3-hydroxy-3-methylglutaryl coenzyme A synthase

Overview


Name	3-hydroxy-3-methylglutaryl coenzyme A synthase
Smed ID	SMED30011849
Length (bp)	1632

Neoblast Clusters

▻ Sub-lethal Irradiated Surviving X1 and X2 Cell Population

Overview

Single cell RNA-seq of pluripotent neoblasts and its early progenies

We isolated X1 neoblasts cells enriched in high piwi-1 expression (Neoblast Population), and profiled ∼7,614 individual cells via scRNA-seq. Unsupervised analyses uncovered 12 distinct classes from 7,088 high-quality cells. We designated these classes Nb1 to Nb12 and ordered them based on high (Nb1) to low (Nb12) piwi-1 expression levels. We further defined groups of genes that best classified the cells parsed into 12 distinct cell clusters to generate a scaled expression heat map of discriminative gene sets for each cluster. Expression of each cluster’s gene signatures was validated using multiplex fluorescence in situ hybridization (FISH) co-stained with piwi-1 and largely confirmed the cell clusters revealed by scRNA-seq.

We also tested sub-lethal irradiation exposure. To profile rare pluripotent stem cells (PSCs) and avoid interference from immediate progenitor cells, we determined a time point after sub-lethal irradiation (7 DPI) with minimal piwi-1+ cells, followed by isolation and single-cell RNA-seq of 1,200 individual cells derived from X1 (Piwi-1 high) and X2 (Piwi-1 low) cell populations (Sub-lethal Irradiated Surviving X1 and X2 Cell Population)

Explore this single cell expression dataset with our NB Cluster Shiny App

Neoblast Population

t-SNE plot shows two-dimensional representation of global gene expression relationships among all neoblasts (n = 7,088 after filter). Cluster identity was assigned based on the top 10 marker genes of each cluster (Table S2), followed by inspection of RNA in situ hybridization patterns. Neoblast groups, Nb.

Expression of 3-hydroxy-3-methylglutaryl coenzyme A synthase (SMED30011849) t-SNE clustered cells

Violin plots show distribution of expression levels for 3-hydroxy-3-methylglutaryl coenzyme A synthase (SMED30011849) in cells (dots) of each of the 12 neoblast clusters.

Sub-lethal Irradiated Surviving X1 and X2 Cell Population

t-SNE plot of surviving X1 and X2 cells (n = 1,039 after QC filter) after sub-lethal irradiation. Colors indicate unbiased cell classification via graph-based clustering. SL, sub-lethal irradiated cell groups.

Expression of 3-hydroxy-3-methylglutaryl coenzyme A synthase (SMED30011849) in the t-SNE clustered sub-lethally irradiated X1 and X2 cells.

Embryonic Expression

Davies et. al., 2017

Hover the mouse over a column in the graph to view average RPKM values per sample.
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Embryonic Stages: Y: yolk. S2-S8: Stages 2-8. C4: asexual adult. SX: virgin, sexually mature adult.
For further information about sample preparation and analysis for the single animal RNA-Seq experiment, please refer to the Materials and Methods

Anatomical Expression

PAGE et. al., 2020

SMED30011849

has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGE

PAGE Curations: 5

Expressed In	Reference Transcript	Gene Models	Published Transcript	Transcriptome	Publication
epidermis	SMED30011849	h1SMcG0006262	dd_Smed_v4_2847_0_1	dd_Smed_v4	PMID:29674431 Fincher et al., 2018
cephalic ganglia	SMED30011849	h1SMcG0006262	dd_Smed_v4_2847_0_1	dd_Smed_v4	PMID:29674431 Fincher et al., 2018
epidermis	SMED30011849	h1SMcG0006262	dd_Smed_v4_2847_0_1	dd_Smed_v4	PMID:28292427 Wurtzel et al., 2017
dorsal region of the epidermis	SMED30011849	h1SMcG0006262	dd_Smed_v4_2847_0_1	dd_Smed_v4	PMID:28292427 Wurtzel et al., 2017
ciliated epithelial cell	SMED30011849	h1SMcG0006262	dd_Smed_v4_2847_0_1	dd_Smed_v4	PMID:28292427 Wurtzel et al., 2017

Note: Hover over icons to view figure legend

Homology

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BLAST of 3-hydroxy-3-methylglutaryl coenzyme A synthase vs. Ensembl Human
Match: HMGCS2 (3-hydroxy-3-methylglutaryl-CoA synthase 2 [Source:HGNC Symbol;Acc:HGNC:5008])

HSP 1 Score: 391.734 bits (1005), Expect = 1.510e-130
Identity = 214/454 (47.14%), Postives = 297/454 (65.42%), Query Frame = 1

Query:   10 DIGIKAVEIYFPNTCIDQKDLEESDNC-LGKYTVGLGQIKMGVCSDLEDINSIALTVTKQLLENNFIDPNDIGFLSVGTETLIDKSKSTKTVLMELFEKHGNTDIQGVDEKNACFGGTASLFAALDWLESSNCDGRLXXXXXXXXXXXXXXXXRCTGGAGAVAMLLGPNAPLIFDKGIRSHHMSHQWDFYKPKLDSEYPVYDGQLSIISYQKSIDKCFQLYKKKCLNKGLINQSMILFREN--YYFCFHSPYTKLVEKSFARLVFND-IKDNPDIVEQFNEQLEDIKPFLHLNIENTYGNRDFDLSFLKFSDTLIKDKLRPGVLMAQNNGNMYTASLYGSLISVLIQTPIEELVGSRIVLFSYGSGLASCMFSLMITENKM---KLSEIKDSLNKIVDNLKNRIILSYKEFEDFLARRSSINCKCNVKPSTELSYLRSGTFYLSEIDEKYRRKY 1350
            D+GI A+E+YFP   +DQ DLE+ +N   GKYTVGLGQ +MG CS  EDINS+ LTV ++L+E   +  + +G L VGTET+IDKSK+ KTVLMELF+  GNTDI+G+D  NAC+GGTASLF A +W+ESS+ DGR A+VV  DIA+Y    AR TGGAGAVAML+GP APL  ++G+R  HM + +DFYKP L SEYP+ DG+LSI  Y +++D+C+  Y+KK  N+     S   F  +   Y  FH+P+ K+V+KS ARL+FND +  + D      + LE    F  L +E+TY N+D D + LK S  +   K +  + ++ +NGNMYT+SLYG L S+L     +EL GSRI  FSYGSGLA+  FS  ++++      L ++  S + +   L +R  +S +EF + + +R     K N  P  + + L  GT+YL  +DE++RRKY
Sbjct:   53 DVGILALEVYFPAQYVDQTDLEKYNNVEAGKYTVGLGQTRMGFCSVQEDINSLCLTVVQRLMERIQLPWDSVGRLEVGTETIIDKSKAVKTVLMELFQDSGNTDIEGIDTTNACYGGTASLFNAANWMESSSWDGRYAMVVCGDIAVYPSGNARPTGGAGAVAMLIGPKAPLALERGLRGTHMENVYDFYKPNLASEYPIVDGKLSIQCYLRALDRCYTSYRKKIQNQWKQAGSDRPFTLDDLQYMIFHTPFCKMVQKSLARLMFNDFLSASSDTQTSLYKGLE---AFGGLKLEDTYTNKDLDKALLKASQDMFDKKTKASLYLSTHNGNMYTSSLYGCLASLLSHHSAQELAGSRIGAFSYGSGLAASFFSFRVSQDAAPGSPLDKLVSSTSDLPKRLASRKCVSPEEFTEIMNQREQFYHKVNFSPPGDTNSLFPGTWYLERVDEQHRRKY 503

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BLAST of 3-hydroxy-3-methylglutaryl coenzyme A synthase vs. Ensembl Human
Match: HMGCS1 (3-hydroxy-3-methylglutaryl-CoA synthase 1 [Source:HGNC Symbol;Acc:HGNC:5007])

HSP 1 Score: 387.111 bits (993), Expect = 1.150e-128
Identity = 212/453 (46.80%), Postives = 299/453 (66.00%), Query Frame = 1

Query:   10 DIGIKAVEIYFPNTCIDQKDLEESDNC-LGKYTVGLGQIKMGVCSDLEDINSIALTVTKQLLENNFIDPNDIGFLSVGTETLIDKSKSTKTVLMELFEKHGNTDIQGVDEKNACFGGTASLFAALDWLESSNCDGRLXXXXXXXXXXXXXXXXRCTGGAGAVAMLLGPNAPLIFDKGIRSHHMSHQWDFYKPKLDSEYPVYDGQLSIISYQKSIDKCFQLYKKKCLNKGLI--NQSMILFRENYYFCFHSPYTKLVEKSFARLVFNDIKDNPDIVEQFNEQLEDIKPFLHLNIENTYGNRDFDLSFLKFSDTLIKDKLRPGVLMAQNNGNMYTASLYGSLISVLIQTPIEELVGSRIVLFSYGSGLASCMFSLMITENKM---KLSEIKDSLNKIVDNLKNRIILSYKEFEDFLARRSSINCKCNVKPSTELSYLRSGTFYLSEIDEKYRRKY 1350
            D+GI A+EIYFP+  +DQ +LE+ D    GKYT+GLGQ KMG C+D EDINS+ +TV + L+E N +  + IG L VGTET+IDKSKS KT LM+LFE+ GNTDI+G+D  NAC+GGTA++F A++W+ESS+ DGR A+VVA DIA+YA   AR TGG GAVA+L+GPNAPLIF++G+R  HM H +DFYKP + SEYP+ DG+LSI  Y  ++D+C+ +Y KK   +     N       +  +  FHSPY KLV+KS AR++ ND  ++ +     N     ++ F  + +E+TY +RD + +F+K S  L   K +  +L++  NGNMYT+S+YGSL SVL Q   ++L G RI +FSYGSGLA+ ++SL +T++      L +I  SL  +   L +R  ++   F + +  R   +   N  P   +  L  GT+YL  +DEK+RR Y
Sbjct:   16 DVGIVALEIYFPSQYVDQAELEKYDGVDAGKYTIGLGQAKMGFCTDREDINSLCMTVVQNLMERNNLSYDCIGRLEVGTETIIDKSKSVKTNLMQLFEESGNTDIEGIDTTNACYGGTAAVFNAVNWIESSSWDGRYALVVAGDIAVYATGNARPTGGVGAVALLIGPNAPLIFERGLRGTHMQHAYDFYKPDMLSEYPIVDGKLSIQCYLSALDRCYSVYCKKIHAQWQKEGNDKDFTLNDFGFMIFHSPYCKLVQKSLARMLLNDFLNDQN--RDKNSIYSGLEAFGDVKLEDTYFDRDVEKAFMKASSELFSQKTKASLLVSNQNGNMYTSSVYGSLASVLAQYSPQQLAGKRIGVFSYGSGLAATLYSLKVTQDATPGSALDKITASLCDLKSRLDSRTGVAPDVFAENMKLREDTHHLVNYIPQGSIDSLFEGTWYLVRVDEKHRRTY 466

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Query:   10 DIGIKAVEIYFPNTCIDQKDLEESDNC-LGKYTVGLGQIKMGVCSDLEDINSIALTVTKQLLENNFIDPNDIGFLSVGTETLIDKSKSTKTVLMELFEKHGNTDIQGVDEKNACFGGTASLFAALDWLESSNCDGRLXXXXXXXXXXXXXXXXRCTGGAGAVAMLLGPNAPLIFDKGIRSHHMSHQWDFYKPKLDSEYPVYDGQLSIISYQKSIDKCFQLYKKKCLNKGLI--NQSMILFRENYYFCFHSPYTKLVEKSFARLVFNDIKDNPDIVEQFNEQLEDIKPFLHLNIENTYGNRDFDLSFLKFSDTLIKDKLRPGVLMAQNNGNMYTASLYGSLISVLIQTPIEELVGSRIVLFSYGSGLASCMFSLMITENKM---KLSEIKDSLNKIVDNLKNRIILSYKEFEDFLARRSSINCKCNVKPSTELSYLRSGTFYLSEIDEKYRRKY 1350
            D+GI A+EIYFP+  +DQ +LE+ D    GKYT+GLGQ KMG C+D EDINS+ +TV + L+E N +  + IG L VGTET+IDKSKS KT LM+LFE+ GNTDI+G+D  NAC+GGTA++F A++W+ESS+ DGR A+VVA DIA+YA   AR TGG GAVA+L+GPNAPLIF++G+R  HM H +DFYKP + SEYP+ DG+LSI  Y  ++D+C+ +Y KK   +     N       +  +  FHSPY KLV+KS AR++ ND  ++ +     N     ++ F  + +E+TY +RD + +F+K S  L   K +  +L++  NGNMYT+S+YGSL SVL Q   ++L G RI +FSYGSGLA+ ++SL +T++      L +I  SL  +   L +R  ++   F + +  R   +   N  P   +  L  GT+YL  +DEK+RR Y
Sbjct:   16 DVGIVALEIYFPSQYVDQAELEKYDGVDAGKYTIGLGQAKMGFCTDREDINSLCMTVVQNLMERNNLSYDCIGRLEVGTETIIDKSKSVKTNLMQLFEESGNTDIEGIDTTNACYGGTAAVFNAVNWIESSSWDGRYALVVAGDIAVYATGNARPTGGVGAVALLIGPNAPLIFERGLRGTHMQHAYDFYKPDMLSEYPIVDGKLSIQCYLSALDRCYSVYCKKIHAQWQKEGNDKDFTLNDFGFMIFHSPYCKLVQKSLARMLLNDFLNDQN--RDKNSIYSGLEAFGDVKLEDTYFDRDVEKAFMKASSELFSQKTKASLLVSNQNGNMYTSSVYGSLASVLAQYSPQQLAGKRIGVFSYGSGLAATLYSLKVTQDATPGSALDKITASLCDLKSRLDSRTGVAPDVFAENMKLREDTHHLVNYIPQGSIDSLFEGTWYLVRVDEKHRRTY 466

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BLAST of 3-hydroxy-3-methylglutaryl coenzyme A synthase vs. Ensembl Human
Match: HMGCS2 (3-hydroxy-3-methylglutaryl-CoA synthase 2 [Source:HGNC Symbol;Acc:HGNC:5008])

HSP 1 Score: 337.806 bits (865), Expect = 3.539e-110
Identity = 188/454 (41.41%), Postives = 266/454 (58.59%), Query Frame = 1

Query:   10 DIGIKAVEIYFPNTCIDQKDLEESDNC-LGKYTVGLGQIKMGVCSDLEDINSIALTVTKQLLENNFIDPNDIGFLSVGTETLIDKSKSTKTVLMELFEKHGNTDIQGVDEKNACFGGTASLFAALDWLESSNCDGRLXXXXXXXXXXXXXXXXRCTGGAGAVAMLLGPNAPLIFDKGIRSHHMSHQWDFYKPKLDSEYPVYDGQLSIISYQKSIDKCFQLYKKKCLNKGLINQSMILFREN--YYFCFHSPYTKLVEKSFARLVFND-IKDNPDIVEQFNEQLEDIKPFLHLNIENTYGNRDFDLSFLKFSDTLIKDKLRPGVLMAQNNGNMYTASLYGSLISVLIQTPIEELVGSRIVLFSYGSGLASCMFSLMITENKM---KLSEIKDSLNKIVDNLKNRIILSYKEFEDFLARRSSINCKCNVKPSTELSYLRSGTFYLSEIDEKYRRKY 1350
            D+GI A+E+YFP   +DQ DLE+ +N   GKYTVGLGQ +MG CS  EDINS+ LTV ++L+E   +  + +G L VGTET+IDKSK+ KTVLMELF+  GNTDI+G+D  NAC+GGTASLF A +W+ESS+ DG                                          +R  HM + +DFYKP L SEYP+ DG+LSI  Y +++D+C+  Y+KK  N+     S   F  +   Y  FH+P+ K+V+KS ARL+FND +  + D      + LE    F  L +E+TY N+D D + LK S  +   K +  + ++ +NGNMYT+SLYG L S+L     +EL GSRI  FSYGSGLA+  FS  ++++      L ++  S + +   L +R  +S +EF + + +R     K N  P  + + L  GT+YL  +DE++RRKY
Sbjct:   53 DVGILALEVYFPAQYVDQTDLEKYNNVEAGKYTVGLGQTRMGFCSVQEDINSLCLTVVQRLMERIQLPWDSVGRLEVGTETIIDKSKAVKTVLMELFQDSGNTDIEGIDTTNACYGGTASLFNAANWMESSSWDG------------------------------------------LRGTHMENVYDFYKPNLASEYPIVDGKLSIQCYLRALDRCYTSYRKKIQNQWKQAGSDRPFTLDDLQYMIFHTPFCKMVQKSLARLMFNDFLSASSDTQTSLYKGLE---AFGGLKLEDTYTNKDLDKALLKASQDMFDKKTKASLYLSTHNGNMYTSSLYGCLASLLSHHSAQELAGSRIGAFSYGSGLAASFFSFRVSQDAAPGSPLDKLVSSTSDLPKRLASRKCVSPEEFTEIMNQREQFYHKVNFSPPGDTNSLFPGTWYLERVDEQHRRKY 461

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BLAST of 3-hydroxy-3-methylglutaryl coenzyme A synthase vs. Ensembl Human
Match: HMGCS1 (3-hydroxy-3-methylglutaryl-CoA synthase 1 [Source:HGNC Symbol;Acc:HGNC:5007])

HSP 1 Score: 87.4261 bits (215), Expect = 2.437e-20
Identity = 44/80 (55.00%), Postives = 58/80 (72.50%), Query Frame = 1

Query:   10 DIGIKAVEIYFPNTCIDQKDLEESDNC-LGKYTVGLGQIKMGVCSDLEDINSIALTVTKQLLENNFIDPNDIGFLSVGTE 246
            D+GI A+EIYFP+  +DQ +LE+ D    GKYT+GLGQ KMG C+D EDINS+ +TV + L+E N +  + IG L VGTE
Sbjct:   16 DVGIVALEIYFPSQYVDQAELEKYDGVDAGKYTIGLGQAKMGFCTDREDINSLCMTVVQNLMERNNLSYDCIGRLEVGTE 95

