Homeobox protein DTH-1

Overview


Name	Homeobox protein DTH-1
Smed ID	SMED30011793
Length (bp)	1926

Neoblast Clusters

▻ Sub-lethal Irradiated Surviving X1 and X2 Cell Population

Overview

Single cell RNA-seq of pluripotent neoblasts and its early progenies

We isolated X1 neoblasts cells enriched in high piwi-1 expression (Neoblast Population), and profiled ∼7,614 individual cells via scRNA-seq. Unsupervised analyses uncovered 12 distinct classes from 7,088 high-quality cells. We designated these classes Nb1 to Nb12 and ordered them based on high (Nb1) to low (Nb12) piwi-1 expression levels. We further defined groups of genes that best classified the cells parsed into 12 distinct cell clusters to generate a scaled expression heat map of discriminative gene sets for each cluster. Expression of each cluster’s gene signatures was validated using multiplex fluorescence in situ hybridization (FISH) co-stained with piwi-1 and largely confirmed the cell clusters revealed by scRNA-seq.

We also tested sub-lethal irradiation exposure. To profile rare pluripotent stem cells (PSCs) and avoid interference from immediate progenitor cells, we determined a time point after sub-lethal irradiation (7 DPI) with minimal piwi-1+ cells, followed by isolation and single-cell RNA-seq of 1,200 individual cells derived from X1 (Piwi-1 high) and X2 (Piwi-1 low) cell populations (Sub-lethal Irradiated Surviving X1 and X2 Cell Population)

Explore this single cell expression dataset with our NB Cluster Shiny App

Neoblast Population

t-SNE plot shows two-dimensional representation of global gene expression relationships among all neoblasts (n = 7,088 after filter). Cluster identity was assigned based on the top 10 marker genes of each cluster (Table S2), followed by inspection of RNA in situ hybridization patterns. Neoblast groups, Nb.

Expression of Homeobox protein DTH-1 (SMED30011793) t-SNE clustered cells

Violin plots show distribution of expression levels for Homeobox protein DTH-1 (SMED30011793) in cells (dots) of each of the 12 neoblast clusters.

Sub-lethal Irradiated Surviving X1 and X2 Cell Population

t-SNE plot of surviving X1 and X2 cells (n = 1,039 after QC filter) after sub-lethal irradiation. Colors indicate unbiased cell classification via graph-based clustering. SL, sub-lethal irradiated cell groups.

Expression of Homeobox protein DTH-1 (SMED30011793) in the t-SNE clustered sub-lethally irradiated X1 and X2 cells.

Violin plots show distribution of expression levels for Homeobox protein DTH-1 (SMED30011793) in cells (dots) of each of the 10 clusters of sub-leathally irradiated X1 and X2 cells.

Embryonic Expression

Davies et. al., 2017

Hover the mouse over a column in the graph to view average RPKM values per sample.
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Embryonic Stages: Y: yolk. S2-S8: Stages 2-8. C4: asexual adult. SX: virgin, sexually mature adult.
For further information about sample preparation and analysis for the single animal RNA-Seq experiment, please refer to the Materials and Methods

Anatomical Expression

PAGE et. al., 2020

SMED30011793

has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGE

PAGE Curations: 12

Expressed In	Reference Transcript	Gene Models	Published Transcript	Transcriptome	Publication
gut	SMED30011793	h1SMcG0009317	Contig5669	GPL15192	PMID:23079596 Forsthoefel et al., 2012
intestinal phagocyte	SMED30011793	h1SMcG0009317	Contig5669	GPL15192	PMID:23079596 Forsthoefel et al., 2012
gut	SMED30011793	h1SMcG0021644	Contig5669	GPL15192	PMID:23079596 Forsthoefel et al., 2012
intestinal phagocyte	SMED30011793	h1SMcG0021644	Contig5669	GPL15192	PMID:23079596 Forsthoefel et al., 2012
gamma neoblast	SMED30011793	h1SMcG0009317	SMED30011793	smed_20140614	PMID:29906446 Zeng et al., 2018
gut	SMED30011793	h1SMcG0009317	dd_Smed_v4_2716_0_1	dd_Smed_v4	PMID:29674431 Fincher et al., 2018
cephalic ganglia	SMED30011793	h1SMcG0009317	dd_Smed_v4_2716_0_1	dd_Smed_v4	PMID:29674431 Fincher et al., 2018
neoblast	SMED30011793	h1SMcG0009317	dd_Smed_v4_2716_0_1	dd_Smed_v4	PMID:29674431 Fincher et al., 2018
tail region	SMED30011793	h1SMcG0009317	dd_Smed_v6_2716_0_1	dd_Smed_v6	PMID:28171748 Stückemann et al., 2017
gamma neoblast	SMED30011793	h1SMcG0009317	SMED30011793	smed_20140614	PMID:25017721 van Wolfswinkel et al., 2014
gut	SMED30011793	h1SMcG0009317	SMED30011793	smed_20140614	PMID:26457503 Tu et al., 2015
parenchyma	SMED30011793	h1SMcG0009317	SMED30011793	smed_20140614	PMID:26457503 Tu et al., 2015

Note: Hover over icons to view figure legend

Homology

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BLAST of Homeobox protein DTH-1 vs. Ensembl Human
Match: NKX2-2 (NK2 homeobox 2 [Source:HGNC Symbol;Acc:HGNC:7835])

HSP 1 Score: 125.561 bits (314), Expect = 1.155e-31
Identity = 58/80 (72.50%), Postives = 66/80 (82.50%), Query Frame = 3

Query: 1293 VGKKRKRRVLFSKKQILELERHFRQKKYLSAPEREHLANLIGLSPTQVKIWFQNHRYKMKRAHHEKSLEMGNLAVNRRIS 1532
             GKKRKRRVLFSK Q  ELER FRQ++YLSAPEREHLA+LI L+PTQVKIWFQNHRYKMKRA  EK +E+  L   RR++
Sbjct:  125 AGKKRKRRVLFSKAQTYELERRFRQQRYLSAPEREHLASLIRLTPTQVKIWFQNHRYKMKRARAEKGMEVTPLPSPRRVA 204

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BLAST of Homeobox protein DTH-1 vs. Ensembl Human
Match: NKX2-8 (NK2 homeobox 8 [Source:HGNC Symbol;Acc:HGNC:16364])

HSP 1 Score: 110.153 bits (274), Expect = 1.645e-26
Identity = 50/77 (64.94%), Postives = 62/77 (80.52%), Query Frame = 3

Query: 1299 KKRKRRVLFSKKQILELERHFRQKKYLSAPEREHLANLIGLSPTQVKIWFQNHRYKMKRAHHEKSLEMGNLAVNRRI 1529
            K++KRRVLFSK Q LELER FRQ++YLSAPERE LA+L+ L+PTQVKIWFQNHRYK+KRA    + E  +LA +  +
Sbjct:   83 KRKKRRVLFSKAQTLELERRFRQQRYLSAPEREQLASLLRLTPTQVKIWFQNHRYKLKRARAPGAAESPDLAASAEL 159

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BLAST of Homeobox protein DTH-1 vs. Ensembl Human
Match: NKX2-4 (NK2 homeobox 4 [Source:HGNC Symbol;Acc:HGNC:7837])

HSP 1 Score: 107.842 bits (268), Expect = 8.590e-25
Identity = 47/66 (71.21%), Postives = 58/66 (87.88%), Query Frame = 3

Query: 1302 KRKRRVLFSKKQILELERHFRQKKYLSAPEREHLANLIGLSPTQVKIWFQNHRYKMKRAHHEKSLE 1499
            +RKRRVLFS+ Q+ ELER F+Q+KYLSAPEREHLA++I L+PTQVKIWFQNHRYKMKR   +K+ +
Sbjct:  189 RRKRRVLFSQAQVYELERRFKQQKYLSAPEREHLASMIHLTPTQVKIWFQNHRYKMKRQAKDKAAQ 254

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BLAST of Homeobox protein DTH-1 vs. Ensembl Human
Match: NKX2-1 (NK2 homeobox 1 [Source:HGNC Symbol;Acc:HGNC:11825])

HSP 1 Score: 107.842 bits (268), Expect = 9.644e-25
Identity = 47/64 (73.44%), Postives = 57/64 (89.06%), Query Frame = 3

Query: 1302 KRKRRVLFSKKQILELERHFRQKKYLSAPEREHLANLIGLSPTQVKIWFQNHRYKMKRAHHEKS 1493
            +RKRRVLFS+ Q+ ELER F+Q+KYLSAPEREHLA++I L+PTQVKIWFQNHRYKMKR   +K+
Sbjct:  161 RRKRRVLFSQAQVYELERRFKQQKYLSAPEREHLASMIHLTPTQVKIWFQNHRYKMKRQAKDKA 224

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Query: 1302 KRKRRVLFSKKQILELERHFRQKKYLSAPEREHLANLIGLSPTQVKIWFQNHRYKMKRAHHEKS 1493
            +RKRRVLFS+ Q+ ELER F+Q+KYLSAPEREHLA++I L+PTQVKIWFQNHRYKMKR   +K+
Sbjct:  161 RRKRRVLFSQAQVYELERRFKQQKYLSAPEREHLASMIHLTPTQVKIWFQNHRYKMKRQAKDKA 224

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BLAST of Homeobox protein DTH-1 vs. Ensembl Celegans
Match: ceh-24 (Homeobox protein ceh-24 [Source:UniProtKB/Swiss-Prot;Acc:Q9NLC2])

HSP 1 Score: 103.219 bits (256), Expect = 4.667e-24
Identity = 46/68 (67.65%), Postives = 56/68 (82.35%), Query Frame = 3

Query: 1293 VGKKRKRRVLFSKKQILELERHFRQKKYLSAPEREHLANLIGLSPTQVKIWFQNHRYKMKRAHHEKSL 1496
            + ++RKRRVLFS+ Q+ ELER F+Q KYL+APERE LAN I L+PTQVKIWFQNHRYK KR   EK++
Sbjct:  147 MSQRRKRRVLFSQAQVYELERRFKQAKYLTAPEREQLANSIRLTPTQVKIWFQNHRYKCKRQEKEKAM 214

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BLAST of Homeobox protein DTH-1 vs. Ensembl Celegans
Match: ceh-22 (Homeobox protein ceh-22 [Source:UniProtKB/Swiss-Prot;Acc:P41936])

HSP 1 Score: 92.4337 bits (228), Expect = 4.583e-21
Identity = 42/67 (62.69%), Postives = 49/67 (73.13%), Query Frame = 3

Query: 1317 VLFSKKQILELERHFRQKKYLSAPEREHLANLIGLSPTQVKIWFQNHRYKMKRAHHEKSLEMGNLAV 1517
            VLF+K Q  ELER FR +KYLSAPERE LA  I L+PTQVKIWFQNHRYK K++H +K +    L  
Sbjct:   63 VLFTKAQTYELERRFRSQKYLSAPEREALAMQIRLTPTQVKIWFQNHRYKTKKSHTDKPINAALLTT 129

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BLAST of Homeobox protein DTH-1 vs. Ensembl Celegans
Match: ceh-22 (Homeobox protein ceh-22 [Source:UniProtKB/Swiss-Prot;Acc:P41936])

HSP 1 Score: 93.2041 bits (230), Expect = 6.961e-21
Identity = 42/67 (62.69%), Postives = 49/67 (73.13%), Query Frame = 3

