Anaphase-promoting complex subunit 2

Overview


Name	Anaphase-promoting complex subunit 2
Smed ID	SMED30011868
Length (bp)	1516

Neoblast Clusters

▻ Sub-lethal Irradiated Surviving X1 and X2 Cell Population

Overview

Single cell RNA-seq of pluripotent neoblasts and its early progenies

We isolated X1 neoblasts cells enriched in high piwi-1 expression (Neoblast Population), and profiled ∼7,614 individual cells via scRNA-seq. Unsupervised analyses uncovered 12 distinct classes from 7,088 high-quality cells. We designated these classes Nb1 to Nb12 and ordered them based on high (Nb1) to low (Nb12) piwi-1 expression levels. We further defined groups of genes that best classified the cells parsed into 12 distinct cell clusters to generate a scaled expression heat map of discriminative gene sets for each cluster. Expression of each cluster’s gene signatures was validated using multiplex fluorescence in situ hybridization (FISH) co-stained with piwi-1 and largely confirmed the cell clusters revealed by scRNA-seq.

We also tested sub-lethal irradiation exposure. To profile rare pluripotent stem cells (PSCs) and avoid interference from immediate progenitor cells, we determined a time point after sub-lethal irradiation (7 DPI) with minimal piwi-1+ cells, followed by isolation and single-cell RNA-seq of 1,200 individual cells derived from X1 (Piwi-1 high) and X2 (Piwi-1 low) cell populations (Sub-lethal Irradiated Surviving X1 and X2 Cell Population)

Explore this single cell expression dataset with our NB Cluster Shiny App

Neoblast Population

t-SNE plot shows two-dimensional representation of global gene expression relationships among all neoblasts (n = 7,088 after filter). Cluster identity was assigned based on the top 10 marker genes of each cluster (Table S2), followed by inspection of RNA in situ hybridization patterns. Neoblast groups, Nb.

Expression of Anaphase-promoting complex subunit 2 (SMED30011868) t-SNE clustered cells

Violin plots show distribution of expression levels for Anaphase-promoting complex subunit 2 (SMED30011868) in cells (dots) of each of the 12 neoblast clusters.

Sub-lethal Irradiated Surviving X1 and X2 Cell Population

t-SNE plot of surviving X1 and X2 cells (n = 1,039 after QC filter) after sub-lethal irradiation. Colors indicate unbiased cell classification via graph-based clustering. SL, sub-lethal irradiated cell groups.

Expression of Anaphase-promoting complex subunit 2 (SMED30011868) in the t-SNE clustered sub-lethally irradiated X1 and X2 cells.

Violin plots show distribution of expression levels for Anaphase-promoting complex subunit 2 (SMED30011868) in cells (dots) of each of the 10 clusters of sub-leathally irradiated X1 and X2 cells.

Embryonic Expression

Davies et. al., 2017

Hover the mouse over a column in the graph to view average RPKM values per sample.
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Embryonic Stages: Y: yolk. S2-S8: Stages 2-8. C4: asexual adult. SX: virgin, sexually mature adult.
For further information about sample preparation and analysis for the single animal RNA-Seq experiment, please refer to the Materials and Methods

Anatomical Expression

PAGE et. al., 2020

SMED30011868

has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGE

PAGE Curations: 2

Expressed In	Reference Transcript	Gene Models	Published Transcript	Transcriptome	Publication	Specimen	Lifecycle	Evidence
X1 cell	SMED30011868	SMESG000048530.1 SMESG000022225.1	SmedASXL_015019	SmedAsxl_ww_GCZZ01	PMID:26114597 Zhu et al., 2015
neoblast	SMED30011868	SMESG000048530.1 SMESG000022225.1	dd_Smed_v4_7937_0_1	dd_Smed_v4	PMID:29674431 Fincher et al., 2018

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Homology

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BLAST of Anaphase-promoting complex subunit 2 vs. Ensembl Human
Match: ANAPC2 (anaphase promoting complex subunit 2 [Source:HGNC Symbol;Acc:HGNC:19989])

HSP 1 Score: 174.866 bits (442), Expect = 1.851e-46
Identity = 111/356 (31.18%), Postives = 200/356 (56.18%), Query Frame = 1

Query:  421 EMHDWIPDPIDS-VGIRSLWYKRLDVLSLLLSIYNSRELFASEYKNLLSQRLVKKIDFDVDKELRNLETLKLRFGQDYLQDCDVMLKDIRESRRINNTIQEKFS--LSDTVPEFNIQSYVISAEYWSKMIEKEFQLPEKLKIWFDKYSKHYSDYKRNRELKWYQILGSVEIEVELHNKSLKMDVSPLQATIIYCFSEKPRWEXXXXXXXXXXXXXXVRRAINFWLQKDFLKRVKEHGILESYEILXXXXXXXXXXXXXXXXXXXXXXXXXXNGETNSKNEMYQNLWMIIKFILTHASTQKQSMDIDKIFSTLPTYTSGDP--IKITKEQLEIFMDNKVTQKLLVVNHKNYYLNKSA 1473
            E  DW+PDP+D+  G  S   +  D++SLL+SIY S++LF +EY++LL+ RL+ +  F  ++E+RN+E LKLRFG+  +  C+VMLKD+ +SRRIN  I+E+     ++  P F + + ++S+E+W    +++ ++PE ++   + Y K Y   K  R L W   LG V ++VEL +++L + V+P+QA I+  F ++  W L  L++ +++ ++++RR ++ WLQ+  L R +  G     E     E    D    ++    D        + + K E     W  I+ +LT+     +S+ +D+I++ L  +    P   +I  ++L+ ++  KV  + LV +   Y L K+ 
Sbjct:  476 EPEDWVPDPVDADPGKSSSKRRSSDIISLLVSIYGSKDLFINEYRSLLADRLLHQFSFSPEREIRNVELLKLRFGEAPMHFCEVMLKDMADSRRINANIREEDEKRPAEEQPPFGVYAVILSSEFWPPFKDEKLEVPEDIRAALEAYCKKYEQLKAMRTLSWKHTLGLVTMDVELADRTLSVAVTPVQAVILLYFQDQASWTLEELSKAVKMPVALLRRRMSVWLQQGVL-REEPPGTFSVIE-----EERPQDRDNMVLIDSDDESDSGMASQADQKEEELLLFWTYIQAMLTNL----ESLSLDRIYNMLRMFVVTGPALAEIDLQELQGYLQKKVRDQQLVYSAGVYRLPKNC 821

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BLAST of Anaphase-promoting complex subunit 2 vs. Ensembl Human
Match: CUL4B (cullin 4B [Source:HGNC Symbol;Acc:HGNC:2555])

HSP 1 Score: 52.7582 bits (125), Expect = 1.361e-6
Identity = 38/174 (21.84%), Postives = 73/174 (41.95%), Query Frame = 1

Query:  481 KRLDVLSLLLSIYNSRELFASEYKNLLSQRLVKKIDFDVDKELRNLETLKLRFGQDYLQDCDVMLKDIRESRRINNTIQEKFSLSDTVPEFNIQSYVISAEYWSKMIEKEFQLPEKLKIWFDKYSKHYSDYKRNRELKWYQILGSVEIEVELHNKSLKMDVSPLQATIIYCFSE 1002
            K LD + ++      +++F + YK  L++RL+      VD E   L  LK   G  +    + M KD+  S+ I    ++     +      +   +++  YW   +  E  LP ++    + +   Y      R+L+W   LG   ++ E      ++ VS  Q  ++  F+E
Sbjct:  389 KMLDKIMIIFRFIYGKDVFEAFYKKDLAKRLLVGKSASVDAEKSMLSKLKHECGAAFTSKLEGMFKDMELSKDIMIQFKQYMQNQNVPGNIELTVNILTMGYWPTYVPMEVHLPPEMVKLQEIFKTFYLGKHSGRKLQWQSTLGHCVLKAEFKEGKKELQVSLFQTLVLLMFNE 562

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BLAST of Anaphase-promoting complex subunit 2 vs. Ensembl Human
Match: CUL4B (cullin 4B [Source:HGNC Symbol;Acc:HGNC:2555])

HSP 1 Score: 52.7582 bits (125), Expect = 1.366e-6
Identity = 42/176 (23.86%), Postives = 76/176 (43.18%), Query Frame = 1

Query:  481 KRLDVLSLLLSIYNSRELFASEYKNLLSQRLVKKIDFDVDKELRNLETLKLRFGQDYLQDCDVMLKDIRESRRINNTI-QEKFSLSDTVP-EFNIQSYVISAEYWSKMIEKEFQLPEKLKIWFDKYSKHYSDYKRNRELKWYQILGSVEIEVELHNKSLKMDVSPLQATIIYCFSE 1002
            K LD + ++      +++F + YK  L++RL+      VD E   L  LK   G  +    + M KD+  S+ I     Q K+  +  VP    +   +++  YW   +  E  LP ++    + +   Y      R+L+W   LG   ++ E      ++ VS  Q  ++  F+E
Sbjct:  567 KMLDKIMIIFRFIYGKDVFEAFYKKDLAKRLLVGKSASVDAEKSMLSKLKHECGAAFTSKLEGMFKDMELSKDIMIQFKQVKYMQNQNVPGNIELTVNILTMGYWPTYVPMEVHLPPEMVKLQEIFKTFYLGKHSGRKLQWQSTLGHCVLKAEFKEGKKELQVSLFQTLVLLMFNE 742

[Close]

BLAST of Anaphase-promoting complex subunit 2 vs. Ensembl Human
Match: CUL4B (cullin 4B [Source:HGNC Symbol;Acc:HGNC:2555])

HSP 1 Score: 52.373 bits (124), Expect = 1.708e-6
Identity = 38/174 (21.84%), Postives = 73/174 (41.95%), Query Frame = 1

Query:  481 KRLDVLSLLLSIYNSRELFASEYKNLLSQRLVKKIDFDVDKELRNLETLKLRFGQDYLQDCDVMLKDIRESRRINNTIQEKFSLSDTVPEFNIQSYVISAEYWSKMIEKEFQLPEKLKIWFDKYSKHYSDYKRNRELKWYQILGSVEIEVELHNKSLKMDVSPLQATIIYCFSE 1002
            K LD + ++      +++F + YK  L++RL+      VD E   L  LK   G  +    + M KD+  S+ I    ++     +      +   +++  YW   +  E  LP ++    + +   Y      R+L+W   LG   ++ E      ++ VS  Q  ++  F+E
Sbjct:  567 KMLDKIMIIFRFIYGKDVFEAFYKKDLAKRLLVGKSASVDAEKSMLSKLKHECGAAFTSKLEGMFKDMELSKDIMIQFKQYMQNQNVPGNIELTVNILTMGYWPTYVPMEVHLPPEMVKLQEIFKTFYLGKHSGRKLQWQSTLGHCVLKAEFKEGKKELQVSLFQTLVLLMFNE 740

[Close]

BLAST of Anaphase-promoting complex subunit 2 vs. Ensembl Human
Match: CUL4B (cullin 4B [Source:HGNC Symbol;Acc:HGNC:2555])

HSP 1 Score: 52.373 bits (124), Expect = 1.864e-6
Identity = 38/174 (21.84%), Postives = 73/174 (41.95%), Query Frame = 1

Query:  481 KRLDVLSLLLSIYNSRELFASEYKNLLSQRLVKKIDFDVDKELRNLETLKLRFGQDYLQDCDVMLKDIRESRRINNTIQEKFSLSDTVPEFNIQSYVISAEYWSKMIEKEFQLPEKLKIWFDKYSKHYSDYKRNRELKWYQILGSVEIEVELHNKSLKMDVSPLQATIIYCFSE 1002
            K LD + ++      +++F + YK  L++RL+      VD E   L  LK   G  +    + M KD+  S+ I    ++     +      +   +++  YW   +  E  LP ++    + +   Y      R+L+W   LG   ++ E      ++ VS  Q  ++  F+E
Sbjct:  572 KMLDKIMIIFRFIYGKDVFEAFYKKDLAKRLLVGKSASVDAEKSMLSKLKHECGAAFTSKLEGMFKDMELSKDIMIQFKQYMQNQNVPGNIELTVNILTMGYWPTYVPMEVHLPPEMVKLQEIFKTFYLGKHSGRKLQWQSTLGHCVLKAEFKEGKKELQVSLFQTLVLLMFNE 745

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BLAST of Anaphase-promoting complex subunit 2 vs. Ensembl Celegans
Match: apc-2 (Anaphase-promoting complex subunit 2 [Source:UniProtKB/Swiss-Prot;Acc:P34514])

HSP 1 Score: 120.939 bits (302), Expect = 7.616e-29
Identity = 75/230 (32.61%), Postives = 137/230 (59.57%), Query Frame = 1

Query:  430 DWIPDPIDS-VGIRSLWYKRLDVLSLLLSIYNSRELFASEYKNLLSQRLVKKIDFDVDKELRNLETLKLRFGQDYLQDCDVMLKDIRESRRINNTIQ---EKFSLSDTVPEFNIQSYVISAEYWSKM-IEK-EFQLPEKLKIWFDKYSKHYSDYKRNRELKWYQILGSVEIEVELHNKSLKMDVSPLQATIIYCFSEKPRWEXXXXXXXXXXXXXXVRRAINFWLQKDFL 1101
            +W+P+P D+ VG  +  ++ +DV ++L+S+Y S+ELF  EY+NLL++RL    + D + E R L+ LKLRF    LQ C+VML+D+  S  I+   +   E+ + +  VP   I + +IS+ YW K+  EK E  +P+ L+   D Y + Y D KR+R+L+W + +G VE+ + +    +   +  + A +++ F EK  W  A + + + +++ V R+ + + +++ F+
Sbjct:  379 NWMPNPTDATVGDGAPGHQGVDVFNMLVSVYGSKELFVKEYRNLLAERLSSSDNKDPEFEKRYLDLLKLRFQYSELQHCEVMLRDVIHSLDIDKKFEDMSERSAGNYDVPIIPISACIISSHYWPKLETEKTEALMPQPLQAAMDVYQETYLDVKRDRKLEWLRSVGCVEVSINIDGVEVDRTIPNMYALLLFLFLEKETWTTAEVVEKMGMSVVVTRKRLEWLVKQGFI 608

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BLAST of Anaphase-promoting complex subunit 2 vs. Ensembl Fly
Match: mr (gene:FBgn0002791 transcript:FBtr0072156)

HSP 1 Score: 184.496 bits (467), Expect = 2.725e-50
Identity = 116/357 (32.49%), Postives = 200/357 (56.02%), Query Frame = 1

Query:  430 DWIPDP--IDSVGIR---SLWYKRLDVLSLLLSIYNSRELFASEYKNLLSQRLVKKIDFDVDKELRNLETLKLRFGQDYLQDCDVMLKDIRESRRINNTIQEKFSLSDTVPEFNIQSYVISAEYWSKMIEKEFQLPEKLKIWFDKYSKHYSDYKRNRELKWYQILGSVEIEVELHNKSLKMDVSPLQATIIYCFSEKPRWEXXXXXXXXXXXXXXVRRAINFWLQKDFLKRVKEHGILES-----YEILXXXXXXXXXXXXXXXXXXXXXXXXXXNGETNSKNEMYQNLWMIIKFILTHASTQKQSMDIDKIFSTLPTYTS-GDPIKITKEQLEIFMDNKVTQKLLVVNHKNYYLNK 1467
            +W PDP  ID+  ++   S   +  D++S+++ IY S+ELF +EY+NL++ RL+ ++DF+ +KE+RNLE LK+RFG+  L  C+VMLKD+ +S+RIN  I      ++    F+I S ++SA++W    ++  QLPE+++  F KY+K Y  YK NR L W  + G V IE+E+ +++++M VSP+ A IIY F  K  W +  L+   ++  S +RR ++FW         + HG++       + +L+ E  +   +   + + D +         ++ + E  Q  W  I  +LT+      SM ID+I   L  + S    ++ T+++L+ F+  KV +  L+ +   Y L K
Sbjct:  460 NWQPDPFGIDASIMQYNSSRKMRSADIISMVVDIYGSKELFMTEYRNLMADRLLAQLDFNSEKEIRNLELLKIRFGESLLHSCEVMLKDVTDSKRINAHIHSDGDRTEN-QLFDISSLIVSAQFWPSFNKESLQLPEEIENEFKKYTKAYEAYKGNRTLNWRTVTGRVNIEIEIGDRTMEMVVSPILAVIIYHFQTKNEWTIEDLSSITKVPASALRRRLSFW---------QNHGLISETTPGIFTLLEKESEKSQYEDMSLAEADEEDLESAMASASDQREEELQVFWSYIVGMLTNL----DSMPIDRIHQMLKLFASHSGGVEFTQDELKHFLQRKVREHKLIFSGGVYQLAK 802

