tyrosine hydroxylase

Overview
Nametyrosine hydroxylase (AEE89449.1)
Smed IDSMED30012000
Length (bp)841
Neoblast Clusters

Zeng et. al., 2018



▻ Overview

▻ Neoblast Population

▻ Sub-lethal Irradiated Surviving X1 and X2 Cell Population

 

 

Overview

 

Single cell RNA-seq of pluripotent neoblasts and its early progenies


We isolated X1 neoblasts cells enriched in high piwi-1 expression (Neoblast Population), and profiled ∼7,614 individual cells via scRNA-seq. Unsupervised analyses uncovered 12 distinct classes from 7,088 high-quality cells. We designated these classes Nb1 to Nb12 and ordered them based on high (Nb1) to low (Nb12) piwi-1 expression levels. We further defined groups of genes that best classified the cells parsed into 12 distinct cell clusters to generate a scaled expression heat map of discriminative gene sets for each cluster. Expression of each cluster’s gene signatures was validated using multiplex fluorescence in situ hybridization (FISH) co-stained with piwi-1 and largely confirmed the cell clusters revealed by scRNA-seq.

We also tested sub-lethal irradiation exposure. To profile rare pluripotent stem cells (PSCs) and avoid interference from immediate progenitor cells, we determined a time point after sub-lethal irradiation (7 DPI) with minimal piwi-1+ cells, followed by isolation and single-cell RNA-seq of 1,200 individual cells derived from X1 (Piwi-1 high) and X2 (Piwi-1 low) cell populations (Sub-lethal Irradiated Surviving X1 and X2 Cell Population)



Explore this single cell expression dataset with our NB Cluster Shiny App



 

Neoblast Population

 

t-SNE plot shows two-dimensional representation of global gene expression relationships among all neoblasts (n = 7,088 after filter). Cluster identity was assigned based on the top 10 marker genes of each cluster (Table S2), followed by inspection of RNA in situ hybridization patterns. Neoblast groups, Nb.


Expression of tyrosine hydroxylase (SMED30012000) t-SNE clustered cells

Violin plots show distribution of expression levels for tyrosine hydroxylase (SMED30012000) in cells (dots) of each of the 12 neoblast clusters.

 

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Sub-lethal Irradiated Surviving X1 and X2 Cell Population

 

t-SNE plot of surviving X1 and X2 cells (n = 1,039 after QC filter) after sub-lethal irradiation. Colors indicate unbiased cell classification via graph-based clustering. SL, sub-lethal irradiated cell groups.

Expression of tyrosine hydroxylase (SMED30012000) in the t-SNE clustered sub-lethally irradiated X1 and X2 cells.

Violin plots show distribution of expression levels for tyrosine hydroxylase (SMED30012000) in cells (dots) of each of the 10 clusters of sub-leathally irradiated X1 and X2 cells.

 

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Embryonic Expression

Davies et. al., 2017

Hover the mouse over a column in the graph to view average RPKM values per sample.
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Embryonic Stages: Y: yolk. S2-S8: Stages 2-8. C4: asexual adult. SX: virgin, sexually mature adult.
For further information about sample preparation and analysis for the single animal RNA-Seq experiment, please refer to the Materials and Methods

 

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Anatomical Expression

PAGE et. al., 2020



SMED30012000

has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGE



PAGE Curations: 13

  
Expressed InReference TranscriptGene ModelsPublished TranscriptTranscriptomePublicationSpecimenLifecycleEvidence
head regionSMED30012000SMESG000034472.1 SmedASXL_014407SmedAsxl_ww_GCZZ01PMID:27034770
Currie et al., 2016		whole organism asexual adult RNA-sequencing evidence
nervous systemSMED30012000SMESG000034472.1 dd_Smed_v4_16581_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018		FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
cephalic gangliaSMED30012000SMESG000034472.1 dd_Smed_v4_16581_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018		FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
neuronSMED30012000SMESG000034472.1 dd_Smed_v4_16581_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018		whole organism asexual adult colorimetric in situ hybridization evidence
neuronSMED30012000SMESG000034472.1 dd_Smed_v4_16581_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018		whole organism asexual adult fluorescence in situ hybridization evidence
cilated neuronSMED30012000SMESG000034472.1 dd_Smed_v4_16581_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018		FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
head regionSMED30012000SMESG000034472.1 dd_Smed_v6_16581_0_1dd_Smed_v6PMID:28171748
Stückemann et al., 2017		whole organism asexual adult RNA-sequencing evidence
dopaminergic neuronSMED30012000SMESG000034472.1 HM777014.1smed_ncbi_20200123PMID:30194301
Mihaylova et al., 2018		whole organism asexual adult colorimetric in situ hybridization evidence
dopaminergic neuronSMED30012000SMESG000034472.1 SMED30012000smed_20140614PMID:30194301
Mihaylova et al., 2018		whole organism asexual adult colorimetric in situ hybridization evidence
dopaminergic neuronSMED30012000SMESG000034472.1 HM777014.1smed_ncbi_20200123PMID:24131630
März et al., 2013		whole organism asexual adult colorimetric in situ hybridization evidence
head regionSMED30012000SMESG000034472.1 OX_Smed_1.0.11668ox_Smed_v2PMID:24238224
Kao et al., 2013		whole organism asexual adult RNA-sequencing evidence
cephalic gangliaSMED30012000SMESG000034472.1 thsmed_ncbi_20200123PMID:28976975
Su et al., 2017		whole organism asexual adult fluorescence in situ hybridization evidence
dopaminergic neuronSMED30012000SMESG000034472.1 thsmed_ncbi_20200123PMID:29357350
de Sousa et al., 2018		whole organism asexual adult colorimetric in situ hybridization evidence
Note: Hover over icons to view figure legend
Homology
[Close]
BLAST of tyrosine hydroxylase vs. Ensembl Human
Match: TH (tyrosine hydroxylase [Source:HGNC Symbol;Acc:HGNC:11782])

HSP 1 Score: 47.3654 bits (111), Expect = 2.011e-9
Identity = 19/35 (54.29%), Postives = 27/35 (77.14%), Query Frame = 1 
Query:  736 EFQPEMASDHPGFHDKEYQKRRMEIAEIAFNFKHG 840
            +F P++  DHPGF D+ Y++RR  IAEIAF ++HG
Sbjct:  213 KFDPDLDLDHPGFSDQVYRQRRKLIAEIAFQYRHG 247

HSP 2 Score: 33.8834 bits (76), Expect = 2.011e-9
Identity = 10/20 (50.00%), Postives = 15/20 (75.00%), Query Frame = 2 
Query:  686 WIPKHISDLDNCNHLVLNFN 745
            W P+ +S+LD C+HLV  F+
Sbjct:  196 WFPRKVSELDKCHHLVTKFD 215
[Close]
BLAST of tyrosine hydroxylase vs. Ensembl Human
Match: TH (tyrosine hydroxylase [Source:HGNC Symbol;Acc:HGNC:11782])

HSP 1 Score: 47.3654 bits (111), Expect = 2.065e-9
Identity = 19/35 (54.29%), Postives = 27/35 (77.14%), Query Frame = 1 
Query:  736 EFQPEMASDHPGFHDKEYQKRRMEIAEIAFNFKHG 840
            +F P++  DHPGF D+ Y++RR  IAEIAF ++HG
Sbjct:  182 KFDPDLDLDHPGFSDQVYRQRRKLIAEIAFQYRHG 216

HSP 2 Score: 33.8834 bits (76), Expect = 2.065e-9
Identity = 10/20 (50.00%), Postives = 15/20 (75.00%), Query Frame = 2 
Query:  686 WIPKHISDLDNCNHLVLNFN 745
            W P+ +S+LD C+HLV  F+
Sbjct:  165 WFPRKVSELDKCHHLVTKFD 184
[Close]
BLAST of tyrosine hydroxylase vs. Ensembl Human
Match: TH (tyrosine hydroxylase [Source:HGNC Symbol;Acc:HGNC:11782])

HSP 1 Score: 47.3654 bits (111), Expect = 2.081e-9
Identity = 19/35 (54.29%), Postives = 27/35 (77.14%), Query Frame = 1 
Query:  736 EFQPEMASDHPGFHDKEYQKRRMEIAEIAFNFKHG 840
            +F P++  DHPGF D+ Y++RR  IAEIAF ++HG
Sbjct:  182 KFDPDLDLDHPGFSDQVYRQRRKLIAEIAFQYRHG 216

HSP 2 Score: 33.8834 bits (76), Expect = 2.081e-9
Identity = 10/20 (50.00%), Postives = 15/20 (75.00%), Query Frame = 2 
Query:  686 WIPKHISDLDNCNHLVLNFN 745
            W P+ +S+LD C+HLV  F+
Sbjct:  165 WFPRKVSELDKCHHLVTKFD 184
[Close]
BLAST of tyrosine hydroxylase vs. Ensembl Human
Match: TH (tyrosine hydroxylase [Source:HGNC Symbol;Acc:HGNC:11782])

HSP 1 Score: 47.3654 bits (111), Expect = 2.164e-9
Identity = 19/35 (54.29%), Postives = 27/35 (77.14%), Query Frame = 1 
Query:  736 EFQPEMASDHPGFHDKEYQKRRMEIAEIAFNFKHG 840
            +F P++  DHPGF D+ Y++RR  IAEIAF ++HG
Sbjct:  209 KFDPDLDLDHPGFSDQVYRQRRKLIAEIAFQYRHG 243

HSP 2 Score: 33.8834 bits (76), Expect = 2.164e-9
Identity = 10/20 (50.00%), Postives = 15/20 (75.00%), Query Frame = 2 
Query:  686 WIPKHISDLDNCNHLVLNFN 745
            W P+ +S+LD C+HLV  F+
Sbjct:  192 WFPRKVSELDKCHHLVTKFD 211
[Close]
BLAST of tyrosine hydroxylase vs. Ensembl Human
Match: TPH1 (tryptophan hydroxylase 1 [Source:HGNC Symbol;Acc:HGNC:12008])

HSP 1 Score: 42.3578 bits (98), Expect = 2.696e-7
Identity = 17/31 (54.84%), Postives = 23/31 (74.19%), Query Frame = 1 
Query:  748 EMASDHPGFHDKEYQKRRMEIAEIAFNFKHG 840
            E+ +DHPGF D  Y+KRR   A++A N+KHG
Sbjct:  128 ELDADHPGFKDNVYRKRRKYFADLAMNYKHG 158

HSP 2 Score: 31.5722 bits (70), Expect = 2.696e-7
Identity = 25/99 (25.25%), Postives = 50/99 (50.51%), Query Frame = 2 
Query:  467 NIELIHIESRQVNSKN-----YSDASMNGLIYNSLEILFVFNCTRRSYKEIIAKLIDEDKNYQKLTEFKIKDEIVDDI-WIPKHISDLDNCNHLVLNFN 745
            ++ L+HIESR+   +N     + D  +N    N +  L       +S+  +++  + ++        F +K++ ++ + W PK ISDLD+C + VL + 
Sbjct:   42 HVNLLHIESRKSKRRNSEFEIFVDCDINREQLNDIFHLL------KSHTNVLSVNLPDN--------FTLKEDGMETVPWFPKKISDLDHCANRVLMYG 126
[Close]
BLAST of tyrosine hydroxylase vs. Ensembl Celegans
Match: tph-1 (TryPtophan Hydroxylase [Source:UniProtKB/TrEMBL;Acc:Q2V4U7])