Query: 1317 VLFSKKQILELERHFRQKKYLSAPEREHLANLIGLSPTQVKIWFQNHRYKMKRAHHEKSLEMGNLAV 1517
            VLF+K Q  ELER FR +KYLSAPERE LA  I L+PTQVKIWFQNHRYK K++H +K +    L  
Sbjct:  108 VLFTKAQTYELERRFRSQKYLSAPEREALAMQIRLTPTQVKIWFQNHRYKTKKSHTDKPINAALLTT 174

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BLAST of Homeobox protein DTH-1 vs. Ensembl Celegans
Match: ceh-22 (Homeobox protein ceh-22 [Source:UniProtKB/Swiss-Prot;Acc:P41936])

HSP 1 Score: 92.8189 bits (229), Expect = 1.105e-20
Identity = 42/67 (62.69%), Postives = 49/67 (73.13%), Query Frame = 3

Query: 1317 VLFSKKQILELERHFRQKKYLSAPEREHLANLIGLSPTQVKIWFQNHRYKMKRAHHEKSLEMGNLAV 1517
            VLF+K Q  ELER FR +KYLSAPERE LA  I L+PTQVKIWFQNHRYK K++H +K +    L  
Sbjct:  131 VLFTKAQTYELERRFRSQKYLSAPEREALAMQIRLTPTQVKIWFQNHRYKTKKSHTDKPINAALLTT 197

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BLAST of Homeobox protein DTH-1 vs. Ensembl Celegans
Match: ceh-22 (Homeobox protein ceh-22 [Source:UniProtKB/Swiss-Prot;Acc:P41936])

HSP 1 Score: 92.8189 bits (229), Expect = 3.099e-20
Identity = 42/67 (62.69%), Postives = 49/67 (73.13%), Query Frame = 3

Query: 1317 VLFSKKQILELERHFRQKKYLSAPEREHLANLIGLSPTQVKIWFQNHRYKMKRAHHEKSLEMGNLAV 1517
            VLF+K Q  ELER FR +KYLSAPERE LA  I L+PTQVKIWFQNHRYK K++H +K +    L  
Sbjct:  194 VLFTKAQTYELERRFRSQKYLSAPEREALAMQIRLTPTQVKIWFQNHRYKTKKSHTDKPINAALLTT 260

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BLAST of Homeobox protein DTH-1 vs. Ensembl Fly
Match: scro (gene:FBgn0028993 transcript:FBtr0339923)

HSP 1 Score: 110.153 bits (274), Expect = 2.571e-26
Identity = 46/68 (67.65%), Postives = 59/68 (86.76%), Query Frame = 3

Query: 1293 VGKKRKRRVLFSKKQILELERHFRQKKYLSAPEREHLANLIGLSPTQVKIWFQNHRYKMKRAHHEKSL 1496
            + ++RKRRVLF++ Q+ ELER F+Q++YLSAPEREHLA+LI L+PTQVKIWFQNHRYK KR   EK++
Sbjct:   89 LAQRRKRRVLFTQAQVYELERRFKQQRYLSAPEREHLASLIHLTPTQVKIWFQNHRYKCKRQAKEKAM 156

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BLAST of Homeobox protein DTH-1 vs. Ensembl Fly
Match: vnd (gene:FBgn0261930 transcript:FBtr0110929)

HSP 1 Score: 113.62 bits (283), Expect = 4.437e-26
Identity = 52/67 (77.61%), Postives = 58/67 (86.57%), Query Frame = 3

Query: 1299 KKRKRRVLFSKKQILELERHFRQKKYLSAPEREHLANLIGLSPTQVKIWFQNHRYKMKRAHHEKSLE 1499
            KKRKRRVLF+K Q  ELER FRQ++YLSAPEREHLA+LI L+PTQVKIWFQNHRYK KRA +EK  E
Sbjct:  398 KKRKRRVLFTKAQTYELERRFRQQRYLSAPEREHLASLIRLTPTQVKIWFQNHRYKTKRAQNEKGYE 464

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BLAST of Homeobox protein DTH-1 vs. Ensembl Fly
Match: vnd (gene:FBgn0261930 transcript:FBtr0070110)

HSP 1 Score: 113.62 bits (283), Expect = 6.839e-26
Identity = 52/67 (77.61%), Postives = 58/67 (86.57%), Query Frame = 3

Query: 1299 KKRKRRVLFSKKQILELERHFRQKKYLSAPEREHLANLIGLSPTQVKIWFQNHRYKMKRAHHEKSLE 1499
            KKRKRRVLF+K Q  ELER FRQ++YLSAPEREHLA+LI L+PTQVKIWFQNHRYK KRA +EK  E
Sbjct:  544 KKRKRRVLFTKAQTYELERRFRQQRYLSAPEREHLASLIRLTPTQVKIWFQNHRYKTKRAQNEKGYE 610

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BLAST of Homeobox protein DTH-1 vs. Ensembl Fly
Match: scro (gene:FBgn0028993 transcript:FBtr0113751)

HSP 1 Score: 110.538 bits (275), Expect = 2.061e-25
Identity = 46/68 (67.65%), Postives = 59/68 (86.76%), Query Frame = 3

Query: 1293 VGKKRKRRVLFSKKQILELERHFRQKKYLSAPEREHLANLIGLSPTQVKIWFQNHRYKMKRAHHEKSL 1496
            + ++RKRRVLF++ Q+ ELER F+Q++YLSAPEREHLA+LI L+PTQVKIWFQNHRYK KR   EK++
Sbjct:  250 LAQRRKRRVLFTQAQVYELERRFKQQRYLSAPEREHLASLIHLTPTQVKIWFQNHRYKCKRQAKEKAM 317

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BLAST of Homeobox protein DTH-1 vs. Ensembl Fly
Match: tin (gene:FBgn0004110 transcript:FBtr0084086)

HSP 1 Score: 82.0333 bits (201), Expect = 3.091e-16
Identity = 39/59 (66.10%), Postives = 44/59 (74.58%), Query Frame = 3

Query: 1302 KRKRRVLFSKKQILELERHFRQKKYLSAPEREHLANLIGLSPTQVKIWFQNHRYKMKRA 1478
            KRK RVLFS+ Q+LELE  FR KKYL+  ERE +A  + LS TQVKIWFQN RYK KR 
Sbjct:  301 KRKPRVLFSQAQVLELECRFRLKKYLTGAEREIIAQKLNLSATQVKIWFQNRRYKSKRG 359

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BLAST of Homeobox protein DTH-1 vs. Ensembl Zebrafish
Match: nkx2.2a (NK2 homeobox 2a [Source:NCBI gene;Acc:30697])

HSP 1 Score: 127.872 bits (320), Expect = 1.298e-32
Identity = 58/79 (73.42%), Postives = 67/79 (84.81%), Query Frame = 3

Query: 1296 GKKRKRRVLFSKKQILELERHFRQKKYLSAPEREHLANLIGLSPTQVKIWFQNHRYKMKRAHHEKSLEMGNLAVNRRIS 1532
            GKKRKRRVLFSK Q  ELER FRQ++YLSAPEREHLA+LI L+PTQVKIWFQNHRYKMKRA  EK +E+ +L   RR++
Sbjct:  123 GKKRKRRVLFSKAQTYELERRFRQQRYLSAPEREHLASLIRLTPTQVKIWFQNHRYKMKRARAEKGMEVTHLPSPRRVA 201

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Query: 1296 GKKRKRRVLFSKKQILELERHFRQKKYLSAPEREHLANLIGLSPTQVKIWFQNHRYKMKRAHHEKSLEMGNLAVNRRIS 1532
            GKKRKRRVLFSK Q  ELER FRQ++YLSAPEREHLA+LI L+PTQVKIWFQNHRYKMKRA  EK +E+ +L   RR++
Sbjct:  123 GKKRKRRVLFSKAQTYELERRFRQQRYLSAPEREHLASLIRLTPTQVKIWFQNHRYKMKRARAEKGMEVTHLPSPRRVA 201

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BLAST of Homeobox protein DTH-1 vs. Ensembl Zebrafish
Match: nkx2.2a (NK2 homeobox 2a [Source:NCBI gene;Acc:30697])

HSP 1 Score: 127.487 bits (319), Expect = 1.574e-32
Identity = 58/79 (73.42%), Postives = 67/79 (84.81%), Query Frame = 3

Query: 1296 GKKRKRRVLFSKKQILELERHFRQKKYLSAPEREHLANLIGLSPTQVKIWFQNHRYKMKRAHHEKSLEMGNLAVNRRIS 1532
            GKKRKRRVLFSK Q  ELER FRQ++YLSAPEREHLA+LI L+PTQVKIWFQNHRYKMKRA  EK +E+ +L   RR++
Sbjct:  127 GKKRKRRVLFSKAQTYELERRFRQQRYLSAPEREHLASLIRLTPTQVKIWFQNHRYKMKRARAEKGMEVTHLPSPRRVA 205

[Close]

Query: 1296 GKKRKRRVLFSKKQILELERHFRQKKYLSAPEREHLANLIGLSPTQVKIWFQNHRYKMKRAHHEKSLEMGNLAVNRRIS 1532
            GKKRKRRVLFSK Q  ELER FRQ++YLSAPEREHLA+LI L+PTQVKIWFQNHRYKMKRA  EK +E+ +L   RR++
Sbjct:  127 GKKRKRRVLFSKAQTYELERRFRQQRYLSAPEREHLASLIRLTPTQVKIWFQNHRYKMKRARAEKGMEVTHLPSPRRVA 205

[Close]

Query: 1296 GKKRKRRVLFSKKQILELERHFRQKKYLSAPEREHLANLIGLSPTQVKIWFQNHRYKMKRAHHEKSLEMGNLAVNRRIS 1532
            GKKRKRRVLFSK Q  ELER FRQ++YLSAPEREHLA+LI L+PTQVKIWFQNHRYKMKRA  EK +E+ +L   RR++
Sbjct:  127 GKKRKRRVLFSKAQTYELERRFRQQRYLSAPEREHLASLIRLTPTQVKIWFQNHRYKMKRARAEKGMEVTHLPSPRRVA 205

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BLAST of Homeobox protein DTH-1 vs. Ensembl Xenopus
Match: NKX2-2 (NK2 homeobox 2 [Source:NCBI gene;Acc:100038077])

HSP 1 Score: 126.716 bits (317), Expect = 3.955e-32
Identity = 58/79 (73.42%), Postives = 66/79 (83.54%), Query Frame = 3

Query: 1296 GKKRKRRVLFSKKQILELERHFRQKKYLSAPEREHLANLIGLSPTQVKIWFQNHRYKMKRAHHEKSLEMGNLAVNRRIS 1532
            GKKRKRRVLFSK Q  ELER FRQ++YLSAPEREHLA+LI L+PTQVKIWFQNHRYKMKRA  EK +E+  L   RR++
Sbjct:  125 GKKRKRRVLFSKAQTYELERRFRQQRYLSAPEREHLASLIRLTPTQVKIWFQNHRYKMKRARAEKGMEVTPLPSPRRVA 203

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BLAST of Homeobox protein DTH-1 vs. Ensembl Xenopus
Match: fam221a (family with sequence similarity 221 member A [Source:Xenbase;Acc:XB-GENE-1000335])