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BLAST of Anaphase-promoting complex subunit 2 vs. Ensembl Fly
Match: Cul4 (gene:FBgn0033260 transcript:FBtr0301355)

HSP 1 Score: 61.2326 bits (147), Expect = 1.680e-9
Identity = 44/177 (24.86%), Postives = 80/177 (45.20%), Query Frame = 1

Query:  481 KRLDVLSLLLSIYNSRELFASEYKNLLSQRLVKKIDFDVDKELRNLETLKLRFGQDYLQDCDVMLKDIRESRRINNTIQ-EKFSLSDTVPEFNIQSYVISAEYWSKMIEKEFQLPEKLKIWFDKYSKHYSDYKRNRELKWYQILGSVEIEVELHNKSLKMDVSPLQATIIYCFSEKP 1008
            K LD + +L    + +++F + YK  L++RL+      VD E   L  LK   G  +    + M KD+  SR IN   +    S +  V   ++   +++  YW      E  +P +       ++K Y +    R+L+W   LG+  +  +      ++ VS  QA ++  F++KP
Sbjct:  492 KTLDKIMVLFRFIHGKDVFEAFYKKDLAKRLLVGKSASVDSEKSMLSKLKQECGGGFTSKLEGMFKDMELSRDINIAFRGHALSNNRDVHNLDLCVSILTMGYWPTYAPTEVTMPPQFINPQQIFNKFYLEKHSGRKLQWQPTLGNCMLRAQFDAGPKELLVSLFQALVLLLFNDKP 668

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BLAST of Anaphase-promoting complex subunit 2 vs. Ensembl Fly
Match: Cul4 (gene:FBgn0033260 transcript:FBtr0088821)

HSP 1 Score: 61.2326 bits (147), Expect = 1.680e-9
Identity = 44/177 (24.86%), Postives = 80/177 (45.20%), Query Frame = 1

Query:  481 KRLDVLSLLLSIYNSRELFASEYKNLLSQRLVKKIDFDVDKELRNLETLKLRFGQDYLQDCDVMLKDIRESRRINNTIQ-EKFSLSDTVPEFNIQSYVISAEYWSKMIEKEFQLPEKLKIWFDKYSKHYSDYKRNRELKWYQILGSVEIEVELHNKSLKMDVSPLQATIIYCFSEKP 1008
            K LD + +L    + +++F + YK  L++RL+      VD E   L  LK   G  +    + M KD+  SR IN   +    S +  V   ++   +++  YW      E  +P +       ++K Y +    R+L+W   LG+  +  +      ++ VS  QA ++  F++KP
Sbjct:  492 KTLDKIMVLFRFIHGKDVFEAFYKKDLAKRLLVGKSASVDSEKSMLSKLKQECGGGFTSKLEGMFKDMELSRDINIAFRGHALSNNRDVHNLDLCVSILTMGYWPTYAPTEVTMPPQFINPQQIFNKFYLEKHSGRKLQWQPTLGNCMLRAQFDAGPKELLVSLFQALVLLLFNDKP 668

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BLAST of Anaphase-promoting complex subunit 2 vs. Ensembl Fly
Match: Cul5 (gene:FBgn0039632 transcript:FBtr0085417)

HSP 1 Score: 49.2914 bits (116), Expect = 8.194e-6
Identity = 42/174 (24.14%), Postives = 86/174 (49.43%), Query Frame = 1

Query:  490 DVLSLLLSIYNSRELFASEYKNLLSQRLVKKIDFDVDKELRNLETLK-LRFGQDYLQDCDVMLKDIRESRRINNTIQEKFSLSDTVPEFNIQSYVISAEYWSKMIEK-EFQLPEKLKIWFDKYSKHYSDYKRNRELKWYQILGSVEIEVELHNKSLKMDVSPLQATIIYCFSEK 1005
            DVL L+L   N++++F   +K  L++RL+     D +KE   +E L+ +    DY+     M +DI+ S  +N   +   S  D +   NI+  +++A  W++  E+    LP +L+ +     + Y      R+L+WY  + +  I    +     +DV+  Q  +++ ++++
Sbjct:  513 DVL-LVLKYVNNKDVFMRYHKVHLTRRLILGTSADSEKEEDIVEWLREVGMPADYVNRLARMFQDIKVSEDLNTQFRTSISRHDAI---NIK--ILNAGAWARCSERVSVSLPIELEDYIPDVEEFYKKKHSGRKLQWYHHMSNGTITFVNNFGRYDLDVTTFQMAVLFAWNQR 680

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BLAST of Anaphase-promoting complex subunit 2 vs. Ensembl Zebrafish
Match: anapc2 (anaphase promoting complex subunit 2 [Source:ZFIN;Acc:ZDB-GENE-081104-256])

HSP 1 Score: 173.711 bits (439), Expect = 2.514e-46
Identity = 108/352 (30.68%), Postives = 197/352 (55.97%), Query Frame = 1

Query:  430 DWIPDPIDSVGIRSLWYKRL-DVLSLLLSIYNSRELFASEYKNLLSQRLVKKIDFDVDKELRNLETLKLRFGQDYLQDCDVMLKDIRESRRINNTI--QEKFSLSDTVPEFNIQSYVISAEYWSKMIEKEFQLPEKLKIWFDKYSKHYSDYKRNRELKWYQILGSVEIEVELHNKSLK-MDVSPLQATIIYCFSEKPRWEXXXXXXXXXXXXXXVRRAINFWLQKDFLKRVKEHGILESYEILXXXXXXXXXXXXXXXXXXXXXXXXXXNGETNSKNEMYQNLWMIIKFILTHASTQKQSMDIDKIFSTLPTYTSGDP--IKITKEQLEIFMDNKVTQKLLVVNHKNYYLNK 1467
            DW PDP D++  ++   +R  D++SLL+SIY S+E+F +EYK +L+ RL+ +++++  +E+RN+E LKLRFG+ ++  C+VMLKD+ +SRRIN+ I  +E+   ++  P   + + +IS+E+W ++ E++ +LP       + Y+  +   K  R L+W   LGSV +++EL ++++  + VSP+ A II  F +K  W L  L+  L +   +VRR +  W Q+  L+  +E G    Y + +    +   ++  M+    +        ++  + E  Q  W  I+ +LT+     +SM +++I S L  + +  P   ++   +L+ F+  KV    L V+   Y L K
Sbjct:  456 DWTPDPTDALTDKTGSKRRSSDIISLLVSIYGSKEIFVNEYKTVLADRLLHQLNYNTAREIRNVELLKLRFGESHMHYCEVMLKDVADSRRINSNIHEEERRLPAEEQPTLPLSAMIISSEFWPQLKEEKMELPAVASKAMEDYTHRFEKLKAMRTLRWKPQLGSVTLDLELEDRTITDLTVSPIHAAIILHFQDKGTWTLEELSGVLGVPQEMVRRKLALWQQQGVLR--EEAG--GRYTVQETSTCKERSERSVMLIDSDEEGDSNTATQSEQREEKLQLFWAYIQAMLTNL----ESMTLERIHSMLRMFVAAGPGVTEMDVNELQAFLQKKVRAHQLTVSTGVYRLPK 799

[Close]

BLAST of Anaphase-promoting complex subunit 2 vs. Ensembl Zebrafish
Match: cul4b (cullin 4B [Source:ZFIN;Acc:ZDB-GENE-041008-208])

HSP 1 Score: 54.6842 bits (130), Expect = 2.059e-7
Identity = 38/174 (21.84%), Postives = 73/174 (41.95%), Query Frame = 1

Query:  481 KRLDVLSLLLSIYNSRELFASEYKNLLSQRLVKKIDFDVDKELRNLETLKLRFGQDYLQDCDVMLKDIRESRRINNTIQEKFSLSDTVPEFNIQSYVISAEYWSKMIEKEFQLPEKLKIWFDKYSKHYSDYKRNRELKWYQILGSVEIEVELHNKSLKMDVSPLQATIIYCFSE 1002
            K LD + ++      +++F + YK  L++RL+      VD E   L  LK   G  +    + M KD+  S+ I    ++     +      +   +++  YW   +  E  LP ++    + +   Y      R+L+W   LG   ++ E      ++ VS  Q  ++  F+E
Sbjct:  536 KMLDKIMIIFRFIYGKDVFEAFYKKDLAKRLLVGKSASVDAEKSMLSKLKHECGAAFTSKLEGMFKDMELSKDIMVQFKQHMQCQNIPGNIELTVNILTMGYWPTYVPMEVHLPAEMVRLQEIFKTFYLGKHSGRKLQWQSTLGHCVLKAEFKEGKKELQVSLFQTLVLLMFNE 709

[Close]

BLAST of Anaphase-promoting complex subunit 2 vs. Ensembl Zebrafish
Match: cul4b (cullin 4B [Source:ZFIN;Acc:ZDB-GENE-041008-208])

HSP 1 Score: 54.6842 bits (130), Expect = 2.377e-7
Identity = 38/174 (21.84%), Postives = 73/174 (41.95%), Query Frame = 1

Query:  481 KRLDVLSLLLSIYNSRELFASEYKNLLSQRLVKKIDFDVDKELRNLETLKLRFGQDYLQDCDVMLKDIRESRRINNTIQEKFSLSDTVPEFNIQSYVISAEYWSKMIEKEFQLPEKLKIWFDKYSKHYSDYKRNRELKWYQILGSVEIEVELHNKSLKMDVSPLQATIIYCFSE 1002
            K LD + ++      +++F + YK  L++RL+      VD E   L  LK   G  +    + M KD+  S+ I    ++     +      +   +++  YW   +  E  LP ++    + +   Y      R+L+W   LG   ++ E      ++ VS  Q  ++  F+E
Sbjct:  536 KMLDKIMIIFRFIYGKDVFEAFYKKDLAKRLLVGKSASVDAEKSMLSKLKHECGAAFTSKLEGMFKDMELSKDIMVQFKQHMQCQNIPGNIELTVNILTMGYWPTYVPMEVHLPAEMVRLQEIFKTFYLGKHSGRKLQWQSTLGHCVLKAEFKEGKKELQVSLFQTLVLLMFNE 709

[Close]

BLAST of Anaphase-promoting complex subunit 2 vs. Ensembl Zebrafish
Match: BX324225.3 (cullin 5b [Source:NCBI gene;Acc:100006147])

HSP 1 Score: 52.373 bits (124), Expect = 1.186e-6
Identity = 39/173 (22.54%), Postives = 86/173 (49.71%), Query Frame = 1

Query:  502 LLLSIYNSRELFASEYKNLLSQRLVKKIDFDVDKELRNLETLK-LRFGQDYLQDCDVMLKDIRESRRINNTIQEKFSLSD-TVPEFNIQSYVISAEYWSKMIEKEF-QLPEKLKIWFDKYSKHYSDYKRNRELKWYQILGSVEIEVELHNKSLKMDVSPLQATIIYCFSEKPR 1011
            L+L    ++++F   +K  L++RL+  I  D + E   +E L+ +    DY+     M +DI+ S  +N + +E    +   +P  ++   +++A  WS+  EK F  LP +L+    +  + Y      R+L W+ ++ +  I  +       ++V+  Q  +++ ++++PR
Sbjct:  439 LVLKYVQNKDVFMRYHKAHLTRRLILDISADSEIEENMVEWLREVGMPADYVNKLARMFQDIKVSEDLNQSFKEMHKHNKLALPADSVNIKILNAGAWSRSSEKVFVSLPTELEDLIPEVEEFYKKNHSGRKLHWHHLMSNGIITFKNEVGQYDLEVTTFQLAVLFAWNQRPR 611

[Close]

BLAST of Anaphase-promoting complex subunit 2 vs. Ensembl Zebrafish
Match: cul5b (cullin 5b [Source:ZFIN;Acc:ZDB-GENE-091113-45])

HSP 1 Score: 51.6026 bits (122), Expect = 1.749e-6
Identity = 39/173 (22.54%), Postives = 85/173 (49.13%), Query Frame = 1

Query:  502 LLLSIYNSRELFASEYKNLLSQRLVKKIDFDVDKELRNLETLK-LRFGQDYLQDCDVMLKDIRESRRINNTIQEKFSLSD-TVPEFNIQSYVISAEYWSKMIEKEF-QLPEKLKIWFDKYSKHYSDYKRNRELKWYQILGSVEIEVELHNKSLKMDVSPLQATIIYCFSEKPR 1011
            L+L    ++++F   +K  L++RL+  I  D + E   +E L+ +    DY+     M +DI+ S  +N + +E    +   +P  ++   +++A  WS+  EK F  LP +L+    +    Y      R+L W+ ++ +  I  +       ++V+  Q  +++ ++++PR
Sbjct:  439 LVLKYVQNKDVFMRYHKAHLTRRLILDISADSEIEENMVEWLREVGMPADYVNKLARMFQDIKVSEDLNQSFKEMHKHNKLALPADSVNIKILNAGAWSRSSEKVFVSLPTELEDLIPEVEDFYKKNHSGRKLHWHHLMSNGIITFKNEVGQYDLEVTTFQLAVLFAWNQRPR 611

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BLAST of Anaphase-promoting complex subunit 2 vs. Ensembl Xenopus
Match: lhx6 (LIM homeobox 6 [Source:Xenbase;Acc:XB-GENE-493341])

HSP 1 Score: 88.1965 bits (217), Expect = 7.092e-18
Identity = 41/87 (47.13%), Postives = 64/87 (73.56%), Query Frame = 1

Query:  421 EMHDWIPDPIDS-VGIRSLWYKRLDVLSLLLSIYNSRELFASEYKNLLSQRLVKKIDFDVDKELRNLETLKLRFGQDYLQDCDVMLK 678
            E  DW+PDP+D+  G  S   +  D++SLL+SIY S+ELF +EY+ LL++RL+ + ++  ++E+RN+E LKLRFG+  +  C+VMLK
Sbjct:  473 EAEDWLPDPVDADPGKSSSKRRSSDIISLLVSIYGSKELFINEYRTLLAERLLHQFNYSSEREIRNVELLKLRFGEAQMHYCEVMLK 559

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BLAST of Anaphase-promoting complex subunit 2 vs. Ensembl Xenopus
Match: dnlz (DNL-type zinc finger [Source:Xenbase;Acc:XB-GENE-940250])

HSP 1 Score: 53.9138 bits (128), Expect = 5.485e-7
Identity = 38/174 (21.84%), Postives = 74/174 (42.53%), Query Frame = 1

Query:  481 KRLDVLSLLLSIYNSRELFASEYKNLLSQRLVKKIDFDVDKELRNLETLKLRFGQDYLQDCDVMLKDIRESRRINNTIQEKFSLSDTVPEFNIQSYVISAEYWSKMIEKEFQLPEKLKIWFDKYSKHYSDYKRNRELKWYQILGSVEIEVELHNKSLKMDVSPLQATIIYCFSE 1002
            K LD + ++      +++F + YK  L++RL+      VD E   L  LK   G  +    + M KD+  S+ I    ++     +      +   +++  YW   +  E  LP ++    + +   Y      R+L+W   LG   ++ E +    ++ VS  Q  ++  F+E
Sbjct:  309 KMLDKIMIIFRFIYGKDVFEAFYKKDLAKRLLVGKSASVDAEKSMLSKLKHECGAAFTSKLEGMFKDMELSKDIMVHFKQYMQNQNVPGNIELTVNILTMGYWPTYVPMEVHLPPEMVKLQEIFKTFYLGKHSGRKLQWQSTLGQCVLKAEFNEGKKELQVSLFQTLVLLMFNE 482