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BLAST of 3-hydroxy-3-methylglutaryl coenzyme A synthase vs. Ensembl Celegans
Match: hmgs-1 (Hydroxymethylglutaryl-CoA synthase [Source:UniProtKB/Swiss-Prot;Acc:P54871])

HSP 1 Score: 267.314 bits (682), Expect = 2.073e-83
Identity = 179/455 (39.34%), Postives = 265/455 (58.24%), Query Frame = 1

Query:   10 DIGIKAVEIYFPNTCIDQKDLEESDNCL-GKYTVGLGQIKMGVCSDLEDINSIALTVTKQLLENNFIDPNDIGFLSVGTETLIDKSKSTKTVLMELFEKHGNTDIQGVDEKNACFGGTASLFAALDWLESSN-CDGRLXXXXXXXXXXXXXXXXRCTGGAGAVAMLLGPNAPLIFDKGIRSHHMSHQWDFYKP--KLDSEYPVYDGQLSIISYQKSIDKCFQLYKKKCLNKGLINQSMILFRENYYFCFHSPYTKLVEKSFARLVFNDIKDNPDIVEQFNEQLEDIKPFLHLNIENTYGNRDFDLSFLKFSDTLIKDKLRPGVLMAQNNGNMYTASLYGSLISVLIQTPIEELVGSR-IVLFSYGSGLASCMFSLMITENKMKLSEIKDSLNKIVDNLKNRIILSYKEFEDFLARRSSINCKCNVKPSTELSYLRSGTFYLSEIDEKYRRKYQIY 1359
            D+GI A+E+YFP   +DQ DLE+ +N   GKYT+GLGQ +MG CSD EDI SI+LTVT++L+E   I  + IG L VGTET+IDKSKS KT LM+LF   GN+DI+GVD KNACFGG  +L  A+DW+  ++  D + AIVV ADIAIY E  ARCTGGAGA+A L+ P+A +  D+   + HM + WDF+KP   + SEYPV DG LS+ SY +++   +  +  K +N+       +   +  +   HSP+TK+V+K  A + + D         Q   +  +     H   EN   +R      ++ S  + K+K  P ++  +  GNMYT SL+  L++ L     + + G + I+ F+YGSGLAS +F   + +    L +I+    + +  L +RI  + +EF + L +R        +  S   + L   T++L  +D+ YRR Y ++
Sbjct:   13 DVGIGAIELYFPQNFVDQNDLEKFNNVSSGKYTIGLGQQQMGFCSDNEDIVSISLTVTRKLIETYKISTDSIGCLVVGTETMIDKSKSVKTALMDLFP--GNSDIEGVDIKNACFGGAQALLHAIDWVTVNHPLDKKNAIVVVADIAIYEEGPARCTGGAGAIAFLICPDASIPIDRQFSACHMKNTWDFFKPITPIPSEYPVVDGSLSLSSYLEAVRMTYTYFISK-VNRHTTGIDGLNSFDGVF--LHSPFTKMVQKGLAVMNYTD--------SQLRHKQLNGNGVDHKLDEN---DRAGLAKMIELSAQVWKEKTDPYLVFNRRIGNMYTPSLFAQLLAYLAAD--DCVTGEKSILFFAYGSGLASAIFPGRVRQTS-NLDKIRQVAIRAIKRLDDRIQFTPEEFTETLQKREVFLRSKEIPKSPSETSLFPNTYFLDNMDKLYRRSYTLH 448

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BLAST of 3-hydroxy-3-methylglutaryl coenzyme A synthase vs. Ensembl Fly
Match: Hmgs (gene:FBgn0010611 transcript:FBtr0340059)

HSP 1 Score: 400.979 bits (1029), Expect = 3.551e-135
Identity = 216/460 (46.96%), Postives = 304/460 (66.09%), Query Frame = 1

Query:   10 DIGIKAVEIYFPNTCIDQKDLEESDNC-LGKYTVGLGQIKMGVCSDLEDINSIALTVTKQLLENNFIDPNDIGFLSVGTETLIDKSKSTKTVLMELFEKHGNTDIQGVDEKNACFGGTASLFAALDWLESSNCDGRLXXXXXXXXXXXXXXXXRCTGGAGAVAMLLGPNAPLIFDKGIRSHHMSHQWDFYKPKLDSEYPVYDGQLSIISYQKSIDKCFQLYKKKC--LNKGLINQSMILFRENYYFCFHSPYTKLVEKSFARLVFNDIKDNPDIVEQFNEQLEDIKPFLHLNIENTYGNRDFDLSFLKFSDTLIKDKLRPGVLMAQNNGNMYTASLYGSLISVLIQTPIEELVGSRIVLFSYGSGLASCMFSLMITENKMKLSEIKDSLNKIVDNLKNRIILSYKEFEDFLARRSSINCKCNVKPSTELSYLRSGTFYLSEIDEKYRRKYQIYNSEITNG 1380
            ++GI+A+EI FP+  +DQ +LE  D    GKYT+GLGQ KMG CSD ED+NS+ LTV  +LLE   +  ++IG L VGTET++DKSKS K+VLM+LF + GNTDI+G+D  NAC+GGTA+LF A++W+ESS+ DGRLA+ V ADIA+YA+ AAR TGGAGAVAML+GPNAPLI D+G+R+ HM H +DFYKP L SEYP  DG+LSI  Y  ++D C++LY+KK     K    Q   L   +    FH+P+ KLV+KS  RL FND   + +  E+  +Q  D++ F    +E+TY +RD + +F+  S  +   K +  +L+A   GNMYT S+Y  L+S+LI  P +ELVG RI LFSYGSGLA+ M+S+ +T++     +    L+ +   L +R  ++ ++F   +  R   N      P+  +S L  GT+YL ++D  +RR Y+     I+NG
Sbjct:    8 NVGIRAIEILFPSQYVDQTELETFDGASAGKYTIGLGQAKMGFCSDREDVNSLCLTVVSRLLERQHVKHSEIGRLEVGTETIVDKSKSVKSVLMQLFAESGNTDIEGIDTTNACYGGTAALFNAVNWVESSSWDGRLALAVCADIAVYAKGAARPTGGAGAVAMLVGPNAPLILDRGLRATHMEHAYDFYKPDLSSEYPTVDGKLSIQCYLSALDTCYRLYRKKFDQQQKDTSKQPASLSTFD-AILFHTPFCKLVQKSVGRLSFNDFLLSSE--EERTKQFPDLERFNTATLESTYFDRDVEKAFMTQSANIFASKTKKSLLLANQVGNMYTPSVYSGLVSLLISGPAQELVGKRIGLFSYGSGLAASMYSISVTQDAAAFEKFVSQLDYVQPLLNSREKVAPEQFSALMEVREKNNHAAPYTPTGSISALFPGTYYLKDVDALHRRTYE-RTPTISNG 463

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BLAST of 3-hydroxy-3-methylglutaryl coenzyme A synthase vs. Ensembl Fly
Match: Hmgs (gene:FBgn0010611 transcript:FBtr0087146)

HSP 1 Score: 400.979 bits (1029), Expect = 3.551e-135
Identity = 216/460 (46.96%), Postives = 304/460 (66.09%), Query Frame = 1

Query:   10 DIGIKAVEIYFPNTCIDQKDLEESDNC-LGKYTVGLGQIKMGVCSDLEDINSIALTVTKQLLENNFIDPNDIGFLSVGTETLIDKSKSTKTVLMELFEKHGNTDIQGVDEKNACFGGTASLFAALDWLESSNCDGRLXXXXXXXXXXXXXXXXRCTGGAGAVAMLLGPNAPLIFDKGIRSHHMSHQWDFYKPKLDSEYPVYDGQLSIISYQKSIDKCFQLYKKKC--LNKGLINQSMILFRENYYFCFHSPYTKLVEKSFARLVFNDIKDNPDIVEQFNEQLEDIKPFLHLNIENTYGNRDFDLSFLKFSDTLIKDKLRPGVLMAQNNGNMYTASLYGSLISVLIQTPIEELVGSRIVLFSYGSGLASCMFSLMITENKMKLSEIKDSLNKIVDNLKNRIILSYKEFEDFLARRSSINCKCNVKPSTELSYLRSGTFYLSEIDEKYRRKYQIYNSEITNG 1380
            ++GI+A+EI FP+  +DQ +LE  D    GKYT+GLGQ KMG CSD ED+NS+ LTV  +LLE   +  ++IG L VGTET++DKSKS K+VLM+LF + GNTDI+G+D  NAC+GGTA+LF A++W+ESS+ DGRLA+ V ADIA+YA+ AAR TGGAGAVAML+GPNAPLI D+G+R+ HM H +DFYKP L SEYP  DG+LSI  Y  ++D C++LY+KK     K    Q   L   +    FH+P+ KLV+KS  RL FND   + +  E+  +Q  D++ F    +E+TY +RD + +F+  S  +   K +  +L+A   GNMYT S+Y  L+S+LI  P +ELVG RI LFSYGSGLA+ M+S+ +T++     +    L+ +   L +R  ++ ++F   +  R   N      P+  +S L  GT+YL ++D  +RR Y+     I+NG
Sbjct:    8 NVGIRAIEILFPSQYVDQTELETFDGASAGKYTIGLGQAKMGFCSDREDVNSLCLTVVSRLLERQHVKHSEIGRLEVGTETIVDKSKSVKSVLMQLFAESGNTDIEGIDTTNACYGGTAALFNAVNWVESSSWDGRLALAVCADIAVYAKGAARPTGGAGAVAMLVGPNAPLILDRGLRATHMEHAYDFYKPDLSSEYPTVDGKLSIQCYLSALDTCYRLYRKKFDQQQKDTSKQPASLSTFD-AILFHTPFCKLVQKSVGRLSFNDFLLSSE--EERTKQFPDLERFNTATLESTYFDRDVEKAFMTQSANIFASKTKKSLLLANQVGNMYTPSVYSGLVSLLISGPAQELVGKRIGLFSYGSGLAASMYSISVTQDAAAFEKFVSQLDYVQPLLNSREKVAPEQFSALMEVREKNNHAAPYTPTGSISALFPGTYYLKDVDALHRRTYE-RTPTISNG 463

[Close]

BLAST of 3-hydroxy-3-methylglutaryl coenzyme A synthase vs. Ensembl Fly
Match: Hmgs (gene:FBgn0010611 transcript:FBtr0087147)

HSP 1 Score: 400.979 bits (1029), Expect = 3.551e-135
Identity = 216/460 (46.96%), Postives = 304/460 (66.09%), Query Frame = 1

Query:   10 DIGIKAVEIYFPNTCIDQKDLEESDNC-LGKYTVGLGQIKMGVCSDLEDINSIALTVTKQLLENNFIDPNDIGFLSVGTETLIDKSKSTKTVLMELFEKHGNTDIQGVDEKNACFGGTASLFAALDWLESSNCDGRLXXXXXXXXXXXXXXXXRCTGGAGAVAMLLGPNAPLIFDKGIRSHHMSHQWDFYKPKLDSEYPVYDGQLSIISYQKSIDKCFQLYKKKC--LNKGLINQSMILFRENYYFCFHSPYTKLVEKSFARLVFNDIKDNPDIVEQFNEQLEDIKPFLHLNIENTYGNRDFDLSFLKFSDTLIKDKLRPGVLMAQNNGNMYTASLYGSLISVLIQTPIEELVGSRIVLFSYGSGLASCMFSLMITENKMKLSEIKDSLNKIVDNLKNRIILSYKEFEDFLARRSSINCKCNVKPSTELSYLRSGTFYLSEIDEKYRRKYQIYNSEITNG 1380
            ++GI+A+EI FP+  +DQ +LE  D    GKYT+GLGQ KMG CSD ED+NS+ LTV  +LLE   +  ++IG L VGTET++DKSKS K+VLM+LF + GNTDI+G+D  NAC+GGTA+LF A++W+ESS+ DGRLA+ V ADIA+YA+ AAR TGGAGAVAML+GPNAPLI D+G+R+ HM H +DFYKP L SEYP  DG+LSI  Y  ++D C++LY+KK     K    Q   L   +    FH+P+ KLV+KS  RL FND   + +  E+  +Q  D++ F    +E+TY +RD + +F+  S  +   K +  +L+A   GNMYT S+Y  L+S+LI  P +ELVG RI LFSYGSGLA+ M+S+ +T++     +    L+ +   L +R  ++ ++F   +  R   N      P+  +S L  GT+YL ++D  +RR Y+     I+NG
Sbjct:    8 NVGIRAIEILFPSQYVDQTELETFDGASAGKYTIGLGQAKMGFCSDREDVNSLCLTVVSRLLERQHVKHSEIGRLEVGTETIVDKSKSVKSVLMQLFAESGNTDIEGIDTTNACYGGTAALFNAVNWVESSSWDGRLALAVCADIAVYAKGAARPTGGAGAVAMLVGPNAPLILDRGLRATHMEHAYDFYKPDLSSEYPTVDGKLSIQCYLSALDTCYRLYRKKFDQQQKDTSKQPASLSTFD-AILFHTPFCKLVQKSVGRLSFNDFLLSSE--EERTKQFPDLERFNTATLESTYFDRDVEKAFMTQSANIFASKTKKSLLLANQVGNMYTPSVYSGLVSLLISGPAQELVGKRIGLFSYGSGLAASMYSISVTQDAAAFEKFVSQLDYVQPLLNSREKVAPEQFSALMEVREKNNHAAPYTPTGSISALFPGTYYLKDVDALHRRTYE-RTPTISNG 463

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BLAST of 3-hydroxy-3-methylglutaryl coenzyme A synthase vs. Ensembl Fly
Match: Hmgs (gene:FBgn0010611 transcript:FBtr0087148)

HSP 1 Score: 400.979 bits (1029), Expect = 3.551e-135
Identity = 216/460 (46.96%), Postives = 304/460 (66.09%), Query Frame = 1

Query:   10 DIGIKAVEIYFPNTCIDQKDLEESDNC-LGKYTVGLGQIKMGVCSDLEDINSIALTVTKQLLENNFIDPNDIGFLSVGTETLIDKSKSTKTVLMELFEKHGNTDIQGVDEKNACFGGTASLFAALDWLESSNCDGRLXXXXXXXXXXXXXXXXRCTGGAGAVAMLLGPNAPLIFDKGIRSHHMSHQWDFYKPKLDSEYPVYDGQLSIISYQKSIDKCFQLYKKKC--LNKGLINQSMILFRENYYFCFHSPYTKLVEKSFARLVFNDIKDNPDIVEQFNEQLEDIKPFLHLNIENTYGNRDFDLSFLKFSDTLIKDKLRPGVLMAQNNGNMYTASLYGSLISVLIQTPIEELVGSRIVLFSYGSGLASCMFSLMITENKMKLSEIKDSLNKIVDNLKNRIILSYKEFEDFLARRSSINCKCNVKPSTELSYLRSGTFYLSEIDEKYRRKYQIYNSEITNG 1380
            ++GI+A+EI FP+  +DQ +LE  D    GKYT+GLGQ KMG CSD ED+NS+ LTV  +LLE   +  ++IG L VGTET++DKSKS K+VLM+LF + GNTDI+G+D  NAC+GGTA+LF A++W+ESS+ DGRLA+ V ADIA+YA+ AAR TGGAGAVAML+GPNAPLI D+G+R+ HM H +DFYKP L SEYP  DG+LSI  Y  ++D C++LY+KK     K    Q   L   +    FH+P+ KLV+KS  RL FND   + +  E+  +Q  D++ F    +E+TY +RD + +F+  S  +   K +  +L+A   GNMYT S+Y  L+S+LI  P +ELVG RI LFSYGSGLA+ M+S+ +T++     +    L+ +   L +R  ++ ++F   +  R   N      P+  +S L  GT+YL ++D  +RR Y+     I+NG
Sbjct:    8 NVGIRAIEILFPSQYVDQTELETFDGASAGKYTIGLGQAKMGFCSDREDVNSLCLTVVSRLLERQHVKHSEIGRLEVGTETIVDKSKSVKSVLMQLFAESGNTDIEGIDTTNACYGGTAALFNAVNWVESSSWDGRLALAVCADIAVYAKGAARPTGGAGAVAMLVGPNAPLILDRGLRATHMEHAYDFYKPDLSSEYPTVDGKLSIQCYLSALDTCYRLYRKKFDQQQKDTSKQPASLSTFD-AILFHTPFCKLVQKSVGRLSFNDFLLSSE--EERTKQFPDLERFNTATLESTYFDRDVEKAFMTQSANIFASKTKKSLLLANQVGNMYTPSVYSGLVSLLISGPAQELVGKRIGLFSYGSGLAASMYSISVTQDAAAFEKFVSQLDYVQPLLNSREKVAPEQFSALMEVREKNNHAAPYTPTGSISALFPGTYYLKDVDALHRRTYE-RTPTISNG 463

[Close]

BLAST of 3-hydroxy-3-methylglutaryl coenzyme A synthase vs. Ensembl Fly
Match: Hmgs (gene:FBgn0010611 transcript:FBtr0087145)

HSP 1 Score: 400.979 bits (1029), Expect = 3.551e-135
Identity = 216/460 (46.96%), Postives = 304/460 (66.09%), Query Frame = 1