HSP 1 Score: 46.595 bits (109), Expect = 3.900e-8
Identity = 18/30 (60.00%), Postives = 24/30 (80.00%), Query Frame = 1 
Query:  751 MASDHPGFHDKEYQKRRMEIAEIAFNFKHG 840
            + +DHPGF D EY++RRM  AE+A N+KHG
Sbjct:  209 LDADHPGFKDTEYRQRRMMFAELALNYKHG 238

HSP 2 Score: 28.8758 bits (63), Expect = 3.900e-8
Identity = 26/107 (24.30%), Postives = 47/107 (43.93%), Query Frame = 2 
Query:  443 VISNLKNANIELIHIESRQVNSKNYSDASMNGLI------YNSLEILFVFNCTRRSYKEIIAKLIDEDKNYQKLTEFKIKDEIVDDIWIPKHISDLDNCNHLVLNFN 745
            +I+NL + +  + H+E+R  +S++ S  +M+ L+      Y   E + +         E+ +  I      ++ TE    D      W PK I DLD C   V+ + 
Sbjct:  104 MIANLPD-HTRIKHLETR--DSQDGSSKTMDVLLEIELFHYGKQEAMDLMRLNGLDVHEV-SSTIRPTAIKEQYTEPGSDDATTGSEWFPKSIYDLDICAKRVIMYG 206
[Close]
BLAST of tyrosine hydroxylase vs. Ensembl Celegans
Match: tph-1 (TryPtophan Hydroxylase [Source:UniProtKB/TrEMBL;Acc:Q2V4U7])

HSP 1 Score: 46.2098 bits (108), Expect = 5.523e-8
Identity = 18/30 (60.00%), Postives = 24/30 (80.00%), Query Frame = 1 
Query:  751 MASDHPGFHDKEYQKRRMEIAEIAFNFKHG 840
            + +DHPGF D EY++RRM  AE+A N+KHG
Sbjct:  106 LDADHPGFKDTEYRQRRMMFAELALNYKHG 135

HSP 2 Score: 28.4906 bits (62), Expect = 5.523e-8
Identity = 26/107 (24.30%), Postives = 47/107 (43.93%), Query Frame = 2 
Query:  443 VISNLKNANIELIHIESRQVNSKNYSDASMNGLI------YNSLEILFVFNCTRRSYKEIIAKLIDEDKNYQKLTEFKIKDEIVDDIWIPKHISDLDNCNHLVLNFN 745
            +I+NL + +  + H+E+R  +S++ S  +M+ L+      Y   E + +         E+ +  I      ++ TE    D      W PK I DLD C   V+ + 
Sbjct:    1 MIANLPD-HTRIKHLETR--DSQDGSSKTMDVLLEIELFHYGKQEAMDLMRLNGLDVHEV-SSTIRPTAIKEQYTEPGSDDATTGSEWFPKSIYDLDICAKRVIMYG 103
[Close]
BLAST of tyrosine hydroxylase vs. Ensembl Fly
Match: ple (gene:FBgn0005626 transcript:FBtr0076956)

HSP 1 Score: 47.7506 bits (112), Expect = 3.161e-11
Identity = 19/35 (54.29%), Postives = 29/35 (82.86%), Query Frame = 1 
Query:  736 EFQPEMASDHPGFHDKEYQKRRMEIAEIAFNFKHG 840
            +++P++  +HPGF DK Y++RR EIAEIAF +K+G
Sbjct:  190 KYEPDLDMNHPGFADKVYRQRRKEIAEIAFAYKYG 224

HSP 2 Score: 38.891 bits (89), Expect = 3.161e-11
Identity = 43/189 (22.75%), Postives = 82/189 (43.39%), Query Frame = 2 
Query:  224 NSRRLQFQKTFSYEHQSEFHRRSIIEDAKFDAALNSEFSNHF------KNNEFPDEEE--------TEKFNHTIKMLFSQDYKMLEIVISNLKN--ANIELIHIESRQVNSKNYSDASMNGLIYNSLEILFVFNCTRRSYKEIIAKLIDEDKNYQKLTEFKIKDEIVDDIWIPKHISDLDNCNHLVLNF 742
            N      +K++S E+     RRS+++DA+F+  +  +           K N++   E+        +E  +    M  +     L+  IS+L      IE  H   + V S+    + + G+ ++   +L   + TR +  ++I  L  +  ++  +      +  V   W PKH S+LDNCNHL+  +
Sbjct:   10 NREMFAIKKSYSIENGYPSRRRSLVDDARFETLVVKQTKQTVLEEARSKANDYGLTEDEILLANAASESSDAEAAMQSAALVVRLKEGISSLGRILKAIETFHGTVQHVESRQ---SRVEGVDHD---VLIKLDMTRGNLLQLIRSL-RQSGSFSSMNLMADNNLNVKAPWFPKHASELDNCNHLMTKY 191
[Close]
BLAST of tyrosine hydroxylase vs. Ensembl Fly
Match: ple (gene:FBgn0005626 transcript:FBtr0076957)

HSP 1 Score: 47.7506 bits (112), Expect = 7.766e-11
Identity = 19/35 (54.29%), Postives = 29/35 (82.86%), Query Frame = 1 
Query:  736 EFQPEMASDHPGFHDKEYQKRRMEIAEIAFNFKHG 840
            +++P++  +HPGF DK Y++RR EIAEIAF +K+G
Sbjct:  261 KYEPDLDMNHPGFADKVYRQRRKEIAEIAFAYKYG 295

HSP 2 Score: 37.7354 bits (86), Expect = 7.766e-11
Identity = 24/87 (27.59%), Postives = 43/87 (49.43%), Query Frame = 2 
Query:  482 HIESRQVNSKNYSDASMNGLIYNSLEILFVFNCTRRSYKEIIAKLIDEDKNYQKLTEFKIKDEIVDDIWIPKHISDLDNCNHLVLNF 742
            H+ESRQ        + + G+ ++   +L   + TR +  ++I  L  +  ++  +      +  V   W PKH S+LDNCNHL+  +
Sbjct:  188 HVESRQ--------SRVEGVDHD---VLIKLDMTRGNLLQLIRSL-RQSGSFSSMNLMADNNLNVKAPWFPKHASELDNCNHLMTKY 262
[Close]
BLAST of tyrosine hydroxylase vs. Ensembl Fly
Match: ple (gene:FBgn0005626 transcript:FBtr0345585)

HSP 1 Score: 47.7506 bits (112), Expect = 7.766e-11
Identity = 19/35 (54.29%), Postives = 29/35 (82.86%), Query Frame = 1 
Query:  736 EFQPEMASDHPGFHDKEYQKRRMEIAEIAFNFKHG 840
            +++P++  +HPGF DK Y++RR EIAEIAF +K+G
Sbjct:  261 KYEPDLDMNHPGFADKVYRQRRKEIAEIAFAYKYG 295

HSP 2 Score: 37.7354 bits (86), Expect = 7.766e-11
Identity = 24/87 (27.59%), Postives = 43/87 (49.43%), Query Frame = 2 
Query:  482 HIESRQVNSKNYSDASMNGLIYNSLEILFVFNCTRRSYKEIIAKLIDEDKNYQKLTEFKIKDEIVDDIWIPKHISDLDNCNHLVLNF 742
            H+ESRQ        + + G+ ++   +L   + TR +  ++I  L  +  ++  +      +  V   W PKH S+LDNCNHL+  +
Sbjct:  188 HVESRQ--------SRVEGVDHD---VLIKLDMTRGNLLQLIRSL-RQSGSFSSMNLMADNNLNVKAPWFPKHASELDNCNHLMTKY 262
[Close]
BLAST of tyrosine hydroxylase vs. Ensembl Fly
Match: Hn (gene:FBgn0001208 transcript:FBtr0334645)

HSP 1 Score: 46.9802 bits (110), Expect = 6.305e-7
Identity = 19/31 (61.29%), Postives = 25/31 (80.65%), Query Frame = 1 
Query:  748 EMASDHPGFHDKEYQKRRMEIAEIAFNFKHG 840
            E+ +DHPGF D EY+KRR   A+IA+N+KHG
Sbjct:  140 ELDADHPGFTDPEYRKRRKYFADIAYNYKHG 170

HSP 2 Score: 25.0238 bits (53), Expect = 6.305e-7
Identity = 24/104 (23.08%), Postives = 41/104 (39.42%), Query Frame = 2 
Query:  443 VISNLKNANIELIHIESRQVNSKNYSDASMNGLIYNSLEILFVFNCTRRSYKEIIAKLIDEDK---NYQKLTEFKIKDEIVDDIWIPKHISDLDNCNHLVLNFN 745
            +++  K  +I L+HIESR       S   + G         + F          + K I++ K   +Y  +     KD      W P+ I DLD   + +L++ 
Sbjct:   51 ILAIFKKHDINLVHIESR-------SSLRVPG---------YEFFVEADGKSGALGKAIEDVKEQCSYFNIISRDYKDNATAVPWFPRRIRDLDRFANQILSYG 138
[Close]
BLAST of tyrosine hydroxylase vs. Ensembl Fly
Match: Hn (gene:FBgn0001208 transcript:FBtr0076811)

HSP 1 Score: 46.9802 bits (110), Expect = 6.305e-7
Identity = 19/31 (61.29%), Postives = 25/31 (80.65%), Query Frame = 1 
Query:  748 EMASDHPGFHDKEYQKRRMEIAEIAFNFKHG 840
            E+ +DHPGF D EY+KRR   A+IA+N+KHG
Sbjct:  140 ELDADHPGFTDPEYRKRRKYFADIAYNYKHG 170

HSP 2 Score: 25.0238 bits (53), Expect = 6.305e-7
Identity = 24/104 (23.08%), Postives = 41/104 (39.42%), Query Frame = 2 
Query:  443 VISNLKNANIELIHIESRQVNSKNYSDASMNGLIYNSLEILFVFNCTRRSYKEIIAKLIDEDK---NYQKLTEFKIKDEIVDDIWIPKHISDLDNCNHLVLNFN 745
            +++  K  +I L+HIESR       S   + G         + F          + K I++ K   +Y  +     KD      W P+ I DLD   + +L++ 
Sbjct:   51 ILAIFKKHDINLVHIESR-------SSLRVPG---------YEFFVEADGKSGALGKAIEDVKEQCSYFNIISRDYKDNATAVPWFPRRIRDLDRFANQILSYG 138
[Close]
BLAST of tyrosine hydroxylase vs. Ensembl Zebrafish
Match: th2 (tyrosine hydroxylase 2 [Source:ZFIN;Acc:ZDB-GENE-050201-1])

HSP 1 Score: 50.0618 bits (118), Expect = 9.606e-12
Identity = 20/35 (57.14%), Postives = 28/35 (80.00%), Query Frame = 1 
Query:  736 EFQPEMASDHPGFHDKEYQKRRMEIAEIAFNFKHG 840
            ++ P++  DHPGF D EY+KRR  I+E+AFN+KHG
Sbjct:  156 KYDPDLDQDHPGFSDSEYRKRRGFISEMAFNYKHG 190

