Histone-lysine N-methyltransferase, H3 lysine-36 and H4 lysine-20 specific
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Overview
Neoblast Clusters
Zeng et. al., 2018▻ Overview▻ Neoblast Population▻ Sub-lethal Irradiated Surviving X1 and X2 Cell Population
Overview
Single cell RNA-seq of pluripotent neoblasts and its early progeniesWe isolated X1 neoblasts cells enriched in high piwi-1 expression (Neoblast Population), and profiled ∼7,614 individual cells via scRNA-seq. Unsupervised analyses uncovered 12 distinct classes from 7,088 high-quality cells. We designated these classes Nb1 to Nb12 and ordered them based on high (Nb1) to low (Nb12) piwi-1 expression levels. We further defined groups of genes that best classified the cells parsed into 12 distinct cell clusters to generate a scaled expression heat map of discriminative gene sets for each cluster. Expression of each cluster’s gene signatures was validated using multiplex fluorescence in situ hybridization (FISH) co-stained with piwi-1 and largely confirmed the cell clusters revealed by scRNA-seq.We also tested sub-lethal irradiation exposure. To profile rare pluripotent stem cells (PSCs) and avoid interference from immediate progenitor cells, we determined a time point after sub-lethal irradiation (7 DPI) with minimal piwi-1+ cells, followed by isolation and single-cell RNA-seq of 1,200 individual cells derived from X1 (Piwi-1 high) and X2 (Piwi-1 low) cell populations (Sub-lethal Irradiated Surviving X1 and X2 Cell Population)Explore this single cell expression dataset with our NB Cluster Shiny App
Neoblast Population
Sub-lethal Irradiated Surviving X1 and X2 Cell Population
Embryonic Expression
Davies et. al., 2017
Hover the mouse over a column in the graph to view average RPKM values per sample. Embryonic Stages: Y: yolk. S2-S8: Stages 2-8. C4: asexual adult. SX: virgin, sexually mature adult. back to top Anatomical Expression
PAGE et. al., 2020SMED30011787 has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGEPAGE Curations: 4
Homology
BLAST of Histone-lysine N-methyltransferase, H3 lysine-36 and H4 lysine-20 specific vs. Ensembl Human
Match: NSD3 (nuclear receptor binding SET domain protein 3 [Source:HGNC Symbol;Acc:HGNC:12767]) HSP 1 Score: 88.1965 bits (217), Expect = 8.702e-17 Identity = 106/514 (20.62%), Postives = 202/514 (39.30%), Query Frame = 1
Query: 763 CNNHTCMRPYHRLCLSAHLDMSPDMK--QCPLHSCINCALDYLAEPESKRVQSHLDLVSCVKCKLAFHNIIDCLPTTFIRITRHLIICHRHLVPSDLLQSNVAQFCFYCSRSISV--HNPPVSCKYCLVTYH-------------KCLPCLSGATELLDEHTFI--CNACKFPYVHRGQCLALALPRETLTNDSVHSWKLGHLNLVTESTTGNKSVIVTEQTGKKWPTDI--HRTIAINLQSLDH-LVSFGVLRFQDIQYALRDLTKLVERVA--TSYNLCQNFYRNTF---VLRFAGLFPLVENLYYGNASTFMDPNQSRP---------------------LAKPMKCDCLEA-----CTTMKCPNVAANAECTDENCGAQNRCRNRRLQKRNFPRSKLLLVDEIGPYVMIDETVVKDVLVGELVGVVKSTAWAEANFQRIGPSNC----VFKLSNEAVIDCSQFCSIFRFIKTSDRPNLQVKIVTVAGFRRIGLFSSHRIVKGDILTLDFD 2133
C+ C + YH C+ + K +CP H C C+++ SK ++ C++C +A+H+ C+ + ++ +++IC H S + FCF C+R + V H+ P+ Y +++ +P S + + ++ + C +C P +CL++ +P + + K H + GN + WP +I R++ +N+Q L H L F V F Y ++ V S+ Q TF + A F ++ + ++ N +P L++ +C+C A +C N EC + C A +RC+N+ KR +P ++++ + G + ++ K V E VG + +R ++ + ++ + +ID + RF+ S PN + + TV G R+GLF+ I G LT +++
Sbjct: 765 CSVGACGKFYHEACVRKFPTAIFESKGFRCPQHCCSACSMEKDIHKASKG-----RMMRCLRCPVAYHSGDACIAAGSMLVSSYILICSNHSKRSSNSSAVNVGFCFVCARGLIVQDHSDPMFSSYAYKSHYLLNESNRAELMKLPMIPSSSASKKKCEKGGRLLCCESC--PASFHPECLSIEMPEGCWNCNDCKAGKKLHYKQIVWVKLGNY---------RWWPAEICNPRSVPLNIQGLKHDLGDFPVFFFGSHDYYWVHQGRVFPYVEGDKSFAEGQTSINKTFKKALEEAAKRFQELKAQRESKEALEIEKNSRKPPPYKHIKANKVIGKVQIQVADLSEIPRCNCKPADENPCGLESECLNRMLQYECHPQVCPAGDRCQNQCFTKRLYPDAEIIKTERRGWGLRTKRSIKKGEFVNEYVGELIDEEECRLRIKRAHENSVTNFYMLTVTKDRIIDAGPKGNYSRFMNHSCNPNCETQKWTVNGDVRVGLFALCDIPAGMELTFNYN 1262
BLAST of Histone-lysine N-methyltransferase, H3 lysine-36 and H4 lysine-20 specific vs. Ensembl Human
Match: NSD3 (nuclear receptor binding SET domain protein 3 [Source:HGNC Symbol;Acc:HGNC:12767]) HSP 1 Score: 86.6557 bits (213), Expect = 2.863e-16 Identity = 107/515 (20.78%), Postives = 201/515 (39.03%), Query Frame = 1
Query: 763 CNNHTCMRPYHRLCLSAHLDMSPDMK--QCPLHSCINCALDYLAEPESKRVQSHLDLVSCVKCKLAFHNIIDCLPTTFIRITRHLIICHRHLVPSDLLQSNVAQFCFYCSRSISV--HNPPVSCKYCLVTYH-------------KCLPCLSGATELLDEHTFI--CNACKFPYVHRGQCLALALPRETLTNDSVHSWKLGHLNLVTESTTGNKSVIVTEQTGKKWPTDI--HRTIAINLQSLDH-LVSFGVLRFQDIQYALRDLTKLVERVA--TSYNLCQNFYRNTF---VLRFAGLFPLVENLYYGNASTFMDPNQSRP---------------------LAKPMKCDCLEA-----CTTMKCPNVAANAECTDENCGAQNRCRNRRLQKRNFPRSKLLLVDEIGPYVMIDETVVKDVLVGELVGVVKSTAWAEANFQRIGPSNCVFKL-----SNEAVIDCSQFCSIFRFIKTSDRPNLQVKIVTVAGFRRIGLFSSHRIVKGDILTLDFD 2133
C+ C + YH C+ + K +CP H C C+++ SK ++ C++C +A+H+ C+ + ++ +++IC H S + FCF C+R + V H+ P+ Y +++ +P S + + ++ + C +C P +CL++ +P + + K H + GN + WP +I R++ +N+Q L H L F V F Y ++ V S+ Q TF + A F ++ + ++ N +P L++ +C+C A +C N EC + C A +RC+N+ KR +P ++++ + G + ++ K V E VG + I C ++ +++ +ID + RF+ S PN + + TV G R+GLF+ I G LT +++
Sbjct: 765 CSVGACGKFYHEACVRKFPTAIFESKGFRCPQHCCSACSMEKDIHKASKG-----RMMRCLRCPVAYHSGDACIAAGSMLVSSYILICSNHSKRSSNSSAVNVGFCFVCARGLIVQDHSDPMFSSYAYKSHYLLNESNRAELMKLPMIPSSSASKKKCEKGGRLLCCESC--PASFHPECLSIEMPEGCWNCNDCKAGKKLHYKQIVWVKLGNY---------RWWPAEICNPRSVPLNIQGLKHDLGDFPVFFFGSHDYYWVHQGRVFPYVEGDKSFAEGQTSINKTFKKALEEAAKRFQELKAQRESKEALEIEKNSRKPPPYKHIKANKVIGKVQIQVADLSEIPRCNCKPADENPCGLESECLNRMLQYECHPQVCPAGDRCQNQCFTKRLYPDAEIIKTERRGWGLRTKRSIKKGEFVNEYVGEL------------IDEEECRLRIKRAHENSDRIIDAGPKGNYSRFMNHSCNPNCETQKWTVNGDVRVGLFALCDIPAGMELTFNYN 1251
BLAST of Histone-lysine N-methyltransferase, H3 lysine-36 and H4 lysine-20 specific vs. Ensembl Human
Match: NSD3 (nuclear receptor binding SET domain protein 3 [Source:HGNC Symbol;Acc:HGNC:12767]) HSP 1 Score: 80.8777 bits (198), Expect = 1.358e-14 Identity = 100/497 (20.12%), Postives = 188/497 (37.83%), Query Frame = 1
Query: 763 CNNHTCMRPYHRLCLSAHLDMSPDMK--QCPLHSCINCALDYLAEPESKRVQSHLDLVSCVKCKLAFHNIIDCLPTTFIRITRHLIICHRHLVPSDLLQSNVAQFCFYCSRSISVHNPPVSCKYCLVTYHKCLPCLSGATELLDEHTFICNACKFPYVHRGQCLALALPRETLTNDSVHSWKLGHLNLVTESTTGNKSVIVTEQTGKKWPTDI--HRTIAINLQSLDH-LVSFGVLRFQDIQYALRDLTKLVERVA--TSYNLCQNFYRNTF---VLRFAGLFPLVENLYYGNASTFMDPNQSRP---------------------LAKPMKCDCLEA-----CTTMKCPNVAANAECTDENCGAQNRCRNRRLQKRNFPRSKLLLVDEIGPYVMIDETVVKDVLVGELVGVVKSTAWAEANFQRIGPSNC----VFKLSNEAVIDCSQFCSIFRFIKTSDRPNLQVKIVTVAGFRRIGLFSSHRIVKGDILTLDFD 2133
C+ C + YH C+ + K +CP H C C+++ SK ++ C++C +A+H+ C+ + ++ +++IC H S + FCF C+R + + C+ C ++H +CL++ +P + + K H + GN + WP +I R++ +N+Q L H L F V F Y ++ V S+ Q TF + A F ++ + ++ N +P L++ +C+C A +C N EC + C A +RC+N+ KR +P ++++ + G + ++ K V E VG + +R ++ + ++ + +ID + RF+ S PN + + TV G R+GLF+ I G LT +++
Sbjct: 765 CSVGACGKFYHEACVRKFPTAIFESKGFRCPQHCCSACSMEKDIHKASKG-----RMMRCLRCPVAYHSGDACIAAGSMLVSSYILICSNHSKRSSNSSAVNVGFCFVCARGGRL----LCCESCPASFHP------------------------------ECLSIEMPEGCWNCNDCKAGKKLHYKQIVWVKLGNY---------RWWPAEICNPRSVPLNIQGLKHDLGDFPVFFFGSHDYYWVHQGRVFPYVEGDKSFAEGQTSINKTFKKALEEAAKRFQELKAQRESKEALEIEKNSRKPPPYKHIKANKVIGKVQIQVADLSEIPRCNCKPADENPCGLESECLNRMLQYECHPQVCPAGDRCQNQCFTKRLYPDAEIIKTERRGWGLRTKRSIKKGEFVNEYVGELIDEEECRLRIKRAHENSVTNFYMLTVTKDRIIDAGPKGNYSRFMNHSCNPNCETQKWTVNGDVRVGLFALCDIPAGMELTFNYN 1213
BLAST of Histone-lysine N-methyltransferase, H3 lysine-36 and H4 lysine-20 specific vs. Ensembl Human
Match: NSD2 (nuclear receptor binding SET domain protein 2 [Source:HGNC Symbol;Acc:HGNC:12766]) HSP 1 Score: 75.0998 bits (183), Expect = 6.827e-13 Identity = 100/490 (20.41%), Postives = 176/490 (35.92%), Query Frame = 1
Query: 778 CMRPYHRLCLSAHLDMSPDMK--QCPLHSCINCALDYLAEPESKRVQSHLDLVSCVKCKLAFHNIIDCLPTTFIRITRHLIICHRHLVPSDLLQSNVAQFCFYCSRSISVHNPPVSCKYCLVTYHKCLPCLSGATELLDEHTFICNACKFPYVHRGQCLALALPRETLTNDSVHSWKLGHLNLVTESTTGNKSVIVTEQTGKKWPTDI--HRTIAINLQSLDHLVS-FGVLRFQDIQYALRDLTKLVERV----ATSYNLCQNFYR------NTFVLRFAGLFPLVENLYYGNASTFMDPNQSRPLAKPM--------------KCDCLEA-----CTTMKCPNVAANAECTDENCGAQNRCRNRRLQKRNFPRSKLLLVDEIGPYVMIDETVVKDVLVGELVGVVKSTAWAEANFQRIGPSNC----VFKLSNEAVIDCSQFCSIFRFIKTSDRPNLQVKIVTVAGFRRIGLFSSHRIVKGDILTLDFD 2133
C + YH C+ + + + +CPLHSC++C + P + + ++ CV+C +A+H+ CL I + IIC H +R H+ V+ +C V C G + L C +C P CL + +P + + + K H + GN + WP ++ + + N+Q + H + F V F Y ++ + + Y + R RF + E + P + + KP KC+C +C N EC + C A C+N+ KR +P +K++ D G ++ + K V E VG + A + ++ + + + +ID + RF+ S +PN + TV G R+GLF+ I G LT +++
Sbjct: 83 CGKFYHEACVKKYPLTVFESRGFRCPLHSCVSCHASNPSNPRPSKGK----MMRCVRCPVAYHSGDACLAAGCSVIASNSIICTAHFT----------------ARKGKRHHAHVNVSWCFV-------CSKGGSLL------CCESC--PAAFHPDCLNIEMPDGSWFCNDCRAGKKLHFQDIIWVKLGNY---------RWWPAEVCHPKNVPPNIQKMKHEIGEFPVFFFGSKDYYWTHQARVFPYMEGDRGSRYQGVRGIGRVFKNALQEAEARFREIKLQREARETQESERKPPPYKHIKVNKPYGKVQIYTADISEIPKCNCKPTDENPCGFDSECLNRMLMFECHPQVCPAGEFCQNQCFTKRQYPETKIIKTDGKGWGLVAKRDIRKGEFVNEYVGELIDEEECMARIKHAHENDITHFYMLTIDKDRIIDAGPKGNYSRFMNHSCQPNCETLKWTVNGDTRVGLFAVCDIPAGTELTFNYN 528
BLAST of Histone-lysine N-methyltransferase, H3 lysine-36 and H4 lysine-20 specific vs. Ensembl Human
Match: NSD2 (nuclear receptor binding SET domain protein 2 [Source:HGNC Symbol;Acc:HGNC:12766]) HSP 1 Score: 74.3294 bits (181), Expect = 1.360e-12 Identity = 114/545 (20.92%), Postives = 198/545 (36.33%), Query Frame = 1
Query: 628 CGSYCSWKYHKDCV----KDENDLVCS-CNKSVWLCSICCEVINVSQLFVCNNHTCMRPYHRLCLSAHLDMSPDMK--QCPLHSCINCALDYLAEPESKRVQSHLDLVSCVKCKLAFHNIIDCLPTTFIRITRHLIICHRHLVPSDLLQSNVAQFCFYCSRSISVHNPPVSCKYCLVTYHKCLPCLSGATELLDEHTFICNACKFPYVHRGQCLALALPRETLTNDSVHSWKLGHLNLVTESTTGNKSVIVTEQTGKKWPTDI--HRTIAINLQSLDHLVS-FGVLRFQDIQY----ALRDLTKLVERVATSYNLCQNFYRNTFVLRFAGLFPLVENLYYGNASTFMDPNQSRPLAKPMKCDCLEACTTMKCPNVAANAEC----TDEN-CGAQNRCRNRRLQ--------------------KRNFPRSKLLLVDEIGPYVMIDETVVKDVLVGELVGVVKSTAWAEANFQRIGPSNC----VFKLSNEAVIDCSQFCSIFRFIKTSDRPNLQVKIVTVAGFRRIGLFSSHRIVKGDILTLDFD 2133
C C +H C+ + E CS C + C +C E + + + C C + YH C+ + + + +CPLHSC++C + + P + R S ++ CV+C +A+H+ CL I + IIC H + +R H+ V+ +C V C G + L C +C P CL + +P + + + K H + GN + WP ++ + + N+Q + H + F V F Y R + + Y + R E A + + P K +K + + +++ +C TDEN CG + C NR L KR +P +K++ D G ++ + K V E VG + A + ++ + + + +ID + RF+ S +PN + TV G R+GLF+ I G LT +++
Sbjct: 682 CEGPCCGAFHLACLGLSRRPEGRFTCSECASGIHSCFVCKE--SKTDVKRCVVTQCGKFYHEACVKKYPLTVFESRGFRCPLHSCVSC---HASNPSNPR-PSKGKMMRCVRCPVAYHSGDACLAAGCSVIASNSIICTAH----------------FTARKGKRHHAHVNVSWCFV-------CSKGGSLL------CCESC--PAAFHPDCLNIEMPDGSWFCNDCRAGKKLHFQDIIWVKLGNY---------RWWPAEVCHPKNVPPNIQKMKHEIGEFPVFFFGSKDYYWTHQARVFPYMEGDRGSRYQGVRGIGRVFKNALQEAEARFREIKLQREARETQESERKPPPYKHIKVNKPYGKVQIYTADISEIPKCNCKPTDENPCGFDSECLNRMLMFECHPQVCPAGEFCQNQCFTKRQYPETKIIKTDGKGWGLVAKRDIRKGEFVNEYVGELIDEEECMARIKHAHENDITHFYMLTIDKDRIIDAGPKGNYSRFMNHSCQPNCETLKWTVNGDTRVGLFAVCDIPAGTELTFNYN 1180
BLAST of Histone-lysine N-methyltransferase, H3 lysine-36 and H4 lysine-20 specific vs. Ensembl Celegans
Match: set-12 (Histone-lysine N-methyltransferase [Source:UniProtKB/TrEMBL;Acc:Q21404]) HSP 1 Score: 56.6102 bits (135), Expect = 7.269e-8 Identity = 53/194 (27.32%), Postives = 80/194 (41.24%), Query Frame = 1
Query: 1576 LFPLVENLYYGNASTFMDPNQSRPLAKPMKCDCLEACTTMKCPNVAANAECTDENCGAQNRCRNRRLQKRNFPRSKLLLVDE-IGPYVMIDETVVKDVLVGELVGVVKSTAWAEANFQRIGPSNC----VFKLSNEAVIDCSQFCSIFRFIKTSDRPNLQVKIVTVAG--FRRIGLFSSHRIVKGDILTLDFDS 2136
FP + Y S P + L C C CTT +C N A + EC G N C N+R +KR F + L D IG + E + L+ E G + A +R F++ +D ++ + RFI S PN VK+ TV + +G+F+S I G+ +T D+ +
Sbjct: 30 FFPNTRRMDY---SFICSPKRKTGLLTVTSCKCGTDCTTEECSNFANHRECPR---GCSN-CENQRFRKRQFCGVETFLTDNGIGHGLRATEEIATGKLILEYRGEAITKAEHNKRVKRYKKDGIKHSYSFEVGRNYYVDPTRKGNSARFINHSCNPNALVKVWTVPDRPMKSLGIFASKVIKPGEEITFDYGT 216
BLAST of Histone-lysine N-methyltransferase, H3 lysine-36 and H4 lysine-20 specific vs. Ensembl Celegans
Match: set-2 (Histone-lysine N-methyltransferase set-2 [Source:UniProtKB/Swiss-Prot;Acc:Q18221]) HSP 1 Score: 51.6026 bits (122), Expect = 4.290e-6 Identity = 33/106 (31.13%), Postives = 58/106 (54.72%), Query Frame = 1
Query: 1825 GPYVMIDETVVKDVLVGELVGVVKSTAWAEAN---FQRIG-PSNCVFKLSNEAVIDCSQFCSIFRFIKTSDRPNLQVKIVTVAGFRRIGLFSSHRIVKGDILTLDF 2130
G Y M E++ D ++ E +G + AE ++R G S+ +F++ VID ++ + RFI S +PN K++T+ G +RI ++S I KG+ +T D+
Sbjct: 1381 GLYAM--ESIAPDEMIVEYIGQTIRSLVAEEREKAYERRGIGSSYLFRIDLHHVIDATKRGNFARFINHSCQPNCYAKVLTIEGEKRIVIYSRTIIKKGEEITYDY 1484
BLAST of Histone-lysine N-methyltransferase, H3 lysine-36 and H4 lysine-20 specific vs. Ensembl Celegans
