RING-type domain-containing protein

Overview


Name	RING-type domain-containing protein
Smed ID	SMED30011825
Length (bp)	1501

Neoblast Clusters

▻ Sub-lethal Irradiated Surviving X1 and X2 Cell Population

Overview

Single cell RNA-seq of pluripotent neoblasts and its early progenies

We isolated X1 neoblasts cells enriched in high piwi-1 expression (Neoblast Population), and profiled ∼7,614 individual cells via scRNA-seq. Unsupervised analyses uncovered 12 distinct classes from 7,088 high-quality cells. We designated these classes Nb1 to Nb12 and ordered them based on high (Nb1) to low (Nb12) piwi-1 expression levels. We further defined groups of genes that best classified the cells parsed into 12 distinct cell clusters to generate a scaled expression heat map of discriminative gene sets for each cluster. Expression of each cluster’s gene signatures was validated using multiplex fluorescence in situ hybridization (FISH) co-stained with piwi-1 and largely confirmed the cell clusters revealed by scRNA-seq.

We also tested sub-lethal irradiation exposure. To profile rare pluripotent stem cells (PSCs) and avoid interference from immediate progenitor cells, we determined a time point after sub-lethal irradiation (7 DPI) with minimal piwi-1+ cells, followed by isolation and single-cell RNA-seq of 1,200 individual cells derived from X1 (Piwi-1 high) and X2 (Piwi-1 low) cell populations (Sub-lethal Irradiated Surviving X1 and X2 Cell Population)

Explore this single cell expression dataset with our NB Cluster Shiny App

Neoblast Population

t-SNE plot shows two-dimensional representation of global gene expression relationships among all neoblasts (n = 7,088 after filter). Cluster identity was assigned based on the top 10 marker genes of each cluster (Table S2), followed by inspection of RNA in situ hybridization patterns. Neoblast groups, Nb.

Expression of RING-type domain-containing protein (SMED30011825) t-SNE clustered cells

Violin plots show distribution of expression levels for RING-type domain-containing protein (SMED30011825) in cells (dots) of each of the 12 neoblast clusters.

Sub-lethal Irradiated Surviving X1 and X2 Cell Population

t-SNE plot of surviving X1 and X2 cells (n = 1,039 after QC filter) after sub-lethal irradiation. Colors indicate unbiased cell classification via graph-based clustering. SL, sub-lethal irradiated cell groups.

Expression of RING-type domain-containing protein (SMED30011825) in the t-SNE clustered sub-lethally irradiated X1 and X2 cells.

Violin plots show distribution of expression levels for RING-type domain-containing protein (SMED30011825) in cells (dots) of each of the 10 clusters of sub-leathally irradiated X1 and X2 cells.

Embryonic Expression

Davies et. al., 2017

Hover the mouse over a column in the graph to view average RPKM values per sample.
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Embryonic Stages: Y: yolk. S2-S8: Stages 2-8. C4: asexual adult. SX: virgin, sexually mature adult.
For further information about sample preparation and analysis for the single animal RNA-Seq experiment, please refer to the Materials and Methods

Anatomical Expression

PAGE et. al., 2020

SMED30011825

has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGE

PAGE Curations: 2

Expressed In	Reference Transcript	Gene Models	Published Transcript	Transcriptome	Publication	Specimen	Lifecycle	Evidence
nervous system	SMED30011825	SMESG000069649.1	dd_Smed_v4_12211_0_1	dd_Smed_v4	PMID:29674431 Fincher et al., 2018
head region	SMED30011825	SMESG000069649.1	dd_Smed_v6_12211_0_1	dd_Smed_v6	PMID:28171748 Stückemann et al., 2017

Note: Hover over icons to view figure legend

Homology

[Close]

BLAST of RING-type domain-containing protein vs. Ensembl Human
Match: TRIM3 (tripartite motif containing 3 [Source:HGNC Symbol;Acc:HGNC:10064])

HSP 1 Score: 48.9062 bits (115), Expect = 7.076e-7
Identity = 28/86 (32.56%), Postives = 43/86 (50.00%), Query Frame = 3

Query:  255 EDLTKSEIIDKLGEILECSIHHGIMTNPKMLSCQHTFCYKCIKDYFKIIQPLLICPICRREENV--DGVEKLPPSYIHNKLMEILK 506
            ED    E+     + L CSI       PK+L C HTFC +C+++Y       L CP+CR+   +   GV  L  ++  + LME ++
Sbjct:    5 EDSPGPEVQPMDKQFLVCSICLDRYQCPKVLPCLHTFCERCLQNYIPAQSLTLSCPVCRQTSILPEQGVSALQNNFFISSLMEAMQ 90

[Close]

BLAST of RING-type domain-containing protein vs. Ensembl Human
Match: TRIM2 (tripartite motif containing 2 [Source:HGNC Symbol;Acc:HGNC:15974])

HSP 1 Score: 48.521 bits (114), Expect = 2.514e-6
Identity = 29/78 (37.18%), Postives = 43/78 (55.13%), Query Frame = 3

Query:  279 IDKLGEILECSIHHGIMTNPKMLSCQHTFCYKCIKDYFKIIQPLLICPICRREENVD--GVEKLPPSYIHNKLMEILK 506
            IDK  + L CSI      NPK+L C HTFC +C+++Y       L CP+CR+   +   GV  L  ++    LM++L+
Sbjct:   16 IDK--QFLICSICLERYKNPKVLPCLHTFCERCLQNYIPAHSLTLSCPVCRQTSILPEKGVAALQNNFFITNLMDVLQ 91

[Close]

Query:  279 IDKLGEILECSIHHGIMTNPKMLSCQHTFCYKCIKDYFKIIQPLLICPICRREENVD--GVEKLPPSYIHNKLMEILK 506
            IDK  + L CSI      NPK+L C HTFC +C+++Y       L CP+CR+   +   GV  L  ++    LM++L+
Sbjct:   16 IDK--QFLICSICLERYKNPKVLPCLHTFCERCLQNYIPAHSLTLSCPVCRQTSILPEKGVAALQNNFFITNLMDVLQ 91

[Close]

BLAST of RING-type domain-containing protein vs. Ensembl Human
Match: TRIM2 (tripartite motif containing 2 [Source:HGNC Symbol;Acc:HGNC:15974])

HSP 1 Score: 48.1358 bits (113), Expect = 3.261e-6
Identity = 29/78 (37.18%), Postives = 43/78 (55.13%), Query Frame = 3

Query:  279 IDKLGEILECSIHHGIMTNPKMLSCQHTFCYKCIKDYFKIIQPLLICPICRREENVD--GVEKLPPSYIHNKLMEILK 506
            IDK  + L CSI      NPK+L C HTFC +C+++Y       L CP+CR+   +   GV  L  ++    LM++L+
Sbjct:   16 IDK--QFLICSICLERYKNPKVLPCLHTFCERCLQNYIPAHSLTLSCPVCRQTSILPEKGVAALQNNFFITNLMDVLQ 91

[Close]

BLAST of RING-type domain-containing protein vs. Ensembl Human
Match: TRIM2 (tripartite motif containing 2 [Source:HGNC Symbol;Acc:HGNC:15974])

HSP 1 Score: 50.8322 bits (120), Expect = 5.529e-6
Identity = 29/78 (37.18%), Postives = 43/78 (55.13%), Query Frame = 3

Query:  279 IDKLGEILECSIHHGIMTNPKMLSCQHTFCYKCIKDYFKIIQPLLICPICRREENV--DGVEKLPPSYIHNKLMEILK 506
            IDK  + L CSI      NPK+L C HTFC +C+++Y       L CP+CR+   +   GV  L  ++    LM++L+
Sbjct:   16 IDK--QFLICSICLERYKNPKVLPCLHTFCERCLQNYIPAHSLTLSCPVCRQTSILPEKGVAALQNNFFITNLMDVLQ 91

[Close]

BLAST of RING-type domain-containing protein vs. Ensembl Celegans
Match: nhl-1 (RING finger protein nhl-1 [Source:UniProtKB/Swiss-Prot;Acc:Q03601])

HSP 1 Score: 60.8474 bits (146), Expect = 1.827e-9
Identity = 29/76 (38.16%), Postives = 42/76 (55.26%), Query Frame = 3

Query:  279 IDKLGEILECSIHHGIMTNPKMLSCQHTFCYKCIKDYFKIIQPLLICPICRREENV--DGVEKLPPSYIHNKLMEI 500
            ++K+ ++L C I       PK+L CQHTFCY C++     +   L CP CR E N+  DGV+   P+Y     +EI
Sbjct:   34 LEKIEQLLTCPICLDRYKQPKLLPCQHTFCYPCLESCADTLHRNLKCPECRAEHNIPYDGVKAFQPNYTLTGFLEI 109

[Close]

BLAST of RING-type domain-containing protein vs. Ensembl Celegans
Match: nhl-1 (RING finger protein nhl-1 [Source:UniProtKB/Swiss-Prot;Acc:Q03601])

HSP 1 Score: 60.4622 bits (145), Expect = 1.874e-9
Identity = 29/76 (38.16%), Postives = 42/76 (55.26%), Query Frame = 3

Query:  279 IDKLGEILECSIHHGIMTNPKMLSCQHTFCYKCIKDYFKIIQPLLICPICRREENV--DGVEKLPPSYIHNKLMEI 500
            ++K+ ++L C I       PK+L CQHTFCY C++     +   L CP CR E N+  DGV+   P+Y     +EI
Sbjct:   34 LEKIEQLLTCPICLDRYKQPKLLPCQHTFCYPCLESCADTLHRNLKCPECRAEHNIPYDGVKAFQPNYTLTGFLEI 109

