RUN domain-containing protein

Overview
NameRUN domain-containing protein
Smed IDSMED30011972
Length (bp)1851
Neoblast Clusters

Zeng et. al., 2018



▻ Overview

▻ Neoblast Population

▻ Sub-lethal Irradiated Surviving X1 and X2 Cell Population

 

 

Overview

 

Single cell RNA-seq of pluripotent neoblasts and its early progenies


We isolated X1 neoblasts cells enriched in high piwi-1 expression (Neoblast Population), and profiled ∼7,614 individual cells via scRNA-seq. Unsupervised analyses uncovered 12 distinct classes from 7,088 high-quality cells. We designated these classes Nb1 to Nb12 and ordered them based on high (Nb1) to low (Nb12) piwi-1 expression levels. We further defined groups of genes that best classified the cells parsed into 12 distinct cell clusters to generate a scaled expression heat map of discriminative gene sets for each cluster. Expression of each cluster’s gene signatures was validated using multiplex fluorescence in situ hybridization (FISH) co-stained with piwi-1 and largely confirmed the cell clusters revealed by scRNA-seq.

We also tested sub-lethal irradiation exposure. To profile rare pluripotent stem cells (PSCs) and avoid interference from immediate progenitor cells, we determined a time point after sub-lethal irradiation (7 DPI) with minimal piwi-1+ cells, followed by isolation and single-cell RNA-seq of 1,200 individual cells derived from X1 (Piwi-1 high) and X2 (Piwi-1 low) cell populations (Sub-lethal Irradiated Surviving X1 and X2 Cell Population)



Explore this single cell expression dataset with our NB Cluster Shiny App



 

Neoblast Population

 

t-SNE plot shows two-dimensional representation of global gene expression relationships among all neoblasts (n = 7,088 after filter). Cluster identity was assigned based on the top 10 marker genes of each cluster (Table S2), followed by inspection of RNA in situ hybridization patterns. Neoblast groups, Nb.


Expression of RUN domain-containing protein (SMED30011972) t-SNE clustered cells

Violin plots show distribution of expression levels for RUN domain-containing protein (SMED30011972) in cells (dots) of each of the 12 neoblast clusters.

 

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Sub-lethal Irradiated Surviving X1 and X2 Cell Population

 

t-SNE plot of surviving X1 and X2 cells (n = 1,039 after QC filter) after sub-lethal irradiation. Colors indicate unbiased cell classification via graph-based clustering. SL, sub-lethal irradiated cell groups.

Expression of RUN domain-containing protein (SMED30011972) in the t-SNE clustered sub-lethally irradiated X1 and X2 cells.

Violin plots show distribution of expression levels for RUN domain-containing protein (SMED30011972) in cells (dots) of each of the 10 clusters of sub-leathally irradiated X1 and X2 cells.

 

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Embryonic Expression

Davies et. al., 2017

Hover the mouse over a column in the graph to view average RPKM values per sample.
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Embryonic Stages: Y: yolk. S2-S8: Stages 2-8. C4: asexual adult. SX: virgin, sexually mature adult.
For further information about sample preparation and analysis for the single animal RNA-Seq experiment, please refer to the Materials and Methods

 

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Anatomical Expression

PAGE et. al., 2020



SMED30011972

has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGE



PAGE Curations: 3

  
Expressed InReference TranscriptGene ModelsPublished TranscriptTranscriptomePublicationSpecimenLifecycleEvidence
nervous systemSMED30011972SMESG000055058.1 dd_Smed_v4_9759_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018		FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
cephalic gangliaSMED30011972SMESG000055058.1 dd_Smed_v4_9759_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018		FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
neoblastSMED30011972SMESG000055058.1 dd_Smed_v4_9759_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018		FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
Note: Hover over icons to view figure legend
Homology
[Close]
BLAST of RUN domain-containing protein vs. Ensembl Zebrafish
Match: si:ch211-250n8.1 (si:ch211-250n8.1 [Source:ZFIN;Acc:ZDB-GENE-130603-2])

HSP 1 Score: 124.405 bits (311), Expect = 3.939e-30
Identity = 84/269 (31.23%), Postives = 140/269 (52.04%), Query Frame = 1 
Query:  121 SKEEIVDDNKALENLCEVIEDILRKGLFRVGGLLGLEHRDYWCWFSELPKILKQHENQNPSSFKYKLHHRYGDCLDIVKRYSEKVDTHQGKGRLMIRALIQNKILHWPFECLCLTVKSVSRYYSDFNSLLNNEILAQMLISQLSQLSVLNFKLNLKNAMFLDETWTIPCYATYEFVPCKQLGVNLLAADAYQIVETVKKGSVAEEEKYFQSGDILDELFDSSLKWCKTPLKD-VMKVHEHKPVRLSVVKLRLKDGTLFPPILRLLRKYE 924
            S+  + D N  L + CE++E ILRKGL +   +L L HRDYW  F +L   L+       SS    +                K+ T QG+GR  IR +++ + L    + L L    V  +Y    S+L NE L +  +S    LS ++FK++++N  FLDE+W +P    YE VPC++LG+ L   D    V  + +GS A+ + + + GDI+DE+   SL+         V+   + +P+ +  ++ R +DG+++ P+++ LR+ E
Sbjct:   20 SEGTVTDSNPHLPSCCELLELILRKGLQQ--PVLSLAHRDYWHCFEQL---LQHDTCGRLSSISLAVQQSTA---------CSKLITSQGRGRFFIRLMLRRRTLGSVVKHL-LHTNRVIEWYCPNISILRNEELLEPFLSLSMVLSEMDFKISVENCSFLDESWLLPVCQIYEVVPCRELGIALRYLDGRVFVLDLLQGSQAQVDMFAEPGDIIDEINGISLRNASNGQAGVVLSKLKGQPLSIHFIRWRGEDGSIYQPLVKHLRQLE 273
[Close]
BLAST of RUN domain-containing protein vs. Ensembl Zebrafish
Match: unk (unk zinc finger [Source:ZFIN;Acc:ZDB-GENE-040426-707])

HSP 1 Score: 86.2705 bits (212), Expect = 1.945e-18
Identity = 49/156 (31.41%), Postives = 88/156 (56.41%), Query Frame = 1 
Query:  460 LTVKSVSRYYSDFNSLLNNEILAQMLISQLSQLSVLNFKLNLKNAMFLDETWTIPCYATYEFVPCKQLGVNLLAADAYQIVETVKKGSVAEEEKYFQSGDILDELFDSSLKWCKTPLKD-VMKVHEHKPVRLSVVKLRLKDGTLFPPILRLLRKYE 924
            L    V  +Y    S+L NE L +  +S    LS ++FK++++N  FLDE+W +P    YE VPC++LG+ L   D    V  + +GS A+ + + + GDI+DE+   SL+         V+   + +P+ +  ++ R +DG+++ P+++ LR+ E
Sbjct:   15 LHTNRVIEWYCPNISILRNEELLEPFLSLSMVLSEMDFKISVENCSFLDESWLLPVCQIYEVVPCRELGIALRYLDGRVFVLDLLQGSQAQVDMFAEPGDIIDEINGISLRNASNGQAGVVLSKLKGQPLSIHFIRWRGEDGSIYQPLVKHLRQLE 170
[Close]
BLAST of RUN domain-containing protein vs. Ensembl Xenopus
Match: clrn1 (clarin 1 [Source:Xenbase;Acc:XB-GENE-6044813])

