tph
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Overview
Neoblast Clusters
Zeng et. al., 2018▻ Overview▻ Neoblast Population▻ Sub-lethal Irradiated Surviving X1 and X2 Cell Population
Overview
Single cell RNA-seq of pluripotent neoblasts and its early progeniesWe isolated X1 neoblasts cells enriched in high piwi-1 expression (Neoblast Population), and profiled ∼7,614 individual cells via scRNA-seq. Unsupervised analyses uncovered 12 distinct classes from 7,088 high-quality cells. We designated these classes Nb1 to Nb12 and ordered them based on high (Nb1) to low (Nb12) piwi-1 expression levels. We further defined groups of genes that best classified the cells parsed into 12 distinct cell clusters to generate a scaled expression heat map of discriminative gene sets for each cluster. Expression of each cluster’s gene signatures was validated using multiplex fluorescence in situ hybridization (FISH) co-stained with piwi-1 and largely confirmed the cell clusters revealed by scRNA-seq.We also tested sub-lethal irradiation exposure. To profile rare pluripotent stem cells (PSCs) and avoid interference from immediate progenitor cells, we determined a time point after sub-lethal irradiation (7 DPI) with minimal piwi-1+ cells, followed by isolation and single-cell RNA-seq of 1,200 individual cells derived from X1 (Piwi-1 high) and X2 (Piwi-1 low) cell populations (Sub-lethal Irradiated Surviving X1 and X2 Cell Population)Explore this single cell expression dataset with our NB Cluster Shiny App
Neoblast Population
Sub-lethal Irradiated Surviving X1 and X2 Cell Population
Embryonic Expression
Davies et. al., 2017
Hover the mouse over a column in the graph to view average RPKM values per sample. Embryonic Stages: Y: yolk. S2-S8: Stages 2-8. C4: asexual adult. SX: virgin, sexually mature adult. back to top Anatomical Expression
PAGE et. al., 2020SMED30012020 has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGEPAGE Curations: 26Note: Hover over icons to view figure legend
Homology
BLAST of tph vs. Ensembl Human
Match: TPH1 (tryptophan hydroxylase 1 [Source:HGNC Symbol;Acc:HGNC:12008]) HSP 1 Score: 584.334 bits (1505), Expect = 0.000e+0 Identity = 278/461 (60.30%), Postives = 352/461 (76.36%), Query Frame = 3
Query: 312 EENKTISTRRS-TSFIFGVNDNVKGLVRVLEIFEKFRVSVIHIETRKSLKNKSKFEIFIDVDCRKDEIKSLIECLQQKIDDDFHVQEVDMISSNINGIRIDTFDLAASEIGEQNIQLKNKKPGMTVDNLPWFPKYIKDLDKISNRVIMYGSELDADHPGFKDEVYRLRRNQFSEIAYSYKHGNPIPKIEYTNEEIKTWGNVYRELTKLYPTHACREFLQNLPLLQKYCGYREDNIPQLEDVSQFLKSRSGFTLRPVAGYLSSRDFLAGLAFRVFHCTQYIRHPSDPFYTPEPDCCHELMGHVPLLADSSFAQFSQEIGLASLGASEDEVQRLATCYFFTIEFGLCHQDGELRAYGAGLLSSIGELKHALSNESNIQKFDPKTVMEQECLVTTFQNAYFFTTSFEDAKDKMREFAKTIKKPFDVHYNPYTQMIETLDSTDSLTNVIDNIKGELATITNALRK 1691
+ENK S R S IF + + V GL++ L+IF++ V+++HIE+RKS + S+FEIF+D D ++++ +D FH ++ S+ N + ++ D N LK GM + +PWFPK I DLD +NRV+MYGSELDADHPGFKD VYR RR F+++A +YKHG+PIPK+E+T EEIKTWG V++EL KLYPTHACRE+L+NLPLL KYCGYREDNIPQLEDVS FLK R+GF++RPVAGYLS RDFL+GLAFRVFHCTQY+RH SDPFYTPEPD CHEL+GHVPLLA+ SFAQFSQEIGLASLGASE+ VQ+LATCYFFT+EFGLC QDG+LR +GAGLLSSI ELKHALS + ++ FDPK +QECL+TTFQ+ YF + SFEDAK+KMREF KTIK+PF V YNPYT+ I+ L T S+T+ ++ ++ +L +++AL K
Sbjct: 6 KENKDHSLERGRASLIFSLKNEVGGLIKALKIFQEKHVNLLHIESRKSKRRNSEFEIFVDCDINREQL-----------NDIFH-----LLKSHTNVLSVNLPD---------NFTLKED--GM--ETVPWFPKKISDLDHCANRVLMYGSELDADHPGFKDNVYRKRRKYFADLAMNYKHGDPIPKVEFTEEEIKTWGTVFQELNKLYPTHACREYLKNLPLLSKYCGYREDNIPQLEDVSNFLKERTGFSIRPVAGYLSPRDFLSGLAFRVFHCTQYVRHSSDPFYTPEPDTCHELLGHVPLLAEPSFAQFSQEIGLASLGASEEAVQKLATCYFFTVEFGLCKQDGQLRVFGAGLLSSISELKHALSGHAKVKPFDPKITCKQECLITTFQDVYFVSESFEDAKEKMREFTKTIKRPFGVKYNPYTRSIQILKDTKSITSAMNELQHDLDVVSDALAK 437
BLAST of tph vs. Ensembl Human
Match: TPH2 (tryptophan hydroxylase 2 [Source:HGNC Symbol;Acc:HGNC:20692]) HSP 1 Score: 573.163 bits (1476), Expect = 0.000e+0 Identity = 273/453 (60.26%), Postives = 346/453 (76.38%), Query Frame = 3
Query: 345 TSFIFGVNDNVKGLVRVLEIFEKFRVSVIHIETRKSLKNKSKFEIFIDVDCRKDEIKSLIECLQQKIDDDFHVQEVDMISSNINGIRIDTFDLAASEIGEQNIQLKNKKPGMTVDNLPWFPKYIKDLDKISNRVIMYGSELDADHPGFKDEVYRLRRNQFSEIAYSYKHGNPIPKIEYTNEEIKTWGNVYRELTKLYPTHACREFLQNLPLLQKYCGYREDNIPQLEDVSQFLKSRSGFTLRPVAGYLSSRDFLAGLAFRVFHCTQYIRHPSDPFYTPEPDCCHELMGHVPLLADSSFAQFSQEIGLASLGASEDEVQRLATCYFFTIEFGLCHQDGELRAYGAGLLSSIGELKHALSNESNIQKFDPKTVMEQECLVTTFQNAYFFTTSFEDAKDKMREFAKTIKKPFDVHYNPYTQMIETLDSTDSLTNVIDNIKGELATITNALRKFNIF 1703
T+ +F + + V GLV+ L +F++ RV+++HIE+RKS + S+ EIF+D +C K E LI+ L+ F V + +NI + ++ ++++PWFP+ I +LDK S+RV+MYGSELDADHPGFKD VYR RR F ++A YK+G PIP++EYT EE KTWG V+REL+KLYPTHACRE+L+N PLL KYCGYREDN+PQLEDVS FLK RSGFT+RPVAGYLS RDFLAGLA+RVFHCTQYIRH SDP YTPEPD CHEL+GHVPLLAD FAQFSQEIGLASLGAS+++VQ+LATCYFFTIEFGLC Q+G+LRAYGAGLLSSIGELKHALS+++ ++ FDPKT QECL+TTFQ AYF + SFE+AK+KMR+FAK+I +PF V++NPYTQ IE L T S+ NV+ +++ +L T+ +AL K N +
Sbjct: 64 TAVVFSLKNEVGGLVKALRLFQEKRVNMVHIESRKSRRRSSEVEIFVDCECGKTEFNELIQLLK------FQTTIVTLNPP-------------------ENIWTEEEE----LEDVPWFPRKISELDKCSHRVLMYGSELDADHPGFKDNVYRQRRKYFVDVAMGYKYGQPIPRVEYTEEETKTWGVVFRELSKLYPTHACREYLKNFPLLTKYCGYREDNVPQLEDVSMFLKERSGFTVRPVAGYLSPRDFLAGLAYRVFHCTQYIRHGSDPLYTPEPDTCHELLGHVPLLADPKFAQFSQEIGLASLGASDEDVQKLATCYFFTIEFGLCKQEGQLRAYGAGLLSSIGELKHALSDKACVKAFDPKTTCLQECLITTFQEAYFVSESFEEAKEKMRDFAKSITRPFSVYFNPYTQSIEILKDTRSIENVVQDLRSDLNTVCDALNKMNQY 487
BLAST of tph vs. Ensembl Human
Match: PAH (phenylalanine hydroxylase [Source:HGNC Symbol;Acc:HGNC:8582]) HSP 1 Score: 471.085 bits (1211), Expect = 8.809e-162 Identity = 230/450 (51.11%), Postives = 301/450 (66.89%), Query Frame = 3
Query: 342 STSFIFGVNDNVKGLVRVLEIFEKFRVSVIHIETRKSLKNKSKFEIFIDVDCRKDEIKSLIECLQQKIDDDFHVQEVDMISSNINGIRIDTFDLAASEIGEQNIQLKNKKPGMTVDNLPWFPKYIKDLDKISNRVIMYGSELDADHPGFKDEVYRLRRNQFSEIAYSYKHGNPIPKIEYTNEEIKTWGNVYRELTKLYPTHACREFLQNLPLLQKYCGYREDNIPQLEDVSQFLKSRSGFTLRPVAGYLSSRDFLAGLAFRVFHCTQYIRHPSDPFYTPEPDCCHELMGHVPLLADSSFAQFSQEIGLASLGASEDEVQRLATCYFFTIEFGLCHQDGELRAYGAGLLSSIGELKHALSNESNIQKFDPKTVMEQECLVTTFQNAYFFTTSFEDAKDKMREFAKTIKKPFDVHYNPYTQMIETLDSTDSLTNVIDNIKGELATITNALRK 1691
+ S IF + + V L +VL +FE+ V++ HIE+R S K ++E F +D R + + N I+I D+ A+ + KK D +PWFP+ I++LD+ +N+++ YG+ELDADHPGFKD VYR RR QF++IAY+Y+HG PIP++EY EE KTWG V++ L LY THAC E+ PLL+KYCG+ EDNIPQLEDVSQFL++ +GF LRPVAG LSSRDFL GLAFRVFHCTQYIRH S P YTPEPD CHEL+GHVPL +D SFAQFSQEIGLASLGA ++ +++LAT Y+FT+EFGLC Q ++AYGAGLLSS GEL++ LS + + + + Q VT FQ Y+ SF DAK+K+R FA TI +PF V Y+PYTQ IE LD+T L + D+I E+ + +AL+K
Sbjct: 29 AISLIFSLKEEVGALAKVLRLFEENDVNLTHIESRPSRLKKDEYEFFTHLDKRS-------------------------LPALTNIIKILRHDIGATV---HELSRDKKK-----DTVPWFPRTIQELDRFANQILSYGAELDADHPGFKDPVYRARRKQFADIAYNYRHGQPIPRVEYMEEEKKTWGTVFKTLKSLYKTHACYEYNHIFPLLEKYCGFHEDNIPQLEDVSQFLQTCTGFRLRPVAGLLSSRDFLGGLAFRVFHCTQYIRHGSKPMYTPEPDICHELLGHVPLFSDRSFAQFSQEIGLASLGAPDEYIEKLATIYWFTVEFGLCKQGDSIKAYGAGLLSSFGELQYCLSEKPKLLPLELEKTAIQNYTVTEFQPLYYVAESFNDAKEKVRNFAATIPRPFSVRYDPYTQRIEVLDNTQQLKILADSINSEIGILCSALQK 445
BLAST of tph vs. Ensembl Human
Match: PAH (phenylalanine hydroxylase [Source:HGNC Symbol;Acc:HGNC:8582]) HSP 1 Score: 470.7 bits (1210), Expect = 1.387e-161 Identity = 230/450 (51.11%), Postives = 301/450 (66.89%), Query Frame = 3
Query: 342 STSFIFGVNDNVKGLVRVLEIFEKFRVSVIHIETRKSLKNKSKFEIFIDVDCRKDEIKSLIECLQQKIDDDFHVQEVDMISSNINGIRIDTFDLAASEIGEQNIQLKNKKPGMTVDNLPWFPKYIKDLDKISNRVIMYGSELDADHPGFKDEVYRLRRNQFSEIAYSYKHGNPIPKIEYTNEEIKTWGNVYRELTKLYPTHACREFLQNLPLLQKYCGYREDNIPQLEDVSQFLKSRSGFTLRPVAGYLSSRDFLAGLAFRVFHCTQYIRHPSDPFYTPEPDCCHELMGHVPLLADSSFAQFSQEIGLASLGASEDEVQRLATCYFFTIEFGLCHQDGELRAYGAGLLSSIGELKHALSNESNIQKFDPKTVMEQECLVTTFQNAYFFTTSFEDAKDKMREFAKTIKKPFDVHYNPYTQMIETLDSTDSLTNVIDNIKGELATITNALRK 1691
+ S IF + + V L +VL +FE+ V++ HIE+R S K ++E F +D R + + N I+I D+ A+ + KK D +PWFP+ I++LD+ +N+++ YG+ELDADHPGFKD VYR RR QF++IAY+Y+HG PIP++EY EE KTWG V++ L LY THAC E+ PLL+KYCG+ EDNIPQLEDVSQFL++ +GF LRPVAG LSSRDFL GLAFRVFHCTQYIRH S P YTPEPD CHEL+GHVPL +D SFAQFSQEIGLASLGA ++ +++LAT Y+FT+EFGLC Q ++AYGAGLLSS GEL++ LS + + + + Q VT FQ Y+ SF DAK+K+R FA TI +PF V Y+PYTQ IE LD+T L + D+I E+ + +AL+K
Sbjct: 34 AISLIFSLKEEVGALAKVLRLFEENDVNLTHIESRPSRLKKDEYEFFTHLDKRS-------------------------LPALTNIIKILRHDIGATV---HELSRDKKK-----DTVPWFPRTIQELDRFANQILSYGAELDADHPGFKDPVYRARRKQFADIAYNYRHGQPIPRVEYMEEEKKTWGTVFKTLKSLYKTHACYEYNHIFPLLEKYCGFHEDNIPQLEDVSQFLQTCTGFRLRPVAGLLSSRDFLGGLAFRVFHCTQYIRHGSKPMYTPEPDICHELLGHVPLFSDRSFAQFSQEIGLASLGAPDEYIEKLATIYWFTVEFGLCKQGDSIKAYGAGLLSSFGELQYCLSEKPKLLPLELEKTAIQNYTVTEFQPLYYVAESFNDAKEKVRNFAATIPRPFSVRYDPYTQRIEVLDNTQQLKILADSINSEIGILCSALQK 450
BLAST of tph vs. Ensembl Human
Match: TH (tyrosine hydroxylase [Source:HGNC Symbol;Acc:HGNC:11782]) HSP 1 Score: 448.358 bits (1152), Expect = 3.740e-152 Identity = 211/438 (48.17%), Postives = 292/438 (66.67%), Query Frame = 3
Query: 381 GLVRVLEIFEKFRVSVIHIETRKSLKNKS---KFEIFIDVDCRKDEIKSLIECLQQKIDDDFHVQEVDMISSNINGIRIDTFDLAASEIGEQNIQLKNKKPGMTVDNLPWFPKYIKDLDKISNRVIMYGSELDADHPGFKDEVYRLRRNQFSEIAYSYKHGNPIPKIEYTNEEIKTWGNVYRELTKLYPTHACREFLQNLPLLQKYCGYREDNIPQLEDVSQFLKSRSGFTLRPVAGYLSSRDFLAGLAFRVFHCTQYIRHPSDPFYTPEPDCCHELMGHVPLLADSSFAQFSQEIGLASLGASEDEVQRLATCYFFTIEFGLCHQDGELRAYGAGLLSSIGELKHALSNESNIQKFDPKTVMEQECLVTTFQNAYFFTTSFEDAKDKMREFAKTIKKPFDVHYNPYTQMIETLDSTDSLTNVIDNIKGELATITNAL 1685
L R +++FE F + H+ETR + + ++ E F+ ++ R+ ++ +L+ ++Q +S ++ S G + +PWFP+ + +LDK + V + +LD DHPGF D+VYR RR +EIA+ Y+HG+PIP++EYT EEI TW VY L LY THAC E L+ LL+++ GYREDNIPQLEDVS+FLK R+GF LRPVAG LS+RDFLA LAFRVF CTQYIRH S P ++PEPDCCHEL+GHVP+LAD +FAQFSQ+IGLASLGAS++E+++L+T Y+FT+EFGLC Q+GE++AYGAGLLSS GEL H LS E I+ FDP+ Q T+Q+ YF + SF DAKDK+R +A I++PF V ++PYT I+ LDS ++ ++ ++ EL T+ +AL
Sbjct: 95 ALSRAVKVFETFEAKIHHLETRPAQRPRAGGPHLEYFVRLEVRRGDLAALLSGVRQ-------------VSEDVR-----------SPAGPK---------------VPWFPRKVSELDKCHHLVTKFDPDLDLDHPGFSDQVYRQRRKLIAEIAFQYRHGDPIPRVEYTAEEIATWKEVYTTLKGLYATHACGEHLEAFALLERFSGYREDNIPQLEDVSRFLKERTGFQLRPVAGLLSARDFLASLAFRVFQCTQYIRHASSPMHSPEPDCCHELLGHVPMLADRTFAQFSQDIGLASLGASDEEIEKLSTLYWFTVEFGLCKQNGEVKAYGAGLLSSYGELLHCLSEEPEIRAFDPEAAAVQPYQDQTYQSVYFVSESFSDAKDKLRSYASRIQRPFSVKFDPYTLAIDVLDSPQAVRRSLEGVQDELDTLAHAL 493
BLAST of tph vs. Ensembl Celegans
Match: pah-1 (Phenylalanine-4-hydroxylase [Source:UniProtKB/Swiss-Prot;Acc:P90925]) HSP 1 Score: 451.44 bits (1160), Expect = 1.669e-154 Identity = 221/453 (48.79%), Postives = 301/453 (66.45%), Query Frame = 3
Query: 345 TSFIFGVNDNVKGLVRVLEIFEKFRVSVIHIETRKSLKNKSKFEIFIDVDCRKD--EIKSLIECLQQKIDDDFHVQEVDMISSNINGIRIDTFDLAASEIGEQNIQLKNKKPGMTVDNLPWFPKYIKDLDKISNRVIMYGSELDADHPGFKDEVYRLRRNQFSEIAYSYKHGNPIPKIEYTNEEIKTWGNVYRELTKLYPTHACREFLQNLPLLQKYCGYREDNIPQLEDVSQFLKSRSGFTLRPVAGYLSSRDFLAGLAFRVFHCTQYIRHPSDPFYTPEPDCCHELMGHVPLLADSSFAQFSQEIGLASLGASEDEVQRLATCYFFTIEFGLCHQDGELRAYGAGLLSSIGELKHALSNESNIQKFDPKTVMEQECLVTTFQNAYFFTTSFEDAKDKMREFAKTIKKPFDVHYNPYTQMIETLDSTDSLTNVIDNIKGELATITNALRKFN 1697
T+ +F + + L L++F+ V++ HIE+R S ++ +E+ ++ +D +I+ +IE QQK + VQ+ + KNK+ D++PWFP+ I D+D+ +NR++ YG+ELDADHPGFKD YR RR F++IA+++KHG+ IP I YT+EEI TW VY ELT +YP +AC+EF PLLQ+ CG+ D IPQL+DVS FLK +G+T+RPVAG LSSRDFLAGLAFRVFH TQYIRH S P YTPEPD CHEL+GHVPL AD FAQFSQEIGLASLGA +D +++LAT Y+FTIEFG+C QDGE +AYGAGLLSS GEL++ALS++ + FDP + +T +Q YF SF AK+K++ +A TI +PF + YN YTQ +E LD +L + +I+ +++T+ AL K N
Sbjct: 26 TTIVFTLREKAGALAETLKLFQAHDVNLSHIESRPSKTHEGCYEVLVEFAEAEDHRKIEGVIEHFQQKAEKKVLVQDWNT---------------------------KNKQ---NKDSVPWFPQKINDIDQFANRILSYGAELDADHPGFKDMTYRERRKFFADIAFNFKHGDKIPTITYTDEEIATWRTVYNELTVMYPKNACQEFNYIFPLLQQNCGFGPDRIPQLQDVSDFLKDCTGYTIRPVAGLLSSRDFLAGLAFRVFHSTQYIRHHSAPKYTPEPDICHELLGHVPLFADVEFAQFSQEIGLASLGAPDDVIEKLATLYWFTIEFGICQQDGEKKAYGAGLLSSFGELQYALSDKPEVVDFDPAVCCVTKYPITEYQPKYFLAESFASAKNKLKSWAATINRPFQIRYNAYTQRVEILDKVAALQRLARDIRSDISTLEEALGKVN 448
BLAST of tph vs. Ensembl Celegans
Match: pah-1 (Phenylalanine-4-hydroxylase [Source:UniProtKB/Swiss-Prot;Acc:P90925]) HSP 1 Score: 451.44 bits (1160), Expect = 2.062e-154 Identity = 221/453 (48.79%), Postives = 301/453 (66.45%), Query Frame = 3
Query: 345 TSFIFGVNDNVKGLVRVLEIFEKFRVSVIHIETRKSLKNKSKFEIFIDVDCRKD--EIKSLIECLQQKIDDDFHVQEVDMISSNINGIRIDTFDLAASEIGEQNIQLKNKKPGMTVDNLPWFPKYIKDLDKISNRVIMYGSELDADHPGFKDEVYRLRRNQFSEIAYSYKHGNPIPKIEYTNEEIKTWGNVYRELTKLYPTHACREFLQNLPLLQKYCGYREDNIPQLEDVSQFLKSRSGFTLRPVAGYLSSRDFLAGLAFRVFHCTQYIRHPSDPFYTPEPDCCHELMGHVPLLADSSFAQFSQEIGLASLGASEDEVQRLATCYFFTIEFGLCHQDGELRAYGAGLLSSIGELKHALSNESNIQKFDPKTVMEQECLVTTFQNAYFFTTSFEDAKDKMREFAKTIKKPFDVHYNPYTQMIETLDSTDSLTNVIDNIKGELATITNALRKFN 1697