Query:   10 DIGIKAVEIYFPNTCIDQKDLEESDNC-LGKYTVGLGQIKMGVCSDLEDINSIALTVTKQLLENNFIDPNDIGFLSVGTETLIDKSKSTKTVLMELFEKHGNTDIQGVDEKNACFGGTASLFAALDWLESSNCDGRLXXXXXXXXXXXXXXXXRCTGGAGAVAMLLGPNAPLIFDKGIRSHHMSHQWDFYKPKLDSEYPVYDGQLSIISYQKSIDKCFQLYKKKC--LNKGLINQSMILFRENYYFCFHSPYTKLVEKSFARLVFNDIKDNPDIVEQFNEQLEDIKPFLHLNIENTYGNRDFDLSFLKFSDTLIKDKLRPGVLMAQNNGNMYTASLYGSLISVLIQTPIEELVGSRIVLFSYGSGLASCMFSLMITENKMKLSEIKDSLNKIVDNLKNRIILSYKEFEDFLARRSSINCKCNVKPSTELSYLRSGTFYLSEIDEKYRRKYQIYNSEITNG 1380
            ++GI+A+EI FP+  +DQ +LE  D    GKYT+GLGQ KMG CSD ED+NS+ LTV  +LLE   +  ++IG L VGTET++DKSKS K+VLM+LF + GNTDI+G+D  NAC+GGTA+LF A++W+ESS+ DGRLA+ V ADIA+YA+ AAR TGGAGAVAML+GPNAPLI D+G+R+ HM H +DFYKP L SEYP  DG+LSI  Y  ++D C++LY+KK     K    Q   L   +    FH+P+ KLV+KS  RL FND   + +  E+  +Q  D++ F    +E+TY +RD + +F+  S  +   K +  +L+A   GNMYT S+Y  L+S+LI  P +ELVG RI LFSYGSGLA+ M+S+ +T++     +    L+ +   L +R  ++ ++F   +  R   N      P+  +S L  GT+YL ++D  +RR Y+     I+NG
Sbjct:    8 NVGIRAIEILFPSQYVDQTELETFDGASAGKYTIGLGQAKMGFCSDREDVNSLCLTVVSRLLERQHVKHSEIGRLEVGTETIVDKSKSVKSVLMQLFAESGNTDIEGIDTTNACYGGTAALFNAVNWVESSSWDGRLALAVCADIAVYAKGAARPTGGAGAVAMLVGPNAPLILDRGLRATHMEHAYDFYKPDLSSEYPTVDGKLSIQCYLSALDTCYRLYRKKFDQQQKDTSKQPASLSTFD-AILFHTPFCKLVQKSVGRLSFNDFLLSSE--EERTKQFPDLERFNTATLESTYFDRDVEKAFMTQSANIFASKTKKSLLLANQVGNMYTPSVYSGLVSLLISGPAQELVGKRIGLFSYGSGLAASMYSISVTQDAAAFEKFVSQLDYVQPLLNSREKVAPEQFSALMEVREKNNHAAPYTPTGSISALFPGTYYLKDVDALHRRTYE-RTPTISNG 463

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BLAST of 3-hydroxy-3-methylglutaryl coenzyme A synthase vs. Ensembl Zebrafish
Match: hmgcs1 (3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) [Source:ZFIN;Acc:ZDB-GENE-040426-1042])

HSP 1 Score: 399.438 bits (1025), Expect = 1.339e-133
Identity = 216/453 (47.68%), Postives = 301/453 (66.45%), Query Frame = 1

Query:   10 DIGIKAVEIYFPNTCIDQKDLEESDNC-LGKYTVGLGQIKMGVCSDLEDINSIALTVTKQLLENNFIDPNDIGFLSVGTETLIDKSKSTKTVLMELFEKHGNTDIQGVDEKNACFGGTASLFAALDWLESSNCDGRLXXXXXXXXXXXXXXXXRCTGGAGAVAMLLGPNAPLIFDKGIRSHHMSHQWDFYKPKLDSEYPVYDGQLSIISYQKSIDKCFQLYKKKCLNKGLI--NQSMILFRENYYFCFHSPYTKLVEKSFARLVFNDIKDNPDIVEQFNEQLEDIKPFLHLNIENTYGNRDFDLSFLKFSDTLIKDKLRPGVLMAQNNGNMYTASLYGSLISVLIQTPIEELVGSRIVLFSYGSGLASCMFSLMITENKMK---LSEIKDSLNKIVDNLKNRIILSYKEFEDFLARRSSINCKCNVKPSTELSYLRSGTFYLSEIDEKYRRKY 1350
            D+GI A+E+Y P+  +DQ +LEE D    GKYTVGLGQ +MG CSD EDINS+ LTV ++L+E N +    +G L VGTET+IDKSKSTKTVLM+LFE+ GNTD++GVD  NAC+GGTA+LF A++W+ESS+ DGR A+VVA DIA+YA  +AR TGGAGAVAML+GPNAPL F++G+R  HM H +DFYKP + SEYPV DG+LSI  Y  ++D+C+ +YK K   +      +      +  +  FHSPY KLV+KS ARL+ ND   +P    + +     ++ F  + IE+TY +RD + +F+K S  L  DK +  +L++  NGNMYT S+YG L SVL Q   ++L G RI +FSYGSG A+ ++S+ +T++      L ++  SL  +   L +R  +S   F + +  R   +   N  P   +  L  GT+YL+ +DEK+RR+Y
Sbjct:   16 DVGIIAMEVYVPSQYVDQAELEEYDGVGAGKYTVGLGQARMGFCSDREDINSLCLTVVQRLMERNGLSYESVGRLEVGTETIIDKSKSTKTVLMQLFEESGNTDVEGVDTTNACYGGTAALFNAVNWVESSSWDGRYALVVAGDIAVYATGSARPTGGAGAVAMLVGPNAPLAFERGLRGTHMQHAYDFYKPDMVSEYPVVDGKLSIQCYLSALDQCYSVYKNKIHARWQREGTEGRCSLEDFGFMVFHSPYCKLVQKSLARLMLNDFLCHPSPNME-SGPFSGLEAFRDVKIEDTYFDRDVEKAFMKASSELFDDKTKASLLISNQNGNMYTPSVYGCLASVLAQHTPQQLAGQRIGVFSYGSGFAATLYSIKVTQDGTPGSALDKLVSSLCDLPARLDSRQKVSPGVFAETMKLREETHHLANYIPQGSVDELFPGTWYLTRVDEKHRRQY 467

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Query:   10 DIGIKAVEIYFPNTCIDQKDLEESDNC-LGKYTVGLGQIKMGVCSDLEDINSIALTVTKQLLENNFIDPNDIGFLSVGTETLIDKSKSTKTVLMELFEKHGNTDIQGVDEKNACFGGTASLFAALDWLESSNCDGRLXXXXXXXXXXXXXXXXRCTGGAGAVAMLLGPNAPLIFDKGIRSHHMSHQWDFYKPKLDSEYPVYDGQLSIISYQKSIDKCFQLYKKKCLNKGLI--NQSMILFRENYYFCFHSPYTKLVEKSFARLVFNDIKDNPDIVEQFNEQLEDIKPFLHLNIENTYGNRDFDLSFLKFSDTLIKDKLRPGVLMAQNNGNMYTASLYGSLISVLIQTPIEELVGSRIVLFSYGSGLASCMFSLMITENKMK---LSEIKDSLNKIVDNLKNRIILSYKEFEDFLARRSSINCKCNVKPSTELSYLRSGTFYLSEIDEKYRRKY 1350
            D+GI A+E+Y P+  +DQ +LEE D    GKYTVGLGQ +MG CSD EDINS+ LTV ++L+E N +    +G L VGTET+IDKSKSTKTVLM+LFE+ GNTD++GVD  NAC+GGTA+LF A++W+ESS+ DGR A+VVA DIA+YA  +AR TGGAGAVAML+GPNAPL F++G+R  HM H +DFYKP + SEYPV DG+LSI  Y  ++D+C+ +YK K   +      +      +  +  FHSPY KLV+KS ARL+ ND   +P    + +     ++ F  + IE+TY +RD + +F+K S  L  DK +  +L++  NGNMYT S+YG L SVL Q   ++L G RI +FSYGSG A+ ++S+ +T++      L ++  SL  +   L +R  +S   F + +  R   +   N  P   +  L  GT+YL+ +DEK+RR+Y
Sbjct:   16 DVGIIAMEVYVPSQYVDQAELEEYDGVGAGKYTVGLGQARMGFCSDREDINSLCLTVVQRLMERNGLSYESVGRLEVGTETIIDKSKSTKTVLMQLFEESGNTDVEGVDTTNACYGGTAALFNAVNWVESSSWDGRYALVVAGDIAVYATGSARPTGGAGAVAMLVGPNAPLAFERGLRGTHMQHAYDFYKPDMVSEYPVVDGKLSIQCYLSALDQCYSVYKNKIHARWQREGTEGRCSLEDFGFMVFHSPYCKLVQKSLARLMLNDFLCHPSPNME-SGPFSGLEAFRDVKIEDTYFDRDVEKAFMKASSELFDDKTKASLLISNQNGNMYTPSVYGCLASVLAQHTPQQLAGQRIGVFSYGSGFAATLYSIKVTQDGTPGSALDKLVSSLCDLPARLDSRQKVSPGVFAETMKLREETHHLANYIPQGSVDELFPGTWYLTRVDEKHRRQY 467

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BLAST of 3-hydroxy-3-methylglutaryl coenzyme A synthase vs. Ensembl Zebrafish
Match: hmgcs1 (3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) [Source:ZFIN;Acc:ZDB-GENE-040426-1042])

HSP 1 Score: 294.278 bits (752), Expect = 5.153e-96
Identity = 153/267 (57.30%), Postives = 198/267 (74.16%), Query Frame = 1

Query:   10 DIGIKAVEIYFPNTCIDQKDLEESDNC-LGKYTVGLGQIKMGVCSDLEDINSIALTVTKQLLENNFIDPNDIGFLSVGTETLIDKSKSTKTVLMELFEKHGNTDIQGVDEKNACFGGTASLFAALDWLESSNCDGRLXXXXXXXXXXXXXXXXRCTGGAGAVAMLLGPNAPLIFDKGIRSHHMSHQWDFYKPKLDSEYPVYDGQLSIISYQKSIDKCFQLYKKKCLNKGLI--NQSMILFRENYYFCFHSPYTKLVEKSFARLVFND 801
            D+GI A+E+Y P+  +DQ +LEE D    GKYTVGLGQ +MG CSD EDINS+ LTV ++L+E N +    +G L VGTET+IDKSKSTKTVLM+LFE+ GNTD++GVD  NAC+GGTA+LF A++W+ESS+ DGR A+VVA DIA+YA  +AR TGGAGAVAML+GPNAPL F++G+R  HM H +DFYKP + SEYPV DG+LSI  Y  ++D+C+ +YK K   +      +      +  +  FHSPY KLV+KS ARL+ ND
Sbjct:   16 DVGIIAMEVYVPSQYVDQAELEEYDGVGAGKYTVGLGQARMGFCSDREDINSLCLTVVQRLMERNGLSYESVGRLEVGTETIIDKSKSTKTVLMQLFEESGNTDVEGVDTTNACYGGTAALFNAVNWVESSSWDGRYALVVAGDIAVYATGSARPTGGAGAVAMLVGPNAPLAFERGLRGTHMQHAYDFYKPDMVSEYPVVDGKLSIQCYLSALDQCYSVYKNKIHARWQREGTEGRCSLEDFGFMVFHSPYCKLVQKSLARLMLND 282

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BLAST of 3-hydroxy-3-methylglutaryl coenzyme A synthase vs. Ensembl Zebrafish
Match: hmgcs1 (3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) [Source:ZFIN;Acc:ZDB-GENE-040426-1042])

HSP 1 Score: 198.749 bits (504), Expect = 2.765e-60
Identity = 107/168 (63.69%), Postives = 135/168 (80.36%), Query Frame = 1

Query:   10 DIGIKAVEIYFPNTCIDQKDLEESDNC-LGKYTVGLGQIKMGVCSDLEDINSIALTVTKQLLENNFIDPNDIGFLSVGTETLIDKSKSTKTVLMELFEKHGNTDIQGVDEKNACFGGTASLFAALDWLESSNCDGRLXXXXXXXXXXXXXXXXRCTGGAGAVAMLLGP 510
            D+GI A+E+Y P+  +DQ +LEE D    GKYTVGLGQ +MG CSD EDINS+ LTV ++L+E N +    +G L VGTET+IDKSKSTKTVLM+LFE+ GNTD++GVD  NAC+GGTA+LF A++W+ESS+ DGR A+VVA DIA+YA  +AR TGGAGAVAML+GP
Sbjct:   34 DVGIIAMEVYVPSQYVDQAELEEYDGVGAGKYTVGLGQARMGFCSDREDINSLCLTVVQRLMERNGLSYESVGRLEVGTETIIDKSKSTKTVLMQLFEESGNTDVEGVDTTNACYGGTAALFNAVNWVESSSWDGRYALVVAGDIAVYATGSARPTGGAGAVAMLVGP 201

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BLAST of 3-hydroxy-3-methylglutaryl coenzyme A synthase vs. Ensembl Xenopus
Match: hmgcs1 (3-hydroxy-3-methylglutaryl-CoA synthase 1 [Source:NCBI gene;Acc:100145212])

HSP 1 Score: 399.438 bits (1025), Expect = 1.449e-133
Identity = 225/455 (49.45%), Postives = 304/455 (66.81%), Query Frame = 1

Query:   10 DIGIKAVEIYFPNTCIDQKDLEESDNC-LGKYTVGLGQIKMGVCSDLEDINSIALTVTKQLLENNFIDPNDIGFLSVGTETLIDKSKSTKTVLMELFEKHGNTDIQGVDEKNACFGGTASLFAALDWLESSNCDGRLXXXXXXXXXXXXXXXXRCTGGAGAVAMLLGPNAPLIFDKGIRSHHMSHQWDFYKPKLDSEYPVYDGQLSIISYQKSIDKCFQLYKKKCLNKGLINQSMILFREN--YYFCFHSPYTKLVEKSFARLVFND-IKD-NPDIVEQFNEQLEDIKPFLHLNIENTYGNRDFDLSFLKFSDTLIKDKLRPGVLMAQNNGNMYTASLYGSLISVLIQTPIEELVGSRIVLFSYGSGLASCMFSLMITENKM---KLSEIKDSLNKIVDNLKNRIILSYKEFEDFLARRSSINCKCNVKPSTELSYLRSGTFYLSEIDEKYRRKY 1350
            D+GI A+EIYFP+  +DQ +LE+ D    GKYT+GLGQ KMG CSD EDINS+ LTV ++L+E N +  + IG L VGTET+IDKSKS KTVLM+LFE  GNTD++G+D  NAC+GGTA+LF A++W+ESS+ DGR A+VVA DIA+YA  +AR TGGAGAVAML+GPNA L+F++G+R  HM H +DFYKP ++SEYPV DG+LSI  Y  ++D C+  Y+KK   +     +   F  N   +  FHSPY KLV+KS ARL+ ND I D +PD+       L+    F  L +E TY +RD + +FLK S  L  DK +  +L+++ NGNMYT S+YG L SVL Q   ++L G RI +FSYGSG A+ M+SL ++++ M    L ++  SL+ +   L +R  +S   F D +  R   +   N  P   +  L  GT+YL  +DEK+RR Y
Sbjct:    7 DVGIVALEIYFPSQYVDQVELEKFDGVSAGKYTIGLGQCKMGFCSDREDINSLCLTVVQRLMERNNLSYDCIGRLEVGTETIIDKSKSVKTVLMQLFEDSGNTDVEGIDTTNACYGGTAALFNAVNWVESSSWDGRYALVVAGDIAVYATGSARPTGGAGAVAMLVGPNATLVFERGLRGTHMQHAYDFYKPDMESEYPVVDGKLSIQCYLSALDHCYTTYRKKIHAQWQKEGTDKPFTLNDFGFMIFHSPYCKLVQKSLARLLVNDFISDSDPDMESGMYVGLDS---FRDLKLEETYFDRDVEKAFLKASTELFNDKTKASLLVSRENGNMYTPSVYGCLASVLAQYSPQQLAGQRIGVFSYGSGFAATMYSLRVSQDAMPGSSLDKLTSSLSDLKARLDSRKNVSPSNFADTMKLRQDTHHLANYIPQGSVDDLFPGTWYLVRVDEKHRRFY 458

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BLAST of 3-hydroxy-3-methylglutaryl coenzyme A synthase vs. Ensembl Xenopus
Match: hmgcs1 (3-hydroxy-3-methylglutaryl-CoA synthase 1 [Source:NCBI gene;Acc:100145212])

HSP 1 Score: 399.053 bits (1024), Expect = 2.217e-133
Identity = 225/455 (49.45%), Postives = 304/455 (66.81%), Query Frame = 1

Query:   10 DIGIKAVEIYFPNTCIDQKDLEESDNC-LGKYTVGLGQIKMGVCSDLEDINSIALTVTKQLLENNFIDPNDIGFLSVGTETLIDKSKSTKTVLMELFEKHGNTDIQGVDEKNACFGGTASLFAALDWLESSNCDGRLXXXXXXXXXXXXXXXXRCTGGAGAVAMLLGPNAPLIFDKGIRSHHMSHQWDFYKPKLDSEYPVYDGQLSIISYQKSIDKCFQLYKKKCLNKGLINQSMILFREN--YYFCFHSPYTKLVEKSFARLVFND-IKD-NPDIVEQFNEQLEDIKPFLHLNIENTYGNRDFDLSFLKFSDTLIKDKLRPGVLMAQNNGNMYTASLYGSLISVLIQTPIEELVGSRIVLFSYGSGLASCMFSLMITENKM---KLSEIKDSLNKIVDNLKNRIILSYKEFEDFLARRSSINCKCNVKPSTELSYLRSGTFYLSEIDEKYRRKY 1350
            D+GI A+EIYFP+  +DQ +LE+ D    GKYT+GLGQ KMG CSD EDINS+ LTV ++L+E N +  + IG L VGTET+IDKSKS KTVLM+LFE  GNTD++G+D  NAC+GGTA+LF A++W+ESS+ DGR A+VVA DIA+YA  +AR TGGAGAVAML+GPNA L+F++G+R  HM H +DFYKP ++SEYPV DG+LSI  Y  ++D C+  Y+KK   +     +   F  N   +  FHSPY KLV+KS ARL+ ND I D +PD+       L+    F  L +E TY +RD + +FLK S  L  DK +  +L+++ NGNMYT S+YG L SVL Q   ++L G RI +FSYGSG A+ M+SL ++++ M    L ++  SL+ +   L +R  +S   F D +  R   +   N  P   +  L  GT+YL  +DEK+RR Y
Sbjct:   16 DVGIVALEIYFPSQYVDQVELEKFDGVSAGKYTIGLGQCKMGFCSDREDINSLCLTVVQRLMERNNLSYDCIGRLEVGTETIIDKSKSVKTVLMQLFEDSGNTDVEGIDTTNACYGGTAALFNAVNWVESSSWDGRYALVVAGDIAVYATGSARPTGGAGAVAMLVGPNATLVFERGLRGTHMQHAYDFYKPDMESEYPVVDGKLSIQCYLSALDHCYTTYRKKIHAQWQKEGTDKPFTLNDFGFMIFHSPYCKLVQKSLARLLVNDFISDSDPDMESGMYVGLDS---FRDLKLEETYFDRDVEKAFLKASTELFNDKTKASLLVSRENGNMYTPSVYGCLASVLAQYSPQQLAGQRIGVFSYGSGFAATMYSLRVSQDAMPGSSLDKLTSSLSDLKARLDSRKNVSPSNFADTMKLRQDTHHLANYIPQGSVDDLFPGTWYLVRVDEKHRRFY 467

