Mitogen-activated protein kinase kinase kinase 3

Overview
NameMitogen-activated protein kinase kinase kinase 3
Smed IDSMED30011710
Length (bp)2283
Neoblast Clusters

Zeng et. al., 2018



▻ Overview

▻ Neoblast Population

▻ Sub-lethal Irradiated Surviving X1 and X2 Cell Population

 

 

Overview

 

Single cell RNA-seq of pluripotent neoblasts and its early progenies


We isolated X1 neoblasts cells enriched in high piwi-1 expression (Neoblast Population), and profiled ∼7,614 individual cells via scRNA-seq. Unsupervised analyses uncovered 12 distinct classes from 7,088 high-quality cells. We designated these classes Nb1 to Nb12 and ordered them based on high (Nb1) to low (Nb12) piwi-1 expression levels. We further defined groups of genes that best classified the cells parsed into 12 distinct cell clusters to generate a scaled expression heat map of discriminative gene sets for each cluster. Expression of each cluster’s gene signatures was validated using multiplex fluorescence in situ hybridization (FISH) co-stained with piwi-1 and largely confirmed the cell clusters revealed by scRNA-seq.

We also tested sub-lethal irradiation exposure. To profile rare pluripotent stem cells (PSCs) and avoid interference from immediate progenitor cells, we determined a time point after sub-lethal irradiation (7 DPI) with minimal piwi-1+ cells, followed by isolation and single-cell RNA-seq of 1,200 individual cells derived from X1 (Piwi-1 high) and X2 (Piwi-1 low) cell populations (Sub-lethal Irradiated Surviving X1 and X2 Cell Population)



Explore this single cell expression dataset with our NB Cluster Shiny App



 

Neoblast Population

 

t-SNE plot shows two-dimensional representation of global gene expression relationships among all neoblasts (n = 7,088 after filter). Cluster identity was assigned based on the top 10 marker genes of each cluster (Table S2), followed by inspection of RNA in situ hybridization patterns. Neoblast groups, Nb.


Expression of Mitogen-activated protein kinase kinase kinase 3 (SMED30011710) t-SNE clustered cells

Violin plots show distribution of expression levels for Mitogen-activated protein kinase kinase kinase 3 (SMED30011710) in cells (dots) of each of the 12 neoblast clusters.

 

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Sub-lethal Irradiated Surviving X1 and X2 Cell Population

 

t-SNE plot of surviving X1 and X2 cells (n = 1,039 after QC filter) after sub-lethal irradiation. Colors indicate unbiased cell classification via graph-based clustering. SL, sub-lethal irradiated cell groups.

Expression of Mitogen-activated protein kinase kinase kinase 3 (SMED30011710) in the t-SNE clustered sub-lethally irradiated X1 and X2 cells.

Violin plots show distribution of expression levels for Mitogen-activated protein kinase kinase kinase 3 (SMED30011710) in cells (dots) of each of the 10 clusters of sub-leathally irradiated X1 and X2 cells.

 

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Embryonic Expression

Davies et. al., 2017

Hover the mouse over a column in the graph to view average RPKM values per sample.
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Embryonic Stages: Y: yolk. S2-S8: Stages 2-8. C4: asexual adult. SX: virgin, sexually mature adult.
For further information about sample preparation and analysis for the single animal RNA-Seq experiment, please refer to the Materials and Methods

 

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Anatomical Expression

PAGE et. al., 2020



SMED30011710

has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGE



PAGE Curations: 6

  
Expressed InReference TranscriptGene ModelsPublished TranscriptTranscriptomePublicationSpecimenLifecycleEvidence
intestinal phagocyteSMED30011710SMESG000009500.1 PL08002B2G01ncbi_smed_estsPMID:23079596
Forsthoefel et al., 2012		FACS sorted cell population asexual adult cDNA to DNA expression microarray evidence
gutSMED30011710SMESG000009509.1 SMESG000009500.1 dd_Smed_v4_5138_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018		FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
epidermisSMED30011710SMESG000009509.1 SMESG000009500.1 dd_Smed_v4_5138_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018		FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
parenchymaSMED30011710SMESG000009509.1 SMESG000009500.1 dd_Smed_v4_5138_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018		FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
parenchymal cellSMED30011710SMESG000009509.1 SMESG000009500.1 dd_Smed_v4_5138_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018		FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
epidermisSMED30011710SMESG000009509.1 SMESG000009500.1 dd_Smed_v4_5138_0_1dd_Smed_v4PMID:28292427
Wurtzel et al., 2017		whole organism asexual adult single-cell RNA-sequencing evidence
Note: Hover over icons to view figure legend
Homology
[Close]
BLAST of Mitogen-activated protein kinase kinase kinase 3 vs. Ensembl Human
Match: MAP3K3 (mitogen-activated protein kinase kinase kinase 3 [Source:HGNC Symbol;Acc:HGNC:6855])

HSP 1 Score: 166.777 bits (421), Expect = 7.233e-43
Identity = 117/303 (38.61%), Postives = 170/303 (56.11%), Query Frame = 2 
Query: 1379 DSYFALRSGISYFSLSKLE-NIVNQDP-----------VGEGGFGKVYQCEDLATNKVMAVKEIKI-PKNKKLSDVTSAIK-EILTFSKLECHQRIIQYFDFFQ-KDEKTFCITMEYMANGSLSSYLEINGPLEEREIARISTQVLEGLLYLHNNQILHRDIKGGNIXXXXXXXXXXXXFGLSKCSEEI--SGWDFYTGILQSNVGTQNWTAPEVLNDEAYGLKADIWSFGATVVEMVVGERPYADYESVQLTFKLLTDKKIEFTPPKTMTRQLEEFIAWCLKPEPHERPTAQLLLNSDFIKL 2236
            D    LRS  S  +LS  E N+  + P           +G+G FG+VY C D+ T + +A K+++  P + + S   SA++ EI     L+ H+RI+QY+   + + EKT  I MEYM  GS+   L+  G L E    + + Q+LEG+ YLH+N I+HRDIKG NIL D   N KL DFG SK  + I  SG    TG ++S  GT  W +PEV++ E YG KAD+WS G TVVEM+  + P+A+YE++   FK+ T +      P  ++    +F+      E  +RP+A+ LL   F +L
Sbjct:  330 DPRGRLRSADSENALSVQERNVPTKSPSAPINWRRGKLLGQGAFGRVYLCYDVDTGRELASKQVQFDPDSPETSKEVSALECEIQLLKNLQ-HERIVQYYGCLRDRAEKTLTIFMEYMPGGSVKDQLKAYGALTESVTRKYTRQILEGMSYLHSNMIVHRDIKGANILRDSAGNVKLGDFGASKRLQTICMSG----TG-MRSVTGTPYWMSPEVISGEGYGRKADVWSLGCTVVEMLTEKPPWAEYEAMAAIFKIAT-QPTNPQLPSHISEHGRDFLRRIFV-EARQRPSAEELLTHHFAQL 624
[Close]
BLAST of Mitogen-activated protein kinase kinase kinase 3 vs. Ensembl Human
Match: MAP3K3 (mitogen-activated protein kinase kinase kinase 3 [Source:HGNC Symbol;Acc:HGNC:6855])

HSP 1 Score: 166.777 bits (421), Expect = 7.304e-43
Identity = 107/265 (40.38%), Postives = 157/265 (59.25%), Query Frame = 2 
Query: 1457 VGEGGFGKVYQCEDLATNKVMAVKEIKI-PKNKKLSDVTSAIK-EILTFSKLECHQRIIQYFDFFQ-KDEKTFCITMEYMANGSLSSYLEINGPLEEREIARISTQVLEGLLYLHNNQILHRDIKGGNIXXXXXXXXXXXXFGLSKCSEEI--SGWDFYTGILQSNVGTQNWTAPEVLNDEAYGLKADIWSFGATVVEMVVGERPYADYESVQLTFKLLTDKKIEFTPPKTMTRQLEEFIAWCLKPEPHERPTAQLLLNSDFIKL 2236
            +G+G FG+VY C D+ T + +A K+++  P + + S   SA++ EI     L+ H+RI+QY+   + + EKT  I MEYM  GS+   L+  G L E    + + Q+LEG+ YLH+N I+HRDIKG NIL D   N KL DFG SK  + I  SG    TG ++S  GT  W +PEV++ E YG KAD+WS G TVVEM+  + P+A+YE++   FK+ T +      P  ++    +F+      E  +RP+A+ LL   F +L
Sbjct:  364 LGQGAFGRVYLCYDVDTGRELASKQVQFDPDSPETSKEVSALECEIQLLKNLQ-HERIVQYYGCLRDRAEKTLTIFMEYMPGGSVKDQLKAYGALTESVTRKYTRQILEGMSYLHSNMIVHRDIKGANILRDSAGNVKLGDFGASKRLQTICMSG----TG-MRSVTGTPYWMSPEVISGEGYGRKADVWSLGCTVVEMLTEKPPWAEYEAMAAIFKIAT-QPTNPQLPSHISEHGRDFLRRIFV-EARQRPSAEELLTHHFAQL 620
[Close]
BLAST of Mitogen-activated protein kinase kinase kinase 3 vs. Ensembl Human
Match: MAP3K3 (mitogen-activated protein kinase kinase kinase 3 [Source:HGNC Symbol;Acc:HGNC:6855])

HSP 1 Score: 167.162 bits (422), Expect = 7.465e-43
Identity = 117/303 (38.61%), Postives = 170/303 (56.11%), Query Frame = 2 
Query: 1379 DSYFALRSGISYFSLSKLE-NIVNQDP-----------VGEGGFGKVYQCEDLATNKVMAVKEIKI-PKNKKLSDVTSAIK-EILTFSKLECHQRIIQYFDFFQ-KDEKTFCITMEYMANGSLSSYLEINGPLEEREIARISTQVLEGLLYLHNNQILHRDIKGGNIXXXXXXXXXXXXFGLSKCSEEI--SGWDFYTGILQSNVGTQNWTAPEVLNDEAYGLKADIWSFGATVVEMVVGERPYADYESVQLTFKLLTDKKIEFTPPKTMTRQLEEFIAWCLKPEPHERPTAQLLLNSDFIKL 2236
            D    LRS  S  +LS  E N+  + P           +G+G FG+VY C D+ T + +A K+++  P + + S   SA++ EI     L+ H+RI+QY+   + + EKT  I MEYM  GS+   L+  G L E    + + Q+LEG+ YLH+N I+HRDIKG NIL D   N KL DFG SK  + I  SG    TG ++S  GT  W +PEV++ E YG KAD+WS G TVVEM+  + P+A+YE++   FK+ T +      P  ++    +F+      E  +RP+A+ LL   F +L
Sbjct:  361 DPRGRLRSADSENALSVQERNVPTKSPSAPINWRRGKLLGQGAFGRVYLCYDVDTGRELASKQVQFDPDSPETSKEVSALECEIQLLKNLQ-HERIVQYYGCLRDRAEKTLTIFMEYMPGGSVKDQLKAYGALTESVTRKYTRQILEGMSYLHSNMIVHRDIKGANILRDSAGNVKLGDFGASKRLQTICMSG----TG-MRSVTGTPYWMSPEVISGEGYGRKADVWSLGCTVVEMLTEKPPWAEYEAMAAIFKIAT-QPTNPQLPSHISEHGRDFLRRIFV-EARQRPSAEELLTHHFAQL 655
[Close]
BLAST of Mitogen-activated protein kinase kinase kinase 3 vs. Ensembl Human
Match: MAP3K3 (mitogen-activated protein kinase kinase kinase 3 [Source:HGNC Symbol;Acc:HGNC:6855])

HSP 1 Score: 167.162 bits (422), Expect = 7.465e-43
Identity = 117/303 (38.61%), Postives = 170/303 (56.11%), Query Frame = 2 
Query: 1379 DSYFALRSGISYFSLSKLE-NIVNQDP-----------VGEGGFGKVYQCEDLATNKVMAVKEIKI-PKNKKLSDVTSAIK-EILTFSKLECHQRIIQYFDFFQ-KDEKTFCITMEYMANGSLSSYLEINGPLEEREIARISTQVLEGLLYLHNNQILHRDIKGGNIXXXXXXXXXXXXFGLSKCSEEI--SGWDFYTGILQSNVGTQNWTAPEVLNDEAYGLKADIWSFGATVVEMVVGERPYADYESVQLTFKLLTDKKIEFTPPKTMTRQLEEFIAWCLKPEPHERPTAQLLLNSDFIKL 2236
            D    LRS  S  +LS  E N+  + P           +G+G FG+VY C D+ T + +A K+++  P + + S   SA++ EI     L+ H+RI+QY+   + + EKT  I MEYM  GS+   L+  G L E    + + Q+LEG+ YLH+N I+HRDIKG NIL D   N KL DFG SK  + I  SG    TG ++S  GT  W +PEV++ E YG KAD+WS G TVVEM+  + P+A+YE++   FK+ T +      P  ++    +F+      E  +RP+A+ LL   F +L
Sbjct:  361 DPRGRLRSADSENALSVQERNVPTKSPSAPINWRRGKLLGQGAFGRVYLCYDVDTGRELASKQVQFDPDSPETSKEVSALECEIQLLKNLQ-HERIVQYYGCLRDRAEKTLTIFMEYMPGGSVKDQLKAYGALTESVTRKYTRQILEGMSYLHSNMIVHRDIKGANILRDSAGNVKLGDFGASKRLQTICMSG----TG-MRSVTGTPYWMSPEVISGEGYGRKADVWSLGCTVVEMLTEKPPWAEYEAMAAIFKIAT-QPTNPQLPSHISEHGRDFLRRIFV-EARQRPSAEELLTHHFAQL 655
[Close]
BLAST of Mitogen-activated protein kinase kinase kinase 3 vs. Ensembl Human
Match: MAP3K3 (mitogen-activated protein kinase kinase kinase 3 [Source:HGNC Symbol;Acc:HGNC:6855])

HSP 1 Score: 166.777 bits (421), Expect = 9.483e-43
Identity = 117/303 (38.61%), Postives = 170/303 (56.11%), Query Frame = 2 
Query: 1379 DSYFALRSGISYFSLSKLE-NIVNQDP-----------VGEGGFGKVYQCEDLATNKVMAVKEIKI-PKNKKLSDVTSAIK-EILTFSKLECHQRIIQYFDFFQ-KDEKTFCITMEYMANGSLSSYLEINGPLEEREIARISTQVLEGLLYLHNNQILHRDIKGGNIXXXXXXXXXXXXFGLSKCSEEI--SGWDFYTGILQSNVGTQNWTAPEVLNDEAYGLKADIWSFGATVVEMVVGERPYADYESVQLTFKLLTDKKIEFTPPKTMTRQLEEFIAWCLKPEPHERPTAQLLLNSDFIKL 2236
            D    LRS  S  +LS  E N+  + P           +G+G FG+VY C D+ T + +A K+++  P + + S   SA++ EI     L+ H+RI+QY+   + + EKT  I MEYM  GS+   L+  G L E    + + Q+LEG+ YLH+N I+HRDIKG NIL D   N KL DFG SK  + I  SG    TG ++S  GT  W +PEV++ E YG KAD+WS G TVVEM+  + P+A+YE++   FK+ T +      P  ++    +F+      E  +RP+A+ LL   F +L
Sbjct:  357 DPRGRLRSADSENALSVQERNVPTKSPSAPINWRRGKLLGQGAFGRVYLCYDVDTGRELASKQVQFDPDSPETSKEVSALECEIQLLKNLQ-HERIVQYYGCLRDRAEKTLTIFMEYMPGGSVKDQLKAYGALTESVTRKYTRQILEGMSYLHSNMIVHRDIKGANILRDSAGNVKLGDFGASKRLQTICMSG----TG-MRSVTGTPYWMSPEVISGEGYGRKADVWSLGCTVVEMLTEKPPWAEYEAMAAIFKIAT-QPTNPQLPSHISEHGRDFLRRIFV-EARQRPSAEELLTHHFAQL 651
[Close]
BLAST of Mitogen-activated protein kinase kinase kinase 3 vs. Ensembl Celegans
Match: nsy-1 (Mitogen-activated protein kinase kinase kinase nsy-1 [Source:UniProtKB/Swiss-Prot;Acc:Q21029])

HSP 1 Score: 143.28 bits (360), Expect = 1.031e-34
Identity = 100/269 (37.17%), Postives = 143/269 (53.16%), Query Frame = 2 
Query: 1457 VGEGGFGKVYQCEDLATNKVMAVKEIKIPKNKKLSDVTSAIKEILTFSKLECHQRIIQYF--DFFQKD--EKTFCITMEYMANGSLSSYLEIN-GPLEEREIARISTQVLEGLLYLHNNQILHRDIKGGNIXXXXXXXX-XXXXFGLSKCSEEISGWDFYTGILQSNVGTQNWTAPEVLN--DEAYGLKADIWSFGATVVEMVVGERPYADYESVQLTFKLLTDKKIEFTPPKTMTRQLEEFIAWCLKPEPHERPTAQLLLNSDFIKLN 2239
            +G+G +G VY   D+ T + + VKEI++   K   +V   ++EI   S L CH  I+QY   D   KD     F I ME++  GSLSS L    GP+ E  +     Q+LEGL YLH  +I+HRDIKG N+L++      K++DFG  K    ++G +  T   ++  GT  + APEV++     YG  ADIWSFG T+VEM  G  P+ + ++ Q     +   K     P  +T +   FI  C  PE  +RP+A+ LL   FI  N
Sbjct:  656 LGKGTYGTVYAARDMDTQRQIVVKEIEV---KYDEEVQPLMEEISLHSTL-CHANIVQYLGCDLVGKDGSNDHFLIFMEHVPGGSLSSLLRSKWGPMNENAMNYYGKQILEGLKYLHELKIVHRDIKGDNVLVNTYSGVCKISDFGTCK---RLAGLNPVT---ETFTGTLQYMAPEVIDHGQRGYGAPADIWSFGCTMVEMATGRPPFVEMQNPQAAMFRVGMFKTHPPIPTEITEKCRNFIKSCFLPEACDRPSAKDLLQDPFIYHN 914
[Close]
BLAST of Mitogen-activated protein kinase kinase kinase 3 vs. Ensembl Celegans
Match: nsy-1 (Mitogen-activated protein kinase kinase kinase nsy-1 [Source:UniProtKB/Swiss-Prot;Acc:Q21029])

HSP 1 Score: 142.895 bits (359), Expect = 1.184e-34
Identity = 100/269 (37.17%), Postives = 143/269 (53.16%), Query Frame = 2 
Query: 1457 VGEGGFGKVYQCEDLATNKVMAVKEIKIPKNKKLSDVTSAIKEILTFSKLECHQRIIQYF--DFFQKD--EKTFCITMEYMANGSLSSYLEIN-GPLEEREIARISTQVLEGLLYLHNNQILHRDIKGGNIXXXXXXXX-XXXXFGLSKCSEEISGWDFYTGILQSNVGTQNWTAPEVLN--DEAYGLKADIWSFGATVVEMVVGERPYADYESVQLTFKLLTDKKIEFTPPKTMTRQLEEFIAWCLKPEPHERPTAQLLLNSDFIKLN 2239
            +G+G +G VY   D+ T + + VKEI++   K   +V   ++EI   S L CH  I+QY   D   KD     F I ME++  GSLSS L    GP+ E  +     Q+LEGL YLH  +I+HRDIKG N+L++      K++DFG  K    ++G +  T   ++  GT  + APEV++     YG  ADIWSFG T+VEM  G  P+ + ++ Q     +   K     P  +T +   FI  C  PE  +RP+A+ LL   FI  N
Sbjct:  670 LGKGTYGTVYAARDMDTQRQIVVKEIEV---KYDEEVQPLMEEISLHSTL-CHANIVQYLGCDLVGKDGSNDHFLIFMEHVPGGSLSSLLRSKWGPMNENAMNYYGKQILEGLKYLHELKIVHRDIKGDNVLVNTYSGVCKISDFGTCK---RLAGLNPVT---ETFTGTLQYMAPEVIDHGQRGYGAPADIWSFGCTMVEMATGRPPFVEMQNPQAAMFRVGMFKTHPPIPTEITEKCRNFIKSCFLPEACDRPSAKDLLQDPFIYHN 928
[Close]
BLAST of Mitogen-activated protein kinase kinase kinase 3 vs. Ensembl Celegans
Match: gck-1 (Germinal center kinase 1 [Source:UniProtKB/Swiss-Prot;Acc:H2L099])

HSP 1 Score: 140.584 bits (353), Expect = 1.641e-34
Identity = 99/291 (34.02%), Postives = 159/291 (54.64%), Query Frame = 2 
Query: 1415 FSLSKLENIV---NQDPVGEGGFGKVYQCEDLATNKVMAVKEIKIPKNKKLSDVTSAIKEILTFSKLECHQRIIQYFDFFQKDEKTFCITMEYMANGSLSSYLEINGPLEEREIARISTQVLEGLLYLHNNQILHRDIKGGNIXXXXXXXXXXXXFGLS-KCSEEISGWDFYTGILQSNVGTQNWTAPEVLNDEAYGLKADIWSFGATVVEMVVGERPYADYESVQLTFKLLTDKKIEFTPPKTM-----TRQLEEFIAWCLKPEPHERPTAQLLLNSDFIKLNK*NLVLI 2260
            F+ SKL+  V    Q+ +G G FG+VY+  D  T +V+A+K I + + +   ++    +EI   S+ +  Q + +YF  F K  K + I MEY+  GS    L  +G L+E  IA I  ++L+GL YLH+ + +HRDIK  N+L+ +  + K+ADFG++ + +E +     +       VG+  W APE++   +Y  KADIWS G T +E+  GE P++D   +++ F       I   PP  +     ++  +EF+  CL  +P  RP+A  LL   FIK  K N +L+
Sbjct:    3 FANSKLDPEVIFTKQERIGRGSFGEVYKGIDNRTGRVVAIKIIDLEQAE--DEIEDIQQEIQVLSQCDS-QYVTKYFGSFLKGSKLWII-MEYLGGGSALD-LTKSGKLDESHIAVILREILKGLEYLHSERKIHRDIKAANVLVSEHGDVKVADFGVAGQLTETVKKRITF-------VGSPFWMAPELIKQSSYDYKADIWSLGITAIELANGEPPHSDLHPMRVLF------LIPKNPPPVLQGSQWSKPFKEFVEMCLNKDPENRPSASTLLKHQFIKRAKKNSILV 275
[Close]
BLAST of Mitogen-activated protein kinase kinase kinase 3 vs. Ensembl Celegans
Match: gck-1 (Germinal center kinase 1 [Source:UniProtKB/Swiss-Prot;Acc:H2L099])