HSP 1 Score: 109.768 bits (273), Expect = 1.768e-25
Identity = 47/66 (71.21%), Postives = 58/66 (87.88%), Query Frame = 3

Query: 1302 KRKRRVLFSKKQILELERHFRQKKYLSAPEREHLANLIGLSPTQVKIWFQNHRYKMKRAHHEKSLE 1499
            +RKRRVLFS+ Q+ ELER F+Q+KYLSAPEREHLA++I L+PTQVKIWFQNHRYKMKR   +K+ +
Sbjct:  162 RRKRRVLFSQAQVYELERRFKQQKYLSAPEREHLASMIHLTPTQVKIWFQNHRYKMKRQAKDKAAQ 227

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BLAST of Homeobox protein DTH-1 vs. Ensembl Xenopus
Match: trpc3 (transient receptor potential cation channel, subfamily C, member 3 [Source:Xenbase;Acc:XB-GENE-1014039])

HSP 1 Score: 108.612 bits (270), Expect = 3.509e-25
Identity = 47/63 (74.60%), Postives = 56/63 (88.89%), Query Frame = 3

Query: 1302 KRKRRVLFSKKQILELERHFRQKKYLSAPEREHLANLIGLSPTQVKIWFQNHRYKMKRAHHEK 1490
            +RKRRVLFS+ Q+ ELER F+Q+KYLSAPEREHLA++I L+PTQVKIWFQNHRYKMKR   +K
Sbjct:  160 RRKRRVLFSQAQVYELERRFKQQKYLSAPEREHLASMIHLTPTQVKIWFQNHRYKMKRQAKDK 222

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BLAST of Homeobox protein DTH-1 vs. Ensembl Xenopus
Match: NKX2-3 (NK2 homeobox 3 [Source:NCBI gene;Acc:100486189])

HSP 1 Score: 104.375 bits (259), Expect = 8.119e-24
Identity = 47/68 (69.12%), Postives = 56/68 (82.35%), Query Frame = 3

Query: 1302 KRKRRVLFSKKQILELERHFRQKKYLSAPEREHLANLIGLSPTQVKIWFQNHRYKMKRAHHEKSLEMG 1505
            +RK RVLFS+ Q+ ELER F+Q++YLSAPEREHLAN + L+ TQVKIWFQN RYK KR   +KSLEMG
Sbjct:  146 RRKPRVLFSQAQVFELERRFKQQRYLSAPEREHLANSLKLTSTQVKIWFQNRRYKCKRQRQDKSLEMG 213

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BLAST of Homeobox protein DTH-1 vs. Ensembl Xenopus
Match: mtm1 (myotubularin 1 [Source:Xenbase;Acc:XB-GENE-1002030])

HSP 1 Score: 99.3673 bits (246), Expect = 1.045e-22
Identity = 45/78 (57.69%), Postives = 60/78 (76.92%), Query Frame = 3

Query: 1299 KKRKRRVLFSKKQILELERHFRQKKYLSAPEREHLANLIGLSPTQVKIWFQNHRYKMKRAHHEKSLEMGNLAVNRRIS 1532
            ++RK RVLFS+ Q+ ELER F+Q++YLSAPERE LA  + L+ TQVKIWFQN RYK KR   ++SLE+G+    RR++
Sbjct:   93 QRRKPRVLFSQMQVFELERRFKQQRYLSAPEREQLALALKLTSTQVKIWFQNRRYKCKRQKQDRSLELGHPIPPRRVA 170

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BLAST of Homeobox protein DTH-1 vs. Ensembl Mouse
Match: Nkx2-2 (NK2 homeobox 2 [Source:MGI Symbol;Acc:MGI:97347])

HSP 1 Score: 125.946 bits (315), Expect = 6.214e-32
Identity = 58/80 (72.50%), Postives = 66/80 (82.50%), Query Frame = 3

Query: 1293 VGKKRKRRVLFSKKQILELERHFRQKKYLSAPEREHLANLIGLSPTQVKIWFQNHRYKMKRAHHEKSLEMGNLAVNRRIS 1532
             GKKRKRRVLFSK Q  ELER FRQ++YLSAPEREHLA+LI L+PTQVKIWFQNHRYKMKRA  EK +E+  L   RR++
Sbjct:  125 AGKKRKRRVLFSKAQTYELERRFRQQRYLSAPEREHLASLIRLTPTQVKIWFQNHRYKMKRARAEKGMEVTPLPSPRRVA 204

[Close]

BLAST of Homeobox protein DTH-1 vs. Ensembl Mouse
Match: Nkx2-2 (NK2 homeobox 2 [Source:MGI Symbol;Acc:MGI:97347])

HSP 1 Score: 118.627 bits (296), Expect = 1.379e-29
Identity = 57/79 (72.15%), Postives = 64/79 (81.01%), Query Frame = 3

Query: 1293 VGKKRKRRVLFSKKQILELERHFRQKKYLSAPEREHLANLIGLSPTQVKIWFQNHRYKMKRAHHEKSLEMGNLAVNRRI 1529
             GKKRKRRVLFSK Q  ELER FRQ++YLSAPEREHLA+LI L+PTQVKIWFQNHRYKMKRA  EK+ +      NRR+
Sbjct:  125 AGKKRKRRVLFSKAQTYELERRFRQQRYLSAPEREHLASLIRLTPTQVKIWFQNHRYKMKRARAEKAFQ------NRRM 197

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BLAST of Homeobox protein DTH-1 vs. Ensembl Mouse
Match: Nkx2-9 (NK2 homeobox 9 [Source:MGI Symbol;Acc:MGI:1270158])

HSP 1 Score: 106.686 bits (265), Expect = 1.411e-25
Identity = 49/74 (66.22%), Postives = 58/74 (78.38%), Query Frame = 3

Query: 1299 KKRKRRVLFSKKQILELERHFRQKKYLSAPEREHLANLIGLSPTQVKIWFQNHRYKMKRAHHEKSLEMGNLAVN 1520
            K+RKRRVLFSK Q LELER FRQ++YLSAPERE LA L+ L+PTQVKIWFQNHRYK+KR       E  ++A +
Sbjct:   80 KRRKRRVLFSKAQTLELERRFRQQRYLSAPEREQLARLLRLTPTQVKIWFQNHRYKLKRGRAPGITEPSDMAAS 153

[Close]

BLAST of Homeobox protein DTH-1 vs. Ensembl Mouse
Match: Nkx2-4 (NK2 homeobox 4 [Source:MGI Symbol;Acc:MGI:97349])

HSP 1 Score: 109.383 bits (272), Expect = 1.892e-25
Identity = 47/66 (71.21%), Postives = 58/66 (87.88%), Query Frame = 3

Query: 1302 KRKRRVLFSKKQILELERHFRQKKYLSAPEREHLANLIGLSPTQVKIWFQNHRYKMKRAHHEKSLE 1499
            +RKRRVLFS+ Q+ ELER F+Q+KYLSAPEREHLA++I L+PTQVKIWFQNHRYKMKR   +K+ +
Sbjct:  188 RRKRRVLFSQAQVYELERRFKQQKYLSAPEREHLASMIHLTPTQVKIWFQNHRYKMKRQAKDKAAQ 253

[Close]

BLAST of Homeobox protein DTH-1 vs. Ensembl Mouse
Match: Nkx2-1 (NK2 homeobox 1 [Source:MGI Symbol;Acc:MGI:108067])

HSP 1 Score: 107.457 bits (267), Expect = 9.583e-25
Identity = 47/64 (73.44%), Postives = 57/64 (89.06%), Query Frame = 3

Query: 1302 KRKRRVLFSKKQILELERHFRQKKYLSAPEREHLANLIGLSPTQVKIWFQNHRYKMKRAHHEKS 1493
            +RKRRVLFS+ Q+ ELER F+Q+KYLSAPEREHLA++I L+PTQVKIWFQNHRYKMKR   +K+
Sbjct:  161 RRKRRVLFSQAQVYELERRFKQQKYLSAPEREHLASMIHLTPTQVKIWFQNHRYKMKRQAKDKA 224

[Close]

BLAST of Homeobox protein DTH-1 vs. UniProt/SwissProt
Match: sp|Q00400|DTH1_GIRTI (Homeobox protein DTH-1 OS=Girardia tigrina OX=6162 GN=DTH-1 PE=2 SV=2)

HSP 1 Score: 623.624 bits (1607), Expect = 0.000e+0
Identity = 383/542 (70.66%), Postives = 445/542 (82.10%), Query Frame = 3

Query:  159 MSSNGDCVKYDSNFDREGYSTDTSTDCPIQTDDSLHEIQTSSLPDSFQLFPQNTKAHINELHETFSAANSITQHLQVXXXXXXXXXXXXXXXXXXXXXXTTDSSIY--QNFN--LIPRSFISNDEHSSNMSFVQMLNSPNYAQIDPAFFPNMPGIGNSFMMQSILNPNSSEQEIENPISNSSTYVLVPADXXXXXXXXXXXXXXAYGSLNLTNCGNNLFQYSSQSNQHQYPDINGNGPRLLHCKHEMQYPPDNISPFEYHLSKSIQNSSP-SPYKLSLPEIKTISNEWIKGSPXXXXXXXXXXXXXXXVSDYSNVKSLPQTLLNQNQTDSIYSSSINENRLPVNNFDSPNADREDDSETQDNPNQKXXXXXXXXXXXXXXXXXVGKKRKRRVLFSKKQILELERHFRQKKYLSAPEREHLANLIGLSPTQVKIWFQNHRYKMKRAHHEKSLEMGNLAVNRRISQTMFNDSKSHMPSNFDLGMXXXXXXXXXXXXXXXXXPAANLMGRIPGMSSMIPTYQNGPQSYFNSINPATLAGSNSSWG 1769
            MSSNGD VKYD+NFDREGYSTD+S +CP Q DD L+ I  S   ++FQL+ +N  A  NELHETF     I Q + +++  N    ++++           D SIY  Q F+  L+ R+FI NDE +SNMSFVQMLNS NY QI+PAF+ NMPGIGNSFMMQSILNPN ++QEI+NPIS++STYVLV  DSNI +NPQSN IN  Y SL+L +C +N+F+Y SQ+  HQYPDINGNGPRLLHCK E+ YP  NISPF+Y LS+S+Q+++P S YKLSLPEIKTISN+WIKGS   +NFNQNQ LR+ NVSDY+ +K+LPQ L N NQTDSIYSSSINEN  P+ N+DSPN DREDDSE  +NPN  DTSSVENNDN+NSSSGD+GKKRKRRVLFSKKQILELERHFRQKKYLSAPEREHLANLIGLSPTQVKIWFQNHRYKMKRAHHEK+LEMGNLAVNRR++Q+MFNDSKSH+P NF+LG+NNSFYNSNL+ GNLSLNPA NLMGRIPGMSSM+PTY NG QSYFN+IN ATL GSNSSWG
Sbjct:    1 MSSNGDSVKYDTNFDREGYSTDSSNECPNQIDDPLNGIPNSQNSENFQLYSRNNNA--NELHETFPTTIPIAQQVHLSSFRNSGMVNSNSRSI------GPDGSIYSIQPFDRALLQRNFIPNDEMTSNMSFVQMLNSANYDQIEPAFYQNMPGIGNSFMMQSILNPNPNDQEIDNPISDNSTYVLVQGDSNIPTNPQSNPINPTYVSLDLNDCRSNMFEYPSQTG-HQYPDINGNGPRLLHCKQELSYPQTNISPFDYRLSRSMQSNTPLSSYKLSLPEIKTISNDWIKGS-QNVNFNQNQLLRSTNVSDYTLIKNLPQNLPNPNQTDSIYSSSINENNQPIRNYDSPNPDREDDSEIHENPNPHDTSSVENNDNENSSSGDIGKKRKRRVLFSKKQILELERHFRQKKYLSAPEREHLANLIGLSPTQVKIWFQNHRYKMKRAHHEKALEMGNLAVNRRLNQSMFNDSKSHLPGNFELGINNSFYNSNLALGNLSLNPAVNLMGRIPGMSSMLPTYPNGSQSYFNNINQATLTGSNSSWG 532