Match: set-2 (Histone-lysine N-methyltransferase set-2 [Source:UniProtKB/Swiss-Prot;Acc:Q18221]) HSP 1 Score: 51.6026 bits (122), Expect = 4.364e-6 Identity = 33/106 (31.13%), Postives = 58/106 (54.72%), Query Frame = 1
Query: 1825 GPYVMIDETVVKDVLVGELVGVVKSTAWAEAN---FQRIG-PSNCVFKLSNEAVIDCSQFCSIFRFIKTSDRPNLQVKIVTVAGFRRIGLFSSHRIVKGDILTLDF 2130
G Y M E++ D ++ E +G + AE ++R G S+ +F++ VID ++ + RFI S +PN K++T+ G +RI ++S I KG+ +T D+
Sbjct: 1384 GLYAM--ESIAPDEMIVEYIGQTIRSLVAEEREKAYERRGIGSSYLFRIDLHHVIDATKRGNFARFINHSCQPNCYAKVLTIEGEKRIVIYSRTIIKKGEEITYDY 1487
BLAST of Histone-lysine N-methyltransferase, H3 lysine-36 and H4 lysine-20 specific vs. Ensembl Celegans
Match: set-2 (Histone-lysine N-methyltransferase set-2 [Source:UniProtKB/Swiss-Prot;Acc:Q18221]) HSP 1 Score: 51.2174 bits (121), Expect = 5.281e-6 Identity = 39/123 (31.71%), Postives = 64/123 (52.03%), Query Frame = 1
Query: 1825 GPYVMIDETVVKDVLVGELVGVVKSTAWAEAN---FQRIG-PSNCVFKLSNEAVIDCSQFCSIFRFIKTSDRPNLQVKIVTVAGFRRIGLFSSHRIVKGDILTLDFDSLIYRVARD-SCGAPT 2178
G Y M E++ D ++ E +G + AE ++R G S+ +F++ VID ++ + RFI S +PN K++T+ G +RI ++S I KG+ +T D+ I D CGA T
Sbjct: 613 GLYAM--ESIAPDEMIVEYIGQTIRSLVAEEREKAYERRGIGSSYLFRIDLHHVIDATKRGNFARFINHSCQPNCYAKVLTIEGEKRIVIYSRTIIKKGEEITYDYKFPIEDDKIDCLCGAKT 733
BLAST of Histone-lysine N-methyltransferase, H3 lysine-36 and H4 lysine-20 specific vs. Ensembl Fly
Match: E(z) (gene:FBgn0000629 transcript:FBtr0334067) HSP 1 Score: 58.5362 bits (140), Expect = 3.849e-8 Identity = 48/172 (27.91%), Postives = 72/172 (41.86%), Query Frame = 1
Query: 1666 CDCLEACTTMKCPNVAANAECTDENCGA-------------QNRCRNRRLQKRNFPRSKLLLV--DEIGPYVMIDETVVKDVLVGELVGVVKSTAWAEANFQRIGPSNC--VFKLSNEAVIDCSQFCSIFRFIKTSDRPNLQVKIVTVAGFRRIGLFSSHRIVKGDILTLDF 2130
C C C T +CP A EC + C A +N C R L K LL+ D G + + E K+ + E G + S A+ + C +F L+N+ V+D ++ + RF S PN K++ V G RIG+F+ I G+ L D+
Sbjct: 580 CRCKAQCNTKQCPCYLAVRECDPDLCQACGADQFKLTKITCKNVCVQRGLHKH------LLMAPSDIAGWGIFLKEGAQKNEFISEYCGEIISQDEADRRGKVYDKYMCSFLFNLNNDFVVDATRKGNKIRFANHSINPNCYAKVMMVTGDHRIGIFAKRAIQPGEELFFDY 745
BLAST of Histone-lysine N-methyltransferase, H3 lysine-36 and H4 lysine-20 specific vs. Ensembl Fly
Match: E(z) (gene:FBgn0000629 transcript:FBtr0273338) HSP 1 Score: 58.5362 bits (140), Expect = 4.109e-8 Identity = 48/172 (27.91%), Postives = 72/172 (41.86%), Query Frame = 1
Query: 1666 CDCLEACTTMKCPNVAANAECTDENCGA-------------QNRCRNRRLQKRNFPRSKLLLV--DEIGPYVMIDETVVKDVLVGELVGVVKSTAWAEANFQRIGPSNC--VFKLSNEAVIDCSQFCSIFRFIKTSDRPNLQVKIVTVAGFRRIGLFSSHRIVKGDILTLDF 2130
C C C T +CP A EC + C A +N C R L K LL+ D G + + E K+ + E G + S A+ + C +F L+N+ V+D ++ + RF S PN K++ V G RIG+F+ I G+ L D+
Sbjct: 575 CRCKAQCNTKQCPCYLAVRECDPDLCQACGADQFKLTKITCKNVCVQRGLHKH------LLMAPSDIAGWGIFLKEGAQKNEFISEYCGEIISQDEADRRGKVYDKYMCSFLFNLNNDFVVDATRKGNKIRFANHSINPNCYAKVMMVTGDHRIGIFAKRAIQPGEELFFDY 740
BLAST of Histone-lysine N-methyltransferase, H3 lysine-36 and H4 lysine-20 specific vs. Ensembl Fly
Match: E(z) (gene:FBgn0000629 transcript:FBtr0076279) HSP 1 Score: 58.5362 bits (140), Expect = 4.109e-8 Identity = 48/172 (27.91%), Postives = 72/172 (41.86%), Query Frame = 1
Query: 1666 CDCLEACTTMKCPNVAANAECTDENCGA-------------QNRCRNRRLQKRNFPRSKLLLV--DEIGPYVMIDETVVKDVLVGELVGVVKSTAWAEANFQRIGPSNC--VFKLSNEAVIDCSQFCSIFRFIKTSDRPNLQVKIVTVAGFRRIGLFSSHRIVKGDILTLDF 2130
C C C T +CP A EC + C A +N C R L K LL+ D G + + E K+ + E G + S A+ + C +F L+N+ V+D ++ + RF S PN K++ V G RIG+F+ I G+ L D+
Sbjct: 575 CRCKAQCNTKQCPCYLAVRECDPDLCQACGADQFKLTKITCKNVCVQRGLHKH------LLMAPSDIAGWGIFLKEGAQKNEFISEYCGEIISQDEADRRGKVYDKYMCSFLFNLNNDFVVDATRKGNKIRFANHSINPNCYAKVMMVTGDHRIGIFAKRAIQPGEELFFDY 740
BLAST of Histone-lysine N-methyltransferase, H3 lysine-36 and H4 lysine-20 specific vs. Ensembl Fly
Match: Set2 (gene:FBgn0030486 transcript:FBtr0073779) HSP 1 Score: 51.9878 bits (123), Expect = 5.284e-6 Identity = 57/219 (26.03%), Postives = 86/219 (39.27%), Query Frame = 1
Query: 1549 NTFVLRFAGL--FPLVENLYYGNASTFMDPNQSRPLAKPMKCDCLEACTTMKCPNVAANAECTDEN--------CGAQNRCRNRRLQKRNFPRSKLLLVDEIGPYVMIDETVVKDVLVGELVG-VVKSTAWAEANFQRIGPSN---CVFKLSNEAVIDCSQFCSIFRFIKTSDRPNLQVKIVTVAGFRRIGLFSSHRIVKGDILTLDFDSLIYRVARDS 2163
N LR GL F L++ +Y A N M+CDC +++ A C + C RC N+R Q+ ++ ++ G + + + + E VG V+ S + N L EAVID + +I R+I S PN + + TV G RIG FS I G+ +T D+ L R RD+
Sbjct: 1326 NEQFLRSEGLNTFQLLKENFYRCARQVSQENAE------MQCDCFLTGDEEAQGHLSCGAGCINRMLMIECGPLCSNGARCTNKRFQQHQCWPCRVFRTEKKGCGITAELLIPPGEFIMEYVGEVIDSEEFERRQHLYSKDRNRHYYFMALRGEAVIDATSKGNISRYINHSCDPNAETQKWTVNGELRIGFFSVKPIQPGEEITFDYQYL--RYGRDA 1536
BLAST of Histone-lysine N-methyltransferase, H3 lysine-36 and H4 lysine-20 specific vs. Ensembl Fly
Match: Set2 (gene:FBgn0030486 transcript:FBtr0301559) HSP 1 Score: 51.6026 bits (122), Expect = 5.689e-6 Identity = 57/219 (26.03%), Postives = 86/219 (39.27%), Query Frame = 1
Query: 1549 NTFVLRFAGL--FPLVENLYYGNASTFMDPNQSRPLAKPMKCDCLEACTTMKCPNVAANAECTDEN--------CGAQNRCRNRRLQKRNFPRSKLLLVDEIGPYVMIDETVVKDVLVGELVG-VVKSTAWAEANFQRIGPSN---CVFKLSNEAVIDCSQFCSIFRFIKTSDRPNLQVKIVTVAGFRRIGLFSSHRIVKGDILTLDFDSLIYRVARDS 2163
N LR GL F L++ +Y A N M+CDC +++ A C + C RC N+R Q+ ++ ++ G + + + + E VG V+ S + N L EAVID + +I R+I S PN + + TV G RIG FS I G+ +T D+ L R RD+
Sbjct: 1277 NEQFLRSEGLNTFQLLKENFYRCARQVSQENAE------MQCDCFLTGDEEAQGHLSCGAGCINRMLMIECGPLCSNGARCTNKRFQQHQCWPCRVFRTEKKGCGITAELLIPPGEFIMEYVGEVIDSEEFERRQHLYSKDRNRHYYFMALRGEAVIDATSKGNISRYINHSCDPNAETQKWTVNGELRIGFFSVKPIQPGEEITFDYQYL--RYGRDA 1487
BLAST of Histone-lysine N-methyltransferase, H3 lysine-36 and H4 lysine-20 specific vs. Ensembl Zebrafish
Match: nsd3 (nuclear receptor binding SET domain protein 3 [Source:ZFIN;Acc:ZDB-GENE-050324-2]) HSP 1 Score: 102.449 bits (254), Expect = 2.244e-21 Identity = 131/561 (23.35%), Postives = 211/561 (37.61%), Query Frame = 1
Query: 628 CGSYCSWKYHKDCVKD----ENDLVCS-CNKSVWLCSICCEVINVSQLFVCNNHTCMRPYHRLCLSAHLDMSPDMK--QCPLHSCINCALDYLAEPESKRVQSHLDLVSCVKCKLAFHNIIDCLPTTFIRITRHLIICHRHLVPSDLLQSNVAQFCFYCSRSISVHNPPVSCKYCLVTYHKCLPCLSGATELLDEHTFICNACKFPYVHRGQCLALALPRETLTNDSVHSWKLGHLNLVTESTTGNKSVIVTEQTGKKWPTDI--HRTIAINLQSLDHLVS-FGVLRFQDIQYALRDLTKLVERVATSYNLCQN--FYRNTF---VLRFAGLFPLVENLYYGNASTFMDPNQSRP---------------------LAKPMKCDCL----EACTT-MKCPNVAANAECTDENCGAQNRCRNRRLQKRNFPRSKLLLVDEIGPYVMIDETVVKDVLVGELVGVVKSTAWAEANFQRIGPSN-------CVFKLSNEAVIDCSQFCSIFRFIKTSDRPNLQVKIVTVAGFRRIGLFSSHRIVKGDILTLDFDSLIYRVARDSC 2166
C C+ +H +C+ E++ VC C C C + + C+ + C R YH C+ + + D K +CP HSC C LD + K ++ C++C +A+H C+ + IT H+IIC H SR + PV+ +C + + LL C AC P +CL + +P T S K H + GN + WP +I R + N+QSL H + F V F Y + ++ V + N + TF + A F ++ + + N RP L++ +C+C C+ +C N EC + C A +RC N+ KR +P ++++ G + + + K V E VG + + E QRI +N + L+ + VID ++ RF+ S PN + + TV G RIGLF+ I LT +++ R SC
Sbjct: 827 CEGDCNRLFHPECMGSNSGKESETVCQECKTGSHPCFSC--KVTEGDMKRCSVNGCGRYYHETCVRKYTGSASDTKGLRCPQHSCATCCLDRDLQKAGKG-----RMMRCIRCPVAYHTGDGCVAAGSVLITPHIIICSNH----------------SSSRKNGHFSSPVNVGWCFICARATKKNIGKGGRLL-----CCEAC--PASFHPECLKIEMPEGTWLCGECKSGKKPHYKQIVWVKLGNY---------RWWPAEICNPRLVPSNIQSLKHDIGDFPVFFFGSHDYYWINQGRVFPYVESDKNFAEGQVGINKTFKKALEEAAKRFQELKAQRETKEALEQERNSRRPPPYKLIKSNKPFGKVQLHVADLSEIPRCNCKPTDERPCSQDSQCLNRMLQYECHPQVCPAGDRCHNQCFSKRLYPDTEVIKTTGRGWGLKTKQDLKKGDFVMEYVGELIDS---EECKQRIRTANENHVTNFYMLTLTKDRVIDAGPKGNLSRFMNHSCSPNCETQKWTVNGDVRIGLFTLCDISADTELTFNYNLDCLGNGRTSC 1345
BLAST of Histone-lysine N-methyltransferase, H3 lysine-36 and H4 lysine-20 specific vs. Ensembl Zebrafish
Match: nsd3 (nuclear receptor binding SET domain protein 3 [Source:ZFIN;Acc:ZDB-GENE-050324-2]) HSP 1 Score: 102.449 bits (254), Expect = 2.457e-21 Identity = 132/561 (23.53%), Postives = 211/561 (37.61%), Query Frame = 1
Query: 628 CGSYCSWKYHKDCVKD----ENDLVCS-CNKSVWLCSICCEVINVSQLFVCNNHTCMRPYHRLCLSAHLDMSPDMK--QCPLHSCINCALDYLAEPESKRVQSHLDLVSCVKCKLAFHNIIDCLPTTFIRITRHLIICHRHLVPSDLLQSNVAQFCFYCSRSISVHNPPVSCKYCLVTYHKCLPCLSGATELLDEHTFICNACKFPYVHRGQCLALALPRETLTNDSVHSWKLGHLNLVTESTTGNKSVIVTEQTGKKWPTDI--HRTIAINLQSLDHLVS-FGVLRFQDIQYALRDLTKLVERVATSYNLCQN--FYRNTF---VLRFAGLFPLVENLYYGNASTFMDPNQSRP---------------------LAKPMKCDCL----EACTT-MKCPNVAANAECTDENCGAQNRCRNRRLQKRNFPRSKLLLVDEIGPYVMIDETVVKDVLVGELVGVVKSTAWAEANFQRIGPSN-------CVFKLSNEAVIDCSQFCSIFRFIKTSDRPNLQVKIVTVAGFRRIGLFSSHRIVKGDILTLDFDSLIYRVARDSC 2166
C C+ +H +C+ E++ VC C C C + + C+ + C R YH C+ + + D K +CP HSC C LD + K ++ C++C +A+H C+ + IT H+IIC H SR + PV+ +C + C G L C AC P +CL + +P T S K H + GN + WP +I R + N+QSL H + F V F Y + ++ V + N + TF + A F ++ + + N RP L++ +C+C C+ +C N EC + C A +RC N+ KR +P ++++ G + + + K V E VG + + E QRI +N + L+ + VID ++ RF+ S PN + + TV G RIGLF+ I LT +++ R SC
Sbjct: 863 CEGDCNRLFHPECMGSNSGKESETVCQECKTGSHPCFSC--KVTEGDMKRCSVNGCGRYYHETCVRKYTGSASDTKGLRCPQHSCATCCLDRDLQKAGKG-----RMMRCIRCPVAYHTGDGCVAAGSVLITPHIIICSNH----------------SSSRKNGHFSSPVNVGWCFI-------CARGGRLL------CCEAC--PASFHPECLKIEMPEGTWLCGECKSGKKPHYKQIVWVKLGNY---------RWWPAEICNPRLVPSNIQSLKHDIGDFPVFFFGSHDYYWINQGRVFPYVESDKNFAEGQVGINKTFKKALEEAAKRFQELKAQRETKEALEQERNSRRPPPYKLIKSNKPFGKVQLHVADLSEIPRCNCKPTDERPCSQDSQCLNRMLQYECHPQVCPAGDRCHNQCFSKRLYPDTEVIKTTGRGWGLKTKQDLKKGDFVMEYVGELIDS---EECKQRIRTANENHVTNFYMLTLTKDRVIDAGPKGNLSRFMNHSCSPNCETQKWTVNGDVRIGLFTLCDISADTELTFNYNLDCLGNGRTSC 1373
BLAST of Histone-lysine N-methyltransferase, H3 lysine-36 and H4 lysine-20 specific vs. Ensembl Zebrafish
Match: nsd3 (nuclear receptor binding SET domain protein 3 [Source:ZFIN;Acc:ZDB-GENE-050324-2]) HSP 1 Score: 102.449 bits (254), Expect = 2.561e-21 Identity = 132/561 (23.53%), Postives = 211/561 (37.61%), Query Frame = 1
Query: 628 CGSYCSWKYHKDCVKD----ENDLVC-SCNKSVWLCSICCEVINVSQLFVCNNHTCMRPYHRLCLSAHLDMSPDMK--QCPLHSCINCALDYLAEPESKRVQSHLDLVSCVKCKLAFHNIIDCLPTTFIRITRHLIICHRHLVPSDLLQSNVAQFCFYCSRSISVHNPPVSCKYCLVTYHKCLPCLSGATELLDEHTFICNACKFPYVHRGQCLALALPRETLTNDSVHSWKLGHLNLVTESTTGNKSVIVTEQTGKKWPTDI--HRTIAINLQSLDHLVS-FGVLRFQDIQYALRDLTKLVERVATSYNLCQN--FYRNTF---VLRFAGLFPLVENLYYGNASTFMDPNQSRP---------------------LAKPMKCDCL----EACTT-MKCPNVAANAECTDENCGAQNRCRNRRLQKRNFPRSKLLLVDEIGPYVMIDETVVKDVLVGELVGVVKSTAWAEANFQRIGPSN-------CVFKLSNEAVIDCSQFCSIFRFIKTSDRPNLQVKIVTVAGFRRIGLFSSHRIVKGDILTLDFDSLIYRVARDSC 2166
C C+ +H +C+ E++ VC C C C + + C+ + C R YH C+ + + D K +CP HSC C LD + K ++ C++C +A+H C+ + IT H+IIC H SR + PV+ +C + C G L C AC P +CL + +P T S K H + GN + WP +I R + N+QSL H + F V F Y + ++ V + N + TF + A F ++ + + N RP L++ +C+C C+ +C N EC + C A +RC N+ KR +P ++++ G + + + K V E VG + + E QRI +N + L+ + VID ++ RF+ S PN + + TV G RIGLF+ I LT +++ R SC
Sbjct: 827 CEGDCNRLFHPECMGSNSGKESETVCQECKTGSHPCFSC--KVTEGDMKRCSVNGCGRYYHETCVRKYTGSASDTKGLRCPQHSCATCCLDRDLQKAGKG-----RMMRCIRCPVAYHTGDGCVAAGSVLITPHIIICSNH----------------SSSRKNGHFSSPVNVGWCFI-------CARGGRLL------CCEAC--PASFHPECLKIEMPEGTWLCGECKSGKKPHYKQIVWVKLGNY---------RWWPAEICNPRLVPSNIQSLKHDIGDFPVFFFGSHDYYWINQGRVFPYVESDKNFAEGQVGINKTFKKALEEAAKRFQELKAQRETKEALEQERNSRRPPPYKLIKSNKPFGKVQLHVADLSEIPRCNCKPTDERPCSQDSQCLNRMLQYECHPQVCPAGDRCHNQCFSKRLYPDTEVIKTTGRGWGLKTKQDLKKGDFVMEYVGELIDS---EECKQRIRTANENHVTNFYMLTLTKDRVIDAGPKGNLSRFMNHSCSPNCETQKWTVNGDVRIGLFTLCDISADTELTFNYNLDCLGNGRTSC 1337
BLAST of Histone-lysine N-methyltransferase, H3 lysine-36 and H4 lysine-20 specific vs. Ensembl Zebrafish
Match: nsd2 (nuclear receptor binding SET domain protein 2 [Source:ZFIN;Acc:ZDB-GENE-030131-2581]) HSP 1 Score: 64.6994 bits (156), Expect = 8.668e-10 Identity = 111/505 (21.98%), Postives = 183/505 (36.24%), Query Frame = 1
Query: 778 CMRPYHRLC--LSAHLDMSPDMKQCPLHSCINCALDYLAEPESKRVQSHLDLVSCVKCKLAFHNIIDCLPTTFIRITRHLIICHRHLVPSDLLQSNVAQFCFYCSRSISVHNPPVSCKYCLVTYHKCLPCLSGATELLDEHTFICNACKFPYVHRGQCLALALPRETLTNDSVHSWKLGHLNLVTESTTGNKSVIVTEQTGKKWPTDIH--RTIAINLQSLDHLVS-FGVLRFQDIQY----ALRDLTKLVERVATSYNLCQ--NFYRNTFV---LRFAGLFPLVENLYYGNASTFMDPNQSRPLAKP--------------MKCDCLEACT-----TMKCPNVAANAECTDENCGAQNRCRNRRLQKRNFPRSKLLLVDEIGPYVMIDETVVKDVLVGELVGVVKSTAWAEANFQRIGPSNC----VFKLSNEAVIDCSQFCSIFRFIKTSDRPNLQVKIVTVAGFRRIGLFSSHRIVKGDILTLDF--DSLIYRVARDSCGAP 2175
C R YH C LSA +CPLH+C++C A ++ + + ++ C++C +A+H C+ I+ I+C H F + S H+ V+ +C + C G L C +C P CL +A+P + + S K V GN + WP +I + I N+Q L H + F V F Y R + + Y ++N + RF + E + P + + KP KC+C + +C N EC + C A RC+N+ KR +P +K++ G ++ + K V E VG + + + ++ + + + +ID + RF+ S +PN + + TV G R+GLF+ I G LT ++ D L CGAP
