIDGSDCVMLSGESAKGRYPVEAVKMMHTICREAEHLFFQSNFFESIKETVNLPTDHTHSTAIAAVEAAQRCNAAVIIVLTTSGTSAKLIAKYRPSCPILTLTRNPITARQAHLWRGLHPILFSDPRKEEWPKDMDLRINFSINYAYQRGFVKALDIIIIVTGSKAGSGSTNTLQVVKLE 1749
            T LE +  L  DS    +R +GI+CT+GPA +SV +L KM+A GMN+AR+NFSHG+HE HA ++  +R+A+        Y  P+AIALDTKGPEIRTGLI  + T E+ LKKG  IKL  ++E+  K     ++VDY++I+ ++K GNR+F+DDGLISLIV E   + L C +ENGG LGSRKGVNLPGV VDLPAVSEKDK DL F VEQ VD++FASFIRNA ++  IRK+LGEKGK+I IISKIENQ+GM   DEI+EA DGIMVARGDLGIEIP EKV  AQK MI +CN AGK VICAT MLESM+ K RPTRAEISDVANAV+DG+DCVMLSGE+AKG YP+E V  M   C+EAE   +  N F  +        D +H+ AIAAVEAA +  A+ I+V+TTSG SA  ++KYRP CPI+ +TR   TARQAHL+RGL P+++ +P   +W KD+D+R+ F +    + GF+K  D +++VTG K GSG TNT+++V +E
Sbjct:    7 TQLEHMCRLQFDSPVPHVRLSGIVCTIGPASSSVEMLEKMMATGMNIARMNFSHGSHEYHAATVANVRQAVKNYSAKLGYEHPVAIALDTKGPEIRTGLIGGSGTAEIELKKGEKIKLTTNKEFLEKGSLEIVYVDYENIVNVVKPGNRVFVDDGLISLIVREVGKDSLTCEVENGGSLGSRKGVNLPGVPVDLPAVSEKDKSDLLFGVEQEVDMIFASFIRNAAALTEIRKVLGEKGKNIKIISKIENQQGMHNLDEIIEAGDGIMVARGDLGIEIPAEKVFLAQKAMIARCNKAGKPVICATQMLESMVKKPRPTRAEISDVANAVLDGADCVMLSGETAKGEYPLECVLTMAKTCKEAEAALWHQNLFNDLVRGAGT-IDASHAAAIAAVEAATKAKASAIVVITTSGKSAFQVSKYRPRCPIIAVTRFAQTARQAHLYRGLVPLIYKEPGLGDWLKDVDVRVQFGLQVGKKNGFIKTGDSVVVVTGWKQGSGFTNTIRIVTVE 512

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BLAST of Pyruvate kinase vs. Ensembl Fly
Match: PyK (gene:FBgn0267385 transcript:FBtr0084214)

HSP 1 Score: 580.482 bits (1495), Expect = 0.000e+0
Identity = 293/507 (57.79%), Postives = 372/507 (73.37%), Query Frame = 1

Query:  238 TNLELVADLNIDSDPGVIRNTGIICTLGPACASVAILHKMIAAGMNVARLNFSHGTHEDHARSIKLLREAIATLKP---YRFPIAIALDTKGPEIRTGLINNNETGEVRLKKGNNIKLVVSEEYYRKCDENFIWVDYKSILKLLKVGNRIFIDDGLISLIVEEKDSEFLLCRIENGGMLGSRKGVNLPGVNVDLPAVSEKDKEDLKFAVEQNVDIVFASFIRNAESVNIIRKILGEKGKHILIISKIENQEGMIQFDEILEASDGIMVARGDLGIEIPPEKVICAQKMMIGKCNVAGKSVICATHMLESMITKSRPTRAEISDVANAVIDGSDCVMLSGESAKGRYPVEAVKMMHTICREAEHLFFQSNFFESIKETVNLPTDHTHSTAIAAVEAAQRCNAAVIIVLTTSGTSAKLIAKYRPSCPILTLTRNPITARQAHLWRGLHPILFSDPRKEEWPKDMDLRINFSINYAYQRGFVKALDIIIIVTGSKAGSGSTNTLQVVKLE 1749
            T LE +  L  DS    +R +GI+CT+GPA +SV +L KM+A GMN+AR+NFSHG+HE HA ++  +R+A+        Y  P+AIALDTKGPEIRTGLI  + T E+ LKKG  IKL  ++E+  K     ++VDY++I+ ++K GNR+F+DDGLISLIV E   + L C +ENGG LGSRKGVNLPGV VDLPAVSEKDK DL F VEQ VD++FASFIRNA ++  IRK+LGEKGK+I IISKIENQ+GM   DEI+EA DGIMVARGDLGIEIP EKV  AQK MI +CN AGK VICAT MLESM+ K RPTRAEISDVANAV+DG+DCVMLSGE+AKG YP+E V  M   C+EAE   +  N F  +        D +H+ AIAAVEAA +  A+ I+V+TTSG SA  ++KYRP CPI+ +TR   TARQAHL+RGL P+++ +P   +W KD+D+R+ F +    + GF+K  D +++VTG K GSG TNT+++V +E
Sbjct:   28 TQLEHMCRLQFDSPVPHVRLSGIVCTIGPASSSVEMLEKMMATGMNIARMNFSHGSHEYHAATVANVRQAVKNYSAKLGYEHPVAIALDTKGPEIRTGLIGGSGTAEIELKKGEKIKLTTNKEFLEKGSLEIVYVDYENIVNVVKPGNRVFVDDGLISLIVREVGKDSLTCEVENGGSLGSRKGVNLPGVPVDLPAVSEKDKSDLLFGVEQEVDMIFASFIRNAAALTEIRKVLGEKGKNIKIISKIENQQGMHNLDEIIEAGDGIMVARGDLGIEIPAEKVFLAQKAMIARCNKAGKPVICATQMLESMVKKPRPTRAEISDVANAVLDGADCVMLSGETAKGEYPLECVLTMAKTCKEAEAALWHQNLFNDLVRGAGT-IDASHAAAIAAVEAATKAKASAIVVITTSGKSAFQVSKYRPRCPIIAVTRFAQTARQAHLYRGLVPLIYKEPGLGDWLKDVDVRVQFGLQVGKKNGFIKTGDSVVVVTGWKQGSGFTNTIRIVTVE 533

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BLAST of Pyruvate kinase vs. Ensembl Fly
Match: CG2964 (gene:FBgn0031462 transcript:FBtr0077722)

HSP 1 Score: 431.024 bits (1107), Expect = 1.339e-143
Identity = 222/512 (43.36%), Postives = 337/512 (65.82%), Query Frame = 1

Query:  214 RRVHKDYATNLELVADLNIDSDPGVIRNTGIICTLGPACASVAILHKMIAAGMNVARLNFSHGTHEDHARSIKLLREAIATLKPYRFPI---AIALDTKGPEIRTGLINNNETGEVRLKKGNNIKLVVSEEYYRKCDENFIWVDYKSILKLLKVGNRIFIDDGLISLIVEEKDSEFLLCRIENGGMLGSRKGVNLPGVNVDLPAVSEKDKEDLKFAVEQNVDIVFASFIRNAESVNIIRKILGEKGKHILIISKIENQEGMIQFDEILEASDGIMVARGDLGIEIPPEKVICAQKMMIGKCNVAGKSVICATHMLESMITKSRPTRAEISDVANAVIDGSDCVMLSGESAKGRYPVEAVKMMHTICREAEHLFFQSNFFESIKETVNLPTDHTHSTAIAAVEAAQRCNAAVIIVLTTSGTSAKLIAKYRPSCPILTLTRNPITARQAHLWRGLHPILFSDPRKEEWPKDMDLRINFSINYAYQRGFVKALDIIIIVTGSKAGSGSTNTLQVV 1740
            + V K+ +T L  + +L++       R   +I T+  +  +   ++ MI  G+N+ RLNFSH +HE H+++I+L+ EA+  +      I   AIA DT+GP+IRTGL++    G+V L+ G+N++L ++ + Y K ++  ++VDY +I+ L K G+R+FIDDG + L + E   + LLC + +GG L +   V LP + +DLPAVSEKD  D++F+++ NVD +FAS +R+A++V  +R +LGEKGKHI II+K++++  + +F EIL A+DG++++R DLG +IP EK+   QK ++G+CN  GK VI A+H+LESM T   PTRAE  D+ANA+IDG+DC+MLS E A G +P E V    T+CREAE + +  + F  +   V    D  HS AIAAVE A+R NA +IIVLTTSG SA L++K+RP CPI+ +TR   TAR  +L RG+ PIL++     ++  D+D R+ F++  A + G +   D I+IV+  K G G TN ++VV
Sbjct:    6 KSVLKEGSTQLSHICELDLAQQASHQRLVSLIATISVSSRNADTIYTMIMRGVNIFRLNFSHESHEMHSKTIELINEALERIHKETGQIRTVAIAADTRGPQIRTGLLD----GDVFLRSGDNLRLSINRDLYDKGNKEAVYVDYPNIINLTKTGDRLFIDDGRLLLHILEVGVDGLLCEVIHGGQLNNNCNVILPEIEIDLPAVSEKDMFDIQFSIKANVDFLFASAVRSAKNVKELRTVLGEKGKHIKIIAKMDSKIALSRFSEILRAADGLLLSRADLGTQIPIEKLFITQKSILGQCNKVGKPVIVASHILESMRTLPHPTRAECFDLANAIIDGADCIMLSSEVAIGSFPKETVATCDTLCREAEKVLWFRDLFSDLVSEVRGELDAAHSLAIAAVETAKRTNATLIIVLTTSGRSATLVSKFRPRCPIMAITRCERTARWVYLHRGVLPILYTLEPSTDYATDVDARVQFAMTSAKKWGIIDDGDPIVIVSAWKDGGGFTNNVRVV 513

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BLAST of Pyruvate kinase vs. Ensembl Fly
Match: CG7069 (gene:FBgn0038952 transcript:FBtr0084215)

HSP 1 Score: 419.083 bits (1076), Expect = 1.409e-136
Identity = 209/410 (50.98%), Postives = 284/410 (69.27%), Query Frame = 1

Query:  370 MNVARLNFSHGTHEDHARSIKLLREAIAT-LKPYRFP--IAIALDTKGPEIRTG-LINNNETGEVRLKKGNNIKLVVSEEYYRKCDENFIWVDYKSILKLLKVGNRIFIDDGLISLIVEEKDSEFLLCRIENGGMLGSRKGVNLPGVNVDLPAVSEKDKEDLKFAVEQNVDIVFASFIRNAESVNIIRKILGEKGKHILIISKIENQEGMIQFDEILEASDGIMVARGDLGIEIPPEKVICAQKMMIGKCNVAGKSVICATHMLESMITKSRPTRAEISDVANAVIDGSDCVMLSGESAKGRYPVEAVKMMHTICREAEHLFFQSNFFESIKETVNLP-TDHTHSTAIAAVEAAQRCNAAVIIVLTTSGTSAKLIAKYRPSCPILTLTRNPITARQAHLWRGLHPILFSD 1584
            M V R+NFSHG+HE H ++I+  R+AIA  ++    P  +AIALDTKGPEIRTG L   N+  E+ LK G+ + L   +E   K +++ I+VDY+ + +L+K GNR+F+DDGLI+LIV+E   + ++C++ENGG LGS KG+NLPGV VDLP+V+EKDK+DLKF  EQ VD++FASFIR+A ++  IR++LG  G  I IISKIEN +G++  D+I+  SDGIMVARGD+GIEIP E V  AQK ++ KCN  GK VICAT M+ESM  K RPTRAE SDVANA+ DG D VMLSGE+AKG+YPVE V+ M  IC + E + +  +   S+K  +     DH  +   A  EAA    A  I+V +     A++++  RP CPI+ LT N   A Q+ L+RG++P+L  +
Sbjct:    1 MRVVRMNFSHGSHEYHCQTIQAARKAIAMYVEQTGLPRTLAIALDTKGPEIRTGKLAGGNDRAEIELKTGDKVTLSTKKEMADKSNKDNIYVDYQRLPQLVKPGNRVFVDDGLIALIVKESKGDEVICQVENGGKLGSHKGINLPGVPVDLPSVTEKDKQDLKFGAEQKVDMIFASFIRDANALKEIRQVLGPAGACIKIISKIENHQGLVNIDDIIRESDGIMVARGDMGIEIPTEDVPLAQKSIVAKCNKVGKPVICATQMMESMTNKPRPTRAEASDVANAIFDGCDAVMLSGETAKGKYPVECVQCMARICAKVEAVLWYESLQNSLKREIRTSAADHISAVTTAIAEAATVGQARAIVVASPCSMVAQMVSHMRPPCPIVMLTGNESEAAQSLLFRGIYPLLVEE 410

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BLAST of Pyruvate kinase vs. Ensembl Fly
Match: CG7362 (gene:FBgn0038258 transcript:FBtr0331700)

HSP 1 Score: 243.817 bits (621), Expect = 6.836e-70
Identity = 125/271 (46.13%), Postives = 179/271 (66.05%), Query Frame = 1

Query:  781 VNLPGVNVDLPAVSEKDKEDLKFAVEQNVDIVFASFIRNAESVNIIRKILG--EKGKHILIISKIENQEGMIQFDEILEASDGIMVARGDLGIEIPPEKVICAQKMMIGKCNVAGKSVICATHMLESMITKSRPTRAEISDVANAVIDGSDCVMLSGESAKGRYPVEAVKMMHTICREAEHLFFQSNFFESIKETVNL-PTDHTHSTAIAAVEAAQRCNAAVIIVLTTSGTSAKLIAKYRPSCPILTLTRNPITARQAHLWRGLHPILFSD 1584
            +N  GV  DL A++E+DK DLKF  +Q VD++FASFIR+A+++  IR+ LG     +HI IISKIE+Q+ +   DEI+  SDGIMVA G++G EI  E V  AQK ++ KCN  GK VICA  M+ SMITK RPTRAE SDVANA++DG D ++LS E+AKG+YPV+ V+ M  IC + E + +  +   ++K  V +   DH  + + A  EAA    A  I+V +     ++++++ RP CPI+ LT  P  A Q+ L+RG++P+L  +
Sbjct:  109 INPQGVAADLNAITEQDKLDLKFGADQKVDMIFASFIRDAKALKEIRQALGACPSSEHIKIISKIESQQALANIDEIIRESDGIMVALGNMGNEIALEAVPLAQKSIVAKCNKVGKPVICANQMMNSMITKPRPTRAESSDVANAILDGCDALVLSDETAKGKYPVQCVQCMARICAKVESVLWYESIQNNLKSEVRINAADHISAVSTAIAEAATVSQAQAIVVASPCSIVSQMVSQMRPPCPIVLLTGCPHEAAQSLLFRGVYPLLVKE 379

HSP 2 Score: 70.0922 bits (170), Expect = 4.880e-12
Identity = 40/97 (41.24%), Postives = 58/97 (59.79%), Query Frame = 1

Query:  232 YATNLELVADLNIDSDPGVIRNTGIICTLGPACASVAILHKMIAAGMNVARLNFSHGTHEDHARSIKLLREAIATL-KPYRFP--IAIALDTKGPEI 513
            Y + L+  + L   +    +  T IICT+GP+ +   +L  +I AGM V RL+FS GTH+ H ++I+  R+AIA   +    P  +AIALDTKGP I
Sbjct:   13 YLSQLDYQSRLQFQAPALRLPLTSIICTIGPSSSQPEVLLNLIHAGMKVVRLDFSDGTHDCHCQAIQAARKAIAMYAEETGLPRSLAIALDTKGPVI 109

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BLAST of Pyruvate kinase vs. Ensembl Zebrafish
Match: pkma (pyruvate kinase M1/2a [Source:ZFIN;Acc:ZDB-GENE-031201-4])

HSP 1 Score: 629.787 bits (1623), Expect = 0.000e+0
Identity = 305/532 (57.33%), Postives = 398/532 (74.81%), Query Frame = 1

Query:  163 MQGARYFEQSNYFFQERRRVHKDYATNLELVADLNIDSDPGVIRNTGIICTLGPACASVAILHKMIAAGMNVARLNFSHGTHEDHARSIKLLREAIATLKP----YRFPIAIALDTKGPEIRTGLINNNETGEVRLKKGNNIKLVVSEEYYRKCDENFIWVDYKSILKLLKVGNRIFIDDGLISLIVEEKDSEFLLCRIENGGMLGSRKGVNLPGVNVDLPAVSEKDKEDLKFAVEQNVDIVFASFIRNAESVNIIRKILGEKGKHILIISKIENQEGMIQFDEILEASDGIMVARGDLGIEIPPEKVICAQKMMIGKCNVAGKSVICATHMLESMITKSRPTRAEISDVANAVIDGSDCVMLSGESAKGRYPVEAVKMMHTICREAEHLFFQSNFFESIKETVNLPTDHTHSTAIAAVEAAQRCNAAVIIVLTTSGTSAKLIAKYRPSCPILTLTRNPITARQAHLWRGLHPILFSDPRKEEWPKDMDLRINFSINYAYQRGFVKALDIIIIVTGSKAGSGSTNTLQVVKL 1746
            M   +  +  + F Q ++       T LE +  L+IDS+P + RNTGIICT+GPA  SV  L +MI +GMN+AR+NFSHG+HE H  +IK +REA A+ +P    YR P+ IALDTKGPEIRTGLI  + T EV LKKGN IK+ + + +   CDE+ +W+DYK+I K+++VG++++IDDGLISL V +  S++L+C IENGG LGS+KGVNLPG  VDLPAVSEKD +DL+F VE  VD++FASFIR A  V  +RK+LGEKGK+I IISK+EN EG+ +FDEI+EASDGIMVARGDLGIEIP EKV  AQKMMIG+CN AGK +ICAT MLESMI K RPTRAE SDVANAV+DG+DC+MLSGE+AKG YP+EAV+  H I REAE   F    FE ++ +  L  D + + A+ AVEA+ +C A+ II+LT +G SA LI++YRP  PIL +TRN  TARQAHL+RG+ PI ++ P  + W +D+DLR+NF+++    RGF KA D++I++TG + GSG TNT++VV +
Sbjct:    1 MSQTKAQDMGSAFIQTQQLNAAMADTFLEHMCLLDIDSEPTIARNTGIICTIGPASRSVDTLKEMIKSGMNIARMNFSHGSHEYHGETIKNVREACASFEPGSIQYR-PVGIALDTKGPEIRTGLIKGSGTAEVELKKGNKIKVTLDDSFMENCDEDTLWLDYKNITKVVEVGSKVYIDDGLISLQVLQIGSDYLICEIENGGSLGSKKGVNLPGAAVDLPAVSEKDIKDLQFGVEMGVDMIFASFIRKAADVQAVRKVLGEKGKNIKIISKLENHEGVRRFDEIMEASDGIMVARGDLGIEIPTEKVFLAQKMMIGRCNKAGKPIICATQMLESMIKKPRPTRAEGSDVANAVLDGADCIMLSGETAKGDYPLEAVRTQHMIAREAEAATFHRQLFEGLRRSSVLTRDPSDAVAVGAVEASFKCCASGIIILTKTGRSAHLISRYRPRAPILAVTRNEQTARQAHLYRGIFPIYYNSPSNDVWAEDVDLRVNFAMDVGKARGFFKAGDVVIVLTGWRPGSGYTNTMRVVPV 531

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Query:  163 MQGARYFEQSNYFFQERRRVHKDYATNLELVADLNIDSDPGVIRNTGIICTLGPACASVAILHKMIAAGMNVARLNFSHGTHEDHARSIKLLREAIATLKP----YRFPIAIALDTKGPEIRTGLINNNETGEVRLKKGNNIKLVVSEEYYRKCDENFIWVDYKSILKLLKVGNRIFIDDGLISLIVEEKDSEFLLCRIENGGMLGSRKGVNLPGVNVDLPAVSEKDKEDLKFAVEQNVDIVFASFIRNAESVNIIRKILGEKGKHILIISKIENQEGMIQFDEILEASDGIMVARGDLGIEIPPEKVICAQKMMIGKCNVAGKSVICATHMLESMITKSRPTRAEISDVANAVIDGSDCVMLSGESAKGRYPVEAVKMMHTICREAEHLFFQSNFFESIKETVNLPTDHTHSTAIAAVEAAQRCNAAVIIVLTTSGTSAKLIAKYRPSCPILTLTRNPITARQAHLWRGLHPILFSDPRKEEWPKDMDLRINFSINYAYQRGFVKALDIIIIVTGSKAGSGSTNTLQVVKL 1746
            M   +  +  + F Q ++       T LE +  L+IDS+P + RNTGIICT+GPA  SV  L +MI +GMN+AR+NFSHG+HE H  +IK +REA A+ +P    YR P+ IALDTKGPEIRTGLI  + T EV LKKGN IK+ + + +   CDE+ +W+DYK+I K+++VG++++IDDGLISL V +  S++L+C IENGG LGS+KGVNLPG  VDLPAVSEKD +DL+F VE  VD++FASFIR A  V  +RK+LGEKGK+I IISK+EN EG+ +FDEI+EASDGIMVARGDLGIEIP EKV  AQKMMIG+CN AGK +ICAT MLESMI K RPTRAE SDVANAV+DG+DC+MLSGE+AKG YP+EAV+  H I REAE   F    FE ++ +  L  D + + A+ AVEA+ +C A+ II+LT +G SA LI++YRP  PIL +TRN  TARQAHL+RG+ PI ++ P  + W +D+DLR+NF+++    RGF KA D++I++TG + GSG TNT++VV +
Sbjct:    1 MSQTKAQDMGSAFIQTQQLNAAMADTFLEHMCLLDIDSEPTIARNTGIICTIGPASRSVDTLKEMIKSGMNIARMNFSHGSHEYHGETIKNVREACASFEPGSIQYR-PVGIALDTKGPEIRTGLIKGSGTAEVELKKGNKIKVTLDDSFMENCDEDTLWLDYKNITKVVEVGSKVYIDDGLISLQVLQIGSDYLICEIENGGSLGSKKGVNLPGAAVDLPAVSEKDIKDLQFGVEMGVDMIFASFIRKAADVQAVRKVLGEKGKNIKIISKLENHEGVRRFDEIMEASDGIMVARGDLGIEIPTEKVFLAQKMMIGRCNKAGKPIICATQMLESMIKKPRPTRAEGSDVANAVLDGADCIMLSGETAKGDYPLEAVRTQHMIAREAEAATFHRQLFEGLRRSSVLTRDPSDAVAVGAVEASFKCCASGIIILTKTGRSAHLISRYRPRAPILAVTRNEQTARQAHLYRGIFPIYYNSPSNDVWAEDVDLRVNFAMDVGKARGFFKAGDVVIVLTGWRPGSGYTNTMRVVPV 531

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BLAST of Pyruvate kinase vs. Ensembl Zebrafish
Match: pkma (pyruvate kinase M1/2a [Source:ZFIN;Acc:ZDB-GENE-031201-4])

HSP 1 Score: 627.861 bits (1618), Expect = 0.000e+0
Identity = 306/532 (57.52%), Postives = 396/532 (74.44%), Query Frame = 1

Query:  163 MQGARYFEQSNYFFQERRRVHKDYATNLELVADLNIDSDPGVIRNTGIICTLGPACASVAILHKMIAAGMNVARLNFSHGTHEDHARSIKLLREAIATLKP----YRFPIAIALDTKGPEIRTGLINNNETGEVRLKKGNNIKLVVSEEYYRKCDENFIWVDYKSILKLLKVGNRIFIDDGLISLIVEEKDSEFLLCRIENGGMLGSRKGVNLPGVNVDLPAVSEKDKEDLKFAVEQNVDIVFASFIRNAESVNIIRKILGEKGKHILIISKIENQEGMIQFDEILEASDGIMVARGDLGIEIPPEKVICAQKMMIGKCNVAGKSVICATHMLESMITKSRPTRAEISDVANAVIDGSDCVMLSGESAKGRYPVEAVKMMHTICREAEHLFFQSNFFESIKETVNLPTDHTHSTAIAAVEAAQRCNAAVIIVLTTSGTSAKLIAKYRPSCPILTLTRNPITARQAHLWRGLHPILFSDPRKEEWPKDMDLRINFSINYAYQRGFVKALDIIIIVTGSKAGSGSTNTLQVVKL 1746
            M   +  +  + F Q ++       T LE +  L+IDS+P + RNTGIICT+GPA  SV  L +MI +GMN+AR+NFSHG+HE H  +IK +REA A+ +P    YR P+ IALDTKGPEIRTGLI  + T EV LKKGN IK+ + + +   CDE+ +W+DYK+I K+++VG++++IDDGLISL V +  S++L+C IENGG LGS+KGVNLPG  VDLPAVSEKD +DL+F VE  VD++FASFIR A  V  +RK+LGEKGK+I IISK+EN EG+ +FDEI+EASDGIMVARGDLGIEIP EKV  AQKMMIG+CN AGK +ICAT MLESMI K RPTRAE SDVANAV+DG+DC+MLSGE+AKG YP+EAV+  H I REAE   F    FE ++  + L TD   + AI AVEA+ +  ++  IVLT SG SA LI++YRP  PIL +TRN  TARQAHL+RG+ PI ++ P  + W +D+DLR+NF+++    RGF KA D++I++TG + GSG TNT++VV +
Sbjct:    1 MSQTKAQDMGSAFIQTQQLNAAMADTFLEHMCLLDIDSEPTIARNTGIICTIGPASRSVDTLKEMIKSGMNIARMNFSHGSHEYHGETIKNVREACASFEPGSIQYR-PVGIALDTKGPEIRTGLIKGSGTAEVELKKGNKIKVTLDDSFMENCDEDTLWLDYKNITKVVEVGSKVYIDDGLISLQVLQIGSDYLICEIENGGSLGSKKGVNLPGAAVDLPAVSEKDIKDLQFGVEMGVDMIFASFIRKAADVQAVRKVLGEKGKNIKIISKLENHEGVRRFDEIMEASDGIMVARGDLGIEIPTEKVFLAQKMMIGRCNKAGKPIICATQMLESMIKKPRPTRAEGSDVANAVLDGADCIMLSGETAKGDYPLEAVRTQHMIAREAEAAMFHRQVFEDLRRCLPLSTDPAEAIAIGAVEASFKILSSAFIVLTGSGRSAHLISRYRPRAPILAVTRNEQTARQAHLYRGIFPIYYNSPSNDVWAEDVDLRVNFAMDVGKARGFFKAGDVVIVLTGWRPGSGYTNTMRVVPV 531