T+ +F + + L L++F+ V++ HIE+R S ++ +E+ ++ +D +I+ +IE QQK A ++ Q+ KNK+ D++PWFP+ I D+D+ +NR++ YG+ELDADHPGFKD YR RR F++IA+++KHG+ IP I YT+EEI TW VY ELT +YP +AC+EF PLLQ+ CG+ D IPQL+DVS FLK +G+T+RPVAG LSSRDFLAGLAFRVFH TQYIRH S P YTPEPD CHEL+GHVPL AD FAQFSQEIGLASLGA +D +++LAT Y+FTIEFG+C QDGE +AYGAGLLSS GEL++ALS++ + FDP + +T +Q YF SF AK+K++ +A TI +PF + YN YTQ +E LD +L + +I+ +++T+ AL K N
Sbjct: 30 TTIVFTLREKAGALAETLKLFQAHDVNLSHIESRPSKTHEGCYEVLVEFAEAEDHRKIEGVIEHFQQK---------------------------AEKKVLVQDWNTKNKQ---NKDSVPWFPQKINDIDQFANRILSYGAELDADHPGFKDMTYRERRKFFADIAFNFKHGDKIPTITYTDEEIATWRTVYNELTVMYPKNACQEFNYIFPLLQQNCGFGPDRIPQLQDVSDFLKDCTGYTIRPVAGLLSSRDFLAGLAFRVFHSTQYIRHHSAPKYTPEPDICHELLGHVPLFADVEFAQFSQEIGLASLGAPDDVIEKLATLYWFTIEFGICQQDGEKKAYGAGLLSSFGELQYALSDKPEVVDFDPAVCCVTKYPITEYQPKYFLAESFASAKNKLKSWAATINRPFQIRYNAYTQRVEILDKVAALQRLARDIRSDISTLEEALGKVN 452
BLAST of tph vs. Ensembl Celegans
Match: tph-1 (TryPtophan Hydroxylase [Source:UniProtKB/TrEMBL;Acc:Q2V4U7]) HSP 1 Score: 439.499 bits (1129), Expect = 3.156e-150 Identity = 204/379 (53.83%), Postives = 275/379 (72.56%), Query Frame = 3
Query: 600 IRIDTFDL--AASEIGEQNIQLKNKKPGM--TVDNLPWFPKYIKDLDKISNRVIMYGSELDADHPGFKDEVYRLRRNQFSEIAYSYKHGNPIPKIEYTNEEIKTWGNVYRELTKLYPTHACREFLQNLPLLQKYCGYREDNIPQLEDVSQFLKSRSGFTLRPVAGYLSSRDFLAGLAFRVFHCTQYIRHPSDPFYTPEPDCCHELMGHVPLLADSSFAQFSQEIGLASLGASEDEVQRLATCYFFTIEFGLCHQDG-------------ELRAYGAGLLSSIGELKHALSNESNIQKFDPKTVMEQECLVTTFQNAYFFTTSFEDAKDKMREFAKTIKKPFDVHYNPYTQMIETLDSTDSLTNVIDNIKGELATITNAL 1685
+R++ D+ +S I I+ + +PG WFPK I DLD + RVIMYG+ LDADHPGFKD YR RR F+E+A +YKHG PIP+ EYT+ E KTWG +YR+L +L+ HAC++FL N LL+++CGY E+NIPQLED+ +FLK+++GF +RPVAGYLS+RDFLAGLA+RVF CTQY+RH +DPFYTPEPD HELMGH+ L AD FAQFSQEIGLASLGASE+++++LAT YFF+IEFGL D + YGAGLLSS GEL+HA+ + I +FDP V+EQECL+TTFQ+AYF+T +FE+A+ K+R F +K+PF V YNPYT+ +E L+++ S+ +++++ ++ + AL
Sbjct: 47 MRLNGLDVHEVSSTIRPTAIKEQYTEPGSDDATTGSEWFPKSIYDLDICAKRVIMYGAGLDADHPGFKDTEYRQRRMMFAELALNYKHGEPIPRTEYTSSERKTWGIIYRKLRELHKKHACKQFLDNFELLERHCGYSENNIPQLEDICKFLKAKTGFRVRPVAGYLSARDFLAGLAYRVFFCTQYVRHHADPFYTPEPDTVHELMGHMALFADPDFAQFSQEIGLASLGASEEDLKKLATLYFFSIEFGLSSDDAADSPVKENGSNHERFKVYGAGLLSSAGELQHAVEGSATIIRFDPDRVVEQECLITTFQSAYFYTRNFEEAQQKLRMFTNNMKRPFIVRYNPYTESVEVLNNSRSIMLAVNSLRSDINLLAGAL 425
BLAST of tph vs. Ensembl Celegans
Match: tph-1 (TryPtophan Hydroxylase [Source:UniProtKB/TrEMBL;Acc:Q2V4U7]) HSP 1 Score: 442.58 bits (1137), Expect = 8.089e-150 Identity = 204/379 (53.83%), Postives = 275/379 (72.56%), Query Frame = 3
Query: 600 IRIDTFDL--AASEIGEQNIQLKNKKPGM--TVDNLPWFPKYIKDLDKISNRVIMYGSELDADHPGFKDEVYRLRRNQFSEIAYSYKHGNPIPKIEYTNEEIKTWGNVYRELTKLYPTHACREFLQNLPLLQKYCGYREDNIPQLEDVSQFLKSRSGFTLRPVAGYLSSRDFLAGLAFRVFHCTQYIRHPSDPFYTPEPDCCHELMGHVPLLADSSFAQFSQEIGLASLGASEDEVQRLATCYFFTIEFGLCHQDG-------------ELRAYGAGLLSSIGELKHALSNESNIQKFDPKTVMEQECLVTTFQNAYFFTTSFEDAKDKMREFAKTIKKPFDVHYNPYTQMIETLDSTDSLTNVIDNIKGELATITNAL 1685
+R++ D+ +S I I+ + +PG WFPK I DLD + RVIMYG+ LDADHPGFKD YR RR F+E+A +YKHG PIP+ EYT+ E KTWG +YR+L +L+ HAC++FL N LL+++CGY E+NIPQLED+ +FLK+++GF +RPVAGYLS+RDFLAGLA+RVF CTQY+RH +DPFYTPEPD HELMGH+ L AD FAQFSQEIGLASLGASE+++++LAT YFF+IEFGL D + YGAGLLSS GEL+HA+ + I +FDP V+EQECL+TTFQ+AYF+T +FE+A+ K+R F +K+PF V YNPYT+ +E L+++ S+ +++++ ++ + AL
Sbjct: 150 MRLNGLDVHEVSSTIRPTAIKEQYTEPGSDDATTGSEWFPKSIYDLDICAKRVIMYGAGLDADHPGFKDTEYRQRRMMFAELALNYKHGEPIPRTEYTSSERKTWGIIYRKLRELHKKHACKQFLDNFELLERHCGYSENNIPQLEDICKFLKAKTGFRVRPVAGYLSARDFLAGLAYRVFFCTQYVRHHADPFYTPEPDTVHELMGHMALFADPDFAQFSQEIGLASLGASEEDLKKLATLYFFSIEFGLSSDDAADSPVKENGSNHERFKVYGAGLLSSAGELQHAVEGSATIIRFDPDRVVEQECLITTFQSAYFYTRNFEEAQQKLRMFTNNMKRPFIVRYNPYTESVEVLNNSRSIMLAVNSLRSDINLLAGAL 528
BLAST of tph vs. Ensembl Celegans
Match: cat-2 (Tyrosine 3-monooxygenase [Source:UniProtKB/Swiss-Prot;Acc:P90986]) HSP 1 Score: 314.309 bits (804), Expect = 4.756e-101 Identity = 161/436 (36.93%), Postives = 247/436 (56.65%), Query Frame = 3
Query: 393 VLEIFEKFRVSVIHIETRKSLKNKSKFEIFIDVDCRKDEIKSLIECLQQKIDDDFHVQEVDMISSNINGIRIDTFDLAASEIGEQNIQLKNKKPGMTVDNLPWFPKYIKDLDKISNRVIMYGSELDADHPGFKDEVYRLRRNQFSEIAYSYKHGNPIPKIEYTNEEIKTWGNVYRELTKLYPTHACREFLQNLPLLQKYCGYREDNIPQLEDVSQFLKSRSGFTLRPVAGYLSSRDFLAGLAFRVFHCTQYIRHPSDPFYTPEPDCCHELMGHVPLLADSSFAQFSQEIGLASLGASEDEVQRLATCYFFTIEFGLCHQDGELRAYGAGLLSSIGELKHALSNESNIQKFDPKTVMEQECLVTTFQNAYFFTTSFEDAKDKMREFAKTIKKPFDVHYNPYTQMIETLDSTDSLTNVIDNIKGELATITNALRKFNI 1700
+L+ +V + H+ETR N++ ++ + K+++ E L Q N + + F + A ++ ++ Q + WFP++I +LD+ S + Y D HPG D Y RR ++ A +K G+ I ++YT EE TW VY +L L+ +H C + QNL +LQ+ D IPQ+ DV++FL+ ++GF LRP +G LS+RDFLA LAFRVF T Y+RH P ++PEPD HEL+GHVP+ +D AQ SQ+IGL SLGAS++ +++L+T Y+F +EFGLC +DG+L+A GAGLLS+ GEL HA S+ + FDP Q+ +Q YF S DA K+R++A ++ +PF V Y+P+T+ IE ++S+ L + +L+ IT+A + I
Sbjct: 47 ILQNMSSAKVQICHVETRG---NEASHDVLLACKATKNQLIHSAELLTQ------------------NHVALTKFSIFAKKLSDEKNQSQ-----------IWFPRHISELDQCSKCITKYEPTTDPRHPGHGDVAYIARRKFLNDQALEFKFGDEIGYVDYTEEEHATWKAVYEKLGDLHLSHTCAVYRQNLKILQEEKVLTADRIPQIRDVNKFLQKKTGFELRPCSGLLSARDFLASLAFRVFQTTTYLRHHKSPHHSPEPDLIHELLGHVPMFSDPLLAQMSQDIGLMSLGASDEHIEKLSTVYWFIVEFGLCKEDGKLKAIGAGLLSAYGELMHACSDAPEHKDFDPAVTAVQKYEDDDYQPLYFVADSIHDALAKLRKYASSMDRPFSVVYDPFTKSIEAIESSADLEKAFSRLSNDLSAITHAADRMKI 450
BLAST of tph vs. Ensembl Fly
Match: Trh (gene:FBgn0035187 transcript:FBtr0072638) HSP 1 Score: 518.85 bits (1335), Expect = 2.823e-179 Identity = 238/452 (52.65%), Postives = 328/452 (72.57%), Query Frame = 3
Query: 348 SFIFGVNDNVKGLVRVLEIFEKFRVSVIHIETRKSLKNKSKFEIFIDVDCRKDEIKSLIECLQQKIDDDFHVQEVDMISSNINGI-RIDTFDLAASEIGEQNIQLKNKKPGMTVDNLPWFPKYIKDLDKISNRVIMYGSELDADHPGFKDEVYRLRRNQFSEIAYSYKHGNPIPKIEYTNEEIKTWGNVYRELTKLYPTHACREFLQNLPLLQKYCGYREDNIPQLEDVSQFLKSRSGFTLRPVAGYLSSRDFLAGLAFRVFHCTQYIRHPSDPFYTPEPDCCHELMGHVPLLADSSFAQFSQEIGLASLGASEDEVQRLATCYFFTIEFGLCHQ-DGELRAYGAGLLSSIGELKHALSNESNIQKFDPKTVMEQECLVTTFQNAYFFTTSFEDAKDKMREFAKTIKKPFDVHYNPYTQMIETLDSTDSLTNVIDNIKGELATITNALRKFN 1697
S IF + + V L R L++F++ ++V+H+E ++ ++ +DV+C + + +++ L ++ V V+ S N G+ R + +S ++ WFP+ I DLDK N V+MYGSELDADHPGFKD VYR RR QFS IA ++KHGNPIP+++YT EE+KTWG V+ EL +LY HA E++ N P L+KYCGYREDN+PQL+DVS +LK ++GF LRPVAGYLS RDFL+GLAFRVFHCTQYIRH SDPFYTPEPDCCHEL+GH+PLLA+SSFAQFSQEIGLASLGAS+ ++++LAT YFFT+EFGLC Q D + YGAGLLSS+ EL+HA++ E+ I+KFDP+ +QEC++T++QNAY++T SFE+AK++MR FA++I++PF V YNPYT +E L + +T V+ ++G+L+ + +ALRK +
Sbjct: 80 SIIFTLRNQVGNLARALQVFQELGINVLHLELSPLEMATNQADVLVDVECDQRRLDQVVKMLNRE------VASVNYTSVNTQGLARAPSLSACSS---------------FDFGDMVWFPRKISDLDKAQN-VLMYGSELDADHPGFKDPVYRKRREQFSAIANNFKHGNPIPRVQYTPEEVKTWGTVFLELHRLYVLHAVPEYMDNWPELEKYCGYREDNVPQLQDVSVYLKRKTGFQLRPVAGYLSPRDFLSGLAFRVFHCTQYIRHSSDPFYTPEPDCCHELLGHMPLLANSSFAQFSQEIGLASLGASDADIEKLATLYFFTVEFGLCKQADSTFKVYGAGLLSSVAELQHAITAENKIKKFDPEVTCQQECIITSYQNAYYYTDSFEEAKEQMRAFAESIQRPFGVRYNPYTMSVEVLSNAKKITAVVSELRGDLSIVCSALRKIS 509
BLAST of tph vs. Ensembl Fly
Match: Hn (gene:FBgn0001208 transcript:FBtr0100225) HSP 1 Score: 471.085 bits (1211), Expect = 3.744e-162 Identity = 230/465 (49.46%), Postives = 309/465 (66.45%), Query Frame = 3
Query: 315 ENKTISTRRSTSFIFGVNDNV---KGLVRVLEIFEKFRVSVIHIETRKSLKNKSKFEIFIDVDCRKDEIKSLIECLQQKIDDDFHVQEVDMISSNINGIRIDTFDLAASEIGEQNIQLKNKKPGMTVDNLPWFPKYIKDLDKISNRVIMYGSELDADHPGFKDEVYRLRRNQFSEIAYSYKHGNPIPKIEYTNEEIKTWGNVYRELTKLYPTHACREFLQNLPLLQKYCGYREDNIPQLEDVSQFLKSRSGFTLRPVAGYLSSRDFLAGLAFRVFHCTQYIRHPSDPFYTPEPDCCHELMGHVPLLADSSFAQFSQEIGLASLGASEDEVQRLATCYFFTIEFGLCHQDGELRAYGAGLLSSIGELKHALSNESNIQKFDPKTVMEQECLVTTFQNAYFFTTSFEDAKDKMREFAKTIKKPFDVHYNPYTQMIETLDSTDSLTNVIDNIKGELATITNALRKFNI 1700
E I R+T +F D+ L +L IF+K ++++HIE+R SL+ +E F++ D + + IE ++++ S N I D D A + +PWFP+ I+DLD+ +N+++ YGSELDADHPGF D YR RR F++IAY+YKHG P+P ++YT EEI+TWG ++R LTKLY THACRE+ PLL CG+REDNIPQLEDVS FL+ +GFTLRPVAG LSSRDFLAGLAFRVFH TQYIRHPS P YTPEPD CHELMGHVPL AD +FAQFSQEIGLASLGA +D +++L+T ++FT+E+G+C Q+GEL+AYGAGLLSS GEL++ L+++ ++ F+P+ + +T FQ Y+ SFE AK+K +FA +I +PF V YN YTQ +E LDS ++N++DNI E + NA+ K +
Sbjct: 17 EGVDIKEARNTCLLFSPKDSSLSSGALANILAIFKKHDINLVHIESRSSLRVPG-YEFFVEADGKSGALGKAIEDVKEQ-------------CSYFNIISRDYKDNATA--------------------VPWFPRRIRDLDRFANQILSYGSELDADHPGFTDPEYRKRRKYFADIAYNYKHGEPLPHVDYTKEEIETWGIIFRNLTKLYKTHACREYNHVFPLLVDNCGFREDNIPQLEDVSNFLRDCTGFTLRPVAGLLSSRDFLAGLAFRVFHSTQYIRHPSKPMYTPEPDVCHELMGHVPLFADPAFAQFSQEIGLASLGAPDDYIEKLSTIFWFTVEYGVCRQEGELKAYGAGLLSSYGELEYCLTDKPQLKDFEPEVTGVTKYPITQFQPLYYVADSFETAKEKTIKFANSIPRPFGVRYNAYTQSVEVLDSKPQISNLMDNINSEFQILQNAVAKLRV 447
BLAST of tph vs. Ensembl Fly
Match: Hn (gene:FBgn0001208 transcript:FBtr0334645) HSP 1 Score: 471.085 bits (1211), Expect = 4.593e-162 Identity = 230/465 (49.46%), Postives = 309/465 (66.45%), Query Frame = 3
Query: 315 ENKTISTRRSTSFIFGVNDNV---KGLVRVLEIFEKFRVSVIHIETRKSLKNKSKFEIFIDVDCRKDEIKSLIECLQQKIDDDFHVQEVDMISSNINGIRIDTFDLAASEIGEQNIQLKNKKPGMTVDNLPWFPKYIKDLDKISNRVIMYGSELDADHPGFKDEVYRLRRNQFSEIAYSYKHGNPIPKIEYTNEEIKTWGNVYRELTKLYPTHACREFLQNLPLLQKYCGYREDNIPQLEDVSQFLKSRSGFTLRPVAGYLSSRDFLAGLAFRVFHCTQYIRHPSDPFYTPEPDCCHELMGHVPLLADSSFAQFSQEIGLASLGASEDEVQRLATCYFFTIEFGLCHQDGELRAYGAGLLSSIGELKHALSNESNIQKFDPKTVMEQECLVTTFQNAYFFTTSFEDAKDKMREFAKTIKKPFDVHYNPYTQMIETLDSTDSLTNVIDNIKGELATITNALRKFNI 1700
E I R+T +F D+ L +L IF+K ++++HIE+R SL+ +E F++ D + + IE ++++ S N I D D A + +PWFP+ I+DLD+ +N+++ YGSELDADHPGF D YR RR F++IAY+YKHG P+P ++YT EEI+TWG ++R LTKLY THACRE+ PLL CG+REDNIPQLEDVS FL+ +GFTLRPVAG LSSRDFLAGLAFRVFH TQYIRHPS P YTPEPD CHELMGHVPL AD +FAQFSQEIGLASLGA +D +++L+T ++FT+E+G+C Q+GEL+AYGAGLLSS GEL++ L+++ ++ F+P+ + +T FQ Y+ SFE AK+K +FA +I +PF V YN YTQ +E LDS ++N++DNI E + NA+ K +
Sbjct: 22 EGVDIKEARNTCLLFSPKDSSLSSGALANILAIFKKHDINLVHIESRSSLRVPG-YEFFVEADGKSGALGKAIEDVKEQ-------------CSYFNIISRDYKDNATA--------------------VPWFPRRIRDLDRFANQILSYGSELDADHPGFTDPEYRKRRKYFADIAYNYKHGEPLPHVDYTKEEIETWGIIFRNLTKLYKTHACREYNHVFPLLVDNCGFREDNIPQLEDVSNFLRDCTGFTLRPVAGLLSSRDFLAGLAFRVFHSTQYIRHPSKPMYTPEPDVCHELMGHVPLFADPAFAQFSQEIGLASLGAPDDYIEKLSTIFWFTVEYGVCRQEGELKAYGAGLLSSYGELEYCLTDKPQLKDFEPEVTGVTKYPITQFQPLYYVADSFETAKEKTIKFANSIPRPFGVRYNAYTQSVEVLDSKPQISNLMDNINSEFQILQNAVAKLRV 452
BLAST of tph vs. Ensembl Fly
Match: Hn (gene:FBgn0001208 transcript:FBtr0076811) HSP 1 Score: 471.085 bits (1211), Expect = 4.593e-162 Identity = 230/465 (49.46%), Postives = 309/465 (66.45%), Query Frame = 3
Query: 315 ENKTISTRRSTSFIFGVNDNV---KGLVRVLEIFEKFRVSVIHIETRKSLKNKSKFEIFIDVDCRKDEIKSLIECLQQKIDDDFHVQEVDMISSNINGIRIDTFDLAASEIGEQNIQLKNKKPGMTVDNLPWFPKYIKDLDKISNRVIMYGSELDADHPGFKDEVYRLRRNQFSEIAYSYKHGNPIPKIEYTNEEIKTWGNVYRELTKLYPTHACREFLQNLPLLQKYCGYREDNIPQLEDVSQFLKSRSGFTLRPVAGYLSSRDFLAGLAFRVFHCTQYIRHPSDPFYTPEPDCCHELMGHVPLLADSSFAQFSQEIGLASLGASEDEVQRLATCYFFTIEFGLCHQDGELRAYGAGLLSSIGELKHALSNESNIQKFDPKTVMEQECLVTTFQNAYFFTTSFEDAKDKMREFAKTIKKPFDVHYNPYTQMIETLDSTDSLTNVIDNIKGELATITNALRKFNI 1700
E I R+T +F D+ L +L IF+K ++++HIE+R SL+ +E F++ D + + IE ++++ S N I D D A + +PWFP+ I+DLD+ +N+++ YGSELDADHPGF D YR RR F++IAY+YKHG P+P ++YT EEI+TWG ++R LTKLY THACRE+ PLL CG+REDNIPQLEDVS FL+ +GFTLRPVAG LSSRDFLAGLAFRVFH TQYIRHPS P YTPEPD CHELMGHVPL AD +FAQFSQEIGLASLGA +D +++L+T ++FT+E+G+C Q+GEL+AYGAGLLSS GEL++ L+++ ++ F+P+ + +T FQ Y+ SFE AK+K +FA +I +PF V YN YTQ +E LDS ++N++DNI E + NA+ K +
Sbjct: 22 EGVDIKEARNTCLLFSPKDSSLSSGALANILAIFKKHDINLVHIESRSSLRVPG-YEFFVEADGKSGALGKAIEDVKEQ-------------CSYFNIISRDYKDNATA--------------------VPWFPRRIRDLDRFANQILSYGSELDADHPGFTDPEYRKRRKYFADIAYNYKHGEPLPHVDYTKEEIETWGIIFRNLTKLYKTHACREYNHVFPLLVDNCGFREDNIPQLEDVSNFLRDCTGFTLRPVAGLLSSRDFLAGLAFRVFHSTQYIRHPSKPMYTPEPDVCHELMGHVPLFADPAFAQFSQEIGLASLGAPDDYIEKLSTIFWFTVEYGVCRQEGELKAYGAGLLSSYGELEYCLTDKPQLKDFEPEVTGVTKYPITQFQPLYYVADSFETAKEKTIKFANSIPRPFGVRYNAYTQSVEVLDSKPQISNLMDNINSEFQILQNAVAKLRV 452
BLAST of tph vs. Ensembl Fly
Match: ple (gene:FBgn0005626 transcript:FBtr0076956) HSP 1 Score: 400.979 bits (1029), Expect = 6.952e-134 Identity = 190/477 (39.83%), Postives = 296/477 (62.05%), Query Frame = 3
Query: 264 DFEIIKGELFDLNIVMEENKTISTRRSTSFIFGVNDNVKGLVRVLEIFEKFRVSVIHIETRKSLKNKSKFEIFIDVDCRKDEIKSLIECLQQKIDDDFHVQEVDMISSNINGIRIDTFDLAASEIGEQNIQLKNKKPGMTVDNLPWFPKYIKDLDKISNRVIMYGSELDADHPGFKDEVYRLRRNQFSEIAYSYKHGNPIPKIEYTNEEIKTWGNVYRELTKLYPTHACREFLQNLPLLQKYCGYREDNIPQLEDVSQFLKSRSGFTLRPVAGYLSSRDFLAGLAFRVFHCTQYIRHPSDPFYTPEPDCCHELMGHVPLLADSSFAQFSQEIGLASLGASEDEVQRLATCYFFTIEFGLCHQDGELRAYGAGLLSSIGELKHALSNESNIQKFDPKTVMEQECLVTTFQNAYFFTTSFEDAKDKMREFAKTIKKPFDVHYNPYTQMIETLDSTDSLTNVIDNIKGELATITNALRKF 1694