Sbjct: 825 CGRFYHEACVRLSALTVFENRGFRCPLHTCLSCHYSGRAACKATKGK----MMRCLRCPVAYHVGDLCVAAGSEMISSSAIVCTNH---------------FRAKKGYS-HHSHVNVSWCFI-------CSKGGRLL------CCESC--PAAFHPDCLNIAMPDGSWFCNDCRSGKKPKYRDVIWVKLGNY---------RWWPAEIRHPKNIPTNIQHLRHEIGEFPVFFFGSKDYFWTHQGRVFPYMEGDRGSKYQQTGIGKVFKNALLDAETRFKEIEMEREAKEAHENNKKPPPFKYIKVNKPCGRVQVYTADISEIPKCNCKPSTERPCSFESECLNRMLLYECHPQVCPAGERCQNQDFTKRLYPETKIIRTAGKGWGLISLRDIKKGEFVNEYVGELIDEEECRSRIRHAQENDITHFYMLTIDKDRIIDAGPKGNYSRFMNHSCQPNCETQKWTVNGDTRVGLFAVCDIPAGTELTFNYNLDCLGNEKTVCRCGAP 1285
BLAST of Histone-lysine N-methyltransferase, H3 lysine-36 and H4 lysine-20 specific vs. Ensembl Zebrafish
Match: ezh1 (enhancer of zeste 1 polycomb repressive complex 2 subunit [Source:ZFIN;Acc:ZDB-GENE-050114-1]) HSP 1 Score: 62.003 bits (149), Expect = 3.788e-9 Identity = 53/178 (29.78%), Postives = 81/178 (45.51%), Query Frame = 1
Query: 1666 CDCLEACTTMKCPNVAANAECTDE---NCGA-------QNRCRNRRLQKRNFPRSKLLLVDEIGPY-VMIDETVVKDVLVGELVGVVKSTAWAEANFQRIGP--SNCVFKLSNEAVIDCSQFCSIFRFIKTSDRPNLQVKIVTVAGFRRIGLFSSHRIVKGDILTLDF-----DSLIY 2145
C C C T +CP A EC + CGA Q C+N +Q R + LL ++ + I E V K+ + E G + S A+ + S+ +F L+N+ V+D ++ + RF S PN K+V V G RIG+F+ I +G+ L D+ D+L Y
Sbjct: 570 CRCKTQCNTKQCPCYLAVRECDPDLCMTCGAADHWDSKQVSCKNCSIQ-RGLKKHLLLAPSDVAGWGTFIKEPVQKNEFISEYCGELISQDEADRRGRIYDKYMSSFLFNLNNDFVVDATRKGNKIRFANHSVNPNCYAKVVMVNGDHRIGIFAKRAIQQGEELFFDYRYSQADALKY 746
BLAST of Histone-lysine N-methyltransferase, H3 lysine-36 and H4 lysine-20 specific vs. Ensembl Xenopus
Match: NSD3 (Triosephosphate isomerase [Source:UniProtKB/Swiss-Prot;Acc:B0BM40]) HSP 1 Score: 97.0561 bits (240), Expect = 1.693e-19 Identity = 130/565 (23.01%), Postives = 219/565 (38.76%), Query Frame = 1
Query: 628 CGSYCSWKYHKDCVK----DENDLVC-SCNKSVWLCSICCEVINVSQLFVCNNHTCMRPYHRLCLSAHLDMSPDMK--QCPLHSCINCALDYLAEPESKRVQSHLDLVSCVKCKLAFHNIIDCLPTTFIRITRHLIICHRHLVPSDLLQSNV-AQFCFYCSRSISVHN----PPVSCK-YCLVTYHK--------CLPCLSGA----TELLDEHTFICNACKFPYVHRGQCLALALPRETLTNDSVHSWKLGHLNLVTESTTGNKSVIVTEQTGKKWPTDI--HRTIAINLQSLDHLVS-FGVLRFQDIQYALRDLTKLVERVA--TSYNLCQNFYRNTF---VLRFAGLFPLVENLYYGNASTFMDPNQSRP---------------------LAKPMKCDCLEACTT-----MKCPNVAANAECTDENCGAQNRCRNRRLQKRNFPRSKLLLVDEIGPYVMIDETVVKDVLVGELVGVVKSTAWAEANFQRI---GPSN-CVFKLSNEAVIDCSQFCSIFRFIKTSDRPNLQVKIVTVAGFRRIGLFSSHRIVKGDILTLDFD 2133
C CS +H +C+ + +C C + C C I + + C+ C + YH C + D K +CP H C +C D + ++SCV+C +A+HN C+ + ++ LIIC H S S+V FCF C+R + V + +S K + L+T K +P S A +E C++C P CL L +P+ + + + S K H + GN + WP +I R++ +N+Q L H + F V F Y ++ V S+ Q TF + A F ++ + ++ N +P L++ +C+C T +C N EC + C A C N+ KR +P +++ + + G + + K V E VG + +R G +N + ++ + +ID + RF+ S PN + + TV G R+GLF+ I KG LT +++
Sbjct: 730 CDGECSRLFHLECLGMDTLPDGKFICMECKTGLHTCFSC--KIPSTSVKRCSAPCCGKFYHETCARQYSATIFDSKGFRCPHHCCSSCTAD-----KDPYRACKGRMLSCVRCPVAYHNGDSCIAAGSLHLSSSLIICSNHSKRSGHASSSVNVGFCFVCARGLIVQDYSLVSSMSFKSHFLLTDSKRAELMKIPMIPSSSPAYIKKSEKGGGKLLCCDSC--PAAFHPSCLNLEMPQGSWSCNDCRSGKKLHYKQIVWVKLGNY---------RWWPAEICNPRSVPLNIQGLKHDIGDFPVFFFGSHDYYWVHQGRVFPYVEGDKSFADGQTSINKTFKKALEEAARRFQELKAQRESKEALEIEQNSRKPPPYKHIKSNKPVGKVQIQLADLSEIPRCNCRPTDDTPCGLDTECLNRMLLYECHPQICPAGEHCLNQNFTKRLYPEAEIFITERRGWGLRTKRDIRKGEFVNEYVGELIDEEECRQRMKRAHENGTTNFYLLTVTKDRIIDAGPKGNYSRFMNHSCNPNCETQKWTVNGDVRVGLFALCDIPKGAELTFNYN 1276
BLAST of Histone-lysine N-methyltransferase, H3 lysine-36 and H4 lysine-20 specific vs. Ensembl Xenopus
Match: NSD3 (Triosephosphate isomerase [Source:UniProtKB/Swiss-Prot;Acc:B0BM40]) HSP 1 Score: 96.6709 bits (239), Expect = 2.257e-19 Identity = 130/564 (23.05%), Postives = 219/564 (38.83%), Query Frame = 1
Query: 628 CGSYCSWKYHKDCVK----DENDLVC-SCNKSVWLCSICCEVINVSQLFVCNNHTCMRPYHRLCLSAHLDMSPDMK--QCPLHSCINCALDYLAEPESKRVQSHLDLVSCVKCKLAFHNIIDCLPTTFIRITRHLIICHRHLVPSDLLQSNV-AQFCFYCSRSISVHN----PPVSCK-YCLVTYHK--------CLPCLSGATELLDEHT---FICNACKFPYVHRGQCLALALPRETLTNDSVHSWKLGHLNLVTESTTGNKSVIVTEQTGKKWPTDI--HRTIAINLQSLDHLVS-FGVLRFQDIQYALRDLTKLVERVA--TSYNLCQNFYRNTF---VLRFAGLFPLVENLYYGNASTFMDPNQSRP---------------------LAKPMKCDCLEACTT-----MKCPNVAANAECTDENCGAQNRCRNRRLQKRNFPRSKLLLVDEIGPYVMIDETVVKDVLVGELVGVVKSTAWAEANFQRI---GPSN-CVFKLSNEAVIDCSQFCSIFRFIKTSDRPNLQVKIVTVAGFRRIGLFSSHRIVKGDILTLDFD 2133
C CS +H +C+ + +C C + C C I + + C+ C + YH C + D K +CP H C +C D + ++SCV+C +A+HN C+ + ++ LIIC H S S+V FCF C+R + V + +S K + L+T K +P S A E C++C P CL L +P+ + + + S K H + GN + + WP +I R++ +N+Q L H + F V F Y ++ V S+ Q TF + A F ++ + ++ N +P L++ +C+C T +C N EC + C A C N+ KR +P +++ + + G + + K V E VG + +R G +N + ++ + +ID + RF+ S PN + + TV G R+GLF+ I KG LT +++
Sbjct: 694 CDGECSRLFHLECLGMDTLPDGKFICMECKTGLHTCFSC--KIPSTSVKRCSAPCCGKFYHETCARQYSATIFDSKGFRCPHHCCSSCTAD-----KDPYRACKGRMLSCVRCPVAYHNGDSCIAAGSLHLSSSLIICSNHSKRSGHASSSVNVGFCFVCARGLIVQDYSLVSSMSFKSHFLLTDSKRAELMKIPMIPSSSPAYIKKSEKGGKLLCCDSC--PAAFHPSCLNLEMPQGSWSCNDCRSGKKLHYKQIVWVKLGNYRQV---ELSVWWPAEICNPRSVPLNIQGLKHDIGDFPVFFFGSHDYYWVHQGRVFPYVEGDKSFADGQTSINKTFKKALEEAARRFQELKAQRESKEALEIEQNSRKPPPYKHIKSNKPVGKVQIQLADLSEIPRCNCRPTDDTPCGLDTECLNRMLLYECHPQICPAGEHCLNQNFTKRLYPEAEIFITERRGWGLRTKRDIRKGEFVNEYVGELIDEEECRQRMKRAHENGTTNFYLLTVTKDRIIDAGPKGNYSRFMNHSCNPNCETQKWTVNGDVRVGLFALCDIPKGAELTFNYN 1245
BLAST of Histone-lysine N-methyltransferase, H3 lysine-36 and H4 lysine-20 specific vs. Ensembl Xenopus
Match: NSD3 (Triosephosphate isomerase [Source:UniProtKB/Swiss-Prot;Acc:B0BM40]) HSP 1 Score: 96.2857 bits (238), Expect = 2.729e-19 Identity = 123/548 (22.45%), Postives = 206/548 (37.59%), Query Frame = 1
Query: 628 CGSYCSWKYHKDCVK----DENDLVC-SCNKSVWLCSICCEVINVSQLFVCNNHTCMRPYHRLCLSAHLDMSPDMK--QCPLHSCINCALDYLAEPESKRVQSHLDLVSCVKCKLAFHNIIDCLPTTFIRITRHLIICHRHLVPSDLLQSNV-AQFCFYCSRSISVHNPPVSCKYCLVTYHKCLPCLSGATELLDEHTFICNACKFPYVHRGQCLALALPRETLTNDSVHSWKLGHLNLVTESTTGNKSVIVTEQTGKKWPTDI--HRTIAINLQSLDHLVS-FGVLRFQDIQYALRDLTKLVERVA--TSYNLCQNFYRNTF---VLRFAGLFPLVENLYYGNASTFMDPNQSRP---------------------LAKPMKCDCLEACTT-----MKCPNVAANAECTDENCGAQNRCRNRRLQKRNFPRSKLLLVDEIGPYVMIDETVVKDVLVGELVGVVKSTAWAEANFQRI---GPSN-CVFKLSNEAVIDCSQFCSIFRFIKTSDRPNLQVKIVTVAGFRRIGLFSSHRIVKGDILTLDFD 2133
C CS +H +C+ + +C C + C C I + + C+ C + YH C + D K +CP H C +C D + ++SCV+C +A+HN C+ + ++ LIIC H S S+V FCF C+R G +LL C++C P CL L +P+ + + + S K H + GN + WP +I R++ +N+Q L H + F V F Y ++ V S+ Q TF + A F ++ + ++ N +P L++ +C+C T +C N EC + C A C N+ KR +P +++ + + G + + K V E VG + +R G +N + ++ + +ID + RF+ S PN + + TV G R+GLF+ I KG LT +++
Sbjct: 730 CDGECSRLFHLECLGMDTLPDGKFICMECKTGLHTCFSC--KIPSTSVKRCSAPCCGKFYHETCARQYSATIFDSKGFRCPHHCCSSCTAD-----KDPYRACKGRMLSCVRCPVAYHNGDSCIAAGSLHLSSSLIICSNHSKRSGHASSSVNVGFCFVCAR--------------------------GGGKLL-----CCDSC--PAAFHPSCLNLEMPQGSWSCNDCRSGKKLHYKQIVWVKLGNY---------RWWPAEICNPRSVPLNIQGLKHDIGDFPVFFFGSHDYYWVHQGRVFPYVEGDKSFADGQTSINKTFKKALEEAARRFQELKAQRESKEALEIEQNSRKPPPYKHIKSNKPVGKVQIQLADLSEIPRCNCRPTDDTPCGLDTECLNRMLLYECHPQICPAGEHCLNQNFTKRLYPEAEIFITERRGWGLRTKRDIRKGEFVNEYVGELIDEEECRQRMKRAHENGTTNFYLLTVTKDRIIDAGPKGNYSRFMNHSCNPNCETQKWTVNGDVRVGLFALCDIPKGAELTFNYN 1228
BLAST of Histone-lysine N-methyltransferase, H3 lysine-36 and H4 lysine-20 specific vs. Ensembl Xenopus
Match: NSD3 (Triosephosphate isomerase [Source:UniProtKB/Swiss-Prot;Acc:B0BM40]) HSP 1 Score: 95.9005 bits (237), Expect = 3.441e-19 Identity = 130/564 (23.05%), Postives = 218/564 (38.65%), Query Frame = 1
Query: 628 CGSYCSWKYHKDCVK----DENDLVC-SCNKSVWLCSICCEVINVSQLFVCNNHTCMRPYHRLCLSAHLDMSPDMK--QCPLHSCINCALDYLAEPESKRVQSHLDLVSCVKCKLAFHNIIDCLPTTFIRITRHLIICHRHLVPSDLLQSNV-AQFCFYCSRSISVHN----PPVSCK-YCLVTYHK--------CLPCLSGATELLDEHT---FICNACKFPYVHRGQCLALALPRETLTNDSVHSWKLGHLNLVTESTTGNKSVIVTEQTGKKWPTDI--HRTIAINLQSLDHLVS-FGVLRFQDIQYALRDLTKLVERVA--TSYNLCQNFYRNTF---VLRFAGLFPLVENLYYGNASTFMDPNQSRP---------------------LAKPMKCDCLEACTT-----MKCPNVAANAECTDENCGAQNRCRNRRLQKRNFPRSKLLLVDEIGPYVMIDETVVKDVLVGELVGVVKSTAWAEANFQRI---GPSN-CVFKLSNEAVIDCSQFCSIFRFIKTSDRPNLQVKIVTVAGFRRIGLFSSHRIVKGDILTLDFD 2133
C CS +H +C+ + +C C + C C I + + C+ C + YH C + D K +CP H C +C D + ++SCV+C +A+HN C+ + ++ LIIC H S S+V FCF C+R + V + +S K + L+T K +P S A E C++C P CL L +P+ + + + S K H + GN + WP +I R++ +N+Q L H + F V F Y ++ V S+ Q TF + A F ++ + ++ N +P L++ +C+C T +C N EC + C A C N+ KR +P +++ + + G + + K V E VG + +R G +N + ++ + +ID + RF+ S PN + + TV G R+GLF+ I KG LT +++
Sbjct: 723 CDGECSRLFHLECLGMDTLPDGKFICMECKTGLHTCFSC--KIPSTSVKRCSAPCCGKFYHETCARQYSATIFDSKGFRCPHHCCSSCTAD-----KDPYRACKGRMLSCVRCPVAYHNGDSCIAAGSLHLSSSLIICSNHSKRSGHASSSVNVGFCFVCARGLIVQDYSLVSSMSFKSHFLLTDSKRAELMKIPMIPSSSPAYIKKSEKGGKLLCCDSC--PAAFHPSCLNLEMPQGSWSCNDCRSGKKLHYKQIVWVKLGNY---------RWWPAEICNPRSVPLNIQGLKHDIGDFPVFFFGSHDYYWVHQGRVFPYVEGDKSFADGQTSINKTFKKALEEAARRFQELKAQRESKEALEIEQNSRKPPPYKHIKSNKPVGKVQIQLADLSEIPRCNCRPTDDTPCGLDTECLNRMLLYECHPQICPAGEHCLNQNFTKRLYPEAEIFITERRGWGLRTKRDIRKGEFVNEYVGELIDEEECRQRMKRAHENGTTNFYLLTVTKDRIIDAGPKGNYSRFMNHSCNPNCETQKWTVNGDVRVGLFALCDIPKGAELTFNYN 1268
BLAST of Histone-lysine N-methyltransferase, H3 lysine-36 and H4 lysine-20 specific vs. Ensembl Xenopus
Match: NSD3 (Triosephosphate isomerase [Source:UniProtKB/Swiss-Prot;Acc:B0BM40]) HSP 1 Score: 95.9005 bits (237), Expect = 3.903e-19 Identity = 130/564 (23.05%), Postives = 218/564 (38.65%), Query Frame = 1
Query: 628 CGSYCSWKYHKDCVK----DENDLVC-SCNKSVWLCSICCEVINVSQLFVCNNHTCMRPYHRLCLSAHLDMSPDMK--QCPLHSCINCALDYLAEPESKRVQSHLDLVSCVKCKLAFHNIIDCLPTTFIRITRHLIICHRHLVPSDLLQSNV-AQFCFYCSRSISVHN----PPVSCK-YCLVTYHK--------CLPCLSGATELLDEHT---FICNACKFPYVHRGQCLALALPRETLTNDSVHSWKLGHLNLVTESTTGNKSVIVTEQTGKKWPTDI--HRTIAINLQSLDHLVS-FGVLRFQDIQYALRDLTKLVERVA--TSYNLCQNFYRNTF---VLRFAGLFPLVENLYYGNASTFMDPNQSRP---------------------LAKPMKCDCLEACTT-----MKCPNVAANAECTDENCGAQNRCRNRRLQKRNFPRSKLLLVDEIGPYVMIDETVVKDVLVGELVGVVKSTAWAEANFQRI---GPSN-CVFKLSNEAVIDCSQFCSIFRFIKTSDRPNLQVKIVTVAGFRRIGLFSSHRIVKGDILTLDFD 2133
C CS +H +C+ + +C C + C C I + + C+ C + YH C + D K +CP H C +C D + ++SCV+C +A+HN C+ + ++ LIIC H S S+V FCF C+R + V + +S K + L+T K +P S A E C++C P CL L +P+ + + + S K H + GN + WP +I R++ +N+Q L H + F V F Y ++ V S+ Q TF + A F ++ + ++ N +P L++ +C+C T +C N EC + C A C N+ KR +P +++ + + G + + K V E VG + +R G +N + ++ + +ID + RF+ S PN + + TV G R+GLF+ I KG LT +++
Sbjct: 720 CDGECSRLFHLECLGMDTLPDGKFICMECKTGLHTCFSC--KIPSTSVKRCSAPCCGKFYHETCARQYSATIFDSKGFRCPHHCCSSCTAD-----KDPYRACKGRMLSCVRCPVAYHNGDSCIAAGSLHLSSSLIICSNHSKRSGHASSSVNVGFCFVCARGLIVQDYSLVSSMSFKSHFLLTDSKRAELMKIPMIPSSSPAYIKKSEKGGKLLCCDSC--PAAFHPSCLNLEMPQGSWSCNDCRSGKKLHYKQIVWVKLGNY---------RWWPAEICNPRSVPLNIQGLKHDIGDFPVFFFGSHDYYWVHQGRVFPYVEGDKSFADGQTSINKTFKKALEEAARRFQELKAQRESKEALEIEQNSRKPPPYKHIKSNKPVGKVQIQLADLSEIPRCNCRPTDDTPCGLDTECLNRMLLYECHPQICPAGEHCLNQNFTKRLYPEAEIFITERRGWGLRTKRDIRKGEFVNEYVGELIDEEECRQRMKRAHENGTTNFYLLTVTKDRIIDAGPKGNYSRFMNHSCNPNCETQKWTVNGDVRVGLFALCDIPKGAELTFNYN 1265
BLAST of Histone-lysine N-methyltransferase, H3 lysine-36 and H4 lysine-20 specific vs. Ensembl Mouse
Match: Nsd3 (nuclear receptor binding SET domain protein 3 [Source:MGI Symbol;Acc:MGI:2142581]) HSP 1 Score: 88.5817 bits (218), Expect = 4.764e-17 Identity = 114/564 (20.21%), Postives = 215/564 (38.12%), Query Frame = 1
Query: 628 CGSYCSWKYHKDCVK----DENDLVCS-CNKSVWLCSICCEVINVSQLFVCNNHTCMRPYHRLCLSAHLDMSPDMK--QCPLHSCINCALDYLAEPESKRVQSHLDLVSCVKCKLAFHNIIDCLPTTFIRITRHLIICHRHLVPSDLLQSNVAQFCFYCSRSISV--HNPPVSCKYCLVTYH-------------KCLPCLSGATELLDEHTFI--CNACKFPYVHRGQCLALALPRETLTNDSVHSWKLGHLNLVTESTTGNKSVIVTEQTGKKWPTDI--HRTIAINLQSLDH-LVSFGVLRFQDIQYALRDLTKLVERVATSYNLC--QNFYRNTF---VLRFAGLFPLVENLYYGNASTFMDPNQSRP---------------------LAKPMKCDCLEA-----CTTMKCPNVAANAECTDENCGAQNRCRNRRLQKRNFPRSKLLLVDEIGPYVMIDETVVKDVLVGELVGVVKSTAWAEANFQRIGPSNC----VFKLSNEAVIDCSQFCSIFRFIKTSDRPNLQVKIVTVAGFRRIGLFSSHRIVKGDILTLDFD 2133
C C +H +C+ E C C C C ++ + C+ C + YH C+ + K +CP H C +C+++ SK ++ C++C +A+H C+ + ++ H++IC H S + FCF C+R + V H+ P+ Y +++ +P S + + ++ + C +C P +CL++ +P + + K H + GN + WP +I R++ +N+Q L H L F V F Y ++ V + Q TF + A F ++ + M+ +P L++ +C+C +C N + EC + C A +RC+N+ KR +P ++++ + G + ++ K V E VG + +R ++ + ++ + +ID + RF+ S PN + + TV G R+GLF+ I G LT +++
Sbjct: 727 CEGECCRHFHVECLGLTAVPEGHFTCEECETGQHPCFSC--KVSGKDVKRCSVSVCGKFYHEACVRKFPTAIFESKGFRCPQHCCSSCSMEKDIHKASKG-----RMMRCLRCPVAYHVGDACVAAGSVSVSSHILICSNHSKRSSQSAAINVGFCFVCARGLIVQDHSDPMFSSYAYKSHYLLSESNRAELMKLPMIPSSSASKKRCEKGGRLLCCESC--PASFHPECLSIDMPEGCWNCNDCKAGKKLHYKQIVWVKLGNY---------RWWPAEICSPRSVPLNIQGLKHDLGDFPVFFFGSHDYYWVHQGRVFPYVEGDKHFAEGQTSINKTFKKALEEAAKRFQELKAQRESKEALEMERTSRKPPPYKHIKANKVIGKVQVQVADLSEIPRCNCKPGDENPCGLESQCLNRMSQYECHPQVCPAGDRCQNQCFTKRLYPDAEVIKTERRGWGLRTKRSIKKGEFVNEYVGELIDEEECRLRIKRAHENSVTNFYMLTVTKDRIIDAGPKGNYSRFMNHSCNPNCETQKWTVNGDVRVGLFALCDIPAGMELTFNYN 1272