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BLAST of Pyruvate kinase vs. Ensembl Zebrafish
Match: pkmb (pyruvate kinase M1/2b [Source:ZFIN;Acc:ZDB-GENE-040801-230])

HSP 1 Score: 627.476 bits (1617), Expect = 0.000e+0
Identity = 309/518 (59.65%), Postives = 391/518 (75.48%), Query Frame = 1

Query:  199 FFQERRRVHKDYATNLELVADLNIDSDPGVIRNTGIICTLGPACASVAILHKMIAAGMNVARLNFSHGTHEDHARSIKLLREAIATLKP----YRFPIAIALDTKGPEIRTGLINNNETGEVRLKKGNNIKLVVSEEYYRKCDENFIWVDYKSILKLLKVGNRIFIDDGLISLIVEEKDSEFLLCRIENGGMLGSRKGVNLPGVNVDLPAVSEKDKEDLKFAVEQNVDIVFASFIRNAESVNIIRKILGEKGKHILIISKIENQEGMIQFDEILEASDGIMVARGDLGIEIPPEKVICAQKMMIGKCNVAGKSVICATHMLESMITKSRPTRAEISDVANAVIDGSDCVMLSGESAKGRYPVEAVKMMHTICREAEHLFFQSNFFESIKETVNLPTDHTHSTAIAAVEAAQRCNAAVIIVLTTSGTSAKLIAKYRPSCPILTLTRNPITARQAHLWRGLHPILFSDPRKEEWPKDMDLRINFSINYAYQRGFVKALDIIIIVTGSKAGSGSTNTLQVV 1740
            F Q ++       T LE +  L+IDS+P V RNTGI+CTLGPA  S+  L +MI +GMNVARLNFSHGTHE HA +IK +REAI +       YR P+AIALDTKGPEIRTGLI  + T EV+L KGN IKL + +++   CDEN +W+DYK+I K+++ G+ I++DDGLISL V+E  S+FL C IENGGMLGS+KGVNLPG NVDLPAVSEKD +DL+F VEQ VD+VFASFIR A  V+ +RK+LGEKGK I IISK+EN EG+ +FDEILEASDGIMVARGDLGIEIP EKV  AQKMMI +CN  GK +ICAT MLESMI K RPTRAE SDVANAV+DG+DC+MLSGE+AKG YP+E+V   H I REAE   F    FE ++ T +L  D T S A+ AVEA+ +C A+ II LT +G SA+L+++YRP  PI+ +TRN  T+RQ HL+RG+ PIL++ P  + W +D+DLR++F++     R + K+ D+II+VTG + GSG TNT+++V
Sbjct:   11 FIQTQQMPAAMAETFLEHLCLLDIDSEPTVSRNTGIVCTLGPASRSLETLREMILSGMNVARLNFSHGTHEYHAETIKSVREAIESFGAGTIDYR-PVAIALDTKGPEIRTGLIKGSGTEEVKLVKGNIIKLTLDDKFMDNCDENTLWLDYKNITKVVQQGSHIYVDDGLISLKVKEIGSDFLNCEIENGGMLGSKKGVNLPGANVDLPAVSEKDIKDLQFGVEQGVDMVFASFIRKAADVHAVRKVLGEKGKDIRIISKLENHEGVRKFDEILEASDGIMVARGDLGIEIPTEKVFLAQKMMISRCNRIGKPIICATQMLESMIKKPRPTRAESSDVANAVLDGADCIMLSGETAKGEYPIESVLTQHLIAREAEAAMFHRQLFEELRRTSHLTRDPTESVAVGAVEASFKCCASAIICLTKTGRSAQLLSRYRPRAPIMAVTRNGQTSRQLHLYRGVIPILYTKPANDIWAEDVDLRVSFALEIGKHRKYFKSGDVIIVVTGWRPGSGYTNTMRIV 527

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Query:  199 FFQERRRVHKDYATNLELVADLNIDSDPGVIRNTGIICTLGPACASVAILHKMIAAGMNVARLNFSHGTHEDHARSIKLLREAIATLKP----YRFPIAIALDTKGPEIRTGLINNNETGEVRLKKGNNIKLVVSEEYYRKCDENFIWVDYKSILKLLKVGNRIFIDDGLISLIVEEKDSEFLLCRIENGGMLGSRKGVNLPGVNVDLPAVSEKDKEDLKFAVEQNVDIVFASFIRNAESVNIIRKILGEKGKHILIISKIENQEGMIQFDEILEASDGIMVARGDLGIEIPPEKVICAQKMMIGKCNVAGKSVICATHMLESMITKSRPTRAEISDVANAVIDGSDCVMLSGESAKGRYPVEAVKMMHTICREAEHLFFQSNFFESIKETVNLPTDHTHSTAIAAVEAAQRCNAAVIIVLTTSGTSAKLIAKYRPSCPILTLTRNPITARQAHLWRGLHPILFSDPRKEEWPKDMDLRINFSINYAYQRGFVKALDIIIIVTGSKAGSGSTNTLQVV 1740
            F Q ++       T LE +  L+IDS+P V RNTGI+CTLGPA  S+  L +MI +GMNVARLNFSHGTHE HA +IK +REAI +       YR P+AIALDTKGPEIRTGLI  + T EV+L KGN IKL + +++   CDEN +W+DYK+I K+++ G+ I++DDGLISL V+E  S+FL C IENGGMLGS+KGVNLPG NVDLPAVSEKD +DL+F VEQ VD+VFASFIR A  V+ +RK+LGEKGK I IISK+EN EG+ +FDEILEASDGIMVARGDLGIEIP EKV  AQKMMI +CN  GK +ICAT MLESMI K RPTRAE SDVANAV+DG+DC+MLSGE+AKG YP+E+V   H I REAE   F    FE ++ T +L  D T S A+ AVEA+ +C A+ II LT +G SA+L+++YRP  PI+ +TRN  T+RQ HL+RG+ PIL++ P  + W +D+DLR++F++     R + K+ D+II+VTG + GSG TNT+++V
Sbjct:   11 FIQTQQMPAAMAETFLEHLCLLDIDSEPTVSRNTGIVCTLGPASRSLETLREMILSGMNVARLNFSHGTHEYHAETIKSVREAIESFGAGTIDYR-PVAIALDTKGPEIRTGLIKGSGTEEVKLVKGNIIKLTLDDKFMDNCDENTLWLDYKNITKVVQQGSHIYVDDGLISLKVKEIGSDFLNCEIENGGMLGSKKGVNLPGANVDLPAVSEKDIKDLQFGVEQGVDMVFASFIRKAADVHAVRKVLGEKGKDIRIISKLENHEGVRKFDEILEASDGIMVARGDLGIEIPTEKVFLAQKMMISRCNRIGKPIICATQMLESMIKKPRPTRAESSDVANAVLDGADCIMLSGETAKGEYPIESVLTQHLIAREAEAAMFHRQLFEELRRTSHLTRDPTESVAVGAVEASFKCCASAIICLTKTGRSAQLLSRYRPRAPIMAVTRNGQTSRQLHLYRGVIPILYTKPANDIWAEDVDLRVSFALEIGKHRKYFKSGDVIIVVTGWRPGSGYTNTMRIV 527

[Close]

BLAST of Pyruvate kinase vs. Ensembl Xenopus
Match: pkm (pyruvate kinase M1/2 [Source:NCBI gene;Acc:549224])

HSP 1 Score: 630.943 bits (1626), Expect = 0.000e+0
Identity = 313/525 (59.62%), Postives = 403/525 (76.76%), Query Frame = 1

Query:  187 QSNYFFQERRRVHKDYA-TNLELVADLNIDSDPGVIRNTGIICTLGPACASVAILHKMIAAGMNVARLNFSHGTHEDHARSIKLLREAIATLKP----YRFPIAIALDTKGPEIRTGLINNNETGEVRLKKGNNIKLVVSEEYYRKCDENFIWVDYKSILKLLKVGNRIFIDDGLISLIVEEKDSEFLLCRIENGGMLGSRKGVNLPGVNVDLPAVSEKDKEDLKFAVEQNVDIVFASFIRNAESVNIIRKILGEKGKHILIISKIENQEGMIQFDEILEASDGIMVARGDLGIEIPPEKVICAQKMMIGKCNVAGKSVICATHMLESMITKSRPTRAEISDVANAVIDGSDCVMLSGESAKGRYPVEAVKMMHTICREAEHLFFQSNFFESIKETVNLPTDHTHSTAIAAVEAAQRCNAAVIIVLTTSGTSAKLIAKYRPSCPILTLTRNPITARQAHLWRGLHPILFSDPRKEEWPKDMDLRINFSINYAYQRGFVKALDIIIIVTGSKAGSGSTNTLQVVKL 1746
            +S+ F Q ++ +H   A T LE +  L+IDS+P V RNTGIICT+GPA  SV IL +MI +GMN+ARLNFSHGTHE HA +IK +REA  +       YR P+A+ALDTKGPEIRTGLI  + T EV LKKG  +++ + + +  KCDEN +WVDYK++ K++K G++I++DDGLISL+V+E  ++F L  +ENGGMLGS+KGVNLPG  VDLPAVS KD +DL+F VEQNVD+VFASFIR A  V+ +RK+LGEKGK+I IISKIEN EG+ +FDEILEASDGIMVARGDLGIEIP EKV  AQKMMIG+CN AGK VICAT MLESMI K RPTRAE SDVANAV+DG+DC+MLSGE+AKG YP+EAV+M H I REAE   F    FE ++    L  D T +TA+ AVE++ +C++  IIVLT SG SA L+++YRP  PI+ +TRN  TARQAHL+RG+ P+L+ +   E W +D+D+R+NF+++    RGF K+ D++I++TG + GSG TNT++VV +
Sbjct:    5 KSSAFIQTQQ-LHAAMADTFLEHMCRLDIDSEPIVARNTGIICTIGPASRSVEILKEMIKSGMNIARLNFSHGTHEYHAGTIKNVREATESFSSNPIHYR-PVAVALDTKGPEIRTGLIKGSGTAEVELKKGATLRITLDDAFQEKCDENILWVDYKNLTKVVKPGSKIYVDDGLISLLVKETGADFCLTEVENGGMLGSKKGVNLPGAAVDLPAVSTKDIQDLQFGVEQNVDMVFASFIRKAADVHAVRKVLGEKGKNIKIISKIENHEGVRRFDEILEASDGIMVARGDLGIEIPAEKVFLAQKMMIGRCNRAGKPVICATQMLESMIKKPRPTRAEGSDVANAVLDGADCIMLSGETAKGDYPLEAVRMQHAIAREAEAAIFHRQLFEELRRVSPLTRDPTEATAVGAVESSFKCSSGAIIVLTKSGRSAHLVSRYRPRAPIIAVTRNGQTARQAHLYRGIFPVLYREAVHEAWAEDVDMRVNFAMDIGKARGFFKSGDVVIVLTGWRPGSGFTNTMRVVPV 527

[Close]

BLAST of Pyruvate kinase vs. Ensembl Xenopus
Match: pkm (pyruvate kinase M1/2 [Source:NCBI gene;Acc:549224])

HSP 1 Score: 630.558 bits (1625), Expect = 0.000e+0
Identity = 311/520 (59.81%), Postives = 400/520 (76.92%), Query Frame = 1

Query:  202 FQERRRVHKDYA-TNLELVADLNIDSDPGVIRNTGIICTLGPACASVAILHKMIAAGMNVARLNFSHGTHEDHARSIKLLREAIATLKP----YRFPIAIALDTKGPEIRTGLINNNETGEVRLKKGNNIKLVVSEEYYRKCDENFIWVDYKSILKLLKVGNRIFIDDGLISLIVEEKDSEFLLCRIENGGMLGSRKGVNLPGVNVDLPAVSEKDKEDLKFAVEQNVDIVFASFIRNAESVNIIRKILGEKGKHILIISKIENQEGMIQFDEILEASDGIMVARGDLGIEIPPEKVICAQKMMIGKCNVAGKSVICATHMLESMITKSRPTRAEISDVANAVIDGSDCVMLSGESAKGRYPVEAVKMMHTICREAEHLFFQSNFFESIKETVNLPTDHTHSTAIAAVEAAQRCNAAVIIVLTTSGTSAKLIAKYRPSCPILTLTRNPITARQAHLWRGLHPILFSDPRKEEWPKDMDLRINFSINYAYQRGFVKALDIIIIVTGSKAGSGSTNTLQVVKL 1746
            F + +++H   A T LE +  L+IDS+P V RNTGIICT+GPA  SV IL +MI +GMN+ARLNFSHGTHE HA +IK +REA  +       YR P+A+ALDTKGPEIRTGLI  + T EV LKKG  +++ + + +  KCDEN +WVDYK++ K++K G++I++DDGLISL+V+E  ++F L  +ENGGMLGS+KGVNLPG  VDLPAVS KD +DL+F VEQNVD+VFASFIR A  V+ +RK+LGEKGK+I IISKIEN EG+ +FDEILEASDGIMVARGDLGIEIP EKV  AQKMMIG+CN AGK VICAT MLESMI K RPTRAE SDVANAV+DG+DC+MLSGE+AKG YP+EAV+M H I REAE   F    FE ++    L  D T +TA+ AVE++ +C++  IIVLT SG SA L+++YRP  PI+ +TRN  TARQAHL+RG+ P+L+ +   E W +D+D+R+NF+++    RGF K+ D++I++TG + GSG TNT++VV +
Sbjct:    9 FIQTQQLHAAMADTFLEHMCRLDIDSEPIVARNTGIICTIGPASRSVEILKEMIKSGMNIARLNFSHGTHEYHAGTIKNVREATESFSSNPIHYR-PVAVALDTKGPEIRTGLIKGSGTAEVELKKGATLRITLDDAFQEKCDENILWVDYKNLTKVVKPGSKIYVDDGLISLLVKETGADFCLTEVENGGMLGSKKGVNLPGAAVDLPAVSTKDIQDLQFGVEQNVDMVFASFIRKAADVHAVRKVLGEKGKNIKIISKIENHEGVRRFDEILEASDGIMVARGDLGIEIPAEKVFLAQKMMIGRCNRAGKPVICATQMLESMIKKPRPTRAEGSDVANAVLDGADCIMLSGETAKGDYPLEAVRMQHAIAREAEAAIFHRQLFEELRRVSPLTRDPTEATAVGAVESSFKCSSGAIIVLTKSGRSAHLVSRYRPRAPIIAVTRNGQTARQAHLYRGIFPVLYREAVHEAWAEDVDMRVNFAMDIGKARGFFKSGDVVIVLTGWRPGSGFTNTMRVVPV 527

[Close]

BLAST of Pyruvate kinase vs. Ensembl Xenopus
Match: pkm (pyruvate kinase M1/2 [Source:NCBI gene;Acc:549224])

HSP 1 Score: 629.787 bits (1623), Expect = 0.000e+0
Identity = 311/520 (59.81%), Postives = 400/520 (76.92%), Query Frame = 1

Query:  202 FQERRRVHKDYA-TNLELVADLNIDSDPGVIRNTGIICTLGPACASVAILHKMIAAGMNVARLNFSHGTHEDHARSIKLLREAIATLKP----YRFPIAIALDTKGPEIRTGLINNNETGEVRLKKGNNIKLVVSEEYYRKCDENFIWVDYKSILKLLKVGNRIFIDDGLISLIVEEKDSEFLLCRIENGGMLGSRKGVNLPGVNVDLPAVSEKDKEDLKFAVEQNVDIVFASFIRNAESVNIIRKILGEKGKHILIISKIENQEGMIQFDEILEASDGIMVARGDLGIEIPPEKVICAQKMMIGKCNVAGKSVICATHMLESMITKSRPTRAEISDVANAVIDGSDCVMLSGESAKGRYPVEAVKMMHTICREAEHLFFQSNFFESIKETVNLPTDHTHSTAIAAVEAAQRCNAAVIIVLTTSGTSAKLIAKYRPSCPILTLTRNPITARQAHLWRGLHPILFSDPRKEEWPKDMDLRINFSINYAYQRGFVKALDIIIIVTGSKAGSGSTNTLQVVKL 1746
            F + +++H   A T LE +  L+IDS+P V RNTGIICT+GPA  SV IL +MI +GMN+ARLNFSHGTHE HA +IK +REA  +       YR P+A+ALDTKGPEIRTGLI  + T EV LKKG  +++ + + +  KCDEN +WVDYK++ K++K G++I++DDGLISL+V+E  ++F L  +ENGGMLGS+KGVNLPG  VDLPAVS KD +DL+F VEQNVD+VFASFIR A  V+ +RK+LGEKGK+I IISKIEN EG+ +FDEILEASDGIMVARGDLGIEIP EKV  AQKMMIG+CN AGK VICAT MLESMI K RPTRAE SDVANAV+DG+DC+MLSGE+AKG YP+EAV+M H I REAE   F    FE ++    L  D T +TA+ AVE++ +C++  IIVLT SG SA L+++YRP  PI+ +TRN  TARQAHL+RG+ P+L+ +   E W +D+D+R+NF+++    RGF K+ D++I++TG + GSG TNT++VV +
Sbjct:   11 FIQTQQLHAAMADTFLEHMCRLDIDSEPIVARNTGIICTIGPASRSVEILKEMIKSGMNIARLNFSHGTHEYHAGTIKNVREATESFSSNPIHYR-PVAVALDTKGPEIRTGLIKGSGTAEVELKKGATLRITLDDAFQEKCDENILWVDYKNLTKVVKPGSKIYVDDGLISLLVKETGADFCLTEVENGGMLGSKKGVNLPGAAVDLPAVSTKDIQDLQFGVEQNVDMVFASFIRKAADVHAVRKVLGEKGKNIKIISKIENHEGVRRFDEILEASDGIMVARGDLGIEIPAEKVFLAQKMMIGRCNRAGKPVICATQMLESMIKKPRPTRAEGSDVANAVLDGADCIMLSGETAKGDYPLEAVRMQHAIAREAEAAIFHRQLFEELRRVSPLTRDPTEATAVGAVESSFKCSSGAIIVLTKSGRSAHLVSRYRPRAPIIAVTRNGQTARQAHLYRGIFPVLYREAVHEAWAEDVDMRVNFAMDIGKARGFFKSGDVVIVLTGWRPGSGFTNTMRVVPV 529

[Close]

BLAST of Pyruvate kinase vs. Ensembl Xenopus
Match: pkm (pyruvate kinase M1/2 [Source:NCBI gene;Acc:549224])

HSP 1 Score: 626.32 bits (1614), Expect = 0.000e+0
Identity = 312/520 (60.00%), Postives = 399/520 (76.73%), Query Frame = 1

Query:  202 FQERRRVHKDYA-TNLELVADLNIDSDPGVIRNTGIICTLGPACASVAILHKMIAAGMNVARLNFSHGTHEDHARSIKLLREAIATLKP----YRFPIAIALDTKGPEIRTGLINNNETGEVRLKKGNNIKLVVSEEYYRKCDENFIWVDYKSILKLLKVGNRIFIDDGLISLIVEEKDSEFLLCRIENGGMLGSRKGVNLPGVNVDLPAVSEKDKEDLKFAVEQNVDIVFASFIRNAESVNIIRKILGEKGKHILIISKIENQEGMIQFDEILEASDGIMVARGDLGIEIPPEKVICAQKMMIGKCNVAGKSVICATHMLESMITKSRPTRAEISDVANAVIDGSDCVMLSGESAKGRYPVEAVKMMHTICREAEHLFFQSNFFESIKETVNLPTDHTHSTAIAAVEAAQRCNAAVIIVLTTSGTSAKLIAKYRPSCPILTLTRNPITARQAHLWRGLHPILFSDPRKEEWPKDMDLRINFSINYAYQRGFVKALDIIIIVTGSKAGSGSTNTLQVVKL 1746
            F + +++H   A T LE +  L+IDS+P V RNTGIICT+GPA  SV IL +MI +GMN+ARLNFSHGTHE HA +IK +REA  +       YR P+A+ALDTKGPEIRTGLI  + T EV LKKG  +++ + + +  KCDEN +WVDYK++ K++K G++I++DDGLISL+V+E D  F L  +ENGGMLGS+KGVNLPG  VDLPAVS KD +DL+F VEQNVD+VFASFIR A  V+ +RK+LGEKGK+I IISKIEN EG+ +FDEILEASDGIMVARGDLGIEIP EKV  AQKMMIG+CN AGK VICAT MLESMI K RPTRAE SDVANAV+DG+DC+MLSGE+AKG YP+EAV+M H I REAE   F    FE ++    L  D T +TA+ AVE++ +C++  IIVLT SG SA L+++YRP  PI+ +TRN  TARQAHL+RG+ P+L+ +   E W +D+D+R+NF+++    RGF K+ D++I++TG + GSG TNT++VV +
Sbjct:   18 FIQTQQLHAAMADTFLEHMCRLDIDSEPIVARNTGIICTIGPASRSVEILKEMIKSGMNIARLNFSHGTHEYHAGTIKNVREATESFSSNPIHYR-PVAVALDTKGPEIRTGLIKGSGTAEVELKKGATLRITLDDAFQEKCDENILWVDYKNLTKVVKPGSKIYVDDGLISLLVKETD--FCLTEVENGGMLGSKKGVNLPGAAVDLPAVSTKDIQDLQFGVEQNVDMVFASFIRKAADVHAVRKVLGEKGKNIKIISKIENHEGVRRFDEILEASDGIMVARGDLGIEIPAEKVFLAQKMMIGRCNRAGKPVICATQMLESMIKKPRPTRAEGSDVANAVLDGADCIMLSGETAKGDYPLEAVRMQHAIAREAEAAIFHRQLFEELRRVSPLTRDPTEATAVGAVESSFKCSSGAIIVLTKSGRSAHLVSRYRPRAPIIAVTRNGQTARQAHLYRGIFPVLYREAVHEAWAEDVDMRVNFAMDIGKARGFFKSGDVVIVLTGWRPGSGFTNTMRVVPV 534

[Close]

BLAST of Pyruvate kinase vs. Ensembl Xenopus
Match: pkm (pyruvate kinase M1/2 [Source:NCBI gene;Acc:549224])

HSP 1 Score: 624.394 bits (1609), Expect = 0.000e+0
Identity = 310/549 (56.47%), Postives = 400/549 (72.86%), Query Frame = 1