D+ + + E+ N E + + +S + + + + + L R+L+ E F +V H+E+R+S ++ I +D + + LI L+Q S + + + + + + N+ +K PWFPK+ +LD ++ + Y +LD +HPGF D+VYR RR + +EIA++YK+G+PIP I+Y++ E+KTW +V++ + L P HAC E+ LQ + E +PQL+++S FL+ +GF+LRP AG L++RDFLA LAFR+F TQY+RH + P++TPEPD HEL+GH+PLLAD SFAQFSQEIGLASLGAS++E+++L+T Y+FT+EFGLC + G+++AYGAGLLSS GEL HA+S++ + F+P + Q +Q Y+ SFEDAKDK R + T+ +PF+V +NP+T+ +E LDS D L ++ + E+ +TNA+ K
Sbjct: 61 DYGLTEDEILLANAASESSDAEAAMQSAALVVRLKEGISSLGRILKAIETFHGTVQHVESRQSRVEGVDHDVLIKLDMTRGNLLQLIRSLRQ--------------SGSFSSMNL---------MADNNLNVKA----------PWFPKHASELDNCNHLMTKYEPDLDMNHPGFADKVYRQRRKEIAEIAFAYKYGDPIPFIDYSDVEVKTWRSVFKTVQDLAPKHACAEYRAAFQKLQDEQIFVETRLPQLQEMSDFLRKNTGFSLRPAAGLLTARDFLASLAFRIFQSTQYVRHVNSPYHTPEPDSIHELLGHMPLLADPSFAQFSQEIGLASLGASDEEIEKLSTVYWFTVEFGLCKEHGQIKAYGAGLLSSYGELLHAISDKCEHRAFEPASTAVQPYQDQEYQPIYYVAESFEDAKDKFRRWVSTMSRPFEVRFNPHTERVEVLDSVDKLETLVHQMNTEILHLTNAISKL 504
BLAST of tph vs. Ensembl Zebrafish
Match: tph1a (tryptophan hydroxylase 1 (tryptophan 5-monooxygenase) a [Source:ZFIN;Acc:ZDB-GENE-030317-1]) HSP 1 Score: 583.563 bits (1503), Expect = 0.000e+0 Identity = 274/467 (58.67%), Postives = 350/467 (74.95%), Query Frame = 3
Query: 309 MEENKTISTRRS----TSFIFGVNDNVKGLVRVLEIFEKFRVSVIHIETRKSLKNKSKFEIFIDVDCRKDEIKSLIECLQQKIDDDFHVQEVDMISSNINGIRIDTFDLAASEIGEQNIQLKNKKPGMTVDNLPWFPKYIKDLDKISNRVIMYGSELDADHPGFKDEVYRLRRNQFSEIAYSYKHGNPIPKIEYTNEEIKTWGNVYRELTKLYPTHACREFLQNLPLLQKYCGYREDNIPQLEDVSQFLKSRSGFTLRPVAGYLSSRDFLAGLAFRVFHCTQYIRHPSDPFYTPEPDCCHELMGHVPLLADSSFAQFSQEIGLASLGASEDEVQRLATCYFFTIEFGLCHQDGELRAYGAGLLSSIGELKHALSNESNIQKFDPKTVMEQECLVTTFQNAYFFTTSFEDAKDKMREFAKTIKKPFDVHYNPYTQMIETLDSTDSLTNVIDNIKGELATITNALRKFN 1697
+EENK T S + +F + + V GLV+ L++F++ V+++HIE+RKS + S+FEIF+D D ++++ +I+ L++ ++N + +D D E E ++N+PWFPK I DLDK +NRV+MYGS+LDADHPGFKD VYR RR F+++A SYKHG+PIP+IE+T EE+KTWG V+REL KLYP+HACRE+L+NLPLL K+C REDNIPQLEDVS+FLK R+GFT+RPVAGYLS RDFLAGLAFRVFHCTQY+RH SDP YTPEPD CHEL+GHVPLLA+ SFAQFSQEIGLASLGAS+D +Q+LATCYFFT+EFGLC Q+G+LRAYGAGLLSSI ELKHALS + I FDP +QEC++TTFQ+ YF + SFE+AK KMREFAKTIK+PF V YNPYTQ ++ L T S+ NV++ ++ EL I +AL + N
Sbjct: 41 IEENKDNKTESSETGRAAVVFSLKNEVGGLVKALKLFQENHVNLVHIESRKSKRRNSEFEIFVDCDSNREQLHEIIQLLRK----------------HVNVVEMDAPDNRLPEESE-------------MENVPWFPKKISDLDKCANRVLMYGSDLDADHPGFKDNVYRKRRKYFADLAMSYKHGDPIPRIEFTEEEVKTWGVVFRELNKLYPSHACREYLKNLPLLIKHCDSREDNIPQLEDVSRFLKERTGFTIRPVAGYLSPRDFLAGLAFRVFHCTQYVRHSSDPLYTPEPDTCHELLGHVPLLAEPSFAQFSQEIGLASLGASDDSIQKLATCYFFTVEFGLCKQEGKLRAYGAGLLSSISELKHALSGNARILPFDPNVTCKQECIITTFQDVYFMSDSFEEAKVKMREFAKTIKRPFSVRYNPYTQSVDVLKDTTSINNVVEELRHELDIIGDALSRLN 478
BLAST of tph vs. Ensembl Zebrafish
Match: tph1a (tryptophan hydroxylase 1 (tryptophan 5-monooxygenase) a [Source:ZFIN;Acc:ZDB-GENE-030317-1]) HSP 1 Score: 583.563 bits (1503), Expect = 0.000e+0 Identity = 274/467 (58.67%), Postives = 350/467 (74.95%), Query Frame = 3
Query: 309 MEENKTISTRRS----TSFIFGVNDNVKGLVRVLEIFEKFRVSVIHIETRKSLKNKSKFEIFIDVDCRKDEIKSLIECLQQKIDDDFHVQEVDMISSNINGIRIDTFDLAASEIGEQNIQLKNKKPGMTVDNLPWFPKYIKDLDKISNRVIMYGSELDADHPGFKDEVYRLRRNQFSEIAYSYKHGNPIPKIEYTNEEIKTWGNVYRELTKLYPTHACREFLQNLPLLQKYCGYREDNIPQLEDVSQFLKSRSGFTLRPVAGYLSSRDFLAGLAFRVFHCTQYIRHPSDPFYTPEPDCCHELMGHVPLLADSSFAQFSQEIGLASLGASEDEVQRLATCYFFTIEFGLCHQDGELRAYGAGLLSSIGELKHALSNESNIQKFDPKTVMEQECLVTTFQNAYFFTTSFEDAKDKMREFAKTIKKPFDVHYNPYTQMIETLDSTDSLTNVIDNIKGELATITNALRKFN 1697
+EENK T S + +F + + V GLV+ L++F++ V+++HIE+RKS + S+FEIF+D D ++++ +I+ L++ ++N + +D D E E ++N+PWFPK I DLDK +NRV+MYGS+LDADHPGFKD VYR RR F+++A SYKHG+PIP+IE+T EE+KTWG V+REL KLYP+HACRE+L+NLPLL K+C REDNIPQLEDVS+FLK R+GFT+RPVAGYLS RDFLAGLAFRVFHCTQY+RH SDP YTPEPD CHEL+GHVPLLA+ SFAQFSQEIGLASLGAS+D +Q+LATCYFFT+EFGLC Q+G+LRAYGAGLLSSI ELKHALS + I FDP +QEC++TTFQ+ YF + SFE+AK KMREFAKTIK+PF V YNPYTQ ++ L T S+ NV++ ++ EL I +AL + N
Sbjct: 41 IEENKDNKTESSETGRAAVVFSLKNEVGGLVKALKLFQENHVNLVHIESRKSKRRNSEFEIFVDCDSNREQLHEIIQLLRK----------------HVNVVEMDAPDNRLPEESE-------------MENVPWFPKKISDLDKCANRVLMYGSDLDADHPGFKDNVYRKRRKYFADLAMSYKHGDPIPRIEFTEEEVKTWGVVFRELNKLYPSHACREYLKNLPLLIKHCDSREDNIPQLEDVSRFLKERTGFTIRPVAGYLSPRDFLAGLAFRVFHCTQYVRHSSDPLYTPEPDTCHELLGHVPLLAEPSFAQFSQEIGLASLGASDDSIQKLATCYFFTVEFGLCKQEGKLRAYGAGLLSSISELKHALSGNARILPFDPNVTCKQECIITTFQDVYFMSDSFEEAKVKMREFAKTIKRPFSVRYNPYTQSVDVLKDTTSINNVVEELRHELDIIGDALSRLN 478
BLAST of tph vs. Ensembl Zebrafish
Match: tph2 (tryptophan hydroxylase 2 (tryptophan 5-monooxygenase) [Source:ZFIN;Acc:ZDB-GENE-040624-4]) HSP 1 Score: 572.007 bits (1473), Expect = 0.000e+0 Identity = 272/468 (58.12%), Postives = 348/468 (74.36%), Query Frame = 3
Query: 312 EENKTISTRRSTSFIFGVNDNVKGLVRVLEIFEKFRVSVIHIETRKSLKNKSKFEIFIDVDCRKDEIKSLIECLQQKIDDDFHVQEVDMISSN----INGIRIDTFDLAASEIGEQNIQLKNKKPGMTVDNLPWFPKYIKDLDKISNRVIMYGSELDADHPGFKDEVYRLRRNQFSEIAYSYKHGNPIPKIEYTNEEIKTWGNVYRELTKLYPTHACREFLQNLPLLQKYCGYREDNIPQLEDVSQFLKSRSGFTLRPVAGYLSSRDFLAGLAFRVFHCTQYIRHPSDPFYTPEPDCCHELMGHVPLLADSSFAQFSQEIGLASLGASEDEVQRLATCYFFTIEFGLCHQDGELRAYGAGLLSSIGELKHALSNESNIQKFDPKTVMEQECLVTTFQNAYFFTTSFEDAKDKMREFAKTIKKPFDVHYNPYTQMIETLDSTDSLTNVIDNIKGELATITNALRKFNIF 1703
EE K+ + IF + + V LV+ L +F++ V++ HIE+R+S + ++ EI+ + +C K E L++ L+ V+++S N + D D G + + +PWFP+ I +LD+ S+RV+MYGSELDADHPGFKD+VYR RR F E+A +YK G PIP+IEYT EE+KTWG VYRELTKLYPTHACRE+L+NLPLL K+CGYREDNIPQLEDVS FL+ RSGFT+RPVAGYLS RDFLAGLA+RVF+CTQYIRH +DP YTPEPD CHEL+GHVPLLAD FAQFSQEIGLASLGAS+++VQ+LATCYFFTIEFGLC QDG+LR YGAGLLSSIGEL+HALS+++ ++ FDPKT QECL+TTFQ+ YF + SFE+AK+KMREFAK+IK+PF V+YNPYTQ I+ L T S+ NV+ +++ +L T+ +AL K N +
Sbjct: 50 EEQKSTHDLGKLAVIFSLKNEVGYLVKALRLFQEKHVNLAHIESRRSKRLTNEIEIYAECNCTKKEFNELVQHLKD---------HVNIVSYNTPQHVWSAETDCLDCVCVLGGLPD-----------GEGIPWFPQKISELDQCSHRVLMYGSELDADHPGFKDKVYRQRRKYFVEVAMNYKFGQPIPRIEYTAEEVKTWGVVYRELTKLYPTHACREYLKNLPLLTKHCGYREDNIPQLEDVSLFLRERSGFTVRPVAGYLSPRDFLAGLAYRVFNCTQYIRHSTDPLYTPEPDTCHELLGHVPLLADPKFAQFSQEIGLASLGASDEDVQKLATCYFFTIEFGLCKQDGQLRVYGAGLLSSIGELRHALSDKATVKVFDPKTTCYQECLITTFQDVYFVSESFEEAKEKMREFAKSIKRPFSVYYNPYTQSIDLLKDTRSIENVVQDLRSDLTTVCDALGKMNKY 497
BLAST of tph vs. Ensembl Zebrafish
Match: tph2 (tryptophan hydroxylase 2 (tryptophan 5-monooxygenase) [Source:ZFIN;Acc:ZDB-GENE-040624-4]) HSP 1 Score: 571.622 bits (1472), Expect = 0.000e+0 Identity = 272/468 (58.12%), Postives = 348/468 (74.36%), Query Frame = 3
Query: 312 EENKTISTRRSTSFIFGVNDNVKGLVRVLEIFEKFRVSVIHIETRKSLKNKSKFEIFIDVDCRKDEIKSLIECLQQKIDDDFHVQEVDMISSN----INGIRIDTFDLAASEIGEQNIQLKNKKPGMTVDNLPWFPKYIKDLDKISNRVIMYGSELDADHPGFKDEVYRLRRNQFSEIAYSYKHGNPIPKIEYTNEEIKTWGNVYRELTKLYPTHACREFLQNLPLLQKYCGYREDNIPQLEDVSQFLKSRSGFTLRPVAGYLSSRDFLAGLAFRVFHCTQYIRHPSDPFYTPEPDCCHELMGHVPLLADSSFAQFSQEIGLASLGASEDEVQRLATCYFFTIEFGLCHQDGELRAYGAGLLSSIGELKHALSNESNIQKFDPKTVMEQECLVTTFQNAYFFTTSFEDAKDKMREFAKTIKKPFDVHYNPYTQMIETLDSTDSLTNVIDNIKGELATITNALRKFNIF 1703
EE K+ + IF + + V LV+ L +F++ V++ HIE+R+S + ++ EI+ + +C K E L++ L+ V+++S N + D D G + + +PWFP+ I +LD+ S+RV+MYGSELDADHPGFKD+VYR RR F E+A +YK G PIP+IEYT EE+KTWG VYRELTKLYPTHACRE+L+NLPLL K+CGYREDNIPQLEDVS FL+ RSGFT+RPVAGYLS RDFLAGLA+RVF+CTQYIRH +DP YTPEPD CHEL+GHVPLLAD FAQFSQEIGLASLGAS+++VQ+LATCYFFTIEFGLC QDG+LR YGAGLLSSIGEL+HALS+++ ++ FDPKT QECL+TTFQ+ YF + SFE+AK+KMREFAK+IK+PF V+YNPYTQ I+ L T S+ NV+ +++ +L T+ +AL K N +
Sbjct: 50 EEQKSTHDLGKLAVIFSLKNEVGFLVKALRLFQEKHVNLAHIESRRSKRLTNEIEIYAECNCTKKEFNELVQHLKD---------HVNIVSYNTPQHVWSAETDCLDCVCVLGGLPD-----------GEGIPWFPQKISELDQCSHRVLMYGSELDADHPGFKDKVYRQRRKYFVEVAMNYKFGQPIPRIEYTAEEVKTWGVVYRELTKLYPTHACREYLKNLPLLTKHCGYREDNIPQLEDVSLFLRERSGFTVRPVAGYLSPRDFLAGLAYRVFNCTQYIRHSTDPLYTPEPDTCHELLGHVPLLADPKFAQFSQEIGLASLGASDEDVQKLATCYFFTIEFGLCKQDGQLRVYGAGLLSSIGELRHALSDKATVKVFDPKTTCYQECLITTFQDVYFVSESFEEAKEKMREFAKSIKRPFSVYYNPYTQSIDLLKDTRSIENVVQDLRSDLTTVCDALGKMNKY 497
BLAST of tph vs. Ensembl Zebrafish
Match: tph2 (tryptophan hydroxylase 2 (tryptophan 5-monooxygenase) [Source:ZFIN;Acc:ZDB-GENE-040624-4]) HSP 1 Score: 570.081 bits (1468), Expect = 0.000e+0 Identity = 272/468 (58.12%), Postives = 348/468 (74.36%), Query Frame = 3
Query: 312 EENKTISTRRSTSFIFGVNDNVKGLVRVLEIFEKFRVSVIHIETRKSLKNKSKFEIFIDVDCRKDEIKSLIECLQQKIDDDFHVQEVDMISSN----INGIRIDTFDLAASEIGEQNIQLKNKKPGMTVDNLPWFPKYIKDLDKISNRVIMYGSELDADHPGFKDEVYRLRRNQFSEIAYSYKHGNPIPKIEYTNEEIKTWGNVYRELTKLYPTHACREFLQNLPLLQKYCGYREDNIPQLEDVSQFLKSRSGFTLRPVAGYLSSRDFLAGLAFRVFHCTQYIRHPSDPFYTPEPDCCHELMGHVPLLADSSFAQFSQEIGLASLGASEDEVQRLATCYFFTIEFGLCHQDGELRAYGAGLLSSIGELKHALSNESNIQKFDPKTVMEQECLVTTFQNAYFFTTSFEDAKDKMREFAKTIKKPFDVHYNPYTQMIETLDSTDSLTNVIDNIKGELATITNALRKFNIF 1703
EE K+ + IF + + V LV+ L +F++ V++ HIE+R+S + ++ EI+ + +C K E L++ L+ V+++S N + D D G + + +PWFP+ I +LD+ S+RV+MYGSELDADHPGFKD+VYR RR F E+A +YK G PIP+IEYT EE+KTWG VYRELTKLYPTHACRE+L+NLPLL K+CGYREDNIPQLEDVS FL+ RSGFT+RPVAGYLS RDFLAGLA+RVF+CTQYIRH +DP YTPEPD CHEL+GHVPLLAD FAQFSQEIGLASLGAS+++VQ+LATCYFFTIEFGLC QDG+LR YGAGLLSSIGEL+HALS+++ ++ FDPKT QECL+TTFQ+ YF + SFE+AK+KMREFAK+IK+PF V+YNPYTQ I+ L T S+ NV+ +++ +L T+ +AL K N +
Sbjct: 23 EEQKSTHDLGKLAVIFSLKNEVGFLVKALRLFQEKHVNLAHIESRRSKRLTNEIEIYAECNCTKKEFNELVQHLKD---------HVNIVSYNTPQHVWSAETDCLDCVCVLGGLPD-----------GEGIPWFPQKISELDQCSHRVLMYGSELDADHPGFKDKVYRQRRKYFVEVAMNYKFGQPIPRIEYTAEEVKTWGVVYRELTKLYPTHACREYLKNLPLLTKHCGYREDNIPQLEDVSLFLRERSGFTVRPVAGYLSPRDFLAGLAYRVFNCTQYIRHSTDPLYTPEPDTCHELLGHVPLLADPKFAQFSQEIGLASLGASDEDVQKLATCYFFTIEFGLCKQDGQLRVYGAGLLSSIGELRHALSDKATVKVFDPKTTCYQECLITTFQDVYFVSESFEEAKEKMREFAKSIKRPFSVYYNPYTQSIDLLKDTRSIENVVQDLRSDLTTVCDALGKMNKY 470
BLAST of tph vs. Ensembl Xenopus
Match: TPH2 (tryptophan hydroxylase 2 [Source:NCBI gene;Acc:100486097]) HSP 1 Score: 573.548 bits (1477), Expect = 0.000e+0 Identity = 275/475 (57.89%), Postives = 359/475 (75.58%), Query Frame = 3
Query: 297 LNIV-MEENKTISTRRS-----TSFIFGVNDNVKGLVRVLEIFEKFRVSVIHIETRKSLKNKSKFEIFIDVDCRKDEIKSLIECLQQKIDDDFHVQEVDMISSNINGIRIDTFDLAASEIGEQNIQLKNKKPGMTVDNLPWFPKYIKDLDKISNRVIMYGSELDADHPGFKDEVYRLRRNQFSEIAYSYKHGNPIPKIEYTNEEIKTWGNVYRELTKLYPTHACREFLQNLPLLQKYCGYREDNIPQLEDVSQFLKSRSGFTLRPVAGYLSSRDFLAGLAFRVFHCTQYIRHPSDPFYTPEPDCCHELMGHVPLLADSSFAQFSQEIGLASLGASEDEVQRLATCYFFTIEFGLCHQDGELRAYGAGLLSSIGELKHALSNESNIQKFDPKTVMEQECLVTTFQNAYFFTTSFEDAKDKMREFAKTIKKPFDVHYNPYTQMIETLDSTDSLTNVIDNIKGELATITNALRKFNIF 1703
LN++ ++ENK T + T+ I + + V GL++ L+IF++ V++IHIE+RKS NKS+ +++++ +C K + + L L+ + +IS N I ++ +L + + WFP+ I +LDK SNRV+MYGSELDADHPGFKD VYR RR F ++A YK+G PIP++EYT EEIKTWG V++ELTKLYPTHAC+E+L+NLPLL KYCGYREDN+PQLEDV+ FLK RSGFT+RPVAGYLS RDFLAGLA+RVFHCTQYIRH SDP YTPEPD CHEL+GHVPLLAD FAQFSQEIGLASLGAS+++VQ+LATCYFFTIEFGLC QDG+LRAYGAGLLSSIGELKHALS+++ ++ FDPKT QEC++TTFQ++YF + SF++AK+KMREFAK+I +PF V++NPYTQ IE ++T S+ NVI +++ +L T+++AL K N +
Sbjct: 37 LNVLRIDENKCSKTEATAETERTAVILTMKNEVGGLLQNLKIFKEKYVNIIHIESRKSKGNKSEVDMYVEFECTKKKCQELQHLLKL---------QSGIISVN-----------PVERIWRKDEEL---------EGVLWFPRKISELDKCSNRVLMYGSELDADHPGFKDNVYRQRRKYFVDVAMDYKYGQPIPRVEYTAEEIKTWGTVFKELTKLYPTHACKEYLKNLPLLTKYCGYREDNVPQLEDVAIFLKERSGFTVRPVAGYLSPRDFLAGLAYRVFHCTQYIRHGSDPLYTPEPDTCHELLGHVPLLADPKFAQFSQEIGLASLGASDEDVQKLATCYFFTIEFGLCKQDGQLRAYGAGLLSSIGELKHALSDKAIVKTFDPKTTCLQECIITTFQDSYFVSESFDEAKEKMREFAKSINRPFSVYFNPYTQSIEIFNNTRSIENVIQDLRSDLNTVSDALAKMNKY 482
BLAST of tph vs. Ensembl Xenopus
Match: taar2 (trace amine associated receptor 2 (gene/pseudogene) [Source:Xenbase;Acc:XB-GENE-961117]) HSP 1 Score: 551.977 bits (1421), Expect = 0.000e+0 Identity = 267/462 (57.79%), Postives = 341/462 (73.81%), Query Frame = 3
Query: 312 EENKTISTRRSTSFIFGVNDNVKGLVRVLEIFEKFRVSVIHIETRKSLKNKSKFEIFIDVDCRKDEIKSLIECLQQKIDDDFHVQEVDMISSNINGIRIDTFDLAASEIGEQNIQLKNKKPGMTVDNLPWFPKYIKDLDKISNRVIMYGSELDADHPGFKDEVYRLRRNQFSEIAYSYKHGNPIPKIEYTNEEIKTWGNVYRELTKLYPTHACREFLQNLPLLQKYCGYREDNIPQLEDVSQFLKSRSGFTLRPVAGYLSSRDFLAGLAFRVFHCTQYIRHPSDPFYTPEPDCCHELMGHVPLLADSSFAQFSQEIGLASLGASEDEVQRLATCYFFTIEFGLCHQDGELRAYGAGLLSSIGELKHALSNESNIQKFDPKTVMEQECLVTTFQNAYFFTTSFEDAKDKMREFAKTIKKPFDVHYNPYTQMIETLDSTDSLTNVIDNIKGELATITNALRKFN 1697
E N + R S IF + + + GLV+ L++F++ V++IHIE+RKS + S+FEIF+D D ++++ + L+ HV + M + + E G KNK +PWFPK I DLDK +NRV+MYGS+LDADHPGFKD VYR RR F+++A SY++G+PIP+IE+T EEI+TWG V+REL KLYPTHACRE+L+NLPLL KYCGYREDNIPQLEDVS+FL+ R+GFT+RPVAGYLS RDFLAGLAFRVFHCTQY+RH SDP YTPEPD CHEL+GHVPLLA+ SFAQFSQEIGLASLGAS++ VQ+LATCYFFT+EFGLC Q+G+L+ YGAGLLSSI ELKH+LS + + FDP QEC++T+FQ YF + SFE+AK+KMREFAKTIK+PF + YNP+TQ ++ L T S+ V+ ++ EL + +AL K N
Sbjct: 20 EYNDNVCERGKASVIFSLKNEIGGLVKALKLFQEKHVNLIHIESRKSKRRNSEFEIFVDCDSNREQLNEIFHLLKP------HVSVISMSPPE---------NFSVEEDG------KNK-------GVPWFPKRISDLDKCANRVLMYGSDLDADHPGFKDNVYRKRRKYFADVAMSYRYGDPIPRIEFTEEEIETWGTVFRELNKLYPTHACREYLKNLPLLSKYCGYREDNIPQLEDVSRFLRERTGFTIRPVAGYLSPRDFLAGLAFRVFHCTQYVRHSSDPLYTPEPDTCHELLGHVPLLAEPSFAQFSQEIGLASLGASDEAVQKLATCYFFTVEFGLCKQEGKLKVYGAGLLSSISELKHSLSGNAKFKPFDPMVTCNQECIITSFQELYFVSESFEEAKEKMREFAKTIKRPFGLKYNPFTQSVDLLKDTKSIAMVVSELRHELDIVNDALNKMN 453