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BLAST of Anaphase-promoting complex subunit 2 vs. Ensembl Xenopus
Match: dnlz (DNL-type zinc finger [Source:Xenbase;Acc:XB-GENE-940250])

HSP 1 Score: 53.9138 bits (128), Expect = 5.622e-7
Identity = 38/174 (21.84%), Postives = 74/174 (42.53%), Query Frame = 1

Query:  481 KRLDVLSLLLSIYNSRELFASEYKNLLSQRLVKKIDFDVDKELRNLETLKLRFGQDYLQDCDVMLKDIRESRRINNTIQEKFSLSDTVPEFNIQSYVISAEYWSKMIEKEFQLPEKLKIWFDKYSKHYSDYKRNRELKWYQILGSVEIEVELHNKSLKMDVSPLQATIIYCFSE 1002
            K LD + ++      +++F + YK  L++RL+      VD E   L  LK   G  +    + M KD+  S+ I    ++     +      +   +++  YW   +  E  LP ++    + +   Y      R+L+W   LG   ++ E +    ++ VS  Q  ++  F+E
Sbjct:  443 KMLDKIMIIFRFIYGKDVFEAFYKKDLAKRLLVGKSASVDAEKSMLSKLKHECGAAFTSKLEGMFKDMELSKDIMVHFKQYMQNQNVPGNIELTVNILTMGYWPTYVPMEVHLPPEMVKLQEIFKTFYLGKHSGRKLQWQSTLGQCVLKAEFNEGKKELQVSLFQTLVLLMFNE 616

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BLAST of Anaphase-promoting complex subunit 2 vs. Ensembl Xenopus
Match: dnlz (DNL-type zinc finger [Source:Xenbase;Acc:XB-GENE-940250])

HSP 1 Score: 53.9138 bits (128), Expect = 5.693e-7
Identity = 38/174 (21.84%), Postives = 74/174 (42.53%), Query Frame = 1

Query:  481 KRLDVLSLLLSIYNSRELFASEYKNLLSQRLVKKIDFDVDKELRNLETLKLRFGQDYLQDCDVMLKDIRESRRINNTIQEKFSLSDTVPEFNIQSYVISAEYWSKMIEKEFQLPEKLKIWFDKYSKHYSDYKRNRELKWYQILGSVEIEVELHNKSLKMDVSPLQATIIYCFSE 1002
            K LD + ++      +++F + YK  L++RL+      VD E   L  LK   G  +    + M KD+  S+ I    ++     +      +   +++  YW   +  E  LP ++    + +   Y      R+L+W   LG   ++ E +    ++ VS  Q  ++  F+E
Sbjct:  415 KMLDKIMIIFRFIYGKDVFEAFYKKDLAKRLLVGKSASVDAEKSMLSKLKHECGAAFTSKLEGMFKDMELSKDIMVHFKQYMQNQNVPGNIELTVNILTMGYWPTYVPMEVHLPPEMVKLQEIFKTFYLGKHSGRKLQWQSTLGQCVLKAEFNEGKKELQVSLFQTLVLLMFNE 588

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BLAST of Anaphase-promoting complex subunit 2 vs. Ensembl Xenopus
Match: dnlz (DNL-type zinc finger [Source:Xenbase;Acc:XB-GENE-940250])

HSP 1 Score: 53.5286 bits (127), Expect = 6.839e-7
Identity = 38/174 (21.84%), Postives = 74/174 (42.53%), Query Frame = 1

Query:  481 KRLDVLSLLLSIYNSRELFASEYKNLLSQRLVKKIDFDVDKELRNLETLKLRFGQDYLQDCDVMLKDIRESRRINNTIQEKFSLSDTVPEFNIQSYVISAEYWSKMIEKEFQLPEKLKIWFDKYSKHYSDYKRNRELKWYQILGSVEIEVELHNKSLKMDVSPLQATIIYCFSE 1002
            K LD + ++      +++F + YK  L++RL+      VD E   L  LK   G  +    + M KD+  S+ I    ++     +      +   +++  YW   +  E  LP ++    + +   Y      R+L+W   LG   ++ E +    ++ VS  Q  ++  F+E
Sbjct:  522 KMLDKIMIIFRFIYGKDVFEAFYKKDLAKRLLVGKSASVDAEKSMLSKLKHECGAAFTSKLEGMFKDMELSKDIMVHFKQYMQNQNVPGNIELTVNILTMGYWPTYVPMEVHLPPEMVKLQEIFKTFYLGKHSGRKLQWQSTLGQCVLKAEFNEGKKELQVSLFQTLVLLMFNE 695

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BLAST of Anaphase-promoting complex subunit 2 vs. Ensembl Mouse
Match: Anapc2 (anaphase promoting complex subunit 2 [Source:MGI Symbol;Acc:MGI:2139135])

HSP 1 Score: 168.703 bits (426), Expect = 1.585e-44
Identity = 110/356 (30.90%), Postives = 201/356 (56.46%), Query Frame = 1

Query:  421 EMHDWIPDPIDSVGIRSLWYKRL-DVLSLLLSIYNSRELFASEYKNLLSQRLVKKIDFDVDKELRNLETLKLRFGQDYLQDCDVMLKDIRESRRINNTIQEKFS--LSDTVPEFNIQSYVISAEYWSKMIEKEFQLPEKLKIWFDKYSKHYSDYKRNRELKWYQILGSVEIEVELHNKSLKMDVSPLQATIIYCFSEKPRWEXXXXXXXXXXXXXXVRRAINFWLQKDFLKRVKEHGILESYEILXXXXXXXXXXXXXXXXXXXXXXXXXXNGETNSKNEMYQNLWMIIKFILTHASTQKQSMDIDKIFSTLPTYTSGDP--IKITKEQLEIFMDNKVTQKLLVVNHKNYYLNKSA 1473
            E  DW+PDP+D+  ++S   +R  D++SLL+SIY S++LF +EY++LL+ RL+ +  F  ++E+RN+E LKLRFG+  +  C+VMLKD+ +SRRIN  I+E+      +  P F + + ++S+E+W    +++ ++PE ++   D Y K Y   K  R L W   LG V ++VEL +++L + V+P+QA ++  F  +  W L  L++ +++ ++++RR ++ WLQ+  L R +  G     E     E    D    ++    D        + + K E     W  I+ +LT+     +S+ +++I+S L  +    P   +I  ++L+ ++  KV  + L+ +   Y L K++
Sbjct:  491 EPEDWVPDPVDADPVKSSSKRRSSDIISLLVSIYGSKDLFINEYRSLLADRLLHQFSFSPEREIRNVELLKLRFGEAPMHFCEVMLKDMADSRRINANIREEDEKRPVEEQPPFGVYAVILSSEFWPPFKDEKLEVPEDIRAALDVYCKKYEKLKAMRTLSWKHTLGLVTMDVELADRTLSVAVTPVQAVVLLYFQNQASWTLEELSKVVKMPVALLRRRMSVWLQQGVL-REEPPGTFSVIE-----EERPQDRDNMVLIDSDDESDSGMASQADQKEEELLLFWAYIQAMLTNL----ESLSLERIYSMLRMFVMTGPALAEIDLQELQGYLQKKVRDQQLIYSAGVYRLPKNS 836

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BLAST of Anaphase-promoting complex subunit 2 vs. Ensembl Mouse
Match: Cul2 (cullin 2 [Source:MGI Symbol;Acc:MGI:1918995])

HSP 1 Score: 53.1434 bits (126), Expect = 5.528e-7
Identity = 40/177 (22.60%), Postives = 79/177 (44.63%), Query Frame = 1

Query:  490 DVLSLLLSIY---NSRELFASEYKNLLSQRLVKKIDFDVDKELRNLETLKLRFGQDYLQDCDVMLKDIRESRRINNTIQEKFSLSDTVPEFNI--QSYVISAEYW--SKMIEKEFQLPEKLKIWFDKYSKHYSDYKRNRELKWYQILGSVEIEVELHNKSLKMDVSPLQATIIYCFS 999
            D L+  ++++   + +++F   Y  +L++RL+  +   +D E   +  LK   G ++      M  D+  S  +NN         DTV +  I  Q YV+ A  W  ++     F +P++L+     +   YS +   R+L W   L + E+++    K     V+  Q  ++  F+
Sbjct:  350 DKLTSFITVFKYIDDKDVFQKFYARMLAKRLIHGLSMSMDSEEAMINKLKQACGYEFTSKLHRMYTDMSVSADLNNKFNNFIRNQDTVIDLGISFQIYVLQAGAWPLTQAPSSTFAIPQELEKSVQMFELFYSQHFSGRKLTWLHYLCTGEVKMNYLGKPYVAMVTTYQMAVLLAFN 526

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BLAST of Anaphase-promoting complex subunit 2 vs. Ensembl Mouse
Match: Cul2 (cullin 2 [Source:MGI Symbol;Acc:MGI:1918995])

HSP 1 Score: 53.1434 bits (126), Expect = 6.295e-7
Identity = 40/177 (22.60%), Postives = 79/177 (44.63%), Query Frame = 1

Query:  490 DVLSLLLSIY---NSRELFASEYKNLLSQRLVKKIDFDVDKELRNLETLKLRFGQDYLQDCDVMLKDIRESRRINNTIQEKFSLSDTVPEFNI--QSYVISAEYW--SKMIEKEFQLPEKLKIWFDKYSKHYSDYKRNRELKWYQILGSVEIEVELHNKSLKMDVSPLQATIIYCFS 999
            D L+  ++++   + +++F   Y  +L++RL+  +   +D E   +  LK   G ++      M  D+  S  +NN         DTV +  I  Q YV+ A  W  ++     F +P++L+     +   YS +   R+L W   L + E+++    K     V+  Q  ++  F+
Sbjct:  413 DKLTSFITVFKYIDDKDVFQKFYARMLAKRLIHGLSMSMDSEEAMINKLKQACGYEFTSKLHRMYTDMSVSADLNNKFNNFIRNQDTVIDLGISFQIYVLQAGAWPLTQAPSSTFAIPQELEKSVQMFELFYSQHFSGRKLTWLHYLCTGEVKMNYLGKPYVAMVTTYQMAVLLAFN 589

[Close]

BLAST of Anaphase-promoting complex subunit 2 vs. Ensembl Mouse
Match: Cul2 (cullin 2 [Source:MGI Symbol;Acc:MGI:1918995])

HSP 1 Score: 52.7582 bits (125), Expect = 8.181e-7
Identity = 40/177 (22.60%), Postives = 79/177 (44.63%), Query Frame = 1

Query:  490 DVLSLLLSIY---NSRELFASEYKNLLSQRLVKKIDFDVDKELRNLETLKLRFGQDYLQDCDVMLKDIRESRRINNTIQEKFSLSDTVPEFNI--QSYVISAEYW--SKMIEKEFQLPEKLKIWFDKYSKHYSDYKRNRELKWYQILGSVEIEVELHNKSLKMDVSPLQATIIYCFS 999
            D L+  ++++   + +++F   Y  +L++RL+  +   +D E   +  LK   G ++      M  D+  S  +NN         DTV +  I  Q YV+ A  W  ++     F +P++L+     +   YS +   R+L W   L + E+++    K     V+  Q  ++  F+
Sbjct:  413 DKLTSFITVFKYIDDKDVFQKFYARMLAKRLIHGLSMSMDSEEAMINKLKQACGYEFTSKLHRMYTDMSVSADLNNKFNNFIRNQDTVIDLGISFQIYVLQAGAWPLTQAPSSTFAIPQELEKSVQMFELFYSQHFSGRKLTWLHYLCTGEVKMNYLGKPYVAMVTTYQMAVLLAFN 589

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BLAST of Anaphase-promoting complex subunit 2 vs. Ensembl Mouse
Match: Cul4a (cullin 4A [Source:MGI Symbol;Acc:MGI:1914487])

HSP 1 Score: 52.7582 bits (125), Expect = 9.213e-7
Identity = 37/172 (21.51%), Postives = 71/172 (41.28%), Query Frame = 1

Query:  487 LDVLSLLLSIYNSRELFASEYKNLLSQRLVKKIDFDVDKELRNLETLKLRFGQDYLQDCDVMLKDIRESRRINNTIQEKFSLSDTVPEFNIQSYVISAEYWSKMIEKEFQLPEKLKIWFDKYSKHYSDYKRNRELKWYQILGSVEIEVELHNKSLKMDVSPLQATIIYCFSE 1002
            LD + +L    + +++F + YK  L++RL+      VD E   L  LK   G  +    + M KD+  S+ I    ++           ++   +++  YW      E  LP ++    + +   Y      R+L+W   LG   ++ +      +  VS  Q  ++  F+E
Sbjct:  433 LDKIMILFRFIHGKDVFEAFYKKDLAKRLLVGKSASVDAEKSMLSKLKHECGAAFTSKLEGMFKDMELSKDIMVHFKQHMQNQSAPGPIDLTVNILTMGYWPTYTPMEVHLPPEMVRLQEVFKTFYLGKHSGRKLQWQTTLGHAVLKADFKEGKKEFQVSLFQTLVLLMFNE 604

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BLAST of Anaphase-promoting complex subunit 2 vs. UniProt/SwissProt
Match: sp|Q9UJX6|ANC2_HUMAN (Anaphase-promoting complex subunit 2 OS=Homo sapiens OX=9606 GN=ANAPC2 PE=1 SV=1)

HSP 1 Score: 174.866 bits (442), Expect = 8.888e-46
Identity = 111/356 (31.18%), Postives = 200/356 (56.18%), Query Frame = 1

Query:  421 EMHDWIPDPIDS-VGIRSLWYKRLDVLSLLLSIYNSRELFASEYKNLLSQRLVKKIDFDVDKELRNLETLKLRFGQDYLQDCDVMLKDIRESRRINNTIQEKFS--LSDTVPEFNIQSYVISAEYWSKMIEKEFQLPEKLKIWFDKYSKHYSDYKRNRELKWYQILGSVEIEVELHNKSLKMDVSPLQATIIYCFSEKPRWEXXXXXXXXXXXXXXVRRAINFWLQKDFLKRVKEHGILESYEILXXXXXXXXXXXXXXXXXXXXXXXXXXNGETNSKNEMYQNLWMIIKFILTHASTQKQSMDIDKIFSTLPTYTSGDP--IKITKEQLEIFMDNKVTQKLLVVNHKNYYLNKSA 1473
            E  DW+PDP+D+  G  S   +  D++SLL+SIY S++LF +EY++LL+ RL+ +  F  ++E+RN+E LKLRFG+  +  C+VMLKD+ +SRRIN  I+E+     ++  P F + + ++S+E+W    +++ ++PE ++   + Y K Y   K  R L W   LG V ++VEL +++L + V+P+QA I+  F ++  W L  L++ +++ ++++RR ++ WLQ+  L R +  G     E     E    D    ++    D        + + K E     W  I+ +LT+     +S+ +D+I++ L  +    P   +I  ++L+ ++  KV  + LV +   Y L K+ 
Sbjct:  476 EPEDWVPDPVDADPGKSSSKRRSSDIISLLVSIYGSKDLFINEYRSLLADRLLHQFSFSPEREIRNVELLKLRFGEAPMHFCEVMLKDMADSRRINANIREEDEKRPAEEQPPFGVYAVILSSEFWPPFKDEKLEVPEDIRAALEAYCKKYEQLKAMRTLSWKHTLGLVTMDVELADRTLSVAVTPVQAVILLYFQDQASWTLEELSKAVKMPVALLRRRMSVWLQQGVL-REEPPGTFSVIE-----EERPQDRDNMVLIDSDDESDSGMASQADQKEEELLLFWTYIQAMLTNL----ESLSLDRIYNMLRMFVVTGPALAEIDLQELQGYLQKKVRDQQLVYSAGVYRLPKNC 821