HSP 1 Score: 139.043 bits (349), Expect = 4.971e-34
Identity = 94/277 (33.94%), Postives = 152/277 (54.87%), Query Frame = 2 
Query: 1448 QDPVGEGGFGKVYQCEDLATNKVMAVKEIKIPKNKKLSDVTSAIKEILTFSKLECHQRIIQYFDFFQKDEKTFCITMEYMANGSLSSYLEINGPLEEREIARISTQVLEGLLYLHNNQILHRDIKGGNIXXXXXXXXXXXXFGLS-KCSEEISGWDFYTGILQSNVGTQNWTAPEVLNDEAYGLKADIWSFGATVVEMVVGERPYADYESVQLTFKLLTDKKIEFTPPKTM-----TRQLEEFIAWCLKPEPHERPTAQLLLNSDFIKLNK*NLVLI 2260
            Q+ +G G FG+VY+  D  T +V+A+K I + + +   ++    +EI   S+ +  Q + +YF  F K  K + I MEY+  GS    L  +G L+E  IA I  ++L+GL YLH+ + +HRDIK  N+L+ +  + K+ADFG++ + +E +     +       VG+  W APE++   +Y  KADIWS G T +E+  GE P++D   +++ F       I   PP  +     ++  +EF+  CL  +P  RP+A  LL   FIK  K N +L+
Sbjct:   37 QERIGRGSFGEVYKGIDNRTGRVVAIKIIDLEQAE--DEIEDIQQEIQVLSQCDS-QYVTKYFGSFLKGSKLWII-MEYLGGGSALD-LTKSGKLDESHIAVILREILKGLEYLHSERKIHRDIKAANVLVSEHGDVKVADFGVAGQLTETVKKRITF-------VGSPFWMAPELIKQSSYDYKADIWSLGITAIELANGEPPHSDLHPMRVLF------LIPKNPPPVLQGSQWSKPFKEFVEMCLNKDPENRPSASTLLKHQFIKRAKKNSILV 295
[Close]
BLAST of Mitogen-activated protein kinase kinase kinase 3 vs. Ensembl Celegans
Match: gck-1 (Germinal center kinase 1 [Source:UniProtKB/Swiss-Prot;Acc:H2L099])

HSP 1 Score: 139.043 bits (349), Expect = 5.234e-34
Identity = 94/277 (33.94%), Postives = 152/277 (54.87%), Query Frame = 2 
Query: 1448 QDPVGEGGFGKVYQCEDLATNKVMAVKEIKIPKNKKLSDVTSAIKEILTFSKLECHQRIIQYFDFFQKDEKTFCITMEYMANGSLSSYLEINGPLEEREIARISTQVLEGLLYLHNNQILHRDIKGGNIXXXXXXXXXXXXFGLS-KCSEEISGWDFYTGILQSNVGTQNWTAPEVLNDEAYGLKADIWSFGATVVEMVVGERPYADYESVQLTFKLLTDKKIEFTPPKTM-----TRQLEEFIAWCLKPEPHERPTAQLLLNSDFIKLNK*NLVLI 2260
            Q+ +G G FG+VY+  D  T +V+A+K I + + +   ++    +EI   S+ +  Q + +YF  F K  K + I MEY+  GS    L  +G L+E  IA I  ++L+GL YLH+ + +HRDIK  N+L+ +  + K+ADFG++ + +E +     +       VG+  W APE++   +Y  KADIWS G T +E+  GE P++D   +++ F       I   PP  +     ++  +EF+  CL  +P  RP+A  LL   FIK  K N +L+
Sbjct:   22 QERIGRGSFGEVYKGIDNRTGRVVAIKIIDLEQAE--DEIEDIQQEIQVLSQCDS-QYVTKYFGSFLKGSKLWII-MEYLGGGSALD-LTKSGKLDESHIAVILREILKGLEYLHSERKIHRDIKAANVLVSEHGDVKVADFGVAGQLTETVKKRITF-------VGSPFWMAPELIKQSSYDYKADIWSLGITAIELANGEPPHSDLHPMRVLF------LIPKNPPPVLQGSQWSKPFKEFVEMCLNKDPENRPSASTLLKHQFIKRAKKNSILV 280
[Close]
BLAST of Mitogen-activated protein kinase kinase kinase 3 vs. Ensembl Fly
Match: Mekk1 (gene:FBgn0024329 transcript:FBtr0331353)

HSP 1 Score: 139.428 bits (350), Expect = 1.942e-33
Identity = 94/268 (35.07%), Postives = 144/268 (53.73%), Query Frame = 2 
Query: 1457 VGEGGFGKVYQCEDLATNKVMAVKEIKIP--KNKKLSDVTSAIKEILTFSKLECHQRIIQYFDFFQKDEKTFCITMEYMANGSLSSYLEINGPLEEREIARISTQVLEGLLYLHNNQILHRDIKGGNIXXXXXXXXXXXXFGLSKCSEEISGWDFYTGILQSNVGTQNWTAPEVL---NDEAYGLKADIWSFGATVVEMVVGERPYADYES-VQLTFKLLTDKKIEFTPPKTMTRQLEEFIAWCLKPEPHERPTAQLLLNSDFIKLNK 2242
            +G+G FGKVY   +  T ++MA+KEI I   + + L +V   +K IL   K   H+ +++Y+      E+   I ME  + G+L S +E+ G L E    R + Q+L G+  LH + I+HRDIK  NI       +     G    + +I       G LQ  VGTQ + APEV    N + +G  ADIWS G  VVEM  G+RP+A ++S  Q+ FK+   +K +   P++++++  +FI  CL+ +P  R TA  LL  +F K  +
Sbjct: 1195 IGQGRFGKVYTAVNNNTGELMAMKEIAIQPGETRALKNVAEELK-ILEGIK---HKNLVRYYGIEVHREE-LLIFMELCSEGTLESLVELTGNLPEALTRRFTAQLLSGVSELHKHGIVHRDIKTANI--FLVDGSNSLKLGDFGSAVKIQAHTTVPGELQGYVGTQAYMAPEVFTKTNSDGHGRAADIWSVGCVVVEMASGKRPWAQFDSNFQIMFKVGMGEKPQ--APESLSQEGHDFIDHCLQHDPKRRLTAVELLEHNFCKYGR 1453
[Close]
BLAST of Mitogen-activated protein kinase kinase kinase 3 vs. Ensembl Fly
Match: Mekk1 (gene:FBgn0024329 transcript:FBtr0083684)

HSP 1 Score: 139.428 bits (350), Expect = 2.099e-33
Identity = 94/268 (35.07%), Postives = 144/268 (53.73%), Query Frame = 2 
Query: 1457 VGEGGFGKVYQCEDLATNKVMAVKEIKIP--KNKKLSDVTSAIKEILTFSKLECHQRIIQYFDFFQKDEKTFCITMEYMANGSLSSYLEINGPLEEREIARISTQVLEGLLYLHNNQILHRDIKGGNIXXXXXXXXXXXXFGLSKCSEEISGWDFYTGILQSNVGTQNWTAPEVL---NDEAYGLKADIWSFGATVVEMVVGERPYADYES-VQLTFKLLTDKKIEFTPPKTMTRQLEEFIAWCLKPEPHERPTAQLLLNSDFIKLNK 2242
            +G+G FGKVY   +  T ++MA+KEI I   + + L +V   +K IL   K   H+ +++Y+      E+   I ME  + G+L S +E+ G L E    R + Q+L G+  LH + I+HRDIK  NI       +     G    + +I       G LQ  VGTQ + APEV    N + +G  ADIWS G  VVEM  G+RP+A ++S  Q+ FK+   +K +   P++++++  +FI  CL+ +P  R TA  LL  +F K  +
Sbjct: 1288 IGQGRFGKVYTAVNNNTGELMAMKEIAIQPGETRALKNVAEELK-ILEGIK---HKNLVRYYGIEVHREE-LLIFMELCSEGTLESLVELTGNLPEALTRRFTAQLLSGVSELHKHGIVHRDIKTANI--FLVDGSNSLKLGDFGSAVKIQAHTTVPGELQGYVGTQAYMAPEVFTKTNSDGHGRAADIWSVGCVVVEMASGKRPWAQFDSNFQIMFKVGMGEKPQ--APESLSQEGHDFIDHCLQHDPKRRLTAVELLEHNFCKYGR 1546
[Close]
BLAST of Mitogen-activated protein kinase kinase kinase 3 vs. Ensembl Fly
Match: GckIII (gene:FBgn0266465 transcript:FBtr0083399)

HSP 1 Score: 134.806 bits (338), Expect = 1.480e-32
Identity = 94/272 (34.56%), Postives = 151/272 (55.51%), Query Frame = 2 
Query: 1448 QDPVGEGGFGKVYQCEDLATNKVMAVKEIKIPKNKKLSDVTSAIKEILTFSKLECHQRIIQYFDFFQKDEKTFCITMEYMANGSLSSYLEINGPLEEREIARISTQVLEGLLYLHNNQILHRDIKGGNIXXXXXXXXXXXXFGLS-KCSEEISGWDFYTGILQSNVGTQNWTAPEVLNDEAYGLKADIWSFGATVVEMVVGERPYADYESVQLTFKLLTDKKIEFTPPKTMTRQLEEFIAWCLKPEPHERPTAQLLLNSDFIKLNK*NLVLI 2260
            Q+ +G+G FG+V++  D  T +V+A+K I + + +   ++    +EI+  S+ +    + +Y+  F K  K + I MEY+  GS    ++  G  EE  I  I  +VL+GL YLH+ + LHRDIK  N+LL ++ + KLADFG++ + +   S  + +       VGT  W APEV+    Y  KADIWS G T +E+  GE P ++   +++ F +  +   + T   + T+  ++F+  CL  +P  RPTA+ LL   FIK  K N  LI
Sbjct:   16 QERIGKGSFGEVFKGIDNRTQQVVAIKIIDLEEAE--DEIDDIQQEIMVLSQCDS-PYVTKYYGSFLKGTKLWII-MEYLGGGSALDLMKA-GSFEEMHIGIILREVLKGLDYLHSERKLHRDIKAANVLLSEQGDVKLADFGVAGQLTNTTSKRNTF-------VGTPFWMAPEVIKQSQYDAKADIWSLGITAIELAKGEPPNSELHPMRVLFLIPKNNPPQLT--GSYTKSFKDFVEACLNKDPENRPTAKELLKYPFIKKAKKNAYLI 273
[Close]
BLAST of Mitogen-activated protein kinase kinase kinase 3 vs. Ensembl Fly
Match: hpo (gene:FBgn0261456 transcript:FBtr0331920)

HSP 1 Score: 128.257 bits (321), Expect = 2.375e-30
Identity = 95/292 (32.53%), Postives = 152/292 (52.05%), Query Frame = 2 
Query: 1394 LRSGISYFSLSKL-ENIVNQDP---------VGEGGFGKVYQCEDLATNKVMAVKEIKIPKNKKLSDVTSAIKEILTFSKLECHQRIIQYFDFFQKDEKTFCITMEYMANGSLSSYLEINGP-LEEREIARISTQVLEGLLYLHNNQILHRDIKGGNIXXXXXXXXXXXXFGLS-KCSEEISGWDFYTGILQSNVGTQNWTAPEVLNDEAYGLKADIWSFGATVVEMVVGERPYADYESVQLTFKLLTDKKIEFTPPKTMTRQLEEFIAWCLKPEPHERPTAQLLLNSDFIK 2233
            + S  S+F L KL E  + Q P         +GEG +G VY+     ++ ++A+K + +      SD+   IKEI    + +    +  Y  +F++ +   C  MEY   GS+S  + +    L E EIA I +  L+GL+YLH  + +HRDIK  NILL+ +  AKLADFG++ + ++ ++  +       + +GT  W APEV+ +  Y   ADIWS G T +EM  G+ PY +   ++  F +       F  P   + +  +F++ CL  EP +R TA  LL  +FI+
Sbjct:   17 ISSSCSFFKLKKLSEESLLQPPEKVFDIMYKLGEGSYGSVYKAVHKESSSIVAIKLVPVE-----SDLHEIIKEISIMQQCDSPYVVRYYGSYFKQYDLWIC--MEYCGAGSVSDIMRLRKKTLTEDEIATILSDTLQGLVYLHLRRKIHRDIKAANILLNTEGYAKLADFGVAGQLTDTMAKRN-------TVIGTPFWMAPEVIEEIGYDCVADIWSLGITALEMAEGKPPYGEIHPMRAIFMIPQKPPPSFREPDRWSTEFIDFVSKCLVKEPDDRATATELLEHEFIR 294
[Close]
BLAST of Mitogen-activated protein kinase kinase kinase 3 vs. Ensembl Fly
Match: hpo (gene:FBgn0261456 transcript:FBtr0086500)

HSP 1 Score: 128.257 bits (321), Expect = 2.375e-30
Identity = 95/292 (32.53%), Postives = 152/292 (52.05%), Query Frame = 2 
Query: 1394 LRSGISYFSLSKL-ENIVNQDP---------VGEGGFGKVYQCEDLATNKVMAVKEIKIPKNKKLSDVTSAIKEILTFSKLECHQRIIQYFDFFQKDEKTFCITMEYMANGSLSSYLEINGP-LEEREIARISTQVLEGLLYLHNNQILHRDIKGGNIXXXXXXXXXXXXFGLS-KCSEEISGWDFYTGILQSNVGTQNWTAPEVLNDEAYGLKADIWSFGATVVEMVVGERPYADYESVQLTFKLLTDKKIEFTPPKTMTRQLEEFIAWCLKPEPHERPTAQLLLNSDFIK 2233
            + S  S+F L KL E  + Q P         +GEG +G VY+     ++ ++A+K + +      SD+   IKEI    + +    +  Y  +F++ +   C  MEY   GS+S  + +    L E EIA I +  L+GL+YLH  + +HRDIK  NILL+ +  AKLADFG++ + ++ ++  +       + +GT  W APEV+ +  Y   ADIWS G T +EM  G+ PY +   ++  F +       F  P   + +  +F++ CL  EP +R TA  LL  +FI+
Sbjct:   17 ISSSCSFFKLKKLSEESLLQPPEKVFDIMYKLGEGSYGSVYKAVHKESSSIVAIKLVPVE-----SDLHEIIKEISIMQQCDSPYVVRYYGSYFKQYDLWIC--MEYCGAGSVSDIMRLRKKTLTEDEIATILSDTLQGLVYLHLRRKIHRDIKAANILLNTEGYAKLADFGVAGQLTDTMAKRN-------TVIGTPFWMAPEVIEEIGYDCVADIWSLGITALEMAEGKPPYGEIHPMRAIFMIPQKPPPSFREPDRWSTEFIDFVSKCLVKEPDDRATATELLEHEFIR 294
[Close]
BLAST of Mitogen-activated protein kinase kinase kinase 3 vs. Ensembl Zebrafish
Match: map3k3 (mitogen-activated protein kinase kinase kinase 3 [Source:ZFIN;Acc:ZDB-GENE-070910-1])

HSP 1 Score: 165.236 bits (417), Expect = 1.077e-42
Identity = 102/262 (38.93%), Postives = 153/262 (58.40%), Query Frame = 2 
Query: 1457 VGEGGFGKVYQCEDLATNKVMAVKEIKI-PKNKKLSDVTSAIKEILTFSKLECHQRIIQYFDFFQ-KDEKTFCITMEYMANGSLSSYLEINGPLEEREIARISTQVLEGLLYLHNNQILHRDIKGGNIXXXXXXXXXXXXFGLSKCSEEISGWDFYTGILQSNVGTQNWTAPEVLNDEAYGLKADIWSFGATVVEMVVGERPYADYESVQLTFKLLTDKKIEFTPPKTMTRQLEEFIAWCLKPEPHERPTAQLLLNSDFIKL 2236
            +G+G FG+VY C D+ T + +A K++   P + + S   SA++  +   K   H+RI+QY+   +  +EKT  I MEYM  GS+   L+  G L E    + + Q+LEG+ YLH+N I+HRDIKG NIL D   N KL DFG SK  + I      TG+ +S  GT  W +PEV++ E YG KAD+WS G TVVEM+  + P+A++E++   FK+ T +      P  ++    +F+  C+  E   RP+A+ LL   F ++
Sbjct:  350 LGQGAFGRVYLCYDVDTGRELAAKQVHFDPASPETSKEVSALECEIQLLKNLHHERIVQYYGCLRDHNEKTLTIFMEYMPGGSVKDQLKAYGALTENVTRKYTRQILEGMSYLHSNMIVHRDIKGANILRDSAGNVKLGDFGASKRLQTICMSS--TGV-RSVTGTPYWMSPEVISGEGYGRKADVWSLGCTVVEMLTEKPPWAEFEAMAAIFKIAT-QPTNPQLPSHISEHTRDFLR-CIFVEAKYRPSAEELLRHPFSQI 606
[Close]
BLAST of Mitogen-activated protein kinase kinase kinase 3 vs. Ensembl Zebrafish
Match: map3k2 (mitogen-activated protein kinase kinase kinase 2 [Source:ZFIN;Acc:ZDB-GENE-120215-96])

HSP 1 Score: 165.236 bits (417), Expect = 1.252e-42
Identity = 105/262 (40.08%), Postives = 151/262 (57.63%), Query Frame = 2 
Query: 1457 VGEGGFGKVYQCEDLATNKVMAVKEIKI-PKNKKLSDVTSAIKEILTFSKLECHQRIIQYFDFFQK-DEKTFCITMEYMANGSLSSYLEINGPLEEREIARISTQVLEGLLYLHNNQILHRDIKGGNIXXXXXXXXXXXXFGLSKCSEEI--SGWDFYTGILQSNVGTQNWTAPEVLNDEAYGLKADIWSFGATVVEMVVGERPYADYESVQLTFKLLTDKKIEFTPPKTMTRQLEEFIAWCLKPEPHERPTAQLLLNSDFI 2230
            +G+G FG+V+ C D  T + +AVK+++  P + + S   SA++  +   K   H+RI+QY+   +   EKT  I MEYM  GS+   L+  G L E    + + Q+LEG+ YLH+N I+HRDIKG NIL D   N KL DFG S+  + I  SG    TGI +S  GT  W +PEV++ E YG KADIWS G TVVEM+    P+A++E++   FK+ T       PP  ++    +F+      E  +RP A+ LL   F+
Sbjct:  368 LGQGAFGRVFLCYDADTGRELAVKQVQFDPDSPETSKEVSALECEIQLLKNLFHERIVQYYGCLRDTHEKTLSIFMEYMPGGSIKDQLKSYGALTENVTRKYTRQILEGVCYLHSNMIVHRDIKGANILRDSAGNVKLGDFGASRRLQTICLSG----TGI-KSVTGTPYWMSPEVISGEGYGRKADIWSIGCTVVEMLTQRPPWAEFEAMAAIFKIATQPTNPTLPPH-VSDHCRDFLKRIFV-ETKQRPAAEDLLRHTFV 622
[Close]
BLAST of Mitogen-activated protein kinase kinase kinase 3 vs. Ensembl Zebrafish
Match: map3k2 (mitogen-activated protein kinase kinase kinase 2 [Source:ZFIN;Acc:ZDB-GENE-120215-96])

HSP 1 Score: 165.236 bits (417), Expect = 1.276e-42
Identity = 105/262 (40.08%), Postives = 151/262 (57.63%), Query Frame = 2 
Query: 1457 VGEGGFGKVYQCEDLATNKVMAVKEIKI-PKNKKLSDVTSAIKEILTFSKLECHQRIIQYFDFFQK-DEKTFCITMEYMANGSLSSYLEINGPLEEREIARISTQVLEGLLYLHNNQILHRDIKGGNIXXXXXXXXXXXXFGLSKCSEEI--SGWDFYTGILQSNVGTQNWTAPEVLNDEAYGLKADIWSFGATVVEMVVGERPYADYESVQLTFKLLTDKKIEFTPPKTMTRQLEEFIAWCLKPEPHERPTAQLLLNSDFI 2230
            +G+G FG+V+ C D  T + +AVK+++  P + + S   SA++  +   K   H+RI+QY+   +   EKT  I MEYM  GS+   L+  G L E    + + Q+LEG+ YLH+N I+HRDIKG NIL D   N KL DFG S+  + I  SG    TGI +S  GT  W +PEV++ E YG KADIWS G TVVEM+    P+A++E++   FK+ T       PP  ++    +F+      E  +RP A+ LL   F+
Sbjct:  360 LGQGAFGRVFLCYDADTGRELAVKQVQFDPDSPETSKEVSALECEIQLLKNLFHERIVQYYGCLRDTHEKTLSIFMEYMPGGSIKDQLKSYGALTENVTRKYTRQILEGVCYLHSNMIVHRDIKGANILRDSAGNVKLGDFGASRRLQTICLSG----TGI-KSVTGTPYWMSPEVISGEGYGRKADIWSIGCTVVEMLTQRPPWAEFEAMAAIFKIATQPTNPTLPPH-VSDHCRDFLKRIFV-ETKQRPAAEDLLRHTFV 614
[Close]
BLAST of Mitogen-activated protein kinase kinase kinase 3 vs. Ensembl Zebrafish
Match: map3k3 (mitogen-activated protein kinase kinase kinase 3 [Source:ZFIN;Acc:ZDB-GENE-070910-1])

HSP 1 Score: 165.236 bits (417), Expect = 1.405e-42
Identity = 102/262 (38.93%), Postives = 153/262 (58.40%), Query Frame = 2 
Query: 1457 VGEGGFGKVYQCEDLATNKVMAVKEIKI-PKNKKLSDVTSAIKEILTFSKLECHQRIIQYFDFFQ-KDEKTFCITMEYMANGSLSSYLEINGPLEEREIARISTQVLEGLLYLHNNQILHRDIKGGNIXXXXXXXXXXXXFGLSKCSEEISGWDFYTGILQSNVGTQNWTAPEVLNDEAYGLKADIWSFGATVVEMVVGERPYADYESVQLTFKLLTDKKIEFTPPKTMTRQLEEFIAWCLKPEPHERPTAQLLLNSDFIKL 2236
            +G+G FG+VY C D+ T + +A K++   P + + S   SA++  +   K   H+RI+QY+   +  +EKT  I MEYM  GS+   L+  G L E    + + Q+LEG+ YLH+N I+HRDIKG NIL D   N KL DFG SK  + I      TG+ +S  GT  W +PEV++ E YG KAD+WS G TVVEM+  + P+A++E++   FK+ T +      P  ++    +F+  C+  E   RP+A+ LL   F ++
Sbjct:  362 LGQGAFGRVYLCYDVDTGRELAAKQVHFDPASPETSKEVSALECEIQLLKNLHHERIVQYYGCLRDHNEKTLTIFMEYMPGGSVKDQLKAYGALTENVTRKYTRQILEGMSYLHSNMIVHRDIKGANILRDSAGNVKLGDFGASKRLQTICMSS--TGV-RSVTGTPYWMSPEVISGEGYGRKADVWSLGCTVVEMLTEKPPWAEFEAMAAIFKIAT-QPTNPQLPSHISEHTRDFLR-CIFVEAKYRPSAEELLRHPFSQI 618
[Close]
BLAST of Mitogen-activated protein kinase kinase kinase 3 vs. Ensembl Zebrafish
Match: map3k3 (mitogen-activated protein kinase kinase kinase 3 [Source:ZFIN;Acc:ZDB-GENE-070910-1])

