Signal recognition particle 19 kDa protein

Overview
NameSignal recognition particle 19 kDa protein
Smed IDSMED30011729
Length (bp)619
Neoblast Clusters

Zeng et. al., 2018



▻ Overview

▻ Neoblast Population

▻ Sub-lethal Irradiated Surviving X1 and X2 Cell Population

 

 

Overview

 

Single cell RNA-seq of pluripotent neoblasts and its early progenies


We isolated X1 neoblasts cells enriched in high piwi-1 expression (Neoblast Population), and profiled ∼7,614 individual cells via scRNA-seq. Unsupervised analyses uncovered 12 distinct classes from 7,088 high-quality cells. We designated these classes Nb1 to Nb12 and ordered them based on high (Nb1) to low (Nb12) piwi-1 expression levels. We further defined groups of genes that best classified the cells parsed into 12 distinct cell clusters to generate a scaled expression heat map of discriminative gene sets for each cluster. Expression of each cluster’s gene signatures was validated using multiplex fluorescence in situ hybridization (FISH) co-stained with piwi-1 and largely confirmed the cell clusters revealed by scRNA-seq.

We also tested sub-lethal irradiation exposure. To profile rare pluripotent stem cells (PSCs) and avoid interference from immediate progenitor cells, we determined a time point after sub-lethal irradiation (7 DPI) with minimal piwi-1+ cells, followed by isolation and single-cell RNA-seq of 1,200 individual cells derived from X1 (Piwi-1 high) and X2 (Piwi-1 low) cell populations (Sub-lethal Irradiated Surviving X1 and X2 Cell Population)



Explore this single cell expression dataset with our NB Cluster Shiny App



 

Neoblast Population

 

t-SNE plot shows two-dimensional representation of global gene expression relationships among all neoblasts (n = 7,088 after filter). Cluster identity was assigned based on the top 10 marker genes of each cluster (Table S2), followed by inspection of RNA in situ hybridization patterns. Neoblast groups, Nb.


Expression of Signal recognition particle 19 kDa protein (SMED30011729) t-SNE clustered cells

Violin plots show distribution of expression levels for Signal recognition particle 19 kDa protein (SMED30011729) in cells (dots) of each of the 12 neoblast clusters.

 

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Sub-lethal Irradiated Surviving X1 and X2 Cell Population

 

t-SNE plot of surviving X1 and X2 cells (n = 1,039 after QC filter) after sub-lethal irradiation. Colors indicate unbiased cell classification via graph-based clustering. SL, sub-lethal irradiated cell groups.

Expression of Signal recognition particle 19 kDa protein (SMED30011729) in the t-SNE clustered sub-lethally irradiated X1 and X2 cells.

Violin plots show distribution of expression levels for Signal recognition particle 19 kDa protein (SMED30011729) in cells (dots) of each of the 10 clusters of sub-leathally irradiated X1 and X2 cells.

 

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Embryonic Expression

Davies et. al., 2017

Hover the mouse over a column in the graph to view average RPKM values per sample.
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Embryonic Stages: Y: yolk. S2-S8: Stages 2-8. C4: asexual adult. SX: virgin, sexually mature adult.
For further information about sample preparation and analysis for the single animal RNA-Seq experiment, please refer to the Materials and Methods

 

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Anatomical Expression

PAGE et. al., 2020



SMED30011729

has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGE



PAGE Curations: 2

  
Expressed InReference TranscriptGene ModelsPublished TranscriptTranscriptomePublicationSpecimenLifecycleEvidence
epidermisSMED30011729h1SMcG0007942 dd_Smed_v4_4204_1_1dd_Smed_v4PMID:29674431
Fincher et al., 2018		FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
muscle cellSMED30011729h1SMcG0007942 dd_Smed_v4_4204_1_1dd_Smed_v4PMID:29674431
Fincher et al., 2018		FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
Note: Hover over icons to view figure legend
Homology
[Close]
BLAST of Signal recognition particle 19 kDa protein vs. Ensembl Human
Match: SRP19 (signal recognition particle 19 [Source:HGNC Symbol;Acc:HGNC:11300])

HSP 1 Score: 104.375 bits (259), Expect = 5.746e-28
Identity = 52/111 (46.85%), Postives = 71/111 (63.96%), Query Frame = 2 
Query:   92 SHCDRERWICIYPIYLNSKRTISEGRKMSMKYCVENPKFDEIRDVLLEAGLQIGVEDKVHPKVQDSKESKSRGRIRVQLKNESGQPILEHFPDRISVLKYLGETIPKLKAR 424
            S  D++R+ICIYP YLN+K+TI+EGR++ +   VENP   EI+DV    GL + +E       + +++ + RGR+RVQLK E G   L  FP R SV+ Y  E IPKLK R
Sbjct:    8 SPADQDRFICIYPAYLNNKKTIAEGRRIPISKAVENPTATEIQDVCSAVGLNVFLEKNKMYSREWNRDVQYRGRVRVQLKQEDGSLCLVQFPSRKSVMLYAAEMIPKLKTR 118
[Close]
BLAST of Signal recognition particle 19 kDa protein vs. Ensembl Human
Match: SRP19 (signal recognition particle 19 [Source:HGNC Symbol;Acc:HGNC:11300])

HSP 1 Score: 85.8853 bits (211), Expect = 2.252e-21
Identity = 42/94 (44.68%), Postives = 60/94 (63.83%), Query Frame = 2 
Query:   92 SHCDRERWICIYPIYLNSKRTISEGRKMSMKYCVENPKFDEIRDVLLEAGLQIGVEDKVHPKVQDSKESKSRGRIRVQLKNESGQPILEHFPDR 373
            S  D++R+ICIYP YLN+K+TI+EGR++ +   VENP   EI+DV    GL + +E       + +++ + RGR+RVQLK E G   L  FP R
Sbjct:    8 SPADQDRFICIYPAYLNNKKTIAEGRRIPISKAVENPTATEIQDVCSAVGLNVFLEKNKMYSREWNRDVQYRGRVRVQLKQEDGSLCLVQFPSR 101
[Close]
BLAST of Signal recognition particle 19 kDa protein vs. Ensembl Human
Match: SRP19 (signal recognition particle 19 [Source:HGNC Symbol;Acc:HGNC:11300])