[Close]

BLAST of RING-type domain-containing protein vs. Ensembl Zebrafish
Match: trim2a (tripartite motif containing 2a [Source:ZFIN;Acc:ZDB-GENE-050327-99])

HSP 1 Score: 53.9138 bits (128), Expect = 3.500e-7
Identity = 31/78 (39.74%), Postives = 43/78 (55.13%), Query Frame = 3

Query:  279 IDKLGEILECSIHHGIMTNPKMLSCQHTFCYKCIKDYFKIIQPLLICPICRREENV--DGVEKLPPSYIHNKLMEILK 506
            IDK  + L CSI      NPK+L C HTFC +C+++Y       L CP+CR+   +   GV  L  ++    LME+LK
Sbjct:   16 IDK--QFLICSICLDRYNNPKVLPCLHTFCERCLQNYIPSHSLTLSCPVCRQTSILPEKGVAALQSNFFITNLMEVLK 91

[Close]

BLAST of RING-type domain-containing protein vs. Ensembl Zebrafish
Match: trim59 (tripartite motif containing 59 [Source:ZFIN;Acc:ZDB-GENE-060724-2])

HSP 1 Score: 51.2174 bits (121), Expect = 1.912e-6
Identity = 28/75 (37.33%), Postives = 42/75 (56.00%), Query Frame = 3

Query:  276 IIDKLGEILECSIHHGIMTNPKMLSCQHTFCYKCIKDY------FKIIQPL---LICPICRR--EENVDGVEKLP 467
            ++D L E L CS+ + + T+P++L C HTFC  C++        F I +PL   L CP CR   E   +G++ LP
Sbjct:   19 VMDSLEEDLTCSVCYALFTDPRVLPCSHTFCKSCLESVLQVSVNFSIWRPLRLPLKCPNCRSVVELPTNGLDALP 93

[Close]

BLAST of RING-type domain-containing protein vs. Ensembl Zebrafish
Match: trim3b (tripartite motif containing 3b [Source:ZFIN;Acc:ZDB-GENE-070112-1132])

HSP 1 Score: 51.2174 bits (121), Expect = 2.233e-6
Identity = 30/78 (38.46%), Postives = 43/78 (55.13%), Query Frame = 3

Query:  279 IDKLGEILECSIHHGIMTNPKMLSCQHTFCYKCIKDYFKIIQPLLICPICRREENV--DGVEKLPPSYIHNKLMEILK 506
            IDK  + L CSI      NPK+L C HTFC +C+++Y       L CP+CR+   +   GV  L  ++    LME+L+
Sbjct:   20 IDK--QFLVCSICLDHYHNPKVLPCLHTFCERCLQNYIPPQSLTLSCPVCRQTSILPEKGVAALQNNFFITNLMEVLQ 95

[Close]

BLAST of RING-type domain-containing protein vs. Ensembl Zebrafish
Match: trim3b (tripartite motif containing 3b [Source:ZFIN;Acc:ZDB-GENE-070112-1132])

HSP 1 Score: 51.2174 bits (121), Expect = 2.332e-6
Identity = 30/78 (38.46%), Postives = 43/78 (55.13%), Query Frame = 3

Query:  279 IDKLGEILECSIHHGIMTNPKMLSCQHTFCYKCIKDYFKIIQPLLICPICRREENV--DGVEKLPPSYIHNKLMEILK 506
            IDK  + L CSI      NPK+L C HTFC +C+++Y       L CP+CR+   +   GV  L  ++    LME+L+
Sbjct:   20 IDK--QFLVCSICLDHYHNPKVLPCLHTFCERCLQNYIPPQSLTLSCPVCRQTSILPEKGVAALQNNFFITNLMEVLQ 95

[Close]

BLAST of RING-type domain-containing protein vs. Ensembl Zebrafish
Match: trim3a (tripartite motif containing 3a [Source:ZFIN;Acc:ZDB-GENE-080522-4])

HSP 1 Score: 50.8322 bits (120), Expect = 2.947e-6
Identity = 30/78 (38.46%), Postives = 43/78 (55.13%), Query Frame = 3

Query:  279 IDKLGEILECSIHHGIMTNPKMLSCQHTFCYKCIKDYFKIIQPLLICPICRREENV--DGVEKLPPSYIHNKLMEILK 506
            IDK  + L CSI      NPK+L C HTFC +C+++Y       L CP+CR+   +   GV  L  ++    LME+L+
Sbjct:   20 IDK--QFLVCSICLEHYHNPKVLPCLHTFCERCLQNYIPPQSLTLSCPVCRQTSILPEKGVAALQNNFFITNLMEVLQ 95

[Close]

BLAST of RING-type domain-containing protein vs. Ensembl Xenopus
Match: actr6 (ARP6 actin related protein 6 homolog [Source:Xenbase;Acc:XB-GENE-5860964])

HSP 1 Score: 51.2174 bits (121), Expect = 3.599e-6
Identity = 29/78 (37.18%), Postives = 43/78 (55.13%), Query Frame = 3

Query:  279 IDKLGEILECSIHHGIMTNPKMLSCQHTFCYKCIKDYFKIIQPLLICPICRREENV--DGVEKLPPSYIHNKLMEILK 506
            IDK  + L CSI      NPK+L C HTFC +C+++Y       L CP+CR+   +   GV  L  ++    LM++L+
Sbjct:   29 IDK--QFLICSICLDRYKNPKVLPCLHTFCERCLQNYIPAHSLTLSCPVCRQTSILPEKGVSALQNNFFITNLMDVLQ 104

[Close]

BLAST of RING-type domain-containing protein vs. Ensembl Xenopus
Match: actr6 (ARP6 actin related protein 6 homolog [Source:Xenbase;Acc:XB-GENE-5860964])

HSP 1 Score: 51.2174 bits (121), Expect = 3.635e-6
Identity = 29/78 (37.18%), Postives = 43/78 (55.13%), Query Frame = 3

Query:  279 IDKLGEILECSIHHGIMTNPKMLSCQHTFCYKCIKDYFKIIQPLLICPICRREENV--DGVEKLPPSYIHNKLMEILK 506
            IDK  + L CSI      NPK+L C HTFC +C+++Y       L CP+CR+   +   GV  L  ++    LM++L+
Sbjct:   16 IDK--QFLICSICLDRYKNPKVLPCLHTFCERCLQNYIPAHSLTLSCPVCRQTSILPEKGVSALQNNFFITNLMDVLQ 91

[Close]

BLAST of RING-type domain-containing protein vs. Ensembl Xenopus
Match: actr6 (ARP6 actin related protein 6 homolog [Source:Xenbase;Acc:XB-GENE-5860964])

HSP 1 Score: 50.8322 bits (120), Expect = 4.102e-6
Identity = 29/78 (37.18%), Postives = 43/78 (55.13%), Query Frame = 3

Query:  279 IDKLGEILECSIHHGIMTNPKMLSCQHTFCYKCIKDYFKIIQPLLICPICRREENV--DGVEKLPPSYIHNKLMEILK 506
            IDK  + L CSI      NPK+L C HTFC +C+++Y       L CP+CR+   +   GV  L  ++    LM++L+
Sbjct:   16 IDK--QFLICSICLDRYKNPKVLPCLHTFCERCLQNYIPAHSLTLSCPVCRQTSILPEKGVSALQNNFFITNLMDVLQ 91

[Close]

BLAST of RING-type domain-containing protein vs. Ensembl Mouse
Match: Trim2 (tripartite motif-containing 2 [Source:MGI Symbol;Acc:MGI:1933163])

HSP 1 Score: 48.521 bits (114), Expect = 1.259e-6
Identity = 29/78 (37.18%), Postives = 43/78 (55.13%), Query Frame = 3

Query:  279 IDKLGEILECSIHHGIMTNPKMLSCQHTFCYKCIKDYFKIIQPLLICPICRREENVD--GVEKLPPSYIHNKLMEILK 506
            IDK  + L CSI      NPK+L C HTFC +C+++Y       L CP+CR+   +   GV  L  ++    LM++L+
Sbjct:   16 IDK--QFLICSICLERYKNPKVLPCLHTFCERCLQNYIPAHSLTLSCPVCRQTSILPEKGVAALQNNFFITNLMDVLQ 91

[Close]

BLAST of RING-type domain-containing protein vs. Ensembl Mouse
Match: Trim2 (tripartite motif-containing 2 [Source:MGI Symbol;Acc:MGI:1933163])

HSP 1 Score: 50.8322 bits (120), Expect = 3.699e-6
Identity = 29/78 (37.18%), Postives = 43/78 (55.13%), Query Frame = 3

Query:  279 IDKLGEILECSIHHGIMTNPKMLSCQHTFCYKCIKDYFKIIQPLLICPICRREENV--DGVEKLPPSYIHNKLMEILK 506
            IDK  + L CSI      NPK+L C HTFC +C+++Y       L CP+CR+   +   GV  L  ++    LM++L+
Sbjct:   16 IDK--QFLICSICLERYKNPKVLPCLHTFCERCLQNYIPAHSLTLSCPVCRQTSILPEKGVAALQNNFFITNLMDVLQ 91

[Close]

Query:  279 IDKLGEILECSIHHGIMTNPKMLSCQHTFCYKCIKDYFKIIQPLLICPICRREENV--DGVEKLPPSYIHNKLMEILK 506
            IDK  + L CSI      NPK+L C HTFC +C+++Y       L CP+CR+   +   GV  L  ++    LM++L+
Sbjct:   16 IDK--QFLICSICLERYKNPKVLPCLHTFCERCLQNYIPAHSLTLSCPVCRQTSILPEKGVAALQNNFFITNLMDVLQ 91