HSP 1 Score: 165.236 bits (417), Expect = 1.578e-42
Identity = 102/262 (38.93%), Postives = 153/262 (58.40%), Query Frame = 2 
Query: 1457 VGEGGFGKVYQCEDLATNKVMAVKEIKI-PKNKKLSDVTSAIKEILTFSKLECHQRIIQYFDFFQ-KDEKTFCITMEYMANGSLSSYLEINGPLEEREIARISTQVLEGLLYLHNNQILHRDIKGGNIXXXXXXXXXXXXFGLSKCSEEISGWDFYTGILQSNVGTQNWTAPEVLNDEAYGLKADIWSFGATVVEMVVGERPYADYESVQLTFKLLTDKKIEFTPPKTMTRQLEEFIAWCLKPEPHERPTAQLLLNSDFIKL 2236
            +G+G FG+VY C D+ T + +A K++   P + + S   SA++  +   K   H+RI+QY+   +  +EKT  I MEYM  GS+   L+  G L E    + + Q+LEG+ YLH+N I+HRDIKG NIL D   N KL DFG SK  + I      TG+ +S  GT  W +PEV++ E YG KAD+WS G TVVEM+  + P+A++E++   FK+ T +      P  ++    +F+  C+  E   RP+A+ LL   F ++
Sbjct:  368 LGQGAFGRVYLCYDVDTGRELAAKQVHFDPASPETSKEVSALECEIQLLKNLHHERIVQYYGCLRDHNEKTLTIFMEYMPGGSVKDQLKAYGALTENVTRKYTRQILEGMSYLHSNMIVHRDIKGANILRDSAGNVKLGDFGASKRLQTICMSS--TGV-RSVTGTPYWMSPEVISGEGYGRKADVWSLGCTVVEMLTEKPPWAEFEAMAAIFKIAT-QPTNPQLPSHISEHTRDFLR-CIFVEAKYRPSAEELLRHPFSQI 624
[Close]
BLAST of Mitogen-activated protein kinase kinase kinase 3 vs. Ensembl Xenopus
Match: samd8 (sterile alpha motif domain containing 8 [Source:Xenbase;Acc:XB-GENE-1012742])

HSP 1 Score: 177.178 bits (448), Expect = 1.463e-46
Identity = 112/264 (42.42%), Postives = 156/264 (59.09%), Query Frame = 2 
Query: 1457 VGEGGFGKVYQCEDLATNKVMAVKEIKI-PKNKKLSDVTSAIKEILTFSKLECHQRIIQYFDFFQ-KDEKTFCITMEYMANGSLSSYLEINGPLEEREIARISTQVLEGLLYLHNNQILHRDIKGGNIXXXXXXXXXXXXFGLSKCSEEI--SGWDFYTGILQSNVGTQNWTAPEVLNDEAYGLKADIWSFGATVVEMVVGERPYADYESVQLTFKLLTDKKIEFTPPKTMTRQLEEFIAWCLKPEPHERPTAQLLLNSDFIKL 2236
            +G+G FG+VY C D+ T + +A K+++  P + + S   SA++  +   K   H RI+QY+   + K EKT  I MEYM  GS+   L+  G L E    R + Q+LEG+ YLH+N I+HRDIKG NIL D   N KL DFG SK  + I  SG    TGI +S  GT  W +PEV++ E YG KAD+WS G TVVEM+  + P+A+YE++   FK+ T       PP T + Q  +F+   L  E  +RPTA+ L+   F +L
Sbjct:  353 LGQGAFGRVYLCYDVDTGRELAAKQVQFDPDSPETSKEVSALECEIQLLKNLHHDRIVQYYGSLRDKGEKTLTIFMEYMPGGSVKDQLKAYGALTENVTRRYTRQILEGVSYLHSNMIVHRDIKGANILRDSAGNVKLGDFGASKRLQTICMSG----TGI-RSVTGTPYWMSPEVISGEGYGRKADVWSLGCTVVEMLTEKPPWAEYEAMAAIFKIATQPTNPQLPPNT-SEQCRDFVKRILV-EARQRPTAEELIRHPFAQL 609
[Close]
BLAST of Mitogen-activated protein kinase kinase kinase 3 vs. Ensembl Xenopus
Match: samd8 (sterile alpha motif domain containing 8 [Source:Xenbase;Acc:XB-GENE-1012742])

HSP 1 Score: 176.792 bits (447), Expect = 2.108e-46
Identity = 112/264 (42.42%), Postives = 156/264 (59.09%), Query Frame = 2 
Query: 1457 VGEGGFGKVYQCEDLATNKVMAVKEIKI-PKNKKLSDVTSAIKEILTFSKLECHQRIIQYFDFFQ-KDEKTFCITMEYMANGSLSSYLEINGPLEEREIARISTQVLEGLLYLHNNQILHRDIKGGNIXXXXXXXXXXXXFGLSKCSEEI--SGWDFYTGILQSNVGTQNWTAPEVLNDEAYGLKADIWSFGATVVEMVVGERPYADYESVQLTFKLLTDKKIEFTPPKTMTRQLEEFIAWCLKPEPHERPTAQLLLNSDFIKL 2236
            +G+G FG+VY C D+ T + +A K+++  P + + S   SA++  +   K   H RI+QY+   + K EKT  I MEYM  GS+   L+  G L E    R + Q+LEG+ YLH+N I+HRDIKG NIL D   N KL DFG SK  + I  SG    TGI +S  GT  W +PEV++ E YG KAD+WS G TVVEM+  + P+A+YE++   FK+ T       PP T + Q  +F+   L  E  +RPTA+ L+   F +L
Sbjct:  371 LGQGAFGRVYLCYDVDTGRELAAKQVQFDPDSPETSKEVSALECEIQLLKNLHHDRIVQYYGSLRDKGEKTLTIFMEYMPGGSVKDQLKAYGALTENVTRRYTRQILEGVSYLHSNMIVHRDIKGANILRDSAGNVKLGDFGASKRLQTICMSG----TGI-RSVTGTPYWMSPEVISGEGYGRKADVWSLGCTVVEMLTEKPPWAEYEAMAAIFKIATQPTNPQLPPNT-SEQCRDFVKRILV-EARQRPTAEELIRHPFAQL 627
[Close]
BLAST of Mitogen-activated protein kinase kinase kinase 3 vs. Ensembl Xenopus
Match: MAP3K2 (mitogen-activated protein kinase kinase kinase 2 [Source:NCBI gene;Acc:100493570])

HSP 1 Score: 158.303 bits (399), Expect = 3.082e-40
Identity = 103/265 (38.87%), Postives = 153/265 (57.74%), Query Frame = 2 
Query: 1457 VGEGGFGKVYQCEDLATNKVMAVKEIKI-PKNKKLSDVTSAIKEILTFSKLECHQRIIQYFDFFQ-KDEKTFCITMEYMANGSLSSYLEINGPLEEREIARISTQVLEGLLYLHNNQILHRDIKGGNIXXXXXXXXXXXXFGLSKCSEEI--SGWDFYTGILQSNVGTQNWTAPEVLNDEAYGLKADIWSFGATVVEMVVGERPYADYESVQLTFKLLTDKKIEFTPPKTMTRQLEEFIAWCLKPEPHERPTAQLLLNSDFIKLN 2239
            +G+G FG+VY C D  T + +AVK+++  P + + S   +A++  +   K   H+RI+QY+   +   EKT  I MEYM  GS+   L+  G L E    + + Q+LEG+ YLH+N I+HRDIKG NIL D   N KL DFG SK  + I  SG    TG ++S  GT  W +PEV++ E YG KADIWS G TVVEM+  + P+A++E++   FK+ T +      P  ++    +F+      E   RP+++ LL   F + +
Sbjct:  345 LGQGAFGRVYLCYDADTGRELAVKQVQFDPDSLETSKEVNALECEIQLLKNLLHERIVQYYGCLRDSQEKTLSIFMEYMPGGSIKDQLKAYGALTEFVTRKYTRQILEGVHYLHSNMIVHRDIKGANILRDSSGNVKLGDFGASKRLQTICLSG----TG-MKSVTGTPYWMSPEVISGEGYGRKADIWSVGCTVVEMLTEKPPWAEFEAMAAIFKIAT-QPTNPQLPAHVSEHCRDFLKRIFV-EAKVRPSSEELLRHTFAQYH 602
[Close]
BLAST of Mitogen-activated protein kinase kinase kinase 3 vs. Ensembl Xenopus
Match: MAP3K2 (mitogen-activated protein kinase kinase kinase 2 [Source:NCBI gene;Acc:100493570])

HSP 1 Score: 158.303 bits (399), Expect = 4.754e-40
Identity = 103/265 (38.87%), Postives = 153/265 (57.74%), Query Frame = 2 
Query: 1457 VGEGGFGKVYQCEDLATNKVMAVKEIKI-PKNKKLSDVTSAIKEILTFSKLECHQRIIQYFDFFQ-KDEKTFCITMEYMANGSLSSYLEINGPLEEREIARISTQVLEGLLYLHNNQILHRDIKGGNIXXXXXXXXXXXXFGLSKCSEEI--SGWDFYTGILQSNVGTQNWTAPEVLNDEAYGLKADIWSFGATVVEMVVGERPYADYESVQLTFKLLTDKKIEFTPPKTMTRQLEEFIAWCLKPEPHERPTAQLLLNSDFIKLN 2239
            +G+G FG+VY C D  T + +AVK+++  P + + S   +A++  +   K   H+RI+QY+   +   EKT  I MEYM  GS+   L+  G L E    + + Q+LEG+ YLH+N I+HRDIKG NIL D   N KL DFG SK  + I  SG    TG ++S  GT  W +PEV++ E YG KADIWS G TVVEM+  + P+A++E++   FK+ T +      P  ++    +F+      E   RP+++ LL   F + +
Sbjct:  373 LGQGAFGRVYLCYDADTGRELAVKQVQFDPDSLETSKEVNALECEIQLLKNLLHERIVQYYGCLRDSQEKTLSIFMEYMPGGSIKDQLKAYGALTEFVTRKYTRQILEGVHYLHSNMIVHRDIKGANILRDSSGNVKLGDFGASKRLQTICLSG----TG-MKSVTGTPYWMSPEVISGEGYGRKADIWSVGCTVVEMLTEKPPWAEFEAMAAIFKIAT-QPTNPQLPAHVSEHCRDFLKRIFV-EAKVRPSSEELLRHTFAQYH 630
[Close]
BLAST of Mitogen-activated protein kinase kinase kinase 3 vs. Ensembl Xenopus
Match: dennd1a (DENN domain containing 1A [Source:Xenbase;Acc:XB-GENE-5729862])

HSP 1 Score: 157.532 bits (397), Expect = 7.403e-40
Identity = 102/262 (38.93%), Postives = 151/262 (57.63%), Query Frame = 2 
Query: 1457 VGEGGFGKVYQCEDLATNKVMAVKEIKI-PKNKKLSDVTSAIKEILTFSKLECHQRIIQYFDFFQK-DEKTFCITMEYMANGSLSSYLEINGPLEEREIARISTQVLEGLLYLHNNQILHRDIKGGNIXXXXXXXXXXXXFGLSKCSEEI--SGWDFYTGILQSNVGTQNWTAPEVLNDEAYGLKADIWSFGATVVEMVVGERPYADYESVQLTFKLLTDKKIEFTPPKTMTRQLEEFIAWCLKPEPHERPTAQLLLNSDFI 2230
            +G G FG+VY C D+   + +AVK++   P +++ S   +A++  +   KL  H+RI+QY+   +   E+   I +EYM  GS+   L+  G L E    R + Q+L+G+ YLH N I+HRDIKG NIL D   N KL DFG SK  + I  SG    TGI +S  GT  W +PEV++ E YG KAD+WS   TVVEM+  + P+++YE++   FK+ T +  +   P T++    +F+      E   RPTA+ LL   F+
Sbjct:  360 LGRGAFGEVYLCYDVDKGRELAVKQVPFDPDSQETSKEVNALECEIQLLKLHRHERIVQYYGCLRDPTERKLSIFVEYMPGGSIKDQLKAYGALTENVTRRYTRQILQGVSYLHGNMIVHRDIKGANILRDSAGNVKLGDFGASKRIQTICMSG----TGI-KSVTGTPYWMSPEVISGEGYGRKADVWSVACTVVEMLTEKPPWSEYEAMAAIFKIAT-QPTKPRLPDTVSDACRDFMKQIFV-EEKRRPTAEELLRHLFV 614
[Close]
BLAST of Mitogen-activated protein kinase kinase kinase 3 vs. Ensembl Mouse
Match: Map3k3 (mitogen-activated protein kinase kinase kinase 3 [Source:MGI Symbol;Acc:MGI:1346874])

HSP 1 Score: 165.236 bits (417), Expect = 1.595e-42
Identity = 107/265 (40.38%), Postives = 156/265 (58.87%), Query Frame = 2 
Query: 1457 VGEGGFGKVYQCEDLATNKVMAVKEIKI-PKNKKLSDVTSAIK-EILTFSKLECHQRIIQYFDFFQ-KDEKTFCITMEYMANGSLSSYLEINGPLEEREIARISTQVLEGLLYLHNNQILHRDIKGGNIXXXXXXXXXXXXFGLSKCSEEI--SGWDFYTGILQSNVGTQNWTAPEVLNDEAYGLKADIWSFGATVVEMVVGERPYADYESVQLTFKLLTDKKIEFTPPKTMTRQLEEFIAWCLKPEPHERPTAQLLLNSDFIKL 2236
            +G+G FG+VY C D+ T + +A K+++  P + + S   SA++ EI     L+ H+RI+QY+   + + EK   I MEYM  GS+   L+  G L E    + + Q+LEG+ YLH+N I+HRDIKG NIL D   N KL DFG SK  + I  SG    TGI +S  GT  W +PEV++ E YG KAD+WS G TVVEM+  + P+A+YE++   FK+ T +      P  ++    +F+      E  +RP+A+ LL   F +L
Sbjct:  368 LGQGAFGRVYLCYDVDTGRELASKQVQFDPDSPETSKEVSALECEIQLLKNLQ-HERIVQYYGCLRDRAEKILTIFMEYMPGGSVKDQLKAYGALTESVTRKYTRQILEGMSYLHSNMIVHRDIKGANILRDSAGNVKLGDFGASKRLQTICMSG----TGI-RSVTGTPYWMSPEVISGEGYGRKADVWSLGCTVVEMLTEKPPWAEYEAMAAIFKIAT-QPTNPQLPSHISEHGRDFLRRIFV-EARQRPSAEELLTHHFAQL 624
[Close]
BLAST of Mitogen-activated protein kinase kinase kinase 3 vs. Ensembl Mouse
Match: Map3k2 (mitogen-activated protein kinase kinase kinase 2 [Source:MGI Symbol;Acc:MGI:1346873])

HSP 1 Score: 160.999 bits (406), Expect = 3.712e-41
Identity = 104/262 (39.69%), Postives = 153/262 (58.40%), Query Frame = 2 
Query: 1457 VGEGGFGKVYQCEDLATNKVMAVKEIKI-PKNKKLSDVTSAIKEILTFSKLECHQRIIQYFDFFQ-KDEKTFCITMEYMANGSLSSYLEINGPLEEREIARISTQVLEGLLYLHNNQILHRDIKGGNIXXXXXXXXXXXXFGLSKCSEEI--SGWDFYTGILQSNVGTQNWTAPEVLNDEAYGLKADIWSFGATVVEMVVGERPYADYESVQLTFKLLTDKKIEFTPPKTMTRQLEEFIAWCLKPEPHERPTAQLLLNSDFI 2230
            +G+G FG+VY C D+ T + +AVK+++  P++ + S   +A++  +   K   H+RI+QY+   +   EKT  I MEYM  GS+   L+  G L E    + + Q+LEG+ YLH+N I+HRDIKG NIL D   N KL DFG SK  + I  SG    TG ++S  GT  W +PEV++ E YG KADIWS   TVVEM+  + P+A++E++   FK+ T       PP  ++    +F+      E   RP+A+ LL   F+
Sbjct:  362 LGQGAFGRVYLCYDVDTGRELAVKQVQFNPESPETSKEVNALECEIQLLKNLLHERIVQYYGCLRDPQEKTLSIFMEYMPGGSIKDQLKAYGALTENVTRKYTRQILEGVHYLHSNMIVHRDIKGANILRDSTGNIKLGDFGASKRLQTICLSG----TG-MKSVTGTPYWMSPEVISGEGYGRKADIWSVACTVVEMLTEKPPWAEFEAMAAIFKIATQPTNPKLPPH-VSDYTRDFLKRIFV-EAKLRPSAEELLRHMFV 616
[Close]
BLAST of Mitogen-activated protein kinase kinase kinase 3 vs. Ensembl Mouse
Match: Map3k19 (mitogen-activated protein kinase kinase kinase 19 [Source:MGI Symbol;Acc:MGI:1203481])

HSP 1 Score: 147.517 bits (371), Expect = 3.315e-37
Identity = 91/268 (33.96%), Postives = 144/268 (53.73%), Query Frame = 2 
Query: 1457 VGEGGFGKVYQCEDLATNKVMAVKEIKIPKNKKLSDVTS--AIKEILTFSKLECHQRIIQYFDFFQKDEKTFCITMEYMANGSLSSYLEINGPLEEREIARISTQVLEGLLYLHNNQILHRDIKGGNIXXXXXXXXXXXXFGLSKCSEEISGWDFYTG----ILQSNVGTQNWTAPEVLNDEAYGLKADIWSFGATVVEMVVGERPYADYESVQLTFKLLTDKKIEFTPPKTMTRQLEEFIAWCLKPEPHERPTAQLLLNSDFIKLNK 2242
            +G G +G VY C   +  +++AVK++ +  + KL+       ++E +   K   H  I+ Y      +E T  I ME++  GS+SS +   GPL E    + + Q+L+G+ YLH+N ++HRDIKG N++L      KL DFG   C++ ++ W    G    +L+S  GT  W APEV+N+  YG K+DIWS G TV EM  G+ P A  + +   F +   + +    P   +    +F+  CL  + HERP+A  LL   F+K ++
Sbjct:  254 LGRGAYGTVY-CGLTSLGQLIAVKQVALDTSDKLATEKEYRKLQEEVDLLKALKHVNIVAYLGTCL-EENTLSIFMEFVPGGSISSIINRFGPLPEMVFCKYTRQILQGVAYLHDNCVVHRDIKGNNVMLMPTGIIKLIDFG---CAKRLA-WAGLNGTHSDMLKSMRGTPYWMAPEVINESGYGRKSDIWSIGCTVFEMATGKPPLASMDRMAAMFYIGAHRGLMPPLPARFSEPAADFVRLCLTRDQHERPSALQLLKHSFLKRSQ 515
[Close]
BLAST of Mitogen-activated protein kinase kinase kinase 3 vs. Ensembl Mouse
Match: Map3k19 (mitogen-activated protein kinase kinase kinase 19 [Source:MGI Symbol;Acc:MGI:1203481])

HSP 1 Score: 146.362 bits (368), Expect = 1.939e-35
Identity = 91/265 (34.34%), Postives = 142/265 (53.58%), Query Frame = 2 
Query: 1457 VGEGGFGKVYQCEDLATNKVMAVKEIKIPKNKKLSDVTS--AIKEILTFSKLECHQRIIQYFDFFQKDEKTFCITMEYMANGSLSSYLEINGPLEEREIARISTQVLEGLLYLHNNQILHRDIKGGNIXXXXXXXXXXXXFGLSKCSEEISGWDFYTG----ILQSNVGTQNWTAPEVLNDEAYGLKADIWSFGATVVEMVVGERPYADYESVQLTFKLLTDKKIEFTPPKTMTRQLEEFIAWCLKPEPHERPTAQLLLNSDFIK 2233
            +G G +G VY C   +  +++AVK++ +  + KL+       ++E +   K   H  I+ Y      +E T  I ME++  GS+SS +   GPL E    + + Q+L+G+ YLH+N ++HRDIKG N++L      KL DFG   C++ ++ W    G    +L+S  GT  W APEV+N+  YG K+DIWS G TV EM  G+ P A  + +   F +   + +    P   +    +F+  CL  + HERP+A  LL   F+K
Sbjct: 1254 LGRGAYGTVY-CGLTSLGQLIAVKQVALDTSDKLATEKEYRKLQEEVDLLKALKHVNIVAYLGTCL-EENTLSIFMEFVPGGSISSIINRFGPLPEMVFCKYTRQILQGVAYLHDNCVVHRDIKGNNVMLMPTGIIKLIDFG---CAKRLA-WAGLNGTHSDMLKSMRGTPYWMAPEVINESGYGRKSDIWSIGCTVFEMATGKPPLASMDRMAAMFYIGAHRGLMPPLPARFSEPAADFVRLCLTRDQHERPSALQLLKHSFLK 1512
[Close]
BLAST of Mitogen-activated protein kinase kinase kinase 3 vs. Ensembl Mouse
Match: Map3k19 (mitogen-activated protein kinase kinase kinase 19 [Source:MGI Symbol;Acc:MGI:1203481])

HSP 1 Score: 145.591 bits (366), Expect = 3.092e-35
Identity = 91/265 (34.34%), Postives = 142/265 (53.58%), Query Frame = 2 
Query: 1457 VGEGGFGKVYQCEDLATNKVMAVKEIKIPKNKKLSDVTS--AIKEILTFSKLECHQRIIQYFDFFQKDEKTFCITMEYMANGSLSSYLEINGPLEEREIARISTQVLEGLLYLHNNQILHRDIKGGNIXXXXXXXXXXXXFGLSKCSEEISGWDFYTG----ILQSNVGTQNWTAPEVLNDEAYGLKADIWSFGATVVEMVVGERPYADYESVQLTFKLLTDKKIEFTPPKTMTRQLEEFIAWCLKPEPHERPTAQLLLNSDFIK 2233
            +G G +G VY C   +  +++AVK++ +  + KL+       ++E +   K   H  I+ Y      +E T  I ME++  GS+SS +   GPL E    + + Q+L+G+ YLH+N ++HRDIKG N++L      KL DFG   C++ ++ W    G    +L+S  GT  W APEV+N+  YG K+DIWS G TV EM  G+ P A  + +   F +   + +    P   +    +F+  CL  + HERP+A  LL   F+K
Sbjct: 1050 LGRGAYGTVY-CGLTSLGQLIAVKQVALDTSDKLATEKEYRKLQEEVDLLKALKHVNIVAYLGTCL-EENTLSIFMEFVPGGSISSIINRFGPLPEMVFCKYTRQILQGVAYLHDNCVVHRDIKGNNVMLMPTGIIKLIDFG---CAKRLA-WAGLNGTHSDMLKSMRGTPYWMAPEVINESGYGRKSDIWSIGCTVFEMATGKPPLASMDRMAAMFYIGAHRGLMPPLPARFSEPAADFVRLCLTRDQHERPSALQLLKHSFLK 1308
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BLAST of Mitogen-activated protein kinase kinase kinase 3 vs. UniProt/SwissProt
Match: sp|Q99759|M3K3_HUMAN (Mitogen-activated protein kinase kinase kinase 3 OS=Homo sapiens OX=9606 GN=MAP3K3 PE=1 SV=2)