HSP 1 Score: 85.8853 bits (211), Expect = 2.392e-21
Identity = 42/94 (44.68%), Postives = 60/94 (63.83%), Query Frame = 2 
Query:   92 SHCDRERWICIYPIYLNSKRTISEGRKMSMKYCVENPKFDEIRDVLLEAGLQIGVEDKVHPKVQDSKESKSRGRIRVQLKNESGQPILEHFPDR 373
            S  D++R+ICIYP YLN+K+TI+EGR++ +   VENP   EI+DV    GL + +E       + +++ + RGR+RVQLK E G   L  FP R
Sbjct:    8 SPADQDRFICIYPAYLNNKKTIAEGRRIPISKAVENPTATEIQDVCSAVGLNVFLEKNKMYSREWNRDVQYRGRVRVQLKQEDGSLCLVQFPSR 101
[Close]
BLAST of Signal recognition particle 19 kDa protein vs. Ensembl Human
Match: SRP19 (signal recognition particle 19 [Source:HGNC Symbol;Acc:HGNC:11300])

HSP 1 Score: 84.3445 bits (207), Expect = 1.016e-20
Identity = 41/97 (42.27%), Postives = 61/97 (62.89%), Query Frame = 2 
Query:   92 SHCDRERWICIYPIYLNSKRTISEGRKMSMKYCVENPKFDEIRDVLLEAGLQIGVEDKVHPKVQDSKESKSRGRIRVQLKNESGQPILEHFPDRISV 382
            S  D++R+ICIYP YLN+K+TI+EGR++ +   VENP   EI+DV    GL + +E       + +++ + RGR+RVQLK E G   L  FP   ++
Sbjct:    8 SPADQDRFICIYPAYLNNKKTIAEGRRIPISKAVENPTATEIQDVCSAVGLNVFLEKNKMYSREWNRDVQYRGRVRVQLKQEDGSLCLVQFPSHYTL 104
[Close]
BLAST of Signal recognition particle 19 kDa protein vs. Ensembl Human
Match: SRP19 (signal recognition particle 19 [Source:HGNC Symbol;Acc:HGNC:11300])

HSP 1 Score: 75.485 bits (184), Expect = 4.207e-17
Identity = 43/111 (38.74%), Postives = 63/111 (56.76%), Query Frame = 2 
Query:   92 SHCDRERWICIYPIYLNSKRTISEGRKMSMKYCVENPKFDEIRDVLLEAGLQIGVEDKVHPKVQDSKESKSRGRIRVQLKNESGQPILEHFPDRISVLKYLGETIPKLKAR 424
            S  D++R+ICIYP YLN+K+TI+EGR++                        I  ++K++ + + +++ + RGR+RVQLK E G   L  FP R SV+ Y  E IPKLK R
Sbjct:    8 SPADQDRFICIYPAYLNNKKTIAEGRRIP-----------------------ISKKNKMYSR-EWNRDVQYRGRVRVQLKQEDGSLCLVQFPSRKSVMLYAAEMIPKLKTR 94
[Close]
BLAST of Signal recognition particle 19 kDa protein vs. Ensembl Celegans
Match: F37F2.2 (Probable signal recognition particle 19 kDa protein [Source:UniProtKB/Swiss-Prot;Acc:O61749])

HSP 1 Score: 79.337 bits (194), Expect = 7.820e-19
Identity = 46/109 (42.20%), Postives = 64/109 (58.72%), Query Frame = 2 
Query:  104 RERWICIYPIYLNSKRTISEGRKMSMKYCVENPKFDEIRDVLLEAGLQIGVE-DKVHPKVQDSKESKSRGRIRVQLKNESGQPILEHFPDRISVLKYLGETIPKLKARQ 427
            ++RWI IYP Y++ K+T  +GRK+S    VENP   EI DVL   G    +E  K +P+    ++ + +GR+RVQLKN+ G    E    R  + K + E IPKLK RQ
Sbjct:   12 QKRWIVIYPAYIDKKKTAKQGRKISQILAVENPTSVEIHDVLAAVGFNPLLERTKCYPR-DGERDFEVQGRVRVQLKNDDGTAKHEQ-KTRDEIFKMVAEMIPKLKTRQ 118
[Close]
BLAST of Signal recognition particle 19 kDa protein vs. Ensembl Celegans
Match: F37F2.2 (Probable signal recognition particle 19 kDa protein [Source:UniProtKB/Swiss-Prot;Acc:O61749])

HSP 1 Score: 79.337 bits (194), Expect = 7.820e-19
Identity = 46/109 (42.20%), Postives = 64/109 (58.72%), Query Frame = 2 
Query:  104 RERWICIYPIYLNSKRTISEGRKMSMKYCVENPKFDEIRDVLLEAGLQIGVE-DKVHPKVQDSKESKSRGRIRVQLKNESGQPILEHFPDRISVLKYLGETIPKLKARQ 427
            ++RWI IYP Y++ K+T  +GRK+S    VENP   EI DVL   G    +E  K +P+    ++ + +GR+RVQLKN+ G    E    R  + K + E IPKLK RQ
Sbjct:   12 QKRWIVIYPAYIDKKKTAKQGRKISQILAVENPTSVEIHDVLAAVGFNPLLERTKCYPR-DGERDFEVQGRVRVQLKNDDGTAKHEQ-KTRDEIFKMVAEMIPKLKTRQ 118
[Close]
BLAST of Signal recognition particle 19 kDa protein vs. Ensembl Fly
Match: Srp19 (gene:FBgn0015298 transcript:FBtr0076879)