[Close]

BLAST of Anaphase-promoting complex subunit 2 vs. UniProt/SwissProt
Match: sp|Q8BZQ7|ANC2_MOUSE (Anaphase-promoting complex subunit 2 OS=Mus musculus OX=10090 GN=Anapc2 PE=1 SV=2)

HSP 1 Score: 168.703 bits (426), Expect = 1.109e-43
Identity = 110/356 (30.90%), Postives = 201/356 (56.46%), Query Frame = 1

Query:  421 EMHDWIPDPIDSVGIRSLWYKRL-DVLSLLLSIYNSRELFASEYKNLLSQRLVKKIDFDVDKELRNLETLKLRFGQDYLQDCDVMLKDIRESRRINNTIQEKFS--LSDTVPEFNIQSYVISAEYWSKMIEKEFQLPEKLKIWFDKYSKHYSDYKRNRELKWYQILGSVEIEVELHNKSLKMDVSPLQATIIYCFSEKPRWEXXXXXXXXXXXXXXVRRAINFWLQKDFLKRVKEHGILESYEILXXXXXXXXXXXXXXXXXXXXXXXXXXNGETNSKNEMYQNLWMIIKFILTHASTQKQSMDIDKIFSTLPTYTSGDP--IKITKEQLEIFMDNKVTQKLLVVNHKNYYLNKSA 1473
            E  DW+PDP+D+  ++S   +R  D++SLL+SIY S++LF +EY++LL+ RL+ +  F  ++E+RN+E LKLRFG+  +  C+VMLKD+ +SRRIN  I+E+      +  P F + + ++S+E+W    +++ ++PE ++   D Y K Y   K  R L W   LG V ++VEL +++L + V+P+QA ++  F  +  W L  L++ +++ ++++RR ++ WLQ+  L R +  G     E     E    D    ++    D        + + K E     W  I+ +LT+     +S+ +++I+S L  +    P   +I  ++L+ ++  KV  + L+ +   Y L K++
Sbjct:  491 EPEDWVPDPVDADPVKSSSKRRSSDIISLLVSIYGSKDLFINEYRSLLADRLLHQFSFSPEREIRNVELLKLRFGEAPMHFCEVMLKDMADSRRINANIREEDEKRPVEEQPPFGVYAVILSSEFWPPFKDEKLEVPEDIRAALDVYCKKYEKLKAMRTLSWKHTLGLVTMDVELADRTLSVAVTPVQAVVLLYFQNQASWTLEELSKVVKMPVALLRRRMSVWLQQGVL-REEPPGTFSVIE-----EERPQDRDNMVLIDSDDESDSGMASQADQKEEELLLFWAYIQAMLTNL----ESLSLERIYSMLRMFVMTGPALAEIDLQELQGYLQKKVRDQQLIYSAGVYRLPKNS 836

[Close]

BLAST of Anaphase-promoting complex subunit 2 vs. UniProt/SwissProt
Match: sp|Q8H1U5|APC2_ARATH (Anaphase-promoting complex subunit 2 OS=Arabidopsis thaliana OX=3702 GN=APC2 PE=1 SV=1)

HSP 1 Score: 141.354 bits (355), Expect = 2.193e-34
Identity = 97/355 (27.32%), Postives = 189/355 (53.24%), Query Frame = 1

Query:  433 WIPDPIDSVGIR-SLWYKRLDVLSLLLSIYNSRELFASEYKNLLSQRLVKKIDFDVDKELRNLETLKLRFGQDYLQDCDVMLKDIRESRRINNTIQEKFSLSDTVPEF--------NIQSYVISAEYWSKMIEKEFQLPEKLKIWFDKYSKHYSDYKRNRELKWYQILGSVEIEVELHNKSLKMDVSPLQATIIYCFSEKPRWEXXXXXXXXXXXXXXVRRAINFWLQKDFLKRVKEHGILESYEILXXXXXXXXXXXXXXXXXXXXXXXXXXNGETNSKNEMYQNLWMIIKFILTHASTQKQSMDIDKIFSTLPTYTSGDP-IKITKEQLEIFMDNKVTQKLLVVNHKNYYLNK 1467
            W PDP+++  ++ SL  +++D+L +L+ I  S+E   +EY+ +L+++L+ K D+D+D E+R +E LK+ FG+  +Q C++ML D+ +S+R+N  I++    S T  E          + S ++S  +W  + ++  +LP  +      Y+  Y + K  R+L W + LG+V++E++  +++++  VSP  A II  F EK  W    LA+ + + +  + R +NFW+ K  L   +E     S   +      I D  K   +  + G+ + +    + ++++ + + +  KFI+    T   SM +++I +TL  +   DP    + +QL+ F+   V+++ L      Y L K
Sbjct:  518 WEPDPVEADPLKGSLSQRKVDILGMLVDIIGSKEQLVNEYRVMLAEKLLNKTDYDIDTEIRTVELLKIHFGEASMQRCEIMLNDLIDSKRVNTNIKKA---SQTGAELRENELSVDTLTSTILSTNFWPPIQDEPLELPGPVDKLLSDYANRYHEIKTPRKLLWKKNLGTVKLELQFEDRAMQFTVSPTHAAIIMQFQEKKSWTYKDLAEVIGIPIDALNRRVNFWISKGVL---RESTGANSNSSVLTLVESITDSGKNEGEELLTGEEEGETSIASVEDQLRKEMTIYEKFIMGML-TNFGSMALERIHNTLKMFCVADPSYDKSLQQLQSFLSGLVSEEKLEFRDGMYLLKK 865

[Close]

BLAST of Anaphase-promoting complex subunit 2 vs. UniProt/SwissProt
Match: sp|P34514|ANC2_CAEEL (Anaphase-promoting complex subunit 2 OS=Caenorhabditis elegans OX=6239 GN=apc-2 PE=1 SV=3)

HSP 1 Score: 120.939 bits (302), Expect = 9.688e-28
Identity = 75/230 (32.61%), Postives = 137/230 (59.57%), Query Frame = 1

Query:  430 DWIPDPIDS-VGIRSLWYKRLDVLSLLLSIYNSRELFASEYKNLLSQRLVKKIDFDVDKELRNLETLKLRFGQDYLQDCDVMLKDIRESRRINNTIQ---EKFSLSDTVPEFNIQSYVISAEYWSKM-IEK-EFQLPEKLKIWFDKYSKHYSDYKRNRELKWYQILGSVEIEVELHNKSLKMDVSPLQATIIYCFSEKPRWEXXXXXXXXXXXXXXVRRAINFWLQKDFL 1101
            +W+P+P D+ VG  +  ++ +DV ++L+S+Y S+ELF  EY+NLL++RL    + D + E R L+ LKLRF    LQ C+VML+D+  S  I+   +   E+ + +  VP   I + +IS+ YW K+  EK E  +P+ L+   D Y + Y D KR+R+L+W + +G VE+ + +    +   +  + A +++ F EK  W  A + + + +++ V R+ + + +++ F+
Sbjct:  379 NWMPNPTDATVGDGAPGHQGVDVFNMLVSVYGSKELFVKEYRNLLAERLSSSDNKDPEFEKRYLDLLKLRFQYSELQHCEVMLRDVIHSLDIDKKFEDMSERSAGNYDVPIIPISACIISSHYWPKLETEKTEALMPQPLQAAMDVYQETYLDVKRDRKLEWLRSVGCVEVSINIDGVEVDRTIPNMYALLLFLFLEKETWTTAEVVEKMGMSVVVTRKRLEWLVKQGFI 608

[Close]

BLAST of Anaphase-promoting complex subunit 2 vs. UniProt/SwissProt
Match: sp|Q551S9|APC2_DICDI (Anaphase-promoting complex subunit 2 OS=Dictyostelium discoideum OX=44689 GN=anapc2 PE=3 SV=1)

HSP 1 Score: 119.398 bits (298), Expect = 4.743e-27
Identity = 71/209 (33.97%), Postives = 119/209 (56.94%), Query Frame = 1

Query:  433 WIPDPID------SVGIRSLWYKRL-----DVLSLLLSIYNSRELFASEYKNLLSQRLVKKIDFDVDKELRNLETLKLRFGQDYLQDCDVMLKDIRESRRINNTIQEKFSLSDT----------VPEFNIQSYVISAEYWSKMIEKEFQLPEKLKIWFDKYSKHYSDYKRNRELKWYQILGSVEIEVELHNKSLKMDVSPLQATIIYCF 996
            WIP+ ID      S+G              D +S L++IY+  +LF +EY+++LS RL+  +DFD+DKE++N+E LKLRFG   L +C++M+KD+ +S+R+N  I+    +++           + EF  ++ ++S  +W  +   EF+ P+ ++     YSK Y   K  R+L W Q LG V++++E+ N      VSP+ AT+I  F
Sbjct:  530 WIPNKIDGSSTTISIGNAKANNNNKKKKKKDTISHLVNIYDGIDLFINEYRSMLSDRLLSVVDFDLDKEIKNIELLKLRFGDSVLFNCEIMIKDMVDSKRLNLQIKNSQGVNNNNNNNNNNNNELKEF--ETLILSQLFWPTLKGDEFKYPKSIEKKMQIYSKEYERIKTPRQLIWKQHLGLVDLDLEIGNNIQSFQVSPIHATLIMLF 736

[Close]

BLAST of Anaphase-promoting complex subunit 2 vs. TrEMBL
Match: B3S490 (CULLIN_2 domain-containing protein (Fragment) OS=Trichoplax adhaerens OX=10228 GN=TRIADDRAFT_28922 PE=3 SV=1)

HSP 1 Score: 188.734 bits (478), Expect = 2.645e-50
Identity = 121/356 (33.99%), Postives = 212/356 (59.55%), Query Frame = 1

Query:  430 DWIPDPIDSV---GIRSLWYKRLDVLSLLLSIYNSRELFASEYKNLLSQRLVKKIDFDVDKELRNLETLKLRFGQDYLQDCDVMLKDIRESRRINNTIQEKFSLSDTVPE-----FNIQSYVISAEYWSKMIEKEFQLPEKLKIWFDKYSKHYSDYKRNRELKWYQILGSVEIEVELHNKSLKMDVSPLQATIIYCFSEKPRWEXXXXXXXXXXXXXXVRRAINFWLQKDFLKRVKEHGILESYEILXXXXXXXXXXXXXXXXXXXXXXXXXXNGETNSKNEMYQNLWMIIKFILTHASTQKQSMDIDKIFSTLPTY--TSGDPIKITKEQLEIFMDNKVTQKLLVVNHKNYYLNK 1467
            DW PDP+D++   G+ S ++K+ DVLS+L++IY S++LF+SEY+NLL+ RL+   DF+ DKE+R LE LKL+FG+  L DC+VMLKD+++S RI++ IQ   +++  V E       + + +IS  +W K  E++ +LP K++     ++KH+   K  R L W   LG V I++E+ N   +  V+PLQA+IIY F EK +W +  +++ LQ++ +++RR I++W+ +  LK       ++SY ++++         +      +   +D+   E     E+Y   W  I  +LT+      +M++D+I S+L  +  ++G+   ++   L++F+D KV ++ L  N+  Y L K
Sbjct:  136 DWSPDPVDAIARKGMTSGYHKKKDVLSMLVTIYGSKQLFSSEYRNLLAHRLLTLFDFNTDKEIRYLELLKLKFGETNLSDCEVMLKDVKDSCRISDHIQS--TMNKIVQEEKDDSLMLNTLIISENFWPKFKEEKLKLPPKIEKTMTAFAKHFEKLKAMRGLHWKYHLGLVNIQIEIANHQKQFSVTPLQASIIYLFQEKVQWTIEEISEELQVSSTILRRKISYWINQGLLKETP----VDSYNLVEDRITPEDAITEDDETTTVTSAADQHEEE----QELY---WSYIVGMLTNFP----AMELDRICSSLKLFIPSAGE---LSSRDLKMFLDKKVQEQKLTHNNGEYALVK 471

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BLAST of Anaphase-promoting complex subunit 2 vs. TrEMBL
Match: A0A1B0D9E0 (CULLIN_2 domain-containing protein OS=Phlebotomus papatasi OX=29031 PE=3 SV=1)

HSP 1 Score: 191.815 bits (486), Expect = 1.042e-49
Identity = 121/346 (34.97%), Postives = 197/346 (56.94%), Query Frame = 1

Query:  433 WIPDPIDSVGIRSLWYKRLDVLSLLLSIYNSRELFASEYKNLLSQRLVKKIDFDVDKELRNLETLKLRFGQDYLQDCDVMLKDIRESRRINNTIQEKFSLSDTVPEFNIQSYVISAEYWSKMIEKEFQLPEKLKIWFDKYSKHYSDYKRNRELKWYQILGSVEIEVELHNKSLKMDVSPLQATIIYCFSEKPRWEXXXXXXXXXXXXXXVRRAINFWLQKDFLKRVKEHGILESYEILXXXXXXXXXXXXXXXXXXXXXXXXXXNGETNSKNEMYQNLWMIIKFILTHASTQKQSMDIDKIFSTLPTYTSGD-PIKITKEQLEIFMDNKVTQKLLVVNHKNYYLNK 1467
            W PDP+D+   +   ++  D++S+++ IY S+ELF +EYKNLL++RL++++D + +KE+RNLE LKLRFG+  L  C+VMLKDI +S+RIN  IQ   + SDT   F   S ++SA++W    +++ +LPE ++  F+ Y K Y  YK NR L W  + G V +EVE   K ++  V+P QATIIY F EK  W L  L+  +++  SV+RR I +W     +K  K  G     E   + + E +  + + I  D +   +     ++ + E  Q  W  I  +LT+      S+ I++I   L  + S +  ++ + ++L+ F+  KV +  L+     Y+L K
Sbjct:  367 WNPDPVDANPSKVKPHRSADIISMVVDIYGSKELFVNEYKNLLAERLLQQLDLNSEKEIRNLELLKLRFGESVLHSCEVMLKDISDSKRINAHIQSDSNYSDT-KAFEFSSLILSAQFWPGFKKEDLELPEAIQSQFENYRKSYEAYKGNRTLHWRPVSGKVMLEVEHMGKCVEYSVTPTQATIIYHFQEKSEWNLNDLSSIMKIPPSVLRRKITYWQSHGLIKETKT-GSFILVEDTSDSDMEEMQTEPQDICDDDEESENVVASASDQREEELQVFWSYIVGMLTNL----DSLPIERIHQMLKMFASNEKGVEFSLDELKDFLQTKVREHQLIFASGVYHLPK 706

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BLAST of Anaphase-promoting complex subunit 2 vs. TrEMBL
Match: Q95TK2 (LD45730p OS=Drosophila melanogaster OX=7227 GN=mr PE=2 SV=1)

HSP 1 Score: 185.652 bits (470), Expect = 2.693e-49
Identity = 116/352 (32.95%), Postives = 198/352 (56.25%), Query Frame = 1