HSP 1 Score: 166.777 bits (421), Expect = 3.474e-42
Identity = 117/303 (38.61%), Postives = 170/303 (56.11%), Query Frame = 2 
Query: 1379 DSYFALRSGISYFSLSKLE-NIVNQDP-----------VGEGGFGKVYQCEDLATNKVMAVKEIKI-PKNKKLSDVTSAIK-EILTFSKLECHQRIIQYFDFFQ-KDEKTFCITMEYMANGSLSSYLEINGPLEEREIARISTQVLEGLLYLHNNQILHRDIKGGNIXXXXXXXXXXXXFGLSKCSEEI--SGWDFYTGILQSNVGTQNWTAPEVLNDEAYGLKADIWSFGATVVEMVVGERPYADYESVQLTFKLLTDKKIEFTPPKTMTRQLEEFIAWCLKPEPHERPTAQLLLNSDFIKL 2236
            D    LRS  S  +LS  E N+  + P           +G+G FG+VY C D+ T + +A K+++  P + + S   SA++ EI     L+ H+RI+QY+   + + EKT  I MEYM  GS+   L+  G L E    + + Q+LEG+ YLH+N I+HRDIKG NIL D   N KL DFG SK  + I  SG    TG ++S  GT  W +PEV++ E YG KAD+WS G TVVEM+  + P+A+YE++   FK+ T +      P  ++    +F+      E  +RP+A+ LL   F +L
Sbjct:  330 DPRGRLRSADSENALSVQERNVPTKSPSAPINWRRGKLLGQGAFGRVYLCYDVDTGRELASKQVQFDPDSPETSKEVSALECEIQLLKNLQ-HERIVQYYGCLRDRAEKTLTIFMEYMPGGSVKDQLKAYGALTESVTRKYTRQILEGMSYLHSNMIVHRDIKGANILRDSAGNVKLGDFGASKRLQTICMSG----TG-MRSVTGTPYWMSPEVISGEGYGRKADVWSLGCTVVEMLTEKPPWAEYEAMAAIFKIAT-QPTNPQLPSHISEHGRDFLRRIFV-EARQRPSAEELLTHHFAQL 624
[Close]
BLAST of Mitogen-activated protein kinase kinase kinase 3 vs. UniProt/SwissProt
Match: sp|Q61084|M3K3_MOUSE (Mitogen-activated protein kinase kinase kinase 3 OS=Mus musculus OX=10090 GN=Map3k3 PE=1 SV=1)

HSP 1 Score: 165.236 bits (417), Expect = 1.116e-41
Identity = 107/265 (40.38%), Postives = 156/265 (58.87%), Query Frame = 2 
Query: 1457 VGEGGFGKVYQCEDLATNKVMAVKEIKI-PKNKKLSDVTSAIK-EILTFSKLECHQRIIQYFDFFQ-KDEKTFCITMEYMANGSLSSYLEINGPLEEREIARISTQVLEGLLYLHNNQILHRDIKGGNIXXXXXXXXXXXXFGLSKCSEEI--SGWDFYTGILQSNVGTQNWTAPEVLNDEAYGLKADIWSFGATVVEMVVGERPYADYESVQLTFKLLTDKKIEFTPPKTMTRQLEEFIAWCLKPEPHERPTAQLLLNSDFIKL 2236
            +G+G FG+VY C D+ T + +A K+++  P + + S   SA++ EI     L+ H+RI+QY+   + + EK   I MEYM  GS+   L+  G L E    + + Q+LEG+ YLH+N I+HRDIKG NIL D   N KL DFG SK  + I  SG    TGI +S  GT  W +PEV++ E YG KAD+WS G TVVEM+  + P+A+YE++   FK+ T +      P  ++    +F+      E  +RP+A+ LL   F +L
Sbjct:  368 LGQGAFGRVYLCYDVDTGRELASKQVQFDPDSPETSKEVSALECEIQLLKNLQ-HERIVQYYGCLRDRAEKILTIFMEYMPGGSVKDQLKAYGALTESVTRKYTRQILEGMSYLHSNMIVHRDIKGANILRDSAGNVKLGDFGASKRLQTICMSG----TGI-RSVTGTPYWMSPEVISGEGYGRKADVWSLGCTVVEMLTEKPPWAEYEAMAAIFKIAT-QPTNPQLPSHISEHGRDFLRRIFV-EARQRPSAEELLTHHFAQL 624
[Close]
BLAST of Mitogen-activated protein kinase kinase kinase 3 vs. UniProt/SwissProt
Match: sp|Q9Y2U5|M3K2_HUMAN (Mitogen-activated protein kinase kinase kinase 2 OS=Homo sapiens OX=9606 GN=MAP3K2 PE=1 SV=2)

HSP 1 Score: 159.844 bits (403), Expect = 7.060e-40
Identity = 104/262 (39.69%), Postives = 151/262 (57.63%), Query Frame = 2 
Query: 1457 VGEGGFGKVYQCEDLATNKVMAVKEIKI-PKNKKLSDVTSAIKEILTFSKLECHQRIIQYFDFFQ-KDEKTFCITMEYMANGSLSSYLEINGPLEEREIARISTQVLEGLLYLHNNQILHRDIKGGNIXXXXXXXXXXXXFGLSKCSEEI--SGWDFYTGILQSNVGTQNWTAPEVLNDEAYGLKADIWSFGATVVEMVVGERPYADYESVQLTFKLLTDKKIEFTPPKTMTRQLEEFIAWCLKPEPHERPTAQLLLNSDFI 2230
            +G+G FG+VY C D+ T + +AVK+++  P + + S   +A++  +   K   H+RI+QY+   +   EKT  I MEYM  GS+   L+  G L E    + + Q+LEG+ YLH+N I+HRDIKG NIL D   N KL DFG SK  + I  SG    TG ++S  GT  W +PEV++ E YG KADIWS   TVVEM+  + P+A++E++   FK+ T       PP  ++    +F+      E   RP+A  LL   F+
Sbjct:  362 LGQGAFGRVYLCYDVDTGRELAVKQVQFDPDSPETSKEVNALECEIQLLKNLLHERIVQYYGCLRDPQEKTLSIFMEYMPGGSIKDQLKAYGALTENVTRKYTRQILEGVHYLHSNMIVHRDIKGANILRDSTGNVKLGDFGASKRLQTICLSG----TG-MKSVTGTPYWMSPEVISGEGYGRKADIWSVACTVVEMLTEKPPWAEFEAMAAIFKIATQPTNPKLPPH-VSDYTRDFLKRIFV-EAKLRPSADELLRHMFV 616
[Close]
BLAST of Mitogen-activated protein kinase kinase kinase 3 vs. UniProt/SwissProt
Match: sp|Q01389|BCK1_YEAST (Serine/threonine-protein kinase BCK1/SLK1/SSP31 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) OX=559292 GN=BCK1 PE=1 SV=1)

HSP 1 Score: 158.688 bits (400), Expect = 1.670e-38
Identity = 99/270 (36.67%), Postives = 155/270 (57.41%), Query Frame = 2 
Query: 1457 VGEGGFGKVYQCEDLATNKVMAVKEIKIPKNKK-----LSDVTSAIKEILTFSKLECHQRIIQYFDFFQKDEKTFCITMEYMANGSLSSYLEINGPLEEREIARISTQVLEGLLYLHNNQILHRDIKGGNIXXXXXXXXXXXXFGLSKCSEEISGWDFYTGILQSNVGTQNWTAPEVLN-DEAYGLKADIWSFGATVVEMVVGERPYADYESVQLTFKLLTDKKIEFTPPKTM---TRQLEEFIAWCLKPEPHERPTAQLLLNSDFIKLN 2239
            +G+G FG VY C ++ T ++MAVK++++PK        LS V +   E+ T   L+ H  I+QY  F  K+   + + +EY+A GS+ S + + G  +E  I  ++TQVL+GL YLH+  ILHRD+K  N+LLD     K++DFG+S+ S++I     Y+    +  GT  W APE+++  + Y  K DIWS G  V+EM  G+RP+++ E V   FK+   K     P  T+   ++    F+  C +  P +RPTA  LL+  F ++N
Sbjct: 1181 IGKGSFGAVYLCLNVTTGEMMAVKQVEVPKYSSQNEAILSTVEALRSEVSTLKDLD-HLNIVQYLGFENKNN-IYSLFLEYVAGGSVGSLIRMYGRFDEPLIKHLTTQVLKGLAYLHSKGILHRDMKADNLLLDQDGICKISDFGISRKSKDI-----YSNSDMTMRGTVFWMAPEMVDTKQGYSAKVDIWSLGCIVLEMFAGKRPWSNLEVVAAMFKIGKSKSAPPIPEDTLPLISQIGRNFLDACFEINPEKRPTANELLSHPFSEVN 1443
[Close]
BLAST of Mitogen-activated protein kinase kinase kinase 3 vs. UniProt/SwissProt
Match: sp|Q86IX1|DST1_DICDI (Serine/threonine-protein kinase dst1 OS=Dictyostelium discoideum OX=44689 GN=dst1 PE=3 SV=1)

HSP 1 Score: 156.762 bits (395), Expect = 1.841e-38
Identity = 102/268 (38.06%), Postives = 153/268 (57.09%), Query Frame = 2 
Query: 1448 QDPVGEGGFGKVYQCEDLATNKVMAVKEIKIPKNKKLSDVTSAIKEILTFSKLEC-HQRIIQYFDFFQKDEKTFCITMEYMANGSLSSYLEINGPLEEREIARISTQVLEGLLYLHNNQILHRDIKGGNIXXXXXXXXXXXXFGLSKCSEEISGWDFYTGILQSN--VGTQNWTAPEVLNDEAYGLKADIWSFGATVVEMVVGERPYADYESVQLTFKLLTDKKIEFTPPKTMTRQLEEFIAWCLKPEPHERPTAQLLLNSDFIKLNK 2242
            Q+ +G+G FG+V++    A  KV+A+K I +   + + DV    KEI   +  EC +  I+QYF  + KD + + I MEY   GS+S  L++   + E EIA I  + L+GL YLH  + +HRDIKGGNILL+D+   KLADFG+S           +    + N  VGT  W APEV+ +  Y  KAD+WS G T +EM  G  P ++   +++ F +  ++    T     + + ++FI+ CL  +P ERPTA+ LLN +FI+  K
Sbjct:   32 QERLGKGSFGQVFKAVHFANGKVVAIKIISLDDQEAIKDVR---KEISILA--ECNYPNIVQYFGSYFKDHQLW-IVMEYCGGGSVSDLLQVIDTISEDEIALICREALKGLNYLHEFKKIHRDIKGGNILLNDRGEVKLADFGVSA--------QLFNTFSKRNTFVGTPYWMAPEVIQENKYDGKADVWSLGITAIEMAEGLPPNSNVHPMRVIFMIPREESPALTDKSIWSDKFQDFISKCLTKDPAERPTAKELLNHEFIQTKK 285
[Close]
BLAST of Mitogen-activated protein kinase kinase kinase 3 vs. TrEMBL
Match: A0A2T7Q0V7 (Uncharacterized protein OS=Pomacea canaliculata OX=400727 GN=C0Q70_01932 PE=4 SV=1)

HSP 1 Score: 183.726 bits (465), Expect = 1.553e-45
Identity = 104/260 (40.00%), Postives = 156/260 (60.00%), Query Frame = 2 
Query: 1457 VGEGGFGKVYQCEDLATNKVMAVKEIKIPK-NKKLSDVTSAIKEILTFSKLECHQRIIQYFDFFQKDEKTFCITMEYMANGSLSSYLEINGPLEEREIARISTQVLEGLLYLHNNQILHRDIKGGNIXXXXXXXXXXXXFGLSKCSEEISGWDFYTGILQSNVGTQNWTAPEVLNDEAYGLKADIWSFGATVVEMVVGERPYADYESVQLTFKLLTDKKIEFTPPKTMTRQLEEFIAWCLKPEPHERPTAQLLLNSDFIK 2233
            +G G FG VYQC D  T   +AVK++++   N ++S    A++  +   +   H+RI+QY+   Q+D     I +E+M  GS+  +L+ +GPL E    + S QVLEGL +LH N I+HRDIK  N+L D   N KL DFG SK  + I+     TG L++ VGT +W APEV+N E YG KAD+WS G T+VEM+  + P+ADYE +   F++ T K  ++  P T +  + +F+    +  P +RP+A+ LL   F++
Sbjct:  376 LGTGAFGMVYQCYDQDTGMELAVKQVQLGAMNAEVSKEVRALENEVQLLRNFQHERIVQYYGC-QQDASVLSIFIEFMPGGSVQDHLKQHGPLNEVLARKYSRQVLEGLAFLHKNVIVHRDIKAANVLRDTMGNVKLGDFGASKRLQVIASA---TG-LKTAVGTPHWMAPEVINGEGYGRKADVWSVGCTLVEMLTSKPPFADYEPLAAMFQIATSKHPKYELPATCSTSVRDFLMLTFQRTPTDRPSAEDLLKDKFVR 630
[Close]
BLAST of Mitogen-activated protein kinase kinase kinase 3 vs. TrEMBL
Match: A7S4G7 (Predicted protein (Fragment) OS=Nematostella vectensis OX=45351 GN=v1g104385 PE=4 SV=1)

HSP 1 Score: 169.088 bits (427), Expect = 1.414e-43
Identity = 106/259 (40.93%), Postives = 151/259 (58.30%), Query Frame = 2 
Query: 1457 VGEGGFGKVYQCEDLATNKVMAVKEIKIPK-NKKLSDVTSAIKEILTFSKLECHQRIIQYFDFFQKDEKTFCITMEYMANGSLSSYLEINGPLEEREIARISTQVLEGLLYLHNNQILHRDIKGGNIXXXXXXXXXXXXFGLSKCSEEISGWDFYTGILQSNVGTQNWTAPEVLNDEAYGLKADIWSFGATVVEMVVGERPYADYESVQLTFKLLTDKKIEFTPPKTMTRQLEEFIAWCLKPEPHERPTAQLLLNSDFI 2230
            +G G FG+VY C DL T + +AVK+I+  + N    +   A++  + F K   ++RI+QY+   + D+    I MEY+  GS+  +++ +G L E    + S Q+LEG+LYLH N+I+HRDIKG NIL D   N KLADFG SK  + I      TG  +S  GT  W APEV+N E YG KAD+WS G TVVEM+  + P+AD+E +   FK+ T +  E   P  ++    EF+   L+     RP+A  LL   F+
Sbjct:   10 LGAGAFGQVYMCHDLDTGRELAVKQIETGQLNSSTKNEVKALEGEIEFMKAFRNERIVQYYGI-ETDDLHIYIFMEYLPGGSIHEHIKQHGALNESLTRKYSRQILEGILYLHTNRIVHRDIKGANILRDLYGNVKLADFGASKRLQTIRS---KTG-FRSVHGTPYWMAPEVINGEGYGRKADVWSVGCTVVEMLTTKPPWADFEPMAALFKIAT-QPTEPELPSDLSVDAVEFVRSTLRMNSKSRPSADELLRFSFV 262
[Close]
BLAST of Mitogen-activated protein kinase kinase kinase 3 vs. TrEMBL
Match: F6XXK9 (Sterile alpha motif domain containing 8 OS=Xenopus tropicalis OX=8364 GN=ilkap PE=4 SV=1)

HSP 1 Score: 177.178 bits (448), Expect = 2.297e-43
Identity = 112/264 (42.42%), Postives = 156/264 (59.09%), Query Frame = 2 
Query: 1457 VGEGGFGKVYQCEDLATNKVMAVKEIKI-PKNKKLSDVTSAIKEILTFSKLECHQRIIQYFDFFQ-KDEKTFCITMEYMANGSLSSYLEINGPLEEREIARISTQVLEGLLYLHNNQILHRDIKGGNIXXXXXXXXXXXXFGLSKCSEEI--SGWDFYTGILQSNVGTQNWTAPEVLNDEAYGLKADIWSFGATVVEMVVGERPYADYESVQLTFKLLTDKKIEFTPPKTMTRQLEEFIAWCLKPEPHERPTAQLLLNSDFIKL 2236
            +G+G FG+VY C D+ T + +A K+++  P + + S   SA++  +   K   H RI+QY+   + K EKT  I MEYM  GS+   L+  G L E    R + Q+LEG+ YLH+N I+HRDIKG NIL D   N KL DFG SK  + I  SG    TGI +S  GT  W +PEV++ E YG KAD+WS G TVVEM+  + P+A+YE++   FK+ T       PP T + Q  +F+   L  E  +RPTA+ L+   F +L
Sbjct:  353 LGQGAFGRVYLCYDVDTGRELAAKQVQFDPDSPETSKEVSALECEIQLLKNLHHDRIVQYYGSLRDKGEKTLTIFMEYMPGGSVKDQLKAYGALTENVTRRYTRQILEGVSYLHSNMIVHRDIKGANILRDSAGNVKLGDFGASKRLQTICMSG----TGI-RSVTGTPYWMSPEVISGEGYGRKADVWSLGCTVVEMLTEKPPWAEYEAMAAIFKIATQPTNPQLPPNT-SEQCRDFVKRILV-EARQRPTAEELIRHPFAQL 609
[Close]
BLAST of Mitogen-activated protein kinase kinase kinase 3 vs. TrEMBL
Match: A0A2G9SHV3 (Mitogen-activated protein kinase kinase kinase 3 OS=Lithobates catesbeianus OX=8400 GN=AB205_0069650 PE=4 SV=1)

HSP 1 Score: 176.792 bits (447), Expect = 2.769e-43
Identity = 121/297 (40.74%), Postives = 167/297 (56.23%), Query Frame = 2 
Query: 1394 LRSGISYFSLSKLE-NIVNQDP-----------VGEGGFGKVYQCEDLATNKVMAVKEIKI-PKNKKLSDVTSAIKEILTFSKLECHQRIIQYFDFFQ-KDEKTFCITMEYMANGSLSSYLEINGPLEEREIARISTQVLEGLLYLHNNQILHRDIKGGNIXXXXXXXXXXXXFGLSKCSEEI--SGWDFYTGILQSNVGTQNWTAPEVLNDEAYGLKADIWSFGATVVEMVVGERPYADYESVQLTFKLLTDKKIEFTPPKTMTRQLEEFIAWCLKPEPHERPTAQLLLNSDFIKL 2236
            LRS  S  +LS  E NI  + P           +G+G FG+VY C D+   + +A K+++  P + + S   SA++  +   K   H RI+QY+   + K EKT  I MEYM  GS+   L+  G L E    R + Q+LEG+ YLH+N I+HRDIKG NIL D   N KL DFG SK  + I  SG    TGI +S  GT  W +PEV++ E YG KAD+WS G TVVEM+  + P+A+YE++   FK+ T       PP T + Q  +F+   L  E  +RP+A+ LL   F +L
Sbjct:  326 LRSADSENTLSVPERNIAKKSPSAPINWRRGKLLGQGAFGRVYLCYDVDIGRELAAKQVQFDPDSPETSKEVSALECEIQLLKNLHHDRIVQYYGCLRDKGEKTLTIFMEYMPGGSVKDQLKAYGALTENVTRRYTRQILEGVSYLHSNMIVHRDIKGANILRDSAGNVKLGDFGASKRLQTICMSG----TGI-RSVTGTPYWMSPEVISGEGYGRKADVWSLGCTVVEMLTEKPPWAEYEAMAAIFKIATQPTNPQLPPNT-SEQCRDFVKRILV-EARQRPSAEELLRHSFAQL 615
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BLAST of Mitogen-activated protein kinase kinase kinase 3 vs. TrEMBL
Match: A0A0S7KX40 (M3K2 (Fragment) OS=Poeciliopsis prolifica OX=188132 GN=M3K2 PE=4 SV=1)

HSP 1 Score: 167.933 bits (424), Expect = 3.173e-43
Identity = 107/262 (40.84%), Postives = 150/262 (57.25%), Query Frame = 2 
Query: 1457 VGEGGFGKVYQCEDLATNKVMAVKEIKI-PKNKKLSDVTSAIKEILTFSKLECHQRIIQYFDFFQKD-EKTFCITMEYMANGSLSSYLEINGPLEEREIARISTQVLEGLLYLHNNQILHRDIKGGNIXXXXXXXXXXXXFGLSKCSEEI--SGWDFYTGILQSNVGTQNWTAPEVLNDEAYGLKADIWSFGATVVEMVVGERPYADYESVQLTFKLLTDKKIEFTPPKTMTRQLEEFIAWCLKPEPHERPTAQLLLNSDFI 2230
            +G+G FG+VY C D  T + +AVK+++  P + + S   SA++  +   K  CH RI+QY+   +   E+T  I ME+M  GS+   L+  G L E    R + Q+LEG+ YLH+N I+HRDIKG NIL D   N KL DFG S+  + I  SG    TGI +S  GT  W +PEV++ E YG KADIWS G TVVEM+    P+A++E++   FK+ T       PP  ++    EF+        H RP+A  LL   F+
Sbjct:   20 LGQGAFGRVYLCYDADTGRELAVKQVQFDPDSPETSKEVSALECEIQLLKNLCHDRIVQYYGCLRDSLERTLSIFMEHMPGGSIKDQLKAYGALTENVTRRYTRQILEGVSYLHSNMIVHRDIKGANILRDSVGNVKLGDFGASRRLQTICLSG----TGI-KSVTGTPYWMSPEVISGEGYGRKADIWSVGCTVVEMLTQRPPWAEFEAMAAIFKIATQPTNPVLPPH-VSDHCREFLRRIFVETKH-RPSADELLRHFFV 274
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BLAST of Mitogen-activated protein kinase kinase kinase 3 vs. Ensembl Cavefish
Match: map3k3 (mitogen-activated protein kinase kinase kinase 3 [Source:NCBI gene;Acc:103034596])

HSP 1 Score: 166.007 bits (419), Expect = 5.348e-43
Identity = 103/262 (39.31%), Postives = 151/262 (57.63%), Query Frame = 2 
Query: 1457 VGEGGFGKVYQCEDLATNKVMAVKEIKI-PKNKKLSDVTSAIKEILTFSKLECHQRIIQYFDFFQ-KDEKTFCITMEYMANGSLSSYLEINGPLEEREIARISTQVLEGLLYLHNNQILHRDIKGGNIXXXXXXXXXXXXFGLSKCSEEISGWDFYTGILQSNVGTQNWTAPEVLNDEAYGLKADIWSFGATVVEMVVGERPYADYESVQLTFKLLTDKKIEFTPPKTMTRQLEEFIAWCLKPEPHERPTAQLLLNSDFIKL 2236
            +G+G FG+VY C D+ T + +A K+++  P + + S   S ++  +   K   H+RI+QY+   +  +EKT  I MEYM  GS+   L+  G L E    + + Q+LEG+ YLH+N I+HRDIKG NIL D   N KL DFG SK  + I      TG+ +S  GT  W +PEV++ + YG KAD+WS G TVVEM+  + P+A+YE++   FK+ T       P  T + Q  +FI        H RP+A+ LL   F ++
Sbjct:  362 LGQGAFGRVYLCYDVDTGRELAAKQVQFDPASPETSKEVSTLECEIQLLKNLHHERIVQYYGCLRDHNEKTLTIFMEYMPGGSVKDQLKAYGALTENVTRKYTRQILEGMSYLHSNMIVHRDIKGANILRDSAGNVKLGDFGASKRLQTICMSS--TGV-RSVTGTPYWMSPEVISGDGYGRKADVWSLGCTVVEMLTEKPPWAEYEAMAAIFKIATQPTNPILPSHT-SEQTRDFIRRIFVEAKH-RPSAEELLRHPFSQI 618
[Close]
BLAST of Mitogen-activated protein kinase kinase kinase 3 vs. Ensembl Cavefish
Match: map3k3 (mitogen-activated protein kinase kinase kinase 3 [Source:NCBI gene;Acc:103034596])