[Close]

BLAST of Homeobox protein DTH-1 vs. UniProt/SwissProt
Match: sp|Q90481|NX22A_DANRE (Homeobox protein Nkx-2.2a OS=Danio rerio OX=7955 GN=nkx2.2a PE=2 SV=1)

HSP 1 Score: 127.872 bits (320), Expect = 9.796e-32
Identity = 58/79 (73.42%), Postives = 67/79 (84.81%), Query Frame = 3

Query: 1296 GKKRKRRVLFSKKQILELERHFRQKKYLSAPEREHLANLIGLSPTQVKIWFQNHRYKMKRAHHEKSLEMGNLAVNRRIS 1532
            GKKRKRRVLFSK Q  ELER FRQ++YLSAPEREHLA+LI L+PTQVKIWFQNHRYKMKRA  EK +E+ +L   RR++
Sbjct:  123 GKKRKRRVLFSKAQTYELERRFRQQRYLSAPEREHLASLIRLTPTQVKIWFQNHRYKMKRARAEKGMEVTHLPSPRRVA 201

[Close]

BLAST of Homeobox protein DTH-1 vs. UniProt/SwissProt
Match: sp|P42586|NKX22_MOUSE (Homeobox protein Nkx-2.2 OS=Mus musculus OX=10090 GN=Nkx2-2 PE=1 SV=2)

HSP 1 Score: 125.946 bits (315), Expect = 4.347e-31
Identity = 58/80 (72.50%), Postives = 66/80 (82.50%), Query Frame = 3

Query: 1293 VGKKRKRRVLFSKKQILELERHFRQKKYLSAPEREHLANLIGLSPTQVKIWFQNHRYKMKRAHHEKSLEMGNLAVNRRIS 1532
             GKKRKRRVLFSK Q  ELER FRQ++YLSAPEREHLA+LI L+PTQVKIWFQNHRYKMKRA  EK +E+  L   RR++
Sbjct:  125 AGKKRKRRVLFSKAQTYELERRFRQQRYLSAPEREHLASLIRLTPTQVKIWFQNHRYKMKRARAEKGMEVTPLPSPRRVA 204

[Close]

BLAST of Homeobox protein DTH-1 vs. UniProt/SwissProt
Match: sp|O95096|NKX22_HUMAN (Homeobox protein Nkx-2.2 OS=Homo sapiens OX=9606 GN=NKX2-2 PE=2 SV=1)

HSP 1 Score: 125.561 bits (314), Expect = 5.545e-31
Identity = 58/80 (72.50%), Postives = 66/80 (82.50%), Query Frame = 3

Query: 1293 VGKKRKRRVLFSKKQILELERHFRQKKYLSAPEREHLANLIGLSPTQVKIWFQNHRYKMKRAHHEKSLEMGNLAVNRRIS 1532
             GKKRKRRVLFSK Q  ELER FRQ++YLSAPEREHLA+LI L+PTQVKIWFQNHRYKMKRA  EK +E+  L   RR++
Sbjct:  125 AGKKRKRRVLFSKAQTYELERRFRQQRYLSAPEREHLASLIRLTPTQVKIWFQNHRYKMKRARAEKGMEVTPLPSPRRVA 204

[Close]

BLAST of Homeobox protein DTH-1 vs. UniProt/SwissProt
Match: sp|P42587|HNK2_XENLA (Homeobox protein XENK-2 OS=Xenopus laevis OX=8355 PE=2 SV=1)

HSP 1 Score: 122.865 bits (307), Expect = 8.367e-31
Identity = 58/79 (73.42%), Postives = 66/79 (83.54%), Query Frame = 3

Query: 1296 GKKRKRRVLFSKKQILELERHFRQKKYLSAPEREHLANLIGLSPTQVKIWFQNHRYKMKRAHHEKSLEMGNLAVNRRIS 1532
            GKKRKRRVLFSK Q  ELER FRQ++YLSAPEREHLA+LI L+PTQVKIWFQNHRYKMKRA  EK +E+  L   RR++
Sbjct:   67 GKKRKRRVLFSKAQTYELERRFRQQRYLSAPEREHLASLIRLTPTQVKIWFQNHRYKMKRARSEKGMEVTPLPSPRRVA 145

[Close]

BLAST of Homeobox protein DTH-1 vs. TrEMBL
Match: A0A444UL68 (Homeobox protein Nkx-2.2a OS=Acipenser ruthenus OX=7906 GN=EOD39_12434 PE=4 SV=1)

HSP 1 Score: 128.257 bits (321), Expect = 8.154e-30
Identity = 58/79 (73.42%), Postives = 67/79 (84.81%), Query Frame = 3

Query: 1296 GKKRKRRVLFSKKQILELERHFRQKKYLSAPEREHLANLIGLSPTQVKIWFQNHRYKMKRAHHEKSLEMGNLAVNRRIS 1532
            GKKRKRRVLFSK Q  ELER FRQ++YLSAPEREHLA+LI L+PTQVKIWFQNHRYKMKRA  EK +E+ +L   RR++
Sbjct:   84 GKKRKRRVLFSKAQTYELERRFRQQRYLSAPEREHLASLIRLTPTQVKIWFQNHRYKMKRARAEKGMEVSHLPSPRRVA 162

[Close]

BLAST of Homeobox protein DTH-1 vs. TrEMBL
Match: A0A553QS87 (Homeobox domain-containing protein OS=Danionella translucida OX=623744 GN=DNTS_024904 PE=4 SV=1)

HSP 1 Score: 127.872 bits (320), Expect = 2.264e-29
Identity = 58/79 (73.42%), Postives = 67/79 (84.81%), Query Frame = 3

Query: 1296 GKKRKRRVLFSKKQILELERHFRQKKYLSAPEREHLANLIGLSPTQVKIWFQNHRYKMKRAHHEKSLEMGNLAVNRRIS 1532
            GKKRKRRVLFSK Q  ELER FRQ++YLSAPEREHLA+LI L+PTQVKIWFQNHRYKMKRA  EK +E+ +L   RR++
Sbjct:  122 GKKRKRRVLFSKAQTYELERRFRQQRYLSAPEREHLASLIRLTPTQVKIWFQNHRYKMKRARAEKGMEVSHLPSPRRVA 200

[Close]

BLAST of Homeobox protein DTH-1 vs. TrEMBL
Match: A0A444TWQ6 (Homeobox protein Nkx-2.2a OS=Acipenser ruthenus OX=7906 GN=EOD39_3035 PE=4 SV=1)

HSP 1 Score: 127.872 bits (320), Expect = 2.481e-29
Identity = 58/79 (73.42%), Postives = 67/79 (84.81%), Query Frame = 3

Query: 1296 GKKRKRRVLFSKKQILELERHFRQKKYLSAPEREHLANLIGLSPTQVKIWFQNHRYKMKRAHHEKSLEMGNLAVNRRIS 1532
            GKKRKRRVLFSK Q  ELER FRQ++YLSAPEREHLA+LI L+PTQVKIWFQNHRYKMKRA  EK +E+ +L   RR++
Sbjct:  126 GKKRKRRVLFSKAQTYELERRFRQQRYLSAPEREHLASLIRLTPTQVKIWFQNHRYKMKRARAEKGMEVSHLPSPRRVA 204

[Close]

BLAST of Homeobox protein DTH-1 vs. TrEMBL
Match: A0A3B3QFH1 (NK2 homeobox 2a OS=Paramormyrops kingsleyae OX=1676925 PE=4 SV=1)

HSP 1 Score: 127.872 bits (320), Expect = 2.671e-29
Identity = 58/79 (73.42%), Postives = 67/79 (84.81%), Query Frame = 3

Query: 1296 GKKRKRRVLFSKKQILELERHFRQKKYLSAPEREHLANLIGLSPTQVKIWFQNHRYKMKRAHHEKSLEMGNLAVNRRIS 1532
            GKKRKRRVLFSK Q  ELER FRQ++YLSAPEREHLA+LI L+PTQVKIWFQNHRYKMKRA  EK +E+ +L   RR++
Sbjct:  124 GKKRKRRVLFSKAQTYELERRFRQQRYLSAPEREHLASLIRLTPTQVKIWFQNHRYKMKRARAEKGMEVTHLPSPRRVA 202

[Close]

BLAST of Homeobox protein DTH-1 vs. TrEMBL
Match: Q1RM24 (NK2 transcription factor related 2a OS=Danio rerio OX=7955 GN=nkx2.2a PE=2 SV=1)

HSP 1 Score: 127.872 bits (320), Expect = 2.903e-29
Identity = 58/79 (73.42%), Postives = 67/79 (84.81%), Query Frame = 3

Query: 1296 GKKRKRRVLFSKKQILELERHFRQKKYLSAPEREHLANLIGLSPTQVKIWFQNHRYKMKRAHHEKSLEMGNLAVNRRIS 1532
            GKKRKRRVLFSK Q  ELER FRQ++YLSAPEREHLA+LI L+PTQVKIWFQNHRYKMKRA  EK +E+ +L   RR++
Sbjct:  123 GKKRKRRVLFSKAQTYELERRFRQQRYLSAPEREHLASLIRLTPTQVKIWFQNHRYKMKRARAEKGMEVTHLPSPRRVA 201

[Close]

BLAST of Homeobox protein DTH-1 vs. Ensembl Cavefish
Match: ENSAMXT00000002203.2 (pep primary_assembly:Astyanax_mexicanus-2.0:9:20913167:20916891:1 gene:ENSAMXG00000002158.2 transcript:ENSAMXT00000002203.2 gene_biotype:protein_coding transcript_biotype:protein_coding)

HSP 1 Score: 105.145 bits (261), Expect = 5.365e-26
Identity = 53/88 (60.23%), Postives = 63/88 (71.59%), Query Frame = 3

Query: 1299 KKRKRRVLFSKKQILELERHFRQKKYLSAPEREHLANLIGLSPTQVKIWFQNHRYKMKRAHHEKSLEMGNL--AVNRRISQTMFNDSK 1556
            KK+KRRVLFSK Q  ELER FRQ++YLSAPEREHLA  + L+PTQVKIWFQNHRYKMKRA  E  ++      ++ R I   +  D K
Sbjct:   16 KKKKRRVLFSKTQTYELERRFRQQRYLSAPEREHLARALRLTPTQVKIWFQNHRYKMKRARTECGVQEAGQPPSLRRVIVPVLVRDGK 103

[Close]

BLAST of Homeobox protein DTH-1 vs. Ensembl Cavefish
Match: nkx2.1 (homeobox protein Nkx-2.1 [Source:NCBI gene;Acc:103043023])