Query:  430 DWIPDP--IDSVGIR---SLWYKRLDVLSLLLSIYNSRELFASEYKNLLSQRLVKKIDFDVDKELRNLETLKLRFGQDYLQDCDVMLKDIRESRRINNTIQEKFSLSDTVPEFNIQSYVISAEYWSKMIEKEFQLPEKLKIWFDKYSKHYSDYKRNRELKWYQILGSVEIEVELHNKSLKMDVSPLQATIIYCFSEKPRWEXXXXXXXXXXXXXXVRRAINFWLQKDFLKRVKEHGILESYEILXXXXXXXXXXXXXXXXXXXXXXXXXXNGETNSKNEMYQNLWMIIKFILTHASTQKQSMDIDKIFSTLPTYTS-GDPIKITKEQLEIFMDNKVTQKLLVVNHKNYYLNK 1467
            +W PDP  ID+  ++   S   +  D++S+++ IY S+ELF +EY+NL++ RL+ ++DF+ +KE+RNLE LK+RFG+  L  C+VMLKD+ +S+RIN  I      ++    F+I S ++SA++W    ++  QLPE+++  F KY+K Y  YK NR L W  + G V IE+E+ +++++M VSP+ A IIY F  K  W +  L+   ++  S +RR ++FW     +      GI   + +L+ E  +   +   + + D +         ++ + E  Q  W  I  +LT+      SM ID+I   L  + S    ++ T+++L+ F+  KV +  L+ +   Y L K
Sbjct:  107 NWQPDPFGIDASIMQYNSSRKMRSADIISMVVDIYGSKELFMTEYRNLMADRLLAQLDFNSEKEIRNLELLKIRFGESLLHSCEVMLKDVTDSKRINAHIHSDGDRTEN-QLFDISSLIVSAQFWPSFNKESLQLPEEIENEFKKYTKAYEAYKGNRTLNWRTVTGRVNIEIEIGDRTMEMVVSPILAVIIYHFQTKNEWTIEDLSSITKVPASALRRRLSFWQNHGLISETTP-GI---FTLLEKESEKSQYEDMSLAEADEEDLESAMASASDQREEELQVFWSYIVGMLTNL----DSMPIDRIHQMLKLFASHSGGVEFTQDELKHFLQRKVREHKLIFSGGVYQLAK 449

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BLAST of Anaphase-promoting complex subunit 2 vs. TrEMBL
Match: B4LP09 (Uncharacterized protein, isoform A OS=Drosophila virilis OX=7244 GN=Dvir\GJ21890 PE=3 SV=1)

HSP 1 Score: 190.274 bits (482), Expect = 7.753e-49
Identity = 127/366 (34.70%), Postives = 201/366 (54.92%), Query Frame = 1

Query:  397 FKRLGTLREMHDWI---PDP--IDSVGIR---SLWYKRLDVLSLLLSIYNSRELFASEYKNLLSQRLVKKIDFDVDKELRNLETLKLRFGQDYLQDCDVMLKDIRESRRINNTIQEKFSLSDTVPEFNIQSYVISAEYWSKMIEKEFQLPEKLKIWFDKYSKHYSDYKRNRELKWYQILGSVEIEVELHNKSLKMDVSPLQATIIYCFSEKPRWEXXXXXXXXXXXXXXVRRAINFWLQKDFLKRVKEHGILESYEILXXXXXXXXXXXXXXXXXXXXXXXXXXNGETNSKNEMYQNLWMIIKFILTHASTQKQSMDIDKIFSTLPTYTS-GDPIKITKEQLEIFMDNKVTQKLLVVNHKNYYLNK 1467
            F +   L E  DW    PDP  ID   ++   S   +  D++S+++ IY S+ELF  EY+NL++ RL+ ++DF+ +KE+RNLE LK+RFG+  L  C+VMLKD+ +S+RIN+ I    +  D  P FNI S +ISA++W    ++  QLPE+L+  F K++K Y  YK NR L W  + G V I +E+  + L+M V P QA IIY F  K  W +  L+  +++  S +RR I+FW     +  + E GI   + +L+ E  +   ++  + D D +         ++ + E  Q  W  I  +LT+       M ID+I   L  + S    ++ T+E+L+ F+  KV +  L+ +   Y L K
Sbjct:  433 FGKDSHLNEFSDWETWEPDPFGIDPDVLKLNSSKLIRSADIISMVVDIYGSKELFMVEYRNLMADRLLSQLDFNSEKEIRNLELLKIRFGESLLHSCEVMLKDVTDSKRINSHIHGDGN-CDESPLFNISSLIISAQFWPSFNKESLQLPEELENEFKKFTKAYESYKGNRTLNWRTVTGRVNIVIEIGERILEMTVPPTQAVIIYHFQHKSEWSIEELSSLIKVPPSALRRRISFWQNHGLIAEI-EPGI---FALLEKESEKTQFEEVSITDADEEDLESAMASASDQREEELQVFWSYIVGMLTNL----DCMPIDRIHQMLKLFASHSGGVEFTQEELKHFLQRKVREHKLLFSGGVYQLAK 789

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BLAST of Anaphase-promoting complex subunit 2 vs. TrEMBL
Match: A0A084WCU6 (AGAP005048-PA-like protein OS=Anopheles sinensis OX=74873 GN=ZHAS_00016160 PE=3 SV=1)

HSP 1 Score: 189.504 bits (480), Expect = 1.195e-48
Identity = 116/350 (33.14%), Postives = 194/350 (55.43%), Query Frame = 1

Query:  430 DWIPDPID--SVGIRSLWY-KRLDVLSLLLSIYNSRELFASEYKNLLSQRLVKKIDFDVDKELRNLETLKLRFGQDYLQDCDVMLKDIRESRRINNTIQEKFSLSDTVPEFNIQSYVISAEYWSKMIEKEFQLPEKLKIWFDKYSKHYSDYKRNRELKWYQILGSVEIEVELHNKSLKMDVSPLQATIIYCFSEKPRWEXXXXXXXXXXXXXXVRRAINFWLQKDFLKRVKEHGILESYEILXXXXXXXXXXXXXXXXXXXXXXXXXXNGETNSKNEMYQNLWMIIKFILTHASTQKQSMDIDKIFSTLPTYTSGDPIKITKEQLEIFMDNKVTQKLLVVNHKNYYLNKS 1470
            DW P+P+D     ++S W  K  D++++++ IY S+E+F +EY+NLL++RL+   DF+ ++E++NLE LK+RFG+  L  CDVMLKDI +S+RIN  I    S     P F + + ++S+++W    ++  +LP  +K  FDK++K Y  YK NR L+W  + G V IEVE + K  +M V+P QATII  FSE+P+W+L  L   + +   V+R+ + FW  +  ++  KE+  +      D+ +       +     D D         ++ + E  Q  W  I+ +LT+      S+ +D+I   L  + S   +  T+++L+  +  KV +  LV     Y L K+
Sbjct:  416 DWNPNPVDEAPAALQSDWAGKTADIIAMVVGIYGSKEIFVNEYRNLLAERLLSPNDFNAEREIKNLELLKVRFGETLLHSCDVMLKDITDSKRINTHIFSPESGLTEQPPFRMSALIVSSQFWPTFKKETMELPTAIKDVFDKFTKAYESYKVNRTLQWTPLNGKVTIEVENNGKVQEMQVTPAQATIIIHFSEQPQWDLDSLGLKMNMPPIVLRKRLVFWQSQGMIRETKENFFVLVDSSADSGKQTEQAHTQSNDVCDEDEAESAMESASDQREEELQVFWSYIEAMLTNLD----SLPLDRIHQMLKLFASQ--VDFTQDELKSILQRKVREHKLVYAGGVYQLPKT 759

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BLAST of Anaphase-promoting complex subunit 2 vs. Ensembl Cavefish
Match: anapc2 (anaphase promoting complex subunit 2 [Source:NCBI gene;Acc:103044783])

HSP 1 Score: 172.94 bits (437), Expect = 3.630e-46
Identity = 108/358 (30.17%), Postives = 196/358 (54.75%), Query Frame = 1

Query:  430 DWIPDPIDSVGIRSLWYKRL-DVLSLLLSIYNSRELFASEYKNLLSQRLVKKIDFDVDKELRNLETLKLRFGQDYLQDCDVMLKDIRESRRINNTIQEKFS--LSDTVPEFNIQSYVISAEYWSKMIEKEFQLPEKLKIWFDKYSKHYSDYKRNRELKWYQILGSVEIEVELHNKSLK-MDVSPLQATIIYCFSEKPRWEXXXXXXXXXXXXXXVRRAINFWLQKDFLKRVKEHGILES-----YEILXXXXXXXXXXXXXXXXXXXXXXXXXXNGETNSKNEMYQNLWMIIKFILTHASTQKQSMDIDKIFSTLPTYTSGDP--IKITKEQLEIFMDNKVTQKLLVVNHKNYYLNKS 1470
            DW PDP D++  ++   +R  D++SLL+SIY S+++F  EYK +L+ RL+ + +++  +E+RN+E LKLRFG+  +  C+VMLKD+ +SRRIN  I E+ +    +  P   + S ++S+E+W ++ E++ +LP  +    + Y+  +   K  R L W   LGSV ++VEL +++L  + VSP+ A II  F +K  W L  L+  L ++  +VRR +  W         ++HG+++      Y +L+    +   ++  M+    +        ++  + E  Q  W  ++ +LT+     +SM +++I S L  + +  P   ++   +L+ F+  KV    L+V+   Y L KS
Sbjct:  471 DWTPDPTDALTDKTGSKRRSSDIISLLVSIYGSKDIFIDEYKTVLADRLLHQFNYNTAREIRNVELLKLRFGESIMHYCEVMLKDVADSRRINTNIHEEEAHLPVEEQPSIPLSSMILSSEFWPQLKEEKMELPAVVSKAMEAYTHRFEKLKAMRTLSWKPHLGSVTLDVELEDRTLSNLSVSPIHAAIILHFQDKGTWTLEELSGVLGVSQELVRRKLALW---------QQHGVVQEEAGGRYSVLETASSKERPERAVMLIDSDEEGDSNTATQSEQREEKLQLFWAYVQAMLTNL----ESMTLERIHSMLRMFVATGPGVTEMDANELQAFLQKKVRDHQLIVSAGVYRLPKS 815

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BLAST of Anaphase-promoting complex subunit 2 vs. Ensembl Cavefish
Match: ENSAMXT00000057183.1 (pep primary_assembly:Astyanax_mexicanus-2.0:APWO02001049.1:257741:270576:1 gene:ENSAMXG00000034138.1 transcript:ENSAMXT00000057183.1 gene_biotype:protein_coding transcript_biotype:protein_coding)

HSP 1 Score: 54.299 bits (129), Expect = 2.447e-7
Identity = 38/174 (21.84%), Postives = 73/174 (41.95%), Query Frame = 1

Query:  481 KRLDVLSLLLSIYNSRELFASEYKNLLSQRLVKKIDFDVDKELRNLETLKLRFGQDYLQDCDVMLKDIRESRRINNTIQEKFSLSDTVPEFNIQSYVISAEYWSKMIEKEFQLPEKLKIWFDKYSKHYSDYKRNRELKWYQILGSVEIEVELHNKSLKMDVSPLQATIIYCFSE 1002
            K LD + ++      +++F + YK  L++RL+      VD E   L  LK   G  +    + M KD+  S+ I    ++     +      +   +++  YW   +  E  LP ++    + +   Y      R+L+W   LG   ++ E      ++ VS  Q  ++  F+E
Sbjct:  307 KMLDKIMIIFRFIYGKDVFEAFYKKDLAKRLLVGKSASVDAEKSMLSKLKHECGAAFTSKLEGMFKDMELSKDIMVQFKQYMQCQNIPGNIELTVNILTMGYWPTYVPMEVHLPPEMVRLQEIFKTFYLGKHSGRKLQWQSTLGHCVLKAEFKEGKKELQVSLFQTLVLLMFNE 480

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BLAST of Anaphase-promoting complex subunit 2 vs. Ensembl Cavefish
Match: cul4b (cullin 4B [Source:ZFIN;Acc:ZDB-GENE-041008-208])

HSP 1 Score: 52.373 bits (124), Expect = 1.107e-6
Identity = 38/174 (21.84%), Postives = 72/174 (41.38%), Query Frame = 1

Query:  481 KRLDVLSLLLSIYNSRELFASEYKNLLSQRLVKKIDFDVDKELRNLETLKLRFGQDYLQDCDVMLKDIRESRRINNTIQEKFSLSDTVPEFNIQSYVISAEYWSKMIEKEFQLPEKLKIWFDKYSKHYSDYKRNRELKWYQILGSVEIEVELHNKSLKMDVSPLQATIIYCFSE 1002
            K LD + ++      +++F + YK  L++RL+      VD E   L  LK   G  +    + M KD+  S+ I    ++     +      +   +++  YW   +  E  LP ++    + +   Y      R+L+W   LG   ++ E      ++ VS  Q  +   F+E
Sbjct:  532 KMLDKIMIIFRFIYGKDVFEAFYKKDLAKRLLVGKSASVDAEKSMLSKLKHECGAAFTSKLEGMFKDMELSKDIMVQFKQYMQCQNIPGNIELTVNILTMGYWPTYVPMEVHLPPEMVRLQEIFKTFYLGKHSGRKLQWQSTLGHCVLKAEFKEGKKELQVSLFQTLVRLMFNE 705

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BLAST of Anaphase-promoting complex subunit 2 vs. Ensembl Cavefish
Match: cul4a (cullin 4A [Source:ZFIN;Acc:ZDB-GENE-040426-1357])

HSP 1 Score: 51.9878 bits (123), Expect = 1.206e-6
Identity = 43/174 (24.71%), Postives = 76/174 (43.68%), Query Frame = 1

Query:  487 LDVLSLLLSIYNSRELFASEYKNLLSQRLVKKIDFDVDKELRNLETLKLRFGQDYLQDCDVMLKDIRESRRINNTIQEKFSLSDTVPEFNIQSYV--ISAEYWSKMIEKEFQLPEKLKIWFDKYSKHYSDYKRNRELKWYQILGSVEIEVELHNKSLKMDVSPLQATIIYCFSE 1002
            LD + ++    + +++F + YK  L++RL+      VD E   L  LK   G  +    + M KD+  S+ I   IQ K  + +     NI+  V  ++  YW      E  LP ++    + +   Y      R+L+W   LG   ++ E      ++ VS  Q  ++  F+E
Sbjct:  286 LDKIMIIFRFIHGKDVFEAFYKKDLAKRLLVGKSASVDAEKSMLSKLKHECGAAFTSKLEGMFKDMELSKDI--MIQFKQYMQNQSEPSNIELTVNILTMGYWPTYTPMEVHLPAEMVKLQEVFKMFYLGKHSGRKLQWQPTLGHAVLKAEFKEGKKELQVSLFQTLVLLMFNE 457

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BLAST of Anaphase-promoting complex subunit 2 vs. Ensembl Cavefish
Match: cul5a (cullin 5 [Source:NCBI gene;Acc:103032672])

HSP 1 Score: 49.2914 bits (116), Expect = 8.393e-6
Identity = 37/166 (22.29%), Postives = 81/166 (48.80%), Query Frame = 1

Query:  523 SRELFASEYKNLLSQRLVKKIDFDVDKELRNLETLK-LRFGQDYLQDCDVMLKDIRESRRINNTIQEKFSLSD-TVPEFNIQSYVISAEYWSKMIEKEF-QLPEKLKIWFDKYSKHYSDYKRNRELKWYQILGSVEIEVELHNKSLKMDVSPLQATIIYCFSEKPR 1011
            ++++F   +K  L++RL+  I  D + E   +E L+ +    DY+     M +DI+ S  +N   +E    +   +P  ++   +++A  WS+  EK F  LP +L+    +    Y      R+L W+ ++ +  I  +       ++V+  Q  +++ ++++PR
Sbjct:  446 NKDVFMRYHKAHLTRRLILDISADSEIEENMVEWLREVGMPADYVNKLARMFQDIKVSEDLNQVFKEMHKHNKLALPADSVNIKILNAGAWSRSSEKVFVSLPTELEDLIPEVEDFYKKNHSGRKLHWHHLMSNGIITFKNEVGQYDLEVTTFQLAVLFAWNQRPR 611

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BLAST of Anaphase-promoting complex subunit 2 vs. Ensembl Sea Lamprey
Match: cul4b (cullin 4B [Source:ZFIN;Acc:ZDB-GENE-041008-208])

HSP 1 Score: 50.8322 bits (120), Expect = 5.398e-7
Identity = 37/172 (21.51%), Postives = 72/172 (41.86%), Query Frame = 1

