dual serine/threonine and tyrosine protein kinase

Query:  592 VMHSSDILFEGIKVVVMPSIKQKAIEEIRAIYDSHISDLLPILIYAFEFNDLSSWDKTELEEIKLLAQDSPIFFVKVPPYEKYSRLPADYKFTKEELLAVLNPPISFAPNGRKVSNTNANDSGDMKLFGTLCQMNLISAV--NNGFFSLTRSPKLETIDLNDLKIDSDLITQFDSFFEKLTNYCHSCIQKYLVRVLTIITKFASDALKNLILQVYDLSYSSVITPKKVEFAKQQELLLYNSLISRSTEKHEEICSLIGEILNIMKQTLPDAAAVEIDLESFQDKMV-------SIKMYKSATNTVREYVASKVNSAIAEKLLQSMDVLRNTYVGTLERTVNSLGKFEEENINATEA-LKNILHFTYGLHIPIKTSSTFMSSLIEKMKQLISRLPWQPDPTLDANWVMRTSSDMLNSISEVKLTHEVINQITENLKQSHENFIISIKRLENRVEVRQNKHAEMQDRIKRLYTPKLARLYLEGMSLRDNVLFGVPKLNREIGRGQYGVVYACNTWGAYNQMAVKSVVPPDEKHWCDLAMEFFYCKQMSEHDRIATIHGSVVDYNYSYGSNPAILFIMDRMARDFYAALKQGLDWVTRLQVSLDVIEGIRFLHSQGLIHRDIKLKNVLLDYNNRGKLTDLGFCKPCAMLSGSLVGTPIHMAPELFNQEYNFSVDIYAFGILFWYVCSNKVKVPTNFDRFTNKESLFEAVKKGLRPERPPKIDQECWDLISRCWHQDPNKRPLPGEIEDQL 2802
             MH +  L + + VVV P    + +     +    ++D LP++ YA   ++LS  D+ EL+EI+      P+FF KVP            K   E    +++            S+T   +S    L+  L  +  +S+   N G      +P        D K  S L+ Q +     L+ + H  +Q  LV     +       L   I Q +D+     ITPK++E+ +++E  LY SL++ +  K EE+  +I E LN MK+ L D A    ++E F+D +V         +  K     ++E + S++N A+A KL+ S+D LR ++VGTLER + SL K ++ +++ T   LK IL+  Y + +   + S+    L E++KQ+I R+ W   P +   W  + + + + S+S  KL   + +Q    L  SHE F  S+++LE     R  K  ++  R+++ + P+LARL LE  SL+D +L   PKL +E+GRGQYGVVY C+ WG +   A+KSVVPPDEKHW DLA+EF Y + + +H+R+  +HGSV+DYNY  GS+ A+L IM+R+ RD Y  LK GL   TRLQ++LDV+EGIRFLHSQGL+HRDIKLKNVLLD  NR K+TDLGFCKP AM+SGS+VGTPIHMAPELF  +Y+ SVD+YAFGILFWY+CS  VK+P  F+R  +K+ L+  V++G RPER P  D+ECW L+  CW  DP KRPL G ++  L
Sbjct:  211 TMHHA--LLQEVDVVVAPC---QGLRPTVDVLGDLVNDFLPVITYALHKDELSERDEQELQEIRKYF-SFPVFFFKVP------------KLGSE----IID------------SSTRRMESERSPLYRQLIDLGYLSSSHWNCG------APG------QDTKAQSMLVEQSEKL-RHLSTFSHQVLQTRLVDAAKALNLVHCHCLDIFINQAFDMQRDLQITPKRLEYTRKKENELYESLMNIANRKQEEMKDMIVETLNTMKEELLDDAT---NME-FKDVIVPENGEPVGTREIKCCIRQIQELIISRLNQAVANKLISSVDYLRESFVGTLERCLQSLEKSQDVSVHITSNYLKQILNAAYHVEVTFHSGSSVTRMLWEQIKQIIQRITWVSPPAITLEWKRKVAQEAIESLSASKLAKSICSQFRTRLNSSHEAFAASLRQLEAGHSGRLEKTEDLWLRVRKDHAPRLARLSLESCSLQDVLLHRKPKLGQELGRGQYGVVYLCDNWGGHFPCALKSVVPPDEKHWNDLALEFHYMRSLPKHERLVDLHGSVIDYNYGGGSSIAVLLIMERLHRDLYTGLKAGLTLETRLQIALDVVEGIRFLHSQGLVHRDIKLKNVLLDKQNRAKITDLGFCKPEAMMSGSIVGTPIHMAPELFTGKYDNSVDVYAFGILFWYICSGSVKLPEAFERCASKDHLWNNVRRGARPERLPVFDEECWQLMEACWDGDPLKRPLLGIVQPML 906          

Query:  592 VMHSSDILFEGIKVVVMPSIKQKAIEEIRAIYDSHISDLLPILIYAFEFNDLSSWDKTELEEIKLLAQDSPIFFVKVPPYEKYSRLPADYKFTKEELLAVLNPPISFAPNGRKVSNTNANDSGDMKLFGTLCQMNLISAV--NNGFFSLTRSPKLETIDLNDLKIDSDLITQFDSFFEKLTNYCHSCIQKYLVRVLTIITKFASDALKNLILQVYDLSYSSVITPKKVEFAKQQELLLYNSLISRSTEKHEEICSLIGEILNIMKQTLPDAAAVEIDLESFQDKMV-------SIKMYKSATNTVREYVASKVNSAIAEKLLQSMDVLRNTYVGTLERTVNSLGKFEEENINATEA-LKNILHFTYGLHIPIKTSSTFMSSLIEKMKQLISRLPWQPDPTLDANWVMRTSSDMLNSISEVKLTHEVINQITENLKQSHENFIISIKRLENRVEVRQNKHAEMQDRIKRLYTPKLARLYLEGMSLRDNVLFGVPKLNREIGRGQYGVVYACNTWGAYNQMAVKSVVPPDEKHWCDLAMEFFYCKQMSEHDRIATIHGSVVDYNYSYGSNPAILFIMDRMARDFYAALKQGLDWVTRLQVSLDVIEGIRFLHSQGLIHRDIKLKNVLLDYNNRGKLTDLGFCKPCAMLSGSLVGTPIHMAPELFNQEYNFSVDIYAFGILFWYVCSNKVKVPTNFDRFTNKESLFEAVKKGLRPERPPKIDQECWDLISRCWHQDPNKRPLPGEIEDQL 2802
             MH +  L + + VVV P    + +     +    ++D LP++ YA   ++LS  D+ EL+EI+      P+FF KVP            K   E    +++            S+T   +S    L+  L  +  +S+   N G      +P        D K  S L+ Q +     L+ + H  +Q  LV     +       L   I Q +D+     ITPK++E+ +++E  LY SL++ +  K EE+  +I E LN MK+ L D A    ++E F+D +V         +  K     ++E + S++N A+A KL+ S+D LR ++VGTLER + SL K ++ +++ T   LK IL+  Y + +   + S+    L E++KQ+I R+ W   P +   W  + + + + S+S  KL   + +Q    L  SHE F  S+++LE     R  K  ++  R+++ + P+LARL LE  SL+D +L   PKL +E+GRGQYGVVY C+ WG +   A+KSVVPPDEKHW DLA+EF Y + + +H+R+  +HGSV+DYNY  GS+ A+L IM+R+ RD Y  LK GL   TRLQ++LDV+EGIRFLHSQGL+HRDIKLKNVLLD  NR K+TDLGFCKP AM+SGS+VGTPIHMAPELF                                              G RPER P  D+ECW L+  CW  DP KRPL G ++  L
Sbjct:  211 TMHHA--LLQEVDVVVAPC---QGLRPTVDVLGDLVNDFLPVITYALHKDELSERDEQELQEIRKYF-SFPVFFFKVP------------KLGSE----IID------------SSTRRMESERSPLYRQLIDLGYLSSSHWNCG------APG------QDTKAQSMLVEQSEKL-RHLSTFSHQVLQTRLVDAAKALNLVHCHCLDIFINQAFDMQRDLQITPKRLEYTRKKENELYESLMNIANRKQEEMKDMIVETLNTMKEELLDDAT---NME-FKDVIVPENGEPVGTREIKCCIRQIQELIISRLNQAVANKLISSVDYLRESFVGTLERCLQSLEKSQDVSVHITSNYLKQILNAAYHVEVTFHSGSSVTRMLWEQIKQIIQRITWVSPPAITLEWKRKVAQEAIESLSASKLAKSICSQFRTRLNSSHEAFAASLRQLEAGHSGRLEKTEDLWLRVRKDHAPRLARLSLESCSLQDVLLHRKPKLGQELGRGQYGVVYLCDNWGGHFPCALKSVVPPDEKHWNDLALEFHYMRSLPKHERLVDLHGSVIDYNYGGGSSIAVLLIMERLHRDLYTGLKAGLTLETRLQIALDVVEGIRFLHSQGLVHRDIKLKNVLLDKQNRAKITDLGFCKPEAMMSGSIVGTPIHMAPELFT---------------------------------------------GARPERLPVFDEECWQLMEACWDGDPLKRPLLGIVQPML 861          

Query: 1705 LIEKMKQLISRLPWQPDPTLDANWVMRTSSDMLNSISEVKLTHEVINQITENLKQSHENFIISIKRLENRVEVRQNKHAEMQDRIKRLYTPKLARLYLEGMSLRDNVLFGVPKLNREIGRGQYGVVYACNTWGAYNQMAVKSVVPPDEKHWCDLAMEFFYCK 2190
            L E++KQ+I R+ W   P +   W  + + + + S+S  KL   + +Q    L  SHE F  S+++LE     R  K  ++  R+++ + P+LARL LE  SL+D +L   PKL +E+GRGQYGVVY C+ WG +   A+KSVVPPDEKHW DLA+EF Y +
Sbjct:    2 LWEQIKQIIQRITWVSPPAITLEWKRKVAQEAIESLSASKLAKSICSQFRTRLNSSHEAFAASLRQLEAGHSGRLEKTEDLWLRVRKDHAPRLARLSLESCSLQDVLLHRKPKLGQELGRGQYGVVYLCDNWGGHFPCALKSVVPPDEKHWNDLALEFHYMR 163          

Query: 2056 IGRGQYGVVYACNTWGAYNQMAVKSVVPPDEKHWCDLAMEFFYCKQMSEHDRIATIHGSVVDYNYSYGSNPAILFIMDRMARDFYAAL-----------KQGLDWVTRLQVSLDVIEGIRFLHSQGLIHRDIKLKNVLLD-YNNRGKLTDLGFCK------PCAMLSGSLVGTPIHMAPELFNQ---EYNFSVDIYAFGILFWYVCSNKVKVPTNFDRFTNKESLFEAVKKGLRPERPPKIDQECWDLISRCWHQDPNKRPLPGE-IEDQLLLMKTKAQ 2826
            +G+G YG+VYA        ++A+K +   D ++   L  E    K +         H ++V Y  S+  N  I   M+++     +AL           +Q + + T+      ++EG+++LH   ++HRDIK  NVL++ Y+   K++D G  K      PC   + +  GT  +MAPE+ ++    Y  + DI++ G     + + K   P  ++    + ++F+     + PE P  +  E    I +C+  DP+KR    + + D+ L + +K +
Sbjct:  686 LGKGTYGIVYAGRDLSNQVRIAIKEIPERDSRYSQPLHEEIALHKHLK--------HKNIVQYLGSFSENGFIKIFMEQVPGGSLSALLRSKWGPLKDNEQTIGFYTK-----QILEGLKYLHDNQIVHRDIKGDNVLINTYSGVLKISDFGTSKRLAGINPC---TETFTGTLQYMAPEIIDKGPRGYGKAADIWSLGCTIIEMATGK---PPFYELGEPQAAMFKVGMFKVHPEIPESMSAEAKAFILKCFEPDPDKRACANDLLVDEFLKVSSKKK 945          

Query: 2050 REIGRGQYGVVYACNTWGAYNQMAVKSVVPPDEKHWCDLAMEFFYCKQMSEHDRIATIHGSVVDYNYSYGSNPAILFIMDRMARDFYAALKQGLDWVTRLQVSLDVIEGIRFLHSQGLIHRDIKLKNVLLDYNNRGKLTDLGFCKPCAMLSGSLVGT-----PIHMAPE---LFNQEYNFSVDIYAFGILFWYVCSNKVKVPTNFDRFTNKESL--FEAVKKGLRPERPPKIDQECWDLISRCWHQDPNKRPLPGEI 2790
            +EIG GQ+GVV+    W ++ Q+A+K++         D   E     ++S H ++  ++G  +     Y       F+ +    ++    K  L     L V  D+ EG+ +L   G IHRD+  +N L+      K++D G  +   +L    V +     PI  +P    LFN+ Y+   D+++FG+L W V +   K+P     F NK +L   EA+ +G R  RP       ++++  CWH+ P  RP   E+
Sbjct:  275 KEIGSGQFGVVH-LGEWRSHIQVAIKAINEGSMSE-EDFIEEAKVMMKLS-HSKLVQLYGVCIQRKPLY---IVTEFMENGCLLNYLRENKGKLRKEMLLSVCQDICEGMEYLERNGYIHRDLAARNCLVSSTCIVKISDFGMTR--YVLDDEYVSSFGAKFPIKWSPPEVFLFNK-YSSKSDVWSFGVLMWEVFTEG-KMP-----FENKSNLQVVEAISEGFRLYRPHLAPMSIYEVMYSCWHEKPEGRPTFAEL 516          

Query: 2044 LNREIGRGQYGVVYACNTWGAYNQMAVKSVVPPDEKHWCDLAMEFFYCKQMSEHDRIATIHGSVVD-------YNYSYGSNPAILFIMDRMARDFYAALKQGLDWVTRLQVSLDVIEGIRFLHSQGLIHRDIKLKNVLLDYNNRGKLTDLGFCKPCAMLS--GSLVGTPIHMAPELFN-QEYNFSVDIYAFGILFWYVCSNKVKVPTNFDRFTNKESLFEAVKKGLRPE--RPPKIDQECWDLISRCWHQDPNKRPLPGEIEDQLLLMKTK 2820
            + ++IG G  G V+  N  G+ + +AVK +    +     L  E    KQ    + +  I   +VD        +Y  G N   + +   +     AA+ Q            + ++ + FLH   ++HRDIK  NVLL  N   KLTD+GFC      S   ++VGTP  M+PE+ N ++YN+ VDI++ GI+   +   +      + R T  ++++   + G +PE  +  ++  E  + + +C   DP++R    E+     L K K
Sbjct:    1 MKKQIGVGASGTVFVANVAGSTDVVAVKRMAFKTQPKKEMLLTEIKVMKQYRHPNLVNYIESYLVDADDLWVVMDYLEGGNLTDVVVKTELDEGQIAAVLQ------------ECLKALHFLHRHSIVHRDIKSDNVLLGMNGEVKLTDMGFCAQIQPGSKRDTVVGTPYWMSPEILNKKQYNYKVDIWSLGIMALEMIDGE----PPYLRETPLKAIYLIAQNG-KPEIKQRDRLSSEFNNFLDKCLVVDPDQRADTTELLAHPFLKKAK 254          

Query: 2029 FGVPKLNREIGRGQYGVVYACNTWGAYNQMAVKSVVPPDEKHWCDLAMEFFYCKQMSEHDRIATIHGSVVD-------YNYSYGSNPAILFIMDRMARDFYAALKQGLDWVTRLQVSLDVIEGIRFLHSQGLIHRDIKLKNVLLDYNNRGKLTDLGFCKPCAMLS--GSLVGTPIHMAPELFN-QEYNFSVDIYAFGILFWYVCSNKVKVPTNFDRFTNKESLFEAVKKGLRPE--RPPKIDQECWDLISRCWHQDPNKRPLPGEIEDQLLLMKTK 2820
             G  ++ ++IG G  G V+  N  G+ + +AVK +    +     L  E    KQ    + +  I   +VD        +Y  G N   + +   +     AA+ Q            + ++ + FLH   ++HRDIK  NVLL  N   KLTD+GFC      S   ++VGTP  M+PE+ N ++YN+ VDI++ GI+   +   +      + R T  ++++   + G +PE  +  ++  E  + + +C   DP++R    E+     L K K
Sbjct:  153 LGKYEMKKQIGVGASGTVFVANVAGSTDVVAVKRMAFKTQPKKEMLLTEIKVMKQYRHPNLVNYIESYLVDADDLWVVMDYLEGGNLTDVVVKTELDEGQIAAVLQ------------ECLKALHFLHRHSIVHRDIKSDNVLLGMNGEVKLTDMGFCAQIQPGSKRDTVVGTPYWMSPEILNKKQYNYKVDIWSLGIMALEMIDGE----PPYLRETPLKAIYLIAQNG-KPEIKQRDRLSSEFNNFLDKCLVVDPDQRADTTELLAHPFLKKAK 411          

Query: 2044 LNREIGRGQYGVVYACNTWGAYNQMAVKSV--VPPDEKHWCDLAMEFFYCKQMSEHDRIATIHGSVVDYNYSYGSNPAILFI-------MDRMARDFYAALKQGLDWVTRLQVSLDVIEGIRFLHSQGLIHRDIKLKNVLLDYNNRGKLTDLGFCKPCAMLSGSLVGTPIH---MAPELF-NQEYNFSVDIYAFGILFWYVCSNKVKVP-TNFDRFTNKESLFEAVKKGLRPERPPKIDQECWDLISRCWHQDPNKRPLPGEIEDQL 2802
              ++IG G YG VY          +AVK +     DE+   D+ M+     Q+ +H  I   +G ++D        P +L +       ++ + RD     K  +    R+Q +     G+ +LH +  IHRDI  +N L+ +N   K+ D G C+  A+    L   P++   +APE++ N E  ++ D+YAFG++ W       + P T +  +T K+     V+ G R + P  + ++   L++ CW+ DP KRP   +++++L
Sbjct:  124 FKKQIGSGAYGTVYRGRLVKTNAIVAVKKLDTEGTDEEGLTDM-MKEARVMQLYDHPNIVKFYGYILD------DVPYLLVLEFCNGGSVEDLLRD-----KPEIKINRRVQYTYMAACGMDYLHKKNCIHRDIASRNCLI-HNGVVKMADFGMCRATAVYKVDL-SKPLNVRWLAPEVWTNGETRYNTDVYAFGVMIWEFFITPYQSPYTEWKGYTVKQK----VRGGYRMQPPEGMPKDVASLLAECWNHDPEKRPNAEKLKEKL 372          

Query: 2029 FGVPKLNREIGRGQYGVVYACNTWGAYNQMAVKSVVPPDEKHWCDLAMEFFYCKQMSEHDRIATIHGSVVD-------YNYSYGSNPAILFIMDRMARDFYAALKQGLDWVTRLQVSLDVIEGIRFLHSQGLIHRDIKLKNVLLDYNNRGKLTDLGFCKPCAMLSGS----LVGTPIHMAPELFN-QEYNFSVDIYAFGILFWYVCSNKVKVPTNFDRFTNKESLFEAVKKGLRPE--RPPKIDQECWDLISRCWHQDPNKRPLPGEIEDQLLLMKTK 2820
             G  ++ ++IG G  G V+  N  G+ + +AVK +    +     L  E    KQ    + +  I   +VD        +Y  G N   + +   +     AA+ Q            + ++ + FLH   ++HRDIK  NVLL  N   KLTD+GFC    +  GS    +VGTP  M+PE+ N ++YN+ VDI++ GI+   +   +      + R T  ++++   + G +PE  +  ++  E  + + +C   DP++R    E+     L K K
Sbjct:  325 LGKYEMKKQIGVGASGTVFVANVAGSTDVVAVKRMAFKTQPKKEMLLTEIKVMKQYRHPNLVNYIESYLVDADDLWVVMDYLEGGNLTDVVVKTELDEGQIAAVLQ------------ECLKALHFLHRHSIVHRDIKSDNVLLGMNGEVKLTDMGFC--AQIQPGSKRDTVVGTPYWMSPEILNKKQYNYKVDIWSLGIMALEMIDGE----PPYLRETPLKAIYLIAQNG-KPEIKQRDRLSSEFNNFLDKCLVVDPDQRADTTELLAHPFLKKAK 583          

Query: 2029 FGVPKLNREIGRGQYGVVYACNTWGAYNQMAVKSVVPPDEKHWCDLAMEFFYCKQMSEHDRIATIHGSVVD-------YNYSYGSNPAILFIMDRMARDFYAALKQGLDWVTRLQVSLDVIEGIRFLHSQGLIHRDIKLKNVLLDYNNRGKLTDLGFCKPCAMLSGS----LVGTPIHMAPELFN-QEYNFSVDIYAFGILFWYVCSNKVKVPTNFDRFTNKESLFEAVKKGLRPE--RPPKIDQECWDLISRCWHQDPNKRPLPGEIEDQLLLMKTK 2820
             G  ++ ++IG G  G V+  N  G+ + +AVK +    +     L  E    KQ    + +  I   +VD        +Y  G N   + +   +     AA+ Q            + ++ + FLH   ++HRDIK  NVLL  N   KLTD+GFC    +  GS    +VGTP  M+PE+ N ++YN+ VDI++ GI+   +   +      + R T  ++++   + G +PE  +  ++  E  + + +C   DP++R    E+     L K K
Sbjct:  328 LGKYEMKKQIGVGASGTVFVANVAGSTDVVAVKRMAFKTQPKKEMLLTEIKVMKQYRHPNLVNYIESYLVDADDLWVVMDYLEGGNLTDVVVKTELDEGQIAAVLQ------------ECLKALHFLHRHSIVHRDIKSDNVLLGMNGEVKLTDMGFC--AQIQPGSKRDTVVGTPYWMSPEILNKKQYNYKVDIWSLGIMALEMIDGEPP----YLRETPLKAIYLIAQNG-KPEIKQRDRLSSEFNNFLDKCLVVDPDQRADTTELLAHPFLKKAK 586          