HSP 1 Score: 116.701 bits (291), Expect = 5.959e-33
Identity = 57/124 (45.97%), Postives = 82/124 (66.13%), Query Frame = 2 
Query:   65 MTRPWNPSFSHCDRERWICIYPIYLNSKRTISEGRKMSMKYCVENPKFDEIRDVLLEAGLQIGVEDKVHPKVQDSKESKSRGRIRVQLKNESGQPILEHFPDRISVLKYLGETIPKLKARQSIS 436
            M + W+PS  H D ERWICIYP Y+N K+T  EGR++  + CV+NP + EIRDVL  + LQ  +E+K + + ++S E + RGR+RVQL+N  G      FP R S++ ++   IP+LK RQ+ S
Sbjct:    7 MKKNWSPSMKHNDMERWICIYPAYINRKKTRQEGRRLPKENCVDNPSYIEIRDVLSVSNLQFLMENKKYCR-ENSSEMEFRGRVRVQLRNVDGTLYNNDFPTRESIMLHIASKIPQLKTRQNKS 129
[Close]
BLAST of Signal recognition particle 19 kDa protein vs. Ensembl Zebrafish
Match: srp19 (signal recognition particle 19 [Source:ZFIN;Acc:ZDB-GENE-040426-2657])

HSP 1 Score: 103.605 bits (257), Expect = 5.700e-28
Identity = 52/115 (45.22%), Postives = 78/115 (67.83%), Query Frame = 2 
Query:   80 NPSFSHCDRERWICIYPIYLNSKRTISEGRKMSMKYCVENPKFDEIRDVLLEAGLQIGVEDKVHPKVQDSKESKSRGRIRVQLKNESGQPILEHFPDRISVLKYLGETIPKLKAR 424
            NP+    D+ER++CIYP Y+NSK+T++EGR++     VENP   EI+ VL  AGL + VE+ ++P+ + +++ + RGR+RVQLK E G    + F  R  V+ Y+ E IPKLK+R
Sbjct:    7 NPA----DKERFLCIYPAYINSKKTLAEGRRIPTDKAVENPTCAEIQGVLSAAGLNVHVENSMYPR-EWNRDVQFRGRVRVQLKMEDGSFCQDKFTSRKDVMFYVAEMIPKLKSR 116
[Close]
BLAST of Signal recognition particle 19 kDa protein vs. Ensembl Xenopus
Match: uso1 (USO1 vesicle transport factor [Source:Xenbase;Acc:XB-GENE-1013306])

HSP 1 Score: 92.4337 bits (228), Expect = 1.603e-23
Identity = 48/116 (41.38%), Postives = 75/116 (64.66%), Query Frame = 2 
Query:   80 NPSFSHCDRERWICIYPIYLNSKRTISEGRKMSMKYCVENPKFDEIRDVLLEAGLQIGVE-DKVHPKVQDSKESKSRGRIRVQLKNESGQPILEHFPDRISVLKYLGETIPKLKAR 424
            N   SH   +R+ICIYP YLNSK+TI+EGR++ ++  V+NP   EI D+     L   VE DK++ + + +++++ RGR+RVQL+NE G   ++    R +++  + E IPKLK R
Sbjct:    3 NLEKSHASVDRFICIYPAYLNSKKTIAEGRRIPIEKAVQNPTCSEIADICRANKLNAVVEGDKMYTR-EWNRDTQFRGRVRVQLRNEDGSSCVDKLSSRKAIMLRVAEEIPKLKTR 117
[Close]
BLAST of Signal recognition particle 19 kDa protein vs. Ensembl Xenopus
Match: uso1 (USO1 vesicle transport factor [Source:Xenbase;Acc:XB-GENE-1013306])

HSP 1 Score: 87.0409 bits (214), Expect = 1.957e-21
Identity = 44/105 (41.90%), Postives = 70/105 (66.67%), Query Frame = 2 
Query:  113 WICIYPIYLNSKRTISEGRKMSMKYCVENPKFDEIRDVLLEAGLQIGVE-DKVHPKVQDSKESKSRGRIRVQLKNESGQPILEHFPDRISVLKYLGETIPKLKAR 424
            +ICIYP YLNSK+TI+EGR++ ++  V+NP   EI D+     L   VE DK++ + + +++++ RGR+RVQL+NE G   ++    R +++  + E IPKLK R
Sbjct:    9 FICIYPAYLNSKKTIAEGRRIPIEKAVQNPTCSEIADICRANKLNAVVEGDKMYTR-EWNRDTQFRGRVRVQLRNEDGSSCVDKLSSRKAIMLRVAEEIPKLKTR 112
[Close]
BLAST of Signal recognition particle 19 kDa protein vs. Ensembl Mouse
Match: Srp19 (signal recognition particle 19 [Source:MGI Symbol;Acc:MGI:1913634])

HSP 1 Score: 103.605 bits (257), Expect = 7.854e-28
Identity = 52/111 (46.85%), Postives = 71/111 (63.96%), Query Frame = 2 
Query:   92 SHCDRERWICIYPIYLNSKRTISEGRKMSMKYCVENPKFDEIRDVLLEAGLQIGVEDKVHPKVQDSKESKSRGRIRVQLKNESGQPILEHFPDRISVLKYLGETIPKLKAR 424
            S  D++R+ICIYP YLN+K+TI+EGR++ +   VENP   EI+DV    GL   +E       + +++ + RGR+RVQLK E G   L  FP R SV+ Y+ E IPKLK R
Sbjct:    8 SPADQDRFICIYPAYLNNKKTIAEGRRIPISKAVENPTATEIQDVCSAVGLNAFLEKNKMYSREWNRDVQFRGRVRVQLKQEDGSLCLVQFPSRKSVMLYVAEMIPKLKTR 118
[Close]
BLAST of Signal recognition particle 19 kDa protein vs. Ensembl Mouse
Match: Srp19 (signal recognition particle 19 [Source:MGI Symbol;Acc:MGI:1913634])

HSP 1 Score: 75.8702 bits (185), Expect = 1.871e-17
Identity = 43/111 (38.74%), Postives = 64/111 (57.66%), Query Frame = 2 
Query:   92 SHCDRERWICIYPIYLNSKRTISEGRKMSMKYCVENPKFDEIRDVLLEAGLQIGVEDKVHPKVQDSKESKSRGRIRVQLKNESGQPILEHFPDRISVLKYLGETIPKLKAR 424
            S  D++R+ICIYP YLN+K+TI+EGR++                        I  ++K++ + + +++ + RGR+RVQLK E G   L  FP R SV+ Y+ E IPKLK R
Sbjct:    8 SPADQDRFICIYPAYLNNKKTIAEGRRIP-----------------------ISKKNKMYSR-EWNRDVQFRGRVRVQLKQEDGSLCLVQFPSRKSVMLYVAEMIPKLKTR 94
[Close]
BLAST of Signal recognition particle 19 kDa protein vs. Ensembl Mouse
Match: Srp19 (signal recognition particle 19 [Source:MGI Symbol;Acc:MGI:1913634])