HSP 2 Score: 38.5058 bits (88), Expect = 9.606e-12
Identity = 45/174 (25.86%), Postives = 73/174 (41.95%), Query Frame = 2 
Query:  284 RRSIIEDAKFDAALNSEFSNHFKNNE---FPDEEETEKFNHTIKMLFSQDYKMLEIVISNLKNAN------------IELIHIESRQVNSKNYSDAS-----MNGLIYNSLEILFVFNCTRRSYKEIIAKLIDEDKNYQKLTEFKIKDEIVDDIWIPKHISDLDNCNHLVLNFN 745
            +RS+IEDA+ D    S      +  +   F +EE+T K   T+ +LF+         + N KNA              +L+H+ESR       S        M   ++ S   +F+ N  +R   ++  +++ E+K                  W PK ISDLD CNHL+  ++
Sbjct:   16 KRSLIEDARRDRESGSSSPGPSRCGDSFVF-EEEKTGKI--TLNILFA---------LKNEKNAGFFKAGKVFETFETKLLHLESRASRKSKRSSGEDLEFFMRCEVHCSDTDIFI-NSLKRVADDV--RIVQEEKT----------------PWFPKKISDLDTCNHLITKYD 158
[Close]
BLAST of tyrosine hydroxylase vs. Ensembl Zebrafish
Match: tph2 (tryptophan hydroxylase 2 (tryptophan 5-monooxygenase) [Source:ZFIN;Acc:ZDB-GENE-040624-4])

HSP 1 Score: 40.0466 bits (92), Expect = 8.988e-9
Identity = 16/31 (51.61%), Postives = 22/31 (70.97%), Query Frame = 1 
Query:  748 EMASDHPGFHDKEYQKRRMEIAEIAFNFKHG 840
            E+ +DHPGF DK Y++RR    E+A N+K G
Sbjct:  157 ELDADHPGFKDKVYRQRRKYFVEVAMNYKFG 187

HSP 2 Score: 38.1206 bits (87), Expect = 8.988e-9
Identity = 40/165 (24.24%), Postives = 75/165 (45.45%), Query Frame = 2 
Query:  314 DAALNSEFSNHFKNNEFPDEEETEKFNH---TIKMLFS--QDYKMLEIVISNLKNANIELIHIESRQVNSKNYSDASMNGLIYNSLEILFVFNCTRRSYKEIIAKLIDEDKNYQKLTE---FKIKDEIVDDI-------------WIPKHISDLDNCNHLVLNFN 745
            ++ L+  +++  + +E PD+EE +K  H    + ++FS   +   L   +   +  ++ L HIESR+  SK  +         N +EI    NCT++ + E++  L D        T    +  + + +D +             W P+ IS+LD C+H VL + 
Sbjct:    3 NSTLHPPWTSFNRIDERPDKEE-QKSTHDLGKLAVIFSLKNEVGFLVKALRLFQEKHVNLAHIESRR--SKRLT---------NEIEIYAECNCTKKEFNELVQHLKDHVNIVSYNTPQHVWSAETDCLDCVCVLGGLPDGEGIPWFPQKISELDQCSHRVLMYG 155
[Close]
BLAST of tyrosine hydroxylase vs. Ensembl Zebrafish
Match: tph2 (tryptophan hydroxylase 2 (tryptophan 5-monooxygenase) [Source:ZFIN;Acc:ZDB-GENE-040624-4])

HSP 1 Score: 40.0466 bits (92), Expect = 1.594e-8
Identity = 16/31 (51.61%), Postives = 22/31 (70.97%), Query Frame = 1 
Query:  748 EMASDHPGFHDKEYQKRRMEIAEIAFNFKHG 840
            E+ +DHPGF DK Y++RR    E+A N+K G
Sbjct:  184 ELDADHPGFKDKVYRQRRKYFVEVAMNYKFG 214

HSP 2 Score: 37.3502 bits (85), Expect = 1.594e-8
Identity = 39/151 (25.83%), Postives = 67/151 (44.37%), Query Frame = 2 
Query:  356 NEFPDEEETEKFNH---TIKMLFS--QDYKMLEIVISNLKNANIELIHIESRQVNSKNYSDASMNGLIYNSLEILFVFNCTRRSYKEIIAKLIDEDKNYQKLTE---FKIKDEIVDDI-------------WIPKHISDLDNCNHLVLNFN 745
            +E PD+EE +K  H    + ++FS   +   L   +   +  ++ L HIESR+  SK  +         N +EI    NCT++ + E++  L D        T    +  + + +D +             W P+ IS+LD C+H VL + 
Sbjct:   44 DERPDKEE-QKSTHDLGKLAVIFSLKNEVGFLVKALRLFQEKHVNLAHIESRR--SKRLT---------NEIEIYAECNCTKKEFNELVQHLKDHVNIVSYNTPQHVWSAETDCLDCVCVLGGLPDGEGIPWFPQKISELDQCSHRVLMYG 182
[Close]
BLAST of tyrosine hydroxylase vs. Ensembl Zebrafish
Match: tph2 (tryptophan hydroxylase 2 (tryptophan 5-monooxygenase) [Source:ZFIN;Acc:ZDB-GENE-040624-4])

HSP 1 Score: 40.0466 bits (92), Expect = 2.016e-8
Identity = 16/31 (51.61%), Postives = 22/31 (70.97%), Query Frame = 1 
Query:  748 EMASDHPGFHDKEYQKRRMEIAEIAFNFKHG 840
            E+ +DHPGF DK Y++RR    E+A N+K G
Sbjct:  184 ELDADHPGFKDKVYRQRRKYFVEVAMNYKFG 214

HSP 2 Score: 36.965 bits (84), Expect = 2.016e-8
Identity = 39/151 (25.83%), Postives = 67/151 (44.37%), Query Frame = 2 
Query:  356 NEFPDEEETEKFNH---TIKMLFS--QDYKMLEIVISNLKNANIELIHIESRQVNSKNYSDASMNGLIYNSLEILFVFNCTRRSYKEIIAKLIDEDKNYQKLTE---FKIKDEIVDDI-------------WIPKHISDLDNCNHLVLNFN 745
            +E PD+EE +K  H    + ++FS   +   L   +   +  ++ L HIESR+  SK  +         N +EI    NCT++ + E++  L D        T    +  + + +D +             W P+ IS+LD C+H VL + 
Sbjct:   44 DERPDKEE-QKSTHDLGKLAVIFSLKNEVGYLVKALRLFQEKHVNLAHIESRR--SKRLT---------NEIEIYAECNCTKKEFNELVQHLKDHVNIVSYNTPQHVWSAETDCLDCVCVLGGLPDGEGIPWFPQKISELDQCSHRVLMYG 182
[Close]
BLAST of tyrosine hydroxylase vs. Ensembl Zebrafish
Match: th (tyrosine hydroxylase [Source:ZFIN;Acc:ZDB-GENE-990621-5])

HSP 1 Score: 44.669 bits (104), Expect = 3.919e-8
Identity = 17/35 (48.57%), Postives = 25/35 (71.43%), Query Frame = 1 
Query:  736 EFQPEMASDHPGFHDKEYQKRRMEIAEIAFNFKHG 840
            ++ P++  DHPGF D  Y+KRR  I +IAF ++HG
Sbjct:  174 KYDPDLDQDHPGFTDPVYRKRRKMIGDIAFKYRHG 208

HSP 2 Score: 31.5722 bits (70), Expect = 3.919e-8
Identity = 9/20 (45.00%), Postives = 15/20 (75.00%), Query Frame = 2 
Query:  686 WIPKHISDLDNCNHLVLNFN 745
            W P+ I++LD C+HLV  ++
Sbjct:  157 WFPRKIAELDKCHHLVTKYD 176
[Close]
BLAST of tyrosine hydroxylase vs. Ensembl Xenopus
Match: TH (tyrosine hydroxylase [Source:NCBI gene;Acc:100488900])

HSP 1 Score: 50.8322 bits (120), Expect = 2.268e-10
Identity = 20/35 (57.14%), Postives = 29/35 (82.86%), Query Frame = 1 
Query:  736 EFQPEMASDHPGFHDKEYQKRRMEIAEIAFNFKHG 840
            +F P++  +HPGF D+EY+KRR  IA+IAFN++HG
Sbjct:  176 KFDPDLDLEHPGFSDQEYRKRRKMIADIAFNYRHG 210

HSP 2 Score: 33.4982 bits (75), Expect = 2.268e-10
Identity = 11/20 (55.00%), Postives = 14/20 (70.00%), Query Frame = 2 
Query:  686 WIPKHISDLDNCNHLVLNFN 745
            W P  I+DLD C+HLV  F+
Sbjct:  159 WFPTKIADLDKCHHLVTKFD 178
[Close]
BLAST of tyrosine hydroxylase vs. Ensembl Xenopus
Match: TH (tyrosine hydroxylase [Source:NCBI gene;Acc:100488900])

HSP 1 Score: 50.8322 bits (120), Expect = 2.780e-10
Identity = 20/35 (57.14%), Postives = 29/35 (82.86%), Query Frame = 1 
Query:  736 EFQPEMASDHPGFHDKEYQKRRMEIAEIAFNFKHG 840
            +F P++  +HPGF D+EY+KRR  IA+IAFN++HG
Sbjct:  165 KFDPDLDLEHPGFSDQEYRKRRKMIADIAFNYRHG 199

HSP 2 Score: 33.4982 bits (75), Expect = 2.780e-10
Identity = 11/20 (55.00%), Postives = 14/20 (70.00%), Query Frame = 2 
Query:  686 WIPKHISDLDNCNHLVLNFN 745
            W P  I+DLD C+HLV  F+
Sbjct:  148 WFPTKIADLDKCHHLVTKFD 167
[Close]
BLAST of tyrosine hydroxylase vs. Ensembl Xenopus
Match: TPH2 (tryptophan hydroxylase 2 [Source:NCBI gene;Acc:100486097])

HSP 1 Score: 36.5798 bits (83), Expect = 8.053e-7
Identity = 13/31 (41.94%), Postives = 22/31 (70.97%), Query Frame = 1 
Query:  748 EMASDHPGFHDKEYQKRRMEIAEIAFNFKHG 840
            E+ +DHPGF D  Y++RR    ++A ++K+G
Sbjct:  169 ELDADHPGFKDNVYRQRRKYFVDVAMDYKYG 199

HSP 2 Score: 35.8094 bits (81), Expect = 8.053e-7
Identity = 29/100 (29.00%), Postives = 50/100 (50.00%), Query Frame = 2 
Query:  458 KNANIELIHIESRQVNSKNYSDASMNGLIYNSLEILFV-FNCTRRSYKEI--IAKLIDEDKNYQKLTEFKIKDEIVDDI-WIPKHISDLDNCNHLVLNFN 745
            K   + +IHIESR+ +  N S+  M           +V F CT++  +E+  + KL     +   +     KDE ++ + W P+ IS+LD C++ VL + 
Sbjct:   80 KEKYVNIIHIESRK-SKGNKSEVDM-----------YVEFECTKKKCQELQHLLKLQSGIISVNPVERIWRKDEELEGVLWFPRKISELDKCSNRVLMYG 167
[Close]
BLAST of tyrosine hydroxylase vs. Ensembl Mouse
Match: Th (tyrosine hydroxylase [Source:MGI Symbol;Acc:MGI:98735])