Query: 2005 MSLRDNVLFGVPKLNREIGRGQYGVVYACNTWGAYNQ----MAVKSVVPPDEKHWCDLAMEFFYCKQMSEHDRIATIHGSVVDYNYSYGSNPAILFIMDRMARDFYAALKQGLDWVTR---LQVSLDVIEGIRFLHSQGLIHRDIKLKNVLLDYNNRGKLTDLGFC---KPCAMLSGSLVGTPIHMAPELFNQE--YNFSVDIYAFGILFWYVCSNKVKVPTNFDRFTNKESLFEAVKKGLRPERPPKIDQECWDLISRCWHQ 2757
            M L D+ L  V    R +G+G +G V+ C+      Q    + VK ++  + K    L  E  Y      H  I     S   ++++   N  + ++ +   RD    L  G   V +   +    D++ G+ +LH + +IHRDIK +N+LLD N+R K+ D G      P   L   + GTP++MAPE  + +   +F  D+++ G++ + +C  +       D+      L   V+  +RP    ++ +  +D +   W Q
Sbjct:    1 MELGDSKLRAV----RVLGQGTFGRVFLCHQNEVRGQPERKVCVKRIIVRNPKTELGLIKEEVYIISQLRHPHIVEFLRS---FSHAGTVNIVMEYVPNGTLRDVIQQLPSGTGGVNQERLMGYFRDMVVGLEYLHIRCVIHRDIKPENMLLDANDRVKIADFGIANVHAPSTQLQAGM-GTPMYMAPEAMSSQGKVDFKSDVWSLGLVLYELCLGRSPFAAFLDKNATPALLHTVVQALVRPRLDCQLIRRLYDPV---WAQ 252          

Query: 2044 LNREIGRGQYGVVYACNTWGAY-NQMAVKSVVPPDEKHWCDLAMEFFYCKQMSEHDRIATIHGSVVDYNYSYGSNPAILFIMDRMAR----DFY-AALKQGLDWVTRLQVSLDVIEGIRFLHSQGLIHRDIKLKNVLLDYNNRGKLTDLGFC---KPCAMLSGSLVGTPIH-MAPE-LFNQEYNFSVDIYAFGILFWYVCSNKVKVPTNFDRFTNKESLFEAVKKGLRPERPPKIDQECWDLISRCWHQDPNKRP 2775
            +  ++G GQYG VY    W  Y N +AVK++   D     D   E    K+M +H  +  + G            P    I + M+     DF  +A ++ LD V  L ++  +  G+ +L S+  IHRD+  +N L+  N   K+ D G     +     + +    PI   APE L   +++   D++AFG+L W + +  +      D  T+   ++  + KG R ERPP    E +DL+ +CW  D   RP
Sbjct:  391 MKHKLGGGQYGEVYEA-VWKRYGNTVAVKTLKE-DTMALKDFLEEAAIMKEM-KHPNLVQLIGVCT-------REPPFYIITEFMSHGNLLDFLRSAGRETLDAVALLYMATQIASGMSYLESRNYIHRDLAARNCLVGDNKLVKVADFGLARLMRDDTYTAHAGAKFPIKWTAPEGLAYNKFSTKSDVWAFGVLLWEIATYGMSPYPAID-LTD---VYHKLDKGYRMERPPGCPPEVYDLMRQCWQWDATDRP 631          

Query: 2044 LNREIGRGQYGVVYACNTWGAY-NQMAVKSVVPPDEKHWCDLAMEFFYCKQMSEHDRIATIHGSVVDYNYSYGSNPAILFIMDRMAR----DFY-AALKQGLDWVTRLQVSLDVIEGIRFLHSQGLIHRDIKLKNVLLDYNNRGKLTDLGFC---KPCAMLSGSLVGTPIH-MAPE-LFNQEYNFSVDIYAFGILFWYVCSNKVKVPTNFDRFTNKESLFEAVKKGLRPERPPKIDQECWDLISRCWHQDPNKRP 2775
            +  ++G GQYG VY    W  Y N +AVK++   D     D   E    K+M +H  +  + G            P    I + M+     DF  +A ++ LD V  L ++  +  G+ +L S+  IHRD+  +N L+  N   K+ D G     +     + +    PI   APE L   +++   D++AFG+L W + +  +      D  T+   ++  + KG R ERPP    E +DL+ +CW  D   RP
Sbjct:  373 MKHKLGGGQYGEVYEA-VWKRYGNTVAVKTLKE-DTMALKDFLEEAAIMKEM-KHPNLVQLIGVCT-------REPPFYIITEFMSHGNLLDFLRSAGRETLDAVALLYMATQIASGMSYLESRNYIHRDLAARNCLVGDNKLVKVADFGLARLMRDDTYTAHAGAKFPIKWTAPEGLAYNKFSTKSDVWAFGVLLWEIATYGMSPYPAID-LTD---VYHKLDKGYRMERPPGCPPEVYDLMRQCWQWDATDRP 613          

Query: 2044 LNREIGRGQYGVVYACNTWGAY-NQMAVKSVVPPDEKHWCDLAMEFFYCKQMSEHDRIATIHGSVVDYNYSYGSNPAILFIMDRMAR----DFY-AALKQGLDWVTRLQVSLDVIEGIRFLHSQGLIHRDIKLKNVLLDYNNRGKLTDLGFC---KPCAMLSGSLVGTPIH-MAPE-LFNQEYNFSVDIYAFGILFWYVCSNKVKVPTNFDRFTNKESLFEAVKKGLRPERPPKIDQECWDLISRCWHQDPNKRP 2775
            +  ++G GQYG VY    W  Y N +AVK++   D     D   E    K+M +H  +  + G            P    I + M+     DF  +A ++ LD V  L ++  +  G+ +L S+  IHRD+  +N L+  N   K+ D G     +     + +    PI   APE L   +++   D++AFG+L W + +  +      D  T+   ++  + KG R ERPP    E +DL+ +CW  D   RP
Sbjct:  373 MKHKLGGGQYGEVYEA-VWKRYGNTVAVKTLKE-DTMALKDFLEEAAIMKEM-KHPNLVQLIGVCT-------REPPFYIITEFMSHGNLLDFLRSAGRETLDAVALLYMATQIASGMSYLESRNYIHRDLAARNCLVGDNKLVKVADFGLARLMRDDTYTAHAGAKFPIKWTAPEGLAYNKFSTKSDVWAFGVLLWEIATYGMSPYPAID-LTD---VYHKLDKGYRMERPPGCPPEVYDLMRQCWQWDATDRP 613          

Query: 2044 LNREIGRGQYGVVYACNTWGAY-NQMAVKSVVPPDEKHWCDLAMEFFYCKQMSEHDRIATIHGSVVDYNYSYGSNPAILFIMDRMAR----DFY-AALKQGLDWVTRLQVSLDVIEGIRFLHSQGLIHRDIKLKNVLLDYNNRGKLTDLGFC---KPCAMLSGSLVGTPIH-MAPE-LFNQEYNFSVDIYAFGILFWYVCSNKVKVPTNFDRFTNKESLFEAVKKGLRPERPPKIDQECWDLISRCWHQDPNKRP 2775
            +  ++G GQYG VY    W  Y N +AVK++   D     D   E    K+M +H  +  + G            P    I + M+     DF  +A ++ LD V  L ++  +  G+ +L S+  IHRD+  +N L+  N   K+ D G     +     + +    PI   APE L   +++   D++AFG+L W + +  +      D  T+   ++  + KG R ERPP    E +DL+ +CW  D   RP
Sbjct:  391 MKHKLGGGQYGEVYEA-VWKRYGNTVAVKTLKE-DTMALKDFLEEAAIMKEM-KHPNLVQLIGVCT-------REPPFYIITEFMSHGNLLDFLRSAGRETLDAVALLYMATQIASGMSYLESRNYIHRDLAARNCLVGDNKLVKVADFGLARLMRDDTYTAHAGAKFPIKWTAPEGLAYNKFSTKSDVWAFGVLLWEIATYGMSPYPAID-LTD---VYHKLDKGYRMERPPGCPPEVYDLMRQCWQWDATDRP 631          

Query:  613 LFEGIKVVVMPSIKQKAIEEIRAIYDSHISDLLPILIYAFEFNDLSSWDKTELEEIKLLAQDSP--IFFVKVPPYEKYSRLPADYKFTKEELLAVLNPPISFAPNGRKVSNTNANDSGDMKLFGTLCQMNLISAVNNGFFSLTRSPKLETIDLNDLKIDSDLITQFDSFFEKLTNYCHSCIQKYLVRVLTIITKFASDALKNLILQVYDLSYSSVITPKKVEFAKQQELLLYNSLISRSTEKHEEICSLIGEILNIMK-QTLPDAAAVEID--LESFQDKMVSIKMYKSATNTVREYVASKVNSAIAEKLLQSMDVLRNTYVGTLERTVNSLGKFEEENIN---ATEALKNILHFTYGLHIPIKTSSTFMSSLIEKMKQLISRLPWQPDPTLDANWVMRTSSDMLNSISEVKLTHEVINQITENLKQSHENFIISIKRLENRVEVRQNKHAEMQDRIKRLYTPKLARLYLEGMSLRDNVLFGVPKLNREIGRGQYGVVYACNTWGAYNQMAVKSVVPPDEKHWCDLAMEFFYCKQMSEHDRIATIHGSVVDYNYSYGSNPAILFIMDRMARDFYAALKQGLDWVTRLQVSLDVIEGIRFLHSQGLIHRDIKLKNVLLDYNNRGKLTDLGFCKPCAMLSGSLVGTPIHMAPELFNQEYNFSVDIYAFGILFWYVCSNKVKVPTNFDRFTNKESLFEAVKKGLRPERPPKIDQECWDLISRCWHQDPNKRPLPGEIEDQL 2802
            L + +K++V+P    + +EE  A+ D     +LPI++YA     LS+    +LE+++ L +  P  + F++V                                         ++  G   LF  L  + LISA          +P  ++      ++   L    +     L  +    +Q   V   T++       L   I+Q +D+     ITP+++E+ +++E  L+ SL++ +  K EE+  +I E L+ MK Q L DA  ++    + S   + VS K  K   + +++ + +++N A+A KL  S+D LR ++VGTLER + SL K   E+      +  LK IL+  Y + +   + S+      E++KQ+I R+ W   P + A W  + + D + S+S  KL   + +Q    L  SHE F  S+++LE     R  +  ++  R+++ + P+LARL LE  SLRD +L G PKL RE+GRGQYGVVY C++W   +  A+KSVVPPD+KHW DLA+EF Y + + +H+R+  +HGSV+D++YS GS+ A+L IM+R+ RD Y  LK GL    RL ++LDV+EGIRFLHSQGL+HRDIKLKNVLLD  NR K+TDLGFCKP AM+SGS+VGTPIHMAPELF  +Y+ SVD+YAFGILFWY+CS  VK+P  F++  +K+ L+  VKKG RPER P  D+ECW L+  CW+ DP++RPL G ++  L
Sbjct:  184 LLQEVKIMVLPCRNVQPLEE--ALEDCK-RGILPIVLYAVSRESLSA---QQLEDLQTLRESLPFPVCFIRV-----------------------------------------SDGGGGGALFTQLASLQLISASAGN--CACGAPAAQSAG----RMQGVLCDSLERLQRVLVPFTRQVLQNQQVEAATLLNTIHCRCLDLFIIQAFDMQRDLQITPRRLEYTREKEGELFCSLMAIANRKQEEMKEMIVETLSSMKEQLLEDAQNLDFTDIIMSSNGEPVSSKDIKVCISQIQDLIVNRLNQAVANKLTNSVDYLRESFVGTLERCLGSLEKSTPESCAHNVTSNHLKQILNAAYHVEVTFHSGSSVTRLFWEQIKQIIHRITWVNPPAITAEWKRKVAQDAIESLSAAKLAKSICSQFRTRLNSSHEAFAASLRQLEEGHTGRLERTEDLWLRVRKDHAPRLARLSLESRSLRDILLHGKPKLGRELGRGQYGVVYLCDSWAGRHPCALKSVVPPDDKHWNDLALEFHYTRSLPKHERLVNLHGSVIDHSYSGGSSIAVLLIMERLHRDLYTGLKAGLSLKERLLIALDVVEGIRFLHSQGLLHRDIKLKNVLLDKQNRAKITDLGFCKPEAMMSGSIVGTPIHMAPELFTGKYDNSVDVYAFGILFWYLCSGSVKLPEAFEKCASKDQLWTNVKKGCRPERLPVFDEECWQLMEACWNGDPSQRPLLGIVQPGL 868          

Query:  613 LFEGIKVVVMPSIKQKAIEEIRAIYDSHISDLLPILIYAFEFNDLSSWDKTELEEIKLLAQDSP--IFFVKVPPYEKYSRLPADYKFTKEELLAVLNPPISFAPNGRKVSNTNANDSGDMKLFGTLCQMNLISAVNNGFFSLTRSPKLETIDLNDLKIDSDLITQFDSFFEKLTNYCHSCIQKYLVRVLTIITKFASDALKNLILQVYDLSYSSVITPKKVEFAKQQELLLYNSLISRSTEKHEEICSLIGEILNIMK-QTLPDAAAVEID--LESFQDKMVSIKMYKSATNTVREYVASKVNSAIAEKLLQSMDVLRNTYVGTLERTVNSLGKFEEENINATEALKNILHFTYGLHIPIKTSSTFMSSLIEKMKQLISRLPWQPDPTLDANWVMRTSSDMLNSISEVKLTHEVINQITENLKQSHENFIISIKRLENRVEVRQNKHAEMQDRIKRLYTPKLARLYLEGMSLRDNVLFGVPKLNREIGRGQYGVVYACNTWGAYNQMAVKSVVPPDEKHWCDLAMEFFYCKQMSEHDRIATIHGSVVDYNYSYGSNPAILFIMDRMARDFYAALKQGLDWVTRLQVSLDVIEGIRFLHSQGLIHRDIKLKNVLLDYNNRGKLTDLGFCKPCAMLSGSLVGTPIHMAPELFNQEYNFSVDIYAFGILFWYVCSNKVKVPTNFDRFTNKESLFEAVKKGLRPERPPKIDQECWDLISRCWHQDPNKRPLPGEIEDQL 2802
            L + +K++V+P    + +EE  A+ D     +LPI++YA     LS+    +LE+++ L +  P  + F++V                                         ++  G   LF  L  + LISA          +P  ++      ++   L    +     L  +    +Q   V   T++       L   I+Q +D+     ITP+++E+ +++E  L+ SL++ +  K EE+  +I E L+ MK Q L DA  ++    + S   + VS K  K   + +++ + +++N A+A KL  S+D LR ++VGTLER + SL K   E+           H     H                +KQ+I R+ W   P + A W  + + D + S+S  KL   + +Q    L  SHE F  S+++LE     R  +  ++  R+++ + P+LARL LE  SLRD +L G PKL RE+GRGQYGVVY C++W   +  A+KSVVPPD+KHW DLA+EF Y + + +H+R+  +HGSV+D++YS GS+ A+L IM+R+ RD Y  LK GL    RL ++LDV+EGIRFLHSQGL+HRDIKLKNVLLD  NR K+TDLGFCKP AM+SGS+VGTPIHMAPELF  +Y+ SVD+YAFGILFWY+CS  VK+P  F++  +K+ L+  VKKG RPER P  D+ECW L+  CW+ DP++RPL G ++  L
Sbjct:  184 LLQEVKIMVLPCRNVQPLEE--ALEDCK-RGILPIVLYAVSRESLSA---QQLEDLQTLRESLPFPVCFIRV-----------------------------------------SDGGGGGALFTQLASLQLISASAGN--CACGAPAAQSAG----RMQGVLCDSLERLQRVLVPFTRQVLQNQQVEAATLLNTIHCRCLDLFIIQAFDMQRDLQITPRRLEYTREKEGELFCSLMAIANRKQEEMKEMIVETLSSMKEQLLEDAQNLDFTDIIMSSNGEPVSSKDIKVCISQIQDLIVNRLNQAVANKLTNSVDYLRESFVGTLERCLGSLEKSTPESCA---------HNVTSNH----------------LKQIIHRITWVNPPAITAEWKRKVAQDAIESLSAAKLAKSICSQFRTRLNSSHEAFAASLRQLEEGHTGRLERTEDLWLRVRKDHAPRLARLSLESRSLRDILLHGKPKLGRELGRGQYGVVYLCDSWAGRHPCALKSVVPPDDKHWNDLALEFHYTRSLPKHERLVNLHGSVIDHSYSGGSSIAVLLIMERLHRDLYTGLKAGLSLKERLLIALDVVEGIRFLHSQGLLHRDIKLKNVLLDKQNRAKITDLGFCKPEAMMSGSIVGTPIHMAPELFTGKYDNSVDVYAFGILFWYLCSGSVKLPEAFEKCASKDQLWTNVKKGCRPERLPVFDEECWQLMEACWNGDPSQRPLLGIVQPGL 840          

Query: 2050 REIGRGQYGVVYACNTWGAYNQMAVKSVVPPDEKHWCDLAMEFFYCKQMSEHDRIAT-------IHGSVVDYNYSYGSNPAILFIMDRMARD-FYAALKQGL---DWVTRLQVSLDVIEGIRFLHSQGLIHRDIKLKNVLLDYNNRGKLTDLGFCKPCAMLSG---SLVGT--PIHMAPE--LFNQEYNFSVDIYAFGILFWYVCSNKVKVPTNFDRFTNKESLFEAVKKGLRPERPPKIDQECWDLISRCWHQDPNKRP----LPGEIEDQLLLMK 2814
            RE+G GQ+GVV     W   + +A+K V                    MSE D I          HG++V           I  + + +A       L++GL     +  L++  DV EG+++L +   IHRD+  +N L+D N   K+TD G  +   +L     S VG+  P+  +P   L   +++   DI+AFG+L W + + + ++P  +DR+ N E + E +  G R  RP   ++  + +++ CWH+ P++RP    L G I+D L  M+
Sbjct:  385 RELGNGQFGVV-KYGKWQGRHDVAIKMVKE----------------GSMSEDDFIEEAKVMMKLCHGNLVQLYGVCTKQRPIYIVTEYLANGCLLNYLQEGLLNPTSIALLEMCKDVSEGMKYLEANQFIHRDLAARNCLVDSNGTIKVTDFGLSR--YVLDDEYTSSVGSKFPVRWSPPEVLLYCKFSSKSDIWAFGVLMWEIYT-QGRMP--YDRWNNTE-IVEKISAGHRLYRPQMANENVFAIMNSCWHERPDERPTFQELVGVIKDLLFSMQ 638          

Query: 2251 SYGSNPAILFIMDRMARD---FYAALKQGLDWVTRLQVSLDVIEGIRFLHSQGLIHRDIKLKNVLLDYNNRGKLTDLGFCKPCAM---LSGSLVGTPIHMAPE-LFNQEYNFSVDIYAFGILFWYVCSNKVKVPTNFDRFTNKESLFEAVKKGLRPERPPKIDQECWDLISRCWHQDPNKR 2772
            ++ S   + F+M+ +      F+   K   D       + ++I G+++LHS+G+++RD+KL NV+LD +   K+ D G CK   +    + +  GTP ++APE L  Q+Y+FSVD ++FG+L + +     + P   D   +++ LF++++  + P  P  I +E  DL+ + + +DP +R
Sbjct:  425 TFQSKEHLFFVMEYLNGGDLMFHIQDKGRFDLYRATFYAAEIICGLQYLHSKGIVYRDLKLDNVMLDKDGHIKIADFGMCKENMIGENRATTFCGTPDYIAPEILLGQKYSFSVDWWSFGVLLYEMLIG--QSPFQGD---DEDELFDSIRMDV-PHYPRWITKEAKDLLEKLFERDPTRR 599          

Query: 2251 SYGSNPAILFIMDRMARD---FYAALKQGLDWVTRLQVSLDVIEGIRFLHSQGLIHRDIKLKNVLLDYNNRGKLTDLGFCKPCAM---LSGSLVGTPIHMAPE-LFNQEYNFSVDIYAFGILFWYVCSNKVKVPTNFDRFTNKESLFEAVKKGLRPERPPKIDQECWDLISRCWHQDPNKR 2772
            ++ S   + F+M+ +      F+   K   D       + ++I G+++LHS+G+++RD+KL NV+LD +   K+ D G CK   +    + +  GTP ++APE L  Q+Y+FSVD ++FG+L + +     + P   D   +++ LF++++  + P  P  I +E  DL+ + + +DP +R
Sbjct:  410 TFQSKEHLFFVMEYLNGGDLMFHIQDKGRFDLYRATFYAAEIICGLQYLHSKGIVYRDLKLDNVMLDKDGHIKIADFGMCKENMIGENRATTFCGTPDYIAPEILLGQKYSFSVDWWSFGVLLYEMLIG--QSPFQGD---DEDELFDSIRMDV-PHYPRWITKEAKDLLEKLFERDPTRR 584          