Query:  202 FQERRRVHKDYA-TNLELVADLNIDSDPGVIRNTGIICTLGPACASVAILHKMIAAGMNVARLNFSHGTHEDHARSIKLLREAIATLKP----YRFPIAIALDTKGPEIRTGLINNNETGEVRLKKGNNIKLVVSEEYYRKCDENFIWVDYKSILKLLKVGNRIFIDDGLISLIVEEKDSEFLLCRIENGGMLGSRKGVNLPGVNVDLPAVSEKDKEDLKFAVEQNVDIVFASFIRNAESVNIIRKILGEKGKHILIISKIENQEGMIQFDEILEASDGIMVARGDLGIEIPPEKVICAQKMMIGKCNVAGKSVICATHMLESMITKSRPTRAEISDVANAVIDGSDCVMLSGESAKGRYPVEAVKMMHT-----------------------------ICREAEHLFFQSNFFESIKETVNLPTDHTHSTAIAAVEAAQRCNAAVIIVLTTSGTSAKLIAKYRPSCPILTLTRNPITARQAHLWRGLHPILFSDPRKEEWPKDMDLRINFSINYAYQRGFVKALDIIIIVTGSKAGSGSTNTLQVVKL 1746
            F + +++H   A T LE +  L+IDS+P V RNTGIICT+GPA  SV IL +MI +GMN+ARLNFSHGTHE HA +IK +REA  +       YR P+A+ALDTKGPEIRTGLI  + T EV LKKG  +++ + + +  KCDEN +WVDYK++ K++K G++I++DDGLISL+V+E  ++F L  +ENGGMLGS+KGVNLPG  VDLPAVS KD +DL+F VEQNVD+VFASFIR A  V+ +RK+LGEKGK+I IISKIEN EG+ +FDEILEASDGIMVARGDLGIEIP EKV  AQKMMIG+CN AGK VICAT MLESMI K RPTRAE SDVANAV+DG+DC+MLSGE+AKG YP+EAV+M  +                             I REAE   F    FE ++    L  D T +TA+ AVE++ +C++  IIVLT SG SA L+++YRP  PI+ +TRN  TARQAHL+RG+ P+L+ +   E W +D+D+R+NF+++    RGF K+ D++I++TG + GSG TNT++VV +
Sbjct:    8 FIQTQQLHAAMADTFLEHMCRLDIDSEPIVARNTGIICTIGPASRSVEILKEMIKSGMNIARLNFSHGTHEYHAGTIKNVREATESFSSNPIHYR-PVAVALDTKGPEIRTGLIKGSGTAEVELKKGATLRITLDDAFQEKCDENILWVDYKNLTKVVKPGSKIYVDDGLISLLVKETGADFCLTEVENGGMLGSKKGVNLPGAAVDLPAVSTKDIQDLQFGVEQNVDMVFASFIRKAADVHAVRKVLGEKGKNIKIISKIENHEGVRRFDEILEASDGIMVARGDLGIEIPAEKVFLAQKMMIGRCNRAGKPVICATQMLESMIKKPRPTRAEGSDVANAVLDGADCIMLSGETAKGDYPLEAVRMQESLSCIFCLWFVSPFFSYAVFLVVLPSGPQIIAREAEAAIFHRQLFEELRRVSPLTRDPTEATAVGAVESSFKCSSGAIIVLTKSGRSAHLVSRYRPRAPIIAVTRNGQTARQAHLYRGIFPVLYREAVHEAWAEDVDMRVNFAMDIGKARGFFKSGDVVIVLTGWRPGSGFTNTMRVVPV 555

[Close]

BLAST of Pyruvate kinase vs. Ensembl Mouse
Match: Pkm (pyruvate kinase, muscle [Source:MGI Symbol;Acc:MGI:97591])

HSP 1 Score: 632.484 bits (1630), Expect = 0.000e+0
Identity = 313/523 (59.85%), Postives = 394/523 (75.33%), Query Frame = 1

Query:  187 QSNYFFQERRRVHKDYA-TNLELVADLNIDSDPGVIRNTGIICTLGPACASVAILHKMIAAGMNVARLNFSHGTHEDHARSIKLLREAIATLKP----YRFPIAIALDTKGPEIRTGLINNNETGEVRLKKGNNIKLVVSEEYYRKCDENFIWVDYKSILKLLKVGNRIFIDDGLISLIVEEKDSEFLLCRIENGGMLGSRKGVNLPGVNVDLPAVSEKDKEDLKFAVEQNVDIVFASFIRNAESVNIIRKILGEKGKHILIISKIENQEGMIQFDEILEASDGIMVARGDLGIEIPPEKVICAQKMMIGKCNVAGKSVICATHMLESMITKSRPTRAEISDVANAVIDGSDCVMLSGESAKGRYPVEAVKMMHTICREAEHLFFQSNFFESIKETVNLPTDHTHSTAIAAVEAAQRCNAAVIIVLTTSGTSAKLIAKYRPSCPILTLTRNPITARQAHLWRGLHPILFSDPRKEEWPKDMDLRINFSINYAYQRGFVKALDIIIIVTGSKAGSGSTNTLQVV 1740
            ++   F + +++H   A T LE +  L+IDS P   RNTGIICT+GPA  SV +L +MI +GMNVARLNFSHGTHE HA +IK +REA  +       YR P+A+ALDTKGPEIRTGLI  + T EV LKKG  +K+ +   Y  KCDEN +W+DYK+I K+++VG++I++DDGLISL V+EK ++FL+  +ENGG LGS+KGVNLPG  VDLPAVSEKD +DLKF VEQ+VD+VFASFIR A  V+ +RK+LGEKGK+I IISKIEN EG+ +FDEILEASDGIMVARGDLGIEIP EKV  AQKMMIG+CN AGK VICAT MLESMI K RPTRAE SDVANAV+DG+DC+MLSGE+AKG YP+EAV+M H I REAE   F    FE +    +  TD   + A+ +VEA+ +C AA +IVLT SG SA  +A+YRP  PI+ +TRNP TARQAHL+RG+ P+L  D     W +D+DLR+N +++    RGF K  D++I++TG + GSG TNT++VV
Sbjct:    7 EAGTAFIQTQQLHAAMADTFLEHMCRLDIDSAPITARNTGIICTIGPASRSVEMLKEMIKSGMNVARLNFSHGTHEYHAETIKNVREATESFASDPILYR-PVAVALDTKGPEIRTGLIKGSGTAEVELKKGATLKITLDNAYMEKCDENILWLDYKNICKVVEVGSKIYVDDGLISLQVKEKGADFLVTEVENGGSLGSKKGVNLPGAAVDLPAVSEKDIQDLKFGVEQDVDMVFASFIRKAADVHEVRKVLGEKGKNIKIISKIENHEGVRRFDEILEASDGIMVARGDLGIEIPAEKVFLAQKMMIGRCNRAGKPVICATQMLESMIKKPRPTRAEGSDVANAVLDGADCIMLSGETAKGDYPLEAVRMQHLIAREAEAAMFHRLLFEELVRASSHSTDLMEAMAMGSVEASYKCLAAALIVLTESGRSAHQVARYRPRAPIIAVTRNPQTARQAHLYRGIFPVLCKDAVLNAWAEDVDLRVNLAMDVGKARGFFKKGDVVIVLTGWRPGSGFTNTMRVV 528

[Close]

BLAST of Pyruvate kinase vs. Ensembl Mouse
Match: Pkm (pyruvate kinase, muscle [Source:MGI Symbol;Acc:MGI:97591])

HSP 1 Score: 621.313 bits (1601), Expect = 0.000e+0
Identity = 312/525 (59.43%), Postives = 396/525 (75.43%), Query Frame = 1

Query:  187 QSNYFFQERRRVHKDYA-TNLELVADLNIDSDPGVIRNTGIICTLGPACASVAILHKMIAAGMNVARLNFSHGTHEDHARSIKLLREAIATLKP----YRFPIAIALDTKGPEIRTGLINNNETGEVRLKKGNNIKLVVSEEYYRKCDENFIWVDYKSILKLLKVGNRIFIDDGLISLIVEEKDSEFLLCRIENGGMLGSRKGVNLPGVNVDLPAVSEKDKEDLKFAVEQNVDIVFASFIRNAESVNIIRKILGEKGKHILIISKIENQEGMIQFDEILEASDGIMVARGDLGIEIPPEKVICAQKMMIGKCNVAGKSVICATHMLESMITKSRPTRAEISDVANAVIDGSDCVMLSGESAKGRYPVEAVKMMHTICREAEHLFFQSNFFESIKETVNLPTDHTHSTAIAAVEAAQRCNAAVIIVLTTSGTSAKLIAKYRPSCPILTLTRNPITARQAHLWRGLHPILFSDPRKEEWPKDMDLRINFSINYAYQRGFVKALDIIIIVTGSKAGSGSTNTLQVVKL 1746
            ++   F + +++H   A T LE +  L+IDS P   RNTGIICT+GPA  SV +L +MI +GMNVARLNFSHGTHE HA +IK +REA  +       YR P+A+ALDTKGPEIRTGLI  + T EV LKKG  +K+ +   Y  KCDEN +W+DYK+I K+++VG++I++DDGLISL V+EK ++FL+  +ENGG LGS+KGVNLPG  VDLPAVSEKD +DLKF VEQ+VD+VFASFIR A  V+ +RK+LGEKGK+I IISKIEN EG+ +FDEILEASDGIMVARGDLGIEIP EKV  AQKMMIG+CN AGK VICAT MLESMI K RPTRAE SDVANAV+DG+DC+MLSGE+AKG YP+EAV+M H I REAE   +    FE ++    + +D T + A+ AVEA+ +C +  IIVLT SG SA  +A+YRP  PI+ +TRNP TARQAHL+RG+ P+L  D     W +D+DLR+N +++    RGF K  D++I++TG + GSG TNT++VV +
Sbjct:    7 EAGTAFIQTQQLHAAMADTFLEHMCRLDIDSAPITARNTGIICTIGPASRSVEMLKEMIKSGMNVARLNFSHGTHEYHAETIKNVREATESFASDPILYR-PVAVALDTKGPEIRTGLIKGSGTAEVELKKGATLKITLDNAYMEKCDENILWLDYKNICKVVEVGSKIYVDDGLISLQVKEKGADFLVTEVENGGSLGSKKGVNLPGAAVDLPAVSEKDIQDLKFGVEQDVDMVFASFIRKAADVHEVRKVLGEKGKNIKIISKIENHEGVRRFDEILEASDGIMVARGDLGIEIPAEKVFLAQKMMIGRCNRAGKPVICATQMLESMIKKPRPTRAEGSDVANAVLDGADCIMLSGETAKGDYPLEAVRMQHLIAREAEAAIYHLQLFEELRRLAPITSDPTEAAAVGAVEASFKCCSGAIIVLTKSGRSAHQVARYRPRAPIIAVTRNPQTARQAHLYRGIFPVLCKDAVLNAWAEDVDLRVNLAMDVGKARGFFKKGDVVIVLTGWRPGSGFTNTMRVVPV 530

[Close]

BLAST of Pyruvate kinase vs. Ensembl Mouse
Match: Pklr (pyruvate kinase liver and red blood cell [Source:MGI Symbol;Acc:MGI:97604])

HSP 1 Score: 573.933 bits (1478), Expect = 0.000e+0
Identity = 283/524 (54.01%), Postives = 369/524 (70.42%), Query Frame = 1

Query:  184 EQSNYFFQERRRVHKDYATNLELVADLNIDSDPGVIRNTGIICTLGPACASVAILHKMIAAGMNVARLNFSHGTHEDHARSIKLLREAIATL--KPYRF-PIAIALDTKGPEIRTGLINNNETGEVRLKKGNNIKLVVSEEYYRKCDENFIWVDYKSILKLLKVGNRIFIDDGLISLIVEEKDSEFLLCRIENGGMLGSRKGVNLPGVNVDLPAVSEKDKEDLKFAVEQNVDIVFASFIRNAESVNIIRKILGEKGKHILIISKIENQEGMIQFDEILEASDGIMVARGDLGIEIPPEKVICAQKMMIGKCNVAGKSVICATHMLESMITKSRPTRAEISDVANAVIDGSDCVMLSGESAKGRYPVEAVKMMHTICREAEHLFFQSNFFESIKETVNLPTDHTHSTAIAAVEAAQRCNAAVIIVLTTSGTSAKLIAKYRPSCPILTLTRNPITARQAHLWRGLHPILFSDPRKEEWPKDMDLRINFSINYAYQRGFVKALDIIIIVTGSKAGSGSTNTLQVVKL 1746
            E    FFQ+++       T LE +  L+IDS+P   R+T II T+GPA  SV  L +MI AGMN+ARLNFSHG+HE HA SI  +REA  +    P  + P+AIALDTKGPEIRTG++      EV + KG+ + + V  ++  + D   +WVDY +I +++ VG RI+IDDGLISL+V +   E L+  +E+GG LG+RKGVNLP   VDLP +SE+D  DL+F VE NVDI+FASF+R A  V  +R  LG +G+ I IISKIEN EG+ +FDEILE SDGIMVARGDLGIEIP EKV  AQKMMIG+CN+AGK V+CAT MLESMITK+RPTRAE SDVANAV+DG+DC+MLSGE+AKG +PVEAVKM H I REAE   +    FE ++    L  D T  TAI AVEA+ +C AA IIVLT +G SA+L+++YRP   ++ +TR+   ARQ HL RG+ P+L+ +P +  W  D+D R+ F I     RGF++  D++I+VTG + GSG TN ++V+ +
Sbjct:   19 ELGTAFFQQQQLPAAMADTFLEHLCLLDIDSEPVAARSTSIIATIGPASRSVDRLKEMIKAGMNIARLNFSHGSHEYHAESIANIREAAESFATSPLSYRPVAIALDTKGPEIRTGVLQGGPESEVEIVKGSQVLVTVDPKFRTRGDAKTVWVDYHNITQVVAVGGRIYIDDGLISLVVRKIGPEGLVTEVEHGGFLGNRKGVNLPNAEVDLPGLSEQDLLDLRFGVEHNVDIIFASFVRKASDVVAVRDALGPEGRGIKIISKIENHEGVKKFDEILEVSDGIMVARGDLGIEIPAEKVFLAQKMMIGRCNLAGKPVVCATQMLESMITKARPTRAETSDVANAVLDGADCIMLSGETAKGSFPVEAVKMQHAIAREAEAAVYHRQLFEELRRAAPLSRDPTEVTAIGAVEASFKCCAAAIIVLTKTGRSAQLLSRYRPRAAVIAVTRSAQAARQVHLSRGVFPLLYREPPEAVWADDVDRRVQFGIESGKLRGFLRVGDLVIVVTGWRPGSGYTNIMRVLTI 542

[Close]

BLAST of Pyruvate kinase vs. Ensembl Mouse
Match: Pklr (pyruvate kinase liver and red blood cell [Source:MGI Symbol;Acc:MGI:97604])

HSP 1 Score: 573.548 bits (1477), Expect = 0.000e+0
Identity = 283/524 (54.01%), Postives = 369/524 (70.42%), Query Frame = 1

Query:  184 EQSNYFFQERRRVHKDYATNLELVADLNIDSDPGVIRNTGIICTLGPACASVAILHKMIAAGMNVARLNFSHGTHEDHARSIKLLREAIATL--KPYRF-PIAIALDTKGPEIRTGLINNNETGEVRLKKGNNIKLVVSEEYYRKCDENFIWVDYKSILKLLKVGNRIFIDDGLISLIVEEKDSEFLLCRIENGGMLGSRKGVNLPGVNVDLPAVSEKDKEDLKFAVEQNVDIVFASFIRNAESVNIIRKILGEKGKHILIISKIENQEGMIQFDEILEASDGIMVARGDLGIEIPPEKVICAQKMMIGKCNVAGKSVICATHMLESMITKSRPTRAEISDVANAVIDGSDCVMLSGESAKGRYPVEAVKMMHTICREAEHLFFQSNFFESIKETVNLPTDHTHSTAIAAVEAAQRCNAAVIIVLTTSGTSAKLIAKYRPSCPILTLTRNPITARQAHLWRGLHPILFSDPRKEEWPKDMDLRINFSINYAYQRGFVKALDIIIIVTGSKAGSGSTNTLQVVKL 1746
            E    FFQ+++       T LE +  L+IDS+P   R+T II T+GPA  SV  L +MI AGMN+ARLNFSHG+HE HA SI  +REA  +    P  + P+AIALDTKGPEIRTG++      EV + KG+ + + V  ++  + D   +WVDY +I +++ VG RI+IDDGLISL+V +   E L+  +E+GG LG+RKGVNLP   VDLP +SE+D  DL+F VE NVDI+FASF+R A  V  +R  LG +G+ I IISKIEN EG+ +FDEILE SDGIMVARGDLGIEIP EKV  AQKMMIG+CN+AGK V+CAT MLESMITK+RPTRAE SDVANAV+DG+DC+MLSGE+AKG +PVEAVKM H I REAE   +    FE ++    L  D T  TAI AVEA+ +C AA IIVLT +G SA+L+++YRP   ++ +TR+   ARQ HL RG+ P+L+ +P +  W  D+D R+ F I     RGF++  D++I+VTG + GSG TN ++V+ +
Sbjct:   50 ELGTAFFQQQQLPAAMADTFLEHLCLLDIDSEPVAARSTSIIATIGPASRSVDRLKEMIKAGMNIARLNFSHGSHEYHAESIANIREAAESFATSPLSYRPVAIALDTKGPEIRTGVLQGGPESEVEIVKGSQVLVTVDPKFRTRGDAKTVWVDYHNITQVVAVGGRIYIDDGLISLVVRKIGPEGLVTEVEHGGFLGNRKGVNLPNAEVDLPGLSEQDLLDLRFGVEHNVDIIFASFVRKASDVVAVRDALGPEGRGIKIISKIENHEGVKKFDEILEVSDGIMVARGDLGIEIPAEKVFLAQKMMIGRCNLAGKPVVCATQMLESMITKARPTRAETSDVANAVLDGADCIMLSGETAKGSFPVEAVKMQHAIAREAEAAVYHRQLFEELRRAAPLSRDPTEVTAIGAVEASFKCCAAAIIVLTKTGRSAQLLSRYRPRAAVIAVTRSAQAARQVHLSRGVFPLLYREPPEAVWADDVDRRVQFGIESGKLRGFLRVGDLVIVVTGWRPGSGYTNIMRVLTI 573

[Close]

BLAST of Pyruvate kinase vs. Ensembl Mouse
Match: Pkm (pyruvate kinase, muscle [Source:MGI Symbol;Acc:MGI:97591])

HSP 1 Score: 260.381 bits (664), Expect = 5.151e-82
Identity = 130/222 (58.56%), Postives = 166/222 (74.77%), Query Frame = 1

Query:  202 FQERRRVHKDYA-TNLELVADLNIDSDPGVIRNTGIICTLGPACASVAILHKMIAAGMNVARLNFSHGTHEDHARSIKLLREAIATLKP----YRFPIAIALDTKGPEIRTGLINNNETGEVRLKKGNNIKLVVSEEYYRKCDENFIWVDYKSILKLLKVGNRIFIDDGLISLIVEEKDSEFLLCRIENGGMLGSRKGVNLPGVNVDLPAVSEKDKEDLKFA 852
            F + +++H   A T LE +  L+IDS P   RNTGIICT+GPA  SV +L +MI +GMNVARLNFSHGTHE HA +IK +REA  +       YR P+A+ALDTKGPEIRTGLI  + T EV LKKG  +K+ +   Y  KCDEN +W+DYK+I K+++VG++I++DDGLISL V+EK ++FL+  +ENGG LGS+KGVNLPG  VDLPAVSEKD +DLKF 
Sbjct:   12 FIQTQQLHAAMADTFLEHMCRLDIDSAPITARNTGIICTIGPASRSVEMLKEMIKSGMNVARLNFSHGTHEYHAETIKNVREATESFASDPILYR-PVAVALDTKGPEIRTGLIKGSGTAEVELKKGATLKITLDNAYMEKCDENILWLDYKNICKVVEVGSKIYVDDGLISLQVKEKGADFLVTEVENGGSLGSKKGVNLPGAAVDLPAVSEKDIQDLKFG 232

[Close]

BLAST of Pyruvate kinase vs. UniProt/SwissProt
Match: sp|P14618|KPYM_HUMAN (Pyruvate kinase PKM OS=Homo sapiens OX=9606 GN=PKM PE=1 SV=4)

HSP 1 Score: 644.04 bits (1660), Expect = 0.000e+0
Identity = 315/525 (60.00%), Postives = 399/525 (76.00%), Query Frame = 1

Query:  187 QSNYFFQERRRVHKDYA-TNLELVADLNIDSDPGVIRNTGIICTLGPACASVAILHKMIAAGMNVARLNFSHGTHEDHARSIKLLREAIATLKP----YRFPIAIALDTKGPEIRTGLINNNETGEVRLKKGNNIKLVVSEEYYRKCDENFIWVDYKSILKLLKVGNRIFIDDGLISLIVEEKDSEFLLCRIENGGMLGSRKGVNLPGVNVDLPAVSEKDKEDLKFAVEQNVDIVFASFIRNAESVNIIRKILGEKGKHILIISKIENQEGMIQFDEILEASDGIMVARGDLGIEIPPEKVICAQKMMIGKCNVAGKSVICATHMLESMITKSRPTRAEISDVANAVIDGSDCVMLSGESAKGRYPVEAVKMMHTICREAEHLFFQSNFFESIKETVNLPTDHTHSTAIAAVEAAQRCNAAVIIVLTTSGTSAKLIAKYRPSCPILTLTRNPITARQAHLWRGLHPILFSDPRKEEWPKDMDLRINFSINYAYQRGFVKALDIIIIVTGSKAGSGSTNTLQVVKL 1746
            ++   F + +++H   A T LE +  L+IDS P   RNTGIICT+GPA  SV  L +MI +GMNVARLNFSHGTHE HA +IK +R A  +       YR P+A+ALDTKGPEIRTGLI  + T EV LKKG  +K+ +   Y  KCDEN +W+DYK+I K+++VG++I++DDGLISL V++K ++FL+  +ENGG LGS+KGVNLPG  VDLPAVSEKD +DLKF VEQ+VD+VFASFIR A  V+ +RK+LGEKGK+I IISKIEN EG+ +FDEILEASDGIMVARGDLGIEIP EKV  AQKMMIG+CN AGK VICAT MLESMI K RPTRAE SDVANAV+DG+DC+MLSGE+AKG YP+EAV+M H I REAE   +    FE ++    + +D T +TA+ AVEA+ +C +  IIVLT SG SA  +A+YRP  PI+ +TRNP TARQAHL+RG+ P+L  DP +E W +D+DLR+NF++N    RGF K  D++I++TG + GSG TNT++VV +
Sbjct:    7 EAGTAFIQTQQLHAAMADTFLEHMCRLDIDSPPITARNTGIICTIGPASRSVETLKEMIKSGMNVARLNFSHGTHEYHAETIKNVRTATESFASDPILYR-PVAVALDTKGPEIRTGLIKGSGTAEVELKKGATLKITLDNAYMEKCDENILWLDYKNICKVVEVGSKIYVDDGLISLQVKQKGADFLVTEVENGGSLGSKKGVNLPGAAVDLPAVSEKDIQDLKFGVEQDVDMVFASFIRKASDVHEVRKVLGEKGKNIKIISKIENHEGVRRFDEILEASDGIMVARGDLGIEIPAEKVFLAQKMMIGRCNRAGKPVICATQMLESMIKKPRPTRAEGSDVANAVLDGADCIMLSGETAKGDYPLEAVRMQHLIAREAEAAIYHLQLFEELRRLAPITSDPTEATAVGAVEASFKCCSGAIIVLTKSGRSAHQVARYRPRAPIIAVTRNPQTARQAHLYRGIFPVLCKDPVQEAWAEDVDLRVNFAMNVGKARGFFKKGDVVIVLTGWRPGSGFTNTMRVVPV 530

[Close]

BLAST of Pyruvate kinase vs. UniProt/SwissProt
Match: sp|Q5NVN0|KPYM_PONAB (Pyruvate kinase PKM OS=Pongo abelii OX=9601 GN=PKM PE=2 SV=3)

HSP 1 Score: 639.417 bits (1648), Expect = 0.000e+0
Identity = 315/523 (60.23%), Postives = 395/523 (75.53%), Query Frame = 1

Query:  187 QSNYFFQERRRVHKDYA-TNLELVADLNIDSDPGVIRNTGIICTLGPACASVAILHKMIAAGMNVARLNFSHGTHEDHARSIKLLREAIATLKP----YRFPIAIALDTKGPEIRTGLINNNETGEVRLKKGNNIKLVVSEEYYRKCDENFIWVDYKSILKLLKVGNRIFIDDGLISLIVEEKDSEFLLCRIENGGMLGSRKGVNLPGVNVDLPAVSEKDKEDLKFAVEQNVDIVFASFIRNAESVNIIRKILGEKGKHILIISKIENQEGMIQFDEILEASDGIMVARGDLGIEIPPEKVICAQKMMIGKCNVAGKSVICATHMLESMITKSRPTRAEISDVANAVIDGSDCVMLSGESAKGRYPVEAVKMMHTICREAEHLFFQSNFFESIKETVNLPTDHTHSTAIAAVEAAQRCNAAVIIVLTTSGTSAKLIAKYRPSCPILTLTRNPITARQAHLWRGLHPILFSDPRKEEWPKDMDLRINFSINYAYQRGFVKALDIIIIVTGSKAGSGSTNTLQVV 1740
            ++   F + +++H   A T LE +  L+IDS P   RNTGIICT+GPA  SV  L +MI +GMNVARLNFSHGTHE HA +IK +R A  +       YR P+A+ALDTKGPEIRTGLI  + T EV LKKG  +K+ +   Y  KCDEN +W+DYK+I K+++VG++I++DDGLISL V++K ++FLL  +ENGG LGS+KGVNLPG  VDLPAVSEKD +DLKF VEQ+VD+VFASFIR A  V+ +RK+LGEKGK+I IISKIEN EG+ +FDEILEASDGIMVARGDLGIEIP EKV  AQKMMIG+CN AGK VICAT MLESMI K RPTRAE S VANAV+DG+DC+MLSGE+AKG YP+EAV+M H I REAE   F    FE +    +  TD   + A+ +VEA+ +C AA +IVLT SG SA  +A+YRP  PI+ +TRNP TARQAHL+RG+ P+L  DP +E W +D+DLR+NF++N    RGF K  D++I++TG + GSG TNT++VV
Sbjct:    7 EAGTAFIQTQQLHAAMADTFLEHMCRLDIDSPPITARNTGIICTIGPASRSVETLKEMIKSGMNVARLNFSHGTHEYHAETIKNVRTATESFASDPILYR-PVAVALDTKGPEIRTGLIKGSGTAEVELKKGATLKITLDNAYMEKCDENILWLDYKNICKVVEVGSKIYVDDGLISLQVKQKGADFLLTEVENGGSLGSKKGVNLPGAAVDLPAVSEKDIQDLKFGVEQDVDMVFASFIRKASDVHEVRKVLGEKGKNIKIISKIENHEGVRRFDEILEASDGIMVARGDLGIEIPAEKVFLAQKMMIGRCNRAGKPVICATQMLESMIKKPRPTRAEGSGVANAVLDGADCIMLSGETAKGDYPLEAVRMQHLIAREAEAAMFHRKLFEELVRASSHSTDLMEAMAMGSVEASYKCLAAALIVLTESGRSAHQVARYRPRAPIIAVTRNPQTARQAHLYRGIFPVLCKDPVQEAWAEDVDLRVNFAMNVGKARGFFKKGDVVIVLTGWRPGSGFTNTMRVV 528