BLAST of tph vs. Ensembl Xenopus
Match: taar2 (trace amine associated receptor 2 (gene/pseudogene) [Source:Xenbase;Acc:XB-GENE-961117]) HSP 1 Score: 551.592 bits (1420), Expect = 0.000e+0 Identity = 264/469 (56.29%), Postives = 341/469 (72.71%), Query Frame = 3
Query: 312 EENKTISTRRSTSFIFGVNDNVKGLVRVLEIFEKFRVSVIHIETRKSLKNKSKFEIFIDVDCRKDEIKSLIECLQQKID-------DDFHVQEVDMISSNINGIRIDTFDLAASEIGEQNIQLKNKKPGMTVDNLPWFPKYIKDLDKISNRVIMYGSELDADHPGFKDEVYRLRRNQFSEIAYSYKHGNPIPKIEYTNEEIKTWGNVYRELTKLYPTHACREFLQNLPLLQKYCGYREDNIPQLEDVSQFLKSRSGFTLRPVAGYLSSRDFLAGLAFRVFHCTQYIRHPSDPFYTPEPDCCHELMGHVPLLADSSFAQFSQEIGLASLGASEDEVQRLATCYFFTIEFGLCHQDGELRAYGAGLLSSIGELKHALSNESNIQKFDPKTVMEQECLVTTFQNAYFFTTSFEDAKDKMREFAKTIKKPFDVHYNPYTQMIETLDSTDSLTNVIDNIKGELATITNALRKFN 1697
E N + R S IF + + + GLV+ L++F++ V++IHIE+RKS + S+FEIF+D D ++++ + L+ + ++F V+E DM +++PWFPK I DLDK +NRV+MYGS+LDADHPGFKD VYR RR F+++A SY++G+PIP+IE+T EEI+TWG V+REL KLYPTHACRE+L+NLPLL KYCGYREDNIPQLEDVS+FL+ R+GFT+RPVAGYLS RDFLAGLAFRVFHCTQY+RH SDP YTPEPD CHEL+GHVPLLA+ SFAQFSQEIGLASLGAS++ VQ+LATCYFFT+EFGLC Q+G+L+ YGAGLLSSI ELKH+LS + + FDP QEC++T+FQ YF + SFE+AK+KMREFAKTIK+PF + YNP+TQ ++ L T S+ V+ ++ EL + +AL K N
Sbjct: 24 EYNDNVCERGKASVIFSLKNEIGGLVKALKLFQEKHVNLIHIESRKSKRRNSEFEIFVDCDSNREQLNEIFHLLKPHVSVISMSPPENFSVEEDDM------------------------------------ESVPWFPKRISDLDKCANRVLMYGSDLDADHPGFKDNVYRKRRKYFADVAMSYRYGDPIPRIEFTEEEIETWGTVFRELNKLYPTHACREYLKNLPLLSKYCGYREDNIPQLEDVSRFLRERTGFTIRPVAGYLSPRDFLAGLAFRVFHCTQYVRHSSDPLYTPEPDTCHELLGHVPLLAEPSFAQFSQEIGLASLGASDEAVQKLATCYFFTVEFGLCKQEGKLKVYGAGLLSSISELKHSLSGNAKFKPFDPMVTCNQECIITSFQELYFVSESFEEAKEKMREFAKTIKRPFGLKYNPFTQSVDLLKDTKSIAMVVSELRHELDIVNDALNKMN 456
BLAST of tph vs. Ensembl Xenopus
Match: taar2 (trace amine associated receptor 2 (gene/pseudogene) [Source:Xenbase;Acc:XB-GENE-961117]) HSP 1 Score: 551.592 bits (1420), Expect = 0.000e+0 Identity = 264/469 (56.29%), Postives = 341/469 (72.71%), Query Frame = 3
Query: 312 EENKTISTRRSTSFIFGVNDNVKGLVRVLEIFEKFRVSVIHIETRKSLKNKSKFEIFIDVDCRKDEIKSLIECLQQKID-------DDFHVQEVDMISSNINGIRIDTFDLAASEIGEQNIQLKNKKPGMTVDNLPWFPKYIKDLDKISNRVIMYGSELDADHPGFKDEVYRLRRNQFSEIAYSYKHGNPIPKIEYTNEEIKTWGNVYRELTKLYPTHACREFLQNLPLLQKYCGYREDNIPQLEDVSQFLKSRSGFTLRPVAGYLSSRDFLAGLAFRVFHCTQYIRHPSDPFYTPEPDCCHELMGHVPLLADSSFAQFSQEIGLASLGASEDEVQRLATCYFFTIEFGLCHQDGELRAYGAGLLSSIGELKHALSNESNIQKFDPKTVMEQECLVTTFQNAYFFTTSFEDAKDKMREFAKTIKKPFDVHYNPYTQMIETLDSTDSLTNVIDNIKGELATITNALRKFN 1697
E N + R S IF + + + GLV+ L++F++ V++IHIE+RKS + S+FEIF+D D ++++ + L+ + ++F V+E DM +++PWFPK I DLDK +NRV+MYGS+LDADHPGFKD VYR RR F+++A SY++G+PIP+IE+T EEI+TWG V+REL KLYPTHACRE+L+NLPLL KYCGYREDNIPQLEDVS+FL+ R+GFT+RPVAGYLS RDFLAGLAFRVFHCTQY+RH SDP YTPEPD CHEL+GHVPLLA+ SFAQFSQEIGLASLGAS++ VQ+LATCYFFT+EFGLC Q+G+L+ YGAGLLSSI ELKH+LS + + FDP QEC++T+FQ YF + SFE+AK+KMREFAKTIK+PF + YNP+TQ ++ L T S+ V+ ++ EL + +AL K N
Sbjct: 57 EYNDNVCERGKASVIFSLKNEIGGLVKALKLFQEKHVNLIHIESRKSKRRNSEFEIFVDCDSNREQLNEIFHLLKPHVSVISMSPPENFSVEEDDM------------------------------------ESVPWFPKRISDLDKCANRVLMYGSDLDADHPGFKDNVYRKRRKYFADVAMSYRYGDPIPRIEFTEEEIETWGTVFRELNKLYPTHACREYLKNLPLLSKYCGYREDNIPQLEDVSRFLRERTGFTIRPVAGYLSPRDFLAGLAFRVFHCTQYVRHSSDPLYTPEPDTCHELLGHVPLLAEPSFAQFSQEIGLASLGASDEAVQKLATCYFFTVEFGLCKQEGKLKVYGAGLLSSISELKHSLSGNAKFKPFDPMVTCNQECIITSFQELYFVSESFEEAKEKMREFAKTIKRPFGLKYNPFTQSVDLLKDTKSIAMVVSELRHELDIVNDALNKMN 489
BLAST of tph vs. Ensembl Xenopus
Match: taar2 (trace amine associated receptor 2 (gene/pseudogene) [Source:Xenbase;Acc:XB-GENE-961117]) HSP 1 Score: 551.592 bits (1420), Expect = 0.000e+0 Identity = 264/469 (56.29%), Postives = 341/469 (72.71%), Query Frame = 3
Query: 312 EENKTISTRRSTSFIFGVNDNVKGLVRVLEIFEKFRVSVIHIETRKSLKNKSKFEIFIDVDCRKDEIKSLIECLQQKID-------DDFHVQEVDMISSNINGIRIDTFDLAASEIGEQNIQLKNKKPGMTVDNLPWFPKYIKDLDKISNRVIMYGSELDADHPGFKDEVYRLRRNQFSEIAYSYKHGNPIPKIEYTNEEIKTWGNVYRELTKLYPTHACREFLQNLPLLQKYCGYREDNIPQLEDVSQFLKSRSGFTLRPVAGYLSSRDFLAGLAFRVFHCTQYIRHPSDPFYTPEPDCCHELMGHVPLLADSSFAQFSQEIGLASLGASEDEVQRLATCYFFTIEFGLCHQDGELRAYGAGLLSSIGELKHALSNESNIQKFDPKTVMEQECLVTTFQNAYFFTTSFEDAKDKMREFAKTIKKPFDVHYNPYTQMIETLDSTDSLTNVIDNIKGELATITNALRKFN 1697
E N + R S IF + + + GLV+ L++F++ V++IHIE+RKS + S+FEIF+D D ++++ + L+ + ++F V+E DM +++PWFPK I DLDK +NRV+MYGS+LDADHPGFKD VYR RR F+++A SY++G+PIP+IE+T EEI+TWG V+REL KLYPTHACRE+L+NLPLL KYCGYREDNIPQLEDVS+FL+ R+GFT+RPVAGYLS RDFLAGLAFRVFHCTQY+RH SDP YTPEPD CHEL+GHVPLLA+ SFAQFSQEIGLASLGAS++ VQ+LATCYFFT+EFGLC Q+G+L+ YGAGLLSSI ELKH+LS + + FDP QEC++T+FQ YF + SFE+AK+KMREFAKTIK+PF + YNP+TQ ++ L T S+ V+ ++ EL + +AL K N
Sbjct: 44 EYNDNVCERGKASVIFSLKNEIGGLVKALKLFQEKHVNLIHIESRKSKRRNSEFEIFVDCDSNREQLNEIFHLLKPHVSVISMSPPENFSVEEDDM------------------------------------ESVPWFPKRISDLDKCANRVLMYGSDLDADHPGFKDNVYRKRRKYFADVAMSYRYGDPIPRIEFTEEEIETWGTVFRELNKLYPTHACREYLKNLPLLSKYCGYREDNIPQLEDVSRFLRERTGFTIRPVAGYLSPRDFLAGLAFRVFHCTQYVRHSSDPLYTPEPDTCHELLGHVPLLAEPSFAQFSQEIGLASLGASDEAVQKLATCYFFTVEFGLCKQEGKLKVYGAGLLSSISELKHSLSGNAKFKPFDPMVTCNQECIITSFQELYFVSESFEEAKEKMREFAKTIKRPFGLKYNPFTQSVDLLKDTKSIAMVVSELRHELDIVNDALNKMN 476
BLAST of tph vs. Ensembl Mouse
Match: Tph1 (tryptophan hydroxylase 1 [Source:MGI Symbol;Acc:MGI:98796]) HSP 1 Score: 582.793 bits (1501), Expect = 0.000e+0 Identity = 274/461 (59.44%), Postives = 351/461 (76.14%), Query Frame = 3
Query: 312 EENKTISTRRS-TSFIFGVNDNVKGLVRVLEIFEKFRVSVIHIETRKSLKNKSKFEIFIDVDCRKDEIKSLIECLQQKIDDDFHVQEVDMISSNINGIRIDTFDLAASEIGEQNIQLKNKKPGMTVDNLPWFPKYIKDLDKISNRVIMYGSELDADHPGFKDEVYRLRRNQFSEIAYSYKHGNPIPKIEYTNEEIKTWGNVYRELTKLYPTHACREFLQNLPLLQKYCGYREDNIPQLEDVSQFLKSRSGFTLRPVAGYLSSRDFLAGLAFRVFHCTQYIRHPSDPFYTPEPDCCHELMGHVPLLADSSFAQFSQEIGLASLGASEDEVQRLATCYFFTIEFGLCHQDGELRAYGAGLLSSIGELKHALSNESNIQKFDPKTVMEQECLVTTFQNAYFFTTSFEDAKDKMREFAKTIKKPFDVHYNPYTQMIETLDSTDSLTNVIDNIKGELATITNALRK 1691
+ENK S+ R + IF + + V GL++VL+IF++ VS++HIE+RKS + S+FEIF+D D ++++ + L+ S+ + +D+ D QL K+ M + +PWFPK I DLD +NRV++YGSELDADHPGFKD VYR RR F+E+A +YKHG+PIPKIE+T EEIKTWG ++REL KLYPTHACRE+L+NLPLL KYCGYREDNIPQLEDVS FLK R+GF++RPVAGYLS RDFL+GLAFRVFHCTQY+RH SDP YTPEPD CHEL+GHVPLLA+ SFAQFSQEIGLASLGASE+ VQ+LATCYFFT+EFGLC QDG+LR +GAGLLSSI ELKHALS + ++ FDPK +QECL+T+FQ+ YF + SFEDAK+KMREFAKT+K+PF + YNPYTQ ++ L T S+T+ ++ ++ +L I++AL +
Sbjct: 9 KENKDHSSERGRVTLIFSLENEVGGLIKVLKIFQENHVSLLHIESRKSKQRNSEFEIFVDCDISREQLNDIFPLLK----------------SHATVLSVDSPD-----------QLTAKEDVM--ETVPWFPKKISDLDFCANRVLLYGSELDADHPGFKDNVYRRRRKYFAELAMNYKHGDPIPKIEFTEEEIKTWGTIFRELNKLYPTHACREYLRNLPLLSKYCGYREDNIPQLEDVSNFLKERTGFSIRPVAGYLSPRDFLSGLAFRVFHCTQYVRHSSDPLYTPEPDTCHELLGHVPLLAEPSFAQFSQEIGLASLGASEETVQKLATCYFFTVEFGLCKQDGQLRVFGAGLLSSISELKHALSGHAKVKPFDPKIACKQECLITSFQDVYFVSESFEDAKEKMREFAKTVKRPFGLKYNPYTQSVQVLRDTKSITSAMNELRYDLDVISDALAR 440
BLAST of tph vs. Ensembl Mouse
Match: Tph1 (tryptophan hydroxylase 1 [Source:MGI Symbol;Acc:MGI:98796]) HSP 1 Score: 582.793 bits (1501), Expect = 0.000e+0 Identity = 274/461 (59.44%), Postives = 351/461 (76.14%), Query Frame = 3
Query: 312 EENKTISTRRS-TSFIFGVNDNVKGLVRVLEIFEKFRVSVIHIETRKSLKNKSKFEIFIDVDCRKDEIKSLIECLQQKIDDDFHVQEVDMISSNINGIRIDTFDLAASEIGEQNIQLKNKKPGMTVDNLPWFPKYIKDLDKISNRVIMYGSELDADHPGFKDEVYRLRRNQFSEIAYSYKHGNPIPKIEYTNEEIKTWGNVYRELTKLYPTHACREFLQNLPLLQKYCGYREDNIPQLEDVSQFLKSRSGFTLRPVAGYLSSRDFLAGLAFRVFHCTQYIRHPSDPFYTPEPDCCHELMGHVPLLADSSFAQFSQEIGLASLGASEDEVQRLATCYFFTIEFGLCHQDGELRAYGAGLLSSIGELKHALSNESNIQKFDPKTVMEQECLVTTFQNAYFFTTSFEDAKDKMREFAKTIKKPFDVHYNPYTQMIETLDSTDSLTNVIDNIKGELATITNALRK 1691
+ENK S+ R + IF + + V GL++VL+IF++ VS++HIE+RKS + S+FEIF+D D ++++ + L+ S+ + +D+ D QL K+ M + +PWFPK I DLD +NRV++YGSELDADHPGFKD VYR RR F+E+A +YKHG+PIPKIE+T EEIKTWG ++REL KLYPTHACRE+L+NLPLL KYCGYREDNIPQLEDVS FLK R+GF++RPVAGYLS RDFL+GLAFRVFHCTQY+RH SDP YTPEPD CHEL+GHVPLLA+ SFAQFSQEIGLASLGASE+ VQ+LATCYFFT+EFGLC QDG+LR +GAGLLSSI ELKHALS + ++ FDPK +QECL+T+FQ+ YF + SFEDAK+KMREFAKT+K+PF + YNPYTQ ++ L T S+T+ ++ ++ +L I++AL +
Sbjct: 9 KENKDHSSERGRVTLIFSLENEVGGLIKVLKIFQENHVSLLHIESRKSKQRNSEFEIFVDCDISREQLNDIFPLLK----------------SHATVLSVDSPD-----------QLTAKEDVM--ETVPWFPKKISDLDFCANRVLLYGSELDADHPGFKDNVYRRRRKYFAELAMNYKHGDPIPKIEFTEEEIKTWGTIFRELNKLYPTHACREYLRNLPLLSKYCGYREDNIPQLEDVSNFLKERTGFSIRPVAGYLSPRDFLSGLAFRVFHCTQYVRHSSDPLYTPEPDTCHELLGHVPLLAEPSFAQFSQEIGLASLGASEETVQKLATCYFFTVEFGLCKQDGQLRVFGAGLLSSISELKHALSGHAKVKPFDPKIACKQECLITSFQDVYFVSESFEDAKEKMREFAKTVKRPFGLKYNPYTQSVQVLRDTKSITSAMNELRYDLDVISDALAR 440
BLAST of tph vs. Ensembl Mouse
Match: Tph2 (tryptophan hydroxylase 2 [Source:MGI Symbol;Acc:MGI:2651811]) HSP 1 Score: 570.852 bits (1470), Expect = 0.000e+0 Identity = 273/465 (58.71%), Postives = 349/465 (75.05%), Query Frame = 3
Query: 312 EENKTISTRRS-TSFIFGVNDNVKGLVRVLEIFEKFRVSVIHIETRKSLKNKSKFEIFIDVDCRKDEIKSLIECLQQKIDDDFHVQEVDMISSNINGIRIDTFDLAASEIGEQNIQLKNKKPGMTVDNLPWFPKYIKDLDKISNRVIMYGSELDADHPGFKDEVYRLRRNQFSEIAYSYKHGNPIPKIEYTNEEIKTWGNVYRELTKLYPTHACREFLQNLPLLQKYCGYREDNIPQLEDVSQFLKSRSGFTLRPVAGYLSSRDFLAGLAFRVFHCTQYIRHPSDPFYTPEPDCCHELMGHVPLLADSSFAQFSQEIGLASLGASEDEVQRLATCYFFTIEFGLCHQDGELRAYGAGLLSSIGELKHALSNESNIQKFDPKTVMEQECLVTTFQNAYFFTTSFEDAKDKMREFAKTIKKPFDVHYNPYTQMIETLDSTDSLTNVIDNIKGELATITNALRKFNIF 1703
E K +T S T+ +F + + V GLV+ L +F++ V+++HIE+R+S + S+ EIF+D +C K E LI+ L+ Q + + I + DL +++PWFP+ I +LD+ S+RV+MYG+ELDADHPGFKD VYR RR F ++A YK+G PIP++EYT EE KTWG V+REL+KLYPTHACRE+L+NLPLL KYCGYREDN+PQLEDVS FLK RSGFT+RPVAGYLS RDFLAGLA+RVFHCTQY+RH SDP YTPEPD CHEL+GHVPLLAD FAQFSQEIGLASLGAS+++VQ+LATCYFFTIEFGLC Q+G+LRAYGAGLLSSIGELKHALS+++ ++ FDPKT QECL+TTFQ+AYF + SFE+AK+KMR+FAK+I +PF V++NPYTQ IE L T S+ NV+ +++ +L T+ +AL K N +
Sbjct: 50 EPGKGDTTESSKTAVVFSLKNEVGGLVKALRLFQEKHVNMLHIESRRSRRRSSEVEIFVDCECGKTEFNELIQLLK--------FQTTIVTLNPPESIWTEEEDL---------------------EDVPWFPRKISELDRCSHRVLMYGTELDADHPGFKDNVYRQRRKYFVDVAMGYKYGQPIPRVEYTEEETKTWGVVFRELSKLYPTHACREYLKNLPLLTKYCGYREDNVPQLEDVSMFLKERSGFTVRPVAGYLSPRDFLAGLAYRVFHCTQYVRHGSDPLYTPEPDTCHELLGHVPLLADPKFAQFSQEIGLASLGASDEDVQKLATCYFFTIEFGLCKQEGQLRAYGAGLLSSIGELKHALSDKACVKSFDPKTTCLQECLITTFQDAYFVSDSFEEAKEKMRDFAKSITRPFSVYFNPYTQSIEILKDTRSIENVVQDLRSDLNTVCDALNKMNQY 485
BLAST of tph vs. Ensembl Mouse
Match: Pah (phenylalanine hydroxylase [Source:MGI Symbol;Acc:MGI:97473]) HSP 1 Score: 479.174 bits (1232), Expect = 5.043e-165 Identity = 234/450 (52.00%), Postives = 304/450 (67.56%), Query Frame = 3
Query: 342 STSFIFGVNDNVKGLVRVLEIFEKFRVSVIHIETRKSLKNKSKFEIFIDVDCRKDEIKSLIECLQQKIDDDFHVQEVDMISSNINGIRIDTFDLAASEIGEQNIQLKNKKPGMTVDNLPWFPKYIKDLDKISNRVIMYGSELDADHPGFKDEVYRLRRNQFSEIAYSYKHGNPIPKIEYTNEEIKTWGNVYRELTKLYPTHACREFLQNLPLLQKYCGYREDNIPQLEDVSQFLKSRSGFTLRPVAGYLSSRDFLAGLAFRVFHCTQYIRHPSDPFYTPEPDCCHELMGHVPLLADSSFAQFSQEIGLASLGASEDEVQRLATCYFFTIEFGLCHQDGELRAYGAGLLSSIGELKHALSNESNIQKFDPKTVMEQECLVTTFQNAYFFTTSFEDAKDKMREFAKTIKKPFDVHYNPYTQMIETLDSTDSLTNVIDNIKGELATITNALRK 1691
+ S IF + + V L +VL +FE+ +++ HIE+R S NK ++E F +D R + + S I +R D IG +L K TV PWFP+ I++LD+ +N+++ YG+ELDADHPGFKD VYR RR QF++IAY+Y+HG PIP++EYT EE KTWG V+R L LY THAC E PLL+KYCG+REDNIPQLEDVSQFL++ +GF LRPVAG LSSRDFL GLAFRVFHCTQYIRH S P YTPEPD CHEL+GHVPL +D SFAQFSQEIGLASLGA ++ +++LAT Y+FT+EFGLC + ++AYGAGLLSS GEL++ LS++ + + + QE VT FQ Y+ SF DAK+K+R FA TI +PF V Y+PYTQ +E LD+T L + D+I E+ + +AL+K
Sbjct: 34 AVSLIFSLKEEVGALAKVLRLFEENEINLTHIESRPSRLNKDEYEFFTYLDKRSKPV----------------------LGSIIKSLRND--------IGATVHELSRDKEKNTV---PWFPRTIQELDRFANQILSYGAELDADHPGFKDPVYRARRKQFADIAYNYRHGQPIPRVEYTEEERKTWGTVFRTLKALYKTHACYEHNHIFPLLEKYCGFREDNIPQLEDVSQFLQTCTGFRLRPVAGLLSSRDFLGGLAFRVFHCTQYIRHGSKPMYTPEPDICHELLGHVPLFSDRSFAQFSQEIGLASLGAPDEYIEKLATIYWFTVEFGLCKEGDSIKAYGAGLLSSFGELQYCLSDKPKLLPLELEKTACQEYTVTEFQPLYYVAESFNDAKEKVRTFAATIPRPFSVRYDPYTQRVEVLDNTQQLKILADSINSEVGILCHALQK 450
BLAST of tph vs. Ensembl Mouse
Match: Th (tyrosine hydroxylase [Source:MGI Symbol;Acc:MGI:98735]) HSP 1 Score: 452.21 bits (1162), Expect = 6.358e-154 Identity = 215/437 (49.20%), Postives = 282/437 (64.53%), Query Frame = 3
Query: 384 LVRVLEIFEKFRVSVIHIETR---KSLKNKSKFEIFIDVDCRKDEIKSLIECLQQKIDDDFHVQEVDMISSNINGIRIDTFDLAASEIGEQNIQLKNKKPGMTVDNLPWFPKYIKDLDKISNRVIMYGSELDADHPGFKDEVYRLRRNQFSEIAYSYKHGNPIPKIEYTNEEIKTWGNVYRELTKLYPTHACREFLQNLPLLQKYCGYREDNIPQLEDVSQFLKSRSGFTLRPVAGYLSSRDFLAGLAFRVFHCTQYIRHPSDPFYTPEPDCCHELMGHVPLLADSSFAQFSQEIGLASLGASEDEVQRLATCYFFTIEFGLCHQDGELRAYGAGLLSSIGELKHALSNESNIQKFDPKTVMEQECLVTTFQNAYFFTTSFEDAKDKMREFAKTIKKPFDVHYNPYTQMIETLDSTDSLTNVIDNIKGELATITNAL 1685