Query:  505 NKQDCINEEVLIDNAAKSDDEAFENSYVDVMHSSDILFEGIKVVVMPSIKQKAIEEIRAIYDSHISDLLPILIYAFEFNDLSSWDKTELEEIKLLAQDSPIFFVKVPPYEKYSRLPADYKFTKEELLAVLNPPISFAPNGRKVSNTNANDSGDMKLFGTLCQMNLISAVNNGFFSLTRSPKLETIDLNDLKIDSDLITQFDSFFEKLTNYCHSCIQKYLVRVLTIITKFASDALKNLILQVYDLSYSSVITPKKVEFAKQQELLLYNSLISRSTEKHEEICSLIGEILNIMK-QTLPDAAAVEI-DLESFQD-KMVSIKMYKSATNTVREYVASKVNSAIAEKLLQSMDVLRNTYVGTLERTVNSLGKFEEENIN--ATEALKNILHFTYGLHIPIKTSSTFMSSLIEKMKQLISRLPWQPDPTLDANWVMRTSSDMLNSISEVKLTHEVINQITENLKQSHENFIISIKRLENRVEVRQNKHAEMQDRIKRLYTPKLARLYLEGMSLRDNVLFGVPKLNREIGRGQYGVVYACNTWGAYNQMAVKSVVPPDEKHWCDLAMEFFYCKQMSEHDRIATIHGSVVDYNYSYGSNPAILFIMDRMARDFYAALKQGLDWVTRLQVSLDVIEGIRFLHSQGLIHRDIKLKNVLLDYNNRGKLTDLGFCKPCAMLSGSLVGTPIHMAPELFNQEYNFSVDIYAFGILFWYVCSNKVKVPTNFDRFTNKESLFEAVKKGLRPERPPKIDQECWDLISRCWHQDPNKRPLPGEIEDQL 2802
             K D I EE L D     +D A   + ++V     +L + + +VV P    +A+      Y  H+     I++YA     LS  D+ EL EIK      P+FF++        RL    +  +  L   L   + F   G  + N  A  SG                        + +P +             L+ QF+    +L+ +    +Q +LV    ++    S  L   I + +D+     ITPK++E+ +Q+E  LY SL+  S  K EE+  +I E LN M+ Q L DAA ++  D+   Q+ + VS++  K     ++E + S++N A+  KL+ S+D LR ++VGTLER + SL K ++E+ +   +  LK IL+  Y + +   + ST    + E++ Q+I R+ W   PT+   W  R + D + S+S  KL   + +Q  + LK SHE F  S+K+LE     R  K  ++  R+++ + P+LARL LE  SL+D +L G P++ RE+GRGQYGVVY C++WG +   A+KSVVPPDEKHW DLA+EF Y + + +H+R+  +HGSV+DY+Y  GS+ A+L I +R+ RD Y  LK GL   TRLQ++LDV+EGIRFLH+QGL+HRDIKLKNVLLD  +R K+TDLGFCKP AM+SGS+VGTPIHMAPELF+ +Y+ SVD+YAFGILFWY+CS  VK+P  F++  +K+ L+  V+KG RPER    D+ECW L+  CW+ DP++RPL G ++  L
Sbjct:  101 GKWDTIPEEDL-DVPEDEEDPAHRLAELEVTLPHQLL-QDVDIVVSPCRSSQAVSMTLEDYVDHVQS---IVVYAVCEERLSQQDEEELTEIKE-KYKLPVFFIRTSSTR--DRLIGGSEGVRSALYEQLME-LGFLKRG--LCNCGAAGSG------------------------STAPSM-------------LVEQFEKL-RQLSTFSRQVLQMHLVDAAIVLNMVHSRCLDLFINKAFDMHRDLQITPKRLEYTRQKENELYESLMRISDRKQEELKDMIVETLNSMREQLLEDAANMQFKDIAIPQNGEPVSVQEVKCCIFQIKELIISRLNQAVVNKLISSVDYLRESFVGTLERCLRSLEKSQQESSSHVTSNHLKQILNAAYHVEVTFNSGSTVTRMVWEQIVQIIQRITWVSPPTITPEWKRRVAQDAIESLSASKLAKSICSQFCKRLKSSHEAFAASLKQLEVGHSGRLEKTNDLWLRVRKDHAPRLARLSLESRSLQDVLLHGKPRIGRELGRGQYGVVYLCDSWGGHFPCALKSVVPPDEKHWNDLALEFHYMRSLPKHERLVDLHGSVIDYSYGGGSSIAVLLITERLHRDLYVGLKTGLSLETRLQIALDVVEGIRFLHNQGLVHRDIKLKNVLLDKKHRAKITDLGFCKPEAMMSGSIVGTPIHMAPELFSGKYDNSVDVYAFGILFWYICSGSVKLPEAFEKCASKDHLWNNVRKGARPERLAIFDEECWKLMEACWNGDPSQRPLMGIVQPML 822          

Query:  505 NKQDCINEEVLIDNAAKSDDEAFENSYVDVMHSSDILFEGIKVVVMPSIKQKAIEEIRAIYDSHISDLLPILIYAFEFNDLSSWDKTELEEIKLLAQDSPIFFVKVPPYEKYSRLPADYKFTKEELLAVLNPPISFAPNGRKVSNTNANDSGDMKLFGTLCQMNLISAVNNGFFSLTRSPKLETIDLNDLKIDSDLITQFDSFFEKLTNYCHSCIQKYLVRVLTIITKFASDALKNLILQVYDLSYSSVITPKKVEFAKQQELLLYNSLISRSTEKHEEICSLIGEILNIMK-QTLPDAAAVEI-DLESFQD-KMVSIKMYKSATNTVREYVASKVNSAIAEKLLQSMDVLRNTYVGTLERTVNSLGKFEEENIN--ATEALKNILHFTYGLHIPIKTSSTFMSSLIEKMKQLISRLPWQPDPTLDANWVMRTSSDMLNSISEVKLTHEVINQITENLKQSHENFIISIKRLENRVEVRQNKHAEMQDRIKRLYTPKLARLYLEGMSLRDNVLFGVPKLNREIGRGQYGVVYACNTWGAYNQMAVKSVVPPDEKHWCDLAMEFFYCKQMSEHDRIATIHGSVVDYNYSYGSNPAILFIMDRMARDFYAALKQGLDWVTRLQVSLDVIEGIRFLHSQGLIHRDIKLKNVLLDYNNRGKLTDLGFCKPCAMLSGSLVGTPIHMAPELFNQEYNFSVDIYAFGILFWYVCSNKVKVPTNFDRFTNKESLFEAVKKGLRPERPPKIDQECWDLISRCWHQDPNKRPLPGEIEDQL 2802
             K D I EE L D     +D A   + ++V     +L + + +VV P    +A+      Y  H+     I++YA     LS  D+ EL EIK      P+FF++        RL    +  +  L   L   + F   G  + N  A  SG                        + +P +             L+ QF+    +L+ +    +Q +LV    ++    S  L   I + +D+     ITPK++E+ +Q+E  LY SL+  S  K EE+  +I E LN M+ Q L DAA ++  D+   Q+ + VS++  K     ++E + S++N A+  KL+ S+D LR ++VGTLER + SL K ++E+ +   +  LK IL+  Y + +   + ST    + E++ Q+I R+ W   PT+   W  R + D + S+S  KL   + +Q  + LK SHE F  S+K+LE     R  K  ++  R+++ + P+LARL LE  SL+D +L G P++ RE+GRGQYGVVY C++WG +   A+KSVVPPDEKHW DLA+EF Y + + +H+R+  +HGSV+DY+Y  GS+ A+L I +R+ RD Y  LK GL   TRLQ++LDV+EGIRFLH+QGL+HRDIKLKNVLLD  +R K+TDLGFCKP AM+SGS+VGTPIHMAPELF+ +Y+ SVD+YAFGILFWY+CS  VK+P  F++  +K+ L+  V+KG RPER    D+ECW L+  CW+ DP++RPL G ++  L
Sbjct:   97 GKWDTIPEEDL-DVPEDEEDPAHRLAELEVTLPHQLL-QDVDIVVSPCRSSQAVSMTLEDYVDHVQS---IVVYAVCEERLSQQDEEELTEIKE-KYKLPVFFIRTSSTR--DRLIGGSEGVRSALYEQLME-LGFLKRG--LCNCGAAGSG------------------------STAPSM-------------LVEQFEKL-RQLSTFSRQVLQMHLVDAAIVLNMVHSRCLDLFINKAFDMHRDLQITPKRLEYTRQKENELYESLMRISDRKQEELKDMIVETLNSMREQLLEDAANMQFKDIAIPQNGEPVSVQEVKCCIFQIKELIISRLNQAVVNKLISSVDYLRESFVGTLERCLRSLEKSQQESSSHVTSNHLKQILNAAYHVEVTFNSGSTVTRMVWEQIVQIIQRITWVSPPTITPEWKRRVAQDAIESLSASKLAKSICSQFCKRLKSSHEAFAASLKQLEVGHSGRLEKTNDLWLRVRKDHAPRLARLSLESRSLQDVLLHGKPRIGRELGRGQYGVVYLCDSWGGHFPCALKSVVPPDEKHWNDLALEFHYMRSLPKHERLVDLHGSVIDYSYGGGSSIAVLLITERLHRDLYVGLKTGLSLETRLQIALDVVEGIRFLHNQGLVHRDIKLKNVLLDKKHRAKITDLGFCKPEAMMSGSIVGTPIHMAPELFSGKYDNSVDVYAFGILFWYICSGSVKLPEAFEKCASKDHLWNNVRKGARPERLAIFDEECWKLMEACWNGDPSQRPLMGIVQPML 818          

Query:  505 NKQDCINEEVLIDNAAKSDDEAFENSYVDVMHSSDILFEGIKVVVMPSIKQKAIEEIRAIYDSHISDLLPILIYAFEFNDLSSWDKTELEEIKLLAQDSPIFFVKVPPYEKYSRLPADYKFTKEELLAVLNPPISFAPNGRKVSNTNANDSGDMKLFGTLCQMNLISAVNNGFFSLTRSPKLETIDLNDLKIDSDLITQFDSFFEKLTNYCHSCIQKYLVRVLTIITKFASDALKNLILQVYDLSYSSVITPKKVEFAKQQELLLYNSLISRSTEKHEEICSLIGEILNIMK-QTLPDAAAVEI-DLESFQD-KMVSIKMYKSATNTVREYVASKVNSAIAEKLLQSMDVLRNTYVGTLERTVNSLGKFEEENIN--ATEALKNILHFTYGLHIPIKTSSTFMSSLIEKMKQLISRLPWQPDPTLDANWVMRTSSDMLNSISEVKLTHEVINQITENLKQSHENFIISIKRLENRVEVRQNKHAEMQDRIKRLYTPKLARLYLEGMSLRDNVLFGVPKLNREIGRGQYGVVYACNTWGAYNQMAVKSVVPPDEKHWCDLAMEFFYCKQMSEHDRIATIHGSVVDYNYSYGSNPAILFIMDRMARDFYAALKQGLDWVTRLQVSLDVIEGIRFLHSQGLIHRDIKLKNVLLDYNNRGKLTDLGFCKPCAMLSGSLVGTPIHMAPELFNQEYNFSVDIYAFGILFWYVCSNKVKVPTNFDRFTNKESLFEAVKKGLRPERPPKIDQECWDLISRCWHQDPNKRPLPGEIEDQL 2802
             K D I EE L D     +D A   + ++V     +L + + +VV P    +A+      Y  H+     I++YA     LS  D+ EL EIK      P+FF++        RL    +  +  L   L   + F   G  + N  A  SG                        + +P +             L+ QF+    +L+ +    +Q +LV    ++    S  L   I + +D+     ITPK++E+ +Q+E  LY SL+  S  K EE+  +I E LN M+ Q L DAA ++  D+   Q+ + VS++  K     ++E + S++N A+  KL+ S+D LR ++VGTLER + SL K ++E+ +   +  LK IL+  Y + +   + ST    + E++ Q+I R+ W   PT+   W  R + D + S+S  KL   + +Q  + LK SHE F  S+K+LE     R  K  ++  R+++ + P+LARL LE  SL+D +L G P++ RE+GRGQYGVVY C++WG +   A+KSVVPPDEKHW DLA+EF Y + + +H+R+  +HGSV+DY+Y  GS+ A+L I +R+ RD Y  LK GL   TRLQ++LDV+EGIRFLH+QGL+HRDIKLKNVLLD  +R K+TDLGFCKP AM+SGS+VGTPIHMAPELF+ +Y+ SVD+YAFGILFWY+CS  VK+P  F++  +K+ L+  V+KG RPER    D+ECW L+  CW+ DP++RPL G ++  L
Sbjct:  118 GKWDTIPEEDL-DVPEDEEDPAHRLAELEVTLPHQLL-QDVDIVVSPCRSSQAVSMTLEDYVDHVQS---IVVYAVCEERLSQQDEEELTEIKE-KYKLPVFFIRTSSTR--DRLIGGSEGVRSALYEQLME-LGFLKRG--LCNCGAAGSG------------------------STAPSM-------------LVEQFEKL-RQLSTFSRQVLQMHLVDAAIVLNMVHSRCLDLFINKAFDMHRDLQITPKRLEYTRQKENELYESLMRISDRKQEELKDMIVETLNSMREQLLEDAANMQFKDIAIPQNGEPVSVQEVKCCIFQIKELIISRLNQAVVNKLISSVDYLRESFVGTLERCLRSLEKSQQESSSHVTSNHLKQILNAAYHVEVTFNSGSTVTRMVWEQIVQIIQRITWVSPPTITPEWKRRVAQDAIESLSASKLAKSICSQFCKRLKSSHEAFAASLKQLEVGHSGRLEKTNDLWLRVRKDHAPRLARLSLESRSLQDVLLHGKPRIGRELGRGQYGVVYLCDSWGGHFPCALKSVVPPDEKHWNDLALEFHYMRSLPKHERLVDLHGSVIDYSYGGGSSIAVLLITERLHRDLYVGLKTGLSLETRLQIALDVVEGIRFLHNQGLVHRDIKLKNVLLDKKHRAKITDLGFCKPEAMMSGSIVGTPIHMAPELFSGKYDNSVDVYAFGILFWYICSGSVKLPEAFEKCASKDHLWNNVRKGARPERLAIFDEECWKLMEACWNGDPSQRPLMGIVQPML 839          

Query:  505 NKQDCINEEVLIDNAAKSDDEAFENSYVDVMHSSDILFEGIKVVVMPSIKQKAIEEIRAIYDSHISDLLPILIYAFEFNDLSSWDKTELEEIKLLAQDSPIFFVKVPPYEKYSRLPADYKFTKEELLAVLNPPISFAPNGRKVSNTNANDSGDMKLFGTLCQMNLISAVNNGFFSLTRSPKLETIDLNDLKIDSDLITQFDSFFEKLTNYCHSCIQKYLVRVLTIITKFASDALKNLILQVYDLSYSSVITPKKVEFAKQQELLLYNSLISRSTEKHEEICSLIGEILNIMK-QTLPDAAAVEI-DLESFQD-KMVSIKMYKSATNTVREYVASKVNSAIAEKLLQSMDVLRNTYVGTLERTVNSLGKFEEENIN--ATEALKNILHFTYGLHIPIKTSSTFMSSLIEKMKQLISRLPWQPDPTLDANWVMRTSSDMLNSISEVKLTHEVINQITENLKQSHENFIISIKRLENRVEVRQNKHAEMQDRIKRLYTPKLARLYLEGMSLRDNVLFGVPKLNREIGRGQYGVVYACNTWGAYNQMAVKSVVPPDEKHWCDLAMEFFYCKQMSEHDRIATIHGSVVDYNYSYGSNPAILFIMDRMARDFYAALKQGLDWVTRLQVSLDVIEGIRFLHSQGLIHRDIKLKNVLLDYNNRGKLTDLGFCKPCAMLSGSLVGTPIHMAPELFNQEYNFSVDIYAFGILFWYVCSNKVKVPTNFDRFTNKESLFEAVKKGLRPERPPKIDQECWDLISRCWHQDPNKRPLPGEIEDQL 2802
             K D I EE L D     +D A   + ++V     +L + + +VV P    +A+      Y  H+     I++YA     LS  D+ EL EIK      P+FF++        RL    +  +  L   L   + F   G  + N  A  SG                        + +P +             L+ QF+    +L+ +    +Q +LV    ++    S  L   I + +D+     ITPK++E+ +Q+E  LY SL+  S  K EE+  +I E LN M+ Q L DAA ++  D+   Q+ + VS++  K     ++E + S++N A+  KL+ S+D LR ++VGTLER + SL K ++E+ +   +  LK IL+  Y + +   + ST    + E++ Q+I R+ W   PT+   W  R + D + S+S  KL   + +Q  + LK SHE F  S+K+LE     R  K  ++  R+++ + P+LARL LE  SL+D +L G P++ RE+GRGQYGVVY C++WG +   A+KSVVPPDEKHW DLA+EF Y + + +H+R+  +HGSV+DY+Y  GS+ A+L I +R+ RD Y  LK GL   TRLQ++LDV+EGIRFLH+QGL+HRDIKLKNVLLD  +R K+TDLGFCKP AM+SGS+VGTPIHMAPELF+ +Y+ SVD+YAFGILFWY+CS  VK+P  F++  +K+ L+  V+KG RPER    D+ECW L+  CW+ DP++RPL G ++  L
Sbjct:  158 GKWDTIPEEDL-DVPEDEEDPAHRLAELEVTLPHQLL-QDVDIVVSPCRSSQAVSMTLEDYVDHVQS---IVVYAVCEERLSQQDEEELTEIKE-KYKLPVFFIRTSSTR--DRLIGGSEGVRSALYEQLME-LGFLKRG--LCNCGAAGSG------------------------STAPSM-------------LVEQFEKL-RQLSTFSRQVLQMHLVDAAIVLNMVHSRCLDLFINKAFDMHRDLQITPKRLEYTRQKENELYESLMRISDRKQEELKDMIVETLNSMREQLLEDAANMQFKDIAIPQNGEPVSVQEVKCCIFQIKELIISRLNQAVVNKLISSVDYLRESFVGTLERCLRSLEKSQQESSSHVTSNHLKQILNAAYHVEVTFNSGSTVTRMVWEQIVQIIQRITWVSPPTITPEWKRRVAQDAIESLSASKLAKSICSQFCKRLKSSHEAFAASLKQLEVGHSGRLEKTNDLWLRVRKDHAPRLARLSLESRSLQDVLLHGKPRIGRELGRGQYGVVYLCDSWGGHFPCALKSVVPPDEKHWNDLALEFHYMRSLPKHERLVDLHGSVIDYSYGGGSSIAVLLITERLHRDLYVGLKTGLSLETRLQIALDVVEGIRFLHNQGLVHRDIKLKNVLLDKKHRAKITDLGFCKPEAMMSGSIVGTPIHMAPELFSGKYDNSVDVYAFGILFWYICSGSVKLPEAFEKCASKDHLWNNVRKGARPERLAIFDEECWKLMEACWNGDPSQRPLMGIVQPML 879          

Query:  505 NKQDCINEEVLIDNAAKSDDEAFENSYVDVMHSSDILFEGIKVVVMPSIKQKAIEEIRAIYDSHISDLLPILIYAFEFNDLSSWDKTELEEIKLLAQDSPIFFVKVPPYEKYSRLPADYKFTKEELLAVLNPPISFAPNGRKVSNTNANDSGDMKLFGTLCQMNLISAVNNGFFSLTRSPKLETIDLNDLKIDSDLITQFDSFFEKLTNYCHSCIQKYLVRVLTIITKFASDALKNLILQVYDLSYSSVITPKKVEFAKQQELLLYNSLISRSTEKHEEICSLIGEILNIMK-QTLPDAAAVEI-DLESFQD-KMVSIKMYKSATNTVREYVASKVNSAIAEKLLQSMDVLRNTYVGTLERTVNSLGKFEEENIN--ATEALKNILHFTYGLHIPIKTSSTFMSSLIEKMKQLISRLPWQPDPTLDANWVMRTSSDMLNSISEVKLTHEVINQITENLKQSHENFIISIKRLENRVEVRQNKHAEMQDRIKRLYTPKLARLYLEGMSLRDNVLFGVPKLNREIGRGQYGVVYACNTWGAYNQMAVKSVVPPDEKHWCDLAMEFFYCKQMSEHDRIATIHGSVVDYNYSYGSNPAILFIMDRMARDFYAALKQGLDWVTRLQVSLDVIEGIRFLHSQGLIHRDIKLKNVLLDYNNRGKLTDLGFCKPCAMLSGSLVGTPIHMAPELFNQEYNFSVDIYAFGILFWYVCSNKVKVPTNFDRFTNKESLFEAVKKGLRPERPPKIDQECWDLISRCWHQDPNKRPLPGEIEDQL 2802
             K D I EE L D     +D A   + ++V     +L + + +VV P    +A+      Y  H+     I++YA     LS  D+ EL EIK      P+FF++        RL    +  +  L   L   + F   G  + N  A  SG                        + +P +             L+ QF+    +L+ +    +Q +LV    ++    S  L   I + +D+     ITPK++E+ +Q+E  LY SL+  S  K EE+  +I E LN M+ Q L DAA ++  D+   Q+ + VS++  K     ++E + S++N A+  KL+ S+D LR ++VGTLER + SL K ++E+ +   +  LK IL+  Y + +   + ST    + E++ Q+I R+ W   PT+   W  R + D + S+S  KL   + +Q  + LK SHE F  S+K+LE     R  K  ++  R+++ + P+LARL LE  SL+D +L G P++ RE+GRGQYGVVY C++WG +   A+KSVVPPDEKHW DLA+EF Y + + +H+R+  +HGSV+DY+Y  GS+ A+L I +R+ RD Y  LK GL   TRLQ++LDV+EGIRFLH+QGL+HRDIKLKNVLLD  +R K+TDLGFCKP AM+SGS+VGTPIHMAPELF+ +Y+ SVD+YAFGILFWY+CS  VK+P  F++  +K+ L+  V+KG RPER    D+ECW L+  CW+ DP++RPL G ++  L
Sbjct:  176 GKWDTIPEEDL-DVPEDEEDPAHRLAELEVTLPHQLL-QDVDIVVSPCRSSQAVSMTLEDYVDHVQS---IVVYAVCEERLSQQDEEELTEIKE-KYKLPVFFIRTSSTR--DRLIGGSEGVRSALYEQLME-LGFLKRG--LCNCGAAGSG------------------------STAPSM-------------LVEQFEKL-RQLSTFSRQVLQMHLVDAAIVLNMVHSRCLDLFINKAFDMHRDLQITPKRLEYTRQKENELYESLMRISDRKQEELKDMIVETLNSMREQLLEDAANMQFKDIAIPQNGEPVSVQEVKCCIFQIKELIISRLNQAVVNKLISSVDYLRESFVGTLERCLRSLEKSQQESSSHVTSNHLKQILNAAYHVEVTFNSGSTVTRMVWEQIVQIIQRITWVSPPTITPEWKRRVAQDAIESLSASKLAKSICSQFCKRLKSSHEAFAASLKQLEVGHSGRLEKTNDLWLRVRKDHAPRLARLSLESRSLQDVLLHGKPRIGRELGRGQYGVVYLCDSWGGHFPCALKSVVPPDEKHWNDLALEFHYMRSLPKHERLVDLHGSVIDYSYGGGSSIAVLLITERLHRDLYVGLKTGLSLETRLQIALDVVEGIRFLHNQGLVHRDIKLKNVLLDKKHRAKITDLGFCKPEAMMSGSIVGTPIHMAPELFSGKYDNSVDVYAFGILFWYICSGSVKLPEAFEKCASKDHLWNNVRKGARPERLAIFDEECWKLMEACWNGDPSQRPLMGIVQPML 897          