[Close]

Query:  279 IDKLGEILECSIHHGIMTNPKMLSCQHTFCYKCIKDYFKIIQPLLICPICRREENV--DGVEKLPPSYIHNKLMEILK 506
            IDK  + L CSI      NPK+L C HTFC +C+++Y       L CP+CR+   +   GV  L  ++    LM++L+
Sbjct:   16 IDK--QFLICSICLERYKNPKVLPCLHTFCERCLQNYIPAHSLTLSCPVCRQTSILPEKGVAALQNNFFITNLMDVLQ 91

[Close]

Query:  279 IDKLGEILECSIHHGIMTNPKMLSCQHTFCYKCIKDYFKIIQPLLICPICRREENV--DGVEKLPPSYIHNKLMEILK 506
            IDK  + L CSI      NPK+L C HTFC +C+++Y       L CP+CR+   +   GV  L  ++    LM++L+
Sbjct:   16 IDK--QFLICSICLERYKNPKVLPCLHTFCERCLQNYIPAHSLTLSCPVCRQTSILPEKGVAALQNNFFITNLMDVLQ 91

[Close]

BLAST of RING-type domain-containing protein vs. UniProt/SwissProt
Match: sp|Q03601|NHL1_CAEEL (RING finger protein nhl-1 OS=Caenorhabditis elegans OX=6239 GN=nhl-1 PE=1 SV=2)

HSP 1 Score: 60.4622 bits (145), Expect = 2.384e-8
Identity = 29/76 (38.16%), Postives = 42/76 (55.26%), Query Frame = 3

Query:  279 IDKLGEILECSIHHGIMTNPKMLSCQHTFCYKCIKDYFKIIQPLLICPICRREENV--DGVEKLPPSYIHNKLMEI 500
            ++K+ ++L C I       PK+L CQHTFCY C++     +   L CP CR E N+  DGV+   P+Y     +EI
Sbjct:   34 LEKIEQLLTCPICLDRYKQPKLLPCQHTFCYPCLESCADTLHRNLKCPECRAEHNIPYDGVKAFQPNYTLTGFLEI 109

[Close]

BLAST of RING-type domain-containing protein vs. TrEMBL
Match: A0A267FKZ3 (RING-type domain-containing protein OS=Macrostomum lignano OX=282301 GN=BOX15_Mlig014891g1 PE=4 SV=1)

HSP 1 Score: 89.7373 bits (221), Expect = 3.433e-15
Identity = 75/324 (23.15%), Postives = 147/324 (45.37%), Query Frame = 3

Query:  579 VQQNMVDNSHYQQIYPTEFENVRKIL-SQKNETDFS---LVTANNLNSESSQIVLVDSCTNQITVYST-SGE-STFSIYIDNEIVIPR----YIRVIQNSLYLTG--------------NRKDKGLTVSVFIQSDFHGNVIKRSE--FYVTDSSAFLGFDFNETKNLFYVCMPENKTIQLFDRFLEDYNHCFDLKENSPEFIAFNKQEKQLYISCPLNRRILIYNSET--YKTISTDEI---VPKMIFVTDDEKVLFLDEKANRIIWIKRINDHLLQQQLDLPYLRRDLHIKTFYALSLSMIFIATNDQIFLYQLDQNLSSSNR 1457
            ++ NM  NS Y+ +   +     ++L S + E +     L+   + +++ +++VL++SC+  + VYS+  G+     + I +     R    ++R++   +Y++G                    L+V   +Q D  G V+KR E      D   F GF  +  +    V  P ++ ++ F   L    H F  +   P+++ + ++ K L++SCP    ILI N  T  Y+ ++T +I   VP  I  T D++++F D +  R+ W+ R ++ +  Q+L   +L+    I     L    I + T  +I + +  + L    R
Sbjct:  330 IRHNMKRNSSYK-MKEIDMGTCAELLQSTRGELEIGAAGLLADADGSTDQAELVLLNSCSRSLLVYSSQEGQIKDLPVLIGDSNPGGRLQCHHMRLVNGLVYVSGVAQQQQQQQAADSTGAPTGWLSVVACLQLD--GQVVKRIERPGGSRDEPLFAGFFVDSRRGDMVVAQPSDQKVEFFTPCLGRTGHWFTFENLHPQYVTWTRERKMLWVSCPAEGHILIVNDRTGVYRKLTTTQIFDSVPAHIITTSDKRIIFTDNQRQRLFWVIRRSEFIFVQRLQ--FLQELDEITGIAPLGEDKILVCTRRRICVLKPVRKLRHRKR 648

[Close]

BLAST of RING-type domain-containing protein vs. TrEMBL
Match: A0A267DVM9 (RING-type domain-containing protein OS=Macrostomum lignano OX=282301 GN=BOX15_Mlig023823g1 PE=4 SV=1)

HSP 1 Score: 89.7373 bits (221), Expect = 4.086e-15
Identity = 75/324 (23.15%), Postives = 147/324 (45.37%), Query Frame = 3

Query:  579 VQQNMVDNSHYQQIYPTEFENVRKIL-SQKNETDFS---LVTANNLNSESSQIVLVDSCTNQITVYST-SGE-STFSIYIDNEIVIPR----YIRVIQNSLYLTG--------------NRKDKGLTVSVFIQSDFHGNVIKRSE--FYVTDSSAFLGFDFNETKNLFYVCMPENKTIQLFDRFLEDYNHCFDLKENSPEFIAFNKQEKQLYISCPLNRRILIYNSET--YKTISTDEI---VPKMIFVTDDEKVLFLDEKANRIIWIKRINDHLLQQQLDLPYLRRDLHIKTFYALSLSMIFIATNDQIFLYQLDQNLSSSNR 1457
            ++ NM  NS Y+ +   +     ++L S + E +     L+   + +++ +++VL++SC+  + VYS+  G+     + I +     R    ++R++   +Y++G                    L+V   +Q D  G V+KR E      D   F GF  +  +    V  P ++ ++ F   L    H F  +   P+++ + ++ K L++SCP    ILI N  T  Y+ ++T +I   VP  I  T D++++F D +  R+ W+ R ++ +  Q+L   +L+    I     L    I + T  +I + +  + L    R
Sbjct:  322 IRHNMKRNSSYK-MKEIDMGTCAELLQSTRGELEIGAAGLLADADGSTDQAELVLLNSCSRSLLVYSSQEGQIKDLPVLIGDSNPGGRLQCHHMRLVNGLVYVSGVAQQQQQQQAADSTGAPTGWLSVVACLQLD--GQVVKRIERPGGSRDEPLFAGFFVDSRRGDMVVAQPSDQKVEFFTPCLGRTGHWFTFENLHPQYVTWTRERKMLWVSCPAEGHILIVNDRTGVYRKLTTTQIFDSVPAHIITTSDKRIIFTDNQRQRLFWVIRRSEFIFVQRLQ--FLQELDEITGIAPLGEDKILVCTRRRICVLKPVRKLRHRKR 640

[Close]

BLAST of RING-type domain-containing protein vs. TrEMBL
Match: A0A267GNM7 (RING-type domain-containing protein OS=Macrostomum lignano OX=282301 GN=BOX15_Mlig015500g1 PE=4 SV=1)

HSP 1 Score: 88.9669 bits (219), Expect = 7.122e-15
Identity = 74/324 (22.84%), Postives = 143/324 (44.14%), Query Frame = 3

Query:  579 VQQNMVDNSHYQQIYPTEFENVRKILSQKNETDFS---LVTANNLNSESSQIVLVDSCTNQITVYSTS-GE-STFSIYIDNEIVIPR----YIRVIQNSLYLTG---------------NRKDKGLTVSVFIQSDFHGNVIKRSE--FYVTDSSAFLGFDFNETKNLFYVCMPENKTIQLFDRFLEDYNHCFDLKENSPEFIAFNKQEKQLYISCPLNRRILIYNSET--YKTISTDEI---VPKMIFVTDDEKVLFLDEKANRIIWIKRINDHLLQQQLDLPYLRRDLHIKTFYALSLSMIFIATNDQIFLYQLDQNLSSSNR 1457
            ++ NM  NS Y+            + S + E +     L+   + +++ +++VL++SC+  + VYS+  G+     + I +     R    ++R++   +Y++G                     L+V   +Q D  G V+KR E      D   F GF  +  +    V  P ++ ++ F   L    H F  +   P+++ + ++ K L++SCP    ILI N  T  Y+ ++T +I   VP  I  T D++++F D +  R+ W+ R ++ +  Q+L   +L+    I     L    I + T  +I + +  + L    R
Sbjct:  324 IRHNMKRNSSYKMKEIDMGACADLLQSTRGELEIGAAGLLADADGSTDQAELVLLNSCSRSLLVYSSQEGQIKDLPVLIGDSNPGGRLQCHHMRLVNGLVYVSGVAQQQQQQQQAADSTGAPTGWLSVVACLQLD--GQVVKRIERPGGSRDEPLFAGFFVDSRRGDMVVAQPSDQKVEFFTPCLGRTGHWFTFENLHPQYVTWTRERKMLWVSCPAEGHILIVNDRTGVYRKLTTTQIFDSVPAHIITTSDKRIIFTDNQRQRLFWVIRRSEFIFVQRLQ--FLQELDEITGIAPLGEDKILVCTRRRICVLKPVRKLRHRKR 643

[Close]