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BLAST of 3-hydroxy-3-methylglutaryl coenzyme A synthase vs. Ensembl Xenopus
Match: hmgcs1 (3-hydroxy-3-methylglutaryl-CoA synthase 1 [Source:NCBI gene;Acc:100145212])

HSP 1 Score: 399.438 bits (1025), Expect = 3.430e-133
Identity = 225/455 (49.45%), Postives = 304/455 (66.81%), Query Frame = 1

Query:   10 DIGIKAVEIYFPNTCIDQKDLEESDNC-LGKYTVGLGQIKMGVCSDLEDINSIALTVTKQLLENNFIDPNDIGFLSVGTETLIDKSKSTKTVLMELFEKHGNTDIQGVDEKNACFGGTASLFAALDWLESSNCDGRLXXXXXXXXXXXXXXXXRCTGGAGAVAMLLGPNAPLIFDKGIRSHHMSHQWDFYKPKLDSEYPVYDGQLSIISYQKSIDKCFQLYKKKCLNKGLINQSMILFREN--YYFCFHSPYTKLVEKSFARLVFND-IKD-NPDIVEQFNEQLEDIKPFLHLNIENTYGNRDFDLSFLKFSDTLIKDKLRPGVLMAQNNGNMYTASLYGSLISVLIQTPIEELVGSRIVLFSYGSGLASCMFSLMITENKM---KLSEIKDSLNKIVDNLKNRIILSYKEFEDFLARRSSINCKCNVKPSTELSYLRSGTFYLSEIDEKYRRKY 1350
            D+GI A+EIYFP+  +DQ +LE+ D    GKYT+GLGQ KMG CSD EDINS+ LTV ++L+E N +  + IG L VGTET+IDKSKS KTVLM+LFE  GNTD++G+D  NAC+GGTA+LF A++W+ESS+ DGR A+VVA DIA+YA  +AR TGGAGAVAML+GPNA L+F++G+R  HM H +DFYKP ++SEYPV DG+LSI  Y  ++D C+  Y+KK   +     +   F  N   +  FHSPY KLV+KS ARL+ ND I D +PD+       L+    F  L +E TY +RD + +FLK S  L  DK +  +L+++ NGNMYT S+YG L SVL Q   ++L G RI +FSYGSG A+ M+SL ++++ M    L ++  SL+ +   L +R  +S   F D +  R   +   N  P   +  L  GT+YL  +DEK+RR Y
Sbjct:   41 DVGIVALEIYFPSQYVDQVELEKFDGVSAGKYTIGLGQCKMGFCSDREDINSLCLTVVQRLMERNNLSYDCIGRLEVGTETIIDKSKSVKTVLMQLFEDSGNTDVEGIDTTNACYGGTAALFNAVNWVESSSWDGRYALVVAGDIAVYATGSARPTGGAGAVAMLVGPNATLVFERGLRGTHMQHAYDFYKPDMESEYPVVDGKLSIQCYLSALDHCYTTYRKKIHAQWQKEGTDKPFTLNDFGFMIFHSPYCKLVQKSLARLLVNDFISDSDPDMESGMYVGLDS---FRDLKLEETYFDRDVEKAFLKASTELFNDKTKASLLVSRENGNMYTPSVYGCLASVLAQYSPQQLAGQRIGVFSYGSGFAATMYSLRVSQDAMPGSSLDKLTSSLSDLKARLDSRKNVSPSNFADTMKLRQDTHHLANYIPQGSVDDLFPGTWYLVRVDEKHRRFY 492

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BLAST of 3-hydroxy-3-methylglutaryl coenzyme A synthase vs. Ensembl Mouse
Match: Hmgcs2 (3-hydroxy-3-methylglutaryl-Coenzyme A synthase 2 [Source:MGI Symbol;Acc:MGI:101939])

HSP 1 Score: 396.356 bits (1017), Expect = 1.445e-132
Identity = 214/453 (47.24%), Postives = 296/453 (65.34%), Query Frame = 1

Query:   10 DIGIKAVEIYFPNTCIDQKDLEESDNC-LGKYTVGLGQIKMGVCSDLEDINSIALTVTKQLLENNFIDPNDIGFLSVGTETLIDKSKSTKTVLMELFEKHGNTDIQGVDEKNACFGGTASLFAALDWLESSNCDGRLXXXXXXXXXXXXXXXXRCTGGAGAVAMLLGPNAPLIFDKGIRSHHMSHQWDFYKPKLDSEYPVYDGQLSIISYQKSIDKCFQLYKKKCLN--KGLINQSMILFRENYYFCFHSPYTKLVEKSFARLVFNDIKDNPDIVEQFNEQLEDIKPFLHLNIENTYGNRDFDLSFLKFSDTLIKDKLRPGVLMAQNNGNMYTASLYGSLISVLIQTPIEELVGSRIVLFSYGSGLASCMFSLMITENKMKLSEIKDSLNKIVD---NLKNRIILSYKEFEDFLARRSSINCKCNVKPSTELSYLRSGTFYLSEIDEKYRRKY 1350
            D+GI A+E+YFP   +DQ DLE+ +N   GKYTVGLGQ +MG CS  EDINS+ LTV ++L+E   +  + +G L VGTET+IDKSK+ KTVLMELF+  GNTDI+G+D  NAC+GGTASLF A +W+ESS  DGR A+VV  DIA+Y    AR TGGAGAVAML+GP APL+ ++G+R  HM + +DFYKP L SEYP+ DG+LSI  Y +++D+C+  Y+KK  N  K   N       +  Y  FH+P+ K+V+KS ARL+FND   +    ++ N   + ++ F  L +E TY N+D D + LK S  +   K +  + ++ NNGNMYT+SLYG L S+L     +EL GSRI  FSYGSGLA+  FS  ++++    S ++  ++ + D    L +R  +S +EF + + +R     K N  P  + S L  GT+YL  +DE +RRKY
Sbjct:   53 DVGILALEVYFPAQYVDQTDLEKFNNVEAGKYTVGLGQTRMGFCSVQEDINSLCLTVVQRLMERTKLPWDAVGRLEVGTETIIDKSKAVKTVLMELFQDSGNTDIEGIDTTNACYGGTASLFNAANWMESSYWDGRYALVVCGDIAVYPSGNARPTGGAGAVAMLIGPKAPLVLEQGLRGTHMENAYDFYKPNLASEYPLVDGKLSIQCYLRALDRCYAAYRKKIQNQWKQAGNNQPFTLDDVQYMIFHTPFCKMVQKSLARLMFNDFLSSSS--DKQNNLYKGLEAFRGLKLEETYTNKDVDKALLKASLDMFNQKTKASLYLSTNNGNMYTSSLYGCLASLLSHHSAQELAGSRIGAFSYGSGLAASFFSFRVSKDASPGSPLEKLVSSVSDLPKRLDSRRRMSPEEFTEIMNQREQFYHKVNFSPPGDTSNLFPGTWYLERVDEMHRRKY 503

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Query:   10 DIGIKAVEIYFPNTCIDQKDLEESDNC-LGKYTVGLGQIKMGVCSDLEDINSIALTVTKQLLENNFIDPNDIGFLSVGTETLIDKSKSTKTVLMELFEKHGNTDIQGVDEKNACFGGTASLFAALDWLESSNCDGRLXXXXXXXXXXXXXXXXRCTGGAGAVAMLLGPNAPLIFDKGIRSHHMSHQWDFYKPKLDSEYPVYDGQLSIISYQKSIDKCFQLYKKKCLN--KGLINQSMILFRENYYFCFHSPYTKLVEKSFARLVFNDIKDNPDIVEQFNEQLEDIKPFLHLNIENTYGNRDFDLSFLKFSDTLIKDKLRPGVLMAQNNGNMYTASLYGSLISVLIQTPIEELVGSRIVLFSYGSGLASCMFSLMITENKMKLSEIKDSLNKIVD---NLKNRIILSYKEFEDFLARRSSINCKCNVKPSTELSYLRSGTFYLSEIDEKYRRKY 1350
            D+GI A+E+YFP   +DQ DLE+ +N   GKYTVGLGQ +MG CS  EDINS+ LTV ++L+E   +  + +G L VGTET+IDKSK+ KTVLMELF+  GNTDI+G+D  NAC+GGTASLF A +W+ESS  DGR A+VV  DIA+Y    AR TGGAGAVAML+GP APL+ ++G+R  HM + +DFYKP L SEYP+ DG+LSI  Y +++D+C+  Y+KK  N  K   N       +  Y  FH+P+ K+V+KS ARL+FND   +    ++ N   + ++ F  L +E TY N+D D + LK S  +   K +  + ++ NNGNMYT+SLYG L S+L     +EL GSRI  FSYGSGLA+  FS  ++++    S ++  ++ + D    L +R  +S +EF + + +R     K N  P  + S L  GT+YL  +DE +RRKY
Sbjct:   53 DVGILALEVYFPAQYVDQTDLEKFNNVEAGKYTVGLGQTRMGFCSVQEDINSLCLTVVQRLMERTKLPWDAVGRLEVGTETIIDKSKAVKTVLMELFQDSGNTDIEGIDTTNACYGGTASLFNAANWMESSYWDGRYALVVCGDIAVYPSGNARPTGGAGAVAMLIGPKAPLVLEQGLRGTHMENAYDFYKPNLASEYPLVDGKLSIQCYLRALDRCYAAYRKKIQNQWKQAGNNQPFTLDDVQYMIFHTPFCKMVQKSLARLMFNDFLSSSS--DKQNNLYKGLEAFRGLKLEETYTNKDVDKALLKASLDMFNQKTKASLYLSTNNGNMYTSSLYGCLASLLSHHSAQELAGSRIGAFSYGSGLAASFFSFRVSKDASPGSPLEKLVSSVSDLPKRLDSRRRMSPEEFTEIMNQREQFYHKVNFSPPGDTSNLFPGTWYLERVDEMHRRKY 503

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BLAST of 3-hydroxy-3-methylglutaryl coenzyme A synthase vs. Ensembl Mouse
Match: Hmgcs1 (3-hydroxy-3-methylglutaryl-Coenzyme A synthase 1 [Source:MGI Symbol;Acc:MGI:107592])

HSP 1 Score: 388.267 bits (996), Expect = 3.255e-129
Identity = 213/453 (47.02%), Postives = 300/453 (66.23%), Query Frame = 1

Query:   10 DIGIKAVEIYFPNTCIDQKDLEESDNC-LGKYTVGLGQIKMGVCSDLEDINSIALTVTKQLLENNFIDPNDIGFLSVGTETLIDKSKSTKTVLMELFEKHGNTDIQGVDEKNACFGGTASLFAALDWLESSNCDGRLXXXXXXXXXXXXXXXXRCTGGAGAVAMLLGPNAPLIFDKGIRSHHMSHQWDFYKPKLDSEYPVYDGQLSIISYQKSIDKCFQLYKKKCLNKGLINQSMILFREN--YYFCFHSPYTKLVEKSFARLVFNDIKDNPDIVEQFNEQLEDIKPFLHLNIENTYGNRDFDLSFLKFSDTLIKDKLRPGVLMAQNNGNMYTASLYGSLISVLIQTPIEELVGSRIVLFSYGSGLASCMFSLMITENKM---KLSEIKDSLNKIVDNLKNRIILSYKEFEDFLARRSSINCKCNVKPSTELSYLRSGTFYLSEIDEKYRRKY 1350
            D+GI A+EIYFP+  +DQ +LE+ D    GKYT+GLGQ +MG C+D EDINS+ LTV ++L+E + +  + IG L VGTET+IDKSKS K+ LM+LFE+ GNTDI+G+D  NAC+GGTA++F A++W+ESS+ DGR A+VVA DIAIYA   AR TGG GAVA+L+GPNAPLIFD+G+R  HM H +DFYKP + SEYPV DG+LSI  Y  ++D+C+ +Y+KK   +         F  N   +  FHSPY KLV+KS AR+  ND  ++ +     N     ++ F  + +E+TY +RD + +F+K S  L   K +  +L++  NGNMYT+S+YGSL SVL Q   ++L G R+ +FSYGSGLA+ ++SL +T++      L +I  SL  +   L +R  ++   F + +  R   +   N  P   +  L  GT+YL  +DEK+RR Y
Sbjct:   16 DVGIVALEIYFPSQYVDQAELEKYDGVDAGKYTIGLGQARMGFCTDREDINSLCLTVVQKLMERHSLSYDCIGRLEVGTETIIDKSKSVKSNLMQLFEESGNTDIEGIDTTNACYGGTAAVFNAVNWVESSSWDGRYALVVAGDIAIYATGNARPTGGVGAVALLIGPNAPLIFDRGLRGTHMQHAYDFYKPDMLSEYPVVDGKLSIQCYLSALDRCYSVYRKKIRAQWQKEGKDKDFTLNDFGFMIFHSPYCKLVQKSLARMFLNDFLNDQN--RDKNSIYSGLEAFGDVKLEDTYFDRDVEKAFMKASSELFNQKTKASLLVSNQNGNMYTSSVYGSLASVLAQYSPQQLAGKRVGVFSYGSGLAATLYSLKVTQDATPGSALDKITASLCDLKSRLDSRTCVAPDVFAENMKLREDTHHLANYIPQCSIDSLFEGTWYLVRVDEKHRRTY 466

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Query:   10 DIGIKAVEIYFPNTCIDQKDLEESDNC-LGKYTVGLGQIKMGVCSDLEDINSIALTVTKQLLENNFIDPNDIGFLSVGTETLIDKSKSTKTVLMELFEKHGNTDIQGVDEKNACFGGTASLFAALDWLESSNCDGRLXXXXXXXXXXXXXXXXRCTGGAGAVAMLLGPNAPLIFDKGIRSHHMSHQWDFYKPKLDSEYPVYDGQLSIISYQKSIDKCFQLYKKKCLNKGLINQSMILFREN--YYFCFHSPYTKLVEKSFARLVFNDIKDNPDIVEQFNEQLEDIKPFLHLNIENTYGNRDFDLSFLKFSDTLIKDKLRPGVLMAQNNGNMYTASLYGSLISVLIQTPIEELVGSRIVLFSYGSGLASCMFSLMITENKM---KLSEIKDSLNKIVDNLKNRIILSYKEFEDFLARRSSINCKCNVKPSTELSYLRSGTFYLSEIDEKYRRKY 1350
            D+GI A+EIYFP+  +DQ +LE+ D    GKYT+GLGQ +MG C+D EDINS+ LTV ++L+E + +  + IG L VGTET+IDKSKS K+ LM+LFE+ GNTDI+G+D  NAC+GGTA++F A++W+ESS+ DGR A+VVA DIAIYA   AR TGG GAVA+L+GPNAPLIFD+G+R  HM H +DFYKP + SEYPV DG+LSI  Y  ++D+C+ +Y+KK   +         F  N   +  FHSPY KLV+KS AR+  ND  ++ +     N     ++ F  + +E+TY +RD + +F+K S  L   K +  +L++  NGNMYT+S+YGSL SVL Q   ++L G R+ +FSYGSGLA+ ++SL +T++      L +I  SL  +   L +R  ++   F + +  R   +   N  P   +  L  GT+YL  +DEK+RR Y
Sbjct:   16 DVGIVALEIYFPSQYVDQAELEKYDGVDAGKYTIGLGQARMGFCTDREDINSLCLTVVQKLMERHSLSYDCIGRLEVGTETIIDKSKSVKSNLMQLFEESGNTDIEGIDTTNACYGGTAAVFNAVNWVESSSWDGRYALVVAGDIAIYATGNARPTGGVGAVALLIGPNAPLIFDRGLRGTHMQHAYDFYKPDMLSEYPVVDGKLSIQCYLSALDRCYSVYRKKIRAQWQKEGKDKDFTLNDFGFMIFHSPYCKLVQKSLARMFLNDFLNDQN--RDKNSIYSGLEAFGDVKLEDTYFDRDVEKAFMKASSELFNQKTKASLLVSNQNGNMYTSSVYGSLASVLAQYSPQQLAGKRVGVFSYGSGLAATLYSLKVTQDATPGSALDKITASLCDLKSRLDSRTCVAPDVFAENMKLREDTHHLANYIPQCSIDSLFEGTWYLVRVDEKHRRTY 466

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BLAST of 3-hydroxy-3-methylglutaryl coenzyme A synthase vs. UniProt/SwissProt
Match: sp|P54869|HMCS2_MOUSE (Hydroxymethylglutaryl-CoA synthase, mitochondrial OS=Mus musculus OX=10090 GN=Hmgcs2 PE=1 SV=2)

HSP 1 Score: 396.356 bits (1017), Expect = 1.011e-131
Identity = 214/453 (47.24%), Postives = 296/453 (65.34%), Query Frame = 1

