Furin-1

Overview


Name	Furin-1
Smed ID	SMED30011738
Length (bp)	2237

Neoblast Clusters

▻ Sub-lethal Irradiated Surviving X1 and X2 Cell Population

Overview

Single cell RNA-seq of pluripotent neoblasts and its early progenies

We isolated X1 neoblasts cells enriched in high piwi-1 expression (Neoblast Population), and profiled ∼7,614 individual cells via scRNA-seq. Unsupervised analyses uncovered 12 distinct classes from 7,088 high-quality cells. We designated these classes Nb1 to Nb12 and ordered them based on high (Nb1) to low (Nb12) piwi-1 expression levels. We further defined groups of genes that best classified the cells parsed into 12 distinct cell clusters to generate a scaled expression heat map of discriminative gene sets for each cluster. Expression of each cluster’s gene signatures was validated using multiplex fluorescence in situ hybridization (FISH) co-stained with piwi-1 and largely confirmed the cell clusters revealed by scRNA-seq.

We also tested sub-lethal irradiation exposure. To profile rare pluripotent stem cells (PSCs) and avoid interference from immediate progenitor cells, we determined a time point after sub-lethal irradiation (7 DPI) with minimal piwi-1+ cells, followed by isolation and single-cell RNA-seq of 1,200 individual cells derived from X1 (Piwi-1 high) and X2 (Piwi-1 low) cell populations (Sub-lethal Irradiated Surviving X1 and X2 Cell Population)

Explore this single cell expression dataset with our NB Cluster Shiny App

Neoblast Population

t-SNE plot shows two-dimensional representation of global gene expression relationships among all neoblasts (n = 7,088 after filter). Cluster identity was assigned based on the top 10 marker genes of each cluster (Table S2), followed by inspection of RNA in situ hybridization patterns. Neoblast groups, Nb.

Expression of Furin-1 (SMED30011738) t-SNE clustered cells

Violin plots show distribution of expression levels for Furin-1 (SMED30011738) in cells (dots) of each of the 12 neoblast clusters.

Sub-lethal Irradiated Surviving X1 and X2 Cell Population

t-SNE plot of surviving X1 and X2 cells (n = 1,039 after QC filter) after sub-lethal irradiation. Colors indicate unbiased cell classification via graph-based clustering. SL, sub-lethal irradiated cell groups.

Expression of Furin-1 (SMED30011738) in the t-SNE clustered sub-lethally irradiated X1 and X2 cells.

Violin plots show distribution of expression levels for Furin-1 (SMED30011738) in cells (dots) of each of the 10 clusters of sub-leathally irradiated X1 and X2 cells.

Embryonic Expression

Davies et. al., 2017

Hover the mouse over a column in the graph to view average RPKM values per sample.
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Embryonic Stages: Y: yolk. S2-S8: Stages 2-8. C4: asexual adult. SX: virgin, sexually mature adult.
For further information about sample preparation and analysis for the single animal RNA-Seq experiment, please refer to the Materials and Methods

Anatomical Expression

PAGE et. al., 2020

SMED30011738

has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGE

PAGE Curations: 4

Expressed In	Reference Transcript	Gene Models	Published Transcript	Transcriptome	Publication
muscle cell	SMED30011738	SMESG000049794.1	dd_Smed_v4_10832_0_1	dd_Smed_v4	PMID:29674431 Fincher et al., 2018
Smed sexual biotype	SMED30011738	SMESG000049794.1	Contig48594	newmark_ests	PMID:29674431 Fincher et al., 2018
Smed sexual biotype	SMED30011738	SMESG000049794.1	Contig48594	uc_Smed_v2	PMID:29674431 Fincher et al., 2018
enteric muscle cell	SMED30011738	SMESG000049794.1	dd_Smed_v4_10832_0_1	dd_Smed_v4	PMID:30471994 Scimone et al., 2018

Note: Hover over icons to view figure legend

Homology

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BLAST of Furin-1 vs. Ensembl Human
Match: PCSK6 (proprotein convertase subtilisin/kexin type 6 [Source:HGNC Symbol;Acc:HGNC:8569])

HSP 1 Score: 590.112 bits (1520), Expect = 0.000e+0
Identity = 307/594 (51.68%), Postives = 398/594 (67.00%), Query Frame = 1

Query:  160 SQSESRGHYTDTWAVQINGTVDDARILAATYGFVFLNEI--MPSIYSFKHRRVSKRSIYPSNYYQSNLSDDPRVIWLEQQFAKVRVKRHI--------VNDPKWYKMWYLNKMNK----ENSMNIISAWKKGYRGQNVVVSILDDGIEKDHPDLKENYDPNASYDIISNDNNPEPRYISSNNTKIKDNHHGTRCAGQVAATANNRICGVGVAYKANIGGIRMLDGEVSDSVESHSLRLFYQHIDIYSASWGPEDDGKTVDGPGELAKIAFEDGILKGRNGLGSIFVWASGNGGKNHDNCNCDGYTNSIFTLGVNAVSEIGDAPWYAEKCSSTLAVTYSSGSMDERAIITTDVNHECTEQHSGTSASAPFAAGICALALSANRFLTWRDMQHLVVITARKANLRAVDWSTNAAGKEYSHSFGFGLMDAGAMVDLALNWTTVPEQHICHYVAPMQGGPISLKPYANEVLSITTDACSDNSKKRVRYLEHVQAKISLRSTKRGEVELWLISPSRSTSKLLTKRRNDVASAGFHHWPFMSVHFWGEEAPGTWKLTIYSYDAEV-------TLINWSLILYGTDTLPSHRQNSTHTKSQ 1878
            S    R  YT+ WAVQ+ G   +A  +AA +G++ L +I  +   Y F H +  KRS   S    + L  DP+V WL+QQ  K RVKR +         NDP W  MWYL+  +K     + MN+ +AWK+GY G+NVVV+ILDDGIE++HPDL  NYD  ASYD+  ND +P PRY +SN     +N HGTRCAG+VAA+ANN  C VG+AY A IGGIRMLDG+V+D VE+ SL +   +IDIYSASWGP+DDGKTVDGPG LAK AFE GI KGR GLGSIFVWASGNGG+  D C+CDGYTNSI+T+ V++ +E G  PWY E+C+STLA TYSSG+  ER I+TTD+   CT+ H+GTS SAP  AGI ALAL AN  LTWRD+QHL+V T+R A+L+A DW  N AG + SH +GFGL+DA A+V  A  WT VP QH+C  VA     P S+        +  T AC+++S +RV YLEHV  + S+   +RG+++++L+SPS + S+LL KR  D+++ GF +W FM+VH WGE+A G W L I    ++V        L  WSLILYGT   P H  ++  ++S+
Sbjct:   62 SAPPPRPVYTNHWAVQVLGGPAEADRVAAAHGYLNLGQIGNLEDYYHFYHSKTFKRSTLSSRGPHTFLRMDPQVKWLQQQEVKRRVKRQVRSDPQALYFNDPIWSNMWYLHCGDKNSRCRSEMNVQAAWKRGYTGKNVVVTILDDGIERNHPDLAPNYDSYASYDVNGNDYDPSPRYDASN-----ENKHGTRCAGEVAASANNSYCIVGIAYNAKIGGIRMLDGDVTDVVEAKSLGIRPNYIDIYSASWGPDDDGKTVDGPGRLAKQAFEYGIKKGRQGLGSIFVWASGNGGREGDYCSCDGYTNSIYTISVSSATENGYKPWYLEECASTLATTYSSGAFYERKIVTTDLRQRCTDGHTGTSVSAPMVAGIIALALEANSQLTWRDVQHLLVKTSRPAHLKASDWKVNGAGHKVSHFYGFGLVDAEALVVEAKKWTAVPSQHMC--VAASDKRPRSIPLVQVLRTTALTSACAEHSDQRVVYLEHVVVRTSISHPRRGDLQIYLVSPSGTKSQLLAKRLLDLSNEGFTNWEFMTVHCWGEKAEGQWTLEIQDLPSQVRNPEKQGKLKEWSLILYGTAEHPYHTFSAHQSRSR 648

[Close]

BLAST of Furin-1 vs. Ensembl Human
Match: PCSK6 (proprotein convertase subtilisin/kexin type 6 [Source:HGNC Symbol;Acc:HGNC:8569])

HSP 1 Score: 590.112 bits (1520), Expect = 0.000e+0
Identity = 306/589 (51.95%), Postives = 397/589 (67.40%), Query Frame = 1

Query:  175 RGHYTDTWAVQINGTVDDARILAATYGFVFLNEI--MPSIYSFKHRRVSKRSIYPSNYYQSNLSDDPRVIWLEQQFAKVRVKRHI--------VNDPKWYKMWYLNKMNK----ENSMNIISAWKKGYRGQNVVVSILDDGIEKDHPDLKENYDPNASYDIISNDNNPEPRYISSNNTKIKDNHHGTRCAGQVAATANNRICGVGVAYKANIGGIRMLDGEVSDSVESHSLRLFYQHIDIYSASWGPEDDGKTVDGPGELAKIAFEDGILKGRNGLGSIFVWASGNGGKNHDNCNCDGYTNSIFTLGVNAVSEIGDAPWYAEKCSSTLAVTYSSGSMDERAIITTDVNHECTEQHSGTSASAPFAAGICALALSANRFLTWRDMQHLVVITARKANLRAVDWSTNAAGKEYSHSFGFGLMDAGAMVDLALNWTTVPEQHICHYVAPMQGGPISLKPYANEVLSITTDACSDNSKKRVRYLEHVQAKISLRSTKRGEVELWLISPSRSTSKLLTKRRNDVASAGFHHWPFMSVHFWGEEAPGTWKLTIYSYDAEV-------TLINWSLILYGTDTLPSHRQNSTHTKSQ 1878
            R  YT+ WAVQ+ G   +A  +AA +G++ L +I  +   Y F H +  KRS   S    + L  DP+V WL+QQ  K RVKR +         NDP W  MWYL+  +K     + MN+ +AWK+GY G+NVVV+ILDDGIE++HPDL  NYD  ASYD+  ND +P PRY +SN     +N HGTRCAG+VAA+ANN  C VG+AY A IGGIRMLDG+V+D VE+ SL +   +IDIYSASWGP+DDGKTVDGPG LAK AFE GI KGR GLGSIFVWASGNGG+  D C+CDGYTNSI+T+ V++ +E G  PWY E+C+STLA TYSSG+  ER I+TTD+   CT+ H+GTS SAP  AGI ALAL AN  LTWRD+QHL+V T+R A+L+A DW  N AG + SH +GFGL+DA A+V  A  WT VP QH+C  VA     P S+        +  T AC+++S +RV YLEHV  + S+   +RG+++++L+SPS + S+LL KR  D+++ GF +W FM+VH WGE+A G W L I    ++V        L  WSLILYGT   P H  ++  ++S+
Sbjct:   67 RPVYTNHWAVQVLGGPAEADRVAAAHGYLNLGQIGNLEDYYHFYHSKTFKRSTLSSRGPHTFLRMDPQVKWLQQQEVKRRVKRQVRSDPQALYFNDPIWSNMWYLHCGDKNSRCRSEMNVQAAWKRGYTGKNVVVTILDDGIERNHPDLAPNYDSYASYDVNGNDYDPSPRYDASN-----ENKHGTRCAGEVAASANNSYCIVGIAYNAKIGGIRMLDGDVTDVVEAKSLGIRPNYIDIYSASWGPDDDGKTVDGPGRLAKQAFEYGIKKGRQGLGSIFVWASGNGGREGDYCSCDGYTNSIYTISVSSATENGYKPWYLEECASTLATTYSSGAFYERKIVTTDLRQRCTDGHTGTSVSAPMVAGIIALALEANSQLTWRDVQHLLVKTSRPAHLKASDWKVNGAGHKVSHFYGFGLVDAEALVVEAKKWTAVPSQHMC--VAASDKRPRSIPLVQVLRTTALTSACAEHSDQRVVYLEHVVVRTSISHPRRGDLQIYLVSPSGTKSQLLAKRLLDLSNEGFTNWEFMTVHCWGEKAEGQWTLEIQDLPSQVRNPEKQGKLKEWSLILYGTAEHPYHTFSAHQSRSR 648

[Close]

BLAST of Furin-1 vs. Ensembl Human
Match: PCSK6 (proprotein convertase subtilisin/kexin type 6 [Source:HGNC Symbol;Acc:HGNC:8569])

HSP 1 Score: 589.341 bits (1518), Expect = 0.000e+0
Identity = 307/594 (51.68%), Postives = 398/594 (67.00%), Query Frame = 1

Query:  160 SQSESRGHYTDTWAVQINGTVDDARILAATYGFVFLNEI--MPSIYSFKHRRVSKRSIYPSNYYQSNLSDDPRVIWLEQQFAKVRVKRHI--------VNDPKWYKMWYLNKMNK----ENSMNIISAWKKGYRGQNVVVSILDDGIEKDHPDLKENYDPNASYDIISNDNNPEPRYISSNNTKIKDNHHGTRCAGQVAATANNRICGVGVAYKANIGGIRMLDGEVSDSVESHSLRLFYQHIDIYSASWGPEDDGKTVDGPGELAKIAFEDGILKGRNGLGSIFVWASGNGGKNHDNCNCDGYTNSIFTLGVNAVSEIGDAPWYAEKCSSTLAVTYSSGSMDERAIITTDVNHECTEQHSGTSASAPFAAGICALALSANRFLTWRDMQHLVVITARKANLRAVDWSTNAAGKEYSHSFGFGLMDAGAMVDLALNWTTVPEQHICHYVAPMQGGPISLKPYANEVLSITTDACSDNSKKRVRYLEHVQAKISLRSTKRGEVELWLISPSRSTSKLLTKRRNDVASAGFHHWPFMSVHFWGEEAPGTWKLTIYSYDAEV-------TLINWSLILYGTDTLPSHRQNSTHTKSQ 1878
            S    R  YT+ WAVQ+ G   +A  +AA +G++ L +I  +   Y F H +  KRS   S    + L  DP+V WL+QQ  K RVKR +         NDP W  MWYL+  +K     + MN+ +AWK+GY G+NVVV+ILDDGIE++HPDL  NYD  ASYD+  ND +P PRY +SN     +N HGTRCAG+VAA+ANN  C VG+AY A IGGIRMLDG+V+D VE+ SL +   +IDIYSASWGP+DDGKTVDGPG LAK AFE GI KGR GLGSIFVWASGNGG+  D C+CDGYTNSI+T+ V++ +E G  PWY E+C+STLA TYSSG+  ER I+TTD+   CT+ H+GTS SAP  AGI ALAL AN  LTWRD+QHL+V T+R A+L+A DW  N AG + SH +GFGL+DA A+V  A  WT VP QH+C  VA     P S+        +  T AC+++S +RV YLEHV  + S+   +RG+++++L+SPS + S+LL KR  D+++ GF +W FM+VH WGE+A G W L I    ++V        L  WSLILYGT   P H  ++  ++S+
Sbjct:   62 SAPPPRPVYTNHWAVQVLGGPAEADRVAAAHGYLNLGQIGNLEDYYHFYHSKTFKRSTLSSRGPHTFLRMDPQVKWLQQQEVKRRVKRQVRSDPQALYFNDPIWSNMWYLHCGDKNSRCRSEMNVQAAWKRGYTGKNVVVTILDDGIERNHPDLAPNYDSYASYDVNGNDYDPSPRYDASN-----ENKHGTRCAGEVAASANNSYCIVGIAYNAKIGGIRMLDGDVTDVVEAKSLGIRPNYIDIYSASWGPDDDGKTVDGPGRLAKQAFEYGIKKGRQGLGSIFVWASGNGGREGDYCSCDGYTNSIYTISVSSATENGYKPWYLEECASTLATTYSSGAFYERKIVTTDLRQRCTDGHTGTSVSAPMVAGIIALALEANSQLTWRDVQHLLVKTSRPAHLKASDWKVNGAGHKVSHFYGFGLVDAEALVVEAKKWTAVPSQHMC--VAASDKRPRSIPLVQVLRTTALTSACAEHSDQRVVYLEHVVVRTSISHPRRGDLQIYLVSPSGTKSQLLAKRLLDLSNEGFTNWEFMTVHCWGEKAEGQWTLEIQDLPSQVRNPEKQGKLKEWSLILYGTAEHPYHTFSAHQSRSR 648

[Close]

Query:  160 SQSESRGHYTDTWAVQINGTVDDARILAATYGFVFLNEI--MPSIYSFKHRRVSKRSIYPSNYYQSNLSDDPRVIWLEQQFAKVRVKRHI--------VNDPKWYKMWYLNKMNK----ENSMNIISAWKKGYRGQNVVVSILDDGIEKDHPDLKENYDPNASYDIISNDNNPEPRYISSNNTKIKDNHHGTRCAGQVAATANNRICGVGVAYKANIGGIRMLDGEVSDSVESHSLRLFYQHIDIYSASWGPEDDGKTVDGPGELAKIAFEDGILKGRNGLGSIFVWASGNGGKNHDNCNCDGYTNSIFTLGVNAVSEIGDAPWYAEKCSSTLAVTYSSGSMDERAIITTDVNHECTEQHSGTSASAPFAAGICALALSANRFLTWRDMQHLVVITARKANLRAVDWSTNAAGKEYSHSFGFGLMDAGAMVDLALNWTTVPEQHICHYVAPMQGGPISLKPYANEVLSITTDACSDNSKKRVRYLEHVQAKISLRSTKRGEVELWLISPSRSTSKLLTKRRNDVASAGFHHWPFMSVHFWGEEAPGTWKLTIYSYDAEV-------TLINWSLILYGTDTLPSHRQNSTHTKSQ 1878
            S    R  YT+ WAVQ+ G   +A  +AA +G++ L +I  +   Y F H +  KRS   S    + L  DP+V WL+QQ  K RVKR +         NDP W  MWYL+  +K     + MN+ +AWK+GY G+NVVV+ILDDGIE++HPDL  NYD  ASYD+  ND +P PRY +SN     +N HGTRCAG+VAA+ANN  C VG+AY A IGGIRMLDG+V+D VE+ SL +   +IDIYSASWGP+DDGKTVDGPG LAK AFE GI KGR GLGSIFVWASGNGG+  D C+CDGYTNSI+T+ V++ +E G  PWY E+C+STLA TYSSG+  ER I+TTD+   CT+ H+GTS SAP  AGI ALAL AN  LTWRD+QHL+V T+R A+L+A DW  N AG + SH +GFGL+DA A+V  A  WT VP QH+C  VA     P S+        +  T AC+++S +RV YLEHV  + S+   +RG+++++L+SPS + S+LL KR  D+++ GF +W FM+VH WGE+A G W L I    ++V        L  WSLILYGT   P H  ++  ++S+
Sbjct:   62 SAPPPRPVYTNHWAVQVLGGPAEADRVAAAHGYLNLGQIGNLEDYYHFYHSKTFKRSTLSSRGPHTFLRMDPQVKWLQQQEVKRRVKRQVRSDPQALYFNDPIWSNMWYLHCGDKNSRCRSEMNVQAAWKRGYTGKNVVVTILDDGIERNHPDLAPNYDSYASYDVNGNDYDPSPRYDASN-----ENKHGTRCAGEVAASANNSYCIVGIAYNAKIGGIRMLDGDVTDVVEAKSLGIRPNYIDIYSASWGPDDDGKTVDGPGRLAKQAFEYGIKKGRQGLGSIFVWASGNGGREGDYCSCDGYTNSIYTISVSSATENGYKPWYLEECASTLATTYSSGAFYERKIVTTDLRQRCTDGHTGTSVSAPMVAGIIALALEANSQLTWRDVQHLLVKTSRPAHLKASDWKVNGAGHKVSHFYGFGLVDAEALVVEAKKWTAVPSQHMC--VAASDKRPRSIPLVQVLRTTALTSACAEHSDQRVVYLEHVVVRTSISHPRRGDLQIYLVSPSGTKSQLLAKRLLDLSNEGFTNWEFMTVHCWGEKAEGQWTLEIQDLPSQVRNPEKQGKLKEWSLILYGTAEHPYHTFSAHQSRSR 648

[Close]

BLAST of Furin-1 vs. Ensembl Human
Match: FURIN (furin, paired basic amino acid cleaving enzyme [Source:HGNC Symbol;Acc:HGNC:8568])

HSP 1 Score: 582.408 bits (1500), Expect = 0.000e+0
Identity = 303/597 (50.75%), Postives = 399/597 (66.83%), Query Frame = 1

Query:  121 VILFSSLFCFGAKSQSESRGHYTDTWAVQINGTVDDARILAATYGFVFLNEIMPSIYSFKHRRVSKRSIYPSNYYQSNLSDDPRVIWLEQQFAKVRVKRHIVN---DPKWYKMWYLNKMNKENSMNIISAWKKGYRGQNVVVSILDDGIEKDHPDLKENYDPNASYDIISNDNNPEPRYISSNNTKIKDNHHGTRCAGQVAATANNRICGVGVAYKANIGGIRMLDGEVSDSVESHSLRLFYQHIDIYSASWGPEDDGKTVDGPGELAKIAFEDGILKGRNGLGSIFVWASGNGGKNHDNCNCDGYTNSIFTLGVNAVSEIGDAPWYAEKCSSTLAVTYSSGSMDERAIITTDVNHECTEQHSGTSASAPFAAGICALALSANRFLTWRDMQHLVVITARKANLRAVDWSTNAAGKEYSHSFGFGLMDAGAMVDLALNWTTVPEQHICHYVAPMQGGPISLKPYANEVLSITTDACSDNSKKRVRYLEHVQAKISLRSTKRGEVELWLISPSRSTSKLLTKRRNDVASAGFHHWPFMSVHFWGEEAPGTWKLTIYSYDAE---VTLINWSLILYGT--DTLPSHRQNS---THTKSQ 1878
            V    +L    A +Q +    +T+TWAV+I G    A  +A  +GF+ L +I    Y F HR V+KRS+ P     S L  +P+V WLEQQ AK R KR +     DPK+ + WYL+ + + + +N+ +AW +GY G  +VVSILDDGIEK+HPDL  NYDP AS+D+   D +P+PRY     T++ DN HGTRCAG+VAA ANN +CGVGVAY A IGG+RMLDGEV+D+VE+ SL L   HI IYSASWGPEDDGKTVDGP  LA+ AF  G+ +GR GLGSIFVWASGNGG+ HD+CNCDGYTNSI+TL +++ ++ G+ PWY+E CSSTLA TYSSG+ +E+ I+TTD+  +CTE H+GTSASAP AAGI AL L AN+ LTWRDMQHLVV T++ A+L A DW+TN  G++ SHS+G+GL+DAGAMV LA NWTTV  Q  C  +  +   P  +        ++T  AC        R LEH QA+++L   +RG++ + L+SP  + S LL  R +D ++ GF+ W FM+ H W E+  G W L I +        TL  ++L+LYGT  + LP   ++S   T T SQ
Sbjct:   11 VAATGTLVLLAADAQGQKV--FTNTWAVRIPGGPAVANSVARKHGFLNLGQIFGDYYHFWHRGVTKRSLSPHRPRHSRLQREPQVQWLEQQVAKRRTKRDVYQEPTDPKFPQQWYLSGVTQRD-LNVKAAWAQGYTGHGIVVSILDDGIEKNHPDLAGNYDPGASFDVNDQDPDPQPRY-----TQMNDNRHGTRCAGEVAAVANNGVCGVGVAYNARIGGVRMLDGEVTDAVEARSLGLNPNHIHIYSASWGPEDDGKTVDGPARLAEEAFFRGVSQGRGGLGSIFVWASGNGGREHDSCNCDGYTNSIYTLSISSATQFGNVPWYSEACSSTLATTYSSGNQNEKQIVTTDLRQKCTESHTGTSASAPLAAGIIALTLEANKNLTWRDMQHLVVQTSKPAHLNANDWATNGVGRKVSHSYGYGLLDAGAMVALAQNWTTVAPQRKC--IIDILTEPKDIGKRLEVRKTVT--ACLGEPNHITR-LEHAQARLTLSYNRRGDLAIHLVSPMGTRSTLLAARPHDYSADGFNDWAFMTTHSWDEDPSGEWVLEIENTSEANNYGTLTKFTLVLYGTAPEGLPVPPESSGCKTLTSSQ 594

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BLAST of Furin-1 vs. Ensembl Celegans
Match: kpc-1 (Furin-like protease kpc-1 [Source:UniProtKB/Swiss-Prot;Acc:O17798])

HSP 1 Score: 565.459 bits (1456), Expect = 0.000e+0
Identity = 302/603 (50.08%), Postives = 386/603 (64.01%), Query Frame = 1

Query:  166 SESRGHYTDTWAVQI-NGTVDDARILAATYGFVFLNEIMPS--IYSFKHRRVSKRSIYPSNYYQSN-LSDDPRVIWLEQQFAKVRVKRHIV--------------------------------NDPKWYKMWYLNKMNKENSM------NIISAWKKGYRGQNVVVSILDDGIEKDHPDLKENYDPNASYDIISNDNNPEPRYISSNNTKIKDNHHGTRCAGQVAATANNRICGVGVAYKANIGGIRMLDGEVSDSVESHSLRLFYQHIDIYSASWGPEDDGKTVDGPGELAKIAFEDGILKGRNGLGSIFVWASGNGGKNHDNCNCDGYTNSIFTLGVNAVSEIGDAPWYAEKCSSTLAVTYSSGSMDERAIITTDVNHECTEQHSGTSASAPFAAGICALALSANRFLTWRDMQHLVVITARKANLRAVDWSTNAAGKEYSHSFGFGLMDAGAMVDLALNWTTVPEQHICHYVAPMQGGPISLKPYANEV-LSITTDACSDNS-KKRVRYLEHVQAKISLRSTKRGEVELWLISPSRSTSKLLTKRRNDVASAGFHHWPFMSVHFWGEEAPGTWKLTIYS---YDAEVTLINWSLILYGTD 1833
            S  R  YT+ WAV+I  G V++A  LA  YG+  L  I+P    Y F+  R   RS   +    +N L  +  V+W+EQQ AK RVKR                                   NDP W  MWYLN+    +        N+  AW  GY G+ VVV+ILDDG+E+ HPD+  NYD  ASYD+   DN+P PRY  S+     +N HGTRCAG+VAA  NN +C VG+AY ANIGGIRMLDG+V+D+VE+ S+     +IDIYSASWGP+DDG+TVDGP +L + AFE GI  GR G GSIFVWASGNGGK+ D+CNCDGYTNSI+TL +++ +E G+ PWY+E CSSTLA TYSSG+  E+ I+TTD++H CT  H+GTSASAP AAGI ALAL AN  LTWRD+QH+V+ TA+  NLRA DW+TN  G+  SHSFG+GLMDAGAMV LA  W  V EQH C    P +   I   P  N + L + +D C   + + +V Y+EHVQA ++L++ KRG+++++L SPS + S LLTKR  D + +GF  W FM+ H WGE+A G W L I +    DAE  L+ W L+LYGTD
Sbjct:   52 SPMRRTYTNEWAVRIAGGKVEEANRLANKYGYTNLGPIIPGDEYYLFRDDRKKSRSSRKTRSLSANQLQHEEDVMWMEQQVAKRRVKRGYRRIRRHTDDNDIFEEDDDGTQISKSRNRKHPDPNDPLWTDMWYLNRGEHHSDSTTRMDHNVKEAWDLGYTGKGVVVTILDDGLERTHPDISPNYDERASYDVNDRDNDPMPRYEFSD-----ENRHGTRCAGEVAAIFNNSLCIVGIAYNANIGGIRMLDGDVTDAVEAASVGHNADYIDIYSASWGPDDDGRTVDGPAKLTRSAFEKGITMGRKGKGSIFVWASGNGGKDADSCNCDGYTNSIYTLSISSATENGNIPWYSEACSSTLATTYSSGATGEKMILTTDLHHACTNMHTGTSASAPLAAGIVALALEANPNLTWRDLQHIVIRTAKPINLRAGDWTTNGVGRNVSHSFGYGLMDAGAMVKLAKIWKKVDEQHRCRQFYPSRYKNI---PNGNRLQLQLYSDGCYGGADENKVSYVEHVQAIVTLKAPKRGDLQIYLTSPSGTKSTLLTKRARDTSRSGFTDWAFMTTHNWGEQAAGLWILEIDNDGWDDAE--LVKWELVLYGTD 644

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Query:  166 SESRGHYTDTWAVQI-NGTVDDARILAATYGFVFLNEIMPS--IYSFKHRRVSKRSIYPSNYYQSN-LSDDPRVIWLEQQFAKVRVKRHIV--------------------------------NDPKWYKMWYLNKMNKENSM------NIISAWKKGYRGQNVVVSILDDGIEKDHPDLKENYDPNASYDIISNDNNPEPRYISSNNTKIKDNHHGTRCAGQVAATANNRICGVGVAYKANIGGIRMLDGEVSDSVESHSLRLFYQHIDIYSASWGPEDDGKTVDGPGELAKIAFEDGILKGRNGLGSIFVWASGNGGKNHDNCNCDGYTNSIFTLGVNAVSEIGDAPWYAEKCSSTLAVTYSSGSMDERAIITTDVNHECTEQHSGTSASAPFAAGICALALSANRFLTWRDMQHLVVITARKANLRAVDWSTNAAGKEYSHSFGFGLMDAGAMVDLALNWTTVPEQHICHYVAPMQGGPISLKPYANEV-LSITTDACSDNS-KKRVRYLEHVQAKISLRSTKRGEVELWLISPSRSTSKLLTKRRNDVASAGFHHWPFMSVHFWGEEAPGTWKLTIYS---YDAEVTLINWSLILYGTD 1833
            S  R  YT+ WAV+I  G V++A  LA  YG+  L  I+P    Y F+  R   RS   +    +N L  +  V+W+EQQ AK RVKR                                   NDP W  MWYLN+    +        N+  AW  GY G+ VVV+ILDDG+E+ HPD+  NYD  ASYD+   DN+P PRY  S+     +N HGTRCAG+VAA  NN +C VG+AY ANIGGIRMLDG+V+D+VE+ S+     +IDIYSASWGP+DDG+TVDGP +L + AFE GI  GR G GSIFVWASGNGGK+ D+CNCDGYTNSI+TL +++ +E G+ PWY+E CSSTLA TYSSG+  E+ I+TTD++H CT  H+GTSASAP AAGI ALAL AN  LTWRD+QH+V+ TA+  NLRA DW+TN  G+  SHSFG+GLMDAGAMV LA  W  V EQH C    P +   I   P  N + L + +D C   + + +V Y+EHVQA ++L++ KRG+++++L SPS + S LLTKR  D + +GF  W FM+ H WGE+A G W L I +    DAE  L+ W L+LYGTD
Sbjct:   52 SPMRRTYTNEWAVRIAGGKVEEANRLANKYGYTNLGPIIPGDEYYLFRDDRKKSRSSRKTRSLSANQLQHEEDVMWMEQQVAKRRVKRGYRRIRRHTDDNDIFEEDDDGTQISKSRNRKHPDPNDPLWTDMWYLNRGEHHSDSTTRMDHNVKEAWDLGYTGKGVVVTILDDGLERTHPDISPNYDERASYDVNDRDNDPMPRYEFSD-----ENRHGTRCAGEVAAIFNNSLCIVGIAYNANIGGIRMLDGDVTDAVEAASVGHNADYIDIYSASWGPDDDGRTVDGPAKLTRSAFEKGITMGRKGKGSIFVWASGNGGKDADSCNCDGYTNSIYTLSISSATENGNIPWYSEACSSTLATTYSSGATGEKMILTTDLHHACTNMHTGTSASAPLAAGIVALALEANPNLTWRDLQHIVIRTAKPINLRAGDWTTNGVGRNVSHSFGYGLMDAGAMVKLAKIWKKVDEQHRCRQFYPSRYKNI---PNGNRLQLQLYSDGCYGGADENKVSYVEHVQAIVTLKAPKRGDLQIYLTSPSGTKSTLLTKRARDTSRSGFTDWAFMTTHNWGEQAAGLWILEIDNDGWDDAE--LVKWELVLYGTD 644

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BLAST of Furin-1 vs. Ensembl Celegans
Match: bli-4 (Endoprotease bli-4 [Source:UniProtKB/Swiss-Prot;Acc:P51559])

HSP 1 Score: 477.248 bits (1227), Expect = 1.947e-159
Identity = 269/584 (46.06%), Postives = 338/584 (57.88%), Query Frame = 1

Query:  229 ARILAATYGFVFLNEIMPSIYSFKHRRVSKRSIYPSNYYQSNLSDDPRVIWLEQQFAKVRVKRHIV-----------------------------------------NDPKWYKMWYLNKMNKEN-SMNIISAWKKGYRGQNVVVSILDDGIEKDHPDLKENYDPNASYDIISNDNNPEPRYISSNNTKIKDNHHGTRCAGQVAATANNRICGVGVAYKANIGGIRMLDGEVSDSVESHSLRLFYQHIDIYSASWGPEDDGKTVDGPGELAKIAFEDGILKGRNGLGSIFVWASGNGGKNHDNCNCDGYTNSIFTLGVNAVSEIGDAPWYAEKCSSTLAVTYSSGSMDERAIITTDVNHECTEQHSGTSASAPFAAGICALALSANRFLTWRDMQHLVVITARKANLRAVD----WSTNAAGKEYSHSFGFGLMDAGAMVDLALNWTTVPEQHICHYVAPMQGGPISLKPYANEVLSITTDACSDNSKKRVRYLEHVQAKISLRSTKRGEVELWLISPSRSTSKLLTKRRNDVASAGFHHWPFMSVHFWGEEAPGTWKLTIYSYD----AEVTLINWSLILYGT 1830
            AR +AA +      +     + F +   + R+          L   P V W+E+Q  K RVKR  +                                          DP +   WYL+        MN+  AW +GY G+NV VSILDDGI++DHPDL  NYDP AS DI  +D++P P+    NN    DN HGTRCAG+VAA A N  CGVGVA+KA IGG+RMLDG VSDSVE+ SL L   HIDIYSASWGPEDDGKT DGPG LA+ AF  GI  GR G G+IFVWASGNGG   D+C+ DGYT S++TL +++ +     PWY E+C S++A TYSS    + AI+T DV   CT++H+GTSASAP AAGI ALAL AN  LTWRDMQHLV+   R AN + ++    WS N  G+  S+ FG+GL+D GA+V++A  W TVPEQHIC Y   +   P          L+ T D     S   V YLEHVQ   ++R  KRG+++L L SPS + S LL  R  D  + GFH WPF+SV  WGE+  GTW L + S      A  T  +W+L+LYGT
Sbjct:   54 ARRIAADHDMHVKGDPFLDTHYFLYHSETTRTRRHKRAIVERLDSHPAVEWVEEQRPKKRVKRDYILLDNDVHHSNPFRRSVLNRDGTRRAQRQQPQSPREIPSLPFPDPLYKDQWYLHGGAVGGYDMNVRQAWLQGYAGRNVSVSILDDGIQRDHPDLAANYDPLASTDINDHDDDPTPQ----NN---GDNKHGTRCAGEVAALAGNNQCGVGVAFKAKIGGVRMLDGAVSDSVEAASLSLNQDHIDIYSASWGPEDDGKTFDGPGPLAREAFYRGIKNGRGGKGNIFVWASGNGGSRQDSCSADGYTTSVYTLSISSATYDNHRPWYLEECPSSIATTYSSADFRQPAIVTVDVPGGCTDKHTGTSASAPLAAGIIALALEANPELTWRDMQHLVL---RTANWKPLENNPGWSRNGVGRMVSNKFGYGLIDGGALVNMAKTWKTVPEQHICTYEYRL-ANPNPRPIVGRFQLNFTLDVNGCESGTPVLYLEHVQVHATVRYLKRGDLKLTLFSPSGTRSVLLPPRPQDFNANGFHKWPFLSVQQWGEDPRGTWLLMVESVTTNPAATGTFHDWTLLLYGT 626