HSP 1 Score: 45.8246 bits (107), Expect = 3.134e-9
Identity = 19/35 (54.29%), Postives = 26/35 (74.29%), Query Frame = 1 
Query:  736 EFQPEMASDHPGFHDKEYQKRRMEIAEIAFNFKHG 840
            +F P++  DHPGF D+ Y++RR  IAEIAF +K G
Sbjct:  183 KFDPDLDLDHPGFSDQAYRQRRKLIAEIAFQYKQG 217

HSP 2 Score: 33.8834 bits (76), Expect = 3.134e-9
Identity = 10/20 (50.00%), Postives = 15/20 (75.00%), Query Frame = 2 
Query:  686 WIPKHISDLDNCNHLVLNFN 745
            W P+ +S+LD C+HLV  F+
Sbjct:  166 WFPRKVSELDKCHHLVTKFD 185
[Close]
BLAST of tyrosine hydroxylase vs. Ensembl Mouse
Match: Th (tyrosine hydroxylase [Source:MGI Symbol;Acc:MGI:98735])

HSP 1 Score: 46.2098 bits (108), Expect = 3.752e-9
Identity = 19/35 (54.29%), Postives = 26/35 (74.29%), Query Frame = 1 
Query:  736 EFQPEMASDHPGFHDKEYQKRRMEIAEIAFNFKHG 840
            +F P++  DHPGF D+ Y++RR  IAEIAF +K G
Sbjct:  183 KFDPDLDLDHPGFSDQAYRQRRKLIAEIAFQYKQG 217

HSP 2 Score: 33.4982 bits (75), Expect = 3.752e-9
Identity = 10/20 (50.00%), Postives = 15/20 (75.00%), Query Frame = 2 
Query:  686 WIPKHISDLDNCNHLVLNFN 745
            W P+ +S+LD C+HLV  F+
Sbjct:  166 WFPRKVSELDKCHHLVTKFD 185
[Close]
BLAST of tyrosine hydroxylase vs. Ensembl Mouse
Match: Th (tyrosine hydroxylase [Source:MGI Symbol;Acc:MGI:98735])

HSP 1 Score: 46.2098 bits (108), Expect = 4.982e-9
Identity = 19/35 (54.29%), Postives = 26/35 (74.29%), Query Frame = 1 
Query:  736 EFQPEMASDHPGFHDKEYQKRRMEIAEIAFNFKHG 840
            +F P++  DHPGF D+ Y++RR  IAEIAF +K G
Sbjct:   88 KFDPDLDLDHPGFSDQAYRQRRKLIAEIAFQYKQG 122

HSP 2 Score: 33.113 bits (74), Expect = 4.982e-9
Identity = 10/20 (50.00%), Postives = 15/20 (75.00%), Query Frame = 2 
Query:  686 WIPKHISDLDNCNHLVLNFN 745
            W P+ +S+LD C+HLV  F+
Sbjct:   71 WFPRKVSELDKCHHLVTKFD 90
[Close]
BLAST of tyrosine hydroxylase vs. Ensembl Mouse
Match: Tph1 (tryptophan hydroxylase 1 [Source:MGI Symbol;Acc:MGI:98796])

HSP 1 Score: 42.743 bits (99), Expect = 1.245e-7
Identity = 17/31 (54.84%), Postives = 23/31 (74.19%), Query Frame = 1 
Query:  748 EMASDHPGFHDKEYQKRRMEIAEIAFNFKHG 840
            E+ +DHPGF D  Y++RR   AE+A N+KHG
Sbjct:  131 ELDADHPGFKDNVYRRRRKYFAELAMNYKHG 161

HSP 2 Score: 31.9574 bits (71), Expect = 1.245e-7
Identity = 27/108 (25.00%), Postives = 48/108 (44.44%), Query Frame = 2 
Query:  443 VISNLKNANIELIHIESRQVNSKNYSDASMNGLIYNSLEILFVFNCTRRSYKEII------AKLIDEDKNYQKLTEFKIKDEIVDDI-WIPKHISDLDNCNHLVLNFN 745
            V+   +  ++ L+HIESR+   +N           +  EI    + +R    +I       A ++  D   Q       K+++++ + W PK ISDLD C + VL + 
Sbjct:   37 VLKIFQENHVSLLHIESRKSKQRN-----------SEFEIFVDCDISREQLNDIFPLLKSHATVLSVDSPDQ----LTAKEDVMETVPWFPKKISDLDFCANRVLLYG 129
[Close]
BLAST of tyrosine hydroxylase vs. Ensembl Mouse
Match: Tph1 (tryptophan hydroxylase 1 [Source:MGI Symbol;Acc:MGI:98796])

HSP 1 Score: 42.743 bits (99), Expect = 1.245e-7
Identity = 17/31 (54.84%), Postives = 23/31 (74.19%), Query Frame = 1 
Query:  748 EMASDHPGFHDKEYQKRRMEIAEIAFNFKHG 840
            E+ +DHPGF D  Y++RR   AE+A N+KHG
Sbjct:  131 ELDADHPGFKDNVYRRRRKYFAELAMNYKHG 161

HSP 2 Score: 31.9574 bits (71), Expect = 1.245e-7
Identity = 27/108 (25.00%), Postives = 48/108 (44.44%), Query Frame = 2 
Query:  443 VISNLKNANIELIHIESRQVNSKNYSDASMNGLIYNSLEILFVFNCTRRSYKEII------AKLIDEDKNYQKLTEFKIKDEIVDDI-WIPKHISDLDNCNHLVLNFN 745
            V+   +  ++ L+HIESR+   +N           +  EI    + +R    +I       A ++  D   Q       K+++++ + W PK ISDLD C + VL + 
Sbjct:   37 VLKIFQENHVSLLHIESRKSKQRN-----------SEFEIFVDCDISREQLNDIFPLLKSHATVLSVDSPDQ----LTAKEDVMETVPWFPKKISDLDFCANRVLLYG 129
[Close]
BLAST of tyrosine hydroxylase vs. UniProt/SwissProt
Match: sp|O17446|TY3H_SCHMA (Tyrosine 3-monooxygenase OS=Schistosoma mansoni OX=6183 GN=TH PE=2 SV=1)

HSP 1 Score: 54.299 bits (129), Expect = 4.871e-12
Identity = 22/35 (62.86%), Postives = 30/35 (85.71%), Query Frame = 1 
Query:  736 EFQPEMASDHPGFHDKEYQKRRMEIAEIAFNFKHG 840
            +FQPE+ +DHPGFHDK Y++RR  IA+IAF +K+G
Sbjct:  146 KFQPELQTDHPGFHDKVYRERREAIAKIAFQYKYG 180

HSP 2 Score: 38.1206 bits (87), Expect = 4.871e-12
Identity = 17/26 (65.38%), Postives = 18/26 (69.23%), Query Frame = 2 
Query:  686 WIPKHISDLDNCNHLVLNFNQKWLQT 763
            W PKHISDLD C HL+  F Q  LQT
Sbjct:  129 WYPKHISDLDKCQHLLRKF-QPELQT 153
[Close]
BLAST of tyrosine hydroxylase vs. UniProt/SwissProt
Match: sp|P18459|TY3H_DROME (Tyrosine 3-monooxygenase OS=Drosophila melanogaster OX=7227 GN=ple PE=2 SV=2)

HSP 1 Score: 47.7506 bits (112), Expect = 5.765e-10
Identity = 19/35 (54.29%), Postives = 29/35 (82.86%), Query Frame = 1 
Query:  736 EFQPEMASDHPGFHDKEYQKRRMEIAEIAFNFKHG 840
            +++P++  +HPGF DK Y++RR EIAEIAF +K+G
Sbjct:  261 KYEPDLDMNHPGFADKVYRQRRKEIAEIAFAYKYG 295

HSP 2 Score: 37.7354 bits (86), Expect = 5.765e-10
Identity = 24/87 (27.59%), Postives = 43/87 (49.43%), Query Frame = 2 
Query:  482 HIESRQVNSKNYSDASMNGLIYNSLEILFVFNCTRRSYKEIIAKLIDEDKNYQKLTEFKIKDEIVDDIWIPKHISDLDNCNHLVLNF 742
            H+ESRQ        + + G+ ++   +L   + TR +  ++I  L  +  ++  +      +  V   W PKH S+LDNCNHL+  +
Sbjct:  188 HVESRQ--------SRVEGVDHD---VLIKLDMTRGNLLQLIRSL-RQSGSFSSMNLMADNNLNVKAPWFPKHASELDNCNHLMTKY 262
[Close]
BLAST of tyrosine hydroxylase vs. UniProt/SwissProt
Match: sp|Q76IQ3|TY3H_CANLF (Tyrosine 3-monooxygenase OS=Canis lupus familiaris OX=9615 GN=TH PE=2 SV=1)

HSP 1 Score: 48.521 bits (114), Expect = 2.759e-9
Identity = 20/35 (57.14%), Postives = 27/35 (77.14%), Query Frame = 1 
Query:  736 EFQPEMASDHPGFHDKEYQKRRMEIAEIAFNFKHG 840
            +F P++  DHPGF D+ Y++RR  IAEIAF +KHG
Sbjct:  180 KFDPDLDLDHPGFSDQVYRQRRKLIAEIAFQYKHG 214

HSP 2 Score: 34.2686 bits (77), Expect = 2.759e-9
Identity = 10/21 (47.62%), Postives = 16/21 (76.19%), Query Frame = 2 
Query:  683 IWIPKHISDLDNCNHLVLNFN 745
            +W P+ +S+LD C+HLV  F+
Sbjct:  162 LWFPRKVSELDKCHHLVTKFD 182
[Close]
BLAST of tyrosine hydroxylase vs. UniProt/SwissProt
Match: sp|P04177|TY3H_RAT (Tyrosine 3-monooxygenase OS=Rattus norvegicus OX=10116 GN=Th PE=1 SV=3)

HSP 1 Score: 48.1358 bits (113), Expect = 5.919e-9
Identity = 20/35 (57.14%), Postives = 27/35 (77.14%), Query Frame = 1 
Query:  736 EFQPEMASDHPGFHDKEYQKRRMEIAEIAFNFKHG 840
            +F P++  DHPGF D+ Y++RR  IAEIAF +KHG
Sbjct:  183 KFDPDLDLDHPGFSDQVYRQRRKLIAEIAFQYKHG 217

HSP 2 Score: 33.4982 bits (75), Expect = 5.919e-9
Identity = 10/20 (50.00%), Postives = 15/20 (75.00%), Query Frame = 2 
Query:  686 WIPKHISDLDNCNHLVLNFN 745
            W P+ +S+LD C+HLV  F+
Sbjct:  166 WFPRKVSELDKCHHLVTKFD 185
[Close]
BLAST of tyrosine hydroxylase vs. UniProt/SwissProt
Match: sp|O42091|TY3H_ANGAN (Tyrosine 3-monooxygenase OS=Anguilla anguilla OX=7936 GN=th PE=2 SV=1)