L R L++FE F + H+ETR + L E F+ + ++ +L+ +++ DD +E D +PWFP+ + +LDK + V + +LD DHPGF D+ YR RR +EIA+ YK G PIP +EYT EEI TW VY L LY THACRE L+ LL++YCGYRED+IPQLEDVS FLK R+GF LRPVAG LS+RDFLA LAFRVF CTQYIRH S P ++PEPDCCHEL+GHVP+LAD +FAQFSQ+IGLASLGAS++E+++L+T Y+FT+EFGLC Q+GEL+AYGAGLLSS GEL H+LS E ++ FDP T Q T+Q YF + SF DAKDK+R +A I++PF V ++PYT I+ LDS ++ ++ ++ EL T+T AL
Sbjct: 97 LSRALKVFETFEAKIHHLETRPAQRPLAGSPHLEYFVRFEVPSGDLAALLSSVRRVSDDVRSARE---------------------------------------DKVPWFPRKVSELDKCHHLVTKFDPDLDLDHPGFSDQAYRQRRKLIAEIAFQYKQGEPIPHVEYTKEEIATWKEVYATLKGLYATHACREHLEAFQLLERYCGYREDSIPQLEDVSHFLKERTGFQLRPVAGLLSARDFLASLAFRVFQCTQYIRHASSPMHSPEPDCCHELLGHVPMLADRTFAQFSQDIGLASLGASDEEIEKLSTVYWFTVEFGLCKQNGELKAYGAGLLSSYGELLHSLSEEPEVRAFDPDTAAVQPYQDQTYQPVYFVSESFSDAKDKLRNYASRIQRPFSVKFDPYTLAIDVLDSPHTIRRSLEGVQDELHTLTQAL 494
BLAST of tph vs. UniProt/SwissProt
Match: sp|P70080|TPH1_CHICK (Tryptophan 5-hydroxylase 1 OS=Gallus gallus OX=9031 GN=TPH1 PE=1 SV=1) HSP 1 Score: 587.8 bits (1514), Expect = 0.000e+0 Identity = 274/463 (59.18%), Postives = 350/463 (75.59%), Query Frame = 3
Query: 312 EENKTISTRRS-TSFIFGVNDNVKGLVRVLEIFEKFRVSVIHIETRKSLKNKSKFEIFIDVDCRKDEIKSLIECLQQKIDDDFHVQEVDMISSNINGIRIDTFDLAASEIGEQNIQLKNKKPGMTVDNLPWFPKYIKDLDKISNRVIMYGSELDADHPGFKDEVYRLRRNQFSEIAYSYKHGNPIPKIEYTNEEIKTWGNVYRELTKLYPTHACREFLQNLPLLQKYCGYREDNIPQLEDVSQFLKSRSGFTLRPVAGYLSSRDFLAGLAFRVFHCTQYIRHPSDPFYTPEPDCCHELMGHVPLLADSSFAQFSQEIGLASLGASEDEVQRLATCYFFTIEFGLCHQDGELRAYGAGLLSSIGELKHALSNESNIQKFDPKTVMEQECLVTTFQNAYFFTTSFEDAKDKMREFAKTIKKPFDVHYNPYTQMIETLDSTDSLTNVIDNIKGELATITNALRKFN 1697
+ENK + R T+ IF + + V GLV+ L++F++ V+++HIE+RKS + S+FEIF+D D ++++ + + L+ HV V M + ++ D ++N+PW+PK I DLDK +NRV+MYGS+LDADHPGFKD VYR RR F+++A +YKHG+PIP+IE+T EEIKTWG VYREL KLYPTHACRE+L+NLPLL KYCGYREDNIPQLEDVS+FLK R+GFT+RPVAGYLS RDFLAGLAFRVFHCTQY+RH SDP YTPEPD CHEL+GHVPLLA+ SFAQFSQEIGLASLGAS++ VQ+LATCYFFT+EFGLC Q+G+LR YGAGLLSSI ELKH+LS + ++ FDPK +QECL+TTFQ YF + SFE+AK+KMREFAKTIK+PF V YNPYTQ ++ L T S+ +V++ ++ EL +++AL K
Sbjct: 6 KENKDHAPERGRTAIIFSLKNEVGGLVKALKLFQEKHVNLVHIESRKSKRRNSEFEIFVDCDSNREQLNEIFQLLKS------HVSIVSMNPTEHFNVQEDG----------------------DMENIPWYPKKISDLDKCANRVLMYGSDLDADHPGFKDNVYRKRRKYFADLAMNYKHGDPIPEIEFTEEEIKTWGTVYRELNKLYPTHACREYLKNLPLLTKYCGYREDNIPQLEDVSRFLKERTGFTIRPVAGYLSPRDFLAGLAFRVFHCTQYVRHSSDPLYTPEPDTCHELLGHVPLLAEPSFAQFSQEIGLASLGASDEAVQKLATCYFFTVEFGLCKQEGQLRVYGAGLLSSISELKHSLSGSAKVKPFDPKVTCKQECLITTFQEVYFVSESFEEAKEKMREFAKTIKRPFGVKYNPYTQSVQILKDTKSIASVVNELRHELDIVSDALSKMG 440
BLAST of tph vs. UniProt/SwissProt
Match: sp|P17752|TPH1_HUMAN (Tryptophan 5-hydroxylase 1 OS=Homo sapiens OX=9606 GN=TPH1 PE=1 SV=4) HSP 1 Score: 584.334 bits (1505), Expect = 0.000e+0 Identity = 278/461 (60.30%), Postives = 352/461 (76.36%), Query Frame = 3
Query: 312 EENKTISTRRS-TSFIFGVNDNVKGLVRVLEIFEKFRVSVIHIETRKSLKNKSKFEIFIDVDCRKDEIKSLIECLQQKIDDDFHVQEVDMISSNINGIRIDTFDLAASEIGEQNIQLKNKKPGMTVDNLPWFPKYIKDLDKISNRVIMYGSELDADHPGFKDEVYRLRRNQFSEIAYSYKHGNPIPKIEYTNEEIKTWGNVYRELTKLYPTHACREFLQNLPLLQKYCGYREDNIPQLEDVSQFLKSRSGFTLRPVAGYLSSRDFLAGLAFRVFHCTQYIRHPSDPFYTPEPDCCHELMGHVPLLADSSFAQFSQEIGLASLGASEDEVQRLATCYFFTIEFGLCHQDGELRAYGAGLLSSIGELKHALSNESNIQKFDPKTVMEQECLVTTFQNAYFFTTSFEDAKDKMREFAKTIKKPFDVHYNPYTQMIETLDSTDSLTNVIDNIKGELATITNALRK 1691
+ENK S R S IF + + V GL++ L+IF++ V+++HIE+RKS + S+FEIF+D D ++++ +D FH ++ S+ N + ++ D N LK GM + +PWFPK I DLD +NRV+MYGSELDADHPGFKD VYR RR F+++A +YKHG+PIPK+E+T EEIKTWG V++EL KLYPTHACRE+L+NLPLL KYCGYREDNIPQLEDVS FLK R+GF++RPVAGYLS RDFL+GLAFRVFHCTQY+RH SDPFYTPEPD CHEL+GHVPLLA+ SFAQFSQEIGLASLGASE+ VQ+LATCYFFT+EFGLC QDG+LR +GAGLLSSI ELKHALS + ++ FDPK +QECL+TTFQ+ YF + SFEDAK+KMREF KTIK+PF V YNPYT+ I+ L T S+T+ ++ ++ +L +++AL K
Sbjct: 6 KENKDHSLERGRASLIFSLKNEVGGLIKALKIFQEKHVNLLHIESRKSKRRNSEFEIFVDCDINREQL-----------NDIFH-----LLKSHTNVLSVNLPD---------NFTLKED--GM--ETVPWFPKKISDLDHCANRVLMYGSELDADHPGFKDNVYRKRRKYFADLAMNYKHGDPIPKVEFTEEEIKTWGTVFQELNKLYPTHACREYLKNLPLLSKYCGYREDNIPQLEDVSNFLKERTGFSIRPVAGYLSPRDFLSGLAFRVFHCTQYVRHSSDPFYTPEPDTCHELLGHVPLLAEPSFAQFSQEIGLASLGASEEAVQKLATCYFFTVEFGLCKQDGQLRVFGAGLLSSISELKHALSGHAKVKPFDPKITCKQECLITTFQDVYFVSESFEDAKEKMREFTKTIKRPFGVKYNPYTRSIQILKDTKSITSAMNELQHDLDVVSDALAK 437
BLAST of tph vs. UniProt/SwissProt
Match: sp|P17532|TPH1_MOUSE (Tryptophan 5-hydroxylase 1 OS=Mus musculus OX=10090 GN=Tph1 PE=2 SV=1) HSP 1 Score: 582.793 bits (1501), Expect = 0.000e+0 Identity = 274/461 (59.44%), Postives = 351/461 (76.14%), Query Frame = 3
Query: 312 EENKTISTRRS-TSFIFGVNDNVKGLVRVLEIFEKFRVSVIHIETRKSLKNKSKFEIFIDVDCRKDEIKSLIECLQQKIDDDFHVQEVDMISSNINGIRIDTFDLAASEIGEQNIQLKNKKPGMTVDNLPWFPKYIKDLDKISNRVIMYGSELDADHPGFKDEVYRLRRNQFSEIAYSYKHGNPIPKIEYTNEEIKTWGNVYRELTKLYPTHACREFLQNLPLLQKYCGYREDNIPQLEDVSQFLKSRSGFTLRPVAGYLSSRDFLAGLAFRVFHCTQYIRHPSDPFYTPEPDCCHELMGHVPLLADSSFAQFSQEIGLASLGASEDEVQRLATCYFFTIEFGLCHQDGELRAYGAGLLSSIGELKHALSNESNIQKFDPKTVMEQECLVTTFQNAYFFTTSFEDAKDKMREFAKTIKKPFDVHYNPYTQMIETLDSTDSLTNVIDNIKGELATITNALRK 1691
+ENK S+ R + IF + + V GL++VL+IF++ VS++HIE+RKS + S+FEIF+D D ++++ + L+ S+ + +D+ D QL K+ M + +PWFPK I DLD +NRV++YGSELDADHPGFKD VYR RR F+E+A +YKHG+PIPKIE+T EEIKTWG ++REL KLYPTHACRE+L+NLPLL KYCGYREDNIPQLEDVS FLK R+GF++RPVAGYLS RDFL+GLAFRVFHCTQY+RH SDP YTPEPD CHEL+GHVPLLA+ SFAQFSQEIGLASLGASE+ VQ+LATCYFFT+EFGLC QDG+LR +GAGLLSSI ELKHALS + ++ FDPK +QECL+T+FQ+ YF + SFEDAK+KMREFAKT+K+PF + YNPYTQ ++ L T S+T+ ++ ++ +L I++AL +
Sbjct: 9 KENKDHSSERGRVTLIFSLENEVGGLIKVLKIFQENHVSLLHIESRKSKQRNSEFEIFVDCDISREQLNDIFPLLK----------------SHATVLSVDSPD-----------QLTAKEDVM--ETVPWFPKKISDLDFCANRVLLYGSELDADHPGFKDNVYRRRRKYFAELAMNYKHGDPIPKIEFTEEEIKTWGTIFRELNKLYPTHACREYLRNLPLLSKYCGYREDNIPQLEDVSNFLKERTGFSIRPVAGYLSPRDFLSGLAFRVFHCTQYVRHSSDPLYTPEPDTCHELLGHVPLLAEPSFAQFSQEIGLASLGASEETVQKLATCYFFTVEFGLCKQDGQLRVFGAGLLSSISELKHALSGHAKVKPFDPKIACKQECLITSFQDVYFVSESFEDAKEKMREFAKTVKRPFGLKYNPYTQSVQVLRDTKSITSAMNELRYDLDVISDALAR 440
BLAST of tph vs. UniProt/SwissProt
Match: sp|P17290|TPH1_RABIT (Tryptophan 5-hydroxylase 1 OS=Oryctolagus cuniculus OX=9986 GN=TPH1 PE=1 SV=2) HSP 1 Score: 581.637 bits (1498), Expect = 0.000e+0 Identity = 275/461 (59.65%), Postives = 351/461 (76.14%), Query Frame = 3
Query: 312 EENKTISTRRS-TSFIFGVNDNVKGLVRVLEIFEKFRVSVIHIETRKSLKNKSKFEIFIDVDCRKDEIKSLIECLQQKIDDDFHVQEVDMISSNINGIRIDTFDLAASEIGEQNIQLKNKKPGMTVDNLPWFPKYIKDLDKISNRVIMYGSELDADHPGFKDEVYRLRRNQFSEIAYSYKHGNPIPKIEYTNEEIKTWGNVYRELTKLYPTHACREFLQNLPLLQKYCGYREDNIPQLEDVSQFLKSRSGFTLRPVAGYLSSRDFLAGLAFRVFHCTQYIRHPSDPFYTPEPDCCHELMGHVPLLADSSFAQFSQEIGLASLGASEDEVQRLATCYFFTIEFGLCHQDGELRAYGAGLLSSIGELKHALSNESNIQKFDPKTVMEQECLVTTFQNAYFFTTSFEDAKDKMREFAKTIKKPFDVHYNPYTQMIETLDSTDSLTNVIDNIKGELATITNALRK 1691
+ENK S R + IF + + V GL++ L+IF++ V+++HIE+RKS + S+FEIF+D D ++++ +D FH ++ S+ N + + D N +K + GM +++PWFPK I DLD +NRV+MYGSELDADHPGFKD VYR RR F+++A SYK+G+PIPK+E+T EEIKTWG V+REL KLYPTHACRE+L+NLPLL KYCGYREDNIPQLED+S FLK R+GF++RPVAGYLS RDFL+GLAFRVFHCTQY+RH SDPFYTPEPD CHEL+GHVPLLA+ SFAQFSQEIGLASLGASE+ VQ+LATCYFFT+EFGLC QDG+LR +GAGLLSSI ELKH LS + ++ FDPK +QECL+TTFQ+ YF + SFEDAK+KMREF KTIK+PF V YNPYT+ I+ L S+TN ++ ++ +L +++AL K
Sbjct: 6 KENKDHSLERGRATLIFSLKNEVGGLIKALKIFQEKHVNLLHIESRKSKRRNSEFEIFVDCDTNREQL-----------NDIFH-----LLKSHTNVLSVTPPD---------NFTMKEE--GM--ESVPWFPKKISDLDHCANRVLMYGSELDADHPGFKDNVYRKRRKYFADLAMSYKYGDPIPKVEFTEEEIKTWGTVFRELNKLYPTHACREYLKNLPLLSKYCGYREDNIPQLEDISNFLKERTGFSIRPVAGYLSPRDFLSGLAFRVFHCTQYVRHSSDPFYTPEPDTCHELLGHVPLLAEPSFAQFSQEIGLASLGASEEAVQKLATCYFFTVEFGLCKQDGQLRVFGAGLLSSISELKHVLSGHAKVKPFDPKITYKQECLITTFQDVYFVSESFEDAKEKMREFTKTIKRPFGVKYNPYTRSIQILKDAKSITNAMNELRHDLDVVSDALGK 437
BLAST of tph vs. UniProt/SwissProt
Match: sp|P09810|TPH1_RAT (Tryptophan 5-hydroxylase 1 OS=Rattus norvegicus OX=10116 GN=Tph1 PE=2 SV=2) HSP 1 Score: 578.556 bits (1490), Expect = 0.000e+0 Identity = 270/461 (58.57%), Postives = 349/461 (75.70%), Query Frame = 3
Query: 312 EENKTISTRRS-TSFIFGVNDNVKGLVRVLEIFEKFRVSVIHIETRKSLKNKSKFEIFIDVDCRKDEIKSLIECLQQKIDDDFHVQEVDMISSNINGIRIDTFDLAASEIGEQNIQLKNKKPGMTVDNLPWFPKYIKDLDKISNRVIMYGSELDADHPGFKDEVYRLRRNQFSEIAYSYKHGNPIPKIEYTNEEIKTWGNVYRELTKLYPTHACREFLQNLPLLQKYCGYREDNIPQLEDVSQFLKSRSGFTLRPVAGYLSSRDFLAGLAFRVFHCTQYIRHPSDPFYTPEPDCCHELMGHVPLLADSSFAQFSQEIGLASLGASEDEVQRLATCYFFTIEFGLCHQDGELRAYGAGLLSSIGELKHALSNESNIQKFDPKTVMEQECLVTTFQNAYFFTTSFEDAKDKMREFAKTIKKPFDVHYNPYTQMIETLDSTDSLTNVIDNIKGELATITNALRK 1691
+ENK S+ R + IF + + V GL++ L+IF++ V+++HIE+RKS + S+FEIF+D D ++++ + L+ S+ + +D+ D QL K+ M + +PWFPK I DLD +NRV++YGSELDADHPGFKD VYR RR F+E+A +YKHG+PIPKIE+T EEIKTWG ++REL KLYPTHACRE+L+NLPLL KYCGYREDN+PQLEDVS FLK R+GF++RPVAGYLS RDFL+GLAFRVFHCTQY+RH SDP YTPEPD CHEL+GHVPLLA+ SFAQFSQEIGLASLGASE+ VQ+LATCYFFT+EFGLC QDG+LR +GAGLLSSI EL+HALS + ++ FDPK +QECL+T+FQ+ YF + SFEDAK+KMREFAKT+K+PF V YNPYTQ I+ L + S+T+ ++ ++ +L + +AL +
Sbjct: 6 KENKDHSSERGRVTLIFSLKNEVGGLIKALKIFQENHVNLLHIESRKSKRRNSEFEIFVDCDINREQLNDIFPLLK----------------SHTTVLSVDSPD-----------QLPEKEDVM--ETVPWFPKKISDLDFCANRVLLYGSELDADHPGFKDNVYRRRRKYFAELAMNYKHGDPIPKIEFTEEEIKTWGTIFRELNKLYPTHACREYLRNLPLLSKYCGYREDNVPQLEDVSNFLKERTGFSIRPVAGYLSPRDFLSGLAFRVFHCTQYVRHSSDPLYTPEPDTCHELLGHVPLLAEPSFAQFSQEIGLASLGASEETVQKLATCYFFTVEFGLCKQDGQLRVFGAGLLSSISELRHALSGHAKVKPFDPKVACKQECLITSFQDVYFVSESFEDAKEKMREFAKTVKRPFGVKYNPYTQSIQVLRDSKSITSAMNELRHDLDVVNDALAR 437
BLAST of tph vs. TrEMBL
Match: S5WES1 (Tph OS=Schmidtea mediterranea OX=79327 PE=2 SV=1) HSP 1 Score: 1135.17 bits (2935), Expect = 0.000e+0 Identity = 545/545 (100.00%), Postives = 545/545 (100.00%), Query Frame = 3
Query: 108 MSDREKEKVSNKRNSIISLTKAKSVGESSIQINTAKTRRGRFSSVSSMIDEEDFEIIKGELFDLNIVMEENKTISTRRSTSFIFGVNDNVKGLVRVLEIFEKFRVSVIHIETRKSLKNKSKFEIFIDVDCRKDEIKSLIECLQQKIDDDFHVQEVDMISSNINGIRIDTFDLAASEIGEQNIQLKNKKPGMTVDNLPWFPKYIKDLDKISNRVIMYGSELDADHPGFKDEVYRLRRNQFSEIAYSYKHGNPIPKIEYTNEEIKTWGNVYRELTKLYPTHACREFLQNLPLLQKYCGYREDNIPQLEDVSQFLKSRSGFTLRPVAGYLSSRDFLAGLAFRVFHCTQYIRHPSDPFYTPEPDCCHELMGHVPLLADSSFAQFSQEIGLASLGASEDEVQRLATCYFFTIEFGLCHQDGELRAYGAGLLSSIGELKHALSNESNIQKFDPKTVMEQECLVTTFQNAYFFTTSFEDAKDKMREFAKTIKKPFDVHYNPYTQMIETLDSTDSLTNVIDNIKGELATITNALRKFNIFWHGTQMAQINNSN 1742
MSDREKEKVSNKRNSIISLTKAKSVGESSIQINTAKTRRGRFSSVSSMIDEEDFEIIKGELFDLNIVMEENKTISTRRSTSFIFGVNDNVKGLVRVLEIFEKFRVSVIHIETRKSLKNKSKFEIFIDVDCRKDEIKSLIECLQQKIDDDFHVQEVDMISSNINGIRIDTFDLAASEIGEQNIQLKNKKPGMTVDNLPWFPKYIKDLDKISNRVIMYGSELDADHPGFKDEVYRLRRNQFSEIAYSYKHGNPIPKIEYTNEEIKTWGNVYRELTKLYPTHACREFLQNLPLLQKYCGYREDNIPQLEDVSQFLKSRSGFTLRPVAGYLSSRDFLAGLAFRVFHCTQYIRHPSDPFYTPEPDCCHELMGHVPLLADSSFAQFSQEIGLASLGASEDEVQRLATCYFFTIEFGLCHQDGELRAYGAGLLSSIGELKHALSNESNIQKFDPKTVMEQECLVTTFQNAYFFTTSFEDAKDKMREFAKTIKKPFDVHYNPYTQMIETLDSTDSLTNVIDNIKGELATITNALRKFNIFWHGTQMAQINNSN
Sbjct: 1 MSDREKEKVSNKRNSIISLTKAKSVGESSIQINTAKTRRGRFSSVSSMIDEEDFEIIKGELFDLNIVMEENKTISTRRSTSFIFGVNDNVKGLVRVLEIFEKFRVSVIHIETRKSLKNKSKFEIFIDVDCRKDEIKSLIECLQQKIDDDFHVQEVDMISSNINGIRIDTFDLAASEIGEQNIQLKNKKPGMTVDNLPWFPKYIKDLDKISNRVIMYGSELDADHPGFKDEVYRLRRNQFSEIAYSYKHGNPIPKIEYTNEEIKTWGNVYRELTKLYPTHACREFLQNLPLLQKYCGYREDNIPQLEDVSQFLKSRSGFTLRPVAGYLSSRDFLAGLAFRVFHCTQYIRHPSDPFYTPEPDCCHELMGHVPLLADSSFAQFSQEIGLASLGASEDEVQRLATCYFFTIEFGLCHQDGELRAYGAGLLSSIGELKHALSNESNIQKFDPKTVMEQECLVTTFQNAYFFTTSFEDAKDKMREFAKTIKKPFDVHYNPYTQMIETLDSTDSLTNVIDNIKGELATITNALRKFNIFWHGTQMAQINNSN 545
BLAST of tph vs. TrEMBL
Match: A7VKD9 (Tryptophan hydroxylase OS=Dugesia japonica OX=6161 GN=DjTPH PE=2 SV=1) HSP 1 Score: 994.186 bits (2569), Expect = 0.000e+0 Identity = 475/545 (87.16%), Postives = 510/545 (93.58%), Query Frame = 3
Query: 108 MSDREKEKVSNKRNSIISLTKAKSVGESSIQINTAKTRRGRFSSVSSMIDEEDFEIIKGELFDLNIVMEENKTISTRRSTSFIFGVNDNVKGLVRVLEIFEKFRVSVIHIETRKSLKNKSKFEIFIDVDCRKDEIKSLIECLQQKIDDDFHVQEVDMISSNINGIRIDTFDLAASEIGEQN-IQLKNKKPGMTVDNLPWFPKYIKDLDKISNRVIMYGSELDADHPGFKDEVYRLRRNQFSEIAYSYKHGNPIPKIEYTNEEIKTWGNVYRELTKLYPTHACREFLQNLPLLQKYCGYREDNIPQLEDVSQFLKSRSGFTLRPVAGYLSSRDFLAGLAFRVFHCTQYIRHPSDPFYTPEPDCCHELMGHVPLLADSSFAQFSQEIGLASLGASEDEVQRLATCYFFTIEFGLCHQDGELRAYGAGLLSSIGELKHALSNESNIQKFDPKTVMEQECLVTTFQNAYFFTTSFEDAKDKMREFAKTIKKPFDVHYNPYTQMIETLDSTDSLTNVIDNIKGELATITNALRKFNIFWHGTQMAQINNS 1739
M +R+K NK+NSIISLTKAKSV E+ IQIN+AK RRGRFSSVSSMIDEEDFEIIKGEL DLNIVMEENK+ISTRRSTSFIFGVNDNVKGLVRVLEIFEKF VSVIHIETRKSLKNKSKFEIFIDVDC+KDEIKSLI+CL+Q +D+DFHVQEVDMISSN NGI+ D+ D +E +QN IQ+K KK MTVDNLPWFPKYIKDLDKISNRVIMYGSELDADHPGFKDE+YR RRNQFSEIAYSYKHGNPIPKIEYT +EI TWGNVYRELTKLYPTHACREFL+NLPLLQKYCGYREDNIPQLE+VSQFLK+RSGFTLRPVAGYLSSRDFLAGLAFRVFHCTQYIRHPSDPFYTPEPDCCHELMGHVPLLADSSFAQFSQEIGLASLGASE+EVQ+LATCYFFTIEFGLCHQDGELRAYGAGLLSSIGELKHALS ESNIQKFDPK VMEQECLVTTFQNAYF+T SFEDAKDKMR+FAKTIKKPFDVHYNPYTQMIE LDSTDS+T+VI+NIKGELATITNAL+K NI+W+G+ ++ + S