HSP 1 Score: 108.227 bits (269), Expect = 2.845e-25
Identity = 47/63 (74.60%), Postives = 56/63 (88.89%), Query Frame = 3

Query: 1302 KRKRRVLFSKKQILELERHFRQKKYLSAPEREHLANLIGLSPTQVKIWFQNHRYKMKRAHHEK 1490
            +RKRRVLFS+ Q+ ELER F+Q+KYLSAPEREHLA++I L+PTQVKIWFQNHRYKMKR   +K
Sbjct:  160 RRKRRVLFSQAQVYELERRFKQQKYLSAPEREHLASMIHLTPTQVKIWFQNHRYKMKRQAKDK 222

[Close]

BLAST of Homeobox protein DTH-1 vs. Ensembl Cavefish
Match: nkx2.5 (homeobox protein Nkx-2.5 [Source:NCBI gene;Acc:103025318])

HSP 1 Score: 104.76 bits (260), Expect = 2.440e-24
Identity = 47/78 (60.26%), Postives = 57/78 (73.08%), Query Frame = 3

Query: 1299 KKRKRRVLFSKKQILELERHFRQKKYLSAPEREHLANLIGLSPTQVKIWFQNHRYKMKRAHHEKSLEMGNLAVNRRIS 1532
            K+RK RVLFS+ Q+ ELER F Q++YLSA EREHLA  + L+ TQVKIWFQN RYK KR   E++LE   L   RR+S
Sbjct:  131 KRRKPRVLFSQAQVCELERRFTQQRYLSAAEREHLAGALRLTSTQVKIWFQNRRYKCKRQRQERALEAAGLGAPRRVS 208

[Close]

BLAST of Homeobox protein DTH-1 vs. Ensembl Cavefish
Match: nkx2.4b (NK2 homeobox 4 [Source:NCBI gene;Acc:103036401])

HSP 1 Score: 103.605 bits (257), Expect = 7.231e-24
Identity = 45/63 (71.43%), Postives = 55/63 (87.30%), Query Frame = 3

Query: 1302 KRKRRVLFSKKQILELERHFRQKKYLSAPEREHLANLIGLSPTQVKIWFQNHRYKMKRAHHEK 1490
            +RKRRVLFS+ Q+ ELER F+Q++YLSAPEREHLA++I L+P QVKIWFQNHRYKMKR   +K
Sbjct:  143 RRKRRVLFSQAQVYELERRFKQQRYLSAPEREHLASMIHLTPNQVKIWFQNHRYKMKRQAKDK 205

[Close]

BLAST of Homeobox protein DTH-1 vs. Ensembl Cavefish
Match: nkx2.2b (homeobox protein Nkx-2.2-like [Source:NCBI gene;Acc:107197780])

HSP 1 Score: 95.1301 bits (235), Expect = 9.203e-22
Identity = 49/93 (52.69%), Postives = 60/93 (64.52%), Query Frame = 3

Query: 1317 VLFSKKQILELERHFRQKKYLSAPEREHLANLIGLSPTQVKIWFQNHRYKMKRAHHEKSLEMGNLAVNRRISQTMFNDSKS---HMPSNFDLG 1586
            VLFS+ Q  ELER FRQ++YLS PEREHLA+ + L+PTQVKIWFQNHRYKMKRA   + L +  L  + R      +D  +   H    F LG
Sbjct:  107 VLFSRAQTCELERRFRQQRYLSGPEREHLAHSLRLTPTQVKIWFQNHRYKMKRAERGRELAVPILLRDHRTCSVKPHDFVAPLLHTGLQFPLG 199

[Close]

BLAST of Homeobox protein DTH-1 vs. Ensembl Sea Lamprey
Match: ENSPMAT00000005776.1 (pep scaffold:Pmarinus_7.0:GL477528:542110:542457:1 gene:ENSPMAG00000005236.1 transcript:ENSPMAT00000005776.1 gene_biotype:protein_coding transcript_biotype:protein_coding)

HSP 1 Score: 105.145 bits (261), Expect = 1.636e-27
Identity = 50/66 (75.76%), Postives = 57/66 (86.36%), Query Frame = 3

Query: 1299 KKRKRRVLFSKKQILELERHFRQKKYLSAPEREHLANLIGLSPTQVKIWFQNHRYKMKRAHHEKSL 1496
            KKRKRRVLFSK Q  ELER FR ++YLSAPEREHLA+L+ L+PTQVKIWFQNHRYKMKRA  E+ +
Sbjct:    1 KKRKRRVLFSKAQTFELERRFRHQRYLSAPEREHLASLLKLTPTQVKIWFQNHRYKMKRARVEQGI 66

[Close]

BLAST of Homeobox protein DTH-1 vs. Ensembl Sea Lamprey
Match: nkx2.1 (NK2 homeobox 1 [Source:ZFIN;Acc:ZDB-GENE-010404-1])

HSP 1 Score: 107.842 bits (268), Expect = 7.521e-27
Identity = 47/63 (74.60%), Postives = 56/63 (88.89%), Query Frame = 3

Query: 1302 KRKRRVLFSKKQILELERHFRQKKYLSAPEREHLANLIGLSPTQVKIWFQNHRYKMKRAHHEK 1490
            +RKRRVLFS+ Q+ ELER F+Q+KYLSAPEREHLA++I L+PTQVKIWFQNHRYKMKR   +K
Sbjct:   40 RRKRRVLFSQAQVYELERRFKQQKYLSAPEREHLASMIHLTPTQVKIWFQNHRYKMKRQAKDK 102

[Close]

BLAST of Homeobox protein DTH-1 vs. Ensembl Sea Lamprey
Match: ENSPMAT00000001141.1 (pep scaffold:Pmarinus_7.0:GL478075:36995:38394:-1 gene:ENSPMAG00000001023.1 transcript:ENSPMAT00000001141.1 gene_biotype:protein_coding transcript_biotype:protein_coding)

HSP 1 Score: 71.2478 bits (173), Expect = 1.505e-15
Identity = 34/61 (55.74%), Postives = 45/61 (73.77%), Query Frame = 3

Query: 1296 GKKRKRRVLFSKKQILELERHFRQKKYLSAPEREHLANLIGLSPTQVKIWFQNHRYKMKRA 1478
            GK R+ R  FS +Q+LELERHF +++YLS P+R  +A+ + L+ TQVKIWFQN R K KR 
Sbjct:    1 GKCRRPRTAFSSQQLLELERHFSRQRYLSRPQRFQVASALMLTETQVKIWFQNRRMKWKRG 61

[Close]

BLAST of Homeobox protein DTH-1 vs. Ensembl Sea Lamprey
Match: dlx5a (distal-less homeobox 5a [Source:NCBI gene;Acc:30569])

HSP 1 Score: 69.3218 bits (168), Expect = 7.999e-13
Identity = 31/59 (52.54%), Postives = 41/59 (69.49%), Query Frame = 3

Query: 1299 KKRKRRVLFSKKQILELERHFRQKKYLSAPEREHLANLIGLSPTQVKIWFQNHRYKMKR 1475
            K RK R ++S  Q+  L+R F+Q +YL+ PER  LA  +GL+ TQVKIWFQN R K K+
Sbjct:  201 KIRKPRTIYSSFQLAALQRRFQQTQYLALPERAELAASLGLTQTQVKIWFQNRRSKFKK 259

[Close]

BLAST of Homeobox protein DTH-1 vs. Ensembl Sea Lamprey
Match: HMX1 (H6 family homeobox 1 [Source:HGNC Symbol;Acc:HGNC:5017])

HSP 1 Score: 63.929 bits (154), Expect = 1.145e-12
Identity = 31/58 (53.45%), Postives = 40/58 (68.97%), Query Frame = 3

Query: 1302 KRKRRVLFSKKQILELERHFRQKKYLSAPEREHLANLIGLSPTQVKIWFQNHRYKMKR 1475
            K+K R +FS+ Q+ +LE  F  K+YLS+ ER  LA  + L+ TQVKIWFQN R K KR
Sbjct:    1 KKKTRTVFSRSQVFQLESTFDMKRYLSSAERAGLAASLHLTETQVKIWFQNRRNKWKR 58

[Close]

BLAST of Homeobox protein DTH-1 vs. Ensembl Yeast
Match: HMRA1 (Silenced copy of a1 at HMR; homeobox corepressor that interacts with Alpha2p to repress haploid-specific gene transcription in diploid cells [Source:SGD;Acc:S000000694])

HSP 1 Score: 44.2838 bits (103), Expect = 4.834e-6
Identity = 18/42 (42.86%), Postives = 30/42 (71.43%), Query Frame = 3

Query: 1347 LERHFRQKKYLSAPEREHLANLIGLSPTQVKIWFQNHRYKMK 1472
            LE+ FR+K+ L++ E+E +A   G++P QV++WF N R + K
Sbjct:   85 LEQVFRRKQSLNSKEKEEVAKKCGITPLQVRVWFINKRMRSK 126

[Close]

BLAST of Homeobox protein DTH-1 vs. Ensembl Nematostella
Match: EDO33946 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7SQP5])

HSP 1 Score: 101.679 bits (252), Expect = 1.452e-25
Identity = 47/65 (72.31%), Postives = 55/65 (84.62%), Query Frame = 3

Query: 1299 KKRKRRVLFSKKQILELERHFRQKKYLSAPEREHLANLIGLSPTQVKIWFQNHRYKMKRAHHEKS 1493
            KKRKRRVLF+K Q  ELER FRQ++YLSAPERE LA +I L+PTQVKIWFQNHRYK K+ ++EK 
Sbjct:    6 KKRKRRVLFTKAQTYELERRFRQQRYLSAPEREQLARIINLTPTQVKIWFQNHRYKFKKQNYEKG 70

[Close]

BLAST of Homeobox protein DTH-1 vs. Ensembl Nematostella
Match: NK-2 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7SQP7])

HSP 1 Score: 98.9821 bits (245), Expect = 1.679e-23
Identity = 45/64 (70.31%), Postives = 53/64 (82.81%), Query Frame = 3

Query: 1299 KKRKRRVLFSKKQILELERHFRQKKYLSAPEREHLANLIGLSPTQVKIWFQNHRYKMKRAHHEK 1490
            +K+KRR+LF+K QI ELER FRQ+KYLSA ERE LA +I L+PTQVKIWFQNHRYK K+   EK
Sbjct:   90 RKKKRRILFTKSQIFELERRFRQQKYLSANEREQLARIIDLTPTQVKIWFQNHRYKFKKQIGEK 153

[Close]

BLAST of Homeobox protein DTH-1 vs. Ensembl Nematostella
Match: EDO33947 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7SQP6])

HSP 1 Score: 93.9745 bits (232), Expect = 2.472e-23
Identity = 44/63 (69.84%), Postives = 51/63 (80.95%), Query Frame = 3

Query: 1299 KKRKRRVLFSKKQILELERHFRQKKYLSAPEREHLANLIGLSPTQVKIWFQNHRYKMKRAHHE 1487
            KKRKRR+LF+K QI ELER FR ++YLSAPERE L  +I L+PTQVKIWFQNHRYK K+   E
Sbjct:    1 KKRKRRILFTKSQIYELERRFRYQRYLSAPEREQLGRMINLTPTQVKIWFQNHRYKHKKQASE 63

[Close]