HSP 1 Score: 46.2098 bits (108), Expect = 6.967e-9
Identity = 19/35 (54.29%), Postives = 25/35 (71.43%), Query Frame = 1 
Query:  736 EFQPEMASDHPGFHDKEYQKRRMEIAEIAFNFKHG 840
            +F P++  DHPGF D  Y++RR  I EIAF +KHG
Sbjct:  173 KFDPDLDQDHPGFTDPVYRQRRRMIGEIAFRYKHG 207

HSP 2 Score: 35.039 bits (79), Expect = 6.967e-9
Identity = 12/20 (60.00%), Postives = 16/20 (80.00%), Query Frame = 2 
Query:  686 WIPKHISDLDNCNHLVLNFN 745
            W PK IS+LD+C+HLV  F+
Sbjct:  156 WFPKKISELDSCHHLVTKFD 175
[Close]
BLAST of tyrosine hydroxylase vs. TrEMBL
Match: F6KBQ1 (Tyrosine hydroxylase (Fragment) OS=Schmidtea mediterranea OX=79327 GN=th PE=2 SV=1)

HSP 1 Score: 290.426 bits (742), Expect = 5.134e-93
Identity = 142/143 (99.30%), Postives = 142/143 (99.30%), Query Frame = 2 
Query:  314 DAALNSEFSNHFKNNEFPDEEETEKFNHTIKMLFSQDYKMLEIVISNLKNANIELIHIESRQVNSKNYSDASMNGLIYNSLEILFVFNCTRRSYKEIIAKLIDEDKNYQKLTEFKIKDEIVDDIWIPKHISDLDNCNHLVLNF 742
            DAALNSEFSNHFKNNEFPDEEETEKFNHTIKMLFSQDYKMLEIVISNLKNANIELIHIESRQVNSKNYSDASMNGLIYNSLEILFVFNCTRRSYKEIIAKLIDEDKNYQKLTEFKIKDEIVDDIWIPKHISDLDNCNHLVL F
Sbjct:    1 DAALNSEFSNHFKNNEFPDEEETEKFNHTIKMLFSQDYKMLEIVISNLKNANIELIHIESRQVNSKNYSDASMNGLIYNSLEILFVFNCTRRSYKEIIAKLIDEDKNYQKLTEFKIKDEIVDDIWIPKHISDLDNCNHLVLKF 143

HSP 2 Score: 76.6406 bits (187), Expect = 3.711e-12
Identity = 34/36 (94.44%), Postives = 35/36 (97.22%), Query Frame = 1 
Query:  733 FEFQPEMASDHPGFHDKEYQKRRMEIAEIAFNFKHG 840
             +FQPEMASDHPGFHDKEYQKRRMEIAEIAFNFKHG
Sbjct:  141 LKFQPEMASDHPGFHDKEYQKRRMEIAEIAFNFKHG 176
[Close]
BLAST of tyrosine hydroxylase vs. TrEMBL
Match: A6P4D3 (Tyrosine hydroxylase OS=Dugesia japonica OX=6161 GN=DjTH PE=2 SV=1)

HSP 1 Score: 264.233 bits (674), Expect = 5.874e-82
Identity = 133/176 (75.57%), Postives = 154/176 (87.50%), Query Frame = 2 
Query:  215 MSYNSRRLQFQKTFSYEHQSEFHRRSIIEDAKFDAALNSEFSNHFKNNEFPDEEETEKFNHTIKMLFSQDYKMLEIVISNLKNANIELIHIESRQVNSKNYSDASMNGLIYNSLEILFVFNCTRRSYKEIIAKLIDEDKNYQKLTEFKIKDEIVDDIWIPKHISDLDNCNHLVLNF 742
            MSY SRRLQFQKTFSYE  SEF  RSIIEDAK+DAALNSEFSNHFKN +F ++EE  K+NHTIKMLF QDY++LE+VI+NLK A+IELIHIESR  NSK+YSDA++NGLI NSLEILFVFNCT+++YK+II  L  EDK YQKLT+ KIKDEI +DIWIPKHISDLD+CNHL+L F
Sbjct:    1 MSYKSRRLQFQKTFSYE--SEFLHRSIIEDAKYDAALNSEFSNHFKNKDFSEDEE--KYNHTIKMLFHQDYRLLEMVINNLKIADIELIHIESRLFNSKDYSDATINGLIPNSLEILFVFNCTKKAYKDIIENLSKEDKEYQKLTDLKIKDEIAEDIWIPKHISDLDSCNHLMLKF 172

HSP 2 Score: 68.9366 bits (167), Expect = 1.836e-9
Identity = 30/36 (83.33%), Postives = 33/36 (91.67%), Query Frame = 1 
Query:  733 FEFQPEMASDHPGFHDKEYQKRRMEIAEIAFNFKHG 840
             +FQPEMASDHPGFHDK Y+ RRMEIAEIAFNFK+G
Sbjct:  170 LKFQPEMASDHPGFHDKIYKSRRMEIAEIAFNFKYG 205
[Close]
BLAST of tyrosine hydroxylase vs. TrEMBL
Match: K1QYX8 (Tyrosine 3-monooxygenase OS=Crassostrea gigas OX=29159 GN=CGI_10021437 PE=4 SV=1)

HSP 1 Score: 86.2705 bits (212), Expect = 2.825e-24
Identity = 57/190 (30.00%), Postives = 89/190 (46.84%), Query Frame = 2 
Query:  230 RRLQFQKTFSYEHQSEFHRRSIIEDAKFDAALNSEFSNHFKN----NEFPDEEETEKFNHTIKMLFSQDYKMLEIVISNLKNA---------------NIELIHIESRQVNSKNYSDASMNGLIYNSLEILFVFNCTRRSYKEIIAKLIDEDKNYQKLTEFKIKDEIVDDIWIPKHISDLDNCNHLVLNF 742
            RRL FQK++S EH   + R+S+IEDA+F+   N EF+   +         +EEE    N         D   L +++  LK                  + L HIESR+ +          G I++   +L  F C+R+    ++   I ++ + +++T    KD  + D W P+HIS+LDNC HLV  F
Sbjct:   20 RRLAFQKSYSQEHGGSWRRKSLIEDARFETVTNIEFAKRERTISNRGSISEEEEVFTQNGDTPSPVETDPSRLYVILVTLKEGMTASLSRIVRVFETTKVFLDHIESRKSHKA--------GAIFD---VLIQFVCSRQKVTSLM-NAIRQNPSVEEVTVIGDKDADIQDAWFPRHISELDNCTHLVTKF 197

HSP 2 Score: 55.0694 bits (131), Expect = 2.825e-24
Identity = 22/35 (62.86%), Postives = 30/35 (85.71%), Query Frame = 1 
Query:  736 EFQPEMASDHPGFHDKEYQKRRMEIAEIAFNFKHG 840
            +F+PE+  DHPGF D+EY+KRR +IA+IAF +KHG
Sbjct:  196 KFEPELDCDHPGFTDEEYKKRRKQIADIAFEYKHG 230
[Close]
BLAST of tyrosine hydroxylase vs. TrEMBL
Match: A0A1S3HUS1 (phenylalanine-4-hydroxylase OS=Lingula unguis OX=7574 GN=LOC106158393 PE=4 SV=1)

HSP 1 Score: 70.8626 bits (172), Expect = 6.021e-20
Identity = 51/189 (26.98%), Postives = 83/189 (43.92%), Query Frame = 2 
Query:  230 RRLQFQKTFSYEHQSEFHRRSIIEDAKFDAALNSEFSNHFK----NNEFPDE--------------EETEKFNHTIKMLFSQDYKMLEIVISNLKNANIELIHIESRQVNSKNYSDASMNGLIYNSLEILFVFNCTRRSYKEIIAKLIDEDKNYQKLTEFKIKDEIVDDIWIPKHISDLDNCNHLVLNF 742
            RRL FQK++S EH   + R+S+I+DAKF+   N+EF    +    N    ++              ++    + ++ +   ++   L  ++   +N  + + HIESR  NS+          I    EI    + TR +   ++  L       +       K E V   W+P HISDLD CNHL+  F
Sbjct:   12 RRLAFQKSYSIEHGGSWRRKSLIDDAKFETITNAEFEKQEQKLTLNGSISEDDVFIPNGDAHNILHDDLAPRSSSVMLSLKEEMTALPKILKTFENFKVNIRHIESR--NSRK---------IEAQFEIFLQCDSTREAITSLMKALRQNSAICEATVSGDTKKESV--AWVPMHISDLDYCNHLITKF 187

HSP 2 Score: 55.8398 bits (133), Expect = 6.021e-20
Identity = 23/35 (65.71%), Postives = 30/35 (85.71%), Query Frame = 1 
Query:  736 EFQPEMASDHPGFHDKEYQKRRMEIAEIAFNFKHG 840
            +F+PE+ SDHPG+ DKEY+KRR EIA IAF ++HG
Sbjct:  186 KFEPELDSDHPGYTDKEYRKRREEIANIAFEYRHG 220
[Close]
BLAST of tyrosine hydroxylase vs. TrEMBL
Match: A0A210Q5A7 (Tyrosine 3-monooxygenase OS=Mizuhopecten yessoensis OX=6573 GN=KP79_PYT06628 PE=4 SV=1)

HSP 1 Score: 72.0182 bits (175), Expect = 1.455e-17
Identity = 58/199 (29.15%), Postives = 82/199 (41.21%), Query Frame = 2 
Query:  230 RRLQFQKTFSYEHQSEFHRRSIIEDAKFDAALNSEFSNHFK------------------------NNEFPDEEETEKF-NHTIKMLFSQDYKMLEIVISNLKNANIELIHIESRQVNSKNYSDASMNGLIYNSLEILF--VFNCTRRSYKEIIAKLIDEDKNYQKLTEFKIKDEIVD-DIWIPKHISDLDNCNHLVLNF 742
            RRL FQK++S EH   + RRS+IEDAKF++  N EF+   K                        N + P   ET    N TI +  +     L  ++   +N  + + HIESR+    +              EIL   V  C R +    +  L+ +      +     +    + D W P HISDLDNC HLV  F
Sbjct:   22 RRLAFQKSYSQEHGGSWRRRSLIEDAKFESVTNKEFNKREKHLSVKEKSVNTTGSISEEEEVFVQNGDGPSPVETGNLVNITIVITLNDGISSLAKILRVFENTKVTIDHIESRKSKKPDC-----------QYEILLQAVSTCERWT---PVTNLLRQSPQVNDILILNEQPRPAEKDDWYPHHISDLDNCTHLVTKF 206

HSP 2 Score: 46.595 bits (109), Expect = 1.455e-17
Identity = 18/35 (51.43%), Postives = 29/35 (82.86%), Query Frame = 1 
Query:  736 EFQPEMASDHPGFHDKEYQKRRMEIAEIAFNFKHG 840
            +F+P++  DHPGF D +Y++RR EIA+IAF +++G
Sbjct:  205 KFEPDLDHDHPGFTDMKYRERRKEIADIAFEYRNG 239
[Close]
BLAST of tyrosine hydroxylase vs. Ensembl Cavefish
Match: th2 (tyrosine hydroxylase 2 [Source:ZFIN;Acc:ZDB-GENE-050201-1])