Query:  256 PMEIDNETRFLTDKDLSLIIMGQTHYTKSVIVNEIFKKRIMP-IKYDQ-PNAPWKMIKFHYGIKTITSLCEFDNAFDLGDRTNLLNKQD---CINEEVLIDNAAKSDDEAFENSYVDV---MHSSDILFEGIKVVVMPSIKQKAIEEIRAIYDSHISDLLPILIYAFEFNDLSSWDKTELEEIKLLAQDSPIFFVKVPPYEKYSRLPADYKFTKEELLAVLNPPISFAPNGRKVSNTNANDSGDMKLFGTLCQMNLISAVNNGFFSLTRSPKLETIDLNDLKIDSDLITQFDSFFEKLTNYCHSCIQKYLVRVLTIITKFASDALKNLILQVYDLSYSSVITPKKVEFAKQQELLLYNSLISRSTEKHEEICSLIGEILNIMKQTLPDAAAVEIDLESFQDKMV-------SIKMYKSATNTVREYVASKVNSAIAEKLLQSMDVLRNTYVGTLERTVNSLGKFEEENINATEA-LKNILHFTYGLHIPIKTSSTFMSSLIEKMKQLISRLPWQPDPTLDANWVMRTSSDMLNSISEVKLTHEVINQITENLKQSHENFIISIKRLENRVEVRQNKHAEMQDRIKRLYTPKLARLYLEGMSLRDNVLFGVPKLNREIGRGQYGVVYACNTWGAYNQMAVKSVVPPDEKHWCDLAMEFFYCKQMSEHDRIATIHGSVVDYNYSYGSNPAILFIMDRMARDFYAALKQGLDWVTRLQVSLDVIEGIRFLHSQGLIHRDIKLKNVLLDYNNRGKLTDLGFCKPCAMLSGSLVGTPIHMAPELFNQEYNFSVDIYAFGILFWYVCSNKVKVPTNFDRFTNKESLFEAVKKGLRPERPPKIDQECWDLISRCWHQDPNKRPLPGEIEDQL 2802
            PME +   + L D+   ++I+GQ    K  ++N +   +++P +K D   +   + ++F YG +T  SL      ++L     L + QD    I EE   D   + D E   +   D+   MH +  L + + +VV P    +   ++        +D LP++ YA   ++LS   + EL E++      P+FF KVP  E  S                              S++   +S    L+G L  +  +S+ +       +          D K  S L+ Q +   ++L+ + H  +Q  LV     +    S  L   I Q +D+     ITPK++E+ +++E  LY SL++ +  K EE+  +I E LN MK+ L D AA   ++E F+D +V         +  KS    ++E + S++N A+A KL+ S+D LR ++VGTLER + SL K ++ +++ T   LK IL+  Y + +   + S+    L E++KQ+I R+ W   PT+   W  + + + ++S+S  KL   + +Q    L  SHE F  S+++LE     R  K  ++  ++++ + P+LARL LE  SL+D +L   PKL +E+GRGQYGVVY C+ WG +   A+KSVVPPDEKHW DLA+EF Y + + +H+R+  +HGSV+DYNY  GS+ A+L IM+R+ RD Y  LK GL   TRLQ++LDV+EGIRFLHSQGL+HRDIKLKNVLLD  NR K+TDLGFCKP AM+SGS+VGTPIHMAPELF  +Y+ SVD+YAFGILFWY+CS  +K+P  F+R  +K+ L+  V++G RPER P  D+ECW L+  CW  DP KRPL G ++  L
Sbjct:   98 PME-ETYLQQLVDRLPCILILGQDCNAKCQLLNLLLGVQVLPTLKLDSDESCKLRRLRFTYGTRTRVSLA-LPGQYELVH--TLASHQDNWETIPEE---DLEVQEDSEDAAHVLADLEVTMHHA--LLQEVDIVVAPCPSHRPSVDV---LSDLANDFLPVITYALHKDELSERGEQELREVRQYF-SFPMFFFKVPKLEIIS------------------------------SSSGRAESERSPLYGQLVDLGYLSSSHRNCVPSDQ----------DCKAQSMLVEQSEKL-KQLSTFSHQLLQNRLVDAAKALNVVHSHCLDIFINQAFDMQRDLQITPKRLEYTRKKENELYESLMNIANRKQEEMKDMIVETLNTMKEELLDDAA---NME-FKDVIVPENGETIGTREIKSCIRQIQELIISRLNQAVANKLISSVDYLRESFVGTLERCLQSLEKSQDVSVHITSNYLKQILNAAYHVEVTFHSGSSVTRMLWEQIKQIIQRITWVNPPTITLEWKRKVAQEAIDSLSASKLAKSICSQFRTRLNSSHEAFAASLRQLEAGHSGRLEKTEDLWLKVRKDHAPRLARLSLESRSLQDVLLHRKPKLGQELGRGQYGVVYLCDNWGGHFPCALKSVVPPDEKHWNDLALEFHYMRSLPKHERLVDLHGSVIDYNYGGGSSVAVLLIMERLHRDLYTGLKAGLTLETRLQIALDVVEGIRFLHSQGLVHRDIKLKNVLLDKQNRAKITDLGFCKPEAMMSGSIVGTPIHMAPELFTGKYDNSVDVYAFGILFWYICSGSIKLPEAFERCASKDHLWNNVRRGTRPERLPVFDEECWQLMEACWDGDPLKRPLLGIVQPML 904          

Query:  256 PMEIDNETRFLTDKDLSLIIMGQTHYTKSVIVNEIFKKRIMP-IKYDQ-PNAPWKMIKFHYGIKTITSLCEFDNAFDLGDRTNLLNKQD---CINEEVLIDNAAKSDDEAFENSYVDV---MHSSDILFEGIKVVVMPSIKQKAIEEIRAIYDSHISDLLPILIYAFEFNDLSSWDKTELEEIKLLAQDSPIFFVKVPPYEKYSRLPADYKFTKEELLAVLNPPISFAPNGRKVSNTNANDSGDMKLFGTLCQMNLISAVNNGFFSLTRSPKLETIDLNDLKIDSDLITQFDSFFEKLTNYCHSCIQKYLVRVLTIITKFASDALKNLILQVYDLSYSSVITPKKVEFAKQQELLLYNSLISRSTEKHEEICSLIGEILNIMKQTLPDAAAVEIDLESFQDKMV-------SIKMYKSATNTVREYVASKVNSAIAEKLLQSMDVLRNTYVGTLERTVNSLGKFEEENINATEA-LKNILHFTYGLHIPIKTSSTFMSSLIEKMKQLISRLPWQPDPTLDANWVMRTSSDMLNSISEVKLTHEVINQITENLKQSHENFIISIKRLENRVEVRQNKHAEMQDRIKRLYTPKLARLYLEGMSLRDNVLFGVPKLNREIGRGQYGVVYACNTWGAYNQMAVKSVVPPDEKHWCDLAMEFFYCKQMSEHDRIATIHGSVVDYNYSYGSNPAILFIMDRMARDFYAALKQGLDWVTRLQVSLDVIEGIRFLHSQGLIHRDIKLKNVLLDYNNRGKLTDLGFCKPCAMLSGSLVGTPIHMAPELFNQEYNFSVDIYAFGILFWYVCSNKVKVPTNFDRFTNKESLFEAVKKGLRPERPPKIDQECWDLISRCWHQDPNKRPLPGEIEDQL 2802
            PME +   + L D+   ++I+GQ    K  ++N +   +++P +K D   +   + ++F YG +T  SL      ++L     L + QD    I EE   D   + D E   +   D+   MH +  L + + +VV P    +   ++        +D LP++ YA   ++LS   + EL E++      P+FF KVP  E  S                              S++   +S    L+G L  +  +S+ +       +          D K  S L+ Q +   ++L+ + H  +Q  LV     +    S  L   I Q +D+     ITPK++E+ +++E  LY SL++ +  K EE+  +I E LN MK+ L D AA   ++E F+D +V         +  KS    ++E + S++N A+A KL+ S+D LR ++VGTLER + SL K ++ +++ T   LK IL+  Y + +   + S+    L E++KQ+I R+ W   PT+   W  + + + ++S+S  KL   + +Q    L  SHE F  S+++LE     R  K  ++  ++++ + P+LARL LE  SL+D +L   PKL +E+GRGQYGVVY C+ WG +   A+KSVVPPDEKHW DLA+EF Y + + +H+R+  +HGSV+DYNY  GS+ A+L IM+R+ RD Y  LK GL   TRLQ++LDV+EGIRFLHSQGL+HRDIKLKNVLLD  NR K+TDLGFCKP AM+SGS+VGTPIHMAPELF                                              G RPER P  D+ECW L+  CW  DP KRPL G ++  L
Sbjct:   98 PME-ETYLQQLVDRLPCILILGQDCNAKCQLLNLLLGVQVLPTLKLDSDESCKLRRLRFTYGTRTRVSLA-LPGQYELVH--TLASHQDNWETIPEE---DLEVQEDSEDAAHVLADLEVTMHHA--LLQEVDIVVAPCPSHRPSVDV---LSDLANDFLPVITYALHKDELSERGEQELREVRQYF-SFPMFFFKVPKLEIIS------------------------------SSSGRAESERSPLYGQLVDLGYLSSSHRNCVPSDQ----------DCKAQSMLVEQSEKL-KQLSTFSHQLLQNRLVDAAKALNVVHSHCLDIFINQAFDMQRDLQITPKRLEYTRKKENELYESLMNIANRKQEEMKDMIVETLNTMKEELLDDAA---NME-FKDVIVPENGETIGTREIKSCIRQIQELIISRLNQAVANKLISSVDYLRESFVGTLERCLQSLEKSQDVSVHITSNYLKQILNAAYHVEVTFHSGSSVTRMLWEQIKQIIQRITWVNPPTITLEWKRKVAQEAIDSLSASKLAKSICSQFRTRLNSSHEAFAASLRQLEAGHSGRLEKTEDLWLKVRKDHAPRLARLSLESRSLQDVLLHRKPKLGQELGRGQYGVVYLCDNWGGHFPCALKSVVPPDEKHWNDLALEFHYMRSLPKHERLVDLHGSVIDYNYGGGSSVAVLLIMERLHRDLYTGLKAGLTLETRLQIALDVVEGIRFLHSQGLVHRDIKLKNVLLDKQNRAKITDLGFCKPEAMMSGSIVGTPIHMAPELFT---------------------------------------------GTRPERLPVFDEECWQLMEACWDGDPLKRPLLGIVQPML 859          

Query: 2044 LNREIGRGQYGVVYACNTWGAYNQMAVKSVVPPDEKHWCDLAMEFFYCKQMS---EHDRIATIHGSVVDYNYSYGSNPAILFIMDRMARDFYAALKQGLDWVTRLQVSLDVIEGIRFLHSQGLIHRDIKLKNVLLDYNNRGKLTDLGFCKPCAMLSG---SLVGTPIHM---APELFNQ-EYNFSVDIYAFGILFWYVCSNKVKVPTNFDRFTNKESLFEAVKKGLRPERPPKIDQECWDLISRCWHQDPNKRP 2775
            L +E+G GQ+GVV     W     +AVK +     K       EFF   Q      H ++   +G     +  Y       +I +    ++  +  +GL+    L++  DV EG+ FL S   IHRD+  +N L+D +   K++D G  +   +L     S VGT   +   APE+F+  +Y+   D++AFGIL W V S   K P  +D + N E + + V +G R  RP       + ++  CWH+ P KRP
Sbjct:  399 LLKELGNGQFGVV-QLGQWKGQYDVAVKMI-----KEGAMSEDEFFQEAQTMMKLSHPKLVKFYGVC---SKKYPIYIVTEYITNGCLLNYLKSHGKGLESCQLLEMCYDVCEGMAFLESHQFIHRDLAARNCLVDSDLSVKVSDFGMTR--YVLDDQYVSSVGTKFPVKWSAPEVFHYFKYSSKSDVWAFGILMWEVFSLG-KQP--YDLYDNSEVVVK-VSQGHRLYRPQLASDTIYQIMYSCWHELPEKRP 637          

Query: 2044 LNREIGRGQYGVVYACNTWGAYNQMAVKSVVPPDEKHWCDLAMEFFYCKQMS---EHDRIATIHGSVVDYNYSYGSNPAILFIMDRMARDFYAALKQGLDWVTRLQVSLDVIEGIRFLHSQGLIHRDIKLKNVLLDYNNRGKLTDLGFCKPCAMLSG---SLVGTPIHM---APELFNQ-EYNFSVDIYAFGILFWYVCSNKVKVPTNFDRFTNKESLFEAVKKGLRPERPPKIDQECWDLISRCWHQDPNKRP 2775
            L +E+G GQ+GVV     W     +AVK +     K       EFF   Q      H ++   +G     +  Y       +I +    ++  +  +GL+    L++  DV EG+ FL S   IHRD+  +N L+D +   K++D G  +   +L     S VGT   +   APE+F+  +Y+   D++AFGIL W V S   K P  +D + N E + + V +G R  RP       + ++  CWH+ P KRP
Sbjct:  395 LLKELGNGQFGVV-QLGQWKGQYDVAVKMI-----KEGAMSEDEFFQEAQTMMKLSHPKLVKFYGVC---SKKYPIYIVTEYITNGCLLNYLKSHGKGLESCQLLEMCYDVCEGMAFLESHQFIHRDLAARNCLVDSDLSVKVSDFGMTR--YVLDDQYVSSVGTKFPVKWSAPEVFHYFKYSSKSDVWAFGILMWEVFSLG-KQP--YDLYDNSEVVVK-VSQGHRLYRPQLASDTIYQIMYSCWHELPEKRP 633          

Query: 2356 SLDVIEGIRFLHSQGLIHRDIKLKNVLLDYNNRGKLTDLGFCKPCAMLSG---SLVGTPIHMAPELFNQ-EYNFSVDIYAFGILFWYVCSNKVKVPTNFDRFTNKESLFEAVKKGLRPERPPKIDQECWDLISRCWHQDPNKR 2772
            + ++I G++FLHS+G+I+RD+KL NV+LD +   K+ D G CK      G   +  GTP ++APE+    +Y+FSVD ++FG+L + +     + P + D   +++ LFE+++    P  P  I +E  D++ + + +DP+KR
Sbjct:  452 AAEIICGLQFLHSKGIIYRDLKLDNVMLDRDGHIKIADFGMCKENIFGEGRASTFCGTPDYIAPEILQGLKYSFSVDWWSFGVLLYEMLIG--QSPFHGD---DEDELFESIRVDT-PHYPRWITKESKDIMEKLFERDPDKR 588          

Query:  256 PMEIDNETRFLTDKDLSLIIMGQTHYTKSVIVNEIFKKRIMP-IKYDQ-PNAPWKMIKFHYGIKTITSLCEFDNAFDLGDRTNLLNKQD---CINEEVLIDNAAKSDDEAFENSYVDV---MHSSDILFEGIKVVVMPSIKQKAIEEIRAIYDSHISDLLPILIYAFEFNDLSSWDKTELEEIKLLAQDSPIFFVKVPPYEKYSRLPADYKFTKEELLAVLNPPISFAPNGRKVSNTNANDSGDMKLFGTLCQMNLISAVNNGFFSLTRSPKLETIDLNDLKIDSDLITQFDSFFEKLTNYCHSCIQKYLVRVLTIITKFASDALKNLILQVYDLSYSSVITPKKVEFAKQQELLLYNSLISRSTEKHEEICSLIGEILNIMKQTLPDAAAVEIDLESFQD-------KMVSIKMYKSATNTVREYVASKVNSAIAEKLLQSMDVLRNTYVGTLERTVNSLGKFEEENINATEA-LKNILHFTYGLHIPIKTSSTFMSSLIEKMKQLISRLPWQPDPTLDANWVMRTSSDMLNSISEVKLTHEVINQITENLKQSHENFIISIKRLENRVEVRQNKHAEMQDRIKRLYTPKLARLYLEGMSLRDNVLFGVPKLNREIGRGQYGVVYACNTWGAYNQMAVKSVVPPDEKHWCDLAMEFFYCKQMSEHDRIATIHGSVVDYNYSYGSNPAILFIMDRMARDFYAALKQGLDWVTRLQVSLDVIEGIRFLHSQGLIHRDIKLKNVLLDYNNRGKLTDLGFCKPCAMLSGSLVGTPIHMAPELFNQEYNFSVDIYAFGILFWYVCSNKVKVPTNFDRFTNKESLFEAVKKGLRPERPPKIDQECWDLISRCWHQDPNKRPLPGEIE 2793
            PME +   + + D    ++I+GQ    K  ++N +   R++P +K D   +   + ++F YG +T  SL      ++L     L + QD    I EE   D   + D E       D+   MH +  L + + +VV P    +   ++        +D LP++ YA   ++LS  D+ EL+EI+      P+FF KVP  E                       I  + +GR        DS    L G L  +  +S+ +    +  +          D +  S L+ Q +    +L+ + H  +Q  LV     +    S  L   I Q +D+     ITPK++E+ +++E  LY SL++ +  K EE+  +I E LN MK+ L D AA   ++E F+D       + V  +  KS    ++E + S++N A+A KL+ S+D LR ++VGTLER + SL K ++ +++ T   LK IL+  Y + +   + S+    L E++KQ+I R+ W   PT+   W  + + + ++S+S  KL   + +Q    L  SHE F  S+++LE     R  K  ++  ++++ + P+LARL LE  SL+D +L   PKL +E+GRGQYGVVY C+ WG +   A+KSVVPPDEKHW DLA+EF Y + + +H+R+  +HGSV+DYNY  GS+ A+L IM+R+ RD Y  LK GL   TRLQ++LDV+EGIRFLHSQGL+HRDIKLKNVLLD  NR K+TDLGFCKP AM+SGS+VGTPIHMAPELF  +Y+ SVD+YAFGILFWY+CS  +K+P  F+R  +K+ L+  V++G RPER P  D+ECW L+  CW  DP+KRPL G ++
Sbjct:   98 PME-EKYLQQIVDHLPCILILGQDCNAKCQLLNLLLAVRVLPTLKLDSDESCKLRRLRFTYGTRTQVSLA-LPGQYELVH--TLASHQDNWETIPEE---DLEVQEDSEDTARVLADLEVTMHHA--LLQEVDIVVAPCHSHRPAVDV---LSDLANDFLPVITYALHKDELSERDEQELQEIRKYF-SFPVFFFKVPTLE-----------------------IIRSSSGRA-------DSERSPLSGQLMDLGYLSSSHRNCMASDQ----------DCRAQSMLVEQSEKL-RQLSTFSHQLLQTRLVDAAKALNAVHSHCLDIFINQAFDMQRDLQITPKRLEYTRKKENELYESLMNIANRKQEEMKDMIVETLNTMKEELLDDAA---NME-FKDVIVPENGETVGTREIKSCIRQIQELIISRLNQAVANKLISSVDYLRESFVGTLERCLQSLEKSQDVSVHITSNYLKQILNAAYHVEVTFHSGSSVTRMLWEQIKQIIQRITWVNPPTITLEWKRKVAQEAIDSLSASKLAKSICSQFRTRLNSSHEAFAASLRQLEAGHSGRLEKTEDLWLKVRKDHAPRLARLSLESRSLQDVLLHRKPKLGQELGRGQYGVVYLCDNWGGHFPCALKSVVPPDEKHWNDLALEFHYMRSLPKHERLVDLHGSVIDYNYGGGSSVAVLLIMERLHRDLYTGLKAGLSLETRLQIALDVVEGIRFLHSQGLVHRDIKLKNVLLDKQNRAKITDLGFCKPEAMMSGSIVGTPIHMAPELFTGKYDNSVDVYAFGILFWYICSGSIKLPEAFERCASKDHLWNNVRRGTRPERLPVFDEECWQLMEACWDGDPSKRPLLGIVQ 901          