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BLAST of Pyruvate kinase vs. UniProt/SwissProt
Match: sp|P11979|KPYM_FELCA (Pyruvate kinase PKM OS=Felis catus OX=9685 GN=PKM PE=1 SV=2)

HSP 1 Score: 638.262 bits (1645), Expect = 0.000e+0
Identity = 313/517 (60.54%), Postives = 395/517 (76.40%), Query Frame = 1

Query:  202 FQERRRVHKDYA-TNLELVADLNIDSDPGVIRNTGIICTLGPACASVAILHKMIAAGMNVARLNFSHGTHEDHARSIKLLREAIATL--KPYRF-PIAIALDTKGPEIRTGLINNNETGEVRLKKGNNIKLVVSEEYYRKCDENFIWVDYKSILKLLKVGNRIFIDDGLISLIVEEKDSEFLLCRIENGGMLGSRKGVNLPGVNVDLPAVSEKDKEDLKFAVEQNVDIVFASFIRNAESVNIIRKILGEKGKHILIISKIENQEGMIQFDEILEASDGIMVARGDLGIEIPPEKVICAQKMMIGKCNVAGKSVICATHMLESMITKSRPTRAEISDVANAVIDGSDCVMLSGESAKGRYPVEAVKMMHTICREAEHLFFQSNFFESIKETVNLPTDHTHSTAIAAVEAAQRCNAAVIIVLTTSGTSAKLIAKYRPSCPILTLTRNPITARQAHLWRGLHPILFSDPRKEEWPKDMDLRINFSINYAYQRGFVKALDIIIIVTGSKAGSGSTNTLQVV 1740
            F + +++H   A T LE +  L+IDS P   RNTGIICT+GPA  SV IL +MI +GMNVARLNFSHGTHE HA +IK +R A  +    P R+ P+A+ALDTKGPEIRTGLI  + T EV LKKG  +K+ +   Y  KCDEN +W+DYK+I K+++VG+++++DDGLISL+V+EK ++FL+  +ENGG LGS+KGVNLPG  VDLPAVSEKD +DLKF VEQ+VD+VFASFIR A  V+ +RK+LGEKGK+I IISKIEN EG+ +FDEILEASDGIMVARGDLGIEIP EKV  AQKMMIG+CN AGK VICAT MLESMI K RPTRAE SDVANAV+DG+DC+MLSGE+AKG YP+EAV+M H I REAE   F    FE +    +  TD   + A+ +VEA+ +C AA +IVLT SG SA  +A+YRP  PI+ +TRN  TARQAHL+RG+ P++  DP +E W +D+DLR+N ++N    RGF K  D++I++TG + GSG TNT++VV
Sbjct:   12 FIQTQQLHAAMADTFLEHMCRLDIDSPPITARNTGIICTIGPASRSVEILKEMIKSGMNVARLNFSHGTHEYHAETIKNVRAATESFASDPIRYRPVAVALDTKGPEIRTGLIKGSGTAEVELKKGATLKITLDNAYMEKCDENVLWLDYKNICKVVEVGSKVYVDDGLISLLVKEKGADFLVTEVENGGSLGSKKGVNLPGAAVDLPAVSEKDIQDLKFGVEQDVDMVFASFIRKASDVHEVRKVLGEKGKNIKIISKIENHEGVRRFDEILEASDGIMVARGDLGIEIPAEKVFLAQKMMIGRCNRAGKPVICATQMLESMIKKPRPTRAEGSDVANAVLDGADCIMLSGETAKGDYPLEAVRMQHLIAREAEAAMFHRKLFEELVRGSSHSTDLMEAMAMGSVEASYKCLAAALIVLTESGRSAHQVARYRPRAPIIAVTRNHQTARQAHLYRGIFPVVCKDPVQEAWAEDVDLRVNLAMNVGKARGFFKHGDVVIVLTGWRPGSGFTNTMRVV 528

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BLAST of Pyruvate kinase vs. UniProt/SwissProt
Match: sp|P11980|KPYM_RAT (Pyruvate kinase PKM OS=Rattus norvegicus OX=10116 GN=Pkm PE=1 SV=3)

HSP 1 Score: 632.098 bits (1629), Expect = 0.000e+0
Identity = 312/523 (59.66%), Postives = 394/523 (75.33%), Query Frame = 1

Query:  187 QSNYFFQERRRVHKDYA-TNLELVADLNIDSDPGVIRNTGIICTLGPACASVAILHKMIAAGMNVARLNFSHGTHEDHARSIKLLREAIATLKP----YRFPIAIALDTKGPEIRTGLINNNETGEVRLKKGNNIKLVVSEEYYRKCDENFIWVDYKSILKLLKVGNRIFIDDGLISLIVEEKDSEFLLCRIENGGMLGSRKGVNLPGVNVDLPAVSEKDKEDLKFAVEQNVDIVFASFIRNAESVNIIRKILGEKGKHILIISKIENQEGMIQFDEILEASDGIMVARGDLGIEIPPEKVICAQKMMIGKCNVAGKSVICATHMLESMITKSRPTRAEISDVANAVIDGSDCVMLSGESAKGRYPVEAVKMMHTICREAEHLFFQSNFFESIKETVNLPTDHTHSTAIAAVEAAQRCNAAVIIVLTTSGTSAKLIAKYRPSCPILTLTRNPITARQAHLWRGLHPILFSDPRKEEWPKDMDLRINFSINYAYQRGFVKALDIIIIVTGSKAGSGSTNTLQVV 1740
            ++   F + +++H   A T LE +  L+IDS P   RNTGIICT+GPA  SV +L +MI +GMNVARLNFSHGTHE HA +IK +R A  +       YR P+A+ALDTKGPEIRTGLI  + T EV LKKG  +K+ +   Y  KCDEN +W+DYK+I K+++VG++I++DDGLISL V+EK +++L+  +ENGG LGS+KGVNLPG  VDLPAVSEKD +DLKF VEQ+VD+VFASFIR A  V+ +RK+LGEKGK+I IISKIEN EG+ +FDEILEASDGIMVARGDLGIEIP EKV  AQKMMIG+CN AGK VICAT MLESMI K RPTRAE SDVANAV+DG+DC+MLSGE+AKG YP+EAV+M H I REAE   F    FE +    +  TD   + A+ +VEA+ +C AA +IVLT SG SA  +A+YRP  PI+ +TRNP TARQAHL+RG+ P+L  D   + W +D+DLR+N ++N    RGF K  D++I++TG + GSG TNT++VV
Sbjct:    7 EAGTAFIQTQQLHAAMADTFLEHMCRLDIDSAPITARNTGIICTIGPASRSVEMLKEMIKSGMNVARLNFSHGTHEYHAETIKNVRAATESFASDPILYR-PVAVALDTKGPEIRTGLIKGSGTAEVELKKGATLKITLDNAYMEKCDENILWLDYKNICKVVEVGSKIYVDDGLISLQVKEKGADYLVTEVENGGSLGSKKGVNLPGAAVDLPAVSEKDIQDLKFGVEQDVDMVFASFIRKAADVHEVRKVLGEKGKNIKIISKIENHEGVRRFDEILEASDGIMVARGDLGIEIPAEKVFLAQKMMIGRCNRAGKPVICATQMLESMIKKPRPTRAEGSDVANAVLDGADCIMLSGETAKGDYPLEAVRMQHLIAREAEAAVFHRLLFEELARASSQSTDPLEAMAMGSVEASYKCLAAALIVLTESGRSAHQVARYRPRAPIIAVTRNPQTARQAHLYRGIFPVLCKDAVLDAWAEDVDLRVNLAMNVGKARGFFKKGDVVIVLTGWRPGSGFTNTMRVV 528

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BLAST of Pyruvate kinase vs. UniProt/SwissProt
Match: sp|P11974|KPYM_RABIT (Pyruvate kinase PKM OS=Oryctolagus cuniculus OX=9986 GN=PKM PE=1 SV=4)

HSP 1 Score: 631.713 bits (1628), Expect = 0.000e+0
Identity = 310/528 (58.71%), Postives = 395/528 (74.81%), Query Frame = 1

Query:  172 ARYFEQSNYFFQERRRVHKDYA-TNLELVADLNIDSDPGVIRNTGIICTLGPACASVAILHKMIAAGMNVARLNFSHGTHEDHARSIKLLREAIATLKP----YRFPIAIALDTKGPEIRTGLINNNETGEVRLKKGNNIKLVVSEEYYRKCDENFIWVDYKSILKLLKVGNRIFIDDGLISLIVEEKDSEFLLCRIENGGMLGSRKGVNLPGVNVDLPAVSEKDKEDLKFAVEQNVDIVFASFIRNAESVNIIRKILGEKGKHILIISKIENQEGMIQFDEILEASDGIMVARGDLGIEIPPEKVICAQKMMIGKCNVAGKSVICATHMLESMITKSRPTRAEISDVANAVIDGSDCVMLSGESAKGRYPVEAVKMMHTICREAEHLFFQSNFFESIKETVNLPTDHTHSTAIAAVEAAQRCNAAVIIVLTTSGTSAKLIAKYRPSCPILTLTRNPITARQAHLWRGLHPILFSDPRKEEWPKDMDLRINFSINYAYQRGFVKALDIIIIVTGSKAGSGSTNTLQVV 1740
            ++   ++   F + +++H   A T LE +  L+IDS P   RNTGIICT+GPA  SV  L +MI +GMNVAR+NFSHGTHE HA +IK +R A  +       YR P+A+ALDTKGPEIRTGLI  + T EV LKKG  +K+ +   Y  KCDEN +W+DYK+I K++ VG+++++DDGLISL V++K  +FL+  +ENGG LGS+KGVNLPG  VDLPAVSEKD +DLKF VEQ+VD+VFASFIR A  V+ +RKILGEKGK+I IISKIEN EG+ +FDEILEASDGIMVARGDLGIEIP EKV  AQKM+IG+CN AGK VICAT MLESMI K RPTRAE SDVANAV+DG+DC+MLSGE+AKG YP+EAV+M H I REAE   F    FE +  + +  TD   + A+ +VEA+ +C AA +IVLT SG SA  +A+YRP  PI+ +TRN  TARQAHL+RG+ P++  DP +E W +D+DLR+N ++N    RGF K  D++I++TG + GSG TNT++VV
Sbjct:    2 SKSHSEAGSAFIQTQQLHAAMADTFLEHMCRLDIDSAPITARNTGIICTIGPASRSVETLKEMIKSGMNVARMNFSHGTHEYHAETIKNVRTATESFASDPILYR-PVAVALDTKGPEIRTGLIKGSGTAEVELKKGATLKITLDNAYMEKCDENILWLDYKNICKVVDVGSKVYVDDGLISLQVKQKGPDFLVTEVENGGFLGSKKGVNLPGAAVDLPAVSEKDIQDLKFGVEQDVDMVFASFIRKAADVHEVRKILGEKGKNIKIISKIENHEGVRRFDEILEASDGIMVARGDLGIEIPAEKVFLAQKMIIGRCNRAGKPVICATQMLESMIKKPRPTRAEGSDVANAVLDGADCIMLSGETAKGDYPLEAVRMQHLIAREAEAAMFHRKLFEELARSSSHSTDLMEAMAMGSVEASYKCLAAALIVLTESGRSAHQVARYRPRAPIIAVTRNHQTARQAHLYRGIFPVVCKDPVQEAWAEDVDLRVNLAMNVGKARGFFKKGDVVIVLTGWRPGSGFTNTMRVV 528

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BLAST of Pyruvate kinase vs. TrEMBL
Match: A0A267F274 (Pyruvate kinase OS=Macrostomum lignano OX=282301 GN=BOX15_Mlig009984g1 PE=3 SV=1)

HSP 1 Score: 692.575 bits (1786), Expect = 0.000e+0
Identity = 332/541 (61.37%), Postives = 415/541 (76.71%), Query Frame = 1

Query:  196 YFFQERRRVHKDYATNLELVADLNIDSDPGVIRNTGIICTLGPACASVAILHKMIAAGMNVARLNFSHGTHEDHARSIKLLREAIATLKPYRFPIAIALDTKGPEIRTGLINNNETGEVRLKKGNNIKLVVSEEYYRKCDENFIWVDYKSILKLLKVGNRIFIDDGLISLIVEEKDSEFLLCRIENGGMLGSRKGVNLPGVNVDLPAVSEKDKEDLKFAVEQNVDIVFASFIRNAESVNIIRKILGEKGKHILIISKIENQEGMIQFDEILEASDGIMVARGDLGIEIPPEKVICAQKMMIGKCNVAGKSVICATHMLESMITKSRPTRAEISDVANAVIDGSDCVMLSGESAKGRYPVEAVKMMHTICREAEHLFFQSNFFESIKETVNLPTDHTHSTAIAAVEAAQRCNAAVIIVLTTSGTSAKLIAKYRPSCPILTLTRNPITARQAHLWRGLHPILFSDPRKEEWPKDMDLRINFSINYAYQRGFVKALDIIIIVTGSKAGSGSTNTLQVVKLEIDEKEEIGLKKYISYPTIKEFDD 1818
            YF Q+++    +  ++LE +  L+ID DP  +RNTGIICT+GPAC SVA+LHKMIAAGMN+AR+NFSHGTHE H  +++L+R+A  T K +  P+AIALDTKGPEIRTGLI  + T EV LK+G+ I +     +   C  + +WVDY +I+K+++ G R+F+DDGLISL+V+E     LLC +ENGG LGS+KGVNLPG  VDLPAVSEKDK DL+FAVE  +DIVFASFIRNAE++  I+ ILGE+GK+I II+KIEN EG+ +FDEI+EA+DGIMVARGDLGIEIPPEKV  AQKMMIG+CN AGK VICAT MLESMITK RPTRAEISDVANAV+DG+DCVMLSGE+AKG YP+EAVK MH +CREAE   F S  FE +K  +  PTD TH+TAIAA EAA RC AA IIV+TT+G SA LI+++RP CPILT++R   T RQAHL+RGLHP+ +  PR E+W +DMD RI+F+I+Y  +R F+   D ++IVTG KAG+G TNTL++V++      E     YI  P I  F D
Sbjct:   15 YFIQKQQLQASNARSHLEHLCRLDIDLDPAYVRNTGIICTIGPACKSVAVLHKMIAAGMNIARMNFSHGTHEYHKETVELVRQAADTFKGWSRPVAIALDTKGPEIRTGLIGGSGTAEVELKRGSEIVVTTDPAHSENCSADMLWVDYPNIVKVVREGGRVFVDDGLISLLVKEVRDNSLLCEVENGGNLGSKKGVNLPGAPVDLPAVSEKDKSDLRFAVEMGLDIVFASFIRNAEAIREIKHILGEEGKNIKIIAKIENHEGVRRFDEIMEAADGIMVARGDLGIEIPPEKVFLAQKMMIGRCNRAGKPVICATQMLESMITKPRPTRAEISDVANAVLDGADCVMLSGETAKGSYPLEAVKTMHQVCREAESAMFSSQLFEDLKAELLEPTDITHTTAIAASEAANRCRAAAIIVITTTGRSASLISRHRPRCPILTVSRLAQTCRQAHLFRGLHPLFYDAPRCEQWTEDMDKRIDFAIDYGRKREFINVGDFVVIVTGWKAGAGFTNTLRIVQV-----TEQAASSYIGAPNIVSFFD 550

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BLAST of Pyruvate kinase vs. TrEMBL
Match: A0A267EYV5 (Pyruvate kinase (Fragment) OS=Macrostomum lignano OX=282301 GN=BOX15_Mlig019710g1 PE=3 SV=1)

HSP 1 Score: 686.411 bits (1770), Expect = 0.000e+0
Identity = 321/522 (61.49%), Postives = 411/522 (78.74%), Query Frame = 1

Query:  190 SNYFFQERRRVHKDYATNLELVADLNIDSDPGVIRNTGIICTLGPACASVAILHKMIAAGMNVARLNFSHGTHEDHARSIKLLREAIATLKPYRFPIAIALDTKGPEIRTGLINNNETGEVRLKKGNNIKLVVSEEYYRKCDENFIWVDYKSILKLLKVGNRIFIDDGLISLIVEEKDSEFLLCRIENGGMLGSRKGVNLPGVNVDLPAVSEKDKEDLKFAVEQNVDIVFASFIRNAESVNIIRKILGEKGKHILIISKIENQEGMIQFDEILEASDGIMVARGDLGIEIPPEKVICAQKMMIGKCNVAGKSVICATHMLESMITKSRPTRAEISDVANAVIDGSDCVMLSGESAKGRYPVEAVKMMHTICREAEHLFFQSNFFESIKETVNLPTDHTHSTAIAAVEAAQRCNAAVIIVLTTSGTSAKLIAKYRPSCPILTLTRNPITARQAHLWRGLHPILFSDPRKEEWPKDMDLRINFSINYAYQRGFVKALDIIIIVTGSKAGSGSTNTLQVVKLEID 1755
            + YF Q+++    +  ++LE +  L++DS+P  +RNTGIICT+GPAC SVAILHKMIA GMN+AR+NFSHGTHE H ++++L+R+A  T KP+  P+ IALDTKGPEIRTGLI  + T EV L +G  I + +   +   C ++ +WVDY +I+K++  G R+FIDDGLISL+V+E   + LLC +ENGG LGS+KGVNLPG  VDLPAVSEKD+EDLKFAV+  +D+VFASFIRNA+++  IR ILGE GK+I II+KIEN EG+ +FDEI+EA+DGIMVARGDLGIEIPPEKV  AQKMMIG+CN AGK VICAT MLESMI+K RPTRAEISDVANAV+DG+DCVMLSGE+AKG +P+EAV+ MH +CREAE   + S  FE +K  +  PTD TH+TAIAA EAA RC AA IIV+TT+G SA+L+A++RP CPILT++R   T RQAHLWRGLHP+ F + R ++W +DMD RI F+I Y  QRGF+   D +++VTG KAG+G TNTL+V+++  D
Sbjct:   21 NQYFIQKQQLQASNARSHLEHLCHLDVDSEPAYVRNTGIICTIGPACKSVAILHKMIANGMNIARMNFSHGTHEYHRQTVELVRQAAETFKPWSRPVGIALDTKGPEIRTGLIGGSGTAEVELVRGEPITVTIDSAFAENCSKDTLWVDYPNIVKVINEGGRVFIDDGLISLLVKEIRDKSLLCEVENGGKLGSKKGVNLPGSPVDLPAVSEKDREDLKFAVDLGLDMVFASFIRNADAIREIRHILGEAGKNIKIIAKIENHEGVRRFDEIMEAADGIMVARGDLGIEIPPEKVFLAQKMMIGRCNRAGKPVICATQMLESMISKPRPTRAEISDVANAVLDGADCVMLSGETAKGDFPLEAVRTMHQVCREAESAMYTSQLFEDLKAELLEPTDITHTTAIAASEAANRCRAAAIIVITTTGRSAQLVARHRPRCPILTVSRLAQTCRQAHLWRGLHPLFFDETRSDQWTEDMDKRIEFAIAYGRQRGFINRGDFVVMVTGWKAGTGFTNTLRVIQVTED 542

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BLAST of Pyruvate kinase vs. TrEMBL
Match: A0A430Q112 (Pyruvate kinase OS=Schistosoma bovis OX=6184 GN=DC041_0005495 PE=3 SV=1)

HSP 1 Score: 678.707 bits (1750), Expect = 0.000e+0
Identity = 325/525 (61.90%), Postives = 409/525 (77.90%), Query Frame = 1

Query:  244 LELVADLNIDSDPGVIRNTGIICTLGPACASVAILHKMIAAGMNVARLNFSHGTHEDHARSIKLLREAIATLKPYRFPIAIALDTKGPEIRTGLINNNETGEVRLKKGNNIKLVVSEEYYRKCDENFIWVDYKSILKLLKVGNRIFIDDGLISLIVEEKDSEFLLCRIENGGMLGSRKGVNLPGVNVDLPAVSEKDKEDLKFAVEQNVDIVFASFIRNAESVNIIRKILGEKGKHILIISKIENQEGMIQFDEILEASDGIMVARGDLGIEIPPEKVICAQKMMIGKCNVAGKSVICATHMLESMITKSRPTRAEISDVANAVIDGSDCVMLSGESAKGRYPVEAVKMMHTICREAEHLFFQSNFFESIKETVNLPTDHTHSTAIAAVEAAQRCNAAVIIVLTTSGTSAKLIAKYRPSCPILTLTRNPITARQAHLWRGLHPILFSDPRKEEWPKDMDLRINFSINYAYQRGFVKALDIIIIVTGSKAGSGSTNTLQVVKLEIDEKEEIGLKKYISYPTIKEFDD 1818
            LE V  L+ID  P  +RNTGIICT+GPAC +V IL  M+ +GMN+ARLNFSHG+HE HA++I+L+REA ATLKP+  PI IALDTKGPEIRTGLIN + T EV L+ G+ I++     Y   C+E+ ++VDY++I+ +L  G++IF+DDGLISL+V +K  ++L C +ENGG LGSRKGVNLPG +VDL AVSEKDK+DL+FAVE NVD+VFASFIRNA++V+ IR++LG+ G HI II+KIEN EG+ +F+EIL+A+DGIMVARGDLGIEIP EKV  AQKMMIG+CN  GK VICAT MLESM TK RPTRAE SDVANAV+DG+DCVMLSGE+AKG YP+EAV+ MH IC +AE   F    FE +K ++  PT+  H+TAIAAVEAA RCNAA IIV+TTSG S +LI+++RP CPILT+TR+   ARQ HL+RG+HP+ + +PR  EW +DMD RI ++I+Y  +R F      +IIVTG KAGSGSTNTL+VVKLE  E + I     +  P+I  FDD
Sbjct:   45 LEHVVSLDIDHQPAYVRNTGIICTIGPACRTVEILQNMMTSGMNIARLNFSHGSHEYHAKTIELVREAAATLKPFPRPIGIALDTKGPEIRTGLINGSGTAEVNLQVGHKIRVTTDCAYMEACNESILYVDYRNIVHVLSKGSKIFVDDGLISLVVLDKGPDYLECEVENGGKLGSRKGVNLPGAHVDLDAVSEKDKQDLRFAVEHNVDMVFASFIRNADAVHQIRQLLGDNGSHIKIIAKIENHEGVQRFNEILDAADGIMVARGDLGIEIPAEKVFIAQKMMIGRCNQVGKPVICATQMLESMTTKPRPTRAESSDVANAVLDGADCVMLSGETAKGLYPLEAVQTMHRICVQAEAAMFHGQLFEDLKSSLYGPTEMAHTTAIAAVEAASRCNAAAIIVITTSGRSCQLISRHRPRCPILTVTRHEYIARQIHLYRGVHPLYYGEPRAGEWYEDMDRRIRYAIDYGRKRSFFSPGCFVIIVTGWKAGSGSTNTLRVVKLEDAETKPI-----VMVPSITHFDD 564

[Close]

BLAST of Pyruvate kinase vs. TrEMBL
Match: A0A095B084 (Pyruvate kinase OS=Schistosoma haematobium OX=6185 GN=MS3_08937 PE=3 SV=1)

HSP 1 Score: 677.552 bits (1747), Expect = 0.000e+0
Identity = 324/525 (61.71%), Postives = 409/525 (77.90%), Query Frame = 1