HSP 1 Score: 155.606 bits (392), Expect = 6.797e-41
Identity = 129/468 (27.56%), Postives = 210/468 (44.87%), Query Frame = 1 
Query:  121 SKEEIVDDNKALENLCEVIEDILRKGLFRVGGLLGLEHRDYWCWFSELPKILKQHENQNPSSFKYKLHHRYGDCLDIVKRYSEKVDTHQGKGRLMIRALIQNKILHWPFECLCLTVKSVSRYYSDFNSLLNNEILAQMLISQLSQLSVLNFKLNLKNAMFLDETWTIPCYATYEFVPCKQLGVNLLAADAYQIVETVKKGSVAEEEKYFQSGDILDELFDSSLKWC-KTPLKDVMKVHEHKPVRLSVVKLRLKDGTLFPPILRLLRKYELIHLIEGREMNLSIPISTPLPIHARPNDLFPDDVPAPNPNMSPHYGLRXXXXXXXXXXXXXXKIESSIAETLKHYNDPYSYVPIYIELGEKDVLVRKASITKQVDNVKGSV--DSIDKEMNRTDPQTLPILFAHAYPQISSCGRRVDCSRFLAYIVGESTC-VFSKHFVCHVFEARSEPESKAILCSIAQGFERTHWTI 1512
              E I DD+  +  LC+++E ILRKGL    G+LGL+ RDYW W  E+P    QH+     S    +  + G C         K+ T QG+GR  +R  +  K +    + L L  + +  +Y    S+L NE   +  +S L  +S  +F L+L+N+ FLDE+W +P  A Y+ VPC++LG+ L   +    V  +  GS AE ++    GDILDE+   SL++        V+   + +P+   +++ + KDG L+ P         LI  I+G +                      + VP+    + P             S     + +  +  TL++            + G K+VL    +  ++++     V  D  + E+   D ++  ++F + YP ISS GRRVD  +  A    +  C   +  F C  FE  S  E + I+  IA GF+ T W +
Sbjct:   22 GSEPITDDSPHVTPLCDILEMILRKGL--KSGVLGLKRRDYWDWIEEMP----QHDTCGRLSHLSVMIEKTGAC--------PKLLTAQGRGRYFLRLALNRKYVAATVQHL-LHTRRLLEWYDPLISVLGNEEYLEPFLSMLLVVSQSHFALDLQNSSFLDESWLLPVCALYQTVPCRELGMVLRYHEGRVFVVELLPGSQAEVDEIVLCGDILDEINGVSLRYAYNGQAGTVLNRLKGEPLYFGLIRWQWKDGQLYRP---------LIPYIKGVQ----------------------EKVPSFQLQLQPK---------NQESGQDRPQQDGRLMYTLQYLGKA-----AVGKFGGKEVLDVGITKVRELNCSPKEVLFDVKETEVRIQDKKSHKVMFRYPYPDISSVGRRVDNKKVFALCTADKDCTTTTTSFSCLAFETASNEECEEIIRRIAAGFKHTEWFV 429
[Close]
BLAST of RUN domain-containing protein vs. Ensembl Xenopus
Match: clrn1 (clarin 1 [Source:Xenbase;Acc:XB-GENE-6044813])

HSP 1 Score: 139.813 bits (351), Expect = 1.375e-35
Identity = 119/445 (26.74%), Postives = 195/445 (43.82%), Query Frame = 1 
Query:  190 RKGLFRVGGLLGLEHRDYWCWFSELPKILKQHENQNPSSFKYKLHHRYGDCLDIVKRYSEKVDTHQGKGRLMIRALIQNKILHWPFECLCLTVKSVSRYYSDFNSLLNNEILAQMLISQLSQLSVLNFKLNLKNAMFLDETWTIPCYATYEFVPCKQLGVNLLAADAYQIVETVKKGSVAEEEKYFQSGDILDELFDSSLKWC-KTPLKDVMKVHEHKPVRLSVVKLRLKDGTLFPPILRLLRKYELIHLIEGREMNLSIPISTPLPIHARPNDLFPDDVPAPNPNMSPHYGLRXXXXXXXXXXXXXXKIESSIAETLKHYNDPYSYVPIYIELGEKDVLVRKASITKQVDNVKGSV--DSIDKEMNRTDPQTLPILFAHAYPQISSCGRRVDCSRFLAYIVGESTC-VFSKHFVCHVFEARSEPESKAILCSIAQGFERTHWTI 1512
            R G    GG+LGL+ RDYW W  E+P    QH+     S    +  + G C         K+ T QG+GR  +R  +  K +    + L L  + +  +Y    S+L NE   +  +S L  +S  +F L+L+N+ FLDE+W +P  A Y+ VPC++LG+ L   +    V  +  GS AE ++    GDILDE+   SL++        V+   + +P+   +++ + KDG L+ P         LI  I+G +                      + VP+    + P             S     + +  +  TL++            + G K+VL    +  ++++     V  D  + E+   D ++  ++F + YP ISS GRRVD  +  A    +  C   +  F C  FE  S  E + I+  IA GF+ T W +
Sbjct:    6 RWGGESTGGVLGLKRRDYWDWIEEMP----QHDTCGRLSHLSVMIEKTGAC--------PKLLTAQGRGRYFLRLALNRKYVAATVQHL-LHTRRLLEWYDPLISVLGNEEYLEPFLSMLLVVSQSHFALDLQNSSFLDESWLLPVCALYQTVPCRELGMVLRYHEGRVFVVELLPGSQAEVDEIVLCGDILDEINGVSLRYAYNGQAGTVLNRLKGEPLYFGLIRWQWKDGQLYRP---------LIPYIKGVQ----------------------EKVPSFQLQLQPK---------NQESGQDRPQQDGRLMYTLQYLGKA-----AVGKFGGKEVLDVGITKVRELNCSPKEVLFDVKETEVRIQDKKSHKVMFRYPYPDISSVGRRVDNKKVFALCTADKDCTTTTTSFSCLAFETASNEECEEIIRRIAAGFKHTEWFV 392
[Close]
BLAST of RUN domain-containing protein vs. Ensembl Xenopus
Match: clrn1 (clarin 1 [Source:Xenbase;Acc:XB-GENE-6044813])