BLAST of RING-type domain-containing protein vs. TrEMBL
Match: A0A267ECL9 (RING-type domain-containing protein OS=Macrostomum lignano OX=282301 GN=BOX15_Mlig004309g1 PE=4 SV=1)

HSP 1 Score: 85.5001 bits (210), Expect = 8.378e-14
Identity = 57/248 (22.98%), Postives = 112/248 (45.16%), Query Frame = 3

Query:  723 IVLVDSCTNQITVYSTSGE--STFSIYIDNEIVIPRYIRVIQNSLYLTGNRKDKGLT--VSVFIQSDFHGNVIKRSE----FYVTDSSAFLGFDFNETKNLFYVCMPENKTIQLFDRFLEDYNHCFDLKENSPEFIAFNKQEKQLYISCPLNRRILIYNSET--YKTISTDEI---VPKMIFVTDDEKVLFLDEKANRIIWIKRINDHLLQQQLDLPYLRRDLHIKTFYALSLSMIFIATNDQIFLYQ 1427
            ++L++SC++ + +YS+       F + +    +   Y+      +Y++G       T   S  +     G VI+R E       +D   F GF  +E +    V  P ++ ++     L    H F  +   P  + + ++ + L++SCP    ILI N  T  Y+ ++T +I   VP  I  T D++++F D +  R+ WI R ++ +  Q+L+  +L+    I     L    I + T  +++  +
Sbjct:  354 MILLNSCSHSLLLYSSQDGRLKDFPVVLGGHRMRCYYMTFSNGLVYVSGVVPSDSATRWTSAIVCVQLDGLVIRRLERPGAAAGSDEPLFAGFHVDERRGELVVAQPADQKVEFLTPALARTGHWFTFENLHPHHVTWTRERRMLWVSCPSEGHILIVNDRTGVYRKLTTTQIFDSVPAHIITTSDKRIIFTDNQRQRVFWIIRRSEFIFVQRLE--FLQELADITGIAPLGEDKILVCTKRKLYFLK 599

[Close]

BLAST of RING-type domain-containing protein vs. TrEMBL
Match: A0A267DTD7 (RING-type domain-containing protein OS=Macrostomum lignano OX=282301 GN=BOX15_Mlig004309g2 PE=4 SV=1)

HSP 1 Score: 84.7297 bits (208), Expect = 1.376e-13
Identity = 57/248 (22.98%), Postives = 111/248 (44.76%), Query Frame = 3

Query:  723 IVLVDSCTNQITVYSTSGE--STFSIYIDNEIVIPRYIRVIQNSLYLTGNRKDKGLT--VSVFIQSDFHGNVIKRSE----FYVTDSSAFLGFDFNETKNLFYVCMPENKTIQLFDRFLEDYNHCFDLKENSPEFIAFNKQEKQLYISCPLNRRILIYNSET--YKTISTDEI---VPKMIFVTDDEKVLFLDEKANRIIWIKRINDHLLQQQLDLPYLRRDLHIKTFYALSLSMIFIATNDQIFLYQ 1427
            ++L++SC++ + +YS+       F + +    +   Y+      +Y++G       T   S        G VI+R E       +D   F GF  +E +    V  P ++ ++     L    H F  +   P  + + ++ + L++SCP    ILI N  T  Y+ ++T +I   VP  I  T D++++F D +  R+ WI R ++ +  Q+L+  +L+    I     L    I + T  +++  +
Sbjct:  354 MILLNSCSHSLLLYSSQDGRLKDFPVVLGGHRMRCYYMTFTNGLVYVSGVVPSDSATRWTSAIACVQLDGLVIRRLERPGAAAGSDEPLFAGFHVDERRGELVVAQPADQKVEFLTPALARTGHWFTFENLHPHHVTWTRERRMLWVSCPSEGHILIVNDRTGVYRKLTTTQIFDSVPAHIITTSDKRIIFTDNQRQRVFWIIRRSEFIFVQRLE--FLQELADITGIAPLGEDKILVCTKRKLYFLK 599

[Close]

BLAST of RING-type domain-containing protein vs. Ensembl Cavefish
Match: trim2a (tripartite motif containing 2 [Source:NCBI gene;Acc:103036279])

HSP 1 Score: 53.9138 bits (128), Expect = 2.881e-7
Identity = 31/78 (39.74%), Postives = 43/78 (55.13%), Query Frame = 3

Query:  279 IDKLGEILECSIHHGIMTNPKMLSCQHTFCYKCIKDYFKIIQPLLICPICRREENV--DGVEKLPPSYIHNKLMEILK 506
            IDK  + L CSI      NPK+L C HTFC +C+++Y       L CP+CR+   +   GV  L  ++    LME+LK
Sbjct:   16 IDK--QFLICSICLDRYDNPKVLPCLHTFCERCLQNYIPAHSLTLSCPVCRQTSILPEKGVAALQSNFFITNLMEVLK 91

[Close]

BLAST of RING-type domain-containing protein vs. Ensembl Cavefish
Match: trim2a (tripartite motif containing 2 [Source:NCBI gene;Acc:103036279])

HSP 1 Score: 53.9138 bits (128), Expect = 3.023e-7
Identity = 31/78 (39.74%), Postives = 43/78 (55.13%), Query Frame = 3

Query:  279 IDKLGEILECSIHHGIMTNPKMLSCQHTFCYKCIKDYFKIIQPLLICPICRREENV--DGVEKLPPSYIHNKLMEILK 506
            IDK  + L CSI      NPK+L C HTFC +C+++Y       L CP+CR+   +   GV  L  ++    LME+LK
Sbjct:   16 IDK--QFLICSICLDRYDNPKVLPCLHTFCERCLQNYIPAHSLTLSCPVCRQTSILPEKGVAALQSNFFITNLMEVLK 91

[Close]

BLAST of RING-type domain-containing protein vs. Ensembl Cavefish
Match: trim2a (tripartite motif containing 2 [Source:NCBI gene;Acc:103036279])

HSP 1 Score: 53.9138 bits (128), Expect = 3.023e-7
Identity = 31/78 (39.74%), Postives = 43/78 (55.13%), Query Frame = 3

Query:  279 IDKLGEILECSIHHGIMTNPKMLSCQHTFCYKCIKDYFKIIQPLLICPICRREENV--DGVEKLPPSYIHNKLMEILK 506
            IDK  + L CSI      NPK+L C HTFC +C+++Y       L CP+CR+   +   GV  L  ++    LME+LK
Sbjct:   16 IDK--QFLICSICLDRYDNPKVLPCLHTFCERCLQNYIPAHSLTLSCPVCRQTSILPEKGVAALQSNFFITNLMEVLK 91

[Close]

BLAST of RING-type domain-containing protein vs. Ensembl Cavefish
Match: trim2a (tripartite motif containing 2 [Source:NCBI gene;Acc:103036279])

HSP 1 Score: 53.9138 bits (128), Expect = 3.023e-7
Identity = 31/78 (39.74%), Postives = 43/78 (55.13%), Query Frame = 3

Query:  279 IDKLGEILECSIHHGIMTNPKMLSCQHTFCYKCIKDYFKIIQPLLICPICRREENV--DGVEKLPPSYIHNKLMEILK 506
            IDK  + L CSI      NPK+L C HTFC +C+++Y       L CP+CR+   +   GV  L  ++    LME+LK
Sbjct:   16 IDK--QFLICSICLDRYDNPKVLPCLHTFCERCLQNYIPAHSLTLSCPVCRQTSILPEKGVAALQSNFFITNLMEVLK 91

[Close]

BLAST of RING-type domain-containing protein vs. Ensembl Cavefish
Match: ENSAMXT00000055241.1 (pep primary_assembly:Astyanax_mexicanus-2.0:3:9979781:9985466:1 gene:ENSAMXG00000040777.1 transcript:ENSAMXT00000055241.1 gene_biotype:protein_coding transcript_biotype:protein_coding)

HSP 1 Score: 47.3654 bits (111), Expect = 9.582e-7
Identity = 19/63 (30.16%), Postives = 36/63 (57.14%), Query Frame = 3

Query:  264 TKSEIIDKLGEILECSIHHGIMTNPKMLSCQHTFCYKCIKDYFKIIQPL--LICPICRREENV 446
            T +E++ +     +CS+   ++++P  + C H++C +CI+DY+  + P     CP CRR   V
Sbjct:    3 TPAELLSRSPSTKDCSVCLDLLSDPVTVPCGHSYCLRCIRDYWDQMGPAGGCFCPQCRRRFRV 65

[Close]

BLAST of RING-type domain-containing protein vs. Ensembl Yeast
Match: PSH1 (E3 ubiquitin ligase targeting centromere-binding protein Cse4p; mediates polyubiquitination and degradation of histone H3 variant Cse4p, preventing its mislocalization to euchromatin independent of Slx5p; ubiquitination of Cse4p may be antagonized by Scm3p [Source:SGD;Acc:S000005415])

HSP 1 Score: 51.2174 bits (121), Expect = 1.747e-7
Identity = 27/63 (42.86%), Postives = 32/63 (50.79%), Query Frame = 3

Query:  246 LFMEDLTKSEIIDKLGEILECSIHHGIMTNPKMLSCQHTFCYKCIKDYFKI-IQPLLICPICR 431
            L   D TK  I+ K+ E L CSI H  M  P M  C H +CY C+  +F    Q  L CP CR
Sbjct:   10 LHQNDGTKDAILYKIIESLVCSICHDYMFVPMMTPCGHNYCYGCLNTWFASNTQKELACPQCR 72

[Close]

BLAST of RING-type domain-containing protein vs. Ensembl Nematostella
Match: EDO47642 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7RLP9])