Query:   10 DIGIKAVEIYFPNTCIDQKDLEESDNC-LGKYTVGLGQIKMGVCSDLEDINSIALTVTKQLLENNFIDPNDIGFLSVGTETLIDKSKSTKTVLMELFEKHGNTDIQGVDEKNACFGGTASLFAALDWLESSNCDGRLXXXXXXXXXXXXXXXXRCTGGAGAVAMLLGPNAPLIFDKGIRSHHMSHQWDFYKPKLDSEYPVYDGQLSIISYQKSIDKCFQLYKKKCLN--KGLINQSMILFRENYYFCFHSPYTKLVEKSFARLVFNDIKDNPDIVEQFNEQLEDIKPFLHLNIENTYGNRDFDLSFLKFSDTLIKDKLRPGVLMAQNNGNMYTASLYGSLISVLIQTPIEELVGSRIVLFSYGSGLASCMFSLMITENKMKLSEIKDSLNKIVD---NLKNRIILSYKEFEDFLARRSSINCKCNVKPSTELSYLRSGTFYLSEIDEKYRRKY 1350
            D+GI A+E+YFP   +DQ DLE+ +N   GKYTVGLGQ +MG CS  EDINS+ LTV ++L+E   +  + +G L VGTET+IDKSK+ KTVLMELF+  GNTDI+G+D  NAC+GGTASLF A +W+ESS  DGR A+VV  DIA+Y    AR TGGAGAVAML+GP APL+ ++G+R  HM + +DFYKP L SEYP+ DG+LSI  Y +++D+C+  Y+KK  N  K   N       +  Y  FH+P+ K+V+KS ARL+FND   +    ++ N   + ++ F  L +E TY N+D D + LK S  +   K +  + ++ NNGNMYT+SLYG L S+L     +EL GSRI  FSYGSGLA+  FS  ++++    S ++  ++ + D    L +R  +S +EF + + +R     K N  P  + S L  GT+YL  +DE +RRKY
Sbjct:   53 DVGILALEVYFPAQYVDQTDLEKFNNVEAGKYTVGLGQTRMGFCSVQEDINSLCLTVVQRLMERTKLPWDAVGRLEVGTETIIDKSKAVKTVLMELFQDSGNTDIEGIDTTNACYGGTASLFNAANWMESSYWDGRYALVVCGDIAVYPSGNARPTGGAGAVAMLIGPKAPLVLEQGLRGTHMENAYDFYKPNLASEYPLVDGKLSIQCYLRALDRCYAAYRKKIQNQWKQAGNNQPFTLDDVQYMIFHTPFCKMVQKSLARLMFNDFLSSSS--DKQNNLYKGLEAFRGLKLEETYTNKDVDKALLKASLDMFNQKTKASLYLSTNNGNMYTSSLYGCLASLLSHHSAQELAGSRIGAFSYGSGLAASFFSFRVSKDASPGSPLEKLVSSVSDLPKRLDSRRRMSPEEFTEIMNQREQFYHKVNFSPPGDTSNLFPGTWYLERVDEMHRRKY 503

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BLAST of 3-hydroxy-3-methylglutaryl coenzyme A synthase vs. UniProt/SwissProt
Match: sp|P22791|HMCS2_RAT (Hydroxymethylglutaryl-CoA synthase, mitochondrial OS=Rattus norvegicus OX=10116 GN=Hmgcs2 PE=1 SV=1)

HSP 1 Score: 394.43 bits (1012), Expect = 5.407e-131
Identity = 212/453 (46.80%), Postives = 295/453 (65.12%), Query Frame = 1

Query:   10 DIGIKAVEIYFPNTCIDQKDLEESDNC-LGKYTVGLGQIKMGVCSDLEDINSIALTVTKQLLENNFIDPNDIGFLSVGTETLIDKSKSTKTVLMELFEKHGNTDIQGVDEKNACFGGTASLFAALDWLESSNCDGRLXXXXXXXXXXXXXXXXRCTGGAGAVAMLLGPNAPLIFDKGIRSHHMSHQWDFYKPKLDSEYPVYDGQLSIISYQKSIDKCFQLYKKKCLN--KGLINQSMILFRENYYFCFHSPYTKLVEKSFARLVFNDIKDNPDIVEQFNEQLEDIKPFLHLNIENTYGNRDFDLSFLKFSDTLIKDKLRPGVLMAQNNGNMYTASLYGSLISVLIQTPIEELVGSRIVLFSYGSGLASCMFSLMITENKMKLSEIKDSLNKIVD---NLKNRIILSYKEFEDFLARRSSINCKCNVKPSTELSYLRSGTFYLSEIDEKYRRKY 1350
            D+GI A+E+YFP   +DQ DLE+ +N   GKYTVGLGQ +MG CS  EDINS+ LTV ++L+E   +  + +G L VGTET+IDKSK+ KTVLMELF+  GNTDI+G+D  NAC+GGTASLF A +W+ESS  DGR A+VV  DIA+Y     R TGGAGAVAML+GP APL+ ++G+R  HM + +DFYKP L SEYP+ DG+LSI  Y +++D+C+  Y++K  N  K   N       +  Y  FH+P+ K+V+KS ARL+FND   +    ++ N   + ++ F  L +E TY N+D D + LK S  +   K +  + ++ NNGNMYT+SLYG L S+L     +EL GSRI  FSYGSGLA+  FS  ++++    S ++  ++ + D    L +R  +S +EF + + +R     K N  P  + S L  GT+YL  +DE +RRKY
Sbjct:   53 DVGILALEVYFPAQYVDQTDLEKFNNVEAGKYTVGLGQTRMGFCSVQEDINSLCLTVVQRLMERTKLPWDAVGRLEVGTETIIDKSKAVKTVLMELFQDSGNTDIEGIDTTNACYGGTASLFNAANWMESSYWDGRYALVVCGDIAVYPSGNPRPTGGAGAVAMLIGPKAPLVLEQGLRGTHMENAYDFYKPNLASEYPLVDGKLSIQCYLRALDRCYAAYRRKIQNQWKQAGNNQPFTLDDVQYMIFHTPFCKMVQKSLARLMFNDFLSSSS--DKQNNLYKGLEAFKGLKLEETYTNKDVDKALLKASLDMFNKKTKASLYLSTNNGNMYTSSLYGCLASLLSHHSAQELAGSRIGAFSYGSGLAASFFSFRVSKDASPGSPLEKLVSSVSDLPKRLDSRRRMSPEEFTEIMNQREQFYHKVNFSPPGDTSNLFPGTWYLERVDEMHRRKY 503

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BLAST of 3-hydroxy-3-methylglutaryl coenzyme A synthase vs. UniProt/SwissProt
Match: sp|P54868|HMCS2_HUMAN (Hydroxymethylglutaryl-CoA synthase, mitochondrial OS=Homo sapiens OX=9606 GN=HMGCS2 PE=1 SV=1)

HSP 1 Score: 391.734 bits (1005), Expect = 7.250e-130
Identity = 214/454 (47.14%), Postives = 297/454 (65.42%), Query Frame = 1

Query:   10 DIGIKAVEIYFPNTCIDQKDLEESDNC-LGKYTVGLGQIKMGVCSDLEDINSIALTVTKQLLENNFIDPNDIGFLSVGTETLIDKSKSTKTVLMELFEKHGNTDIQGVDEKNACFGGTASLFAALDWLESSNCDGRLXXXXXXXXXXXXXXXXRCTGGAGAVAMLLGPNAPLIFDKGIRSHHMSHQWDFYKPKLDSEYPVYDGQLSIISYQKSIDKCFQLYKKKCLNKGLINQSMILFREN--YYFCFHSPYTKLVEKSFARLVFND-IKDNPDIVEQFNEQLEDIKPFLHLNIENTYGNRDFDLSFLKFSDTLIKDKLRPGVLMAQNNGNMYTASLYGSLISVLIQTPIEELVGSRIVLFSYGSGLASCMFSLMITENKM---KLSEIKDSLNKIVDNLKNRIILSYKEFEDFLARRSSINCKCNVKPSTELSYLRSGTFYLSEIDEKYRRKY 1350
            D+GI A+E+YFP   +DQ DLE+ +N   GKYTVGLGQ +MG CS  EDINS+ LTV ++L+E   +  + +G L VGTET+IDKSK+ KTVLMELF+  GNTDI+G+D  NAC+GGTASLF A +W+ESS+ DGR A+VV  DIA+Y    AR TGGAGAVAML+GP APL  ++G+R  HM + +DFYKP L SEYP+ DG+LSI  Y +++D+C+  Y+KK  N+     S   F  +   Y  FH+P+ K+V+KS ARL+FND +  + D      + LE    F  L +E+TY N+D D + LK S  +   K +  + ++ +NGNMYT+SLYG L S+L     +EL GSRI  FSYGSGLA+  FS  ++++      L ++  S + +   L +R  +S +EF + + +R     K N  P  + + L  GT+YL  +DE++RRKY
Sbjct:   53 DVGILALEVYFPAQYVDQTDLEKYNNVEAGKYTVGLGQTRMGFCSVQEDINSLCLTVVQRLMERIQLPWDSVGRLEVGTETIIDKSKAVKTVLMELFQDSGNTDIEGIDTTNACYGGTASLFNAANWMESSSWDGRYAMVVCGDIAVYPSGNARPTGGAGAVAMLIGPKAPLALERGLRGTHMENVYDFYKPNLASEYPIVDGKLSIQCYLRALDRCYTSYRKKIQNQWKQAGSDRPFTLDDLQYMIFHTPFCKMVQKSLARLMFNDFLSASSDTQTSLYKGLE---AFGGLKLEDTYTNKDLDKALLKASQDMFDKKTKASLYLSTHNGNMYTSSLYGCLASLLSHHSAQELAGSRIGAFSYGSGLAASFFSFRVSQDAAPGSPLDKLVSSTSDLPKRLASRKCVSPEEFTEIMNQREQFYHKVNFSPPGDTNSLFPGTWYLERVDEQHRRKY 503

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BLAST of 3-hydroxy-3-methylglutaryl coenzyme A synthase vs. UniProt/SwissProt
Match: sp|P23228|HMCS1_CHICK (Hydroxymethylglutaryl-CoA synthase, cytoplasmic OS=Gallus gallus OX=9031 GN=HMGCS1 PE=1 SV=1)

HSP 1 Score: 391.349 bits (1004), Expect = 1.507e-129
Identity = 216/453 (47.68%), Postives = 298/453 (65.78%), Query Frame = 1

Query:   10 DIGIKAVEIYFPNTCIDQKDLEESDNC-LGKYTVGLGQIKMGVCSDLEDINSIALTVTKQLLENNFIDPNDIGFLSVGTETLIDKSKSTKTVLMELFEKHGNTDIQGVDEKNACFGGTASLFAALDWLESSNCDGRLXXXXXXXXXXXXXXXXRCTGGAGAVAMLLGPNAPLIFDKGIRSHHMSHQWDFYKPKLDSEYPVYDGQLSIISYQKSIDKCFQLYKKKCLNKGLINQSMILFREN--YYFCFHSPYTKLVEKSFARLVFNDIKDNPDIVEQFNEQLEDIKPFLHLNIENTYGNRDFDLSFLKFSDTLIKDKLRPGVLMAQNNGNMYTASLYGSLISVLIQTPIEELVGSRIVLFSYGSGLASCMFSLMITENKM---KLSEIKDSLNKIVDNLKNRIILSYKEFEDFLARRSSINCKCNVKPSTELSYLRSGTFYLSEIDEKYRRKY 1350
            D+GI A+EIYFP+  +DQ +LE+ D    GKYT+GLGQ KMG CSD EDINS+ LTV ++L+E N +  + IG L VGTET+IDKSKS KTVLM+LFE+ GNTD++G+D  NAC+GGTA+LF A++W+ESS+ DGR A+VVA DIA+YA   AR TGGAGAVAML+G NAPLIF++G+R  HM H +DFYKP + SEYPV DG+LSI  Y  ++D+C+ +Y+ K   +     +   F  N   +  FHSPY KLV+KS ARL+ ND   + +  E  N     ++ F  + +E+TY +RD + +F+K S  L   K +  +L++  NGNMYT S+YG L S+L Q   E L G RI  FSYGSG A+ ++S+ +T++      L +I  SL+ +   L +R  ++   F + +  R   +   N  P   +  L  GT+YL  +DEK+RR Y
Sbjct:   16 DVGIVALEIYFPSQYVDQTELEKYDGVDAGKYTIGLGQSKMGFCSDREDINSLCLTVVQKLMERNSLSYDCIGRLEVGTETIIDKSKSVKTVLMQLFEESGNTDVEGIDTTNACYGGTAALFNAINWIESSSWDGRYALVVAGDIAVYATGNARPTGGAGAVAMLVGSNAPLIFERGLRGTHMQHAYDFYKPDMVSEYPVVDGKLSIQCYLSALDRCYSVYRNKIHAQWQKEGTDRGFTLNDFGFMIFHSPYCKLVQKSVARLLLNDFLSDQN-AETANGVFSGLEAFRDVKLEDTYFDRDVEKAFMKASAELFNQKTKASLLVSNQNGNMYTPSVYGCLASLLAQYSPEHLAGQRISEFSYGSGFAATLYSIRVTQDATPGSALDKITASLSDLKARLDSRKCIAPDVFAENMKIRQETHHLANYIPQCSVEDLFEGTWYLVRVDEKHRRTY 467

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BLAST of 3-hydroxy-3-methylglutaryl coenzyme A synthase vs. UniProt/SwissProt
Match: sp|P54961|HMCS1_BLAGE (Hydroxymethylglutaryl-CoA synthase 1 OS=Blattella germanica OX=6973 GN=HMGCS-1 PE=2 SV=1)

HSP 1 Score: 386.726 bits (992), Expect = 1.089e-128
Identity = 217/456 (47.59%), Postives = 297/456 (65.13%), Query Frame = 1

Query:   10 DIGIKAVEIYFPNTCIDQKDLEESDNC-LGKYTVGLGQIKMGVCSDLEDINSIALTVTKQLLENNFIDPNDIGFLSVGTETLIDKSKSTKTVLMELFEKHGNTDIQGVDEKNACFGGTASLFAALDWLESSNCDGRLXXXXXXXXXXXXXXXXRCTGGAGAVAMLLGPNAPLIFDKGIRSHHMSHQWDFYKPKLDSEYPVYDGQLSIISYQKSIDKCFQLYKKKCLNKGLINQSMILFRENYYFCFHSPYTKLVEKSFARLVFNDIKDNPDIVEQFNEQLEDIKPFLHLNIENTYGNRDFDLSFLKFSDTLIKDKLRPGVLMAQNNGNMYTASLYGSLISVLIQTPIEELVGSRIVLFSYGSGLASCMFSLMITENKMKLSEIKDSLNKIVDNLKN-------RIILSYKEFEDFLARRSSINCKCNVKPSTELSYLRSGTFYLSEIDEKYRRKYQ 1353
            D+GI A+E+ FP+  +DQ DLE  DN   GKYTVGLGQ +MG C+D EDINS+ LTV  +L+E   I  + IG L VGTETL+DKSKS KTVLM+LF+   NTDI+GVD  NAC+GGT++LF A+ W+ESS+ DGR A+VVA DIA+YA+ +AR TGGAGAVAML+G NAPL+FD+G+RS HM H +DFYKP L S YP  DG+LSI  Y  ++D C+QLY  K   +  + +   + R +    FH+PY KLV+KS ARLV ND     +  E+   +   ++    + +E+TY +R+ + + + +S  + ++K +P +L+A   GNMYT SLYG L+S+L+    +EL G R+ LFSYGSGLAS MFSL I+ +    +  K SL ++V NL +       R  +S +EF   +  R   + K    P   +  L  GT+YL  +D  YRR Y+
Sbjct:    5 DVGIVALELIFPSQYVDQVDLEVYDNVSAGKYTVGLGQARMGFCTDREDINSLCLTVVSRLMERWSIPYSQIGRLEVGTETLLDKSKSVKTVLMQLFKD--NTDIEGVDTVNACYGGTSALFNAISWVESSSWDGRYALVVAGDIAVYAKGSARPTGGAGAVAMLVGANAPLVFDRGVRSSHMQHAYDFYKPDLSSLYPTVDGKLSIQCYLSALDHCYQLYCSKIQKQ--LGEKFDIERLDAVL-FHAPYCKLVQKSLARLVLNDFVRASE--EERTTKYSSLEALKGVKLEDTYFDREVEKAVMTYSKNMFEEKTKPSLLLANQVGNMYTPSLYGGLVSLLVSKSAQELAGKRVALFSYGSGLASSMFSLRISSD----ASAKSSLQRLVSNLSHIKPQLDLRHKVSPEEFAQTMETREHNHHKAPYTPEGSIDVLFPGTWYLESVDSLYRRSYK 449

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BLAST of 3-hydroxy-3-methylglutaryl coenzyme A synthase vs. TrEMBL
Match: K1PE75 (3-hydroxy-3-methylglutaryl coenzyme A synthase OS=Crassostrea gigas OX=29159 GN=CGI_10002659 PE=3 SV=1)

HSP 1 Score: 429.098 bits (1102), Expect = 2.040e-142
Identity = 229/460 (49.78%), Postives = 315/460 (68.48%), Query Frame = 1

Query:   10 DIGIKAVEIYFPNTCIDQKDLEESDNC-LGKYTVGLGQIKMGVCSDLEDINSIALTVTKQLLENNFIDPNDIGFLSVGTETLIDKSKSTKTVLMELFEKHGNTDIQGVDEKNACFGGTASLFAALDWLESSNCDGRLXXXXXXXXXXXXXXXXRCTGGAGAVAMLLGPNAPLIFDKGIRSHHMSHQWDFYKPKLDSEYPVYDGQLSIISYQKSIDKCFQLYKKKCLNKGLINQSMILFRENYYFCFHSPYTKLVEKSFARLVFNDIKDNPDIVEQFNEQLEDIKPFLHLNIENTYGNRDFDLSFLKFSDTLIKDKLRPGVLMAQNNGNMYTASLYGSLISVLIQTPIEELVGSRIVLFSYGSGLASCMFSLMITEN-KMKLSEIKDSLNKIVDNLKNRIILSYKEFEDFLARRSSINCKCNVKPSTELSYLRSGTFYLSEIDEKYRRKY-QIYNSEITNG 1380
            D+GI A+E+YFP+  +DQ +LE  D    GKYT+GLGQ KMG CSD EDINS+ LTV ++L+E N +  NDIG L VGTET+IDKSKSTKTVLM+LFE  GN  ++G+D  NACFGGT++LF A++W+ESS+ DGR A+VVA DIA+YA   ARCTGGAGAVAML+G  APL+FD+G+RS +M H +DFYKP +DSEYPV DG+LS+  Y  ++DKC+Q Y +K    G+  +   L   +  F FHSPY KLV+KSFAR+  ND    P     F+ +   ++   +L +E +Y +RD + + +  S++L   K +P +L+A   GNMYT S+YG L S L+     ELVG RIVLFSYGSGLAS MFS+ IT++   KL+++ ++L+ I  NL+NR+ +S +EF+  +  R   + +    P      L  GT++L+E+D  +RRKY ++   +I NG
Sbjct:   13 DVGIVAMEVYFPSQYVDQAELEIFDKVSTGKYTIGLGQAKMGFCSDREDINSLCLTVVQKLIEKNDLSYNDIGRLEVGTETIIDKSKSTKTVLMQLFESSGNYSVEGIDTTNACFGGTSALFNAVNWIESSSWDGRYALVVAGDIAVYATGNARCTGGAGAVAMLIGSEAPLVFDRGVRSIYMQHAYDFYKPNMDSEYPVVDGKLSVKCYLHALDKCYQAYTEKATQTGIKGKEDNLINSSDAFVFHSPYCKLVQKSFARIFLNDFLQEPS--PDFSGRYAGLESLRNLKLEESYFDRDAEKALMAASNSLFTLKTKPSLLLANQVGNMYTPSVYGGLASYLLSASPSELVGHRIVLFSYGSGLASAMFSIKITKDLGPKLNKLLENLSNITKNLQNRVKVSPEEFDKTMKLREETHNRAPYTPVGSTEGLFPGTWFLTEVDTMHRRKYDRVPLVQIPNG 470