HSP 1 Score: 130.183 bits (326), Expect = 2.521e-32
Identity = 85/262 (32.44%), Postives = 137/262 (52.29%), Query Frame = 1 
Query:  121 SKEEIVDDNKALENLCEVIEDILRKGLFRVGGLLGLEHRDYWCWFSELPKILKQHENQNPSSFKYKLHHRYGDCLDIVKRYSEKVDTHQGKGRLMIRALIQNKILHWPFECLCLTVKSVSRYYSDFNSLLNNEILAQMLISQLSQLSVLNFKLNLKNAMFLDETWTIPCYATYEFVPCKQLGVNLLAADAYQIVETVKKGSVAEEEKYFQSGDILDELFDSSLKWC-KTPLKDVMKVHEHKPVRLSVVKLRLKDGTLFPPIL 903
              E I DD+  +  LC+++E ILRKGL    G+LGL+ RDYW W  E+P    QH+     S    +  + G C         K+ T QG+GR  +R  +  K +    + L L  + +  +Y    S+L NE   +  +S L  +S  +F L+L+N+ FLDE+W +P  A Y+ VPC++LG+ L   +    V  +  GS AE ++    GDILDE+   SL++        V+   + +P+   +++ + KDG L+ P++
Sbjct:   22 GSEPITDDSPHVTPLCDILEMILRKGL--KSGVLGLKRRDYWDWIEEMP----QHDTCGRLSHLSVMIEKTGAC--------PKLLTAQGRGRYFLRLALNRKYVAATVQHL-LHTRRLLEWYDPLISVLGNEEYLEPFLSMLLVVSQSHFALDLQNSSFLDESWLLPVCALYQTVPCRELGMVLRYHEGRVFVVELLPGSQAEVDEIVLCGDILDEINGVSLRYAYNGQAGTVLNRLKGEPLYFGLIRWQWKDGQLYRPLI 268
[Close]
BLAST of RUN domain-containing protein vs. TrEMBL
Match: A0A267FU63 (Uncharacterized protein OS=Macrostomum lignano OX=282301 GN=BOX15_Mlig008272g3 PE=4 SV=1)

HSP 1 Score: 319.316 bits (817), Expect = 1.416e-98
Identity = 195/497 (39.24%), Postives = 274/497 (55.13%), Query Frame = 1 
Query:  124 KEEIVDDNKALENLCEVIEDILRKGLFRVGGLLGLEHRDYWCWFSELPKI-----------LKQHENQNPSSFKYKLHHRYGDCLDIVKRYSE-KVDTHQGKGRLMIRALIQNKILHWPFECLCLTVKSVSRYYSDFNSLLNNEILAQMLISQLSQLSVLNFKLNLKNAMFLDETWTIPCYATYEFVPCKQLGVNLLAADAYQIVETVKKGSVAEEEKYFQSGDILDELFDSSLKWCKTPLKDVMKVHEHKPVRLSVVKLRLKDGTLFPPILRLLRKYELIHLIEGRE--------------MNLSIPI--------STPLPIHARPNDLFPDDVPAPNPNMSPHYGLRXXXXXXXXXXXXXXKIESSIAETLKHYNDPYSYVPIYIELGEKDVLVRKASITKQVDNVKGSVDSIDKEMNRTDPQTLPILFAHAYPQISSCGRRVDCSRFLAYIVGESTCVFSKHFVCHVFEARSEPESKAILCSIAQGFERTHWTI 1512
            + +I D + +LE LC  +E+IL KGL +  GL    HRD + W   LP +            +Q      S      H   G    I    SE +V    G+GRL++R L+Q +++HWP   LC  ++  + +Y D  S++ N+ILA++L S L +LS   F LNL+NA FLD +W++P Y  YEFVPC +LG++L+    +Q+VETV  GSVA E+   + GDILDEL    +K+    ++ ++K ++  PV    +K RL D +L+ P+L LL+      L+                  +N   P+        S  +PIHAR ++   DD+PA NP+M+P Y +RYVG+  +GS GGVS IE  I   L  + DP  Y P  +EL EK+VL                           D QT  +L  HAYPQI+SCGRR+DC RF+AY+ GE+TC  ++ F CHVFEARS+ ES+ ILCSIAQGFERTHW +
Sbjct:   25 QADIPDSHPSLEPLCSTLEEILAKGLRQSAGLFS-GHRDCYHWMFLLPDLCSRRPPGVTLDFQQVPGAGGSDSLGGGHLHPGVEAAIQAAKSEPRVREPLGRGRLLVRCLLQRRLIHWPVLTLCRVLRQAADFYDDLYSIVGNDILAEILASLLLELSKAKFALNLRNAAFLDCSWSLPRYCYYEFVPCSKLGLHLVCMQGHQVVETVLPGSVAAEDAKIEPGDILDELLGQCIKFNGARIRKMIKDNQGWPVPTWFIKARLPDASLYQPLLHLLKSAGQAGLLNHVRRHPDAPRAPRGIPGVNFDDPLAEDGAAGQSQLMPIHARLDEDASDDIPAANPDMAPTYSVRYVGNLSMGSNGGVSSIEPGIERVLAAFPDPAVYRPCQLELDEKEVLA-------------------------IDCQTGEVLVRHAYPQIASCGRRLDCVRFVAYMGGETTCTIARDFRCHVFEARSDYESRTILCSIAQGFERTHWAL 495
[Close]
BLAST of RUN domain-containing protein vs. TrEMBL
Match: A0A267GR49 (Uncharacterized protein OS=Macrostomum lignano OX=282301 GN=BOX15_Mlig008272g1 PE=4 SV=1)