HSP 1 Score: 57.3806 bits (137), Expect = 9.418e-9
Identity = 27/76 (35.53%), Postives = 42/76 (55.26%), Query Frame = 3

Query:  300 LECSIHHGIMTNPKMLSCQHTFCYKCIK--DYFKIIQPLLICPICRREENV--DGVEKLPPSYIHNKLMEILKLKT 515
            L C   H + T PK+L C HTFC KC+   D        ++CP+CR+   +   GVE LP +++ N  ++ L +K+
Sbjct:   14 LNCRACHKVFTEPKILDCLHTFCQKCLGTHDILGAGTNSIVCPLCRKPTPIPESGVESLPSNFLLNNALDQLSVKS 89

[Close]

BLAST of RING-type domain-containing protein vs. Ensembl Nematostella
Match: EDO47311 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7RMQ9])

HSP 1 Score: 53.5286 bits (127), Expect = 1.352e-7
Identity = 27/77 (35.06%), Postives = 47/77 (61.04%), Query Frame = 3

Query:  282 DKLGEILECSIHHGIMTNPKMLSCQHTFCYKCIKDYFKIIQPLLICPICRREENV---DGVEKLPPSYIHNKLMEIL 503
            +K+ E L CS+       PKML C HTFC +C++   +  +  L+CP CR + +V   + ++KLP ++I N++++ L
Sbjct:   14 EKVREELTCSVCLEQFREPKMLPCFHTFCKECLEKTKQSFRGNLLCPTCRTKTSVTEHEMIQKLPNNFIVNRVLDAL 90

[Close]

BLAST of RING-type domain-containing protein vs. Ensembl Nematostella
Match: EDO47715 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7RLM1])

HSP 1 Score: 51.9878 bits (123), Expect = 4.600e-7
Identity = 28/80 (35.00%), Postives = 45/80 (56.25%), Query Frame = 3

Query:  279 IDKLGE-ILECSIHHGIMTNPKMLSCQHTFCYKCIKDYFKIIQPLLICPICRREENV--DGVEKLPPSYIHNKLMEILKL 509
            +DKL E +L+C I       PK+L C HTFC  C+K   +  + +++CP CR E  V  +GV  L  ++  N +++ L +
Sbjct:    6 VDKLSEHLLKCPICLETYRTPKVLPCLHTFCQHCLKGMIQSGENIIVCPTCRCEVCVPKEGVSALSTNFFINNMLDFLSV 85

[Close]

BLAST of RING-type domain-containing protein vs. Ensembl Nematostella
Match: EDO47716 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7RLM3])

HSP 1 Score: 49.2914 bits (116), Expect = 1.447e-6
Identity = 28/80 (35.00%), Postives = 45/80 (56.25%), Query Frame = 3

Query:  279 IDKLGE-ILECSIHHGIMTNPKMLSCQHTFCYKCIKDYFKIIQPLLICPICRREENV--DGVEKLPPSYIHNKLMEILKL 509
            +DKL E +L+C I       PK+L C HTFC  C+K   +  + +++CP CR E  V  +GV  L  ++  N +++ L +
Sbjct:    6 VDKLSEHLLKCPICLETYRTPKVLPCLHTFCQHCLKGMIQSGENIIVCPTCRCEVCVPKEGVSALSTNFFINNMLDFLSV 85

[Close]

BLAST of RING-type domain-containing protein vs. Ensembl Nematostella
Match: EDO37391 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7SFU8])

HSP 1 Score: 47.3654 bits (111), Expect = 2.287e-6
Identity = 22/59 (37.29%), Postives = 35/59 (59.32%), Query Frame = 3

Query:  297 ILECSIHHGIMTNPKMLSCQHTFCYKCIKDYFKIIQPLLICPICRREENV--DGVEKLP 467
            I++C +      +P++L CQH+FC KC+    K  + L++CP CRRE  +   GV+  P
Sbjct:    4 IIKCPVCLETFDDPRVLPCQHSFCKKCVTGVAKARRGLVVCPQCRRESWLPRKGVKGYP 62

[Close]

BLAST of RING-type domain-containing protein vs. Ensembl Medaka
Match: trim3a (tripartite motif-containing protein 3 [Source:NCBI gene;Acc:101175583])

HSP 1 Score: 52.7582 bits (125), Expect = 7.147e-7
Identity = 31/78 (39.74%), Postives = 43/78 (55.13%), Query Frame = 3

Query:  279 IDKLGEILECSIHHGIMTNPKMLSCQHTFCYKCIKDYFKIIQPLLICPICRREENV--DGVEKLPPSYIHNKLMEILK 506
            IDK  + L CSI      NPK+L C HTFC KC+++Y       L CP+CR+   +   GV  L  ++    LME+L+
Sbjct:   20 IDK--QFLVCSICLDRYHNPKVLPCLHTFCEKCLQNYIPPQSLTLSCPVCRQTSILPEKGVAALQNNFFITNLMEVLQ 95

[Close]

BLAST of RING-type domain-containing protein vs. Ensembl Medaka
Match: trim3a (tripartite motif-containing protein 3 [Source:NCBI gene;Acc:101175583])

HSP 1 Score: 52.7582 bits (125), Expect = 7.206e-7
Identity = 31/78 (39.74%), Postives = 43/78 (55.13%), Query Frame = 3

Query:  279 IDKLGEILECSIHHGIMTNPKMLSCQHTFCYKCIKDYFKIIQPLLICPICRREENV--DGVEKLPPSYIHNKLMEILK 506
            IDK  + L CSI      NPK+L C HTFC KC+++Y       L CP+CR+   +   GV  L  ++    LME+L+
Sbjct:   20 IDK--QFLVCSICLDRYHNPKVLPCLHTFCEKCLQNYIPPQSLTLSCPVCRQTSILPEKGVAALQNNFFITNLMEVLQ 95

[Close]

BLAST of RING-type domain-containing protein vs. Ensembl Medaka
Match: trim2a (tripartite motif containing 2 [Source:NCBI gene;Acc:101163547])

HSP 1 Score: 51.2174 bits (121), Expect = 1.991e-6
Identity = 29/78 (37.18%), Postives = 43/78 (55.13%), Query Frame = 3

Query:  279 IDKLGEILECSIHHGIMTNPKMLSCQHTFCYKCIKDYFKIIQPLLICPICRREENV--DGVEKLPPSYIHNKLMEILK 506
            IDK  + L CSI      NPK+L C HTFC +C+++Y       L CP+CR+   +   GV  L  ++    LM++L+
Sbjct:   16 IDK--QFLICSICLDRYENPKVLPCLHTFCERCLQNYIPAHSLTLSCPVCRQTSILPEKGVAALQSNFFITNLMDVLQ 91

[Close]

Query:  279 IDKLGEILECSIHHGIMTNPKMLSCQHTFCYKCIKDYFKIIQPLLICPICRREENV--DGVEKLPPSYIHNKLMEILK 506
            IDK  + L CSI      NPK+L C HTFC +C+++Y       L CP+CR+   +   GV  L  ++    LM++L+
Sbjct:   16 IDK--QFLICSICLDRYENPKVLPCLHTFCERCLQNYIPAHSLTLSCPVCRQTSILPEKGVAALQSNFFITNLMDVLQ 91

[Close]

Query:  279 IDKLGEILECSIHHGIMTNPKMLSCQHTFCYKCIKDYFKIIQPLLICPICRREENV--DGVEKLPPSYIHNKLMEILK 506
            IDK  + L CSI      NPK+L C HTFC +C+++Y       L CP+CR+   +   GV  L  ++    LM++L+
Sbjct:   16 IDK--QFLICSICLDRYENPKVLPCLHTFCERCLQNYIPAHSLTLSCPVCRQTSILPEKGVAALQSNFFITNLMDVLQ 91

[Close]

BLAST of RING-type domain-containing protein vs. Planmine SMEST
Match: SMESG000069649.1 (SMESG000069649.1)

HSP 1 Score: 789.645 bits (2038), Expect = 0.000e+0
Identity = 402/410 (98.05%), Postives = 404/410 (98.54%), Query Frame = 3

Query:  252 MEDLTKSEIIDKLGEILECSIHHGIMTNPKMLSCQHTFCYKCIKDYFKIIQPLLICPICRREENVDGVEKLPPSYIHNKLMEILKLKTKXXXXXXXXXXXXXXXWKIETVQQNMVDNSHYQQIYPTEFENVRKILSQKNETDFSLVTANNLNSESSQIVLVDSCTNQITVYSTSGESTFSIYIDNEIVIPRYIRVIQNSLYLTGNRKDKGLTVSVFIQSDFHGNVIKRSEFYVTDSSAFLGFDFNETKNLFYVCMPENKTIQLFDRFLEDYNHCFDLKENSPEFIAFNKQEKQLYISCPLNRRILIYNSETYKTISTDEIVPKMIFVTDDEKVLFLDEKANRIIWIKRINDHLLQQQLDLPYLRRDLHIKTFYALSLSMIFIATNDQIFLYQLDQNLSSSNRVSPFCNLS 1481
            M+DLTKSEIIDKLGEILECSIHHGIMTNPKMLSCQHTFCYKCIKDYFKIIQPLLICPICRREENVDGVEKLPPSYIHNKLMEILKLKTKSESN DDSDSENDSEWKIETVQQNMVDNSHYQQIY TEFENVR ILSQKNETDFSLVTANNLNSESSQIV VDSCTNQITVYSTSGESTFSIYIDNEIVIPRYIRVIQNSLYLTGNRKDKGLTVSVF+QSDFHGNVIKRSEFYVTDSSAFLGFDFNETKNLFYVCMPENKTIQLFDRFLEDYNHCFDLKENSPEFIAFNKQEKQLYISCPLNRRILIYNSETYKTISTDEIVPKMIFVTDDEKVLFLDEKANRIIWIKRINDHLLQQQL LPYLRRDLHIKTFY LSLSMIFIATNDQIFLYQLDQNLSSSNRVSPFCNLS
Sbjct:    1 MDDLTKSEIIDKLGEILECSIHHGIMTNPKMLSCQHTFCYKCIKDYFKIIQPLLICPICRREENVDGVEKLPPSYIHNKLMEILKLKTKSESNTDDSDSENDSEWKIETVQQNMVDNSHYQQIYLTEFENVRGILSQKNETDFSLVTANNLNSESSQIVFVDSCTNQITVYSTSGESTFSIYIDNEIVIPRYIRVIQNSLYLTGNRKDKGLTVSVFLQSDFHGNVIKRSEFYVTDSSAFLGFDFNETKNLFYVCMPENKTIQLFDRFLEDYNHCFDLKENSPEFIAFNKQEKQLYISCPLNRRILIYNSETYKTISTDEIVPKMIFVTDDEKVLFLDEKANRIIWIKRINDHLLQQQLYLPYLRRDLHIKTFYVLSLSMIFIATNDQIFLYQLDQNLSSSNRVSPFCNLS 410