BLAST of Histone-lysine N-methyltransferase, H3 lysine-36 and H4 lysine-20 specific vs. Ensembl Mouse
Match: Nsd3 (nuclear receptor binding SET domain protein 3 [Source:MGI Symbol;Acc:MGI:2142581]) HSP 1 Score: 88.5817 bits (218), Expect = 4.764e-17 Identity = 114/564 (20.21%), Postives = 215/564 (38.12%), Query Frame = 1
Query: 628 CGSYCSWKYHKDCVK----DENDLVCS-CNKSVWLCSICCEVINVSQLFVCNNHTCMRPYHRLCLSAHLDMSPDMK--QCPLHSCINCALDYLAEPESKRVQSHLDLVSCVKCKLAFHNIIDCLPTTFIRITRHLIICHRHLVPSDLLQSNVAQFCFYCSRSISV--HNPPVSCKYCLVTYH-------------KCLPCLSGATELLDEHTFI--CNACKFPYVHRGQCLALALPRETLTNDSVHSWKLGHLNLVTESTTGNKSVIVTEQTGKKWPTDI--HRTIAINLQSLDH-LVSFGVLRFQDIQYALRDLTKLVERVATSYNLC--QNFYRNTF---VLRFAGLFPLVENLYYGNASTFMDPNQSRP---------------------LAKPMKCDCLEA-----CTTMKCPNVAANAECTDENCGAQNRCRNRRLQKRNFPRSKLLLVDEIGPYVMIDETVVKDVLVGELVGVVKSTAWAEANFQRIGPSNC----VFKLSNEAVIDCSQFCSIFRFIKTSDRPNLQVKIVTVAGFRRIGLFSSHRIVKGDILTLDFD 2133
C C +H +C+ E C C C C ++ + C+ C + YH C+ + K +CP H C +C+++ SK ++ C++C +A+H C+ + ++ H++IC H S + FCF C+R + V H+ P+ Y +++ +P S + + ++ + C +C P +CL++ +P + + K H + GN + WP +I R++ +N+Q L H L F V F Y ++ V + Q TF + A F ++ + M+ +P L++ +C+C +C N + EC + C A +RC+N+ KR +P ++++ + G + ++ K V E VG + +R ++ + ++ + +ID + RF+ S PN + + TV G R+GLF+ I G LT +++
Sbjct: 727 CEGECCRHFHVECLGLTAVPEGHFTCEECETGQHPCFSC--KVSGKDVKRCSVSVCGKFYHEACVRKFPTAIFESKGFRCPQHCCSSCSMEKDIHKASKG-----RMMRCLRCPVAYHVGDACVAAGSVSVSSHILICSNHSKRSSQSAAINVGFCFVCARGLIVQDHSDPMFSSYAYKSHYLLSESNRAELMKLPMIPSSSASKKRCEKGGRLLCCESC--PASFHPECLSIDMPEGCWNCNDCKAGKKLHYKQIVWVKLGNY---------RWWPAEICSPRSVPLNIQGLKHDLGDFPVFFFGSHDYYWVHQGRVFPYVEGDKHFAEGQTSINKTFKKALEEAAKRFQELKAQRESKEALEMERTSRKPPPYKHIKANKVIGKVQVQVADLSEIPRCNCKPGDENPCGLESQCLNRMSQYECHPQVCPAGDRCQNQCFTKRLYPDAEVIKTERRGWGLRTKRSIKKGEFVNEYVGELIDEEECRLRIKRAHENSVTNFYMLTVTKDRIIDAGPKGNYSRFMNHSCNPNCETQKWTVNGDVRVGLFALCDIPAGMELTFNYN 1272
BLAST of Histone-lysine N-methyltransferase, H3 lysine-36 and H4 lysine-20 specific vs. Ensembl Mouse
Match: Nsd3 (nuclear receptor binding SET domain protein 3 [Source:MGI Symbol;Acc:MGI:2142581]) HSP 1 Score: 82.0333 bits (201), Expect = 4.828e-15 Identity = 108/547 (19.74%), Postives = 201/547 (36.75%), Query Frame = 1
Query: 628 CGSYCSWKYHKDCVK----DENDLVCS-CNKSVWLCSICCEVINVSQLFVCNNHTCMRPYHRLCLSAHLDMSPDMK--QCPLHSCINCALDYLAEPESKRVQSHLDLVSCVKCKLAFHNIIDCLPTTFIRITRHLIICHRHLVPSDLLQSNVAQFCFYCSRSISVHNPPVSCKYCLVTYHKCLPCLSGATELLDEHTFICNACKFPYVHRGQCLALALPRETLTNDSVHSWKLGHLNLVTESTTGNKSVIVTEQTGKKWPTDI--HRTIAINLQSLDH-LVSFGVLRFQDIQYALRDLTKLVERVATSYNLC--QNFYRNTF---VLRFAGLFPLVENLYYGNASTFMDPNQSRP---------------------LAKPMKCDCLEA-----CTTMKCPNVAANAECTDENCGAQNRCRNRRLQKRNFPRSKLLLVDEIGPYVMIDETVVKDVLVGELVGVVKSTAWAEANFQRIGPSNC----VFKLSNEAVIDCSQFCSIFRFIKTSDRPNLQVKIVTVAGFRRIGLFSSHRIVKGDILTLDFD 2133
C C +H +C+ E C C C C ++ + C+ C + YH C+ + K +CP H C +C+++ SK ++ C++C +A+H C+ + ++ H++IC H S + FCF C+R + + C+ C ++H +CL++ +P + + K H + GN + WP +I R++ +N+Q L H L F V F Y ++ V + Q TF + A F ++ + M+ +P L++ +C+C +C N + EC + C A +RC+N+ KR +P ++++ + G + ++ K V E VG + +R ++ + ++ + +ID + RF+ S PN + + TV G R+GLF+ I G LT +++
Sbjct: 727 CEGECCRHFHVECLGLTAVPEGHFTCEECETGQHPCFSC--KVSGKDVKRCSVSVCGKFYHEACVRKFPTAIFESKGFRCPQHCCSSCSMEKDIHKASKG-----RMMRCLRCPVAYHVGDACVAAGSVSVSSHILICSNHSKRSSQSAAINVGFCFVCARGGRL----LCCESCPASFHP------------------------------ECLSIDMPEGCWNCNDCKAGKKLHYKQIVWVKLGNY---------RWWPAEICSPRSVPLNIQGLKHDLGDFPVFFFGSHDYYWVHQGRVFPYVEGDKHFAEGQTSINKTFKKALEEAAKRFQELKAQRESKEALEMERTSRKPPPYKHIKANKVIGKVQVQVADLSEIPRCNCKPGDENPCGLESQCLNRMSQYECHPQVCPAGDRCQNQCFTKRLYPDAEVIKTERRGWGLRTKRSIKKGEFVNEYVGELIDEEECRLRIKRAHENSVTNFYMLTVTKDRIIDAGPKGNYSRFMNHSCNPNCETQKWTVNGDVRVGLFALCDIPAGMELTFNYN 1223
BLAST of Histone-lysine N-methyltransferase, H3 lysine-36 and H4 lysine-20 specific vs. Ensembl Mouse
Match: Nsd2 (nuclear receptor binding SET domain protein 2 [Source:MGI Symbol;Acc:MGI:1276574]) HSP 1 Score: 78.9518 bits (193), Expect = 3.748e-14 Identity = 113/551 (20.51%), Postives = 205/551 (37.21%), Query Frame = 1
Query: 628 CGSYCSWKYHKDCV----KDENDLVCS-CNKSVWLCSICCEVINVSQLFVCNNHTCMRPYHRLCLSAHLDMSPDMK--QCPLHSCINCALDYLAEPESKRVQSHLDLVSCVKCKLAFHNIIDCLPTTFIRITRHLIICHRHLVPSDLLQSNVAQFCFYCSRSISVHNPPVSCKYCLVTYHKCLPCLSGATELLDEHTFICNACKFPYVHRGQCLALALPRETLTNDSVHSWKLGHLNLVTESTTGNKSVIVTEQTGKKWPTDI--HRTIAINLQSLDHLVS------FGVL--------------------RFQDIQYALRDLTKLVERVATSYNLCQNFYRNTFVLRFAGLFP-----LVENLYYGNASTFMDPNQSRPLAKPMKCDCLEA-----CTTMKCPNVAANAECTDENCGAQNRCRNRRLQKRNFPRSKLLLVDEIGPYVMIDETVVKDVLVGELVGVVKSTAWAEANFQRIGPSNC----VFKLSNEAVIDCSQFCSIFRFIKTSDRPNLQVKIVTVAGFRRIGLFSSHRIVKGDILTLDFD 2133
C C +H C+ + E C+ C + C +C E + ++ C + C + YH C+ + + + +CPLHSC++C + + P + R S ++ CV+C +A+H CL I + IIC H + +R H+ V+ +C V C G + L C AC P CL + +P + + + K H + GN + WP ++ + + N+Q + H + FG R+Q ++ R ++ +N + R + + P + N YG + + +++ KC+C + +C N EC + C A C+N+ KR +P +K++ D G ++ + K V E VG + A + ++ + + + +ID + RF+ S +PN + TV G R+GLF+ I G LT +++
Sbjct: 683 CEGPCCGAFHLACLGLSRRPEGRFTCTECASGIHSCFVCKE--SKMEVKRCVVNQCGKFYHEACVKKYPLTVFESRGFRCPLHSCMSC---HASNPSNPR-PSKGKMMRCVRCPVAYHGGDACLAAGCSVIASNSIICTGH----------------FTARKGKRHHTHVNVSWCFV-------CSKGGSLL------CCEAC--PAAFHPDCLNIEMPDGSWFCNDCRAGKKLHFQDIIWVKLGNY---------RWWPAEVCHPKNVPPNIQKMKHEIGEFPVFFFGSKDYYWTHQARVFPYMEGDRGSRYQGVRGIGRVFKNALQEAEARFNEVK-LQREARETQESERKPPPYKHIKVNKPYGKVQIY-----TADISEIPKCNCKPTDENPCGSDSECLNRMLMFECHPQVCPAGEYCQNQCFTKRQYPETKIIKTDGKGWGLVAKRDIRKGEFVNEYVGELIDEEECMARIKYAHENDITHFYMLTIDKDRIIDAGPKGNYSRFMNHSCQPNCETLKWTVNGDTRVGLFAVCDIPAGTELTFNYN 1181
BLAST of Histone-lysine N-methyltransferase, H3 lysine-36 and H4 lysine-20 specific vs. Ensembl Mouse
Match: Nsd2 (nuclear receptor binding SET domain protein 2 [Source:MGI Symbol;Acc:MGI:1276574]) HSP 1 Score: 78.9518 bits (193), Expect = 3.748e-14 Identity = 113/551 (20.51%), Postives = 205/551 (37.21%), Query Frame = 1
Query: 628 CGSYCSWKYHKDCV----KDENDLVCS-CNKSVWLCSICCEVINVSQLFVCNNHTCMRPYHRLCLSAHLDMSPDMK--QCPLHSCINCALDYLAEPESKRVQSHLDLVSCVKCKLAFHNIIDCLPTTFIRITRHLIICHRHLVPSDLLQSNVAQFCFYCSRSISVHNPPVSCKYCLVTYHKCLPCLSGATELLDEHTFICNACKFPYVHRGQCLALALPRETLTNDSVHSWKLGHLNLVTESTTGNKSVIVTEQTGKKWPTDI--HRTIAINLQSLDHLVS------FGVL--------------------RFQDIQYALRDLTKLVERVATSYNLCQNFYRNTFVLRFAGLFP-----LVENLYYGNASTFMDPNQSRPLAKPMKCDCLEA-----CTTMKCPNVAANAECTDENCGAQNRCRNRRLQKRNFPRSKLLLVDEIGPYVMIDETVVKDVLVGELVGVVKSTAWAEANFQRIGPSNC----VFKLSNEAVIDCSQFCSIFRFIKTSDRPNLQVKIVTVAGFRRIGLFSSHRIVKGDILTLDFD 2133
C C +H C+ + E C+ C + C +C E + ++ C + C + YH C+ + + + +CPLHSC++C + + P + R S ++ CV+C +A+H CL I + IIC H + +R H+ V+ +C V C G + L C AC P CL + +P + + + K H + GN + WP ++ + + N+Q + H + FG R+Q ++ R ++ +N + R + + P + N YG + + +++ KC+C + +C N EC + C A C+N+ KR +P +K++ D G ++ + K V E VG + A + ++ + + + +ID + RF+ S +PN + TV G R+GLF+ I G LT +++
Sbjct: 683 CEGPCCGAFHLACLGLSRRPEGRFTCTECASGIHSCFVCKE--SKMEVKRCVVNQCGKFYHEACVKKYPLTVFESRGFRCPLHSCMSC---HASNPSNPR-PSKGKMMRCVRCPVAYHGGDACLAAGCSVIASNSIICTGH----------------FTARKGKRHHTHVNVSWCFV-------CSKGGSLL------CCEAC--PAAFHPDCLNIEMPDGSWFCNDCRAGKKLHFQDIIWVKLGNY---------RWWPAEVCHPKNVPPNIQKMKHEIGEFPVFFFGSKDYYWTHQARVFPYMEGDRGSRYQGVRGIGRVFKNALQEAEARFNEVK-LQREARETQESERKPPPYKHIKVNKPYGKVQIY-----TADISEIPKCNCKPTDENPCGSDSECLNRMLMFECHPQVCPAGEYCQNQCFTKRQYPETKIIKTDGKGWGLVAKRDIRKGEFVNEYVGELIDEEECMARIKYAHENDITHFYMLTIDKDRIIDAGPKGNYSRFMNHSCQPNCETLKWTVNGDTRVGLFAVCDIPAGTELTFNYN 1181
BLAST of Histone-lysine N-methyltransferase, H3 lysine-36 and H4 lysine-20 specific vs. UniProt/SwissProt
Match: sp|Q6P2L6|NSD3_MOUSE (Histone-lysine N-methyltransferase NSD3 OS=Mus musculus OX=10090 GN=Nsd3 PE=1 SV=2) HSP 1 Score: 89.7373 bits (221), Expect = 1.215e-16 Identity = 114/564 (20.21%), Postives = 216/564 (38.30%), Query Frame = 1
Query: 628 CGSYCSWKYHKDCVK----DENDLVCS-CNKSVWLCSICCEVINVSQLFVCNNHTCMRPYHRLCLSAHLDMSPDMK--QCPLHSCINCALDYLAEPESKRVQSHLDLVSCVKCKLAFHNIIDCLPTTFIRITRHLIICHRHLVPSDLLQSNVAQFCFYCSRSISV--HNPPVSCKYCLVTYH-------------KCLPCLSGATELLDEHTFI--CNACKFPYVHRGQCLALALPRETLTNDSVHSWKLGHLNLVTESTTGNKSVIVTEQTGKKWPTDI--HRTIAINLQSLDH-LVSFGVLRFQDIQYALRDLTKLVERVATSYNLC--QNFYRNTF---VLRFAGLFPLVENLYYGNASTFMDPNQSRP---------------------LAKPMKCDCLEA-----CTTMKCPNVAANAECTDENCGAQNRCRNRRLQKRNFPRSKLLLVDEIGPYVMIDETVVKDVLVGELVGVVKSTAWAEANFQRIGPSNC----VFKLSNEAVIDCSQFCSIFRFIKTSDRPNLQVKIVTVAGFRRIGLFSSHRIVKGDILTLDFD 2133
C C +H +C+ E C C C C ++ + C+ C + YH C+ + K +CP H C +C+++ SK ++ C++C +A+H C+ + ++ H++IC H S + FCF C+R + V H+ P+ Y +++ +P S + + ++ + C +C P +CL++ +P + + K H + GN ++ WP +I R++ +N+Q L H L F V F Y ++ V + Q TF + A F ++ + M+ +P L++ +C+C +C N + EC + C A +RC+N+ KR +P ++++ + G + ++ K V E VG + +R ++ + ++ + +ID + RF+ S PN + + TV G R+GLF+ I G LT +++
Sbjct: 717 CEGECCRHFHVECLGLTAVPEGHFTCEECETGQHPCFSC--KVSGKDVKRCSVSVCGKFYHEACVRKFPTAIFESKGFRCPQHCCSSCSMEKDIHKASKG-----RMMRCLRCPVAYHVGDACVAAGSVSVSSHILICSNHSKRSSQSAAINVGFCFVCARGLIVQDHSDPMFSSYAYKSHYLLSESNRAELMKLPMIPSSSASKKRCEKGGRLLCCESC--PASFHPECLSIDMPEGCWNCNDCKAGKKLHYKQIVWVKLGNYRQVLW------WPAEICSPRSVPLNIQGLKHDLGDFPVFFFGSHDYYWVHQGRVFPYVEGDKHFAEGQTSINKTFKKALEEAAKRFQELKAQRESKEALEMERTSRKPPPYKHIKANKVIGKVQVQVADLSEIPRCNCKPGDENPCGLESQCLNRMSQYECHPQVCPAGDRCQNQCFTKRLYPDAEVIKTERRGWGLRTKRSIKKGEFVNEYVGELIDEEECRLRIKRAHENSVTNFYMLTVTKDRIIDAGPKGNYSRFMNHSCNPNCETQKWTVNGDVRVGLFALCDIPAGMELTFNYN 1265
BLAST of Histone-lysine N-methyltransferase, H3 lysine-36 and H4 lysine-20 specific vs. UniProt/SwissProt
Match: sp|Q9BZ95|NSD3_HUMAN (Histone-lysine N-methyltransferase NSD3 OS=Homo sapiens OX=9606 GN=NSD3 PE=1 SV=1) HSP 1 Score: 88.1965 bits (217), Expect = 4.179e-16 Identity = 106/514 (20.62%), Postives = 202/514 (39.30%), Query Frame = 1
Query: 763 CNNHTCMRPYHRLCLSAHLDMSPDMK--QCPLHSCINCALDYLAEPESKRVQSHLDLVSCVKCKLAFHNIIDCLPTTFIRITRHLIICHRHLVPSDLLQSNVAQFCFYCSRSISV--HNPPVSCKYCLVTYH-------------KCLPCLSGATELLDEHTFI--CNACKFPYVHRGQCLALALPRETLTNDSVHSWKLGHLNLVTESTTGNKSVIVTEQTGKKWPTDI--HRTIAINLQSLDH-LVSFGVLRFQDIQYALRDLTKLVERVA--TSYNLCQNFYRNTF---VLRFAGLFPLVENLYYGNASTFMDPNQSRP---------------------LAKPMKCDCLEA-----CTTMKCPNVAANAECTDENCGAQNRCRNRRLQKRNFPRSKLLLVDEIGPYVMIDETVVKDVLVGELVGVVKSTAWAEANFQRIGPSNC----VFKLSNEAVIDCSQFCSIFRFIKTSDRPNLQVKIVTVAGFRRIGLFSSHRIVKGDILTLDFD 2133
C+ C + YH C+ + K +CP H C C+++ SK ++ C++C +A+H+ C+ + ++ +++IC H S + FCF C+R + V H+ P+ Y +++ +P S + + ++ + C +C P +CL++ +P + + K H + GN + WP +I R++ +N+Q L H L F V F Y ++ V S+ Q TF + A F ++ + ++ N +P L++ +C+C A +C N EC + C A +RC+N+ KR +P ++++ + G + ++ K V E VG + +R ++ + ++ + +ID + RF+ S PN + + TV G R+GLF+ I G LT +++
Sbjct: 765 CSVGACGKFYHEACVRKFPTAIFESKGFRCPQHCCSACSMEKDIHKASKG-----RMMRCLRCPVAYHSGDACIAAGSMLVSSYILICSNHSKRSSNSSAVNVGFCFVCARGLIVQDHSDPMFSSYAYKSHYLLNESNRAELMKLPMIPSSSASKKKCEKGGRLLCCESC--PASFHPECLSIEMPEGCWNCNDCKAGKKLHYKQIVWVKLGNY---------RWWPAEICNPRSVPLNIQGLKHDLGDFPVFFFGSHDYYWVHQGRVFPYVEGDKSFAEGQTSINKTFKKALEEAAKRFQELKAQRESKEALEIEKNSRKPPPYKHIKANKVIGKVQIQVADLSEIPRCNCKPADENPCGLESECLNRMLQYECHPQVCPAGDRCQNQCFTKRLYPDAEIIKTERRGWGLRTKRSIKKGEFVNEYVGELIDEEECRLRIKRAHENSVTNFYMLTVTKDRIIDAGPKGNYSRFMNHSCNPNCETQKWTVNGDVRVGLFALCDIPAGMELTFNYN 1262
BLAST of Histone-lysine N-methyltransferase, H3 lysine-36 and H4 lysine-20 specific vs. UniProt/SwissProt
Match: sp|Q8BVE8|NSD2_MOUSE (Histone-lysine N-methyltransferase NSD2 OS=Mus musculus OX=10090 GN=Nsd2 PE=1 SV=2) HSP 1 Score: 78.9518 bits (193), Expect = 2.689e-13 Identity = 113/551 (20.51%), Postives = 205/551 (37.21%), Query Frame = 1
Query: 628 CGSYCSWKYHKDCV----KDENDLVCS-CNKSVWLCSICCEVINVSQLFVCNNHTCMRPYHRLCLSAHLDMSPDMK--QCPLHSCINCALDYLAEPESKRVQSHLDLVSCVKCKLAFHNIIDCLPTTFIRITRHLIICHRHLVPSDLLQSNVAQFCFYCSRSISVHNPPVSCKYCLVTYHKCLPCLSGATELLDEHTFICNACKFPYVHRGQCLALALPRETLTNDSVHSWKLGHLNLVTESTTGNKSVIVTEQTGKKWPTDI--HRTIAINLQSLDHLVS------FGVL--------------------RFQDIQYALRDLTKLVERVATSYNLCQNFYRNTFVLRFAGLFP-----LVENLYYGNASTFMDPNQSRPLAKPMKCDCLEA-----CTTMKCPNVAANAECTDENCGAQNRCRNRRLQKRNFPRSKLLLVDEIGPYVMIDETVVKDVLVGELVGVVKSTAWAEANFQRIGPSNC----VFKLSNEAVIDCSQFCSIFRFIKTSDRPNLQVKIVTVAGFRRIGLFSSHRIVKGDILTLDFD 2133
C C +H C+ + E C+ C + C +C E + ++ C + C + YH C+ + + + +CPLHSC++C + + P + R S ++ CV+C +A+H CL I + IIC H + +R H+ V+ +C V C G + L C AC P CL + +P + + + K H + GN + WP ++ + + N+Q + H + FG R+Q ++ R ++ +N + R + + P + N YG + + +++ KC+C + +C N EC + C A C+N+ KR +P +K++ D G ++ + K V E VG + A + ++ + + + +ID + RF+ S +PN + TV G R+GLF+ I G LT +++