HSP 1 Score: 52.7582 bits (125), Expect = 3.278e-12
Identity = 20/35 (57.14%), Postives = 29/35 (82.86%), Query Frame = 1 
Query:  736 EFQPEMASDHPGFHDKEYQKRRMEIAEIAFNFKHG 840
            ++ P++  DHPGF D EY+KRR +I+E+AFN+KHG
Sbjct:  162 KYDPDLDQDHPGFSDLEYRKRRAQISELAFNYKHG 196

HSP 2 Score: 36.965 bits (84), Expect = 3.278e-12
Identity = 43/179 (24.02%), Postives = 78/179 (43.58%), Query Frame = 2 
Query:  284 RRSIIEDAKFDA-------ALNSEFSNHFKNNEFPDEEETEKFNHTIKMLFSQDYKMLEIVISNLKNAN------------IELIHIESRQVNSKNYSDAS------MNGLIYNSLEILFVFNCTRRSYKEIIAKLIDEDKNYQKLTEFKIKDEIVDDIWIPKHISDLDNCNHLVLNFN 745
            +RS+IEDA+ +        + ++        + F  EE++ K   T+ +LF+         + N KNA              +L+H+ESR       S +S      M   +++S +I F+ N  +R  +++  +++ E+K                  W P+ ISDLD CNHL+  ++
Sbjct:   16 KRSLIEDARREREKERERESTSASPGPSPSGDNFVFEEKSGKV--TLSVLFA---------LKNEKNAGFFKAGKVFETFETKLLHLESRPCRRSKNSLSSDDLEFFMKCEVHSS-DIDFLINSLKRVAEDV--RIVQEEKV----------------PWFPRKISDLDKCNHLITKYD 164
[Close]
BLAST of tyrosine hydroxylase vs. Ensembl Cavefish
Match: th (tyrosine hydroxylase [Source:NCBI gene;Acc:103023599])

HSP 1 Score: 46.9802 bits (110), Expect = 1.483e-9
Identity = 18/35 (51.43%), Postives = 26/35 (74.29%), Query Frame = 1 
Query:  736 EFQPEMASDHPGFHDKEYQKRRMEIAEIAFNFKHG 840
            +F P++  DHPGF D  Y+KRR +I +IAF ++HG
Sbjct:  178 KFDPDLDQDHPGFTDPVYRKRRKQIGDIAFKYRHG 212

HSP 2 Score: 33.8834 bits (76), Expect = 1.483e-9
Identity = 11/20 (55.00%), Postives = 15/20 (75.00%), Query Frame = 2 
Query:  686 WIPKHISDLDNCNHLVLNFN 745
            W PK I++LD C+HLV  F+
Sbjct:  161 WFPKKIAELDRCHHLVTKFD 180
[Close]
BLAST of tyrosine hydroxylase vs. Ensembl Cavefish
Match: th (tyrosine hydroxylase [Source:NCBI gene;Acc:103023599])

HSP 1 Score: 46.9802 bits (110), Expect = 1.618e-9
Identity = 18/35 (51.43%), Postives = 26/35 (74.29%), Query Frame = 1 
Query:  736 EFQPEMASDHPGFHDKEYQKRRMEIAEIAFNFKHG 840
            +F P++  DHPGF D  Y+KRR +I +IAF ++HG
Sbjct:  202 KFDPDLDQDHPGFTDPVYRKRRKQIGDIAFKYRHG 236

HSP 2 Score: 33.4982 bits (75), Expect = 1.618e-9
Identity = 11/21 (52.38%), Postives = 15/21 (71.43%), Query Frame = 2 
Query:  686 WIPKHISDLDNCNHLVLNFNQ 748
            W PK I++LD C+HLV  F+ 
Sbjct:  185 WFPKKIAELDRCHHLVTKFDP 205
[Close]
BLAST of tyrosine hydroxylase vs. Ensembl Cavefish
Match: th (tyrosine hydroxylase [Source:NCBI gene;Acc:103023599])

HSP 1 Score: 46.9802 bits (110), Expect = 1.744e-9
Identity = 18/35 (51.43%), Postives = 26/35 (74.29%), Query Frame = 1 
Query:  736 EFQPEMASDHPGFHDKEYQKRRMEIAEIAFNFKHG 840
            +F P++  DHPGF D  Y+KRR +I +IAF ++HG
Sbjct:  177 KFDPDLDQDHPGFTDPVYRKRRKQIGDIAFKYRHG 211

HSP 2 Score: 33.4982 bits (75), Expect = 1.744e-9
Identity = 11/20 (55.00%), Postives = 15/20 (75.00%), Query Frame = 2 
Query:  686 WIPKHISDLDNCNHLVLNFN 745
            W PK I++LD C+HLV  F+
Sbjct:  160 WFPKKIAELDRCHHLVTKFD 179
[Close]
BLAST of tyrosine hydroxylase vs. Ensembl Cavefish
Match: tph1b (tryptophan 5-hydroxylase 1-like [Source:NCBI gene;Acc:103025693])

HSP 1 Score: 40.0466 bits (92), Expect = 2.618e-9
Identity = 16/30 (53.33%), Postives = 22/30 (73.33%), Query Frame = 1 
Query:  751 MASDHPGFHDKEYQKRRMEIAEIAFNFKHG 840
            + +DHPGF D  Y+KRR   A++A N+KHG
Sbjct:  166 LDADHPGFKDNVYRKRRKYFADLAMNYKHG 195

HSP 2 Score: 39.6614 bits (91), Expect = 2.618e-9
Identity = 30/97 (30.93%), Postives = 47/97 (48.45%), Query Frame = 2 
Query:  470 IELIHIESRQVNSKNYSDASMNGLIYNSLEILFVFNCTRRSYKEIIAKLIDEDKNYQKL--TEFKIKDEIVD---DIWIPKHISDLDNCNHLVLNFN 745
            ++L+HIESR+    N           + LE+L   +  R + KEII +L+ +  N   +   E  + D   D   + W P+ ISDLD C + VL + 
Sbjct:   79 VKLLHIESRKSRRNN-----------SELEVLVDCDSERDTLKEII-QLLKKQTNTVTMDPPERPLPDPDTDFPEEPWFPRKISDLDKCANRVLMYG 163
[Close]
BLAST of tyrosine hydroxylase vs. Ensembl Sea Lamprey
Match: tph1a (tryptophan hydroxylase 1 (tryptophan 5-monooxygenase) a [Source:ZFIN;Acc:ZDB-GENE-030317-1])

HSP 1 Score: 42.743 bits (99), Expect = 1.920e-7
Identity = 17/31 (54.84%), Postives = 23/31 (74.19%), Query Frame = 1 
Query:  748 EMASDHPGFHDKEYQKRRMEIAEIAFNFKHG 840
            ++ +DHPGF D  Y+KRR   A+IA N+KHG
Sbjct:  169 DLDADHPGFKDNVYRKRRKHFADIALNYKHG 199

HSP 2 Score: 28.4906 bits (62), Expect = 1.920e-7
Identity = 24/98 (24.49%), Postives = 43/98 (43.88%), Query Frame = 2 
Query:  467 NIELIHIESRQVNSKNYSDASMNGLIYNSLEILFVFNCTRRSYKEIIAKLIDEDKNYQKLTE----FKIKDEIVDDI-WIPKHISDLDNCNHLVLNFN 745
            ++ L+HIESR+   +N           +  EI    +  R    E++  L     N   ++       +  + +D + W PK ISDLD+ ++ VL + 
Sbjct:   81 HVNLMHIESRKSKRRN-----------SEFEIYVDCDSNREQLGELMQLLRSHACNIVSMSGPASHCDVGPQDLDGVPWFPKKISDLDHSSNKVLMYG 167
[Close]
BLAST of tyrosine hydroxylase vs. Ensembl Nematostella
Match: EDO31745 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7SX22])

HSP 1 Score: 43.1282 bits (100), Expect = 1.243e-6
Identity = 19/31 (61.29%), Postives = 23/31 (74.19%), Query Frame = 1 
Query:  748 EMASDHPGFHDKEYQKRRMEIAEIAFNFKHG 840
            E+ SDHPGF D+ Y+ RR E A+IAF  KHG
Sbjct:  134 ELDSDHPGFTDQVYRARRKEFADIAFKHKHG 164

HSP 2 Score: 26.1794 bits (56), Expect = 1.243e-6
Identity = 32/128 (25.00%), Postives = 53/128 (41.41%), Query Frame = 2 
Query:  371 EEETEKFNHTIKMLFSQDYKMLEIVISNLKNANIELIHIESRQVNS-KNYSD--ASMNGLIYNSLEILFVFNCTRRSYKEIIAKLIDEDKNYQKLTEFKIKDEIVDDIWIPKHISDLDNCNHLVLNFN 745
            E E+EK   T+    +++   L   +   ++ ++ + HIESR   + K   D  A   GL   SL   FV    +R+   +   ++ +DK                  W P+ ISDLD     VL++ 
Sbjct:   23 EGESEKKATTVVFSLNEEVGALARALKLFEDHHVNMTHIESRPSKACKTRYDFFADCEGLHGASLN-HFVDALKKRA---VNITVLSDDKGSVP--------------WFPRKISDLDKFADRVLSYG 132
[Close]
BLAST of tyrosine hydroxylase vs. Ensembl Medaka
Match: tph2 (tryptophan hydroxylase 2 [Source:NCBI gene;Acc:101166957])

HSP 1 Score: 43.5134 bits (101), Expect = 7.206e-10
Identity = 40/160 (25.00%), Postives = 66/160 (41.25%), Query Frame = 2 
Query:  281 HRRSIIEDAKFDAALNSEFSNHFKNNEFPDEEETEKFNHTIKMLFS--QDYKMLEIVISNLKNANIELIHIESRQVNSKNYSDASMNGLIYNSLEILFVFNCTRRSYKEIIAKLIDEDKNYQKLTEFKIKDEIVDD---IWIPKHISDLDNCNHLVLNFN 745
            HR   +   K      S  ++    NE PD E  E    T  ++FS   +   L   +   +   + L HIESR           ++  + N +EI    +C+++ ++E++  L D        T   +  +  DD    W P  IS+LD C+H VL + 
Sbjct:   45 HRNQNLPQQKHTGGQMSRRTSFCPINERPDHEAAEDSGKT-AVVFSLKNEVGFLVKALQLFQEKRVNLNHIESR-----------VSKRVPNEVEIFADCSCSQKEFEELLQLLRDSVSVVSTNTPAHVWADDADDEDVPWFPMKISELDQCSHRVLMYG 192

HSP 2 Score: 38.5058 bits (88), Expect = 7.206e-10
Identity = 15/31 (48.39%), Postives = 22/31 (70.97%), Query Frame = 1 
Query:  748 EMASDHPGFHDKEYQKRRMEIAEIAFNFKHG 840
            E+ +DHPGF D+ Y++RR    E+A N+K G
Sbjct:  194 ELDADHPGFKDEVYRRRRKYFVEVAMNYKFG 224
[Close]
BLAST of tyrosine hydroxylase vs. Ensembl Medaka
Match: th2 (tyrosine 3-monooxygenase-like [Source:NCBI gene;Acc:101168664])