HSP 1 Score: 166.007 bits (419), Expect = 5.348e-43
Identity = 103/262 (39.31%), Postives = 151/262 (57.63%), Query Frame = 2 
Query: 1457 VGEGGFGKVYQCEDLATNKVMAVKEIKI-PKNKKLSDVTSAIKEILTFSKLECHQRIIQYFDFFQ-KDEKTFCITMEYMANGSLSSYLEINGPLEEREIARISTQVLEGLLYLHNNQILHRDIKGGNIXXXXXXXXXXXXFGLSKCSEEISGWDFYTGILQSNVGTQNWTAPEVLNDEAYGLKADIWSFGATVVEMVVGERPYADYESVQLTFKLLTDKKIEFTPPKTMTRQLEEFIAWCLKPEPHERPTAQLLLNSDFIKL 2236
            +G+G FG+VY C D+ T + +A K+++  P + + S   S ++  +   K   H+RI+QY+   +  +EKT  I MEYM  GS+   L+  G L E    + + Q+LEG+ YLH+N I+HRDIKG NIL D   N KL DFG SK  + I      TG+ +S  GT  W +PEV++ + YG KAD+WS G TVVEM+  + P+A+YE++   FK+ T       P  T + Q  +FI        H RP+A+ LL   F ++
Sbjct:  362 LGQGAFGRVYLCYDVDTGRELAAKQVQFDPASPETSKEVSTLECEIQLLKNLHHERIVQYYGCLRDHNEKTLTIFMEYMPGGSVKDQLKAYGALTENVTRKYTRQILEGMSYLHSNMIVHRDIKGANILRDSAGNVKLGDFGASKRLQTICMSS--TGV-RSVTGTPYWMSPEVISGDGYGRKADVWSLGCTVVEMLTEKPPWAEYEAMAAIFKIATQPTNPILPSHT-SEQTRDFIRRIFVEAKH-RPSAEELLRHPFSQI 618
[Close]
BLAST of Mitogen-activated protein kinase kinase kinase 3 vs. Ensembl Cavefish
Match: map3k3 (mitogen-activated protein kinase kinase kinase 3 [Source:NCBI gene;Acc:103034596])

HSP 1 Score: 166.007 bits (419), Expect = 5.348e-43
Identity = 103/262 (39.31%), Postives = 151/262 (57.63%), Query Frame = 2 
Query: 1457 VGEGGFGKVYQCEDLATNKVMAVKEIKI-PKNKKLSDVTSAIKEILTFSKLECHQRIIQYFDFFQ-KDEKTFCITMEYMANGSLSSYLEINGPLEEREIARISTQVLEGLLYLHNNQILHRDIKGGNIXXXXXXXXXXXXFGLSKCSEEISGWDFYTGILQSNVGTQNWTAPEVLNDEAYGLKADIWSFGATVVEMVVGERPYADYESVQLTFKLLTDKKIEFTPPKTMTRQLEEFIAWCLKPEPHERPTAQLLLNSDFIKL 2236
            +G+G FG+VY C D+ T + +A K+++  P + + S   S ++  +   K   H+RI+QY+   +  +EKT  I MEYM  GS+   L+  G L E    + + Q+LEG+ YLH+N I+HRDIKG NIL D   N KL DFG SK  + I      TG+ +S  GT  W +PEV++ + YG KAD+WS G TVVEM+  + P+A+YE++   FK+ T       P  T + Q  +FI        H RP+A+ LL   F ++
Sbjct:  362 LGQGAFGRVYLCYDVDTGRELAAKQVQFDPASPETSKEVSTLECEIQLLKNLHHERIVQYYGCLRDHNEKTLTIFMEYMPGGSVKDQLKAYGALTENVTRKYTRQILEGMSYLHSNMIVHRDIKGANILRDSAGNVKLGDFGASKRLQTICMSS--TGV-RSVTGTPYWMSPEVISGDGYGRKADVWSLGCTVVEMLTEKPPWAEYEAMAAIFKIATQPTNPILPSHT-SEQTRDFIRRIFVEAKH-RPSAEELLRHPFSQI 618
[Close]
BLAST of Mitogen-activated protein kinase kinase kinase 3 vs. Ensembl Cavefish
Match: map3k2 (mitogen-activated protein kinase kinase kinase 2 [Source:NCBI gene;Acc:103026704])

HSP 1 Score: 159.844 bits (403), Expect = 7.097e-41
Identity = 103/262 (39.31%), Postives = 151/262 (57.63%), Query Frame = 2 
Query: 1457 VGEGGFGKVYQCEDLATNKVMAVKEIKI-PKNKKLSDVTSAIKEILTFSKLECHQRIIQYFDFFQK-DEKTFCITMEYMANGSLSSYLEINGPLEEREIARISTQVLEGLLYLHNNQILHRDIKGGNIXXXXXXXXXXXXFGLSKCSEEI--SGWDFYTGILQSNVGTQNWTAPEVLNDEAYGLKADIWSFGATVVEMVVGERPYADYESVQLTFKLLTDKKIEFTPPKTMTRQLEEFIAWCLKPEPHERPTAQLLLNSDFI 2230
            +G+G FG+V+ C D  T + +AVK+++  P + + S   SA++  +   K   H+RI+QY+   +   E+T  I MEYM  GS+   L+  G L E    + + Q+LEG+ YLH+N I+HRDIKG NIL D   N KL DFG S+  + I  SG    TGI +S  GT  W +PEV++ E YG KADIWS G TVVEM+    P+A++E++   FK+ T +      P  ++    +F+      E  +RP A+ LL   F+
Sbjct:  365 LGQGAFGRVFLCYDADTGRELAVKQVQFDPDSPETSKEVSALECEIQLLKNLFHERIVQYYGCLRDTHERTLSIFMEYMPGGSIKDQLKSYGALTENVTRKYTRQILEGVCYLHSNMIVHRDIKGANILRDSAGNVKLGDFGASRRLQTICLSG----TGI-KSVTGTPYWMSPEVISGEGYGRKADIWSVGCTVVEMLTLRPPWAEFEAMAAIFKIAT-QPTNPALPAHVSDHCRDFLKRIFV-ETKQRPAAEELLRHIFV 619
[Close]
BLAST of Mitogen-activated protein kinase kinase kinase 3 vs. Ensembl Cavefish
Match: map3k22 (mitogen-activated protein kinase kinase kinase 3-like [Source:NCBI gene;Acc:103044968])

HSP 1 Score: 155.221 bits (391), Expect = 2.607e-39
Identity = 101/263 (38.40%), Postives = 153/263 (58.17%), Query Frame = 2 
Query: 1457 VGEGGFGKVYQCEDLATNKVMAVKEIKI-PKNKKLSDVTSAIKEILTFSKLECHQRIIQYFDFFQKDE-KTFCITMEYMANGSLSSYLEINGPLEEREIARISTQVLEGLLYLHNNQILHRDIKGGNIXXXXXXXXXXXXFGLSKCSEEI--SGWDFYTGILQSNVGTQNWTAPEVLNDEAYGLKADIWSFGATVVEMVVGERPYADYESVQLTFKLLTDKKIEFTPPKTMTRQLEEFIAWCLKPEPHERPTAQLLLNSDFIK 2233
            +G G FG+VY C D  T + +AVK++   P+  + S   +A++  +   K   H+RI+QY+   +  E +   I +E+M  GS+   L+  G L E+   R + Q+L+G+ YLH+N I+HRDIKG NIL D   N KL DFG SK  + I  SG    TGI ++  GT  W +PEV+N E YG KAD+WS   TVVEM+  + P+A+YE++   FK+ T +  +   P+ ++    +F+      E   RPTA+ LL+  F++
Sbjct:  363 LGRGAFGEVYLCYDADTGRELAVKQVPFDPECHETSKEVNALECEIQLLKNLRHERIVQYYGCLRDPEQRKLSIFVEFMPGGSIKDQLKAYGALTEKVTRRYTRQILQGVFYLHSNMIVHRDIKGANILRDSSGNVKLGDFGASKRIQTICMSG----TGI-KTVTGTPYWMSPEVINGEGYGRKADVWSVACTVVEMLTQKPPWAEYEAMAAIFKIAT-QPTKPNLPEGVSDACRDFLRQVFV-EEKWRPTAEGLLSHPFVQ 618
[Close]
BLAST of Mitogen-activated protein kinase kinase kinase 3 vs. Ensembl Sea Lamprey
Match: map3k2 (mitogen-activated protein kinase kinase kinase 2 [Source:ZFIN;Acc:ZDB-GENE-120215-96])

HSP 1 Score: 158.303 bits (399), Expect = 5.378e-41
Identity = 103/272 (37.87%), Postives = 150/272 (55.15%), Query Frame = 2 
Query: 1457 VGEGGFGKVYQCEDLATNKVMAVKEIKI-PKNKKLSDVTSAIK-EILTFSKLECHQRIIQYFDFFQ-KDEKTFCITMEYMANGSLSSYLEINGPLEEREIARISTQVLEGLLYLHNNQILHRDIKGGNIXXXXXXXXXXXXFGLSK-----CSEEISGWDFYTGILQSNVGTQNWTAPEVLNDEAYGLKADIWSFGATVVEMVVGERPYADYESVQLTFKLL---TDKKIEFTPPKTMTRQLEEFIAWCLKPEPHERPTAQLLLNSDFIKLN 2239
            +G+G FG+VY C D  T + +AVK+++  P + + S   +A++ EI     L+ H+RI+QYF   +   +KT  I MEYM  GS+   L   G L E    + + Q+LEG+ +LH N I+HRDIKG NIL D   N KL DFG SK     CS+  +        ++S  GT  W +PEV+N E YG KADIWS G TVVEM+  + P+A++E++   FK+    TD ++     +     L          E   RP+A+ LL   F+ ++
Sbjct:  365 LGQGAFGRVYLCYDADTGRELAVKQVQFDPGSVETSKEVNALECEIQLLKNLQ-HERIVQYFGCLRDPQQKTLSIFMEYMPGGSIKDQLRAYGALTENVTRKYTRQILEGVSFLHGNMIVHRDIKGANILRDSTGNVKLGDFGASKRLQTICSQGTA--------MRSVTGTPYWMSPEVINGEGYGRKADIWSVGCTVVEMLTEKPPWAEFEAMAAIFKIATQPTDPRLPLHASEHARDLLRRIFV-----EAKLRPSAEDLLRHPFVHVH 622
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BLAST of Mitogen-activated protein kinase kinase kinase 3 vs. Ensembl Sea Lamprey
Match: stk25a (serine/threonine kinase 25a [Source:ZFIN;Acc:ZDB-GENE-041010-92])

HSP 1 Score: 129.798 bits (325), Expect = 1.798e-32
Identity = 97/270 (35.93%), Postives = 149/270 (55.19%), Query Frame = 2 
Query: 1433 ENIVNQDPVGEGGFGKVYQCEDLATNKVMAVKEIKIPKNKKLSDVTSAIKEILTFSKLECHQRIIQYFDFFQKDEKTFCITMEYMANGSLSSYLEINGPLEEREIARISTQVLEGLLYLHNNQILHRDIKG--GNIXXXXXXXXXXXXFGLSKCSEEISGWDFYTGILQSN-VGTQNWTAPEVLNDEAYGLKADIWSFGATVVEMVVGERPYADYESVQLTFKLLTDKKIEFTPPKTMTRQLEEFIAWCLKPEPHERPTAQLLLNSDFIK 2233
            E    Q+ +G+G FG+V++  D  T +V+A+K I + + +   +     +EI   S+ +    +  YF  + K  K + I MEY+  GS    ++  GPLEE +IA I  ++L+GL YLH+ + +HRDIKG   N+LL ++ + KLADFG       ++G    T I ++  VGT  W APEV+   AY  KADIWS G T +E+  GE P ++   +++ F  L  K    T     ++  +EF+  CL  +P  RPTA+ LL   FI+
Sbjct:   24 ELFTKQERIGKGSFGEVFKGIDNRTKEVVAIKIIDLEEAEDEIEDIQ--QEITVLSQCDS-PYVTHYFGSYLKGTKLWII-MEYLGGGSALDLIK-PGPLEEHQIATILREILKGLDYLHSERKIHRDIKGPAANVLLSEQGDVKLADFG-------VAGQLTDTQIKRNTFVGTPFWMAPEVIKQSAYDFKADIWSLGITAIELAKGEPPNSELHPMRVLF--LIPKNNPPTLEGNYSKAFKEFVDSCLNKDPQFRPTAKELLKHKFIQ 279
[Close]
BLAST of Mitogen-activated protein kinase kinase kinase 3 vs. Ensembl Sea Lamprey
Match: MAP4K3 (mitogen-activated protein kinase kinase kinase kinase 3 [Source:HGNC Symbol;Acc:HGNC:6865])

HSP 1 Score: 127.872 bits (320), Expect = 1.381e-30
Identity = 90/268 (33.58%), Postives = 142/268 (52.99%), Query Frame = 2 
Query: 1457 VGEGGFGKVYQCEDLATNKVMAVKEIKIPKNKKLSDVTSAIKEILTFSKLEC-HQRIIQYFDFFQKDEKTFCITMEYMANGSLSSYLEINGPLEEREIARISTQVLEGLLYLHNNQILHRDIKGGNIXXXXXXXXXXXXFGLSKCSEEISGWDFYTGILQSNVGTQNWTAPEVLNDE---AYGLKADIWSFGATVVEMVVGERPYADYESVQLTFKLLTDKKIEFTPPKTMTRQ-----LEEFIAWCLKPEPHERPTAQLLLNSDFIK 2233
            +G G +G V++  ++ T +++A+K IK+    +  D  S I++ +   K EC H  I+ Y+  + + +K + I ME+   GSL     + GPL ER+IA ++ + L+GL YLH+   +HRDIKG NILL D  + KLADFG+S    +I+         +S +GT  W APEV   E    Y  + D+W+ G T +E+   + P  D   ++  F +    K  F PPK   +Q        FI   L   P +RPTA+ +L   +++
Sbjct:   20 LGSGTYGDVHKARNVQTGELVAIKIIKL----EPGDDFSVIQQEIVMMK-ECKHTNIVAYYGSYLRHDKLW-ICMEHCGGGSLQDIYHVTGPLTERQIAYVTRETLQGLAYLHSEGKMHRDIKGANILLTDDGDVKLADFGVSA---QITA---TIAKRKSFIGTPYWMAPEVAAVERKGGYNHQCDVWAVGITAIELAELQPPMFDLHPMRALFLM---SKSGFQPPKLRDKQKWSPVFHNFIKMALTKNPKKRPTAEKMLTHSYVQ 272
[Close]
BLAST of Mitogen-activated protein kinase kinase kinase 3 vs. Ensembl Sea Lamprey
Match: map3k19 (mitogen-activated protein kinase kinase kinase 19 [Source:ZFIN;Acc:ZDB-GENE-081104-140])

HSP 1 Score: 117.472 bits (293), Expect = 1.778e-29
Identity = 80/279 (28.67%), Postives = 133/279 (47.67%), Query Frame = 2 
Query: 1442 VNQDPVGEGGFGKVYQCEDLATNKVMAVKEIKI---------PKNKKLSDVTSAIKEILTFSKLECHQRIIQYFDFFQKDEKTFCITMEYMANGSLSSYLEINGPLEEREIARISTQVLEGLLYLHNNQILHRDIKGGNIXXXXXXXXXXXXFGLSK-------CSEEISGWDFYTGILQSNVGTQNWTAPEVLNDEAYGLKADIWSFGATVVEMVVGERPYADYESVQLTFKLLTDKKIEFTPPKTMTRQLEEFIAWCLKPEPHERPTAQLLLNSDFI 2230
            +  + +G+G FG V+        K++AVKE+++            +K S++     E+   + L  H  +++Y    + +   F I ME++  G+++  +   GPL E        Q+  GL YLH + ++H D+KG N ++      KL DFG ++       C E         G L S  GT  W APEV+N   Y  +AD+WS G T+ EM VG  P+AD   +     +     I    P+  +++ +EF+  C   +  +RP++Q LL+  FI
Sbjct:   16 IKGNRLGKGAFGTVF-LGLTNQGKLIAVKELELRDAQSANGNQGGQKQSELQKLQDEVELLTTLH-HPNVVEYLGT-EMEGNRFSIFMEFVPGGTVAETVRGFGPLGESVCRSYIAQMTRGLAYLHGHGVMHGDVKGSNAVITPAGVVKLIDFGCAQRVALALSCHE--------NGGLHSVHGTAYWMAPEVINGTGYARRADVWSLGCTLHEMAVGRPPFADMAPMAALLHIGIRNGIMPGLPQAFSKEAQEFVEQCFIRDKLKRPSSQELLSHPFI 283
[Close]
BLAST of Mitogen-activated protein kinase kinase kinase 3 vs. Ensembl Sea Lamprey
Match: ENSPMAT00000002962.1 (pep scaffold:Pmarinus_7.0:GL476671:16080:33623:-1 gene:ENSPMAG00000002691.1 transcript:ENSPMAT00000002962.1 gene_biotype:protein_coding transcript_biotype:protein_coding)

HSP 1 Score: 117.087 bits (292), Expect = 3.041e-27
Identity = 92/275 (33.45%), Postives = 144/275 (52.36%), Query Frame = 2 
Query: 1457 VGEGGFGKVYQCEDLATNKVMAVKEIKIP---KNKKLSDVTSAIKEILTFSKLECHQRIIQYFDFFQKDEKTFCITMEYMANGSLSSYLEING-PLEEREIARISTQVLEGLLYLHNNQILHRDIKGGNIXXXXXXXXXXXXFGLSKCSEEISGWDFYTGILQSNVGTQNWTAPEV---LNDEAYGLKADIWSFGATVVEMVVGERPYADYESVQLTFKLLTDKKIEFTPPKTMTRQLEEFIAWCLKPEPHERPTAQLLLNSDFIKLNK*NLVLI 2260
            +G G FG VY   ++ T++V+A+K++       N+K  D+   IKE+   +KL+ H  II+Y   + + E T  + MEY   GS S  LE++  PL+E EIA I+   L+GL +LHN+ ++HRD+K GNILL +    KLADFG +            T    S VGT  W APEV   +++  Y  K D+WS G T +E+   + P  +  ++   + +  +       P+  +     F+  CL+    +RPT+  LL   F+  ++   VLI
Sbjct:   36 IGHGSFGAVYFARNIHTSEVVAIKKMSYSGKQSNEKWQDI---IKEVKFLTKLK-HPNIIEYKGCYLR-EHTAWMIMEYCL-GSASDLLEVHKKPLQEIEIAAIAHGALQGLAFLHNHTMIHRDVKAGNILLTEPGQVKLADFGSAS----------LTAPANSFVGTPYWMAPEVILAMDEGQYDGKVDVWSLGITCIELAERKPPLFNMNAMSALYHIAQNDSPTLQSPE-WSDYFRNFVDSCLQKNGQDRPTSAGLLRHAFVMRDRPESVLI 293
[Close]
BLAST of Mitogen-activated protein kinase kinase kinase 3 vs. Ensembl Yeast
Match: BCK1 (MAPKKK acting in the protein kinase C signaling pathway; the kinase C signaling pathway controls cell integrity; upon activation by Pkc1p phosphorylates downstream kinases Mkk1p and Mkk2p; MAPKKK is an acronym for mitogen-activated protein (MAP) kinase kinase kinase [Source:SGD;Acc:S000003631])

HSP 1 Score: 158.688 bits (400), Expect = 2.405e-40
Identity = 99/270 (36.67%), Postives = 155/270 (57.41%), Query Frame = 2 
Query: 1457 VGEGGFGKVYQCEDLATNKVMAVKEIKIPKNKK-----LSDVTSAIKEILTFSKLECHQRIIQYFDFFQKDEKTFCITMEYMANGSLSSYLEINGPLEEREIARISTQVLEGLLYLHNNQILHRDIKGGNIXXXXXXXXXXXXFGLSKCSEEISGWDFYTGILQSNVGTQNWTAPEVLN-DEAYGLKADIWSFGATVVEMVVGERPYADYESVQLTFKLLTDKKIEFTPPKTM---TRQLEEFIAWCLKPEPHERPTAQLLLNSDFIKLN 2239
            +G+G FG VY C ++ T ++MAVK++++PK        LS V +   E+ T   L+ H  I+QY  F  K+   + + +EY+A GS+ S + + G  +E  I  ++TQVL+GL YLH+  ILHRD+K  N+LLD     K++DFG+S+ S++I     Y+    +  GT  W APE+++  + Y  K DIWS G  V+EM  G+RP+++ E V   FK+   K     P  T+   ++    F+  C +  P +RPTA  LL+  F ++N
Sbjct: 1181 IGKGSFGAVYLCLNVTTGEMMAVKQVEVPKYSSQNEAILSTVEALRSEVSTLKDLD-HLNIVQYLGFENKNN-IYSLFLEYVAGGSVGSLIRMYGRFDEPLIKHLTTQVLKGLAYLHSKGILHRDMKADNLLLDQDGICKISDFGISRKSKDI-----YSNSDMTMRGTVFWMAPEMVDTKQGYSAKVDIWSLGCIVLEMFAGKRPWSNLEVVAAMFKIGKSKSAPPIPEDTLPLISQIGRNFLDACFEINPEKRPTANELLSHPFSEVN 1443
[Close]
BLAST of Mitogen-activated protein kinase kinase kinase 3 vs. Ensembl Yeast
Match: CDC15 (Protein kinase of the Mitotic Exit Network; localized to the spindle pole bodies at late anaphase; promotes mitotic exit by directly switching on the kinase activity of Dbf2p; required for spindle disassembly after meiosis II; relocalizes to the cytoplasm upon DNA replication stress [Source:SGD;Acc:S000000072])