HSP 1 Score: 43.1282 bits (100), Expect = 5.329e-6
Identity = 17/30 (56.67%), Postives = 26/30 (86.67%), Query Frame = 2 
Query:   92 SHCDRERWICIYPIYLNSKRTISEGRKMSM 181
            S  D++R+ICIYP YLN+K+TI+EGR++ +
Sbjct:    8 SPADQDRFICIYPAYLNNKKTIAEGRRIPI 37
[Close]
BLAST of Signal recognition particle 19 kDa protein vs. UniProt/SwissProt
Match: sp|P49963|SRP19_DROME (Signal recognition particle 19 kDa protein OS=Drosophila melanogaster OX=7227 GN=Srp19 PE=2 SV=2)

HSP 1 Score: 116.701 bits (291), Expect = 5.973e-32
Identity = 57/124 (45.97%), Postives = 82/124 (66.13%), Query Frame = 2 
Query:   65 MTRPWNPSFSHCDRERWICIYPIYLNSKRTISEGRKMSMKYCVENPKFDEIRDVLLEAGLQIGVEDKVHPKVQDSKESKSRGRIRVQLKNESGQPILEHFPDRISVLKYLGETIPKLKARQSIS 436
            M + W+PS  H D ERWICIYP Y+N K+T  EGR++  + CV+NP + EIRDVL  + LQ  +E+K + + ++S E + RGR+RVQL+N  G      FP R S++ ++   IP+LK RQ+ S
Sbjct:    7 MKKNWSPSMKHNDMERWICIYPAYINRKKTRQEGRRLPKENCVDNPSYIEIRDVLSVSNLQFLMENKKYCR-ENSSEMEFRGRVRVQLRNVDGTLYNNDFPTRESIMLHIASKIPQLKTRQNKS 129
[Close]
BLAST of Signal recognition particle 19 kDa protein vs. UniProt/SwissProt
Match: sp|Q3ZBG7|SRP19_BOVIN (Signal recognition particle 19 kDa protein OS=Bos taurus OX=9913 GN=SRP19 PE=2 SV=1)

HSP 1 Score: 104.375 bits (259), Expect = 2.323e-27
Identity = 52/111 (46.85%), Postives = 71/111 (63.96%), Query Frame = 2 
Query:   92 SHCDRERWICIYPIYLNSKRTISEGRKMSMKYCVENPKFDEIRDVLLEAGLQIGVEDKVHPKVQDSKESKSRGRIRVQLKNESGQPILEHFPDRISVLKYLGETIPKLKAR 424
            S  D++R+ICIYP YLN+K+TI+EGR++ +   VENP   EI+DV    GL + +E       + +++ + RGR+RVQLK E G   L  FP R SV+ Y  E IPKLK R
Sbjct:    8 SPADQDRFICIYPAYLNNKKTIAEGRRIPISKAVENPTATEIQDVCAAVGLNVFLEKNKMYSREWNRDLQYRGRVRVQLKQEDGSLCLVQFPSRKSVMLYAAEMIPKLKTR 118
[Close]
BLAST of Signal recognition particle 19 kDa protein vs. UniProt/SwissProt
Match: sp|Q5RBR1|SRP19_PONAB (Signal recognition particle 19 kDa protein OS=Pongo abelii OX=9601 GN=SRP19 PE=1 SV=2)

HSP 1 Score: 104.375 bits (259), Expect = 2.759e-27
Identity = 52/111 (46.85%), Postives = 71/111 (63.96%), Query Frame = 2 
Query:   92 SHCDRERWICIYPIYLNSKRTISEGRKMSMKYCVENPKFDEIRDVLLEAGLQIGVEDKVHPKVQDSKESKSRGRIRVQLKNESGQPILEHFPDRISVLKYLGETIPKLKAR 424
            S  D++R+ICIYP YLN+K+TI+EGR++ +   VENP   EI+DV    GL + +E       + +++ + RGR+RVQLK E G   L  FP R SV+ Y  E IPKLK R
Sbjct:    8 SPADQDRFICIYPAYLNNKKTIAEGRRIPISKAVENPTATEIQDVCSAVGLNVFLEKNKMYSREWNRDVQYRGRVRVQLKQEDGSLCLVQFPSRKSVMLYAAEMIPKLKTR 118
[Close]
BLAST of Signal recognition particle 19 kDa protein vs. UniProt/SwissProt
Match: sp|P09132|SRP19_HUMAN (Signal recognition particle 19 kDa protein OS=Homo sapiens OX=9606 GN=SRP19 PE=1 SV=3)

HSP 1 Score: 104.375 bits (259), Expect = 2.759e-27
Identity = 52/111 (46.85%), Postives = 71/111 (63.96%), Query Frame = 2 
Query:   92 SHCDRERWICIYPIYLNSKRTISEGRKMSMKYCVENPKFDEIRDVLLEAGLQIGVEDKVHPKVQDSKESKSRGRIRVQLKNESGQPILEHFPDRISVLKYLGETIPKLKAR 424
            S  D++R+ICIYP YLN+K+TI+EGR++ +   VENP   EI+DV    GL + +E       + +++ + RGR+RVQLK E G   L  FP R SV+ Y  E IPKLK R
Sbjct:    8 SPADQDRFICIYPAYLNNKKTIAEGRRIPISKAVENPTATEIQDVCSAVGLNVFLEKNKMYSREWNRDVQYRGRVRVQLKQEDGSLCLVQFPSRKSVMLYAAEMIPKLKTR 118
[Close]
BLAST of Signal recognition particle 19 kDa protein vs. UniProt/SwissProt
Match: sp|Q9D7A6|SRP19_MOUSE (Signal recognition particle 19 kDa protein OS=Mus musculus OX=10090 GN=Srp19 PE=1 SV=1)