Query:  244 LELVADLNIDSDPGVIRNTGIICTLGPACASVAILHKMIAAGMNVARLNFSHGTHEDHARSIKLLREAIATLKPYRFPIAIALDTKGPEIRTGLINNNETGEVRLKKGNNIKLVVSEEYYRKCDENFIWVDYKSILKLLKVGNRIFIDDGLISLIVEEKDSEFLLCRIENGGMLGSRKGVNLPGVNVDLPAVSEKDKEDLKFAVEQNVDIVFASFIRNAESVNIIRKILGEKGKHILIISKIENQEGMIQFDEILEASDGIMVARGDLGIEIPPEKVICAQKMMIGKCNVAGKSVICATHMLESMITKSRPTRAEISDVANAVIDGSDCVMLSGESAKGRYPVEAVKMMHTICREAEHLFFQSNFFESIKETVNLPTDHTHSTAIAAVEAAQRCNAAVIIVLTTSGTSAKLIAKYRPSCPILTLTRNPITARQAHLWRGLHPILFSDPRKEEWPKDMDLRINFSINYAYQRGFVKALDIIIIVTGSKAGSGSTNTLQVVKLEIDEKEEIGLKKYISYPTIKEFDD 1818
            LE V  L+ID  P  +RNTGIICT+GPAC +V IL  M+ +GMN+ARLNFSHG+HE HA++I+L+REA ATLKP+  PI IALDTKGPEIRTGLIN + T EV L+ G+ I++     Y   C+E+ +++DY++I+ +L  G++IF+DDGLISL+V +K  ++L C +ENGG LGSRKGVNLPG +VDL AVSEKDK+DL+FAVE NVD+VFASFIRNA++V+ IR++LG+ G HI II+KIEN EG+ +F+EIL+A+DGIMVARGDLGIEIP EKV  AQKMMIG+CN  GK VICAT MLESM TK RPTRAE SDVANAV+DG+DCVMLSGE+AKG YP+EAV+ MH IC +AE   F    FE +K ++  PT+  H+TAIAAVEAA RCNAA IIV+TTSG S +LI+++RP CPILT+TR+   ARQ HL+RG+HP+ + +PR  EW +DMD RI ++I+Y  +R F      +IIVTG KAGSGSTNTL+VVKLE  E + I     +  P+I  FDD
Sbjct:   45 LEHVVSLDIDHQPAYVRNTGIICTIGPACRTVEILQNMMTSGMNIARLNFSHGSHEYHAKTIELVREAAATLKPFPRPIGIALDTKGPEIRTGLINGSGTAEVTLQVGHKIRVTTDCAYMEACNESILYMDYRNIVHVLSKGSKIFVDDGLISLVVLDKGPDYLECEVENGGKLGSRKGVNLPGAHVDLDAVSEKDKQDLRFAVEHNVDMVFASFIRNADAVHQIRQLLGDNGSHIKIIAKIENHEGVQRFNEILDAADGIMVARGDLGIEIPAEKVFIAQKMMIGRCNQVGKPVICATQMLESMTTKPRPTRAESSDVANAVLDGADCVMLSGETAKGLYPLEAVQTMHRICVQAEAAMFHGQLFEDLKSSLYGPTEMAHTTAIAAVEAASRCNAAAIIVITTSGRSCQLISRHRPRCPILTVTRHEYIARQIHLYRGVHPLYYGEPRAGEWYEDMDRRIRYAIDYGRKRSFFSPGCFVIIVTGWKAGSGSTNTLRVVKLEDAETKPI-----VMVPSITHFDD 564

[Close]

BLAST of Pyruvate kinase vs. TrEMBL
Match: A0A3Q0KH21 (Pyruvate kinase OS=Schistosoma mansoni OX=6183 PE=3 SV=1)

HSP 1 Score: 675.626 bits (1742), Expect = 0.000e+0
Identity = 327/549 (59.56%), Postives = 417/549 (75.96%), Query Frame = 1

Query:  172 ARYFEQSNYFFQERRRVHKDYATNLELVADLNIDSDPGVIRNTGIICTLGPACASVAILHKMIAAGMNVARLNFSHGTHEDHARSIKLLREAIATLKPYRFPIAIALDTKGPEIRTGLINNNETGEVRLKKGNNIKLVVSEEYYRKCDENFIWVDYKSILKLLKVGNRIFIDDGLISLIVEEKDSEFLLCRIENGGMLGSRKGVNLPGVNVDLPAVSEKDKEDLKFAVEQNVDIVFASFIRNAESVNIIRKILGEKGKHILIISKIENQEGMIQFDEILEASDGIMVARGDLGIEIPPEKVICAQKMMIGKCNVAGKSVICATHMLESMITKSRPTRAEISDVANAVIDGSDCVMLSGESAKGRYPVEAVKMMHTICREAEHLFFQSNFFESIKETVNLPTDHTHSTAIAAVEAAQRCNAAVIIVLTTSGTSAKLIAKYRPSCPILTLTRNPITARQAHLWRGLHPILFSDPRKEEWPKDMDLRINFSINYAYQRGFVKALDIIIIVTGSKAGSGSTNTLQVVKLEIDEKEEIGLKKYISYPTIKEFDD 1818
            +R+ E+S Y       V+    + LE V  L+ID  P  +RNTGIICT+GPAC +V +L  MI +GMN+ARLNFSHG+HE HA +IKL+REA +TLKP+  PI IALDTKGPEIRTGLIN + T EV L+ G+ I++     Y  KC+E+ ++VDY++I+ +L  G++IF+DDGL+SL+V +K  ++L C +ENGG LGSRKGVNLPG +VDLPAVSEKDK+DL+FAVE NVD+VFASFIRNA++V+ IR++LG+ G +I II+KIEN EG+ +F+EIL+  DGIMVARGDLGIEIP EKV  AQKMMIG+CN  GK VICAT MLESM TK RPTRAE SDVANAV+DG+DCVMLSGE+AKG YP+E V+ MH IC +AE   F    FE +K ++  PT+  H+TAIAAVEAA RCNAA IIV+TTSG S +LI+++RP CPILT+TR+ + ARQ HL+RG+HPI + + R  EW +DMD RI ++++Y  +R F      +IIVTG KAGSGSTNTL+VVKLE  E + I     +  P+I  FDD
Sbjct:   20 SRFGEESPYHQNPPLSVYPR--SLLEHVVSLDIDHQPAYVRNTGIICTIGPACRTVEMLQNMITSGMNIARLNFSHGSHEYHAETIKLIREAASTLKPFPRPIGIALDTKGPEIRTGLINGSGTAEVSLEVGHKIRVTTDSAYMEKCNESILYVDYRNIVHVLSKGSKIFVDDGLLSLVVLDKGPDYLECEVENGGKLGSRKGVNLPGAHVDLPAVSEKDKQDLRFAVEHNVDMVFASFIRNADAVHQIRQLLGDNGAYIKIIAKIENHEGVQRFNEILDVVDGIMVARGDLGIEIPAEKVFIAQKMMIGRCNQVGKPVICATQMLESMTTKPRPTRAESSDVANAVLDGADCVMLSGETAKGLYPLETVQTMHRICIQAEAAMFHGQLFEDLKSSLYGPTEMAHTTAIAAVEAASRCNAAAIIVITTSGRSCQLISRHRPRCPILTVTRHEVIARQIHLYRGVHPIYYGESRAGEWYEDMDRRIRYALDYGKKRSFFSPGCFVIIVTGWKAGSGSTNTLRVVKLEDAETKPI-----VMVPSITHFDD 561

[Close]

BLAST of Pyruvate kinase vs. Ensembl Cavefish
Match: pkma (pyruvate kinase PKM [Source:NCBI gene;Acc:103044212])

HSP 1 Score: 630.943 bits (1626), Expect = 0.000e+0
Identity = 302/505 (59.80%), Postives = 388/505 (76.83%), Query Frame = 1

Query:  238 TNLELVADLNIDSDPGVIRNTGIICTLGPACASVAILHKMIAAGMNVARLNFSHGTHEDHARSIKLLREAIATLKP----YRFPIAIALDTKGPEIRTGLINNNETGEVRLKKGNNIKLVVSEEYYRKCDENFIWVDYKSILKLLKVGNRIFIDDGLISLIVEEKDSEFLLCRIENGGMLGSRKGVNLPGVNVDLPAVSEKDKEDLKFAVEQNVDIVFASFIRNAESVNIIRKILGEKGKHILIISKIENQEGMIQFDEILEASDGIMVARGDLGIEIPPEKVICAQKMMIGKCNVAGKSVICATHMLESMITKSRPTRAEISDVANAVIDGSDCVMLSGESAKGRYPVEAVKMMHTICREAEHLFFQSNFFESIKETVNLPTDHTHSTAIAAVEAAQRCNAAVIIVLTTSGTSAKLIAKYRPSCPILTLTRNPITARQAHLWRGLHPILFSDPRKEEWPKDMDLRINFSINYAYQRGFVKALDIIIIVTGSKAGSGSTNTLQVV 1740
            T LE +  L+IDS+P   RNTGIICT+GPA  SV +L +MI +GMN+ARLNFSHG+HE H  +IK +REA  + +P    YR PI IALDTKGPEIRTGLI  + T EV LKKGN IK+ + + Y   CDE+ +W+DYK+I K++++G++++IDDGLISL V+E  S+++LC IENGG LGS+KGVNLPG  VDLPAVSEKD +DL+F VE  VD+VFASFIR A+ VN +R++LGEKGK+I IISK+EN EG+ +FDEI+EASDGIMVARGDLGIEIP EKV  AQKMMIG+CN AGK + CAT MLESMI K RPTRAE SDVANAV+DG+DC+MLSGE+AKG YP+EAV+  H I REAE   F    FE ++    +  D + + AI AVE++ +C A+ IIVLT SG SA LI++YRP  PI+ +TRN  TARQAHL+RG+ P+ ++ P  + W +D+DLR+NF+++    RGF K  D++I++TG + GSG TNT++VV
Sbjct:  124 TFLEHMCLLDIDSEPTTARNTGIICTIGPASRSVDMLKEMIKSGMNIARLNFSHGSHEYHGETIKNIREATESFEPGSIHYR-PIGIALDTKGPEIRTGLIKGSGTAEVELKKGNTIKVTLDDAYMENCDEDVLWLDYKNITKVVEIGSKVYIDDGLISLQVQEIGSDYILCEIENGGTLGSKKGVNLPGAAVDLPAVSEKDIKDLQFGVEMGVDMVFASFIRKAQDVNEVRQVLGEKGKNIKIISKLENHEGVRRFDEIMEASDGIMVARGDLGIEIPTEKVFLAQKMMIGRCNRAGKPITCATQMLESMIKKPRPTRAEGSDVANAVLDGADCIMLSGETAKGDYPLEAVRTQHMIAREAEAAMFHRQLFEELRRANKMTHDPSEAVAIGAVESSFKCCASAIIVLTKSGRSAHLISRYRPRAPIIAVTRNGQTARQAHLYRGIFPVFYNKPAHDVWAEDVDLRVNFAMDVGKARGFFKTGDVVIVLTGWRPGSGFTNTMRVV 627

[Close]

BLAST of Pyruvate kinase vs. Ensembl Cavefish
Match: pkma (pyruvate kinase PKM [Source:NCBI gene;Acc:103044212])

HSP 1 Score: 630.943 bits (1626), Expect = 0.000e+0
Identity = 302/507 (59.57%), Postives = 389/507 (76.73%), Query Frame = 1

Query:  238 TNLELVADLNIDSDPGVIRNTGIICTLGPACASVAILHKMIAAGMNVARLNFSHGTHEDHARSIKLLREAIATLKP----YRFPIAIALDTKGPEIRTGLINNNETGEVRLKKGNNIKLVVSEEYYRKCDENFIWVDYKSILKLLKVGNRIFIDDGLISLIVEEKDSEFLLCRIENGGMLGSRKGVNLPGVNVDLPAVSEKDKEDLKFAVEQNVDIVFASFIRNAESVNIIRKILGEKGKHILIISKIENQEGMIQFDEILEASDGIMVARGDLGIEIPPEKVICAQKMMIGKCNVAGKSVICATHMLESMITKSRPTRAEISDVANAVIDGSDCVMLSGESAKGRYPVEAVKMMHTICREAEHLFFQSNFFESIKETVNLPTDHTHSTAIAAVEAAQRCNAAVIIVLTTSGTSAKLIAKYRPSCPILTLTRNPITARQAHLWRGLHPILFSDPRKEEWPKDMDLRINFSINYAYQRGFVKALDIIIIVTGSKAGSGSTNTLQVVKL 1746
            T LE +  L+IDS+P   RNTGIICT+GPA  SV +L +MI +GMN+ARLNFSHG+HE H  +IK +REA  + +P    YR PI IALDTKGPEIRTGLI  + T EV LKKGN IK+ + + Y   CDE+ +W+DYK+I K++++G++++IDDGLISL V+E  S+++LC IENGG LGS+KGVNLPG  VDLPAVSEKD +DL+F VE  VD+VFASFIR A+ VN +R++LGEKGK+I IISK+EN EG+ +FDEI+EASDGIMVARGDLGIEIP EKV  AQKMMIG+CN AGK + CAT MLESMI K RPTRAE SDVANAV+DG+DC+MLSGE+AKG YP+EAV+  H I REAE   F    FE ++    +  D + + AI AVE++ +C A+ IIVLT SG SA LI++YRP  PI+ +TRN  TARQAHL+RG+ P+ ++ P  + W +D+DLR+NF+++    RGF K  D++I++TG + GSG TNT++VV +
Sbjct:   49 TFLEHMCLLDIDSEPTTARNTGIICTIGPASRSVDMLKEMIKSGMNIARLNFSHGSHEYHGETIKNIREATESFEPGSIHYR-PIGIALDTKGPEIRTGLIKGSGTAEVELKKGNTIKVTLDDAYMENCDEDVLWLDYKNITKVVEIGSKVYIDDGLISLQVQEIGSDYILCEIENGGTLGSKKGVNLPGAAVDLPAVSEKDIKDLQFGVEMGVDMVFASFIRKAQDVNEVRQVLGEKGKNIKIISKLENHEGVRRFDEIMEASDGIMVARGDLGIEIPTEKVFLAQKMMIGRCNRAGKPITCATQMLESMIKKPRPTRAEGSDVANAVLDGADCIMLSGETAKGDYPLEAVRTQHMIAREAEAAMFHRQLFEELRRANKMTHDPSEAVAIGAVESSFKCCASAIIVLTKSGRSAHLISRYRPRAPIIAVTRNGQTARQAHLYRGIFPVFYNKPAHDVWAEDVDLRVNFAMDVGKARGFFKTGDVVIVLTGWRPGSGFTNTMRVVPV 554

[Close]

BLAST of Pyruvate kinase vs. Ensembl Cavefish
Match: pkma (pyruvate kinase PKM [Source:NCBI gene;Acc:103044212])

HSP 1 Score: 630.558 bits (1625), Expect = 0.000e+0
Identity = 302/507 (59.57%), Postives = 389/507 (76.73%), Query Frame = 1

Query:  238 TNLELVADLNIDSDPGVIRNTGIICTLGPACASVAILHKMIAAGMNVARLNFSHGTHEDHARSIKLLREAIATLKP----YRFPIAIALDTKGPEIRTGLINNNETGEVRLKKGNNIKLVVSEEYYRKCDENFIWVDYKSILKLLKVGNRIFIDDGLISLIVEEKDSEFLLCRIENGGMLGSRKGVNLPGVNVDLPAVSEKDKEDLKFAVEQNVDIVFASFIRNAESVNIIRKILGEKGKHILIISKIENQEGMIQFDEILEASDGIMVARGDLGIEIPPEKVICAQKMMIGKCNVAGKSVICATHMLESMITKSRPTRAEISDVANAVIDGSDCVMLSGESAKGRYPVEAVKMMHTICREAEHLFFQSNFFESIKETVNLPTDHTHSTAIAAVEAAQRCNAAVIIVLTTSGTSAKLIAKYRPSCPILTLTRNPITARQAHLWRGLHPILFSDPRKEEWPKDMDLRINFSINYAYQRGFVKALDIIIIVTGSKAGSGSTNTLQVVKL 1746
            T LE +  L+IDS+P   RNTGIICT+GPA  SV +L +MI +GMN+ARLNFSHG+HE H  +IK +REA  + +P    YR PI IALDTKGPEIRTGLI  + T EV LKKGN IK+ + + Y   CDE+ +W+DYK+I K++++G++++IDDGLISL V+E  S+++LC IENGG LGS+KGVNLPG  VDLPAVSEKD +DL+F VE  VD+VFASFIR A+ VN +R++LGEKGK+I IISK+EN EG+ +FDEI+EASDGIMVARGDLGIEIP EKV  AQKMMIG+CN AGK + CAT MLESMI K RPTRAE SDVANAV+DG+DC+MLSGE+AKG YP+EAV+  H I REAE   F    FE ++    +  D + + AI AVE++ +C A+ IIVLT SG SA LI++YRP  PI+ +TRN  TARQAHL+RG+ P+ ++ P  + W +D+DLR+NF+++    RGF K  D++I++TG + GSG TNT++VV +
Sbjct:   79 TFLEHMCLLDIDSEPTTARNTGIICTIGPASRSVDMLKEMIKSGMNIARLNFSHGSHEYHGETIKNIREATESFEPGSIHYR-PIGIALDTKGPEIRTGLIKGSGTAEVELKKGNTIKVTLDDAYMENCDEDVLWLDYKNITKVVEIGSKVYIDDGLISLQVQEIGSDYILCEIENGGTLGSKKGVNLPGAAVDLPAVSEKDIKDLQFGVEMGVDMVFASFIRKAQDVNEVRQVLGEKGKNIKIISKLENHEGVRRFDEIMEASDGIMVARGDLGIEIPTEKVFLAQKMMIGRCNRAGKPITCATQMLESMIKKPRPTRAEGSDVANAVLDGADCIMLSGETAKGDYPLEAVRTQHMIAREAEAAMFHRQLFEELRRANKMTHDPSEAVAIGAVESSFKCCASAIIVLTKSGRSAHLISRYRPRAPIIAVTRNGQTARQAHLYRGIFPVFYNKPAHDVWAEDVDLRVNFAMDVGKARGFFKTGDVVIVLTGWRPGSGFTNTMRVVPV 584

[Close]

BLAST of Pyruvate kinase vs. Ensembl Cavefish
Match: pkma (pyruvate kinase PKM [Source:NCBI gene;Acc:103044212])

HSP 1 Score: 629.787 bits (1623), Expect = 0.000e+0
Identity = 302/507 (59.57%), Postives = 389/507 (76.73%), Query Frame = 1

Query:  238 TNLELVADLNIDSDPGVIRNTGIICTLGPACASVAILHKMIAAGMNVARLNFSHGTHEDHARSIKLLREAIATLKP----YRFPIAIALDTKGPEIRTGLINNNETGEVRLKKGNNIKLVVSEEYYRKCDENFIWVDYKSILKLLKVGNRIFIDDGLISLIVEEKDSEFLLCRIENGGMLGSRKGVNLPGVNVDLPAVSEKDKEDLKFAVEQNVDIVFASFIRNAESVNIIRKILGEKGKHILIISKIENQEGMIQFDEILEASDGIMVARGDLGIEIPPEKVICAQKMMIGKCNVAGKSVICATHMLESMITKSRPTRAEISDVANAVIDGSDCVMLSGESAKGRYPVEAVKMMHTICREAEHLFFQSNFFESIKETVNLPTDHTHSTAIAAVEAAQRCNAAVIIVLTTSGTSAKLIAKYRPSCPILTLTRNPITARQAHLWRGLHPILFSDPRKEEWPKDMDLRINFSINYAYQRGFVKALDIIIIVTGSKAGSGSTNTLQVVKL 1746
            T LE +  L+IDS+P   RNTGIICT+GPA  SV +L +MI +GMN+ARLNFSHG+HE H  +IK +REA  + +P    YR PI IALDTKGPEIRTGLI  + T EV LKKGN IK+ + + Y   CDE+ +W+DYK+I K++++G++++IDDGLISL V+E  S+++LC IENGG LGS+KGVNLPG  VDLPAVSEKD +DL+F VE  VD+VFASFIR A+ VN +R++LGEKGK+I IISK+EN EG+ +FDEI+EASDGIMVARGDLGIEIP EKV  AQKMMIG+CN AGK + CAT MLESMI K RPTRAE SDVANAV+DG+DC+MLSGE+AKG YP+EAV+  H I REAE   F    FE ++    +  D + + AI AVE++ +C A+ IIVLT SG SA LI++YRP  PI+ +TRN  TARQAHL+RG+ P+ ++ P  + W +D+DLR+NF+++    RGF K  D++I++TG + GSG TNT++VV +
Sbjct:   51 TFLEHMCLLDIDSEPTTARNTGIICTIGPASRSVDMLKEMIKSGMNIARLNFSHGSHEYHGETIKNIREATESFEPGSIHYR-PIGIALDTKGPEIRTGLIKGSGTAEVELKKGNTIKVTLDDAYMENCDEDVLWLDYKNITKVVEIGSKVYIDDGLISLQVQEIGSDYILCEIENGGTLGSKKGVNLPGAAVDLPAVSEKDIKDLQFGVEMGVDMVFASFIRKAQDVNEVRQVLGEKGKNIKIISKLENHEGVRRFDEIMEASDGIMVARGDLGIEIPTEKVFLAQKMMIGRCNRAGKPITCATQMLESMIKKPRPTRAEGSDVANAVLDGADCIMLSGETAKGDYPLEAVRTQHMIAREAEAAMFHRQLFEELRRANKMTHDPSEAVAIGAVESSFKCCASAIIVLTKSGRSAHLISRYRPRAPIIAVTRNGQTARQAHLYRGIFPVFYNKPAHDVWAEDVDLRVNFAMDVGKARGFFKTGDVVIVLTGWRPGSGFTNTMRVVPV 556

[Close]

BLAST of Pyruvate kinase vs. Ensembl Cavefish
Match: pkmb (pyruvate kinase PKM-like [Source:NCBI gene;Acc:103047790])

HSP 1 Score: 627.861 bits (1618), Expect = 0.000e+0
Identity = 307/505 (60.79%), Postives = 381/505 (75.45%), Query Frame = 1

Query:  238 TNLELVADLNIDSDPGVIRNTGIICTLGPACASVAILHKMIAAGMNVARLNFSHGTHEDHARSIKLLREAIATLKP----YRFPIAIALDTKGPEIRTGLINNNETGEVRLKKGNNIKLVVSEEYYRKCDENFIWVDYKSILKLLKVGNRIFIDDGLISLIVEEKDSEFLLCRIENGGMLGSRKGVNLPGVNVDLPAVSEKDKEDLKFAVEQNVDIVFASFIRNAESVNIIRKILGEKGKHILIISKIENQEGMIQFDEILEASDGIMVARGDLGIEIPPEKVICAQKMMIGKCNVAGKSVICATHMLESMITKSRPTRAEISDVANAVIDGSDCVMLSGESAKGRYPVEAVKMMHTICREAEHLFFQSNFFESIKETVNLPTDHTHSTAIAAVEAAQRCNAAVIIVLTTSGTSAKLIAKYRPSCPILTLTRNPITARQAHLWRGLHPILFSDPRKEEWPKDMDLRINFSINYAYQRGFVKALDIIIIVTGSKAGSGSTNTLQVV 1740
            T LE +  L+IDS+P V RNTGIICT+GPA  SV  L +MI AGMN+ARLNFSHGTHE HA +IK +REA  +  P    YR P+AIALDTKGPEIRTGLI  + T EV L KG+ IKL + ++Y   CDE  +W+DYK+I K+++ G+ I++DDGLISL V E   ++L C IENGGMLGS+KGVNLPG N+DLPAVSEKD +DL+F VEQ VD+VFASFIR A  V  +RK+LGEKGK I +ISK+EN EG+ +FDEILEASDGIMVARGD+GIEIP EKV  AQKMMI + N  GK + CAT MLESMI K RPTRAE SDVANAV+DG+DC+MLSGE+AKG YPVE+V+  H I REAE   F    FE ++   +L  D   S AI AVEA+ +C A+ IIVLT SG SA L++KYRP  PIL +TRN  TARQ+HL+RG++PIL++ P  + W +D+DLR+NF++     R F K+ D++I+VTG + GSG TNT++VV
Sbjct:   24 TLLEHMCLLDIDSEPAVYRNTGIICTIGPASRSVEKLREMIKAGMNIARLNFSHGTHEYHAETIKNVREATESFGPGTLEYR-PVAIALDTKGPEIRTGLIKGSGTEEVTLNKGDKIKLTLDDKYKDNCDEKTLWLDYKNITKVVQQGSHIYVDDGLISLKVIEVGGDYLTCEIENGGMLGSKKGVNLPGANIDLPAVSEKDTQDLQFGVEQGVDMVFASFIRKAADVQAVRKVLGEKGKEIRVISKLENHEGVRRFDEILEASDGIMVARGDMGIEIPTEKVFLAQKMMISRSNRIGKPITCATQMLESMIKKPRPTRAESSDVANAVLDGADCIMLSGETAKGEYPVESVRTQHQIAREAEAAMFHRQVFEELRRITHLTRDPCESVAIGAVEASFKCCASGIIVLTKSGRSAHLLSKYRPRAPILAVTRNEQTARQSHLYRGIYPILYNKPANDVWAEDVDLRVNFALEMGKFRKFFKSGDVVIVVTGWRPGSGYTNTMRVV 527

[Close]

BLAST of Pyruvate kinase vs. Ensembl Sea Lamprey
Match: pkma (pyruvate kinase M1/2a [Source:ZFIN;Acc:ZDB-GENE-031201-4])

HSP 1 Score: 603.594 bits (1555), Expect = 0.000e+0
Identity = 297/528 (56.25%), Postives = 384/528 (72.73%), Query Frame = 1