HSP 1 Score: 318.161 bits (814), Expect = 4.540e-98
Identity = 194/497 (39.03%), Postives = 273/497 (54.93%), Query Frame = 1 
Query:  124 KEEIVDDNKALENLCEVIEDILRKGLFRVGGLLGLEHRDYWCWFSELPKI-----------LKQHENQNPSSFKYKLHHRYGDCLDIVKRYSE-KVDTHQGKGRLMIRALIQNKILHWPFECLCLTVKSVSRYYSDFNSLLNNEILAQMLISQLSQLSVLNFKLNLKNAMFLDETWTIPCYATYEFVPCKQLGVNLLAADAYQIVETVKKGSVAEEEKYFQSGDILDELFDSSLKWCKTPLKDVMKVHEHKPVRLSVVKLRLKDGTLFPPILRLLRKYELIHLIEGRE--------------MNLSIPI--------STPLPIHARPNDLFPDDVPAPNPNMSPHYGLRXXXXXXXXXXXXXXKIESSIAETLKHYNDPYSYVPIYIELGEKDVLVRKASITKQVDNVKGSVDSIDKEMNRTDPQTLPILFAHAYPQISSCGRRVDCSRFLAYIVGESTCVFSKHFVCHVFEARSEPESKAILCSIAQGFERTHWTI 1512
            + +I D + +LE LC  +E+IL KGL +  GL    HRD + W   LP +            +Q      S      H   G    I    SE +V    G+GRL++R L+Q +++HWP   LC  ++  + +Y D  S++ N+ILA++L S L +LS   F LNL+NA FLD +W++P Y  YEFVPC +LG++L+    +Q+VE V  GSVA E+   + GDILDEL    +K+    ++ ++K ++  PV    +K RL D +L+ P+L LL+      L+                  +N   P+        S  +PIHAR ++   DD+PA NP+M+P Y +RYVG+  +GS GGVS IE  I   L  + DP  Y P  +EL EK+VL                           D QT  +L  HAYPQI+SCGRR+DC RF+AY+ GE+TC  ++ F CHVFEARS+ ES+ ILCSIAQGFERTHW +
Sbjct:   25 QADIPDSHPSLEPLCSTLEEILAKGLRQSAGLFS-GHRDCYHWMFLLPDLCSRRPPGVTLDFQQVPGAGGSDSLGGGHLHPGVEAAIQAAKSEPRVREPLGRGRLLVRCLLQRRLIHWPVLTLCRVLRQAAEFYDDLYSIVGNDILAEILASLLLELSKAKFTLNLRNAAFLDCSWSLPRYCYYEFVPCSKLGLHLVCMQGHQVVEAVLPGSVAAEDAKIEPGDILDELLGQCIKFNGARIRKMIKDNQGWPVPTWFIKARLPDASLYQPLLHLLKSAGQAGLLNHVRRHPDAPRAPRGIPGVNFDDPLAEDGAAGQSQLMPIHARLDEDASDDIPAANPDMAPTYSVRYVGNLSMGSNGGVSSIEPGIERVLAAFPDPAVYRPCRLELDEKEVLA-------------------------IDCQTGEVLVRHAYPQIASCGRRLDCVRFVAYMGGETTCTIARDFRCHVFEARSDYESRTILCSIAQGFERTHWAL 495
[Close]
BLAST of RUN domain-containing protein vs. TrEMBL
Match: R7V7C3 (Uncharacterized protein OS=Capitella teleta OX=283909 GN=CAPTEDRAFT_199812 PE=4 SV=1)

HSP 1 Score: 265.388 bits (677), Expect = 2.099e-78
Identity = 166/469 (35.39%), Postives = 250/469 (53.30%), Query Frame = 1 
Query:  133 IVDDNKALENLCEVIEDILRKGLFRVGGLLGLEHRDYWCWFSELPKILKQHENQNPSSFKYKLHHRYGDCLDIVKRYSEKVDTHQGKGRLMIRALIQNKILHWPFECLCLTVKSVSRYYSDFNSLLNNEILAQMLISQLSQLSVLNFKLNLKNAMFLDETWTIPCYATYEFVPCKQLGVNLLAADAYQIVETVKKGSVAEEEKYFQSGDILDELFDSSLK-WCKTPLKDVMKVHEHKPVRLSVVKLRLKDGTLFPPILRLLRK----YELIHLIEGREMNLSIPISTPLPIHAR-PNDLFPDDVPAPNPNMSPHYGLRXXXXXXXXXXXXXXKIESSI---AETLKHYNDPYSYVPIYIELGEKDVLVRKASITKQVDNVKGSVDSIDKEMNRTDPQTLPILFAHAYPQISSCGRRVDCSRFLAYIVGESTCVFSKHFVCHVFEARSEPESKAILCSIAQGFERTHWTI 1512
            I D++  L + C+ +E ILRKG+     LLG   RDYW W   L  +  +HE    +     L     DC         KV T QG+GRL +R  +Q KI+  P E L       +  Y   NS+L NEIL ++L+S L +++ +NF+L  K   FLDETW IP Y   E VPC  LG+ +   +   IV ++  G VA E++  + GDILDE+    L+   K  +  +++ ++  PV LSVVK +L DG++FP IL LLR     + ++  +  ++    + +S  +P+HA+ P D+  D++P  + +    Y L+Y+    +G  GGV +IE +I    E +K   +P     ++ E  E DV++      K +D+ K                   ++F H+Y  ISSCGRR D   + AYI GE+TC  ++ FV +VF++ +E E+K ILCSIAQGF RTHW +
Sbjct:   20 ICDEHPHLRSFCQTLELILRKGIRGHASLLGFTKRDYWHWIERLACV--RHEGARINPLFDILVKAVKDC--------RKVITAQGRGRLFLRLSLQRKIMSVPIELLARDPLMATNCYDPTNSILGNEILREILLSLLYEVTAINFRLVTKCMAFLDETWHIPVYKELELVPCSDLGIEVHHVNGRIIVASLDDGGVASEDEKIEPGDILDEILHEPLRNIVKGKIPRILRQNQGFPVYLSVVKCKLSDGSIFPAILSLLRSAGPTFPVLQRVLQQDQERQVALSQKMPLHAQLPEDMV-DEIPVHSEDGRAQYQLKYIAKIIIGQDGGVHQIEGAIKRVMELVKPEENPQEVKSVHFETSETDVII------KDIDSDK-------------------VIFTHSYTTISSCGRRTDNLLYFAYIAGETTCTIAQKFVAYVFKSNTEIEAKTILCSIAQGFGRTHWFV 452
[Close]
BLAST of RUN domain-containing protein vs. TrEMBL
Match: A0A1S3K0T3 (uncharacterized protein LOC106177605 OS=Lingula unguis OX=7574 GN=LOC106177605 PE=4 SV=1)