HSP 1 Score: 46.2098 bits (108), Expect = 1.016e-9
Identity = 18/35 (51.43%), Postives = 26/35 (74.29%), Query Frame = 1 
Query:  736 EFQPEMASDHPGFHDKEYQKRRMEIAEIAFNFKHG 840
            +F P++   HPG++D EY+KRR  I E+AF +KHG
Sbjct:  153 KFDPDLDHGHPGYNDSEYRKRRAAIIELAFRYKHG 187

HSP 2 Score: 35.4242 bits (80), Expect = 1.016e-9
Identity = 42/175 (24.00%), Postives = 72/175 (41.14%), Query Frame = 2 
Query:  284 RRSIIEDAKFD---AALNSEFSNHFKNNEFPDEEETEKFNHTIKMLFSQDYKMLEIVISNLKNANI------------ELIHIESRQVNS-KNYSDASMNGLIYNSLEILFVFNCTRRS-----YKEIIAKLIDEDKNYQKLTEFKIKDEIVDDIWIPKHISDLDNCNHLVLNFN 745
            ++S+IEDA+ +   A   S   +   +    +E++ +    T+ +LF+         +S  KNA              +L+HIESR     KN           N  ++ F   C  +S     +   + ++ D+ ++Y    E K+        W PK I DLD CN L+  F+
Sbjct:   14 KQSLIEDARRERACAPAGSPGPSRLGDGSVFEEKDGKV---TLNVLFA---------LSGQKNAGFFKAGKIFETFEAKLLHIESRPGRKWKN-----------NGPDLEFFMRCEVQSSDLDVFLNTLKRVADDVRSY---PEEKVP-------WFPKQIKDLDRCNVLITKFD 155
[Close]
BLAST of tyrosine hydroxylase vs. Ensembl Medaka
Match: th (tyrosine hydroxylase [Source:NCBI gene;Acc:101171548])

HSP 1 Score: 45.4394 bits (106), Expect = 1.586e-9
Identity = 18/35 (51.43%), Postives = 25/35 (71.43%), Query Frame = 1 
Query:  736 EFQPEMASDHPGFHDKEYQKRRMEIAEIAFNFKHG 840
            +F P++  DHPGF D  Y++RR  I  IAF++KHG
Sbjct:  174 KFDPDLDQDHPGFTDPVYRQRRQMIGNIAFSYKHG 208

HSP 2 Score: 35.4242 bits (80), Expect = 1.586e-9
Identity = 12/20 (60.00%), Postives = 15/20 (75.00%), Query Frame = 2 
Query:  686 WIPKHISDLDNCNHLVLNFN 745
            W PK I+DLD C+HLV  F+
Sbjct:  157 WFPKKIADLDKCHHLVTKFD 176
[Close]
BLAST of tyrosine hydroxylase vs. Ensembl Medaka
Match: pah (phenylalanine hydroxylase [Source:NCBI gene;Acc:101163702])

HSP 1 Score: 44.669 bits (104), Expect = 1.550e-7
Identity = 17/36 (47.22%), Postives = 26/36 (72.22%), Query Frame = 1 
Query:  733 FEFQPEMASDHPGFHDKEYQKRRMEIAEIAFNFKHG 840
              +  E+ +DHPGF D+ Y+ RR E A+IA+N++HG
Sbjct:  190 LSYGSELDADHPGFTDQVYRARRKEFADIAYNYRHG 225

HSP 2 Score: 29.261 bits (64), Expect = 1.550e-7
Identity = 35/128 (27.34%), Postives = 56/128 (43.75%), Query Frame = 2 
Query:  371 EEETEKFNHTIKMLFS--QDYKMLEIVISNLKNANIELIHIESRQVNSKNYSDASMNGLIYNSLEILFVFNCTRRSYKEIIAKLIDE-DKNYQKLTEFKIKDEIVDDIWIPKHISDLDNCNHLVLNFN 745
            EEET K +  I  +FS  ++   L   +   ++  I L HIESR         + MNG  Y     + V +   ++  ++I  L  E   +   L+  K KD +    W P  I DLD   + +L++ 
Sbjct:   80 EEETNK-SGVISCIFSLKEEVGALAKALRLFEDNGINLTHIESR--------PSRMNGEEYEFF--ISVESSCSQALDDVIDGLRKEISGHVHGLSRNKQKDTVP---WFPNDIQDLDRFANQILSYG 193
[Close]
BLAST of tyrosine hydroxylase vs. Ensembl Medaka
Match: tph1b (tryptophan 5-hydroxylase 1 [Source:NCBI gene;Acc:101170994])

HSP 1 Score: 41.2022 bits (95), Expect = 1.688e-7
Identity = 16/31 (51.61%), Postives = 22/31 (70.97%), Query Frame = 1 
Query:  748 EMASDHPGFHDKEYQKRRMEIAEIAFNFKHG 840
            ++ +DHPGF D  Y+KRR   A++A  FKHG
Sbjct:  130 DLDADHPGFKDSVYRKRRQYFADVAMTFKHG 160

HSP 2 Score: 32.7278 bits (73), Expect = 1.688e-7
Identity = 29/137 (21.17%), Postives = 53/137 (38.69%), Query Frame = 2 
Query:  368 DEEETEKFNHTIKMLFSQDYKMLEIVISNLKNANIELIHIESRQVNSKNYSDASMNGLIYNSLEILFVFNCTRRSYKEIIAKLIDEDKNYQKLTEFKIKDEIVDD-----------IWIPKHISDLDNCNHLVLNFN 745
            D + ++K   TI      +   L   +   +  ++ L+HIESR+   ++           +  E+    +      KE+  +L+       ++T F     + +D            W PK ISDLD C + VL + 
Sbjct:    4 DNKGSQKRTATIIFTLKNEVGGLIKALKLFQEKHVHLVHIESRKSRRRD-----------SDFEVFVDCDSEHEQMKEL-TQLLSTHAQIVEITPFGGCSPLAEDDRADAPEADGVPWFPKKISDLDQCANRVLMYG 128
[Close]
BLAST of tyrosine hydroxylase vs. Planmine SMEST
Match: SMESG000034472.1 (SMESG000034472.1)

HSP 1 Score: 357.836 bits (917), Expect = 5.019e-122
Identity = 175/176 (99.43%), Postives = 175/176 (99.43%), Query Frame = 2 
Query:  215 MSYNSRRLQFQKTFSYEHQSEFHRRSIIEDAKFDAALNSEFSNHFKNNEFPDEEETEKFNHTIKMLFSQDYKMLEIVISNLKNANIELIHIESRQVNSKNYSDASMNGLIYNSLEILFVFNCTRRSYKEIIAKLIDEDKNYQKLTEFKIKDEIVDDIWIPKHISDLDNCNHLVLNF 742
            MSYNSRRLQFQKTFSYEHQSEFHRRSIIEDAKFDAALNSEFSNHFKNNEFPDEEETEKFNHTIKMLFSQDYKMLEIVISNLKNANIELIHIESRQVNSKNYSDASMNGLIYNSLEILFVFNCTRRSYKEIIAKLIDEDKNYQKLTEFKIKDEIVDDIWIPKHISDLDNCNHLVL F
Sbjct:    1 MSYNSRRLQFQKTFSYEHQSEFHRRSIIEDAKFDAALNSEFSNHFKNNEFPDEEETEKFNHTIKMLFSQDYKMLEIVISNLKNANIELIHIESRQVNSKNYSDASMNGLIYNSLEILFVFNCTRRSYKEIIAKLIDEDKNYQKLTEFKIKDEIVDDIWIPKHISDLDNCNHLVLKF 176

HSP 2 Score: 77.0258 bits (188), Expect = 1.110e-15
Identity = 34/36 (94.44%), Postives = 35/36 (97.22%), Query Frame = 1 
Query:  733 FEFQPEMASDHPGFHDKEYQKRRMEIAEIAFNFKHG 840
             +FQPEMASDHPGFHDKEYQKRRMEIAEIAFNFKHG
Sbjct:  174 LKFQPEMASDHPGFHDKEYQKRRMEIAEIAFNFKHG 209
[Close]
BLAST of tyrosine hydroxylase vs. Planmine SMEST
Match: SMESG000077798.1 (SMESG000077798.1)

HSP 1 Score: 41.9726 bits (97), Expect = 1.762e-7
Identity = 17/31 (54.84%), Postives = 24/31 (77.42%), Query Frame = 1 
Query:  748 EMASDHPGFHDKEYQKRRMEIAEIAFNFKHG 840
            E+ +DHPGF D  Y++RR + A+IAF +KHG
Sbjct:  130 ELDADHPGFTDPVYRERRKQFADIAFFYKHG 160