BLAST of Homeobox protein DTH-1 vs. Ensembl Nematostella
Match: EDO45871 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7RRR7])

HSP 1 Score: 88.5817 bits (218), Expect = 1.067e-21
Identity = 39/62 (62.90%), Postives = 52/62 (83.87%), Query Frame = 3

Query: 1302 KRKRRVLFSKKQILELERHFRQKKYLSAPEREHLANLIGLSPTQVKIWFQNHRYKMKRAHHE 1487
            K+K+R+LF++ QI ELER FR ++YLSAPEREHLA +I L+P QVKIWFQNHRYK ++ + +
Sbjct:    1 KKKKRILFTRSQIYELERRFRVQQYLSAPEREHLARMISLTPVQVKIWFQNHRYKCRQRYKQ 62

[Close]

BLAST of Homeobox protein DTH-1 vs. Ensembl Nematostella
Match: EDO33963 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7SQP4])

HSP 1 Score: 84.3445 bits (207), Expect = 2.688e-20
Identity = 41/64 (64.06%), Postives = 49/64 (76.56%), Query Frame = 3

Query: 1299 KKRKRRVLFSKKQILELERHFRQKKYLSAPEREHLANLIGLSPTQVKIWFQNHRYKMKRAHHEK 1490
            KKRKRR+LF+K Q   LER F Q++YLSAPERE LA +  L+P QVKIWFQNHRYK ++   EK
Sbjct:    3 KKRKRRILFTKAQTFILERRFTQQRYLSAPEREELARIANLTPAQVKIWFQNHRYKYRKQMSEK 66

[Close]

BLAST of Homeobox protein DTH-1 vs. Ensembl Medaka
Match: nkx2.2a (homeobox protein Nkx-2.2a [Source:NCBI gene;Acc:101157822])

HSP 1 Score: 124.79 bits (312), Expect = 1.388e-31
Identity = 57/78 (73.08%), Postives = 66/78 (84.62%), Query Frame = 3

Query: 1299 KKRKRRVLFSKKQILELERHFRQKKYLSAPEREHLANLIGLSPTQVKIWFQNHRYKMKRAHHEKSLEMGNLAVNRRIS 1532
            KKRKRRVLFSK Q  ELER FRQ++YLSAPEREHLA+LI L+PTQVKIWFQNHRYKMKRA  EK +E+ +L   RR++
Sbjct:  128 KKRKRRVLFSKAQTYELERRFRQQRYLSAPEREHLASLIRLTPTQVKIWFQNHRYKMKRARAEKGMEVTHLPSPRRVA 205

[Close]

BLAST of Homeobox protein DTH-1 vs. Ensembl Medaka
Match: nkx2.2a (homeobox protein Nkx-2.2a [Source:NCBI gene;Acc:101157822])

HSP 1 Score: 124.79 bits (312), Expect = 1.708e-31
Identity = 57/78 (73.08%), Postives = 66/78 (84.62%), Query Frame = 3

Query: 1299 KKRKRRVLFSKKQILELERHFRQKKYLSAPEREHLANLIGLSPTQVKIWFQNHRYKMKRAHHEKSLEMGNLAVNRRIS 1532
            KKRKRRVLFSK Q  ELER FRQ++YLSAPEREHLA+LI L+PTQVKIWFQNHRYKMKRA  EK +E+ +L   RR++
Sbjct:  134 KKRKRRVLFSKAQTYELERRFRQQRYLSAPEREHLASLIRLTPTQVKIWFQNHRYKMKRARAEKGMEVTHLPSPRRVA 211

[Close]

BLAST of Homeobox protein DTH-1 vs. Ensembl Medaka
Match: nkx2.2a (homeobox protein Nkx-2.2a [Source:NCBI gene;Acc:101157822])

HSP 1 Score: 120.553 bits (301), Expect = 2.631e-30
Identity = 55/68 (80.88%), Postives = 60/68 (88.24%), Query Frame = 3

Query: 1299 KKRKRRVLFSKKQILELERHFRQKKYLSAPEREHLANLIGLSPTQVKIWFQNHRYKMKRAHHEKSLEM 1502
            KKRKRRVLFSK Q  ELER FRQ++YLSAPEREHLA+LI L+PTQVKIWFQNHRYKMKRA  EK LE+
Sbjct:  128 KKRKRRVLFSKAQTYELERRFRQQRYLSAPEREHLASLIRLTPTQVKIWFQNHRYKMKRARAEKGLEL 195

[Close]

BLAST of Homeobox protein DTH-1 vs. Ensembl Medaka
Match: NKX2-8 (NK2 homeobox 8 [Source:NCBI gene;Acc:101166096])

HSP 1 Score: 108.612 bits (270), Expect = 2.348e-26
Identity = 58/136 (42.65%), Postives = 75/136 (55.15%), Query Frame = 3

Query: 1185 SPNADREDDSETQDNPNQKXXXXXXXXXXXXXXXXXVGKKRKRRVLFSKKQILELERHFRQKKYLSAPEREHLANLIGLSPTQVKIWFQNHRYKMKRAHHEKSLEMGNLA----VNRRISQTMFNDSKSHMPSNFD 1580
            SP++ + DDS     P +                    K +KRRVLFSK Q LELER FRQ++YLS PERE LA ++ L+PTQVKIWFQNHRYKMKR   E +L+  + A    + R +   +  + K   P   D
Sbjct:   57 SPDSTKPDDSALDSEPQR------------------TQKSKKRRVLFSKAQTLELERRFRQQRYLSGPEREQLARMLSLTPTQVKIWFQNHRYKMKRGRVEGALQDADAAQPPVLRRVVVPILVREGKPFHPCFLD 174

[Close]

BLAST of Homeobox protein DTH-1 vs. Ensembl Medaka
Match: nkx2.1 (NK2 homeobox 1 [Source:NCBI gene;Acc:100049404])

HSP 1 Score: 108.997 bits (271), Expect = 1.538e-25
Identity = 47/64 (73.44%), Postives = 57/64 (89.06%), Query Frame = 3

Query: 1302 KRKRRVLFSKKQILELERHFRQKKYLSAPEREHLANLIGLSPTQVKIWFQNHRYKMKRAHHEKS 1493
            +RKRRVLFS+ Q+ ELER F+Q+KYLSAPEREHLA++I L+PTQVKIWFQNHRYKMKR   +K+
Sbjct:  159 RRKRRVLFSQAQVYELERRFKQQKYLSAPEREHLASMIHLTPTQVKIWFQNHRYKMKRQAKDKA 222

[Close]

BLAST of Homeobox protein DTH-1 vs. Planmine SMEST
Match: SMESG000079512.1 (SMESG000079512.1)

HSP 1 Score: 858.981 bits (2218), Expect = 0.000e+0
Identity = 496/538 (92.19%), Postives = 500/538 (92.94%), Query Frame = 3

Query:  159 MSSNGDCVKYDSNFDREGYSTDTSTDCPIQTDDSLHEIQTSSLPDSFQLFPQNTKAHINELHETFSAANSITQHLQVXXXXXXXXXXXXXXXXXXXXXXTTDSSIYQNFNLIPRSFISNDEHSSNMSFVQMLNSPNYAQIDPAFFPNMPGIGNSFMMQSILNPNSSEQEIENPISNSSTYVLVPADXXXXXXXXXXXXXXAYGSLNLTNCGNNLFQYSSQSNQHQYPDINGNGPRLLHCKHEMQYPPDNISPFEYHLSKSIQNSSPSPYKLSLPEIKTISNEWIKGSPXXXXXXXXXXXXXXXVSDYSNVKSLPQTLLNQNQTDSIYSSSINENRLPVNNFDSPNADREDDSETQDNPNQKXXXXXXXXXXXXXXXXXVGKKRKRRVLFSKKQILELERHFRQKKYLSAPEREHLANLIGLSPTQVKIWFQNHRYKMKRAHHEKSLEMGNLAVNRRISQTMFNDSKSHMPSNFDLGMXXXXXXXXXXXXXXXXXPAANLMGRIPGMSSMIPTYQNGPQSYFNSINPATLAGSNSSWGH 1772
            MSSNGDCVKYDSNFDREGYSTDTSTDCPIQTDDSLHEIQTSSLPDSFQLFPQNTKAHINELHETFSAANSITQHLQVNNNN+                   +SSIYQNFNLIPRSFISNDEHSSNMSFVQMLNSPNYAQIDPAFFPNMPGIGNSFMMQSILNPNSSEQEIENPISNSSTYVLVPADSNIQSNPQSNSINSAYGSLNLTNCGNNLFQYS+QSNQHQYPDINGNGPRLLHCKHEMQYPPDNISPFEYHLSKSIQNSSPSPYKLSLPEIKTISNEWIKGSPNIINFNQNQRLRNQNVSDYSNVKSLPQTLLNQNQTDSIYSSSINENRL VNNFDSPNADREDDSETQDNPNQKDTSSVENNDNDNSSSGDVGKKRKRRVLFSKKQILELERHFRQKKYLSAPEREHLANLIGLSPTQVKIWFQNHRYKMKRAHHEKSLEMGNLAVNRRISQTMFNDSKSHMPSNFDLGMNNSFYN             +NL     GMSSMIPTYQNGPQSYFNSINPATLAGSNSSWGH
Sbjct:    1 MSSNGDCVKYDSNFDREGYSTDTSTDCPIQTDDSLHEIQTSSLPDSFQLFPQNTKAHINELHETFSAANSITQHLQVNNNNHI----------------NYNSSIYQNFNLIPRSFISNDEHSSNMSFVQMLNSPNYAQIDPAFFPNMPGIGNSFMMQSILNPNSSEQEIENPISNSSTYVLVPADSNIQSNPQSNSINSAYGSLNLTNCGNNLFQYSNQSNQHQYPDINGNGPRLLHCKHEMQYPPDNISPFEYHLSKSIQNSSPSPYKLSLPEIKTISNEWIKGSPNIINFNQNQRLRNQNVSDYSNVKSLPQTLLNQNQTDSIYSSSINENRLQVNNFDSPNADREDDSETQDNPNQKDTSSVENNDNDNSSSGDVGKKRKRRVLFSKKQILELERHFRQKKYLSAPEREHLANLIGLSPTQVKIWFQNHRYKMKRAHHEKSLEMGNLAVNRRISQTMFNDSKSHMPSNFDLGMNNSFYN-------------SNLSF---GMSSMIPTYQNGPQSYFNSINPATLAGSNSSWGH 506

[Close]

BLAST of Homeobox protein DTH-1 vs. Planmine SMEST
Match: SMESG000037282.1 (SMESG000037282.1)

HSP 1 Score: 112.849 bits (281), Expect = 7.284e-27
Identity = 49/69 (71.01%), Postives = 59/69 (85.51%), Query Frame = 3

Query: 1293 VGKKRKRRVLFSKKQILELERHFRQKKYLSAPEREHLANLIGLSPTQVKIWFQNHRYKMKRAHHEKSLE 1499
            + ++RKRR+LFS+ QI ELER F+Q+KYLSAPEREHLANLI L+PTQVKIWFQNHRYK KR+  +K  E
Sbjct:  121 ISQRRKRRILFSQAQIYELERRFKQQKYLSAPEREHLANLINLTPTQVKIWFQNHRYKCKRSQKDKEKE 189

[Close]