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Query:  229 ARILAATYGFVFLNEIMPSIYSFKHRRVSKRSIYPSNYYQSNLSDDPRVIWLEQQFAKVRVKRHIV-----------------------------------------NDPKWYKMWYLNKMNKEN-SMNIISAWKKGYRGQNVVVSILDDGIEKDHPDLKENYDPNASYDIISNDNNPEPRYISSNNTKIKDNHHGTRCAGQVAATANNRICGVGVAYKANIGGIRMLDGEVSDSVESHSLRLFYQHIDIYSASWGPEDDGKTVDGPGELAKIAFEDGILKGRNGLGSIFVWASGNGGKNHDNCNCDGYTNSIFTLGVNAVSEIGDAPWYAEKCSSTLAVTYSSGSMDERAIITTDVNHECTEQHSGTSASAPFAAGICALALSANRFLTWRDMQHLVVITARKANLRAVD----WSTNAAGKEYSHSFGFGLMDAGAMVDLALNWTTVPEQHICHYVAPMQGGPISLKPYANEVLSITTDACSDNSKKRVRYLEHVQAKISLRSTKRGEVELWLISPSRSTSKLLTKRRNDVASAGFHHWPFMSVHFWGEEAPGTWKLTIYSYD----AEVTLINWSLILYGT 1830
            AR +AA +      +     + F +   + R+          L   P V W+E+Q  K RVKR  +                                          DP +   WYL+        MN+  AW +GY G+NV VSILDDGI++DHPDL  NYDP AS DI  +D++P P+    NN    DN HGTRCAG+VAA A N  CGVGVA+KA IGG+RMLDG VSDSVE+ SL L   HIDIYSASWGPEDDGKT DGPG LA+ AF  GI  GR G G+IFVWASGNGG   D+C+ DGYT S++TL +++ +     PWY E+C S++A TYSS    + AI+T DV   CT++H+GTSASAP AAGI ALAL AN  LTWRDMQHLV+   R AN + ++    WS N  G+  S+ FG+GL+D GA+V++A  W TVPEQHIC Y   +   P          L+ T D     S   V YLEHVQ   ++R  KRG+++L L SPS + S LL  R  D  + GFH WPF+SV  WGE+  GTW L + S      A  T  +W+L+LYGT
Sbjct:   54 ARRIAADHDMHVKGDPFLDTHYFLYHSETTRTRRHKRAIVERLDSHPAVEWVEEQRPKKRVKRDYILLDNDVHHSNPFRRSVLNRDGTRRAQRQQPQSPREIPSLPFPDPLYKDQWYLHGGAVGGYDMNVRQAWLQGYAGRNVSVSILDDGIQRDHPDLAANYDPLASTDINDHDDDPTPQ----NN---GDNKHGTRCAGEVAALAGNNQCGVGVAFKAKIGGVRMLDGAVSDSVEAASLSLNQDHIDIYSASWGPEDDGKTFDGPGPLAREAFYRGIKNGRGGKGNIFVWASGNGGSRQDSCSADGYTTSVYTLSISSATYDNHRPWYLEECPSSIATTYSSADFRQPAIVTVDVPGGCTDKHTGTSASAPLAAGIIALALEANPELTWRDMQHLVL---RTANWKPLENNPGWSRNGVGRMVSNKFGYGLIDGGALVNMAKTWKTVPEQHICTYEYRL-ANPNPRPIVGRFQLNFTLDVNGCESGTPVLYLEHVQVHATVRYLKRGDLKLTLFSPSGTRSVLLPPRPQDFNANGFHKWPFLSVQQWGEDPRGTWLLMVESVTTNPAATGTFHDWTLLLYGT 626

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BLAST of Furin-1 vs. Ensembl Celegans
Match: bli-4 (Endoprotease bli-4 [Source:UniProtKB/Swiss-Prot;Acc:P51559])

HSP 1 Score: 477.248 bits (1227), Expect = 2.734e-159
Identity = 269/584 (46.06%), Postives = 338/584 (57.88%), Query Frame = 1

Query:  229 ARILAATYGFVFLNEIMPSIYSFKHRRVSKRSIYPSNYYQSNLSDDPRVIWLEQQFAKVRVKRHIV-----------------------------------------NDPKWYKMWYLNKMNKEN-SMNIISAWKKGYRGQNVVVSILDDGIEKDHPDLKENYDPNASYDIISNDNNPEPRYISSNNTKIKDNHHGTRCAGQVAATANNRICGVGVAYKANIGGIRMLDGEVSDSVESHSLRLFYQHIDIYSASWGPEDDGKTVDGPGELAKIAFEDGILKGRNGLGSIFVWASGNGGKNHDNCNCDGYTNSIFTLGVNAVSEIGDAPWYAEKCSSTLAVTYSSGSMDERAIITTDVNHECTEQHSGTSASAPFAAGICALALSANRFLTWRDMQHLVVITARKANLRAVD----WSTNAAGKEYSHSFGFGLMDAGAMVDLALNWTTVPEQHICHYVAPMQGGPISLKPYANEVLSITTDACSDNSKKRVRYLEHVQAKISLRSTKRGEVELWLISPSRSTSKLLTKRRNDVASAGFHHWPFMSVHFWGEEAPGTWKLTIYSYD----AEVTLINWSLILYGT 1830
            AR +AA +      +     + F +   + R+          L   P V W+E+Q  K RVKR  +                                          DP +   WYL+        MN+  AW +GY G+NV VSILDDGI++DHPDL  NYDP AS DI  +D++P P+    NN    DN HGTRCAG+VAA A N  CGVGVA+KA IGG+RMLDG VSDSVE+ SL L   HIDIYSASWGPEDDGKT DGPG LA+ AF  GI  GR G G+IFVWASGNGG   D+C+ DGYT S++TL +++ +     PWY E+C S++A TYSS    + AI+T DV   CT++H+GTSASAP AAGI ALAL AN  LTWRDMQHLV+   R AN + ++    WS N  G+  S+ FG+GL+D GA+V++A  W TVPEQHIC Y   +   P          L+ T D     S   V YLEHVQ   ++R  KRG+++L L SPS + S LL  R  D  + GFH WPF+SV  WGE+  GTW L + S      A  T  +W+L+LYGT
Sbjct:   54 ARRIAADHDMHVKGDPFLDTHYFLYHSETTRTRRHKRAIVERLDSHPAVEWVEEQRPKKRVKRDYILLDNDVHHSNPFRRSVLNRDGTRRAQRQQPQSPREIPSLPFPDPLYKDQWYLHGGAVGGYDMNVRQAWLQGYAGRNVSVSILDDGIQRDHPDLAANYDPLASTDINDHDDDPTPQ----NN---GDNKHGTRCAGEVAALAGNNQCGVGVAFKAKIGGVRMLDGAVSDSVEAASLSLNQDHIDIYSASWGPEDDGKTFDGPGPLAREAFYRGIKNGRGGKGNIFVWASGNGGSRQDSCSADGYTTSVYTLSISSATYDNHRPWYLEECPSSIATTYSSADFRQPAIVTVDVPGGCTDKHTGTSASAPLAAGIIALALEANPELTWRDMQHLVL---RTANWKPLENNPGWSRNGVGRMVSNKFGYGLIDGGALVNMAKTWKTVPEQHICTYEYRL-ANPNPRPIVGRFQLNFTLDVNGCESGTPVLYLEHVQVHATVRYLKRGDLKLTLFSPSGTRSVLLPPRPQDFNANGFHKWPFLSVQQWGEDPRGTWLLMVESVTTNPAATGTFHDWTLLLYGT 626

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BLAST of Furin-1 vs. Ensembl Fly
Match: Fur1 (gene:FBgn0004509 transcript:FBtr0336806)

HSP 1 Score: 607.06 bits (1564), Expect = 0.000e+0
Identity = 310/575 (53.91%), Postives = 392/575 (68.17%), Query Frame = 1

Query:  178 GHYTDTWAVQI-NGTVDDARILAATYGFVFLNEIMPSIYSFKHRRVSKRSIYPSNYYQSNLSDDPRVIWLEQQFAKVRVKRHIV--------------------NDPKWYKMWYLNKMNKENSMNIISAWKKGYRGQNVVVSILDDGIEKDHPDLKENYDPNASYDIISNDNNPEPRYISSNNTKIKDNHHGTRCAGQVAATANNRICGVGVAYKANIGGIRMLDGEVSDSVESHSLRLFYQHIDIYSASWGPEDDGKTVDGPGELAKIAFEDGILKGRNGLGSIFVWASGNGGKNHDNCNCDGYTNSIFTLGVNAVSEIGDAPWYAEKCSSTLAVTYSSGSMDERAIITTDVNHECTEQHSGTSASAPFAAGICALALSANRFLTWRDMQHLVVITARKANLRAVDWSTNAAGKEYSHSFGFGLMDAGAMVDLALNWTTVPEQHICHYVAPMQGGPISLKPYANEVLSITTDACSDNSKKRVRYLEHVQAKISLRSTKRGEVELWLISPSRSTSKLLTKRRNDVASAGFHHWPFMSVHFWGEEAPGTWKLTIYS---YDAEVTLINWSLILYGT 1830
            GHYT TWAV I NG    A  +A  +GFV L +I    Y F H +VSKRS+ P+ ++Q+ L DD RV W +QQ AK R KR  +                    ND KW +MWYLN+    + MN+I AWK G  G+ VVV+ILDDG+E DHPD+++NYDP ASYD+ S+D++P P Y  +++     N HGTRCAG+VAATANN  C VG+AY A++GG+RMLDG+V+D+VE+ SL L  QHIDIYSASWGP+DDGKTVDGPGELA  AF +G  KGR G GSIF+WASGNGG+  DNCNCDGYTNSI+TL +++ +E G  PWY+EKCSSTLA TYSSG   E+ ++TTD++H CT  H+GTSASAP AAGI AL L +N+ LTWRD+QH+VV TA+ ANL+   WS N  G+  SHSFG+GLMDA  MV +A NW  VPEQ  C   AP     I   P  +  L +T + C     + V YLEHVQAKI+L S +RG+++L+L SP+ ++  LLT R +D + +GF+ WPFMSVH WGE   G W+L I++   Y     L  WSLI YGT
Sbjct:  229 GHYTHTWAVHIPNGDNGMADAVAKDHGFVNLGKIFDDHYHFAHHKVSKRSLSPATHHQTRLDDDDRVHWAKQQRAKSRSKRDFIRMRPSRTSSRAMSMVDAMSFNDSKWPQMWYLNRGGGLD-MNVIPAWKMGITGKGVVVTILDDGLESDHPDIQDNYDPKASYDVNSHDDDPMPHYDMTDS-----NRHGTRCAGEVAATANNSFCAVGIAYGASVGGVRMLDGDVTDAVEARSLSLNPQHIDIYSASWGPDDDGKTVDGPGELASRAFIEGTTKGRGGKGSIFIWASGNGGREQDNCNCDGYTNSIWTLSISSATEEGHVPWYSEKCSSTLATTYSSGGQGEKQVVTTDLHHSCTVSHTGTSASAPLAAGIAALVLQSNQNLTWRDLQHIVVRTAKPANLKDPSWSRNGVGRRVSHSFGYGLMDAAEMVRVARNWKAVPEQQRCEINAPHVDKVI--PPRTHITLQLTVNHC-----RSVNYLEHVQAKITLTSQRRGDIQLFLRSPANTSVTLLTPRIHDNSRSGFNQWPFMSVHTWGESPQGNWQLEIHNEGRYMGHALLREWSLIFYGT 790

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BLAST of Furin-1 vs. Ensembl Fly
Match: Fur1 (gene:FBgn0004509 transcript:FBtr0089983)

HSP 1 Score: 607.06 bits (1564), Expect = 0.000e+0
Identity = 310/575 (53.91%), Postives = 392/575 (68.17%), Query Frame = 1

Query:  178 GHYTDTWAVQI-NGTVDDARILAATYGFVFLNEIMPSIYSFKHRRVSKRSIYPSNYYQSNLSDDPRVIWLEQQFAKVRVKRHIV--------------------NDPKWYKMWYLNKMNKENSMNIISAWKKGYRGQNVVVSILDDGIEKDHPDLKENYDPNASYDIISNDNNPEPRYISSNNTKIKDNHHGTRCAGQVAATANNRICGVGVAYKANIGGIRMLDGEVSDSVESHSLRLFYQHIDIYSASWGPEDDGKTVDGPGELAKIAFEDGILKGRNGLGSIFVWASGNGGKNHDNCNCDGYTNSIFTLGVNAVSEIGDAPWYAEKCSSTLAVTYSSGSMDERAIITTDVNHECTEQHSGTSASAPFAAGICALALSANRFLTWRDMQHLVVITARKANLRAVDWSTNAAGKEYSHSFGFGLMDAGAMVDLALNWTTVPEQHICHYVAPMQGGPISLKPYANEVLSITTDACSDNSKKRVRYLEHVQAKISLRSTKRGEVELWLISPSRSTSKLLTKRRNDVASAGFHHWPFMSVHFWGEEAPGTWKLTIYS---YDAEVTLINWSLILYGT 1830
            GHYT TWAV I NG    A  +A  +GFV L +I    Y F H +VSKRS+ P+ ++Q+ L DD RV W +QQ AK R KR  +                    ND KW +MWYLN+    + MN+I AWK G  G+ VVV+ILDDG+E DHPD+++NYDP ASYD+ S+D++P P Y  +++     N HGTRCAG+VAATANN  C VG+AY A++GG+RMLDG+V+D+VE+ SL L  QHIDIYSASWGP+DDGKTVDGPGELA  AF +G  KGR G GSIF+WASGNGG+  DNCNCDGYTNSI+TL +++ +E G  PWY+EKCSSTLA TYSSG   E+ ++TTD++H CT  H+GTSASAP AAGI AL L +N+ LTWRD+QH+VV TA+ ANL+   WS N  G+  SHSFG+GLMDA  MV +A NW  VPEQ  C   AP     I   P  +  L +T + C     + V YLEHVQAKI+L S +RG+++L+L SP+ ++  LLT R +D + +GF+ WPFMSVH WGE   G W+L I++   Y     L  WSLI YGT
Sbjct:  229 GHYTHTWAVHIPNGDNGMADAVAKDHGFVNLGKIFDDHYHFAHHKVSKRSLSPATHHQTRLDDDDRVHWAKQQRAKSRSKRDFIRMRPSRTSSRAMSMVDAMSFNDSKWPQMWYLNRGGGLD-MNVIPAWKMGITGKGVVVTILDDGLESDHPDIQDNYDPKASYDVNSHDDDPMPHYDMTDS-----NRHGTRCAGEVAATANNSFCAVGIAYGASVGGVRMLDGDVTDAVEARSLSLNPQHIDIYSASWGPDDDGKTVDGPGELASRAFIEGTTKGRGGKGSIFIWASGNGGREQDNCNCDGYTNSIWTLSISSATEEGHVPWYSEKCSSTLATTYSSGGQGEKQVVTTDLHHSCTVSHTGTSASAPLAAGIAALVLQSNQNLTWRDLQHIVVRTAKPANLKDPSWSRNGVGRRVSHSFGYGLMDAAEMVRVARNWKAVPEQQRCEINAPHVDKVI--PPRTHITLQLTVNHC-----RSVNYLEHVQAKITLTSQRRGDIQLFLRSPANTSVTLLTPRIHDNSRSGFNQWPFMSVHTWGESPQGNWQLEIHNEGRYMGHALLREWSLIFYGT 790

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BLAST of Furin-1 vs. Ensembl Fly
Match: Fur1 (gene:FBgn0004509 transcript:FBtr0089982)

HSP 1 Score: 603.208 bits (1554), Expect = 0.000e+0
Identity = 310/577 (53.73%), Postives = 396/577 (68.63%), Query Frame = 1

Query:  178 GHYTDTWAVQI-NGTVDDARILAATYGFVFLNEIMPSIYSFKHRRVSKRSIYPSNYYQSNLSDDPRVIWLEQQFAKVRVKRHIV--------------------NDPKWYKMWYLNKMNKENSMNIISAWKKGYRGQNVVVSILDDGIEKDHPDLKENYDPNASYDIISNDNNPEPRYISSNNTKIKDNHHGTRCAGQVAATANNRICGVGVAYKANIGGIRMLDGEVSDSVESHSLRLFYQHIDIYSASWGPEDDGKTVDGPGELAKIAFEDGILKGRNGLGSIFVWASGNGGKNHDNCNCDGYTNSIFTLGVNAVSEIGDAPWYAEKCSSTLAVTYSSGSMDERAIITTDVNHECTEQHSGTSASAPFAAGICALALSANRFLTWRDMQHLVVITARKANLRAVDWSTNAAGKEYSHSFGFGLMDAGAMVDLALNWTTVPEQHICHYVAPMQGGPISLKPYANEVLSITTDACSDNSKKRVRYLEHVQAKISLRSTKRGEVELWLISPSRSTSKLLTKRRNDVASAGFHHWPFMSVHFWGEEAPGTWKLTIYS---YDAEVTLINWSLILYGTDT 1836
            GHYT TWAV I NG    A  +A  +GFV L +I    Y F H +VSKRS+ P+ ++Q+ L DD RV W +QQ AK R KR  +                    ND KW +MWYLN+    + MN+I AWK G  G+ VVV+ILDDG+E DHPD+++NYDP ASYD+ S+D++P P Y  +++     N HGTRCAG+VAATANN  C VG+AY A++GG+RMLDG+V+D+VE+ SL L  QHIDIYSASWGP+DDGKTVDGPGELA  AF +G  KGR G GSIF+WASGNGG+  DNCNCDGYTNSI+TL +++ +E G  PWY+EKCSSTLA TYSSG   E+ ++TTD++H CT  H+GTSASAP AAGI AL L +N+ LTWRD+QH+VV TA+ ANL+   WS N  G+  SHSFG+GLMDA  MV +A NW  VPEQ  C   AP     I   P  +  L +T + C     + V YLEHVQAKI+L S +RG+++L+L SP+ ++  LLT R +D + +GF+ WPFMSVH WGE   G W+L I++   Y A++T   W +I YGT+T
Sbjct:  229 GHYTHTWAVHIPNGDNGMADAVAKDHGFVNLGKIFDDHYHFAHHKVSKRSLSPATHHQTRLDDDDRVHWAKQQRAKSRSKRDFIRMRPSRTSSRAMSMVDAMSFNDSKWPQMWYLNRGGGLD-MNVIPAWKMGITGKGVVVTILDDGLESDHPDIQDNYDPKASYDVNSHDDDPMPHYDMTDS-----NRHGTRCAGEVAATANNSFCAVGIAYGASVGGVRMLDGDVTDAVEARSLSLNPQHIDIYSASWGPDDDGKTVDGPGELASRAFIEGTTKGRGGKGSIFIWASGNGGREQDNCNCDGYTNSIWTLSISSATEEGHVPWYSEKCSSTLATTYSSGGQGEKQVVTTDLHHSCTVSHTGTSASAPLAAGIAALVLQSNQNLTWRDLQHIVVRTAKPANLKDPSWSRNGVGRRVSHSFGYGLMDAAEMVRVARNWKAVPEQQRCEINAPHVDKVI--PPRTHITLQLTVNHC-----RSVNYLEHVQAKITLTSQRRGDIQLFLRSPANTSVTLLTPRIHDNSRSGFNQWPFMSVHTWGESPQGNWQLEIHNEGRYMAQIT--QWDMIFYGTET 790

[Close]

BLAST of Furin-1 vs. Ensembl Fly
Match: Fur1 (gene:FBgn0004509 transcript:FBtr0336805)

HSP 1 Score: 601.668 bits (1550), Expect = 0.000e+0
Identity = 310/577 (53.73%), Postives = 396/577 (68.63%), Query Frame = 1

Query:  178 GHYTDTWAVQI-NGTVDDARILAATYGFVFLNEIMPSIYSFKHRRVSKRSIYPSNYYQSNLSDDPRVIWLEQQFAKVRVKRHIV--------------------NDPKWYKMWYLNKMNKENSMNIISAWKKGYRGQNVVVSILDDGIEKDHPDLKENYDPNASYDIISNDNNPEPRYISSNNTKIKDNHHGTRCAGQVAATANNRICGVGVAYKANIGGIRMLDGEVSDSVESHSLRLFYQHIDIYSASWGPEDDGKTVDGPGELAKIAFEDGILKGRNGLGSIFVWASGNGGKNHDNCNCDGYTNSIFTLGVNAVSEIGDAPWYAEKCSSTLAVTYSSGSMDERAIITTDVNHECTEQHSGTSASAPFAAGICALALSANRFLTWRDMQHLVVITARKANLRAVDWSTNAAGKEYSHSFGFGLMDAGAMVDLALNWTTVPEQHICHYVAPMQGGPISLKPYANEVLSITTDACSDNSKKRVRYLEHVQAKISLRSTKRGEVELWLISPSRSTSKLLTKRRNDVASAGFHHWPFMSVHFWGEEAPGTWKLTIYS---YDAEVTLINWSLILYGTDT 1836
            GHYT TWAV I NG    A  +A  +GFV L +I    Y F H +VSKRS+ P+ ++Q+ L DD RV W +QQ AK R KR  +                    ND KW +MWYLN+    + MN+I AWK G  G+ VVV+ILDDG+E DHPD+++NYDP ASYD+ S+D++P P Y  +++     N HGTRCAG+VAATANN  C VG+AY A++GG+RMLDG+V+D+VE+ SL L  QHIDIYSASWGP+DDGKTVDGPGELA  AF +G  KGR G GSIF+WASGNGG+  DNCNCDGYTNSI+TL +++ +E G  PWY+EKCSSTLA TYSSG   E+ ++TTD++H CT  H+GTSASAP AAGI AL L +N+ LTWRD+QH+VV TA+ ANL+   WS N  G+  SHSFG+GLMDA  MV +A NW  VPEQ  C   AP     I   P  +  L +T + C     + V YLEHVQAKI+L S +RG+++L+L SP+ ++  LLT R +D + +GF+ WPFMSVH WGE   G W+L I++   Y A++T   W +I YGT+T
Sbjct:  229 GHYTHTWAVHIPNGDNGMADAVAKDHGFVNLGKIFDDHYHFAHHKVSKRSLSPATHHQTRLDDDDRVHWAKQQRAKSRSKRDFIRMRPSRTSSRAMSMVDAMSFNDSKWPQMWYLNRGGGLD-MNVIPAWKMGITGKGVVVTILDDGLESDHPDIQDNYDPKASYDVNSHDDDPMPHYDMTDS-----NRHGTRCAGEVAATANNSFCAVGIAYGASVGGVRMLDGDVTDAVEARSLSLNPQHIDIYSASWGPDDDGKTVDGPGELASRAFIEGTTKGRGGKGSIFIWASGNGGREQDNCNCDGYTNSIWTLSISSATEEGHVPWYSEKCSSTLATTYSSGGQGEKQVVTTDLHHSCTVSHTGTSASAPLAAGIAALVLQSNQNLTWRDLQHIVVRTAKPANLKDPSWSRNGVGRRVSHSFGYGLMDAAEMVRVARNWKAVPEQQRCEINAPHVDKVI--PPRTHITLQLTVNHC-----RSVNYLEHVQAKITLTSQRRGDIQLFLRSPANTSVTLLTPRIHDNSRSGFNQWPFMSVHTWGESPQGNWQLEIHNEGRYMAQIT--QWDMIFYGTET 790

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BLAST of Furin-1 vs. Ensembl Fly
Match: Fur1 (gene:FBgn0004509 transcript:FBtr0336804)

HSP 1 Score: 601.668 bits (1550), Expect = 0.000e+0
Identity = 310/577 (53.73%), Postives = 396/577 (68.63%), Query Frame = 1

Query:  178 GHYTDTWAVQI-NGTVDDARILAATYGFVFLNEIMPSIYSFKHRRVSKRSIYPSNYYQSNLSDDPRVIWLEQQFAKVRVKRHIV--------------------NDPKWYKMWYLNKMNKENSMNIISAWKKGYRGQNVVVSILDDGIEKDHPDLKENYDPNASYDIISNDNNPEPRYISSNNTKIKDNHHGTRCAGQVAATANNRICGVGVAYKANIGGIRMLDGEVSDSVESHSLRLFYQHIDIYSASWGPEDDGKTVDGPGELAKIAFEDGILKGRNGLGSIFVWASGNGGKNHDNCNCDGYTNSIFTLGVNAVSEIGDAPWYAEKCSSTLAVTYSSGSMDERAIITTDVNHECTEQHSGTSASAPFAAGICALALSANRFLTWRDMQHLVVITARKANLRAVDWSTNAAGKEYSHSFGFGLMDAGAMVDLALNWTTVPEQHICHYVAPMQGGPISLKPYANEVLSITTDACSDNSKKRVRYLEHVQAKISLRSTKRGEVELWLISPSRSTSKLLTKRRNDVASAGFHHWPFMSVHFWGEEAPGTWKLTIYS---YDAEVTLINWSLILYGTDT 1836
            GHYT TWAV I NG    A  +A  +GFV L +I    Y F H +VSKRS+ P+ ++Q+ L DD RV W +QQ AK R KR  +                    ND KW +MWYLN+    + MN+I AWK G  G+ VVV+ILDDG+E DHPD+++NYDP ASYD+ S+D++P P Y  +++     N HGTRCAG+VAATANN  C VG+AY A++GG+RMLDG+V+D+VE+ SL L  QHIDIYSASWGP+DDGKTVDGPGELA  AF +G  KGR G GSIF+WASGNGG+  DNCNCDGYTNSI+TL +++ +E G  PWY+EKCSSTLA TYSSG   E+ ++TTD++H CT  H+GTSASAP AAGI AL L +N+ LTWRD+QH+VV TA+ ANL+   WS N  G+  SHSFG+GLMDA  MV +A NW  VPEQ  C   AP     I   P  +  L +T + C     + V YLEHVQAKI+L S +RG+++L+L SP+ ++  LLT R +D + +GF+ WPFMSVH WGE   G W+L I++   Y A++T   W +I YGT+T
Sbjct:  229 GHYTHTWAVHIPNGDNGMADAVAKDHGFVNLGKIFDDHYHFAHHKVSKRSLSPATHHQTRLDDDDRVHWAKQQRAKSRSKRDFIRMRPSRTSSRAMSMVDAMSFNDSKWPQMWYLNRGGGLD-MNVIPAWKMGITGKGVVVTILDDGLESDHPDIQDNYDPKASYDVNSHDDDPMPHYDMTDS-----NRHGTRCAGEVAATANNSFCAVGIAYGASVGGVRMLDGDVTDAVEARSLSLNPQHIDIYSASWGPDDDGKTVDGPGELASRAFIEGTTKGRGGKGSIFIWASGNGGREQDNCNCDGYTNSIWTLSISSATEEGHVPWYSEKCSSTLATTYSSGGQGEKQVVTTDLHHSCTVSHTGTSASAPLAAGIAALVLQSNQNLTWRDLQHIVVRTAKPANLKDPSWSRNGVGRRVSHSFGYGLMDAAEMVRVARNWKAVPEQQRCEINAPHVDKVI--PPRTHITLQLTVNHC-----RSVNYLEHVQAKITLTSQRRGDIQLFLRSPANTSVTLLTPRIHDNSRSGFNQWPFMSVHTWGESPQGNWQLEIHNEGRYMAQIT--QWDMIFYGTET 790

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BLAST of Furin-1 vs. Ensembl Zebrafish
Match: furina (furin (paired basic amino acid cleaving enzyme) a [Source:ZFIN;Acc:ZDB-GENE-040901-1])

HSP 1 Score: 582.408 bits (1500), Expect = 0.000e+0
Identity = 300/571 (52.54%), Postives = 391/571 (68.48%), Query Frame = 1

Query:  184 YTDTWAVQINGTVDDARILAATYGFVFLNEIMPSIYSFKHRRVSKRSIYPSNYYQSNLSDDPRVIWLEQQFAKVRVKRHIV---NDPKWYKMWYLNKMNKENSMNIISAWKKGYRGQNVVVSILDDGIEKDHPDLKENYDPNASYDIISNDNNPEPRYISSNNTKIKDNHHGTRCAGQVAATANNRICGVGVAYKANIGGIRMLDGEVSDSVESHSLRLFYQHIDIYSASWGPEDDGKTVDGPGELAKIAFEDGILKGRNGLGSIFVWASGNGGKNHDNCNCDGYTNSIFTLGVNAVSEIGDAPWYAEKCSSTLAVTYSSGSMDERAIITTDVNHECTEQHSGTSASAPFAAGICALALSANRFLTWRDMQHLVVITARKANLRAVDWSTNAAGKEYSHSFGFGLMDAGAMVDLALNWTTVPEQHICHYVAPMQGGPISLKPYANEVLSITTDACSDNSKKRVRYLEHVQAKISLRSTKRGEVELWLISPSRSTSKLLTKRRNDVASAGFHHWPFMSVHFWGEEAPGTWKLTIYSYDAEV---TLINWSLILYGTDTLPSHRQNSTHTKSQ 1878
            YT+TWAV I G  ++A  +A  + FV    +    Y F+HR V KRS+         L  +P+V+W EQQ  K R KR +     DPK+ + WYL   +  + +N+ +AWK+G  GQ VVVSILDDGIEK+HPDL +NYDP+ASYD+   D +P+PRY     T++ DN HGTRCAG+VAA A+N ICGVGVAY A IGG+RMLDGEV+D VE+ SL L  QHIDIYSASWGPEDDGKTVDGP +LAK AF+ G+++GR G GSIFVWASGNGG+  D+CNCDGYTNSI+TL +++ ++ G+ PWY+E CSSTLA TYSSG ++E+ I+TTD+  +CT+ H+GTSASAP AAGI ALAL AN+ LTWRDMQHLVV T+  A+L   DW  N  G+  SHS+G+GL+DAGA+V LA NWT V  QH C  V  +   P ++  Y   V++ T DAC+  +   V  LEHVQA+++L   +RG + ++LISP  + S LL  R +D +S GF+ W FM+ H W E+  G W L I +        TL  ++L+LYGT +  S  ++ST   SQ
Sbjct:   30 YTNTWAVHIEGGEEEADRIARKHSFVNHGNVFGDYYHFRHRTVVKRSLSEHRGTHIRLHTEPQVMWAEQQVVKRRKKRDVYYEPTDPKFAQQWYLYNQDHLD-LNVKNAWKQGVTGQGVVVSILDDGIEKNHPDLVQNYDPDASYDVNDGDPDPQPRY-----TQLNDNRHGTRCAGEVAAVADNDICGVGVAYNARIGGVRMLDGEVTDVVEAQSLSLNPQHIDIYSASWGPEDDGKTVDGPAKLAKEAFQRGVIEGRGGRGSIFVWASGNGGRMKDSCNCDGYTNSIYTLSISSSTQNGNVPWYSEACSSTLASTYSSGGVNEKQIVTTDLRQKCTDSHTGTSASAPLAAGIIALALEANKNLTWRDMQHLVVRTSNPAHLTTNDWKINGVGRRVSHSYGYGLLDAGAIVALAKNWTNVGPQHKC--VLSLVSEPRNIGSYL--VINKTVDACTGMA-NFVSSLEHVQAQLTLSYNRRGNLAIYLISPQGTRSTLLPPRPHDYSSEGFNDWAFMTTHSWDEDPRGEWTLEIKNVAGTSDYGTLTQFTLVLYGTAS--SLSRSSTAGSSQ 587