Query:  487 LDVLSLLLSIYNSRELFASEYKNLLSQRLVKKIDFDVDKELRNLETLKLRFGQDYLQDCDVMLKDIRESRRINNTIQEKFSLSDTVPEFNIQSYVISAEYWSKMIEKEFQLPEKLKIWFDKYSKHYSDYKRNRELKWYQILGSVEIEVELHNKSLKMDVSPLQATIIYCFSE 1002
            LD + ++    + +++F + YK  L++RL+      VD E   L  LK   G  +    + M KD+  S+ I    ++     +      +   +++  YW      E  LP ++    + +   Y      R+L+W   LG   ++ E      ++ VS  Q  ++  F+E
Sbjct:  430 LDKIMIIFRFIHGKDVFEAFYKKDLAKRLLVGKSASVDAEKSMLSKLKHECGGAFTSKLEGMFKDMELSKDIMIQFKQYMQNQNDANNIELTVNILTMGYWPTYTPMEVHLPPEMVKLQEVFKTFYLGKHSGRKLQWQPSLGHCVLKSEFKEGKKELQVSLFQTLVLLMFNE 601

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BLAST of Anaphase-promoting complex subunit 2 vs. Ensembl Sea Lamprey
Match: cul2 (cullin 2 [Source:ZFIN;Acc:ZDB-GENE-030131-8032])

HSP 1 Score: 46.9802 bits (110), Expect = 9.173e-6
Identity = 36/164 (21.95%), Postives = 72/164 (43.90%), Query Frame = 1

Query:  520 NSRELFASEYKNLLSQRLVKKIDFDVDKELRNLETLKLRFGQDYLQDCDVMLKDIRESRRINNTIQEKFSLSDTVPEFNI--QSYVISAEYW--SKMIEKEFQLPEKLKIWFDKYSKHYSDYKRNRELKWYQILGSVEIEVELHNKSLKMDVSPLQATIIYCFS 999
            + +++F   Y  +L++RL+  +   +D E   +  LK   G ++      M  D+  S  +NN         +T  +  +  Q YV+ A  W  S++    F +P++L+     +   Y+D    R+L W   L + E+++    K     V+  Q  ++  F+
Sbjct:  424 DDKDVFQKFYARMLAKRLIHGLSMSMDSEESMINKLKQACGYEFTSKLHRMYTDMSLSADLNNKFGNFIKEQETPIDLGVGFQIYVLQAGAWPLSQLPSTPFVIPQELEKCVRMFEIFYNDSFNGRKLTWLHYLCTGEMKMNYLPKPYVATVTTYQMGVLLAFN 587

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BLAST of Anaphase-promoting complex subunit 2 vs. Ensembl Yeast
Match: APC2 (Subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C); which is a ubiquitin-protein ligase required for degradation of anaphase inhibitors, including mitotic cyclins, during the metaphase/anaphase transition; component of the catalytic core of the APC/C; has similarity to cullin Cdc53p [Source:SGD;Acc:S000004117])

HSP 1 Score: 62.3882 bits (150), Expect = 9.012e-11
Identity = 75/275 (27.27%), Postives = 123/275 (44.73%), Query Frame = 1

Query:  433 WIPDPIDSV--GIRSLWYKRLDVLSLLLSIYNSRELFASEYKNLLSQRLVKKIDFDVDKE-LRNLETLK---LRFG--------------------------QDYLQDCDVMLKDIRESRRINNTIQEKFSLSDTV-PEFNIQSYVISAEYWSKMIEKE------FQLPEKLKIWFDKYSKHYSDYKRNRELKWYQILGSVEIEVELHN-KSLKMDVSPLQATIIYCFSEKPRWEXXXXXXXXXXXXXXVR-----RAINFWLQKDFLKRVKEHG 1122
            W+P+P D +   I+S  Y + ++  +LL ++ SRE F SE++NLL+ RL     + +D++  R L+ ++   ++F                           Q  L   DVML DI+ S  +   + E   L   + P+F      IS  YW    + +      F LP  L+    KYS  YS  K  R+L+  +  G VEI++   + + L +DVS  Q ++I  F + P  E   L+         +        ++FW+QK  L  +KE+G
Sbjct:  470 WVPEPNDMIPGNIKS-SYIKTNLFEVLLDLFESREFFISEFRNLLTDRLFTLKFYTLDEKWTRCLKLIREKIVKFTETSHSNYITNGILGLLETTAPAADADQSNLNSIDVMLWDIKCSEELCRKMHEVAGLDPIIFPKF------ISLLYWKYNCDTQGSNDLAFHLPIDLERELQKYSDIYSQLKPGRKLQLCKDKGKVEIQLAFKDGRKLVLDVSLEQCSVINQF-DSPNDEPICLSLEQLSESLNIAPPRLTHLLDFWIQKGVL--LKENG 734

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BLAST of Anaphase-promoting complex subunit 2 vs. Ensembl Nematostella
Match: EDO33056 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7STC1])

HSP 1 Score: 174.096 bits (440), Expect = 6.551e-48
Identity = 112/353 (31.73%), Postives = 192/353 (54.39%), Query Frame = 1

Query:  430 DWIPDPIDSVGIRS-LWYKRLDVLSLLLSIYNSRELFASEYKNLLSQRLVKKIDFDVDKELRNLETLKLRFGQDYLQDCDVMLKDIRESRRINNTIQEKFSLSDTVP-EFNIQSYVISAEYWSKMIEKEFQLPEKLKIWFDKYSKHYSDYKRNRELKWYQILGSVEIEVELHNKSLKMDVSPLQATIIYCFSEKPRWEXXXXXXXXXXXXXXVRRAINFWLQKDFLKRVKEHGILESYEILXXXXXXXXXXXXXXXXXXXXXXXXXXNGETNSK-NEMYQNLWMIIKFILTHASTQKQSMDIDKIFSTLPTYTSGDP--IKITKEQLEIFMDNKVTQKLLVVNHKNYYLNKSA 1473
            DW+PDP+D+   RS    K  D++S+L++IY S++LF SEY+ LL+ R++   ++D D+ELR LE LKLRFG+ +L  C++MLKD+ +SRRIN+ I      +   P   +I + ++SA +W    E++ ++P+ ++    +Y   +   K  R L+W   LG VE+E+EL +++L + VSP+ AT I+ F EK RW+L  L+  + +    +RR + FW+ +  L+        ES +     E +    K    +V ++ + +        K  E  Q  W  I  +LT+     +S+ +++I S L  +    P   + +   L+ F+D KV ++ L   +  Y L K+ 
Sbjct:  234 DWVPDPVDAPPARSSRSGKAPDIISMLVNIYGSKDLFVSEYRTLLADRILSTFNYDTDRELRYLELLKLRFGESHLHFCEIMLKDVADSRRINSNIHSCRGRAGKKPLPVDINAMILSAVFWPLFREEKLKVPDAVETSMAEYRGGFEALKAMRTLEWKTHLGLVEVELELEDRTLSLSVSPVHATAIWHFQEKERWQLDELSSVMHVTPGTLRRRLAFWVSQGVLRE-------ESPDTYIVMERQKGIHKAHSAEVMVEAEPESATASVQQKREEELQVFWSYIVGMLTNL----ESLPLERIHSMLRIFAMQGPESAQCSVGDLKRFLDCKVKEQELQFANGFYRLPKTG 575

[Close]

BLAST of Anaphase-promoting complex subunit 2 vs. Ensembl Nematostella
Match: EDO38761 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7SC24])

HSP 1 Score: 51.9878 bits (123), Expect = 4.114e-7
Identity = 42/179 (23.46%), Postives = 91/179 (50.84%), Query Frame = 1

Query:  490 DVLSLLLSIYNSRELFASEYKNLLSQRLVKKIDFDVDKELRNLETLK-LRFGQDYLQDCDVMLKDIRESRRINN----TIQEKFSLSDTVPEFNIQSYVISAEYWSKMIEK-EFQLPEKLKIWFDKYSKHYSDYKRNRELKWYQILGSVEIEVELHNKSLKMDVSPLQATIIYCFSEKP 1008
            DVL +L  + N +++F   +K  L++RL+     D + E   +E L+ +    DY+     M +DI+ S  +N     T ++K  ++D++   NI+  +++A  WS+  E+    LP +L+    +  + Y      R+L+W+ ++ +  I          ++V+  Q ++++ ++E+P
Sbjct:  443 DVLLVLKYVVN-KDVFMRYHKAHLTRRLILDTSADSEMEENMVEWLRDVGMPADYINKLARMFQDIKVSEDLNQEFKRTCRDKGDIADSI---NIK--ILNAGAWSRASERIPVSLPTELEDCIPEVEEFYRKNHSGRKLQWHHLMSNGVITFSNKTGKFDLEVTTFQMSVLFAWNERP 615

[Close]

BLAST of Anaphase-promoting complex subunit 2 vs. Ensembl Nematostella
Match: EDO35660 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7SKY8])

HSP 1 Score: 48.9062 bits (115), Expect = 3.678e-6
Identity = 34/172 (19.77%), Postives = 75/172 (43.60%), Query Frame = 1

Query:  487 LDVLSLLLSIYNSRELFASEYKNLLSQRLVKKIDFDVDKELRNLETLKLRFGQDYLQDCDVMLKDIRESRRINNTIQEKFSLSDTVPEFNIQSYVISAEYWSKMIEKEFQLPEKLKIWFDKYSKHYSDYKRNRELKWYQILGSVEIEVELHNKSLKMDVSPLQATIIYCFSE 1002
            LD + ++    + ++++ + YK  L++RL+      VD E   L  LK   G  +    + M KD+  S+ +    ++           ++   +++  YW   +  +  LP ++  + + + K Y      R+L+W   LG   ++ +      ++ VS  Q  ++  F+E
Sbjct:  251 LDRIMVIFRFIHGKDVYEAFYKKDLAKRLLVGKSASVDAEKSMLSKLKQECGAAFTSKLEGMFKDMELSKDVMVQFRQYLQHQSLPWNMDMVVSILTMGYWPTYLPMDVHLPTEMVHYQETFKKFYLAKHSGRKLQWQNTLGHCVVKADFSEVKKELQVSLFQTLVLLMFNE 422

[Close]

BLAST of Anaphase-promoting complex subunit 2 vs. Ensembl Medaka
Match: anapc2 (anaphase promoting complex subunit 2 [Source:NCBI gene;Acc:101154953])

HSP 1 Score: 174.866 bits (442), Expect = 9.602e-47
Identity = 116/353 (32.86%), Postives = 198/353 (56.09%), Query Frame = 1

Query:  430 DWIPDPIDSVGIRSLWYKRL--DVLSLLLSIYNSRELFASEYKNLLSQRLVKKIDFDVDKELRNLETLKLRFGQDYLQDCDVMLKDIRESRRINNTIQEKFS-LS-DTVPEFNIQSYVISAEYWSKMIEKEFQLPEKLKIWFDKYSKHYSDYKRNRELKWYQILGSVEIEVELHNKSL-KMDVSPLQATIIYCFSEKPRWEXXXXXXXXXXXXXXVRRAINFWLQKDFLKRVKEHGILESYEILXXXXXXXXXXXXXXXXXXXXXXXXXXNGETNSKNEMYQNLWMIIKFILTHASTQKQSMDIDKIFSTLPTYTSGDPI--KITKEQLEIFMDNKVTQKLLVVNHKNYYLNK 1467
            DW PDP D+V  + L  KR   D++SLL+SIY S+++F  EY+ +L+ RL+++++++  +E+RN+E LKLRFG+ ++  C+VMLKD+ +SRRIN  I+E+ S LS D  P   + + ++S+E+W  + E++ +LP  +    + Y+  Y   K  R L W   LGSV ++VEL ++ L  + VSP+QA II  F +K  W L  L+  L     +V R +  W Q+  L+  +E G    Y +++        ++  M+    +        ++  + E  Q  W  I+ +LT+      SM +D+I S L  + +  P+  ++   +LE F+  KV ++ L+++   Y L K
Sbjct:  457 DWTPDPTDAVPDK-LGSKRRSSDIISLLVSIYGSKDIFIDEYRGVLADRLLQQLNYNTAREIRNVELLKLRFGESHMHYCEVMLKDMADSRRINGNIREEESRLSEDEQPPLPLSAIILSSEFWPTLKEEKLELPPVVCRAMEAYTHRYEKLKAMRTLSWKPHLGSVILDVELEDRILTNLTVSPIQAAIILHFQDKSSWTLEELSGKLGAPKELVHRKLALWQQQGVLR--EEAG--GRYYVVEMGSSMEKLERGGMLIDSDEERDSNTTTQSEQREEKLQLFWAYIQAMLTNLD----SMTLDRIHSMLRIFVATGPVVTEMDISELEAFLQKKVREQQLLMSAGVYRLPK 800

[Close]

BLAST of Anaphase-promoting complex subunit 2 vs. Ensembl Medaka
Match: cul4b (cullin 4B [Source:NCBI gene;Acc:101161413])

HSP 1 Score: 53.1434 bits (126), Expect = 5.949e-7
Identity = 40/175 (22.86%), Postives = 74/175 (42.29%), Query Frame = 1

Query:  481 KRLDVLSLLLSIYNSRELFASEYKNLLSQRLVKKIDFDVDKELRNLETLKLRFGQDYLQDCDVMLKDIRESRRINNTIQEKFSLSDTVP-EFNIQSYVISAEYWSKMIEKEFQLPEKLKIWFDKYSKHYSDYKRNRELKWYQILGSVEIEVELHNKSLKMDVSPLQATIIYCFSE 1002
            K LD + ++      +++F + YK  L++RL+      VD E   L  LK   G  +    + M KD+  S+     I  +F     +P    +   +++  YW   +  E  LP ++    + +   Y      R+L+W   LG   ++ E      ++ VS  Q  ++  F+E
Sbjct:  535 KMLDKIMIIFRFIYGKDVFEAFYKKDLAKRLLVGKSASVDAEKSMLSKLKHECGAAFTSKLEGMFKDMELSK----DIMVQFKQCQNIPGNIELTVNILTMGYWPTYVPMEVHLPPEMVRLQEIFKTFYLGKHSGRKLQWQSTLGHCVLKAEFKEGKKELQVSLFQTLVLLMFNE 705

[Close]

BLAST of Anaphase-promoting complex subunit 2 vs. Ensembl Medaka
Match: cul4a (cullin-4A [Source:NCBI gene;Acc:101154851])

HSP 1 Score: 51.9878 bits (123), Expect = 1.099e-6
Identity = 43/174 (24.71%), Postives = 76/174 (43.68%), Query Frame = 1

Query:  487 LDVLSLLLSIYNSRELFASEYKNLLSQRLVKKIDFDVDKELRNLETLKLRFGQDYLQDCDVMLKDIRESRRINNTIQEKFSLSDTVPEFNIQSYV--ISAEYWSKMIEKEFQLPEKLKIWFDKYSKHYSDYKRNRELKWYQILGSVEIEVELHNKSLKMDVSPLQATIIYCFSE 1002
            LD + ++    + +++F + YK  L++RL+      VD E   L  LK   G  +    + M KD+  S+ I   IQ K  + +     NI+  V  ++  YW      E  LP ++    + +   Y      R+L+W   LG   ++ E      ++ VS  Q  ++  F+E
Sbjct:  286 LDKIMIIFRFIHGKDVFEAFYKKDLAKRLLVGKSASVDAEKSMLSKLKHECGAAFTSKLEGMFKDMELSKDI--MIQFKQHMQNQSEPSNIELTVNILTMGYWPSYTPMEVHLPAEMVKLQEVFKLFYLGKHSGRKLQWQPTLGHAVLKAEFKEGKKELQVSLFQTLVLLMFNE 457

[Close]

BLAST of Anaphase-promoting complex subunit 2 vs. Ensembl Medaka
Match: ENSORLT00000018731.2 (cullin-5 [Source:NCBI gene;Acc:101154889])

HSP 1 Score: 50.8322 bits (120), Expect = 2.765e-6
Identity = 39/173 (22.54%), Postives = 84/173 (48.55%), Query Frame = 1