Sbjct: 1 MCERDKVFAENKKNSIISLTKAKSVSENLIQINSAKHRRGRFSSVSSMIDEEDFEIIKGELLDLNIVMEENKSISTRRSTSFIFGVNDNVKGLVRVLEIFEKFEVSVIHIETRKSLKNKSKFEIFIDVDCKKDEIKSLIKCLEQNVDNDFHVQEVDMISSNPNGIKCDSADRPNNESLDQNQIQIKAKKRAMTVDNLPWFPKYIKDLDKISNRVIMYGSELDADHPGFKDELYRKRRNQFSEIAYSYKHGNPIPKIEYTKDEITTWGNVYRELTKLYPTHACREFLENLPLLQKYCGYREDNIPQLEEVSQFLKNRSGFTLRPVAGYLSSRDFLAGLAFRVFHCTQYIRHPSDPFYTPEPDCCHELMGHVPLLADSSFAQFSQEIGLASLGASEEEVQKLATCYFFTIEFGLCHQDGELRAYGAGLLSSIGELKHALSTESNIQKFDPKLVMEQECLVTTFQNAYFYTPSFEDAKDKMRDFAKTIKKPFDVHYNPYTQMIEILDSTDSVTSVIENIKGELATITNALKKLNIYWYGSHRSEADQS 545
BLAST of tph vs. TrEMBL
Match: F6KBQ2 (Tryptophan hydroxylase (Fragment) OS=Schmidtea mediterranea OX=79327 GN=tph PE=2 SV=1) HSP 1 Score: 805.053 bits (2078), Expect = 0.000e+0 Identity = 380/380 (100.00%), Postives = 380/380 (100.00%), Query Frame = 3
Query: 489 VDCRKDEIKSLIECLQQKIDDDFHVQEVDMISSNINGIRIDTFDLAASEIGEQNIQLKNKKPGMTVDNLPWFPKYIKDLDKISNRVIMYGSELDADHPGFKDEVYRLRRNQFSEIAYSYKHGNPIPKIEYTNEEIKTWGNVYRELTKLYPTHACREFLQNLPLLQKYCGYREDNIPQLEDVSQFLKSRSGFTLRPVAGYLSSRDFLAGLAFRVFHCTQYIRHPSDPFYTPEPDCCHELMGHVPLLADSSFAQFSQEIGLASLGASEDEVQRLATCYFFTIEFGLCHQDGELRAYGAGLLSSIGELKHALSNESNIQKFDPKTVMEQECLVTTFQNAYFFTTSFEDAKDKMREFAKTIKKPFDVHYNPYTQMIETLDSTDS 1628
VDCRKDEIKSLIECLQQKIDDDFHVQEVDMISSNINGIRIDTFDLAASEIGEQNIQLKNKKPGMTVDNLPWFPKYIKDLDKISNRVIMYGSELDADHPGFKDEVYRLRRNQFSEIAYSYKHGNPIPKIEYTNEEIKTWGNVYRELTKLYPTHACREFLQNLPLLQKYCGYREDNIPQLEDVSQFLKSRSGFTLRPVAGYLSSRDFLAGLAFRVFHCTQYIRHPSDPFYTPEPDCCHELMGHVPLLADSSFAQFSQEIGLASLGASEDEVQRLATCYFFTIEFGLCHQDGELRAYGAGLLSSIGELKHALSNESNIQKFDPKTVMEQECLVTTFQNAYFFTTSFEDAKDKMREFAKTIKKPFDVHYNPYTQMIETLDSTDS
Sbjct: 1 VDCRKDEIKSLIECLQQKIDDDFHVQEVDMISSNINGIRIDTFDLAASEIGEQNIQLKNKKPGMTVDNLPWFPKYIKDLDKISNRVIMYGSELDADHPGFKDEVYRLRRNQFSEIAYSYKHGNPIPKIEYTNEEIKTWGNVYRELTKLYPTHACREFLQNLPLLQKYCGYREDNIPQLEDVSQFLKSRSGFTLRPVAGYLSSRDFLAGLAFRVFHCTQYIRHPSDPFYTPEPDCCHELMGHVPLLADSSFAQFSQEIGLASLGASEDEVQRLATCYFFTIEFGLCHQDGELRAYGAGLLSSIGELKHALSNESNIQKFDPKTVMEQECLVTTFQNAYFFTTSFEDAKDKMREFAKTIKKPFDVHYNPYTQMIETLDSTDS 380
BLAST of tph vs. TrEMBL
Match: A0A267EVM7 (Uncharacterized protein OS=Macrostomum lignano OX=282301 GN=BOX15_Mlig017249g1 PE=4 SV=1) HSP 1 Score: 635.18 bits (1637), Expect = 0.000e+0 Identity = 307/533 (57.60%), Postives = 389/533 (72.98%), Query Frame = 3
Query: 207 TAKTRRGRFSSVSSMIDEEDFEIIKGELFDLNIVMEENKTISTRRSTSFIFGVNDNVKGLVRVLEIFEKFRVSVIHIETRKSLKNKSKFEIFIDVDCRKDEIKSLIECLQQKIDDDFHVQEVD-----------------MISSNINGIRIDTFD---------LAASEI-GEQN-IQLKNKKP--------GMTVDNLPWFPKYIKDLDKISNRVIMYGSELDADHPGFKDEVYRLRRNQFSEIAYSYKHGNPIPKIEYTNEEIKTWGNVYRELTKLYPTHACREFLQNLPLLQKYCGYREDNIPQLEDVSQFLKSRSGFTLRPVAGYLSSRDFLAGLAFRVFHCTQYIRHPSDPFYTPEPDCCHELMGHVPLLADSSFAQFSQEIGLASLGASEDEVQRLATCYFFTIEFGLCHQDGELRAYGAGLLSSIGELKHALSNESNIQKFDPKTVMEQECLVTTFQNAYFFTTSFEDAKDKMREFAKTIKKPFDVHYNPYTQMIETLDSTDSLTNVIDNIKGELATITNALRKFN 1697
AK RRGRFSSVSSMIDE+D I+ +L DL V E + + +++ SFIFGV D + GL VL+IFE + V+H+E+R + + FEIF+DVD + ++ SL++ L+ +++ VQEVD I N +D D + +EI G+ N K P MT++ LPWFP+ I+DLDK+S RVIMYGSELDADHPGFKD YR RR F+++AY+Y+ G PIP+IEYT EE +TW VY+EL+ LY HACREFL+NLP LQK+CGYREDNIPQLED+S++LK R+GF LRPVAGYLS+RDFL+GLAFRVFHCTQYIRH +DPFYTPEPDCCHE++GH+PLLAD SFAQFSQEIGLASLGAS++EVQ+LATCYFFTIEFGLC Q+GE++ YGAGLLS + E + +S ++ I FDP+TV ++ECLVTTFQN YF+T SFEDAK+KMREFAKTI++PFDV YNPYTQ +E LDS + NV++ +KG+LA I++ALRK
Sbjct: 5 AAKARRGRFSSVSSMIDEDDISGIENKLKDLGSVKETAE--AAKKTVSFIFGVGDRISGLAGVLKIFEANNIEVVHVESRGGRRASAPFEIFVDVDADRSKLPSLVDALKAEVES-VMVQEVDKSIDPDQTESGAAISGGGIGGGANDEAVDGGDAFENSGPAGVVDTEIPGKSNPASTKTSAPRQGRMLRRQMTMERLPWFPRRIQDLDKVSRRVIMYGSELDADHPGFKDVEYRKRRMWFADLAYNYRQGEPIPRIEYTAEETRTWAAVYKELSSLYQKHACREFLENLPQLQKFCGYREDNIPQLEDISRYLKDRTGFVLRPVAGYLSARDFLSGLAFRVFHCTQYIRHGADPFYTPEPDCCHEILGHMPLLADPSFAQFSQEIGLASLGASDEEVQKLATCYFFTIEFGLCKQEGEMKVYGAGLLSCVDEFRFVMSGKAEINSFDPRTVSKEECLVTTFQNRYFYTPSFEDAKEKMREFAKTIRRPFDVRYNPYTQSVEVLDSPRRIANVVNELKGDLAIISSALRKMT 534
BLAST of tph vs. TrEMBL
Match: A0A1I8I7A2 (Uncharacterized protein OS=Macrostomum lignano OX=282301 GN=BOX15_Mlig010937g1 PE=4 SV=1) HSP 1 Score: 633.639 bits (1633), Expect = 0.000e+0 Identity = 303/533 (56.85%), Postives = 386/533 (72.42%), Query Frame = 3
Query: 207 TAKTRRGRFSSVSSMIDEEDFEIIKGELFDLNIVMEENKTISTRRSTSFIFGVNDNVKGLVRVLEIFEKFRVSVIHIETRKSLKNKSKFEIFIDVDCRKDEIKSLIECLQQKIDDDFHVQEVD---------------------------------MISSNINGI---RIDTFDLAASEIGEQNIQLKNKKPGMTVDNLPWFPKYIKDLDKISNRVIMYGSELDADHPGFKDEVYRLRRNQFSEIAYSYKHGNPIPKIEYTNEEIKTWGNVYRELTKLYPTHACREFLQNLPLLQKYCGYREDNIPQLEDVSQFLKSRSGFTLRPVAGYLSSRDFLAGLAFRVFHCTQYIRHPSDPFYTPEPDCCHELMGHVPLLADSSFAQFSQEIGLASLGASEDEVQRLATCYFFTIEFGLCHQDGELRAYGAGLLSSIGELKHALSNESNIQKFDPKTVMEQECLVTTFQNAYFFTTSFEDAKDKMREFAKTIKKPFDVHYNPYTQMIETLDSTDSLTNVIDNIKGELATITNALRKFN 1697
AK RRGRFSSVSSMIDE++ I+ +L DL V E + + +++ SFIFGV D + GL VL+IFE + V+H+E+R + + FEIF+DVD + ++ SL++ L+ +++ VQEVD +S G+ I AAS Q + + MT++ LPWFP+ I+DLDK+S RVIMYGSELDADHPGFKD YR RR F+++AY+Y+ G PIP+IEYT EE +TW VY+EL+ LY HACREFL+NLP LQK+CGYREDNIPQLED+S++LK R+GF LRPVAGYLS+RDFL+GLAFRVFHCTQYIRH +DPFYTPEPDCCHE++GH+PLLAD SFAQFSQEIGLASLGAS++EVQ+LATCYFFTIEFGLC Q+GE++ YGAGLLS + E + +S ++ I FDP+TV ++ECLVTTFQN YF+T SFEDAK+KMREFAKTI++PFDV YNPYTQ +E LDS + NV++ +KG+LA I++ALRK
Sbjct: 5 AAKARRGRFSSVSSMIDEDEISGIENKLKDLGSVKETAE--AAKKTVSFIFGVGDRISGLAGVLKIFEANNIEVVHVESRGGRRASAPFEIFVDVDADRSKLPSLVDALKAEVES-VMVQEVDKSIDPDQTESGAAISGGGVGGGANDGAVDGGNAFENSGPAGVVDTEIPGKSNAASAKTSAPRQGRMLRRQMTMERLPWFPRRIQDLDKVSRRVIMYGSELDADHPGFKDVEYRKRRMWFADLAYNYRQGEPIPRIEYTAEETRTWAAVYKELSSLYQKHACREFLENLPQLQKFCGYREDNIPQLEDISRYLKDRTGFVLRPVAGYLSARDFLSGLAFRVFHCTQYIRHGADPFYTPEPDCCHEILGHMPLLADPSFAQFSQEIGLASLGASDEEVQKLATCYFFTIEFGLCKQEGEMKVYGAGLLSCVDEFRFVMSGKAEINSFDPRTVSKEECLVTTFQNRYFYTPSFEDAKEKMREFAKTIRRPFDVRYNPYTQSVEVLDSPRRIANVVNELKGDLAIISSALRKMT 534
BLAST of tph vs. Ensembl Cavefish
Match: tph1a (tryptophan hydroxylase 1 [Source:NCBI gene;Acc:103043966]) HSP 1 Score: 581.252 bits (1497), Expect = 0.000e+0 Identity = 271/463 (58.53%), Postives = 349/463 (75.38%), Query Frame = 3
Query: 312 EENKTISTRRS-TSFIFGVNDNVKGLVRVLEIFEKFRVSVIHIETRKSLKNKSKFEIFIDVDCRKDEIKSLIECLQQKIDDDFHVQEVDMISSNINGIRIDTFDLAASEIGEQNIQLKNKKPGMTVDNLPWFPKYIKDLDKISNRVIMYGSELDADHPGFKDEVYRLRRNQFSEIAYSYKHGNPIPKIEYTNEEIKTWGNVYRELTKLYPTHACREFLQNLPLLQKYCGYREDNIPQLEDVSQFLKSRSGFTLRPVAGYLSSRDFLAGLAFRVFHCTQYIRHPSDPFYTPEPDCCHELMGHVPLLADSSFAQFSQEIGLASLGASEDEVQRLATCYFFTIEFGLCHQDGELRAYGAGLLSSIGELKHALSNESNIQKFDPKTVMEQECLVTTFQNAYFFTTSFEDAKDKMREFAKTIKKPFDVHYNPYTQMIETLDSTDSLTNVIDNIKGELATITNALRKFN 1697
++NK+ S + + +F + + V GLV+ L++F++ V+++HIE+RKS + S+FEI +D D +++ +I+ L++ HV +D +S +K+ +DN+PWFPK I DLDK +NRV+MYGS+LDADHPGFKD VYR RR F+++A SYKHG+PIP+IE+T EE+KTWG V+REL KLYPTHACRE L+NLPLL KYCGYREDNIPQLEDVS+FL+ R+GF +RPVAGYLS RDFLAGLAFRVFHCTQY+RH SDP YTPEPD CHEL+GHVPLLA+ SFAQFSQEIGLASLGAS++ VQ+LATCYFFT+EFGLC Q+G+LRAYGAGLLSSI EL+HALS + I FDPK +QEC++TTFQ+ YF + SFE+AK KMREFAKTIK+PF V YNPYTQ ++ L T S+ +V++ ++ EL + +AL + N
Sbjct: 45 KDNKSESAEKGRAAIVFSLKNEVGGLVKALKLFQENHVNLVHIESRKSRRRNSEFEILVDCDSNHEQLNEIIQLLRK------HVNVLDTETS-----------------------IKSLPEEDEMDNVPWFPKKIADLDKCANRVLMYGSDLDADHPGFKDNVYRKRRKYFADLAMSYKHGDPIPRIEFTEEEVKTWGVVFRELNKLYPTHACREHLKNLPLLTKYCGYREDNIPQLEDVSRFLRERTGFNIRPVAGYLSPRDFLAGLAFRVFHCTQYVRHSSDPLYTPEPDTCHELLGHVPLLAEPSFAQFSQEIGLASLGASDEAVQKLATCYFFTVEFGLCKQEGKLRAYGAGLLSSISELRHALSGNARIMPFDPKVTCKQECIITTFQDVYFVSDSFEEAKVKMREFAKTIKRPFTVRYNPYTQSVDVLKDTTSINSVVEELRHELDIVGDALNRLN 478
BLAST of tph vs. Ensembl Cavefish
Match: tph2 (tryptophan hydroxylase 2 (tryptophan 5-monooxygenase) [Source:ZFIN;Acc:ZDB-GENE-040624-4]) HSP 1 Score: 564.688 bits (1454), Expect = 0.000e+0 Identity = 264/453 (58.28%), Postives = 341/453 (75.28%), Query Frame = 3
Query: 345 TSFIFGVNDNVKGLVRVLEIFEKFRVSVIHIETRKSLKNKSKFEIFIDVDCRKDEIKSLIECLQQKIDDDFHVQEVDMISSNINGIRIDTFDLAASEIGEQNIQLKNKKPGMTVDNLPWFPKYIKDLDKISNRVIMYGSELDADHPGFKDEVYRLRRNQFSEIAYSYKHGNPIPKIEYTNEEIKTWGNVYRELTKLYPTHACREFLQNLPLLQKYCGYREDNIPQLEDVSQFLKSRSGFTLRPVAGYLSSRDFLAGLAFRVFHCTQYIRHPSDPFYTPEPDCCHELMGHVPLLADSSFAQFSQEIGLASLGASEDEVQRLATCYFFTIEFGLCHQDGELRAYGAGLLSSIGELKHALSNESNIQKFDPKTVMEQECLVTTFQNAYFFTTSFEDAKDKMREFAKTIKKPFDVHYNPYTQMIETLDSTDSLTNVIDNIKGELATITNALRKFNIF 1703
T+ IF + + V LV+ L +F++ V++ HIE+RKS + ++ EI+ + +C K E L++ L+ ++ + + SS +G + +PWFP+ I +LD+ S+RV+MYGSELDADHPGFKD VYR RR F E+A +YK G PIP+I+YT EE+KTWG V+RELTKLYPTHACRE+L+NLPLL K+CGYREDNIPQLEDVS FL+ RSGF +RPVAGYLS RDFLAGLA+RVF+CTQY+RH +DP YTPEPD CHEL+GHVPLLAD FAQFSQEIGLASLGAS+++VQ+LATCYFFTIEFGLC QDG+LRAYGAGLLSSIGEL+HALS+++ ++ FDP+T QECL+TTFQ+ YF + SFE+AK+KMREFAK+IK+PF V+YNPYTQ I+ L T S+ NV+ +++ +L T+ +AL K N +
Sbjct: 20 TAVIFSLKNEVGCLVKALRLFQEKHVNLAHIESRKSKRVTTEVEIYAECNCTKKEFNELVQHLKDHVNIISYNTPQHVWSSETDG-----------------------------EGVPWFPQKISELDQCSHRVLMYGSELDADHPGFKDNVYRQRRKYFVEVAMNYKFGQPIPRIDYTLEEVKTWGVVFRELTKLYPTHACREYLKNLPLLTKHCGYREDNIPQLEDVSLFLRERSGFIVRPVAGYLSPRDFLAGLAYRVFNCTQYVRHSTDPLYTPEPDTCHELLGHVPLLADPKFAQFSQEIGLASLGASDEDVQKLATCYFFTIEFGLCKQDGQLRAYGAGLLSSIGELRHALSDKAVVKPFDPRTTCYQECLITTFQDVYFVSDSFEEAKEKMREFAKSIKRPFSVYYNPYTQSIDLLKDTRSIENVVQDLRSDLTTVCDALGKMNKY 443
BLAST of tph vs. Ensembl Cavefish
Match: tph1b (tryptophan 5-hydroxylase 1-like [Source:NCBI gene;Acc:103025693]) HSP 1 Score: 559.296 bits (1440), Expect = 0.000e+0 Identity = 269/503 (53.48%), Postives = 357/503 (70.97%), Query Frame = 3
Query: 207 TAKTRRGR-FSSVSSMIDEEDFEIIKGEL----FDLNIVMEENKTISTRRS-TSFIFGVNDNVKGLVRVLEIFEKFRVSVIHIETRKSLKNKSKFEIFIDVDCRKDEIKSLIECLQQKIDDDFHVQEVDMISSNINGIRIDTFDLAASEIGEQNIQLKNKKPGMTVDNLPWFPKYIKDLDKISNRVIMYGSELDADHPGFKDEVYRLRRNQFSEIAYSYKHGNPIPKIEYTNEEIKTWGNVYRELTKLYPTHACREFLQNLPLLQKYCGYREDNIPQLEDVSQFLKSRSGFTLRPVAGYLSSRDFLAGLAFRVFHCTQYIRHPSDPFYTPEPDCCHELMGHVPLLADSSFAQFSQEIGLASLGASEDEVQRLATCYFFTIEFGLCHQDGELRAYGAGLLSSIGELKHALSNESNIQKFDPKTVMEQECLVTTFQNAYFFTTSFEDAKDKMREFAKTIKKPFDVHYNPYTQMIETLDSTDSLTNVIDNIKGELATITNALRKFN 1697
T RRGR F S++ +E+ I EL F+ NI + + +S++R + IF + + V LV+ L++F++ +V ++HIE+RKS +N S+ E+ +D D +D +K +I+ L+++ N + +D + + P PWFP+ I DLDK +NRV+MYGS LDADHPGFKD VYR RR F+++A +YKHG IP++E+T EE++TWG V+REL KLYP HACRE+L NLPLL ++CGYRE+NIPQLEDVS+FL+ R+GFT+RPVAGYLS RDFLAGLAFRVFHCTQY+RH S P YTPEPD CHEL+GHVPLLA+ SFAQFSQE+GLASLGAS+D VQ+LATCYFFT+EFGLC Q+G+LRAYGAGLLSSI EL+HALS + I F+PK +QECL+TTFQ+ YF + SFE+AK +MREFAKTI++PF V YNPYTQ + L S+ +V++ ++ EL + +AL + N
Sbjct: 6 TEGPRRGRSFDSINKYYEEKQ---INNELNKSTFN-NIEENQGRILSSKREHAAIIFSLKNEVGNLVKALKLFQENQVKLLHIESRKSRRNNSELEVLVDCDSERDTLKEIIQLLKKQT----------------NTVTMDPPERPLPD------------PDTDFPEEPWFPRKISDLDKCANRVLMYGSALDADHPGFKDNVYRKRRKYFADLAMNYKHGEAIPRVEFTEEEVRTWGVVFRELNKLYPCHACREYLLNLPLLSQHCGYRENNIPQLEDVSRFLRERTGFTIRPVAGYLSPRDFLAGLAFRVFHCTQYVRHSSAPLYTPEPDTCHELLGHVPLLAEPSFAQFSQELGLASLGASDDAVQKLATCYFFTVEFGLCKQEGKLRAYGAGLLSSISELQHALSGNAKILPFEPKVTCKQECLITTFQDVYFMSESFEEAKIRMREFAKTIRRPFTVRYNPYTQSVSVLKDMPSINSVVEELRHELDIVGDALHRLN 476
BLAST of tph vs. Ensembl Cavefish
Match: tph1a (tryptophan hydroxylase 1 [Source:NCBI gene;Acc:103043966]) HSP 1 Score: 525.013 bits (1351), Expect = 0.000e+0 Identity = 246/411 (59.85%), Postives = 312/411 (75.91%), Query Frame = 3
Query: 312 EENKTISTRRS-TSFIFGVNDNVKGLVRVLEIFEKFRVSVIHIETRKSLKNKSKFEIFIDVDCRKDEIKSLIECLQQKIDDDFHVQEVDMISSNINGIRIDTFDLAASEIGEQNIQLKNKKPGMTVDNLPWFPKYIKDLDKISNRVIMYGSELDADHPGFKDEVYRLRRNQFSEIAYSYKHGNPIPKIEYTNEEIKTWGNVYRELTKLYPTHACREFLQNLPLLQKYCGYREDNIPQLEDVSQFLKSRSGFTLRPVAGYLSSRDFLAGLAFRVFHCTQYIRHPSDPFYTPEPDCCHELMGHVPLLADSSFAQFSQEIGLASLGASEDEVQRLATCYFFTIEFGLCHQDGELRAYGAGLLSSIGELKHALSNESNIQKFDPKTVMEQECLVTTFQNAYFFTTSFEDAKDKMR 1541
++NK+ S + + +F + + V GLV+ L++F++ V+++HIE+RKS + S+FEI +D D +++ +I+ L++ HV +D +S +K+ +DN+PWFPK I DLDK +NRV+MYGS+LDADHPGFKD VYR RR F+++A SYKHG+PIP+IE+T EE+KTWG V+REL KLYPTHACRE L+NLPLL KYCGYREDNIPQLEDVS+FL+ R+GF +RPVAGYLS RDFLAGLAFRVFHCTQY+RH SDP YTPEPD CHEL+GHVPLLA+ SFAQFSQEIGLASLGAS++ VQ+LATCYFFT+EFGLC Q+G+LRAYGAGLLSSI EL+HALS + I FDPK +QEC++TTFQ+ YF + SFE+AK KMR
Sbjct: 45 KDNKSESAEKGRAAIVFSLKNEVGGLVKALKLFQENHVNLVHIESRKSRRRNSEFEILVDCDSNHEQLNEIIQLLRK------HVNVLDTETS-----------------------IKSLPEEDEMDNVPWFPKKIADLDKCANRVLMYGSDLDADHPGFKDNVYRKRRKYFADLAMSYKHGDPIPRIEFTEEEVKTWGVVFRELNKLYPTHACREHLKNLPLLTKYCGYREDNIPQLEDVSRFLRERTGFNIRPVAGYLSPRDFLAGLAFRVFHCTQYVRHSSDPLYTPEPDTCHELLGHVPLLAEPSFAQFSQEIGLASLGASDEAVQKLATCYFFTVEFGLCKQEGKLRAYGAGLLSSISELRHALSGNARIMPFDPKVTCKQECIITTFQDVYFVSDSFEEAKVKMR 426