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Query:  184 YTDTWAVQINGTVDDARILAATYGFVFLNEIMPSIYSFKHRRVSKRSIYPSNYYQSNLSDDPRVIWLEQQFAKVRVKRHIV---NDPKWYKMWYLNKMNKENSMNIISAWKKGYRGQNVVVSILDDGIEKDHPDLKENYDPNASYDIISNDNNPEPRYISSNNTKIKDNHHGTRCAGQVAATANNRICGVGVAYKANIGGIRMLDGEVSDSVESHSLRLFYQHIDIYSASWGPEDDGKTVDGPGELAKIAFEDGILKGRNGLGSIFVWASGNGGKNHDNCNCDGYTNSIFTLGVNAVSEIGDAPWYAEKCSSTLAVTYSSGSMDERAIITTDVNHECTEQHSGTSASAPFAAGICALALSANRFLTWRDMQHLVVITARKANLRAVDWSTNAAGKEYSHSFGFGLMDAGAMVDLALNWTTVPEQHICHYVAPMQGGPISLKPYANEVLSITTDACSDNSKKRVRYLEHVQAKISLRSTKRGEVELWLISPSRSTSKLLTKRRNDVASAGFHHWPFMSVHFWGEEAPGTWKLTIYSYDAEV---TLINWSLILYGTDTLPSHRQNSTHTKSQ 1878
            YT+TWAV I G  ++A  +A  + FV    +    Y F+HR V KRS+         L  +P+V+W EQQ  K R KR +     DPK+ + WYL   +  + +N+ +AWK+G  GQ VVVSILDDGIEK+HPDL +NYDP+ASYD+   D +P+PRY     T++ DN HGTRCAG+VAA A+N ICGVGVAY A IGG+RMLDGEV+D VE+ SL L  QHIDIYSASWGPEDDGKTVDGP +LAK AF+ G+++GR G GSIFVWASGNGG+  D+CNCDGYTNSI+TL +++ ++ G+ PWY+E CSSTLA TYSSG ++E+ I+TTD+  +CT+ H+GTSASAP AAGI ALAL AN+ LTWRDMQHLVV T+  A+L   DW  N  G+  SHS+G+GL+DAGA+V LA NWT V  QH C  V  +   P ++  Y   V++ T DAC+  +   V  LEHVQA+++L   +RG + ++LISP  + S LL  R +D +S GF+ W FM+ H W E+  G W L I +        TL  ++L+LYGT +  S  ++ST   SQ
Sbjct:   30 YTNTWAVHIEGGEEEADRIARKHSFVNHGNVFGDYYHFRHRTVVKRSLSEHRGTHIRLHTEPQVMWAEQQVVKRRKKRDVYYEPTDPKFAQQWYLYNQDHLD-LNVKNAWKQGVTGQGVVVSILDDGIEKNHPDLVQNYDPDASYDVNDGDPDPQPRY-----TQLNDNRHGTRCAGEVAAVADNDICGVGVAYNARIGGVRMLDGEVTDVVEAQSLSLNPQHIDIYSASWGPEDDGKTVDGPAKLAKEAFQRGVIEGRGGRGSIFVWASGNGGRMKDSCNCDGYTNSIYTLSISSSTQNGNVPWYSEACSSTLASTYSSGGVNEKQIVTTDLRQKCTDSHTGTSASAPLAAGIIALALEANKNLTWRDMQHLVVRTSNPAHLTTNDWKINGVGRRVSHSYGYGLLDAGAIVALAKNWTNVGPQHKC--VLSLVSEPRNIGSYL--VINKTVDACTGMA-NFVSSLEHVQAQLTLSYNRRGNLAIYLISPQGTRSTLLPPRPHDYSSEGFNDWAFMTTHSWDEDPRGEWTLEIKNVAGTSDYGTLTQFTLVLYGTAS--SLSRSSTAGSSQ 587

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Query:  184 YTDTWAVQINGTVDDARILAATYGFVFLNEIMPSIYSFKHRRVSKRSIYPSNYYQSNLSDDPRVIWLEQQFAKVRVKRHIV---NDPKWYKMWYLNKMNKENSMNIISAWKKGYRGQNVVVSILDDGIEKDHPDLKENYDPNASYDIISNDNNPEPRYISSNNTKIKDNHHGTRCAGQVAATANNRICGVGVAYKANIGGIRMLDGEVSDSVESHSLRLFYQHIDIYSASWGPEDDGKTVDGPGELAKIAFEDGILKGRNGLGSIFVWASGNGGKNHDNCNCDGYTNSIFTLGVNAVSEIGDAPWYAEKCSSTLAVTYSSGSMDERAIITTDVNHECTEQHSGTSASAPFAAGICALALSANRFLTWRDMQHLVVITARKANLRAVDWSTNAAGKEYSHSFGFGLMDAGAMVDLALNWTTVPEQHICHYVAPMQGGPISLKPYANEVLSITTDACSDNSKKRVRYLEHVQAKISLRSTKRGEVELWLISPSRSTSKLLTKRRNDVASAGFHHWPFMSVHFWGEEAPGTWKLTIYSYDAEV---TLINWSLILYGTDTLPSHRQNSTHTKSQ 1878
            YT+TWAV I G  ++A  +A  + FV    +    Y F+HR V KRS+         L  +P+V+W EQQ  K R KR +     DPK+ + WYL   +  + +N+ +AWK+G  GQ VVVSILDDGIEK+HPDL +NYDP+ASYD+   D +P+PRY     T++ DN HGTRCAG+VAA A+N ICGVGVAY A IGG+RMLDGEV+D VE+ SL L  QHIDIYSASWGPEDDGKTVDGP +LAK AF+ G+++GR G GSIFVWASGNGG+  D+CNCDGYTNSI+TL +++ ++ G+ PWY+E CSSTLA TYSSG ++E+ I+TTD+  +CT+ H+GTSASAP AAGI ALAL AN+ LTWRDMQHLVV T+  A+L   DW  N  G+  SHS+G+GL+DAGA+V LA NWT V  QH C  V  +   P ++  Y   V++ T DAC+  +   V  LEHVQA+++L   +RG + ++LISP  + S LL  R +D +S GF+ W FM+ H W E+  G W L I +        TL  ++L+LYGT +  S  ++ST   SQ
Sbjct:   30 YTNTWAVHIEGGEEEADRIARKHSFVNHGNVFGDYYHFRHRTVVKRSLSEHRGTHIRLHTEPQVMWAEQQVVKRRKKRDVYYEPTDPKFAQQWYLYNQDHLD-LNVKNAWKQGVTGQGVVVSILDDGIEKNHPDLVQNYDPDASYDVNDGDPDPQPRY-----TQLNDNRHGTRCAGEVAAVADNDICGVGVAYNARIGGVRMLDGEVTDVVEAQSLSLNPQHIDIYSASWGPEDDGKTVDGPAKLAKEAFQRGVIEGRGGRGSIFVWASGNGGRMKDSCNCDGYTNSIYTLSISSSTQNGNVPWYSEACSSTLASTYSSGGVNEKQIVTTDLRQKCTDSHTGTSASAPLAAGIIALALEANKNLTWRDMQHLVVRTSNPAHLTTNDWKINGVGRRVSHSYGYGLLDAGAIVALAKNWTNVGPQHKC--VLSLVSEPRNIGSYL--VINKTVDACTGMA-NFVSSLEHVQAQLTLSYNRRGNLAIYLISPQGTRSTLLPPRPHDYSSEGFNDWAFMTTHSWDEDPRGEWTLEIKNVAGTSDYGTLTQFTLVLYGTAS--SLSRSSTAGSSQ 587

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BLAST of Furin-1 vs. Ensembl Zebrafish
Match: furinb (furin (paired basic amino acid cleaving enzyme) b [Source:ZFIN;Acc:ZDB-GENE-040901-2])

HSP 1 Score: 580.867 bits (1496), Expect = 0.000e+0
Identity = 298/572 (52.10%), Postives = 385/572 (67.31%), Query Frame = 1

Query:  175 RGHYTDTWAVQINGTVDDARILAATYGFVFLNEIMPSIYSFKHRRVSKRSIYPSNYYQSNLSDDPRVIWLEQQFAKVRVKRHI---VNDPKWYKMWYLNKMNKENSMNIISAWKKGYRGQNVVVSILDDGIEKDHPDLKENYDPNASYDIISNDNNPEPRYISSNNTKIKDNHHGTRCAGQVAATANNRICGVGVAYKANIGGIRMLDGEVSDSVESHSLRLFYQHIDIYSASWGPEDDGKTVDGPGELAKIAFEDGILKGRNGLGSIFVWASGNGGKNHDNCNCDGYTNSIFTLGVNAVSEIGDAPWYAEKCSSTLAVTYSSGSMDERAIITTDVNHECTEQHSGTSASAPFAAGICALALSANRFLTWRDMQHLVVITARKANLRAVDWSTNAAGKEYSHSFGFGLMDAGAMVDLALNWTTVPEQHICHYVAPMQGGPISLKPYANEVLSITTDACSDNSKKRVRYLEHVQAKISLRSTKRGEVELWLISPSRSTSKLLTKRRNDVASAGFHHWPFMSVHFWGEEAPGTWKLTI---YSYDAEVTLINWSLILYGTDTLPSHRQNSTHTK 1872
            +G Y +TWAV I G V++A  +A  +GFV   ++    Y F+HR V +RS+         L  +P+V+W EQQ AK R KR I     DPK+ + WYL   +    +N+  AW +G+ G+ VVV+ILDDGIEKDHPDL +NYDP+ASYD+   D +P+PRY     T++ DN HGTRCAG+VAA ANN +CGVGVAY A IGG+RMLDGEV+D VE+ SL L  QHI IYSASWGPEDDGKTVDGP +LAK AF  G+ +GR+GLGSIFVWASGNGG+  D+CNCDGYTNSI+TL +++ ++ G  PWY+E CSSTLA TYSSG+++E+ I+TTD+  +CT+ H+GTSASAP AAGI ALAL AN  LTWRDMQHLVV T+R A+L   DW TN  G+  SHS+G+GL+DA AMV LA NWT++  QH C  V  M   P  +K +     S + +ACS      V  LEHVQA+++L    RG + + LISP  + S LL  R  D ++ GF+ W FM+ H W E+  G W L I      +    L  ++LILYGT +  +    S +T+
Sbjct:   28 QGIYINTWAVHIEGGVEEAERIAQKHGFVSHGQVFGDFYHFQHRGVVRRSLSSHRGVHVRLHTEPQVLWAEQQIAKRRRKRDIHMEPTDPKFPQQWYLYNPS-HGDLNVKEAWAQGFTGRGVVVTILDDGIEKDHPDLAKNYDPDASYDVNDRDPDPQPRY-----TQLNDNRHGTRCAGEVAAAANNGVCGVGVAYNAKIGGVRMLDGEVTDVVEAQSLSLNSQHIHIYSASWGPEDDGKTVDGPAKLAKEAFLQGVTEGRSGLGSIFVWASGNGGRERDSCNCDGYTNSIYTLSISSTTQYGSVPWYSEACSSTLATTYSSGNLNEKQIVTTDLRKKCTDSHTGTSASAPLAAGIIALALEANMNLTWRDMQHLVVRTSRPAHLITNDWRTNGVGRLVSHSYGYGLLDATAMVALAQNWTSMGPQHKC--VINMLTEPRDIKNHL--TFSRSVEACS-GQPDFVSSLEHVQARLTLSYNHRGNLAVHLISPLGTRSTLLAPRPQDNSAEGFNDWAFMTTHSWDEDPRGEWTLEIENVAGLNDYGVLSQFTLILYGTGSSATDPSVSDYTR 588

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BLAST of Furin-1 vs. Ensembl Zebrafish
Match: CR383678.1 (proprotein convertase subtilisin/kexin type 5a [Source:NCBI gene;Acc:571235])

HSP 1 Score: 569.696 bits (1467), Expect = 0.000e+0
Identity = 292/593 (49.24%), Postives = 381/593 (64.25%), Query Frame = 1

Query:  121 VILFSSLFCFGAKSQSESRGHYTDTWAVQINGTVDDARILAATYGFVFLNEI--MPSIYSFKHRRVSKRSIYPSNYYQSNLSDDPRVIWLEQQFAKVRVKRHIV---------NDPKWYKMWYLN-KMNKENSMNIISAWKKGYRGQNVVVSILDDGIEKDHPDLKENYDPNASYDIISNDNNPEPRYISSNNTKIKDNHHGTRCAGQVAATANNRICGVGVAYKANIGGIRMLDGEVSDSVESHSLRLFYQHIDIYSASWGPEDDGKTVDGPGELAKIAFEDGILKGRNGLGSIFVWASGNGGKNHDNCNCDGYTNSIFTLGVNAVSEIGDAPWYAEKCSSTLAVTYSSGSMDERAIITTDVNHECTEQHSGTSASAPFAAGICALALSANRFLTWRDMQHLVVITARKANLRAVDWSTNAAGKEYSHSFGFGLMDAGAMVDLALNWTTVPEQHICHYVAPMQGGPISLKPYANEVLSITTDACSDNSKKRVRYLEHVQAKISLRSTKRGEVELWLISPSRSTSKLLTKRRNDVASAGFHHWPFMSVHFWGEEAPGTWKLTIYSYDA-------EVTLINWSLILYGTDTLP 1842
             I F     FG   Q      YT+ WAV+I G  + A ++A  YGFV + +I  +   Y F+H  + KRS   S    S ++ + +V W++QQ  + RVKR            NDPKW  MWY++   N    MNI +AW++GY G+ VVVSILDDGIE+ HPDLK+NYD  ASYD+  ND +P PRY  +N     +N HGTRCAG VAA+ANN +C VG+AY A IGG+RMLDG+++D VE+ SL L  Q+IDIYS+SWGP+DDG+TVDGPG LA++A E+GI KGR G GSIFVWASGNGG++ D+C+CDGYTNSI+T+ V + ++ G  PWY E+CSSTLA TYSSG      ++TTD+   CT++HSGTSASAP AAGI AL L AN  LTWRD+QH++V T+ + +L A DW +N AG + SH +GFGL++A AMV  A  W  VP QHIC          IS +     VL   +  CS    +RV YLEHV  ++++    RG++ + L SPS +TS+LL  R ND +S GF  W FM+ H WGE + G W L I    +       +  L+ WSL+LYGT T P
Sbjct:    4 TIFFPYALFFGIGLQCVQMRLYTNRWAVKITGGPEAADLIAEKYGFVNMGQIGGLVDHYQFQHSGIIKRSTIKSKGNHSLITMETKVEWIQQQMVQKRVKRTETMDQTHDGSFNDPKWDSMWYIHCDHNCLTDMNIQAAWRRGYTGKGVVVSILDDGIERQHPDLKQNYDARASYDVNGNDPDPTPRYDVTN-----ENKHGTRCAGVVAASANNSLCIVGIAYNAKIGGVRMLDGDMTDMVEAQSLNLRQQYIDIYSSSWGPDDDGRTVDGPGPLARLALENGIRKGRKGRGSIFVWASGNGGQSQDHCSCDGYTNSIYTISVGSTTQSGRKPWYLEECSSTLATTYSSGDSHSPGVVTTDLRQRCTDEHSGTSASAPMAAGIIALTLEANPALTWRDIQHIIVKTSSRGHLSASDWQSNGAGYDVSHLYGFGLLNAEAMVKNAETWKQVPSQHICEENIGQNARIISPERVLRSVLK--SSGCSAQRLQRVVYLEHVIVRVTITHPHRGDLSITLTSPSGTTSQLLANRPNDHSSEGFIKWEFMTTHCWGERSAGDWILDIRDTPSPQRNTRLQGKLVEWSLVLYGTSTHP 589

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BLAST of Furin-1 vs. Ensembl Xenopus
Match: gdap1l1 (ganglioside induced differentiation associated protein 1-like 1 [Source:Xenbase;Acc:XB-GENE-950543])

HSP 1 Score: 594.734 bits (1532), Expect = 0.000e+0
Identity = 299/587 (50.94%), Postives = 399/587 (67.97%), Query Frame = 1

Query:  175 RGHYTDTWAVQINGTVDDARILAATYGFVFLNEI--MPSIYSFKHRRVSKRSIYPSNYYQSNLSDDPRVIWLEQQFAKVRVKRHI--------VNDPKWYKMWYLNKMNK----ENSMNIISAWKKGYRGQNVVVSILDDGIEKDHPDLKENYDPNASYDIISNDNNPEPRYISSNNTKIKDNHHGTRCAGQVAATANNRICGVGVAYKANIGGIRMLDGEVSDSVESHSLRLFYQHIDIYSASWGPEDDGKTVDGPGELAKIAFEDGILKGRNGLGSIFVWASGNGGKNHDNCNCDGYTNSIFTLGVNAVSEIGDAPWYAEKCSSTLAVTYSSGSMDERAIITTDVNHECTEQHSGTSASAPFAAGICALALSANRFLTWRDMQHLVVITARKANLRAVDWSTNAAGKEYSHSFGFGLMDAGAMVDLALNWTTVPEQHICHYVAPMQGGPISLKPYANEVLSITTDACSDNSKKRVRYLEHVQAKISLRSTKRGEVELWLISPSRSTSKLLTKRRNDVASAGFHHWPFMSVHFWGEEAPGTWKLTIYSYDAEV-------TLINWSLILYGTDTLPSHRQNSTHTK 1872
            R  +++ WAV+I G  + A  LAA YG++ L +I  + + Y F H R  KRS Y S    S L   P+V W++QQ  K RVKRH+         NDP W  MWYL+  +K     + MN++SAW++GY G+NVVVSILDDG+EK+HPDL +NYDP+AS+D+  +D +P PRY +SN     +N HGTRCAG+VAA+ANN  C VG+AY A IGGIRMLDG+V+D VE+ SL +   +IDIYS+SWGP+DDGKTVDGPG LA+ AFEDGI KGR GLGSIFVWASGNGG+  D C+CDGYTNSI+T+ +++ +E G  PWY E+C+STLA TYSSG+  ER I+TTD+   CT+ H+GTS SAP  AG+ ALAL AN  L WRD+QHL+V T+R  +LRA DW TN AG++ SH +GFGL+DA AMV  A  W TVP QH+C  +      P  ++       +  T+AC DN+   V YLEHV  ++++   +RG+++++LISPS + S+LL KR  D ++ GF +W FM+VH WGE+A G W L I+   +++        L  W+LI YGT   P +   + H++
Sbjct:   22 RTVFSNHWAVRIPGGPEVAAELAAQYGYLSLGQIGNLENYYHFYHSRTIKRSTYASRGTHSFLRMHPKVEWMQQQEVKKRVKRHVRTDPNLVNFNDPIWPNMWYLHCSDKSSRCRSEMNVMSAWQRGYTGKNVVVSILDDGVEKNHPDLIQNYDPHASHDVNGDDQDPSPRYDASN-----ENKHGTRCAGEVAASANNSHCIVGIAYNARIGGIRMLDGDVTDVVEAKSLGVRPDYIDIYSSSWGPDDDGKTVDGPGPLARKAFEDGIKKGRKGLGSIFVWASGNGGREGDYCSCDGYTNSIYTISISSTTENGYKPWYLEECASTLATTYSSGAFYERKIVTTDLRQGCTDDHTGTSVSAPMVAGVIALALEANPVLNWRDVQHLLVKTSRSVHLRAPDWKTNGAGRKVSHLYGFGLVDADAMVVEAKKWRTVPPQHVC--IGASDRRPRFIRAVQLIRTTTQTNACVDNAGHYVAYLEHVVVRVTISHPRRGDLQIYLISPSGTKSQLLAKRTFDSSNEGFKNWEFMTVHCWGEKAEGEWTLEIHDSSSQLRNPEIQGKLKEWTLIFYGTSEHPYNHIGTQHSR 601

[Close]

BLAST of Furin-1 vs. Ensembl Xenopus
Match: gdap1l1 (ganglioside induced differentiation associated protein 1-like 1 [Source:Xenbase;Acc:XB-GENE-950543])

HSP 1 Score: 594.349 bits (1531), Expect = 0.000e+0
Identity = 299/587 (50.94%), Postives = 399/587 (67.97%), Query Frame = 1

Query:  175 RGHYTDTWAVQINGTVDDARILAATYGFVFLNEI--MPSIYSFKHRRVSKRSIYPSNYYQSNLSDDPRVIWLEQQFAKVRVKRHI--------VNDPKWYKMWYLNKMNK----ENSMNIISAWKKGYRGQNVVVSILDDGIEKDHPDLKENYDPNASYDIISNDNNPEPRYISSNNTKIKDNHHGTRCAGQVAATANNRICGVGVAYKANIGGIRMLDGEVSDSVESHSLRLFYQHIDIYSASWGPEDDGKTVDGPGELAKIAFEDGILKGRNGLGSIFVWASGNGGKNHDNCNCDGYTNSIFTLGVNAVSEIGDAPWYAEKCSSTLAVTYSSGSMDERAIITTDVNHECTEQHSGTSASAPFAAGICALALSANRFLTWRDMQHLVVITARKANLRAVDWSTNAAGKEYSHSFGFGLMDAGAMVDLALNWTTVPEQHICHYVAPMQGGPISLKPYANEVLSITTDACSDNSKKRVRYLEHVQAKISLRSTKRGEVELWLISPSRSTSKLLTKRRNDVASAGFHHWPFMSVHFWGEEAPGTWKLTIYSYDAEV-------TLINWSLILYGTDTLPSHRQNSTHTK 1872
            R  +++ WAV+I G  + A  LAA YG++ L +I  + + Y F H R  KRS Y S    S L   P+V W++QQ  K RVKRH+         NDP W  MWYL+  +K     + MN++SAW++GY G+NVVVSILDDG+EK+HPDL +NYDP+AS+D+  +D +P PRY +SN     +N HGTRCAG+VAA+ANN  C VG+AY A IGGIRMLDG+V+D VE+ SL +   +IDIYS+SWGP+DDGKTVDGPG LA+ AFEDGI KGR GLGSIFVWASGNGG+  D C+CDGYTNSI+T+ +++ +E G  PWY E+C+STLA TYSSG+  ER I+TTD+   CT+ H+GTS SAP  AG+ ALAL AN  L WRD+QHL+V T+R  +LRA DW TN AG++ SH +GFGL+DA AMV  A  W TVP QH+C  +      P  ++       +  T+AC DN+   V YLEHV  ++++   +RG+++++LISPS + S+LL KR  D ++ GF +W FM+VH WGE+A G W L I+   +++        L  W+LI YGT   P +   + H++
Sbjct:   43 RTVFSNHWAVRIPGGPEVAAELAAQYGYLSLGQIGNLENYYHFYHSRTIKRSTYASRGTHSFLRMHPKVEWMQQQEVKKRVKRHVRTDPNLVNFNDPIWPNMWYLHCSDKSSRCRSEMNVMSAWQRGYTGKNVVVSILDDGVEKNHPDLIQNYDPHASHDVNGDDQDPSPRYDASN-----ENKHGTRCAGEVAASANNSHCIVGIAYNARIGGIRMLDGDVTDVVEAKSLGVRPDYIDIYSSSWGPDDDGKTVDGPGPLARKAFEDGIKKGRKGLGSIFVWASGNGGREGDYCSCDGYTNSIYTISISSTTENGYKPWYLEECASTLATTYSSGAFYERKIVTTDLRQGCTDDHTGTSVSAPMVAGVIALALEANPVLNWRDVQHLLVKTSRSVHLRAPDWKTNGAGRKVSHLYGFGLVDADAMVVEAKKWRTVPPQHVC--IGASDRRPRFIRAVQLIRTTTQTNACVDNAGHYVAYLEHVVVRVTISHPRRGDLQIYLISPSGTKSQLLAKRTFDSSNEGFKNWEFMTVHCWGEKAEGEWTLEIHDSSSQLRNPEIQGKLKEWTLIFYGTSEHPYNHIGTQHSR 622

[Close]

BLAST of Furin-1 vs. Ensembl Xenopus
Match: gdap1l1 (ganglioside induced differentiation associated protein 1-like 1 [Source:Xenbase;Acc:XB-GENE-950543])

HSP 1 Score: 594.349 bits (1531), Expect = 0.000e+0
Identity = 299/587 (50.94%), Postives = 399/587 (67.97%), Query Frame = 1

Query:  175 RGHYTDTWAVQINGTVDDARILAATYGFVFLNEI--MPSIYSFKHRRVSKRSIYPSNYYQSNLSDDPRVIWLEQQFAKVRVKRHI--------VNDPKWYKMWYLNKMNK----ENSMNIISAWKKGYRGQNVVVSILDDGIEKDHPDLKENYDPNASYDIISNDNNPEPRYISSNNTKIKDNHHGTRCAGQVAATANNRICGVGVAYKANIGGIRMLDGEVSDSVESHSLRLFYQHIDIYSASWGPEDDGKTVDGPGELAKIAFEDGILKGRNGLGSIFVWASGNGGKNHDNCNCDGYTNSIFTLGVNAVSEIGDAPWYAEKCSSTLAVTYSSGSMDERAIITTDVNHECTEQHSGTSASAPFAAGICALALSANRFLTWRDMQHLVVITARKANLRAVDWSTNAAGKEYSHSFGFGLMDAGAMVDLALNWTTVPEQHICHYVAPMQGGPISLKPYANEVLSITTDACSDNSKKRVRYLEHVQAKISLRSTKRGEVELWLISPSRSTSKLLTKRRNDVASAGFHHWPFMSVHFWGEEAPGTWKLTIYSYDAEV-------TLINWSLILYGTDTLPSHRQNSTHTK 1872
            R  +++ WAV+I G  + A  LAA YG++ L +I  + + Y F H R  KRS Y S    S L   P+V W++QQ  K RVKRH+         NDP W  MWYL+  +K     + MN++SAW++GY G+NVVVSILDDG+EK+HPDL +NYDP+AS+D+  +D +P PRY +SN     +N HGTRCAG+VAA+ANN  C VG+AY A IGGIRMLDG+V+D VE+ SL +   +IDIYS+SWGP+DDGKTVDGPG LA+ AFEDGI KGR GLGSIFVWASGNGG+  D C+CDGYTNSI+T+ +++ +E G  PWY E+C+STLA TYSSG+  ER I+TTD+   CT+ H+GTS SAP  AG+ ALAL AN  L WRD+QHL+V T+R  +LRA DW TN AG++ SH +GFGL+DA AMV  A  W TVP QH+C  +      P  ++       +  T+AC DN+   V YLEHV  ++++   +RG+++++LISPS + S+LL KR  D ++ GF +W FM+VH WGE+A G W L I+   +++        L  W+LI YGT   P +   + H++
Sbjct:   31 RTVFSNHWAVRIPGGPEVAAELAAQYGYLSLGQIGNLENYYHFYHSRTIKRSTYASRGTHSFLRMHPKVEWMQQQEVKKRVKRHVRTDPNLVNFNDPIWPNMWYLHCSDKSSRCRSEMNVMSAWQRGYTGKNVVVSILDDGVEKNHPDLIQNYDPHASHDVNGDDQDPSPRYDASN-----ENKHGTRCAGEVAASANNSHCIVGIAYNARIGGIRMLDGDVTDVVEAKSLGVRPDYIDIYSSSWGPDDDGKTVDGPGPLARKAFEDGIKKGRKGLGSIFVWASGNGGREGDYCSCDGYTNSIYTISISSTTENGYKPWYLEECASTLATTYSSGAFYERKIVTTDLRQGCTDDHTGTSVSAPMVAGVIALALEANPVLNWRDVQHLLVKTSRSVHLRAPDWKTNGAGRKVSHLYGFGLVDADAMVVEAKKWRTVPPQHVC--IGASDRRPRFIRAVQLIRTTTQTNACVDNAGHYVAYLEHVVVRVTISHPRRGDLQIYLISPSGTKSQLLAKRTFDSSNEGFKNWEFMTVHCWGEKAEGEWTLEIHDSSSQLRNPEIQGKLKEWTLIFYGTSEHPYNHIGTQHSR 610

[Close]

BLAST of Furin-1 vs. Ensembl Xenopus
Match: gdap1l1 (ganglioside induced differentiation associated protein 1-like 1 [Source:Xenbase;Acc:XB-GENE-950543])

HSP 1 Score: 593.964 bits (1530), Expect = 0.000e+0
Identity = 299/587 (50.94%), Postives = 399/587 (67.97%), Query Frame = 1

Query:  175 RGHYTDTWAVQINGTVDDARILAATYGFVFLNEI--MPSIYSFKHRRVSKRSIYPSNYYQSNLSDDPRVIWLEQQFAKVRVKRHI--------VNDPKWYKMWYLNKMNK----ENSMNIISAWKKGYRGQNVVVSILDDGIEKDHPDLKENYDPNASYDIISNDNNPEPRYISSNNTKIKDNHHGTRCAGQVAATANNRICGVGVAYKANIGGIRMLDGEVSDSVESHSLRLFYQHIDIYSASWGPEDDGKTVDGPGELAKIAFEDGILKGRNGLGSIFVWASGNGGKNHDNCNCDGYTNSIFTLGVNAVSEIGDAPWYAEKCSSTLAVTYSSGSMDERAIITTDVNHECTEQHSGTSASAPFAAGICALALSANRFLTWRDMQHLVVITARKANLRAVDWSTNAAGKEYSHSFGFGLMDAGAMVDLALNWTTVPEQHICHYVAPMQGGPISLKPYANEVLSITTDACSDNSKKRVRYLEHVQAKISLRSTKRGEVELWLISPSRSTSKLLTKRRNDVASAGFHHWPFMSVHFWGEEAPGTWKLTIYSYDAEV-------TLINWSLILYGTDTLPSHRQNSTHTK 1872
            R  +++ WAV+I G  + A  LAA YG++ L +I  + + Y F H R  KRS Y S    S L   P+V W++QQ  K RVKRH+         NDP W  MWYL+  +K     + MN++SAW++GY G+NVVVSILDDG+EK+HPDL +NYDP+AS+D+  +D +P PRY +SN     +N HGTRCAG+VAA+ANN  C VG+AY A IGGIRMLDG+V+D VE+ SL +   +IDIYS+SWGP+DDGKTVDGPG LA+ AFEDGI KGR GLGSIFVWASGNGG+  D C+CDGYTNSI+T+ +++ +E G  PWY E+C+STLA TYSSG+  ER I+TTD+   CT+ H+GTS SAP  AG+ ALAL AN  L WRD+QHL+V T+R  +LRA DW TN AG++ SH +GFGL+DA AMV  A  W TVP QH+C  +      P  ++       +  T+AC DN+   V YLEHV  ++++   +RG+++++LISPS + S+LL KR  D ++ GF +W FM+VH WGE+A G W L I+   +++        L  W+LI YGT   P +   + H++
Sbjct:   27 RTVFSNHWAVRIPGGPEVAAELAAQYGYLSLGQIGNLENYYHFYHSRTIKRSTYASRGTHSFLRMHPKVEWMQQQEVKKRVKRHVRTDPNLVNFNDPIWPNMWYLHCSDKSSRCRSEMNVMSAWQRGYTGKNVVVSILDDGVEKNHPDLIQNYDPHASHDVNGDDQDPSPRYDASN-----ENKHGTRCAGEVAASANNSHCIVGIAYNARIGGIRMLDGDVTDVVEAKSLGVRPDYIDIYSSSWGPDDDGKTVDGPGPLARKAFEDGIKKGRKGLGSIFVWASGNGGREGDYCSCDGYTNSIYTISISSTTENGYKPWYLEECASTLATTYSSGAFYERKIVTTDLRQGCTDDHTGTSVSAPMVAGVIALALEANPVLNWRDVQHLLVKTSRSVHLRAPDWKTNGAGRKVSHLYGFGLVDADAMVVEAKKWRTVPPQHVC--IGASDRRPRFIRAVQLIRTTTQTNACVDNAGHYVAYLEHVVVRVTISHPRRGDLQIYLISPSGTKSQLLAKRTFDSSNEGFKNWEFMTVHCWGEKAEGEWTLEIHDSSSQLRNPEIQGKLKEWTLIFYGTSEHPYNHIGTQHSR 606

[Close]

BLAST of Furin-1 vs. Ensembl Xenopus
Match: gdap1l1 (ganglioside induced differentiation associated protein 1-like 1 [Source:Xenbase;Acc:XB-GENE-950543])

HSP 1 Score: 593.964 bits (1530), Expect = 0.000e+0
Identity = 299/587 (50.94%), Postives = 399/587 (67.97%), Query Frame = 1

Query:  175 RGHYTDTWAVQINGTVDDARILAATYGFVFLNEI--MPSIYSFKHRRVSKRSIYPSNYYQSNLSDDPRVIWLEQQFAKVRVKRHI--------VNDPKWYKMWYLNKMNK----ENSMNIISAWKKGYRGQNVVVSILDDGIEKDHPDLKENYDPNASYDIISNDNNPEPRYISSNNTKIKDNHHGTRCAGQVAATANNRICGVGVAYKANIGGIRMLDGEVSDSVESHSLRLFYQHIDIYSASWGPEDDGKTVDGPGELAKIAFEDGILKGRNGLGSIFVWASGNGGKNHDNCNCDGYTNSIFTLGVNAVSEIGDAPWYAEKCSSTLAVTYSSGSMDERAIITTDVNHECTEQHSGTSASAPFAAGICALALSANRFLTWRDMQHLVVITARKANLRAVDWSTNAAGKEYSHSFGFGLMDAGAMVDLALNWTTVPEQHICHYVAPMQGGPISLKPYANEVLSITTDACSDNSKKRVRYLEHVQAKISLRSTKRGEVELWLISPSRSTSKLLTKRRNDVASAGFHHWPFMSVHFWGEEAPGTWKLTIYSYDAEV-------TLINWSLILYGTDTLPSHRQNSTHTK 1872
            R  +++ WAV+I G  + A  LAA YG++ L +I  + + Y F H R  KRS Y S    S L   P+V W++QQ  K RVKRH+         NDP W  MWYL+  +K     + MN++SAW++GY G+NVVVSILDDG+EK+HPDL +NYDP+AS+D+  +D +P PRY +SN     +N HGTRCAG+VAA+ANN  C VG+AY A IGGIRMLDG+V+D VE+ SL +   +IDIYS+SWGP+DDGKTVDGPG LA+ AFEDGI KGR GLGSIFVWASGNGG+  D C+CDGYTNSI+T+ +++ +E G  PWY E+C+STLA TYSSG+  ER I+TTD+   CT+ H+GTS SAP  AG+ ALAL AN  L WRD+QHL+V T+R  +LRA DW TN AG++ SH +GFGL+DA AMV  A  W TVP QH+C  +      P  ++       +  T+AC DN+   V YLEHV  ++++   +RG+++++LISPS + S+LL KR  D ++ GF +W FM+VH WGE+A G W L I+   +++        L  W+LI YGT   P +   + H++
Sbjct:   22 RTVFSNHWAVRIPGGPEVAAELAAQYGYLSLGQIGNLENYYHFYHSRTIKRSTYASRGTHSFLRMHPKVEWMQQQEVKKRVKRHVRTDPNLVNFNDPIWPNMWYLHCSDKSSRCRSEMNVMSAWQRGYTGKNVVVSILDDGVEKNHPDLIQNYDPHASHDVNGDDQDPSPRYDASN-----ENKHGTRCAGEVAASANNSHCIVGIAYNARIGGIRMLDGDVTDVVEAKSLGVRPDYIDIYSSSWGPDDDGKTVDGPGPLARKAFEDGIKKGRKGLGSIFVWASGNGGREGDYCSCDGYTNSIYTISISSTTENGYKPWYLEECASTLATTYSSGAFYERKIVTTDLRQGCTDDHTGTSVSAPMVAGVIALALEANPVLNWRDVQHLLVKTSRSVHLRAPDWKTNGAGRKVSHLYGFGLVDADAMVVEAKKWRTVPPQHVC--IGASDRRPRFIRAVQLIRTTTQTNACVDNAGHYVAYLEHVVVRVTISHPRRGDLQIYLISPSGTKSQLLAKRTFDSSNEGFKNWEFMTVHCWGEKAEGEWTLEIHDSSSQLRNPEIQGKLKEWTLIFYGTSEHPYNHIGTQHSR 601