HSP 1 Score: 97.8265 bits (242), Expect = 7.945e-25
Identity = 50/108 (46.30%), Postives = 69/108 (63.89%), Query Frame = 2 
Query:  101 DRERWICIYPIYLNSKRTISEGRKMSMKYCVENPKFDEIRDVLLEAGLQIGVEDKVHPKVQDSKESKSRGRIRVQLKNESGQPILEHFPDRISVLKYLGETIPKLKAR 424
            D++R+I IYP YLN+K+TI+EGR++ +   VENP   EI+DV    GL   +E       + +++ + RGR+RVQLK E G   L  FP R SV+ Y+ E IPKLK R
Sbjct:   11 DQDRFIFIYPAYLNNKKTIAEGRRIPISKAVENPTATEIQDVCSAVGLNAFLEKNKMYSREWNRDVQFRGRVRVQLKQEDGSLCLVQFPSRKSVMLYVAEMIPKLKTR 118
[Close]
BLAST of Signal recognition particle 19 kDa protein vs. TrEMBL
Match: R7V1R5 (Uncharacterized protein OS=Capitella teleta OX=283909 GN=CAPTEDRAFT_172694 PE=4 SV=1)

HSP 1 Score: 170.244 bits (430), Expect = 1.740e-50
Identity = 75/119 (63.03%), Postives = 95/119 (79.83%), Query Frame = 2 
Query:   68 TRPWNPSFSHCDRERWICIYPIYLNSKRTISEGRKMSMKYCVENPKFDEIRDVLLEAGLQIGVEDKVHPKVQDSKESKSRGRIRVQLKNESGQPILEHFPDRISVLKYLGETIPKLKAR 424
             RPWN  FSH DRERW+CIYP+Y+NSK+T++EGR++ +   V+NP + EIRDV   AGL +GVE+KVHP+  DS+++KSRGRIRVQLKNE G P+ + FP R S+L YLGETIPKLK R
Sbjct:   11 ARPWNQEFSHADRERWVCIYPLYINSKKTLAEGRRVPLTKGVDNPLYSEIRDVCAAAGLTLGVENKVHPREMDSRDTKSRGRIRVQLKNEDGSPVNDKFPTRQSILLYLGETIPKLKGR 129
[Close]
BLAST of Signal recognition particle 19 kDa protein vs. TrEMBL
Match: A0A2A3E7A7 (Signal recognition particle OS=Apis cerana cerana OX=94128 GN=APICC_04278 PE=4 SV=1)

HSP 1 Score: 162.54 bits (410), Expect = 1.480e-47
Identity = 77/122 (63.11%), Postives = 91/122 (74.59%), Query Frame = 2 
Query:   65 MTRPWNPSFSHCDRERWICIYPIYLNSKRTISEGRKMSMKYCVENPKFDEIRDVLLEAGLQIGVEDKVHPKVQDSKESKSRGRIRVQLKNESGQPILEHFPDRISVLKYLGETIPKLKARQS 430
            M   WNPS  H DRERWICIYP+YLNSKRT++EGRK++   CVENP   EIRDVL+ AG  +GVE+K+HP+ + SKE   RGRIRVQLKN+ G P+   FP R SVL Y+G TIPKLK RQ 
Sbjct:    1 MALGWNPSKKHSDRERWICIYPVYLNSKRTLAEGRKLAKDKCVENPTHQEIRDVLVAAGFNVGVENKLHPR-ERSKELLYRGRIRVQLKNDDGTPVKSEFPTRDSVLAYVGTTIPKLKTRQG 121
[Close]
BLAST of Signal recognition particle 19 kDa protein vs. TrEMBL
Match: V9IGH9 (Signal recognition particle protein OS=Apis cerana OX=7461 GN=ACCB07727 PE=2 SV=1)

HSP 1 Score: 162.54 bits (410), Expect = 1.480e-47
Identity = 77/122 (63.11%), Postives = 91/122 (74.59%), Query Frame = 2 
Query:   65 MTRPWNPSFSHCDRERWICIYPIYLNSKRTISEGRKMSMKYCVENPKFDEIRDVLLEAGLQIGVEDKVHPKVQDSKESKSRGRIRVQLKNESGQPILEHFPDRISVLKYLGETIPKLKARQS 430
            M   WNPS  H DRERWICIYP+YLNSKRT++EGRK++   CVENP   EIRDVL+ AG  +GVE+K+HP+ + SKE   RGRIRVQLKN+ G P+   FP R SVL Y+G TIPKLK RQ 
Sbjct:    1 MALGWNPSKKHSDRERWICIYPVYLNSKRTLAEGRKLAKDKCVENPTHQEIRDVLVAAGFNVGVENKLHPR-ERSKELLYRGRIRVQLKNDDGTPVKSEFPTRDSVLAYVGTTIPKLKTRQG 121
[Close]
BLAST of Signal recognition particle 19 kDa protein vs. TrEMBL
Match: A0A088ATP6 (Uncharacterized protein OS=Apis mellifera OX=7460 GN=Srp19 PE=4 SV=1)

HSP 1 Score: 162.54 bits (410), Expect = 1.480e-47
Identity = 77/122 (63.11%), Postives = 91/122 (74.59%), Query Frame = 2 
Query:   65 MTRPWNPSFSHCDRERWICIYPIYLNSKRTISEGRKMSMKYCVENPKFDEIRDVLLEAGLQIGVEDKVHPKVQDSKESKSRGRIRVQLKNESGQPILEHFPDRISVLKYLGETIPKLKARQS 430
            M   WNPS  H DRERWICIYP+YLNSKRT++EGRK++   CVENP   EIRDVL+ AG  +GVE+K+HP+ + SKE   RGRIRVQLKN+ G P+   FP R SVL Y+G TIPKLK RQ 
Sbjct:    1 MALGWNPSKKHSDRERWICIYPVYLNSKRTLAEGRKLAKDKCVENPTHQEIRDVLVAAGFNVGVENKLHPR-ERSKELLYRGRIRVQLKNDDGTPVKSEFPTRDSVLAYVGTTIPKLKTRQG 121
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BLAST of Signal recognition particle 19 kDa protein vs. TrEMBL
Match: A0A026VX70 (Signal recognition particle 19 kDa protein OS=Ooceraea biroi OX=2015173 GN=DMN91_005924 PE=4 SV=1)