BLAST of tph vs. Ensembl Cavefish
Match: pah (phenylalanine hydroxylase [Source:ZFIN;Acc:ZDB-GENE-031006-2]) HSP 1 Score: 461.07 bits (1185), Expect = 1.155e-158 Identity = 230/450 (51.11%), Postives = 302/450 (67.11%), Query Frame = 3
Query: 348 SFIFGVNDNVKGLVRVLEIFEKFRVSVIHIETRKSLKNKSKFEIFIDVDCRK--DEIKSLIECLQQKIDDDFHVQEVDMISSNINGIRIDTFDLAASEIGEQNIQLKNKKPGMTVDNLPWFPKYIKDLDKISNRVIMYGSELDADHPGFKDEVYRLRRNQFSEIAYSYKHGNPIPKIEYTNEEIKTWGNVYRELTKLYPTHACREFLQNLPLLQKYCGYREDNIPQLEDVSQFLKSRSGFTLRPVAGYLSSRDFLAGLAFRVFHCTQYIRHPSDPFYTPEPDCCHELMGHVPLLADSSFAQFSQEIGLASLGASEDEVQRLATCYFFTIEFGLCHQDGELRAYGAGLLSSIGELKHALSNESNIQKFDPKTVMEQECLVTTFQNAYFFTTSFEDAKDKMREFAKTIKKPFDVHYNPYTQMIETLDSTDSLTNVIDNIKGELATITNALRK 1691
S IF +N+ V L + L +FE+ +++ HIE+ V C K DE+ I+G+R +EI Q ++ K D +PWFP I+DLD+ +N+++ YGSELDADHPGF D VYR RR +F++IAY+Y+HG IP +EYT E TWG V+REL LYPTHAC E + PLL++YCGYREDNIPQLED+S++L+S +GF LRPVAG LSSRDFLAGLAFRVFH TQYIRH S+P YTPEPD CHEL+GHVPL AD SFAQFSQEIGLASL A ++ +++LAT Y+FT+EFGLC Q ++RAYGAGLLSS GEL++AL+++ + F+P+ + Q+ +T FQ YF SFED+K+K+R++A TI +PF V YN YTQ IE LD+T L N+ ++I E+ + NAL+K
Sbjct: 14 SCIFSLNEEVGSLAKALRLFEEKGINLTHIESH--------------VSCSKALDEV--------------------------IDGLR--------AEITGQVHEMSRNK---IKDTVPWFPSNIQDLDRFANQILSYGSELDADHPGFTDPVYRARRKEFADIAYNYRHGQSIPYVEYTEAEKATWGTVFRELKTLYPTHACHEHNRVFPLLEEYCGYREDNIPQLEDISRYLQSCTGFRLRPVAGLLSSRDFLAGLAFRVFHSTQYIRHGSNPMYTPEPDICHELLGHVPLFADPSFAQFSQEIGLASLAAPDEYIEKLATVYWFTVEFGLCKQGNDIRAYGAGLLSSFGELQYALTDKPKLLPFEPEKTILQKYPITEFQPIYFVAESFEDSKEKVRKYAATIPRPFSVRYNAYTQSIEVLDNTQQLRNLANSI-SEVGILCNALQK 411
BLAST of tph vs. Ensembl Sea Lamprey
Match: tph1a (tryptophan hydroxylase 1 (tryptophan 5-monooxygenase) a [Source:ZFIN;Acc:ZDB-GENE-030317-1]) HSP 1 Score: 580.867 bits (1496), Expect = 0.000e+0 Identity = 267/454 (58.81%), Postives = 345/454 (75.99%), Query Frame = 3
Query: 336 RRSTSFIFGVNDNVKGLVRVLEIFEKFRVSVIHIETRKSLKNKSKFEIFIDVDCRKDEIKSLIECLQQKIDDDFHVQEVDMISSNINGIRIDTFDLAASEIGEQNIQLKNKKPGMTVDNLPWFPKYIKDLDKISNRVIMYGSELDADHPGFKDEVYRLRRNQFSEIAYSYKHGNPIPKIEYTNEEIKTWGNVYRELTKLYPTHACREFLQNLPLLQKYCGYREDNIPQLEDVSQFLKSRSGFTLRPVAGYLSSRDFLAGLAFRVFHCTQYIRHPSDPFYTPEPDCCHELMGHVPLLADSSFAQFSQEIGLASLGASEDEVQRLATCYFFTIEFGLCHQDGELRAYGAGLLSSIGELKHALSNESNIQKFDPKTVMEQECLVTTFQNAYFFTTSFEDAKDKMREFAKTIKKPFDVHYNPYTQMIETLDSTDSLTNVIDNIKGELATITNALRKFN 1697
R + +F + +++ GLV+ L++F++ V+++HIE+RKS + S+FEI++D D ++++ L++ L+ +++S + D +G Q++ D +PWFPK I DLD SN+V+MYG++LDADHPGFKD VYR RR F++IA +YKHG PIP+IEYT EE++TW V+RELTKLYPTHACRE+L+NLPLL K+CGYR+DNIPQLEDVS+FLK RSGFT+RPVAGYLS RDFLAGLAFRVFHCTQY+RH SDP YTPEPD CHEL+GHVPLLA+ SFAQFSQEIGLASLGAS++ VQ+LATCYFFT+EFGLC QDG+LRAYGAGLLSSI ELKHALS + ++ FDPK +QECL+TTFQ+ YF + SFE+AK+KMREFAKTIK+ F V YNPYTQ IE L T + ++ ++ EL T+++AL + N
Sbjct: 54 RGRAAVVFSLKNDIGGLVKALKLFQEKHVNLMHIESRKSKRRNSEFEIYVDCDSNREQLGELMQLLRS--------HACNIVSMSGPASHCD--------VGPQDL-----------DGVPWFPKKISDLDHSSNKVLMYGADLDADHPGFKDNVYRKRRKHFADIALNYKHGEPIPRIEYTEEEVRTWATVFRELTKLYPTHACREYLKNLPLLTKHCGYRDDNIPQLEDVSRFLKERSGFTIRPVAGYLSPRDFLAGLAFRVFHCTQYVRHSSDPLYTPEPDTCHELLGHVPLLAEPSFAQFSQEIGLASLGASDEAVQKLATCYFFTVEFGLCKQDGQLRAYGAGLLSSISELKHALSENAKVKGFDPKVTCKQECLITTFQDIYFVSESFEEAKEKMREFAKTIKRNFTVRYNPYTQSIEVLKDTRMIAEMVKELRAELDTVSDALHRLN 480
BLAST of tph vs. Ensembl Sea Lamprey
Match: ENSPMAT00000000676.1 (pep scaffold:Pmarinus_7.0:GL477040:200355:204568:-1 gene:ENSPMAG00000000617.1 transcript:ENSPMAT00000000676.1 gene_biotype:protein_coding transcript_biotype:protein_coding) HSP 1 Score: 327.405 bits (838), Expect = 5.423e-109 Identity = 148/281 (52.67%), Postives = 197/281 (70.11%), Query Frame = 3
Query: 852 GNPIPKIEYTNEEIKTWGNVYRELTKLYPTHACREFLQNLPLLQKYCGYREDNIPQLEDVSQFLKSRSGFTLRPVAGYLSSRDFLAGLAFRVFHCTQYIRHPSDPFYTPEPDCCHELMGHVPLLADSSFAQFSQEIGLASLGASEDEVQRLATCYFFTIEFGLCHQDGELRAYGAGLLSSIGELKHALSNESNIQKFDPKTVMEQECLVTTFQNAYFFTTSFEDAKDKMREFAKTIKKPFDVHYNPYTQMIETLDSTDSLTNVIDNIKGELATITNALRKF 1694
G IP++ YT EEI TWG VYR+L LYPTHAC+E + LL+++CGY ED IPQLEDVS FL R+GF LRP AG LS+RDFLA LAFRVF CTQYIRH S P ++PEPDCCHEL+GHVP+LADS+FAQFSQ G++ + L Y+FT+EFGLC Q+G ++AYGAGLLSS GEL ALS E + F+ + Q T+Q YF + S EDAKDK+R++A+ +++P + ++P T+ + LDST SL +D ++ +++ ++ AL +
Sbjct: 1 GELIPRVHYTQEEIATWGEVYRKLAGLYPTHACKEHVDAFRLLEQHCGYSEDAIPQLEDVSTFLLERTGFQLRPAAGLLSARDFLASLAFRVFQCTQYIRHASSPMHSPEPDCCHELLGHVPMLADSTFAQFSQVSGVSEVSVRTHPCAPLPQLYWFTVEFGLCKQEGHVKAYGAGLLSSFGELMFALSGEPEYRAFEAEAAALQPYQDQTYQPVYFVSDSLEDAKDKLRQYAQGLRRPVALRFDPITRSVHALDSTRSLRTAVDALQEQVSVLSCALSRM 281
BLAST of tph vs. Ensembl Sea Lamprey
Match: ENSPMAT00000001726.1 (pep scaffold:Pmarinus_7.0:GL477470:183489:194417:1 gene:ENSPMAG00000001558.1 transcript:ENSPMAT00000001726.1 gene_biotype:protein_coding transcript_biotype:protein_coding) HSP 1 Score: 95.5153 bits (236), Expect = 5.998e-23 Identity = 75/199 (37.69%), Postives = 98/199 (49.25%), Query Frame = 3
Query: 768 DADHP--GFKDEVYRLRRNQFSEIAYSYKHGNPIPKIEYTNEEIKTWGNVYRELTKLYPTHACREFLQNLPLLQKYCGYREDNIPQLEDVSQFLKSRSGFTLRPVAGYLSSRDFLAGLAFRVFHCTQY-----IRHPSDPFYT-PEPDCCHELMGHVPLLADSSFAQFSQEIGLASLGASEDEVQRLATCYFFTIEFGL 1340
D DHP F E+ RR FSE+A YK P P ++Y+ E W + + P A EF L L Y IPQ VSQ L +GF+L PV G +R L+ LAFRV C+ + + HP+ Y P D C L+G VPLL A+ Q++GLASLG+S +VQ LA ++ EF L
Sbjct: 1 DEDHPYSDFCSELDESRRAYFSELALQYKFREPAPVLQYSARESAAWRSALEAAVRGAPG-AEPEFRAALEEL-TVTAYSASAIPQASHVSQLLHGHTGFSLWPVPGTPPARVLLSALAFRVLPCSLHACPGSVAHPAHRTYGGPLTDVCGLLLGLVPLLTMGPVARAVQDMGLASLGSSNTDVQLLAESFYSVCEFAL 197
BLAST of tph vs. Ensembl Sea Lamprey
Match: ENSPMAT00000006904.1 (pep scaffold:Pmarinus_7.0:GL491535:768:2811:-1 gene:ENSPMAG00000006244.1 transcript:ENSPMAT00000006904.1 gene_biotype:protein_coding transcript_biotype:protein_coding) HSP 1 Score: 54.6842 bits (130), Expect = 7.128e-10 Identity = 27/71 (38.03%), Postives = 46/71 (64.79%), Query Frame = 3
Query: 585 SNINGIRIDTFDLAASEIGEQN----IQL-KNKKPGMTVDNLPWFPKYIKDLDKISNRVIMYGSELDADHP 782
++++G R D E+ Q+ +QL +NK+ D +PWFP+ I+DLD+ +N+++ YG+ELD+DHP
Sbjct: 26 ASVSGERPGALDALLLELRSQSAGSVLQLSRNKRK----DAVPWFPRTIRDLDRFANQILSYGAELDSDHP 92
BLAST of tph vs. Ensembl Nematostella
Match: EDO31745 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7SX22]) HSP 1 Score: 410.609 bits (1054), Expect = 1.299e-139 Identity = 202/405 (49.88%), Postives = 272/405 (67.16%), Query Frame = 3
Query: 330 STRRSTSFIFGVNDNVKGLVRVLEIFEKFRVSVIHIETRKSLKNKSKFEIFIDVDCRKDEIKSLIECLQQKIDDDFHVQEVDMISSNINGIRIDTFDLAASEIGEQNIQLKNKKPGMTVDNLPWFPKYIKDLDKISNRVIMYGSELDADHPGFKDEVYRLRRNQFSEIAYSYKHGNPIPKIEYTNEEIKTWGNVYRELTKLYPTHACREFLQNLPLLQKYCGYREDNIPQLEDVSQFLKSRSGFTLRPVAGYLSSRDFLAGLAFRVFHCTQYIRHPSDPFYTPEPDCCHELMGHVPLLADSSFAQFSQEIGLASLGASEDEVQRLATCYFFTIEFGLCHQDGELRAYGAGLLSSIGELKHALSNESNIQKFDPKTVMEQECLVTTFQNAYFFTTSFEDAKDKMRE 1544
S +++T+ +F +N+ V L R L++FE V++ HIE+R S K++++ F D + ++G ++ F + A + NI + + G ++PWFP+ I DLDK ++RV+ YG+ELD+DHPGF D+VYR RR +F++IA+ +KHG IP++ YT+ EI TW V+ ELTKLYPTHACRE PLL + CGYR NIPQL+DVS FLK +GFTLRPVAG LSSRDFLAGLAFRVFH TQYIRHP+ P YTPEPD HEL+GHVPL AD FAQFSQEIGLASLGA ++ V++LAT Y+FT+EFGLC Q+GE++AYGAGLLSS GEL++ L++E +P+ Q+ +T +Q YF SF A++K+R+
Sbjct: 26 SEKKATTVVFSLNEEVGALARALKLFEDHHVNMTHIESRPSKACKTRYDFFADCE-------------------------------GLHGASLNHF-VDALKKRAVNITVLSDDKG----SVPWFPRKISDLDKFADRVLSYGAELDSDHPGFTDQVYRARRKEFADIAFKHKHGEIIPQVTYTDIEIATWDKVFTELTKLYPTHACREHNFVWPLLVQNCGYRLGNIPQLQDVSMFLKECTGFTLRPVAGLLSSRDFLAGLAFRVFHSTQYIRHPTKPMYTPEPDVVHELIGHVPLFADPDFAQFSQEIGLASLGAPDEWVEKLATLYWFTVEFGLCRQEGEVKAYGAGLLSSFGELQYCLTDEPKKYPLEPEKTSVQKYPITQYQPVYFIADSFLSARNKVRK 394
BLAST of tph vs. Ensembl Medaka
Match: tph1 (tryptophan hydroxylase 1 [Source:NCBI gene;Acc:101175562]) HSP 1 Score: 582.408 bits (1500), Expect = 0.000e+0 Identity = 286/496 (57.66%), Postives = 363/496 (73.19%), Query Frame = 3
Query: 219 RRGR-FSSVSSMIDEE--DFEIIKGELFDLNIVMEENKTISTRRSTSFIFGVNDNVKGLVRVLEIFEKFRVSVIHIETRKSLKNKSKFEIFIDVDCRKDEIKSLIECLQQKIDDDFHVQEVDMISSNINGIRIDTFDLAASEIGEQNIQLKNKKPGMTVDNLPWFPKYIKDLDKISNRVIMYGSELDADHPGFKDEVYRLRRNQFSEIAYSYKHGNPIPKIEYTNEEIKTWGNVYRELTKLYPTHACREFLQNLPLLQKYCGYREDNIPQLEDVSQFLKSRSGFTLRPVAGYLSSRDFLAGLAFRVFHCTQYIRHPSDPFYTPEPDCCHELMGHVPLLADSSFAQFSQEIGLASLGASEDEVQRLATCYFFTIEFGLCHQDGELRAYGAGLLSSIGELKHALSNESNIQKFDPKTVMEQECLVTTFQNAYFFTTSFEDAKDKMREFAKTIKKPFDVHYNPYTQMIETLDSTDSLTNVIDNIKGELATITNALRKFN 1697
RRGR F S++ +E+ + EI K + E+ T R+T IF + + V GLV+ L++F++ V+++HIE+RKS + S+FEIF+D D +++ +I L++ HV VDM + S + E+++ ++PWFPK I DLDK +NRV+MYGSELDADHPGFKD VYR RR F+++A +YKHG+PIP+IE+T EE+KTWG VYREL KLYPTHACRE+L+NLPLL KYC REDNIPQLEDVS+FL+ R+GFT+RPVAGYLS RDFLAGLAFRVFHCTQY+RH SDP YTPEPD CHEL+GHVPLLA+ SFAQFSQEIGLASLGAS+D VQ+LATCYFFT+EFGLC Q+G LRAYGAGLLSSI ELKHALS + I FDPK +QEC++TTFQ+ YF + SFE+AK KMREFAKTIK+PF V YNPYTQ ++ L T S+ +V++ ++ EL + +AL + N
Sbjct: 79 RRGRSFDSMNIGFEEKLLNNEINKSTFNKIEENTEKQNTSEKGRAT-IIFSLKNEVGGLVKALKLFQENHVNLVHIESRKSKRRNSEFEIFVDCDSNHEQLSEIIHLLRK------HVNIVDMNPPD------------NSCLHEEDMY-----------DVPWFPKRISDLDKCANRVLMYGSELDADHPGFKDNVYRKRRKYFADLAMAYKHGDPIPRIEFTEEEVKTWGVVYRELNKLYPTHACREYLKNLPLLSKYCECREDNIPQLEDVSRFLRERTGFTIRPVAGYLSPRDFLAGLAFRVFHCTQYVRHSSDPLYTPEPDTCHELLGHVPLLAEPSFAQFSQEIGLASLGASDDSVQKLATCYFFTVEFGLCKQEGHLRAYGAGLLSSISELKHALSGNARIMPFDPKVTSKQECIITTFQDVYFVSDSFEEAKVKMREFAKTIKRPFTVRYNPYTQSVDVLKDTLSINSVVEELRHELDIVGDALSRLN 544
BLAST of tph vs. Ensembl Medaka
Match: tph1 (tryptophan hydroxylase 1 [Source:NCBI gene;Acc:101175562]) HSP 1 Score: 578.17 bits (1489), Expect = 0.000e+0 Identity = 273/459 (59.48%), Postives = 345/459 (75.16%), Query Frame = 3
Query: 321 KTISTRRSTSFIFGVNDNVKGLVRVLEIFEKFRVSVIHIETRKSLKNKSKFEIFIDVDCRKDEIKSLIECLQQKIDDDFHVQEVDMISSNINGIRIDTFDLAASEIGEQNIQLKNKKPGMTVDNLPWFPKYIKDLDKISNRVIMYGSELDADHPGFKDEVYRLRRNQFSEIAYSYKHGNPIPKIEYTNEEIKTWGNVYRELTKLYPTHACREFLQNLPLLQKYCGYREDNIPQLEDVSQFLKSRSGFTLRPVAGYLSSRDFLAGLAFRVFHCTQYIRHPSDPFYTPEPDCCHELMGHVPLLADSSFAQFSQEIGLASLGASEDEVQRLATCYFFTIEFGLCHQDGELRAYGAGLLSSIGELKHALSNESNIQKFDPKTVMEQECLVTTFQNAYFFTTSFEDAKDKMREFAKTIKKPFDVHYNPYTQMIETLDSTDSLTNVIDNIKGELATITNALRKFN 1697
+ S + + IF + + V GLV+ L++F++ V+++HIE+RKS + S+FEIF+D D +++ +I L++ HV VDM + S + E+++ ++PWFPK I DLDK +NRV+MYGSELDADHPGFKD VYR RR F+++A +YKHG+PIP+IE+T EE+KTWG VYREL KLYPTHACRE+L+NLPLL KYC REDNIPQLEDVS+FL+ R+GFT+RPVAGYLS RDFLAGLAFRVFHCTQY+RH SDP YTPEPD CHEL+GHVPLLA+ SFAQFSQEIGLASLGAS+D VQ+LATCYFFT+EFGLC Q+G LRAYGAGLLSSI ELKHALS + I FDPK +QEC++TTFQ+ YF + SFE+AK KMREFAKTIK+PF V YNPYTQ ++ L T S+ +V++ ++ EL + +AL + N
Sbjct: 4 QNTSEKGRATIIFSLKNEVGGLVKALKLFQENHVNLVHIESRKSKRRNSEFEIFVDCDSNHEQLSEIIHLLRK------HVNIVDMNPPD------------NSCLHEEDMY-----------DVPWFPKRISDLDKCANRVLMYGSELDADHPGFKDNVYRKRRKYFADLAMAYKHGDPIPRIEFTEEEVKTWGVVYRELNKLYPTHACREYLKNLPLLSKYCECREDNIPQLEDVSRFLRERTGFTIRPVAGYLSPRDFLAGLAFRVFHCTQYVRHSSDPLYTPEPDTCHELLGHVPLLAEPSFAQFSQEIGLASLGASDDSVQKLATCYFFTVEFGLCKQEGHLRAYGAGLLSSISELKHALSGNARIMPFDPKVTSKQECIITTFQDVYFVSDSFEEAKVKMREFAKTIKRPFTVRYNPYTQSVDVLKDTLSINSVVEELRHELDIVGDALSRLN 433
BLAST of tph vs. Ensembl Medaka
Match: tph2 (tryptophan hydroxylase 2 [Source:NCBI gene;Acc:101166957]) HSP 1 Score: 571.622 bits (1472), Expect = 0.000e+0 Identity = 270/453 (59.60%), Postives = 343/453 (75.72%), Query Frame = 3
Query: 345 TSFIFGVNDNVKGLVRVLEIFEKFRVSVIHIETRKSLKNKSKFEIFIDVDCRKDEIKSLIECLQQKIDDDFHVQEVDMISSNINGIRIDTFDLAASEIGEQNIQLKNKKPGMTVDNLPWFPKYIKDLDKISNRVIMYGSELDADHPGFKDEVYRLRRNQFSEIAYSYKHGNPIPKIEYTNEEIKTWGNVYRELTKLYPTHACREFLQNLPLLQKYCGYREDNIPQLEDVSQFLKSRSGFTLRPVAGYLSSRDFLAGLAFRVFHCTQYIRHPSDPFYTPEPDCCHELMGHVPLLADSSFAQFSQEIGLASLGASEDEVQRLATCYFFTIEFGLCHQDGELRAYGAGLLSSIGELKHALSNESNIQKFDPKTVMEQECLVTTFQNAYFFTTSFEDAKDKMREFAKTIKKPFDVHYNPYTQMIETLDSTDSLTNVIDNIKGELATITNALRKFNIF 1703
T+ +F + + V LV+ L++F++ RV++ HIE+R S + ++ EIF D C + E + L++ L+ V ++S+N + A + ++++ PWFP I +LD+ S+RV+MYGSELDADHPGFKDEVYR RR F E+A +YK G PIP+IEYT EE++TWG V+RELTKLYPTHAC+E L+NLPLL K+CGYREDNIPQLEDVS FLK RSGFT+RPVAGYLS RDFLAGLAFRVF+CTQYIRH +DP YTPEPD CHEL+GHVPLLAD FAQFSQEIGLASLGAS+++VQ+LATCYFFTIEFGLC QDG LRAYGAGLLSSIGEL+HALS+++ ++ FDPKT QECL+TTFQ YF + SFE+AK+KMREFAKTIK+PF V+YNPYTQ ++ L T S+ NV+ +++ +L T+ +AL K N +