Query:  199 FFQERRRVHKDYATNLELVADLNIDSDPGVIRNTGIICTLGPACASVAILHKMIAAGMNVARLNFSHGTHEDHARSIKLLREAIATLKP---YRFPIAIALDTKGPEIRTGLIN-------NNETGEVRLKKGNNIKLVVSEEYYRKCDENFIWVDYKSILKLLKVGNRIFIDDGLISLIVEE--KDSEFLLCRIENGGMLGSRKGVNLPGVNVDLPAVSEKDKEDLKFAVEQNVDIVFASFIRNAESVNIIRKILGEKGKHILIISKIENQEGMIQFDEILEASDGIMVARGDLGIEIPPEKVICAQKMMIGKCNVAGKSVICATHMLESMITKSRPTRAEISDVANAVIDGSDCVMLSGESAKGRYPVEAVKMMHTICREAEHLFFQSNFFESIKETVNLPTDHTHSTAIAAVEAAQRCNAAVIIVLTTSGTSAKLIAKYRPSCPILTLTRNPITARQAHLWRGLHPILFSDPRKEEWPKDMDLRINFSINYAYQRGFVKALDIIIIVTGSKAGSGSTNTLQVVKL 1746
            F Q ++       T LE +  L+IDS+P   RNTGIICT+GPA  S+  L +MI +GMN+AR+NFSHG+HE H+ +IK +REA  +      Y  P+ +ALDTKGPEIRTGLI         + T EV LKKG  +K+ + + Y   CD+  +W+DYK+I K++  G++IF+DDGLISL+V+E  K  ++++  +ENGGMLGSRKGVNLPG  VDLPAVS KD +DL+F V+Q VD+VFASFIR A  V  +R +LGEKGK+I IISKIEN EG+ +F+EILEASDGIMVARGDLGIEIP EKV  AQKMMIG+CN AGK VICAT MLESMI K RPTRAE SDVANAV+DG+DC+MLSGE+AKG YP+EAV+M H I REAE   +    FE ++    + +D T +TAI  VEA+ +C+A  IIVLT SG SA L++KYRP  PI+ +TR   TARQAHL+RG+ P+L  +P  + W +D+DLR+N ++     RGF K  D++I+VTG + GSG TN ++V+K+
Sbjct:   12 FVQTQQLSASRADTFLEHMCLLDIDSEPITARNTGIICTIGPASRSLDTLKEMIKSGMNIARMNFSHGSHEYHSDTIKNVREATESFAGNPIYYRPVGVALDTKGPEIRTGLIKGAVVVAAQSGTAEVELKKGAELKVTLDDAYQDACDDTMVWLDYKNITKVVTPGSKIFVDDGLISLLVKEIGKGDDYVITEVENGGMLGSRKGVNLPGAAVDLPAVSAKDVQDLQFGVDQGVDMVFASFIRKAADVEEVRAVLGEKGKNIKIISKIENHEGVRRFEEILEASDGIMVARGDLGIEIPGEKVFIAQKMMIGRCNRAGKPVICATQMLESMIKKPRPTRAESSDVANAVLDGADCIMLSGETAKGDYPLEAVRMQHAIAREAEAAMYHRQLFEELRRLSGITSDPTETTAIGTVEASFKCSAGAIIVLTKSGRSAHLLSKYRPRAPIIAVTRCGQTARQAHLYRGIFPVLCREPVNDVWAEDVDLRVNLAMEVGKCRGFFKQDDVVIVVTGWRPGSGYTNMMRVIKV 539

[Close]

BLAST of Pyruvate kinase vs. Ensembl Yeast
Match: CDC19 (Pyruvate kinase; functions as a homotetramer in glycolysis to convert phosphoenolpyruvate to pyruvate, the input for aerobic (TCA cycle) or anaerobic (glucose fermentation) respiration; regulated via allosteric activation by fructose bisphosphate; CDC19 has a paralog, PYK2, that arose from the whole genome duplication [Source:SGD;Acc:S000000036])

HSP 1 Score: 447.973 bits (1151), Expect = 8.551e-152
Identity = 239/503 (47.51%), Postives = 328/503 (65.21%), Query Frame = 1

Query:  238 TNLELVADLNI--DSDPGVIRNTGIICTLGPACASVAILHKMIAAGMNVARLNFSHGTHEDHARSIKLLREAIATLKPYRFPIAIALDTKGPEIRTGLINNNETGEVRLKKGNNIKLVVSEEYYRKCDENFIWVDYKSILKLLKVGNRIFIDDGLISL-IVEEKDSEFLLCRIENGGMLGSRKGVNLPGVNVDLPAVSEKDKEDLKFAVEQNVDIVFASFIRNAESVNIIRKILGEKGKHILIISKIENQEGMIQFDEILEASDGIMVARGDLGIEIPPEKVICAQKMMIGKCNVAGKSVICATHMLESMITKSRPTRAEISDVANAVIDGSDCVMLSGESAKGRYPVEAVKMMHTICREAEHLFFQSNFFESIKETVNLPTDHTHSTAIAAVEAAQRCNAAVIIVLTTSGTSAKLIAKYRPSCPILTLTRNPITARQAHLWRGLHPILFSDPRKEEWPKDMDLRINFSINYAYQRGFVKALDIIIIVTGSKAGSGSTNTLQV 1737
            + LE +  LN+   SD   +R T II T+GP   +   L  +  AG+N+ R+NFSHG++E H   I   R++   L P R P+AIALDTKGPEIRTG   N+   +  +   + +     ++Y + CD+  ++VDYK+I K++  G  I++DDG++S  ++E  D + L  +  N G + S KGVNLPG +VDLPA+SEKDKEDL+F V+  V +VFASFIR A  V  IR++LGE+GK + II KIENQ+G+  FDEIL+ +DG+MVARGDLGIEIP  +V+  QK +I K N+AGK VICAT MLESM    RPTRAE+SDV NA++DG+DCVMLSGE+AKG YP+ AV  M      AE        ++ ++     PT  T + A +AV A     A  IIVL+TSGT+ +L++KYRP+CPI+ +TR P  AR +HL+RG+ P +F      +W  D++ RINF I  A + G +K  D  + + G KAG+G +NTLQV
Sbjct:    2 SRLERLTSLNVVAGSD---LRRTSIIGTIGPKTNNPETLVALRKAGLNIVRMNFSHGSYEYHKSVIDNARKS-EELYPGR-PLAIALDTKGPEIRTGTTTNDV--DYPIPPNHEMIFTTDDKYAKACDDKIMYVDYKNITKVISAGRIIYVDDGVLSFQVLEVVDDKTLKVKALNAGKICSHKGVNLPGTDVDLPALSEKDKEDLRFGVKNGVHMVFASFIRTANDVLTIREVLGEQGKDVKIIVKIENQQGVNNFDEILKVTDGVMVARGDLGIEIPAPEVLAVQKKLIAKSNLAGKPVICATQMLESMTYNPRPTRAEVSDVGNAILDGADCVMLSGETAKGNYPINAVTTMAETAVIAEQAIAYLPNYDDMRNCTPKPTSTTETVAASAVAAVFEQKAKAIIVLSTSGTTPRLVSKYRPNCPIILVTRCPRAARFSHLYRGVFPFVFEKEPVSDWTDDVEARINFGIEKAKEFGILKKGDTYVSIQGFKAGAGHSNTLQV 497

[Close]

BLAST of Pyruvate kinase vs. Ensembl Yeast
Match: PYK2 (Pyruvate kinase; appears to be modulated by phosphorylation; transcription repressed by glucose, and Pyk2p may be active under low glycolytic flux; PYK2 has a paralog, CDC19, that arose from the whole genome duplication [Source:SGD;Acc:S000005874])

HSP 1 Score: 411.764 bits (1057), Expect = 1.224e-137
Identity = 222/503 (44.14%), Postives = 321/503 (63.82%), Query Frame = 1

Query:  238 TNLELVADLNIDSDPGVIRNTGIICTLGPACASVAILHKMIAAGMNVARLNFSHGTHEDHARSIKLLREAIATLK--PYRFPIAIALDTKGPEIRTGLINNNETGEVRLKKGNNIKLVVSEEYYRKCDENFIWVDYKSILKLLKVGNRIFIDDGLISL-IVEEKDSEFLLCRIENGGMLGSRKGVNLPGVNVDLPAVSEKDKEDLKFAVEQNVDIVFASFIRNAESVNIIRKILGEKGKHILIISKIENQEGMIQFDEILEASDGIMVARGDLGIEIPPEKVICAQKMMIGKCNVAGKSVICATHMLESMITKSRPTRAEISDVANAVIDGSDCVMLSGESAKGRYPVEAVKMMHTICREAEHLFFQSNFFESIKETVNLPTDHTHSTAIAAVEAAQRCNAAVIIVLTTSGTSAKLIAKYRPSCPILTLTRNPITARQAHLWRGLHPILFSDPRKEEWPKDMDLRINFSINYAYQRGFVKALDIIIIVTGSKAGSGSTNTLQV 1737
            + L+ +A+L I + P  +R T II T+GP   S   +  +  AG+N+ RLNFSHG++E H   I+    A+ + +  P R P+AIALDTKGPEIRTG   N++  ++ +   + +       +    ++  +++DY ++ K++  G  I++DDG++S  +++  D   L  +  N G + S KGVNLP  +VDLP +S KD +DL+F V   + IVFASFIR +E V  IRK LG +G+ I IISKIENQ+G+  FDEILE +DG+M+ARGDLGIEI   +V+  QK +I KCN+AGK VICAT ML+SM    RPTRAE+SDV NAV+DG+DCVMLSGE+AKG YPV AV +M      AE        ++ +++    PT  T + A AA  A    +   I+VL+T+G +A+L++KYRPSCPI+ +TR+  TAR AHL+RG+ P L+   R ++W +D+  R+ F +  A   G V   D ++ + G K G G +NTL++
Sbjct:    4 SRLQRLANLKIGT-PQQLRRTSIIGTIGPKTNSCEAITALRKAGLNIIRLNFSHGSYEFHQSVIE---NAVKSEQQFPGR-PLAIALDTKGPEIRTGRTLNDQ--DLYIPVDHQMIFTTDASFANTSNDKIMYIDYANLTKVIVPGRFIYVDDGILSFKVLQIIDESNLRVQAVNSGYIASHKGVNLPNTDVDLPPLSAKDMKDLQFGVRNGIHIVFASFIRTSEDVLSIRKALGSEGQDIKIISKIENQQGLDNFDEILEVTDGVMIARGDLGIEILAPEVLAIQKKLIAKCNLAGKPVICATQMLDSMTHNPRPTRAEVSDVGNAVLDGADCVMLSGETAKGDYPVNAVNIMAATALIAESTIAHLALYDDLRDATPKPTSTTETVAAAATAAILEQDGKAIVVLSTTGNTARLLSKYRPSCPIILVTRHARTARIAHLYRGVFPFLYEPKRLDDWGEDVHRRLKFGVEMARSFGMVDNGDTVVSIQGFKGGVGHSNTLRI 499

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BLAST of Pyruvate kinase vs. Ensembl Yeast
Match: YAL037C-B_mRNA (Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching [Source:SGD;Acc:S000028592])

HSP 1 Score: 130.954 bits (328), Expect = 4.497e-34
Identity = 85/317 (26.81%), Postives = 161/317 (50.79%), Query Frame = -1

Query:  793 QCVG*ARTGL*TSDNNYYIQCLDKAPLISIIN*EVNS*VHVFWPFFLTWI*K*NWMKTTPKMSLASSNRVSCESKNWT*WSVFGDKFCRSSRCC*NNYHCSIASLSCFYCSYSGTMSVICRQINCFFYTLKEI----RLKK*MFSFTTNCVHHFHSFHWITTFSTFTR*HHAI*PVDDRISYIANFSSCWSRFRNHRFKHMSCTNH*FSCYIAFANHHFLCTDYFFRRYFNSQITSGHHNSVTSLKNFIKLNHSFLVFDL*NYENMLPLFSKNFPNNIYRFRISDK*RKNNINVLFNCKXXXXXXXFRNCW*ININS 1731
            Q VG   TGL T D N  +  L     +S+ N EV++  ++  P    ++ +  W  T+ ++  +SS+  S    +WT WSV G++    +    +N    +     F  S     S         + T+  +    ++   +FS  +   H  +   W+ T   FTR H+ +  + D ++ I NFSS WS   +H F+H+  T++  +  +  +N   L +  F+   FN+Q+TSG+HN+V+ L++F+++ ++ LVF+L N  ++L LF+++F +       SD+  +++++ + + + QIF + FR  W I+I +
Sbjct:   11 QSVGVTSTGLETLDGNVSVTLLQDTEFLSLFNTEVDTGFNIISPVRDRFLFENEWEDTSVQVRESSSSWASGNQDDWTVWSVLGNQSWGGTGSGQDNDSLGL----LFENSSDSGGSDGFGGGGWLWSTVSHVIVVWQVSDSLFSNDSGFSHSGNGVDWVVTLGGFTRQHNTVSTIQDSVTDIGNFSSGWSWVVSHGFQHLGSTDNWLTSQVRLSNQFLLDSQDFWGWDFNTQVTSGNHNTVSDLQDFVEVVNTLLVFNLDNDLDVLTLFTQDFSDGQNIVGGSDERSEDHVDTVLDTESQIFLVLFRQSWQIDIGT 323

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BLAST of Pyruvate kinase vs. Ensembl Nematostella
Match: EDO49963 (Pyruvate kinase [Source:UniProtKB/TrEMBL;Acc:A7RER9])

HSP 1 Score: 521.931 bits (1343), Expect = 1.948e-179
Identity = 263/542 (48.52%), Postives = 369/542 (68.08%), Query Frame = 1

Query:  166 QGARYFEQSNYFFQERRRVHKDYATNLELVADLNIDSDPGVIRNTGIICTLGPACASVAILHKMIAAGMNVARLNFSHGTHEDHARSIKLLREAIATLKPYRFPIAIALDTKGPEIRTGLINNNETGEVRLKKGNNIKLVVSEEYYRKCDENFIWVDYKSILKLLKVGNRIFIDDGLISLIVEEKDSEFLLCRIENGGMLGSRKGVNLPGVNVDLPAVSEKDKEDLKFAVEQNVDIVFASFIRNAESVNIIRKILGEKGKHILIISKIENQEGMIQFDEILEASDGIMVARGDLGIEIPPEKVICAQKMMIGKCNVAGKSVICATHMLESMITKSRPTRAEISDVANAVIDGSDCVMLSGESAKGRYPVEAVKMMHTICREAEHLFFQSNFFESIKETVNLPTDHTHSTAIAAVEAAQRCNAAVIIVLTTSGTSAKLIAKYRPSCPILTLTRNPITARQAHLWRGLHPILFSDPRKEEWPKDMDLRINFSINYAYQRGFVKALDIIIIVTGSKAGSGSTNTLQVVKLEIDEKEEIGLKKYIS 1791
            +GAR     +   + ++ +     +NLE  ++L+ID  P  IRN+G++CT+GPA  SV I+ ++I  GMN+ARLNFSHGTHE H  +I  +R A   L  +   + IALDTKGPEIRTGL+   + GE++L+KG  +K+   +  Y +     I+VDY++I+K++++G  +++DDGLISL V EK   FL+  + N  +LGS+KGVNLP   VDLPAVSE+DK+D+ FAVE  VD++FASFIR  E +  IRK+L +  K+I I++KIEN EG+ +F+EILE +DGIMVARGDLGIEIP EKV  AQKMMI +CN+ G  VICAT MLESM+   RPTRAE SDVANA++DG+DCVMLSGE+AKG YPV+AV MMH I REAE   F    F+ ++  +    D   STAIAAV A+    A  II LT +G +A ++A++RP CPI+ +TR+P  ARQ HLWRG  PI++     +   ++ D R++F++    + GF+      + V+G K+G+  TNTL+++ L    +E+I + + +S
Sbjct:    4 KGAREEYLHDVLNRHKQWISSRARSNLEFRSELDIDKHPLTIRNSGVVCTIGPASRSVEIVAQLIENGMNIARLNFSHGTHEYHRETIMNIRRA--ALLEWPHAVGIALDTKGPEIRTGLL---KAGEIKLEKGQKLKVSTDKAMYDQGHTECIFVDYENIVKVVQIGGTVYVDDGLISLKVLEKGDNFLITEVLNDALLGSKKGVNLPNCAVDLPAVSEQDKKDIAFAVEMEVDMIFASFIRKPEDIAEIRKLLEKHAKNIKIVAKIENHEGVRRFNEILEVADGIMVARGDLGIEIPAEKVFLAQKMMIARCNMKGVPVICATQMLESMVQNPRPTRAETSDVANAILDGADCVMLSGETAKGLYPVQAVAMMHRISREAEAAIFHKQSFDELRHNLEGYADTHISTAIAAVAASFTAGADAIICLTHTGRTAAVVARFRPRCPIVVVTRDPRVARQMHLWRGCFPIVYDQEPLDNVLEEHDQRLDFALGMGKKMGFLTIGSTFVFVSGWKSGAAHTNTLRILTL---TQEKIHIARSLS 537

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BLAST of Pyruvate kinase vs. Ensembl Medaka
Match: pkmb (pyruvate kinase PKM [Source:NCBI gene;Acc:101170426])

HSP 1 Score: 639.032 bits (1647), Expect = 0.000e+0
Identity = 308/505 (60.99%), Postives = 387/505 (76.63%), Query Frame = 1

Query:  238 TNLELVADLNIDSDPGVIRNTGIICTLGPACASVAILHKMIAAGMNVARLNFSHGTHEDHARSIKLLREAIATLKP----YRFPIAIALDTKGPEIRTGLINNNETGEVRLKKGNNIKLVVSEEYYRKCDENFIWVDYKSILKLLKVGNRIFIDDGLISLIVEEKDSEFLLCRIENGGMLGSRKGVNLPGVNVDLPAVSEKDKEDLKFAVEQNVDIVFASFIRNAESVNIIRKILGEKGKHILIISKIENQEGMIQFDEILEASDGIMVARGDLGIEIPPEKVICAQKMMIGKCNVAGKSVICATHMLESMITKSRPTRAEISDVANAVIDGSDCVMLSGESAKGRYPVEAVKMMHTICREAEHLFFQSNFFESIKETVNLPTDHTHSTAIAAVEAAQRCNAAVIIVLTTSGTSAKLIAKYRPSCPILTLTRNPITARQAHLWRGLHPILFSDPRKEEWPKDMDLRINFSINYAYQRGFVKALDIIIIVTGSKAGSGSTNTLQVV 1740
            T +E +  L+IDS+P V RNTGI+CT+GPA  SV +  +MI AGMN+AR+NFSHGTHE HA +IK +REA  +  P    YR P+AIALDTKGPEIRTGLI  + T EV LKKG NIKL + ++Y   CDEN++WVDYK+I K+L+VGN ++IDDGLISL V+E  +++L+C IENGG+LGS+KGVNLPG  VDLPA+SEKD +DL+F +EQ VD+VFASFIR A  V  +RK+LGEKGK + IISK+EN EG+ +FDEILEASDGIMVARGDLGIEIP EKV  AQKMM GKCN  GK +ICAT MLESM  K RPTRAE SDVANAV+DG+DC+MLSGE+AKG YP+EAV   H I REAE   F    FE ++ T +L  D T S AI AVEA+ +C A+ IIVLT SG SA ++++YRP  PIL +TR   TARQAHL+RG++P+L++    + W +D+D+R+NF++ Y   R F K+ D+ I+VTG + GSG TNT++VV
Sbjct:   24 TYIEHMCLLDIDSEPAVSRNTGIVCTIGPASRSVDMAKEMIKAGMNIARMNFSHGTHEYHAETIKNVREATESFGPGTVEYR-PVAIALDTKGPEIRTGLIKGSGTAEVELKKGQNIKLTLDDKYKDNCDENYLWVDYKNITKVLQVGNNVYIDDGLISLKVKEVGNDYLMCEIENGGLLGSKKGVNLPGAAVDLPALSEKDIQDLQFGLEQGVDMVFASFIRKAADVQAVRKVLGEKGKDVKIISKLENHEGVRRFDEILEASDGIMVARGDLGIEIPTEKVFIAQKMMTGKCNRIGKPIICATQMLESMTKKPRPTRAEASDVANAVLDGNDCIMLSGETAKGDYPLEAVLTQHRIAREAEAAMFHRQMFEELRRTSHLTRDPTESVAIGAVEASFKCCASAIIVLTKSGRSAYMLSRYRPRAPILAVTRCGQTARQAHLYRGVYPVLYTKNANDVWAEDVDMRVNFAMEYGKYRKFFKSGDVAIVVTGWRPGSGYTNTMRVV 527

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BLAST of Pyruvate kinase vs. Ensembl Medaka
Match: pkma (pyruvate kinase PKM [Source:NCBI gene;Acc:101170748])

HSP 1 Score: 627.861 bits (1618), Expect = 0.000e+0
Identity = 303/530 (57.17%), Postives = 394/530 (74.34%), Query Frame = 1

Query:  163 MQGARYFEQSNYFFQERRRVHKDYATNLELVADLNIDSDPGVIRNTGIICTLGPACASVAILHKMIAAGMNVARLNFSHGTHEDHARSIKLLREAIATLKP----YRFPIAIALDTKGPEIRTGLINNNETGEVRLKKGNNIKLVVSEEYYRKCDENFIWVDYKSILKLLKVGNRIFIDDGLISLIVEEKDSEFLLCRIENGGMLGSRKGVNLPGVNVDLPAVSEKDKEDLKFAVEQNVDIVFASFIRNAESVNIIRKILGEKGKHILIISKIENQEGMIQFDEILEASDGIMVARGDLGIEIPPEKVICAQKMMIGKCNVAGKSVICATHMLESMITKSRPTRAEISDVANAVIDGSDCVMLSGESAKGRYPVEAVKMMHTICREAEHLFFQSNFFESIKETVNLPTDHTHSTAIAAVEAAQRCNAAVIIVLTTSGTSAKLIAKYRPSCPILTLTRNPITARQAHLWRGLHPILFSDPRKEEWPKDMDLRINFSINYAYQRGFVKALDIIIIVTGSKAGSGSTNTLQVV 1740
            M G++  +  + F Q ++       + LE +  L+IDS+P   RNTGIICT+GPA  SV +L +MI +GMN+AR+NFSHG+HE HA +IK +REA  +  P    YR PI IALDTKGPEIRTGLI  + T EV LKKGN IK+ + + Y   C E  +W+DYK+I K++++G++I+IDDGLISL V E  S+F++C IENGG LGS+KGVNLPG  VDLPAVSEKD +DL+F VEQ VD+VFASFIR A  V+ +RK+LGE+GK+I IISK+EN EG+ +FDEI+EASDGIMVARGDLGIEIP EKV  AQKMMIG+CN AGK + CAT MLESMI K RPTRAE SDVANAV+DG+DC+MLSGE+AKG YP+EAV+  H I REAE   F    FE ++    L  D + + A+ AVE++ +C A+ II LT +G SA LI++YRP  PIL +TRN  TARQAHL+RG+ P+L++ P  + W +D+D+R+NF++     RGF K  D++I++TG + GSG TNT++V+
Sbjct:   19 MPGSKSSDMGSAFIQTQQLNAAMADSFLEHMCLLDIDSEPTTARNTGIICTIGPASRSVEMLKEMIKSGMNIARMNFSHGSHEYHAETIKNVREACESFVPGSIQYR-PIGIALDTKGPEIRTGLIRGSGTAEVELKKGNTIKITLDDAYQENCSEENLWLDYKNITKVVEIGSKIYIDDGLISLQVVEIGSDFIICEIENGGTLGSKKGVNLPGAAVDLPAVSEKDIQDLQFGVEQGVDMVFASFIRKAADVHAVRKVLGERGKNIKIISKLENHEGVRRFDEIMEASDGIMVARGDLGIEIPTEKVFLAQKMMIGRCNRAGKPITCATQMLESMIKKPRPTRAEGSDVANAVLDGADCIMLSGETAKGDYPLEAVRTQHMIAREAEAATFHRQLFEELRRHTQLTRDPSEAVAVGAVESSFKCCASAIITLTKTGRSAHLISRYRPRAPILAVTRNAQTARQAHLYRGIFPVLYTKPAHDVWAEDVDMRVNFAMEMGKARGFFKEGDVVIVLTGWRPGSGYTNTMRVI 547