[Close]

BLAST of Furin-1 vs. Ensembl Mouse
Match: Pcsk6 (proprotein convertase subtilisin/kexin type 6 [Source:MGI Symbol;Acc:MGI:102897])

HSP 1 Score: 591.652 bits (1524), Expect = 0.000e+0
Identity = 309/592 (52.20%), Postives = 397/592 (67.06%), Query Frame = 1

Query:  184 YTDTWAVQINGTVDDARILAATYGFVFLNEI--MPSIYSFKHRRVSKRSIYPSNYYQSNLSDDPRVIWLEQQFAKVRVKRHI------VNDPKWYKMWYLNKMNK----ENSMNIISAWKKGYRGQNVVVSILDDGIEKDHPDLKENYDPNASYDIISNDNNPEPRYISSNNTKIKDNHHGTRCAGQVAATANNRICGVGVAYKANIGGIRMLDGEVSDSVESHSLRLFYQHIDIYSASWGPEDDGKTVDGPGELAKIAFEDGILKGRNGLGSIFVWASGNGGKNHDNCNCDGYTNSIFTLGVNAVSEIGDAPWYAEKCSSTLAVTYSSGSMDERAIITTDVNHECTEQHSGTSASAPFAAGICALALSANRFLTWRDMQHLVVITARKANLRAVDWSTNAAGKEYSHSFGFGLMDAGAMVDLALNWTTVPEQHICHYVAPMQGGPISLKPYANEVLSITTDACSDNSKKRVRYLEHVQAKISLRSTKRGEVELWLISPSRSTSKLLTKRRNDVASAGFHHWPFMSVHFWGEEAPGTWKLTIYSYDAEV-------TLINWSLILYGTDTLPSHRQNSTHTKSQKRPPKNVP 1902
            YT+ WAVQ+ G    A  +AA +G++ L +I  +   Y F H +  KRS   S    + L  DP+V WL+QQ  K RVKR         NDP W  MWY++  +K     + MN+ +AWK+GY G+NVVV+ILDDGIE++HPDL  NYD  ASYD+  ND +P PRY +SN     +N HGTRCAG+VAA+ANN  C VG+AY A IGGIRMLDG+V+D VE+ SL +   +IDIYSASWGP+DDGKTVDGPG LAK AFE GI KGR GLGSIFVWASGNGG+  D+C+CDGYTNSI+T+ V++ +E G  PWY E+C+STLA TYSSG+  ER I+TTD+   CT+ H+GTS SAP  AGI ALAL AN  LTWRD+QHL+V T+R A+L+A DW  N AG + SH +GFGL+DA A+V  A  WT VP QH+C  VA     P S+        +  T+AC+D+S +RV YLEHV  +IS+   +RG++++ LISPS + S+LL KR  D ++ GF +W FM+VH WGE+A G W L +    ++V        L  WSLILYGT   P +R  S+H    +    +VP
Sbjct:   62 YTNHWAVQVLGGPGAADRVAAAHGYLNLGQIGNLDDYYHFYHSKTFKRSTLSSRGPHTFLRMDPQVKWLQQQEVKRRVKRQARSDSLYFNDPIWSNMWYMHCTDKNSRCRSEMNVQAAWKRGYTGKNVVVTILDDGIERNHPDLAPNYDSYASYDVNGNDYDPSPRYDASN-----ENKHGTRCAGEVAASANNSYCIVGIAYNAKIGGIRMLDGDVTDVVEAKSLGIRPNYIDIYSASWGPDDDGKTVDGPGRLAKQAFEYGIKKGRQGLGSIFVWASGNGGREGDHCSCDGYTNSIYTISVSSTTENGHKPWYLEECASTLATTYSSGAFYERKIVTTDLRQRCTDGHTGTSVSAPMVAGIIALALEANNQLTWRDVQHLLVKTSRPAHLKASDWKVNGAGHKVSHLYGFGLVDAEALVLEARKWTAVPSQHVC--VATADKRPRSIPIVQVLRTTALTNACADHSDQRVVYLEHVVVRISISHPRRGDLQIHLISPSGTKSQLLAKRLLDFSNEGFTNWEFMTVHCWGEKAEGEWTLEVQDIPSQVRNPEKQGKLKEWSLILYGTAEHP-YRTFSSHQSRSRMLELSVP 645

[Close]

BLAST of Furin-1 vs. Ensembl Mouse
Match: Pcsk6 (proprotein convertase subtilisin/kexin type 6 [Source:MGI Symbol;Acc:MGI:102897])

HSP 1 Score: 591.267 bits (1523), Expect = 0.000e+0
Identity = 309/592 (52.20%), Postives = 397/592 (67.06%), Query Frame = 1

Query:  184 YTDTWAVQINGTVDDARILAATYGFVFLNEI--MPSIYSFKHRRVSKRSIYPSNYYQSNLSDDPRVIWLEQQFAKVRVKRHI------VNDPKWYKMWYLNKMNK----ENSMNIISAWKKGYRGQNVVVSILDDGIEKDHPDLKENYDPNASYDIISNDNNPEPRYISSNNTKIKDNHHGTRCAGQVAATANNRICGVGVAYKANIGGIRMLDGEVSDSVESHSLRLFYQHIDIYSASWGPEDDGKTVDGPGELAKIAFEDGILKGRNGLGSIFVWASGNGGKNHDNCNCDGYTNSIFTLGVNAVSEIGDAPWYAEKCSSTLAVTYSSGSMDERAIITTDVNHECTEQHSGTSASAPFAAGICALALSANRFLTWRDMQHLVVITARKANLRAVDWSTNAAGKEYSHSFGFGLMDAGAMVDLALNWTTVPEQHICHYVAPMQGGPISLKPYANEVLSITTDACSDNSKKRVRYLEHVQAKISLRSTKRGEVELWLISPSRSTSKLLTKRRNDVASAGFHHWPFMSVHFWGEEAPGTWKLTIYSYDAEV-------TLINWSLILYGTDTLPSHRQNSTHTKSQKRPPKNVP 1902
            YT+ WAVQ+ G    A  +AA +G++ L +I  +   Y F H +  KRS   S    + L  DP+V WL+QQ  K RVKR         NDP W  MWY++  +K     + MN+ +AWK+GY G+NVVV+ILDDGIE++HPDL  NYD  ASYD+  ND +P PRY +SN     +N HGTRCAG+VAA+ANN  C VG+AY A IGGIRMLDG+V+D VE+ SL +   +IDIYSASWGP+DDGKTVDGPG LAK AFE GI KGR GLGSIFVWASGNGG+  D+C+CDGYTNSI+T+ V++ +E G  PWY E+C+STLA TYSSG+  ER I+TTD+   CT+ H+GTS SAP  AGI ALAL AN  LTWRD+QHL+V T+R A+L+A DW  N AG + SH +GFGL+DA A+V  A  WT VP QH+C  VA     P S+        +  T+AC+D+S +RV YLEHV  +IS+   +RG++++ LISPS + S+LL KR  D ++ GF +W FM+VH WGE+A G W L +    ++V        L  WSLILYGT   P +R  S+H    +    +VP
Sbjct:   62 YTNHWAVQVLGGPGAADRVAAAHGYLNLGQIGNLDDYYHFYHSKTFKRSTLSSRGPHTFLRMDPQVKWLQQQEVKRRVKRQARSDSLYFNDPIWSNMWYMHCTDKNSRCRSEMNVQAAWKRGYTGKNVVVTILDDGIERNHPDLAPNYDSYASYDVNGNDYDPSPRYDASN-----ENKHGTRCAGEVAASANNSYCIVGIAYNAKIGGIRMLDGDVTDVVEAKSLGIRPNYIDIYSASWGPDDDGKTVDGPGRLAKQAFEYGIKKGRQGLGSIFVWASGNGGREGDHCSCDGYTNSIYTISVSSTTENGHKPWYLEECASTLATTYSSGAFYERKIVTTDLRQRCTDGHTGTSVSAPMVAGIIALALEANNQLTWRDVQHLLVKTSRPAHLKASDWKVNGAGHKVSHLYGFGLVDAEALVLEARKWTAVPSQHVC--VATADKRPRSIPIVQVLRTTALTNACADHSDQRVVYLEHVVVRISISHPRRGDLQIHLISPSGTKSQLLAKRLLDFSNEGFTNWEFMTVHCWGEKAEGEWTLEVQDIPSQVRNPEKQGKLKEWSLILYGTAEHP-YRTFSSHQSRSRMLELSVP 645

[Close]

BLAST of Furin-1 vs. Ensembl Mouse
Match: Furin (furin (paired basic amino acid cleaving enzyme) [Source:MGI Symbol;Acc:MGI:97513])

HSP 1 Score: 580.096 bits (1494), Expect = 0.000e+0
Identity = 298/576 (51.74%), Postives = 386/576 (67.01%), Query Frame = 1

Query:  184 YTDTWAVQINGTVDDARILAATYGFVFLNEIMPSIYSFKHRRVSKRSIYPSNYYQSNLSDDPRVIWLEQQFAKVRVKRHIVN---DPKWYKMWYLNKMNKENSMNIISAWKKGYRGQNVVVSILDDGIEKDHPDLKENYDPNASYDIISNDNNPEPRYISSNNTKIKDNHHGTRCAGQVAATANNRICGVGVAYKANIGGIRMLDGEVSDSVESHSLRLFYQHIDIYSASWGPEDDGKTVDGPGELAKIAFEDGILKGRNGLGSIFVWASGNGGKNHDNCNCDGYTNSIFTLGVNAVSEIGDAPWYAEKCSSTLAVTYSSGSMDERAIITTDVNHECTEQHSGTSASAPFAAGICALALSANRFLTWRDMQHLVVITARKANLRAVDWSTNAAGKEYSHSFGFGLMDAGAMVDLALNWTTVPEQHICHYVAPMQGGPISLKPYANEVLSITTDACSDNSKKRVRYLEHVQAKISLRSTKRGEVELWLISPSRSTSKLLTKRRNDVASAGFHHWPFMSVHFWGEEAPGTWKLTIYSYDAE---VTLINWSLILYGT-----DTLPSHRQNSTHTKSQ 1878
            +T+TWAV I G    A  +A  +GF  L +I    Y F HR V+KRS+ P     S L  +P+V WLEQQ AK R KR +     DPK+ + WYL+ + + + +N+  AW +G+ G  +VVSILDDGIEK+HPDL  NYDP AS+D+   D +P+PRY     T++ DN HGTRCAG+VAA ANN +CGVGVAY A IGG+RMLDGEV+D+VE+ SL L   HI IYSASWGPEDDGKTVDGP  LA+ AF  G+ +GR GLGSIFVWASGNGG+ HD+CNCDGYTNSI+TL +++ ++ G+ PWY+E CSSTLA TYSSG+ +E+ I+TTD+  +CTE H+GTSASAP AAGI AL L AN+ LTWRDMQHLVV T++ A+L A DW+TN  G++ SHS+G+GL+DAGAMV LA NWTTV  Q  C     ++   I  +    + ++    AC        R LEHVQA+++L   +RG++ + LISP  + S LL  R +D ++ GF+ W FM+ H W E+  G W L I +        TL  ++L+LYGT      T P      T T SQ
Sbjct:   30 FTNTWAVHIPGGPAVADRVAQKHGFHNLGQIFGDYYHFWHRAVTKRSLSPHRPRHSRLQREPQVKWLEQQVAKRRAKRDVYQEPTDPKFPQQWYLSGVTQRD-LNVKEAWAQGFTGHGIVVSILDDGIEKNHPDLAGNYDPGASFDVNDQDPDPQPRY-----TQMNDNRHGTRCAGEVAAVANNGVCGVGVAYNARIGGVRMLDGEVTDAVEARSLGLNPNHIHIYSASWGPEDDGKTVDGPARLAEEAFFRGVSQGRGGLGSIFVWASGNGGREHDSCNCDGYTNSIYTLSISSATQFGNVPWYSEACSSTLATTYSSGNQNEKQIVTTDLRQKCTESHTGTSASAPLAAGIIALTLEANKNLTWRDMQHLVVQTSKPAHLNADDWATNGVGRKVSHSYGYGLLDAGAMVALAQNWTTVAPQRKCIVEILVEPKDIGKRLEVRKAVT----ACLGEPNHITR-LEHVQARLTLSYNRRGDLAIHLISPMGTRSTLLAARPHDYSADGFNDWAFMTTHSWDEDPAGEWVLEIENTSEANNYGTLTKFTLVLYGTAPEGLSTPPESSGCKTLTSSQ 594

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Query:  184 YTDTWAVQINGTVDDARILAATYGFVFLNEIMPSIYSFKHRRVSKRSIYPSNYYQSNLSDDPRVIWLEQQFAKVRVKRHIVN---DPKWYKMWYLNKMNKENSMNIISAWKKGYRGQNVVVSILDDGIEKDHPDLKENYDPNASYDIISNDNNPEPRYISSNNTKIKDNHHGTRCAGQVAATANNRICGVGVAYKANIGGIRMLDGEVSDSVESHSLRLFYQHIDIYSASWGPEDDGKTVDGPGELAKIAFEDGILKGRNGLGSIFVWASGNGGKNHDNCNCDGYTNSIFTLGVNAVSEIGDAPWYAEKCSSTLAVTYSSGSMDERAIITTDVNHECTEQHSGTSASAPFAAGICALALSANRFLTWRDMQHLVVITARKANLRAVDWSTNAAGKEYSHSFGFGLMDAGAMVDLALNWTTVPEQHICHYVAPMQGGPISLKPYANEVLSITTDACSDNSKKRVRYLEHVQAKISLRSTKRGEVELWLISPSRSTSKLLTKRRNDVASAGFHHWPFMSVHFWGEEAPGTWKLTIYSYDAE---VTLINWSLILYGT-----DTLPSHRQNSTHTKSQ 1878
            +T+TWAV I G    A  +A  +GF  L +I    Y F HR V+KRS+ P     S L  +P+V WLEQQ AK R KR +     DPK+ + WYL+ + + + +N+  AW +G+ G  +VVSILDDGIEK+HPDL  NYDP AS+D+   D +P+PRY     T++ DN HGTRCAG+VAA ANN +CGVGVAY A IGG+RMLDGEV+D+VE+ SL L   HI IYSASWGPEDDGKTVDGP  LA+ AF  G+ +GR GLGSIFVWASGNGG+ HD+CNCDGYTNSI+TL +++ ++ G+ PWY+E CSSTLA TYSSG+ +E+ I+TTD+  +CTE H+GTSASAP AAGI AL L AN+ LTWRDMQHLVV T++ A+L A DW+TN  G++ SHS+G+GL+DAGAMV LA NWTTV  Q  C     ++   I  +    + ++    AC        R LEHVQA+++L   +RG++ + LISP  + S LL  R +D ++ GF+ W FM+ H W E+  G W L I +        TL  ++L+LYGT      T P      T T SQ
Sbjct:   30 FTNTWAVHIPGGPAVADRVAQKHGFHNLGQIFGDYYHFWHRAVTKRSLSPHRPRHSRLQREPQVKWLEQQVAKRRAKRDVYQEPTDPKFPQQWYLSGVTQRD-LNVKEAWAQGFTGHGIVVSILDDGIEKNHPDLAGNYDPGASFDVNDQDPDPQPRY-----TQMNDNRHGTRCAGEVAAVANNGVCGVGVAYNARIGGVRMLDGEVTDAVEARSLGLNPNHIHIYSASWGPEDDGKTVDGPARLAEEAFFRGVSQGRGGLGSIFVWASGNGGREHDSCNCDGYTNSIYTLSISSATQFGNVPWYSEACSSTLATTYSSGNQNEKQIVTTDLRQKCTESHTGTSASAPLAAGIIALTLEANKNLTWRDMQHLVVQTSKPAHLNADDWATNGVGRKVSHSYGYGLLDAGAMVALAQNWTTVAPQRKCIVEILVEPKDIGKRLEVRKAVT----ACLGEPNHITR-LEHVQARLTLSYNRRGDLAIHLISPMGTRSTLLAARPHDYSADGFNDWAFMTTHSWDEDPAGEWVLEIENTSEANNYGTLTKFTLVLYGTAPEGLSTPPESSGCKTLTSSQ 594

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Query:  184 YTDTWAVQINGTVDDARILAATYGFVFLNEIMPSIYSFKHRRVSKRSIYPSNYYQSNLSDDPRVIWLEQQFAKVRVKRHIVN---DPKWYKMWYLNKMNKENSMNIISAWKKGYRGQNVVVSILDDGIEKDHPDLKENYDPNASYDIISNDNNPEPRYISSNNTKIKDNHHGTRCAGQVAATANNRICGVGVAYKANIGGIRMLDGEVSDSVESHSLRLFYQHIDIYSASWGPEDDGKTVDGPGELAKIAFEDGILKGRNGLGSIFVWASGNGGKNHDNCNCDGYTNSIFTLGVNAVSEIGDAPWYAEKCSSTLAVTYSSGSMDERAIITTDVNHECTEQHSGTSASAPFAAGICALALSANRFLTWRDMQHLVVITARKANLRAVDWSTNAAGKEYSHSFGFGLMDAGAMVDLALNWTTVPEQHICHYVAPMQGGPISLKPYANEVLSITTDACSDNSKKRVRYLEHVQAKISLRSTKRGEVELWLISPSRSTSKLLTKRRNDVASAGFHHWPFMSVHFWGEEAPGTWKLTIYSYDAE---VTLINWSLILYGT-----DTLPSHRQNSTHTKSQ 1878
            +T+TWAV I G    A  +A  +GF  L +I    Y F HR V+KRS+ P     S L  +P+V WLEQQ AK R KR +     DPK+ + WYL+ + + + +N+  AW +G+ G  +VVSILDDGIEK+HPDL  NYDP AS+D+   D +P+PRY     T++ DN HGTRCAG+VAA ANN +CGVGVAY A IGG+RMLDGEV+D+VE+ SL L   HI IYSASWGPEDDGKTVDGP  LA+ AF  G+ +GR GLGSIFVWASGNGG+ HD+CNCDGYTNSI+TL +++ ++ G+ PWY+E CSSTLA TYSSG+ +E+ I+TTD+  +CTE H+GTSASAP AAGI AL L AN+ LTWRDMQHLVV T++ A+L A DW+TN  G++ SHS+G+GL+DAGAMV LA NWTTV  Q  C     ++   I  +    + ++    AC        R LEHVQA+++L   +RG++ + LISP  + S LL  R +D ++ GF+ W FM+ H W E+  G W L I +        TL  ++L+LYGT      T P      T T SQ
Sbjct:   30 FTNTWAVHIPGGPAVADRVAQKHGFHNLGQIFGDYYHFWHRAVTKRSLSPHRPRHSRLQREPQVKWLEQQVAKRRAKRDVYQEPTDPKFPQQWYLSGVTQRD-LNVKEAWAQGFTGHGIVVSILDDGIEKNHPDLAGNYDPGASFDVNDQDPDPQPRY-----TQMNDNRHGTRCAGEVAAVANNGVCGVGVAYNARIGGVRMLDGEVTDAVEARSLGLNPNHIHIYSASWGPEDDGKTVDGPARLAEEAFFRGVSQGRGGLGSIFVWASGNGGREHDSCNCDGYTNSIYTLSISSATQFGNVPWYSEACSSTLATTYSSGNQNEKQIVTTDLRQKCTESHTGTSASAPLAAGIIALTLEANKNLTWRDMQHLVVQTSKPAHLNADDWATNGVGRKVSHSYGYGLLDAGAMVALAQNWTTVAPQRKCIVEILVEPKDIGKRLEVRKAVT----ACLGEPNHITR-LEHVQARLTLSYNRRGDLAIHLISPMGTRSTLLAARPHDYSADGFNDWAFMTTHSWDEDPAGEWVLEIENTSEANNYGTLTKFTLVLYGTAPEGLSTPPESSGCKTLTSSQ 594

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BLAST of Furin-1 vs. UniProt/SwissProt
Match: sp|P26016|FUR11_DROME (Furin-like protease 1, isoforms 1/1-X/2 OS=Drosophila melanogaster OX=7227 GN=Fur1 PE=2 SV=2)

HSP 1 Score: 607.06 bits (1564), Expect = 0.000e+0
Identity = 310/575 (53.91%), Postives = 392/575 (68.17%), Query Frame = 1

Query:  178 GHYTDTWAVQI-NGTVDDARILAATYGFVFLNEIMPSIYSFKHRRVSKRSIYPSNYYQSNLSDDPRVIWLEQQFAKVRVKRHIV--------------------NDPKWYKMWYLNKMNKENSMNIISAWKKGYRGQNVVVSILDDGIEKDHPDLKENYDPNASYDIISNDNNPEPRYISSNNTKIKDNHHGTRCAGQVAATANNRICGVGVAYKANIGGIRMLDGEVSDSVESHSLRLFYQHIDIYSASWGPEDDGKTVDGPGELAKIAFEDGILKGRNGLGSIFVWASGNGGKNHDNCNCDGYTNSIFTLGVNAVSEIGDAPWYAEKCSSTLAVTYSSGSMDERAIITTDVNHECTEQHSGTSASAPFAAGICALALSANRFLTWRDMQHLVVITARKANLRAVDWSTNAAGKEYSHSFGFGLMDAGAMVDLALNWTTVPEQHICHYVAPMQGGPISLKPYANEVLSITTDACSDNSKKRVRYLEHVQAKISLRSTKRGEVELWLISPSRSTSKLLTKRRNDVASAGFHHWPFMSVHFWGEEAPGTWKLTIYS---YDAEVTLINWSLILYGT 1830
            GHYT TWAV I NG    A  +A  +GFV L +I    Y F H +VSKRS+ P+ ++Q+ L DD RV W +QQ AK R KR  +                    ND KW +MWYLN+    + MN+I AWK G  G+ VVV+ILDDG+E DHPD+++NYDP ASYD+ S+D++P P Y  +++     N HGTRCAG+VAATANN  C VG+AY A++GG+RMLDG+V+D+VE+ SL L  QHIDIYSASWGP+DDGKTVDGPGELA  AF +G  KGR G GSIF+WASGNGG+  DNCNCDGYTNSI+TL +++ +E G  PWY+EKCSSTLA TYSSG   E+ ++TTD++H CT  H+GTSASAP AAGI AL L +N+ LTWRD+QH+VV TA+ ANL+   WS N  G+  SHSFG+GLMDA  MV +A NW  VPEQ  C   AP     I   P  +  L +T + C     + V YLEHVQAKI+L S +RG+++L+L SP+ ++  LLT R +D + +GF+ WPFMSVH WGE   G W+L I++   Y     L  WSLI YGT
Sbjct:  229 GHYTHTWAVHIPNGDNGMADAVAKDHGFVNLGKIFDDHYHFAHHKVSKRSLSPATHHQTRLDDDDRVHWAKQQRAKSRSKRDFIRMRPSRTSSRAMSMVDAMSFNDSKWPQMWYLNRGGGLD-MNVIPAWKMGITGKGVVVTILDDGLESDHPDIQDNYDPKASYDVNSHDDDPMPHYDMTDS-----NRHGTRCAGEVAATANNSFCAVGIAYGASVGGVRMLDGDVTDAVEARSLSLNPQHIDIYSASWGPDDDGKTVDGPGELASRAFIEGTTKGRGGKGSIFIWASGNGGREQDNCNCDGYTNSIWTLSISSATEEGHVPWYSEKCSSTLATTYSSGGQGEKQVVTTDLHHSCTVSHTGTSASAPLAAGIAALVLQSNQNLTWRDLQHIVVRTAKPANLKDPSWSRNGVGRRVSHSFGYGLMDAAEMVRVARNWKAVPEQQRCEINAPHVDKVI--PPRTHITLQLTVNHC-----RSVNYLEHVQAKITLTSQRRGDIQLFLRSPANTSVTLLTPRIHDNSRSGFNQWPFMSVHTWGESPQGNWQLEIHNEGRYMGHALLREWSLIFYGT 790

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BLAST of Furin-1 vs. UniProt/SwissProt
Match: sp|P30430|FUR1C_DROME (Furin-like protease 1, isoform 1-CRR OS=Drosophila melanogaster OX=7227 GN=Fur1 PE=2 SV=2)

HSP 1 Score: 603.208 bits (1554), Expect = 0.000e+0
Identity = 310/577 (53.73%), Postives = 396/577 (68.63%), Query Frame = 1

Query:  178 GHYTDTWAVQI-NGTVDDARILAATYGFVFLNEIMPSIYSFKHRRVSKRSIYPSNYYQSNLSDDPRVIWLEQQFAKVRVKRHIV--------------------NDPKWYKMWYLNKMNKENSMNIISAWKKGYRGQNVVVSILDDGIEKDHPDLKENYDPNASYDIISNDNNPEPRYISSNNTKIKDNHHGTRCAGQVAATANNRICGVGVAYKANIGGIRMLDGEVSDSVESHSLRLFYQHIDIYSASWGPEDDGKTVDGPGELAKIAFEDGILKGRNGLGSIFVWASGNGGKNHDNCNCDGYTNSIFTLGVNAVSEIGDAPWYAEKCSSTLAVTYSSGSMDERAIITTDVNHECTEQHSGTSASAPFAAGICALALSANRFLTWRDMQHLVVITARKANLRAVDWSTNAAGKEYSHSFGFGLMDAGAMVDLALNWTTVPEQHICHYVAPMQGGPISLKPYANEVLSITTDACSDNSKKRVRYLEHVQAKISLRSTKRGEVELWLISPSRSTSKLLTKRRNDVASAGFHHWPFMSVHFWGEEAPGTWKLTIYS---YDAEVTLINWSLILYGTDT 1836
            GHYT TWAV I NG    A  +A  +GFV L +I    Y F H +VSKRS+ P+ ++Q+ L DD RV W +QQ AK R KR  +                    ND KW +MWYLN+    + MN+I AWK G  G+ VVV+ILDDG+E DHPD+++NYDP ASYD+ S+D++P P Y  +++     N HGTRCAG+VAATANN  C VG+AY A++GG+RMLDG+V+D+VE+ SL L  QHIDIYSASWGP+DDGKTVDGPGELA  AF +G  KGR G GSIF+WASGNGG+  DNCNCDGYTNSI+TL +++ +E G  PWY+EKCSSTLA TYSSG   E+ ++TTD++H CT  H+GTSASAP AAGI AL L +N+ LTWRD+QH+VV TA+ ANL+   WS N  G+  SHSFG+GLMDA  MV +A NW  VPEQ  C   AP     I   P  +  L +T + C     + V YLEHVQAKI+L S +RG+++L+L SP+ ++  LLT R +D + +GF+ WPFMSVH WGE   G W+L I++   Y A++T   W +I YGT+T
Sbjct:  229 GHYTHTWAVHIPNGDNGMADAVAKDHGFVNLGKIFDDHYHFAHHKVSKRSLSPATHHQTRLDDDDRVHWAKQQRAKSRSKRDFIRMRPSRTSSRAMSMVDAMSFNDSKWPQMWYLNRGGGLD-MNVIPAWKMGITGKGVVVTILDDGLESDHPDIQDNYDPKASYDVNSHDDDPMPHYDMTDS-----NRHGTRCAGEVAATANNSFCAVGIAYGASVGGVRMLDGDVTDAVEARSLSLNPQHIDIYSASWGPDDDGKTVDGPGELASRAFIEGTTKGRGGKGSIFIWASGNGGREQDNCNCDGYTNSIWTLSISSATEEGHVPWYSEKCSSTLATTYSSGGQGEKQVVTTDLHHSCTVSHTGTSASAPLAAGIAALVLQSNQNLTWRDLQHIVVRTAKPANLKDPSWSRNGVGRRVSHSFGYGLMDAAEMVRVARNWKAVPEQQRCEINAPHVDKVI--PPRTHITLQLTVNHC-----RSVNYLEHVQAKITLTSQRRGDIQLFLRSPANTSVTLLTPRIHDNSRSGFNQWPFMSVHTWGESPQGNWQLEIHNEGRYMAQIT--QWDMIFYGTET 790

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BLAST of Furin-1 vs. UniProt/SwissProt
Match: sp|Q63415|PCSK6_RAT (Proprotein convertase subtilisin/kexin type 6 OS=Rattus norvegicus OX=10116 GN=Pcsk6 PE=1 SV=1)

HSP 1 Score: 590.112 bits (1520), Expect = 0.000e+0
Identity = 309/592 (52.20%), Postives = 397/592 (67.06%), Query Frame = 1

Query:  184 YTDTWAVQINGTVDDARILAATYGFVFLNEI--MPSIYSFKHRRVSKRSIYPSNYYQSNLSDDPRVIWLEQQFAKVRVKRHI------VNDPKWYKMWYLNKMNK----ENSMNIISAWKKGYRGQNVVVSILDDGIEKDHPDLKENYDPNASYDIISNDNNPEPRYISSNNTKIKDNHHGTRCAGQVAATANNRICGVGVAYKANIGGIRMLDGEVSDSVESHSLRLFYQHIDIYSASWGPEDDGKTVDGPGELAKIAFEDGILKGRNGLGSIFVWASGNGGKNHDNCNCDGYTNSIFTLGVNAVSEIGDAPWYAEKCSSTLAVTYSSGSMDERAIITTDVNHECTEQHSGTSASAPFAAGICALALSANRFLTWRDMQHLVVITARKANLRAVDWSTNAAGKEYSHSFGFGLMDAGAMVDLALNWTTVPEQHICHYVAPMQGGPISLKPYANEVLSITTDACSDNSKKRVRYLEHVQAKISLRSTKRGEVELWLISPSRSTSKLLTKRRNDVASAGFHHWPFMSVHFWGEEAPGTWKLTIYSYDAEV-------TLINWSLILYGTDTLPSHRQNSTHTKSQKRPPKNVP 1902
            YT+ WAVQ+ G    A  +AA +G++ L +I  +   Y F H +  KRS   S    + L  DP+V WL+QQ  K RVKR         NDP W  MWY++  +K     + MN+ +AWK+GY G+NVVV+ILDDGIE++HPDL  NYD  ASYD+  ND +P PRY +SN     +N HGTRCAG+VAA+ANN  C VG+AY A IGGIRMLDG+V+D VE+ SL +   +IDIYSASWGP+DDGKTVDGPG LAK AFE GI KGR GLGSIFVWASGNGG+  D+C+CDGYTNSI+T+ V++ +E G  PWY E+C+STLA TYSSG+  ER I+TTD+   CT+ H+GTS SAP  AGI ALAL AN  LTWRD+QHL+V T+R A+L+A DW  N AG + SH +GFGL+DA A+V  A  WT VP QH+C  VA     P S+        +  T+AC+D+S +RV YLEHV  +IS+   +RG++++ LISPS + S+LL KR  D ++ GF +W FM+VH WGE+A G W L +    ++V        L  WSLILYGT   P +R  S+H    +    +VP
Sbjct:   53 YTNHWAVQVLGGPGAADRVAAAHGYLNLGQIGNLDDYYHFYHSKTFKRSTLSSRGPHTFLRMDPQVKWLQQQEVKRRVKRQARSDSLYFNDPIWSNMWYMHCADKNSRCRSEMNVQAAWKRGYTGKNVVVTILDDGIERNHPDLAPNYDSYASYDVNGNDYDPSPRYDASN-----ENKHGTRCAGEVAASANNSYCIVGIAYNAKIGGIRMLDGDVTDVVEAKSLGIRPNYIDIYSASWGPDDDGKTVDGPGRLAKQAFEYGIKKGRQGLGSIFVWASGNGGREGDHCSCDGYTNSIYTISVSSTTENGHKPWYLEECASTLATTYSSGAFYERKIVTTDLRQRCTDGHTGTSVSAPMVAGIIALALEANNQLTWRDVQHLLVKTSRPAHLKASDWKVNGAGHKVSHLYGFGLVDAEALVLEARKWTAVPSQHMC--VATADKRPRSIPVVQVLRTTALTNACADHSDQRVVYLEHVVVRISISHPRRGDLQIHLISPSGTKSQLLAKRLLDFSNEGFTNWEFMTVHCWGEKAEGEWTLEVQDIPSQVRNPEKQGKLKEWSLILYGTAEHP-YRTFSSHQSRSRMLELSVP 636

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BLAST of Furin-1 vs. UniProt/SwissProt
Match: sp|P29122|PCSK6_HUMAN (Proprotein convertase subtilisin/kexin type 6 OS=Homo sapiens OX=9606 GN=PCSK6 PE=1 SV=1)

HSP 1 Score: 590.112 bits (1520), Expect = 0.000e+0
Identity = 306/589 (51.95%), Postives = 397/589 (67.40%), Query Frame = 1