Query:  256 PMEIDNETRFLTDKDLSLIIMGQTHYTKSVIVNEIFKKRIMP-IKYDQ-PNAPWKMIKFHYGIKTITSLCEFDNAFDLGDRTNLLNKQD---CINEEVLIDNAAKSDDEAFENSYVDV---MHSSDILFEGIKVVVMPSIKQKAIEEIRAIYDSHISDLLPILIYAFEFNDLSSWDKTELEEIKLLAQDSPIFFVKVPPYEKYSRLPADYKFTKEELLAVLNPPISFAPNGRKVSNTNANDSGDMKLFGTLCQMNLISAVNNGFFSLTRSPKLETIDLNDLKIDSDLITQFDSFFEKLTNYCHSCIQKYLVRVLTIITKFASDALKNLILQVYDLSYSSVITPKKVEFAKQQELLLYNSLISRSTEKHEEICSLIGEILNIMKQTLPDAAAVEIDLESFQDKMV-------SIKMYKSATNTVREYVASKVNSAIAEKLLQSMDVLRNTYVGTLERTVNSLGKFEEENINATEA-LKNILHFTYGLHIPIKTSSTFMSSLIEKMKQLISRLPWQPDPTLDANWVMRTSSDMLNSISEVKLTHEVINQITENLKQSHENFIISIKRLENRVEVRQNKHAEMQDRIKRLYTPKLARLYLEGMSLRDNVLFGVPKLNREIGRGQYGVVYACNTWGAYNQMAVKSVVPPDEKHWCDLAMEFFYCKQMSEHDRIATIHGSVVDYNYSYGSNPAILFIMDRMARDFYAALKQGLDWVTRLQVSLDVIEGIRFLHSQGLIHRDIKLKNVLLDYNNRGKLTDLGFCKPCAMLSGSLVGTPIHMAPELFNQEYNFSVDIYAFGILFWYVCSNKVKVPTNFDRFTNKESLFEAVKKGLRPERPPKIDQECWDLISRCWHQDPNKRPLPGEIEDQL 2802
            PME +   + L D+   ++I+GQ    K  ++N +   +++P +K D   +   + ++F YG +T  SL      ++L     L + QD    I EE   D   + D E   +   D+   MH +  L + + +VV P    +   ++        +D LP++ YA   ++LS   + EL E++      P+FF KVP  E  S                              S++   +S    L+G L  +  +S+ +       +          D K  S L+ Q +   ++L+ + H  +Q  LV     +    S  L   I Q +D+     ITPK++E+ +++E  LY SL++ +  K EE+  +I E LN MK+ L D AA   ++E F+D +V         +  KS    ++E + S++N A+A KL+ S+D LR ++VGTLER + SL K ++ +++ T   LK IL+  Y + +   + S+    L E++KQ+I R+ W   PT+   W  + + + ++S+S  KL   + +Q    L  SHE F  S+++LE     R  K  ++  ++++ + P+LARL LE  SL+D +L   PKL +E+GRGQYGVVY C+ WG +   A+KSVVPPDEKHW DLA+EF Y + + +H+R+  +HGSV+DYNY  GS+ A+L IM+R+ RD Y  LK GL   TRLQ++LDV+EGIRFLHSQGL+HRDIKLKNVLLD  NR K+TDLGFCKP AM+SGS+VGTPIHMAPELF  +Y+ SVD+YAFGILFWY+CS  +K+P  F+R  +K+ L+  V++G RPER P  D+ECW L+  CW  DP KRPL G ++  L
Sbjct:   98 PME-ETYLQQLVDRLPCILILGQDCNAKCQLLNLLLGVQVLPTLKLDSDESCKLRRLRFTYGTRTRVSLA-LPGQYELVH--TLASHQDNWETIPEE---DLEVQEDSEDAAHVLADLEVTMHHA--LLQEVDIVVAPCPSHRPSVDV---LSDLANDFLPVITYALHKDELSERGEQELREVRQYF-SFPMFFFKVPKLEIIS------------------------------SSSGRAESERSPLYGQLVDLGYLSSSHRNCVPSDQ----------DCKAQSMLVEQSEKL-KQLSTFSHQLLQNRLVDAAKALNVVHSHCLDIFINQAFDMQRDLQITPKRLEYTRKKENELYESLMNIANRKQEEMKDMIVETLNTMKEELLDDAA---NME-FKDVIVPENGETIGTREIKSCIRQIQELIISRLNQAVANKLISSVDYLRESFVGTLERCLQSLEKSQDVSVHITSNYLKQILNAAYHVEVTFHSGSSVTRMLWEQIKQIIQRITWVNPPTITLEWKRKVAQEAIDSLSASKLAKSICSQFRTRLNSSHEAFAASLRQLEAGHSGRLEKTEDLWLKVRKDHAPRLARLSLESRSLQDVLLHRKPKLGQELGRGQYGVVYLCDNWGGHFPCALKSVVPPDEKHWNDLALEFHYMRSLPKHERLVDLHGSVIDYNYGGGSSVAVLLIMERLHRDLYTGLKAGLTLETRLQIALDVVEGIRFLHSQGLVHRDIKLKNVLLDKQNRAKITDLGFCKPEAMMSGSIVGTPIHMAPELFTGKYDNSVDVYAFGILFWYICSGSIKLPEAFERCASKDHLWNNVRRGTRPERLPVFDEECWQLMEACWDGDPLKRPLLGIVQPML 904          

Query:  307 LIIMGQTHYTKSVIVNEIFKKRIMPIK--YDQPNAPWKMIKFHYGIKTITSLCEFDNAFDLGDRTNLLNKQDCINEEVLIDNAAKSDDEAFENSYVDVMHSSDILFEGIKVVVMPSIKQKAIEEIRAIYDSHISDLLPILIYAFEFNDLSSWDKTELEEIKLLAQDSPIFFVKVPPYEKYSRLPADYKFTKEELLAVLNPPISFAPNGRKVSNTNANDSGDMKLFGTLCQ-MNLISAVNNGFFSLTRSPKLETIDLNDLKIDSDLITQFDSFFEKLTNYCHSCIQKYLVRVLTIITKFASDALKNLILQVYDLSYSSVITPKKVEFAKQQELLLYNSLISRSTEKHEEICSLIGEILNIMKQTL-PDAAAVEIDLESFQD-------KMVSIKMYKSATNTVREYVASKVNSAIAEKLLQSMDVLRNTYVGTLERTVNSLGKFEEENINATEAL---------------KNILHFTYGLHIPIKTSSTFMSSLIEKMKQLISRLPWQPDPTLDANWVMRTSSDMLNSISEVKLTHEVINQITENLKQSHENFIISIKRLENRVEVRQNKHAEMQDRIKRLYTPKLARLYLEGMSLRDNVLFGVPKLNREIGRGQYGVVYACNTWGAYNQMAVKSVVPPDEKHWCDLAMEFFYCKQMSEHDRIATIHGSVVDYNYSYGSNPAILFIMDRMARDFYAALKQGLDWVTRLQVSLDVIEGIRFLHSQGLIHRDIKLKNVLLDYNNRGKLTDLGFCKPCAMLSGSLVGTPIHMAPELFNQEYNFSVDIYAFGILFWYVCSNKVKVPTNFDRFTNKESLFEAVKKGLRPERPPKIDQECWDLISRCWHQDPNKRPLPGEIEDQL 2802
            L+I+GQ    K  ++N +  ++++P      + N   + I+F +G +T  SL   +    +          D I EE L +    S+D A   + ++V+    +L E + VVV P    +  +   A  + +++ +L I+I+A    +LSS D+ EL EIK      PIFF KVP                E  + +++P        +K  N  ++           CQ M+L     N       SP        D    S L+ Q +     L+ +    +QK+LV   T + +     L   I Q +D+     ITPK++E+ +++E  LY SL++ +  K EE+  +I E L+ MK+ L  DAA +E     F+D       + VS K  K     ++E + S++N A+A KL+ S+D LR ++VGTLER + SL +  E +++   +L               K IL+  Y + +   + ST    L E++KQ+I R+ W   P + ++W  + + D + S+S  KL   + +Q    L  SHE F  S+++LE+    R  K  ++  ++++ + P+LARL LE  SL+D +L G PKL RE+GRGQYGVVY C++WG +   A+KSVVPPDEKHW DLA+EF Y + +  H+R+  +HGSV+DY Y  GS+ A+L IM+R+ RD Y  LK GL+  TRLQ++LDV+EGIR+LHSQGL+HRDIKLKNVLLD  NR K+TDLGFCKP AM+SGS+VGTPIHMAPELF  +Y+ SVD+YAFGILFWY+CS  VK+P  F+R  +K+ L+  V++G+RPER P  D+ECW L+  CW  D ++RPL G ++  L
Sbjct:  103 LLILGQNCNAKCQLLNILLGEKLLPTTKISSEENCKRRRIRFTHGTQTRVSLALPEQYELVHMMAAHRGHWDTIPEEDL-EIRGDSEDPAHRIAELEVVLPYSLLKE-VDVVVAPC---RGFQSAEATLEEYMNQVLLIVIFAISEAELSSSDENELREIKE-KFSLPIFFFKVP----------------ESGVELISP--------KKTDNEKSS---------LYCQLMDLEYLSTNHCSCGAPSP--------DAVAQSMLVEQLEKL-RLLSTFSRQVLQKHLVEAATSLNEVHCRCLNIFINQAFDMQRDLQITPKRLEYTRRKENELYESLMNIANRKQEEMKDMIIETLSNMKEELLEDAANME-----FKDIIIPENGEPVSSKDIKCCIKQIQELIISRLNQAVANKLISSVDYLRESFVGTLERCLKSLEESWEVSVHPARSLEKSKDVSVHITSNYLKQILNAAYHVEVTFHSGSTVTRMLWEQIKQIIQRITWVSPPAITSDWKRKVAQDAIESLSASKLAKSICSQFRTRLNSSHEAFAASLRQLEDGHSGRLEKTEDLWLKVRKDHAPRLARLSLESRSLQDVLLHGKPKLGRELGRGQYGVVYLCDSWGGHFPCALKSVVPPDEKHWNDLALEFHYMRSLQSHERLVDLHGSVIDYGYGGGSSIAVLLIMERLHRDLYTGLKAGLELETRLQIALDVVEGIRYLHSQGLVHRDIKLKNVLLDKKNRAKITDLGFCKPEAMMSGSIVGTPIHMAPELFTGKYDNSVDVYAFGILFWYICSGHVKLPEAFERCASKDHLWNNVRRGVRPERLPVFDEECWQLMEACWDGDSSQRPLLGIVQPML 907          

Query:  514 DCINEEVLIDNAAKSDDEAFENSYVDV-MHSSDILFEGIKVVVMPSIKQKAIEEIRAIYDSHISDLLPILIYAFEFNDLSSWDKTELEEIKLLAQDSPIFFVKVPPYEKYSRLPADYKFTKEELLAVLNPPISFAPNGRKVSNTNANDSGDMKLFGTLCQMNLISAVNNGFFSLTRSPKLETIDLNDLKIDSDLITQFDSFFEKLTNYCHSCIQKYLVRVLTIITKFASDALKNLILQVYDLSYSSVITPKKVEFAKQQELLLYNSLISRSTEKHEEICSLIGEILNIMKQTLPDAAAVEIDLESFQD-------KMVSIKMYKSATNTVREYVASKVNSAIAEKLLQSMDVLRNTYVGTLERTVNSLGKFEEENINATEA-LKNILHFTYGLHIPIKTSSTFMSSLIEKMKQLISRLPWQPDPTLDANWVMRTSSDMLNSISEVKLTHEVINQITENLKQSHENFIISIKRLENRVEVRQNKHAEMQDRIKRLYTPKLARLYLEGMSLRDNVLFGVPKLNREIGRGQYGVVYACNTWGAYNQMAVKSVVPPDEKHWCDLAMEFFYCKQMSEHDRIATIHGSVVDYNYSYGSNPAILFIMDRMARDFYAALKQGLDWVTRLQVSLDVIEGIRFLHSQGLIHRDIKLKNVLLDYNNRGKLTDLGFCKPCAMLSGSLVGTPIHMAPELFNQEYNFSVDIYAFGILFWYVCSNKVKVPTNFDRFTNKESLFEAVKKGLRPERPPKIDQECWDLISRCWHQDPNKRPLPGEIEDQL 2802
            D I EE L +    S+D A   + ++V MH +  L + + +VV P    + +     +    ++D LP++ YA   ++LS  D+ EL+EI+      PIFF KVP            K   E            A + R+  N  +     +   G L      S  N G            +   D K  S L+ Q +     L+ + H  +Q +LV     + +     L   I Q +D+     ITPK++E+ +++E  LY SL++ +  K EE+  +I E LN MK  L D AA   ++E F+D       + V  +  K     ++E + S++N A+A KL+ S+D LR ++VGTLER + SL K ++ +I+ T   LK IL+  Y + +   + S+    L E++KQ+I R+ W   PT+   W  + + + ++S+S  KL   + +Q    L  SHE F  S+++LE     R     ++  ++++ + P+LARL LE  SL+D +L   PKL +E+GRGQYGVVY C+ WG +   A+KSVVPPDEKHW DLA+EF Y + + +H+R+  +HGSV+DYNY  GS+ A+L IM+R+ RD Y  LK GL   TRLQ++LDV+EGIRFLHSQGL+HRDIKLKNVLLD  NR K+TDLGFCKP AM+SGS+VGTPIHMAPELF  +Y+ SVD+YAFGILFWY+CS  VK+P  F+R  +K+ L+  V++G RPER P  D+ECW L+  CW  DP++RPL G ++  L
Sbjct:  187 DTIPEEDL-EVQEDSEDAAHVLAELEVTMHHA--LLQDVDIVVAPC---QGLRPAVDVLGDLVNDFLPVITYALHKDELSERDEQELQEIRKYF-SFPIFFFKVP------------KLGSE----------IIASSTRRTENERSPLHHQLMDLGYLSS----SHCNCG------------VPGQDTKAQSMLVEQSEKL-RHLSTFSHQVLQTHLVDAAKALNRVHCHCLDIFINQAFDMQRDLQITPKRLEYTRKKENELYESLMNIANRKQEEMKDMICETLNTMKGELLDDAA---NME-FKDVIVPENGEAVGTRELKCCIRQIQELIISRLNQAVANKLISSVDYLRESFVGTLERCLQSLEKSQDVSIHITSNYLKQILNAAYHVEVTFHSGSSVTRMLWEQIKQIIQRITWVNPPTITLEWKRKVAQEAIDSLSASKLAKSICSQFRTRLNSSHEAFAASLRQLEAGHSGRLENTEDLWLKVRKDHAPRLARLSLESRSLQDVLLHRKPKLGQELGRGQYGVVYLCDNWGGHFPCALKSVVPPDEKHWNDLALEFHYMRSLPKHERLVDLHGSVIDYNYGGGSSIAVLLIMERLHRDLYTGLKAGLTLETRLQIALDVVEGIRFLHSQGLVHRDIKLKNVLLDKQNRAKITDLGFCKPEAMMSGSIVGTPIHMAPELFTGKYDNSVDVYAFGILFWYICSGSVKLPEAFERCASKDHLWNNVRRGARPERLPVFDEECWQLMEACWDGDPSQRPLLGIVQPML 908          

Query:  592 VMHSSDILFEGIKVVVMPSIKQKAIEEIRAIYDSHISDLLPILIYAFEFNDLSSWDKTELEEIKLLAQDSPIFFVKVPPYEKYSRLPADYKFTKEELLAVLNPPISFAPNGRKVSNTNANDSGDMKLFGTLCQMNLISAV--NNGFFSLTRSPKLETIDLNDLKIDSDLITQFDSFFEKLTNYCHSCIQKYLVRVLTIITKFASDALKNLILQVYDLSYSSVITPKKVEFAKQQELLLYNSLISRSTEKHEEICSLIGEILNIMKQTLPDAAAVEIDLESFQDKMV-------SIKMYKSATNTVREYVASKVNSAIAEKLLQSMDVLRNTYVGTLERTVNSLGKFEEENINATEA-LKNILHFTYGLHIPIKTSSTFMSSLIEKMKQLISRLPWQPDPTLDANWVMRTSSDMLNSISEVKLTHEVINQITENLKQSHENFIISIKRLENRVEVRQNKHAEMQDRIKRLYTPKLARLYLEGMSLRDNVLFGVPKLNREIGRGQYGVVYACNTWGAYNQMAVKSVVPPDEKHWCDLAMEFFYCKQMSEHDRIATIHGSVVDYNYSYGSNPAILFIMDRMARDFYAALKQGLDWVTRLQVSLDVIEGIRFLHSQGLIHRDIKLKNVLLDYNNRGKLTDLGFCKPCAMLSGSLVGTPIHMAPELFNQEYNFSVDIYAFGILFWYVCSNKVKVPTNFDRFTNKESLFEAVKKGLRPERPPKIDQECWDLISRCWHQDPNKRPLPGEIEDQL 2802
             MH +  L + + VVV P    + +     +    ++D LP++ YA   ++LS  D+ EL+EI+      P+FF KVP                      L   I+        S+T   +S    L+  L  +  +S+   N G      +P        D K  S L+ Q +     L+ + H  +Q  LV     +       L   I Q +D+     ITPK++E+ +++E  LY SL++ +  K EE+  +I E LN MK+ L D AA   ++E F+D +V         +  K     ++E + S++N A+A KL+ S+D LR ++VGTLER + SL K ++ +++ T   LK IL+  Y + +   + S+    L E++KQ+I R+ W   P +   W  + + + + S+S  KL   + +Q    L  SHE F  S+++LE     R  K  ++  ++++ + P+LARL LE  SL+D +L   PKL +E+GRGQYGVVY C+ WG +   A+KSVVPPDEKHW DLA+EF Y + + +H+R+  +HGSV+DYNY  GS+ A+L IM+R+ RD Y  LK GL   TRLQ++LDV+EGIRFLHSQGL+HRDIKLKNVLLD  NR K+TDLGFCKP AM+SGS+VGTPIHMAPELF  +Y+ SVD+YAFGILFWY+CS  VK+P  F+R  +K+ L+  V++G RPER P  D+ECW L+  CW  DP KRPL G ++  L
Sbjct:  189 TMHHA--LLQEVDVVVAPC---QGLRPTVDVLGDLVNDFLPVITYALHKDELSERDEQELQEIRKYF-SFPVFFFKVPK---------------------LGSEITD-------SSTRRTESERSLLYRQLIDLGYLSSSHWNCG------TPG------QDTKAQSVLVEQSEKL-RHLSTFSHQVLQTRLVDAAKALNLVHCHCLDIFINQAFDMQRDLQITPKRLEYTRKKENELYESLMNIANRKQEEMKDMIVETLNTMKEELLDDAA---NME-FKDVIVPENGEPVGTREIKCCIRQIQELIISRLNQAVANKLISSVDYLRESFVGTLERCLQSLEKSQDVSVHITSNYLKQILNAAYHVEVTFHSGSSVTRMLWEQIKQIIQRITWVSPPAITLEWKRKVAQEAIESLSASKLAKSICSQFRTRLNSSHEAFAASLRQLEAGHSGRLEKTEDLWLKVRKDHAPRLARLSLESRSLQDVLLHRKPKLGQELGRGQYGVVYLCDNWGGHFPCALKSVVPPDEKHWNDLALEFHYMRSLPKHERLVDLHGSVIDYNYGGGSSIAVLLIMERLHRDLYTGLKAGLTLETRLQIALDVVEGIRFLHSQGLVHRDIKLKNVLLDKQNRAKITDLGFCKPEAMMSGSIVGTPIHMAPELFTGKYDNSVDVYAFGILFWYICSGSVKLPEAFERCASKDHLWNNVRRGARPERLPVFDEECWQLMEACWDGDPLKRPLLGIVQPML 884          

Query:  307 LIIMGQTHYTKSVIVNEIFKKRIMPIKYDQP-NAPWKMIKFHYG-----IKTITSLCEF-DNAFDLGDRTNLLNKQDCINEEVLIDNAAKSDDEAFENSYVDVMHSSDILFEGIKVVVMPSIKQKAIEEIRAIYDSHISDLLPILIYAFEFNDLSSWDKTELEEIKLLAQDSPIFFVKVPPYEKYSRLPADYKFTKEELLAVLNPPISFAPNGRKVSNTNANDSG---DMKLFGTLCQMNLISAVNNGFFSL--TRSPKLETIDLNDLKIDSDLITQFDSFFEKLTNYCHSCIQKYLVRVLTIITKFASDALKNLILQVYDLSYSSVITPKKVEFAKQQELLLYNSLISRSTEKHEEICSLIGEILNIMKQTLPDAAA----VEIDLESFQDKMVSIKMYKSATNTVREYVASKVNSAIAEKLLQSMDVLRNTYVGTLERTVNSLGKFEEEN---INATEALKNILHFTYGLHIPIKTSSTFMSSLIEKMKQLISRLPWQPDPTLDANWVMRTSSDMLNSISEVKLTHEVINQITENLKQSHENFIISIKRLENRVEVRQNKHAEMQDRIKRLYTPKLARLYLEGMSLRDNVLFGVPKLNREIGRGQYGVVYACNTWGAYNQMAVKSVVPPDEKHWCDLAMEFFYCKQMSEHDRIATIHGSVVDYNYSYGSNPAILFIMDRMARDFYAALKQGLDWVTRLQVSLDVIEGIRFLHSQGLIHRDIKLKNVLLDYNNRGKLTDLGFCKPCAMLSGSLVGTPIHMAPELFNQEYNFSVDIYAFGILFWYVCSNKVKVPTNFDRFTNKESLFEAVKKGLRPERPPKIDQECWDLISRCWHQDPNKRPLPGEIEDQL 2802
             II+GQT Y K+ +VNE+F + ++P   D+  +  W+M +F YG      ++I    E  DN  D       +  QD     VL D+ A+          V++ H  ++L + ++V++ P+    ++ E+ A+Y     D+LPI++YA   + L+  D  EL+E+     + P+FFV+VPP      LP D       +  V   P +   N     N+  N +     + LF  LC +  +S +      +  T S    +     + ++S+L+  FD F   L  Y    +++ LV V  ++ +     LK +I+  +D+    ++TP+++EFA+++E  LYNSL+  + +K +EI ++I E +  MK+ L   AA    + +D+ S   ++ + +  K  T  V E +   +N+AIA KL++S+D+LR++Y GTL R + SL K + +N    + TEALK I++  Y + I I+TSS+F+  L+EKMKQLI  +PW+  P +D NW  + + DM+ S+SE +L   +  Q  E LK SHE F  ++K+LE +   R  K  E + ++++++ PK+A+L LE +S++D + FG+P+L REIGRGQYGVVY+C  W   +  A+KSVVPPDEKHW DLA+EFFY K + EH R+A + GSV+DY+Y  GS+PA+  IMDRM RD YAA+K GLDW +RLQV++DV+EG+RFLHSQGL+HRDIKLKNVL+D  NRGK+TDLGFCKP AM+SGS+VGTPIHMAPELF+  Y+ SVD+YAFGILFWYVC+  V++P  F++ T+K+ L+ +VKKG+RPE+ P  D+ECW+L+  CW  D NKRPL G++E QL
Sbjct:   70 FIILGQTCYAKASVVNEVFNQTVLPPIDDEDFDTKWRMARFKYGEQRTISRSIPGSYELVDNLTDNYHSWRTIPSQDL----VLRDSEAREPVGTLPCLEVNLKH--NVLKDDVQVILSPTNCSASLSEMVALYKE---DVLPIVMYAIGADQLTEKDLEELKELHEAEPELPVFFVRVPP-----PLPLDLTDGPSRVNGV--GPTNDYRNSNSKRNSKRNSAEYKIGLNLFQQLCDIGFLSMLPTSTEQVLQTLSSSTSSGSGEHVIMESELLENFDQFTPSLVQYTQRVLRQMLVAVAGVMNQIHGRCLKMIIMTAFDMQRDMMVTPRRLEFAREKECELYNSLMDIAMKKQDEIKTIIAETVQDMKEKLVAKAAEYDFIGVDI-SDSAEIRTARDLKICTGQVEELLLGALNNAIAGKLVESVDILRDSYTGTLTRCLESLEKADRDNNEHASTTEALKQIINAAYQVEITIRTSSSFVRILLEKMKQLIQSMPWKTPPRVDENWRKKMAQDMIKSLSEARLAKSICAQFKERLKNSHEQFSAALKQLEAKHSGRLEKTEEQRLKVRKIHAPKVAKLALESISMKDFISFGMPQLGREIGRGQYGVVYSCENWAGIHNCAIKSVVPPDEKHWNDLALEFFYTKNVPEHPRVAGLRGSVIDYSYGGGSSPAVYLIMDRMHRDLYAAIKTGLDWQSRLQVAIDVVEGMRFLHSQGLVHRDIKLKNVLMDKQNRGKITDLGFCKPEAMMSGSIVGTPIHMAPELFSGRYDNSVDVYAFGILFWYVCAGHVRLPFAFEQCTSKDQLWMSVKKGMRPEKLPHFDEECWELMQACWAGDQNKRPLLGDVEPQL 903          