Sbjct: 682 CEGPCCGAFHLACLGLSRRPEGRFTCTECASGIHSCFVCKE--SKMEVKRCVVNQCGKFYHEACVKKYPLTVFESRGFRCPLHSCMSC---HASNPSNPR-PSKGKMMRCVRCPVAYHGGDACLAAGCSVIASNSIICTGH----------------FTARKGKRHHTHVNVSWCFV-------CSKGGSLL------CCEAC--PAAFHPDCLNIEMPDGSWFCNDCRAGKKLHFQDIIWVKLGNY---------RWWPAEVCHPKNVPPNIQKMKHEIGEFPVFFFGSKDYYWTHQARVFPYMEGDRGSRYQGVRGIGRVFKNALQEAEARFNEVK-LQREARETQESERKPPPYKHIKVNKPYGKVQIY-----TADISEIPKCNCKPTDENPCGSDSECLNRMLMFECHPQVCPAGEYCQNQCFTKRQYPETKIIKTDGKGWGLVAKRDIRKGEFVNEYVGELIDEEECMARIKYAHENDITHFYMLTIDKDRIIDAGPKGNYSRFMNHSCQPNCETLKWTVNGDTRVGLFAVCDIPAGTELTFNYN 1180
BLAST of Histone-lysine N-methyltransferase, H3 lysine-36 and H4 lysine-20 specific vs. UniProt/SwissProt
Match: sp|O96028|NSD2_HUMAN (Histone-lysine N-methyltransferase NSD2 OS=Homo sapiens OX=9606 GN=NSD2 PE=1 SV=1) HSP 1 Score: 74.3294 bits (181), Expect = 6.533e-12 Identity = 114/545 (20.92%), Postives = 198/545 (36.33%), Query Frame = 1
Query: 628 CGSYCSWKYHKDCV----KDENDLVCS-CNKSVWLCSICCEVINVSQLFVCNNHTCMRPYHRLCLSAHLDMSPDMK--QCPLHSCINCALDYLAEPESKRVQSHLDLVSCVKCKLAFHNIIDCLPTTFIRITRHLIICHRHLVPSDLLQSNVAQFCFYCSRSISVHNPPVSCKYCLVTYHKCLPCLSGATELLDEHTFICNACKFPYVHRGQCLALALPRETLTNDSVHSWKLGHLNLVTESTTGNKSVIVTEQTGKKWPTDI--HRTIAINLQSLDHLVS-FGVLRFQDIQY----ALRDLTKLVERVATSYNLCQNFYRNTFVLRFAGLFPLVENLYYGNASTFMDPNQSRPLAKPMKCDCLEACTTMKCPNVAANAEC----TDEN-CGAQNRCRNRRLQ--------------------KRNFPRSKLLLVDEIGPYVMIDETVVKDVLVGELVGVVKSTAWAEANFQRIGPSNC----VFKLSNEAVIDCSQFCSIFRFIKTSDRPNLQVKIVTVAGFRRIGLFSSHRIVKGDILTLDFD 2133
C C +H C+ + E CS C + C +C E + + + C C + YH C+ + + + +CPLHSC++C + + P + R S ++ CV+C +A+H+ CL I + IIC H + +R H+ V+ +C V C G + L C +C P CL + +P + + + K H + GN + WP ++ + + N+Q + H + F V F Y R + + Y + R E A + + P K +K + + +++ +C TDEN CG + C NR L KR +P +K++ D G ++ + K V E VG + A + ++ + + + +ID + RF+ S +PN + TV G R+GLF+ I G LT +++
Sbjct: 682 CEGPCCGAFHLACLGLSRRPEGRFTCSECASGIHSCFVCKE--SKTDVKRCVVTQCGKFYHEACVKKYPLTVFESRGFRCPLHSCVSC---HASNPSNPR-PSKGKMMRCVRCPVAYHSGDACLAAGCSVIASNSIICTAH----------------FTARKGKRHHAHVNVSWCFV-------CSKGGSLL------CCESC--PAAFHPDCLNIEMPDGSWFCNDCRAGKKLHFQDIIWVKLGNY---------RWWPAEVCHPKNVPPNIQKMKHEIGEFPVFFFGSKDYYWTHQARVFPYMEGDRGSRYQGVRGIGRVFKNALQEAEARFREIKLQREARETQESERKPPPYKHIKVNKPYGKVQIYTADISEIPKCNCKPTDENPCGFDSECLNRMLMFECHPQVCPAGEFCQNQCFTKRQYPETKIIKTDGKGWGLVAKRDIRKGEFVNEYVGELIDEEECMARIKHAHENDITHFYMLTIDKDRIIDAGPKGNYSRFMNHSCQPNCETLKWTVNGDTRVGLFAVCDIPAGTELTFNYN 1180
BLAST of Histone-lysine N-methyltransferase, H3 lysine-36 and H4 lysine-20 specific vs. UniProt/SwissProt
Match: sp|P93831|CLF_ARATH (Histone-lysine N-methyltransferase CLF OS=Arabidopsis thaliana OX=3702 GN=CLF PE=1 SV=2) HSP 1 Score: 66.2402 bits (160), Expect = 1.608e-9 Identity = 56/209 (26.79%), Postives = 88/209 (42.11%), Query Frame = 1
Query: 1666 CDCLEA-CTTMKCPNVAANAECTDENC------------------GAQNRCRNRRLQKRNFPRSKLLLVDEIGPYVMIDETVVKDVLVGELVGVVKSTAWAEANFQRIGPSNC--VFKLSNEAVIDCSQFCSIFRFIKTSDRPNLQVKIVTVAGFRRIGLFSSHRIVKGDILTLDFDSLIYRVARDSCGAPTDTPARLETWKEALVAPA 2229
C C ++ C + +CP AA+ EC + C G CRN +L + R L + D G + +V K +GE G + S A+ + NC +F L+++ V+D + +F S PN K++ VAG R+G+F+ RI+ G+ L D YR D A P + K+ V P+
Sbjct: 691 CHCAKSQCRSRQCPCFAADRECDPDVCRNCWVIGGDGSLGVPSQRGDNYECRNMKLLLKQQQRVLLGISDVSGWGAFLKNSVSKHEYLGEYTGELISHKEADKRGKIYDRENCSFLFNLNDQFVLDAYRKGDKLKFANHSPEPNCYAKVIMVAGDHRVGIFAKERILAGEELFYD-----YRYEPDRAPAWAKKPEAPGSKKDENVTPS 894
BLAST of Histone-lysine N-methyltransferase, H3 lysine-36 and H4 lysine-20 specific vs. TrEMBL
Match: A0A2B4STF6 (Histone-lysine N-methyltransferase NSD2 OS=Stylophora pistillata OX=50429 GN=Whsc1 PE=4 SV=1) HSP 1 Score: 100.908 bits (250), Expect = 1.475e-17 Identity = 134/560 (23.93%), Postives = 218/560 (38.93%), Query Frame = 1
Query: 622 TKCGSYCSWKYHKDCVK----DENDLVC-SCNKSVWLCSICCEVINVSQLFVCNNHTCMRPYHRLCLSA--HLDMSPDMKQCPLHSCINCALDYLAEPESKRVQSHLDLVSCVKCKLAFHNIIDCLPTTFIRITRHLIICHRHLVPSDLLQSNVAQ-------FCFYCSRSISVHNPPVSCKYCLVTYHKCLPCLSGATELLDEHTFICNAC-KFPYVHRGQCLALAL------------PRETLTNDSVHSWKLGHLNLVTESTTG----NKSVIVTEQTGKKWPTDI----HRTIAINLQSLDHLVSFGVLRFQDIQYALRDLTKLVERVATSYNLCQNFYRNTFVLRFAGLFPLVENLYYGNASTFMDPNQSRPLAKPMKCDCLEACTT----MKCPNVAANAECTDENCGAQNRCRNRRLQKRNFPRSKLLLVDEIGPYVMIDETVVKDVLVGELVGVVKSTAWAEANFQRIGPSNCVFKLS--NEAVIDCSQFCSIFRFIKTSDRPNLQVKIVTVAGFRRIGLFSSHRIVKGDILTLDF--DSLIYRVARDSCGA 2172
T C C +H DC+ + VC C C +C + NV Q C+ C + YH C+ D CPLH C C +K S L+ CV+C A+H + CL I+I+ HL+ C +H L + N A +CF C S+ + C+ C +H C+S E + E F C C + + G+ + + L PR+ TN + G ++ + ++ + + Q G K TD H ++ + R A +DL K+ ++ A Y++ V + +V +DP++ PM CDC ++ + C N EC C + +C+N++ QKR + + L G + E V K V E VG + A + ++ + L+ + +ID ++ RF+ S PN + + TV G R+GLF+S I +G+ LT D+ D L + +CGA
Sbjct: 510 TFCEGICGNAFHLDCIGLSVIPKGKFVCDECVTGNHCCFVCRQTGNVKQ---CSQQLCTKYYHEDCVKTFKSTKFDGDRFHCPLHFCSTCV-------RNKSSVSRGRLIRCVRCPTAYH-LSGCLVAGCIQISSHLMACSKHF----LREKNKAHHTHVNVNWCFVC----SIGGTLICCESCPAAFHP--ECIS--YEGIPEGHFFCKDCTEGKELLYGEIVWVKLGMYRWWPAQICNPRDVPTNIQNMRHQPGEFPVMFLGSRDYYWIHRGRVFSYQEGDKGSTDSGNSKHLAKIFKKALVEAKDKYAEWRTAQENKAEQDLQKMSKKPAP--------YKHIKVNKCTTAVRIV-----------IDPSEL-----PM-CDCSDSENSCGPESNCLNRMLQFECNPTRCPGKEKCQNQQFQKREYVDCEPLRTLHCGWGLRCKEDVKKGQFVIEYVGELIDEATCQERVRKGEDITNYYMLTIDKDCIIDAGPMGNLSRFMNHSCDPNCETQKWTVNGEVRVGLFASRDIKEGEELTFDYQLDCLGNEKKKCNCGA 1021
BLAST of Histone-lysine N-methyltransferase, H3 lysine-36 and H4 lysine-20 specific vs. TrEMBL
Match: A0A5K3EIX5 (Uncharacterized protein OS=Mesocestoides corti OX=53468 PE=4 SV=1) HSP 1 Score: 98.9821 bits (245), Expect = 4.637e-17 Identity = 135/598 (22.58%), Postives = 222/598 (37.12%), Query Frame = 1
Query: 625 KCGSYCSWKYHKDCV------KDEND----LVC-SCNKSVWLCSICCEVINVS----QLFVCNNHTCMRPYHRLCLSAH--LDMSPDMKQCPLHSCINCALDYLAEPESKRVQSHLDLVSCVKCKLAFHNIIDCLPTTFIRITRHLIICHRH----LVPSDLLQSNVAQFCFYCSRSISVHNPPVSCKYCLVTYHK-CLPCLSGATELLDEHTFICNAC--------------KFPYVHRGQC------------LALALPRET----LTNDSVHSWKLGHLNLVTESTTGNKSVIVTEQTGKKWPTDIHRTIAINLQSLDHLVSFGVLRFQDIQYALRDLTKLVER-------VATSYNLCQNFYRNTFVLRFA---GLFPLVENLYYGNASTFMDPNQSRPLAKPMKCDCLEACT------TMKCPNVAANAECTDENCG--AQNR---CRNRRLQKRNFPRSKLLLVDEIGPYVMIDETVVKDVLV----GELVGVVKSTAWAEANF-------------------QRIGPSNCVFKLSNEAVIDCSQFCSIFRFIKTSDRPNLQVKIVTVAGFRRIGLFSSHRIVKGDILTLDF 2130
KC C H C+ K EN C C +LC++C + + QL C C R +HR CL+ H + ++ + +CP H C C L+ +P++ V + ++ CV+C +H C P + ++ I+C H L ++ +CF C ++ + V CK C YH+ CLP + +E TF C C K P+ C LA P T + W E + ++ + KK D+ ++ + H + + I T+L + T+ L +++T ++ A F V + Y N++ Q P KCDC ++ T +C N + ECTD+ C A N C NR + P + G + + E V + V GE++GV ++ EA+ P+ + + + E VID + ++ RF+ S PNL K+ V G R+GLF+ + + D LTLD+
Sbjct: 318 KCNGPCGRIVHPRCMRYKEPPKPENQRPEIFKCPQCLTQKYLCAVCGDSSKKTNTDDQLLPCQMKGCGRHFHRGCLAQHPGVVLADTLSRCPAHVCATCCLE---DPDNVVVDPNRPMLQCVRCPRVYHTGDLCTPAGSVEVSLSHIVCPAHFSSQLSEDQHYKTQWPAWCFACLKAGADR---VFCKTCPFNYHRTCLP-EDEQVGVSEESTFTCKNCRQHIEPRYAQVVWAKIPFFRWWPCEIIHARNAPLNIFNLAHPEGTFLIHFIGSGEYQWVCRAQTFPYECGLNTSAAVLAKSNSKK---DVAFNLSAKMAPKVHEFYVNYVWKRGIPLRSMSATRLSDEELVPLSTPETAIALGLTPHQDTDAVQLAEALSSFQQVVSNQYANSALEKLAKQELP---ETKCDCAKSETETHCSKETECRNASEGIECTDQVCSVLAHNPSVDCGNRPFSVQ--PSLAVFRTTNRGFGLKVLENVKEGSFVVEFMGEVIGVEEANRRLEASIAARAAHRGHQGSTSQSRFTSETMPTTYLIRFTPELVIDAEKLGNLARFVNHSCEPNLVAKLWNVRGTLRMGLFALSPLSEQDELTLDY 900
BLAST of Histone-lysine N-methyltransferase, H3 lysine-36 and H4 lysine-20 specific vs. TrEMBL
Match: A0A5K3EIB1 (Uncharacterized protein OS=Mesocestoides corti OX=53468 PE=4 SV=1) HSP 1 Score: 98.9821 bits (245), Expect = 5.605e-17 Identity = 126/563 (22.38%), Postives = 212/563 (37.66%), Query Frame = 1
Query: 697 CNKSVWLCSICCEVINVS----QLFVCNNHTCMRPYHRLCLSAH--LDMSPDMKQCPLHSCINCALDYLAEPESKRVQSHLDLVSCVKCKLAFHNIIDCLPTTFIRITRHLIICHRH----LVPSDLLQSNVAQFCFYCSRSISVHNPPVSCKYCLVTYHK-CLPCLSGATELLDEHTFICNAC--------------KFPYVHRGQC------------LALALPRET----LTNDSVHSWKLGHLNLVTESTTGNKSVIVTEQTGKKWPTDIHRTIAINLQSLDHLVSFGVLRFQDIQYALRDLTKLVER-------VATSYNLCQNFYRNTFVLRFA---GLFPLVENLYYGNASTFMDPNQSRPLAKPMKCDCLEACT------TMKCPNVAANAECTDENCG--AQN---RCRNRRLQKRNFPRSKLLLVDEIGPYVMIDETVVKDVLV----GELVGVVKSTAWAEANF-------------------QRIGPSNCVFKLSNEAVIDCSQFCSIFRFIKTSDRPNLQVKIVTVAGFRRIGLFSSHRIVKGDILTLDF 2130
C +LC++C + + QL C C R +HR CL+ H + ++ + +CP H C C L+ +P++ V + ++ CV+C +H C P + ++ I+C H L ++ +CF C ++ + V CK C YH+ CLP + +E TF C C K P+ C LA P T + W E + ++ + KK D+ ++ + H + + I T+L + T+ L +++T ++ A F V + Y N++ Q P KCDC ++ T +C N + ECTD+ C A N C NR + P + G + + E V + V GE++GV ++ EA+ P+ + + + E VID + ++ RF+ S PNL K+ V G R+GLF+ + + D LTLD+
Sbjct: 190 CLTQKYLCAVCGDSSKKTNTDDQLLPCQMKGCGRHFHRGCLAQHPGVVLADTLSRCPAHVCATCCLE---DPDNVVVDPNRPMLQCVRCPRVYHTGDLCTPAGSVEVSLSHIVCPAHFSSQLSEDQHYKTQWPAWCFACLKAGADR---VFCKTCPFNYHRTCLP-EDEQVGVSEESTFTCKNCRQHIEPRYAQVVWAKIPFFRWWPCEIIHARNAPLNIFNLAHPEGTFLIHFIGSGEYQWVCRAQTFPYECGLNTSAAVLAKSNSKK---DVAFNLSAKMAPKVHEFYVNYVWKRGIPLRSMSATRLSDEELVPLSTPETAIALGLTPHQDTDAVQLAEALSSFQQVVSNQYANSALEKLAKQELP---ETKCDCAKSETETHCSKETECRNASEGIECTDQVCSVLAHNPSVDCGNRPFSVQ--PSLAVFRTTNRGFGLKVLENVKEGSFVVEFMGEVIGVEEANRRLEASIAARAAHRGHQGSTSQSRFTSETMPTTYLIRFTPELVIDAEKLGNLARFVNHSCEPNLVAKLWNVRGTLRMGLFALSPLSEQDELTLDY 737
BLAST of Histone-lysine N-methyltransferase, H3 lysine-36 and H4 lysine-20 specific vs. TrEMBL
Match: A0A3M6U1V1 (Uncharacterized protein OS=Pocillopora damicornis OX=46731 GN=pdam_00002115 PE=4 SV=1) HSP 1 Score: 98.5969 bits (244), Expect = 6.524e-17 Identity = 135/561 (24.06%), Postives = 217/561 (38.68%), Query Frame = 1
Query: 622 TKCGSYCSWKYHKDCVK----DENDLVC-SCNKSVWLCSICCEVINVSQLFVCNNHTCMRPYHRLCLSAHLDMSPDMKQ--CPLHSCINCALDYLAEPESKRVQSHLDLVSCVKCKLAFHNIIDCLPTTFIRITRHLIICHRHLVPSDLLQSNVAQ-------FCFYCSRSISVHNPPVSCKYCLVTYHKCLPCLSGATELLDEHTFICNAC-KFPYVHRGQCLALAL------------PRETLTNDSVHSWKLGHLNLVTESTTG----NKSVIVTEQTGKKWPTDI----HRTIAINLQSLDHLVSFGVLRFQDIQYALRDLTKLVERVATSYNLCQNFYRNTFVLRFAGLFPLVENLYYGNASTFMDPNQSRPLAKPMKCDCLEA-----CTTMKCPNVAANAECTDENCGAQNRCRNRRLQKRNFPRSKLLLVDEIGPYVMIDETVVKDVLVGELVGVVKSTAWAEANFQRIGPSNCVFKLS--NEAVIDCSQFCSIFRFIKTSDRPNLQVKIVTVAGFRRIGLFSSHRIVKGDILTLDF--DSLIYRVARDSCGA 2172
T C C +H DC+ + VC C C +C + NV Q C+ C + YH C+ D + CPLH C C +K S L+ CV+C A+H + CL I+I+ HL+ C +H L + N A +CF CS ++ + C+ C +H C+S E + E F C C + + G+ + + L PR+ TN + G ++ + ++ + + Q G K TD H ++ + R A +DL K+ ++ A Y++ V + +V +DP++ PM CDC C N EC C A+ +C+N+R QKR + + L G + E V K V E VG + A + ++ + L+ + +ID ++ RF+ S PN + + TV G R+GLF+S I +G+ L D+ D L + +CGA
Sbjct: 513 TFCEGICGNAFHLDCIGLSVIPKGKFVCDECVTGNHCCFVCRQTGNVKQ---CSQQLCTKYYHEDCVKTFKSTKFDGDRFYCPLHFCSTCV-------RNKSSVSRGRLIRCVRCPTAYH-LSGCLVAGCIQISSHLMACSKHF----LREKNKAHHTHVNVNWCFVCSIGGTL----ICCESCPAAFHP--ECIS--YEGIPEGHFFCKDCTEGKELLYGEIVWVKLGMYRWWPAQICNPRDVPTNIQNMRHQPGEFPVMFLGSRDYYWIHRGRVFSYQEGDKGSTDSGNSKHLAKIFKKALVEAKEKYAEWRTAQENKAEQDLQKMSKKPAP--------YKHIKVNKCTTAVRIV-----------IDPSEL-----PM-CDCSPDNDNPCGPESNCLNRMLQFECNPARCPAKEKCQNQRFQKREYADCEPLRTLHCGWGLRCKEDVKKGQFVIEYVGELIDEATCQERVRKGEDITNYYMLTIDKDCIIDAGPMGNLSRFMNHSCDPNCETQKWTVNGEVRVGLFASRDIKEGEELNFDYQLDCLGNEKKKCNCGA 1025
BLAST of Histone-lysine N-methyltransferase, H3 lysine-36 and H4 lysine-20 specific vs. TrEMBL
Match: A7RZJ4 (Predicted protein OS=Nematostella vectensis OX=45351 GN=v1g183768 PE=4 SV=1) HSP 1 Score: 97.0561 bits (240), Expect = 1.319e-16 Identity = 121/536 (22.57%), Postives = 208/536 (38.81%), Query Frame = 1
Query: 628 CGSYCSWKYHKDCVK----DENDLVC-SCNKSVWLCSICCEVINVSQLFVCNNHTCMRPYHRLCLSAHL--DMSPDMKQCPLHSCINCALDYLAEPESKRVQSHLDLVSCVKCKLAFHNIIDCLPTTFIRITRHLIICHRHLVP--SDLLQSNV-AQFCFYCSRSISVHNPPVSCKYCLVTYHKCLPCLSGATELLDEHTFICNACKFPYVHRGQCLALALPRETLTNDSVHSWKLGHLNLVTESTTGNKSVIVTEQTGKKWPTD-------------IHRTIAINLQSLDHLVSFGVLRFQDIQYALRDLTKLVERVATSYNLCQNFYRNTF---VLRFAGLFPLVENLYYGNAST----FMDPNQSRPLAKPMKCDCL--EACTT-MKCPNVAANAECTDENCGAQNRCRNRRLQKRNFPRSKLLLVDEIGPYVMIDETVVKDVLVGELVGVVKSTAWAEANFQRIGPSNCVFKLS--NEAVIDCSQFCSIFRFIKTSDRPNLQVKIVTVAGFRRIGLFSSHRIVKGDILTLDF 2130
CG C+ YH DC+ + C C V C +C + +V C+ C + YH+ CL ++ + D CPLH C C +K + L C++C A+H CL + IT HL++C +H +P S ++V +CF CS ++ + C+ C +H C+S E + E F C C + ++L + KLG + V Q+ + P + IH+ + Q D G + +Y + K + Y+ + + + RF P +++ +T +DP++ P+ C+C +AC C N+ EC C A ++C+N+R QKR + + G + + + K V E VG + A ++ + L+ + +ID ++ RF+ S PN + + TV G R+GLF+S + + LT D+
Sbjct: 3 CGD-CNSAYHPDCIGLSTAPKGKFKCDECTSGVHSCFVCRQTGDVK---ACSQPLCSKFYHKECLQSYKCSKIDGDRIYCPLHFCSTCI-------SNKTPVNRGRLTKCIRCPTAYH--AGCLVAGCMPITSHLMVCAKHFLPNKSKAHHTHVNVNWCFVCSIGGTL----ICCESCPAAFHP--ECIS--YEGIPEGRFYCKDC--------------VEGKSLLYGDIVWVKLGMYRWWPAMICNPRDVPTNIQSMRHQPGEFPVMFLGSHDFYWIHKGRVFSYQDGDKGTESG-----NNKYLAKVFKKALVEAKEKYDEWKKAREDKAEQDLQRFCKKPPQYKHIKTNKCTTAQRIILDPSE-MPV-----CECTPDQACGQDANCLNLMLQFECVASRCPAGDKCQNQRFQKRQYVDCEPFRAHSRGWGLRSKQAIKKGTFVIEYVGELIDDATCRERVKKGDDDTNYYMLTIDKDCIIDAGPMGNLSRFMNHSCYPNCETQKWTVNGEVRVGLFTSRDVESQEELTFDY 492