BLAST of Homeobox protein DTH-1 vs. Planmine SMEST
Match: SMESG000037282.1 (SMESG000037282.1)

HSP 1 Score: 112.849 bits (281), Expect = 8.832e-27
Identity = 49/69 (71.01%), Postives = 59/69 (85.51%), Query Frame = 3

Query: 1293 VGKKRKRRVLFSKKQILELERHFRQKKYLSAPEREHLANLIGLSPTQVKIWFQNHRYKMKRAHHEKSLE 1499
            + ++RKRR+LFS+ QI ELER F+Q+KYLSAPEREHLANLI L+PTQVKIWFQNHRYK KR+  +K  E
Sbjct:  130 ISQRRKRRILFSQAQIYELERRFKQQKYLSAPEREHLANLINLTPTQVKIWFQNHRYKCKRSQKDKEKE 198

[Close]

BLAST of Homeobox protein DTH-1 vs. Planmine SMEST
Match: SMESG000081885.1 (SMESG000081885.1)

HSP 1 Score: 97.4413 bits (241), Expect = 1.653e-21
Identity = 41/57 (71.93%), Postives = 50/57 (87.72%), Query Frame = 3

Query: 1317 VLFSKKQILELERHFRQKKYLSAPEREHLANLIGLSPTQVKIWFQNHRYKMKRAHHE 1487
            +LFS+ Q+ ELER F+Q+KYLSAPEREHLA+LI L+PTQVKIWFQNHRYK KR+  +
Sbjct:  136 ILFSQAQVYELERRFKQQKYLSAPEREHLASLINLTPTQVKIWFQNHRYKCKRSQKD 192

[Close]

BLAST of Homeobox protein DTH-1 vs. Planmine SMEST
Match: SMESG000062916.1 (SMESG000062916.1)

HSP 1 Score: 93.9745 bits (232), Expect = 3.690e-21
Identity = 43/69 (62.32%), Postives = 53/69 (76.81%), Query Frame = 3

Query: 1293 VGKKRKRRVLFSKKQILELERHFRQKKYLSAPEREHLANLIGLSPTQVKIWFQNHRYKMKRAHHEKSLE 1499
             G++RKRR+LFS+ Q+ ELER F+ +KYLSA ER+ LA  I L+P QVKIWFQNHRYK KR   EK +E
Sbjct:  127 FGQRRKRRILFSQSQVYELERKFKHQKYLSASERDQLAQTINLTPNQVKIWFQNHRYKCKRI--EKDME 193

The following BLAST results are available for this feature:

BLAST of Homeobox protein DTH-1 vs. Ensembl Human
BLAST of Homeobox protein DTH-1 vs. Ensembl Celegans
BLAST of Homeobox protein DTH-1 vs. Ensembl Fly
BLAST of Homeobox protein DTH-1 vs. Ensembl Zebrafish
BLAST of Homeobox protein DTH-1 vs. Ensembl Xenopus
BLAST of Homeobox protein DTH-1 vs. Ensembl Mouse
BLAST of Homeobox protein DTH-1 vs. UniProt/SwissProt
BLAST of Homeobox protein DTH-1 vs. TrEMBL
BLAST of Homeobox protein DTH-1 vs. Ensembl Cavefish
BLAST of Homeobox protein DTH-1 vs. Ensembl Sea Lamprey
BLAST of Homeobox protein DTH-1 vs. Ensembl Yeast
BLAST of Homeobox protein DTH-1 vs. Ensembl Nematostella
BLAST of Homeobox protein DTH-1 vs. Ensembl Medaka
BLAST of Homeobox protein DTH-1 vs. Planmine SMEST

BLAST of Homeobox protein DTH-1 vs. Ensembl Human
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Human e!99)
Total hits: 5


Match Name	E-value	Identity	Description
NKX2-2	1.155e-31	72.50	NK2 homeobox 2 [Source:HGNC Symbol;Acc:HGNC:7835]	[more]
NKX2-8	1.645e-26	64.94	NK2 homeobox 8 [Source:HGNC Symbol;Acc:HGNC:16364]	[more]
NKX2-4	8.590e-25	71.21	NK2 homeobox 4 [Source:HGNC Symbol;Acc:HGNC:7837]	[more]
NKX2-1	9.644e-25	73.44	NK2 homeobox 1 [Source:HGNC Symbol;Acc:HGNC:11825]	[more]
NKX2-1	9.644e-25	73.44	NK2 homeobox 1 [Source:HGNC Symbol;Acc:HGNC:11825]	[more]

BLAST of Homeobox protein DTH-1 vs. Ensembl Celegans
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99)
Total hits: 5


Match Name	E-value	Identity	Description
ceh-24	4.667e-24	67.65	Homeobox protein ceh-24 [Source:UniProtKB/Swiss-P...	[more]
ceh-22	4.583e-21	62.69	Homeobox protein ceh-22 [Source:UniProtKB/Swiss-P...	[more]
ceh-22	6.961e-21	62.69	Homeobox protein ceh-22 [Source:UniProtKB/Swiss-P...	[more]
ceh-22	1.105e-20	62.69	Homeobox protein ceh-22 [Source:UniProtKB/Swiss-P...	[more]
ceh-22	3.099e-20	62.69	Homeobox protein ceh-22 [Source:UniProtKB/Swiss-P...	[more]

BLAST of Homeobox protein DTH-1 vs. Ensembl Fly
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99)
Total hits: 5


Match Name	E-value	Identity	Description
scro	2.571e-26	67.65	gene:FBgn0028993 transcript:FBtr0339923	[more]
vnd	4.437e-26	77.61	gene:FBgn0261930 transcript:FBtr0110929	[more]
vnd	6.839e-26	77.61	gene:FBgn0261930 transcript:FBtr0070110	[more]
scro	2.061e-25	67.65	gene:FBgn0028993 transcript:FBtr0113751	[more]
tin	3.091e-16	66.10	gene:FBgn0004110 transcript:FBtr0084086	[more]

BLAST of Homeobox protein DTH-1 vs. Ensembl Zebrafish
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99)
Total hits: 5


Match Name	E-value	Identity	Description
nkx2.2a	1.298e-32	73.42	NK2 homeobox 2a [Source:NCBI gene;Acc:30697]	[more]
nkx2.2a	1.298e-32	73.42	NK2 homeobox 2a [Source:NCBI gene;Acc:30697]	[more]
nkx2.2a	1.574e-32	73.42	NK2 homeobox 2a [Source:NCBI gene;Acc:30697]	[more]
nkx2.2a	1.574e-32	73.42	NK2 homeobox 2a [Source:NCBI gene;Acc:30697]	[more]
nkx2.2a	1.574e-32	73.42	NK2 homeobox 2a [Source:NCBI gene;Acc:30697]	[more]

BLAST of Homeobox protein DTH-1 vs. Ensembl Xenopus
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99)
Total hits: 5


Match Name	E-value	Identity	Description
NKX2-2	3.955e-32	73.42	NK2 homeobox 2 [Source:NCBI gene;Acc:100038077]	[more]
fam221a	1.768e-25	71.21	family with sequence similarity 221 member A [Sour...	[more]
trpc3	3.509e-25	74.60	transient receptor potential cation channel, subfa...	[more]
NKX2-3	8.119e-24	69.12	NK2 homeobox 3 [Source:NCBI gene;Acc:100486189]	[more]
mtm1	1.045e-22	57.69	myotubularin 1 [Source:Xenbase;Acc:XB-GENE-1002030...	[more]

BLAST of Homeobox protein DTH-1 vs. Ensembl Mouse
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99)
Total hits: 5


Match Name	E-value	Identity	Description
Nkx2-2	6.214e-32	72.50	NK2 homeobox 2 [Source:MGI Symbol;Acc:MGI:97347]	[more]
Nkx2-2	1.379e-29	72.15	NK2 homeobox 2 [Source:MGI Symbol;Acc:MGI:97347]	[more]
Nkx2-9	1.411e-25	66.22	NK2 homeobox 9 [Source:MGI Symbol;Acc:MGI:1270158]	[more]
Nkx2-4	1.892e-25	71.21	NK2 homeobox 4 [Source:MGI Symbol;Acc:MGI:97349]	[more]
Nkx2-1	9.583e-25	73.44	NK2 homeobox 1 [Source:MGI Symbol;Acc:MGI:108067]	[more]

BLAST of Homeobox protein DTH-1 vs. UniProt/SwissProt
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt)
Total hits: 5


Match Name	E-value	Identity	Description
sp\|Q00400\|DTH1_GIRTI	0.000e+0	70.66	Homeobox protein DTH-1 OS=Girardia tigrina OX=6162...	[more]
sp\|Q90481\|NX22A_DANRE	9.796e-32	73.42	Homeobox protein Nkx-2.2a OS=Danio rerio OX=7955 G...	[more]
sp\|P42586\|NKX22_MOUSE	4.347e-31	72.50	Homeobox protein Nkx-2.2 OS=Mus musculus OX=10090 ...	[more]
sp\|O95096\|NKX22_HUMAN	5.545e-31	72.50	Homeobox protein Nkx-2.2 OS=Homo sapiens OX=9606 G...	[more]
sp\|P42587\|HNK2_XENLA	8.367e-31	73.42	Homeobox protein XENK-2 OS=Xenopus laevis OX=8355 ...	[more]

BLAST of Homeobox protein DTH-1 vs. TrEMBL
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL)
Total hits: 5


Match Name	E-value	Identity	Description
A0A444UL68	8.154e-30	73.42	Homeobox protein Nkx-2.2a OS=Acipenser ruthenus OX...	[more]
A0A553QS87	2.264e-29	73.42	Homeobox domain-containing protein OS=Danionella t...	[more]
A0A444TWQ6	2.481e-29	73.42	Homeobox protein Nkx-2.2a OS=Acipenser ruthenus OX...	[more]
A0A3B3QFH1	2.671e-29	73.42	NK2 homeobox 2a OS=Paramormyrops kingsleyae OX=167...	[more]
Q1RM24	2.903e-29	73.42	NK2 transcription factor related 2a OS=Danio rerio...	[more]

BLAST of Homeobox protein DTH-1 vs. Ensembl Cavefish
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99)
Total hits: 5


Match Name	E-value	Identity	Description
ENSAMXT00000002203.2	5.365e-26	60.23	pep primary_assembly:Astyanax_mexicanus-2.0:9:2091...	[more]
nkx2.1	2.845e-25	74.60	homeobox protein Nkx-2.1 [Source:NCBI gene;Acc:103...	[more]
nkx2.5	2.440e-24	60.26	homeobox protein Nkx-2.5 [Source:NCBI gene;Acc:103...	[more]
nkx2.4b	7.231e-24	71.43	NK2 homeobox 4 [Source:NCBI gene;Acc:103036401]	[more]
nkx2.2b	9.203e-22	52.69	homeobox protein Nkx-2.2-like [Source:NCBI gene;Ac...	[more]

BLAST of Homeobox protein DTH-1 vs. Ensembl Sea Lamprey
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99)
Total hits: 5


Match Name	E-value	Identity	Description
ENSPMAT00000005776.1	1.636e-27	75.76	pep scaffold:Pmarinus_7.0:GL477528:542110:542457:1...	[more]
nkx2.1	7.521e-27	74.60	NK2 homeobox 1 [Source:ZFIN;Acc:ZDB-GENE-010404-1]	[more]
ENSPMAT00000001141.1	1.505e-15	55.74	pep scaffold:Pmarinus_7.0:GL478075:36995:38394:-1 ...	[more]
dlx5a	7.999e-13	52.54	distal-less homeobox 5a [Source:NCBI gene;Acc:3056...	[more]
HMX1	1.145e-12	53.45	H6 family homeobox 1 [Source:HGNC Symbol;Acc:HGNC:...	[more]