Query:  286 LTDKDLSLIIMGQTHYTKSVIVNEIFKKRIMPIKYDQPNA--PWKMIKFHYGIKTITSLCEFDNAFDL-GDRTNLLNKQDCINEEVLIDNAAKSDDEAFENSYVDVMHSSDILFEGIKVVVMPSIKQKAIEEIRAIYDSHISDLLPILIYAFEFNDLSSWDKTELEEIKLLAQDSPIFFVKVPPYEKYSRLPADYKFTKEELLAVLNPPISFAPNGRKVSNTNANDSGDM--------KLFGTLCQMNLISAVNNGFFSLTRSPKLETIDLNDLK-------IDSDLITQFDSFFEKLTNYCHSCIQKYLVRVLTIITKFASDALKNLILQVYDLSYSSVITPKKVEFAKQQELLLYNSLISRSTEKHEEICSLIGEILNIMKQTLPDAAAVEIDLESFQDKMVSIKMY----KSATNTVREYVASKVNSAIAEKLLQSMDVLRNTYVGTLERTVNSLGKFE----------------------------EENINATEALKNILHFTYGLHIPIKTSSTFMSSLIEKMKQLISRLPWQPDPTLDANWVMRTSSDMLNSISEVKLTHEVINQITENLKQSHENFIISIKRLENRVEVRQNKHAEMQDRIKRLYTPKLARLYLEGMSLRDNVLFGVPKLNREIGRGQYGVVYACNTWGAYNQMAVKSVVPPDEKHWCDLAMEFFYCKQMSEHDRIATIHGSVVDYNYSYGSNPAILFIMDRMARDFYAALKQGLDWVTRLQVSLDVIEGIRFLHSQGLIHRDIKLKNVLLDYNNRGKLTDLGFCKPCAMLSGSLVGTPIHMAPELFNQEYNFSVDIYAFGILFWYVCSNKVKVPTNFDRFTNKESLFEAVKKGLRPERPPKIDQECWDLISRCWHQDPNKRPLPGEIEDQLLLMKTKA 2823
            L ++ ++++++GQT Y K+V+VNEI ++ ++P+  D  +    W+MI+F +  K   SL   D+ +DL  D +      D I E+ LI  A +  D A   + ++V  +  +L +G  +VV P    K +  +  ++        PIL+YA E + L+S D +EL++ + LA + P+FF++VP    Y    A+Y+  + +                  +   A+ +GD+        +LF  LC++  +S +  G  S    P       +          + S+L+  F++ F ++  Y    +Q+ LV+  T++       L N IL  +DL+   ++TPKK+ FAK +EL LYNSL+  S+ K EEI  LI   L  M++ L  AA      E+FQ +    + +    +  +  +RE V +K+NSAI+++LLQS+DV R+ Y GTL R + SL   E                                +ATEAL+ I++  Y + I +KT ST++ +L++K+K+L++ +PW   P LD+ W    + +ML ++S+ +L   +  QI+E ++ +HE F  +++RLE R+        + +D I+R + P++ARL LE +S+RD +++G+P++ REIGRGQYGVVY+C  WG ++ +AVKSVVPPD+KHW DLA+EF+Y K + EHDRIA + GSV+DY  +YGS PA+L IM+R+ RD +AA+KQ L+W  RLQV+ DV+EGIRFLHSQGL+HRDIKLKNVLLD  NR KLTDLGFCKP AM+SGS+VGTPIHM PELF+  Y+ SVD+YAFGILFWY+C+  V++P NF++ T K+ L+ +VK+G+RPER P    ECW L+  CW  D   RPLPG +  QL  M  +A
Sbjct:   70 LLNQPVAMVVLGQTRYAKAVLVNEILRQDLLPVATDSDSVYNGWRMIRFRFAAKPAVSLSLPDDNYDLMEDLSAYQQPWDTIPEQDLILQAEERTDLANRAAVMEVALNHPLLRDGAILVVSPC---KELCNVAEVFSQCTRGAQPILVYAIELDHLTSSDLSELQQHRQLAPNLPLFFIRVPQPAAY----ANYRQQRRQFACPPP-------VPPSAAAAAASGTGDLLQQPQAAPRLFADLCELGFLSMMPGGG-SRGGHPAGSAASSSASPADAACQPLASELVENFEANFCRILIYVRRALQQILVQAATLLNDNHCAVLNNFILLAFDLARDVLVTPKKLRFAKSKELELYNSLMEISSRKQEEIRQLIAFTLENMRECLLLAA------EAFQFRYDPAQSHGANARRCSVQIRELVMAKLNSAISDQLLQSIDVFRDAYTGTLTRCLESLEDEEAPQDLPAAAAAAASPATLADVPGGVGPSSSGASATEALRLIVNAAYQVEINVKTGSTYVRALLDKIKELMTSMPWSSPPKLDSEWRRAVAQEMLGNLSDQRLARHMCGQISERVRAAHEAFTAAMRRLEERLSAHTAACEDQRDLIRRRHAPRIARLALESISIRDMIVYGMPQIGREIGRGQYGVVYSCEAWGGFSPVAVKSVVPPDDKHWNDLALEFYYTKHLPEHDRIAHLRGSVIDY--TYGSGPAVLLIMERLTRDLHAAIKQNLNWPGRLQVACDVVEGIRFLHSQGLVHRDIKLKNVLLDRRNRAKLTDLGFCKPHAMMSGSIVGTPIHMPPELFSGVYDSSVDVYAFGILFWYLCAGTVRLPYNFEQCTTKDVLWTSVKRGVRPERLPCFSDECWQLMKLCWAADSELRPLPGALLPQLQSMLAEA 942          

Query:  286 LTDKDLSLIIMGQTHYTKSVIVNEIFKKRIMPIKYDQPNA--PWKMIKFHYGIKTITSLCEFDNAFDL-GDRTNLLNKQDCINEEVLIDNAAKSDDEAFENSYVDVMHSSDILFEGIKVVVMPSIKQKAIEEIRAIYDSHISDLLPILIYAFEFNDLSSWDKTELEEIKLLAQDSPIFFVKVPPYEKYSRLPADYKFTKEELLAVLNPPISFAPNGRKVSNTNANDSGDM--------KLFGTLCQMNLISAVNNGFFSLTRSPKLETIDLNDLK-------IDSDLITQFDSFFEKLTNYCHSCIQKYLVRVLTIITKFASDALKNLILQVYDLSYSSVITPKKVEFAKQQELLLYNSLISRSTEKHEEICSLIGEILNIMKQTLPDAAAVEIDLESFQDKMVSIKMY----KSATNTVREYVASKVNSAIAEKLLQSMDVLRNTYVGTLERTVNSLGKFE----------------------------EENINATEALKNILHFTYGLHIPIKTSSTFMSSLIEKMKQLISRLPWQPDPTLDANWVMRTSSDMLNSISEVKLTHEVINQITENLKQSHENFIISIKRLENRVEVRQNKHAEMQDRIKRLYTPKLARLYLEGMSLRDNVLFGVPKLNREIGRGQYGVVYACNTWGAYNQMAVKSVVPPDEKHWCDLAMEFFYCKQMSEHDRIATIHGSVVDYNYSYGSNPAILFIMDRMARDFYAALKQGLDWVTRLQVSLDVIEGIRFLHSQGLIHRDIKLKNVLLDYNNRGKLTDLGFCKPCAMLSGSLVGTPIHMAPELFNQEYNFSVDIYAFGILFWYVCSNKVKVPTNFDRFTNKESLFEAVKKGLRPERPPKIDQECWDLISRCWHQDPNKRPLPGEIEDQLLLMKTKA 2823
            L ++ ++++++GQT Y K+V+VNEI ++ ++P+  D  +    W+MI+F +  K   SL   D+ +DL  D +      D I E+ LI  A +  D A   + ++V  +  +L +G  +VV P    K +  +  ++        PIL+YA E + L+S D +EL++ + LA + P+FF++VP    Y    A+Y+  + +                  +   A+ +GD+        +LF  LC++  +S +  G  S    P   T   +          + S+L+  F++ F ++  Y    +Q+ LV+  T++       L N IL  +DL+   ++TPKK+ FAK +EL LYNSL+  S+ K EEI  LI   L  M++ L  AA      E+FQ +    + +    +  +  +RE V +K+NSAI+++LLQS+DV R+ Y GTL R + SL   E                                +ATEAL+ I++  Y + I +KT ST++ +L++K+K+L++ +PW   P LD+ W    + +ML ++S+ +L   +  QI+E ++ +HE F  +++RLE R+        + +D I+R + P++ARL LE +S+RD +++G+P++ REIGRGQYGVVY+C  WG ++ +AVKSVVPPD+KHW DLA+EF+Y K + EHDRIA + GSV+DY  +YGS PA+L IM+R+ RD +AA+KQ L+W  RLQV+ DV+EGIRFLHSQGL+HRDIKLKNVLLD  NR KLTDLGFCKP AM+SGS+VGTPIHM PELF+  Y+ SVD+YAFGILFWY+C+  V++P NF++ T K+ L+ +VK+G+RPER P    ECW L+  CW  D   RPLPG +  QL  M  +A
Sbjct:   70 LLNQPVAMVVLGQTRYAKAVLVNEILRQDLLPVATDSDSVYNGWRMIRFRFAAKPAVSLSLPDDNYDLMEDLSAYQQPWDTIPEQDLILQAEERTDLANRAAVMEVALNHPLLRDGAILVVSPC---KELCNVAEVFSQCTRGAQPILVYAIELDHLTSSDLSELQQHRQLAPNLPLFFIRVPQPAAY----ANYRQQRRQFACPPP-------VPPSAAAAAASGTGDLLQQPQAAPRLFADLCELGFLSMMPGGG-SRGGHPAGSTASSSASPADAACQPLASELVENFEANFCRILIYVRRALQQILVQAATLLNDNHCAVLNNFILLAFDLARDVLVTPKKLRFAKSKELELYNSLMEISSRKQEEIRQLIAFTLENMRECLLLAA------EAFQFRYDPAQSHGANARRCSVQIRELVMAKLNSAISDQLLQSIDVFRDAYTGTLTRCLESLEDEEAPQDLPAAAAAAASPATLADVPGGVGPSSSGASATEALRLIVNAAYQVEINVKTGSTYVRALLDKIKELMTSMPWSSPPKLDSEWRRAVAQEMLGNLSDQRLARHMCGQISERVRAAHEAFTAAMRRLEERLSAHTAACEDQRDLIRRRHAPRIARLALESISIRDMIVYGMPQIGREIGRGQYGVVYSCEAWGGFSPVAVKSVVPPDDKHWNDLALEFYYTKHLPEHDRIAHLRGSVIDY--TYGSGPAVLLIMERLTRDLHAAIKQNLNWPGRLQVACDVVEGIRFLHSQGLVHRDIKLKNVLLDRRNRAKLTDLGFCKPHAMMSGSIVGTPIHMPPELFSGVYDSSVDVYAFGILFWYLCAGTVRLPYNFEQCTTKDVLWTSVKRGVRPERLPCFSDECWQLMKLCWAADSELRPLPGALLPQLQSMLAEA 942          

Query:  250 QIPMEIDNETRFLTDKDLSLIIMGQTHYTKSVIVNEIFKKRIMPIK-----YDQPNAPWKMIKFHYGIKTITSLCEFDNAFDLGDRTNLLNKQ-DCINEEVLIDNAAKSDDEAFENSYVDVMHSSDILFEGIKVVVMPSIKQKAIEEIRAIYDSHISDLLPILIYAFEFNDLSSWDKTELEEIKLLAQDSPIFFVKV-PPYEK-------------YSRL----PADYKFTKEELLAVLNPPISFAPNGRKVSNTNANDSGDMKLFGTLCQMNLISAVNNGFFSLTRSPKLETIDLNDLKIDSDLITQFDSFFEKLTNYCHSCIQKYLVRVLTIITKFASDALKNLILQVYDLSYSSVITPKKVEFAKQQELLLYNSLISRSTEKHEEICSLIGEILNIMK-QTLPDAAAVEID-LESFQDKMVSIKMYKSATNTVREYVASKVNSAIAEKLLQSMDVLRNTYVGTLERTVNSLGKFEE--ENINATEALKNILHFTYGLHIPIKTSSTFMSSLIEKMKQLISRLPWQPDPTLDANWVMRTSSDMLNSISEVKLTHEVINQITENLKQSHENFIISIKRLENRVEVRQNKHAEMQDRIKRLYTPKLARLYLEGMSLRDNVLFGVPKLNREIGRGQYGVVYACNTWGAYNQMAVKSVVPPDEKHWCDLAMEFFYCKQMSEHDRIATIHGSVVDYNYSYGSNPAILFIMDRMARDFYAALKQGLDWVTRLQVSLDVIEGIRFLHSQGLIHRDIKLKNVLLDYNNRGKLTDLGFCKPCAMLSGSLVGTPIHMAPELFNQEYNFSVDIYAFGILFWYVCSNKVKVPTNFDRFTNKESLFEAVKKGLRPERPPKIDQECWDLISRCWHQDPNKRPLPGEIEDQLL 2805
            Q+ +E +     +    + + I+G   + K+ + NE+F ++I+P +      D     W+M++F YG++T  SL    N+++L D      +Q   +  E L       +D AFE + +DV     +L + + V+V P+    + E+I ++    +     I+IYA     LS  + +EL EIK      PIFF+ V PP  +             Y R     P  Y  +   L  VL          RK S  +   S  + L   LC +  ++      FS     KL       ++++S LI  F++F   L  +    +Q  LV+V TI+ +  +  L+  IL  +D+++  +ITPK++ +A+Q+E  LY SL+S +  K EEI  LI E +N M  + L  A+  E   +E   D+  S++  +  T+ ++  V   +NSA+A KL+ S+D LR ++VGTLER + SL   +E  E   A+ ALK IL+  Y + + ++TSS+ +  L EKMKQL+  LPW+  P +D  W  + + DML S+SE +L   + +Q  E L+ SHE F  S++ LE     R  +  E + ++++L+ PKLA+  LE  SLRD +L+G+P + REIGRGQYGVVYAC++W  Y+  A+KSVVPPD+KHW DLAMEF+Y + + EHDRI  I GSV+D  Y+ GS PA+L +MDR+ RD Y+ALK GL W TRLQ++LDV++GIRFLH QGL+HRDIKLKNVLLD +NR K+TDLGFCKP AM+SGS+VGTPIHMAPELF+  Y+ SVD+YAFGILFWY+C++ V++P  +++  +K+ L+ +VKKG RPER P+ D+ CW L+  CW+ +P+ RPL GE+E +L+
Sbjct:   48 QLKLENEQTVYGVIYSSIGITILGHDCWAKAAVANELFGQKILPTEPQDAESDSSKMAWRMVRFIYGVETQVSLA-LPNSYELLDHLVSHEQQWHTVPLEDLELKGKPGEDPAFETAVLDVKLRHQLLRDDVVVMVSPTNVNASFEQILSVC---MDGFTSIVIYAISNGVLSQSEVSELMEIKKKFPKLPIFFICVFPPSSELTESEQHVRNIGLYGRRSVFKPHSYHESSPMLQTVLK---------RKESLDSKLGSASLTLCQQLCGLGFLNV-----FSPNLKKKLCRQPSGGIEVESKLIEDFENFSSILL-HIRQILQAELVQVATILNEAHNTCLRMFILSAFDMTWDMLITPKRIAYARQRENELYESLMSIANCKQEEIRQLIVETINAMTDELLLKASEYEFQGVELSDDEPPSVRELQICTSEIQSLVLHSLNSAVAGKLIGSVDYLRESFVGTLERCLVSLENVKEGSEPSQASNALKQILNAAYQVEVTVRTSSSLLRVLFEKMKQLVQTLPWKAPPVIDCEWKRKVAYDMLMSLSESRLARSICSQFRERLRASHEQFAASLRHLEAMHSGRLERTEEQRLKVRKLHAPKLAKFALESTSLRDIILYGMPHIGREIGRGQYGVVYACDSWAGYSPCAIKSVVPPDDKHWNDLAMEFYYTRSIPEHDRIVQIRGSVIDLTYAGGSTPAVLLVMDRLQRDLYSALKMGLPWKTRLQLALDVVQGIRFLHGQGLVHRDIKLKNVLLDKHNRAKITDLGFCKPEAMMSGSIVGTPIHMAPELFSGRYDNSVDVYAFGILFWYICADHVRLPYVYEQCQSKDQLWTSVKKGARPERLPQFDENCWRLMEDCWNGNPSLRPLLGEVEPRLM 908          

Query:  304 SLIIMGQTHYTKSVIVNEIFKKRIMP-IKYDQPNAPWKMIKFHYGIKTITSLCEFDNAFDLGDRTNLLNKQ-DCINEEVLIDNAAKSDDEAFENSYVDVMHSSDILFEGIKVVVMPSIKQKAIEEIRAIYDSHISDLLPILIYAFEFNDLSSWDKTELEEIKLLAQDSPIFFVKVPPYEKYSR-----LPADYKFTKEELLAVLN--------------------PPISFAPNGRKVSNTNANDSGDMKL-------FGTLCQMNLISAVNNGFFSLTRSPKLETIDLNDLKIDSDLITQFDSFFEKLTNYCHSCIQKYLVRVLTIITKFASDALKNLILQVYDLSYSSVITPKKVEFAKQQELLLYNSLISRSTEKHEEICSLIGEILNIMKQTLPDAAA----VEIDLESFQDKMVSIKMYKSATNTVREYVASKVNSAIAEKLLQSMDVLRNTYVGTLERTVNSLGKFEEENINA------TEALKNILHFTYGLHIPIKTSSTFMSSLIEKMKQLISRLPWQPDPTLDANWVMRTSSDMLNSISEVKLTHEVINQITENLKQSHENFIISIKRLENRVEVRQNKHAEMQDRIKRLYTPKLARLYLEGMSLRDNVLFGVPKLNREIGRGQYGVVYACNTWGAYNQMAVKSVVPPDEKHWCDLAMEFFYCKQMSEHDRIATIHGSVVDYNYSYGSNPAILFIMDRMARDFYAALKQGLDWVTRLQVSLDVIEGIRFLHSQGLIHRDIKLKNVLLDYNNRGKLTDLGFCKPCAMLSGSLVGTPIHMAPELFNQEYNFSVDIYAFGILFWYVCSNKVKVPTNFDRFTNKESLFEAVKKGLRPERPPKIDQECWDLISRCWHQDPNKRPLPGEIEDQL 2802
             ++I GQ  Y KS +VNEIF + I P  +    N   +M++F YG      L    + +DL +      +    I  E +  +   S D A   + ++V  +  +L  G KV+V PS+      ++   Y      + PIL++AF+  +L+  D + L++++ ++   P+ FV V   +  S         +   +K++L A  N                    P    +P    +S+  +  +   ++       F  LC +  +S  + G  +LT      T+  +  ++DS+LI  F SF  ++  +    IQ+YLV   T++      +L   I+  +D++   +ITPKK+EFA+ +E  LY SL+  S EK +EI  +I E +  + Q+L D AA    + +D +  Q  +++ K  K  T  ++E V   +N AIA  L++S+DVLR+TY GTL R + SL +F+ ++  +      +EALK IL+  Y + I +++SS+F+ +++E+MKQL+  +PW   P +D  W  + ++D+L ++SE +L   + +QI E L +SH+ F I++++LE +   R +K  + + ++++++ P++A++ LE  SL+D +L G P+++REIGRGQYGVVY+C++W  +   A+KSVVPPD+KHW DLA+EF+Y K +  H+RI  + GSV+DY Y  G++PA+L IMDR+ RD YAA+KQGLDWV+RLQVS+DV+EGIRFLHSQGL+HRDIKLKNVLLD +NRGK+TDLGFCKP AM+SGS+VGTPIHMAPELF+  Y+ SVD+YAFGILFWYVC+  VK+P+ F++  NK+ L+ +VKKGLRPE+    D +CW+L+  CW  +P KRPL G +E +L
Sbjct:   65 GIVIFGQNAYCKSCVVNEIFSRNIFPRFENGDINGNNRMVQFKYGSNLSVGL-SLPDGYDLAENLEAYKRPWSTIPIEDIEISENPSLDGANGTAVLEVSINHSMLRHGAKVIVSPSMNDSG-SDLEQKYSKCCEKVSPILLFAFQTQELTENDLSFLKKLQTISHYQPVCFVGVSTEKSDSSDGSRTTEKNLNASKQKLEAGCNGSIEDLDDHENQNHLTNIDEPNYCVSPMSSPLSSVCSKGTCKGRVILTSSLVFHQLCDIGYLSE-SPGSRNLT-----NTMATDYYEVDSELIDNFASFPSRIVYFVQQTIQRYLVNAATVLNNCHERSLNMFIVSAFDMARDMMITPKKLEFARGKETELYKSLMKISVEKGDEIKLMISETIQSIHQSLVDKAAQYEFLGVDFDE-QSVILTTKGLKICTYQIQELVLGALNQAIAGNLVRSVDVLRDTYTGTLSRCLESLERFDVDHGQSANSKSTSEALKQILNAAYQVEISLQSSSSFIRNILERMKQLVKAMPWSTPPRIDEEWKKKAAADILANLSEARLAKSISSQIKERLNKSHDAFAIALRQLEQKHSGRLDKIEDERLKLRKVHAPRVAKVALESTSLKDVILHGTPQMSREIGRGQYGVVYSCDSWSGFAPCAIKSVVPPDDKHWNDLALEFYYTKNIPPHERIVVLRGSVIDYMYGGGTSPAVLLIMDRLQRDLYAAIKQGLDWVSRLQVSIDVVEGIRFLHSQGLVHRDIKLKNVLLDKDNRGKITDLGFCKPEAMMSGSIVGTPIHMAPELFSGRYDNSVDVYAFGILFWYVCAGHVKLPSAFEKCDNKDHLWTSVKKGLRPEKHLTFDADCWNLMVECWEGEPLKRPLLGNVETRL 932          