Query:  175 RGHYTDTWAVQINGTVDDARILAATYGFVFLNEI--MPSIYSFKHRRVSKRSIYPSNYYQSNLSDDPRVIWLEQQFAKVRVKRHI--------VNDPKWYKMWYLNKMNK----ENSMNIISAWKKGYRGQNVVVSILDDGIEKDHPDLKENYDPNASYDIISNDNNPEPRYISSNNTKIKDNHHGTRCAGQVAATANNRICGVGVAYKANIGGIRMLDGEVSDSVESHSLRLFYQHIDIYSASWGPEDDGKTVDGPGELAKIAFEDGILKGRNGLGSIFVWASGNGGKNHDNCNCDGYTNSIFTLGVNAVSEIGDAPWYAEKCSSTLAVTYSSGSMDERAIITTDVNHECTEQHSGTSASAPFAAGICALALSANRFLTWRDMQHLVVITARKANLRAVDWSTNAAGKEYSHSFGFGLMDAGAMVDLALNWTTVPEQHICHYVAPMQGGPISLKPYANEVLSITTDACSDNSKKRVRYLEHVQAKISLRSTKRGEVELWLISPSRSTSKLLTKRRNDVASAGFHHWPFMSVHFWGEEAPGTWKLTIYSYDAEV-------TLINWSLILYGTDTLPSHRQNSTHTKSQ 1878
            R  YT+ WAVQ+ G   +A  +AA +G++ L +I  +   Y F H +  KRS   S    + L  DP+V WL+QQ  K RVKR +         NDP W  MWYL+  +K     + MN+ +AWK+GY G+NVVV+ILDDGIE++HPDL  NYD  ASYD+  ND +P PRY +SN     +N HGTRCAG+VAA+ANN  C VG+AY A IGGIRMLDG+V+D VE+ SL +   +IDIYSASWGP+DDGKTVDGPG LAK AFE GI KGR GLGSIFVWASGNGG+  D C+CDGYTNSI+T+ V++ +E G  PWY E+C+STLA TYSSG+  ER I+TTD+   CT+ H+GTS SAP  AGI ALAL AN  LTWRD+QHL+V T+R A+L+A DW  N AG + SH +GFGL+DA A+V  A  WT VP QH+C  VA     P S+        +  T AC+++S +RV YLEHV  + S+   +RG+++++L+SPS + S+LL KR  D+++ GF +W FM+VH WGE+A G W L I    ++V        L  WSLILYGT   P H  ++  ++S+
Sbjct:   67 RPVYTNHWAVQVLGGPAEADRVAAAHGYLNLGQIGNLEDYYHFYHSKTFKRSTLSSRGPHTFLRMDPQVKWLQQQEVKRRVKRQVRSDPQALYFNDPIWSNMWYLHCGDKNSRCRSEMNVQAAWKRGYTGKNVVVTILDDGIERNHPDLAPNYDSYASYDVNGNDYDPSPRYDASN-----ENKHGTRCAGEVAASANNSYCIVGIAYNAKIGGIRMLDGDVTDVVEAKSLGIRPNYIDIYSASWGPDDDGKTVDGPGRLAKQAFEYGIKKGRQGLGSIFVWASGNGGREGDYCSCDGYTNSIYTISVSSATENGYKPWYLEECASTLATTYSSGAFYERKIVTTDLRQRCTDGHTGTSVSAPMVAGIIALALEANSQLTWRDVQHLLVKTSRPAHLKASDWKVNGAGHKVSHFYGFGLVDAEALVVEAKKWTAVPSQHMC--VAASDKRPRSIPLVQVLRTTALTSACAEHSDQRVVYLEHVVVRTSISHPRRGDLQIYLVSPSGTKSQLLAKRLLDLSNEGFTNWEFMTVHCWGEKAEGQWTLEIQDLPSQVRNPEKQGKLKEWSLILYGTAEHPYHTFSAHQSRSR 648

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BLAST of Furin-1 vs. UniProt/SwissProt
Match: sp|P09958|FURIN_HUMAN (Furin OS=Homo sapiens OX=9606 GN=FURIN PE=1 SV=2)

HSP 1 Score: 582.408 bits (1500), Expect = 0.000e+0
Identity = 303/597 (50.75%), Postives = 399/597 (66.83%), Query Frame = 1

Query:  121 VILFSSLFCFGAKSQSESRGHYTDTWAVQINGTVDDARILAATYGFVFLNEIMPSIYSFKHRRVSKRSIYPSNYYQSNLSDDPRVIWLEQQFAKVRVKRHIVN---DPKWYKMWYLNKMNKENSMNIISAWKKGYRGQNVVVSILDDGIEKDHPDLKENYDPNASYDIISNDNNPEPRYISSNNTKIKDNHHGTRCAGQVAATANNRICGVGVAYKANIGGIRMLDGEVSDSVESHSLRLFYQHIDIYSASWGPEDDGKTVDGPGELAKIAFEDGILKGRNGLGSIFVWASGNGGKNHDNCNCDGYTNSIFTLGVNAVSEIGDAPWYAEKCSSTLAVTYSSGSMDERAIITTDVNHECTEQHSGTSASAPFAAGICALALSANRFLTWRDMQHLVVITARKANLRAVDWSTNAAGKEYSHSFGFGLMDAGAMVDLALNWTTVPEQHICHYVAPMQGGPISLKPYANEVLSITTDACSDNSKKRVRYLEHVQAKISLRSTKRGEVELWLISPSRSTSKLLTKRRNDVASAGFHHWPFMSVHFWGEEAPGTWKLTIYSYDAE---VTLINWSLILYGT--DTLPSHRQNS---THTKSQ 1878
            V    +L    A +Q +    +T+TWAV+I G    A  +A  +GF+ L +I    Y F HR V+KRS+ P     S L  +P+V WLEQQ AK R KR +     DPK+ + WYL+ + + + +N+ +AW +GY G  +VVSILDDGIEK+HPDL  NYDP AS+D+   D +P+PRY     T++ DN HGTRCAG+VAA ANN +CGVGVAY A IGG+RMLDGEV+D+VE+ SL L   HI IYSASWGPEDDGKTVDGP  LA+ AF  G+ +GR GLGSIFVWASGNGG+ HD+CNCDGYTNSI+TL +++ ++ G+ PWY+E CSSTLA TYSSG+ +E+ I+TTD+  +CTE H+GTSASAP AAGI AL L AN+ LTWRDMQHLVV T++ A+L A DW+TN  G++ SHS+G+GL+DAGAMV LA NWTTV  Q  C  +  +   P  +        ++T  AC        R LEH QA+++L   +RG++ + L+SP  + S LL  R +D ++ GF+ W FM+ H W E+  G W L I +        TL  ++L+LYGT  + LP   ++S   T T SQ
Sbjct:   11 VAATGTLVLLAADAQGQKV--FTNTWAVRIPGGPAVANSVARKHGFLNLGQIFGDYYHFWHRGVTKRSLSPHRPRHSRLQREPQVQWLEQQVAKRRTKRDVYQEPTDPKFPQQWYLSGVTQRD-LNVKAAWAQGYTGHGIVVSILDDGIEKNHPDLAGNYDPGASFDVNDQDPDPQPRY-----TQMNDNRHGTRCAGEVAAVANNGVCGVGVAYNARIGGVRMLDGEVTDAVEARSLGLNPNHIHIYSASWGPEDDGKTVDGPARLAEEAFFRGVSQGRGGLGSIFVWASGNGGREHDSCNCDGYTNSIYTLSISSATQFGNVPWYSEACSSTLATTYSSGNQNEKQIVTTDLRQKCTESHTGTSASAPLAAGIIALTLEANKNLTWRDMQHLVVQTSKPAHLNANDWATNGVGRKVSHSYGYGLLDAGAMVALAQNWTTVAPQRKC--IIDILTEPKDIGKRLEVRKTVT--ACLGEPNHITR-LEHAQARLTLSYNRRGDLAIHLVSPMGTRSTLLAARPHDYSADGFNDWAFMTTHSWDEDPSGEWVLEIENTSEANNYGTLTKFTLVLYGTAPEGLPVPPESSGCKTLTSSQ 594

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BLAST of Furin-1 vs. TrEMBL
Match: A0A5K4FDH6 (Uncharacterized protein OS=Schistosoma mansoni OX=6183 PE=4 SV=1)

HSP 1 Score: 752.281 bits (1941), Expect = 0.000e+0
Identity = 364/629 (57.87%), Postives = 458/629 (72.81%), Query Frame = 1

Query:   94 YEYIVMKCFVILFSSLFCFGAKSQS------------------ESRGHYTDTWAVQINGTVDDARILAATYGFVFLNEIMPSIYSFKHRRVSKRSIYPSNYYQSNLSDDPRVIWLEQQFAKVRVKRHI---VNDPKWYKMWYLNKMNKEN-SMNIISAWKKGYRGQNVVVSILDDGIEKDHPDLKENYDPNASYDIISNDNNPEPRYISSNNTKIKDNHHGTRCAGQVAATANNRICGVGVAYKANIGGIRMLDGEVSDSVESHSLRLFYQHIDIYSASWGPEDDGKTVDGPGELAKIAFEDGILKGRNGLGSIFVWASGNGGKNHDNCNCDGYTNSIFTLGVNAVSEIGDAPWYAEKCSSTLAVTYSSGSMDERAIITTDVNHECTEQHSGTSASAPFAAGICALALSANRFLTWRDMQHLVVITARKANLRAVDWSTNAAGKEYSHSFGFGLMDAGAMVDLALNWTTVPEQHICHYVAPMQGGPISLKPYANEVLSITTDAC------SDNSKKRVRYLEHVQAKISLRSTKRGEVELWLISPSRSTSKLLTKRRNDVASAGFHHWPFMSVHFWGEEAPGTWKLTIYSYDAEVTLINWSLILYGTDTLPSHRQNSTHTKSQKRPPKN 1896
            Y+   + C +++   L C    +Q+                  + +  YT  WAV+I G    AR +A  YGF++L EI+P IY FKH R+SKRS+  +NYY   L++D +V+WLEQQ AKVRVKR +   V+DPKW +MWYLN+       MN+ S W +GY GQ+VVV+ILDDG+E DHPDLK+NYDP ASYD+ SND+NPEPRY++ +  K   N HGTRCAG+VAA ANN +CG+G+AY+A IGG+RMLDG+V+D++ES SL    QHID+YSASWGPEDDGKTVDGPG+LA++AF +GI  GR GLGSIFVWASGNGG +HDNCNCDGYTNSI+TLGV +VSE G  PWYAE CSSTLAVTYSSG   ER +ITTD+NH CT+ HSGTSASAP AAGICAL LSAN  LTWRD+Q+LVV TAR   L A DW  N  G+  SH+FG+GLMDA AMVDLALNWT VP Q +C   APM G PI+++  + E L++TTD C      + +   RV +LEHVQAK++L S +RGE+ELWL SP+ + S+LL+KR  D+  AGFH WPFMSVH+WGE A GTWKLT+ S +A V++ +WSLILYGT+T P    +S+H +  ++ P+N
Sbjct:   19 YKICSLVCIILVTVRLCCCTTNNQTIPKQNASTSPELSDLPHNKRKALYTPYWAVEIKGGEKAARAIAEKYGFLYLGEILPGIYHFKHNRISKRSLRQNNYYHDQLANDEQVVWLEQQVAKVRVKRDVHIPVSDPKWPQMWYLNRGGPGGLDMNVRSVWARGYAGQSVVVTILDDGLETDHPDLKDNYDPFASYDVNSNDDNPEPRYLTRD--KSNTNRHGTRCAGEVAAAANNSVCGLGIAYRARIGGVRMLDGDVTDAMESRSLSHQLQHIDVYSASWGPEDDGKTVDGPGKLAQMAFRNGIQMGRRGLGSIFVWASGNGGTSHDNCNCDGYTNSIYTLGVGSVSEHGSVPWYAELCSSTLAVTYSSGGRGERGVITTDLNHTCTDNHSGTSASAPLAAGICALTLSANPNLTWRDLQYLVVYTARPDGLYADDWHVNGVGRRVSHAFGYGLMDAAAMVDLALNWTNVPPQRVCEAQAPMTGSPITIRQMSKENLALTTDGCESAAALAGDLSHRVVHLEHVQAKVTLSSAQRGEIELWLTSPAGTISQLLSKRPKDIDVAGFHAWPFMSVHYWGELANGTWKLTVKSGNAVVSIHDWSLILYGTNTPPPSVPSSSHRRGVRQLPRN 645

[Close]

BLAST of Furin-1 vs. TrEMBL
Match: A0A4E0RKD3 (Furin OS=Fasciola hepatica OX=6192 GN=D915_000368 PE=3 SV=1)

HSP 1 Score: 748.814 bits (1932), Expect = 0.000e+0
Identity = 358/588 (60.88%), Postives = 439/588 (74.66%), Query Frame = 1

Query:  160 SQSESRGHYTDTWAVQINGTVDDARILAATYGFVFLNEIMPSIYSFKHRRVSKRSIYPSNYYQSNLSDDPRVIWLEQQFAKVRVKRHI---VNDPKWYKMWYLNKMNKEN-SMNIISAWKKGYRGQNVVVSILDDGIEKDHPDLKENYDPNASYDIISNDNNPEPRYISSNNTKIKDNHHGTRCAGQVAATANNRICGVGVAYKANIGGIRMLDGEVSDSVESHSLRLFYQHIDIYSASWGPEDDGKTVDGPGELAKIAFEDGILKGRNGLGSIFVWASGNGGKNHDNCNCDGYTNSIFTLGVNAVSEIGDAPWYAEKCSSTLAVTYSSGSMDERAIITTDVNHECTEQHSGTSASAPFAAGICALALSANRFLTWRDMQHLVVITARKANLRAVDWSTNAAGKEYSHSFGFGLMDAGAMVDLALNWTTVPEQHICHYVAPMQGGPISLKPYANEVLSITTDACSD------NSKKRVRYLEHVQAKISLRSTKRGEVELWLISPSRSTSKLLTKRRNDVASAGFHHWPFMSVHFWGEEAPGTWKLTIYSYDAEVTLINWSLILYGTDTLPSHRQNSTHTKSQKRPPK 1893
            + SE +  +T  WAV++ G  + AR +A  YGF ++ EIMP IY FK  R+SKRSIY S YY   L +DP+V+W EQQ  K RVKR +   VNDP W  MWYLN+       MN+ SAW +GY GQ+VVV+ILDDG+E DHPDLKENYDP ASYD+  ND+NPEPRY   ++     N HGTRCAG+VAA ANN +CG+G+AY+A IGG+RMLDG+VSD++ES SL    QHID+YSASWGPEDDGKTVDGPG LA++AF +GI  GR GLGSIFVWASGNGGK+ DNCNCDGYTNSI+TLGV++ SE G  PWYAE CSSTL VTYSSG   ER +ITTD+NH CT  HSGTSASAP AAGICA+ LSAN  LTWRD+Q+LVV TAR   L A DW  N  G+  SH+FG+GLMDAGAMVDLALNWT VP Q +C   AP+ GGP+S++P + E L++TTD C+       +  +RV YLEHVQAK+++ S +RGE+ELWL SPS + SKLL+KR  D+  AGFH WPFMSVH+WGE A GTWKLT++S  A V++ +W LILYGT+T P    +++H +  ++ PK
Sbjct:   63 TSSEKKPIFTPFWAVELQGGEEAAREIANKYGFTYIGEIMPGIYHFKQSRLSKRSIYHSIYYHDQLVEDPKVLWAEQQVVKTRVKRDVHIPVNDPHWPHMWYLNRGGSGGLDMNVRSAWARGYAGQDVVVTILDDGLETDHPDLKENYDPFASYDVNGNDDNPEPRY---HDKVTASNRHGTRCAGEVAAVANNSLCGLGIAYRARIGGVRMLDGDVSDAMESRSLGHQLQHIDVYSASWGPEDDGKTVDGPGRLAQLAFRNGIQMGRGGLGSIFVWASGNGGKSGDNCNCDGYTNSIYTLGVSSASEHGSVPWYAEMCSSTLTVTYSSGGHGERGVITTDLNHTCTNNHSGTSASAPLAAGICAVTLSANPRLTWRDLQYLVVYTARPDGLYADDWRVNGVGRRVSHAFGYGLMDAGAMVDLALNWTNVPPQRVCEAQAPITGGPVSVRPMSRENLALTTDGCASAAARAGDPSQRVVYLEHVQAKVTVSSAQRGEIELWLTSPSGTVSKLLSKRPKDIEVAGFHAWPFMSVHYWGELANGTWKLTVHSGKAAVSIHDWILILYGTNT-PPPMHDASHRRGVRQLPK 646

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BLAST of Furin-1 vs. TrEMBL
Match: G7YU09 (Furin OS=Clonorchis sinensis OX=79923 GN=CLF_110890 PE=3 SV=1)

HSP 1 Score: 748.429 bits (1931), Expect = 0.000e+0
Identity = 361/581 (62.13%), Postives = 439/581 (75.56%), Query Frame = 1

Query:  184 YTDTWAVQINGTVDDARILAATYGFVFLNEIMPSIYSFKHRRVSKRSIYPSNYYQSNLSDDPRVIWLEQQFAKVRVKRHI---VNDPKWYKMWYLNKMNKEN-SMNIISAWKKGYRGQNVVVSILDDGIEKDHPDLKENYDPNASYDIISNDNNPEPRYISSNNTKIKDNHHGTRCAGQVAATANNRICGVGVAYKANIGGIRMLDGEVSDSVESHSLRLFYQHIDIYSASWGPEDDGKTVDGPGELAKIAFEDGILKGRNGLGSIFVWASGNGGKNHDNCNCDGYTNSIFTLGVNAVSEIGDAPWYAEKCSSTLAVTYSSGSMDERAIITTDVNHECTEQHSGTSASAPFAAGICALALSANRFLTWRDMQHLVVITARKANLRAVDWSTNAAGKEYSHSFGFGLMDAGAMVDLALNWTTVPEQHICHYVAPMQGGPISLKPYANEVLSITTDACSDNSK------KRVRYLEHVQAKISLRSTKRGEVELWLISPSRSTSKLLTKRRNDVASAGFHHWPFMSVHFWGEEAPGTWKLTIYSYDAEVTLINWSLILYGTDTLPSHRQNSTHTKSQKRPPKN 1896
            +T  WAV+I    + AR +A  +GF+FL  I+P IY  K  R+S+RS++ S +Y   L++DPRV+WLEQQ AKVRVKR +   VNDP W  MWYLN+       MN+ SAW +GY GQ+VVV+ILDDG+E DHPDLKENYDP ASYD+  ND NPEPRY SS+      N HGTRCAG+VAA ANN ICG+G+AY+A IGG+RMLDG+VSD++ES SL    QHID+YSASWGPEDDGKTVDGPG LA++AF +GI+ GR GLGSIFVWASGNGGKN DNCNCDGYTNSI+TLGV++VSE G  PWYAE CSSTLAVTYSSG  +ER +ITTD+NH CT  HSGTSASAP AAGICAL LSAN+ LTWRD+Q+LVV TAR   L A DW  N  G+  SH+FG+GLMDAGAMVDLA+NWT VP Q +C   AP+ GGP+S++  + EVL++TTD C+  +       + V YLEHVQAK+++ S +RGE+EL L SPS + S LL+KR  D+  AGFH WPFMSVHFWGE A GTWKLT+YS  A V++ +W LILYGT+T P     S+H +  ++ PKN
Sbjct:   70 FTRYWAVEILEGEEVAREVAEKHGFIFLGTILPGIYYMKQPRLSRRSVHHSIHYHDQLANDPRVVWLEQQVAKVRVKRDVHIPVNDPHWADMWYLNRGGPNGLDMNVRSAWARGYAGQDVVVTILDDGLEIDHPDLKENYDPFASYDVNGNDANPEPRYPSSDKNP-ASNRHGTRCAGEVAAVANNSICGLGIAYRARIGGVRMLDGDVSDAMESRSLGYQLQHIDVYSASWGPEDDGKTVDGPGRLAQMAFRNGIVMGRGGLGSIFVWASGNGGKNGDNCNCDGYTNSIYTLGVSSVSERGSVPWYAEMCSSTLAVTYSSGGQEERGVITTDLNHTCTRNHSGTSASAPLAAGICALTLSANKRLTWRDLQYLVVYTARPEGLNASDWRVNGVGRSVSHAFGYGLMDAGAMVDLAINWTNVPPQRVCEAQAPITGGPVSVQRMSKEVLALTTDGCASTAAFAGDPTQCVVYLEHVQAKVTVSSAQRGEIELRLTSPSGTESILLSKRPKDMDVAGFHAWPFMSVHFWGEMANGTWKLTVYSGKASVSIHDWILILYGTNT-PPPLHASSHRRGVRQLPKN 648

[Close]

BLAST of Furin-1 vs. TrEMBL
Match: A0A074Z5Y0 (P/Homo B domain-containing protein OS=Opisthorchis viverrini OX=6198 GN=T265_09434 PE=3 SV=1)

HSP 1 Score: 748.043 bits (1930), Expect = 0.000e+0
Identity = 366/600 (61.00%), Postives = 444/600 (74.00%), Query Frame = 1

Query:  133 SSLFCFGAKSQSESRGH--YTDTWAVQINGTVDDARILAATYGFVFLNEIMPSIYSFKHRRVSKRSIYPSNYYQSNLSDDPRVIWLEQQFAKVRVKRHI---VNDPKWYKMWYLNKMNKEN-SMNIISAWKKGYRGQNVVVSILDDGIEKDHPDLKENYDPNASYDIISNDNNPEPRYISSNNTKIKDNHHGTRCAGQVAATANNRICGVGVAYKANIGGIRMLDGEVSDSVESHSLRLFYQHIDIYSASWGPEDDGKTVDGPGELAKIAFEDGILKGRNGLGSIFVWASGNGGKNHDNCNCDGYTNSIFTLGVNAVSEIGDAPWYAEKCSSTLAVTYSSGSMDERAIITTDVNHECTEQHSGTSASAPFAAGICALALSANRFLTWRDMQHLVVITARKANLRAVDWSTNAAGKEYSHSFGFGLMDAGAMVDLALNWTTVPEQHICHYVAPMQGGPISLKPYANEVLSITTDACSDNSK------KRVRYLEHVQAKISLRSTKRGEVELWLISPSRSTSKLLTKRRNDVASAGFHHWPFMSVHFWGEEAPGTWKLTIYSYDAEVTLINWSLILYGTDTLPSHRQNSTHTKSQKRPPKN 1896
            S  F  GA       G   +T  WAV+I    + AR +A  +GF+FL  I+P IY  K  R+S+RS++ S +Y   L++DPRV+WLEQQ AKVRVKR +   VNDP W  MWYLN+       MN+ SAW +GY GQ+VVV+ILDDG+E DHPDLKENYDP ASYD+  ND NPEPRY SS+      N HGTRCAG+VAA ANN ICG+G+AY+A IGG+RMLDG+VSD++ES SL    QHID+YSASWGPEDDGKTVDGPG LA++AF +GI+ GR GLGSIFVWASGNGGKN DNCNCDGYTNSI+TLGV++VSE G  PWYAE CSSTLAVTYSSG  +ER +ITTD+NH CT  HSGTSASAP AAGICAL LSAN+ LTWRD+Q+LVV TAR   L A DW  N  G+  SH+FG+GLMDAGAMVDLA+NWT VP Q +C   AP+ GGP+S++  + EVL++TTD C+  +       + V YLEHVQAK+++ S +RGE+EL L SPS + S LL+KR  D+  AGFH WPFMSVHFWGE A GTWKLT+YS  A V++ +W LILYGT+T P     S+H +  ++ PKN
Sbjct:   51 SMTFADGAAQHVSESGSPIFTRYWAVEILEGEEVAREVAEKHGFIFLGTILPGIYYMKQPRLSRRSVHHSIHYHDQLANDPRVVWLEQQVAKVRVKRDVHIPVNDPHWADMWYLNRGGPNGLDMNVRSAWARGYAGQDVVVTILDDGLEIDHPDLKENYDPFASYDVNGNDANPEPRYPSSDKNP-ASNRHGTRCAGEVAAVANNSICGLGIAYRARIGGVRMLDGDVSDAMESRSLGYQLQHIDVYSASWGPEDDGKTVDGPGRLAQMAFRNGIVMGRGGLGSIFVWASGNGGKNGDNCNCDGYTNSIYTLGVSSVSERGSVPWYAEMCSSTLAVTYSSGGQEERGVITTDLNHTCTRNHSGTSASAPLAAGICALTLSANKRLTWRDLQYLVVYTARPEGLNASDWRVNGVGRSVSHAFGYGLMDAGAMVDLAINWTNVPPQRVCEAQAPITGGPVSVQRMSKEVLALTTDGCASTAAFAGDPTQCVVYLEHVQAKVTVSSAQRGEIELRLTSPSGTESILLSKRPKDMDVAGFHAWPFMSVHFWGEMANGTWKLTVYSGKASVSIHDWILILYGTNT-PPPLHASSHRRGVRQLPKN 648

[Close]

BLAST of Furin-1 vs. TrEMBL
Match: A0A4S2L075 (P/Homo B domain-containing protein OS=Opisthorchis felineus OX=147828 GN=CRM22_010212 PE=3 SV=1)

HSP 1 Score: 746.888 bits (1927), Expect = 0.000e+0
Identity = 360/581 (61.96%), Postives = 439/581 (75.56%), Query Frame = 1

Query:  184 YTDTWAVQINGTVDDARILAATYGFVFLNEIMPSIYSFKHRRVSKRSIYPSNYYQSNLSDDPRVIWLEQQFAKVRVKRHI---VNDPKWYKMWYLNKMNKEN-SMNIISAWKKGYRGQNVVVSILDDGIEKDHPDLKENYDPNASYDIISNDNNPEPRYISSNNTKIKDNHHGTRCAGQVAATANNRICGVGVAYKANIGGIRMLDGEVSDSVESHSLRLFYQHIDIYSASWGPEDDGKTVDGPGELAKIAFEDGILKGRNGLGSIFVWASGNGGKNHDNCNCDGYTNSIFTLGVNAVSEIGDAPWYAEKCSSTLAVTYSSGSMDERAIITTDVNHECTEQHSGTSASAPFAAGICALALSANRFLTWRDMQHLVVITARKANLRAVDWSTNAAGKEYSHSFGFGLMDAGAMVDLALNWTTVPEQHICHYVAPMQGGPISLKPYANEVLSITTDACSDNSK------KRVRYLEHVQAKISLRSTKRGEVELWLISPSRSTSKLLTKRRNDVASAGFHHWPFMSVHFWGEEAPGTWKLTIYSYDAEVTLINWSLILYGTDTLPSHRQNSTHTKSQKRPPKN 1896
            +T  WAV+I    + AR +A  +GF+FL  I+P IY  K  R+S+RS++ S +Y   L++DPRV+WLEQQ AKVRVKR +   VNDP W  MWYLN+       MN+ SAW +GY GQ+VVV+ILDDG+E DHPDLKENYDP ASYD+  ND NPEPRY SS+      N HGTRCAG+VAA ANN ICG+G+AY+A IGG+RMLDG+VSD++ES SL    QHID+YSASWGPEDDGKTVDGPG LA++AF +GI+ GR GLGSIFVWASGNGGKN DNCNCDGYTNSI+TLGV++VSE G  PWYAE CSSTLAVTYSSG  +ER +ITTD+NH CT  HSGTSASAP AAGICAL LSAN+ LTWRD+Q+LVV TAR   L A DW  N  G+  SH+FG+GLMDAGAMVDLA+NW+ VP Q +C   AP+ GGP+S++  + EVL++TTD C+  +       + V YLEHVQAK+++ S +RGE+EL L SPS + S LL+KR  D+  AGFH WPFMSVHFWGE A GTWKLT+YS  A V++ +W LILYGT+T P     S+H +  ++ PKN
Sbjct:   70 FTRYWAVEILEGEEVAREVAEKHGFIFLGTILPGIYYMKQPRLSRRSVHHSIHYHDQLANDPRVVWLEQQVAKVRVKRDVHIPVNDPHWADMWYLNRGGPNGLDMNVRSAWARGYAGQDVVVTILDDGLEIDHPDLKENYDPFASYDVNGNDANPEPRYPSSDKNP-ASNRHGTRCAGEVAAVANNSICGLGIAYRARIGGVRMLDGDVSDAMESRSLGYQLQHIDVYSASWGPEDDGKTVDGPGRLAQMAFRNGIVMGRGGLGSIFVWASGNGGKNGDNCNCDGYTNSIYTLGVSSVSERGSVPWYAEMCSSTLAVTYSSGGQEERGVITTDLNHTCTRNHSGTSASAPLAAGICALTLSANKRLTWRDLQYLVVYTARPEGLNASDWRVNGVGRSVSHAFGYGLMDAGAMVDLAINWSNVPPQRVCEAQAPITGGPVSVQRMSKEVLALTTDGCASTAAFAGDPTQCVVYLEHVQAKVTVSSAQRGEIELRLTSPSGTESILLSKRPKDMDVAGFHAWPFMSVHFWGEMANGTWKLTVYSGKASVSIHDWILILYGTNT-PPPLHASSHRRGVRQLPKN 648

[Close]

BLAST of Furin-1 vs. Ensembl Cavefish
Match: pcsk6 (proprotein convertase subtilisin/kexin type 6 [Source:NCBI gene;Acc:103021799])

HSP 1 Score: 587.03 bits (1512), Expect = 0.000e+0
Identity = 301/593 (50.76%), Postives = 398/593 (67.12%), Query Frame = 1

Query:  124 ILFSSLFCFGAKSQSESRGHYTDTWAVQINGTVDDARILAATYGFVFLNEI--MPSIYSFKHRRVSKRSIYPSNYYQSNLSDDPRVIWLEQQFAKVRVKRHI--------VNDPKWYKMWYLNKMNK---ENSMNIISAWKKGYRGQNVVVSILDDGIEKDHPDLKENYDPNASYDIISNDNNPEPRYISSNNTKIKDNHHGTRCAGQVAATANNRICGVGVAYKANIGGIRMLDGEVSDSVESHSLRLFYQHIDIYSASWGPEDDGKTVDGPGELAKIAFEDGILKGRNGLGSIFVWASGNGGKNHDNCNCDGYTNSIFTLGVNAVSEIGDAPWYAEKCSSTLAVTYSSGSMDERAIITTDVNHECTEQHSGTSASAPFAAGICALALSANRFLTWRDMQHLVVITARKANLRAVDWSTNAAGKEYSHSFGFGLMDAGAMVDLALNWTTVPEQHICHYVAPMQGGPISLKPYANEVLSITTDACSDNSKKRVRYLEHVQAKISLRSTKRGEVELWLISPSRSTSKLLTKRRNDVASAGFHHWPFMSVHFWGEEAPGTWKLTIYSYDAEV-------TLINWSLILYGTDTLP 1842
            + F  L  F     S SR  +T+ WAV++ G  ++A  LA+ YGF  L +I  +   Y F H RV +RS + +    S +  DP+V W++QQ  K RVKR+          NDPKW  MWY++  +     + MNI++AW++GY G+N+V++ILDDGIE++HPDL  NYD  ASYD+  ND++P PRY SSN     +N HGTRCAG+VAA ANN  C VG+A+ A IGGIRMLDG+V+D VE+ SL +   +IDIYSASWGP+DDGKTVDGPG LAK AFE GI KGR GLGSIFVWASGNGG+  D+C+CDGYTNSI+T+ V++ +E G+ PWY E CSSTLA TYSSG   +R I+TTD+   CT+ H+GTS SAP  AG+ ALAL AN  +TWRD+QHL+V T+R  +L+A DW TNAAG + SH +GFGL+DA AMV  A  W +VP QH C  +A  +   I  +P      SI++  C D  +++V YLEHV  ++ +   +RG++E+ LISPS + S+LL KR  D ++ GF +W FM+VH WGE+A GTW L I    +++        L  W+LIL+GT   P
Sbjct:    4 LAFLVLSTFSVCEASPSRSVFTNHWAVRVTGGPEEADKLASKYGFANLGQIGGLEDHYHFHHSRVVRRSTFATRGAHSFIHMDPKVDWVQQQVVKSRVKRYARSDPNFIYFNDPKWSNMWYIHCSDNSRCRSEMNILAAWQRGYTGRNIVITILDDGIERNHPDLALNYDQLASYDVNGNDHDPTPRYDSSN-----ENKHGTRCAGEVAAVANNSHCIVGIAHNARIGGIRMLDGDVTDVVEAKSLGIRPDYIDIYSASWGPDDDGKTVDGPGPLAKQAFEVGIKKGRKGLGSIFVWASGNGGRQGDHCSCDGYTNSIYTISVSSSTENGNKPWYLEVCSSTLATTYSSGEFYDRKIVTTDLRQRCTDGHTGTSVSAPMVAGVIALALEANPLITWRDVQHLLVKTSRPVHLKASDWKTNAAGHKVSHLYGFGLVDAEAMVLEAKKWRSVPSQHTCIKMADRRTRYI--RPDQKLNASISSTGCRDQPEEQVVYLEHVVVRVLINHPRRGDLEISLISPSGTRSQLLAKRLFDNSNEGFRNWEFMTVHCWGEKAEGTWTLEISESPSQLRNPEILGKLKEWTLILHGTAEHP 589

[Close]

BLAST of Furin-1 vs. Ensembl Cavefish
Match: furina (furin-1-like [Source:NCBI gene;Acc:103024357])

HSP 1 Score: 582.793 bits (1501), Expect = 0.000e+0
Identity = 297/555 (53.51%), Postives = 379/555 (68.29%), Query Frame = 1

Query:  184 YTDTWAVQINGTVDDARILAATYGFVFLNEIMPSIYSFKHRRVSKRSIYPSNYYQSNLSDDPRVIWLEQQFAKVRVKRHIVN---DPKWYKMWYLNKMNKENSMNIISAWKKGYRGQNVVVSILDDGIEKDHPDLKENYDPNASYDIISNDNNPEPRYISSNNTKIKDNHHGTRCAGQVAATANNRICGVGVAYKANIGGIRMLDGEVSDSVESHSLRLFYQHIDIYSASWGPEDDGKTVDGPGELAKIAFEDGILKGRNGLGSIFVWASGNGGKNHDNCNCDGYTNSIFTLGVNAVSEIGDAPWYAEKCSSTLAVTYSSGSMDERAIITTDVNHECTEQHSGTSASAPFAAGICALALSANRFLTWRDMQHLVVITARKANLRAVDWSTNAAGKEYSHSFGFGLMDAGAMVDLALNWTTVPEQHICHYVAPMQGGPISLKPYANEVLSITTDACSDNSKKRVRYLEHVQAKISLRSTKRGEVELWLISPSRSTSKLLTKRRNDVASAGFHHWPFMSVHFWGEEAPGTWKLTIYSYDAEV---TLINWSLILYGT 1830
            YT+TWAV I G  ++A  LA  + F+    I    Y F+HRRV KRS+         L  +P+V W EQQ  K R KR I +   DPK+ + WYL   N  + +N+  AWK+G  G+ VVVSILDDGIE +HPDL+ NYDP+ASYD+   D +P+PRY     T++ DN HGTRCAG+VAA ANN ICGVGVAY A IGG+RMLDGEV+D+VE+ SL L  QHIDIYSASWGPEDDGKTVDGP +LAK AF  G+ +GR GLGSIFVWASGNGG+  D+CNCDGYTNSI+TL +++ ++ G+ PWY+E CSSTLA TYSSG ++E+ IITTD+  +CT+ H+GTSASAP AAGI ALAL AN+ LTWRDMQHLVV T+  A+L   DW TN  G++ SHS+G+GL+DA A+V LA NWT V  Q  C  V  +   P ++  +   V+S   D+C+      V  LEH QA+++L   +RG + ++LISP  + S LL  R +D +S GF+ W FM+ H W E+  G W L I +        TL  ++LILYGT
Sbjct:   30 YTNTWAVHITGGEEEANRLARKHDFINHGNIFGDYYHFRHRRVVKRSLSEHRGTHIRLHREPQVSWAEQQVVKRRKKRDIYSEPADPKFAQQWYLYNSNHRD-LNVKEAWKQGVTGKGVVVSILDDGIEMNHPDLERNYDPDASYDVNDGDPDPQPRY-----TQLNDNRHGTRCAGEVAAVANNDICGVGVAYNAKIGGVRMLDGEVTDAVEAQSLSLNPQHIDIYSASWGPEDDGKTVDGPAKLAKDAFLRGVTEGRGGLGSIFVWASGNGGREKDSCNCDGYTNSIYTLSISSSTQYGNVPWYSEACSSTLATTYSSGGLNEKQIITTDLRQKCTDSHTGTSASAPLAAGIIALALEANKNLTWRDMQHLVVRTSNPAHLTTDDWRTNGVGRKVSHSYGYGLLDAAAIVALAKNWTNVGPQQKC--VLSLVSEPKNIGSHL--VISKNVDSCA-GKPNFVSSLEHAQAQLTLSYNRRGNLAIYLISPQGTRSTLLAGRPHDYSSEGFNDWAFMTTHSWDEDPRGEWTLEIENKAGLSDFGTLTQFTLILYGT 573