BLAST of Homeobox protein DTH-1 vs. Ensembl Yeast
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46)
Total hits: 1


Match Name	E-value	Identity	Description
HMRA1	4.834e-6	42.86	Silenced copy of a1 at HMR; homeobox corepressor t...	[more]

BLAST of Homeobox protein DTH-1 vs. Ensembl Nematostella
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46)
Total hits: 5


Match Name	E-value	Identity	Description
EDO33946	1.452e-25	72.31	Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7...	[more]
NK-2	1.679e-23	70.31	Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7...	[more]
EDO33947	2.472e-23	69.84	Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7...	[more]
EDO45871	1.067e-21	62.90	Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7...	[more]
EDO33963	2.688e-20	64.06	Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7...	[more]

BLAST of Homeobox protein DTH-1 vs. Ensembl Medaka
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99)
Total hits: 5


Match Name	E-value	Identity	Description
nkx2.2a	1.388e-31	73.08	homeobox protein Nkx-2.2a [Source:NCBI gene;Acc:10...	[more]
nkx2.2a	1.708e-31	73.08	homeobox protein Nkx-2.2a [Source:NCBI gene;Acc:10...	[more]
nkx2.2a	2.631e-30	80.88	homeobox protein Nkx-2.2a [Source:NCBI gene;Acc:10...	[more]
NKX2-8	2.348e-26	42.65	NK2 homeobox 8 [Source:NCBI gene;Acc:101166096]	[more]
nkx2.1	1.538e-25	73.44	NK2 homeobox 1 [Source:NCBI gene;Acc:100049404]	[more]

BLAST of Homeobox protein DTH-1 vs. Planmine SMEST
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST)
Total hits: 5


Match Name	E-value	Identity	Description
SMESG000079512.1	0.000e+0	92.19	SMESG000079512.1	[more]
SMESG000037282.1	7.284e-27	71.01	SMESG000037282.1	[more]
SMESG000037282.1	8.832e-27	71.01	SMESG000037282.1	[more]
SMESG000081885.1	1.653e-21	71.93	SMESG000081885.1	[more]
SMESG000062916.1	3.690e-21	62.32	SMESG000062916.1	[more]

Analyses

This transcript is derived from or has results from the following analyses


Analysis Name	Date Performed
Embryonic Stages	2016-07-25
Schmidtea mediterranea smed_20140614 BLASTX Human e!99	2016-08-08
Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99	2016-08-08
Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL	2020-05-01
Schmidtea mediterranea Sexual smed_20140614 transcriptome	2016-07-25
Schmidtea mediteranean smed_20140614 Interproscan	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST	2020-05-08

Sequences

The following sequences are available for this feature:

transcript sequence
protein sequence

transcript sequence

>SMED30011793 ID=SMED30011793|Name=Homeobox protein DTH-1|organism=Schmidtea mediterranea sexual|type=transcript|length=1926bp
ATCTGCGATTTGTCAATTCAACAAAAACCCACTTGACCAATAATCATCAT
ATTTGTTATTATTTCAAACAGAAAATTCAACCTCTCCAATTCTGATAACT
CGAAAATCACATTATTCAACCATTTCCAACCTGTTCAGCTCTAAGTGTCC
ACTTAAAGATGAGTTCAAATGGTGACTGTGTCAAGTACGATTCAAATTTT
GATAGAGAAGGATACTCAACCGACACAAGCACAGATTGCCCAATCCAAAC
CGACGATTCTCTACACGAGATTCAAACGTCCTCTCTGCCAGACAGCTTTC
AATTGTTTCCACAAAATACCAAAGCCCACATCAATGAACTCCATGAAACA
TTCTCTGCCGCCAACTCGATTACGCAACATCTTCAAGTCAACAACAACAA
CAACCACATTAACTACAGTAATTCGAATTTAATCCATTCAAACAATCATT
TCATTACGACAGATTCGTCAATTTACCAGAACTTCAATCTAATTCCAAGG
AGTTTCATTTCCAATGACGAACATTCGTCAAATATGTCCTTCGTACAGAT
GCTAAACTCGCCAAATTATGCTCAGATTGATCCAGCATTTTTTCCCAACA
TGCCGGGAATCGGAAACAGTTTCATGATGCAGAGCATTTTGAATCCGAAT
TCCAGTGAACAAGAAATCGAGAATCCGATTTCAAACAGTTCCACTTACGT
TTTGGTGCCAGCAGACTCAAACATCCAGTCGAATCCTCAGTCGAACTCGA
TTAATTCAGCGTACGGATCACTGAATTTGACCAACTGTGGAAACAACCTA
TTCCAATATTCCAGCCAATCTAATCAACACCAATACCCCGATATCAATGG
AAACGGGCCCCGGCTTTTACATTGTAAACACGAAATGCAGTATCCCCCCG
ATAACATCAGTCCATTTGAATATCATTTATCTAAATCGATACAAAATAGC
TCCCCCTCGCCTTACAAATTATCATTACCAGAAATTAAAACAATTTCAAA
TGAGTGGATCAAAGGATCTCCAAACATTATCAACTTCAATCAAAATCAAC
GTTTACGCAACCAAAACGTATCAGATTATTCCAACGTAAAATCTTTACCT
CAAACTCTGCTTAACCAGAACCAAACAGATTCTATTTATTCCTCCTCGAT
AAACGAAAACCGTTTACCAGTTAATAATTTCGATTCTCCAAACGCTGACA
GAGAAGACGACTCAGAAACCCAAGACAACCCGAACCAGAAAGACACAAGT
TCTGTGGAAAATAATGACAACGACAATTCATCTTCGGGTGATGTTGGTAA
AAAACGAAAACGACGAGTGTTATTTAGTAAGAAACAAATTCTGGAACTCG
AGCGGCACTTTCGACAGAAGAAATATCTCTCAGCACCGGAACGGGAACAT
TTAGCAAATCTAATTGGTTTATCGCCAACCCAGGTGAAAATCTGGTTCCA
GAATCACCGATACAAAATGAAACGAGCCCACCATGAAAAGTCTTTGGAAA
TGGGAAATTTAGCGGTGAATCGTCGAATTAGTCAAACAATGTTCAATGAC
TCCAAATCACATATGCCTTCAAATTTTGATTTGGGAATGAATAATTCTTT
CTATAATTCCAATCTCTCATTTGGTAATTTGAGTTTAAATCCCGCTGCTA
ATTTAATGGGACGAATTCCAGGTATGTCTAGTATGATTCCAACATATCAA
AATGGGCCCCAGTCGTATTTCAACAGCATAAATCCCGCCACATTAGCTGG
CTCTAATTCTTCATGGGGTCATTGAATCGAAAACATTCTCGAATCCACAA
CAACTGCTCAGAACCTTCCTTTCCTCGAGTTTCAAAGACACTGGGATACT
TATTAATTATTATGAACTGATCGTATGTTGAGTGAATATTAATAAAAAAG
GTTTTTTATTTAGAAAAAAAAGATCG

protein sequence of SMED30011793-orf-1

>SMED30011793-orf-1 ID=SMED30011793-orf-1|Name=SMED30011793-orf-1|organism=Schmidtea mediterranea sexual|type=polypeptide|length=539bp
MSSNGDCVKYDSNFDREGYSTDTSTDCPIQTDDSLHEIQTSSLPDSFQLF
PQNTKAHINELHETFSAANSITQHLQVNNNNNHINYSNSNLIHSNNHFIT
TDSSIYQNFNLIPRSFISNDEHSSNMSFVQMLNSPNYAQIDPAFFPNMPG
IGNSFMMQSILNPNSSEQEIENPISNSSTYVLVPADSNIQSNPQSNSINS
AYGSLNLTNCGNNLFQYSSQSNQHQYPDINGNGPRLLHCKHEMQYPPDNI
SPFEYHLSKSIQNSSPSPYKLSLPEIKTISNEWIKGSPNIINFNQNQRLR
NQNVSDYSNVKSLPQTLLNQNQTDSIYSSSINENRLPVNNFDSPNADRED
DSETQDNPNQKDTSSVENNDNDNSSSGDVGKKRKRRVLFSKKQILELERH
FRQKKYLSAPEREHLANLIGLSPTQVKIWFQNHRYKMKRAHHEKSLEMGN
LAVNRRISQTMFNDSKSHMPSNFDLGMNNSFYNSNLSFGNLSLNPAANLM
GRIPGMSSMIPTYQNGPQSYFNSINPATLAGSNSSWGH*

Aliases

The feature 'Homeobox protein DTH-1' has the following synonyms


Synonym
nkx2.2

Annotated Terms

The following terms have been associated with this transcript:

Vocabulary: **Planarian Anatomy**
Term	Definition
PLANA:0000026	gut
PLANA:0000039	gamma neoblast
PLANA:0000070	intestinal phagocyte
PLANA:0000421	tail
PLANA:0000429	neoblast
PLANA:0002142	parenchyma

Vocabulary: **INTERPRO**
Term	Definition
IPR001356	Homeobox_dom
IPR009057	Homeobox-like_sf
IPR017970	Homeobox_CS

Vocabulary: **molecular function**
Term	Definition
GO:0003677	DNA binding
GO:0043565	sequence-specific DNA binding

Vocabulary: **biological process**
Term	Definition
GO:0006355	regulation of transcription, DNA-templated
GO:0007275	multicellular organism development

Vocabulary: **cellular component**
Term	Definition
GO:0005634	nucleus

InterPro

Analysis Name: Schmidtea mediteranean smed_20140614 Interproscan
Date Performed: 2020-05-01


IPR Term	IPR Description	Source	Source Term	Source Description	Alignment
IPR001356	Homeobox domain	SMART	SM00389	HOX_1	coord: 381..443 e-value: 3.2E-25 score: 99.8
IPR001356	Homeobox domain	PFAM	PF00046	Homeodomain	coord: 382..438 e-value: 2.9E-20 score: 71.9
IPR001356	Homeobox domain	PROSITE	PS50071	HOMEOBOX_2	coord: 379..439 score: 20.212
IPR001356	Homeobox domain	CDD	cd00086	homeodomain	coord: 382..440 e-value: 2.71922E-22 score: 88.0692
None	No IPR available	GENE3D	G3DSA:1.10.10.60		coord: 342..443 e-value: 1.3E-24 score: 88.1
None	No IPR available	MOBIDB_LITE	mobidb-lite	disorder_prediction	coord: 342..384
None	No IPR available	MOBIDB_LITE	mobidb-lite	disorder_prediction	coord: 357..374
None	No IPR available	PANTHER	PTHR24340:SF24	HOMEOBOX PROTEIN NKX-2.2	coord: 321..457
None	No IPR available	PANTHER	PTHR24340	FAMILY NOT NAMED	coord: 321..457
IPR017970	Homeobox, conserved site	PROSITE	PS00027	HOMEOBOX_1	coord: 414..437
IPR009057	Homeobox-like domain superfamily	SUPERFAMILY	SSF46689	Homeodomain-like	coord: 367..439