Query: 1216 ILQVYDLSYSSVITPKKVEFAKQQELLLYNSLISRSTEKHEEICSLIGEILNIMK-QTLPDAAAVEID--LESFQDKMVSIKMYKSATNTVREYVASKVNSAIAEKLLQSMDVLRNTYVGTLERTVNSLGKFEEE----NINATEALKNILHFTYGLHIPIKTSSTFMSSLIEKMKQLISRLPWQPDPTLDANWVMRTSSDMLNSISEVKLTHEVINQITENLKQSHENFIISIKRLENRVEVRQNKHAEMQDRIKRLYTPKLARLYLEGMSLRDNVLFGVPKLNREIGRGQYGVVYACNTWGAYNQMAVKSVVPPDEKHWCDLAMEFFYCKQMSEHDRIATIHGSVVDYNYSYGSNPAILFIMDRMARDFYAALKQGLDWVTRLQVSLDVIEGIRFLHSQGLIHRDIKLKNVLLDYNNRGKLTDLGFCKPCAMLSGSLVGTPIHMAPELFNQEYNFSVDIYAFGILFWYVCSNKVKVPTNFDRFTNKESLFEAVKKGLRPERPPKIDQECWDLISRCWHQDPNKRPLPGEIEDQL 2802
            I Q +D+     ITP+++E+ +++E  L+ SL++ +  K EE+  +I E L+ MK Q L DAA +E    + +   + V+ K  KS    ++E +  ++N A+A KL+ S+D LR ++VGTLER ++SL K   +    N+ +   LK IL+  Y + +   + S+    + E++KQ+I RL W   P +   W  + + D + S+S  KL   + +Q    L  SH+ F  S+++LE     R  +  ++  R+++ + P+LARL LE  SLRD +L+G PKL RE+GRGQYGVVY C+ WG  N  A+KSVVPPD+KHW DLA+EF Y + + +H+R+  +HGSV+D+ Y  GS+ A+L IM+R+ RD Y  LK GL    RLQ++LDV+EGIRFLH QGL+HRDIKLKNVLLD  NR K+TDLGFCKP AM+SGS+VGTPIHMAPELF                                              G RPER P  D+ECW L+  CW+ DP +RPL G ++  L
Sbjct:  354 INQAFDMQRDLQITPRRLEYTREKESELFASLMAIANRKQEEMKEMIVETLSTMKEQLLEDAANLEFTDIIVTPNGEPVTTKEIKSCIQQIQELIVVRLNQAVANKLISSVDYLRESFVGTLERCLSSLEKSTTDSSVHNVTSNH-LKQILNAAYHVEVTFHSGSSVTRLVWEQIKQIIQRLTWVNPPAITPEWKRKVAQDAIESLSAAKLAKSICSQFRTRLNSSHDAFAASLRQLEEGHTGRLERTEDLWLRVRKDHAPRLARLSLESRSLRDVLLYGKPKLGRELGRGQYGVVYLCDKWGEQNPCALKSVVPPDDKHWNDLALEFHYTRSLPKHERLVNLHGSVIDHTYGGGSSIAVLLIMERLHRDLYTGLKAGLSLKERLQIALDVVEGIRFLHGQGLLHRDIKLKNVLLDKQNRAKITDLGFCKPEAMMSGSIVGTPIHMAPELFT---------------------------------------------GSRPERLPTFDEECWQLMEACWNGDPLQRPLLGIVQPSL 843          

Query: 2251 SYGSNPAILFIMDRMARD---FYAALKQGLDWVTRLQVSLDVIEGIRFLHSQGLIHRDIKLKNVLLDYNNRGKLTDLGFCKPCAM---LSGSLVGTPIHMAPE-LFNQEYNFSVDIYAFGILFWYVCSNKVKVPTNFDRFTNKESLFEAVKKGLRPERPPKIDQECWDLISRCWHQDPNKR 2772
            ++ S   + F+M+ +      F+   K   D       S ++I G++FLHS+G+I+RD+KL NV+LD +   K+ D G CK   +    + +  GTP ++APE L  Q+Y FSVD ++FG+L + +     + P   D   +++ LFE+++  + P  P  I +E  DL+ + + +DP +R
Sbjct:  393 TFQSKEHLFFVMEYLNGGDLMFHIQDKGRFDLFRATFYSAEIICGLQFLHSKGVIYRDLKLDNVMLDKDGHIKIADFGMCKENMIGENRATTFCGTPDYIAPEILLGQKYTFSVDWWSFGVLVYEMLIG--QSPFQGD---DEDELFESIRMDV-PHYPRWITKESKDLLEKLFERDPTRR 567          

Query: 2251 SYGSNPAILFIMDRMARD---FYAALKQGLDWVTRLQVSLDVIEGIRFLHSQGLIHRDIKLKNVLLDYNNRGKLTDLGFCKPCAM---LSGSLVGTPIHMAPE-LFNQEYNFSVDIYAFGILFWYVCSNKVKVPTNFDRFTNKESLFEAVKKGLRPERPPKIDQECWDLISRCWHQDPNKR 2772
            ++ S   + F+M+ +      F+   K   D       S ++I G++FLHS+G+I+RD+KL NV+LD +   K+ D G CK   +    + +  GTP ++APE L  Q+Y FSVD ++FG+L + +     + P   D   +++ LFE+++  + P  P  I +E  DL+ + + +DP +R
Sbjct:  429 TFQSKEHLFFVMEYLNGGDLMFHIQDKGRFDLFRATFYSAEIICGLQFLHSKGVIYRDLKLDNVMLDKDGHIKIADFGMCKENMIGENRATTFCGTPDYIAPEILLGQKYTFSVDWWSFGVLVYEMLIG--QSPFQGD---DEDELFESIRMDV-PHYPRWITKESKDLLEKLFERDPTRR 603          

Query: 2056 IGRGQYGVVYACNTWGAYNQMAVKSVVPPDEKHWCDLAMEFFYCKQMSEHDRIATIHGSVVDYNYSYGSNPAILFIMDRMARDFYAALKQG----LDWVTRLQVSLDVIEGIRFLHSQGLIHRDIKLKNVLLD-YNNRGKLTDLGFCK------PCAMLSGSLVGTPIHMAPELFNQ---EYNFSVDIYAFGILFWYVCSNKVKVPTNFDRFTNKESLFEAVKKGLRPERPPKIDQECWDLISRCWHQDPNKRPLPGEIEDQLLL 2808
            +GRG YGVVYA        ++A+K +   D ++   L  E    K + + +        +V Y  S   +  I   M+++     +AL +     L   T +  +  ++EG+R+LH   ++HRDIK  NVL++ Y+   K++D G  K      PC   + +  GT  +MAPE+ ++    Y    DI++ G     + + K   P   +    + ++F+     + PE P  +  E    I RC+  DPNKR   G++   L +
Sbjct:  647 LGRGTYGVVYAGRDLSNQVRIAIKEIPERDSRYSQPLHEEIALHKYLKQRN--------IVQYLGSVSEDGYIKIFMEQVPGGSLSALLRSKWGPLKEATIIFYTRQILEGLRYLHENQIVHRDIKGDNVLVNTYSGVLKISDFGTSKRLAGVNPC---TETFTGTLQYMAPEIIDKGPRGYGAPADIWSLGCTIIEMATGK---PPFHELGEPQAAMFKVGMFKIHPEIPESLSTEAKSFILRCFEPDPNKRATAGDLLKDLFV 897          

Query: 1825 LTHEVINQITENLKQSHENFII-SIKRLENRVEVRQNKHAEMQDRIKRLYT-----PKLARLYLEGMSLRDNVLFGVPKLNREIGRGQYGVVYACNTWGAYNQMAVKSVVPPDEKHWCDLAMEFFYCKQMS---EHDRIATIHGSVVDYNYSYGSNPAILFIMDRMARDFYAALKQGLDWVTRLQVSLDVIEGIRFLHSQGLIHRDIKLKNVLLDYNNRGKLTDLGFCKPCAMLSGSLVGTPIHM------APELFN-QEYNFSVDIYAFGILFWYVCSNKVKVPTNFDRFTNKESLFEAVKKGLRPERPPKIDQECWDLISRCWHQDPNKRP 2775
            ++H +IN   E      EN +  +I R+   +E  Q+  A M  R++R  T     P  A  + E    R++V     +L +E+G GQ+GVV     W   +++A+K V     K  C  + +F    Q+     H ++  +HG   +    Y       F+ +    DF  +  + +     L + LDV E + +L  Q  IHRD+  +N L+D +   K++D G  +   +L      +P         APE+ N  +++   D++AFG+L W V S   K P  ++ + N + + E V +G R  RP     + + ++  CWH+ P +RP
Sbjct:  340 VSHYLINVNAEGKYYLAENHLFDTIPRM---IEYHQHNSAGMSTRLRRPATESDDTPPSA--HGEWELCREDV-----ELVKELGSGQFGVV-QLGMWKGQHEVAIKMV-----KEGCMSSDDFIDEAQIMMKLRHPKLVRLHGVCTERFPIY---IVTEFMSNGCLLDFLRSHGKEMQPPQLLNMCLDVCEAMAYLEDQQFIHRDLAARNCLVDKDLTVKVSDFGMAR--YVLDDQYTSSPGTKFPVKWSAPEVLNYTKFSSKSDVWAFGVLMWEVYSLG-KQP--YEHYDNGQ-VAEKVMQGHRLYRPQLATDQIYQVMKACWHEAPEERP 647          

Query:  307 LIIMGQTHYTKSVIVNEIFKKRIMPIKYDQPNAPWKMIKFHYGIKTITSLCEFDNAFDLGDRTNLLNKQDCINEEV----LIDNAAKSDDEAFENSYVDVMHSSDILFEGIKVVVMPSIK----QKAIEEIRAIYDSHISDLLPILIYAFEFNDLSSWDKTELEEIKLLAQD--SPIFFVKVPPYEK---------YSRLPADYKFTKEELLAVLNPPISFAPNGRKVSNTNANDSGDMKLFGTLCQMNLISAVNNGFFSLTRSPKLETIDLNDLKIDSDLITQFDSFFEKLTNYCHSCIQKYLVRVLTIITKFASDALKNLILQVYDLSYSSVITPKKVEFAKQQELLLYNSLISRSTEKHEEICSLIGEILNIM-KQTLPDAAAVEI-DLESFQDKMVSIKMYKSATNTVREYVASKVNSAIAEKLLQSMDVLRNTYVGTLERTVNSL---GKFEEENINATEALKNILHFTYGLHIPIKTSSTFMSSLIEKMKQLIS-RLPWQPDPTLDANWVMRTSSDMLNSISEVKLTHEVINQITENLKQSHENFIISIKRLENRVEVRQNKHAEMQDRIKRLYTPKLARLYLEGMSLRDNVL 2028
            L+I G +   K   +  I  +R++P       AP   + F +  K  TS+       DL         + C+   V     I  A ++D            H      + + VV+ PS +      A+EE+R       S LLP+L+YA     LS  D  EL  +K   Q+   P+FF+++PP            Y+RL   Y   + +L                   +  N  G   L   L  ++ +     G    T + +  +  L D               ++L ++    +   LV    ++    +  L   I   +D++    ITP+++++ + +E  LY SL+  + EK EEI  +I + L+ M KQ L +AA  E  D+     +  S +  +  +  ++E V +++  A+A KL+ S+D LR ++VGTL R ++SL   G     N   +  LK IL+  Y + +  ++ S+    L E++KQ+    L W   P L A W  + + D ++S+S  KL   + +Q    L  SHE F  S+++LE +   R  +  +M  R+++ + P+LARL LE  SLRD +L
Sbjct:   27 LLIAGTSDGAKLRALECILGERVLPDLPSDGTAPLSSLAFVFDAKGPTSI-------DLPHIYLRTYVRACVFRAVRSHTWIIGAGRADRTTRVTPCARPRH------QEVSVVLAPSRQLQPLTSALEELR-------SHLLPVLLYAVASERLSEADALELARLK---QNFSEPVFFLRLPPAPPAPPAPAAPPYARLTTTYAKLERDL------------------PSAGNSCGGTVLHRQLVGLDYLGGTTAG----TSAGRAHSA-LTDCA-------------DRLPHFSRLALHARLVEATGVLGGVHARGLDLFISHAFDMARDLQITPRRLQYTRAKEEELYASLLEIANEKQEEIRQMIVDTLDSMRKQLLEEAATTEFADVPVSNGEPGSGRGVQRCSKHIQELVLNRLKEAVASKLIASVDYLRESFVGTLARCLDSLEKSGGDVTSNSLTSSHLKQILNAAYHVEVTFQSGSSVAYILWEQIKQVGQVYLTWTTPPALTAEWKRKVAQDTMDSLSASKLAKNICSQFRARLNHSHEAFASSLRQLEAKHSGRLERTEDMWLRVRKDHAPRLARLSLESRSLRDILL 566          

Query: 2356 SLDVIEGIRFLHSQGLIHRDIKLKNVLLDYNNRGKLTDLGFCKP---CAMLSGSLVGTPIHMAPEL-FNQEYNFSVDIYAFGILFWYVCSNKVKVPTNFDRFTNKESLFEAVKKGLRPERPPKIDQECWDLISRCWHQDPNKR-PLPGEI 2790
            + +++ G++FLH QG+I+RD+KL N+LLD +   K+ D G CK      + +G+  GTP ++APE+   Q+YN SVD ++FG+L + +   +        R  ++E LFE+++  + P  P  I ++  D++     ++P KR  + GEI
Sbjct:   94 AAEIVSGLQFLHDQGIIYRDLKLDNILLDKDGHVKIADFGMCKENIVGDVRAGTFCGTPDYIAPEIVIGQKYNCSVDWWSFGVLLYEMLIGQSPF-----RGDDEEELFESIRTSV-PYYPRWITKDSRDILPLLLEREPMKRLGVTGEI 237          

Query: 2314 ALKQGLDWVTRLQVSLDVIEGIRFLHS--QGLIHRDIKLKNVLLDYNNRGKLTDLGFCK------PCAML-SGSLVGTPIHMAPELFNQEYNFSV--DIYAFGILFWYVCSNKVKVPTNFDRFT--------NKESLFEAVKKGLRPERPPKIDQECWDLISRCWHQDPNKRP 2775
            A+   L W  RL+V  +V  G+ FLHS    L+HRD+K  NVLLD     KL D G  K       C+ + S +  GT  +M PE F   Y  S+  D+Y++ IL W V + +       D           N+ S  E+      P R P +      L+ RCW QDP +RP
Sbjct:  111 AVYPELPWPLRLRVLHEVALGVNFLHSLEPPLLHRDLKASNVLLDEEFHVKLGDFGLAKWRQLSLACSSVHSQAGTGTVFYMPPEAFEMHYRPSIKYDVYSYAILSWEVLTRQRSFEDAVDSTQVIFSVFRGNRPSTSESALPLSTPHRAPLL-----ALVQRCWAQDPEQRP 278          

Query: 2323 QGLDWVTRLQVSLDVIEGIRFLHSQGLIHRDIKLKNVLLDYNNRGKLTDLG--FCKPCAML-----------SGSL-----VGTPIHMAPELFNQ---EYNFSVDIYAFGILFWYVCSNK-------VKVPTNFDRFTNKESLFEAVKKGLRPER---PPKIDQECWDLISRCWHQDPNKRP 2775
            + + W  R ++ L+VIEG+ ++HSQ +IH+D+K +NVL++ +   K+ D G   CK  + L           SG       +GT  +MAPE FN    + N   D+Y+F IL W + + K           T +D   N        +K  RP+    PP+       L+  CW+Q P +RP
Sbjct:  108 ENVPWCLRARIMLEVIEGMLYVHSQKIIHQDLKPENVLVNGDFHAKIADFGVSICKTWSRLGKEEQTRRNTVSGEKKKKLGMGTAAYMAPERFNNVNLQANEKTDVYSFAILTWVIITQKEPYQHLQCGDQTTYDVLKN------CTEKNQRPDMNLVPPRSPHCIIKLMESCWNQRPEERP 283          

Query: 2044 LNREIGRGQYGVVYACNTWGAYNQMAVKSVVPPDEKHWCDLAMEFFYCKQMSEHDRIATI-------HGSVVD-YNYSYGSNPAILFI--MDRMARDFYAALKQGLDWVTRL-QVSLDVIEGIRFLHSQGLIHRDIKLKNVLLDYNNRGKLTDLGFCKPC---AMLSGSLVGTPIHMA-PELF-NQEYNFSVDIYAFGILFWYVCSNKVKVPTNFDRFTNKESLFEAVKKGLRPERPPKIDQECWDLISRCWHQDPNKRP 2775
            L +E+G GQ+GVV          ++ V   V  +      +A++  +   MSE D I          H  +V  Y  S    P +L    M+    + +   ++G +  ++L Q+  DV E + +L  +  +HRD+  +N L++     K++D G  +        S S    P+  + PE+F N +++   D++AFGIL W V S  + +P  +D ++N  ++ E V+ G R  RP +  Q    ++  CWH+ P +RP
Sbjct:  311 LLQELGSGQFGVV----------RLGVWKRVRGN------VAIKMLHEATMSEDDFIEEAKTMMRLWHPKLVHFYGVSCRKRPFLLVTEYMEAGNLESFVRERRGANSASQLLQMCADVCEAMAYLERESFLHRDLAARNCLVNAQGTVKVSDFGMSRYVLDDQYTSSSGTKFPVRWSPPEVFLNNKFSSKSDVWAFGILMWEVFSEGM-LP--YDPWSNS-NVVEQVQAGYRLYRPERATQPVHLIMHSCWHERPEERP 550          

Query: 2044 LNREIGRGQYGVVYACNTWGAYNQMAVKSVVPPDEKHWCDLAMEFFYCKQMSEHDRIATIHGSVVDYNYSYGSNPAILFIMDRMARDFYAALKQGLDWVTRLQVSLDVIEGIRFLHSQGLIHRDIKLKNVLLDYNNRGKLTDLGFCKPCAMLSGSLVGTPIHMAPELF-NQEYNFSVDIYAFGILFWYVCSNKVKVPTNFDRFTNKESLFEAVKKGLRPERPPKIDQECWDLISRCWHQDPNKRPLPGEIEDQLLLMKT---KAQNLNIFNQSIISRD 2865
            L + IGRG YGVVY          +A+K VV  +++   D+  E    K ++ H+ I   HG +     SY     + +  +   R   +    GL            + G+++LH +G+IHRDIK  N+LL  +N  KL D G        + +L GT   MAPE+  N+  +   DI++ G     V     K P  +   T+    +        P  P    +   D +S+C+ ++  KRP   ++   + +  T   K   LN F +     D
Sbjct:   27 LKQVIGRGSYGVVYKAINKHTDQVVAIKEVVYENDEELNDIMAEISLLKNLN-HNNIVKYHGFI---RKSYELYILLEYCANGSLRRLISRSSTGLSENESKTYVTQTLLGLKYLHGEGVIHRDIKAANILLSADNTVKLADFGVSTIVNSSALTLAGTLNWMAPEILGNRGASTLSDIWSLGAT---VVEMLTKNPP-YHNLTDANIYYAVENDTYYP--PSSFSEPLKDFLSKCFVKNMYKRPTADQLLKHVWINSTENVKVDKLNKFKEDFTDAD 294          

Query: 2356 SLDVIEGIRFLHSQGLIHRDIKLKNVLLDYNNRGKLTDLGFCKPCAMLSGSLVGTPIHMAPELFN-QEYNFSVDIYAFGILFW--------YVCSNKVKVPTNFDRFTNKESLFEAVKKGLRPERPPKIDQECWDLISRCWHQDPNKR 2772
            + +V   + +LHS+ +I+RD+K +N+LLD N   K+TD GF K    ++ +L GTP ++APE+ + + YN S+D ++FGIL +        +  SN +K    +++  N E  F           PP  +++  DL+SR   +D ++R
Sbjct:  191 AAEVCLALEYLHSKDIIYRDLKPENILLDKNGHIKITDFGFAKYVPDVTYTLCGTPDYIAPEVVSTKPYNKSIDWWSFGILIYEMLAGYTPFYDSNTMKT---YEKILNAELRF-----------PPFFNEDVKDLLSRLITRDLSQR 324          