[Close]

BLAST of RING-type domain-containing protein vs. Planmine SMEST
Match: SMESG000069646.1 (SMESG000069646.1)

HSP 1 Score: 207.223 bits (526), Expect = 2.347e-60
Identity = 118/320 (36.88%), Postives = 195/320 (60.94%), Query Frame = 3

Query:  570 IETVQQNMVDNSHYQQIYPTEF----ENVRKILSQKNETDFSLVTAN--NLNSESSQIVLVDSCTNQITVYSTSGESTFSIYIDNEIVIPRYIRVIQNSLYLTGNRKDKGLTV-SVFIQSDFHGNVIKRSEFYV----TDSSAFLGFDFNETKNLFYVCMPENKTIQLFD-RFLEDYNHCFDLKENSPEFIAFNKQEKQLYISCPLNRRILIYN--SETYKTISTDEI---VPKMIFVTDDEKVLFLDEKANRIIWIKRINDHLLQQQLDLPYLRRDLHIKTFYALSLSMIFIATNDQIFLYQLDQNLSSSNRVSPFCNL 1478
            IET+++NM+  S Y+ +         +N+ ++  + ++ +FS+   N    + + S +VLVDS ++Q+ VYS S   TF I + N+I+ P YIR+ Q +L LTG R D+   + S+F+Q    G ++++SE Y+     D    +GFD NE +  +Y+CMP + +++++   F+E + + ++  EN PE+IAF+  + QL+ISCP NRRILI +  S  ++  +T++I   +PKMIFVTDDEK++FLD   NR IWIKR N+++L Q+L+   + RD  IK F  L  S + +   ++I ++Q  +  S S R+   CN 
Sbjct:  202 IETIRENMLKYSQYEVVKRDGVHKICKNIHQLQKESSQFEFSIFDINISATHPKLSHLVLVDSKSHQLLVYSDSNIKTFHIVLKNDIIKPEYIRIYQGNLILTG-RLDRNEEIGSIFLQCSMCGKILRQSELYIWPNTPDLPMMMGFDINEKEEKYYLCMPNSGSVRIYSTNFIESHQY-YEFDENRPEYIAFSSTQNQLWISCPRNRRILILDLDSGIFRLFNTEQINKAIPKMIFVTDDEKIIFLDITGNRFIWIKRRNEYILTQKLNFLSINRDSTIKNFLVLPCSRVTVGVENEILVFQSTKYFSKSRRIFELCNF 519

HSP 2 Score: 78.1814 bits (191), Expect = 3.638e-15
Identity = 37/82 (45.12%), Postives = 53/82 (64.63%), Query Frame = 3

Query:  267 KSEIID---KLGEILECSIHHGIMTNPKMLSCQHTFCYKCIKDYFKIIQPLLICPICRREENVDGVEKLPPSYIHNKLMEIL 503
            +SE  D   +L EI+ C IH GIM +P+ L CQH FCY C+K+Y KI    LICPICR +E  + ++KLP +    +L+ ++
Sbjct:   39 RSETFDNTRELEEIVTCCIHLGIMNDPRKLFCQHAFCYNCLKEYSKICVD-LICPICRVKEKTNDIDKLPSALTEKQLISVV 119

[Close]

BLAST of RING-type domain-containing protein vs. Planmine SMEST
Match: SMESG000020467.1 (SMESG000020467.1)

HSP 1 Score: 97.0561 bits (240), Expect = 3.530e-21
Identity = 75/292 (25.68%), Postives = 139/292 (47.60%), Query Frame = 3

Query:  570 IETVQQNMVDNSHYQQIYPTEFENVRKILSQKNETDFSLVTANNLNSESSQIVLVDSCTNQITVYSTSGE-STFSIYIDNEIVIPRYIRVIQNSLYLTGNRKDKGLTVSVF--IQSDFHGNVIKRSEFYVTD--SSAFLGFDFNETKNLFYVCMPENKTIQLFDRFLEDYNHCFDLKENSPEFIAFNKQEKQLYISCPLNRRILIYNSET--YKTISTDEI---VPKMIFVTDDEKVLFLDEKANRIIWIKRINDHLLQQQLDLPYLRRDLHIKTFYALSLSMIFIATNDQI 1415
            +ET+++NM   S Y+ +       V    S +N+   + +    LN E+  IV      N I V +       F+I ID+  V P ++++  N L+L+G  ++       +  IQS   G +I  S F  +   ++   GF  +       + +P+   I +    L + +H +   +  P FI  N+   +++ SCP + RI+I + ET  Y+ + TD+I   +P  I ++ D +V+FLD + NR+ W+++ ND +L Q+++        H K       +M+ I+  D +
Sbjct:  224 VETIRENMRKYSEYKLLRDVNHSIVNFHSSGRNKMIIADIKL--LNHEAEVIVWTSVHGNLIAVKTPDHSVHDFTIQIDSCEVKPIFLKIYNNDLFLSGYIENSATKEKHYYLIQSSLTGELIHTSVFNSSHDITTKIAGFHIDPGSGKILLAIPDACKIAILTSNLVETSHGYHFTDLHPSFITQNQDTAEIWASCPQDGRIIIIDEETGSYRQLGTDQIYNAIPSHITISGDNRVMFLDCRQNRVFWVRKRNDFILIQRINFI----GHHNKQLNGKMTAMVAISGTDTL 509

HSP 2 Score: 51.2174 bits (121), Expect = 1.304e-6
Identity = 30/87 (34.48%), Postives = 50/87 (57.47%), Query Frame = 3

Query:  279 IDKLGEILECSIHHGIMTNPKMLSCQHTFCYKCIKDYFKIIQPLL----ICPICRREENVD--GVEKLPPSYIHNKLME-ILKLKTK 518
            + KL +++ C IH G+M +P++L C H FC  C+  Y  +I+  +     CP+CRR   +D   V  LPPS    +L + I++ K++
Sbjct:   45 MSKLEDLIMCPIHLGMMEDPRILPCGHAFCLNCL--YSCLIRMSISVNFSCPVCRRYCEIDQKTVCLLPPSIATKQLTDYIVETKSR 129

[Close]

BLAST of RING-type domain-containing protein vs. Planmine SMEST
Match: SMESG000064098.1 (SMESG000064098.1)

HSP 1 Score: 92.4337 bits (228), Expect = 1.204e-19
Identity = 63/221 (28.51%), Postives = 113/221 (51.13%), Query Frame = 3

Query:  783 TFSIYIDNEIVIPRYIRVIQNSLYLTGNRKDKGL-TVSVFIQSDFHGNVIKRSEFYVTDSSAFLGFDFNETKNLFYVCMPENKTIQLFDRFLEDYNHCFDLKENSPEFIAFNKQEKQLYISCPLNRRILIYN--SETYKTISTDEI---VPKMIFVTDDEKVLFLDEKANRIIWIKRINDHLLQQQLDLPYLRRDLHIKTFYALSLSMIFIATNDQIFLYQ 1427
            +F I ++N  + P +I+   N ++++G     GL   S  IQ   +G     S  Y   S  F GF F+ T N  +V  P    + L D  LE     F+    SP F+A + + +++++SCP + RI +Y+  ++ Y  ++T++I    P  I  T D ++LFLD   +R+ WI R N  L  Q +++   + ++ I T  ++S +MI  +  ++ F+ +
Sbjct:  309 SFFISVENSKIFPIFIKCFLNKIFVSGK---IGLDQSSCLIQLSLNGERENISPIY---SGLFGGFCFDLTNNSIFVAYPSRNQVILLDNSLEKELKVFEFGNLSPMFVAISFKTREIWVSCPNDGRIAVYDEMTDNYLHLATNQIYESTPTHIIETLDHRLLFLDVGKSRLFWIFRWNSCLYIQLINVNGSKEEIKINTVQSISENMILFSDGNKTFIAR 523

HSP 2 Score: 62.7734 bits (151), Expect = 2.966e-10
Identity = 30/96 (31.25%), Postives = 50/96 (52.08%), Query Frame = 3