BLAST of Histone-lysine N-methyltransferase, H3 lysine-36 and H4 lysine-20 specific vs. Ensembl Cavefish
Match: nsd1b (nuclear receptor binding SET domain protein 1b [Source:ZFIN;Acc:ZDB-GENE-080519-2]) HSP 1 Score: 67.781 bits (164), Expect = 5.906e-11 Identity = 92/462 (19.91%), Postives = 163/462 (35.28%), Query Frame = 1
Query: 925 LVSCVKCKLAFHNIIDCLPTTFIRITRHLIICHRHLVPSDLLQSNV---AQFCFYCSRSISVHNPPVSCKYCLVTYHKCLPCLSGATELLDEHTFICNACKFPYVHRGQCLALALPRETLTNDSVHSWKLGHLNLVTESTTGNKSVIVTEQTGKKWPTDIH--RTIAINLQSLDHLVS-FGVLRFQDIQYALRDLTKLVERVATSYNLCQNFYRNTFVLRFAGLFPLVENLYYGNASTFMDPNQ-----------------SRPLAKPM----------KCDCL---EACTTM--KCPNVAANAECTDENCGAQNRCRNRRLQKRNFPRSKLLLVDEIGPYVMIDETVVKDVLVGELVGVVKSTAWAEANFQRIGPSNC----VFKLSNEAVIDCSQFCSIFRFIKTSDRPNLQVKIVTVAGFRRIGLFSSHRIVKGDILTLDFDSLIYRVARD--SCGAPT 2178
L CV+C +A+H C+P + + +LI+C H +P +++ +CF CS S+ + C+ C +H+ +CL + +P + + + K H V G + WP ++ + I N+ + H V F VL F Y ++ + N + + + L + A + Q +RP+ K +C+C E+ M +C N EC + C A +C+N+R KR + ++ G + + K V E VG V A ++ ++ + L + +ID + RF+ S +PN + + TV G R+GLF+ I G LT +++ + CGAP
Sbjct: 15 LTRCVRCPIAYHATDYCIPAGSVILANNLILCPNHFIPRKGCRNHEHVNVSWCFVCSEGGSL----LCCESCPAAFHR------------------------------ECLNIDMPEGSWFCNDCRAGKKPHYKEVVWVKVGRY---------RWWPAEVSNPKNIPENILRMRHDVGEFPVLFFGSNDYLWTYQARVFPYMEGDANSKEKMGKGVDSVYKKALEEAAKRFQELQAEKELRQLQEDRRNDKKPPPYKHIKANRPIGKVQIITADLSEIPRCNCRATDESPCGMDSECINRMLLYECNPQVCPAGEKCQNQRFLKREYSEVEIFRTLSRGWGLRGCHDIKKGDFVNEYVGEVIDEEECRARIRQAQENDIGNFYMLTLDKDRIIDAGPKGNEARFMNHSCQPNCETQKWTVNGDTRVGLFALVDISTGTELTFNYNLECLGNGKTVCKCGAPN 433
BLAST of Histone-lysine N-methyltransferase, H3 lysine-36 and H4 lysine-20 specific vs. Ensembl Cavefish
Match: nsd2 (nuclear receptor binding SET domain protein 2 [Source:ZFIN;Acc:ZDB-GENE-030131-2581]) HSP 1 Score: 65.855 bits (159), Expect = 2.870e-10 Identity = 120/565 (21.24%), Postives = 200/565 (35.40%), Query Frame = 1
Query: 628 CGSYCSWKYHKDCVKDEND----LVCSCNKSVWLCSICCEVINVSQLFVCNNHTCMRPYHRLCL--SAHLDMSPDMKQCPLHSCINCALDYLAEPESKRVQSHLDLVSCVKCKLAFHNIIDCLPTTFIRITRHLIICHRHLVP----SDLLQSNVAQFCFYCSRSISVHNPPVSCKYCLVTYHKCLPCLSGATELLDEHTFICNACKFPYVHRGQCLALALPRETLTNDSVHSWKLGHLNLVTESTTGNKSVIVTEQTGKKWPTDIH--RTIAINLQSLDHLVS-FGVLRFQDIQYALRDLTKLVERVATSYNLCQNFYRNTFVLRFAGLFPLVENLYYG-----NASTFMDPNQSRPLAKPMK----CDCLEACTTMKCPNVAANAECTDEN-CGAQNRCRNRRL--------------------QKRNFPRSKLLLVDEIGPYVMIDETVVKDVLVGELVGVVKSTAWAEANFQRIGPSNC----VFKLSNEAVIDCSQFCSIFRFIKTSDRPNLQVKIVTVAGFRRIGLFSSHRIVKGDILTLDF--DSLIYRVARDSCGAP 2175
C +C YH C+ ++ L +C V C C + + ++ C+ C + YH CL SA +CPLH+C++C ++ + + ++ C++C +A+H C+ +T I+C H P S NV+ +CF CS+ + + C+ C +H CL +A+P + + S K + GN + WP +I R I N+Q L H + F V F Y ++ + RN F E + A + N+ P K +K C ++ T N + TDE C ++ C NR L KR +P +K + G ++ + K V E VG + A + ++ + ++ + +ID + RF+ S +PN + + TV G R+GLF+ I G LT ++ D L CGAP
Sbjct: 699 CEGHCFATYHLQCLGLDHPTDKVLCTACRTGVHACFTCKQ--SEGEVKRCSVLHCGKYYHEACLRLSALTVFDNRGFRCPLHTCLSCHYSNRGTAKATKGK----MIRCLRCPVAYHAGDLCVAAGSEMLTSTAIVCTNHFNPKKGYSHHSHVNVS-WCFICSKGGRL----LCCESCPAAFHP------------------------------DCLNIAMPDGSWFCNDCRSGKKPKYRDIIWVKLGNY---------RWWPAEIRHPRNIPTNIQHLRHEIGEFPVYFFGSKDYFWTHQGRVFPYIEGDRG--SRHQRNGIGKVFKTALLEAETRFKQIKMEREAKEAHENNKKPPPYKYIKTNKPCGRVQIYTADISEIPKCNCKPTDERPCSFESECLNRMLLYECHPQVCPAGERCMNQDFTKRLYPETKTIRTAGKGWGLLTLRDIKKGEFVNEYVGELIDEEECRARIRYAQENDITHFYMLTINKDRIIDAGPKGNYSRFMNHSCQPNCETQKWTVNGDTRVGLFAVCDIPTGTELTFNYNLDCLGNEKTVCRCGAP 1211
BLAST of Histone-lysine N-methyltransferase, H3 lysine-36 and H4 lysine-20 specific vs. Ensembl Cavefish
Match: nsd2 (nuclear receptor binding SET domain protein 2 [Source:ZFIN;Acc:ZDB-GENE-030131-2581]) HSP 1 Score: 64.3142 bits (155), Expect = 9.804e-10 Identity = 123/566 (21.73%), Postives = 207/566 (36.57%), Query Frame = 1
Query: 628 CGSYCSWKYHKDCVKDEND----LVCSCNKSVWLCSICCEVINVSQLFVCNNHTCMRPYHRLCL--SAHLDMSPDMKQCPLHSCINCALDYLAEPESKRVQSHLDLVSCVKCKLAFHNIIDCLPTTFIRITRHLIICHRHLVP----SDLLQSNVAQFCFYCSRSISVHNPPVSCKYCLVTYHKCLPCLSGATELLDEHTFICNACKFPYVHRGQCLALALPRETLTNDSVHSW-KLGHLNLVTESTTGNKSVIVTEQTGKKWPTDIH--RTIAINLQSLDHLVS-FGVLRFQDIQYALRDLTKLVERVATSYNLCQNFYRNTFVLRFAGLFPLVENLYYG-----NASTFMDPNQSRPLAKPMK----CDCLEACTTMKCPNVAANAECTDEN-CGAQNRCRNRRL--------------------QKRNFPRSKLLLVDEIGPYVMIDETVVKDVLVGELVGVVKSTAWAEANFQRIGPSNC----VFKLSNEAVIDCSQFCSIFRFIKTSDRPNLQVKIVTVAGFRRIGLFSSHRIVKGDILTLDF--DSLIYRVARDSCGAP 2175
C +C YH C+ ++ L +C V C C + + ++ C+ C + YH CL SA +CPLH+C++C ++ + + ++ C++C +A+H C+ +T I+C H P S NV+ +CF CS+ + + C+ C +H CL+ A + + ++ CN C+ ++ D + W KLG+ WP +I R I N+Q L H + F V F Y ++ + RN F E + A + N+ P K +K C ++ T N + TDE C ++ C NR L KR +P +K + G ++ + K V E VG + A + ++ + ++ + +ID + RF+ S +PN + + TV G R+GLF+ I G LT ++ D L CGAP
Sbjct: 746 CEGHCFATYHLQCLGLDHPTDKVLCTACRTGVHACFTCKQ--SEGEVKRCSVLHCGKYYHEACLRLSALTVFDNRGFRCPLHTCLSCHYSNRGTAKATKGK----MIRCLRCPVAYHAGDLCVAAGSEMLTSTAIVCTNHFNPKKGYSHHSHVNVS-WCFICSKGGRL----LCCESCPAAFHP--DCLNIA---MPDGSWFCNDCRS-------------GKKPKYRDII--WVKLGNYRW--------------------WPAEIRHPRNIPTNIQHLRHEIGEFPVYFFGSKDYFWTHQGRVFPYIEGDRG--SRHQRNGIGKVFKTALLEAETRFKQIKMEREAKEAHENNKKPPPYKYIKTNKPCGRVQIYTADISEIPKCNCKPTDERPCSFESECLNRMLLYECHPQVCPAGERCMNQDFTKRLYPETKTIRTAGKGWGLLTLRDIKKGEFVNEYVGELIDEEECRARIRYAQENDITHFYMLTINKDRIIDAGPKGNYSRFMNHSCQPNCETQKWTVNGDTRVGLFAVCDIPTGTELTFNYNLDCLGNEKTVCRCGAP 1258
BLAST of Histone-lysine N-methyltransferase, H3 lysine-36 and H4 lysine-20 specific vs. Ensembl Cavefish
Match: EZH1 (enhancer of zeste 1 polycomb repressive complex 2 subunit [Source:HGNC Symbol;Acc:HGNC:3526]) HSP 1 Score: 62.7734 bits (151), Expect = 2.053e-9 Identity = 53/178 (29.78%), Postives = 81/178 (45.51%), Query Frame = 1
Query: 1666 CDCLEACTTMKCPNVAANAECTDE---NCGA-------QNRCRNRRLQKRNFPRSKLLLVDEIGPY-VMIDETVVKDVLVGELVGVVKSTAWAEANFQRIGP--SNCVFKLSNEAVIDCSQFCSIFRFIKTSDRPNLQVKIVTVAGFRRIGLFSSHRIVKGDILTLDF-----DSLIY 2145
C C C T +CP A EC + CGA Q C+N +Q R + LL ++ + I E V K+ + E G + S A+ + S+ +F L+N+ V+D ++ + RF S PN K+V V G RIG+F+ I +G+ L D+ D+L Y
Sbjct: 564 CRCKTQCNTKQCPCYLAVRECDPDLCMTCGASDHWDSKQVSCKNCSIQ-RGLKKHLLLAPSDVAGWGTFIKEPVQKNEFISEYCGEIISQDEADRRGRIYDKYMSSFLFNLNNDFVVDATRKGNKIRFANHSVNPNCYAKVVMVNGDHRIGIFAKRAIQQGEELFFDYRYSQADALKY 740
BLAST of Histone-lysine N-methyltransferase, H3 lysine-36 and H4 lysine-20 specific vs. Ensembl Cavefish
Match: EZH1 (enhancer of zeste 1 polycomb repressive complex 2 subunit [Source:HGNC Symbol;Acc:HGNC:3526]) HSP 1 Score: 62.7734 bits (151), Expect = 2.065e-9 Identity = 53/178 (29.78%), Postives = 81/178 (45.51%), Query Frame = 1
Query: 1666 CDCLEACTTMKCPNVAANAECTDE---NCGA-------QNRCRNRRLQKRNFPRSKLLLVDEIGPY-VMIDETVVKDVLVGELVGVVKSTAWAEANFQRIGP--SNCVFKLSNEAVIDCSQFCSIFRFIKTSDRPNLQVKIVTVAGFRRIGLFSSHRIVKGDILTLDF-----DSLIY 2145
C C C T +CP A EC + CGA Q C+N +Q R + LL ++ + I E V K+ + E G + S A+ + S+ +F L+N+ V+D ++ + RF S PN K+V V G RIG+F+ I +G+ L D+ D+L Y
Sbjct: 560 CRCKTQCNTKQCPCYLAVRECDPDLCMTCGASDHWDSKQVSCKNCSIQ-RGLKKHLLLAPSDVAGWGTFIKEPVQKNEFISEYCGEIISQDEADRRGRIYDKYMSSFLFNLNNDFVVDATRKGNKIRFANHSVNPNCYAKVVMVNGDHRIGIFAKRAIQQGEELFFDYRYSQADALKY 736
BLAST of Histone-lysine N-methyltransferase, H3 lysine-36 and H4 lysine-20 specific vs. Ensembl Sea Lamprey
Match: nsd2 (nuclear receptor binding SET domain protein 2 [Source:ZFIN;Acc:ZDB-GENE-030131-2581]) HSP 1 Score: 94.7449 bits (234), Expect = 8.898e-20 Identity = 129/586 (22.01%), Postives = 219/586 (37.37%), Query Frame = 1
Query: 628 CGSYCSWKYHKDCVKDE----NDLVCS-CNKSVWLCSIC-CEVINVSQLFVCNNHTCMRPYHRLCL--SAHLDMSPDMKQCPLHSCINCALDYLAEPESKRVQSHLDLVSCVKCKLAFHNIIDCLPTTFIRITRHLIICHRHLVPS--DLLQSNVAQFCFYCSRSISVHNPP--------VSCKYCLVTYHKC-----------LPCLSGATELLDEHTFICNACKFPYVHRGQCLALALPRETLTNDSVHSWKLGHLNLVTESTTGNKSVIVTEQTGKKWPTDI--HRTIAINLQSLDHLVS-FGVLRFQDIQYALRDLTKLV-----ERVATSYNL-CQNFYRNTFVLRFAGLFPLVENLYYGNASTFMDPNQSRPLA-------KPM--------------KCDCLEACTT-----MKCPNVAANAECTDENCGAQNRCRNRRLQKRNFPRSKLLLVDEIGPYVMIDETVVKDVLVGELVGVVKSTAWAEANFQRIGPSNC----VFKLSNEAVIDCSQFCSIFRFIKTSDRPNLQVKIVTVAGFRRIGLFSSHRIVKGDILTLDF--DSLIYRVARDSCGAP 2175
C C +H +C+ + + ++C+ C+ + +C C C V + C +C R YH C+ S+ +CPLH C++C L Y A + R + + CV+C +A+H CL ++ + I+C H P+ D +CF CSR + P S Y L Y + +P + C +C P +CL + P T + K + + GN + WP +I R I N+Q+L H V F V F Y ++ ++ +T Y C N +L A + ++ + + ++ +P KP+ +C+C + +C N EC C A +RC+N+ KR +P S+++ G ++ ++ K V E VG + + N + + + +ID + RF+ S +PN + + TV G R+GLF++ I G LT ++ D L CGAP
Sbjct: 583 CEGQCCGTFHVECLGVQTAPGDKVMCNECSTGLHVCFACKCAGAEVRR---CAVSSCGRFYHEECVQRSSAAVFEGRRFRCPLHVCLSCHLAYPASSRASRGR----MQRCVRCPVAYHTSDSCLAAGSKVLSPYSIVCSGHFTPNKRDSTWHVNVNWCFLCSRGVIGAPLPDAGLALFEQSSHYLLSEYKRSSELGKLPMIPVVPAAAAKACGKGGCLLCCESC--PAAFHPECLGMEPPEGTWCCAECRAGKKPQYHDIVWVKLGNY---------RWWPAEICQPRNIPQNIQNLKHTVGQFPVQFFGSHDYYWTTQGRVFPYMEGDKGSTDYKTNCLNKTFKRALLEAAARYQALKAQRETREAQETERSERKPPTYKHIKSNKPVGRVQVYTADVSEIPRCNCKPTDESPCGLDSECLNRMLQYECHPSICPAGDRCQNQAFTKRAYPPSQIVKTAGRGWGLLTLVSIRKGEFVNEYVGELIDEEECRKRIKYAHEKNLSNFYMLTIEKDRIIDAGPKGNFSRFMNHSCQPNCETQKWTVNGDTRVGLFATSDIATGTELTFNYNLDCLGNEKTICKCGAP 1150
BLAST of Histone-lysine N-methyltransferase, H3 lysine-36 and H4 lysine-20 specific vs. Ensembl Sea Lamprey
Match: ENSPMAT00000004922.1 (pep scaffold:Pmarinus_7.0:GL479351:23010:32607:-1 gene:ENSPMAG00000004401.1 transcript:ENSPMAT00000004922.1 gene_biotype:protein_coding transcript_biotype:protein_coding) HSP 1 Score: 61.2326 bits (147), Expect = 1.413e-9 Identity = 49/177 (27.68%), Postives = 78/177 (44.07%), Query Frame = 1
Query: 1666 CDCLEACTTMKCPNVAANAECTD---ENCGAQNRCRNRRLQ------KRNFPRSKLLLVDEIGPY-VMIDETVVKDVLVGELVGVVKSTAWAEANFQRIGPSNC--VFKLSNEAVIDCSQFCSIFRFIKTSDRPNLQVKIVTVAGFRRIGLFSSHRIVKGDILTLDF-----DSLIY 2145
C C C T +CP A EC + CGA + NR + +R + LL ++ + + I V K+ + E G + S A+ + C +F L+N+ V+D ++ + RF S PN K++ V G RIG+F+ I G+ L D+ D+L Y
Sbjct: 597 CRCKAQCNTKQCPCYLAVRECDPDLCQTCGAADHWDNRNVSCKNCCIQRGLKKHLLLAPSDVAGWGIFIKVPVQKNEFISEYCGEIISQDEADRRGKVYDKYMCSFLFNLNNDFVVDATRKGNKIRFANHSVSPNCYAKVMMVNGDHRIGIFAKRAIQTGEELFFDYRYSQADALKY 773
BLAST of Histone-lysine N-methyltransferase, H3 lysine-36 and H4 lysine-20 specific vs. Ensembl Sea Lamprey
Match: ENSPMAT00000005461.1 (pep scaffold:Pmarinus_7.0:GL477205:1717:42601:-1 gene:ENSPMAG00000004962.1 transcript:ENSPMAT00000005461.1 gene_biotype:protein_coding transcript_biotype:protein_coding) HSP 1 Score: 49.6766 bits (117), Expect = 5.424e-6 Identity = 60/207 (28.99%), Postives = 87/207 (42.03%), Query Frame = 1
Query: 1642 RPLA--KPMKCDCL------EACTTMKCPNVAANAECTDENCGAQNRCRNRRLQKRNFPRSKLL---LVDEIGPYVMIDETVVKDVLVGELVGVVKSTAWAEANFQRIGPSN-------------CVFKLSNEAVIDCSQFCSIFRFIKTSDRPN--LQVKIVTVAGFRRIGLFSSHRIVKGDILTLDFDSLIYRVARDS---CGAP 2175
+PL+ +P+ C C ++ T C N AEC +C C NRR Q++ RS L + G V + L+ E +G V S EANF+ P + CV +L + VID + + RFI S +PN +Q V+V G RIGLF+ I LT D++ + CG+P
Sbjct: 1107 KPLSGCEPVSCSCKRPEETEDSACTEGCLNRLVYAECVQSSCPCGELCTNRRFQRQE--RSAGLERFRTTDRGWGVRTTHHFQANDLIIEYLGEVLS----EANFRAFAPRSRMLAQRGEQAGMYCV-QLDSGVVIDSYRMGNEARFINHSCQPNCEMQKWCVSVNGIYRIGLFALKDIPISTELTYDYNFHTFTAESQRPCLCGSP 1306
BLAST of Histone-lysine N-methyltransferase, H3 lysine-36 and H4 lysine-20 specific vs. Ensembl Yeast
Match: SET2 (Histone methyltransferase with a role in transcriptional elongation; methylates H3 lysine 36 (H3K36), which suppresses incorporation of acetylated histones and signals for the deacetylation of these histones within transcribed genes; associates with the C-terminal domain(CTD) of Rpo21p; H3K36me3 (trimethylation) requires Spt6p, proline 38 on H3, CTD of Rpo21p, Ctk1p, and C-terminal SRI domain of Ste2p; relocalizes to the cytosol in response to hypoxia [Source:SGD;Acc:S000003704]) HSP 1 Score: 50.0618 bits (118), Expect = 2.459e-6 Identity = 49/187 (26.20%), Postives = 74/187 (39.57%), Query Frame = 1
Query: 1660 MKCDCLE--------ACTT-MKCPNVAANAECTDENCGA-QNRCRNRRLQKRNFPRSKLLLVDEIGPYVMIDETVVKDVLVGELVGVVKSTAWAEANF--------QRIGPSNCVFKLSNEAVIDCSQFCSIFRFIKTSDRPNLQVKIVTVAGFRRIGLFSSHRIVKGDILTLDFDSLIYRVARDSC 2166
M+CDC E AC C N EC ++ C + N C+N+R QK+ + + G V ++ + + + E G V E F QR L N ID + S+ RF S PN V V R+G+F+ +I+KG+ +T D++ Y C
Sbjct: 66 MECDCYEEFSDGVNHACDEDSDCINRLTLIECVNDLCSSCGNDCQNQRFQKKQYAPIAIFKTKHKGYGVRAEQDIEANQFIYEYKGEV----IEEMEFRDRLIDYDQRHFKHFYFMMLQNGEFIDATIKGSLARFCNHSCSPNAYVNKWVVKDKLRMGIFAQRKILKGEEITFDYNVDRYGAQAQKC 248