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BLAST of 3-hydroxy-3-methylglutaryl coenzyme A synthase vs. TrEMBL
Match: A0A0B7AGV3 (3-hydroxy-3-methylglutaryl coenzyme A synthase OS=Arion vulgaris OX=1028688 GN=ORF113877 PE=3 SV=1)

HSP 1 Score: 415.231 bits (1066), Expect = 8.795e-137
Identity = 227/463 (49.03%), Postives = 306/463 (66.09%), Query Frame = 1

Query:   10 DIGIKAVEIYFPNTCIDQKDLEESDNC-LGKYTVGLGQIKMGVCSDLEDINSIALTVTKQLLENNFIDPNDIGFLSVGTETLIDKSKSTKTVLMELFEKHGNTDIQGVDEKNACFGGTASLFAALDWLESSNCDGRLXXXXXXXXXXXXXXXXRCTGGAGAVAMLLGPNAPLIFDKGIRSHHMSHQWDFYKPKLDSEYPVYDGQLSIISYQKSIDKCFQLYKKKCLNKGLINQSMILFRENYYFCFHSPYTKLVEKSFARLVFNDI--KDNPDIVEQFNEQLEDIKPFLHLNIENTYGNRDFDLSFLKFSDTLIKDKLRPGVLMAQNNGNMYTASLYGSLISVLIQTPIEELVGSRIVLFSYGSGLASCMFSLMITENKM---KLSEIKDSLNKIVDNLKNRIILSYKEFEDFLARRSSINCKCNVKPSTELSYLRSGTFYLSEIDEKYRRKYQIYNSEITNG 1380
            D+GI A+EIYFP+  +DQ  LE  D    GKYT+GLGQ KMG CSD EDINS+ LTV ++L+E N I+  DIG L VGTET+IDKSKSTK+VLM+LFE  GNTD++GVD  NAC+GGT++LF A++W+ESS+ DGR A+VVA DIA+YA   ARCTGGAGAVAML+GP APLIFD+G+RS HM H +DFYKP + SEYPV DG+LSI  Y  S+D C++ Y  K +  GL   S +   +   F FHSPY KLV+KSFARL+ ND     NPD+  ++      ++ F  + +E TY +R  +++ L  S  L   K +P +L+A   GNMYT SLYG L S +       + G R+V FSYGSGLAS MFS+  T++     +L  + +SL+ +   L++R  +  +EF+  +  R   +     KP   +S L   T++L+E+D  +RRKY   +  +T+G
Sbjct:   16 DVGILALEIYFPSQYVDQTQLESFDEVSAGKYTIGLGQSKMGFCSDREDINSLCLTVVQKLMERNAINYMDIGRLEVGTETIIDKSKSTKSVLMQLFEDSGNTDVEGVDTTNACYGGTSALFNAVNWVESSSWDGRYALVVAGDIAVYATGNARCTGGAGAVAMLIGPEAPLIFDRGVRSSHMQHVYDFYKPDMASEYPVVDGKLSIQCYLHSLDVCYERYTTKSIAAGLRGDSTLDVGDA--FIFHSPYCKLVQKSFARLLLNDFLRNKNPDLAGRY----AGLETFRDVKLEETYFDRSVEVAALSTSQALFDAKTKPTLLVANQVGNMYTPSLYGGLCSYICGLTTASIAGKRVVFFSYGSGLASSMFSMKFTDSNAPGSQLDRLVNSLSDLKHRLESRQCVPPEEFDKIMKLREQTHHLAPYKPVGSVSALFPDTWHLTEVDSMHRRKYTCSHLNLTDG 472

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BLAST of 3-hydroxy-3-methylglutaryl coenzyme A synthase vs. TrEMBL
Match: A0A0J7N5E3 (3-hydroxy-3-methylglutaryl coenzyme A synthase OS=Lasius niger OX=67767 GN=RF55_12678 PE=3 SV=1)

HSP 1 Score: 412.149 bits (1058), Expect = 4.033e-136
Identity = 221/453 (48.79%), Postives = 301/453 (66.45%), Query Frame = 1

Query:   10 DIGIKAVEIYFPNTCIDQKDLEESDNC-LGKYTVGLGQIKMGVCSDLEDINSIALTVTKQLLENNFIDPNDIGFLSVGTETLIDKSKSTKTVLMELFEKHGNTDIQGVDEKNACFGGTASLFAALDWLESSNCDGRLXXXXXXXXXXXXXXXXRCTGGAGAVAMLLGPNAPLIFDKGIRSHHMSHQWDFYKPKLDSEYPVYDGQLSIISYQKSIDKCFQLYKKKCLNKGLINQSMILFRENYYFCFHSPYTKLVEKSFARLVFNDIKDNPDIVEQFNEQLEDIKPFLHLNIENTYGNRDFDLSFLKFSDTLIKDKLRPGVLMAQNNGNMYTASLYGSLISVLIQTPIEELVGSRIVLFSYGSGLASCMFSLMITENKMK---LSEIKDSLNKIVDNLKNRIILSYKEFEDFLARRSSINCK-CNVKPSTELSYLRSGTFYLSEIDEKYRRKYQ 1353
            D+GI+A+E+YFP   +DQ +LE  +    GKYT+GLGQ +MG C+D EDINS+ LTVT +LLE   I+P DIG L VGTET++DKSKS K+VLM+LFE HG TDI+G D  NAC+GGTA+LF A  W+ESS  +G+LA+VVAAD A+Y+  +AR TGGAGA+A+L+GP+APL+FD+G+R+  M H +DFYKP L SEYPV DG+LSI  Y  ++D C+QLY  K   KGL     +       F FHSPY KLV+KSFARL F D  + P      +E+ +D        +E+TY +RD +  F + S T  + K +P +L+A   GNMYT S+Y  L+S+L+  PI EL G++I LFSYGSG  S M+SL +T +      LS+I  +L+ +   L+ R  +S  ++   LA R   NC      P + +  +  GT+YL+++DEKYRR Y+
Sbjct:    5 DVGIRALEVYFPAQYVDQTELEAYNGVSAGKYTIGLGQSRMGFCNDREDINSLCLTVTHRLLERYGIEPRDIGRLEVGTETILDKSKSVKSVLMQLFEPHGCTDIEGADATNACYGGTAALFNAAAWIESSAWNGKLALVVAADNAVYSAGSARPTGGAGAIAILVGPDAPLVFDRGLRASCMRHAYDFYKPDLRSEYPVVDGKLSIQCYLSALDSCYQLYCDKVREKGLAGDDPVTLANFDAFLFHSPYCKLVQKSFARLAFVDFLNTPKERICNDERYKDAVSLHAAKLEDTYFDRDIEKVFTRLSKTDFERKTKPSLLIANQVGNMYTPSVYSGLVSLLLSKPISELAGNKIALFSYGSGFCSSMYSLTVTRDTRDGSGLSKIIAALSYVKPQLEGRHCVSPADYTRVLALREQ-NCHVVPFTPESNIDDMFPGTYYLTQVDEKYRRTYE 456

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BLAST of 3-hydroxy-3-methylglutaryl coenzyme A synthase vs. TrEMBL
Match: A0A3S3NZT7 (3-hydroxy-3-methylglutaryl coenzyme A synthase (Fragment) OS=Dinothrombium tinctorium OX=1965070 GN=B4U79_01775 PE=3 SV=1)

HSP 1 Score: 412.92 bits (1060), Expect = 4.285e-136
Identity = 224/462 (48.48%), Postives = 315/462 (68.18%), Query Frame = 1

Query:   10 DIGIKAVEIYFPNTCIDQKDLEESDNCL-GKYTVGLGQIKMGVCSDLEDINSIALTVTKQLLENNFIDPNDIGFLSVGTETLIDKSKSTKTVLMELFEKHGNTDIQGVDEKNACFGGTASLFAALDWLESSNCDGRLXXXXXXXXXXXXXXXXRCTGGAGAVAMLLGPNAPLIFDKGIRSHHMSHQWDFYKPKLDSEYPVYDGQLSIISYQKSIDKCFQLYKKKCLNKGLINQSMILFRENYYFCFHSPYTKLVEKSFARLVFNDI--KDNPDIVEQFNEQLEDIKPFLHLNIENTYGNRDFDLSFLKFSDTLIKDKLRPGVLMAQNNGNMYTASLYGSLISVLIQTPIEELVGSRIVLFSYGSGLASCMFSLMITENK---MKLSEIKDSLNKIVDNLKNRIILSYKEFEDFLARRSSINCKCNVKPSTELSYLRSGTFYLSEIDEKYRRKYQIYNSEITN 1377
            DIGI AVE+YFP+T +DQ +LE+ D    GKYT+GLGQ +MG CSD EDINS+ LTVTK LLE + + P DIGFL VGTET++DKSKS K+VLM+LF + GN+DI G+D  NAC+GGTA+LF A+DW+ESSN DGR AIVVA DIAIY+E  AR TGGAGAVAML+GPNAPL+ ++G+R+ HM+H +DFYKP LDSEYPV DG+LS++ Y + +DKC+Q+++ K   + +IN+++ L  +      HSPY KLV+KS ARL+FN+   +  PD  + F   LE +K    L +E+TY ++  + +F+K S  L  +K +P + ++   GNMYTASLY  L+S L+  P+ +L G R +LFSYGSG+A+ M+++ IT +      L  +   +  +  ++  R+ +  KEF D L  R          P   +  +  GT+YL+ +D+ YRR+Y+    ++ N
Sbjct:   30 DIGILAVEMYFPSTFVDQSELEQFDGVSSGKYTIGLGQTRMGFCSDREDINSLCLTVTKALLEKSAVSPKDIGFLMVGTETVVDKSKSVKSVLMQLFVESGNSDILGLDTTNACYGGTAALFHAVDWIESSNWDGRYAIVVAGDIAIYSEGNARPTGGAGAVAMLVGPNAPLVLERGMRATHMAHVYDFYKPILDSEYPVVDGKLSVVCYTECVDKCYQVFRNKY--EKVINKTLSL-NDFDGILLHSPYCKLVQKSIARLLFNEFLREPKPDF-QGFYSGLESMK---TLKLEDTYFDKGVESTFVKLSTNLFNEKTKPSLFLSTEVGNMYTASLYSCLVSYLLSKPLNKLEGKRALLFSYGSGMAASMYTIKITNDSSPGSPLDRLYQGIKDVHTHISQRVKVPPKEFVDILKLREGSLHAAPYTPKGTVDNMFPGTYYLTSVDKMYRREYERVPKKVAN 484

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BLAST of 3-hydroxy-3-methylglutaryl coenzyme A synthase vs. TrEMBL
Match: A0A195EGG4 (3-hydroxy-3-methylglutaryl coenzyme A synthase OS=Trachymyrmex cornetzi OX=471704 GN=ALC57_03585 PE=3 SV=1)

HSP 1 Score: 411.764 bits (1057), Expect = 4.637e-136
Identity = 225/455 (49.45%), Postives = 304/455 (66.81%), Query Frame = 1

Query:   10 DIGIKAVEIYFPNTCIDQKDLEESDN-CLGKYTVGLGQIKMGVCSDLEDINSIALTVTKQLLENNFIDPNDIGFLSVGTETLIDKSKSTKTVLMELFEKHGNTDIQGVDEKNACFGGTASLFAALDWLESSNCDGRLXXXXXXXXXXXXXXXXRCTGGAGAVAMLLGPNAPLIFDKGIRSHHMSHQWDFYKPKLDSEYPVYDGQLSIISYQKSIDKCFQLYKKKCLNKGLINQSMILFRENYYFCFHSPYTKLVEKSFARLVFNDIKDNPDIVEQFNEQLEDIKPFLHLNIENTYGNRDFDLSFLKFSDTLIKDKLRPGVLMAQNNGNMYTASLYGSLISVLIQTPIEELVGSRIVLFSYGSGLASCMFSLMI---TENKMKLSEIKDSLNKIVDNLKNRIILSYKEFEDFLARRSSINCKCNVKPSTELSYLR---SGTFYLSEIDEKYRRKYQ 1353
            D+GI+A+E+YFP   ++QK+LE  D    GKYT+GLGQ +MG C+D EDINS+ LTVT +LLE   I P DIG L VGTET+IDKSKS KTVLM+LFE HG TDI+G D  NAC+GGTA+LF A+ W+ESS  DGR A+VVAAD A+Y+  +AR TGGAGA+AML+GP+APL+FD+G+R+  M H +DFYKP + SEYP  DG+LSI  Y  S+D C+QLY++K   K      + L   +    FHSPY KLV+KSFARL F D  + P+   Q  +  +D   F    +E+TY  +D +  F++ S    + K +P +L+A   GNMYT S+Y  L+S+LI  PI EL G+++ +FSYGSGL S ++SL I   T     LS+I  +L+ +   L+ R  +S K++ + LA R      C+V P T  S +     GTFYL+++DE+YRR Y+
Sbjct:    5 DVGIRALEVYFPAQYVEQKELEVYDGMSAGKYTIGLGQSRMGFCNDREDINSLCLTVTSRLLERYEIKPQDIGRLEVGTETIIDKSKSVKTVLMQLFEPHGCTDIEGADTTNACYGGTAALFNAIAWVESSAWDGRFALVVAADNAVYSTGSARPTGGAGAIAMLVGPDAPLVFDRGLRASCMRHAYDFYKPNMRSEYPTVDGKLSIQCYLSSLDNCYQLYREKVKRKSPGENPVTLTNFDAML-FHSPYCKLVQKSFARLAFIDFLNTPE--NQIPDNYKDAVKFHAAKLEDTYFKQDIEKMFIQLSKADFEQKTQPSLLIANQVGNMYTPSVYSGLVSLLISKPISELAGNKVGIFSYGSGLCSSLYSLTIARDTHEGSGLSKIISALSYVKSQLEGRHCVSPKDYTEVLASRER---NCHVVPFTPQSSIVDMFPGTFYLTQVDEQYRRTYK 453

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BLAST of 3-hydroxy-3-methylglutaryl coenzyme A synthase vs. Ensembl Cavefish
Match: hmgcs1 (hydroxymethylglutaryl-CoA synthase, cytoplasmic-like [Source:NCBI gene;Acc:103042817])

HSP 1 Score: 398.282 bits (1022), Expect = 3.004e-133
Identity = 215/455 (47.25%), Postives = 303/455 (66.59%), Query Frame = 1

Query:   10 DIGIKAVEIYFPNTCIDQKDLEESDNC-LGKYTVGLGQIKMGVCSDLEDINSIALTVTKQLLENNFIDPNDIGFLSVGTETLIDKSKSTKTVLMELFEKHGNTDIQGVDEKNACFGGTASLFAALDWLESSNCDGRLXXXXXXXXXXXXXXXXRCTGGAGAVAMLLGPNAPLIFDKGIRSHHMSHQWDFYKPKLDSEYPVYDGQLSIISYQKSIDKCFQLYKKK----CLNKGLINQSMILFRENYYFCFHSPYTKLVEKSFARLVFNDIKDNPDIVEQFNEQLEDIKPFLHLNIENTYGNRDFDLSFLKFSDTLIKDKLRPGVLMAQNNGNMYTASLYGSLISVLIQTPIEELVGSRIVLFSYGSGLASCMFSLMITENKM---KLSEIKDSLNKIVDNLKNRIILSYKEFEDFLARRSSINCKCNVKPSTELSYLRSGTFYLSEIDEKYRRKY 1350
            D+GI A+E+Y P+  +DQ +LEE D    GKYT+GLGQ +MG CSD EDINS+ LTV +QL+E N +  + +G L VGTET+IDKSKS KTVLM+LFE+ GNTD++G+D  NAC+GGTA+LF A++W+ESS+ DGR A+VVA DIA+YA  +AR TGGAGAVAML+GPNAPL FD+G+R  HM H +DFYKP + SEYPV DG+LSI  Y  ++D+C+ +Y+ K       +GL  +      E  Y  FHSPY KLV+KS ARL+ ND   +P    + +     ++ F  + IE+TY +RD + +F+K S  + + K +  +L++  NGNMYT S+YG L SVL Q   +++ G RI +FSYGSG A+ ++S+ +T++      L ++  SL+ +   L +R  ++   F D +  R   +   N  P   +  L  GT+YL+ +DEK+RR Y
Sbjct:   16 DVGIIAMEVYIPSQYVDQTELEEFDGVGAGKYTIGLGQAQMGFCSDREDINSLCLTVVQQLMERNCLSYDSVGRLEVGTETIIDKSKSVKTVLMQLFEESGNTDVEGIDTTNACYGGTAALFNAVNWVESSSWDGRYALVVAGDIAVYATGSARPTGGAGAVAMLVGPNAPLAFDRGLRGTHMQHAYDFYKPDMVSEYPVVDGKLSIQCYLSALDRCYSVYRNKIQAQWQREGL--ERNFNLDEFGYMVFHSPYCKLVQKSLARLLLNDFLYHPSPNTE-SGPFSGLEAFRDVKIEDTYFDRDVEKAFMKASAEMFEQKTKASLLISNQNGNMYTPSVYGCLASVLAQHTPQQVAGQRIGVFSYGSGFAATLYSIKVTQDATPGSALDKLVSSLSDLKARLDSRRKVAPGVFADNMKLREDTHHLANYIPQGPVDELFPGTWYLTRVDEKHRRYY 467