HSP 1 Score: 135.576 bits (340), Expect = 3.186e-33
Identity = 86/254 (33.86%), Postives = 133/254 (52.36%), Query Frame = 2 
Query: 1457 VGEGGFGKVYQCEDLATNKVMAVKEIKIPKNKKLSDVTSAIKEILTFSKLECHQRIIQYFDFFQKDEKTFCITMEYMANGSLSSYLEINGP-LEEREIARISTQVLEGLLYLHNNQILHRDIKGGNIXXXXXXXXXXXXFGLSKCSEEISGWDFYTGILQSNVGTQNWTAPEVLNDEAYGLKADIWSFGATVVEMVVGERPYADYESVQLTFKLLTDKKIEFTPPKTMTRQLEEFIAWCLKPEPHERPTAQLLL 2215
            +G G +G VY+  +  T++V+A+KE+    +++L+D+ + I  +   +    H  I++Y  F +K  + + I +EY ANGSL   +  +   L E E     TQ L GL YLH   ++HRDIK  NILL      KLADFG+S      +          +  GT NW APE+L +      +DIWS GATVVEM+    PY +     + + +  D    + PP + +  L++F++ C     ++RPTA  LL
Sbjct:   31 IGRGSYGVVYKAINKHTDQVVAIKEVVYENDEELNDIMAEISLLKNLN----HNNIVKYHGFIRKSYELY-ILLEYCANGSLRRLISRSSTGLSENESKTYVTQTLLGLKYLHGEGVIHRDIKAANILLSADNTVKLADFGVSTIVNSSA---------LTLAGTLNWMAPEILGNRGASTLSDIWSLGATVVEMLTKNPPYHNLTDANIYYAVEND---TYYPPSSFSEPLKDFLSKCFVKNMYKRPTADQLL 267
[Close]
BLAST of Mitogen-activated protein kinase kinase kinase 3 vs. Ensembl Yeast
Match: STE20 (Cdc42p-activated signal transducing kinase; involved in pheromone response, pseudohyphal/invasive growth, vacuole inheritance, down-regulation of sterol uptake; GBB motif binds Ste4p; member of the PAK (p21-activated kinase) family [Source:SGD;Acc:S000000999])

HSP 1 Score: 134.42 bits (337), Expect = 6.409e-33
Identity = 91/269 (33.83%), Postives = 147/269 (54.65%), Query Frame = 2 
Query: 1424 SKLENIVNQDPVGEGGFGKVYQCEDLATNKVMAVKEIKIPKNKKLSDVTSAIKEILTFSKLECHQRIIQYFDFFQKDEKTFCITMEYMANGSLSSYLEINGPLEEREIARISTQVLEGLLYLHNNQILHRDIKGGNIXXXXXXXXXXXXFGLSKCSEEISGWDFYTGILQSNVGTQNWTAPEVLNDEAYGLKADIWSFGATVVEMVVGERPYADYESVQLTFKLLTDKKIEFTPPKTMTRQLEEFIAWCLKPEPHERPTAQLLLNSDFI 2230
            +K  N+V    +G+G  G VY   ++ TN  +A+K++ + K  K   +   I EIL   K   H  I+ + D +      + I MEYM  GSL+  +  +  L E +I  +  + L GL +LH+  +LHRDIK  NILL  + + KL DFG   C++ I+  +     +   VGT  W APEV++ + YG K DIWS G  ++EM+ GE PY +   ++  + + T+   +   P+ ++  L++F+ WCL  EP +R +A  LL+ ++I
Sbjct:  618 TKYANLVK---IGQGASGGVYTAYEIGTNVSVAIKQMNLEKQPKKELI---INEILVM-KGSKHPNIVNFIDSYVLKGDLWVI-MEYMEGGSLTDVV-THCILTEGQIGAVCRETLSGLEFLHSKGVLHRDIKSDNILLSMEGDIKLTDFGF--CAQ-INELNLKRTTM---VGTPYWMAPEVVSRKEYGPKVDIWSLGIMIIEMIEGEPPYLNETPLRALYLIATNGTPKLKEPENLSSSLKKFLDWCLCVEPEDRASATELLHDEYI 871
[Close]
BLAST of Mitogen-activated protein kinase kinase kinase 3 vs. Ensembl Yeast
Match: STE11 (Signal transducing MEK kinase; involved in pheromone response and pseudohyphal/invasive growth pathways where it phosphorylates Ste7p, and the high osmolarity response pathway, via phosphorylation of Pbs2p; regulated by Ste20p and Ste50p; protein abundance increases in response to DNA replication stress [Source:SGD;Acc:S000004354])

HSP 1 Score: 124.02 bits (310), Expect = 9.954e-30
Identity = 93/293 (31.74%), Postives = 137/293 (46.76%), Query Frame = 2 
Query: 1457 VGEGGFGKVYQCEDLATNKVMAVKEIKIPKNK------------------------KLSDVTS----------------AIKEILTFSKLECHQRIIQYFDFFQKDEKTFCITMEYMANGSLSSYLEINGPLEEREIARISTQVLEGLLYLHNNQILHRDIKGGNIXXXXXXXXXXXXFGLSKCSEEISGWDFYTGILQSNVGTQNWTAPEVLNDEAYGLKADIWSFGATVVEMVVGERPYADYESVQLTFKLLTDKKIEFTPPKTMTRQLEEFIAWCLKPEPHERPTAQLLL 2215
            +G G FG VY   +  T ++MAVK+++I  N                         K+ DV +                A++  +   K   H+ I+ Y+   Q +     I +EY+  GS+SS L   GP EE  I   + Q+L G+ YLH   I+HRDIKG NIL+D K   K+ DFG+SK    ++        LQ   G+  W +PEV+   A   KADIWS G  V+EM  G+ P+ D+  +Q  FK+ T+   E   P   T + + F+    + +   RP+A  LL
Sbjct:  421 IGSGSFGSVYLGMNAHTGELMAVKQVEIKNNNIGVPTDNNKQANSDENNEQEEQQEKIEDVGAVSHPKTNQNIHRKMVDALQHEMNLLKELHHENIVTYYGASQ-EGGNLNIFLEYVPGGSVSSMLNNYGPFEESLITNFTRQILIGVAYLHKKNIIHRDIKGANILIDIKGCVKITDFGISKKLSPLNKKQNKRASLQ---GSVFWMSPEVVKQTATTAKADIWSTGCVVIEMFTGKHPFPDFSQMQAIFKIGTNTTPEI--PSWATSEGKNFLRKAFELDYQYRPSALELL 707
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BLAST of Mitogen-activated protein kinase kinase kinase 3 vs. Ensembl Yeast
Match: KIC1 (Protein kinase of the PAK/Ste20 family, required for cell integrity; physically interacts with Cdc31p (centrin), which is a component of the spindle pole body; part of the RAM network that regulates cellular polarity and morphogenesis [Source:SGD;Acc:S000001144])

HSP 1 Score: 124.405 bits (311), Expect = 1.370e-29
Identity = 89/263 (33.84%), Postives = 140/263 (53.23%), Query Frame = 2 
Query: 1457 VGEGGFGKVYQCEDLATNKVMAVKEIKIPKNKKLSDVTSAIKEILTFSKLECHQRIIQYFDFFQKDEKTFCITMEYMANGSLSSYLEINGPLEEREIARISTQVLEGLLYLHNNQILHRDIKGGNIXXXXXXXXXXXXFGLSKCSEEISGWDFYTGILQSNVGTQNWTAPEVLNDEAY-GLKADIWSFGATVVEMVVGERPYADYESVQLTFKLLTDKKIEFTPPKTMTRQLEEFIAWCLKPEPHERPTAQLLLNSDFIKLNK 2242
            +G G FG VY+  ++ T +V A+K + +  +    +V    +EI   + L+    I +Y+  + KD  +  I ME+ A GSL S L   G ++E+ I  I  ++L  L  +H + ++HRDIK  N+L+ ++ N KL DFG++    + S         Q+  GT  W APEV+ +  Y   K DIWS G T  E+  G  PY D E+++   +L+   K      ++ +  L+EFIA CL  +P ER +A  LL S FI+ +K
Sbjct:   29 IGRGKFGVVYKGYNVKTGRVYAIKVLNL--DSDSDEVEDVQREIQFLASLKQISNITRYYGSYLKD-TSLWIIMEHCAGGSLRSLLRP-GKIDEKYIGVIMRELLVALKCIHKDNVIHRDIKAANVLITNEGNVKLCDFGVAAQVNQTSLR------RQTMAGTPYWMAPEVIMEGVYYDTKVDIWSLGITTYEIATGNPPYCDVEALR-AMQLIIKSKPPRLEDRSYSTSLKEFIALCLDEDPKERLSADDLLKSKFIRAHK 280
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BLAST of Mitogen-activated protein kinase kinase kinase 3 vs. Ensembl Nematostella
Match: EDO41410 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7S4G7])

HSP 1 Score: 169.088 bits (427), Expect = 1.936e-47
Identity = 106/259 (40.93%), Postives = 151/259 (58.30%), Query Frame = 2 
Query: 1457 VGEGGFGKVYQCEDLATNKVMAVKEIKIPK-NKKLSDVTSAIKEILTFSKLECHQRIIQYFDFFQKDEKTFCITMEYMANGSLSSYLEINGPLEEREIARISTQVLEGLLYLHNNQILHRDIKGGNIXXXXXXXXXXXXFGLSKCSEEISGWDFYTGILQSNVGTQNWTAPEVLNDEAYGLKADIWSFGATVVEMVVGERPYADYESVQLTFKLLTDKKIEFTPPKTMTRQLEEFIAWCLKPEPHERPTAQLLLNSDFI 2230
            +G G FG+VY C DL T + +AVK+I+  + N    +   A++  + F K   ++RI+QY+   + D+    I MEY+  GS+  +++ +G L E    + S Q+LEG+LYLH N+I+HRDIKG NIL D   N KLADFG SK  + I      TG  +S  GT  W APEV+N E YG KAD+WS G TVVEM+  + P+AD+E +   FK+ T +  E   P  ++    EF+   L+     RP+A  LL   F+
Sbjct:   10 LGAGAFGQVYMCHDLDTGRELAVKQIETGQLNSSTKNEVKALEGEIEFMKAFRNERIVQYYGI-ETDDLHIYIFMEYLPGGSIHEHIKQHGALNESLTRKYSRQILEGILYLHTNRIVHRDIKGANILRDLYGNVKLADFGASKRLQTIRS---KTG-FRSVHGTPYWMAPEVINGEGYGRKADVWSVGCTVVEMLTTKPPWADFEPMAALFKIAT-QPTEPELPSDLSVDAVEFVRSTLRMNSKSRPSADELLRFSFV 262
[Close]
BLAST of Mitogen-activated protein kinase kinase kinase 3 vs. Ensembl Nematostella
Match: EDO31934 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7SWI4])

HSP 1 Score: 135.576 bits (340), Expect = 1.927e-34
Identity = 99/281 (35.23%), Postives = 156/281 (55.52%), Query Frame = 2 
Query: 1421 LSKLENIVNQDPVGEGGFGKVYQCEDLATNKVMAVKEIKIPKNKKLSDVTSAIKEILTFSKLECHQRIIQYFDFFQKDEKTFCITMEYMANGSLSSYLEINGPLEEREIARISTQVLEGLLYLHNNQILHRDIKGGNIXXXXXXXXXXXXFGLS-KCSEEISGWDFYTGILQSNVGTQNWTAPEVLNDEAYGLKADIWSFGATVVEMVVGERPYADYESVQLTFKLLTDKKIEFTPPKTMTRQLEEFIAWCLKPEPHERPTAQLLLNSDFIKLNK*NLVLI 2260
             SKLE I      G+G FG+V++  D  TN+V+A+K I + + +   +     +EI   S+ +    + +Y   + K  K + I MEY+  GS    ++  G +EE  IA I  +VL+GL YLH  + LHRDIK  N+L+ +  + KLADFG++ + ++ ++  + +       VGT  W APEV+   AY  KADIWS G T +E+  GE P +D   +++ F +  +   E T     ++  +EF++ CL  +P++RPTA+ LL   FIK  K N  L+
Sbjct:   11 FSKLERI------GKGSFGEVFKGIDNRTNEVVAIKIIDLEEAEDEIEDIQ--QEITVLSQCDS-LYVTKYHGSYLKGTKLWII-MEYLGGGSALDLMKA-GNIEEFYIATILREVLKGLDYLHTEKKLHRDIKAANVLMSETGDVKLADFGVAGQLTDTLNKRNTF-------VGTPFWMAPEVIKQSAYDSKADIWSLGITAIELAKGEPPNSDLHPMRVLFLIPKNNPPELT--GNFSKAFKEFVSLCLNKDPNDRPTAKELLKHRFIKTAKKNAYLV 271
[Close]
BLAST of Mitogen-activated protein kinase kinase kinase 3 vs. Ensembl Nematostella
Match: EDO47821 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7RL88])

HSP 1 Score: 131.724 bits (330), Expect = 2.895e-34
Identity = 85/262 (32.44%), Postives = 141/262 (53.82%), Query Frame = 2 
Query: 1457 VGEGGFGKVYQCEDLATNKVMAVKEIKI-PKNKKLSDVT-SAIKEILTFSKLECHQRIIQYFDFFQKDEK-TFCITMEYMANGSLSSYLEINGPLEEREIARISTQVLEGLLYLHNNQILHRDIKGGNIXXXXXXXXXXXXFGLSKCSEEISGWDFYTGILQSNVGTQNWTAPEVLNDEAYGLKADIWSFGATVVEMVVGERPYADYESVQLTFKLLTDKKIEFTPPKTMTRQLEEFIAWCLKPEPHERPTAQLLLNSDFIK 2233
            +G+G FG V+    + T +++AVK++++ P N   ++     ++E +   K   H+ I+QY      D + T  I ME++  GS++  L+  G   E    R + Q+L+G+ YLHNN ++HRDIKGGNI+L      KL DFG +K    +      + IL+S  GT  W APEV+ +  +G K+DIWS G TV EM  G+ P+++   +   F +     +     ++ +    +F+  C+  +   RP+A  LL  DF++
Sbjct:   11 LGKGAFGTVF-LGLVNTGELIAVKQVELHPNNVDAAERQYEKLQEEVGLLKSLKHKNIVQYIGTCMDDSQCTINIFMEFVPGGSIAQALKRFGAFVEPVFRRYTRQILDGVSYLHNNNVIHRDIKGGNIMLMPNGVIKLIDFGCAKKICMVGAHVSKSNILRSMRGTPYWMAPEVIRETGHGRKSDIWSIGCTVFEMATGQPPWSNVPPLSAIFAIGNGSPVPRL-DESFSAAAIDFVTSCMTRDQDTRPSADELLRHDFLQ 270
[Close]
BLAST of Mitogen-activated protein kinase kinase kinase 3 vs. Ensembl Nematostella
Match: EDO42845 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7S0A9])

HSP 1 Score: 131.724 bits (330), Expect = 9.383e-34
Identity = 90/264 (34.09%), Postives = 142/264 (53.79%), Query Frame = 2 
Query: 1457 VGEGGFGKVYQCEDLATNKVMAVKEIKIPKNKKLSDVTSAIKEILTFSKLECHQRIIQYFDFFQKDEKTFCITMEYMANGSLSSYLEI-NGPLEEREIARISTQVLEGLLYLHNNQILHRDIKGGNIXXXXXXXXXXXXFGLS-KCSEEISGWDFYTGILQSNVGTQNWTAPEVLNDEAYGLKADIWSFGATVVEMVVGERPYADYESVQLTFKLLTDKKIEFTPPKTMTRQLEEFIAWCLKPEPHERPTAQLLLNSDFIKLNK 2242
            +GEG +G V++     + +V+A+K++ +      +D+   IKEI    + +    +  Y  +F+  +    I MEY   GS+S  ++I N  L E EI  +    L+GL YLH  + +HRDIK GNILL+ + +AKLADFG++ + ++ ++  +       + +GT  W APEV+ +  Y   ADIWS G T +EM  G+ PYAD   ++  F + T     F  P   +   ++F++ CL   P ER TA  LL   FI+  K
Sbjct:   30 LGEGSYGSVFKAMHKESGQVVAIKQVPVD-----TDLQEIIKEISMMQQCDSPYVVKYYGSYFKNTD--LWIVMEYCGAGSVSDLMKIRNKTLTEEEIKCVLKYTLKGLEYLHLRRKIHRDIKAGNILLNSEGHAKLADFGVAGQLTDTMAKRN-------TVIGTPFWMAPEVIQEVGYDCLADIWSLGITAMEMAEGKPPYADIHPMRAIFMIPTKPPPTFRDPGQWSEDFKDFVSKCLVKNPEERATATELLQHSFIQGAK 279
[Close]
BLAST of Mitogen-activated protein kinase kinase kinase 3 vs. Ensembl Nematostella
Match: EDO36150 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7SJF2])

HSP 1 Score: 131.724 bits (330), Expect = 1.399e-31
Identity = 88/265 (33.21%), Postives = 140/265 (52.83%), Query Frame = 2 
Query: 1457 VGEGGFGKVYQCEDLATNKVMAVKEIKIPKNKKLSD---VTSAIKEILTFSKLECHQRIIQYFDFFQKDEKTFCITMEYMANGSLSSYLEINGPLEEREIARISTQVLEGLLYLHNNQILHRDIKGGNIXX-XXXXXXXXXXFG-LSKCSEEISGWDFYTGILQSNVGTQNWTAPEVLNDEAYGLKADIWSFGATVVEMVVGERPYADYE---SVQLTFKLLTDKKIEFTP---PKTMTRQLEEFIAWCLKPEPHERPTAQLLLN 2218
            +G G F   Y   D+ T  +MAVK++   +N K        + + EI   ++L+ H  +I+      +    F I +E+MA GS+S  L   GP EE  + R   Q+L+G+ YLH NQ++HRDIKG NIL+     + ++ADFG  ++ + +I+G   + G L   +GT  + APEVL  E+YG   D+WS G  ++EM  G+ P+  +E    + L FK+         P   P+ +   + + +  CL+ +P +RP A  LL 
Sbjct:  583 LGTGAFSSCYGARDVMTGSLMAVKQVSFCRNSKSEQDKVCQTIMDEIAILARLK-HPHLIKCLGA-TRHTGHFNIFLEWMAGGSISMLLSKYGPFEEAILIRYLRQILQGVSYLHENQVVHRDIKGANILVDSTGQDIRIADFGAAARLATQITGAGEFQGQL---LGTIAFMAPEVLRGESYGRSCDVWSVGCVLIEMATGKPPWNAHEHSNHLALIFKI----ACAIGPPDIPEHLNPGVRDVVLRCLESKPEDRPAAVDLLQ 838
[Close]
BLAST of Mitogen-activated protein kinase kinase kinase 3 vs. Ensembl Medaka
Match: map3k3 (mitogen-activated protein kinase kinase kinase 3 [Source:NCBI gene;Acc:101169290])

HSP 1 Score: 170.629 bits (431), Expect = 1.550e-44
Identity = 109/264 (41.29%), Postives = 154/264 (58.33%), Query Frame = 2 
Query: 1457 VGEGGFGKVYQCEDLATNKVMAVKEIKI-PKNKKLSDVTSAIKEILTFSKLECHQRIIQYFDFFQ-KDEKTFCITMEYMANGSLSSYLEINGPLEEREIARISTQVLEGLLYLHNNQILHRDIKGGNIXXXXXXXXXXXXFGLSKCSEEI--SGWDFYTGILQSNVGTQNWTAPEVLNDEAYGLKADIWSFGATVVEMVVGERPYADYESVQLTFKLLTDKKIEFTPPKTMTRQLEEFIAWCLKPEPHERPTAQLLLNSDFIKL 2236
            +G+G FG VY C D+ T + +A K+++  P + + S   SA++  +   K   H+RI+QY+   +   EKT  I MEYM  GS+   L+  G L E    + + Q+LEG+ YLH+N I+HRDIKG NIL D   N KL DFG SK  + I  SG    TGI +S  GT  W +PEV++ E YG KAD+WS G TVVEM+  + P+A+YE++   FK+ T       P  T + Q  +FI  C+  E   RP+A+ LL   F ++
Sbjct:  359 LGQGAFGLVYLCYDVDTGRELAAKQVQFDPDSPETSKEVSALECEIQLLKNLHHERIVQYYGCLRDHSEKTLTIFMEYMPGGSVKDQLKAYGALTENVTRKYTRQILEGMSYLHSNMIVHRDIKGANILRDSAGNVKLGDFGASKRLQTICMSG----TGI-RSVTGTPYWMSPEVISGEGYGRKADVWSLGCTVVEMLTEKPPWAEYEAMAAIFKIATQPTNPLLPSHT-SDQARDFIH-CIFVEAKHRPSAEELLRHPFSQI 615
[Close]
BLAST of Mitogen-activated protein kinase kinase kinase 3 vs. Ensembl Medaka
Match: map3k2 (mitogen-activated protein kinase kinase kinase 2 [Source:NCBI gene;Acc:101160297])

HSP 1 Score: 164.851 bits (416), Expect = 1.896e-42
Identity = 106/262 (40.46%), Postives = 153/262 (58.40%), Query Frame = 2 
Query: 1457 VGEGGFGKVYQCEDLATNKVMAVKEIKI-PKNKKLSDVTSAIKEILTFSKLECHQRIIQYFDFFQKD-EKTFCITMEYMANGSLSSYLEINGPLEEREIARISTQVLEGLLYLHNNQILHRDIKGGNIXXXXXXXXXXXXFGLSKCSEEI--SGWDFYTGILQSNVGTQNWTAPEVLNDEAYGLKADIWSFGATVVEMVVGERPYADYESVQLTFKLLTDKKIEFTPPKTMTRQLEEFIAWCLKPEPHERPTAQLLLNSDFI 2230
            +G+G FG+VY C D  T + +AVK+++  P++ + S   SA++  +   K  CH+RI+QY+   +   E+T  I ME+M  GS+   L+  G L E    R + Q+LEG+ YLH+N I+HRDIKG NIL D   N KL DFG S+  + I  SG    TGI +S  GT  W +PEV++ E YG KADIWS G TVVEM+    P+A++E++   FK+ T +      P  ++    EF+      E  +RP+A  LL   F+
Sbjct:  395 LGQGAFGRVYLCYDADTGRELAVKQVQFDPESPETSKEVSALECEIQLLKNLCHERIVQYYGCLRDTMERTLSIFMEHMPGGSIKDQLKSYGALTENVTRRYTRQILEGVSYLHSNMIVHRDIKGANILRDSVGNVKLGDFGASRRLQTICLSG----TGI-KSVTGTPYWMSPEVISGEGYGRKADIWSVGCTVVEMLTQRPPWAEFEAMAAIFKIAT-QPTNPELPVHVSDHCREFLRRIFV-ETKQRPSADELLRHIFV 649
[Close]
BLAST of Mitogen-activated protein kinase kinase kinase 3 vs. Ensembl Medaka
Match: map3k22 (mitogen-activated protein kinase kinase kinase 3 [Source:NCBI gene;Acc:101156127])