BLAST of Histone-lysine N-methyltransferase, H3 lysine-36 and H4 lysine-20 specific vs. Ensembl Nematostella
Match: EDO43156 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7RZJ4]) HSP 1 Score: 97.0561 bits (240), Expect = 1.824e-20 Identity = 121/536 (22.57%), Postives = 208/536 (38.81%), Query Frame = 1
Query: 628 CGSYCSWKYHKDCVK----DENDLVC-SCNKSVWLCSICCEVINVSQLFVCNNHTCMRPYHRLCLSAHL--DMSPDMKQCPLHSCINCALDYLAEPESKRVQSHLDLVSCVKCKLAFHNIIDCLPTTFIRITRHLIICHRHLVP--SDLLQSNV-AQFCFYCSRSISVHNPPVSCKYCLVTYHKCLPCLSGATELLDEHTFICNACKFPYVHRGQCLALALPRETLTNDSVHSWKLGHLNLVTESTTGNKSVIVTEQTGKKWPTD-------------IHRTIAINLQSLDHLVSFGVLRFQDIQYALRDLTKLVERVATSYNLCQNFYRNTF---VLRFAGLFPLVENLYYGNAST----FMDPNQSRPLAKPMKCDCL--EACTT-MKCPNVAANAECTDENCGAQNRCRNRRLQKRNFPRSKLLLVDEIGPYVMIDETVVKDVLVGELVGVVKSTAWAEANFQRIGPSNCVFKLS--NEAVIDCSQFCSIFRFIKTSDRPNLQVKIVTVAGFRRIGLFSSHRIVKGDILTLDF 2130
CG C+ YH DC+ + C C V C +C + +V C+ C + YH+ CL ++ + D CPLH C C +K + L C++C A+H CL + IT HL++C +H +P S ++V +CF CS ++ + C+ C +H C+S E + E F C C + ++L + KLG + V Q+ + P + IH+ + Q D G + +Y + K + Y+ + + + RF P +++ +T +DP++ P+ C+C +AC C N+ EC C A ++C+N+R QKR + + G + + + K V E VG + A ++ + L+ + +ID ++ RF+ S PN + + TV G R+GLF+S + + LT D+
Sbjct: 3 CGD-CNSAYHPDCIGLSTAPKGKFKCDECTSGVHSCFVCRQTGDVK---ACSQPLCSKFYHKECLQSYKCSKIDGDRIYCPLHFCSTCI-------SNKTPVNRGRLTKCIRCPTAYH--AGCLVAGCMPITSHLMVCAKHFLPNKSKAHHTHVNVNWCFVCSIGGTL----ICCESCPAAFHP--ECIS--YEGIPEGRFYCKDC--------------VEGKSLLYGDIVWVKLGMYRWWPAMICNPRDVPTNIQSMRHQPGEFPVMFLGSHDFYWIHKGRVFSYQDGDKGTESG-----NNKYLAKVFKKALVEAKEKYDEWKKAREDKAEQDLQRFCKKPPQYKHIKTNKCTTAQRIILDPSE-MPV-----CECTPDQACGQDANCLNLMLQFECVASRCPAGDKCQNQRFQKRQYVDCEPFRAHSRGWGLRSKQAIKKGTFVIEYVGELIDDATCRERVKKGDDDTNYYMLTIDKDCIIDAGPMGNLSRFMNHSCYPNCETQKWTVNGEVRVGLFTSRDVESQEELTFDY 492
BLAST of Histone-lysine N-methyltransferase, H3 lysine-36 and H4 lysine-20 specific vs. Ensembl Nematostella
Match: EDO30322 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7T142]) HSP 1 Score: 66.6254 bits (161), Expect = 4.416e-11 Identity = 50/166 (30.12%), Postives = 74/166 (44.58%), Query Frame = 1
Query: 1666 CDCLEACTTMKCPNVAANAECTDE---NCGAQN------RCRNRRLQKRNFPRSKLLLVDEIGPYVMIDETVVKDVLVGELVGVVKSTAWAEANFQRIGPSNC--VFKLSNEAVIDCSQFCSIFRFIKTSDRPNLQVKIVTVAGFRRIGLFSSHRIVKGDILTLDF 2130
C C C T +CP A EC + CGA N C+N LQ+ L D G + I ++V K+ + E G V S A+ + C +F L+N+ V+D ++ + RF S PN K++ V G RIG+F+ I G+ L D+
Sbjct: 501 CRCKAQCNTKQCPCFLAVRECDPDLCGTCGADNFDQDSKTCKNVSLQRGQRKHMLLAPSDVAGWGIYIKQSVKKNEFISEYCGEVISQDEADRRGKVYDKYMCSFLFNLNNDFVVDATRKGNKIRFANHSISPNCYAKVMMVNGDHRIGIFAKRDIEAGEELFFDY 666
BLAST of Histone-lysine N-methyltransferase, H3 lysine-36 and H4 lysine-20 specific vs. Ensembl Medaka
Match: nsd3 (nuclear receptor binding SET domain protein 3 [Source:NCBI gene;Acc:101156018]) HSP 1 Score: 87.4261 bits (215), Expect = 8.732e-17 Identity = 131/579 (22.63%), Postives = 216/579 (37.31%), Query Frame = 1
Query: 628 CGSYCSWKYHKDCVK----DENDLVC-SCNKSVWLCSICCEVINVSQLFVCNNHTCMRPYHRLCLSAHLDMSPDMKQ---CPLHSCINCALDYLAEPESKRVQSHLDLVSCVKCKLAFHNIIDCLPTTFIRITRHLIICHRH--LVPSDLLQSNV-AQFCFYCSRSISVHN--------PPVSCKYCLVTYHKC------LPCLSGATEL---LDEHTFICNACKFPYVHRGQCLALALPRETLTNDSVHSWKLGHLNLVTESTTGNKSVIVTEQTGKKWPTDI--HRTIAINLQSLDHLVS-FGVLRFQDIQYALRDLTKLVERVATSYNLCQN------FYRNTF---VLRFAGLFPLVEN---LYYGNASTFMDP----NQSRPLAKPM----------KCDCL----EACT-TMKCPNVAANAECTDENCGAQNRCRNRRLQKRNFPRSKLLLVDEIGPYVMIDETVVKDVLVGELVGVVKSTAWAEANFQRIGPSNC----VFKLSNEAVIDCSQFCSIFRFIKTSDRPNLQVKIVTVAGFRRIGLFSSHRIVKGDILTLDFDSLIYRVARDSC 2166
C CS ++H +C+ + C C S C C ++ C+ C YH C+ H + CP HSC C L+ + SK L+ C++C A+H C+ + +T H++IC H + LL S V +CF C+R + V + Y L ++ +P S AT+ C++C P +CL + +P + + K H + GN + WP +I R + N+QSL H + F V F Y + ++ V N ++N RF L E+ L S P ++P+ K +C+C C+ +C N EC + C A + C N+ KR + ++++ + G + ++ + K V E VG V + + +R ++ + L+ + VID + RFI S PN + + TV G RIG+F+ I G LT +++ R SC
Sbjct: 869 CEGDCSRQFHPECLGLSAPPDGRFTCLECKNSNHPCFSC--KTTGQEVSRCSAPGCSCYYHEDCVWKHPGTTSSPGGGFCCPQHSCSTCCLERDLQRASKG-----RLIHCIRCPTAYHTSDVCMAAGSVILTHHIMICSNHGSTKKNGLLSSPVNVGWCFLCARGLLVQDLTDTILSSYAYKSHYLLTESNRAELKLPMIPSPSSATKKNVGKGGKLLCCDSC--PASFHPECLEMDMPEGAWSCSDCRAGKKPHYKQIVWVKLGNY---------RWWPAEICNPRLVPSNIQSLRHDIGDFPVFFFGSHDYYWINQGRVFPYVENDKNFVTGQININKTFKNALEEAARRFQELKAQRESREALEQERNSRKPPPYKVIKSNKPVGKVQMHVADLSEIPRCNCKPVDEHPCSIDSQCLNRMLQYECHPQVCPAGDNCENQNFTKRLYAETEVVKTEGRGWGLQTNQALRKGDFVAEYVGEVIDSEECQQRIKRAHENHVTNFYMLTLTKDRVIDAGPKGNSARFINHSCNPNCETQKWTVNGDVRIGIFALCDIEAGTELTFNYNLHCVGNRRTSC 1429
BLAST of Histone-lysine N-methyltransferase, H3 lysine-36 and H4 lysine-20 specific vs. Ensembl Medaka
Match: nsd3 (nuclear receptor binding SET domain protein 3 [Source:NCBI gene;Acc:101156018]) HSP 1 Score: 85.8853 bits (211), Expect = 2.687e-16 Identity = 124/562 (22.06%), Postives = 205/562 (36.48%), Query Frame = 1
Query: 628 CGSYCSWKYHKDCVK----DENDLVC-SCNKSVWLCSICCEVINVSQLFVCNNHTCMRPYHRLCLSAHLDMSPDMKQ---CPLHSCINCALDYLAEPESKRVQSHLDLVSCVKCKLAFHNIIDCLPTTFIRITRHLIICHRH--LVPSDLLQSNV-AQFCFYCSRSISVHNPPVSCKYCLVTYHKCLPCLSGATELLDEHTFICNACKFPYVHRGQCLALALPRETLTNDSVHSWKLGHLNLVTESTTGNKSVIVTEQTGKKWPTDI--HRTIAINLQSLDHLVS-FGVLRFQDIQYALRDLTKLVERVATSYNLCQN------FYRNTF---VLRFAGLFPLVEN---LYYGNASTFMDP----NQSRPLAKPM----------KCDCL----EACT-TMKCPNVAANAECTDENCGAQNRCRNRRLQKRNFPRSKLLLVDEIGPYVMIDETVVKDVLVGELVGVVKSTAWAEANFQRIGPSNC----VFKLSNEAVIDCSQFCSIFRFIKTSDRPNLQVKIVTVAGFRRIGLFSSHRIVKGDILTLDFDSLIYRVARDSC 2166
C CS ++H +C+ + C C S C C ++ C+ C YH C+ H + CP HSC C L+ + SK L+ C++C A+H C+ + +T H++IC H + LL S V +CF C+R + + C C ++H +CL + +P + + K H + GN + WP +I R + N+QSL H + F V F Y + ++ V N ++N RF L E+ L S P ++P+ K +C+C C+ +C N EC + C A + C N+ KR + ++++ + G + ++ + K V E VG V + + +R ++ + L+ + VID + RFI S PN + + TV G RIG+F+ I G LT +++ R SC
Sbjct: 869 CEGDCSRQFHPECLGLSAPPDGRFTCLECKNSNHPCFSC--KTTGQEVSRCSAPGCSCYYHEDCVWKHPGTTSSPGGGFCCPQHSCSTCCLERDLQRASKG-----RLIHCIRCPTAYHTSDVCMAAGSVILTHHIMICSNHGSTKKNGLLSSPVNVGWCFLCARGGKL----LCCDSCPASFHP------------------------------ECLEMDMPEGAWSCSDCRAGKKPHYKQIVWVKLGNY---------RWWPAEICNPRLVPSNIQSLRHDIGDFPVFFFGSHDYYWINQGRVFPYVENDKNFVTGQININKTFKNALEEAARRFQELKAQRESREALEQERNSRKPPPYKVIKSNKPVGKVQMHVADLSEIPRCNCKPVDEHPCSIDSQCLNRMLQYECHPQVCPAGDNCENQNFTKRLYAETEVVKTEGRGWGLQTNQALRKGDFVAEYVGEVIDSEECQQRIKRAHENHVTNFYMLTLTKDRVIDAGPKGNSARFINHSCNPNCETQKWTVNGDVRIGIFALCDIEAGTELTFNYNLHCVGNRRTSC 1380
BLAST of Histone-lysine N-methyltransferase, H3 lysine-36 and H4 lysine-20 specific vs. Ensembl Medaka
Match: ENSORLT00000006947.2 (histone-lysine N-methyltransferase, H3 lysine-36 and H4 lysine-20 specific [Source:NCBI gene;Acc:101160669]) HSP 1 Score: 82.4185 bits (202), Expect = 3.215e-15 Identity = 126/562 (22.42%), Postives = 219/562 (38.97%), Query Frame = 1
Query: 628 CGSYCSWKYHKDCVK----DENDLVC-SCNKSVWLCSICCEVINVSQLFVCNNHTCMRPYHRLCLSAHLDMSPDMK--QCPLHSCINCALDYLAEPESKRVQSHLDLVSCVKCKLAFHNIIDCLPTTFIRITRHLIICHRHLVPSDLLQS----NVAQFCFYCSRSISVHNPPVSCKYCLVTYHKCLPCLSGATELLDEHTFICNACKFP---------YVHRGQ--------CLALALPRETLTNDSVHSWKLGH-LNLVTESTTGNKSVIVTEQTGKKWP---TDIHRTIAINLQS---LDHLVSFGVLRFQDIQYALRDLTKLVERVATSYNLCQNFYRNTFVLRFAGLFPLVENLYYGNASTFMDPNQSRPLAKPMKCDCLEA-----CTTMKCPNVAANAECTDENCGAQNRCRNRRLQKRNFPRSKLLLVDEIGPYVMIDETVVKDVLVGELVGVVKSTAWAEANFQRIGPSNC----VFKLSNEAVIDCSQFCSIFRFIKTSDRPNLQVKIVTVAGFRRIGLFSSHRIVKGDILTLDFDSLIYRVARD--SCGAP 2175
C +C +H CV + C CN +C +C + +V + + C + YH C+ A P K +CPLH C++C ++ P + S L CV+C +A+H +C+ + + + +C H P ++ NV+ +CF CS S+ + C+ C +H+ CL+ + + ++ CN CK +V G+ CLA +P L ++ H + G+K + T Q + +P D H + + +S RF+++Q R++ +L E YR+ V R G ++ + L++ +C+C + +C N EC + C A RC+N+ KR + ++ G + + K V E VG V A + + + L + VID + RF+ S +PN + + TV G R+GLF+ I KG+ LT +++ + CGAP
Sbjct: 1247 CEGHCYGAFHLQCVGLSVAPKGKFFCQECNTGDHMCFVCKKSGDVKRCII---PLCGKFYHMDCILAFSATQPHNKGFRCPLHVCLSC---HITNPVNV-FSSKGRLARCVRCPVAYHANDNCMAAGSVVLDNNTFLCPNHFTPRKGCKNHEHINVS-WCFVCSEGGSL----LCCEACPAAFHR--ECLNIE---MPQGSWFCNDCKAGKKPRIKDILWVKWGRYRWWPAEVCLARDVPNNIL--------RMKHEVGEFPVQFFGSKDFVWTYQA-RVFPYMEGDTHNIEKMGKGADAIYKKALSEAAERFKELQTE-REMKQLQEDRKNDKKPPP--YRHIKVNRPIGKVQII----------------TADLSEVPRCNCKASDENPCGADSECINRMLMYECHPQVCAAGERCQNQAFTKRQYTTVEIYRTLSCGWGLRAVSDIKKGAFVSEYVGEVIDEEECRARIRHAQEHDICNFYMLTLDKDRVIDAGPKGNQARFMNHSCQPNCETQKWTVNGDTRVGLFALQDIAKGEELTFNYNLECRGNGKTVCKCGAP 1763
BLAST of Histone-lysine N-methyltransferase, H3 lysine-36 and H4 lysine-20 specific vs. Ensembl Medaka
Match: nsd2 (nuclear receptor binding SET domain protein 2 [Source:NCBI gene;Acc:101172132]) HSP 1 Score: 80.8777 bits (198), Expect = 6.846e-15 Identity = 140/621 (22.54%), Postives = 232/621 (37.36%), Query Frame = 1
Query: 460 SQTKDFESHPCEICLIKEVEFDCGTKNQYLTTMNENEQRKYFSRLMLTDNNNRNTKCGSYCSWKYHKDCV----KDENDLVCS-CNKSVWLCSICCEVINVSQLFVCNNHTCMRPYHRLCLSAHLDMSPDMK--QCPLHSCINCALDYLAEPESKRVQSHLDLVSCVKCKLAFHNIIDCLPTTFIRITRHLIICHRHLVP----SDLLQSNVAQFCFYCSRSISVHNPPVSCKYCLVTYHKCLPCLSGATELLDEHTFICNACKFPYVHRGQCLALALPRETLTNDSVHSW-KLGHLNLVTESTTGNKSVIVTEQTGKKWPTDIH--RTIAINLQSLDHLVS-FGVLRFQDIQYALRDLTKLVERVATSYNLCQN------FYRNTFV---LRFAGLFPLVENLYYGNASTFMDPNQ----SRPLAKPM----------KCDCL----EACT-TMKCPNVAANAECTDENCGAQNRCRNRRLQKRNFPRSKLLLVDEIGPYVMIDETVVKDVLVGELVGVVKSTAWAEANFQRIGPSNC----VFKLSNEAVIDCSQFCSIFRFIKTSDRPNLQVKIVTVAGFRRIGLFSSHRIVKGDILTLDF--DSLIYRVARDSCGAP 2175
S+ K S PC E + + L + E+RK F + C C +H C+ K E+ L+C C + C C + + ++ C+ C + YH C+ + D K +CPLH+C++C + +S + + L+ C++C +A+H C+ IT I+C H S NV+ +CF CS+ + + C+ C +H CL+ A + + ++ CN C+ A PR D + W KLG T + WP +I R I N+Q L H + F V F Y ++ + ++N + RF + E +S P + +RP + KC+C C +C N EC + C + RC N+ KR +P +K++ G ++ + K V E +G + A + +N + + + +ID + RF+ S +PN + + TV G R+GLF+ I G LT ++ D L CGAP
Sbjct: 535 SKAKKRRSSPCPDAEGSGSEERPDSPSDSLDGTKKGEKRKEFVCQVCEQAGEDLVPCEGQCCGMFHLHCLGPSFKPEDKLLCQQCRAGIHSCFACKQ--SEGEVRRCHVVHCGKFYHEACIRLNPLTVFDNKGLRCPLHACLSCHYGSRTKHKSTKGR----LMRCLRCPVAYHVGDLCVAAGSEMITNTAIVCTNHFNAKKGYSHHSHVNVS-WCFVCSKGGQL----LCCESCPAAFHP--DCLNIA---MPDGSWYCNDCR----------AGKKPR---YRDII--WVKLG--------------------TYRWWPAEIQHPRNIPTNIQHLRHEIGEFPVFFFGSRDYFWTHQGRVFPYMEGDRGSKHQRTGIGRVFKNALLEAEARFKEMKMKREAKEAQESSRKPPPYKFIKVNRPYGRVQVYTADVSEIPKCNCKPTDERPCGFESECLNRMLQYECHPQVCPSGERCCNQDFTKRLYPETKIIKTPGKGWGLVALRDIKKGKFVNEYIGELIDEEECRARIKYAHENNITNFYMLTIDKDRIIDAGPKGNYSRFMNHSCQPNCETQKWTVNGDTRVGLFAVCHIPAGTELTFNYNLDCLGNEKTICRCGAP 1104
BLAST of Histone-lysine N-methyltransferase, H3 lysine-36 and H4 lysine-20 specific vs. Ensembl Medaka
Match: ezh1 (enhancer of zeste 1 polycomb repressive complex 2 subunit [Source:NCBI gene;Acc:101166385]) HSP 1 Score: 62.7734 bits (151), Expect = 2.094e-9 Identity = 52/178 (29.21%), Postives = 82/178 (46.07%), Query Frame = 1
Query: 1666 CDCLEACTTMKCPNVAANAECTDE---NCGAQNR-------CRNRRLQKRNFPRSKLLLVDEIGPY-VMIDETVVKDVLVGELVGVVKSTAWAEANFQRIGP--SNCVFKLSNEAVIDCSQFCSIFRFIKTSDRPNLQVKIVTVAGFRRIGLFSSHRIVKGDILTLDF-----DSLIY 2145
C C C T +CP A EC + CGA + C+N +Q R + LL ++ + I E V K+ + E G + S A+ + S+ +F L+N+ V+D ++ + RF S PN K+V V G RIG+F+ I++G+ L D+ D+L Y
Sbjct: 508 CRCKTQCNTKQCPCYLAVRECDPDLCMTCGAADHWDSKVVTCKNCSIQ-RGLKKHLLLAPSDVAGWGTFIKEPVQKNEFISEYCGELISQDEADRRGRIYDKYMSSFLFNLNNDFVVDATRKGNKIRFANHSVNPNCYAKVVMVNGDHRIGIFAKRAILQGEELFFDYRYSQADALKY 684
BLAST of Histone-lysine N-methyltransferase, H3 lysine-36 and H4 lysine-20 specific vs. Planmine SMEST
Match: SMESG000032555.1 (SMESG000032555.1) HSP 1 Score: 1696.79 bits (4393), Expect = 0.000e+0 Identity = 814/819 (99.39%), Postives = 817/819 (99.76%), Query Frame = 1
Query: 79 MISHQFSEGECIIGKLGTNPWWPGMIKECNNKNQAFVKFFEINIESWIDTNSIIHCSSREEMEQYLNSISKTTSNNKYLNYIPSAMVDLYNEAWKTFDSKQNLYTHKDNKNSTNDVVLNKVQSHRGKSQTKDFESHPCEICLIKEVEFDCGTKNQYLTTMNENEQRKYFSRLMLTDNNNRNTKCGSYCSWKYHKDCVKDENDLVCSCNKSVWLCSICCEVINVSQLFVCNNHTCMRPYHRLCLSAHLDMSPDMKQCPLHSCINCALDYLAEPESKRVQSHLDLVSCVKCKLAFHNIIDCLPTTFIRITRHLIICHRHLVPSDLLQSNVAQFCFYCSRSISVHNPPVSCKYCLVTYHKCLPCLSGATELLDEHTFICNACKFPYVHRGQCLALALPRETLTNDSVHSWKLGHLNLVTESTTGNKSVIVTEQTGKKWPTDIHRTIAINLQSLDHLVSFGVLRFQDIQYALRDLTKLVERVATSYNLCQNFYRNTFVLRFAGLFPLVENLYYGNASTFMDPNQSRPLAKPMKCDCLEACTTMKCPNVAANAECTDENCGAQNRCRNRRLQKRNFPRSKLLLVDEIGPYVMIDETVVKDVLVGELVGVVKSTAWAEANFQRIGPSNCVFKLSNEAVIDCSQFCSIFRFIKTSDRPNLQVKIVTVAGFRRIGLFSSHRIVKGDILTLDFDSLIYRVARDSCGAPTDTPARLETWKEALVAPANPMAEELFVIDLCGDDADQIRDDSMDTETIAGRAPLCPECLKELMMPQSRPRVLIHCRICYSVFHYRCACLSIELNDALCNRLEQEARIQNFICQVCTAMRP 2535