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BLAST of 3-hydroxy-3-methylglutaryl coenzyme A synthase vs. Ensembl Cavefish
Match: hmgcs1 (hydroxymethylglutaryl-CoA synthase, cytoplasmic-like [Source:NCBI gene;Acc:103042817])

HSP 1 Score: 397.897 bits (1021), Expect = 4.597e-133
Identity = 215/455 (47.25%), Postives = 303/455 (66.59%), Query Frame = 1

Query:   10 DIGIKAVEIYFPNTCIDQKDLEESDNC-LGKYTVGLGQIKMGVCSDLEDINSIALTVTKQLLENNFIDPNDIGFLSVGTETLIDKSKSTKTVLMELFEKHGNTDIQGVDEKNACFGGTASLFAALDWLESSNCDGRLXXXXXXXXXXXXXXXXRCTGGAGAVAMLLGPNAPLIFDKGIRSHHMSHQWDFYKPKLDSEYPVYDGQLSIISYQKSIDKCFQLYKKK----CLNKGLINQSMILFRENYYFCFHSPYTKLVEKSFARLVFNDIKDNPDIVEQFNEQLEDIKPFLHLNIENTYGNRDFDLSFLKFSDTLIKDKLRPGVLMAQNNGNMYTASLYGSLISVLIQTPIEELVGSRIVLFSYGSGLASCMFSLMITENKMK---LSEIKDSLNKIVDNLKNRIILSYKEFEDFLARRSSINCKCNVKPSTELSYLRSGTFYLSEIDEKYRRKY 1350
            D+GI A+E+Y P+  +DQ +LEE D    GKYT+GLGQ +MG CSD EDINS+ LTV +QL+E N +  + +G L VGTET+IDKSKS KTVLM+LFE+ GNTD++G+D  NAC+GGTA+LF A++W+ESS+ DGR A+VVA DIA+YA  +AR TGGAGAVAML+GPNAPL FD+G+R  HM H +DFYKP + SEYPV DG+LSI  Y  ++D+C+ +Y+ K       +GL  +      E  Y  FHSPY KLV+KS ARL+ ND   +P    + +     ++ F  + IE+TY +RD + +F+K S  + + K +  +L++  NGNMYT S+YG L SVL Q   +++ G RI +FSYGSG A+ ++S+ +T++      L ++  SL+ +   L +R  ++   F D +  R   +   N  P   +  L  GT+YL+ +DEK+RR Y
Sbjct:   23 DVGIIAMEVYIPSQYVDQTELEEFDGVGAGKYTIGLGQAQMGFCSDREDINSLCLTVVQQLMERNCLSYDSVGRLEVGTETIIDKSKSVKTVLMQLFEESGNTDVEGIDTTNACYGGTAALFNAVNWVESSSWDGRYALVVAGDIAVYATGSARPTGGAGAVAMLVGPNAPLAFDRGLRGTHMQHAYDFYKPDMVSEYPVVDGKLSIQCYLSALDRCYSVYRNKIQAQWQREGL--ERNFNLDEFGYMVFHSPYCKLVQKSLARLLLNDFLYHPSPNTE-SGPFSGLEAFRDVKIEDTYFDRDVEKAFMKASAEMFEQKTKASLLISNQNGNMYTPSVYGCLASVLAQHTPQQVAGQRIGVFSYGSGFAATLYSIKVTQDATPGSALDKLVSSLSDLKARLDSRRKVAPGVFADNMKLREDTHHLANYIPQGPVDELFPGTWYLTRVDEKHRRYY 474

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BLAST of 3-hydroxy-3-methylglutaryl coenzyme A synthase vs. Ensembl Yeast
Match: ERG13 (3-hydroxy-3-methylglutaryl-CoA (HMG-CoA) synthase; catalyzes the formation of HMG-CoA from acetyl-CoA and acetoacetyl-CoA; involved in the second step in mevalonate biosynthesis [Source:SGD;Acc:S000004595])

HSP 1 Score: 341.658 bits (875), Expect = 1.862e-112
Identity = 190/455 (41.76%), Postives = 291/455 (63.96%), Query Frame = 1

Query:   10 DIGIKAVEIYFPNTCIDQKDLEESDNC-LGKYTVGLGQIKMGVCSDLEDINSIALTVTKQLLENNFIDPNDIGFLSVGTETLIDKSKSTKTVLMELFEKHGNTDIQGVDEKNACFGGTASLFAALDWLESSNCDGRLXXXXXXXXXXXXXXXXRCTGGAGAVAMLLGPNAPLIFDKGIRSHHMSHQWDFYKPKLDSEYPVYDGQLSIISYQKSIDKCFQLYKKKCLNKGLI-----NQSMILFRENYYFCFHSPYTKLVEKSFARLVFNDIKDNPDIVEQFNEQLEDIKPFLHLNIENTYGNRDFDLSFLKFSDTLIKDKLRPGVLMAQNNGNMYTASLYGSLISVLIQTPIEELVGSRIVLFSYGSGLASCMFSLMITENKMKLSEIKDSLNKIVDNLKNRIILSYKEFEDFLARRSSINCKCNVKPSTELSYLRSGTFYLSEIDEKYRRKYQI 1356
            ++GIK ++IY P  C++Q +LE+ D    GKYT+GLGQ  M   +D EDI S++LTV  +L+++  ID N IG L VGTETLIDKSKS K+VLM+LF +  NTD++G+D  NAC+GGT +LF +L+W+ES+  DGR AIVV  DIAIY + AAR TGGAG VAM +GP+AP++FD  +R+ +M H +DFYKP   SEYP  DG  S+  Y K++D+ ++ Y KK ++KGL+     + ++ + +   Y  FH P  KLV KS+ RL++ND + NP +  + + +L         + + +  +++ + +F+  +    K+++   +++  N GNMYTAS+Y +  S+L     ++L G R+ LFSYGSGLA+ ++S  I  +   + +  D  NK    L  RI  + K++E  +  R + + K N KP   + +L+SG +YL+ ID+K+RR Y +
Sbjct:   48 NVGIKGIQIYIPTQCVNQSELEKFDGVSQGKYTIGLGQTNMSFVNDREDIYSMSLTVLSKLIKSYNIDTNKIGRLEVGTETLIDKSKSVKSVLMQLFGE--NTDVEGIDTLNACYGGTNALFNSLNWIESNAWDGRDAIVVCGDIAIYDKGAARPTGGAGTVAMWIGPDAPIVFD-SVRASYMEHAYDFYKPDFTSEYPYVDGHFSLTCYVKALDQVYKSYSKKAISKGLVSDPAGSDALNVLKYFDYNVFHVPTCKLVTKSYGRLLYNDFRANPQLFPEVDAELAT------RDYDESLTDKNIEKTFVNVAKPFHKERVAQSLIVPTNTGNMYTASVYAAFASLLNYVGSDDLQGKRVGLFSYGSGLAASLYSCKIVGDVQHIIKELDITNK----LAKRITETPKDYEAAIELRENAHLKKNFKPQGSIEHLQSGVYYLTNIDDKFRRSYDV 489

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BLAST of 3-hydroxy-3-methylglutaryl coenzyme A synthase vs. Ensembl Nematostella
Match: EDO36099 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7SJQ1])

HSP 1 Score: 372.474 bits (955), Expect = 2.587e-124
Identity = 209/455 (45.93%), Postives = 291/455 (63.96%), Query Frame = 1

Query:   10 DIGIKAVEIYFPNTCIDQKDLEESDNCL-GKYTVGLGQIKMGVCSDLEDINSIALTVTKQLLENNFIDPNDIGFLSVGTETLIDKSKSTKTVLMELFEKHGNTDIQGVDEKNACFGGTASLFAALDWLESSNCDGRLXXXXXXXXXXXXXXXXRCTGGAGAVAMLLGPNAPLIFDKGIRSHHMSHQWDFYKPKLDSEYPVYDGQLSIISYQKSIDKCFQLYKKKCLNKGLINQSMILFRENYYFCFHSPYTKLVEKSFARLVFNDIKDNPDIVEQFNEQLEDIKPFLHLNIENTYGN----RDFDLSFLKFSDTLIKDKLRPGVLMAQNNGNMYTASLYGSLISVLIQTPIEELVGSRIVLFSYGSGLASCMFSLMI---TENKMKLSEIKDSLNKIVDNLKNRIILSYKEFEDFLARRSSINCKCNVKPSTELSYLRSGTFYLSEIDEKYRRKY 1350
            ++GI A+E+Y P T + Q+ LEE D    GKYT+GLGQ  MG CSD EDINS+ALTV + LLE   +DPN IG L VGTET+IDKSKS K+VLM+LFE  GNT+I+G+D  NAC+GGT +LF AL W+ESS  DGRLAIVVAADIA+YA   AR +GGAGAVAML+GP+APL+ ++G+R   M H +DFYKP + SEYPV DG+LSI  Y  ++D+C++ + +K     + N+  +   +  Y  FH+P+ K+V+KS AR+   D         + +EQ   + P+  + +  T+ +    ++ + + +K S  +   K RP   +AQ+ GNMYT SLYGSL+S+L   P  +L G RI +FSYGSGLAS MFS+ +   +     L+ +  SL+ +   L  R  +S  +F   L  R   +   +  P   +  L  GT+YL  +D+K+RRKY
Sbjct:   15 NVGILAMELYVPKTYVSQERLEEFDGVSKGKYTIGLGQRGMGFCSDREDINSLALTVVQNLLEKKHLDPNKIGRLEVGTETIIDKSKSVKSVLMQLFEDSGNTEIEGIDTTNACYGGTQALFNALSWIESSAWDGRLAIVVAADIAVYAAGNARSSGGAGAVAMLVGPHAPLVVERGLRGVFMQHAYDFYKPDMTSEYPVVDGRLSIKCYFNAVDQCYKAFTEKTAK--VENKDSVGLEDIDYVAFHTPFCKIVQKSLARMYLADFLKGYRQGTRKDEQ-SLLHPYRDIKLSETFQDENLAKEIEKASVKASQGVFDAKARPCTHVAQDVGNMYTPSLYGSLVSLLNSVPASQLAGKRIGMFSYGSGLASAMFSIRVSPKSSPSSPLTNLVGSLSDVPSRLACRSEVSPSDFVATLELREKTHHASSYVPKGSIHMLFPGTYYLESVDDKFRRKY 466

[Close]

BLAST of 3-hydroxy-3-methylglutaryl coenzyme A synthase vs. Ensembl Medaka
Match: hmgcs1 (3-hydroxy-3-methylglutaryl-CoA synthase 1 [Source:NCBI gene;Acc:101172510])

HSP 1 Score: 392.889 bits (1008), Expect = 3.142e-131
Identity = 216/458 (47.16%), Postives = 304/458 (66.38%), Query Frame = 1

Query:   10 DIGIKAVEIYFPNTCIDQKDLEESDN-CLGKYTVGLGQIKMGVCSDLEDINSIALTVTKQLLENNFIDPNDIGFLSVGTETLIDKSKSTKTVLMELFEKHGNTDIQGVDEKNACFGGTASLFAALDWLESSNCDGRLXXXXXXXXXXXXXXXXRCTGGAGAVAMLLGPNAPLIFDKGIRSHHMSHQWDFYKPKLDSEYPVYDGQLSIISYQKSIDKCFQLYKKKCLNKGLINQSMILFR-ENYYF-CFHSPYTKLVEKSFARLVFNDIKDNPDIVEQFN-----EQLEDIKPFLHLNIENTYGNRDFDLSFLKFSDTLIKDKLRPGVLMAQNNGNMYTASLYGSLISVLIQTPIEELVGSRIVLFSYGSGLASCMFSLMITENKMK---LSEIKDSLNKIVDNLKNRIILSYKEFEDFLARRSSINCKCNVKPSTELSYLRSGTFYLSEIDEKYRRKY 1350
            D+GI A+E+YFP+  +DQ +LE+ D    GKYTVGLGQ +MG CSD EDINS+ LTV ++L+E N +  + IG L VGTET+IDKSKS KTV+M+LFE  GNTD++G+D  NAC+GGTA+LF A++W+ESS+ DGR A+VVA DIA+YA  +AR TGGAGAVAML+GPNAPL F++G+R  HM H +DFYKP L SEYPV DG+LSI  Y  ++D+C+ +Y+ K   +     S   F  E++ F  FHSPY KLV+KS ARL+ ND  ++P+   +       +   D+KP      E TY +RD + +F+K S  L + K +  +L++  NGNMYT S+YG L SV+ +    +L G RI +FSYGSG A+ ++SL +T++      L ++  SL+ +   L +R  ++   F D +  R   +   +  P   +  L  GT+YL+ +DEK+RR+Y
Sbjct:   16 DVGIIALELYFPSHFVDQAELEQYDGVAAGKYTVGLGQARMGFCSDREDINSLCLTVVQRLMERNGLSYDSIGRLEVGTETIIDKSKSVKTVIMQLFEDSGNTDVEGIDTTNACYGGTAALFNAVNWVESSSWDGRFALVVAGDIAVYATGSARPTGGAGAVAMLVGPNAPLAFERGLRGTHMQHAYDFYKPDLMSEYPVVDGKLSIECYLSALDRCYSVYRNKIHTQWQREGSDQRFSLEDFGFLVFHSPYCKLVQKSVARLMLNDFLNHPNPNTETGPFTGLDAFRDVKP------EETYFDRDVEKAFMKASADLFERKTKTSLLISNQNGNMYTPSVYGCLASVIAEHSPSQLAGQRIGVFSYGSGFAASLYSLKVTQDHTPGSALDKLVSSLSDLGVRLDSRKKVAPAVFSDSMKLREDTHHLASYVPRGSVDDLFPGTWYLTRVDEKHRREY 467

[Close]

BLAST of 3-hydroxy-3-methylglutaryl coenzyme A synthase vs. Ensembl Medaka
Match: hmgcs1 (3-hydroxy-3-methylglutaryl-CoA synthase 1 [Source:NCBI gene;Acc:101172510])

HSP 1 Score: 332.413 bits (851), Expect = 2.902e-108
Identity = 186/458 (40.61%), Postives = 268/458 (58.52%), Query Frame = 1

Query:   10 DIGIKAVEIYFPNTCIDQKDLEESDN-CLGKYTVGLGQIKMGVCSDLEDINSIALTVTKQLLENNFIDPNDIGFLSVGTETLIDKSKSTKTVLMELFEKHGNTDIQGVDEKNACFGGTASLFAALDWLESSNCDGRLXXXXXXXXXXXXXXXXRCTGGAGAVAMLLGPNAPLIFDKGIRSHHMSHQWDFYKPKLDSEYPVYDGQLSIISYQKSIDKCFQLYKKKCLNKGLINQSMILFR-ENYYF-CFHSPYTKLVEKSFARLVFNDIKDNPDIVEQFN-----EQLEDIKPFLHLNIENTYGNRDFDLSFLKFSDTLIKDKLRPGVLMAQNNGNMYTASLYGSLISVLIQTPIEELVGSRIVLFSYGSGLASCMFSLMITENKMK---LSEIKDSLNKIVDNLKNRIILSYKEFEDFLARRSSINCKCNVKPSTELSYLRSGTFYLSEIDEKYRRKY 1350
            D+GI A+E+YFP+  +DQ +LE+ D    GKYTVGLGQ +MG CSD EDINS+ LTV ++L+E N +  + IG L VGTET+IDKSKS KTV+M+LFE  GNTD++G+D  NAC+GGTA+LF A++W+ESS+ DG                                          +R  HM H +DFYKP L SEYPV DG+LSI  Y  ++D+C+ +Y+ K   +     S   F  E++ F  FHSPY KLV+KS ARL+ ND  ++P+   +       +   D+KP      E TY +RD + +F+K S  L + K +  +L++  NGNMYT S+YG L SV+ +    +L G RI +FSYGSG A+ ++SL +T++      L ++  SL+ +   L +R  ++   F D +  R   +   +  P   +  L  GT+YL+ +DEK+RR+Y
Sbjct:   16 DVGIIALELYFPSHFVDQAELEQYDGVAAGKYTVGLGQARMGFCSDREDINSLCLTVVQRLMERNGLSYDSIGRLEVGTETIIDKSKSVKTVIMQLFEDSGNTDVEGIDTTNACYGGTAALFNAVNWVESSSWDG------------------------------------------LRGTHMQHAYDFYKPDLMSEYPVVDGKLSIECYLSALDRCYSVYRNKIHTQWQREGSDQRFSLEDFGFLVFHSPYCKLVQKSVARLMLNDFLNHPNPNTETGPFTGLDAFRDVKP------EETYFDRDVEKAFMKASADLFERKTKTSLLISNQNGNMYTPSVYGCLASVIAEHSPSQLAGQRIGVFSYGSGFAASLYSLKVTQDHTPGSALDKLVSSLSDLGVRLDSRKKVAPAVFSDSMKLREDTHHLASYVPRGSVDDLFPGTWYLTRVDEKHRREY 425

[Close]

BLAST of 3-hydroxy-3-methylglutaryl coenzyme A synthase vs. Planmine SMEST
Match: SMESG000010026.1 (SMESG000010026.1)

HSP 1 Score: 812.372 bits (2097), Expect = 0.000e+0
Identity = 412/414 (99.52%), Postives = 412/414 (99.52%), Query Frame = 1