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Query:  163 MQGARYFEQSNYFFQERRRVHKDYATNLELVADLNIDSDPGVIRNTGIICTLGPACASVAILHKMIAAGMNVARLNFSHGTHEDHARSIKLLREAIATLKP----YRFPIAIALDTKGPEIRTGLINNNETGEVRLKKGNNIKLVVSEEYYRKCDENFIWVDYKSILKLLKVGNRIFIDDGLISLIVEEKDSEFLLCRIENGGMLGSRKGVNLPGVNVDLPAVSEKDKEDLKFAVEQNVDIVFASFIRNAESVNIIRKILGEKGKHILIISKIENQEGMIQFDEILEASDGIMVARGDLGIEIPPEKVICAQKMMIGKCNVAGKSVICATHMLESMITKSRPTRAEISDVANAVIDGSDCVMLSGESAKGRYPVEAVKMMHTICREAEHLFFQSNFFESIKETVNLPTDHTHSTAIAAVEAAQRCNAAVIIVLTTSGTSAKLIAKYRPSCPILTLTRNPITARQAHLWRGLHPILFSDPRKEEWPKDMDLRINFSINYAYQRGFVKALDIIIIVTGSKAGSGSTNTLQVV 1740
            M G++  +  + F Q ++       + LE +  L+IDS+P   RNTGIICT+GPA  SV +L +MI +GMN+AR+NFSHG+HE HA +IK +REA  +  P    YR PI IALDTKGPEIRTGLI  + T EV LKKGN IK+ + + Y   C E  +W+DYK+I K++++G++I+IDDGLISL V E  S+F++C IENGG LGS+KGVNLPG  VDLPAVSEKD +DL+F VEQ VD+VFASFIR A  V+ +RK+LGE+GK+I IISK+EN EG+ +FDEI+EASDGIMVARGDLGIEIP EKV  AQKMMIG+CN AGK + CAT MLESMI K RPTRAE SDVANAV+DG+DC+MLSGE+AKG YP+EAV+  H I REAE   F    FE ++    L  D + + A+ AVE++ +C A+ II LT +G SA LI++YRP  PIL +TRN  TARQAHL+RG+ P+L++ P  + W +D+D+R+NF++     RGF K  D++I++TG + GSG TNT++V+
Sbjct:    1 MPGSKSSDMGSAFIQTQQLNAAMADSFLEHMCLLDIDSEPTTARNTGIICTIGPASRSVEMLKEMIKSGMNIARMNFSHGSHEYHAETIKNVREACESFVPGSIQYR-PIGIALDTKGPEIRTGLIRGSGTAEVELKKGNTIKITLDDAYQENCSEENLWLDYKNITKVVEIGSKIYIDDGLISLQVVEIGSDFIICEIENGGTLGSKKGVNLPGAAVDLPAVSEKDIQDLQFGVEQGVDMVFASFIRKAADVHAVRKVLGERGKNIKIISKLENHEGVRRFDEIMEASDGIMVARGDLGIEIPTEKVFLAQKMMIGRCNRAGKPITCATQMLESMIKKPRPTRAEGSDVANAVLDGADCIMLSGETAKGDYPLEAVRTQHMIAREAEAATFHRQLFEELRRHTQLTRDPSEAVAVGAVESSFKCCASAIITLTKTGRSAHLISRYRPRAPILAVTRNAQTARQAHLYRGIFPVLYTKPAHDVWAEDVDMRVNFAMEMGKARGFFKEGDVVIVLTGWRPGSGYTNTMRVI 529

[Close]

BLAST of Pyruvate kinase vs. Ensembl Medaka
Match: pkma (pyruvate kinase PKM [Source:NCBI gene;Acc:101170748])

HSP 1 Score: 625.55 bits (1612), Expect = 0.000e+0
Identity = 305/530 (57.55%), Postives = 394/530 (74.34%), Query Frame = 1

Query:  163 MQGARYFEQSNYFFQERRRVHKDYATNLELVADLNIDSDPGVIRNTGIICTLGPACASVAILHKMIAAGMNVARLNFSHGTHEDHARSIKLLREAIATLKP----YRFPIAIALDTKGPEIRTGLINNNETGEVRLKKGNNIKLVVSEEYYRKCDENFIWVDYKSILKLLKVGNRIFIDDGLISLIVEEKDSEFLLCRIENGGMLGSRKGVNLPGVNVDLPAVSEKDKEDLKFAVEQNVDIVFASFIRNAESVNIIRKILGEKGKHILIISKIENQEGMIQFDEILEASDGIMVARGDLGIEIPPEKVICAQKMMIGKCNVAGKSVICATHMLESMITKSRPTRAEISDVANAVIDGSDCVMLSGESAKGRYPVEAVKMMHTICREAEHLFFQSNFFESIKETVNLPTDHTHSTAIAAVEAAQRCNAAVIIVLTTSGTSAKLIAKYRPSCPILTLTRNPITARQAHLWRGLHPILFSDPRKEEWPKDMDLRINFSINYAYQRGFVKALDIIIIVTGSKAGSGSTNTLQVV 1740
            M G++  +  + F Q ++       + LE +  L+IDS+P   RNTGIICT+GPA  SV +L +MI +GMN+AR+NFSHG+HE HA +IK +REA  +  P    YR PI IALDTKGPEIRTGLI  + T EV LKKGN IK+ + + Y   C E  +W+DYK+I K++++G++I+IDDGLISL V E  S+F++C IENGG LGS+KGVNLPG  VDLPAVSEKD +DL+F VEQ VD+VFASFIR A  V+ +RK+LGE+GK+I IISK+EN EG+ +FDEI+EASDGIMVARGDLGIEIP EKV  AQKMMIG+CN AGK + CAT MLESMI K RPTRAE SDVANAV+DG+DC+MLSGE+AKG YP+EAV+  H I REAE   F    FE ++ +    +D   + AI AVEA+ +  A+ IIVLT SG SA LI++YRP  PIL +TRN  TARQAHL+RG+ P+L++ P  + W +D+D+R+NF++     RGF K  D++I++TG + GSG TNT++V+
Sbjct:    1 MPGSKSSDMGSAFIQTQQLNAAMADSFLEHMCLLDIDSEPTTARNTGIICTIGPASRSVEMLKEMIKSGMNIARMNFSHGSHEYHAETIKNVREACESFVPGSIQYR-PIGIALDTKGPEIRTGLIRGSGTAEVELKKGNTIKITLDDAYQENCSEENLWLDYKNITKVVEIGSKIYIDDGLISLQVVEIGSDFIICEIENGGTLGSKKGVNLPGAAVDLPAVSEKDIQDLQFGVEQGVDMVFASFIRKAADVHAVRKVLGERGKNIKIISKLENHEGVRRFDEIMEASDGIMVARGDLGIEIPTEKVFLAQKMMIGRCNRAGKPITCATQMLESMIKKPRPTRAEGSDVANAVLDGADCIMLSGETAKGDYPLEAVRTQHMIAREAEAAMFHRQVFEDLRRSTPHCSDPAEAIAIGAVEASFKSLASAIIVLTGSGRSAHLISRYRPRAPILAVTRNAQTARQAHLYRGIFPVLYTKPAHDVWAEDVDMRVNFAMEMGKARGFFKEGDVVIVLTGWRPGSGYTNTMRVI 529

[Close]

BLAST of Pyruvate kinase vs. Ensembl Medaka
Match: pklr (pyruvate kinase PKM [Source:NCBI gene;Acc:101161188])

HSP 1 Score: 558.91 bits (1439), Expect = 0.000e+0
Identity = 277/518 (53.47%), Postives = 369/518 (71.24%), Query Frame = 1

Query:  202 FQERRRVHKDYA-TNLELVADLNIDSDPGVIRNTGIICTLGPACASVAILHKMIAAGMNVARLNFSHGTHEDHARSIKLLREAIATLKP---YRFPIAIALDTKGPEIRTGLINNNETGEVRLKKGNNIKLVVSEEYYRKCDENFIWVDYKSILKLLKVGNRIFIDDGLISLIVEEKDSEFLLCRIENGGMLGSRKGVNLPGVN-VDLPAVSEKDKEDLKFAVEQNVDIVFASFIRNAESVNIIRKILGEKGKHILIISKIENQEGMIQFDEILEASDGIMVARGDLGIEIPPEKVICAQKMMIGKCNVAGKSVICATHMLESMITKSRPTRAEISDVANAVIDGSDCVMLSGESAKGRYPVEAVKMMHTICREAEHLFFQSNFFESIKETVNLPTDHTHSTAIAAVEAAQRCNAAVIIVLTTSGTSAKLIAKYRPSCPILTLTRNPITARQAHLWRGLHPILFSDPRKEEWPKDMDLRINFSINYAYQRGFVKALDIIIIVTGSKAGSGSTNTLQVV 1740
            F +R+++    A T LE +  L+ID +P   RNT IICT+GPA  S+  L +M+ AGMN+ARLNFSHG HE H+ +IK +REA+ T+     Y  P+AIALDTKGPEIRTGL+      EV+L KG+++++V +E    K D   +WVDY  + K+L+ G RI+IDDGL++L V E  S+++   +E GG+L SRKGVNLPG + + L AVSE+D+ DL+F V   VD+VFASFIR+A+ V  +R+ LGE G HI +ISK+E+++G+  F+EIL  SDG+MVARGDLGIEIP EKV  AQKMMIG+CN AGK VICAT MLESM++  RPTRAE SDVANAV+DG+DCVMLS E+AKG++P+EAV MMH+ICREAE   F    FE ++    L +D T  TAI AVE++ +C A  IIVLT+SG S+ L+++YRP CPI+ +TR+P  ARQ+ L RG+ P LF       W  D+D R+ F ++    RGF K+ D++I+VTG   GSG TN ++ V
Sbjct:   23 FIQRQQLDASMADTFLEHLCLLDIDQEPITARNTSIICTIGPASRSIQKLQEMVKAGMNIARLNFSHGCHEYHSETIKNIREAVETITSDPLYYRPVAIALDTKGPEIRTGLVKGKVDEEVQLVKGSHVRVVTAESERDKTDATMVWVDYPHLPKVLEKGRRIYIDDGLLALKVLEIGSDWVDTVVEAGGLLCSRKGVNLPGCDLIGLQAVSEQDEADLRFGVAHGVDMVFASFIRSAQDVKDVRRALGELGSHIKVISKVESRQGVQNFEEILAESDGVMVARGDLGIEIPAEKVFIAQKMMIGRCNSAGKPVICATQMLESMVSHPRPTRAESSDVANAVLDGADCVMLSAETAKGKFPLEAVAMMHSICREAEAAIFHHQLFEELRRLTPLSSDPTEVTAIGAVESSFKCCAGAIIVLTSSGRSSHLLSRYRPRCPIIAVTRSPQVARQSQLLRGVFPALFHPLPAPVWADDVDSRVKFGMDIGKARGFFKSGDMVIVVTGWIPGSGHTNIMRAV 540

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BLAST of Pyruvate kinase vs. Planmine SMEST
Match: SMESG000017671.1 (SMESG000017671.1)

HSP 1 Score: 1136.71 bits (2939), Expect = 0.000e+0
Identity = 551/553 (99.64%), Postives = 552/553 (99.82%), Query Frame = 1

Query:  160 MMQGARYFEQSNYFFQERRRVHKDYATNLELVADLNIDSDPGVIRNTGIICTLGPACASVAILHKMIAAGMNVARLNFSHGTHEDHARSIKLLREAIATLKPYRFPIAIALDTKGPEIRTGLINNNETGEVRLKKGNNIKLVVSEEYYRKCDENFIWVDYKSILKLLKVGNRIFIDDGLISLIVEEKDSEFLLCRIENGGMLGSRKGVNLPGVNVDLPAVSEKDKEDLKFAVEQNVDIVFASFIRNAESVNIIRKILGEKGKHILIISKIENQEGMIQFDEILEASDGIMVARGDLGIEIPPEKVICAQKMMIGKCNVAGKSVICATHMLESMITKSRPTRAEISDVANAVIDGSDCVMLSGESAKGRYPVEAVKMMHTICREAEHLFFQSNFFESIKETVNLPTDHTHSTAIAAVEAAQRCNAAVIIVLTTSGTSAKLIAKYRPSCPILTLTRNPITARQAHLWRGLHPILFSDPRKEEWPKDMDLRINFSINYAYQRGFVKALDIIIIVTGSKAGSGSTNTLQVVKLEIDEKEEIGLKKYISYPTIKEFDD 1818
            MMQGARYFEQSNYFFQERRRVHKDYATNLELVADLNIDSDPGVIRNTGIICTLGPACASVAILHKMIAAGMNVARLNFSHGTHEDHARSIKLLREAIATLKPYRFPIAIALDTKGPEIRTGLINNNETGEVRL KGNNIKLVVSEEYYRKCDENFIWVDYKSILKLLKVGNRIFIDDGLISLIVEEKDSEFLLCRIENGGMLGSRKGVNLPGVNVDLPAVSEKDKEDLKFAVEQNVDIVFASFIRNAESVNIIRKILGEKGKHILIISKIENQEGMIQFDEILEASDGIMVARGDLGIEIPPEKVICAQKMMIGKCNVAGKSVICATHMLESMITKSRPTRAEISDVANAVIDGSDCVMLSGESAKGRYPVEAVKMMHTICREAEHLFFQSNFFESIKETVNLPTDHTHSTAIAAVEAAQRCNAAVIIVLTTSGTSAKLIAKYRPSCPILTLTRNPITARQAHLWRGLHPILFSDPRK+EWPKDMDLRINFSINYAYQRGFVKALDIIIIVTGSKAGSGSTNTLQVVKLEIDEKEEIGLKKYISYPTIKEFDD
Sbjct:    1 MMQGARYFEQSNYFFQERRRVHKDYATNLELVADLNIDSDPGVIRNTGIICTLGPACASVAILHKMIAAGMNVARLNFSHGTHEDHARSIKLLREAIATLKPYRFPIAIALDTKGPEIRTGLINNNETGEVRLIKGNNIKLVVSEEYYRKCDENFIWVDYKSILKLLKVGNRIFIDDGLISLIVEEKDSEFLLCRIENGGMLGSRKGVNLPGVNVDLPAVSEKDKEDLKFAVEQNVDIVFASFIRNAESVNIIRKILGEKGKHILIISKIENQEGMIQFDEILEASDGIMVARGDLGIEIPPEKVICAQKMMIGKCNVAGKSVICATHMLESMITKSRPTRAEISDVANAVIDGSDCVMLSGESAKGRYPVEAVKMMHTICREAEHLFFQSNFFESIKETVNLPTDHTHSTAIAAVEAAQRCNAAVIIVLTTSGTSAKLIAKYRPSCPILTLTRNPITARQAHLWRGLHPILFSDPRKDEWPKDMDLRINFSINYAYQRGFVKALDIIIIVTGSKAGSGSTNTLQVVKLEIDEKEEIGLKKYISYPTIKEFDD 553

[Close]

BLAST of Pyruvate kinase vs. Planmine SMEST
Match: SMESG000017671.1 (SMESG000017671.1)

HSP 1 Score: 1134.4 bits (2933), Expect = 0.000e+0
Identity = 550/552 (99.64%), Postives = 551/552 (99.82%), Query Frame = 1

Query:  163 MQGARYFEQSNYFFQERRRVHKDYATNLELVADLNIDSDPGVIRNTGIICTLGPACASVAILHKMIAAGMNVARLNFSHGTHEDHARSIKLLREAIATLKPYRFPIAIALDTKGPEIRTGLINNNETGEVRLKKGNNIKLVVSEEYYRKCDENFIWVDYKSILKLLKVGNRIFIDDGLISLIVEEKDSEFLLCRIENGGMLGSRKGVNLPGVNVDLPAVSEKDKEDLKFAVEQNVDIVFASFIRNAESVNIIRKILGEKGKHILIISKIENQEGMIQFDEILEASDGIMVARGDLGIEIPPEKVICAQKMMIGKCNVAGKSVICATHMLESMITKSRPTRAEISDVANAVIDGSDCVMLSGESAKGRYPVEAVKMMHTICREAEHLFFQSNFFESIKETVNLPTDHTHSTAIAAVEAAQRCNAAVIIVLTTSGTSAKLIAKYRPSCPILTLTRNPITARQAHLWRGLHPILFSDPRKEEWPKDMDLRINFSINYAYQRGFVKALDIIIIVTGSKAGSGSTNTLQVVKLEIDEKEEIGLKKYISYPTIKEFDD 1818
            MQGARYFEQSNYFFQERRRVHKDYATNLELVADLNIDSDPGVIRNTGIICTLGPACASVAILHKMIAAGMNVARLNFSHGTHEDHARSIKLLREAIATLKPYRFPIAIALDTKGPEIRTGLINNNETGEVRL KGNNIKLVVSEEYYRKCDENFIWVDYKSILKLLKVGNRIFIDDGLISLIVEEKDSEFLLCRIENGGMLGSRKGVNLPGVNVDLPAVSEKDKEDLKFAVEQNVDIVFASFIRNAESVNIIRKILGEKGKHILIISKIENQEGMIQFDEILEASDGIMVARGDLGIEIPPEKVICAQKMMIGKCNVAGKSVICATHMLESMITKSRPTRAEISDVANAVIDGSDCVMLSGESAKGRYPVEAVKMMHTICREAEHLFFQSNFFESIKETVNLPTDHTHSTAIAAVEAAQRCNAAVIIVLTTSGTSAKLIAKYRPSCPILTLTRNPITARQAHLWRGLHPILFSDPRK+EWPKDMDLRINFSINYAYQRGFVKALDIIIIVTGSKAGSGSTNTLQVVKLEIDEKEEIGLKKYISYPTIKEFDD
Sbjct:    1 MQGARYFEQSNYFFQERRRVHKDYATNLELVADLNIDSDPGVIRNTGIICTLGPACASVAILHKMIAAGMNVARLNFSHGTHEDHARSIKLLREAIATLKPYRFPIAIALDTKGPEIRTGLINNNETGEVRLIKGNNIKLVVSEEYYRKCDENFIWVDYKSILKLLKVGNRIFIDDGLISLIVEEKDSEFLLCRIENGGMLGSRKGVNLPGVNVDLPAVSEKDKEDLKFAVEQNVDIVFASFIRNAESVNIIRKILGEKGKHILIISKIENQEGMIQFDEILEASDGIMVARGDLGIEIPPEKVICAQKMMIGKCNVAGKSVICATHMLESMITKSRPTRAEISDVANAVIDGSDCVMLSGESAKGRYPVEAVKMMHTICREAEHLFFQSNFFESIKETVNLPTDHTHSTAIAAVEAAQRCNAAVIIVLTTSGTSAKLIAKYRPSCPILTLTRNPITARQAHLWRGLHPILFSDPRKDEWPKDMDLRINFSINYAYQRGFVKALDIIIIVTGSKAGSGSTNTLQVVKLEIDEKEEIGLKKYISYPTIKEFDD 552

[Close]

BLAST of Pyruvate kinase vs. Planmine SMEST
Match: SMESG000017675.1 (SMESG000017675.1)

HSP 1 Score: 789.645 bits (2038), Expect = 0.000e+0
Identity = 366/554 (66.06%), Postives = 465/554 (83.94%), Query Frame = 1

Query:  157 LMMQGARYFEQSNYFFQERRRVHKDYATNLELVADLNIDSDPGVIRNTGIICTLGPACASVAILHKMIAAGMNVARLNFSHGTHEDHARSIKLLREAIATLKPYRFPIAIALDTKGPEIRTGLINNNETGEVRLKKGNNIKLVVSEEYYRKCDENFIWVDYKSILKLLKVGNRIFIDDGLISLIVEEKDSEFLLCRIENGGMLGSRKGVNLPGVNVDLPAVSEKDKEDLKFAVEQNVDIVFASFIRNAESVNIIRKILGEKGKHILIISKIENQEGMIQFDEILEASDGIMVARGDLGIEIPPEKVICAQKMMIGKCNVAGKSVICATHMLESMITKSRPTRAEISDVANAVIDGSDCVMLSGESAKGRYPVEAVKMMHTICREAEHLFFQSNFFESIKETVNLPTDHTHSTAIAAVEAAQRCNAAVIIVLTTSGTSAKLIAKYRPSCPILTLTRNPITARQAHLWRGLHPILFSDPRKEEWPKDMDLRINFSINYAYQRGFVKALDIIIIVTGSKAGSGSTNTLQVVKLEIDEKEEIGLKKYISYPTIKEFDD 1818
            + + G++YFE +NYF Q +R    DY +NLE  + LN + +PGVIRN+GIICT+GPAC SV ILHKMI+AGMNVARLNFSHGT+E H  +I L+REA+ T KPY  PIAIALDTKGPEIRTGL+N + TGEV L KG+ IK+VV  +Y  +C+ + +WVDY +I+ +L+V + I+IDDGLISL+V +K S+FL+C +ENGG+LGS+KGVNLPG  VDLPAVSEKDKEDL+F VE NVD+VFASFIR+  ++  I+ ILGEKGKHILIISKIEN EG+ +FDEILE SDGIMVARGDLGIEIPPEKV+ AQKMMIG+CN AGK VICAT MLESMI K  PT+AEISDVANAV+DG+DCVMLSGE+AKG+YP+EAV++MH+ICREAE++ +QS FFE+IK T++ PTD THSTA+AAVEAAQRC+AA IIV+TT+G SA LIAKYRP+CPILT+TR+PITARQ+HLWRGLHPI +++PR  +W +DMD RI++S++Y ++RGF++  D +IIVTG KAG GSTNTL+++++E ++ +  G+++ +S P I EF+D
Sbjct:    1 MKLNGSKYFEPTNYFIQNQRITSNDYRSNLEHTSKLNYNDEPGVIRNSGIICTIGPACKSVTILHKMISAGMNVARLNFSHGTYEYHEETINLVREAVDTFKPYFRPIAIALDTKGPEIRTGLVNGSATGEVNLYKGSTIKIVVDNKYSEQCNSSQLWVDYVNIINILEVNSSIYIDDGLISLVVIKKGSDFLMCEVENGGLLGSKKGVNLPGAKVDLPAVSEKDKEDLRFGVEHNVDMVFASFIRSGNAIKEIKDILGEKGKHILIISKIENLEGVQKFDEILEISDGIMVARGDLGIEIPPEKVVLAQKMMIGRCNRAGKPVICATQMLESMINKPTPTKAEISDVANAVLDGADCVMLSGETAKGQYPLEAVQVMHSICREAENVLYQSKFFEAIKHTISGPTDQTHSTAVAAVEAAQRCHAAAIIVITTTGRSAHLIAKYRPTCPILTVTRHPITARQSHLWRGLHPIFYNEPRMIDWTEDMDERIHYSLSYGFRRGFLQMNDFVIIVTGWKAGVGSTNTLRIIRIEENQLQS-GVRQIVSVPIISEFED 553

[Close]

BLAST of Pyruvate kinase vs. Planmine SMEST
Match: SMESG000052083.1 (SMESG000052083.1)

HSP 1 Score: 734.176 bits (1894), Expect = 0.000e+0
Identity = 352/554 (63.54%), Postives = 439/554 (79.24%), Query Frame = 1

Query:  160 MMQGARYFEQSNYFFQERRRVHKDYA-TNLELVADLNIDSDPGVIRNTGIICTLGPACASVAILHKMIAAGMNVARLNFSHGTHEDHARSIKLLREAIATLKPYRFPIAIALDTKGPEIRTGLINNNETGEVRLKKGNNIKLVVSEEYYRKCDENFIWVDYKSILKLLKVGNRIFIDDGLISLIVEEKDSEFLLCRIENGGMLGSRKGVNLPGVNVDLPAVSEKDKEDLKFAVEQNVDIVFASFIRNAESVNIIRKILGEKGKHILIISKIENQEGMIQFDEILEASDGIMVARGDLGIEIPPEKVICAQKMMIGKCNVAGKSVICATHMLESMITKSRPTRAEISDVANAVIDGSDCVMLSGESAKGRYPVEAVKMMHTICREAEHLFFQSNFFESIKETVNLPTDHTHSTAIAAVEAAQRCNAAVIIVLTTSGTSAKLIAKYRPSCPILTLTRNPITARQAHLWRGLHPILFSDPRKEEWPKDMDLRINFSINYAYQRGFVKALDIIIIVTGSKAGSGSTNTLQVVKLEIDEKEEIGLKKYISYPTIKEFDD 1818
            M +    FE +NYF Q +  VH+  + ++LE + +L+ID++P V+R++ IICT+GPAC +V+ L KMIA+GMN+AR+NFSHG+HE HA +IKL+REA+ T  PY  P+A+ALDTKGPEIRTGLI+ + TGEV L KGN IKLV+ E+Y   C+E  +WVDYK+I+K+L  G RI++DDGLISLIV E   ++L C +ENGG LGS+KGVNLPG  VDLPAVS+KD  DL F VEQ VD+VFASFIR   +V+ IR ILGEKGKHILIISKIEN EG+ +FDEIL+ASDGIMVARGDLGIEIP EKV  AQKMMIG+CN  GK +ICAT MLESMITK RPTRAE SDVANA++DG+DCVMLSGE+AKG YP+EAV++MH ICREAE   FQ  FFE +K  +   TD THSTAIAAVEAAQRC A+ I+V+TT+G SA LI++YRP CPILT+TR+P+TARQ HLWRG+HP+L+   R +EW  DMD RIN++  YA +RGFVK  D +I+VTG KAGSGSTNT++V+ LE D  E+ G+   +S P+I +F+D
Sbjct:    1 MKKNPSSFEINNYFIQNQN-VHRGVSRSHLEFICNLDIDNEPDVVRSSSIICTIGPACRTVSTLKKMIASGMNIARMNFSHGSHEYHAETIKLVREAVETFTPYYRPVALALDTKGPEIRTGLIHGSGTGEVTLVKGNKIKLVIDEKYADSCNEEILWVDYKNIVKILHKGCRIYVDDGLISLIVVETGKDYLDCEVENGGNLGSKKGVNLPGAKVDLPAVSDKDISDLHFGVEQGVDMVFASFIRCGAAVDEIRAILGEKGKHILIISKIENHEGVKRFDEILQASDGIMVARGDLGIEIPAEKVFLAQKMMIGRCNRLGKPIICATQMLESMITKPRPTRAESSDVANAILDGADCVMLSGETAKGAYPLEAVQIMHHICREAESAVFQGKFFEDLKGEIVGSTDQTHSTAIAAVEAAQRCRASAIVVVTTTGRSAYLISRYRPRCPILTVTRHPVTARQGHLWRGVHPLLYDAKRLDEWTTDMDNRINWAFGYAMRRGFVKNGDYVIVVTGWKAGSGSTNTMRVILLEDDANEKDGIMPILSIPSIAKFED 553