Query:  502 LLLSIYNSRELFASEYKNLLSQRLVKKIDFDVDKELRNLETLK-LRFGQDYLQDCDVMLKDIRESRRINNTIQEKFSLSD-TVPEFNIQSYVISAEYWSKMIEKEF-QLPEKLKIWFDKYSKHYSDYKRNRELKWYQILGSVEIEVELHNKSLKMDVSPLQATIIYCFSEKPR 1011
            L+L    ++++F   +K  L++RL+  I  D + E   +E L+ +    DY+     M +DI+ S  +N + +E        +P  ++   +++A  WS+  EK F  LP +L+    +    Y      R+L W+ ++ +  I  +       ++V+  Q  +++ ++++PR
Sbjct:  439 LVLKYVQNKDVFMRYHKAHLTRRLILDISADSEIEENMVEWLREVGMPADYVNKLARMFQDIKVSEDLNQSFKEMHKHKRLALPADSVNIKILNAGAWSRSSEKVFVSLPTELEDLIPEVEDFYKKNHSGRKLHWHHLMSNGIITFKNEVGHYDLEVTTFQLAVLFAWNQRPR 611

[Close]

BLAST of Anaphase-promoting complex subunit 2 vs. Ensembl Medaka
Match: ENSORLT00000033215.1 (cullin-5 [Source:NCBI gene;Acc:101154889])

HSP 1 Score: 50.8322 bits (120), Expect = 3.286e-6
Identity = 39/173 (22.54%), Postives = 84/173 (48.55%), Query Frame = 1

Query:  502 LLLSIYNSRELFASEYKNLLSQRLVKKIDFDVDKELRNLETLK-LRFGQDYLQDCDVMLKDIRESRRINNTIQEKFSLSD-TVPEFNIQSYVISAEYWSKMIEKEF-QLPEKLKIWFDKYSKHYSDYKRNRELKWYQILGSVEIEVELHNKSLKMDVSPLQATIIYCFSEKPR 1011
            L+L    ++++F   +K  L++RL+  I  D + E   +E L+ +    DY+     M +DI+ S  +N + +E        +P  ++   +++A  WS+  EK F  LP +L+    +    Y      R+L W+ ++ +  I  +       ++V+  Q  +++ ++++PR
Sbjct:  418 LVLKYVQNKDVFMRYHKAHLTRRLILDISADSEIEENMVEWLREVGMPADYVNKLARMFQDIKVSEDLNQSFKEMHKHKRLALPADSVNIKILNAGAWSRSSEKVFVSLPTELEDLIPEVEDFYKKNHSGRKLHWHHLMSNGIITFKNEVGHYDLEVTTFQLAVLFAWNQRPR 590

[Close]

BLAST of Anaphase-promoting complex subunit 2 vs. Planmine SMEST
Match: SMESG000022225.1 (SMESG000022225.1)

HSP 1 Score: 629.402 bits (1622), Expect = 0.000e+0
Identity = 355/355 (100.00%), Postives = 355/355 (100.00%), Query Frame = 1

Query:  412 TLREMHDWIPDPIDSVGIRSLWYKRLDVLSLLLSIYNSRELFASEYKNLLSQRLVKKIDFDVDKELRNLETLKLRFGQDYLQDCDVMLKDIRESRRINNTIQEKFSLSDTVPEFNIQSYVISAEYWSKMIEKEFQLPEKLKIWFDKYSKHYSDYKRNRELKWYQILGSVEIEVELHNKSLKMDVSPLQATIIYCFSEKPRWEXXXXXXXXXXXXXXVRRAINFWLQKDFLKRVKEHGILESYEILXXXXXXXXXXXXXXXXXXXXXXXXXXNGETNSKNEMYQNLWMIIKFILTHASTQKQSMDIDKIFSTLPTYTSGDPIKITKEQLEIFMDNKVTQKLLVVNHKNYYLNKSAI 1476
            TLREMHDWIPDPIDSVGIRSLWYKRLDVLSLLLSIYNSRELFASEYKNLLSQRLVKKIDFDVDKELRNLETLKLRFGQDYLQDCDVMLKDIRESRRINNTIQEKFSLSDTVPEFNIQSYVISAEYWSKMIEKEFQLPEKLKIWFDKYSKHYSDYKRNRELKWYQILGSVEIEVELHNKSLKMDVSPLQATIIYCFSEKPRWELAVLAQNLQLNLSVVRRAINFWLQKDFLKRVKEHGILESYEILDNEEGEIIDDKKKMIDVDIDGDSDEDNGETNSKNEMYQNLWMIIKFILTHASTQKQSMDIDKIFSTLPTYTSGDPIKITKEQLEIFMDNKVTQKLLVVNHKNYYLNKSAI
Sbjct:  322 TLREMHDWIPDPIDSVGIRSLWYKRLDVLSLLLSIYNSRELFASEYKNLLSQRLVKKIDFDVDKELRNLETLKLRFGQDYLQDCDVMLKDIRESRRINNTIQEKFSLSDTVPEFNIQSYVISAEYWSKMIEKEFQLPEKLKIWFDKYSKHYSDYKRNRELKWYQILGSVEIEVELHNKSLKMDVSPLQATIIYCFSEKPRWELAVLAQNLQLNLSVVRRAINFWLQKDFLKRVKEHGILESYEILDNEEGEIIDDKKKMIDVDIDGDSDEDNGETNSKNEMYQNLWMIIKFILTHASTQKQSMDIDKIFSTLPTYTSGDPIKITKEQLEIFMDNKVTQKLLVVNHKNYYLNKSAI 676

[Close]

BLAST of Anaphase-promoting complex subunit 2 vs. Planmine SMEST
Match: SMESG000022225.1 (SMESG000022225.1)

HSP 1 Score: 619.772 bits (1597), Expect = 0.000e+0
Identity = 351/351 (100.00%), Postives = 351/351 (100.00%), Query Frame = 1

Query:  424 MHDWIPDPIDSVGIRSLWYKRLDVLSLLLSIYNSRELFASEYKNLLSQRLVKKIDFDVDKELRNLETLKLRFGQDYLQDCDVMLKDIRESRRINNTIQEKFSLSDTVPEFNIQSYVISAEYWSKMIEKEFQLPEKLKIWFDKYSKHYSDYKRNRELKWYQILGSVEIEVELHNKSLKMDVSPLQATIIYCFSEKPRWEXXXXXXXXXXXXXXVRRAINFWLQKDFLKRVKEHGILESYEILXXXXXXXXXXXXXXXXXXXXXXXXXXNGETNSKNEMYQNLWMIIKFILTHASTQKQSMDIDKIFSTLPTYTSGDPIKITKEQLEIFMDNKVTQKLLVVNHKNYYLNKSAI 1476
            MHDWIPDPIDSVGIRSLWYKRLDVLSLLLSIYNSRELFASEYKNLLSQRLVKKIDFDVDKELRNLETLKLRFGQDYLQDCDVMLKDIRESRRINNTIQEKFSLSDTVPEFNIQSYVISAEYWSKMIEKEFQLPEKLKIWFDKYSKHYSDYKRNRELKWYQILGSVEIEVELHNKSLKMDVSPLQATIIYCFSEKPRWELAVLAQNLQLNLSVVRRAINFWLQKDFLKRVKEHGILESYEILDNEEGEIIDDKKKMIDVDIDGDSDEDNGETNSKNEMYQNLWMIIKFILTHASTQKQSMDIDKIFSTLPTYTSGDPIKITKEQLEIFMDNKVTQKLLVVNHKNYYLNKSAI
Sbjct:    1 MHDWIPDPIDSVGIRSLWYKRLDVLSLLLSIYNSRELFASEYKNLLSQRLVKKIDFDVDKELRNLETLKLRFGQDYLQDCDVMLKDIRESRRINNTIQEKFSLSDTVPEFNIQSYVISAEYWSKMIEKEFQLPEKLKIWFDKYSKHYSDYKRNRELKWYQILGSVEIEVELHNKSLKMDVSPLQATIIYCFSEKPRWELAVLAQNLQLNLSVVRRAINFWLQKDFLKRVKEHGILESYEILDNEEGEIIDDKKKMIDVDIDGDSDEDNGETNSKNEMYQNLWMIIKFILTHASTQKQSMDIDKIFSTLPTYTSGDPIKITKEQLEIFMDNKVTQKLLVVNHKNYYLNKSAI 351

[Close]

BLAST of Anaphase-promoting complex subunit 2 vs. Planmine SMEST
Match: SMESG000022225.1 (SMESG000022225.1)

HSP 1 Score: 474.167 bits (1219), Expect = 1.806e-166
Identity = 279/279 (100.00%), Postives = 279/279 (100.00%), Query Frame = 1

Query:  424 MHDWIPDPIDSVGIRSLWYKRLDVLSLLLSIYNSRELFASEYKNLLSQRLVKKIDFDVDKELRNLETLKLRFGQDYLQDCDVMLKDIRESRRINNTIQEKFSLSDTVPEFNIQSYVISAEYWSKMIEKEFQLPEKLKIWFDKYSKHYSDYKRNRELKWYQILGSVEIEVELHNKSLKMDVSPLQATIIYCFSEKPRWEXXXXXXXXXXXXXXVRRAINFWLQKDFLKRVKEHGILESYEILXXXXXXXXXXXXXXXXXXXXXXXXXXNGETNSKNEMYQ 1260
            MHDWIPDPIDSVGIRSLWYKRLDVLSLLLSIYNSRELFASEYKNLLSQRLVKKIDFDVDKELRNLETLKLRFGQDYLQDCDVMLKDIRESRRINNTIQEKFSLSDTVPEFNIQSYVISAEYWSKMIEKEFQLPEKLKIWFDKYSKHYSDYKRNRELKWYQILGSVEIEVELHNKSLKMDVSPLQATIIYCFSEKPRWELAVLAQNLQLNLSVVRRAINFWLQKDFLKRVKEHGILESYEILDNEEGEIIDDKKKMIDVDIDGDSDEDNGETNSKNEMYQ
Sbjct:    1 MHDWIPDPIDSVGIRSLWYKRLDVLSLLLSIYNSRELFASEYKNLLSQRLVKKIDFDVDKELRNLETLKLRFGQDYLQDCDVMLKDIRESRRINNTIQEKFSLSDTVPEFNIQSYVISAEYWSKMIEKEFQLPEKLKIWFDKYSKHYSDYKRNRELKWYQILGSVEIEVELHNKSLKMDVSPLQATIIYCFSEKPRWELAVLAQNLQLNLSVVRRAINFWLQKDFLKRVKEHGILESYEILDNEEGEIIDDKKKMIDVDIDGDSDEDNGETNSKNEMYQ 279

[Close]

BLAST of Anaphase-promoting complex subunit 2 vs. Planmine SMEST
Match: SMESG000048530.1 (SMESG000048530.1)

HSP 1 Score: 454.907 bits (1169), Expect = 7.960e-160
Identity = 269/269 (100.00%), Postives = 269/269 (100.00%), Query Frame = 1

Query:  670 MLKDIRESRRINNTIQEKFSLSDTVPEFNIQSYVISAEYWSKMIEKEFQLPEKLKIWFDKYSKHYSDYKRNRELKWYQILGSVEIEVELHNKSLKMDVSPLQATIIYCFSEKPRWEXXXXXXXXXXXXXXVRRAINFWLQKDFLKRVKEHGILESYEILXXXXXXXXXXXXXXXXXXXXXXXXXXNGETNSKNEMYQNLWMIIKFILTHASTQKQSMDIDKIFSTLPTYTSGDPIKITKEQLEIFMDNKVTQKLLVVNHKNYYLNKSAI 1476
            MLKDIRESRRINNTIQEKFSLSDTVPEFNIQSYVISAEYWSKMIEKEFQLPEKLKIWFDKYSKHYSDYKRNRELKWYQILGSVEIEVELHNKSLKMDVSPLQATIIYCFSEKPRWELAVLAQNLQLNLSVVRRAINFWLQKDFLKRVKEHGILESYEILDNEEGEIIDDKKKMIDVDIDGDSDEDNGETNSKNEMYQNLWMIIKFILTHASTQKQSMDIDKIFSTLPTYTSGDPIKITKEQLEIFMDNKVTQKLLVVNHKNYYLNKSAI
Sbjct:    1 MLKDIRESRRINNTIQEKFSLSDTVPEFNIQSYVISAEYWSKMIEKEFQLPEKLKIWFDKYSKHYSDYKRNRELKWYQILGSVEIEVELHNKSLKMDVSPLQATIIYCFSEKPRWELAVLAQNLQLNLSVVRRAINFWLQKDFLKRVKEHGILESYEILDNEEGEIIDDKKKMIDVDIDGDSDEDNGETNSKNEMYQNLWMIIKFILTHASTQKQSMDIDKIFSTLPTYTSGDPIKITKEQLEIFMDNKVTQKLLVVNHKNYYLNKSAI 269

[Close]

BLAST of Anaphase-promoting complex subunit 2 vs. Planmine SMEST
Match: SMESG000048530.1 (SMESG000048530.1)

HSP 1 Score: 315.079 bits (806), Expect = 4.080e-101
Identity = 199/199 (100.00%), Postives = 199/199 (100.00%), Query Frame = 1

Query:  664 DVMLKDIRESRRINNTIQEKFSLSDTVPEFNIQSYVISAEYWSKMIEKEFQLPEKLKIWFDKYSKHYSDYKRNRELKWYQILGSVEIEVELHNKSLKMDVSPLQATIIYCFSEKPRWEXXXXXXXXXXXXXXVRRAINFWLQKDFLKRVKEHGILESYEILXXXXXXXXXXXXXXXXXXXXXXXXXXNGETNSKNEMYQ 1260
            DVMLKDIRESRRINNTIQEKFSLSDTVPEFNIQSYVISAEYWSKMIEKEFQLPEKLKIWFDKYSKHYSDYKRNRELKWYQILGSVEIEVELHNKSLKMDVSPLQATIIYCFSEKPRWELAVLAQNLQLNLSVVRRAINFWLQKDFLKRVKEHGILESYEILDNEEGEIIDDKKKMIDVDIDGDSDEDNGETNSKNEMYQ
Sbjct:  309 DVMLKDIRESRRINNTIQEKFSLSDTVPEFNIQSYVISAEYWSKMIEKEFQLPEKLKIWFDKYSKHYSDYKRNRELKWYQILGSVEIEVELHNKSLKMDVSPLQATIIYCFSEKPRWELAVLAQNLQLNLSVVRRAINFWLQKDFLKRVKEHGILESYEILDNEEGEIIDDKKKMIDVDIDGDSDEDNGETNSKNEMYQ 507

The following BLAST results are available for this feature:

BLAST of Anaphase-promoting complex subunit 2 vs. Ensembl Human
BLAST of Anaphase-promoting complex subunit 2 vs. Ensembl Celegans
BLAST of Anaphase-promoting complex subunit 2 vs. Ensembl Fly
BLAST of Anaphase-promoting complex subunit 2 vs. Ensembl Zebrafish
BLAST of Anaphase-promoting complex subunit 2 vs. Ensembl Xenopus
BLAST of Anaphase-promoting complex subunit 2 vs. Ensembl Mouse
BLAST of Anaphase-promoting complex subunit 2 vs. UniProt/SwissProt
BLAST of Anaphase-promoting complex subunit 2 vs. TrEMBL
BLAST of Anaphase-promoting complex subunit 2 vs. Ensembl Cavefish
BLAST of Anaphase-promoting complex subunit 2 vs. Ensembl Sea Lamprey
BLAST of Anaphase-promoting complex subunit 2 vs. Ensembl Yeast
BLAST of Anaphase-promoting complex subunit 2 vs. Ensembl Nematostella
BLAST of Anaphase-promoting complex subunit 2 vs. Ensembl Medaka
BLAST of Anaphase-promoting complex subunit 2 vs. Planmine SMEST

BLAST of Anaphase-promoting complex subunit 2 vs. Ensembl Human
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Human e!99)
Total hits: 5