Query:    1 MTIDIGIKAVEIYFPNTCIDQKDLEESDNCLGKYTVGLGQIKMGVCSDLEDINSIALTVTKQLLENNFIDPNDIGFLSVGTETLIDKSKSTKTVLMELFEKHGNTDIQGVDEKNACFGGTASLFAALDWLESSNCDGRLXXXXXXXXXXXXXXXXRCTGGAGAVAMLLGPNAPLIFDKGIRSHHMSHQWDFYKPKLDSEYPVYDGQLSIISYQKSIDKCFQLYKKKCLNKGLINQSMILFRENYYFCFHSPYTKLVEKSFARLVFNDIKDNPDIVEQFNEQLEDIKPFLHLNIENTYGNRDFDLSFLKFSDTLIKDKLRPGVLMAQNNGNMYTASLYGSLISVLIQTPIEELVGSRIVLFSYGSGLASCMFSLMITENKMKLSEIKDSLNKIVDNLKNRIILSYKEFEDFLARR 1242
            MTIDIGIKAVEIYFPNTCIDQKDLEESDNCLGKYTVGLGQIKMGVCSDLEDINSIALTVTKQLLENNFIDPNDIGFLSVGTETLIDKSKSTKTVLMELFEKHGNTDIQGVDEKNACFGGTASLFAALDWLESSNCDGRLAIVVAADIAIYAEKAARCTGGAGAVAMLLGPNAPLIFDKGIRSHHMSHQWDFYKPKLDSEYPVYDGQLSIISYQKSIDKCFQLYKKKCLNKGLINQSMILFRENYYFCFHSPYTKLVEKSFARLVFNDIKDNPDIVEQFNEQLEDIKPFLHLNIENTYGNRDFDLSFLKFSDTLIKDKLRPGVLMAQNNGNMYTASLYGSLISVLIQTPIEELVGSRIVLFSYGSGLASCMFSLMITENKMKLSEIKDSLNKIVDNLKNRIILSYKEFEDFLA  
Sbjct:    1 MTIDIGIKAVEIYFPNTCIDQKDLEESDNCLGKYTVGLGQIKMGVCSDLEDINSIALTVTKQLLENNFIDPNDIGFLSVGTETLIDKSKSTKTVLMELFEKHGNTDIQGVDEKNACFGGTASLFAALDWLESSNCDGRLAIVVAADIAIYAEKAARCTGGAGAVAMLLGPNAPLIFDKGIRSHHMSHQWDFYKPKLDSEYPVYDGQLSIISYQKSIDKCFQLYKKKCLNKGLINQSMILFRENYYFCFHSPYTKLVEKSFARLVFNDIKDNPDIVEQFNEQLEDIKPFLHLNIENTYGNRDFDLSFLKFSDTLIKDKLRPGVLMAQNNGNMYTASLYGSLISVLIQTPIEELVGSRIVLFSYGSGLASCMFSLMITENKMKLSEIKDSLNKIVDNLKNRIILSYKEFEDFLAEE 414

The following BLAST results are available for this feature:

BLAST of 3-hydroxy-3-methylglutaryl coenzyme A synthase vs. Ensembl Human
BLAST of 3-hydroxy-3-methylglutaryl coenzyme A synthase vs. Ensembl Celegans
BLAST of 3-hydroxy-3-methylglutaryl coenzyme A synthase vs. Ensembl Fly
BLAST of 3-hydroxy-3-methylglutaryl coenzyme A synthase vs. Ensembl Zebrafish
BLAST of 3-hydroxy-3-methylglutaryl coenzyme A synthase vs. Ensembl Xenopus
BLAST of 3-hydroxy-3-methylglutaryl coenzyme A synthase vs. Ensembl Mouse
BLAST of 3-hydroxy-3-methylglutaryl coenzyme A synthase vs. UniProt/SwissProt
BLAST of 3-hydroxy-3-methylglutaryl coenzyme A synthase vs. TrEMBL
BLAST of 3-hydroxy-3-methylglutaryl coenzyme A synthase vs. Ensembl Cavefish
BLAST of 3-hydroxy-3-methylglutaryl coenzyme A synthase vs. Ensembl Sea Lamprey
BLAST of 3-hydroxy-3-methylglutaryl coenzyme A synthase vs. Ensembl Yeast
BLAST of 3-hydroxy-3-methylglutaryl coenzyme A synthase vs. Ensembl Nematostella
BLAST of 3-hydroxy-3-methylglutaryl coenzyme A synthase vs. Ensembl Medaka
BLAST of 3-hydroxy-3-methylglutaryl coenzyme A synthase vs. Planmine SMEST

BLAST of 3-hydroxy-3-methylglutaryl coenzyme A synthase vs. Ensembl Human
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Human e!99)
Total hits: 5


Match Name	E-value	Identity	Description
HMGCS2	1.510e-130	47.14	3-hydroxy-3-methylglutaryl-CoA synthase 2 [Source:...	[more]
HMGCS1	1.150e-128	46.80	3-hydroxy-3-methylglutaryl-CoA synthase 1 [Source:...	[more]
HMGCS1	1.150e-128	46.80	3-hydroxy-3-methylglutaryl-CoA synthase 1 [Source:...	[more]
HMGCS2	3.539e-110	41.41	3-hydroxy-3-methylglutaryl-CoA synthase 2 [Source:...	[more]
HMGCS1	2.437e-20	55.00	3-hydroxy-3-methylglutaryl-CoA synthase 1 [Source:...	[more]

BLAST of 3-hydroxy-3-methylglutaryl coenzyme A synthase vs. Ensembl Celegans
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99)
Total hits: 1


Match Name	E-value	Identity	Description
hmgs-1	2.073e-83	39.34	Hydroxymethylglutaryl-CoA synthase [Source:UniPro...	[more]

BLAST of 3-hydroxy-3-methylglutaryl coenzyme A synthase vs. Ensembl Fly
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99)
Total hits: 5


Match Name	E-value	Identity	Description
Hmgs	3.551e-135	46.96	gene:FBgn0010611 transcript:FBtr0340059	[more]
Hmgs	3.551e-135	46.96	gene:FBgn0010611 transcript:FBtr0087146	[more]
Hmgs	3.551e-135	46.96	gene:FBgn0010611 transcript:FBtr0087147	[more]
Hmgs	3.551e-135	46.96	gene:FBgn0010611 transcript:FBtr0087148	[more]
Hmgs	3.551e-135	46.96	gene:FBgn0010611 transcript:FBtr0087145	[more]

BLAST of 3-hydroxy-3-methylglutaryl coenzyme A synthase vs. Ensembl Zebrafish
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99)
Total hits: 4


Match Name	E-value	Identity	Description
hmgcs1	1.339e-133	47.68	3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble...	[more]
hmgcs1	1.339e-133	47.68	3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble...	[more]
hmgcs1	5.153e-96	57.30	3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble...	[more]
hmgcs1	2.765e-60	63.69	3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble...	[more]

BLAST of 3-hydroxy-3-methylglutaryl coenzyme A synthase vs. Ensembl Xenopus
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99)
Total hits: 3


Match Name	E-value	Identity	Description
hmgcs1	1.449e-133	49.45	3-hydroxy-3-methylglutaryl-CoA synthase 1 [Source:...	[more]
hmgcs1	2.217e-133	49.45	3-hydroxy-3-methylglutaryl-CoA synthase 1 [Source:...	[more]
hmgcs1	3.430e-133	49.45	3-hydroxy-3-methylglutaryl-CoA synthase 1 [Source:...	[more]

BLAST of 3-hydroxy-3-methylglutaryl coenzyme A synthase vs. Ensembl Mouse
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99)
Total hits: 4


Match Name	E-value	Identity	Description
Hmgcs2	1.445e-132	47.24	3-hydroxy-3-methylglutaryl-Coenzyme A synthase 2 [...	[more]
Hmgcs2	1.445e-132	47.24	3-hydroxy-3-methylglutaryl-Coenzyme A synthase 2 [...	[more]
Hmgcs1	3.255e-129	47.02	3-hydroxy-3-methylglutaryl-Coenzyme A synthase 1 [...	[more]
Hmgcs1	3.255e-129	47.02	3-hydroxy-3-methylglutaryl-Coenzyme A synthase 1 [...	[more]

BLAST of 3-hydroxy-3-methylglutaryl coenzyme A synthase vs. UniProt/SwissProt
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt)
Total hits: 5


Match Name	E-value	Identity	Description
sp\|P54869\|HMCS2_MOUSE	1.011e-131	47.24	Hydroxymethylglutaryl-CoA synthase, mitochondrial ...	[more]
sp\|P22791\|HMCS2_RAT	5.407e-131	46.80	Hydroxymethylglutaryl-CoA synthase, mitochondrial ...	[more]
sp\|P54868\|HMCS2_HUMAN	7.250e-130	47.14	Hydroxymethylglutaryl-CoA synthase, mitochondrial ...	[more]
sp\|P23228\|HMCS1_CHICK	1.507e-129	47.68	Hydroxymethylglutaryl-CoA synthase, cytoplasmic OS...	[more]
sp\|P54961\|HMCS1_BLAGE	1.089e-128	47.59	Hydroxymethylglutaryl-CoA synthase 1 OS=Blattella ...	[more]

BLAST of 3-hydroxy-3-methylglutaryl coenzyme A synthase vs. TrEMBL
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL)
Total hits: 5


Match Name	E-value	Identity	Description
K1PE75	2.040e-142	49.78	3-hydroxy-3-methylglutaryl coenzyme A synthase OS=...	[more]
A0A0B7AGV3	8.795e-137	49.03	3-hydroxy-3-methylglutaryl coenzyme A synthase OS=...	[more]
A0A0J7N5E3	4.033e-136	48.79	3-hydroxy-3-methylglutaryl coenzyme A synthase OS=...	[more]
A0A3S3NZT7	4.285e-136	48.48	3-hydroxy-3-methylglutaryl coenzyme A synthase (Fr...	[more]
A0A195EGG4	4.637e-136	49.45	3-hydroxy-3-methylglutaryl coenzyme A synthase OS=...	[more]

BLAST of 3-hydroxy-3-methylglutaryl coenzyme A synthase vs. Ensembl Cavefish
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99)
Total hits: 2


Match Name	E-value	Identity	Description
hmgcs1	3.004e-133	47.25	hydroxymethylglutaryl-CoA synthase, cytoplasmic-li...	[more]
hmgcs1	4.597e-133	47.25	hydroxymethylglutaryl-CoA synthase, cytoplasmic-li...	[more]

BLAST of 3-hydroxy-3-methylglutaryl coenzyme A synthase vs. Ensembl Sea Lamprey
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99)
Total hits: 0


Match Name	E-value	Identity	Description

BLAST of 3-hydroxy-3-methylglutaryl coenzyme A synthase vs. Ensembl Yeast
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46)
Total hits: 1


Match Name	E-value	Identity	Description
ERG13	1.862e-112	41.76	3-hydroxy-3-methylglutaryl-CoA (HMG-CoA) synthase;...	[more]

BLAST of 3-hydroxy-3-methylglutaryl coenzyme A synthase vs. Ensembl Nematostella
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46)
Total hits: 1


Match Name	E-value	Identity	Description
EDO36099	2.587e-124	45.93	Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7...	[more]

BLAST of 3-hydroxy-3-methylglutaryl coenzyme A synthase vs. Ensembl Medaka
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99)
Total hits: 2


Match Name	E-value	Identity	Description
hmgcs1	3.142e-131	47.16	3-hydroxy-3-methylglutaryl-CoA synthase 1 [Source:...	[more]
hmgcs1	2.902e-108	40.61	3-hydroxy-3-methylglutaryl-CoA synthase 1 [Source:...	[more]

BLAST of 3-hydroxy-3-methylglutaryl coenzyme A synthase vs. Planmine SMEST
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST)
Total hits: 1


Match Name	E-value	Identity	Description
SMESG000010026.1	0.000e+0	99.52	SMESG000010026.1	[more]

Analyses

This transcript is derived from or has results from the following analyses


Analysis Name	Date Performed
Embryonic Stages	2016-07-25
Schmidtea mediterranea smed_20140614 BLASTX Human e!99	2016-08-08
Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99	2016-08-08
Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL	2020-05-01
Schmidtea mediterranea Sexual smed_20140614 transcriptome	2016-07-25
Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST	2020-05-08

Sequences

The following sequences are available for this feature:

transcript sequence
protein sequence

transcript sequence

>SMED30011849 ID=SMED30011849|Name=3-hydroxy-3-methylglutaryl coenzyme A synthase|organism=Schmidtea mediterranea sexual|type=transcript|length=1632bp
ATGACTATCGACATTGGAATAAAAGCTGTTGAGATTTATTTTCCAAATAC
ATGTATAGATCAAAAAGACTTAGAAGAATCTGACAACTGTTTAGGAAAAT
ACACTGTTGGACTGGGTCAAATAAAAATGGGTGTATGTAGTGATTTAGAA
GATATTAATTCTATTGCTTTAACTGTTACTAAGCAGTTATTAGAAAACAA
TTTTATTGATCCTAATGACATTGGTTTCTTATCAGTAGGTACTGAAACTT
TAATAGATAAATCCAAATCTACTAAAACTGTTCTTATGGAACTTTTTGAA
AAACATGGAAATACAGATATTCAAGGAGTGGATGAAAAAAATGCTTGTTT
CGGTGGAACGGCTTCTTTATTTGCAGCACTCGATTGGTTGGAGAGTAGTA
ATTGTGATGGAAGACTGGCTATAGTTGTAGCGGCAGATATTGCTATTTAT
GCTGAAAAAGCAGCTCGTTGTACTGGTGGAGCTGGTGCAGTCGCAATGCT
TCTTGGTCCTAATGCCCCACTGATCTTTGATAAAGGAATAAGATCTCATC
ATATGTCCCATCAATGGGATTTTTACAAACCAAAACTTGATTCAGAATAT
CCTGTTTATGATGGTCAATTGAGCATAATTTCTTATCAAAAGTCCATTGA
TAAATGTTTTCAACTCTATAAGAAGAAATGTCTTAATAAAGGACTTATCA
ATCAGTCAATGATTTTATTCCGAGAAAATTATTATTTTTGTTTTCATTCA
CCTTACACAAAATTAGTTGAGAAGTCATTTGCTCGTCTTGTGTTCAATGA
TATTAAAGATAATCCAGATATCGTTGAACAATTTAATGAGCAATTGGAAG
ACATTAAACCATTTTTACATCTAAATATTGAAAACACCTATGGAAATAGA
GATTTTGATCTTAGTTTTCTCAAATTCAGTGACACTTTGATAAAAGATAA
ACTTCGTCCCGGAGTTTTAATGGCCCAGAATAATGGAAATATGTATACTG
CATCACTGTATGGGAGTCTTATTTCCGTTTTGATTCAAACTCCAATTGAG
GAACTTGTAGGCTCAAGGATAGTTTTATTTTCATATGGTTCTGGACTTGC
ATCTTGCATGTTCTCATTAATGATAACTGAAAACAAGATGAAATTATCCG
AAATAAAAGATAGTTTAAATAAAATTGTCGACAACCTTAAGAATCGGATT
ATTTTAAGCTATAAAGAATTTGAGGATTTCCTGGCAAGAAGAAGTTCTAT
CAATTGCAAATGTAATGTCAAACCTTCAACAGAACTTTCCTACTTAAGGT
CCGGTACATTTTATCTTAGTGAGATTGATGAAAAATATCGACGAAAATAT
CAAATTTACAATAGTGAGATTACAAATGGATATTCACATTATTAAACTAT
TTATTCGTTTGTTATTAATTTATTTTTACTTATTTGATCAAATAAAAATA
TGAATATTGTGCTTTCTTGATTTATTGTGATAATTAAAAATTGTGGTTAA
AAATTCATTATGGCAAAGTTTAGCTTATGATAGGGTGGGTATGAGGAAAA
TCTATAATTTTAATGACCCTGTAATATTATTTCTAATTAGAACCGACATG
CTTGAGTGCATTTATTTTAAATTGAACCAGAC

protein sequence of SMED30011849-orf-1

>SMED30011849-orf-1 ID=SMED30011849-orf-1|Name=SMED30011849-orf-1|organism=Schmidtea mediterranea sexual|type=polypeptide|length=465bp
MTIDIGIKAVEIYFPNTCIDQKDLEESDNCLGKYTVGLGQIKMGVCSDLE
DINSIALTVTKQLLENNFIDPNDIGFLSVGTETLIDKSKSTKTVLMELFE
KHGNTDIQGVDEKNACFGGTASLFAALDWLESSNCDGRLAIVVAADIAIY
AEKAARCTGGAGAVAMLLGPNAPLIFDKGIRSHHMSHQWDFYKPKLDSEY
PVYDGQLSIISYQKSIDKCFQLYKKKCLNKGLINQSMILFRENYYFCFHS
PYTKLVEKSFARLVFNDIKDNPDIVEQFNEQLEDIKPFLHLNIENTYGNR
DFDLSFLKFSDTLIKDKLRPGVLMAQNNGNMYTASLYGSLISVLIQTPIE
ELVGSRIVLFSYGSGLASCMFSLMITENKMKLSEIKDSLNKIVDNLKNRI
ILSYKEFEDFLARRSSINCKCNVKPSTELSYLRSGTFYLSEIDEKYRRKY
QIYNSEITNGYSHY*

Annotated Terms

The following terms have been associated with this transcript:

Vocabulary: **biological process**
Term	Definition
GO:0006629	lipid metabolic process
GO:0006694	steroid biosynthetic process
GO:0008202	steroid metabolic process
GO:0016126	sterol biosynthetic process
GO:0008152	metabolic process
GO:0008299	isoprenoid biosynthetic process

Vocabulary: **molecular function**
Term	Definition
GO:0016740	transferase activity
GO:0003824	catalytic activity
GO:0004421	hydroxymethylglutaryl-CoA synthase activity

Vocabulary: **Planarian Anatomy**
Term	Definition
PLANA:0000034	epidermis
PLANA:0000054	dorsal region of the epidermis
PLANA:0000106	ciliated epithelial cell
PLANA:0002032	epidermal cell

Vocabulary: **INTERPRO**
Term	Definition
IPR016039	Thiolase-like
IPR013746	HMG_CoA_synt_C_dom
IPR013528	HMG_CoA_synth_N

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3-hydroxy-3-methylglutaryl coenzyme A synthase

Zeng et. al., 2018

▻ Overview

▻ Neoblast Population

▻ Sub-lethal Irradiated Surviving X1 and X2 Cell Population

Overview

Single cell RNA-seq of pluripotent neoblasts and its early progenies

Explore this single cell expression dataset with our NB Cluster Shiny App

Neoblast Population

Sub-lethal Irradiated Surviving X1 and X2 Cell Population

Davies et. al., 2017

PAGE et. al., 2020

has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGE

PAGE Curations: 5

Owlery

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