HSP 1 Score: 159.458 bits (402), Expect = 8.231e-41
Identity = 103/263 (39.16%), Postives = 153/263 (58.17%), Query Frame = 2 
Query: 1457 VGEGGFGKVYQCEDLATNKVMAVKEIKI-PKNKKLSDVTSAIKEILTFSKLECHQRIIQYFDFFQK-DEKTFCITMEYMANGSLSSYLEINGPLEEREIARISTQVLEGLLYLHNNQILHRDIKGGNIXXXXXXXXXXXXFGLSKCSEEI--SGWDFYTGILQSNVGTQNWTAPEVLNDEAYGLKADIWSFGATVVEMVVGERPYADYESVQLTFKLLTDKKIEFTPPKTMTRQLEEFIAWCLKPEPHERPTAQLLLNSDFIK 2233
            +G G FG+VY C D  T + +A K++   P  ++ S   +A++  +   K   H RI+QY+   +  D++   I +E+M  GS+   L+  G L E+   R + Q+L+G+ YLH+N I+HRDIKG NIL D   N KL DFG SK  + I  SG    TGI +S  GT  W +PEV+N E YG KAD+WS   TVVEM+  + P+A+YE++   FK+ T +  + T P+ ++    +F+      E   RPTA +LLN  F++
Sbjct:  333 LGRGAFGEVYLCYDADTGRELAAKQVPFDPDCQETSKEVNALECEIQLLKNLRHDRIVQYYGCLRDLDQRKLTIFVEFMPGGSIKDQLKAYGALTEKVTRRYTRQILQGVSYLHSNMIVHRDIKGANILRDSSGNVKLGDFGASKRIQTICMSG----TGI-KSVTGTPYWMSPEVINGEGYGRKADVWSVACTVVEMLTQKPPWAEYEAMAAIFKIAT-QPTKPTLPEGVSDASRDFLRQVFV-EEKWRPTADILLNHPFVQ 588
[Close]
BLAST of Mitogen-activated protein kinase kinase kinase 3 vs. Ensembl Medaka
Match: map3k22 (mitogen-activated protein kinase kinase kinase 3 [Source:NCBI gene;Acc:101156127])

HSP 1 Score: 159.073 bits (401), Expect = 1.214e-40
Identity = 103/263 (39.16%), Postives = 153/263 (58.17%), Query Frame = 2 
Query: 1457 VGEGGFGKVYQCEDLATNKVMAVKEIKI-PKNKKLSDVTSAIKEILTFSKLECHQRIIQYFDFFQK-DEKTFCITMEYMANGSLSSYLEINGPLEEREIARISTQVLEGLLYLHNNQILHRDIKGGNIXXXXXXXXXXXXFGLSKCSEEI--SGWDFYTGILQSNVGTQNWTAPEVLNDEAYGLKADIWSFGATVVEMVVGERPYADYESVQLTFKLLTDKKIEFTPPKTMTRQLEEFIAWCLKPEPHERPTAQLLLNSDFIK 2233
            +G G FG+VY C D  T + +A K++   P  ++ S   +A++  +   K   H RI+QY+   +  D++   I +E+M  GS+   L+  G L E+   R + Q+L+G+ YLH+N I+HRDIKG NIL D   N KL DFG SK  + I  SG    TGI +S  GT  W +PEV+N E YG KAD+WS   TVVEM+  + P+A+YE++   FK+ T +  + T P+ ++    +F+      E   RPTA +LLN  F++
Sbjct:  363 LGRGAFGEVYLCYDADTGRELAAKQVPFDPDCQETSKEVNALECEIQLLKNLRHDRIVQYYGCLRDLDQRKLTIFVEFMPGGSIKDQLKAYGALTEKVTRRYTRQILQGVSYLHSNMIVHRDIKGANILRDSSGNVKLGDFGASKRIQTICMSG----TGI-KSVTGTPYWMSPEVINGEGYGRKADVWSVACTVVEMLTQKPPWAEYEAMAAIFKIAT-QPTKPTLPEGVSDASRDFLRQVFV-EEKWRPTADILLNHPFVQ 618
[Close]
BLAST of Mitogen-activated protein kinase kinase kinase 3 vs. Ensembl Medaka
Match: map3k22 (mitogen-activated protein kinase kinase kinase 3 [Source:NCBI gene;Acc:101156127])

HSP 1 Score: 159.073 bits (401), Expect = 1.214e-40
Identity = 103/263 (39.16%), Postives = 153/263 (58.17%), Query Frame = 2 
Query: 1457 VGEGGFGKVYQCEDLATNKVMAVKEIKI-PKNKKLSDVTSAIKEILTFSKLECHQRIIQYFDFFQK-DEKTFCITMEYMANGSLSSYLEINGPLEEREIARISTQVLEGLLYLHNNQILHRDIKGGNIXXXXXXXXXXXXFGLSKCSEEI--SGWDFYTGILQSNVGTQNWTAPEVLNDEAYGLKADIWSFGATVVEMVVGERPYADYESVQLTFKLLTDKKIEFTPPKTMTRQLEEFIAWCLKPEPHERPTAQLLLNSDFIK 2233
            +G G FG+VY C D  T + +A K++   P  ++ S   +A++  +   K   H RI+QY+   +  D++   I +E+M  GS+   L+  G L E+   R + Q+L+G+ YLH+N I+HRDIKG NIL D   N KL DFG SK  + I  SG    TGI +S  GT  W +PEV+N E YG KAD+WS   TVVEM+  + P+A+YE++   FK+ T +  + T P+ ++    +F+      E   RPTA +LLN  F++
Sbjct:  363 LGRGAFGEVYLCYDADTGRELAAKQVPFDPDCQETSKEVNALECEIQLLKNLRHDRIVQYYGCLRDLDQRKLTIFVEFMPGGSIKDQLKAYGALTEKVTRRYTRQILQGVSYLHSNMIVHRDIKGANILRDSSGNVKLGDFGASKRIQTICMSG----TGI-KSVTGTPYWMSPEVINGEGYGRKADVWSVACTVVEMLTQKPPWAEYEAMAAIFKIAT-QPTKPTLPEGVSDASRDFLRQVFV-EEKWRPTADILLNHPFVQ 618
[Close]
BLAST of Mitogen-activated protein kinase kinase kinase 3 vs. Planmine SMEST
Match: SMESG000009500.1 (SMESG000009500.1)

HSP 1 Score: 1183.7 bits (3061), Expect = 0.000e+0
Identity = 591/597 (98.99%), Postives = 593/597 (99.33%), Query Frame = 2 
Query:  452 SRIPTPFIKGPKLKFRGFGKELYSDKEQIDLVKTDLSKAVRVDKNDFVLICDDMILESDDWIKYYRIPNPVTEDVIWFGKIADYLKLNEIIIVMKSMDRSGGNSEPGSMFCIPVNIQLIVRLNQRIGEIRNHIGKIYKWIAKIPFWNFNKERLKDDQMVEESGLLNTSIIYMSTPSVVPCLNEGLTGETSDPKSFVKALGSHIIKSSVRSGMRSLFLSHLQSLPPDSKDRDRLRSIIEDITPMSYNVALSSISTDQSPMLVVGTEKITVSDCKKAVADRVKRLPEEIILIKSNQCLKDDETISNYEYSPDSYFALRSGISYFSLSKLENIVNQDPVGEGGFGKVYQCEDLATNKVMAVKEIKIPKNKKLSDVTSAIKEILTFSKLECHQRIIQYFDFFQKDEKTFCITMEYMANGSLSSYLEINGPLEEREIARISTQVLEGLLYLHNNQILHRDIKGGNIXXXXXXXXXXXXFGLSKCSEEISGWDFYTGILQSNVGTQNWTAPEVLNDEAYGLKADIWSFGATVVEMVVGERPYADYESVQLTFKLLTDKKIEFTPPKTMTRQLEEFIAWCLKPEPHERPTAQLLLNSDFIKLNK 2242
            SRIPTPFIKGPKLKFRGFGKELYSDKEQIDLVK DLSKAVRVDKNDFVLICDDMILESDDWIKYYRIPNPVTEDVIWFGKIADYLKLNEIIIVMKSMDRSGGNSEPGSMFCIPVNIQLIVRL+QRIGEIRNHIGKIYKWIAKIPFWNFNKERLKDDQMVEESGLLNTSIIYMSTPSVVPCLN+GL GETSDPKSFVKALGSHIIKSSVRSGMRSLFLSHLQSLPPDSKDRDRLRSIIEDITPMSYNVALSSISTDQSPMLVVGTEKITVSDCKKAVADRVKRLPEEIILIKSNQCLKDDETISNYEYSPDSYFALRSGISYF LSKLENIVNQDPVGEGGFGKVYQCEDLATNKVMAVKEIKIPKNKKLSDVTSAIKEILTFSKLECHQRIIQYFDFFQKDEKTFCITMEYMANGSLSSYLEINGPLEEREIARISTQVLEGLLYLHNNQILHRDIKGGNILLDDKLNAKLADFGLSKCSEEIS WDFYTGILQSNVGTQNWTAPEVLNDEAYGLKADIWSFGATVVEMVVGERPYADYESVQLTFKLLTDKKIEFTPPKTMTRQLEEFIAWCLKPEPHERPTAQLLLNSDFIKLNK
Sbjct:   60 SRIPTPFIKGPKLKFRGFGKELYSDKEQIDLVKMDLSKAVRVDKNDFVLICDDMILESDDWIKYYRIPNPVTEDVIWFGKIADYLKLNEIIIVMKSMDRSGGNSEPGSMFCIPVNIQLIVRLDQRIGEIRNHIGKIYKWIAKIPFWNFNKERLKDDQMVEESGLLNTSIIYMSTPSVVPCLNKGLAGETSDPKSFVKALGSHIIKSSVRSGMRSLFLSHLQSLPPDSKDRDRLRSIIEDITPMSYNVALSSISTDQSPMLVVGTEKITVSDCKKAVADRVKRLPEEIILIKSNQCLKDDETISNYEYSPDSYFALRSGISYFRLSKLENIVNQDPVGEGGFGKVYQCEDLATNKVMAVKEIKIPKNKKLSDVTSAIKEILTFSKLECHQRIIQYFDFFQKDEKTFCITMEYMANGSLSSYLEINGPLEEREIARISTQVLEGLLYLHNNQILHRDIKGGNILLDDKLNAKLADFGLSKCSEEISSWDFYTGILQSNVGTQNWTAPEVLNDEAYGLKADIWSFGATVVEMVVGERPYADYESVQLTFKLLTDKKIEFTPPKTMTRQLEEFIAWCLKPEPHERPTAQLLLNSDFIKLNK 656

HSP 2 Score: 52.373 bits (124), Expect = 1.346e-6
Identity = 32/135 (23.70%), Postives = 72/135 (53.33%), Query Frame = 2 
Query:   86 LATKFDLNSDEIVLMFNNVILDDFHRIDFYNIR---FDEIVWFGTLSDIITECDILLEIHS-DMSG------------IAERIVVNKNENINFVRAILARFHRWIMKVPLYNHKMQPIKADKSVESYGLVEFPVI 442
            L+    ++ ++ VL+ +++IL+    I +Y I     ++++WFG ++D +   +I++ + S D SG            +  +++V  ++ I  +R  + + ++WI K+P +N   + +K D+ VE  GL+   +I
Sbjct:   95 LSKAVRVDKNDFVLICDDMILESDDWIKYYRIPNPVTEDVIWFGKIADYLKLNEIIIVMKSMDRSGGNSEPGSMFCIPVNIQLIVRLDQRIGEIRNHIGKIYKWIAKIPFWNFNKERLKDDQMVEESGLLNTSII 229
[Close]
BLAST of Mitogen-activated protein kinase kinase kinase 3 vs. Planmine SMEST
Match: SMESG000009500.1 (SMESG000009500.1)

HSP 1 Score: 1182.93 bits (3059), Expect = 0.000e+0
Identity = 591/597 (98.99%), Postives = 593/597 (99.33%), Query Frame = 2 
Query:  452 SRIPTPFIKGPKLKFRGFGKELYSDKEQIDLVKTDLSKAVRVDKNDFVLICDDMILESDDWIKYYRIPNPVTEDVIWFGKIADYLKLNEIIIVMKSMDRSGGNSEPGSMFCIPVNIQLIVRLNQRIGEIRNHIGKIYKWIAKIPFWNFNKERLKDDQMVEESGLLNTSIIYMSTPSVVPCLNEGLTGETSDPKSFVKALGSHIIKSSVRSGMRSLFLSHLQSLPPDSKDRDRLRSIIEDITPMSYNVALSSISTDQSPMLVVGTEKITVSDCKKAVADRVKRLPEEIILIKSNQCLKDDETISNYEYSPDSYFALRSGISYFSLSKLENIVNQDPVGEGGFGKVYQCEDLATNKVMAVKEIKIPKNKKLSDVTSAIKEILTFSKLECHQRIIQYFDFFQKDEKTFCITMEYMANGSLSSYLEINGPLEEREIARISTQVLEGLLYLHNNQILHRDIKGGNIXXXXXXXXXXXXFGLSKCSEEISGWDFYTGILQSNVGTQNWTAPEVLNDEAYGLKADIWSFGATVVEMVVGERPYADYESVQLTFKLLTDKKIEFTPPKTMTRQLEEFIAWCLKPEPHERPTAQLLLNSDFIKLNK 2242
            SRIPTPFIKGPKLKFRGFGKELYSDKEQIDLVK DLSKAVRVDKNDFVLICDDMILESDDWIKYYRIPNPVTEDVIWFGKIADYLKLNEIIIVMKSMDRSGGNSEPGSMFCIPVNIQLIVRL+QRIGEIRNHIGKIYKWIAKIPFWNFNKERLKDDQMVEESGLLNTSIIYMSTPSVVPCLN+GL GETSDPKSFVKALGSHIIKSSVRSGMRSLFLSHLQSLPPDSKDRDRLRSIIEDITPMSYNVALSSISTDQSPMLVVGTEKITVSDCKKAVADRVKRLPEEIILIKSNQCLKDDETISNYEYSPDSYFALRSGISYF LSKLENIVNQDPVGEGGFGKVYQCEDLATNKVMAVKEIKIPKNKKLSDVTSAIKEILTFSKLECHQRIIQYFDFFQKDEKTFCITMEYMANGSLSSYLEINGPLEEREIARISTQVLEGLLYLHNNQILHRDIKGGNILLDDKLNAKLADFGLSKCSEEIS WDFYTGILQSNVGTQNWTAPEVLNDEAYGLKADIWSFGATVVEMVVGERPYADYESVQLTFKLLTDKKIEFTPPKTMTRQLEEFIAWCLKPEPHERPTAQLLLNSDFIKLNK
Sbjct:   88 SRIPTPFIKGPKLKFRGFGKELYSDKEQIDLVKMDLSKAVRVDKNDFVLICDDMILESDDWIKYYRIPNPVTEDVIWFGKIADYLKLNEIIIVMKSMDRSGGNSEPGSMFCIPVNIQLIVRLDQRIGEIRNHIGKIYKWIAKIPFWNFNKERLKDDQMVEESGLLNTSIIYMSTPSVVPCLNKGLAGETSDPKSFVKALGSHIIKSSVRSGMRSLFLSHLQSLPPDSKDRDRLRSIIEDITPMSYNVALSSISTDQSPMLVVGTEKITVSDCKKAVADRVKRLPEEIILIKSNQCLKDDETISNYEYSPDSYFALRSGISYFRLSKLENIVNQDPVGEGGFGKVYQCEDLATNKVMAVKEIKIPKNKKLSDVTSAIKEILTFSKLECHQRIIQYFDFFQKDEKTFCITMEYMANGSLSSYLEINGPLEEREIARISTQVLEGLLYLHNNQILHRDIKGGNILLDDKLNAKLADFGLSKCSEEISSWDFYTGILQSNVGTQNWTAPEVLNDEAYGLKADIWSFGATVVEMVVGERPYADYESVQLTFKLLTDKKIEFTPPKTMTRQLEEFIAWCLKPEPHERPTAQLLLNSDFIKLNK 684

HSP 2 Score: 51.9878 bits (123), Expect = 1.572e-6
Identity = 32/135 (23.70%), Postives = 72/135 (53.33%), Query Frame = 2 
Query:   86 LATKFDLNSDEIVLMFNNVILDDFHRIDFYNIR---FDEIVWFGTLSDIITECDILLEIHS-DMSG------------IAERIVVNKNENINFVRAILARFHRWIMKVPLYNHKMQPIKADKSVESYGLVEFPVI 442
            L+    ++ ++ VL+ +++IL+    I +Y I     ++++WFG ++D +   +I++ + S D SG            +  +++V  ++ I  +R  + + ++WI K+P +N   + +K D+ VE  GL+   +I
Sbjct:  123 LSKAVRVDKNDFVLICDDMILESDDWIKYYRIPNPVTEDVIWFGKIADYLKLNEIIIVMKSMDRSGGNSEPGSMFCIPVNIQLIVRLDQRIGEIRNHIGKIYKWIAKIPFWNFNKERLKDDQMVEESGLLNTSII 257
[Close]
BLAST of Mitogen-activated protein kinase kinase kinase 3 vs. Planmine SMEST
Match: SMESG000009500.1 (SMESG000009500.1)

HSP 1 Score: 869.766 bits (2246), Expect = 0.000e+0
Identity = 464/597 (77.72%), Postives = 484/597 (81.07%), Query Frame = 2 
Query:  452 SRIPTPFIKGPKLKFRGFGKELYSDKEQIDLVKTDLSKAVRVDKNDFVLICDDMILESDDWIKYYRIPNPVTEDVIWFGKIADYLKLNEIIIVMKSMDRSGGNSEPGSMFCIPVNIQLIVRLNQRIGEIRNHIGKIYKWIAKIPFWNFNKERLKDDQMVEESGLLNTSIIYMSTPSVVPCLNEGLTGETSDPKSFVKALGSHIIKSSVRSGMRSLFLSHLQSLPPDSKDRDRLRSIIEDITPMSYNVALSSISTDQSPMLVVGTEKITVSDCKKAVADRVKRLPEEIILIKSNQCLKDDETISNYEYSPDSYFALRSGISYFSLSKLENIVNQDPVGEGGFGKVYQCEDLATNKVMAVKEIKIPKNKKLSDVTSAIKEILTFSKLECHQRIIQYFDFFQKDEKTFCITMEYMANGSLSSYLEINGPLEEREIARISTQVLEGLLYLHNNQILHRDIKGGNIXXXXXXXXXXXXFGLSKCSEEISGWDFYTGILQSNVGTQNWTAPEVLNDEAYGLKADIWSFGATVVEMVVGERPYADYESVQLTFKLLTDKKIEFTPPKTMTRQLEEFIAWCLKPEPHERPTAQLLLNSDFIKLNK 2242
            SRIPTPFIKGPKLKFRGFGKELYSDKEQIDLVK DLSKAVRVDKNDFVLICDDMILESDDWIKYYRIPNPVTEDVIWFGKIADYLKLNEIIIVMKSMDRSGGNSEPGSMFCIPVNIQLIVRL+QRIGEIRNHIGKIYKWIAKIPFWNFNKERLKDDQMVEESGLLNTSIIYMSTP      N  L+  ++D    +      I  S  +  +                  DR++ + E+I  +  N  L               +  T+S+ + +        P+    ++S                  SYF L         SKLENIVNQDPVGEGGFGKVYQCEDLATNKVMAVKEIKIPKNKKLSDVTSAIKEILTFSKLECHQRIIQYFDFFQKDEKTFCITMEYMANGSLSSYLEINGPLEEREIARISTQVLEGLLYLHNNQILHRDIKGGNILLDDKLNAKLADFGLSKCSEEIS WDFYTGILQSNVGTQNWTAPEVLNDEAYGLKADIWSFGATVVEMVVGERPYADYESVQLTFKLLTDKKIEFTPPKTMTRQLEEFIAWCLKPEPHERPTAQLLLNSDFIKLNK
Sbjct:   60 SRIPTPFIKGPKLKFRGFGKELYSDKEQIDLVKMDLSKAVRVDKNDFVLICDDMILESDDWIKYYRIPNPVTEDVIWFGKIADYLKLNEIIIVMKSMDRSGGNSEPGSMFCIPVNIQLIVRLDQRIGEIRNHIGKIYKWIAKIPFWNFNKERLKDDQMVEESGLLNTSIIYMSTPM---SYNVALSSISTDQSPMLVVGTEKITVSDCKKAV-----------------ADRVKRLPEEIILIKSNQCLK--------------DDETISNYEYS--------PDSYFALRSGI----------------SYFRL---------SKLENIVNQDPVGEGGFGKVYQCEDLATNKVMAVKEIKIPKNKKLSDVTSAIKEILTFSKLECHQRIIQYFDFFQKDEKTFCITMEYMANGSLSSYLEINGPLEEREIARISTQVLEGLLYLHNNQILHRDIKGGNILLDDKLNAKLADFGLSKCSEEISSWDFYTGILQSNVGTQNWTAPEVLNDEAYGLKADIWSFGATVVEMVVGERPYADYESVQLTFKLLTDKKIEFTPPKTMTRQLEEFIAWCLKPEPHERPTAQLLLNSDFIKLNK 589

HSP 2 Score: 52.373 bits (124), Expect = 1.134e-6
Identity = 32/135 (23.70%), Postives = 72/135 (53.33%), Query Frame = 2 
Query:   86 LATKFDLNSDEIVLMFNNVILDDFHRIDFYNIR---FDEIVWFGTLSDIITECDILLEIHS-DMSG------------IAERIVVNKNENINFVRAILARFHRWIMKVPLYNHKMQPIKADKSVESYGLVEFPVI 442
            L+    ++ ++ VL+ +++IL+    I +Y I     ++++WFG ++D +   +I++ + S D SG            +  +++V  ++ I  +R  + + ++WI K+P +N   + +K D+ VE  GL+   +I
Sbjct:   95 LSKAVRVDKNDFVLICDDMILESDDWIKYYRIPNPVTEDVIWFGKIADYLKLNEIIIVMKSMDRSGGNSEPGSMFCIPVNIQLIVRLDQRIGEIRNHIGKIYKWIAKIPFWNFNKERLKDDQMVEESGLLNTSII 229
[Close]
BLAST of Mitogen-activated protein kinase kinase kinase 3 vs. Planmine SMEST
Match: SMESG000009500.1 (SMESG000009500.1)