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Query:  184 YTDTWAVQINGTVDDARILAATYGFVFLNEIMPSIYSFKHRRVSKRSIYPSNYYQSNLSDDPRVIWLEQQFAKVRVKRHIVN---DPKWYKMWYLNKMNKENSMNIISAWKKGYRGQNVVVSILDDGIEKDHPDLKENYDPNASYDIISNDNNPEPRYISSNNTKIKDNHHGTRCAGQVAATANNRICGVGVAYKANIGGIRMLDGEVSDSVESHSLRLFYQHIDIYSASWGPEDDGKTVDGPGELAKIAFEDGILKGRNGLGSIFVWASGNGGKNHDNCNCDGYTNSIFTLGVNAVSEIGDAPWYAEKCSSTLAVTYSSGSMDERAIITTDVNHECTEQHSGTSASAPFAAGICALALSANRFLTWRDMQHLVVITARKANLRAVDWSTNAAGKEYSHSFGFGLMDAGAMVDLALNWTTVPEQHICHYVAPMQGGPISLKPYANEVLSITTDACSDNSKKRVRYLEHVQAKISLRSTKRGEVELWLISPSRSTSKLLTKRRNDVASAGFHHWPFMSVHFWGEEAPGTWKLTIYSYDAEV---TLINWSLILYGT 1830
            YT+TWAV I G  ++A  LA  + F+    I    Y F+HRRV KRS+         L  +P+V W EQQ  K R KR I +   DPK+ + WYL   N  + +N+  AWK+G  G+ VVVSILDDGIE +HPDL+ NYDP+ASYD+   D +P+PRY     T++ DN HGTRCAG+VAA ANN ICGVGVAY A IGG+RMLDGEV+D+VE+ SL L  QHIDIYSASWGPEDDGKTVDGP +LAK AF  G+ +GR GLGSIFVWASGNGG+  D+CNCDGYTNSI+TL +++ ++ G+ PWY+E CSSTLA TYSSG ++E+ IITTD+  +CT+ H+GTSASAP AAGI ALAL AN+ LTWRDMQHLVV T+  A+L   DW TN  G++ SHS+G+GL+DA A+V LA NWT V  Q  C  V  +   P ++  +   V+S   D+C+      V  LEH QA+++L   +RG + ++LISP  + S LL  R +D +S GF+ W FM+ H W E+  G W L I +        TL  ++LILYGT
Sbjct:   30 YTNTWAVHITGGEEEANRLARKHDFINHGNIFGDYYHFRHRRVVKRSLSEHRGTHIRLHREPQVSWAEQQVVKRRKKRDIYSEPADPKFAQQWYLYNSNHRD-LNVKEAWKQGVTGKGVVVSILDDGIEMNHPDLERNYDPDASYDVNDGDPDPQPRY-----TQLNDNRHGTRCAGEVAAVANNDICGVGVAYNAKIGGVRMLDGEVTDAVEAQSLSLNPQHIDIYSASWGPEDDGKTVDGPAKLAKDAFLRGVTEGRGGLGSIFVWASGNGGREKDSCNCDGYTNSIYTLSISSSTQYGNVPWYSEACSSTLATTYSSGGLNEKQIITTDLRQKCTDSHTGTSASAPLAAGIIALALEANKNLTWRDMQHLVVRTSNPAHLTTDDWRTNGVGRKVSHSYGYGLLDAAAIVALAKNWTNVGPQQKC--VLSLVSEPKNIGSHL--VISKNVDSCA-GKPNFVSSLEHAQAQLTLSYNRRGNLAIYLISPQGTRSTLLAGRPHDYSSEGFNDWAFMTTHSWDEDPRGEWTLEIENKAGLSDFGTLTQFTLILYGT 573

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BLAST of Furin-1 vs. Ensembl Cavefish
Match: furinb (furin [Source:NCBI gene;Acc:103043208])

HSP 1 Score: 581.252 bits (1497), Expect = 0.000e+0
Identity = 292/560 (52.14%), Postives = 383/560 (68.39%), Query Frame = 1

Query:  169 ESRGHYTDTWAVQINGTVDDARILAATYGFVFLNEIMPSIYSFKHRRVSKRSIYPSNYYQSNLSDDPRVIWLEQQFAKVRVKRHIVN---DPKWYKMWYLNKMNKENSMNIISAWKKGYRGQNVVVSILDDGIEKDHPDLKENYDPNASYDIISNDNNPEPRYISSNNTKIKDNHHGTRCAGQVAATANNRICGVGVAYKANIGGIRMLDGEVSDSVESHSLRLFYQHIDIYSASWGPEDDGKTVDGPGELAKIAFEDGILKGRNGLGSIFVWASGNGGKNHDNCNCDGYTNSIFTLGVNAVSEIGDAPWYAEKCSSTLAVTYSSGSMDERAIITTDVNHECTEQHSGTSASAPFAAGICALALSANRFLTWRDMQHLVVITARKANLRAVDWSTNAAGKEYSHSFGFGLMDAGAMVDLALNWTTVPEQHICHYVAPMQGGPISLKPYANEVLSITTDACSDNSKKRVRYLEHVQAKISLRSTKRGEVELWLISPSRSTSKLLTKRRNDVASAGFHHWPFMSVHFWGEEAPGTWKLTIYSYDAEV---TLINWSLILYGT 1830
            E +G YTD+WAV I G  ++A+ +A  + F++   +    Y F+HR V KRS+         L  +P+V+W EQQ AK R KR I +   DPK+ + WYL   N+ + +++  AW +G+ G+ VV++ILDDGIEKDHPDL +NYDP+ASYD+   D +P+PRY     T++ DN HGTRCAG+VAA ANN +CGVGVAY A IGG+RMLDGEV+D VE+ SL L  QHI IYSASWGPEDDGKTVDGP +LAK AF  G+ +GR GLGSIFVWASGNGG+  D+CNCDGYTNSI+TL +++ ++ G+ PWY+E CSSTLA TYSSG+++E+ I+TTD+  +CT+ H+GTSASAP AAGI ALAL AN  LTWRDMQHLVV T+  A+L   DW TN  G+  SHS+G+GL+DA AMV LA NW++V  QH C  V  M   P  ++ +   + S + +ACS      V  LEHVQA+++L  + RG + + LISP  + S LL  R  D ++ GF+ W FM+ H W E+  G W L I +         L  ++L LYGT
Sbjct:   25 EIQGLYTDSWAVHIRGGEEEAQRIAHKHNFIYHGNVFGDYYHFQHRSVVKRSLSGHRGVHVRLQSEPQVVWAEQQVAKRRRKRDIYSEPTDPKFPQQWYLYNPNRRD-LHVKEAWAQGFTGRGVVITILDDGIEKDHPDLAQNYDPDASYDVNDRDPDPQPRY-----TQLNDNRHGTRCAGEVAAAANNGVCGVGVAYNARIGGVRMLDGEVTDVVEAQSLSLNLQHIHIYSASWGPEDDGKTVDGPAKLAKEAFLQGVTEGRGGLGSIFVWASGNGGREKDSCNCDGYTNSIYTLSISSTTQYGNVPWYSEACSSTLATTYSSGNLNEKQIVTTDLRKKCTDSHTGTSASAPLAAGIIALALEANMNLTWRDMQHLVVRTSHPAHLITSDWRTNGVGRLVSHSYGYGLLDASAMVALARNWSSVGPQHKC--VIDMLTEPRDVRNHL--MFSKSVEACS-GQPDFVSSLEHVQARLTLSYSHRGNLAIHLISPLGTRSTLLHPRPQDNSAEGFNDWAFMTTHAWDEDPRGEWTLEIENVAGLSDYGVLSQFTLFLYGT 573

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BLAST of Furin-1 vs. Ensembl Cavefish
Match: pcsk5b (proprotein convertase subtilisin/kexin type 5 [Source:NCBI gene;Acc:103025246])

HSP 1 Score: 575.474 bits (1482), Expect = 0.000e+0
Identity = 303/607 (49.92%), Postives = 384/607 (63.26%), Query Frame = 1

Query:  118 FVILFSSLFCFGAKSQSESRGHYTDTWAVQINGTVDDARILAATYGFVFLNEI--MPSIYSFKHRRVSKRSIYPSNYYQSNLSDDPRVIWLEQQFAKVRVKRH-------------------IVNDPKWYKMWYL----NKMNKENSMNIISAWKKGYRGQNVVVSILDDGIEKDHPDLKENYDPNASYDIISNDNNPEPRYISSNNTKIKDNHHGTRCAGQVAATANNRICGVGVAYKANIGGIRMLDGEVSDSVESHSLRLFYQHIDIYSASWGPEDDGKTVDGPGELAKIAFEDGILKGRNGLGSIFVWASGNGGKNHDNCNCDGYTNSIFTLGVNAVSEIGDAPWYAEKCSSTLAVTYSSGSMDERAIITTDVNHECTEQHSGTSASAPFAAGICALALSANRFLTWRDMQHLVVITARKANLRAVDWSTNAAGKEYSHSFGFGLMDAGAMVDLALNWTTVPEQHICHYVAPMQGGPISLKPYANEVLSITTDACSDNSKKRVRYLEHVQAKISLRSTKRGEVELWLISPSRSTSKLLTKRRNDVASAGFHHWPFMSVHFWGEEAPGTWKLTIYSYDAEV-------TLINWSLILYGTDTLP 1842
              +L    F F A  ++     YT+ WAV+I G  + A  +A+ YG+  L +I  +   Y F H R  KRS   S    S +S +P+V W+EQQ  K RVKR                      ND KW  MWY+    N  N ++ MNI+ AWK+GY G++VVV+ILDDGIE++HPDL +NYD  ASYD+  ND +P PRY  SN     +N HGTRCAG+VAA+ANN  C VG+AY A IGG+RMLDG+V+D VE+ SL L  QHIDIYSASWGP+DDGKTVDGP  LA+ AFE+GI  GR G GSIFVWASGNGG++ D+C+CDGYTNSI+T+ +++ +E G  PWY E+C+STL  TYSSG   +R IITTD+   CT+ H+GTSASAP AAGI ALAL AN  LTWRD+QH++V T+R  +L A DW TNAAG   SH +GFGLMDA AMV  A  W  VP QHIC   A  Q   I  +     V   T   C+DN+   V YLEHV  +I++   +RG++ + L SPS + S+LL  R  D +  GF +W FM+ H WGE+A G W L I    +++        L  WSL+LYGT   P
Sbjct:   12 LCVLALGFFSFFAPCKARI---YTNHWAVRITGGAELAERIASRYGYRNLGQIGDLKDYYHFFHSRTIKRSTLSSRGTHSFISMEPKVQWMEQQVVKRRVKRDYKSSYTSAVQSSPAQSDSIFFNDAKWSSMWYIHCNDNIHNCQSDMNIVGAWKRGYTGKDVVVTILDDGIERNHPDLVQNYDNQASYDVNGNDLDPMPRYDVSN-----ENKHGTRCAGEVAASANNSHCTVGIAYNAKIGGVRMLDGDVTDMVEAKSLSLHPQHIDIYSASWGPDDDGKTVDGPAALARQAFENGIRLGRKGRGSIFVWASGNGGRSRDHCSCDGYTNSIYTISISSTAESGRKPWYLEECASTLTTTYSSGENYDRKIITTDLRQRCTDSHTGTSASAPMAAGIIALALEANTLLTWRDVQHIIVKTSRAGHLSAPDWKTNAAGYNVSHLYGFGLMDAEAMVKEAERWKPVPPQHICVENADKQIRTIRPEHVVRSVYKAT--GCTDNANNHVIYLEHVVVRITITHPRRGDLSINLTSPSGTKSQLLANRLFDHSMEGFKNWEFMTTHCWGEKAAGDWILEINDTPSQLRSQKTPGKLKEWSLVLYGTSVHP 608

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BLAST of Furin-1 vs. Ensembl Sea Lamprey
Match: pcsk7 (proprotein convertase subtilisin/kexin type 7 [Source:ZFIN;Acc:ZDB-GENE-030131-7293])

HSP 1 Score: 185.267 bits (469), Expect = 1.844e-53
Identity = 109/231 (47.19%), Postives = 150/231 (64.94%), Query Frame = 1

Query:  373 VIWLEQQFAKVRVKRHI-VNDPKWYKMWYLNKMNKENSM--NIISAWKKGYRGQNVVVSILDDGIEKDHPDLKENYDPNASYDIISNDNNPEPRYISSNNTKIKDNHHGTRCAGQVAATANNRICGVGVAYKANIGGIRMLDGEVSDSVESHSLRLFYQHIDIYSASWGPEDDGKTVDGPGELAKIAFEDGILKGRNGLGSIFVWASGNGGKNHDNCNCDGYTNSIFTLGV 1056
            V+W  +Q    RVKR +  NDPK+ K W+L +      M  N+   W++G  G+ VVV+++DDG+E   PDL+ NY    SYD+   D +P P       T  +++ HGTRCAG++AA ANN +CGVG AY + + GIR+LDG ++D +E+ +    YQ   IYS SWGP+DDGKTVDGP  L + A + G++ GR G G+IFV ASGNGG+  DNCN DGY NSI+T+ +
Sbjct:   59 VLWSVEQKGLRRVKRSLPFNDPKFPKQWHLQRNTHTPGMDLNVTGVWERGVTGKGVVVAVVDDGVEHTLPDLQSNYCAEGSYDLTDGDQDPRP------GTGDQESRHGTRCAGEIAAVANNSLCGVGAAYDSRVAGIRLLDGPLTDHMEATAFNTHYQLNHIYSCSWGPDDDGKTVDGPHVLGQSALQRGVVGGRRGFGTIFVVASGNGGRYQDNCNYDGYANSIYTITI 283

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BLAST of Furin-1 vs. Ensembl Sea Lamprey
Match: pcsk2 (proprotein convertase subtilisin/kexin type 2 [Source:ZFIN;Acc:ZDB-GENE-090608-1])

HSP 1 Score: 181.415 bits (459), Expect = 3.848e-51
Identity = 118/339 (34.81%), Postives = 175/339 (51.62%), Query Frame = 1

Query:  943 KGRNGLGSIFVWASGNGGKNHDNCNCDGYTNSIFTLGVNAVSEIGDAPWYAEKCSSTLAVTYSSGSMD--ERAIITTDVNHECTEQHSGTSASAPFAAGICALALSAN---------RFLTWRDMQHLVVITARKANLRAVDWSTNAAGKEYSHSFGFGLMDAGAMVDLALNWTTVPEQHICHYVAPMQGGP----------ISLKPYA------NEVLSITTDACSDNSKKRVRYLEHVQAKISLRSTKRGEVELWLISPSRSTSKLLTKRRNDVAS-AGFHHWPFMSVHFWGEEAPGTWKLTI-----------YSYDAEVTLINWSLILYGTDTLP 1842
            +GR G GS++VWASG+GG ++D+CNCDGY +S++T+ +N+    G    Y E CSSTLA T+S+G     E  + TTD+   CT +HSGTSA+AP AAG+ ALA+ AN         R  T  D      +T  +  L  +    +   +  +H   F   D    +    + +T  +QH+  + +P +  P          +   P +        VL++ TDAC +     VRYLEHVQ  +++ +T+RG++ L L SP  + S LL +R  D  S  GFH WPFM+ H WGE+  G W L +            +      L  W+L+L+GT + P
Sbjct:    1 QGRGGKGSVYVWASGDGG-SYDDCNCDGYASSMWTISINSAINDGRTALYDESCSSTLASTFSNGRKKDPEAGVATTDLYGNCTLRHSGTSAAAPEAAGVFALAIEANHPETAPCIARRTTTSDANRAFFVTKSRGFL-GICHDFHLQKQPTTHLTAFRGEDVCCDIAGHFSRSTEQQQHLATFRSPFRTFPPLRSRSPCRCVPCVPCSAVPGQGRLVLTVDTDAC-EGRADHVRYLEHVQVVVTVNATRRGDLTLNLTSPMGTRSLLLGRRPRDSDSRVGFHRWPFMTTHTWGEDPRGRWTLEVGFADGAEGPAAAAAARSGVLSEWTLMLHGTHSPP 336

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BLAST of Furin-1 vs. Ensembl Sea Lamprey
Match: pcsk2 (proprotein convertase subtilisin/kexin type 2 [Source:ZFIN;Acc:ZDB-GENE-090608-1])

HSP 1 Score: 172.17 bits (435), Expect = 4.802e-48
Identity = 116/323 (35.91%), Postives = 170/323 (52.63%), Query Frame = 1

Query:  943 KGRNGLGSIFVWASGNGGKNHDNCNCDGYTNSIFTLGVNAVSEIGDAPWYAEKCSSTLAVTYSSGSMD--ERAIITTDVNHECTEQHSGTSASAPFAAGICALALSANRFLTWRDMQHLVVIT--------ARKANLRAVDWSTNAAGKEYSHSFGFGLMDAGAMVDLALNWTTVPEQHICHYVAPMQGGPISLKPYANE-VLSITTDACSDNSKKRVRYLEHVQAKISLRSTKRGEVELWLISPSRSTSKLLTKR-RNDVASAGFHHWPFMSVHFWGEEAPGTWKLTI-----------YSYDAEVTLINWSLILYGTDTLP 1842
            +GR G GS++VWASG+GG ++D+CNCDGY +S++T+ +N+    G    Y E CSSTLA T+S+G     E  + TTD+   CT +HSGTSA+AP AAG+ ALA+ A       +    V +            A   A   +T+ A + +  +   G +  G   D  L      +Q   H  A  +G  +   P     VL++ TDAC +     VRYLEHVQ  +++ +T+RG++ L L SP  + S LL +R R+  +  GFH WPFM+ H WGE+  G W L +            +      L  W+L+L+GT + P
Sbjct:    1 QGRGGKGSVYVWASGDGG-SYDDCNCDGYASSMWTISINSAINDGRTALYDESCSSTLASTFSNGRKKDPEAGVATTDLYGNCTLRHSGTSAAAPEAAGVFALAIEAKGVEWLHNTSASVSLLPHSRSQSHPETAPCIARRTTTSDANRAFFVTKSRGFL--GICHDFHLQ-----KQPTTHLTA-FRGEDVCAVPGQGRLVLTVDTDAC-EGRADHVRYLEHVQVVVTVNATRRGDLTLNLTSPMGTRSLLLGRRPRDSDSRVGFHRWPFMTTHTWGEDPRGRWTLEVGFADGAEGPAAAAAARSGVLSEWTLMLHGTHSPP 313

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BLAST of Furin-1 vs. Ensembl Sea Lamprey
Match: ENSPMAT00000001746.1 (pep scaffold:Pmarinus_7.0:GL481393:30496:45513:1 gene:ENSPMAG00000001582.1 transcript:ENSPMAT00000001746.1 gene_biotype:protein_coding transcript_biotype:protein_coding)

HSP 1 Score: 142.895 bits (359), Expect = 2.404e-39
Identity = 77/184 (41.85%), Postives = 110/184 (59.78%), Query Frame = 1

Query:  127 LFSSLFCFGAKSQSESRGHYTDTWAVQINGTVDDARILAATYGFVFLNEIMPSIYSFKHRRVSKRSIYPSNYYQSNLSDDPRVIWLEQQFAKVRVKRHIVN---DPKWYKMWYLNKMNKENSMNIISAWKKGYRGQNVVVSILDDGIEKDHPDLKENYDPNASYDIISNDNNPEPRYISSNNTK 669
            L  +++     ++ + R  YT TWAV + G    A  +A  +GF  L +I    Y F+HR V+KRS+   +     L  +P+V W EQQ  K R KR +     DPK+   WYL+  +  + +N+++AW +G  G+ VVVSILDDGIEK+HPDL  NYDP ASYD+ SND +P+PRY   N+ +
Sbjct:   13 LACAVWLVAGGARGQQRDVYTHTWAVLVPGGAAAADDVAGRHGFTNLGQIFGDYYHFRHRAVAKRSLSRHHNRNLKLQKEPKVQWAEQQVVKARRKRELFQEPTDPKYLLQWYLHN-SVHHDLNVLAAWSQGVSGRGVVVSILDDGIEKNHPDLVSNYDPMASYDVNSNDPDPQPRYTEMNDNR 195

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BLAST of Furin-1 vs. Ensembl Yeast
Match: KEX2 (Kexin, a subtilisin-like protease (proprotein convertase); a calcium-dependent serine protease involved in the activation of proproteins of the secretory pathway [Source:SGD;Acc:S000005182])

HSP 1 Score: 343.584 bits (880), Expect = 5.226e-107
Identity = 189/476 (39.71%), Postives = 277/476 (58.19%), Query Frame = 1

Query:  424 VNDPKWYKMWYL-NKMNKENSMNIISAWKKGYRGQNVVVSILDDGIEKDHPDLKENYDPNASYDIISNDNNPEPRYISSNNTKIKDNHHGTRCAGQVAATANNRICGVGVAYKANIGGIRMLDGEVSDSVESHSLRLFYQHIDIYSASWGPEDDGKTVDGPGELAKIAFEDGILKGRNGLGSIFVWASGNGGKNHDNCNCDGYTNSIFTLGVNAVSEIGDAPWYAEKCSSTLAVTYSSGSMDERAIITTDVNHECTEQHSGTSASAPFAAGICALALSANRFLTWRDMQHLVVITARKANLRA-VDWSTNAAGKEYSHSFGFGLMDAGAMVDLALNWTTVPEQHICH----YVAPMQGGPISLKPYANEVLSITTDACSDNSKKRVRYLEHVQAKISLRSTKRGEVELWLISPSRSTSKLLTKRRNDVASAGFHHWPFMSVHFWGEEAPGTWKLTIYSYDA--EVTLINWSLILYG 1827
            +NDP + + W+L N     + +N++  W     G  VV +I+DDG++ ++ DLK+N+    S+D   N N P+PR        + D++HGTRCAG++AA   N  CGVGV Y A I GIR+L G+++   E+ SL       DIYS SWGP DDG+ + GP +L K A   G+ +GR+  G+I+V+ASGNGG   DNCN DGYTNSI+++ + A+      P Y+E CS+ +AVTYSSGS +   I ++D+N  C+  H GTSA+AP AAG+  L L AN  LTWRD+Q+L +++A      A  DW  +A GK+YSH +GFG +DA  +++++  W  V  Q   +    YV+       S +     V++I+  +  D + KR+   EHV   + + +  RG   + LISP+   S L   R  DV+S GF  W FMSV  WGE   G WK+ + + +    +   +W L L+G
Sbjct:  133 INDPLFERQWHLVNPSFPGSDINVLDLWYNNITGAGVVAAIVDDGLDYENEDLKDNFCAEGSWDFNDNTNLPKPR--------LSDDYHGTRCAGEIAAKKGNNFCGVGVGYNAKISGIRILSGDITTEDEAASLIYGLDVNDIYSCSWGPADDGRHLQGPSDLVKKALVKGVTEGRDSKGAIYVFASGNGGTRGDNCNYDGYTNSIYSITIGAIDHKDLHPPYSEGCSAVMAVTYSSGSGE--YIHSSDINGRCSNSHGGTSAAAPLAAGVYTLLLEANPNLTWRDVQYLSILSAVGLEKNADGDWRDSAMGKKYSHRYGFGKIDAHKLIEMSKTWENVNAQTWFYLPTLYVSQSTN---STEETLESVITISEKSLQDANFKRI---EHVTVTVDIDTEIRGTTTVDLISPAGIISNLGVVRPRDVSSEGFKDWTFMSVAHWGENGVGDWKIKVKTTENGHRIDFHSWRLKLFG 592

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BLAST of Furin-1 vs. Ensembl Nematostella
Match: EDO47748 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7RLT1])

HSP 1 Score: 520.776 bits (1340), Expect = 2.517e-177
Identity = 281/592 (47.47%), Postives = 368/592 (62.16%), Query Frame = 1

Query:  151 GAKSQSESRGHYTDTWAVQINGTVDDARILAATYGFVFLNEI--MPSIYSFKHRRVSKRSIYPSNYYQSNLSDDPRVIWLEQQFAKVRVKRHI-------------VNDPKWYKMWYLNKMNKENSMNI--ISAWKKGYRGQNVVVSILDDGIEKDHPDLKENYDPNASYDIISNDNNPEPRYISSNNTKIKDNHHGTRCAGQVAATANNRICGVGVAYKANIGGIRMLDGEVSDSVESHSLRLFYQHIDIYSASWGPEDDGKTVDGPGELAKIAFEDGILKGRNGLGSIFVWASGNGGKNHDNCNCDGYTNSIFTLGVNAVSEIGDAPWYAEKCSSTLAVTYSSGSMDERAIITTDVNHECTEQHSGTSASAPFAAGICALALSANRFLTWRDMQHLVVITARKANLR-AVDWSTNAAGKEYSHSFGFGLMDAGAMVDLA--LNWTTVPEQHICHYVAPMQGGPISLKPYANEVLSITTDACSDNSKKRVRYLEHVQAKISLRSTKRGEVELWLISPSRSTSKLLTKRRNDVASAGFHHWPFMSVHFWGEEAPGTWKLTIYSYDAEV----TLINWSLILYGTDTLPSHRQ 1854
            GA   +E R  YT+ WA+ +NG +++A+ +A  +GF  +  I  +   Y  +H     RS   +      L     V W+EQQ  KVR KR                 DP W   WYL+   K+  ++I  I  WKKG  G+ VVV+ILDDGIE +H DL +NYDPNAS+D+   DN+P PRY  +N     +N HGTRCAG+VAA ANN  CGVGVA+ A IGG+RMLDG V+D VE+ SL L  Q+IDIYSASWGP DDG TV+GPG LA  AF +GI KGR GLGSIFVWASGNGG++ D+CNCDGYT+SI+TL +++ S+ G++PWY+E CSSTLA T+SSG+  E+ I+TTD+++ CTE+H+GTSASAP AAGI ALAL  N  LTWRDMQH+VV T+    L+   DWS N      +  FGFGL+ A  +VD+A    + TVPE+  C     +       K      + +    CS  +   +RYLEHVQ  +SL   +RG++ ++L SP  + S LL+ R+ D ++ GF  WPFM+ H WGE+  GTW L I           TL  W LIL+GT   P+H+Q
Sbjct:   31 GADLSAEERV-YTNGWAIHVNGGIEEAKEVAKAHGFEKVEPIGTLEGYYHLEHPSHPSRSRRSAEDRTDQLRQHRHVTWVEQQHEKVREKRGFYHDRMVARGIVPRFKDPLWDAQWYLDDKRKDTDLDIHVIPVWKKGISGKGVVVTILDDGIEHNHTDLIKNYDPNASWDVNDGDNDPFPRYDPTN-----ENKHGTRCAGEVAAEANNTKCGVGVAFNARIGGVRMLDGRVTDKVEAESLSLNPQYIDIYSASWGPSDDGATVEGPGTLATAAFLNGIQKGRGGLGSIFVWASGNGGRHGDSCNCDGYTDSIYTLSISSASDHGESPWYSESCSSTLATTFSSGAHGEKRIVTTDLHNTCTERHTGTSASAPLAAGIFALALEVNPKLTWRDMQHIVVHTSNHLPLKHDQDWSKNGIDLMVNRKFGFGLLVAEKIVDMANPATYVTVPEKRFCR--GQINQDAKVFKWDKPLTIQLPATGCS-GTGDEIRYLEHVQLMVSLDYVRRGDLVIYLTSPMGTKSCLLSPRKEDSSNEGFSKWPFMTTHSWGEDPRGTWTLEIKDLGDNKANHGTLREWQLILHGTKDKPAHQQ 613

[Close]

BLAST of Furin-1 vs. Ensembl Nematostella
Match: EDO47326 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7RME4])

HSP 1 Score: 493.812 bits (1270), Expect = 5.308e-167
Identity = 273/578 (47.23%), Postives = 364/578 (62.98%), Query Frame = 1

Query:  172 SRGHYTDTWAVQINGTVDDARILAATYGFVFLNEI--MPSIYSFKHRRVSKRSIYPSNYYQSNLSDDPRVIWLEQQFAKVRVKRHIVNDPKWYKMWYLNKMN-----KENSMNIISAWKKGYRGQNVVVSILDDGIEKDHPDLKENYDPNASYDIISNDNNPEPRYISSNNTKIKDNHHGTRCAGQVAATANNRICGVGVAYKANIGGIRMLDGEVSDSVESHSLRLFYQHIDIYSASWGPEDDGKTVDGPGELAKIAFEDGILKGRNGLGSIFVWASGNGGKNHDNCNCDGYTNSIFTLGVNAVSEIGDAPWYAEKCSSTLAVTYSSGSMD--ERAIITTDVNHECTEQHSGTSASAPFAAGICALALSANRFLTWRDMQHLVVITARKANLRAVDWSTNAAGKEYSHSFGFGLMDAGAMVDLALN--WTTVPEQHICHYVAPMQGGPISLKPYANEVLSITTDA--CSDNSKKRVRYLEHVQAKISLRSTKRGEVELWLISPSRSTSKLLTKRRNDVASAGFHHWPFMSVHFWGEEAPGTWKLTIYSYDAEV-TLINWSLILYGTDTLPSHRQNST 1863
            S+  YT+TW +  +   +    LAA +GF    +   +   Y  +H+R SKR      ++ +N   DP V + +QQ    R KR  V DP +   WYLN        K   +N++  W+K   G+NVVV+ILDDGIE  HPDL++NYD  ASYD    D++P PRY   N      N HGTRCAG+VAA  N   CGVGVAY A IGGIRMLDG+V+D VE  SL L   +IDIYS+SWGP+DDG+TVDGPG +AK AF DGI KGR GLGSIFVWA+GNGG+ +D CNCDGY  SI+T+ + A+++ G +PWYAE C STL VTYSSG  +  +  I+TTD++H+CT++H+GTSA+AP AAGI AL L AN  LTWRD+QHLVV T++K +    +W TN AG   ++ +GFG++D+ A+V+LA +  W T  EQH+C       G   S +   N  L++T DA  CS  S    R LEHV+  ++LR  +RG + + LISPS + S LL +R  D ++ GF +WPFM+V  W E   G WKL + ++ +   T   W +  +GT   P  R+N T
Sbjct:   24 SKPLYTNTWVIYTDKGQEYVDNLAAKHGFKSHRDGGGLEGFYILEHQRTSKRMRRSLVHHSTNFLRDPHVSYAKQQKILRRQKRGFV-DPLFNDQWYLNNYGQTPGPKGLDINVLPVWRKNITGKNVVVTILDDGIEYTHPDLQQNYDKEASYDYNHYDSDPFPRYSPDN-----INKHGTRCAGEVAAIKNTH-CGVGVAYNARIGGIRMLDGDVTDIVEGKSLSLKTGYIDIYSSSWGPDDDGRTVDGPGPMAKRAFRDGIKKGRRGLGSIFVWATGNGGRYNDYCNCDGYITSIYTISIGAINDKGKSPWYAENCPSTLGVTYSSGQTNGPDLQIVTTDLHHKCTKEHTGTSAAAPLAAGIFALVLEANPKLTWRDLQHLVVNTSKKTDAGDSEWITNGAGHHVNNKYGFGVLDSAALVELAQSPKWRTAEEQHVCR----EPGSSSSQEIPKNGELTLTLDATGCSGKSNCVTR-LEHVRVYVTLRHDRRGAISIVLISPSGTRSDLLKQRSKDFSNNGFKNWPFMTVFSWNENPVGKWKLVVRNHASTAGTFDRWFIKFFGTCQRP--RKNIT 587

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BLAST of Furin-1 vs. Ensembl Nematostella
Match: EDO32292 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7SVH1])

HSP 1 Score: 480.715 bits (1236), Expect = 2.857e-164
Identity = 245/451 (54.32%), Postives = 310/451 (68.74%), Query Frame = 1