HSP 1 Score: 160.229 bits (404), Expect = 1.146e-46
Identity = 76/131 (58.02%), Postives = 96/131 (73.28%), Query Frame = 2 
Query:   65 MTRPWNPSFSHCDRERWICIYPIYLNSKRTISEGRKMSMKYCVENPKFDEIRDVLLEAGLQIGVEDKVHPKVQDSKESKSRGRIRVQLKNESGQPILEHFPDRISVLKYLGETIPKLKARQSISTPHGATS 457
            M+  WNP+  H +RERWICIYPIY+NSKR+++ GRK+S + CVENP   EIRDVL+ AG  +GVE+K+HPK + SKE   RGRIRVQL+N+ G P+   FP R SVL+Y+G TIPKLK RQ   +    TS
Sbjct:    1 MSLAWNPAKKHSERERWICIYPIYINSKRSLAGGRKLSKEKCVENPTHQEIRDVLVAAGFNVGVENKLHPK-ERSKEPVYRGRIRVQLRNDDGTPVRAEFPTRDSVLEYIGTTIPKLKTRQGKQSSSEQTS 130
[Close]
BLAST of Signal recognition particle 19 kDa protein vs. Ensembl Cavefish
Match: srp19 (signal recognition particle 19 [Source:NCBI gene;Acc:103034974])

HSP 1 Score: 103.605 bits (257), Expect = 3.973e-28
Identity = 52/115 (45.22%), Postives = 75/115 (65.22%), Query Frame = 2 
Query:   80 NPSFSHCDRERWICIYPIYLNSKRTISEGRKMSMKYCVENPKFDEIRDVLLEAGLQIGVEDKVHPKVQDSKESKSRGRIRVQLKNESGQPILEHFPDRISVLKYLGETIPKLKAR 424
            NP+    D  R++CIYP Y+NSK+T++EGR++ ++  VENP   EIRDVL  AG+ + VE+K++P+  +    + RGR+RVQ+K E      E F  R  V+ Y+ E IPKLK R
Sbjct:    7 NPA----DETRFLCIYPAYINSKKTLAEGRRIPIEKAVENPSCAEIRDVLTAAGMNVNVENKMYPREWN---REFRGRVRVQIKQEDDTLCQEKFASRKDVMFYVAEMIPKLKTR 114
[Close]
BLAST of Signal recognition particle 19 kDa protein vs. Ensembl Sea Lamprey
Match: srp19 (signal recognition particle 19 [Source:ZFIN;Acc:ZDB-GENE-040426-2657])

HSP 1 Score: 128.257 bits (321), Expect = 2.754e-38
Identity = 59/111 (53.15%), Postives = 83/111 (74.77%), Query Frame = 2 
Query:   98 CDRERWICIYPIYLNSKRTISEGRKMSMKYCVENPKFDEIRDVLLEAGLQIGVEDKVHPKVQDSKESKSRGRIRVQLKNESGQPILEHFPDRISVLKYLGETIPKLKARQS 430
             D+ER++CIYP YLNSK+TI+EGR++     VENP + EIRDVLL AG+ + VE+K++P+ + +++ + RGRIRVQLKNE G P+LE  P R ++  Y  + IPKLKAR +
Sbjct:    9 ADKERFVCIYPAYLNSKKTIAEGRRVPKDKAVENPTYVEIRDVLLAAGMNVVVENKMYPR-EWNRDVQFRGRIRVQLKNEDGSPVLEAIPTRQALFTYTADMIPKLKARTT 118
[Close]
BLAST of Signal recognition particle 19 kDa protein vs. Ensembl Nematostella
Match: EDO48060 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7RJY5])

HSP 1 Score: 102.064 bits (253), Expect = 7.854e-28
Identity = 46/110 (41.82%), Postives = 72/110 (65.45%), Query Frame = 2 
Query:  104 RERWICIYPIYLNSKRTISEGRKMSMKYCVENPKFDEIRDVLLEAGLQIGVE-DKVHPKVQDSKESKSRGRIRVQLKNESGQPILEHFPDRISVLKYLGETIPKLKARQS 430
            ++RW+ +YP YLNS+RT+ +GR++     V+NP   EIRD+     L   +E +K +PK + +K+   +GR+R+QLKN  G P+    P+R ++  +LGE IPKLK RQ+
Sbjct:   12 KDRWVTVYPAYLNSRRTVCQGRRVPKAKAVDNPTVSEIRDICTSQNLSCELENNKFYPK-ESAKDVVCKGRVRIQLKNSDGTPVNADIPNRKALFCFLGEMIPKLKTRQT 120
[Close]
BLAST of Signal recognition particle 19 kDa protein vs. Ensembl Medaka
Match: srp19 (signal recognition particle 19 [Source:NCBI gene;Acc:101157354])

HSP 1 Score: 109.383 bits (272), Expect = 2.327e-30
Identity = 51/108 (47.22%), Postives = 77/108 (71.30%), Query Frame = 2 
Query:  101 DRERWICIYPIYLNSKRTISEGRKMSMKYCVENPKFDEIRDVLLEAGLQIGVEDKVHPKVQDSKESKSRGRIRVQLKNESGQPILEHFPDRISVLKYLGETIPKLKAR 424
            D+ER++C+YP+Y+NSK+T++EGR++  +  VENP   EIRDVL  AG+ + VE+K+HP+ + +++ + RGR+RVQLK   G    + F  R  V+ Y+ E IPKLK R
Sbjct:   10 DKERFVCLYPVYINSKKTLAEGRRIPTEKAVENPSCGEIRDVLTAAGMNVYVENKMHPR-EWNRDVQFRGRVRVQLKQSDGSLCQDKFKCRKDVMVYVAEMIPKLKTR 116
[Close]
BLAST of Signal recognition particle 19 kDa protein vs. Ensembl Medaka
Match: srp19 (signal recognition particle 19 [Source:NCBI gene;Acc:101157354])