Match Name	E-value	Identity	Description
ANAPC2	1.851e-46	31.18	anaphase promoting complex subunit 2 [Source:HGNC ...	[more]
CUL4B	1.361e-6	21.84	cullin 4B [Source:HGNC Symbol;Acc:HGNC:2555]	[more]
CUL4B	1.366e-6	23.86	cullin 4B [Source:HGNC Symbol;Acc:HGNC:2555]	[more]
CUL4B	1.708e-6	21.84	cullin 4B [Source:HGNC Symbol;Acc:HGNC:2555]	[more]
CUL4B	1.864e-6	21.84	cullin 4B [Source:HGNC Symbol;Acc:HGNC:2555]	[more]

BLAST of Anaphase-promoting complex subunit 2 vs. Ensembl Celegans
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99)
Total hits: 1


Match Name	E-value	Identity	Description
apc-2	7.616e-29	32.61	Anaphase-promoting complex subunit 2 [Source:UniP...	[more]

BLAST of Anaphase-promoting complex subunit 2 vs. Ensembl Fly
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99)
Total hits: 4


Match Name	E-value	Identity	Description
mr	2.725e-50	32.49	gene:FBgn0002791 transcript:FBtr0072156	[more]
Cul4	1.680e-9	24.86	gene:FBgn0033260 transcript:FBtr0301355	[more]
Cul4	1.680e-9	24.86	gene:FBgn0033260 transcript:FBtr0088821	[more]
Cul5	8.194e-6	24.14	gene:FBgn0039632 transcript:FBtr0085417	[more]

BLAST of Anaphase-promoting complex subunit 2 vs. Ensembl Zebrafish
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99)
Total hits: 5


Match Name	E-value	Identity	Description
anapc2	2.514e-46	30.68	anaphase promoting complex subunit 2 [Source:ZFIN;...	[more]
cul4b	2.059e-7	21.84	cullin 4B [Source:ZFIN;Acc:ZDB-GENE-041008-208]	[more]
cul4b	2.377e-7	21.84	cullin 4B [Source:ZFIN;Acc:ZDB-GENE-041008-208]	[more]
BX324225.3	1.186e-6	22.54	cullin 5b [Source:NCBI gene;Acc:100006147]	[more]
cul5b	1.749e-6	22.54	cullin 5b [Source:ZFIN;Acc:ZDB-GENE-091113-45]	[more]

BLAST of Anaphase-promoting complex subunit 2 vs. Ensembl Xenopus
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99)
Total hits: 5


Match Name	E-value	Identity	Description
lhx6	7.092e-18	47.13	LIM homeobox 6 [Source:Xenbase;Acc:XB-GENE-493341]	[more]
dnlz	5.485e-7	21.84	DNL-type zinc finger [Source:Xenbase;Acc:XB-GENE-9...	[more]
dnlz	5.622e-7	21.84	DNL-type zinc finger [Source:Xenbase;Acc:XB-GENE-9...	[more]
dnlz	5.693e-7	21.84	DNL-type zinc finger [Source:Xenbase;Acc:XB-GENE-9...	[more]
dnlz	6.839e-7	21.84	DNL-type zinc finger [Source:Xenbase;Acc:XB-GENE-9...	[more]

BLAST of Anaphase-promoting complex subunit 2 vs. Ensembl Mouse
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99)
Total hits: 5


Match Name	E-value	Identity	Description
Anapc2	1.585e-44	30.90	anaphase promoting complex subunit 2 [Source:MGI S...	[more]
Cul2	5.528e-7	22.60	cullin 2 [Source:MGI Symbol;Acc:MGI:1918995]	[more]
Cul2	6.295e-7	22.60	cullin 2 [Source:MGI Symbol;Acc:MGI:1918995]	[more]
Cul2	8.181e-7	22.60	cullin 2 [Source:MGI Symbol;Acc:MGI:1918995]	[more]
Cul4a	9.213e-7	21.51	cullin 4A [Source:MGI Symbol;Acc:MGI:1914487]	[more]

BLAST of Anaphase-promoting complex subunit 2 vs. UniProt/SwissProt
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt)
Total hits: 5


Match Name	E-value	Identity	Description
sp\|Q9UJX6\|ANC2_HUMAN	8.888e-46	31.18	Anaphase-promoting complex subunit 2 OS=Homo sapie...	[more]
sp\|Q8BZQ7\|ANC2_MOUSE	1.109e-43	30.90	Anaphase-promoting complex subunit 2 OS=Mus muscul...	[more]
sp\|Q8H1U5\|APC2_ARATH	2.193e-34	27.32	Anaphase-promoting complex subunit 2 OS=Arabidopsi...	[more]
sp\|P34514\|ANC2_CAEEL	9.688e-28	32.61	Anaphase-promoting complex subunit 2 OS=Caenorhabd...	[more]
sp\|Q551S9\|APC2_DICDI	4.743e-27	33.97	Anaphase-promoting complex subunit 2 OS=Dictyostel...	[more]

BLAST of Anaphase-promoting complex subunit 2 vs. TrEMBL
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL)
Total hits: 5


Match Name	E-value	Identity	Description
B3S490	2.645e-50	33.99	CULLIN_2 domain-containing protein (Fragment) OS=T...	[more]
A0A1B0D9E0	1.042e-49	34.97	CULLIN_2 domain-containing protein OS=Phlebotomus ...	[more]
Q95TK2	2.693e-49	32.95	LD45730p OS=Drosophila melanogaster OX=7227 GN=mr ...	[more]
B4LP09	7.753e-49	34.70	Uncharacterized protein, isoform A OS=Drosophila v...	[more]
A0A084WCU6	1.195e-48	33.14	AGAP005048-PA-like protein OS=Anopheles sinensis O...	[more]

BLAST of Anaphase-promoting complex subunit 2 vs. Ensembl Cavefish
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99)
Total hits: 5


Match Name	E-value	Identity	Description
anapc2	3.630e-46	30.17	anaphase promoting complex subunit 2 [Source:NCBI ...	[more]
ENSAMXT00000057183.1	2.447e-7	21.84	pep primary_assembly:Astyanax_mexicanus-2.0:APWO02...	[more]
cul4b	1.107e-6	21.84	cullin 4B [Source:ZFIN;Acc:ZDB-GENE-041008-208]	[more]
cul4a	1.206e-6	24.71	cullin 4A [Source:ZFIN;Acc:ZDB-GENE-040426-1357]	[more]
cul5a	8.393e-6	22.29	cullin 5 [Source:NCBI gene;Acc:103032672]	[more]

BLAST of Anaphase-promoting complex subunit 2 vs. Ensembl Sea Lamprey
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99)
Total hits: 2


Match Name	E-value	Identity	Description
cul4b	5.398e-7	21.51	cullin 4B [Source:ZFIN;Acc:ZDB-GENE-041008-208]	[more]
cul2	9.173e-6	21.95	cullin 2 [Source:ZFIN;Acc:ZDB-GENE-030131-8032]	[more]

BLAST of Anaphase-promoting complex subunit 2 vs. Ensembl Yeast
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46)
Total hits: 1


Match Name	E-value	Identity	Description
APC2	9.012e-11	27.27	Subunit of the Anaphase-Promoting Complex/Cyclosom...	[more]

BLAST of Anaphase-promoting complex subunit 2 vs. Ensembl Nematostella
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46)
Total hits: 3


Match Name	E-value	Identity	Description
EDO33056	6.551e-48	31.73	Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7...	[more]
EDO38761	4.114e-7	23.46	Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7...	[more]
EDO35660	3.678e-6	19.77	Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7...	[more]

BLAST of Anaphase-promoting complex subunit 2 vs. Ensembl Medaka
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99)
Total hits: 5


Match Name	E-value	Identity	Description
anapc2	9.602e-47	32.86	anaphase promoting complex subunit 2 [Source:NCBI ...	[more]
cul4b	5.949e-7	22.86	cullin 4B [Source:NCBI gene;Acc:101161413]	[more]
cul4a	1.099e-6	24.71	cullin-4A [Source:NCBI gene;Acc:101154851]	[more]
ENSORLT00000018731.2	2.765e-6	22.54	cullin-5 [Source:NCBI gene;Acc:101154889]	[more]
ENSORLT00000033215.1	3.286e-6	22.54	cullin-5 [Source:NCBI gene;Acc:101154889]	[more]

BLAST of Anaphase-promoting complex subunit 2 vs. Planmine SMEST
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST)
Total hits: 5


Match Name	E-value	Identity	Description
SMESG000022225.1	0.000e+0	100.00	SMESG000022225.1	[more]
SMESG000022225.1	0.000e+0	100.00	SMESG000022225.1	[more]
SMESG000022225.1	1.806e-166	100.00	SMESG000022225.1	[more]
SMESG000048530.1	7.960e-160	100.00	SMESG000048530.1	[more]
SMESG000048530.1	4.080e-101	100.00	SMESG000048530.1	[more]

Analyses

This transcript is derived from or has results from the following analyses


Analysis Name	Date Performed
Embryonic Stages	2016-07-25
Schmidtea mediterranea smed_20140614 BLASTX Human e!99	2016-08-08
Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99	2016-08-08
Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL	2020-05-01
Schmidtea mediterranea Sexual smed_20140614 transcriptome	2016-07-25
Schmidtea mediteranean smed_20140614 Interproscan	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST	2020-05-08

Sequences

The following sequences are available for this feature:

transcript sequence
protein sequence

transcript sequence

>SMED30011868 ID=SMED30011868|Name=Anaphase-promoting complex subunit 2|organism=Schmidtea mediterranea sexual|type=transcript|length=1516bp
CGATCTGAAAGGGTTAATATAAGAGGAAAATGTGGAAAACAAACAAACCT
ATTAAGAGTTTTATTATAAATATCATAAATAAACTGCTGATAAATTGTCA
ATGGACTTTATAATTTAAATATTATATATAATATTACATAATGTAGTGAA
CAAACATTTTAAAAGCTTTATATCACCAAACTGATCTTTTCAATTTTTCT
AAACATTTTCCACTTTGCTAAAATCAGAAATCCATGTGAAACTTGTTGAA
ACACATTGTTCCAATTCGATATCGAATTTCCCATAAGCTAATGTTTTTAG
ATTATCTTACTTTATATTCTGCATTATTTATCAATGGATATTAAAATTAT
AGTAAATTAATGTTAATTGGTGCCCTGCTACTAAAGGTGAAATTGGTTTA
AACGGTTAGGTACACTGAGAGAGATGCATGACTGGATTCCCGATCCAATC
GATTCAGTCGGAATTCGAAGTTTGTGGTACAAACGGCTGGATGTATTGAG
CCTTCTGCTTAGTATCTATAACAGTCGGGAATTATTTGCATCTGAATATA
AAAACCTGCTGAGTCAGAGATTGGTGAAAAAAATTGATTTCGATGTGGAC
AAAGAACTTAGAAATTTAGAAACATTAAAATTGAGATTTGGACAAGACTA
TCTTCAAGATTGTGATGTAATGCTGAAAGATATTAGGGAATCTAGAAGAA
TCAATAATACTATACAAGAGAAATTCTCATTGTCTGACACAGTACCGGAA
TTCAATATTCAATCCTATGTCATATCTGCCGAATATTGGTCGAAAATGAT
TGAAAAAGAGTTTCAGTTGCCAGAAAAATTAAAGATATGGTTTGATAAAT
ACTCCAAACACTATAGTGACTATAAACGCAACCGTGAATTGAAATGGTAT
CAAATTCTTGGTTCAGTAGAAATTGAAGTGGAGTTGCACAATAAATCCCT
GAAAATGGATGTATCACCATTGCAGGCGACAATAATTTACTGCTTTTCTG
AGAAACCTCGTTGGGAACTTGCAGTTTTAGCTCAAAATCTTCAACTCAAT
CTGTCGGTTGTAAGACGGGCAATAAACTTTTGGCTTCAAAAGGACTTTCT
GAAACGTGTCAAAGAACACGGGATTCTGGAATCGTATGAAATACTCGATA
ATGAAGAAGGAGAAATAATTGATGACAAGAAAAAAATGATTGATGTTGAC
ATTGATGGAGATTCAGATGAGGATAACGGAGAAACAAATTCCAAAAATGA
AATGTATCAAAATCTGTGGATGATCATCAAATTTATTCTCACTCACGCAT
CGACACAAAAACAATCTATGGATATTGATAAAATATTCTCAACCTTGCCT
ACATACACAAGTGGAGATCCGATTAAAATTACCAAAGAGCAATTGGAAAT
ATTCATGGACAACAAGGTCACCCAGAAATTGCTTGTTGTAAACCACAAAA
ATTACTACCTAAACAAGAGCGCGATTTGAAATTTTGTGAATGAAATAAAT
TTATTATTTAATGTTG

protein sequence of SMED30011868-orf-1

>SMED30011868-orf-1 ID=SMED30011868-orf-1|Name=SMED30011868-orf-1|organism=Schmidtea mediterranea sexual|type=polypeptide|length=352bp
MHDWIPDPIDSVGIRSLWYKRLDVLSLLLSIYNSRELFASEYKNLLSQRL
VKKIDFDVDKELRNLETLKLRFGQDYLQDCDVMLKDIRESRRINNTIQEK
FSLSDTVPEFNIQSYVISAEYWSKMIEKEFQLPEKLKIWFDKYSKHYSDY
KRNRELKWYQILGSVEIEVELHNKSLKMDVSPLQATIIYCFSEKPRWELA
VLAQNLQLNLSVVRRAINFWLQKDFLKRVKEHGILESYEILDNEEGEIID
DKKKMIDVDIDGDSDEDNGETNSKNEMYQNLWMIIKFILTHASTQKQSMD
IDKIFSTLPTYTSGDPIKITKEQLEIFMDNKVTQKLLVVNHKNYYLNKSA
I*

Annotated Terms

The following terms have been associated with this transcript:

Vocabulary: **Planarian Anatomy**
Term	Definition
PLANA:0000429	neoblast
PLANA:0002109	X1 cell

Vocabulary: **INTERPRO**
Term	Definition
IPR036388	WH-like_DNA-bd_sf
IPR036317	Cullin_homology_sf
IPR016158	Cullin_homology
IPR001373	Cullin_N
IPR014786	APC_su2_C
IPR011991	WHTH_DNA-bd_dom

Vocabulary: **biological process**
Term	Definition
GO:0006511	ubiquitin-dependent protein catabolic process

Vocabulary: **molecular function**
Term	Definition
GO:0031625	ubiquitin protein ligase binding

InterPro

Analysis Name: Schmidtea mediteranean smed_20140614 Interproscan
Date Performed: 2020-05-01


IPR Term	IPR Description	Source	Source Term	Source Description	Alignment
IPR016158	Cullin homology domain	SMART	SM00182	cul_2	coord: 23..171 e-value: 4.3E-11 score: 52.8
IPR016158	Cullin homology domain	PROSITE	PS50069	CULLIN_2	coord: 20..221 score: 26.458
IPR036388	Winged helix-like DNA-binding domain superfamily	GENE3D	G3DSA:1.10.10.10		coord: 262..350 e-value: 1.5E-6 score: 30.1
None	No IPR available	GENE3D	G3DSA:1.20.1310.10		coord: 16..104 e-value: 2.9E-9 score: 39.0
None	No IPR available	GENE3D	G3DSA:1.10.10.2620		coord: 109..261 e-value: 7.9E-16 score: 60.1
None	No IPR available	PANTHER	PTHR45957	FAMILY NOT NAMED	coord: 3..348
IPR001373	Cullin, N-terminal	PFAM	PF00888	Cullin	coord: 21..217 e-value: 1.7E-26 score: 93.0
IPR014786	Anaphase-promoting complex subunit 2, C-terminal	PFAM	PF08672	ANAPC2	coord: 295..346 e-value: 3.0E-5 score: 24.5
IPR036317	Cullin homology domain superfamily	SUPERFAMILY	SSF75632	Cullin homology domain	coord: 2..233