MISHQFSEGECIIGKLGTNPWWPGMIKECNNKNQAFVKFFEINIESWIDTNSIIHCSSREEMEQYLNSISKTTSNNKYLNYIPSAMVDLYNEAWKTFDSKQNLYTHKDNKNSTNDVVLNKVQSHRGKSQTKDFESHPCEICLIKEVEFDCGTKNQYLTTMNENEQRKYFSRLMLTDNNNRNTKCGSYCSWKYHKDCVKDENDLVCSCNKSVWLCSICCEVINVSQLFVCNNHTCMRPYHR CLSAHLDMSPDMKQCPLHSCINCALDYLAEPESKRVQSHLDLVSCVKCKLAFHNIIDCLPTTFIRITRHLIICHRHLVPSDLLQSNVAQFCFYCSRSISVHNPPVSCKYCLVTYHKCLPCLSGATELLDEHTFICNACKFPYVHRGQCLALALPRETLT+DSVHSWKLGHLNLVTESTTGNKSVIVTEQTGKKWPTDIHRTI+INLQSLDHLVSFGVLRFQDIQYALRDLTKLVERVATSYNLCQNFYRN FVLRFAGLFPLVENLYYGNASTFMDPNQSRPLA+PMKCDCLEACTTMKCPNVAANAECTDENCGAQNRCRNRRLQKRNFPRSKLLLVDEIGPYVMIDETVVKDVLVGELVGVVKSTAWAEANFQRIGPSNCVFKLSNEAVIDCSQFCSIFRFIKTSDRPNLQVKIVTVAGFRRIGLFSSHRIVKGDILTLDFDSLIYRVARDSCGAPTDTPARLETWKEALVAPANPMAEELFVIDLCGDDADQIRDDSMDTETIAGRAPLCPECLKELMMPQSRPRVLIHCRICYSVFHYRCACLSIELNDALCNRLEQEARIQNFICQVCTAMRP
Sbjct: 1 MISHQFSEGECIIGKLGTNPWWPGMIKECNNKNQAFVKFFEINIESWIDTNSIIHCSSREEMEQYLNSISKTTSNNKYLNYIPSAMVDLYNEAWKTFDSKQNLYTHKDNKNSTNDVVLNKVQSHRGKSQTKDFESHPCEICLIKEVEFDCGTKNQYLTTMNENEQRKYFSRLMLTDNNNRNTKCGSYCSWKYHKDCVKDENDLVCSCNKSVWLCSICCEVINVSQLFVCNNHTCMRPYHRSCLSAHLDMSPDMKQCPLHSCINCALDYLAEPESKRVQSHLDLVSCVKCKLAFHNIIDCLPTTFIRITRHLIICHRHLVPSDLLQSNVAQFCFYCSRSISVHNPPVSCKYCLVTYHKCLPCLSGATELLDEHTFICNACKFPYVHRGQCLALALPRETLTSDSVHSWKLGHLNLVTESTTGNKSVIVTEQTGKKWPTDIHRTISINLQSLDHLVSFGVLRFQDIQYALRDLTKLVERVATSYNLCQNFYRNAFVLRFAGLFPLVENLYYGNASTFMDPNQSRPLAEPMKCDCLEACTTMKCPNVAANAECTDENCGAQNRCRNRRLQKRNFPRSKLLLVDEIGPYVMIDETVVKDVLVGELVGVVKSTAWAEANFQRIGPSNCVFKLSNEAVIDCSQFCSIFRFIKTSDRPNLQVKIVTVAGFRRIGLFSSHRIVKGDILTLDFDSLIYRVARDSCGAPTDTPARLETWKEALVAPANPMAEELFVIDLCGDDADQIRDDSMDTETIAGRAPLCPECLKELMMPQSRPRVLIHCRICYSVFHYRCACLSIELNDALCNRLEQEARIQNFICQVCTAMRP 819
BLAST of Histone-lysine N-methyltransferase, H3 lysine-36 and H4 lysine-20 specific vs. Planmine SMEST
Match: SMESG000039925.1 (SMESG000039925.1) HSP 1 Score: 72.7886 bits (177), Expect = 1.380e-12 Identity = 49/167 (29.34%), Postives = 77/167 (46.11%), Query Frame = 1
Query: 1690 TMKCPNVAANAECTDENCGAQNRCRNRRLQKRNFPRSKLLLVDEIGPYVMIDETVVKDVLVGELVGVVKSTAWAEANFQRIGPSNC----VFKLSNEAVIDCSQFCSIFRFIKTSDRPNLQVKIVTVAGFRRIGLFSSHRIVKGDILTLDFD--SLIYRVARDSCGA 2172
T +C N EC C CRN+R +R +P+ ++ D G + E + K V E VG + A A ++ +N + +L + +ID +I RF+ S PN+ + +V G RIGLF+ H I G+ LT +++ SL + CGA
Sbjct: 763 TSECMNRELMYECHPLVCRNGENCRNQRFMRREYPKQEVFSTDNRGWALRTLEPIKKGAFVNEYVGELIDEAEANRRLKKAHETNVSNFYMMELDGQRIIDAGPAANISRFMNHSCSPNVYTQKWSVNGDTRIGLFALHTIKAGEELTFNYNFFSLGQKKLPCKCGA 929 HSP 2 Score: 71.633 bits (174), Expect = 3.948e-12 Identity = 86/378 (22.75%), Postives = 155/378 (41.01%), Query Frame = 1
Query: 85 SHQFSEGECIIGKLGTNPWWPGMI---------KECNNKNQAFVKFFEINIE-SWIDTNSIIHCSSREEMEQYLNSISKTTSNNKYLNY--IPSAMVDLYNEAWKTFDS--------KQNLYTHKDNKNSTNDVVLNKVQSHRGKSQTKDFESHPCEICLIKEVEFDCGTKNQYLTTMNENEQRKYFSRLMLTDN----NNRNTKCGSYCSWKYHKDCVKDENDLVCS---------------CNKSVWLCSICCEVIN---VSQLFVCNNHTCMRPYHRLCL-SAHLDMSPDMKQ-----CPLHSCINCALDYLAEPES-KRVQSHLDLVSCVKCKLAFHNIIDCLPTTFIRITRHLIICHRHLVPSDLLQSNVAQF 1071
S ++ G + K+ ++PWWP MI KE +K V +F ++ W+ NS++ + + + ++ +++ S + IP + + +++E+WK + + ++Y + N+ + + D +S PC+ I F+ +N L T + N ++ L L +N NN C C ++H DC++ D + S CN++V C IC ++ ++ C+ C R YH CL + H + CP H C C Y+ +PE+ K+ +H V C+ C +FH C+P I + IIC +HL + V F
Sbjct: 131 SEEYYVGRLLWAKVKSHPWWPCMIYYSPEKNFYKEMFHKKVIHVAYFGPYVQRGWVSINSVMSFEGKLKFDDHVKELTENNSPKNIIQKYTIPQSRMKIFSESWKEAEEAMMMPVKDRIDVYGISYKNLNGESSSENEEKISEEEFDESDMDSSPCKKQKIVAETFE--FQNLKLPTFS-NCKKNPLCFLCLEENDESGNNLVANCTGGCGQQFHPDCLRLLFDYLTSKEPTTKVINYLKCVDCNRNVRRCFICQKLGKNDKKDEMMKCSTSNCGRYYHSNCLYNGHYQQLITYNRSGSLTCPSHICHAC---YIDDPEAVKQCSNH---VRCLMCPSSFHKGDWCIPAGSKEINDNYIICPKHLSMGGSAEITVTPF 499
BLAST of Histone-lysine N-methyltransferase, H3 lysine-36 and H4 lysine-20 specific vs. Planmine SMEST
Match: SMESG000039925.1 (SMESG000039925.1) HSP 1 Score: 72.7886 bits (177), Expect = 1.484e-12 Identity = 49/167 (29.34%), Postives = 77/167 (46.11%), Query Frame = 1
Query: 1690 TMKCPNVAANAECTDENCGAQNRCRNRRLQKRNFPRSKLLLVDEIGPYVMIDETVVKDVLVGELVGVVKSTAWAEANFQRIGPSNC----VFKLSNEAVIDCSQFCSIFRFIKTSDRPNLQVKIVTVAGFRRIGLFSSHRIVKGDILTLDFD--SLIYRVARDSCGA 2172
T +C N EC C CRN+R +R +P+ ++ D G + E + K V E VG + A A ++ +N + +L + +ID +I RF+ S PN+ + +V G RIGLF+ H I G+ LT +++ SL + CGA
Sbjct: 778 TSECMNRELMYECHPLVCRNGENCRNQRFMRREYPKQEVFSTDNRGWALRTLEPIKKGAFVNEYVGELIDEAEANRRLKKAHETNVSNFYMMELDGQRIIDAGPAANISRFMNHSCSPNVYTQKWSVNGDTRIGLFALHTIKAGEELTFNYNFFSLGQKKLPCKCGA 944 HSP 2 Score: 67.3958 bits (163), Expect = 7.074e-11 Identity = 85/390 (21.79%), Postives = 156/390 (40.00%), Query Frame = 1
Query: 85 SHQFSEGECIIGKLGTNPWWPGMI---------KECNNKNQAFVKFFEINIE-SWIDTNSIIHCSSREEMEQYLNSISKTTSNNKYLNY--IPSAMVDLYNEAWKTFDS--------KQNLYTHKDNKNSTNDVVLNKVQSHRGKSQTKDFESHPCEIC-LIKEVEFDCGTKNQYLTTMN---ENEQRKYFSR--------LMLTDN----NNRNTKCGSYCSWKYHKDCVKDENDLVCS---------------CNKSVWLCSICCEVIN---VSQLFVCNNHTCMRPYHRLCL-SAHLDMSPDMKQ-----CPLHSCINCALDYLAEPES-KRVQSHLDLVSCVKCKLAFHNIIDCLPTTFIRITRHLIICHRHLVPSDLLQSNVAQF 1071
S ++ G + K+ ++PWWP MI KE +K V +F ++ W+ NS++ + + + ++ +++ S + IP + + +++E+WK + + ++Y + N+ + + D +S PC+ ++ E ++ +N +N + FS L L +N NN C C ++H DC++ D + S CN++V C IC ++ ++ C+ C R YH CL + H + CP H C C Y+ +PE+ K+ +H V C+ C +FH C+P I + IIC +HL + V F
Sbjct: 131 SEEYYVGRLLWAKVKSHPWWPCMIYYSPEKNFYKEMFHKKVIHVAYFGPYVQRGWVSINSVMSFEGKLKFDDHVKELTENNSPKNIIQKYTIPQSRMKIFSESWKEAEEAMMMPVKDRIDVYGISYKNLNGESSSENEEKISEEEFDESDMDSSPCKKQKIVAETALTIVYIGRFSIVLNFEFQNLKLPTFSNCKKNPLCFLCLEENDESGNNLVANCTGGCGQQFHPDCLRLLFDYLTSKEPTTKVINYLKCVDCNRNVRRCFICQKLGKNDKKDEMMKCSTSNCGRYYHSNCLYNGHYQQLITYNRSGSLTCPSHICHAC---YIDDPEAVKQCSNH---VRCLMCPSSFHKGDWCIPAGSKEINDNYIICPKHLSMGGSAEITVTPF 514
BLAST of Histone-lysine N-methyltransferase, H3 lysine-36 and H4 lysine-20 specific vs. Planmine SMEST
Match: SMESG000015015.1 (SMESG000015015.1) HSP 1 Score: 71.2478 bits (173), Expect = 4.096e-12 Identity = 44/149 (29.53%), Postives = 70/149 (46.98%), Query Frame = 1
Query: 1699 CPNVAANAECTDENCGAQNRCRNRRLQKRNFPRSKLLLVDEIGPYVMIDETVVKDVLVGELVGVVKSTAWAEANFQRIGPSNC----VFKLSNEAVIDCSQFCSIFRFIKTSDRPNLQVKIVTVAGFRRIGLFSSHRIVKGDILTLDFD 2133
C NVA+ EC + C ++C+N+ KR +P+ ++ G + DE + V E +G + + +E +N +L N +ID QF ++ RFI S PNL + V RIGLF+ I KG+ LT ++
Sbjct: 609 CFNVASKCECDPQICNLGDKCKNQNFVKRIYPKQYTFWANDRGWGLKADEFIKTKQFVNEYIGEIITMEESEKRILWANENNISDFYFMELDNGRLIDARQFSNLSRFINNSCDPNLVAEKWIVNREHRIGLFALRDIQKGEELTFQYN 757 HSP 2 Score: 52.373 bits (124), Expect = 2.894e-6 Identity = 86/358 (24.02%), Postives = 144/358 (40.22%), Query Frame = 1
Query: 85 SHQFSEGECIIGKLGTNPWWPGMIKE--CNNKNQAFVKFF-EINIESWIDTNSIIHCSSREEMEQYL---NSISKTTSNNKYLNYIPSAMVDLYNEAWKTFD--------SKQNLYTHK-DNKNSTNDVVLNKVQSHRGKSQTKDFESHPCEICLIKEVEFDCGTKNQYLTTMNENEQRKYFSRLMLTDNNNRN-------TKCGSYCSWKYHKDCVK----------DENDLVCSCNKSVWLCSICCEVINVS--QLFV-CNNHTCMRPYHRLCLSAH--LDMS----PDMKQCPLHSCINCALDYLAEPESKRVQSHLDLVSCVKCKLAFHNIIDCLPTTFIRITRHLIICHRHLV 1035
S + G+ I GK+G PWWP M+ +N+ + V +F + N S++ + ++ ++ + E N KT + + +Y +DL AWK + S+ LY K + K S N K + K + + S P EI + +++ +E F + LT+ N R +C +H C++ ++ D C+ + C C +++++S Q F+ C TC + +H CL L+M+ P CP H C C L P K + L+ C+ C FH C+P + + IIC RHLV
Sbjct: 30 SKSYKVGQIICGKVGKYPWWPCMVNTIPTSNEPRVLVSYFGKKNDYSYLFDDCTMYAQTKSDFENIFKLHNHDKKTLA--RLAHY--KKQLDL---AWKEVEIASLLDENSRFELYKIKCEIKESINPP---KKRIRPPKPKKEKAASKPQEIIKREPIKYAF------------DELTLPFVSVKLTNKNCRYCLETKNIVQCNKCLFNNFHVKCLEFLQNSIETKINDLDRCLECSLGIIRCYACYKIVDISNEQGFMRCIIKTCTKWFHTNCLETGPMLEMTKFPKPGQLVCPCHICHKCEL---VNPSPKYRCT--KLIVCIMCPATFHTGDWCIPAGSVELNTGEIICPRHLV 360
BLAST of Histone-lysine N-methyltransferase, H3 lysine-36 and H4 lysine-20 specific vs. Planmine SMEST
Match: SMESG000081033.1 (SMESG000081033.1) HSP 1 Score: 68.5514 bits (166), Expect = 2.756e-11 Identity = 94/426 (22.07%), Postives = 162/426 (38.03%), Query Frame = 1
Query: 610 NNRNTKCGSYCSWKYHKDCVKD---------ENDLVCSCNKSVWLCSICCEVINVSQLFVCNNHTCMRPYHRLCLSAHLDMSPDMKQ-----CPLHSCINCALD--YLAEPESKRVQSHLDLVSCVKCKLAFHNIIDCLPTTFIRITRHLIICHRH----LVPSDLLQSNVAQFCFYCSRS-ISVHNPPVSCKYCLVTYHKCLPCLSGATELLDEHTFICNACK-FPYVHRGQCLALALPRETLTNDSVHSWKLGHLNLVT-ESTTGNKSVIVTEQTGKKWPTDIHRTIAINLQSLDHLV--SFGVLRF-QDIQYALRDLTKLVERVATSYNLCQNFYRNTFVLRFAG--LFPLVE---------NLYYGNASTFMDPNQSRPLAKPMKCDCLEACTTMKCPNVAANAECTDENCGAQNRCRNRRL 1776
NN +C C +H C+K+ N C ++ C +C +V + L C N C R YH+ CL + ++ CP H CI+C + A+ K+ LV C++C L+FH C+ ++ +IC +H LV + + +CF C ++ + +H C YC +YH + C+S +E E ++C C+ F G+ L + + + + + +N++ G V+ +W R+I N + S G R +D LR K + +V + L R+ L+P V A+ + P + P + CDC++ C C N EC C +C+N++
Sbjct: 155 NNAVLQCTGICKRYFHLHCLKNLKENQPTSKPNFQCLDCFSGIYHCILCQKVDKIDDLLACENSDCGRLYHKSCLEMSNFIGIEIHDNKILSCPSHYCISCVREDATFAQNPCKK------LVECLRCPLSFHCNDLCMAAGAYELSLSHVICPQHFENKLVKLNAHKPFHPAWCFKCFKTGVKLH-----CNYCPASYH--IECVSDYSE---ESRYVCYNCRNFRQPRYGEVLFVKVHQYRWWPCEIIHPRNAPMNILKLNRPDGTYPVLFLGSNEYQWVAKT-RSIDFNTAQFSSIFKESGGTTRMDRDFSSGLRVAGK-IHQVYVNILLMHVPLRSISASSMTAEELYPYVNVKEINQKTVKFKLIKANIIVPPAKLPPKVQASICDCVDNCPKQDCKNYLNKIECQITQCP---KCKNQQF 559 The following BLAST results are available for this feature:
BLAST of Histone-lysine N-methyltransferase, H3 lysine-36 and H4 lysine-20 specific vs. Ensembl Human
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Human e!99) Total hits: 5
BLAST of Histone-lysine N-methyltransferase, H3 lysine-36 and H4 lysine-20 specific vs. Ensembl Celegans
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99) Total hits: 4
BLAST of Histone-lysine N-methyltransferase, H3 lysine-36 and H4 lysine-20 specific vs. Ensembl Fly
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99) Total hits: 5
BLAST of Histone-lysine N-methyltransferase, H3 lysine-36 and H4 lysine-20 specific vs. Ensembl Zebrafish
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99) Total hits: 5
BLAST of Histone-lysine N-methyltransferase, H3 lysine-36 and H4 lysine-20 specific vs. Ensembl Xenopus
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99) Total hits: 5
BLAST of Histone-lysine N-methyltransferase, H3 lysine-36 and H4 lysine-20 specific vs. Ensembl Mouse
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99) Total hits: 5
BLAST of Histone-lysine N-methyltransferase, H3 lysine-36 and H4 lysine-20 specific vs. UniProt/SwissProt
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt) Total hits: 5
BLAST of Histone-lysine N-methyltransferase, H3 lysine-36 and H4 lysine-20 specific vs. TrEMBL
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL) Total hits: 5
BLAST of Histone-lysine N-methyltransferase, H3 lysine-36 and H4 lysine-20 specific vs. Ensembl Cavefish
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99) Total hits: 5
BLAST of Histone-lysine N-methyltransferase, H3 lysine-36 and H4 lysine-20 specific vs. Ensembl Sea Lamprey
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99) Total hits: 3
BLAST of Histone-lysine N-methyltransferase, H3 lysine-36 and H4 lysine-20 specific vs. Ensembl Yeast
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46) Total hits: 1
BLAST of Histone-lysine N-methyltransferase, H3 lysine-36 and H4 lysine-20 specific vs. Ensembl Nematostella
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46) Total hits: 2
BLAST of Histone-lysine N-methyltransferase, H3 lysine-36 and H4 lysine-20 specific vs. Ensembl Medaka
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99) Total hits: 5
BLAST of Histone-lysine N-methyltransferase, H3 lysine-36 and H4 lysine-20 specific vs. Planmine SMEST
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST) Total hits: 5
Analyses
This transcript is derived from or has results from the following analyses Sequences
The following sequences are available for this feature:
transcript sequence >SMED30011787 ID=SMED30011787|Name=Histone-lysine N-methyltransferase, H3 lysine-36 and H4 lysine-20 specific|organism=Schmidtea mediterranea sexual|type=transcript|length=3768bpback to top protein sequence of SMED30011787-orf-1 >SMED30011787-orf-1 ID=SMED30011787-orf-1|Name=SMED30011787-orf-1|organism=Schmidtea mediterranea sexual|type=polypeptide|length=820bp MISHQFSEGECIIGKLGTNPWWPGMIKECNNKNQAFVKFFEINIESWIDTback to top protein sequence of SMED30011787-orf-2 >SMED30011787-orf-2 ID=SMED30011787-orf-2|Name=SMED30011787-orf-2|organism=Schmidtea mediterranea sexual|type=polypeptide|length=138bp MTPCATGWSRRRASRISSARCALQCAPDVMSPLPFTSYPLEVLMHFGLSLback to top Annotated Terms
The following terms have been associated with this transcript:
InterPro
Analysis Name: Schmidtea mediteranean smed_20140614 Interproscan
Date Performed: 2020-05-01
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