HSP 1 Score: 104.375 bits (259), Expect = 2.655e-28
Identity = 50/109 (45.87%), Postives = 75/109 (68.81%), Query Frame = 2 
Query:  110 RWICIYPIYLNSKRTISEGRKMSMKYCVENPKFDEIRDVLLEAGLQIGVEDKVHPKVQDSKESKSRGRIRVQLKNESGQPILEHFPDRISVLKYLGETIPKLKARQSIS 436
            R++C+YP+Y+NSK+T++EGR++  +  VENP   EIRDVL  AG+ + VE+K+HP+ + +++ + RGR+RVQLK   G    + F  R  V+ Y+ E IPKLK R   S
Sbjct:   21 RFVCLYPVYINSKKTLAEGRRIPTEKAVENPSCGEIRDVLTAAGMNVYVENKMHPR-EWNRDVQFRGRVRVQLKQSDGSLCQDKFKCRKDVMVYVAEMIPKLKTRTQKS 128
[Close]
BLAST of Signal recognition particle 19 kDa protein vs. Ensembl Medaka
Match: srp19 (signal recognition particle 19 [Source:NCBI gene;Acc:101157354])

HSP 1 Score: 72.4034 bits (176), Expect = 1.988e-16
Identity = 37/78 (47.44%), Postives = 51/78 (65.38%), Query Frame = 2 
Query:  191 VENPKFDEIRDVLLEAGLQIGVEDKVHPKVQDSKESKSRGRIRVQLKNESGQPILEHFPDRISVLKYLGETIPKLKAR 424
            VENP   EIRDVL  AG+ + VE+K+HP+ + +++ + RGR+RVQLK   G    + F  R  V+ Y+ E IPKLK R
Sbjct:    9 VENPSCGEIRDVLTAAGMNVYVENKMHPR-EWNRDVQFRGRVRVQLKQSDGSLCQDKFKCRKDVMVYVAEMIPKLKTR 85
[Close]
BLAST of Signal recognition particle 19 kDa protein vs. Planmine SMEST
Match: SMESG000006823.1 (SMESG000006823.1)

HSP 1 Score: 278.87 bits (712), Expect = 4.194e-97
Identity = 133/133 (100.00%), Postives = 133/133 (100.00%), Query Frame = 2 
Query:   65 MTRPWNPSFSHCDRERWICIYPIYLNSKRTISEGRKMSMKYCVENPKFDEIRDVLLEAGLQIGVEDKVHPKVQDSKESKSRGRIRVQLKNESGQPILEHFPDRISVLKYLGETIPKLKARQSISTPHGATSDV 463
            MTRPWNPSFSHCDRERWICIYPIYLNSKRTISEGRKMSMKYCVENPKFDEIRDVLLEAGLQIGVEDKVHPKVQDSKESKSRGRIRVQLKNESGQPILEHFPDRISVLKYLGETIPKLKARQSISTPHGATSDV
Sbjct:    1 MTRPWNPSFSHCDRERWICIYPIYLNSKRTISEGRKMSMKYCVENPKFDEIRDVLLEAGLQIGVEDKVHPKVQDSKESKSRGRIRVQLKNESGQPILEHFPDRISVLKYLGETIPKLKARQSISTPHGATSDV 133
The following BLAST results are available for this feature:
BLAST of Signal recognition particle 19 kDa protein vs. Ensembl Human
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Human e!99)
Total hits: 5
Match NameE-valueIdentityDescription
SRP195.746e-2846.85signal recognition particle 19 [Source:HGNC Symbol... [more]
SRP192.252e-2144.68signal recognition particle 19 [Source:HGNC Symbol... [more]
SRP192.392e-2144.68signal recognition particle 19 [Source:HGNC Symbol... [more]
SRP191.016e-2042.27signal recognition particle 19 [Source:HGNC Symbol... [more]
SRP194.207e-1738.74signal recognition particle 19 [Source:HGNC Symbol... [more]
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BLAST of Signal recognition particle 19 kDa protein vs. Ensembl Celegans
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99)
Total hits: 2
Match NameE-valueIdentityDescription
F37F2.27.820e-1942.20Probable signal recognition particle 19 kDa protei... [more]
F37F2.27.820e-1942.20Probable signal recognition particle 19 kDa protei... [more]
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BLAST of Signal recognition particle 19 kDa protein vs. Ensembl Fly
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99)
Total hits: 1
Match NameE-valueIdentityDescription
Srp195.959e-3345.97gene:FBgn0015298 transcript:FBtr0076879[more]
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BLAST of Signal recognition particle 19 kDa protein vs. Ensembl Zebrafish
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99)
Total hits: 1
Match NameE-valueIdentityDescription
srp195.700e-2845.22signal recognition particle 19 [Source:ZFIN;Acc:ZD... [more]
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BLAST of Signal recognition particle 19 kDa protein vs. Ensembl Xenopus
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99)
Total hits: 2
Match NameE-valueIdentityDescription
uso11.603e-2341.38USO1 vesicle transport factor [Source:Xenbase;Acc:... [more]
uso11.957e-2141.90USO1 vesicle transport factor [Source:Xenbase;Acc:... [more]
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BLAST of Signal recognition particle 19 kDa protein vs. Ensembl Mouse
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99)
Total hits: 3
Match NameE-valueIdentityDescription
Srp197.854e-2846.85signal recognition particle 19 [Source:MGI Symbol;... [more]
Srp191.871e-1738.74signal recognition particle 19 [Source:MGI Symbol;... [more]
Srp195.329e-656.67signal recognition particle 19 [Source:MGI Symbol;... [more]
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BLAST of Signal recognition particle 19 kDa protein vs. UniProt/SwissProt
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt)
Total hits: 5
Match NameE-valueIdentityDescription
sp|P49963|SRP19_DROME5.973e-3245.97Signal recognition particle 19 kDa protein OS=Dros... [more]
sp|Q3ZBG7|SRP19_BOVIN2.323e-2746.85Signal recognition particle 19 kDa protein OS=Bos ... [more]
sp|Q5RBR1|SRP19_PONAB2.759e-2746.85Signal recognition particle 19 kDa protein OS=Pong... [more]
sp|P09132|SRP19_HUMAN2.759e-2746.85Signal recognition particle 19 kDa protein OS=Homo... [more]
sp|Q9D7A6|SRP19_MOUSE7.945e-2546.30Signal recognition particle 19 kDa protein OS=Mus ... [more]
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BLAST of Signal recognition particle 19 kDa protein vs. TrEMBL
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL)
Total hits: 5
Match NameE-valueIdentityDescription
R7V1R51.740e-5063.03Uncharacterized protein OS=Capitella teleta OX=283... [more]
A0A2A3E7A71.480e-4763.11Signal recognition particle OS=Apis cerana cerana ... [more]
V9IGH91.480e-4763.11Signal recognition particle protein OS=Apis cerana... [more]
A0A088ATP61.480e-4763.11Uncharacterized protein OS=Apis mellifera OX=7460 ... [more]
A0A026VX701.146e-4658.02Signal recognition particle 19 kDa protein OS=Ooce... [more]
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BLAST of Signal recognition particle 19 kDa protein vs. Ensembl Cavefish
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99)
Total hits: 1
Match NameE-valueIdentityDescription
srp193.973e-2845.22signal recognition particle 19 [Source:NCBI gene;A... [more]
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BLAST of Signal recognition particle 19 kDa protein vs. Ensembl Sea Lamprey
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99)
Total hits: 1
Match NameE-valueIdentityDescription
srp192.754e-3853.15signal recognition particle 19 [Source:ZFIN;Acc:ZD... [more]
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BLAST of Signal recognition particle 19 kDa protein vs. Ensembl Yeast
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46)
Total hits: 0
Match NameE-valueIdentityDescription
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BLAST of Signal recognition particle 19 kDa protein vs. Ensembl Nematostella
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46)
Total hits: 1
Match NameE-valueIdentityDescription
EDO480607.854e-2841.82Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7... [more]
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BLAST of Signal recognition particle 19 kDa protein vs. Ensembl Medaka
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99)
Total hits: 3
Match NameE-valueIdentityDescription
srp192.327e-3047.22signal recognition particle 19 [Source:NCBI gene;A... [more]
srp192.655e-2845.87signal recognition particle 19 [Source:NCBI gene;A... [more]
srp191.988e-1647.44signal recognition particle 19 [Source:NCBI gene;A... [more]
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BLAST of Signal recognition particle 19 kDa protein vs. Planmine SMEST
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST)
Total hits: 1
Match NameE-valueIdentityDescription
SMESG000006823.14.194e-97100.00SMESG000006823.1[more]
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Sequences
The following sequences are available for this feature:

transcript sequence

>SMED30011729 ID=SMED30011729|Name=Signal recognition particle 19 kDa protein|organism=Schmidtea mediterranea sexual|type=transcript|length=619bp
CTTCAGATAAATAATAAAATTTAATTATTTTCGTGGCATTTAATTAATTA
TTTTTAAATTTTAAATGACTCGTCCATGGAATCCTAGTTTTAGTCACTGT
GACAGAGAGCGATGGATATGTATTTATCCAATTTATTTGAATTCAAAAAG
AACAATATCTGAAGGTCGAAAAATGTCAATGAAATATTGTGTTGAAAATC
CTAAATTTGATGAAATACGAGATGTCCTGTTAGAAGCTGGTTTACAAATC
GGAGTTGAAGATAAAGTTCATCCAAAAGTCCAAGATTCTAAAGAAAGTAA
ATCCAGAGGAAGGATCAGAGTTCAATTGAAAAATGAATCTGGACAACCTA
TTTTAGAACACTTCCCAGACAGAATTTCTGTGTTAAAATATCTAGGTGAA
ACTATTCCAAAATTGAAAGCAAGGCAAAGCATTTCGACGCCTCATGGTGC
TACAAGTGATGTTTCAAATTCTAAAAAGAATAAAAAACGAAAAAAATAAC
AATTTGAATTCAAATATAGATGTCGAATTTTTAAATTTCTCAAAATAATT
TTCCTTTAAAGTTCTATATAATTTTTGAACTAAATAAAGAATAAATCAAA
TTGTTATATGATGCTGAAC
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protein sequence of SMED30011729-orf-1

>SMED30011729-orf-1 ID=SMED30011729-orf-1|Name=SMED30011729-orf-1|organism=Schmidtea mediterranea sexual|type=polypeptide|length=145bp
MTRPWNPSFSHCDRERWICIYPIYLNSKRTISEGRKMSMKYCVENPKFDE
IRDVLLEAGLQIGVEDKVHPKVQDSKESKSRGRIRVQLKNESGQPILEHF
PDRISVLKYLGETIPKLKARQSISTPHGATSDVSNSKKNKKRKK*
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Annotated Terms
The following terms have been associated with this transcript:
Vocabulary: Planarian Anatomy
TermDefinition
PLANA:0002032epidermal cell
Vocabulary: INTERPRO
TermDefinition
IPR036521SRP19-like_sf
IPR002778Signal_recog_particle_SRP19
Vocabulary: molecular function
TermDefinition
GO:00083127S RNA binding
Vocabulary: biological process
TermDefinition
GO:0006614SRP-dependent cotranslational protein targeting to membrane
Vocabulary: cellular component
TermDefinition
GO:0048500signal recognition particle
InterPro
Analysis Name: Schmidtea mediteranean smed_20140614 Interproscan
Date Performed: 2020-05-01
IPR TermIPR DescriptionSourceSource TermSource DescriptionAlignment
IPR002778Signal recognition particle, SRP19 subunitPFAMPF01922SRP19coord: 19..116
e-value: 3.4E-23
score: 82.4
IPR002778Signal recognition particle, SRP19 subunitPANTHERPTHR17453SIGNAL RECOGNITION PARTICLE 19 KD PROTEINcoord: 14..142
IPR036521Signal recognition particle, subunit SRP19-like superfamilyGENE3DG3DSA:3.30.56.30coord: 8..127
e-value: 3.5E-36
score: 126.2
IPR036521Signal recognition particle, subunit SRP19-like superfamilySUPERFAMILYSSF69695SRP19coord: 9..119
NoneNo IPR availableMOBIDB_LITEmobidb-litedisorder_predictioncoord: 118..133
NoneNo IPR availableMOBIDB_LITEmobidb-litedisorder_predictioncoord: 118..144