Query:  430 DPKWYKMWYLNKMNKENSMNIISAWKKGYRGQNVVVSILDDGIEKDHPDLKENYDPNASYDIISNDNNPEPRYISSNNTKIKDNHHGTRCAGQVAATANNRICGVGVAYKANIGGIRMLDGEVSDSVESHSLRLFYQHIDIYSASWGPEDDGKTVDGPGELAKIAFEDGILKGRNGLGSIFVWASGNGGKNHDNCNCDGYTNSIFTLGVNAVSEIGDAPWYAEKCSSTLAVTYSSGSMDERAIITTDVNHECTEQHSGTSASAPFAAGICALALSANRFLTWRDMQHLVVITARKANLRAVDWSTNAAGKEYSHSFGFGLMDAGAMVDLALNWTTVPEQHICHYVAPMQGGPISLKPYANEVLSITTDA--CSDNSKKRVRYLEHVQAKISLRSTKRGEVELWLISPSRSTSKLLTKRRNDVASAGFHHWPFMSVHFWGEEAPGTWKLTIY 1776
            DP + + W+L      +  +++  W+ G  G++VVVSILDDGIE  H DLKENYD  ASYD  SND +P PRY  ++     +N HGTRCAG+VAA  NN +CGVGVA KA +GG+RMLDG+V+D+VE+ SL L  QHIDIYSASWGP+DDGKTVDGP  LA+ AF DGI KGR G GSI+VWASGNGG+  DNCNCDGYTNSI+TL +++V+EIG++PWY+E CSSTLA  +SSGS + R I+T DV + CT+ H+GTSASAP AAGI A+AL  NR LTWRDMQH+VV T     L   D  TN  G+  SH+FG+GL+DA  +V LA  W TVP Q +           I  K   +  L++ T+A  C+  + + +RYLEHV+  ISL S KRG++ ++L SP  + S LL KR  D +  GFH W FM+ H W E   GTW L I+
Sbjct:    1 DPLFEEQWHLAGYEAFDH-HVLPVWQMGVYGKDVVVSILDDGIEYTHDDLKENYDKLASYDFNSNDADPAPRYTWND-----ENRHGTRCAGEVAAQMNNSVCGVGVAPKAKVGGVRMLDGDVTDAVEAGSLSLNPQHIDIYSASWGPDDDGKTVDGPARLARKAFTDGIEKGRGGKGSIYVWASGNGGRTSDNCNCDGYTNSIYTLSISSVTEIGNSPWYSEACSSTLASAFSSGSWNNRKIVTVDVRNRCTKTHTGTSASAPLAAGILAMALEVNRNLTWRDMQHIVVRTCTMDKLNMHDVVTNGVGRLVSHTFGYGLLDATRLVKLARVWRTVPPQRVSFLF-------IYRKIPDDGALTVRTEATGCTGTANE-IRYLEHVECIISLDSVKRGDISIYLTSPRGTRSTLLGKRIRDNSQNGFHDWAFMTTHSWEENPTGTWTLEIF 437

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BLAST of Furin-1 vs. Ensembl Nematostella
Match: EDO38851 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7SBU0])

HSP 1 Score: 451.44 bits (1160), Expect = 3.924e-150
Identity = 239/546 (43.77%), Postives = 340/546 (62.27%), Query Frame = 1

Query:  184 YTDTWAVQIN-GTVDDARILAATYGFVFLNEI--MPSIYSFKHRRV----SKRSIYPSNYYQSNLSDDPRVIWLEQQFAKVRVKRHIV-NDPKWYKMWYLNKMNKENS-----MNIISAWKKGYRGQNVVVSILDDGIEKDHPDLKENYDPNASYDIISNDNNPEPRYISSNNTKIKDNHHGTRCAGQVAATANNRICGVGVAYKANIGGIRMLDGEVSDSVESHSLRLFYQHIDIYSASWGPEDDGKTVDGPGELAKIAFEDGILKGRNGLGSIFVWASGNGGKNHDNCNCDGYTNSIFTLGVNAVSEIGDAPWYAEKCSSTLAVTYSSGSMDER---AIITTDVNHECTEQHSGTSASAPFAAGICALALSANRFLTWRDMQHLVVITARKANLRAVDWSTNAAGKEYSHSFGFGLMDAGAMVDLALNWTTVPEQHICHYVAPMQGGPISLKPYANEVLSITTDACSDNSKKRVRYLEHVQAKISLRSTKRGEVELWLISPSRSTSKLLTKRRNDVASAGFHHWPFMSVHFWGEEAPGTWKLTI 1773
            +T++WAVQ++   V+ A  +AA +GF  L ++  +   Y FKH       ++R ++     +  + +D  V+W ++Q    R +++IV +DPK++  WYL    +        ++++ AW +   G+ VVVSILDDG++  HPDL++N+D  ASYD   ND +P+PR   S+     DN HGTRCAG+VAA ANN +CGVGVAY ANIGG+RMLDG+ +D +E  SL     +IDIYS  WGP+DDGKT   PG+LA+ A   G LKGR G G+I+VWA+GNGG   D+CNCDGYT SI+T+ +  + + G + +Y E CSSTL VT++ GS  ER    ++TTD++H+CTE+  GTS++AP AAG+ AL L AN  L+WRD+QHLVV TA+  +     W  N AG  ++H FGFG +DA AMV  A  W +V  Q ICH   P       +       ++I T ACS  + K +  LEHV   +S +  +RG+V + L SPS + +++L+ RR D +  G H W FM+VH WGE   G W + +
Sbjct:    2 FTNSWAVQLDSAEVEAADRIAAKHGFTNLGQVGSLKGYYHFKHVHKPGNRARRELHVHEKTRLLMQED-EVLWAQRQHVLARTRKYIVPHDPKFHDQWYLFNDGQSTGPAGVDIDVVPAWNRNITGRGVVVSILDDGVDHTHPDLRDNFDQKASYDF--NDMDPDPRPRDSD----PDNCHGTRCAGEVAA-ANNDVCGVGVAYNANIGGVRMLDGQATDVLEGSSLSFQSAYIDIYSNCWGPKDDGKTFGKPGKLAQEALMQGALKGRGGRGNIYVWATGNGGLTDDDCNCDGYTTSIYTISIGCIGDHGLSAYYTELCSSTLGVTFNGGSHREREENKMVTTDLHHKCTEEFKGTSSAAPLAAGMIALVLEANPNLSWRDVQHLVVETAQVTSPVDEGWMKNGAGYHFNHKFGFGRLDADAMVKRAKTWKSVAPQRICH--GPSSSTQQEIPTGGTLSITIDTIACS-GTDKMLTKLEHVTLTVSFQHRRRGDVSIDLFSPSGTRNEMLSTRRYDDSKNGLHDWTFMTVHNWGENPKGEWVMNV 536

[Close]

BLAST of Furin-1 vs. Ensembl Nematostella
Match: EDO38852 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7SBU1])

HSP 1 Score: 442.965 bits (1138), Expect = 3.779e-147
Identity = 232/545 (42.57%), Postives = 327/545 (60.00%), Query Frame = 1

Query:  178 GHYTDTWAVQINGTVDD--ARILAATYGFVFLNEI--MPSIYSFKHRRVSKRSIYPSNYYQSNLSDDPRVIWLEQQFAKVRVKRH-IVNDPKWYKMWYLNKMNKENS-----MNIISAWKKGYRGQNVVVSILDDGIEKDHPDLKENYDPNASYDIISNDNNPEPRYISSNNTKIKDNHHGTRCAGQVAATANNRICGVGVAYKANIGGIRMLDGEVSDSVESHSLRLFYQHIDIYSASWGPEDDGKTVDGPGELAKIAFEDGILKGRNGLGSIFVWASGNGGKNHDNCNCDGYTNSIFTLGVNAVSEIGDAPWYAEKCSSTLAVTYSSGS---MDERAIITTDVNHECTEQHSGTSASAPFAAGICALALSANRFLTWRDMQHLVVITARKANLRAVDWSTNAAGKEYSHSFGFGLMDAGAMVDLALNWTTVPEQHICHYVAPMQGGPISLKPYANEVLSITTDACSDNSKKRVRYLEHVQAKISLRSTKRGEVELWLISPSRSTSKLLTKRRNDVASAGFHHWPFMSVHFWGEEAPGTWKLTI 1773
            G++T+TWAV+I    ++   R ++  +GF  + +I  +   Y  +H  V + +   +      L  +  V W EQQ    RV++  I  DP + +MWYL    +        +N+I  WK+G  G+ VVV++LDDG++ +HPDLK NY+P AS+D   ND +P PR I        DN HGTRCAG++AA AN+ ICG GVAY A IGG+RMLDG+ +D++E+ SL    Q  D+YS  WGP+DDGKT   PG LA  A + G  KGR G G+IFVWA+GNGG   D+CNCDGYT SI+T+ +  + + G + +Y E CSSTLAVT++ G+    +E  +ITTD+  +CTEQ  GTS++AP AAG+ AL L  N  LTWRD+QH++V TA+  +     W TN AG  ++H FGFG +DA AMV+ +  W  VP Q  C   + + G    +    +  + I T  C   +   + +LEHV   +S    +RG+V L L SPS + +++L+ RR D +  G   W FM+VH WGE   G WKL +
Sbjct:    3 GYFTNTWAVEIEHPFEEKYVREISKRHGFTIIGKIGNLKGHYHLRHDDVDELNKEHNRDKTDRLLLEDNVRWAEQQKILHRVRKDGIPTDPMFTEMWYLMNTGQTGGPVGVDINVIPVWKRGITGRGVVVTVLDDGMDHNHPDLKPNYEPCASHDFNDNDQDPAPRDIDP------DNCHGTRCAGEIAAVANDSICGAGVAYNAKIGGVRMLDGKATDALEACSLGFANQVTDVYSNCWGPKDDGKTFGKPGPLAAKALKSGAEKGRGGKGNIFVWATGNGGLTDDDCNCDGYTTSIYTVSIGCIGDHGLSAYYTELCSSTLAVTFNGGAHREKEENKMITTDLKGKCTEQFKGTSSAAPLAAGMVALMLEQNPSLTWRDVQHIIVHTAKMTSPVDDGWRTNGAGLHFNHKFGFGRLDADAMVEKSRVWKNVPVQRTCTGASSVTGDEKDIPVGGSLDIQIPTGGCM-GTIAEINHLEHVVLTVSFIHRRRGDVSLLLTSPSGTKNEMLSTRRYDDSKEGLDKWSFMTVHCWGENPRGFWKLNV 540

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BLAST of Furin-1 vs. Ensembl Medaka
Match: furina (furin-1 [Source:NCBI gene;Acc:100049240])

HSP 1 Score: 581.637 bits (1498), Expect = 0.000e+0
Identity = 301/585 (51.45%), Postives = 391/585 (66.84%), Query Frame = 1

Query:   97 EYIVMKCFVILFSSL---FCFGAKSQSESRGHYTDTWAVQINGTVDDARILAATYGFVFLNEIMPSIYSFKHRRVSKRSIYPSNYYQSNLSDDPRVIWLEQQFAKVRVKRHIVN---DPKWYKMWYLNKMNKENSMNIISAWKKGYRGQNVVVSILDDGIEKDHPDLKENYDPNASYDIISNDNNPEPRYISSNNTKIKDNHHGTRCAGQVAATANNRICGVGVAYKANIGGIRMLDGEVSDSVESHSLRLFYQHIDIYSASWGPEDDGKTVDGPGELAKIAFEDGILKGRNGLGSIFVWASGNGGKNHDNCNCDGYTNSIFTLGVNAVSEIGDAPWYAEKCSSTLAVTYSSGSMDERAIITTDVNHECTEQHSGTSASAPFAAGICALALSANRFLTWRDMQHLVVITARKANLRAVDWSTNAAGKEYSHSFGFGLMDAGAMVDLALNWTTVPEQHICHYVAPMQGGPISLKPYANEVLSITTDACSDNSKKRVRYLEHVQAKISLRSTKRGEVELWLISPSRSTSKLLTKRRNDVASAGFHHWPFMSVHFWGEEAPGTWKLTIYSYDAEV---TLINWSLILY 1824
            E++     ++L S +   FC         +  YT+TWAV I G  ++A  +A  +GF+    +    Y F+HR V+KRS+      +  L  DP V W EQQ  K R+KR + N   DPK+   WYL+  N  + +N  +AW++GY G+ VVVSILDDGIEK+HPDL +NYDP+ASYD+   D +P+PRY     T++ DN HGTRCAG+VAA A+N ICGVGVAY A IGG+RMLDGEV+D VE+ SL L  QHI IYSASWGPEDDGKTVDGP +LAK AF  G+ +GR GLGSIFVWASGNGG+  D+CNCDGYTNSI+TL +++ ++ G+ PWY+E CSSTLA TYSSG+++E+ I+TTD+  +CT+ H+GTSASAP AAGI ALAL AN+ LTWRDMQHLVV T+  A+L A DW TN  G++ SHS+G+GL+DAGA+V LA NWT V  Q  C      +   I    Y N+    + DAC   S   V  LEHVQA+++L   +RG + + LISP+ + S LL  R +D +S GF+ W FM+ H W E   GTW+L I +        TL  + L+LY
Sbjct:   18 EFVTGAVLLMLVSGIGPTFC---------QNIYTNTWAVHIPGGQEEADRVAEKHGFINYGHVFSDYYHFRHRTVAKRSLSDHRGTKVRLLRDPMVSWAEQQVVKRRIKRDLFNEPLDPKFKDQWYLSNSNHRD-LNAKAAWQQGYTGKGVVVSILDDGIEKNHPDLMQNYDPDASYDVNDGDPDPQPRY-----TQLNDNRHGTRCAGEVAAAASNGICGVGVAYNAKIGGVRMLDGEVTDMVEAQSLSLNPQHIHIYSASWGPEDDGKTVDGPAKLAKEAFLRGVTEGRGGLGSIFVWASGNGGREKDSCNCDGYTNSIYTLSISSSTQNGNVPWYSEACSSTLATTYSSGNINEKQIVTTDLKSKCTDSHTGTSASAPLAAGIIALALEANQNLTWRDMQHLVVQTSHPAHLLANDWRTNGVGRKVSHSYGYGLLDAGAIVSLAKNWTNVKPQRKCVITMLSEPRNIGNHLYINK----SVDACI-GSDSYVTSLEHVQARLTLSYNRRGNLAIHLISPAGTRSTLLHPRPHDYSSEGFNDWAFMTTHSWDENPTGTWRLEIENVVGASDYGTLTQFVLVLY 582

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BLAST of Furin-1 vs. Ensembl Medaka
Match: pcsk6 (proprotein convertase subtilisin/kexin type 6 [Source:NCBI gene;Acc:101166930])

HSP 1 Score: 573.163 bits (1476), Expect = 0.000e+0
Identity = 296/576 (51.39%), Postives = 382/576 (66.32%), Query Frame = 1

Query:  166 SESRGHYTDTWAVQINGTVDDARILAATYGFVFLNEI--MPSIYSFKHRRVSKRSIYPSNYYQSNLSDDPRVIWLEQQFAKVRVKRHI--------VNDPKWYKMWYLNKMNK----ENSMNIISAWKKGYRGQNVVVSILDDGIEKDHPDLKENYDPNASYDIISNDNNPEPRYISSNNTKIKDNHHGTRCAGQVAATANNRICGVGVAYKANIGGIRMLDGEVSDSVESHSLRLFYQHIDIYSASWGPEDDGKTVDGPGELAKIAFEDGILKGRNGLGSIFVWASGNGGKNHDNCNCDGYTNSIFTLGVNAVSEIGDAPWYAEKCSSTLAVTYSSGSMDERAIITTDVNHECTEQHSGTSASAPFAAGICALALSANRFLTWRDMQHLVVITARKANLRAVDWSTNAAGKEYSHSFGFGLMDAGAMVDLALNWTTVPEQHICHYVAPMQGGPISLKPYANEVLSITTDACSDNSKKRVRYLEHVQAKISLRSTKRGEVELWLISPSRSTSKLLTKRRNDVASAGFHHWPFMSVHFWGEEAPGTWKLTIYSYDAEV-------TLINWSLILYGT 1830
            S  R  YT+ WAVQI G  D A  +AA YG+  L +I  +  +Y F H RV +R+  P     S +  D +V W +QQ  K RVKR           NDPKW  MWY+N  +      + MN+++AW++GY G+NVVVSILDDGIE++HPDL +NYD  ASYDI  ND++P PRY S N     +N HGTRCAG+VAA ANN  C VG+AY A+IGGIRMLDG+V+D VE+ SL +   +I IYSASWGP+DDG+TVDGPG L + AFE GI KGR GLGSIFVWA+GNGG+  D+C+CDGYT+SI+T+ V++ +E G+ PWY E CSS +  TYSSG   ER I+TTD+   CT+ H+GTS SAP  AG+ ALAL AN  L+WRD+QHL+V T+R A+L+A DW TNAAG   SH +GFGL+DA AMV  A  W  VP QH C  V+  +   I      N   SITT  CS + ++ V++LEHV  K+ L   +RG++E+ LISP+ + S+LL +R  D +S GF +W FM+VHFW E   GTW L +    +++        L  W+LILYGT
Sbjct:   43 SGRRDRYTNHWAVQILGGPDQADAVAAKYGYRNLGQIGGLQDLYHFHHSRVVRRATLPHRGPHSLIHLDAQVAWAQQQLVKPRVKRIAQTDPAFLGFNDPKWSSMWYINCQDDGGRCRSDMNVLAAWQRGYTGRNVVVSILDDGIERNHPDLSQNYDHLASYDINGNDHDPTPRYDSRN-----ENVHGTRCAGEVAAAANNSQCIVGIAYNAHIGGIRMLDGDVTDIVEAKSLGIRPDYIHIYSASWGPKDDGRTVDGPGPLTRQAFERGIQKGRRGLGSIFVWAAGNGGRQADHCSCDGYTSSIYTISVSSTTENGNRPWYLEVCSSIMVTTYSSGEFHERKIVTTDLWQRCTDAHTGTSISAPIVAGVIALALEANFLLSWRDVQHLLVKTSRPAHLKAEDWKTNAAGLTVSHLYGFGLVDADAMVMEARRWRPVPPQHTCSQVSGRRSRHIHAGLRLNS--SITTSGCSGDPQQHVQHLEHVVVKVLLLHPRRGDLEMELISPAGTRSQLLARRLLDSSSEGFRNWEFMTVHFWAETPNGTWTLEVKDTPSKLRNLEVLGNLKEWTLILYGT 611

[Close]

BLAST of Furin-1 vs. Ensembl Medaka
Match: furinb (furin, paired basic amino acid cleaving enzyme [Source:NCBI gene;Acc:101158353])

HSP 1 Score: 568.155 bits (1463), Expect = 0.000e+0
Identity = 295/582 (50.69%), Postives = 385/582 (66.15%), Query Frame = 1

Query:  109 MKCFVILFSSLFCFGAKSQSESRGHYTDTWAVQINGTVDDARILAATYGFVFLNEIMPSIYSFKHRRVSKRSIYPSNYYQSNLSDDPRVIWLEQQFAKVRVKRHIV---NDPKWYKMWYLNKMNKENSMNIISAWKKGYRGQNVVVSILDDGIEKDHPDLKENYDPNASYDIISNDNNPEPRYISSNNTKIKDNHHGTRCAGQVAATANNRICGVGVAYKANIGGIRMLDGEVSDSVESHSLRLFYQHIDIYSASWGPEDDGKTVDGPGELAKIAFEDGILKGRNGLGSIFVWASGNGGKNHDNCNCDGYTNSIFTLGVNAVSEIGDAPWYAEKCSSTLAVTYSSGSMDERAIITTDVNHECTEQHSGTSASAPFAAGICALALSANRFLTWRDMQHLVVITARKANLRAVDWSTNAAGKEYSHSFGFGLMDAGAMVDLALNWTTVPEQHICHYVAPMQGGPISLKPYANEVLSITTDACSDNSKKRVRYLEHVQAKISLRSTKRGEVELWLISPSRSTSKLLTKRRNDVASAGFHHWPFMSVHFWGEEAPGTWKLTIYS-----YDAEVTLINWSLILYGT 1830
            M  +V L  +   F     +++   YT++WAVQI+G  ++A  +A  +GF+    +    Y F+H  V +RS+         L ++P+++W EQQ  K R KR I     DP + K WYL+    ++ ++  +AW +GY G+ VVV+ILDDGIEKDHPDL  NYDP ASYD+   D +P+PRY   N     +N HGTRCAG+VAA ANN +CGVGVAY A IGG+RMLDGEV+D VE+ SL L  QHI IYSASWGPEDDGK++DGP +LAK AF  GI KGR+GLGSIFVWASGNGG+  D+CNCDGYTNSI+TL +++ ++ G  PWY+E CSSTLA T+SSG+  E+ I+TTD+  +CT+ H+GTSASAP AAGI ALAL AN  LTWRDMQHLVV T++  +L A DW TN  G+  SHS+G+GL+DA AMV LA NWTTV  QH C +    +   I  K     V S + DAC       V  LEHVQA+++L   +RG++ + LISP  + S LL  R ND +S GF+ W FM+ H W E+  G W L I +     +D  V L  ++L+L+GT
Sbjct:    1 MDAWVALLLTWTGFVLLKWTDAAEVYTNSWAVQISGGPEEADRIAREHGFINHGNVFGDYYHFRHHAVKRRSLSIHKGMHIKLQEEPKILWAEQQVVKKRKKRDIYEDPTDPDFPKQWYLSNPTHQD-LDTKAAWAQGYTGRGVVVTILDDGIEKDHPDLISNYDPEASYDVNDGDADPQPRYTQRN-----ENRHGTRCAGEVAAAANNGVCGVGVAYHAKIGGVRMLDGEVTDVVEARSLSLNPQHIHIYSASWGPEDDGKSLDGPAKLAKEAFIQGITKGRSGLGSIFVWASGNGGREQDSCNCDGYTNSIYTLSISSTTQSGSVPWYSEPCSSTLATTFSSGNPGEKQIVTTDLRQKCTDSHTGTSASAPLAAGIIALALEANMNLTWRDMQHLVVRTSQPGHLSAADWKTNGVGRTVSHSYGYGLLDAAAMVGLAQNWTTVGPQHQCVHTMLAEPRDIGNK----LVFSKSLDACW-GRPDYVSSLEHVQARLTLSHNQRGKLAVHLISPLGTRSTLLFPRPNDYSSEGFNDWAFMTTHSWDEDPQGEWTLEIENVAPNGHDYGV-LTQFTLLLWGT 570

[Close]

BLAST of Furin-1 vs. Ensembl Medaka
Match: furinb (furin, paired basic amino acid cleaving enzyme [Source:NCBI gene;Acc:101158353])

HSP 1 Score: 546.584 bits (1407), Expect = 0.000e+0
Identity = 282/546 (51.65%), Postives = 364/546 (66.67%), Query Frame = 1

Query:  235 ILAATYGFVFL------NEIMPSIYSFKHRRVSKRSIYPSNYYQSNLSDDPRVIWLEQQFAKVRVKRHIV---NDPKWYKMWYLNKMNKENSMNIISAWKKGYRGQNVVVSILDDGIEKDHPDLKENYDPNASYDIISNDNNPEPRYISSNNTKIKDNHHGTRCAGQVAATANNRICGVGVAYKANIGGIRMLDGEVSDSVESHSLRLFYQHIDIYSASWGPEDDGKTVDGPGELAKIAFEDGILKGRNGLGSIFVWASGNGGKNHDNCNCDGYTNSIFTLGVNAVSEIGDAPWYAEKCSSTLAVTYSSGSMDERAIITTDVNHECTEQHSGTSASAPFAAGICALALSANRFLTWRDMQHLVVITARKANLRAVDWSTNAAGKEYSHSFGFGLMDAGAMVDLALNWTTVPEQHICHYVAPMQGGPISLKPYANEVLSITTDACSDNSKKRVRYLEHVQAKISLRSTKRGEVELWLISPSRSTSKLLTKRRNDVASAGFHHWPFMSVHFWGEEAPGTWKLTIYS-----YDAEVTLINWSLILYGT 1830
            +L +T   +F+       ++    Y F+H  V +RS+         L ++P+++W EQQ  K R KR I     DP + K WYL+    ++ ++  +AW +GY G+ VVV+ILDDGIEKDHPDL  NYDP ASYD+   D +P+PRY   N     +N HGTRCAG+VAA ANN +CGVGVAY A IGG+RMLDGEV+D VE+ SL L  QHI IYSASWGPEDDGK++DGP +LAK AF  GI KGR+GLGSIFVWASGNGG+  D+CNCDGYTNSI+TL +++ ++ G  PWY+E CSSTLA T+SSG+  E+ I+TTD+  +CT+ H+GTSASAP AAGI ALAL AN  LTWRDMQHLVV T++  +L A DW TN  G+  SHS+G+GL+DA AMV LA NWTTV  QH C +    +   I  K     V S + DAC       V  LEHVQA+++L   +RG++ + LISP  + S LL  R ND +S GF+ W FM+ H W E+  G W L I +     +D  V L  ++L+L+GT
Sbjct:   33 VLPSTTSLLFILRSSGPVKVFGDYYHFRHHAVKRRSLSIHKGMHIKLQEEPKILWAEQQVVKKRKKRDIYEDPTDPDFPKQWYLSNPTHQD-LDTKAAWAQGYTGRGVVVTILDDGIEKDHPDLISNYDPEASYDVNDGDADPQPRYTQRN-----ENRHGTRCAGEVAAAANNGVCGVGVAYHAKIGGVRMLDGEVTDVVEARSLSLNPQHIHIYSASWGPEDDGKSLDGPAKLAKEAFIQGITKGRSGLGSIFVWASGNGGREQDSCNCDGYTNSIYTLSISSTTQSGSVPWYSEPCSSTLATTFSSGNPGEKQIVTTDLRQKCTDSHTGTSASAPLAAGIIALALEANMNLTWRDMQHLVVRTSQPGHLSAADWKTNGVGRTVSHSYGYGLLDAAAMVGLAQNWTTVGPQHQCVHTMLAEPRDIGNK----LVFSKSLDACW-GRPDYVSSLEHVQARLTLSHNQRGKLAVHLISPLGTRSTLLFPRPNDYSSEGFNDWAFMTTHSWDEDPQGEWTLEIENVAPNGHDYGV-LTQFTLLLWGT 566

[Close]

BLAST of Furin-1 vs. Ensembl Medaka
Match: pcsk5b (proprotein convertase subtilisin/kexin type 5 [Source:NCBI gene;Acc:101170192])

HSP 1 Score: 530.02 bits (1364), Expect = 1.728e-176
Identity = 300/588 (51.02%), Postives = 378/588 (64.29%), Query Frame = 1

Query:  184 YTDTWAVQINGTVDDARILAATYGFVFLNEI--MPSIYSFKHRRVSKRSIYPSNYYQSNLSDDPRVIWLEQQFAKVRVKRH----------------------IVNDPKWYKMWYL----NKMNKENSMNIISAWKKGYRGQNVVVSILDDGIEKDHPDLKENYDPNASYDIISNDNNPEPRYISSNNTKIKDNHHGTRCAGQVAATANNRICGVGVAYKANIGGIRMLDGEVSDSVESHSLRLFYQHIDIYSASWGPEDDGKTVDGPGELAKIAFEDGILKGRNGLGSIFVWASGNGGKNHDNCNCDGYTNSIFTLGVNAVSEIGDAPWYAEKCSSTLAVTYSSGSMDERAIITTDVNHECTEQHSGTSASAPFAAGICALALSANRFLTWRDMQHLVVITARKANLRAVDWSTNAAGKEYSHSFGFGLMDAGAMVDLALNWTTVPEQHICHYVAPMQGGPISLKPYANEVLSITTDACSDNSKKRVRYLEHVQAKISLRSTKRGEVELWLISPSRSTSKLLTKRRNDVASAGFHHWPFMSVHFWGEEAPGTWKLTIYSYDAEV-------TLINWSLILYGTDTLP 1842
            YT+ WAV+I G  D A  +AA YG+  + +I  +   Y F H R  KRS   S    S +S +P+V W+EQQ  K R+KR                         ND KW  MWY+    +  N ++ MNI+ AWK+G+ G+ VVV+ILDDGIE++HPDL  NYDP ASYD+ SND +P PRY ++N     +N HGTRCAG+VAA ANN  C VG+AY A IGG+RMLDG+V+D VE+ SL L  QHIDIYSASWGP+DDGKTVDGP  LA+ AFE+GI  GR G GSIFVWASGNGG++ D+C+CDGYTNSI+T+ +++ +E G  PWY E+CSSTL  TYSSG   +R IITTD+ H CT+ H+GTSASAP AA I ALAL AN  LTWRD+QH++V T+R  +L A DW TNAAG   SH +GFGLMDA AMV  A  W  VP QHIC   A  Q   I  +     V   T   C+DN  + V YLEHV  +I++   +RG++ + L SPS + S+LL  R  D +  GF +W FM+ H WGE+A G W L IY   +++        L  WSL+LYGT   P
Sbjct:   31 YTNHWAVRIAGGPDVADRIAAKYGYRNMGQIGDLKDHYHFFHSRTIKRSTLSSRGRHSFISMEPKVEWIEQQVVKRRIKRDYKPVPPHSLTSPAYSNQAQNNIFYNDAKWSSMWYIHCNGDVHNCQSDMNIMGAWKRGFTGKGVVVTILDDGIERNHPDLSYNYDPQASYDVNSNDPDPMPRYDATN-----ENKHGTRCAGEVAAAANNSHCIVGIAYNAKIGGVRMLDGDVTDMVEARSLSLHPQHIDIYSASWGPDDDGKTVDGPASLARQAFENGIRSGRKGRGSIFVWASGNGGRSRDHCSCDGYTNSIYTISISSTAESGRKPWYLEECSSTLTTTYSSGENYDRKIITTDLRHRCTDSHTGTSASAPMAAAIIALALEANSDLTWRDVQHIIVKTSRAGHLSAPDWKTNAAGYNVSHLYGFGLMDAEAMVKEAERWKHVPAQHICVESADRQIRTIRPEHVVRSVYKAT--GCADNPNQHVIYLEHVVVRITITHPRRGDLSINLTSPSGTKSQLLANRLFDHSMEGFKNWEFMTTHCWGEKAAGDWVLEIYDSPSQLRSQKVPGKLKEWSLVLYGTSVNP 611

[Close]

BLAST of Furin-1 vs. Planmine SMEST
Match: SMESG000049794.1 (SMESG000049794.1)

HSP 1 Score: 1349.73 bits (3492), Expect = 0.000e+0
Identity = 645/645 (100.00%), Postives = 645/645 (100.00%), Query Frame = 1

Query:  109 MKCFVILFSSLFCFGAKSQSESRGHYTDTWAVQINGTVDDARILAATYGFVFLNEIMPSIYSFKHRRVSKRSIYPSNYYQSNLSDDPRVIWLEQQFAKVRVKRHIVNDPKWYKMWYLNKMNKENSMNIISAWKKGYRGQNVVVSILDDGIEKDHPDLKENYDPNASYDIISNDNNPEPRYISSNNTKIKDNHHGTRCAGQVAATANNRICGVGVAYKANIGGIRMLDGEVSDSVESHSLRLFYQHIDIYSASWGPEDDGKTVDGPGELAKIAFEDGILKGRNGLGSIFVWASGNGGKNHDNCNCDGYTNSIFTLGVNAVSEIGDAPWYAEKCSSTLAVTYSSGSMDERAIITTDVNHECTEQHSGTSASAPFAAGICALALSANRFLTWRDMQHLVVITARKANLRAVDWSTNAAGKEYSHSFGFGLMDAGAMVDLALNWTTVPEQHICHYVAPMQGGPISLKPYANEVLSITTDACSDNSKKRVRYLEHVQAKISLRSTKRGEVELWLISPSRSTSKLLTKRRNDVASAGFHHWPFMSVHFWGEEAPGTWKLTIYSYDAEVTLINWSLILYGTDTLPSHRQNSTHTKSQKRPPKNVPYINNNNERNLETSFEVKENQIIFPQSSHSLRFSFKLIFISVLLIGYR 2043
            MKCFVILFSSLFCFGAKSQSESRGHYTDTWAVQINGTVDDARILAATYGFVFLNEIMPSIYSFKHRRVSKRSIYPSNYYQSNLSDDPRVIWLEQQFAKVRVKRHIVNDPKWYKMWYLNKMNKENSMNIISAWKKGYRGQNVVVSILDDGIEKDHPDLKENYDPNASYDIISNDNNPEPRYISSNNTKIKDNHHGTRCAGQVAATANNRICGVGVAYKANIGGIRMLDGEVSDSVESHSLRLFYQHIDIYSASWGPEDDGKTVDGPGELAKIAFEDGILKGRNGLGSIFVWASGNGGKNHDNCNCDGYTNSIFTLGVNAVSEIGDAPWYAEKCSSTLAVTYSSGSMDERAIITTDVNHECTEQHSGTSASAPFAAGICALALSANRFLTWRDMQHLVVITARKANLRAVDWSTNAAGKEYSHSFGFGLMDAGAMVDLALNWTTVPEQHICHYVAPMQGGPISLKPYANEVLSITTDACSDNSKKRVRYLEHVQAKISLRSTKRGEVELWLISPSRSTSKLLTKRRNDVASAGFHHWPFMSVHFWGEEAPGTWKLTIYSYDAEVTLINWSLILYGTDTLPSHRQNSTHTKSQKRPPKNVPYINNNNERNLETSFEVKENQIIFPQSSHSLRFSFKLIFISVLLIGYR
Sbjct:    1 MKCFVILFSSLFCFGAKSQSESRGHYTDTWAVQINGTVDDARILAATYGFVFLNEIMPSIYSFKHRRVSKRSIYPSNYYQSNLSDDPRVIWLEQQFAKVRVKRHIVNDPKWYKMWYLNKMNKENSMNIISAWKKGYRGQNVVVSILDDGIEKDHPDLKENYDPNASYDIISNDNNPEPRYISSNNTKIKDNHHGTRCAGQVAATANNRICGVGVAYKANIGGIRMLDGEVSDSVESHSLRLFYQHIDIYSASWGPEDDGKTVDGPGELAKIAFEDGILKGRNGLGSIFVWASGNGGKNHDNCNCDGYTNSIFTLGVNAVSEIGDAPWYAEKCSSTLAVTYSSGSMDERAIITTDVNHECTEQHSGTSASAPFAAGICALALSANRFLTWRDMQHLVVITARKANLRAVDWSTNAAGKEYSHSFGFGLMDAGAMVDLALNWTTVPEQHICHYVAPMQGGPISLKPYANEVLSITTDACSDNSKKRVRYLEHVQAKISLRSTKRGEVELWLISPSRSTSKLLTKRRNDVASAGFHHWPFMSVHFWGEEAPGTWKLTIYSYDAEVTLINWSLILYGTDTLPSHRQNSTHTKSQKRPPKNVPYINNNNERNLETSFEVKENQIIFPQSSHSLRFSFKLIFISVLLIGYR 645

[Close]

BLAST of Furin-1 vs. Planmine SMEST
Match: SMESG000018546.1 (SMESG000018546.1)

HSP 1 Score: 440.654 bits (1132), Expect = 1.786e-146
Identity = 238/490 (48.57%), Postives = 319/490 (65.10%), Query Frame = 1