Query:  234 ILYKLFMEDLTKSEIIDKLGEILECSIHHGIMTNPKMLSCQHTFCYKCIKDY----FKIIQPLLICPICRREENVD--GVEKLPPSYIHNKLMEIL 503
            +  K+F +   +   I+ L ++L C IH G +  P+ L C H FC  C++ Y     +     + CP+CR    +D  G++ L PS++H +L E L
Sbjct:   37 VCSKVFHKSNNEFSSIENLEDLLTCPIHLGAIDEPRQLQCGHVFCLSCLESYASHGLETSPKQICCPLCRNHTQLDHKGIKSLAPSFLHKQLTEYL 132

[Close]

BLAST of RING-type domain-containing protein vs. Planmine SMEST
Match: SMESG000064098.1 (SMESG000064098.1)

HSP 1 Score: 92.0485 bits (227), Expect = 1.257e-19
Identity = 63/221 (28.51%), Postives = 113/221 (51.13%), Query Frame = 3

Query:  783 TFSIYIDNEIVIPRYIRVIQNSLYLTGNRKDKGL-TVSVFIQSDFHGNVIKRSEFYVTDSSAFLGFDFNETKNLFYVCMPENKTIQLFDRFLEDYNHCFDLKENSPEFIAFNKQEKQLYISCPLNRRILIYN--SETYKTISTDEI---VPKMIFVTDDEKVLFLDEKANRIIWIKRINDHLLQQQLDLPYLRRDLHIKTFYALSLSMIFIATNDQIFLYQ 1427
            +F I ++N  + P +I+   N ++++G     GL   S  IQ   +G     S  Y   S  F GF F+ T N  +V  P    + L D  LE     F+    SP F+A + + +++++SCP + RI +Y+  ++ Y  ++T++I    P  I  T D ++LFLD   +R+ WI R N  L  Q +++   + ++ I T  ++S +MI  +  ++ F+ +
Sbjct:  300 SFFISVENSKIFPIFIKCFLNKIFVSGK---IGLDQSSCLIQLSLNGERENISPIY---SGLFGGFCFDLTNNSIFVAYPSRNQVILLDNSLEKELKVFEFGNLSPMFVAISFKTREIWVSCPNDGRIAVYDEMTDNYLHLATNQIYESTPTHIIETLDHRLLFLDVGKSRLFWIFRWNSCLYIQLINVNGSKEEIKINTVQSISENMILFSDGNKTFIAR 514

HSP 2 Score: 63.1586 bits (152), Expect = 2.566e-10
Identity = 30/96 (31.25%), Postives = 50/96 (52.08%), Query Frame = 3

Query:  234 ILYKLFMEDLTKSEIIDKLGEILECSIHHGIMTNPKMLSCQHTFCYKCIKDY----FKIIQPLLICPICRREENVD--GVEKLPPSYIHNKLMEIL 503
            +  K+F +   +   I+ L ++L C IH G +  P+ L C H FC  C++ Y     +     + CP+CR    +D  G++ L PS++H +L E L
Sbjct:   28 VCSKVFHKSNNEFSSIENLEDLLTCPIHLGAIDEPRQLQCGHVFCLSCLESYASHGLETSPKQICCPLCRNHTQLDHKGIKSLAPSFLHKQLTEYL 123

The following BLAST results are available for this feature:

BLAST of RING-type domain-containing protein vs. Ensembl Human
BLAST of RING-type domain-containing protein vs. Ensembl Celegans
BLAST of RING-type domain-containing protein vs. Ensembl Fly
BLAST of RING-type domain-containing protein vs. Ensembl Zebrafish
BLAST of RING-type domain-containing protein vs. Ensembl Xenopus
BLAST of RING-type domain-containing protein vs. Ensembl Mouse
BLAST of RING-type domain-containing protein vs. UniProt/SwissProt
BLAST of RING-type domain-containing protein vs. TrEMBL
BLAST of RING-type domain-containing protein vs. Ensembl Cavefish
BLAST of RING-type domain-containing protein vs. Ensembl Sea Lamprey
BLAST of RING-type domain-containing protein vs. Ensembl Yeast
BLAST of RING-type domain-containing protein vs. Ensembl Nematostella
BLAST of RING-type domain-containing protein vs. Ensembl Medaka
BLAST of RING-type domain-containing protein vs. Planmine SMEST

BLAST of RING-type domain-containing protein vs. Ensembl Human
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Human e!99)
Total hits: 5


Match Name	E-value	Identity	Description
TRIM3	7.076e-7	32.56	tripartite motif containing 3 [Source:HGNC Symbol;...	[more]
TRIM2	2.514e-6	37.18	tripartite motif containing 2 [Source:HGNC Symbol;...	[more]
TRIM2	2.514e-6	37.18	tripartite motif containing 2 [Source:HGNC Symbol;...	[more]
TRIM2	3.261e-6	37.18	tripartite motif containing 2 [Source:HGNC Symbol;...	[more]
TRIM2	5.529e-6	37.18	tripartite motif containing 2 [Source:HGNC Symbol;...	[more]

BLAST of RING-type domain-containing protein vs. Ensembl Celegans
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99)
Total hits: 2


Match Name	E-value	Identity	Description
nhl-1	1.827e-9	38.16	RING finger protein nhl-1 [Source:UniProtKB/Swiss...	[more]
nhl-1	1.874e-9	38.16	RING finger protein nhl-1 [Source:UniProtKB/Swiss...	[more]

BLAST of RING-type domain-containing protein vs. Ensembl Fly
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99)
Total hits: 0


Match Name	E-value	Identity	Description

BLAST of RING-type domain-containing protein vs. Ensembl Zebrafish
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99)
Total hits: 5


Match Name	E-value	Identity	Description
trim2a	3.500e-7	39.74	tripartite motif containing 2a [Source:ZFIN;Acc:ZD...	[more]
trim59	1.912e-6	37.33	tripartite motif containing 59 [Source:ZFIN;Acc:ZD...	[more]
trim3b	2.233e-6	38.46	tripartite motif containing 3b [Source:ZFIN;Acc:ZD...	[more]
trim3b	2.332e-6	38.46	tripartite motif containing 3b [Source:ZFIN;Acc:ZD...	[more]
trim3a	2.947e-6	38.46	tripartite motif containing 3a [Source:ZFIN;Acc:ZD...	[more]

BLAST of RING-type domain-containing protein vs. Ensembl Xenopus
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99)
Total hits: 3


Match Name	E-value	Identity	Description
actr6	3.599e-6	37.18	ARP6 actin related protein 6 homolog [Source:Xenba...	[more]
actr6	3.635e-6	37.18	ARP6 actin related protein 6 homolog [Source:Xenba...	[more]
actr6	4.102e-6	37.18	ARP6 actin related protein 6 homolog [Source:Xenba...	[more]

BLAST of RING-type domain-containing protein vs. Ensembl Mouse
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99)
Total hits: 5


Match Name	E-value	Identity	Description
Trim2	1.259e-6	37.18	tripartite motif-containing 2 [Source:MGI Symbol;A...	[more]
Trim2	3.699e-6	37.18	tripartite motif-containing 2 [Source:MGI Symbol;A...	[more]
Trim2	3.699e-6	37.18	tripartite motif-containing 2 [Source:MGI Symbol;A...	[more]
Trim2	3.699e-6	37.18	tripartite motif-containing 2 [Source:MGI Symbol;A...	[more]
Trim2	3.699e-6	37.18	tripartite motif-containing 2 [Source:MGI Symbol;A...	[more]

BLAST of RING-type domain-containing protein vs. UniProt/SwissProt
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt)
Total hits: 1


Match Name	E-value	Identity	Description
sp\|Q03601\|NHL1_CAEEL	2.384e-8	38.16	RING finger protein nhl-1 OS=Caenorhabditis elegan...	[more]

BLAST of RING-type domain-containing protein vs. TrEMBL
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL)
Total hits: 5


Match Name	E-value	Identity	Description
A0A267FKZ3	3.433e-15	23.15	RING-type domain-containing protein OS=Macrostomum...	[more]
A0A267DVM9	4.086e-15	23.15	RING-type domain-containing protein OS=Macrostomum...	[more]
A0A267GNM7	7.122e-15	22.84	RING-type domain-containing protein OS=Macrostomum...	[more]
A0A267ECL9	8.378e-14	22.98	RING-type domain-containing protein OS=Macrostomum...	[more]
A0A267DTD7	1.376e-13	22.98	RING-type domain-containing protein OS=Macrostomum...	[more]

BLAST of RING-type domain-containing protein vs. Ensembl Cavefish
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99)
Total hits: 5


Match Name	E-value	Identity	Description
trim2a	2.881e-7	39.74	tripartite motif containing 2 [Source:NCBI gene;Ac...	[more]
trim2a	3.023e-7	39.74	tripartite motif containing 2 [Source:NCBI gene;Ac...	[more]
trim2a	3.023e-7	39.74	tripartite motif containing 2 [Source:NCBI gene;Ac...	[more]
trim2a	3.023e-7	39.74	tripartite motif containing 2 [Source:NCBI gene;Ac...	[more]
ENSAMXT00000055241.1	9.582e-7	30.16	pep primary_assembly:Astyanax_mexicanus-2.0:3:9979...	[more]

BLAST of RING-type domain-containing protein vs. Ensembl Sea Lamprey
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99)
Total hits: 0


Match Name	E-value	Identity	Description

BLAST of RING-type domain-containing protein vs. Ensembl Yeast
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46)
Total hits: 1


Match Name	E-value	Identity	Description
PSH1	1.747e-7	42.86	E3 ubiquitin ligase targeting centromere-binding p...	[more]

BLAST of RING-type domain-containing protein vs. Ensembl Nematostella
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46)
Total hits: 5