HSP 1 Score: 259.225 bits (661), Expect = 1.053e-75
Identity = 175/490 (35.71%), Postives = 259/490 (52.86%), Query Frame = 1 
Query:  133 IVDDNKALENLCEVIEDILRKGLFRVGGLLGLEHRDYWCWFSELPKILKQHENQNPSSFKYKLHHRYGDCLDIVKRYSEKVDTHQGKGRLMIRALIQNKILHWPFECLCLTVKSVSRYYSDFNSLLNNEILAQMLISQLSQLSVLNFKLNLKNAMFLDETWTIPC-----------------------YATYEFVPCKQLGVNLLAADAYQIVETVKKGSVAEEEKYFQSGDILDELFDSSLKWCKTP-LKDVMKVHEHKPVRLSVVKLRLKDGTLFPPILRLLRKYE-----LIHLIE-GREMNLSIPISTPLPIHARPNDLFPDDVPAPNPNMSPHYGLRXXXXXXXXXXXXXXKIESSIAETLKHYNDPYSYVPIYIELGEKDVLVRKASITKQVDNVKGSVDSIDKEMNRTDPQTLPILFAHAYPQISSCGRRVDCSRFLAYIVGESTCVFSKHFVCHVFEARSEPESKAILCSIAQGFERTHWTI 1512
            + D+N  L+ LCE IE+ILRKGL +  G+  L  +DYW W   LP       N N      +++  +   ++ V R S+K+ T QG+GRL IR+ +Q K+L  P E +    K + ++Y    S+L+NEIL+++L+S L + + + F LN +N+ FLDETW I                         Y  YEFVPC  LGV++        V  V + SVA E    Q GDILDEL+  +LK  K   +  +++ ++  P+ LSV+K + KDG LFPPI  +LR  +     L  +I+  RE    + ++   P    P D +  DVP   P     Y ++YVG T+VG  G + +IE+++A  L +  D   Y  + +ELGE +V+               ++   ++E  R           HAYP ISSCGRR D S++  YI GE+TC  SK F+C+VF+A  + E++ +LC IAQGF RTHW +
Sbjct:   25 VEDENTYLKPLCETIEEILRKGL-KTSGMFRLSKKDYWHWIDSLPN------NSN-----IRVNPIFSMAVEYV-RSSKKLKTAQGRGRLFIRSALQKKVLSVPLEQILKNQKLLEQWYDPTESILHNEILSEILMSLLFEATEIQFDLNTRNSSFLDETWYISWRREYKFVLMRIDVTKMYLLFLQRYRDYEFVPCDNLGVHVNYISNRAFVIAVDENSVASEYHRIQPGDILDELYGEALKGVKQGRIPSLLRQNKGWPITLSVIKCKYKDGRLFPPIAEMLRCMDTDLPSLSSIIKHARENKDKVDLNKKPPHAVLPEDGY-KDVPIQTPESRARYRVQYVGKTHVGQDGSMCQIENAVATVLSNNPDHRFYQDVDVELGETEVIT--------------TIVETNQEKLR-----------HAYPLISSCGRREDSSQYFGYIAGETTCTMSKDFICYVFKANCDNEARILLCGIAQGFGRTHWFV 475
[Close]
BLAST of RUN domain-containing protein vs. TrEMBL
Match: C3XR80 (Uncharacterized protein OS=Branchiostoma floridae OX=7739 GN=BRAFLDRAFT_120280 PE=4 SV=1)

HSP 1 Score: 251.521 bits (641), Expect = 5.387e-73
Identity = 159/457 (34.79%), Postives = 241/457 (52.74%), Query Frame = 1 
Query:  154 LENLCEVIEDILRKGLFRVGGLLGLEHRDYWCWFSELPKILKQHENQNPSSFKYKLHHRYGDCLDIVKRYSEKVDTHQGKGRLMIRALIQNKILHWPFECLCLTVKSVSRYYSDFNSLLNNEILAQMLISQLSQLSVLNFKLNLKNAMFLDETWTIPCYATYEFVPCKQLGVNLLAADAYQIVETVKKGSVAEEEKYFQSGDILDELFDSSLKWCKT-PLKDVMKVHEHKPVRLSVVKLRLKDGTLFPPILRLLRKY-ELIHLIEGREMNLSIPISTPLPIHARPNDLFPDDVPAPNPNMSPHYGLRXXXXXXXXXXXXXXKIESSIAETLKHYNDPY--SYVPIYIELGEKDVLVRKASITKQVDNVKGSVDSIDKEMNRTDPQTLPILFAHAYPQISSCGRRVDCSRFLAYIVGESTCVFSKHFVCHVFEARSEPESKAILCSIAQGFERTHWTI 1512
            L+ LCE +E ILRKGL + G L G+  RDYW W    P  +  ++  NP              +D+ K  S K+ T QG+GR  IR  +  KI+  P E L    +    +Y    S++ N  L + L++ L  L+ +NF+L++KNA FLDE+W IP Y   E VPC  LG+ +   D    V  V++  VA E+   + GDI+DEL+  SL  CK   +  +++ H+  PV +SV+K RL DGT++PP++  ++K  E +   E +++N   P   P+P HA     +P+  P  +P     +  +YVG    G YG V++IE ++ + ++            +++EL E +V++                         TD +T   L  H+Y +ISSCGRR D +++ A+I G++ C  S++F   VFEA S  ESK ILCSIAQGF RT W +
Sbjct:   46 LKPLCETLERILRKGLKQPGSLFGINKRDYWSWMESTPNYV-CNDKYNPF---------LNRAIDLTKS-SPKLRTLQGRGRCFIRLALAKKIVSVPVEHLLRNARLTEYWYDSGLSIIANPPLGEALMALLFALTDINFELDIKNASFLDESWVIPVYKRLELVPCTSLGMTIRYLDNRIFVVKVEENGVAGEDNKIEPGDIVDELYQESLYGCKQGKVNSLLREHQGWPVYVSVIKCRLPDGTIYPPLVSRIKKLKEELKEFEVKKLNKKGP--APMPAHALLPQDYPEQAPVHDPEGKAEFNAKYVGQVSTGRYGDVAEIEGAVEKAIEQNKQQQITENKEVHVELTETEVII-------------------------TDLKTNKELSKHSYTEISSCGRRSDMTKYFAFIAGDTQCSVSRNFTAFVFEAESADESKIILCSIAQGFGRTSWFV 464
[Close]
BLAST of RUN domain-containing protein vs. Ensembl Cavefish
Match: si:ch211-250n8.1 (uncharacterized LOC111191497 [Source:NCBI gene;Acc:111191497])

HSP 1 Score: 121.709 bits (304), Expect = 2.225e-29
Identity = 83/268 (30.97%), Postives = 138/268 (51.49%), Query Frame = 1 
Query:  121 SKEEIVDDNKALENLCEVIEDILRKGLFRVGGLLGLEHRDYWCWFSELPKILKQHENQNPSSFKYKLHHRYGDCLDIVKRYSE--KVDTHQGKGRLMIRALIQNKILHWPFECLCLTVKSVSRYYSDFNSLLNNEILAQMLISQLSQLSVLNFKLNLKNAMFLDETWTIPCYATYEFVPCKQLGVNLLAADAYQIVETVKKGSVAEEEKYFQSGDILDELFDSSLK-WCKTPLKDVMKVHEHKPVRLSVVKLRLKDGTLFPPILRLLR 915
            ++  + D +  L + CE++E ILR GL +   +L L  RDYW  F +L               +Y    R       V++ +   K+ T QG+GR  IR ++  + L    + L L    V  +Y+   S+L NE   +  +S    LS + FKLNL+N  FLDE+W +P   TYE VPC++LG+ L        V  V +G VA+ +K+ + GDI+DE+  +SL+         ++   + +P+ L +++ R +DG+++ P++  LR
Sbjct:   20 AEGSVTDSSAQLSSCCELLELILRSGLQQP--VLSLSQRDYWHCFEQL--------------LQYDTCGRLSAVSLAVQQTAACPKLLTAQGRGRYFIRLMLTRRTLGNVVKHL-LHTDRVMEFYTPDVSVLRNEEFVEPFLSLCLILSEMEFKLNLQNCSFLDESWLLPVCETYEAVPCRELGMVLRYLGGRVFVLEVLQGGVAQVDKFAEPGDIIDEINGTSLRNSSNGQAGSLLSRLKGQPLTLRLLRWRCEDGSVYRPLVPFLR 270
[Close]
BLAST of RUN domain-containing protein vs. Ensembl Sea Lamprey
Match: fyco1a (FYVE and coiled-coil domain containing 1a [Source:ZFIN;Acc:ZDB-GENE-110411-276])