[Close]

BLAST of Pyruvate kinase vs. Planmine SMEST
Match: SMESG000006009.1 (SMESG000006009.1)

HSP 1 Score: 676.011 bits (1743), Expect = 0.000e+0
Identity = 329/530 (62.08%), Postives = 413/530 (77.92%), Query Frame = 1

Query:  160 MMQGARYFEQSNYFFQERRRVHKDYATNLELVADLNIDSDPGVIRNTGIICTLGPACASVAILHKMIAAGMNVARLNFSHGTHEDHARSIKLLREAIATLKPYRFPIAIALDTKGPEIRTGLINNNETGEVRLKKGNNIKLVVSEEYYRKCDENFIWVDYKSILKLLKVGNRIFIDDGLISLIVEEKDSEFLLCRIENGGMLGSRKGVNLPGVNVDLPAVSEKDKEDLKFAVEQNVDIVFASFIRNAESVNIIRKILGEKGKHILIISKIENQEGMIQFDEILEASDGIMVARGDLGIEIPPEKVICAQKMMIGKCNVAGKSVICATHMLESMITKSRPTRAEISDVANAVIDGSDCVMLSGESAKGRYPVEAVKMMHTICREAEHLFFQSNFFESIKETVNLPTDHTHSTAIAAVEAAQRCNAAVIIVLTTSGTSAKLIAKYRPSCPILTLTRNPITARQAHLWRGLHPILFSDPRKEEWPKDMDLRINFSINYAYQRGFVKALDIIIIVTGSKAGSGSTNTLQVVKLE 1749
            M   +   E+S+   Q+R   +K     L  + DL+IDSDPG +RNTGIICT+GPAC S+  LH M+++GMNVARLNFSHGTHE HA +IKL+REAI T KP+R PIAIALDTKGPEIRTGLI  + T E+ L  G  I++V  + +  KCDE  +W+DYK+I  +L +GN+I+IDDGLISLIV+ K  ++L C++ENGG+LGS+KGVNLPG  VDLPAVSEKDK+DLKF VEQNVDIVFASFIRNA+++  IR ILGE+GKHILII+KIEN EG+ + DEI+E +DGIMVARGD+GIEIP +KV+ AQKMMI KCN  GK VICAT MLESM++K RPTRAEISDVANAV+DGSDCVMLSGESAKG +P++AVK MH +C+EAE +FFQ+ + + IK       +H  ++AIAAVEAAQ   A+ IIVLTT+G S+ LI+KYRP CPIL +TRN + ARQ HLWRGLHP+L   PR + W +D+D RI+ SI Y Y+ G +K  D ++IVTG K  SGSTNT+++V ++
Sbjct:    1 MSTNSSSVEKSDSLTQKRFMKNKPDCV-LSHLCDLDIDSDPGSVRNTGIICTIGPACKSIKTLHGMMSSGMNVARLNFSHGTHEYHAETIKLVREAIETFKPHRRPIAIALDTKGPEIRTGLIRGSGTAEINLVDGQQIRIVTDDIFAEKCDEKNLWLDYKNITNILDIGNKIYIDDGLISLIVQAKGKDYLDCKVENGGLLGSKKGVNLPGAQVDLPAVSEKDKQDLKFGVEQNVDIVFASFIRNADAIREIRSILGEEGKHILIIAKIENHEGIKRIDEIIEEADGIMVARGDMGIEIPAQKVVVAQKMMIAKCNKQGKPVICATQMLESMVSKPRPTRAEISDVANAVLDGSDCVMLSGESAKGSFPIQAVKTMHEVCKEAEAIFFQNKYLQEIKNVNRHFNNHVEASAIAAVEAAQLSKASAIIVLTTTGNSSHLISKYRPRCPILAVTRNEVVARQCHLWRGLHPLLVEFPRLDNWSEDVDARIDCSIQYGYKSGILKKGDSVVIVTGWKPVSGSTNTIRIVNVD 529

The following BLAST results are available for this feature:

BLAST of Pyruvate kinase vs. Ensembl Human
BLAST of Pyruvate kinase vs. Ensembl Celegans
BLAST of Pyruvate kinase vs. Ensembl Fly
BLAST of Pyruvate kinase vs. Ensembl Zebrafish
BLAST of Pyruvate kinase vs. Ensembl Xenopus
BLAST of Pyruvate kinase vs. Ensembl Mouse
BLAST of Pyruvate kinase vs. UniProt/SwissProt
BLAST of Pyruvate kinase vs. TrEMBL
BLAST of Pyruvate kinase vs. Ensembl Cavefish
BLAST of Pyruvate kinase vs. Ensembl Sea Lamprey
BLAST of Pyruvate kinase vs. Ensembl Yeast
BLAST of Pyruvate kinase vs. Ensembl Nematostella
BLAST of Pyruvate kinase vs. Ensembl Medaka
BLAST of Pyruvate kinase vs. Planmine SMEST

BLAST of Pyruvate kinase vs. Ensembl Human
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Human e!99)
Total hits: 5


Match Name	E-value	Identity	Description
PKM	0.000e+0	60.00	pyruvate kinase M1/2 [Source:HGNC Symbol;Acc:HGNC:...	[more]
PKM	0.000e+0	60.23	pyruvate kinase M1/2 [Source:HGNC Symbol;Acc:HGNC:...	[more]
PKM	0.000e+0	60.23	pyruvate kinase M1/2 [Source:HGNC Symbol;Acc:HGNC:...	[more]
PKM	0.000e+0	60.23	pyruvate kinase M1/2 [Source:HGNC Symbol;Acc:HGNC:...	[more]
PKM	0.000e+0	60.23	pyruvate kinase M1/2 [Source:HGNC Symbol;Acc:HGNC:...	[more]

BLAST of Pyruvate kinase vs. Ensembl Celegans
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99)
Total hits: 5


Match Name	E-value	Identity	Description
pyk-2	0.000e+0	56.32	Pyruvate kinase [Source:UniProtKB/TrEMBL;Acc:Q235...	[more]
pyk-2	0.000e+0	56.69	Pyruvate kinase [Source:UniProtKB/TrEMBL;Acc:Q235...	[more]
pyk-1	0.000e+0	55.68	Pyruvate kinase [Source:UniProtKB/TrEMBL;Acc:Q7JL...	[more]
pyk-1	0.000e+0	55.68	Pyruvate kinase [Source:UniProtKB/TrEMBL;Acc:Q7JL...	[more]
pyk-1	0.000e+0	55.24	Pyruvate kinase [Source:UniProtKB/TrEMBL;Acc:Q7JL...	[more]

BLAST of Pyruvate kinase vs. Ensembl Fly
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99)
Total hits: 5


Match Name	E-value	Identity	Description
PyK	0.000e+0	57.79	gene:FBgn0267385 transcript:FBtr0084213	[more]
PyK	0.000e+0	57.79	gene:FBgn0267385 transcript:FBtr0084214	[more]
CG2964	1.339e-143	43.36	gene:FBgn0031462 transcript:FBtr0077722	[more]
CG7069	1.409e-136	50.98	gene:FBgn0038952 transcript:FBtr0084215	[more]
CG7362	6.836e-70	46.13	gene:FBgn0038258 transcript:FBtr0331700	[more]

BLAST of Pyruvate kinase vs. Ensembl Zebrafish
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99)
Total hits: 5


Match Name	E-value	Identity	Description
pkma	0.000e+0	57.33	pyruvate kinase M1/2a [Source:ZFIN;Acc:ZDB-GENE-03...	[more]
pkma	0.000e+0	57.33	pyruvate kinase M1/2a [Source:ZFIN;Acc:ZDB-GENE-03...	[more]
pkma	0.000e+0	57.52	pyruvate kinase M1/2a [Source:ZFIN;Acc:ZDB-GENE-03...	[more]
pkmb	0.000e+0	59.65	pyruvate kinase M1/2b [Source:ZFIN;Acc:ZDB-GENE-04...	[more]
pkmb	0.000e+0	59.65	pyruvate kinase M1/2b [Source:ZFIN;Acc:ZDB-GENE-04...	[more]

BLAST of Pyruvate kinase vs. Ensembl Xenopus
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99)
Total hits: 5


Match Name	E-value	Identity	Description
pkm	0.000e+0	59.62	pyruvate kinase M1/2 [Source:NCBI gene;Acc:549224]	[more]
pkm	0.000e+0	59.81	pyruvate kinase M1/2 [Source:NCBI gene;Acc:549224]	[more]
pkm	0.000e+0	59.81	pyruvate kinase M1/2 [Source:NCBI gene;Acc:549224]	[more]
pkm	0.000e+0	60.00	pyruvate kinase M1/2 [Source:NCBI gene;Acc:549224]	[more]
pkm	0.000e+0	56.47	pyruvate kinase M1/2 [Source:NCBI gene;Acc:549224]	[more]

BLAST of Pyruvate kinase vs. Ensembl Mouse
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99)
Total hits: 5


Match Name	E-value	Identity	Description
Pkm	0.000e+0	59.85	pyruvate kinase, muscle [Source:MGI Symbol;Acc:MGI...	[more]
Pkm	0.000e+0	59.43	pyruvate kinase, muscle [Source:MGI Symbol;Acc:MGI...	[more]
Pklr	0.000e+0	54.01	pyruvate kinase liver and red blood cell [Source:M...	[more]
Pklr	0.000e+0	54.01	pyruvate kinase liver and red blood cell [Source:M...	[more]
Pkm	5.151e-82	58.56	pyruvate kinase, muscle [Source:MGI Symbol;Acc:MGI...	[more]

BLAST of Pyruvate kinase vs. UniProt/SwissProt
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt)
Total hits: 5


Match Name	E-value	Identity	Description
sp\|P14618\|KPYM_HUMAN	0.000e+0	60.00	Pyruvate kinase PKM OS=Homo sapiens OX=9606 GN=PKM...	[more]
sp\|Q5NVN0\|KPYM_PONAB	0.000e+0	60.23	Pyruvate kinase PKM OS=Pongo abelii OX=9601 GN=PKM...	[more]
sp\|P11979\|KPYM_FELCA	0.000e+0	60.54	Pyruvate kinase PKM OS=Felis catus OX=9685 GN=PKM ...	[more]
sp\|P11980\|KPYM_RAT	0.000e+0	59.66	Pyruvate kinase PKM OS=Rattus norvegicus OX=10116 ...	[more]
sp\|P11974\|KPYM_RABIT	0.000e+0	58.71	Pyruvate kinase PKM OS=Oryctolagus cuniculus OX=99...	[more]

BLAST of Pyruvate kinase vs. TrEMBL
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL)
Total hits: 5


Match Name	E-value	Identity	Description
A0A267F274	0.000e+0	61.37	Pyruvate kinase OS=Macrostomum lignano OX=282301 G...	[more]
A0A267EYV5	0.000e+0	61.49	Pyruvate kinase (Fragment) OS=Macrostomum lignano ...	[more]
A0A430Q112	0.000e+0	61.90	Pyruvate kinase OS=Schistosoma bovis OX=6184 GN=DC...	[more]
A0A095B084	0.000e+0	61.71	Pyruvate kinase OS=Schistosoma haematobium OX=6185...	[more]
A0A3Q0KH21	0.000e+0	59.56	Pyruvate kinase OS=Schistosoma mansoni OX=6183 PE=...	[more]

BLAST of Pyruvate kinase vs. Ensembl Cavefish
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99)
Total hits: 5


Match Name	E-value	Identity	Description
pkma	0.000e+0	59.80	pyruvate kinase PKM [Source:NCBI gene;Acc:10304421...	[more]
pkma	0.000e+0	59.57	pyruvate kinase PKM [Source:NCBI gene;Acc:10304421...	[more]
pkma	0.000e+0	59.57	pyruvate kinase PKM [Source:NCBI gene;Acc:10304421...	[more]
pkma	0.000e+0	59.57	pyruvate kinase PKM [Source:NCBI gene;Acc:10304421...	[more]
pkmb	0.000e+0	60.79	pyruvate kinase PKM-like [Source:NCBI gene;Acc:103...	[more]

BLAST of Pyruvate kinase vs. Ensembl Sea Lamprey
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99)
Total hits: 1


Match Name	E-value	Identity	Description
pkma	0.000e+0	56.25	pyruvate kinase M1/2a [Source:ZFIN;Acc:ZDB-GENE-03...	[more]

BLAST of Pyruvate kinase vs. Ensembl Yeast
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46)
Total hits: 3


Match Name	E-value	Identity	Description
CDC19	8.551e-152	47.51	Pyruvate kinase; functions as a homotetramer in gl...	[more]
PYK2	1.224e-137	44.14	Pyruvate kinase; appears to be modulated by phosph...	[more]
YAL037C-B_mRNA	4.497e-34	26.81	Dubious open reading frame; unlikely to encode a f...	[more]

BLAST of Pyruvate kinase vs. Ensembl Nematostella
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46)
Total hits: 1


Match Name	E-value	Identity	Description
EDO49963	1.948e-179	48.52	Pyruvate kinase [Source:UniProtKB/TrEMBL;Acc:A7RE...	[more]

BLAST of Pyruvate kinase vs. Ensembl Medaka
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99)
Total hits: 5


Match Name	E-value	Identity	Description
pkmb	0.000e+0	60.99	pyruvate kinase PKM [Source:NCBI gene;Acc:10117042...	[more]
pkma	0.000e+0	57.17	pyruvate kinase PKM [Source:NCBI gene;Acc:10117074...	[more]
pkma	0.000e+0	57.17	pyruvate kinase PKM [Source:NCBI gene;Acc:10117074...	[more]
pkma	0.000e+0	57.55	pyruvate kinase PKM [Source:NCBI gene;Acc:10117074...	[more]
pklr	0.000e+0	53.47	pyruvate kinase PKM [Source:NCBI gene;Acc:10116118...	[more]

BLAST of Pyruvate kinase vs. Planmine SMEST
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST)
Total hits: 5


Match Name	E-value	Identity	Description
SMESG000017671.1	0.000e+0	99.64	SMESG000017671.1	[more]
SMESG000017671.1	0.000e+0	99.64	SMESG000017671.1	[more]
SMESG000017675.1	0.000e+0	66.06	SMESG000017675.1	[more]
SMESG000052083.1	0.000e+0	63.54	SMESG000052083.1	[more]
SMESG000006009.1	0.000e+0	62.08	SMESG000006009.1	[more]

Analyses

This transcript is derived from or has results from the following analyses


Analysis Name	Date Performed
Embryonic Stages	2016-07-25
Schmidtea mediterranea smed_20140614 BLASTX Human e!99	2016-08-08
Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99	2016-08-08
Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL	2020-05-01
Schmidtea mediterranea Sexual smed_20140614 transcriptome	2016-07-25
Schmidtea mediteranean smed_20140614 Interproscan	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST	2020-05-08

Sequences

The following sequences are available for this feature:

transcript sequence
protein sequence

transcript sequence

>SMED30012118 ID=SMED30012118|Name=Pyruvate kinase|organism=Schmidtea mediterranea sexual|type=transcript|length=2064bp
ATCGAAATTATTGTACAGAATGAAGAGATCATTTTACGTTTGAACGAGAT
AATGACAAATTGTTTGCAATTTTGAATGACTAGAAAATCATAATAAAAAC
ACAATTTAATTATCAAACCTTTTCACTCAATCAAATTATTTATTTGCTTT
TTCATATTGATGATGCAAGGAGCGAGATATTTTGAACAGTCGAATTACTT
TTTCCAAGAACGAAGAAGAGTTCATAAAGATTATGCTACGAATCTGGAAT
TAGTAGCCGACTTGAATATTGATTCTGATCCTGGAGTAATTCGGAATACC
GGAATAATATGTACACTTGGACCTGCGTGTGCTTCAGTGGCGATTCTCCA
CAAAATGATCGCGGCTGGAATGAATGTCGCGAGATTGAATTTCAGTCACG
GAACCCATGAAGATCATGCAAGATCTATTAAACTTTTGCGAGAAGCAATA
GCTACTCTCAAACCATATCGTTTTCCAATAGCAATAGCCCTTGATACGAA
AGGTCCAGAAATAAGAACCGGGTTAATAAATAATAATGAAACCGGAGAAG
TTCGCTTGAAAAAAGGAAATAATATTAAATTAGTTGTCAGTGAAGAATAT
TACCGTAAATGTGATGAAAATTTTATTTGGGTGGATTATAAAAGTATTTT
GAAATTACTAAAAGTTGGTAACCGAATATTTATTGATGACGGGTTAATTT
CTTTAATTGTTGAAGAAAAGGATTCTGAGTTTTTATTGTGCCGAATCGAA
AATGGAGGTATGCTAGGCTCTAGGAAAGGGGTGAACTTGCCGGGAGTTAA
TGTTGATTTACCAGCAGTTTCTGAAAAAGATAAAGAAGATCTGAAATTTG
CAGTTGAACAAAACGTTGATATTGTTTTTGCGTCATTTATCAGAAATGCG
GAATCTGTAAATATTATTCGGAAAATTCTTGGAGAAAAGGGGAAGCATAT
TCTCATAATTTCAAAGATCGAAAACCAAGAAGGAATGATTCAATTTGATG
AAATTCTTGAGGCTAGTGACGGAATTATGGTGGCCAGAGGTGATTTGGGA
ATTGAAATACCTCCTGAAAAAGTAATCTGTGCACAAAAAATGATGATTGG
CAAATGCAATGTAGCAGGAAAATCAGTGATTTGTGCAACTCATATGCTTG
AATCGATGATTACGAAATCTCGACCAACAAGAGCTGAAATTAGCGATGTA
GCTAATGCGGTCATCGACGGGTCAGATTGCGTGATGTTATCGGGTGAAAG
TGCTAAAGGTCGTTATCCAGTGGAAGCTGTGAAAATGATGCACACAATTT
GTCGTGAAGCTGAACATTTATTTTTTCAATCTAATTTCTTTGAGAGTATA
AAAGAAACAGTTAATTTGCCTACAGATCACACTCATAGTACCGCTATAGC
TGCAGTAGAAGCAGCTCAAAGATGCAATGCTGCAGTGATAATTGTTTTAA
CAACATCTGGAACTTCTGCAAAACTTATCGCCAAATACAGACCATCATGT
CCAATTCTTACTCTCACAAGAAACCCTATTACTGCTCGCCAAGCTCATCT
TTGGCGTGGTCTTCATCCAATTTTATTTTCAGATCCACGTAAGGAAGAAT
GGCCAAAAGACATGGACTTAAGAATTAACTTCTCAATTAATTATGCTTAT
CAACGGGGCTTTGTCAAGGCATTGGATATAATAATTATTGTCACTGGTTC
AAAGGCCGGTTCTGGCTCAACCAACACATTGCAAGTTGTTAAACTTGAGA
TTGACGAAAAAGAAGAAATTGGATTAAAGAAATATATATCTTATCCAACT
ATTAAGGAATTCGACGATTAGTTGGAAAGTTTCACAATTAGTTGAAAGTC
TTTTGACTTATTTATTTATAAATTACAAAAAATAATTTATATTATCAAAC
ATTTTTCACTATTGTAGATATGTTTTTTTAATTAATTGCTCGAAAATCAA
TACTAGACCACCGAAGAAAAGGCCAGCAATAATTTTCCCTTTTAAAGTTC
ATGGCTAGCTGAGCTGTAATTTCTTTATCAAATAGTTTTTCAAAGATGTA
GATTTTGTTCGTCC

protein sequence of SMED30012118-orf-1

>SMED30012118-orf-1 ID=SMED30012118-orf-1|Name=SMED30012118-orf-1|organism=Schmidtea mediterranea sexual|type=polypeptide|length=554bp
MMQGARYFEQSNYFFQERRRVHKDYATNLELVADLNIDSDPGVIRNTGII
CTLGPACASVAILHKMIAAGMNVARLNFSHGTHEDHARSIKLLREAIATL
KPYRFPIAIALDTKGPEIRTGLINNNETGEVRLKKGNNIKLVVSEEYYRK
CDENFIWVDYKSILKLLKVGNRIFIDDGLISLIVEEKDSEFLLCRIENGG
MLGSRKGVNLPGVNVDLPAVSEKDKEDLKFAVEQNVDIVFASFIRNAESV
NIIRKILGEKGKHILIISKIENQEGMIQFDEILEASDGIMVARGDLGIEI
PPEKVICAQKMMIGKCNVAGKSVICATHMLESMITKSRPTRAEISDVANA
VIDGSDCVMLSGESAKGRYPVEAVKMMHTICREAEHLFFQSNFFESIKET
VNLPTDHTHSTAIAAVEAAQRCNAAVIIVLTTSGTSAKLIAKYRPSCPIL
TLTRNPITARQAHLWRGLHPILFSDPRKEEWPKDMDLRINFSINYAYQRG
FVKALDIIIIVTGSKAGSGSTNTLQVVKLEIDEKEEIGLKKYISYPTIKE
FDD*

Annotated Terms

The following terms have been associated with this transcript:

Vocabulary: **Planarian Anatomy**
Term	Definition
PLANA:0000018	Category 4 cell
PLANA:0000020	protonephridia
PLANA:0000034	epidermis
PLANA:0002032	epidermal cell

Vocabulary: **INTERPRO**
Term	Definition
IPR036918	Pyrv_Knase_C_sf
IPR040442	Pyrv_Kinase-like_dom_sf
IPR001697	Pyr_Knase
IPR015795	Pyrv_Knase_C
IPR015794	Pyrv_Knase_a/b
IPR015793	Pyrv_Knase_brl
IPR015813	Pyrv/PenolPyrv_Kinase-like_dom
IPR015806	Pyrv_Knase_insert_dom_sf
IPR018209	Pyrv_Knase_AS
IPR011037	Pyrv_Knase-like_insert_dom_sf

Vocabulary: **molecular function**
Term	Definition
GO:0030955	potassium ion binding
GO:0004743	pyruvate kinase activity
GO:0000287	magnesium ion binding
GO:0003824	catalytic activity
GO:0016301	kinase activity
GO:0016740	transferase activity

Vocabulary: **biological process**
Term	Definition
GO:0006096	glycolytic process
GO:0016310	phosphorylation

InterPro

Analysis Name: Schmidtea mediteranean smed_20140614 Interproscan
Date Performed: 2020-05-01


IPR Term	IPR Description	Source	Source Term	Source Description	Alignment
IPR001697	Pyruvate kinase	PRINTS	PR01050	PYRUVTKNASE	coord: 343..361 score: 73.85 coord: 318..342 score: 66.58 coord: 362..378 score: 62.44 coord: 266..292 score: 64.5 coord: 293..317 score: 66.65 coord: 105..121 score: 70.32 coord: 236..250 score: 54.36
IPR001697	Pyruvate kinase	TIGRFAM	TIGR01064	TIGR01064	coord: 45..528 e-value: 5.0E-177 score: 587.1
IPR001697	Pyruvate kinase	PANTHER	PTHR11817	PYRUVATE KINASE	coord: 21..528
IPR001697	Pyruvate kinase	CDD	cd00288	Pyruvate_Kinase	coord: 44..527 e-value: 0.0 score: 687.125
IPR036918	Pyruvate kinase, C-terminal domain superfamily	GENE3D	G3DSA:3.40.1380.20		coord: 37..527 e-value: 2.8E-226 score: 753.6
IPR036918	Pyruvate kinase, C-terminal domain superfamily	SUPERFAMILY	SSF52935	PK C-terminal domain-like	coord: 372..529
IPR015793	Pyruvate kinase, barrel	PFAM	PF00224	PK	coord: 45..391 e-value: 4.4E-153 score: 509.3
IPR015795	Pyruvate kinase, C-terminal	PFAM	PF02887	PK_C	coord: 410..527 e-value: 1.1E-31 score: 109.5
IPR040442	Pyruvate kinase-like domain superfamily	GENE3D	G3DSA:3.20.20.60		coord: 45..385 e-value: 2.8E-226 score: 753.6
IPR015806	Pyruvate kinase, insert domain superfamily	GENE3D	G3DSA:2.40.33.10		coord: 117..219 e-value: 2.8E-226 score: 753.6
None	No IPR available	PANTHER	PTHR11817:SF83	PYRUVATE KINASE PKM	coord: 21..528
IPR018209	Pyruvate kinase, active site	PROSITE	PS00110	PYRUVATE_KINASE	coord: 264..276
IPR015813	Pyruvate/Phosphoenolpyruvate kinase-like domain superfamily	SUPERFAMILY	SSF51621	Phosphoenolpyruvate/pyruvate domain	coord: 31..390
IPR011037	Pyruvate kinase-like, insert domain superfamily	SUPERFAMILY	SSF50800	PK beta-barrel domain-like	coord: 116..217