HSP 2 Score: 31.5722 bits (70), Expect = 1.762e-7
Identity = 37/135 (27.41%), Postives = 61/135 (45.19%), Query Frame = 2 
Query:  359 EFPDEEETEKFNHTIKMLFSQDYKMLEIVISNLKNANIELIHIESRQVNSKNYSDASMNGLIYNSLEILFVFNCTRRSYKEIIAKLIDEDKNYQKLT-EFKI----KDEIVDDI-WIPKHISDLDNCNHLVLNFN 745
            +FPD+E     N TI +  S     L  ++   K  ++ L+HIESR   SKN  +       Y+     F+ N   R+       L+   +N Q L+ E ++     D +  D+ W P+ I DLD   + +L++ 
Sbjct:   16 DFPDKEG----NTTILITASSKIGSLASILEIFKKNHVNLLHIESRP--SKNLKEQ------YD-----FLINADNRT-----GGLMMAIENLQGLSLEVQVLSRQHDNLKGDVPWFPRKIKDLDRFANQILSYG 128
The following BLAST results are available for this feature:
BLAST of tyrosine hydroxylase vs. Ensembl Human
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Human e!99)
Total hits: 5
Match NameE-valueIdentityDescription
TH2.011e-954.29tyrosine hydroxylase [Source:HGNC Symbol;Acc:HGNC:... [more]
TH2.065e-954.29tyrosine hydroxylase [Source:HGNC Symbol;Acc:HGNC:... [more]
TH2.081e-954.29tyrosine hydroxylase [Source:HGNC Symbol;Acc:HGNC:... [more]
TH2.164e-954.29tyrosine hydroxylase [Source:HGNC Symbol;Acc:HGNC:... [more]
TPH12.696e-754.84tryptophan hydroxylase 1 [Source:HGNC Symbol;Acc:H... [more]
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BLAST of tyrosine hydroxylase vs. Ensembl Celegans
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99)
Total hits: 2
Match NameE-valueIdentityDescription
tph-13.900e-860.00TryPtophan Hydroxylase [Source:UniProtKB/TrEMBL;A... [more]
tph-15.523e-860.00TryPtophan Hydroxylase [Source:UniProtKB/TrEMBL;A... [more]
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BLAST of tyrosine hydroxylase vs. Ensembl Fly
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99)
Total hits: 5
Match NameE-valueIdentityDescription
ple3.161e-1154.29gene:FBgn0005626 transcript:FBtr0076956[more]
ple7.766e-1154.29gene:FBgn0005626 transcript:FBtr0076957[more]
ple7.766e-1154.29gene:FBgn0005626 transcript:FBtr0345585[more]
Hn6.305e-761.29gene:FBgn0001208 transcript:FBtr0334645[more]
Hn6.305e-761.29gene:FBgn0001208 transcript:FBtr0076811[more]
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BLAST of tyrosine hydroxylase vs. Ensembl Zebrafish
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99)
Total hits: 5
Match NameE-valueIdentityDescription
th29.606e-1257.14tyrosine hydroxylase 2 [Source:ZFIN;Acc:ZDB-GENE-0... [more]
tph28.988e-951.61tryptophan hydroxylase 2 (tryptophan 5-monooxygena... [more]
tph21.594e-851.61tryptophan hydroxylase 2 (tryptophan 5-monooxygena... [more]
tph22.016e-851.61tryptophan hydroxylase 2 (tryptophan 5-monooxygena... [more]
th3.919e-848.57tyrosine hydroxylase [Source:ZFIN;Acc:ZDB-GENE-990... [more]
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BLAST of tyrosine hydroxylase vs. Ensembl Xenopus
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99)
Total hits: 3
Match NameE-valueIdentityDescription
TH2.268e-1057.14tyrosine hydroxylase [Source:NCBI gene;Acc:1004889... [more]
TH2.780e-1057.14tyrosine hydroxylase [Source:NCBI gene;Acc:1004889... [more]
TPH28.053e-741.94tryptophan hydroxylase 2 [Source:NCBI gene;Acc:100... [more]
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BLAST of tyrosine hydroxylase vs. Ensembl Mouse
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99)
Total hits: 5
Match NameE-valueIdentityDescription
Th3.134e-954.29tyrosine hydroxylase [Source:MGI Symbol;Acc:MGI:98... [more]
Th3.752e-954.29tyrosine hydroxylase [Source:MGI Symbol;Acc:MGI:98... [more]
Th4.982e-954.29tyrosine hydroxylase [Source:MGI Symbol;Acc:MGI:98... [more]
Tph11.245e-754.84tryptophan hydroxylase 1 [Source:MGI Symbol;Acc:MG... [more]
Tph11.245e-754.84tryptophan hydroxylase 1 [Source:MGI Symbol;Acc:MG... [more]
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BLAST of tyrosine hydroxylase vs. UniProt/SwissProt
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt)
Total hits: 5
Match NameE-valueIdentityDescription
sp|O17446|TY3H_SCHMA4.871e-1262.86Tyrosine 3-monooxygenase OS=Schistosoma mansoni OX... [more]
sp|P18459|TY3H_DROME5.765e-1054.29Tyrosine 3-monooxygenase OS=Drosophila melanogaste... [more]
sp|Q76IQ3|TY3H_CANLF2.759e-957.14Tyrosine 3-monooxygenase OS=Canis lupus familiaris... [more]
sp|P04177|TY3H_RAT5.919e-957.14Tyrosine 3-monooxygenase OS=Rattus norvegicus OX=1... [more]
sp|O42091|TY3H_ANGAN6.967e-954.29Tyrosine 3-monooxygenase OS=Anguilla anguilla OX=7... [more]
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BLAST of tyrosine hydroxylase vs. TrEMBL
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL)
Total hits: 5
Match NameE-valueIdentityDescription
F6KBQ15.134e-9399.30Tyrosine hydroxylase (Fragment) OS=Schmidtea medit... [more]
A6P4D35.874e-8275.57Tyrosine hydroxylase OS=Dugesia japonica OX=6161 G... [more]
K1QYX82.825e-2430.00Tyrosine 3-monooxygenase OS=Crassostrea gigas OX=2... [more]
A0A1S3HUS16.021e-2026.98phenylalanine-4-hydroxylase OS=Lingula unguis OX=7... [more]
A0A210Q5A71.455e-1729.15Tyrosine 3-monooxygenase OS=Mizuhopecten yessoensi... [more]
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BLAST of tyrosine hydroxylase vs. Ensembl Cavefish
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99)
Total hits: 5
Match NameE-valueIdentityDescription
th23.278e-1257.14tyrosine hydroxylase 2 [Source:ZFIN;Acc:ZDB-GENE-0... [more]
th1.483e-951.43tyrosine hydroxylase [Source:NCBI gene;Acc:1030235... [more]
th1.618e-951.43tyrosine hydroxylase [Source:NCBI gene;Acc:1030235... [more]
th1.744e-951.43tyrosine hydroxylase [Source:NCBI gene;Acc:1030235... [more]
tph1b2.618e-953.33tryptophan 5-hydroxylase 1-like [Source:NCBI gene;... [more]
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BLAST of tyrosine hydroxylase vs. Ensembl Sea Lamprey
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99)
Total hits: 1
Match NameE-valueIdentityDescription
tph1a1.920e-754.84tryptophan hydroxylase 1 (tryptophan 5-monooxygena... [more]
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BLAST of tyrosine hydroxylase vs. Ensembl Yeast
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46)
Total hits: 0
Match NameE-valueIdentityDescription
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BLAST of tyrosine hydroxylase vs. Ensembl Nematostella
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46)
Total hits: 1
Match NameE-valueIdentityDescription
EDO317451.243e-661.29Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7... [more]
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BLAST of tyrosine hydroxylase vs. Ensembl Medaka
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99)
Total hits: 5
Match NameE-valueIdentityDescription
tph27.206e-1025.00tryptophan hydroxylase 2 [Source:NCBI gene;Acc:101... [more]
th21.016e-951.43tyrosine 3-monooxygenase-like [Source:NCBI gene;Ac... [more]
th1.586e-951.43tyrosine hydroxylase [Source:NCBI gene;Acc:1011715... [more]
pah1.550e-747.22phenylalanine hydroxylase [Source:NCBI gene;Acc:10... [more]
tph1b1.688e-751.61tryptophan 5-hydroxylase 1 [Source:NCBI gene;Acc:1... [more]
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BLAST of tyrosine hydroxylase vs. Planmine SMEST
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST)
Total hits: 2
Match NameE-valueIdentityDescription
SMESG000034472.15.019e-12299.43SMESG000034472.1[more]
SMESG000077798.11.762e-754.84SMESG000077798.1[more]
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Cross References
External references for this transcript
DatabaseAccession
SmedGD GBrowseSMED30012000
GenBankAEE89449.1
Sequences
The following sequences are available for this feature:

transcript sequence

>SMED30012000 ID=SMED30012000|Name=tyrosine hydroxylase|organism=Schmidtea mediterranea sexual|type=transcript|length=841bp
GATTATTAAAAAGCTTATATTTCTTTTTTATCAAATAGAGAGTTACATAA
TTAAATTCATGAAACAATTTTTTATTCTACGTTCTGATTCGAAGACAAAT
TTCCAACAAACTGAATATATTTCAGTACCAATCAACCAATCACATTAAGT
GCTACACAACAATACTTACTCCGAATTTGGTTATAAAGTTACTTTTTCAC
TTTTTTTTAGAAAAATGTCATATAATTCAAGAAGACTACAATTCCAAAAG
ACATTTAGTTATGAACACCAGTCAGAATTTCATCGAAGAAGCATAATTGA
AGATGCTAAATTTGACGCTGCTCTCAATTCTGAATTTTCAAATCATTTCA
AAAATAATGAATTTCCAGATGAAGAGGAAACAGAAAAATTTAATCACACT
ATAAAGATGCTATTTAGTCAAGATTACAAAATGCTAGAGATTGTAATAAG
TAATCTTAAGAATGCCAATATTGAATTAATTCACATTGAATCGAGGCAAG
TTAATTCTAAAAATTATTCAGATGCTTCCATGAACGGGCTAATTTATAAC
AGTCTTGAAATACTTTTTGTGTTTAATTGCACTAGAAGGTCTTACAAGGA
AATTATAGCGAAATTAATTGATGAAGATAAAAATTATCAAAAATTAACAG
AATTCAAAATAAAAGATGAAATTGTGGACGATATTTGGATTCCTAAGCAT
ATTTCCGACTTGGATAACTGCAATCACCTGGTTTTGAATTTCAACCAGAA
ATGGCTTCAGACCATCCGGGTTTTCATGATAAAGAATATCAGAAAAGAAG
AATGGAAATAGCGGAAATAGCATTTAATTTTAAGCATGGAG
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protein sequence of SMED30012000-orf-1

>SMED30012000-orf-1 ID=SMED30012000-orf-1|Name=SMED30012000-orf-1|organism=Schmidtea mediterranea sexual|type=polypeptide|length=199bp
MSYNSRRLQFQKTFSYEHQSEFHRRSIIEDAKFDAALNSEFSNHFKNNEF
PDEEETEKFNHTIKMLFSQDYKMLEIVISNLKNANIELIHIESRQVNSKN
YSDASMNGLIYNSLEILFVFNCTRRSYKEIIAKLIDEDKNYQKLTEFKIK
DEIVDDIWIPKHISDLDNCNHLVLNFNQKWLQTIRVFMIKNIRKEEWK*
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Aliases
The feature 'tyrosine hydroxylase' has the following synonyms
Synonym
tyrosine_hydroxylase
Annotated Terms
The following terms have been associated with this transcript:
Vocabulary: Planarian Anatomy
TermDefinition
PLANA:0000044cephalic ganglia
PLANA:0000099neuron
PLANA:0000418head
PLANA:0000482dopaminergic neuron
Vocabulary: INTERPRO
TermDefinition
IPR036951ArAA_hydroxylase_sf
IPR036329Aro-AA_hydroxylase_C_sf
IPR019774Aromatic-AA_hydroxylase_C
IPR001273ArAA_hydroxylase
Vocabulary: molecular function
TermDefinition
GO:0005506iron ion binding
GO:0016714oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced pteridine as one donor, and incorporation of one atom of oxygen
GO:0004497monooxygenase activity
GO:0046872metal ion binding
Vocabulary: biological process
TermDefinition
GO:0055114oxidation-reduction process
GO:0009072aromatic amino acid family metabolic process
InterPro
Analysis Name: Schmidtea mediteranean smed_20140614 Interproscan
Date Performed: 2020-05-01
IPR TermIPR DescriptionSourceSource TermSource DescriptionAlignment
IPR036951Aromatic amino acid hydroxylase superfamilyGENE3DG3DSA:1.10.800.10coord: 46..199
e-value: 5.2E-22
score: 79.9
IPR019774Aromatic amino acid hydroxylase, C-terminalPFAMPF00351Biopterin_Hcoord: 158..199
e-value: 1.1E-12
score: 47.7
IPR019774Aromatic amino acid hydroxylase, C-terminalPROSITEPS51410BH4_AAA_HYDROXYL_2coord: 144..199
score: 18.08
NoneNo IPR availablePANTHERPTHR11473:SF15TYROSINE 3-MONOOXYGENASEcoord: 43..199
IPR001273Aromatic amino acid hydroxylasePANTHERPTHR11473AROMATIC AMINO ACID HYDROXYLASEcoord: 43..199
IPR036329Aromatic amino acid monoxygenase, C-terminal domain superfamilySUPERFAMILYSSF56534Aromatic aminoacid monoxygenases, catalytic and oligomerization domainscoord: 157..197