HSP 1 Score: 868.996 bits (2244), Expect = 0.000e+0
Identity = 464/597 (77.72%), Postives = 484/597 (81.07%), Query Frame = 2 
Query:  452 SRIPTPFIKGPKLKFRGFGKELYSDKEQIDLVKTDLSKAVRVDKNDFVLICDDMILESDDWIKYYRIPNPVTEDVIWFGKIADYLKLNEIIIVMKSMDRSGGNSEPGSMFCIPVNIQLIVRLNQRIGEIRNHIGKIYKWIAKIPFWNFNKERLKDDQMVEESGLLNTSIIYMSTPSVVPCLNEGLTGETSDPKSFVKALGSHIIKSSVRSGMRSLFLSHLQSLPPDSKDRDRLRSIIEDITPMSYNVALSSISTDQSPMLVVGTEKITVSDCKKAVADRVKRLPEEIILIKSNQCLKDDETISNYEYSPDSYFALRSGISYFSLSKLENIVNQDPVGEGGFGKVYQCEDLATNKVMAVKEIKIPKNKKLSDVTSAIKEILTFSKLECHQRIIQYFDFFQKDEKTFCITMEYMANGSLSSYLEINGPLEEREIARISTQVLEGLLYLHNNQILHRDIKGGNIXXXXXXXXXXXXFGLSKCSEEISGWDFYTGILQSNVGTQNWTAPEVLNDEAYGLKADIWSFGATVVEMVVGERPYADYESVQLTFKLLTDKKIEFTPPKTMTRQLEEFIAWCLKPEPHERPTAQLLLNSDFIKLNK 2242
            SRIPTPFIKGPKLKFRGFGKELYSDKEQIDLVK DLSKAVRVDKNDFVLICDDMILESDDWIKYYRIPNPVTEDVIWFGKIADYLKLNEIIIVMKSMDRSGGNSEPGSMFCIPVNIQLIVRL+QRIGEIRNHIGKIYKWIAKIPFWNFNKERLKDDQMVEESGLLNTSIIYMSTP      N  L+  ++D    +      I  S  +  +                  DR++ + E+I  +  N  L               +  T+S+ + +        P+    ++S                  SYF L         SKLENIVNQDPVGEGGFGKVYQCEDLATNKVMAVKEIKIPKNKKLSDVTSAIKEILTFSKLECHQRIIQYFDFFQKDEKTFCITMEYMANGSLSSYLEINGPLEEREIARISTQVLEGLLYLHNNQILHRDIKGGNILLDDKLNAKLADFGLSKCSEEIS WDFYTGILQSNVGTQNWTAPEVLNDEAYGLKADIWSFGATVVEMVVGERPYADYESVQLTFKLLTDKKIEFTPPKTMTRQLEEFIAWCLKPEPHERPTAQLLLNSDFIKLNK
Sbjct:   88 SRIPTPFIKGPKLKFRGFGKELYSDKEQIDLVKMDLSKAVRVDKNDFVLICDDMILESDDWIKYYRIPNPVTEDVIWFGKIADYLKLNEIIIVMKSMDRSGGNSEPGSMFCIPVNIQLIVRLDQRIGEIRNHIGKIYKWIAKIPFWNFNKERLKDDQMVEESGLLNTSIIYMSTPM---SYNVALSSISTDQSPMLVVGTEKITVSDCKKAV-----------------ADRVKRLPEEIILIKSNQCLK--------------DDETISNYEYS--------PDSYFALRSGI----------------SYFRL---------SKLENIVNQDPVGEGGFGKVYQCEDLATNKVMAVKEIKIPKNKKLSDVTSAIKEILTFSKLECHQRIIQYFDFFQKDEKTFCITMEYMANGSLSSYLEINGPLEEREIARISTQVLEGLLYLHNNQILHRDIKGGNILLDDKLNAKLADFGLSKCSEEISSWDFYTGILQSNVGTQNWTAPEVLNDEAYGLKADIWSFGATVVEMVVGERPYADYESVQLTFKLLTDKKIEFTPPKTMTRQLEEFIAWCLKPEPHERPTAQLLLNSDFIKLNK 617

HSP 2 Score: 51.9878 bits (123), Expect = 1.541e-6
Identity = 32/135 (23.70%), Postives = 72/135 (53.33%), Query Frame = 2 
Query:   86 LATKFDLNSDEIVLMFNNVILDDFHRIDFYNIR---FDEIVWFGTLSDIITECDILLEIHS-DMSG------------IAERIVVNKNENINFVRAILARFHRWIMKVPLYNHKMQPIKADKSVESYGLVEFPVI 442
            L+    ++ ++ VL+ +++IL+    I +Y I     ++++WFG ++D +   +I++ + S D SG            +  +++V  ++ I  +R  + + ++WI K+P +N   + +K D+ VE  GL+   +I
Sbjct:  123 LSKAVRVDKNDFVLICDDMILESDDWIKYYRIPNPVTEDVIWFGKIADYLKLNEIIIVMKSMDRSGGNSEPGSMFCIPVNIQLIVRLDQRIGEIRNHIGKIYKWIAKIPFWNFNKERLKDDQMVEESGLLNTSII 257
[Close]
BLAST of Mitogen-activated protein kinase kinase kinase 3 vs. Planmine SMEST
Match: SMESG000009509.1 (SMESG000009509.1)

HSP 1 Score: 250.751 bits (639), Expect = 3.811e-79
Identity = 122/126 (96.83%), Postives = 123/126 (97.62%), Query Frame = 2 
Query:   74 ILKTLATKFDLNSDEIVLMFNNVILDDFHRIDFYNIRFDEIVWFGTLSDIITECDILLEIHSDMSGIAERIVVNKNENINFVRAILARFHRWIMKVPLYNHKMQPIKADKSVESYGLVEFPVINII 451
            I KTLATKFDLNSDEIVLMFNNVI DDFHRIDFYNIRFDEIVWFGTLSDIITECDILLEIHSDMSGIAERIVVNKNENINFVRAILARFHRWIMKVPLYNHKMQPIK DKSVESYGLVEFPVINI+
Sbjct:   24 IKKTLATKFDLNSDEIVLMFNNVIFDDFHRIDFYNIRFDEIVWFGTLSDIITECDILLEIHSDMSGIAERIVVNKNENINFVRAILARFHRWIMKVPLYNHKMQPIKVDKSVESYGLVEFPVINIM 149

HSP 2 Score: 55.8398 bits (133), Expect = 5.675e-9
Identity = 40/164 (24.39%), Postives = 85/164 (51.83%), Query Frame = 2 
Query:  488 LKFRGFGKELYSDKE------QIDLVKTDLSKAVRVDKNDFVLICDDMILESDDWIKYYRIPNPVTEDVIWFGKIADYLKLNEIIIVMKSMDRSGGNSEPGSMFCIPVNIQLIVRLNQRIGEIRNHIGKIYKWIAKIPFWNFNKERLKDDQMVEESGLLNTSII 961
            +KF+G G  L+ DK+       +  +K  L+    ++ ++ VL+ +++I +    I +Y I     ++++WFG ++D +   +I++ + S D SG            +  +++V  N+ I  +R  + + ++WI K+P +N   + +K D+ VE  GL+   +I
Sbjct:    1 MKFKGIG--LHEDKDIKIPQPLVKNIKKTLATKFDLNSDEIVLMFNNVIFDDFHRIDFYNIR---FDEIVWFGTLSDIITECDILLEIHS-DMSG------------IAERIVVNKNENINFVRAILARFHRWIMKVPLYNHKMQPIKVDKSVESYGLVEFPVI 146

HSP 3 Score: 53.5286 bits (127), Expect = 3.770e-8
Identity = 25/27 (92.59%), Postives = 26/27 (96.30%), Query Frame = 1 
Query:    7 MKFKGIGLHEDKDIKIPQPLVKNIKNS 87
            MKFKGIGLHEDKDIKIPQPLVKNIK +
Sbjct:    1 MKFKGIGLHEDKDIKIPQPLVKNIKKT 27
The following BLAST results are available for this feature:
BLAST of Mitogen-activated protein kinase kinase kinase 3 vs. Ensembl Human
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Human e!99)
Total hits: 5
Match NameE-valueIdentityDescription
MAP3K37.233e-4338.61mitogen-activated protein kinase kinase kinase 3 [... [more]
MAP3K37.304e-4340.38mitogen-activated protein kinase kinase kinase 3 [... [more]
MAP3K37.465e-4338.61mitogen-activated protein kinase kinase kinase 3 [... [more]
MAP3K37.465e-4338.61mitogen-activated protein kinase kinase kinase 3 [... [more]
MAP3K39.483e-4338.61mitogen-activated protein kinase kinase kinase 3 [... [more]
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BLAST of Mitogen-activated protein kinase kinase kinase 3 vs. Ensembl Celegans
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99)
Total hits: 5
Match NameE-valueIdentityDescription
nsy-11.031e-3437.17Mitogen-activated protein kinase kinase kinase nsy... [more]
nsy-11.184e-3437.17Mitogen-activated protein kinase kinase kinase nsy... [more]
gck-11.641e-3434.02Germinal center kinase 1 [Source:UniProtKB/Swiss-... [more]
gck-14.971e-3433.94Germinal center kinase 1 [Source:UniProtKB/Swiss-... [more]
gck-15.234e-3433.94Germinal center kinase 1 [Source:UniProtKB/Swiss-... [more]
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BLAST of Mitogen-activated protein kinase kinase kinase 3 vs. Ensembl Fly
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99)
Total hits: 5
Match NameE-valueIdentityDescription
Mekk11.942e-3335.07gene:FBgn0024329 transcript:FBtr0331353[more]
Mekk12.099e-3335.07gene:FBgn0024329 transcript:FBtr0083684[more]
GckIII1.480e-3234.56gene:FBgn0266465 transcript:FBtr0083399[more]
hpo2.375e-3032.53gene:FBgn0261456 transcript:FBtr0331920[more]
hpo2.375e-3032.53gene:FBgn0261456 transcript:FBtr0086500[more]
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BLAST of Mitogen-activated protein kinase kinase kinase 3 vs. Ensembl Zebrafish
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99)
Total hits: 5
Match NameE-valueIdentityDescription
map3k31.077e-4238.93mitogen-activated protein kinase kinase kinase 3 [... [more]
map3k21.252e-4240.08mitogen-activated protein kinase kinase kinase 2 [... [more]
map3k21.276e-4240.08mitogen-activated protein kinase kinase kinase 2 [... [more]
map3k31.405e-4238.93mitogen-activated protein kinase kinase kinase 3 [... [more]
map3k31.578e-4238.93mitogen-activated protein kinase kinase kinase 3 [... [more]
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BLAST of Mitogen-activated protein kinase kinase kinase 3 vs. Ensembl Xenopus
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99)
Total hits: 5
Match NameE-valueIdentityDescription
samd81.463e-4642.42sterile alpha motif domain containing 8 [Source:Xe... [more]
samd82.108e-4642.42sterile alpha motif domain containing 8 [Source:Xe... [more]
MAP3K23.082e-4038.87mitogen-activated protein kinase kinase kinase 2 [... [more]
MAP3K24.754e-4038.87mitogen-activated protein kinase kinase kinase 2 [... [more]
dennd1a7.403e-4038.93DENN domain containing 1A [Source:Xenbase;Acc:XB-G... [more]
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BLAST of Mitogen-activated protein kinase kinase kinase 3 vs. Ensembl Mouse
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99)
Total hits: 5
Match NameE-valueIdentityDescription
Map3k31.595e-4240.38mitogen-activated protein kinase kinase kinase 3 [... [more]
Map3k23.712e-4139.69mitogen-activated protein kinase kinase kinase 2 [... [more]
Map3k193.315e-3733.96mitogen-activated protein kinase kinase kinase 19 ... [more]
Map3k191.939e-3534.34mitogen-activated protein kinase kinase kinase 19 ... [more]
Map3k193.092e-3534.34mitogen-activated protein kinase kinase kinase 19 ... [more]
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BLAST of Mitogen-activated protein kinase kinase kinase 3 vs. UniProt/SwissProt
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt)
Total hits: 5
Match NameE-valueIdentityDescription
sp|Q99759|M3K3_HUMAN3.474e-4238.61Mitogen-activated protein kinase kinase kinase 3 O... [more]
sp|Q61084|M3K3_MOUSE1.116e-4140.38Mitogen-activated protein kinase kinase kinase 3 O... [more]
sp|Q9Y2U5|M3K2_HUMAN7.060e-4039.69Mitogen-activated protein kinase kinase kinase 2 O... [more]
sp|Q01389|BCK1_YEAST1.670e-3836.67Serine/threonine-protein kinase BCK1/SLK1/SSP31 OS... [more]
sp|Q86IX1|DST1_DICDI1.841e-3838.06Serine/threonine-protein kinase dst1 OS=Dictyostel... [more]
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BLAST of Mitogen-activated protein kinase kinase kinase 3 vs. TrEMBL
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL)
Total hits: 5
Match NameE-valueIdentityDescription
A0A2T7Q0V71.553e-4540.00Uncharacterized protein OS=Pomacea canaliculata OX... [more]
A7S4G71.414e-4340.93Predicted protein (Fragment) OS=Nematostella vecte... [more]
F6XXK92.297e-4342.42Sterile alpha motif domain containing 8 OS=Xenopus... [more]
A0A2G9SHV32.769e-4340.74Mitogen-activated protein kinase kinase kinase 3 O... [more]
A0A0S7KX403.173e-4340.84M3K2 (Fragment) OS=Poeciliopsis prolifica OX=18813... [more]
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BLAST of Mitogen-activated protein kinase kinase kinase 3 vs. Ensembl Cavefish
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99)
Total hits: 5
Match NameE-valueIdentityDescription
map3k35.348e-4339.31mitogen-activated protein kinase kinase kinase 3 [... [more]
map3k35.348e-4339.31mitogen-activated protein kinase kinase kinase 3 [... [more]
map3k35.348e-4339.31mitogen-activated protein kinase kinase kinase 3 [... [more]
map3k27.097e-4139.31mitogen-activated protein kinase kinase kinase 2 [... [more]
map3k222.607e-3938.40mitogen-activated protein kinase kinase kinase 3-l... [more]
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BLAST of Mitogen-activated protein kinase kinase kinase 3 vs. Ensembl Sea Lamprey
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99)
Total hits: 5
Match NameE-valueIdentityDescription
map3k25.378e-4137.87mitogen-activated protein kinase kinase kinase 2 [... [more]
stk25a1.798e-3235.93serine/threonine kinase 25a [Source:ZFIN;Acc:ZDB-G... [more]
MAP4K31.381e-3033.58mitogen-activated protein kinase kinase kinase kin... [more]
map3k191.778e-2928.67mitogen-activated protein kinase kinase kinase 19 ... [more]
ENSPMAT00000002962.13.041e-2733.45pep scaffold:Pmarinus_7.0:GL476671:16080:33623:-1 ... [more]
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BLAST of Mitogen-activated protein kinase kinase kinase 3 vs. Ensembl Yeast
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46)
Total hits: 5
Match NameE-valueIdentityDescription
BCK12.405e-4036.67MAPKKK acting in the protein kinase C signaling pa... [more]
CDC153.186e-3333.86Protein kinase of the Mitotic Exit Network; locali... [more]
STE206.409e-3333.83Cdc42p-activated signal transducing kinase; involv... [more]
STE119.954e-3031.74Signal transducing MEK kinase; involved in pheromo... [more]
KIC11.370e-2933.84Protein kinase of the PAK/Ste20 family, required f... [more]
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BLAST of Mitogen-activated protein kinase kinase kinase 3 vs. Ensembl Nematostella
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46)
Total hits: 5
Match NameE-valueIdentityDescription
EDO414101.936e-4740.93Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7... [more]
EDO319341.927e-3435.23Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7... [more]
EDO478212.895e-3432.44Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7... [more]
EDO428459.383e-3434.09Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7... [more]
EDO361501.399e-3133.21Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7... [more]
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BLAST of Mitogen-activated protein kinase kinase kinase 3 vs. Ensembl Medaka
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99)
Total hits: 5
Match NameE-valueIdentityDescription
map3k31.550e-4441.29mitogen-activated protein kinase kinase kinase 3 [... [more]
map3k21.896e-4240.46mitogen-activated protein kinase kinase kinase 2 [... [more]
map3k228.231e-4139.16mitogen-activated protein kinase kinase kinase 3 [... [more]
map3k221.214e-4039.16mitogen-activated protein kinase kinase kinase 3 [... [more]
map3k221.214e-4039.16mitogen-activated protein kinase kinase kinase 3 [... [more]
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BLAST of Mitogen-activated protein kinase kinase kinase 3 vs. Planmine SMEST
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST)
Total hits: 5
Match NameE-valueIdentityDescription
SMESG000009500.11.346e-698.99SMESG000009500.1[more]
SMESG000009500.11.572e-698.99SMESG000009500.1[more]
SMESG000009500.11.134e-677.72SMESG000009500.1[more]
SMESG000009500.11.541e-677.72SMESG000009500.1[more]
SMESG000009509.13.811e-7996.83SMESG000009509.1[more]
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Sequences
The following sequences are available for this feature:

transcript sequence

>SMED30011710 ID=SMED30011710|Name=Mitogen-activated protein kinase kinase kinase 3|organism=Schmidtea mediterranea sexual|type=transcript|length=2283bp
TTCAATATGAAATTCAAGGGCATAGGATTGCATGAAGACAAGGATATTAA
AATTCCGCAACCTTTAGTAAAGAATATTAAAAACTCTTGCCACAAAGTTT
GATTTAAATTCTGATGAGATAGTTCTTATGTTTAATAATGTAATTCTCGA
TGATTTCCATCGAATTGACTTTTATAACATCCGGTTTGATGAAATAGTTT
GGTTTGGAACGTTATCGGATATCATCACTGAATGTGACATTCTGCTGGAA
ATTCATTCCGACATGAGTGGAATTGCCGAGAGAATTGTTGTAAATAAAAA
TGAAAACATCAATTTTGTGAGAGCAATTTTGGCTAGATTTCATAGATGGA
TAATGAAGGTTCCATTATATAATCATAAAATGCAGCCGATTAAAGCTGAT
AAATCTGTGGAAAGTTATGGCCTTGTGGAGTTCCCAGTTATAAACATTAT
ATCAAGAATTCCAACCCCATTCATCAAAGGACCAAAATTGAAATTTCGTG
GATTCGGTAAAGAATTGTATTCGGACAAAGAACAGATAGATCTAGTGAAG
ACGGACTTATCAAAGGCCGTGAGAGTAGATAAAAATGATTTTGTACTGAT
TTGTGATGATATGATCTTGGAATCAGATGATTGGATCAAGTACTACCGGA
TTCCAAATCCAGTAACTGAAGATGTCATTTGGTTTGGTAAAATAGCTGAC
TATCTAAAATTAAATGAAATTATTATTGTCATGAAATCTATGGATAGATC
GGGGGGTAACAGCGAGCCTGGCAGCATGTTTTGCATTCCAGTGAATATCC
AACTGATCGTAAGGCTGAATCAGCGCATTGGGGAAATAAGAAATCATATT
GGAAAAATTTATAAATGGATTGCGAAAATCCCTTTTTGGAATTTTAACAA
AGAAAGATTAAAAGATGATCAAATGGTAGAGGAATCTGGGTTGCTGAATA
CGTCGATAATTTATATGAGTACTCCGTCAGTGGTTCCTTGTTTGAATGAA
GGTTTAACGGGCGAAACTAGTGATCCAAAATCATTCGTGAAAGCATTAGG
TAGCCATATTATTAAATCGTCAGTGAGATCAGGGATGCGCTCATTATTTC
TGTCACACCTCCAATCTCTTCCACCAGATTCAAAAGATCGAGATCGATTA
CGTTCAATCATAGAAGATATCACTCCGATGTCATACAATGTCGCGTTGTC
ATCCATTTCGACCGATCAGTCACCAATGCTTGTCGTGGGCACTGAAAAGA
TTACAGTAAGCGATTGTAAAAAGGCAGTGGCGGACCGAGTCAAGCGATTG
CCAGAGGAAATCATACTGATCAAGAGCAACCAATGTCTCAAAGATGATGA
GACCATTTCCAACTATGAATATTCTCCTGATTCCTATTTTGCATTGAGAT
CAGGAATTTCATATTTCAGCCTGTCCAAATTGGAAAACATTGTGAATCAA
GACCCAGTGGGAGAAGGAGGATTTGGCAAAGTTTATCAATGTGAAGATCT
GGCAACAAACAAAGTAATGGCCGTAAAAGAAATAAAAATTCCAAAAAACA
AAAAACTTTCGGATGTCACTAGTGCAATAAAAGAAATTCTGACTTTCTCC
AAACTGGAATGCCATCAGCGAATCATTCAATATTTTGATTTCTTTCAGAA
AGATGAAAAGACATTCTGTATCACCATGGAATATATGGCCAATGGTTCAC
TTAGCTCATATTTAGAAATAAATGGCCCACTGGAAGAAAGAGAAATAGCT
CGAATTTCTACACAAGTGTTAGAAGGCCTGTTATATCTTCATAACAATCA
AATATTGCATAGAGATATAAAAGGTGGAAATATTTTACTTGATGACAAGT
TGAATGCAAAACTAGCCGATTTTGGTTTATCAAAATGCTCAGAAGAAATT
TCTGGTTGGGACTTTTATACAGGAATTCTACAATCGAATGTCGGTACACA
AAATTGGACAGCACCGGAAGTCTTGAATGATGAAGCGTATGGACTGAAGG
CTGACATCTGGTCATTTGGAGCAACAGTTGTCGAGATGGTTGTTGGTGAA
CGTCCATATGCAGATTATGAAAGTGTTCAATTGACATTTAAGCTTTTAAC
AGATAAAAAAATAGAGTTTACTCCACCAAAAACGATGACAAGACAGCTGG
AAGAATTCATCGCCTGGTGCTTGAAACCAGAACCCCATGAAAGACCGACA
GCACAATTACTTTTAAATTCGGATTTTATAAAACTTAACAAATAAAATTT
GGTTTTGATTTCATAATAAAAACTAATAATAAG
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protein sequence of SMED30011710-orf-1

>SMED30011710-orf-1 ID=SMED30011710-orf-1|Name=SMED30011710-orf-1|organism=Schmidtea mediterranea sexual|type=polypeptide|length=706bp
MFNNVILDDFHRIDFYNIRFDEIVWFGTLSDIITECDILLEIHSDMSGIA
ERIVVNKNENINFVRAILARFHRWIMKVPLYNHKMQPIKADKSVESYGLV
EFPVINIISRIPTPFIKGPKLKFRGFGKELYSDKEQIDLVKTDLSKAVRV
DKNDFVLICDDMILESDDWIKYYRIPNPVTEDVIWFGKIADYLKLNEIII
VMKSMDRSGGNSEPGSMFCIPVNIQLIVRLNQRIGEIRNHIGKIYKWIAK
IPFWNFNKERLKDDQMVEESGLLNTSIIYMSTPSVVPCLNEGLTGETSDP
KSFVKALGSHIIKSSVRSGMRSLFLSHLQSLPPDSKDRDRLRSIIEDITP
MSYNVALSSISTDQSPMLVVGTEKITVSDCKKAVADRVKRLPEEIILIKS
NQCLKDDETISNYEYSPDSYFALRSGISYFSLSKLENIVNQDPVGEGGFG
KVYQCEDLATNKVMAVKEIKIPKNKKLSDVTSAIKEILTFSKLECHQRII
QYFDFFQKDEKTFCITMEYMANGSLSSYLEINGPLEEREIARISTQVLEG
LLYLHNNQILHRDIKGGNILLDDKLNAKLADFGLSKCSEEISGWDFYTGI
LQSNVGTQNWTAPEVLNDEAYGLKADIWSFGATVVEMVVGERPYADYESV
QLTFKLLTDKKIEFTPPKTMTRQLEEFIAWCLKPEPHERPTAQLLLNSDF
IKLNK*
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Annotated Terms
The following terms have been associated with this transcript:
Vocabulary: Planarian Anatomy
TermDefinition
PLANA:0000026gut
PLANA:0000034epidermis
PLANA:0000070intestinal phagocyte
PLANA:0002056medial muscle cell
PLANA:0003116parenchymal cell
Vocabulary: INTERPRO
TermDefinition
IPR001245Ser-Thr/Tyr_kinase_cat_dom
IPR000719Prot_kinase_dom
IPR008271Ser/Thr_kinase_AS
IPR017441Protein_kinase_ATP_BS
IPR011009Kinase-like_dom_sf
IPR029071Ubiquitin-like_domsf
Vocabulary: molecular function
TermDefinition
GO:0004672protein kinase activity
GO:0005524ATP binding
GO:0016301kinase activity
Vocabulary: biological process
TermDefinition
GO:0006468protein phosphorylation
GO:0016310phosphorylation