Match Name	E-value	Identity	Description
EDO47642	9.418e-9	35.53	Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7...	[more]
EDO47311	1.352e-7	35.06	Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7...	[more]
EDO47715	4.600e-7	35.00	Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7...	[more]
EDO47716	1.447e-6	35.00	Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7...	[more]
EDO37391	2.287e-6	37.29	Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7...	[more]

BLAST of RING-type domain-containing protein vs. Ensembl Medaka
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99)
Total hits: 5


Match Name	E-value	Identity	Description
trim3a	7.147e-7	39.74	tripartite motif-containing protein 3 [Source:NCBI...	[more]
trim3a	7.206e-7	39.74	tripartite motif-containing protein 3 [Source:NCBI...	[more]
trim2a	1.991e-6	37.18	tripartite motif containing 2 [Source:NCBI gene;Ac...	[more]
trim2a	1.991e-6	37.18	tripartite motif containing 2 [Source:NCBI gene;Ac...	[more]
trim2a	1.991e-6	37.18	tripartite motif containing 2 [Source:NCBI gene;Ac...	[more]

BLAST of RING-type domain-containing protein vs. Planmine SMEST
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST)
Total hits: 5


Match Name	E-value	Identity	Description
SMESG000069649.1	0.000e+0	98.05	SMESG000069649.1	[more]
SMESG000069646.1	2.347e-60	36.88	SMESG000069646.1	[more]
SMESG000020467.1	3.530e-21	25.68	SMESG000020467.1	[more]
SMESG000064098.1	1.204e-19	28.51	SMESG000064098.1	[more]
SMESG000064098.1	1.257e-19	28.51	SMESG000064098.1	[more]

Analyses

This transcript is derived from or has results from the following analyses


Analysis Name	Date Performed
Embryonic Stages	2016-07-25
Schmidtea mediterranea smed_20140614 BLASTX Human e!99	2016-08-08
Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99	2016-08-08
Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL	2020-05-01
Schmidtea mediterranea Sexual smed_20140614 transcriptome	2016-07-25
Schmidtea mediteranean smed_20140614 Interproscan	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST	2020-05-08

Sequences

The following sequences are available for this feature:

transcript sequence
protein sequence

transcript sequence

>SMED30011825 ID=SMED30011825|Name=RING-type domain-containing protein|organism=Schmidtea mediterranea sexual|type=transcript|length=1501bp
GGACATTTTGTCTCAATTCAATTTTTAAGAAATTTTTTTTCATCGATTTT
CAGTTTATTGTCTTTGCTTATTAGAGAAAACGATAATTATGGTAATTAAT
TATCATGATAAATATGTGGCATATCATGCATACATTCAAAATGCTGTGTG
CATCCAGTCAAATACAGTAGCCTTATGACGTATACATTACCTCGATATTG
ATGTTAATATTTTATTAGTTTTGAATACCGAAAATTCTCTACAAATTATT
TATGGAGGATTTAACAAAATCAGAAATAATAGACAAGTTGGGAGAAATCC
TCGAATGTTCTATTCATCACGGAATAATGACCAATCCCAAAATGCTTTCA
TGCCAGCATACATTTTGTTATAAATGTATAAAAGACTATTTTAAAATAAT
TCAACCTCTTTTAATTTGCCCGATATGTAGAAGAGAAGAAAATGTTGATG
GGGTGGAAAAGTTACCTCCGTCGTATATACACAATAAATTGATGGAGATA
TTAAAATTAAAAACAAAATCCGAATCAAATGCTGACGATAGCGACAGCGA
AAATGATTCAGAGTGGAAAATTGAAACCGTACAACAAAATATGGTTGACA
ATTCTCATTATCAACAGATTTATCCAACTGAATTTGAAAATGTTCGTAAG
ATTTTATCACAGAAAAATGAAACTGATTTTTCATTGGTTACTGCAAATAA
CCTAAATTCCGAATCCAGTCAAATTGTATTAGTTGATTCTTGTACCAATC
AAATTACTGTTTATTCCACTTCCGGCGAATCGACTTTCTCCATTTACATT
GACAATGAAATTGTGATTCCTCGGTACATTCGAGTTATTCAAAACAGTTT
ATATTTAACCGGTAACAGAAAAGATAAAGGTCTAACAGTTTCTGTTTTTA
TTCAAAGCGATTTTCATGGAAATGTCATTAAAAGATCAGAATTTTATGTC
ACCGACTCTTCCGCATTTTTAGGATTCGACTTCAACGAAACTAAGAATTT
ATTCTACGTCTGCATGCCGGAAAACAAAACGATTCAATTATTTGATAGAT
TTCTTGAAGATTATAATCATTGTTTCGACCTCAAAGAAAACTCACCGGAA
TTTATTGCTTTCAATAAACAAGAAAAACAGCTCTATATTTCCTGTCCTCT
TAATCGGCGCATTTTGATATATAATTCTGAAACTTATAAAACGATTTCAA
CTGACGAAATTGTGCCGAAAATGATTTTTGTCACCGATGATGAGAAGGTC
TTATTTCTCGATGAGAAAGCAAACAGAATTATTTGGATTAAAAGGATAAA
TGATCATTTGTTACAACAGCAGCTGGATCTGCCGTATTTACGAAGAGATT
TACACATTAAAACATTTTATGCTTTGTCTTTATCAATGATTTTTATTGCT
ACCAATGATCAGATTTTTCTCTATCAATTAGATCAGAATTTATCAAGTTC
TAATAGAGTTTCTCCGTTTTGTAATTTGTCGTAATGTTAAACTTTGATTT
G

protein sequence of SMED30011825-orf-1

>SMED30011825-orf-1 ID=SMED30011825-orf-1|Name=SMED30011825-orf-1|organism=Schmidtea mediterranea sexual|type=polypeptide|length=411bp
MEDLTKSEIIDKLGEILECSIHHGIMTNPKMLSCQHTFCYKCIKDYFKII
QPLLICPICRREENVDGVEKLPPSYIHNKLMEILKLKTKSESNADDSDSE
NDSEWKIETVQQNMVDNSHYQQIYPTEFENVRKILSQKNETDFSLVTANN
LNSESSQIVLVDSCTNQITVYSTSGESTFSIYIDNEIVIPRYIRVIQNSL
YLTGNRKDKGLTVSVFIQSDFHGNVIKRSEFYVTDSSAFLGFDFNETKNL
FYVCMPENKTIQLFDRFLEDYNHCFDLKENSPEFIAFNKQEKQLYISCPL
NRRILIYNSETYKTISTDEIVPKMIFVTDDEKVLFLDEKANRIIWIKRIN
DHLLQQQLDLPYLRRDLHIKTFYALSLSMIFIATNDQIFLYQLDQNLSSS
NRVSPFCNLS*

Annotated Terms

The following terms have been associated with this transcript:

Vocabulary: **Planarian Anatomy**
Term	Definition
PLANA:0000099	neuron
PLANA:0000418	head

Vocabulary: **INTERPRO**
Term	Definition
IPR013083	Znf_RING/FYVE/PHD
IPR011042	6-blade_b-propeller_TolB-like
IPR017907	Znf_RING_CS
IPR001841	Znf_RING

Vocabulary: **molecular function**
Term	Definition
GO:0008270	zinc ion binding
GO:0005515	protein binding
GO:0004842	ubiquitin-protein transferase activity
GO:0016740	transferase activity
GO:0046872	metal ion binding

Vocabulary: **cellular component**
Term	Definition
GO:0005622	intracellular
GO:0005737	cytoplasm

Vocabulary: **biological process**
Term	Definition
GO:0016567	protein ubiquitination
GO:0043523	regulation of neuron apoptotic process

InterPro

Analysis Name: Schmidtea mediteranean smed_20140614 Interproscan
Date Performed: 2020-05-01


IPR Term	IPR Description	Source	Source Term	Source Description	Alignment
IPR011042	Six-bladed beta-propeller, TolB-like	GENE3D	G3DSA:2.120.10.30		coord: 151..359 e-value: 1.5E-7 score: 32.8
IPR013083	Zinc finger, RING/FYVE/PHD-type	GENE3D	G3DSA:3.30.40.10		coord: 3..120 e-value: 1.2E-14 score: 56.1
None	No IPR available	PANTHER	PTHR25464:SF2	E3 UBIQUITIN-PROTEIN LIGASE RNF152	coord: 13..148
None	No IPR available	PANTHER	PTHR25464	FAMILY NOT NAMED	coord: 13..148
None	No IPR available	CDD	cd16449	RING-HC	coord: 19..59 e-value: 1.75302E-9 score: 50.9289
None	No IPR available	SUPERFAMILY	SSF57850	RING/U-box	coord: 11..85
None	No IPR available	SUPERFAMILY	SSF75011	3-carboxy-cis,cis-mucoante lactonizing enzyme	coord: 152..352
IPR017907	Zinc finger, RING-type, conserved site	PROSITE	PS00518	ZF_RING_1	coord: 34..43
IPR001841	Zinc finger, RING-type	PROSITE	PS50089	ZF_RING_2	coord: 19..60 score: 10.571

Main menu

RING-type domain-containing protein

Zeng et. al., 2018

▻ Overview

▻ Neoblast Population

▻ Sub-lethal Irradiated Surviving X1 and X2 Cell Population

Overview

Single cell RNA-seq of pluripotent neoblasts and its early progenies

Explore this single cell expression dataset with our NB Cluster Shiny App

Neoblast Population

Sub-lethal Irradiated Surviving X1 and X2 Cell Population

Davies et. al., 2017

PAGE et. al., 2020

has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGE

PAGE Curations: 2

Owlery

blazegraph-runner