HSP 1 Score: 47.7506 bits (112), Expect = 8.626e-6
Identity = 52/170 (30.59%), Postives = 80/170 (47.06%), Query Frame = 1 
Query:  133 IVDDNKALENLCEVIEDILRKGLFRVGGLLGLEHRDYWCWFSELPKILKQHENQNPSSFKYKLHHRYGDCLDIVKRYSEKVDTHQGKGRLMIRALIQNKILHWPFECLCLTVKSV-SRYYSDFNSLLNNEILAQMLISQLSQLSVLNFKLNLKNAMFLDETWTIPCYATY 639
            + DDN +L  LC  +E +L+ G      L+G+  R+YW +F +    L + +  N             D +  V   SE + T  GKGR  IR  + ++ L    +  C T K V S +YS  + L+  E++ +M IS L +L+ L F L  +    LD  W  P YA +
Sbjct:   35 VTDDNASLNKLCTKLEYMLQFGQKEKRTLMGI-RREYWDYFHD---CLAKQKGAN-------------DGIRFVNSVSE-LKTAIGKGRAFIRYSLVHQRLADTLQ-QCFTNKPVTSDWYSTKSPLVKKELVTEM-ISHLYELNQLPFDLAPR-GYDLDAEW--PSYARH 181
[Close]
BLAST of RUN domain-containing protein vs. Ensembl Sea Lamprey
Match: fyco1a (FYVE and coiled-coil domain containing 1a [Source:ZFIN;Acc:ZDB-GENE-110411-276])

HSP 1 Score: 47.7506 bits (112), Expect = 9.375e-6
Identity = 52/170 (30.59%), Postives = 80/170 (47.06%), Query Frame = 1 
Query:  133 IVDDNKALENLCEVIEDILRKGLFRVGGLLGLEHRDYWCWFSELPKILKQHENQNPSSFKYKLHHRYGDCLDIVKRYSEKVDTHQGKGRLMIRALIQNKILHWPFECLCLTVKSV-SRYYSDFNSLLNNEILAQMLISQLSQLSVLNFKLNLKNAMFLDETWTIPCYATY 639
            + DDN +L  LC  +E +L+ G      L+G+  R+YW +F +    L + +  N             D +  V   SE + T  GKGR  IR  + ++ L    +  C T K V S +YS  + L+  E++ +M IS L +L+ L F L  +    LD  W  P YA +
Sbjct:   35 VTDDNASLNKLCTKLEYMLQFGQKEKRTLMGI-RREYWDYFHD---CLAKQKGAN-------------DGIRFVNSVSE-LKTAIGKGRAFIRYSLVHQRLADTLQ-QCFTNKPVTSDWYSTKSPLVKKELVTEM-ISHLYELNQLPFDLAPR-GYDLDAEW--PSYARH 181
[Close]
BLAST of RUN domain-containing protein vs. Ensembl Nematostella
Match: EDO47923 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7RKK5])

HSP 1 Score: 147.517 bits (371), Expect = 1.325e-38
Identity = 138/466 (29.61%), Postives = 208/466 (44.64%), Query Frame = 1 
Query:  124 KEEIVDDNKALENLCEVIEDILRKGLFRVGGLLGLEHRDYWCWFSELPKILKQHENQNPSSFKYKLHHRYGDCLDIVKRYSEKVDTHQGKGRLMIRALIQNKILHWPFECLCLTVKSVSRYYSDFNSLLNNEILAQMLISQLSQLSVLNFKLNLKNAMFLDETWTIPCYATYEFVPCKQLGVNLLAADAYQIVETVKKGSVAEEEKYFQSGDILDELFDSSLKWCKTPLKDVMKVHEHKPVRLSVVKLRLKDGTLFPPILRLLRKYELIHLIEGREMNLSIPISTPLPIHARPNDLFP------DDVPAPNPNMSPHYGLRXXXXXXXXXXXXXXKIESSIAETLKHYNDPYSYVPIYIELGEKDVLVRKASITKQVDNVKGSVDSIDKEMNRTDPQTLPILFAHAYPQISSCGRRVDCSRFLAYIVGESTCVFSKHFVCHVFEARSEPESK---AILCSIAQGFE 1494
            K+ I DD+  L  +CE IE++LR GL R     GL   DYWCW   LP+ +     QN       LH           + S+K+  +QG GRL IR  +  ++L    E L    K + +Y+ +  ++L +++ + M    LS L   NF LNLKNA FLDE+W IP     + VPCK+LG+ +   D   IV  VK    A +    + GDI+ EL   SL               HK   L+  K  +K G +FPP                    L++  + P       +D+ P      D+ P    +    Y   + G   VG+ G V+ IE SI E L     P           + ++L+ + +IT         VD I          T  +L  H++ + SSCGRR D    +A++ GE+TC  ++ F C+VF+ + +PE +   A+L   ++G +
Sbjct:   25 KQPIQDDHVFLAPICEGIENVLRVGLKRSVLGFGLVKWDYWCWIESLPRYI-----QNDRRTLALLHGI------TFTKSSKKIVGYQGYGRLFIRFALSKRLLGHVVEGLQKN-KKLLKYWYNETAILCDKVFSDMFRHILSDLEEHNFNLNLKNAYFLDESWVIPELKETQIVPCKELGLVVRHVDNRVIVAHVKSTGAAGDAG-IEYGDIMVELLGKSL---------------HK---LNNGKANMKRGDIFPP----------------SAARLAVIQADPYKEKNPDDDVAPQQLAGWDETPVHASDTLAAYPAVFYGKLDVGTDGSVAVIEDSIIEVLNKAMPPR----------DVELLLSEINIT--------VVDKI----------TSKVLSVHSFTETSSCGRRNDRKDLIAFVSGETTCSLAQRFYCYVFQIK-DPEVRTGFAVLSGSSRGLK 414
[Close]
BLAST of RUN domain-containing protein vs. Planmine SMEST
Match: SMESG000055058.1 (SMESG000055058.1)