Sbjct: 84 TAVVFSLKNEVGFLVKALQLFQEKRVNLNHIESRVSKRVPNEVEIFADCSCSQKEFEELLQLLRDS---------VSVVSTNTPA------HVWADDADDEDV--------------PWFPMKISELDQCSHRVLMYGSELDADHPGFKDEVYRRRRKYFVEVAMNYKFGQPIPRIEYTPEEVRTWGVVFRELTKLYPTHACKEHLKNLPLLTKHCGYREDNIPQLEDVSMFLKERSGFTVRPVAGYLSPRDFLAGLAFRVFNCTQYIRHGTDPLYTPEPDTCHELLGHVPLLADPKFAQFSQEIGLASLGASDEDVQKLATCYFFTIEFGLCKQDGHLRAYGAGLLSSIGELRHALSDKACVRMFDPKTTCNQECLITTFQEVYFVSESFEEAKEKMREFAKTIKRPFSVYYNPYTQSVDLLKDTRSIENVVQDLRSDLTTVCDALGKMNTY 507
BLAST of tph vs. Ensembl Medaka
Match: tph1b (tryptophan 5-hydroxylase 1 [Source:NCBI gene;Acc:101170994]) HSP 1 Score: 563.148 bits (1450), Expect = 0.000e+0 Identity = 260/458 (56.77%), Postives = 339/458 (74.02%), Query Frame = 3
Query: 324 TISTRRSTSFIFGVNDNVKGLVRVLEIFEKFRVSVIHIETRKSLKNKSKFEIFIDVDCRKDEIKSLIECLQQKIDDDFHVQEVDMISSNINGIRIDTFDLAASEIGEQNIQLKNKKPGMTVDNLPWFPKYIKDLDKISNRVIMYGSELDADHPGFKDEVYRLRRNQFSEIAYSYKHGNPIPKIEYTNEEIKTWGNVYRELTKLYPTHACREFLQNLPLLQKYCGYREDNIPQLEDVSQFLKSRSGFTLRPVAGYLSSRDFLAGLAFRVFHCTQYIRHPSDPFYTPEPDCCHELMGHVPLLADSSFAQFSQEIGLASLGASEDEVQRLATCYFFTIEFGLCHQDGELRAYGAGLLSSIGELKHALSNESNIQKFDPKTVMEQECLVTTFQNAYFFTTSFEDAKDKMREFAKTIKKPFDVHYNPYTQMIETLDSTDSLTNVIDNIKGELATITNALRKFN 1697
S +R+ + IF + + V GL++ L++F++ V ++HIE+RKS + S FE+F+D D +++K L + ++S++ + I F S + E + + D +PWFPK I DLD+ +NRV+MYGS+LDADHPGFKD VYR RR F+++A ++KHGNPIPKI YT EE+ TWG V+REL KLYP+HAC+E+L+NLPLL + C Y EDNIPQLEDVS+FLK +SGFT+RPVAGYLS RDFLAGLAFRVFHCTQY+RH S+P YTPEPD CHEL+GHVPLLA+ SFAQFSQEIGLASLGAS+D V++LATCYFFT+EFGLC QDG+LRAYGAGLLSS ELKH+LS ++NI FDP QEC++TTFQ AYF SFE+AK+KMREFAKT+ +PF VHYNPYTQ ++ L +T ++ +++ +I+ EL + AL +
Sbjct: 42 ACSRKRTATIIFTLKNEVGGLIKALKLFQEKHVHLVHIESRKSRRRDSDFEVFVDCDSEHEQMKELTQ----------------LLSTHAQIVEITPFG-GCSPLAEDD-----RADAPEADGVPWFPKKISDLDQCANRVLMYGSDLDADHPGFKDSVYRKRRQYFADVAMTFKHGNPIPKIHYTAEEVCTWGVVFRELHKLYPSHACKEYLKNLPLLTRDCCYSEDNIPQLEDVSKFLKGQSGFTIRPVAGYLSPRDFLAGLAFRVFHCTQYVRHSSEPLYTPEPDTCHELLGHVPLLAEPSFAQFSQEIGLASLGASDDAVKKLATCYFFTVEFGLCKQDGKLRAYGAGLLSSASELKHSLSGKANILPFDPILTCNQECMITTFQEAYFVAESFEEAKNKMREFAKTLHRPFTVHYNPYTQSVDVLTNTHNINSMVKDIRHELDIVEEALNQLG 477
BLAST of tph vs. Ensembl Medaka
Match: tph1b (tryptophan 5-hydroxylase 1 [Source:NCBI gene;Acc:101170994]) HSP 1 Score: 562.377 bits (1448), Expect = 0.000e+0 Identity = 260/455 (57.14%), Postives = 339/455 (74.51%), Query Frame = 3
Query: 330 STRRSTSFIFGVNDNVKGLVRVLEIFEKFRVSVIHIETRKSLKNKSKFEIFIDVDCRKDEIKSLIECLQQKIDDDFHVQEVDMISSNINGIRIDTFDLAASEIGEQNIQLKNKKPGMTVDNLPWFPKYIKDLDKISNRVIMYGSELDADHPGFKDEVYRLRRNQFSEIAYSYKHGNPIPKIEYTNEEIKTWGNVYRELTKLYPTHACREFLQNLPLLQKYCGYREDNIPQLEDVSQFLKSRSGFTLRPVAGYLSSRDFLAGLAFRVFHCTQYIRHPSDPFYTPEPDCCHELMGHVPLLADSSFAQFSQEIGLASLGASEDEVQRLATCYFFTIEFGLCHQDGELRAYGAGLLSSIGELKHALSNESNIQKFDPKTVMEQECLVTTFQNAYFFTTSFEDAKDKMREFAKTIKKPFDVHYNPYTQMIETLDSTDSLTNVIDNIKGELATITNALRKF 1694
S +R+ + IF + + V GL++ L++F++ V ++HIE+RKS + S FE+F+D D +++K L + ++S++ + I F S + E + + D +PWFPK I DLD+ +NRV+MYGS+LDADHPGFKD VYR RR F+++A ++KHGNPIPKI YT EE+ TWG V+REL KLYP+HAC+E+L+NLPLL + C Y EDNIPQLEDVS+FLK +SGFT+RPVAGYLS RDFLAGLAFRVFHCTQY+RH S+P YTPEPD CHEL+GHVPLLA+ SFAQFSQEIGLASLGAS+D V++LATCYFFT+EFGLC QDG+LRAYGAGLLSS ELKH+LS ++NI FDP QEC++TTFQ AYF SFE+AK+KMREFAKT+ +PF VHYNPYTQ ++ L +T ++ +++ +I+ EL + AL +
Sbjct: 8 SQKRTATIIFTLKNEVGGLIKALKLFQEKHVHLVHIESRKSRRRDSDFEVFVDCDSEHEQMKELTQ----------------LLSTHAQIVEITPFG-GCSPLAEDD-----RADAPEADGVPWFPKKISDLDQCANRVLMYGSDLDADHPGFKDSVYRKRRQYFADVAMTFKHGNPIPKIHYTAEEVCTWGVVFRELHKLYPSHACKEYLKNLPLLTRDCCYSEDNIPQLEDVSKFLKGQSGFTIRPVAGYLSPRDFLAGLAFRVFHCTQYVRHSSEPLYTPEPDTCHELLGHVPLLAEPSFAQFSQEIGLASLGASDDAVKKLATCYFFTVEFGLCKQDGKLRAYGAGLLSSASELKHSLSGKANILPFDPILTCNQECMITTFQEAYFVAESFEEAKNKMREFAKTLHRPFTVHYNPYTQSVDVLTNTHNINSMVKDIRHELDIVEEALNQL 440
BLAST of tph vs. Planmine SMEST
Match: SMESG000000522.1 (SMESG000000522.1) HSP 1 Score: 1133.63 bits (2931), Expect = 0.000e+0 Identity = 544/545 (99.82%), Postives = 545/545 (100.00%), Query Frame = 3
Query: 108 MSDREKEKVSNKRNSIISLTKAKSVGESSIQINTAKTRRGRFSSVSSMIDEEDFEIIKGELFDLNIVMEENKTISTRRSTSFIFGVNDNVKGLVRVLEIFEKFRVSVIHIETRKSLKNKSKFEIFIDVDCRKDEIKSLIECLQQKIDDDFHVQEVDMISSNINGIRIDTFDLAASEIGEQNIQLKNKKPGMTVDNLPWFPKYIKDLDKISNRVIMYGSELDADHPGFKDEVYRLRRNQFSEIAYSYKHGNPIPKIEYTNEEIKTWGNVYRELTKLYPTHACREFLQNLPLLQKYCGYREDNIPQLEDVSQFLKSRSGFTLRPVAGYLSSRDFLAGLAFRVFHCTQYIRHPSDPFYTPEPDCCHELMGHVPLLADSSFAQFSQEIGLASLGASEDEVQRLATCYFFTIEFGLCHQDGELRAYGAGLLSSIGELKHALSNESNIQKFDPKTVMEQECLVTTFQNAYFFTTSFEDAKDKMREFAKTIKKPFDVHYNPYTQMIETLDSTDSLTNVIDNIKGELATITNALRKFNIFWHGTQMAQINNSN 1742
MSDREKEKVSNKRNSIISLTKAKSVGESSIQINTAKTRRGRFSSVSSMIDEEDFEIIKGELFDLNIVMEENKTISTRRSTSFIFGVNDNVKGLVRVLEIFEKFRVSVIHIETRKSLKNKSKFEIFIDVDCRKDEIKSLIECLQQKIDDDFHVQEVDMISSNINGIRIDTFDLAASEIGEQNIQLKNKKPGMTVDNLPWFPKYIKDLDKISNRVIMYGSELDADHPGFKDEVYRLRRNQFSEIAYSYKHGNPIPKIEYTNEEIKTWGNVYRELTKLYPTHACREFLQNLPLLQKYCGYREDNIPQLEDVSQFLKSRSGFTLRPVAGYLSSRDFLAGLAFRVFHCTQYIRHPSDPFYTPEPDCCHELMGHVPLLADSSFAQFSQEIGLASLGASEDEVQRLATCYFFTIEFGLCHQDGELRAYGAGLLSSIGELKHALSNESNIQKFDPKTVMEQECLVTTFQNAYFFTTSFEDAKDKMREFAKTIKKPFDVHYNPYTQMIETLDSTDSLTNVIDNIKGELATITNALRKFNIFWHGTQMA+INNSN
Sbjct: 1 MSDREKEKVSNKRNSIISLTKAKSVGESSIQINTAKTRRGRFSSVSSMIDEEDFEIIKGELFDLNIVMEENKTISTRRSTSFIFGVNDNVKGLVRVLEIFEKFRVSVIHIETRKSLKNKSKFEIFIDVDCRKDEIKSLIECLQQKIDDDFHVQEVDMISSNINGIRIDTFDLAASEIGEQNIQLKNKKPGMTVDNLPWFPKYIKDLDKISNRVIMYGSELDADHPGFKDEVYRLRRNQFSEIAYSYKHGNPIPKIEYTNEEIKTWGNVYRELTKLYPTHACREFLQNLPLLQKYCGYREDNIPQLEDVSQFLKSRSGFTLRPVAGYLSSRDFLAGLAFRVFHCTQYIRHPSDPFYTPEPDCCHELMGHVPLLADSSFAQFSQEIGLASLGASEDEVQRLATCYFFTIEFGLCHQDGELRAYGAGLLSSIGELKHALSNESNIQKFDPKTVMEQECLVTTFQNAYFFTTSFEDAKDKMREFAKTIKKPFDVHYNPYTQMIETLDSTDSLTNVIDNIKGELATITNALRKFNIFWHGTQMAEINNSN 545
BLAST of tph vs. Planmine SMEST
Match: SMESG000000522.1 (SMESG000000522.1) HSP 1 Score: 1001.89 bits (2589), Expect = 0.000e+0 Identity = 477/478 (99.79%), Postives = 478/478 (100.00%), Query Frame = 3
Query: 309 MEENKTISTRRSTSFIFGVNDNVKGLVRVLEIFEKFRVSVIHIETRKSLKNKSKFEIFIDVDCRKDEIKSLIECLQQKIDDDFHVQEVDMISSNINGIRIDTFDLAASEIGEQNIQLKNKKPGMTVDNLPWFPKYIKDLDKISNRVIMYGSELDADHPGFKDEVYRLRRNQFSEIAYSYKHGNPIPKIEYTNEEIKTWGNVYRELTKLYPTHACREFLQNLPLLQKYCGYREDNIPQLEDVSQFLKSRSGFTLRPVAGYLSSRDFLAGLAFRVFHCTQYIRHPSDPFYTPEPDCCHELMGHVPLLADSSFAQFSQEIGLASLGASEDEVQRLATCYFFTIEFGLCHQDGELRAYGAGLLSSIGELKHALSNESNIQKFDPKTVMEQECLVTTFQNAYFFTTSFEDAKDKMREFAKTIKKPFDVHYNPYTQMIETLDSTDSLTNVIDNIKGELATITNALRKFNIFWHGTQMAQINNSN 1742
MEENKTISTRRSTSFIFGVNDNVKGLVRVLEIFEKFRVSVIHIETRKSLKNKSKFEIFIDVDCRKDEIKSLIECLQQKIDDDFHVQEVDMISSNINGIRIDTFDLAASEIGEQNIQLKNKKPGMTVDNLPWFPKYIKDLDKISNRVIMYGSELDADHPGFKDEVYRLRRNQFSEIAYSYKHGNPIPKIEYTNEEIKTWGNVYRELTKLYPTHACREFLQNLPLLQKYCGYREDNIPQLEDVSQFLKSRSGFTLRPVAGYLSSRDFLAGLAFRVFHCTQYIRHPSDPFYTPEPDCCHELMGHVPLLADSSFAQFSQEIGLASLGASEDEVQRLATCYFFTIEFGLCHQDGELRAYGAGLLSSIGELKHALSNESNIQKFDPKTVMEQECLVTTFQNAYFFTTSFEDAKDKMREFAKTIKKPFDVHYNPYTQMIETLDSTDSLTNVIDNIKGELATITNALRKFNIFWHGTQMA+INNSN
Sbjct: 1 MEENKTISTRRSTSFIFGVNDNVKGLVRVLEIFEKFRVSVIHIETRKSLKNKSKFEIFIDVDCRKDEIKSLIECLQQKIDDDFHVQEVDMISSNINGIRIDTFDLAASEIGEQNIQLKNKKPGMTVDNLPWFPKYIKDLDKISNRVIMYGSELDADHPGFKDEVYRLRRNQFSEIAYSYKHGNPIPKIEYTNEEIKTWGNVYRELTKLYPTHACREFLQNLPLLQKYCGYREDNIPQLEDVSQFLKSRSGFTLRPVAGYLSSRDFLAGLAFRVFHCTQYIRHPSDPFYTPEPDCCHELMGHVPLLADSSFAQFSQEIGLASLGASEDEVQRLATCYFFTIEFGLCHQDGELRAYGAGLLSSIGELKHALSNESNIQKFDPKTVMEQECLVTTFQNAYFFTTSFEDAKDKMREFAKTIKKPFDVHYNPYTQMIETLDSTDSLTNVIDNIKGELATITNALRKFNIFWHGTQMAEINNSN 478
BLAST of tph vs. Planmine SMEST
Match: SMESG000077798.1 (SMESG000077798.1) HSP 1 Score: 454.136 bits (1167), Expect = 1.163e-155 Identity = 220/451 (48.78%), Postives = 293/451 (64.97%), Query Frame = 3
Query: 342 STSFIFGVNDNVKGLVRVLEIFEKFRVSVIHIETRKSLKNKSKFEIFIDVDCRKDEIKSLIECLQQKIDDDFHVQEVDMISSNINGIRIDTFDLAASEIGEQNIQLKNKKPGMTVDNLPWFPKYIKDLDKISNRVIMYGSELDADHPGFKDEVYRLRRNQFSEIAYSYKHGNPIPKIEYTNEEIKTWGNVYRELTKLYPTHACREFLQNLPLLQKYCGYREDNIPQLEDVSQFLKSRSGFTLRPVAGYLSSRDFLAGLAFRVFHCTQYIRHPSDPFYTPEPDCCHELMGHVPLLADSSFAQFSQEIGLASLGASEDEVQRLATCYFFTIEFGLCHQDGELRAYGAGLLSSIGELKHALSNESNIQKFDPKTVMEQECLVTTFQNAYFFTTSFEDAKDKMREFAKTIKKPFDVHYNPYTQMIETLDSTDSLTNVIDNIKGELATITNALRKF 1694
+T+ + + + L +LEIF+K V+++HIE+R S K +++ I+ D R + IE LQ L + Q+ LK ++PWFP+ IKDLD+ +N+++ YGSELDADHPGF D VYR RR QF++IA+ YKHG PI ++EYT EEI TW V+ +LT LYPTHAC+EF PLLQ+ CGY DNIPQL+DVS FLK +GFTLRPVAG LSSRDFLAGL+FRVFH TQYIRH P YTPEPD CHEL+GHVPL + FAQFSQEIGLASLGAS++ +++LATCY+FT+EFGLC + +++AYGAGLLSS GEL++ L++E FDP+ Q+ + +Q YF SF DAK ++R F+K + +PF V Y+PYTQ +E LD + ++ ++K + + AL K
Sbjct: 23 NTTILITASSKIGSLASILEIFKKNHVNLLHIESRPSKNLKEQYDFLINADNRTGGLMMAIENLQ-------------------------GLSLEVQVLSRQHDNLKG--------DVPWFPRKIKDLDRFANQILSYGSELDADHPGFTDPVYRERRKQFADIAFFYKHGQPIQRVEYTKEEINTWRTVFDKLTTLYPTHACKEFNYVFPLLQENCGYNRDNIPQLQDVSDFLKDCTGFTLRPVAGLLSSRDFLAGLSFRVFHSTQYIRHSKVPLYTPEPDVCHELLGHVPLFCNPEFAQFSQEIGLASLGASDEYIEKLATCYWFTVEFGLCKEHDKIKAYGAGLLSSFGELQYCLTDEPKKLSFDPQVTGLQKYPIVEYQPIYFVAESFADAKIRLRNFSKMVDRPFAVKYDPYTQTVEVLDKNSQIKQLMISLKDDFNVLEEALNKL 440
BLAST of tph vs. Planmine SMEST
Match: SMESG000034472.1 (SMESG000034472.1) HSP 1 Score: 364.77 bits (935), Expect = 4.992e-120 Identity = 172/340 (50.59%), Postives = 238/340 (70.00%), Query Frame = 3
Query: 684 VDNLPWFPKYIKDLDKISNRVIMYGSELDADHPGFKDEVYRLRRNQFSEIAYSYKHGNPIPKIEYTNEEIKTWGNVYRELTKLYPTHACREFLQNLPLLQKYCGYREDNIPQLEDVSQFLKSRSGFTLRPVAGYLSSRDFLAGLAFRVFHCTQYIRHPSDPFYTPEPDCCHELMGHVPLLADSSFAQFSQEIGLASLGASEDEVQRLATCYFFTIEFGLCHQDGELRAYGAGLLSSIGELKHALSNESNIQKFDPKTVMEQECLVTTFQNAYFFTTSFEDAKDKMREFAKTIKKPFDVHYNPYTQMIETLDSTDSLTNVIDNIKGELATITNALRKFNIF 1703
VD++ W PK+I DLD ++ V+ + E+ +DHPGF D+ Y+ RR + +EIA+++KHG IP++EY E TW Y LT LY +AC+E L + L++ C Y DNIPQLEDVS +LK +SGF LRPVAG LS+RDFLA L FRVF CTQY RH S P +TPEPDC HEL+GHVP+L+D FA+FSQEIGL SLGAS+++++RLAT Y+FT+EFGLC++D +++A+GAGLLSS GEL+HA+S+ + F+P+T +Q Y+ S D K+KMR+FAK+I + + Y+PYT+ IE L++ S+ ++ IK EL + N+L F
Sbjct: 154 VDDI-WIPKHISDLDNCNHLVLKFQPEMASDHPGFHDKEYQKRRMEIAEIAFNFKHGEKIPRVEYLESEKNTWKEAYIALTSLYKDYACKEQLIGIKRLEEECEYGPDNIPQLEDVSNYLKKKSGFQLRPVAGLLSARDFLASLGFRVFQCTQYTRHHSKPLHTPEPDCIHELLGHVPVLSDMEFAEFSQEIGLCSLGASDEDIERLATLYWFTVEFGLCYEDKKMKAFGAGLLSSSGELQHAISDVPEHRIFEPQTASITPYRDEEYQPVYYVIDSVTDMKEKMRQFAKSIHRQNPIRYDPYTETIEVLNNKKSVCHLGRVIKRELDNMENSLSSMLTF 492 The following BLAST results are available for this feature:
BLAST of tph vs. Ensembl Human
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Human e!99) Total hits: 5
BLAST of tph vs. Ensembl Celegans
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99) Total hits: 5
BLAST of tph vs. Ensembl Fly
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99) Total hits: 5
BLAST of tph vs. Ensembl Zebrafish
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99) Total hits: 5
BLAST of tph vs. Ensembl Xenopus
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99) Total hits: 5
BLAST of tph vs. Ensembl Mouse
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99) Total hits: 5
BLAST of tph vs. UniProt/SwissProt
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt) Total hits: 5
BLAST of tph vs. TrEMBL
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL) Total hits: 5
BLAST of tph vs. Ensembl Cavefish
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99) Total hits: 5
BLAST of tph vs. Ensembl Sea Lamprey
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99) Total hits: 4
BLAST of tph vs. Ensembl Yeast
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46) Total hits: 0
BLAST of tph vs. Ensembl Nematostella
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46) Total hits: 1
BLAST of tph vs. Ensembl Medaka
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99) Total hits: 5
BLAST of tph vs. Planmine SMEST
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST) Total hits: 4
Analyses
This transcript is derived from or has results from the following analyses Cross References
External references for this transcript
Sequences
The following sequences are available for this feature:
transcript sequence >SMED30012020 ID=SMED30012020|Name=tph|organism=Schmidtea mediterranea sexual|type=transcript|length=1774bpback to top protein sequence of SMED30012020-orf-1 >SMED30012020-orf-1 ID=SMED30012020-orf-1|Name=SMED30012020-orf-1|organism=Schmidtea mediterranea sexual|type=polypeptide|length=546bp MSDREKEKVSNKRNSIISLTKAKSVGESSIQINTAKTRRGRFSSVSSMIDback to top Aliases
The feature 'tph' has the following synonyms
Annotated Terms
The following terms have been associated with this transcript:
InterPro
Analysis Name: Schmidtea mediteranean smed_20140614 Interproscan
Date Performed: 2020-05-01
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