Query:  403 VRVKRHIVNDPKWYKMWYLNKMN---KENSMNIISAWKKGYRGQNVVVSILDDGIEKDHPDLKENYDPNASYDIISNDNNPEPRYISSNNTKIKDNHHGTRCAGQVAATANNRICGVGVAYKANIGGIRMLDGEVSDSVESHSLRLFYQHIDIYSASWGPEDDGKTVDGPGELAKIAFEDGILKGRNGLGSIFVWASGNGGKNHDNCNCDGYTNSIFTLGVNAVSEIGDAPWYAEKCSSTLAVTYSSGSMDERAIITTDVNHECTEQHSGTSASAPFAAGICALALSANRFLTWRDMQHLVVITARKANLRAVDWSTNAAGKEYSHSFGFGLMDAGAMVDLALNWTTVPEQHICHYVAPMQGGPISLKPYANEVLSITTDACSDNSKKRVRYLEHVQAKISLRSTKRGEVELWLISPSRSTSKLLTKRRNDVAS--AGFHHWPFMSVHFWGEEAPGTWKLTIYSYDAEVTLIN--WS---LILYGTDTLP 1842
            +++K+   +DP + K WYL +     K   MN+  AW+ GY G+ V +SILDDGI+  H DLKENYDP AS+DI  +DN+P P      N K  +N HGTRCAG+V+A ANN  CGVG+AY + IG +RMLDG+V+D VE+ +L    QHIDIYS SWGP+D+G+ V+GP  LAK AF+ GI  GRNGLG+I+VWASGNGGK  D+C CDGY +SI+T+ +++VSE    PWY E C+STLA TYSSG   E+ II+TD+N++C   H+GTSASAP AAGI AL + AN  LTWRD+Q+++V+T+        ++  N A K+ S+ +GFGLMD+G +V +   W  +P  H C       G  ISLK      LS+ TD C    K +V Y+EHV   + L   KRG++ + LISPS + S++L  R +D A   + F  WP MSV FWGE+A G W + I +Y  + +  N  WS   L +YGT+  P
Sbjct:    1 MKIKQIKFSDPLFKKQWYLIRSQFNTKLVDMNVKEAWELGYTGKGVTISILDDGIDYRHDDLKENYDPEASFDINGDDNDPLP------NLKSTENRHGTRCAGEVSAKANNSKCGVGIAYNSRIGAVRMLDGDVTDRVEAEALSFKQQHIDIYSGSWGPDDNGQKVEGPAILAKSAFKKGIRYGRNGLGNIYVWASGNGGKKSDSCACDGYASSIYTISISSVSENNRKPWYLESCASTLASTYSSGDGYEQKIISTDLNNKCAFDHTGTSASAPLAAGIIALLIEANSNLTWRDVQYIIVLTSNPHPFIDGNFIVNGANKKVSNLYGFGLMDSGKLVRIGRLWHKLPSHHFCK--ISYNGKKISLKDKFTVKLSVKTDGCP--GKNKVNYVEHVILYLKLDYDKRGDLRIILISPSGTRSEILPYRPHDFARGPSTFDIWPLMSVQFWGEKASGEWSVEINNYGTKFSKSNGVWSNFELKIYGTEKWP 480

[Close]

BLAST of Furin-1 vs. Planmine SMEST
Match: SMESG000018546.1 (SMESG000018546.1)

HSP 1 Score: 430.639 bits (1106), Expect = 5.619e-143
Identity = 230/460 (50.00%), Postives = 304/460 (66.09%), Query Frame = 1

Query:  484 MNIISAWKKGYRGQNVVVSILDDGIEKDHPDLKENYDPNASYDIISNDNNPEPRYISSNNTKIKDNHHGTRCAGQVAATANNRICGVGVAYKANIGGIRMLDGEVSDSVESHSLRLFYQHIDIYSASWGPEDDGKTVDGPGELAKIAFEDGILKGRNGLGSIFVWASGNGGKNHDNCNCDGYTNSIFTLGVNAVSEIGDAPWYAEKCSSTLAVTYSSGSMDERAIITTDVNHECTEQHSGTSASAPFAAGICALALSANRFLTWRDMQHLVVITARKANLRAVDWSTNAAGKEYSHSFGFGLMDAGAMVDLALNWTTVPEQHICHYVAPMQGGPISLKPYANEVLSITTDACSDNSKKRVRYLEHVQAKISLRSTKRGEVELWLISPSRSTSKLLTKRRNDVAS--AGFHHWPFMSVHFWGEEAPGTWKLTIYSYDAEVTLIN--WS---LILYGTDTLP 1842
            MN+  AW+ GY G+ V +SILDDGI+  H DLKENYDP AS+DI  +DN+P P      N K  +N HGTRCAG+V+A ANN  CGVG+AY + IG +RMLDG+V+D VE+ +L    QHIDIYS SWGP+D+G+ V+GP  LAK AF+ GI  GRNGLG+I+VWASGNGGK  D+C CDGY +SI+T+ +++VSE    PWY E C+STLA TYSSG   E+ II+TD+N++C   H+GTSASAP AAGI AL + AN  LTWRD+Q+++V+T+        ++  N A K+ S+ +GFGLMD+G +V +   W  +P  H C       G  ISLK      LS+ TD C    K +V Y+EHV   + L   KRG++ + LISPS + S++L  R +D A   + F  WP MSV FWGE+A G W + I +Y  + +  N  WS   L +YGT+  P
Sbjct:    1 MNVKEAWELGYTGKGVTISILDDGIDYRHDDLKENYDPEASFDINGDDNDPLP------NLKSTENRHGTRCAGEVSAKANNSKCGVGIAYNSRIGAVRMLDGDVTDRVEAEALSFKQQHIDIYSGSWGPDDNGQKVEGPAILAKSAFKKGIRYGRNGLGNIYVWASGNGGKKSDSCACDGYASSIYTISISSVSENNRKPWYLESCASTLASTYSSGDGYEQKIISTDLNNKCAFDHTGTSASAPLAAGIIALLIEANSNLTWRDVQYIIVLTSNPHPFIDGNFIVNGANKKVSNLYGFGLMDSGKLVRIGRLWHKLPSHHFCK--ISYNGKKISLKDKFTVKLSVKTDGCP--GKNKVNYVEHVILYLKLDYDKRGDLRIILISPSGTRSEILPYRPHDFARGPSTFDIWPLMSVQFWGEKASGEWSVEINNYGTKFSKSNGVWSNFELKIYGTEKWP 450

[Close]

BLAST of Furin-1 vs. Planmine SMEST
Match: SMESG000018546.1 (SMESG000018546.1)

HSP 1 Score: 429.869 bits (1104), Expect = 1.017e-142
Identity = 230/460 (50.00%), Postives = 304/460 (66.09%), Query Frame = 1

Query:  484 MNIISAWKKGYRGQNVVVSILDDGIEKDHPDLKENYDPNASYDIISNDNNPEPRYISSNNTKIKDNHHGTRCAGQVAATANNRICGVGVAYKANIGGIRMLDGEVSDSVESHSLRLFYQHIDIYSASWGPEDDGKTVDGPGELAKIAFEDGILKGRNGLGSIFVWASGNGGKNHDNCNCDGYTNSIFTLGVNAVSEIGDAPWYAEKCSSTLAVTYSSGSMDERAIITTDVNHECTEQHSGTSASAPFAAGICALALSANRFLTWRDMQHLVVITARKANLRAVDWSTNAAGKEYSHSFGFGLMDAGAMVDLALNWTTVPEQHICHYVAPMQGGPISLKPYANEVLSITTDACSDNSKKRVRYLEHVQAKISLRSTKRGEVELWLISPSRSTSKLLTKRRNDVAS--AGFHHWPFMSVHFWGEEAPGTWKLTIYSYDAEVTLIN--WS---LILYGTDTLP 1842
            MN+  AW+ GY G+ V +SILDDGI+  H DLKENYDP AS+DI  +DN+P P      N K  +N HGTRCAG+V+A ANN  CGVG+AY + IG +RMLDG+V+D VE+ +L    QHIDIYS SWGP+D+G+ V+GP  LAK AF+ GI  GRNGLG+I+VWASGNGGK  D+C CDGY +SI+T+ +++VSE    PWY E C+STLA TYSSG   E+ II+TD+N++C   H+GTSASAP AAGI AL + AN  LTWRD+Q+++V+T+        ++  N A K+ S+ +GFGLMD+G +V +   W  +P  H C       G  ISLK      LS+ TD C    K +V Y+EHV   + L   KRG++ + LISPS + S++L  R +D A   + F  WP MSV FWGE+A G W + I +Y  + +  N  WS   L +YGT+  P
Sbjct:    1 MNVKEAWELGYTGKGVTISILDDGIDYRHDDLKENYDPEASFDINGDDNDPLP------NLKSTENRHGTRCAGEVSAKANNSKCGVGIAYNSRIGAVRMLDGDVTDRVEAEALSFKQQHIDIYSGSWGPDDNGQKVEGPAILAKSAFKKGIRYGRNGLGNIYVWASGNGGKKSDSCACDGYASSIYTISISSVSENNRKPWYLESCASTLASTYSSGDGYEQKIISTDLNNKCAFDHTGTSASAPLAAGIIALLIEANSNLTWRDVQYIIVLTSNPHPFIDGNFIVNGANKKVSNLYGFGLMDSGKLVRIGRLWHKLPSHHFCK--ISYNGKKISLKDKFTVKLSVKTDGCP--GKNKVNYVEHVILYLKLDYDKRGDLRIILISPSGTRSEILPYRPHDFARGPSTFDIWPLMSVQFWGEKASGEWSVEINNYGTKFSKSNGVWSNFELKIYGTEKWP 450

[Close]

BLAST of Furin-1 vs. Planmine SMEST
Match: SMESG000018546.1 (SMESG000018546.1)

HSP 1 Score: 439.499 bits (1129), Expect = 3.863e-139
Identity = 238/490 (48.57%), Postives = 319/490 (65.10%), Query Frame = 1

Query:  403 VRVKRHIVNDPKWYKMWYLNKMN---KENSMNIISAWKKGYRGQNVVVSILDDGIEKDHPDLKENYDPNASYDIISNDNNPEPRYISSNNTKIKDNHHGTRCAGQVAATANNRICGVGVAYKANIGGIRMLDGEVSDSVESHSLRLFYQHIDIYSASWGPEDDGKTVDGPGELAKIAFEDGILKGRNGLGSIFVWASGNGGKNHDNCNCDGYTNSIFTLGVNAVSEIGDAPWYAEKCSSTLAVTYSSGSMDERAIITTDVNHECTEQHSGTSASAPFAAGICALALSANRFLTWRDMQHLVVITARKANLRAVDWSTNAAGKEYSHSFGFGLMDAGAMVDLALNWTTVPEQHICHYVAPMQGGPISLKPYANEVLSITTDACSDNSKKRVRYLEHVQAKISLRSTKRGEVELWLISPSRSTSKLLTKRRNDVAS--AGFHHWPFMSVHFWGEEAPGTWKLTIYSYDAEVTLIN--WS---LILYGTDTLP 1842
            +++K+   +DP + K WYL +     K   MN+  AW+ GY G+ V +SILDDGI+  H DLKENYDP AS+DI  +DN+P P      N K  +N HGTRCAG+V+A ANN  CGVG+AY + IG +RMLDG+V+D VE+ +L    QHIDIYS SWGP+D+G+ V+GP  LAK AF+ GI  GRNGLG+I+VWASGNGGK  D+C CDGY +SI+T+ +++VSE    PWY E C+STLA TYSSG   E+ II+TD+N++C   H+GTSASAP AAGI AL + AN  LTWRD+Q+++V+T+        ++  N A K+ S+ +GFGLMD+G +V +   W  +P  H C       G  ISLK      LS+ TD C    K +V Y+EHV   + L   KRG++ + LISPS + S++L  R +D A   + F  WP MSV FWGE+A G W + I +Y  + +  N  WS   L +YGT+  P
Sbjct:    1 MKIKQIKFSDPLFKKQWYLIRSQFNTKLVDMNVKEAWELGYTGKGVTISILDDGIDYRHDDLKENYDPEASFDINGDDNDPLP------NLKSTENRHGTRCAGEVSAKANNSKCGVGIAYNSRIGAVRMLDGDVTDRVEAEALSFKQQHIDIYSGSWGPDDNGQKVEGPAILAKSAFKKGIRYGRNGLGNIYVWASGNGGKKSDSCACDGYASSIYTISISSVSENNRKPWYLESCASTLASTYSSGDGYEQKIISTDLNNKCAFDHTGTSASAPLAAGIIALLIEANSNLTWRDVQYIIVLTSNPHPFIDGNFIVNGANKKVSNLYGFGLMDSGKLVRIGRLWHKLPSHHFCK--ISYNGKKISLKDKFTVKLSVKTDGCP--GKNKVNYVEHVILYLKLDYDKRGDLRIILISPSGTRSEILPYRPHDFARGPSTFDIWPLMSVQFWGEKASGEWSVEINNYGTKFSKSNGVWSNFELKIYGTEKWP 480

The following BLAST results are available for this feature:

BLAST of Furin-1 vs. Ensembl Human
BLAST of Furin-1 vs. Ensembl Celegans
BLAST of Furin-1 vs. Ensembl Fly
BLAST of Furin-1 vs. Ensembl Zebrafish
BLAST of Furin-1 vs. Ensembl Xenopus
BLAST of Furin-1 vs. Ensembl Mouse
BLAST of Furin-1 vs. UniProt/SwissProt
BLAST of Furin-1 vs. TrEMBL
BLAST of Furin-1 vs. Ensembl Cavefish
BLAST of Furin-1 vs. Ensembl Sea Lamprey
BLAST of Furin-1 vs. Ensembl Yeast
BLAST of Furin-1 vs. Ensembl Nematostella
BLAST of Furin-1 vs. Ensembl Medaka
BLAST of Furin-1 vs. Planmine SMEST

BLAST of Furin-1 vs. Ensembl Human
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Human e!99)
Total hits: 5


Match Name	E-value	Identity	Description
PCSK6	0.000e+0	51.68	proprotein convertase subtilisin/kexin type 6 [Sou...	[more]
PCSK6	0.000e+0	51.95	proprotein convertase subtilisin/kexin type 6 [Sou...	[more]
PCSK6	0.000e+0	51.68	proprotein convertase subtilisin/kexin type 6 [Sou...	[more]
PCSK6	0.000e+0	51.68	proprotein convertase subtilisin/kexin type 6 [Sou...	[more]
FURIN	0.000e+0	50.75	furin, paired basic amino acid cleaving enzyme [So...	[more]

BLAST of Furin-1 vs. Ensembl Celegans
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99)
Total hits: 5


Match Name	E-value	Identity	Description
kpc-1	0.000e+0	50.08	Furin-like protease kpc-1 [Source:UniProtKB/Swiss...	[more]
kpc-1	0.000e+0	50.08	Furin-like protease kpc-1 [Source:UniProtKB/Swiss...	[more]
bli-4	1.947e-159	46.06	Endoprotease bli-4 [Source:UniProtKB/Swiss-Prot;A...	[more]
bli-4	1.947e-159	46.06	Endoprotease bli-4 [Source:UniProtKB/Swiss-Prot;A...	[more]
bli-4	2.734e-159	46.06	Endoprotease bli-4 [Source:UniProtKB/Swiss-Prot;A...	[more]

BLAST of Furin-1 vs. Ensembl Fly
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99)
Total hits: 5


Match Name	E-value	Identity	Description
Fur1	0.000e+0	53.91	gene:FBgn0004509 transcript:FBtr0336806	[more]
Fur1	0.000e+0	53.91	gene:FBgn0004509 transcript:FBtr0089983	[more]
Fur1	0.000e+0	53.73	gene:FBgn0004509 transcript:FBtr0089982	[more]
Fur1	0.000e+0	53.73	gene:FBgn0004509 transcript:FBtr0336805	[more]
Fur1	0.000e+0	53.73	gene:FBgn0004509 transcript:FBtr0336804	[more]

BLAST of Furin-1 vs. Ensembl Zebrafish
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99)
Total hits: 5


Match Name	E-value	Identity	Description
furina	0.000e+0	52.54	furin (paired basic amino acid cleaving enzyme) a ...	[more]
furina	0.000e+0	52.54	furin (paired basic amino acid cleaving enzyme) a ...	[more]
furina	0.000e+0	52.54	furin (paired basic amino acid cleaving enzyme) a ...	[more]
furinb	0.000e+0	52.10	furin (paired basic amino acid cleaving enzyme) b ...	[more]
CR383678.1	0.000e+0	49.24	proprotein convertase subtilisin/kexin type 5a [So...	[more]

BLAST of Furin-1 vs. Ensembl Xenopus
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99)
Total hits: 5


Match Name	E-value	Identity	Description
gdap1l1	0.000e+0	50.94	ganglioside induced differentiation associated pro...	[more]
gdap1l1	0.000e+0	50.94	ganglioside induced differentiation associated pro...	[more]
gdap1l1	0.000e+0	50.94	ganglioside induced differentiation associated pro...	[more]
gdap1l1	0.000e+0	50.94	ganglioside induced differentiation associated pro...	[more]
gdap1l1	0.000e+0	50.94	ganglioside induced differentiation associated pro...	[more]

BLAST of Furin-1 vs. Ensembl Mouse
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99)
Total hits: 5


Match Name	E-value	Identity	Description
Pcsk6	0.000e+0	52.20	proprotein convertase subtilisin/kexin type 6 [Sou...	[more]
Pcsk6	0.000e+0	52.20	proprotein convertase subtilisin/kexin type 6 [Sou...	[more]
Furin	0.000e+0	51.74	furin (paired basic amino acid cleaving enzyme) [S...	[more]
Furin	0.000e+0	51.74	furin (paired basic amino acid cleaving enzyme) [S...	[more]
Furin	0.000e+0	51.74	furin (paired basic amino acid cleaving enzyme) [S...	[more]

BLAST of Furin-1 vs. UniProt/SwissProt
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt)
Total hits: 5


Match Name	E-value	Identity	Description
sp\|P26016\|FUR11_DROME	0.000e+0	53.91	Furin-like protease 1, isoforms 1/1-X/2 OS=Drosoph...	[more]
sp\|P30430\|FUR1C_DROME	0.000e+0	53.73	Furin-like protease 1, isoform 1-CRR OS=Drosophila...	[more]
sp\|Q63415\|PCSK6_RAT	0.000e+0	52.20	Proprotein convertase subtilisin/kexin type 6 OS=R...	[more]
sp\|P29122\|PCSK6_HUMAN	0.000e+0	51.95	Proprotein convertase subtilisin/kexin type 6 OS=H...	[more]
sp\|P09958\|FURIN_HUMAN	0.000e+0	50.75	Furin OS=Homo sapiens OX=9606 GN=FURIN PE=1 SV=2	[more]

BLAST of Furin-1 vs. TrEMBL
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL)
Total hits: 5


Match Name	E-value	Identity	Description
A0A5K4FDH6	0.000e+0	57.87	Uncharacterized protein OS=Schistosoma mansoni OX=...	[more]
A0A4E0RKD3	0.000e+0	60.88	Furin OS=Fasciola hepatica OX=6192 GN=D915_000368 ...	[more]
G7YU09	0.000e+0	62.13	Furin OS=Clonorchis sinensis OX=79923 GN=CLF_11089...	[more]
A0A074Z5Y0	0.000e+0	61.00	P/Homo B domain-containing protein OS=Opisthorchis...	[more]
A0A4S2L075	0.000e+0	61.96	P/Homo B domain-containing protein OS=Opisthorchis...	[more]

BLAST of Furin-1 vs. Ensembl Cavefish
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99)
Total hits: 5


Match Name	E-value	Identity	Description
pcsk6	0.000e+0	50.76	proprotein convertase subtilisin/kexin type 6 [Sou...	[more]
furina	0.000e+0	53.51	furin-1-like [Source:NCBI gene;Acc:103024357]	[more]
furina	0.000e+0	53.51	furin-1-like [Source:NCBI gene;Acc:103024357]	[more]
furinb	0.000e+0	52.14	furin [Source:NCBI gene;Acc:103043208]	[more]
pcsk5b	0.000e+0	49.92	proprotein convertase subtilisin/kexin type 5 [Sou...	[more]

BLAST of Furin-1 vs. Ensembl Sea Lamprey
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99)
Total hits: 4


Match Name	E-value	Identity	Description
pcsk7	1.844e-53	47.19	proprotein convertase subtilisin/kexin type 7 [Sou...	[more]
pcsk2	3.848e-51	34.81	proprotein convertase subtilisin/kexin type 2 [Sou...	[more]
pcsk2	4.802e-48	35.91	proprotein convertase subtilisin/kexin type 2 [Sou...	[more]
ENSPMAT00000001746.1	2.404e-39	41.85	pep scaffold:Pmarinus_7.0:GL481393:30496:45513:1 g...	[more]

BLAST of Furin-1 vs. Ensembl Yeast
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46)
Total hits: 1


Match Name	E-value	Identity	Description
KEX2	5.226e-107	39.71	Kexin, a subtilisin-like protease (proprotein conv...	[more]

BLAST of Furin-1 vs. Ensembl Nematostella
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46)
Total hits: 5


Match Name	E-value	Identity	Description
EDO47748	2.517e-177	47.47	Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7...	[more]
EDO47326	5.308e-167	47.23	Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7...	[more]
EDO32292	2.857e-164	54.32	Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7...	[more]
EDO38851	3.924e-150	43.77	Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7...	[more]
EDO38852	3.779e-147	42.57	Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7...	[more]

BLAST of Furin-1 vs. Ensembl Medaka
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99)
Total hits: 5


Match Name	E-value	Identity	Description
furina	0.000e+0	51.45	furin-1 [Source:NCBI gene;Acc:100049240]	[more]
pcsk6	0.000e+0	51.39	proprotein convertase subtilisin/kexin type 6 [Sou...	[more]
furinb	0.000e+0	50.69	furin, paired basic amino acid cleaving enzyme [So...	[more]
furinb	0.000e+0	51.65	furin, paired basic amino acid cleaving enzyme [So...	[more]
pcsk5b	1.728e-176	51.02	proprotein convertase subtilisin/kexin type 5 [Sou...	[more]

BLAST of Furin-1 vs. Planmine SMEST
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST)
Total hits: 5


Match Name	E-value	Identity	Description
SMESG000049794.1	0.000e+0	100.00	SMESG000049794.1	[more]
SMESG000018546.1	1.786e-146	48.57	SMESG000018546.1	[more]
SMESG000018546.1	5.619e-143	50.00	SMESG000018546.1	[more]
SMESG000018546.1	1.017e-142	50.00	SMESG000018546.1	[more]
SMESG000018546.1	3.863e-139	48.57	SMESG000018546.1	[more]

Analyses

This transcript is derived from or has results from the following analyses


Analysis Name	Date Performed
Embryonic Stages	2016-07-25
Schmidtea mediterranea smed_20140614 BLASTX Human e!99	2016-08-08
Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99	2016-08-08
Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL	2020-05-01
Schmidtea mediterranea Sexual smed_20140614 transcriptome	2016-07-25
Schmidtea mediteranean smed_20140614 Interproscan	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST	2020-05-08

Sequences

The following sequences are available for this feature:

transcript sequence
protein sequence

transcript sequence

>SMED30011738 ID=SMED30011738|Name=Furin-1|organism=Schmidtea mediterranea sexual|type=transcript|length=2237bp
TGTTGAAGTCGTTATAATTAAATGAAATTACGTCAGGTTTTATTACAAAT
TAGGCGTTGTCAGTTGGAAAATTTTAGTGCAATAAATTTATAATATGAAT
ATATTGTAATGAAGTGTTTTGTAATTCTCTTCTCATCTCTCTTTTGTTTC
GGCGCCAAATCTCAATCAGAATCACGTGGCCATTATACAGACACTTGGGC
AGTCCAAATCAACGGAACAGTTGACGACGCAAGGATATTAGCCGCCACAT
ATGGATTCGTTTTTCTCAATGAGATAATGCCGTCCATTTATTCATTCAAG
CACCGACGAGTATCAAAGCGCTCAATTTATCCGAGCAATTACTATCAGAG
CAATTTATCCGATGATCCAAGAGTCATCTGGTTGGAGCAACAATTTGCCA
AAGTCAGGGTGAAACGGCACATTGTCAATGATCCAAAATGGTACAAAATG
TGGTATCTGAATAAAATGAATAAAGAAAACTCAATGAATATTATATCAGC
TTGGAAAAAGGGATACAGGGGTCAGAATGTCGTCGTGTCTATCCTCGATG
ATGGAATAGAAAAAGATCATCCGGACCTCAAAGAAAACTATGATCCAAAC
GCGTCGTATGACATCATCAGTAACGACAACAATCCGGAGCCCCGATATAT
TTCCAGCAACAATACCAAGATCAAAGATAATCACCATGGTACCAGATGCG
CCGGTCAAGTGGCAGCTACGGCAAATAATCGGATATGCGGAGTTGGGGTG
GCGTACAAGGCTAATATCGGAGGAATACGAATGCTCGATGGAGAGGTTTC
AGATAGCGTTGAGAGTCATTCGTTGAGATTGTTTTATCAACATATCGATA
TTTACTCGGCCAGTTGGGGACCGGAGGATGATGGGAAAACTGTTGATGGG
CCAGGAGAACTTGCCAAAATTGCATTTGAAGATGGCATACTAAAGGGTAG
GAATGGTCTGGGATCTATTTTTGTTTGGGCAAGTGGTAATGGGGGAAAGA
ATCATGATAACTGCAATTGTGATGGATACACCAATAGTATTTTTACTCTG
GGAGTCAATGCTGTCTCTGAAATTGGGGATGCTCCGTGGTATGCAGAAAA
ATGTTCCTCCACTTTGGCGGTAACCTATAGTAGCGGCAGTATGGATGAGC
GGGCTATTATCACAACTGATGTGAACCATGAGTGCACGGAACAACATTCT
GGGACTTCAGCGAGTGCTCCTTTTGCCGCGGGGATTTGTGCATTGGCCTT
ATCTGCTAATAGGTTTCTTACTTGGCGAGACATGCAGCATTTAGTTGTCA
TTACAGCTCGAAAGGCTAATTTGAGAGCTGTCGATTGGAGCACGAACGCT
GCAGGGAAAGAGTACTCTCATTCTTTTGGATTTGGGCTAATGGATGCCGG
TGCAATGGTTGATTTAGCTCTCAACTGGACAACAGTACCCGAGCAACATA
TTTGCCATTATGTGGCCCCAATGCAAGGTGGGCCTATTTCATTGAAACCG
TATGCAAATGAAGTATTATCTATCACAACTGATGCTTGCTCAGATAATTC
TAAAAAACGTGTCAGATACCTTGAACATGTCCAGGCAAAAATTTCTCTGC
GTAGTACTAAAAGAGGGGAAGTCGAATTGTGGCTCATTTCACCGAGTAGA
TCAACCAGCAAGCTGCTTACCAAACGTCGAAATGATGTAGCAAGCGCTGG
CTTTCATCACTGGCCTTTCATGTCAGTCCATTTTTGGGGCGAAGAAGCTC
CAGGAACTTGGAAGTTGACAATATATTCATATGATGCAGAAGTAACCCTC
ATCAATTGGTCGTTAATCCTCTATGGGACAGACACCTTGCCGTCACATCG
TCAGAACAGTACCCACACCAAATCACAGAAACGACCGCCGAAAAATGTTC
CTTACATAAACAATAATAACGAAAGAAATTTAGAAACAAGTTTCGAAGTC
AAAGAAAATCAAATAATATTTCCACAAAGTTCTCACAGTCTTCGGTTTTC
ATTCAAGCTCATTTTCATCAGTGTTTTATTAATTGGCTATAGATAGTTGT
CAATCTTATCACTTTTGTGCAATGACTTCCAACCAGACTTTTCAGAAGGT
CTAGTCAAGTTGTTCATTGAATGTCTTCAATACATATGATGCAATCATGT
TCAGTCTCCAAGGATTTCCTGATCATATCACTTGTAACTGTCACTTTTTG
GCTCATCAATTGTATATTGAACTCATTTAACTTAACT

protein sequence of SMED30011738-orf-1

>SMED30011738-orf-1 ID=SMED30011738-orf-1|Name=SMED30011738-orf-1|organism=Schmidtea mediterranea sexual|type=polypeptide|length=646bp
MKCFVILFSSLFCFGAKSQSESRGHYTDTWAVQINGTVDDARILAATYGF
VFLNEIMPSIYSFKHRRVSKRSIYPSNYYQSNLSDDPRVIWLEQQFAKVR
VKRHIVNDPKWYKMWYLNKMNKENSMNIISAWKKGYRGQNVVVSILDDGI
EKDHPDLKENYDPNASYDIISNDNNPEPRYISSNNTKIKDNHHGTRCAGQ
VAATANNRICGVGVAYKANIGGIRMLDGEVSDSVESHSLRLFYQHIDIYS
ASWGPEDDGKTVDGPGELAKIAFEDGILKGRNGLGSIFVWASGNGGKNHD
NCNCDGYTNSIFTLGVNAVSEIGDAPWYAEKCSSTLAVTYSSGSMDERAI
ITTDVNHECTEQHSGTSASAPFAAGICALALSANRFLTWRDMQHLVVITA
RKANLRAVDWSTNAAGKEYSHSFGFGLMDAGAMVDLALNWTTVPEQHICH
YVAPMQGGPISLKPYANEVLSITTDACSDNSKKRVRYLEHVQAKISLRST
KRGEVELWLISPSRSTSKLLTKRRNDVASAGFHHWPFMSVHFWGEEAPGT
WKLTIYSYDAEVTLINWSLILYGTDTLPSHRQNSTHTKSQKRPPKNVPYI
NNNNERNLETSFEVKENQIIFPQSSHSLRFSFKLIFISVLLIGYR*

Annotated Terms

The following terms have been associated with this transcript:

Vocabulary: **cellular component**
Term	Definition
GO:0005576	extracellular region
GO:0005768	endosome
GO:0005794	Golgi apparatus
GO:0005886	plasma membrane
GO:0010008	endosome membrane
GO:0016020	membrane
GO:0016021	integral component of membrane

Vocabulary: **molecular function**
Term	Definition
GO:0046872	metal ion binding
GO:0004252	serine-type endopeptidase activity
GO:0016787	hydrolase activity
GO:0008233	peptidase activity
GO:0008236	serine-type peptidase activity

Vocabulary: **biological process**
Term	Definition
GO:1901394	positive regulation of transforming growth factor beta1 activation
GO:0006508	proteolysis

Vocabulary: **Planarian Anatomy**
Term	Definition
PLANA:0003104	enteric muscle cell

Vocabulary: **INTERPRO**
Term	Definition
IPR036852	Peptidase_S8/S53_dom_sf
IPR038466	S8_pro-domain_sf
IPR034182	Kexin/furin
IPR015500	Peptidase_S8_subtilisin-rel
IPR032815	S8_pro-domain
IPR000209	Peptidase_S8/S53_dom
IPR002884	P_dom
IPR008979	Galactose-bd-like_sf
IPR022398	Peptidase_S8_His-AS
IPR023827	Peptidase_S8_Asp-AS
IPR023828	Peptidase_S8_Ser-AS
IPR009020	Propept_inh

InterPro

Analysis Name: Schmidtea mediteranean smed_20140614 Interproscan
Date Performed: 2020-05-01


IPR Term	IPR Description	Source	Source Term	Source Description	Alignment
IPR015500	Peptidase S8, subtilisin-related	PRINTS	PR00723	SUBTILISIN	coord: 189..202 score: 52.37 coord: 364..380 score: 57.65 coord: 138..157 score: 46.62
IPR032815	Peptidase S8, pro-domain	PFAM	PF16470	S8_pro-domain	coord: 29..103 e-value: 8.8E-17 score: 61.7
IPR000209	Peptidase S8/S53 domain	PFAM	PF00082	Peptidase_S8	coord: 138..426 e-value: 1.3E-47 score: 162.5
IPR036852	Peptidase S8/S53 domain superfamily	GENE3D	G3DSA:3.40.50.200		coord: 108..437 e-value: 3.3E-92 score: 311.3
IPR036852	Peptidase S8/S53 domain superfamily	SUPERFAMILY	SSF52743	Subtilisin-like	coord: 105..440
IPR002884	P domain	PFAM	PF01483	P_proprotein	coord: 488..571 e-value: 9.1E-22 score: 76.9
IPR002884	P domain	PROSITE	PS51829	P_HOMO_B	coord: 442..577 score: 43.074
IPR038466	Peptidase S8, pro-domain superfamily	GENE3D	G3DSA:3.30.70.850		coord: 17..103 e-value: 3.1E-23 score: 84.0
IPR008979	Galactose-binding-like domain superfamily	GENE3D	G3DSA:2.60.120.260		coord: 441..574 e-value: 4.6E-39 score: 135.0
IPR008979	Galactose-binding-like domain superfamily	SUPERFAMILY	SSF49785	Galactose-binding domain-like	coord: 434..578
None	No IPR available	MOBIDB_LITE	mobidb-lite	disorder_prediction	coord: 581..602
None	No IPR available	PANTHER	PTHR42884:SF3	FURIN-LIKE PROTEASE 1, ISOFORMS 1/1-X/2	coord: 21..603
None	No IPR available	PANTHER	PTHR42884	FAMILY NOT NAMED	coord: 21..603
None	No IPR available	PROSITE	PS51892	SUBTILASE	coord: 114..434 score: 42.292
None	No IPR available	SIGNALP_EUK	SignalP-noTM	SignalP-noTM	coord: 1..18 score: 0.72
None	No IPR available	SUPERFAMILY	SSF54897	Protease propeptides/inhibitors	coord: 26..95
IPR023828	Peptidase S8, subtilisin, Ser-active site	PROSITE	PS00138	SUBTILASE_SER	coord: 365..375
IPR023827	Peptidase S8, subtilisin, Asp-active site	PROSITE	PS00136	SUBTILASE_ASP	coord: 143..154
IPR022398	Peptidase S8, subtilisin, His-active site	PROSITE	PS00137	SUBTILASE_HIS	coord: 193..203
IPR034182	Kexin/furin catalytic domain	CDD	cd04059	Peptidases_S8_Protein_convertases_Kexins_Furin-like	coord: 107..401 e-value: 1.85069E-161 score: 462.8