HSP 1 Score: 946.036 bits (2444), Expect = 0.000e+0
Identity = 472/475 (99.37%), Postives = 473/475 (99.58%), Query Frame = 1 
Query:   88 CVVGSNDNIIISKEEIVDDNKALENLCEVIEDILRKGLFRVGGLLGLEHRDYWCWFSELPKILKQHENQNPSSFKYKLHHRYGDCLDIVKRYSEKVDTHQGKGRLMIRALIQNKILHWPFECLCLTVKSVSRYYSDFNSLLNNEILAQMLISQLSQLSVLNFKLNLKNAMFLDETWTIPCYATYEFVPCKQLGVNLLAADAYQIVETVKKGSVAEEEKYFQSGDILDELFDSSLKWCKTPLKDVMKVHEHKPVRLSVVKLRLKDGTLFPPILRLLRKYELIHLIEGREMNLSIPISTPLPIHARPNDLFPDDVPAPNPNMSPHYGLRXXXXXXXXXXXXXXKIESSIAETLKHYNDPYSYVPIYIELGEKDVLVRKASITKQVDNVKGSVDSIDKEMNRTDPQTLPILFAHAYPQISSCGRRVDCSRFLAYIVGESTCVFSKHFVCHVFEARSEPESKAILCSIAQGFERTHWTI 1512
            CVVGSNDNIIISKEEIVDDNKALENLCEVIEDILRKGLFRVGGLLGLEHRDYWCWFSELPKILKQHENQN SSFKYKLHHRYGDCLDIVKRYSEKVDTHQGKGRLMIRALIQNKILHWPFECLCLTVKSVSRYYSDFNSLLNNEILAQMLISQLSQLSVLNFKLNLKNAMFLDETWTIPCYATYEFVPCKQLGVNLLAADAYQIVETVKKGSVAEEEKYFQSGDILDELFDSSLKWCKTPLKDVMK HEHKPVRLSVVKLRLKDGTLFPPI+RLLRKYELIHLIEGREMNLSIPISTPLPIHARPNDLFPDDVPAPNPNMSPHYGLRYVGSTYVGSYGGVSKIESSIAETLKHYNDPYSYVPIYIELGEKDVLVRKASITKQVDNVKGSVDSIDKEMNRTDPQTLPILFAHAYPQISSCGRRVDCSRFLAYIVGESTCVFSKHFVCHVFEARSEPESKAILCSIAQGFERTHWTI
Sbjct:   17 CVVGSNDNIIISKEEIVDDNKALENLCEVIEDILRKGLFRVGGLLGLEHRDYWCWFSELPKILKQHENQNSSSFKYKLHHRYGDCLDIVKRYSEKVDTHQGKGRLMIRALIQNKILHWPFECLCLTVKSVSRYYSDFNSLLNNEILAQMLISQLSQLSVLNFKLNLKNAMFLDETWTIPCYATYEFVPCKQLGVNLLAADAYQIVETVKKGSVAEEEKYFQSGDILDELFDSSLKWCKTPLKDVMKAHEHKPVRLSVVKLRLKDGTLFPPIIRLLRKYELIHLIEGREMNLSIPISTPLPIHARPNDLFPDDVPAPNPNMSPHYGLRYVGSTYVGSYGGVSKIESSIAETLKHYNDPYSYVPIYIELGEKDVLVRKASITKQVDNVKGSVDSIDKEMNRTDPQTLPILFAHAYPQISSCGRRVDCSRFLAYIVGESTCVFSKHFVCHVFEARSEPESKAILCSIAQGFERTHWTI 491
The following BLAST results are available for this feature:
BLAST of RUN domain-containing protein vs. Ensembl Human
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Human e!99)
Total hits: 0
Match NameE-valueIdentityDescription
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BLAST of RUN domain-containing protein vs. Ensembl Celegans
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99)
Total hits: 0
Match NameE-valueIdentityDescription
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BLAST of RUN domain-containing protein vs. Ensembl Fly
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99)
Total hits: 0
Match NameE-valueIdentityDescription
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BLAST of RUN domain-containing protein vs. Ensembl Zebrafish
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99)
Total hits: 2
Match NameE-valueIdentityDescription
si:ch211-250n8.13.939e-3031.23si:ch211-250n8.1 [Source:ZFIN;Acc:ZDB-GENE-130603-... [more]
unk1.945e-1831.41unk zinc finger [Source:ZFIN;Acc:ZDB-GENE-040426-7... [more]
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BLAST of RUN domain-containing protein vs. Ensembl Xenopus
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99)
Total hits: 3
Match NameE-valueIdentityDescription
clrn16.797e-4127.56clarin 1 [Source:Xenbase;Acc:XB-GENE-6044813][more]
clrn11.375e-3526.74clarin 1 [Source:Xenbase;Acc:XB-GENE-6044813][more]
clrn12.521e-3232.44clarin 1 [Source:Xenbase;Acc:XB-GENE-6044813][more]
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BLAST of RUN domain-containing protein vs. Ensembl Mouse
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99)
Total hits: 0
Match NameE-valueIdentityDescription
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BLAST of RUN domain-containing protein vs. UniProt/SwissProt
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt)
Total hits: 0
Match NameE-valueIdentityDescription
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BLAST of RUN domain-containing protein vs. TrEMBL
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL)
Total hits: 5
Match NameE-valueIdentityDescription
A0A267FU631.416e-9839.24Uncharacterized protein OS=Macrostomum lignano OX=... [more]
A0A267GR494.540e-9839.03Uncharacterized protein OS=Macrostomum lignano OX=... [more]
R7V7C32.099e-7835.39Uncharacterized protein OS=Capitella teleta OX=283... [more]
A0A1S3K0T31.053e-7535.71uncharacterized protein LOC106177605 OS=Lingula un... [more]
C3XR805.387e-7334.79Uncharacterized protein OS=Branchiostoma floridae ... [more]
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BLAST of RUN domain-containing protein vs. Ensembl Cavefish
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99)
Total hits: 1
Match NameE-valueIdentityDescription
si:ch211-250n8.12.225e-2930.97uncharacterized LOC111191497 [Source:NCBI gene;Acc... [more]
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BLAST of RUN domain-containing protein vs. Ensembl Sea Lamprey
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99)
Total hits: 2
Match NameE-valueIdentityDescription
fyco1a8.626e-630.59FYVE and coiled-coil domain containing 1a [Source:... [more]
fyco1a9.375e-630.59FYVE and coiled-coil domain containing 1a [Source:... [more]
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BLAST of RUN domain-containing protein vs. Ensembl Yeast
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46)
Total hits: 0
Match NameE-valueIdentityDescription
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BLAST of RUN domain-containing protein vs. Ensembl Nematostella
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46)
Total hits: 1
Match NameE-valueIdentityDescription
EDO479231.325e-3829.61Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7... [more]
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BLAST of RUN domain-containing protein vs. Ensembl Medaka
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99)
Total hits: 0
Match NameE-valueIdentityDescription
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BLAST of RUN domain-containing protein vs. Planmine SMEST
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST)
Total hits: 1
Match NameE-valueIdentityDescription
SMESG000055058.10.000e+099.37SMESG000055058.1[more]
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Sequences
The following sequences are available for this feature:

transcript sequence

>SMED30011972 ID=SMED30011972|Name=RUN domain-containing protein|organism=Schmidtea mediterranea sexual|type=transcript|length=1851bp
ATCTATATAAATCTTATATGCATTATTTTTTAAATGTCTATGTCAGATCC
TTTATTAAAATCCTTAAAGAAGTTAATAATTGATTTATGTGTTGTTGGTT
CAAATGATAATATTATCATAAGTAAAGAAGAAATAGTAGATGACAATAAA
GCGTTGGAAAATTTGTGTGAAGTAATAGAAGATATTCTTCGCAAAGGGCT
ATTTAGGGTTGGTGGACTTTTAGGTCTCGAACATCGTGACTATTGGTGTT
GGTTTTCTGAGCTTCCAAAAATTTTAAAACAACATGAAAATCAAAATCCT
TCGAGCTTCAAATATAAATTACATCATCGATATGGGGATTGTTTAGATAT
TGTAAAAAGATATAGTGAAAAAGTAGATACACATCAAGGTAAAGGCAGAT
TAATGATAAGAGCTTTAATTCAAAACAAAATACTACACTGGCCGTTCGAA
TGCCTTTGCTTAACAGTAAAAAGTGTTTCTCGGTACTATTCTGATTTTAA
TTCACTGTTGAACAATGAAATTCTGGCACAAATGCTTATTTCACAGTTGT
CTCAATTGTCAGTCTTGAATTTTAAATTAAACTTAAAAAATGCAATGTTC
CTTGATGAAACTTGGACTATTCCATGTTATGCAACTTATGAGTTCGTACC
ATGCAAGCAATTAGGAGTGAATTTATTAGCCGCTGATGCATATCAAATAG
TTGAAACGGTAAAAAAAGGCAGTGTTGCAGAAGAAGAGAAATATTTTCAA
TCTGGTGATATACTCGATGAATTGTTCGATAGTAGCTTAAAATGGTGTAA
GACTCCACTAAAAGATGTAATGAAGGTTCACGAGCACAAACCAGTTCGTT
TGTCAGTAGTTAAATTGCGATTGAAAGATGGAACCTTATTTCCACCAATA
CTACGTTTACTAAGAAAATATGAATTAATTCACCTGATTGAAGGTCGAGA
AATGAATCTCAGTATTCCAATATCCACTCCGTTACCAATTCATGCCAGAC
CAAATGATTTGTTTCCCGATGATGTTCCAGCTCCGAACCCAAACATGTCA
CCTCATTACGGTTTACGGTACGTTGGGTCGACTTATGTCGGCTCTTATGG
GGGTGTATCTAAAATCGAGTCTTCAATTGCTGAAACATTAAAGCATTATA
ATGATCCTTATTCATATGTACCGATATATATTGAATTAGGAGAAAAAGAT
GTATTAGTTCGGAAAGCATCTATTACTAAACAAGTCGATAATGTGAAAGG
CTCAGTGGATTCTATTGATAAAGAAATGAATCGCACTGATCCTCAAACAT
TACCGATTCTATTCGCTCATGCCTATCCACAAATAAGCTCATGTGGCAGG
CGAGTTGATTGTTCTCGCTTCTTGGCTTATATTGTAGGAGAAAGCACTTG
CGTGTTCTCCAAACATTTCGTCTGTCACGTATTTGAAGCCCGAAGTGAGC
CGGAATCCAAAGCAATTCTATGCAGTATTGCACAGGGATTTGAACGAACT
CATTGGACGATTTGAGAGAATATTTCCTATCGTTGAGATTTTATTCGATA
CAACAAATATTACGCAATTCTTTCCGGCTTCATCATCGAACGCATTTATG
TAAATGTCCCCTTTGGCAACAATCTCTCTTCTCAATGTTCGTTCGATAAT
TTAAGGATATTTTTGGACTTTTATTTATTATCTTGCTATTATTGTGATGA
TATTTTTTGGGCTTATTATTAATATAATTCCGTATTTGGGCTGGGTTTTA
TATCCAATTATTCCGTTTAAACAACTGTGATGGACTTTATCGATTTTTTG
TTACACTGCTTATATATTATTTTTTGTGTTGTAATAAAATGCTAAACCGG
G
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protein sequence of SMED30011972-orf-1

>SMED30011972-orf-1 ID=SMED30011972-orf-1|Name=SMED30011972-orf-1|organism=Schmidtea mediterranea sexual|type=polypeptide|length=494bp
MSMSDPLLKSLKKLIIDLCVVGSNDNIIISKEEIVDDNKALENLCEVIED
ILRKGLFRVGGLLGLEHRDYWCWFSELPKILKQHENQNPSSFKYKLHHRY
GDCLDIVKRYSEKVDTHQGKGRLMIRALIQNKILHWPFECLCLTVKSVSR
YYSDFNSLLNNEILAQMLISQLSQLSVLNFKLNLKNAMFLDETWTIPCYA
TYEFVPCKQLGVNLLAADAYQIVETVKKGSVAEEEKYFQSGDILDELFDS
SLKWCKTPLKDVMKVHEHKPVRLSVVKLRLKDGTLFPPILRLLRKYELIH
LIEGREMNLSIPISTPLPIHARPNDLFPDDVPAPNPNMSPHYGLRYVGST
YVGSYGGVSKIESSIAETLKHYNDPYSYVPIYIELGEKDVLVRKASITKQ
VDNVKGSVDSIDKEMNRTDPQTLPILFAHAYPQISSCGRRVDCSRFLAYI
VGESTCVFSKHFVCHVFEARSEPESKAILCSIAQGFERTHWTI*
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Annotated Terms
The following terms have been associated with this transcript:
Vocabulary: INTERPRO
TermDefinition
IPR037213Run_dom_sf
IPR004012Run_dom
IPR011993PH-like_dom_sf
IPR006020PTB/PI_dom
Vocabulary: molecular function
TermDefinition
GO:0005515protein binding
InterPro
Analysis Name: Schmidtea mediteranean smed_20140614 Interproscan
Date Performed: 2020-05-01
IPR TermIPR DescriptionSourceSource TermSource DescriptionAlignment
IPR011993PH-like domain superfamilyGENE3DG3DSA:2.30.29.30coord: 333..491
e-value: 1.1E-10
score: 43.2
IPR004012RUN domainPFAMPF02759RUNcoord: 43..185
e-value: 2.4E-10
score: 40.5
IPR004012RUN domainPROSITEPS50826RUNcoord: 35..187
score: 17.006
IPR006020PTB/PI domainPFAMPF00640PIDcoord: 413..489
e-value: 2.5E-4
score: 21.1
IPR006020PTB/PI domainPROSITEPS01179PIDcoord: 385..487
score: 8.691
IPR037213RUN domain superfamilyGENE3DG3DSA:1.20.58.900coord: 3..190
e-value: 6.1E-23
score: 83.4
IPR037213RUN domain superfamilySUPERFAMILYSSF140741RUN domain-likecoord: 31..187
NoneNo IPR availablePANTHERPTHR19964:SF78SI:CH211-250N8.1coord: 1..297
NoneNo IPR availablePANTHERPTHR19964MULTIPLE PDZ DOMAIN PROTEINcoord: 1..297
NoneNo IPR availableSUPERFAMILYSSF50729PH domain-likecoord: 337..488