Query: 2356 SLDVIEGIRFLHSQGLIHRDIKLKNVLLDYNNRGKLTDLGFCKPCAMLSGSLVGTPIHMAPELF-NQEYNFSVDIYAFGILFWYVCSNKVKVPTNFDRFTNKESLFEAVKKGLRPERPPKIDQECWDLISRCWHQDPNKR 2772
            + +VI  + +LH+  +I+RD+K +N+LLD N   K+TD GF K    ++ +L GTP ++APE+   + YN SVD ++ G+L + + +        +D  T     +E + +G +   PP    +  DL+S+    D  +R
Sbjct:  174 AAEVILALEYLHAHNIIYRDLKPENILLDRNGHIKITDFGFAKEVQTVTWTLCGTPDYIAPEVITTKPYNKSVDWWSLGVLIYEMLAGYTPF---YD--TTPMKTYEKILQG-KVVYPPYFHPDVVDLLSKLITADLTRR 307          

Query: 2374 GIRFLHSQGLIHRDIKLKNVLLDYNNRGKLTDLGFCKPCAMLSG--SLVGTPIHMAPELFNQEY--NFSVDIYAFGILFWYVCSNKVKVPTNFDRFTNKESLFEAVKKGLRPERPPK-IDQECWDLISRCWHQDPNKRP 2775
             + + HS   +HRD+KL+N+LLD N   KLTD GF + C   +   ++ GT ++MAPEL  +     F +DI++ G++ + + +  +     FD     ++ ++ V +   P+   K I  +  DLISR   ++P +RP
Sbjct:  144 AVYYAHSMHCVHRDLKLENILLDKNGNAKLTDFGFTRECMTKTTLETVCGTTVYMAPELIERRTYDGFKIDIWSLGVILYTLITGYLP----FDDDDEAKTKWKIVNE--EPKYDAKVIPDDARDLISRLLAKNPGERP 276          

Query: 2053 EIGRGQYGVVYACNTWGAYNQMAVKSVVPPDEKHWCDLAMEFFYCKQMSEHDRIATIHGSVVDYNYSYGSNPAILFIMDRMARD------FYAALKQG-LDWVTRLQVSLDVIEGIRFLHSQGLIHRDIKLKNVLLDYNNRGKLTDLGFCKPCAMLS---GSLVGTPIHMAPELFN-QEYNFSVDIYAFGILF 2598
            +IG+G  G VY     G    +A+K +    +     +  E    K         + H ++V++  SY     +  IM+ M          +  L +G +  V R     + + G+ FLHS+G++HRDIK  N+LL      KLTD GFC     L+    ++VGTP  MAPE+ + +EY   VDI++ GI+ 
Sbjct:  625 KIGQGASGGVYTAYEIGTNVSVAIKQMNLEKQPKKELIINEILVMK--------GSKHPNIVNFIDSYVLKGDLWVIMEYMEGGSLTDVVTHCILTEGQIGAVCR-----ETLSGLEFLHSKGVLHRDIKSDNILLSMEGDIKLTDFGFCAQINELNLKRTTMVGTPYWMAPEVVSRKEYGPKVDIWSLGIMI 804          

Query:  241 IPTQIPMEIDNETRFLTDKDLSLIIMGQTHYTKSVIVNEIFKKRIMPIKYD-QPNAPWKMIKFHYGIKTITSLCEFDNAFDLGDRTNLLNK-QDCINEEVLIDNAAKSDDEAFENSYVDVMHSSDILFEGIKVVVMPSIKQKAIEEIRAIYDSHISDLLPILIYAFEFNDLSSWDKTELEEIKLLAQDSPIFFVKVPPYEKYSRLPADYKFTKEELLAVLNPPISFAPNGRKVSNTNANDSGDMKLFGTLCQMNLISAVNNGFFSLTRSPKLETIDLNDLK------IDSDLITQFDSFFEKLTNYCHSCIQKYLVRVLTIITKFASDALKNLILQVYDLSYSSVITPKKVEFAKQQELLLYNSLISRSTEKHEEICSLI-GEILNIMKQTLPDAAAVEI-DLE-SFQDKMVSIKMYKSATNTVREYVASKVNSAIAEKLLQSMDVLRNTYVGTLERTVNSLGKFEE-------ENINATEALKNILHFTYGLHIPIKTSSTFMSSLIEKMKQLISRLPWQPDPTLDANWVMRTSSDMLNSISEVKLTHEVINQITENLKQSHENFIISIKRLENRVEVRQNKHAEMQDRIKRLYTPKLARLYLEGMSLRDNVLFGVPKLNREIGRGQYGVVYACNTWGAYNQMAVKSVVPPDEKHWCDLAMEFFYCKQMSEHDRIATIHGSVVDYNYSYGSNPAILFIMDRMARDFYAALKQGLDWVTRLQVSLDVIEGIRFLHSQGLIHRDIKLKNVLLDYNNRGKLTDLGFCKPCAMLSGSLVGTPIHMAPELFNQEYNFSVDIYAFGILFWYVCSNKVKVPTNFDRFTNKESLFEAVKKGLRPERPPKIDQECWDLISRCWHQDPNKRPLPGEIEDQLL 2805
            + T +P +       + +K  ++I++GQT + K  ++NE+  + ++P   D + +  W+MI+  YG  +  SL    ++F+L    N       C+    L  N  +  D A  ++  ++  +  +L  G ++V  PS  +   E I   + +   D+LPIL+Y+ E + LS  D+ EL +IK LA D PIFFVK       SR   D          + N    +A +        A      ++F    Q+  I  +        ++ + E +D+ + K      I   ++ +  S F     +    +Q +LV   T++      AL   I   +D++   +ITP+++E+AK++E  L+ +L+  +T K EEI  +I   I N+  Q L +  ++E   +E S + K+++ K     T  ++E V  ++N A+A  ++ S++ LR ++VGTL+R ++SL K +        E  +AT ALK+++   Y + +  + SS+    L EKMKQ I  LP +  P +D+ W  + + DML S+SE +L   +  Q    L +SHE+F   ++ LE     R  K  E + ++++ + PK+ARL LE  SLRD VL+G+P+L+RE+GRGQYGVVYAC+ W   +  A+KSVVPPD+KHW DLA+EFFY + +  HDR+ +I GSV+DY+Y  GS+PA+L +MDR+ RD Y  +K GL +  R+ V++DV+EGIRFLHSQGL+HRDIKLKNVLLD  NRGK+TDLGFCKP AM+SGS+VGTPIHMAPELF+  Y+ SVD+YA GIL WY+C+  V++P  F++  +K+ L+ AV++G+RPER    D+ECW L+  CW  DP+ RPL G+I+ QL+
Sbjct:   44 LATFLPADKCQSLDSVCEKPPTIIVVGQTCFAKVCVINELLGEPVLPSVEDLEGDRSWRMIRIKYGNISNVSLV-LPDSFELAAALNAYEGCWQCVPRGDLELNDEEKADPAMASAVAEISLNHALLKAGAQLVCSPSNPEGDAENI---FSACCEDVLPILVYSIEQDFLSDKDEAELLQIKALAPDLPIFFVKC------SRKKPD----------LTNSMTEYAQHEAIEEFAEAR----TRIFE---QLRKIGYLTQESPEQKKALQHEVLDIRNAKAILDSVIPKSMLIENFSLFPCFLLFVRQVLQFHLVEAATVMNDAHCRALSLFITTAFDMARDMIITPRRLEYAKEKEEELFLALMETATRKQEEIKEVIKSTIENLSPQILKEVESLEFRGVECSGEQKLLNPKDLDHCTFQIQELVLGRINKAVAGNMISSVEYLRESFVGTLQRCIDSLEKMDSDSRRNACEYTSATVALKHVIDAAYQVEVTYRASSSLARLLWEKMKQAIQTLPGKTPPKVDSAWKRKVAQDMLTSLSETRLAKHICLQFRTRLIKSHESFTSCMRMLEANHTGRLEKTEEQRMKVRKSHAPKIARLALESWSLRDVVLYGMPQLSREVGRGQYGVVYACDRWAGRHPCAIKSVVPPDDKHWNDLALEFFYTRSLPLHDRVVSIIGSVIDYSYGGGSSPAVLLVMDRLQRDLYQGIKAGLSFRARMHVAVDVVEGIRFLHSQGLVHRDIKLKNVLLDSKNRGKITDLGFCKPEAMMSGSIVGTPIHMAPELFSGHYDNSVDVYALGILLWYICAGTVRLPLAFEQCASKDHLWNAVRRGVRPERLANFDEECWMLMEACWSGDPSARPLLGDIQPQLV 889          

Query: 2272 ILFIMDRMARDFYAALKQGLDWVTRLQVSLDVIEGIRFLHSQGLIHRDIKLKNVLLDYNNRGKLTDLGFCKPCAMLSGSLVGTPIHMAPELFNQEYNFSVDIYAFGILFWYVCSNKVKVPTNFDRFTNKESLFEAVKKGLRPERPPKIDQ---ECWDLISRCWHQDPNKRPLPGEIEDQL 2802
            +L + +RMA D + AL +      RL++ LDV   +++LHS  LIHRD+KL+NVL+D  ++G LTD G CK   ++  SLVGTP  MAPE+  Q YN SVD+YAFGIL W VC  +   P N     +   +   V+  L   +P ++D+    CW+L+ RCW   P++RP   EIE  L
Sbjct:   32 VLIVSERMASDLHRALPRLTSLRKRLEILLDVARALKYLHSLDLIHRDVKLQNVLVDEKSQGSLTDFGLCKAEGVMENSLVGTPTSMAPEMVKQNYNKSVDVYAFGILMWRVCEGQGNQPRNI--ALHPIPIIMLVRNALEDRKPERLDRFMGPCWNLMERCWATVPDQRPNFQEIESDL 209          

Query: 1783 RTSSDMLNSISEVKLTHEVINQITENLKQSHENF---IISIKRLENRVEVRQNKHAEMQDRIKRLYTPKLARLYLEGMSLRDNVLFGVPKLNREIGRGQYGVVYACNT--WGAYNQMAVKSVV--PPDEKHWCDLAME--FFYCKQMSEHDRIATIHGSV-VDYNYSYG-----SNPAILFIMDRMARDFYAALKQGLDWVTRLQVSLDVIEGIRFLHSQGLIHRDIKLKNVLLDYNNRGKLTDLGFCKPCAMLSGSLVGTPIHMAPELFNQ----EYNFSVDIYAFGILFWYVCSNKV-KVPTNFDRFTNKESLFEAVKKGLRPERPPKIDQECWDLISRCW 2751
            + +  +L+ +   K++   I    E L    E F   I +IKRL + +    +      D ++ ++ P +A L   G SL++ +  G  KL   + R    VVY C++  WG  ++  VK V     D+K W    ++  F Y       D ++ + G   V++   +G         +  +M+R+  D   AL++GL W  RL V+ DV  G++ +H    ++RD+K +NV++ +N   K+     CKP      + +G P H++PE++ +      + S DIYAFG L+W +C     K P  F+   + ES+ +A  +G  PERP  +    WDL+ +CW
Sbjct:    3 KVAQTLLSKLDSKKISDSAIKTCKEILNHMLEKFVGRIETIKRLNDTLASIPDDF----DNLRLVHVPHVAELVARGYSLQNIMNKGPVKLGAVLSRTANSVVYECSSPAWGGLDKSVVKVVKRDALDDKVWKQYILDAPFLY----PFRDIMSRLGGKCPVNHLRLFGWCLLPPCEEMYIVMERVRCDLLTALQEGLSWEQRLTVAKDVARGLQKIHKAEYVYRDLKPQNVMISFNGCAKIN---MCKPEKPFEITKLGLPFHISPEMYKRPSPGSSSSSFDIYAFGSLWWVICEGTGNKRPRAFEFCHDSESMEQATLEGRWPERPQGVSDASWDLMVQCW 334          

Query: 2437 LDYNNRGKLTDLGFCKPCAMLSGSLVGTPIHMAPELFNQEYNFSVDIYAFGILFWYVCSNKVKVPTNFDRFTNKESLFEAVKKGLRPERPPKIDQ---ECWDLISRCWHQDPNKRPLPGEIEDQL---LLMKT 2817
            +D  ++G LTD G CK   ++  SLVGTP  MAPE+  Q YN SVD+YAFGIL W VC  +   P N     +   +   V+  L   +P ++D+    CW+L+ RCW   P++RP   EIE  L   LL KT
Sbjct:    1 VDEKSQGSLTDFGLCKAEGVMENSLVGTPTSMAPEMVKQNYNKSVDVYAFGILMWRVCEGQGNQPRNI--ALHPIPIIMLVRNALEDRKPERLDRFMGPCWNLMERCWATVPDQRPNFQEIESDLQEILLDKT 131          

Query: 2044 LNREIGRGQYGVVYACNTWGAYNQMAVKSV----VPPDEKHWCDLAMEFFYCKQMSEHDRIATIHGSVVDYNYSYGSNPAILFIMDRMAR--DFYAALK----------QGLDWVTRLQVSLDVIEGIRFLHSQGLIHRDIKLKNVLLDYNNRGKLTDLGFCK---PCAMLSGSLVGTPIHMAPELF-NQEYNFSVDIYAFGILFWYVCSNKVKVPTNFDRFTNKE--SLFEAVKKGLRPERPPKIDQECWDLISRCWHQDPNKRP 2775
            + + IG+G YG V+         Q  +K V        E+   +L  +     Q+         H ++V Y  S+  +   L+I        D Y+ LK          Q ++W  ++ ++L      +++H + ++HRD+K +N+ L  +   K+ DLG  +     + ++ +L+GTP +M+PELF N+ YN   D++A G   + +C+ +         F  K+  SL   + KG  P  P +   +   +I     QDP+KRP
Sbjct:    8 IGKCIGKGSYGEVFLSKHKKDKKQYVLKKVDLQKASVRERKAAELEAKLL--SQLR--------HPNIVSYRESFQDDTGFLYIAMNFCEGGDLYSRLKAQKGIPLDENQIVEWFVQIAMAL------QYMHEKHILHRDLKTQNIFLTKSKIIKVGDLGIARVLESSSDMATTLIGTPYYMSPELFSNKPYNHKSDVWALGCCLYEMCTLR-------HAFNAKDMSSLVYKILKGKTPPLPKQYSTDLCSIIKSMLDQDPDKRP 250          

Query:  613 LFEGIKVVVMPSIKQKAIEEIRAIYD-SHISDLLPILIYAFEFNDLSSWDKTELEEIKLLAQDSPIFFVKVPPYEKYSRLPADYKFTKEELLAVLNPPISFAPN-GRKVSNTNANDSGDMKLFGTLCQMNLISAVNNGFFSLTRSPKLETIDLNDLKIDSDLITQFDSFFEKLTNYCHSCIQKYLVRVLTIITKFASDALKNLILQVYDLSYSSVITPKKVEFAKQQELLLYNSLISRSTEKHEEICSLIGEILNIMK-QTLPDAAAVEID--LESFQDKMVSIKMYKSATNTVREYVASKVNSAIAEKLLQSMDVLRNTYVGTLERTVNSLGK--FEEENINATE-ALKNILHFTYGLHIPIKTSSTFMSSLIEKMKQLISRLPWQPDPTLDANWVMRTSSDMLNSISEVKLTHEVINQITENLKQSHENFIISIKRLENRVEVRQNKHAEMQDRIKRLYTPKLARLYLEGMSLRDNVLFGVPKLNREIGRGQYGVVYACNTWGAYNQMAVKSVVPPDEKHWCDLAMEFFYCKQMSEHDRIATIHGSVVDYNYSYGSNPAILFIMDRMARDFYAALKQGLDWVTRLQVSLDVIEGIRFLHSQGLIHRDIKLKNVLLDYNNRGKLTDLGFCKPCAMLSGSLVGTPIHMAPELFNQEYNFSVDIYAFGILFWYVCSNKVKVPTNFDRFTNKESLFEAVKKGLRPERPPKIDQECWDLISRCWHQDPNKRPLPGEIEDQL 2802
            L +  KV+V+P    + IEE  A+ D SH   ++PI++YA   + L++   +EL +++ +    PI FV++P                       +  ++ +P  GR        +     L   L  +  +++          +P L  I     K  S L   FD     L  +    +Q   V    ++       L   I Q +D+     ITP+++E+ +++E  L++SL++ +  K EE+  +I E L  MK Q L DAA +E    + +   + V+ K  KS  + ++E +  ++N A+A KL+ S+D LR ++VGTLER ++SL K   +    N T   LK +L+  Y + +   + S+    + E++KQ+I R+ +   P +   W  + + D + S+S  KL   + +Q    L  SHE F  S+++LE     R  +  ++  R+++ + P+LARL LE  SLRD +L G P+L RE+GRGQYGVVY C +WG +   A+KSVVPPD+KHW DLA+EF Y + + +H+R+  +HGSV+D++Y  GS+ A+L IM+R+ RD Y  LK GL    RLQ++LDV+EGIRFLH QGL+HRDIKLKNVLLD  NR K+TDLGFCKP AM+SGS+VGTPIHMAPELF  +Y+ SVD+YAFGILFWY+C+  VK+P  F++ ++K+ L+  VKKG RPER P  D+ECW L+  CW+ DP+ RPL G +E  L
Sbjct:  183 LLQEAKVMVVPCPSVQPIEE--ALEDCSHC--VIPIILYAVNQDSLTADQVSELWKVREML-SFPICFVRLP-----------------------DGALNASPEPGRGADKEKEKEREKSSLHKQLLSLGFLTSPTGN--CSCGAPTL--IPAPGAKPQSMLGESFDRLHRLLVPFTRQVLQNQQVEAANVLNGLHCRCLDLFINQAFDMQRDLQITPRRLEYTREKEGELFSSLMAIANRKQEEMKEMIVETLGSMKEQLLEDAANLEFTDVIVTPNGEPVTSKEIKSCIHLIQELIVVRLNQAVANKLISSVDYLRESFVGTLERCLSSLEKSTLDSSVHNVTSNHLKQLLNAAYHVEVTFHSGSSVTRFVWEQIKQIIHRITFVNPPAITPEWKRKVAQDAIESLSAAKLARSICSQFRTRLNSSHEAFAASLRQLEEGHTGRLERTEDLWLRVRKDHAPRLARLSLESRSLRDVLLHGKPRLGRELGRGQYGVVYLCESWGGHYPCALKSVVPPDDKHWNDLALEFHYTRSLPKHERLVDLHGSVIDHSYGGGSSIAVLLIMERLHRDLYTGLKAGLSLRERLQIALDVVEGIRFLHGQGLLHRDIKLKNVLLDKQNRAKITDLGFCKPEAMMSGSIVGTPIHMAPELFTGKYDNSVDVYAFGILFWYLCTGSVKLPEAFEKCSSKDQLWNNVKKGARPERLPSFDEECWQLMEACWNGDPSLRPLLGIVEPGL 888          

Query:  613 LFEGIKVVVMPSIKQKAIEEIRAIYD-SHISDLLPILIYAFEFNDLSSWDKTELEEIKLLAQDSPIFFVKVPPYEKYSRLPADYKFTKEELLAVLNPPISFAPN-GRKVSNTNANDSGDMKLFGTLCQMNLISAVNNGFFSLTRSPKLETIDLNDLKIDSDLITQFDSFFEKLTNYCHSCIQKYLVRVLTIITKFASDALKNLILQVYDLSYSSVITPKKVEFAKQQELLLYNSLISRSTEKHEEICSLIGEILNIMK-QTLPDAAAVEID--LESFQDKMVSIKMYKSATNTVREYVASKVNSAIAEKLLQSMDVLRNTYVGTLERTVNSLGK--FEEENINATE-ALKNILHFTYGLHIPIKTSSTFMSSLIEKMKQLISRLPWQPDPTLDANWVMRTSSDMLNSISEVKLTHEVINQITENLKQSHENFIISIKRLENRVEVRQNKHAEMQDRIKRLYTPKLARLYLEGMSLRDNVLFGVPKLNREIGRGQYGVVYACNTWGAYNQMAVKSVVPPDEKHWCDLAMEFFYCKQMSEHDRIATIHGSVVDYNYSYGSNPAILFIMDRMARDFYAALKQGLDWVTRLQVSLDVIEGIRFLHSQGLIHRDIKLKNVLLDYNNRGKLTDLGFCKPCAMLSGSLVGTPIHMAPELFNQEYNFSVDIYAFGILFWYVCSNKVKVPTNFDRFTNKESLFEAVKKGLRPERPPKIDQECWDLISRCWHQDPNKRPLPGEIEDQL 2802
            L +  KV+V+P    + IEE  A+ D SH   ++PI++YA   + L++   +EL +++ +    PI FV++P                       +  ++ +P  GR        +     L   L  +  +++          +P L  I     K  S L   FD     L  +    +Q   V    ++       L   I Q +D+     ITP+++E+ +++E  L++SL++ +  K EE+  +I E L  MK Q L DAA +E    + +   + V+ K  KS  + ++E +  ++N A+A KL+ S+D LR ++VGTLER ++SL K   +    N T   LK +L+  Y + +   + S+    + E++KQ+I R+ +   P +   W  + + D + S+S  KL   + +Q    L  SHE F  S+++LE     R  +  ++  R+++ + P+LARL LE  SLRD +L G P+L RE+GRGQYGVVY C +WG +   A+KSVVPPD+KHW DLA+EF Y + + +H+R+  +HGSV+D++Y  GS+ A+L IM+R+ RD Y  LK GL    RLQ++LDV+EGIRFLH QGL+HRDIKLKNVLLD  NR K+TDLGFCKP AM+SGS+VGTPIHMAPELF                                              G RPER P  D+ECW L+  CW+ DP+ RPL G +E  L
Sbjct:  215 LLQEAKVMVVPCPSVQPIEE--ALEDCSHC--VIPIILYAVNQDSLTADQVSELWKVREML-SFPICFVRLP-----------------------DGALNASPEPGRGADKEKEKEREKSSLHKQLLSLGFLTSPTGNCS--CGAPTL--IPAPGAKPQSMLGESFDRLHRLLVPFTRQVLQNQQVEAANVLNGLHCRCLDLFINQAFDMQRDLQITPRRLEYTREKEGELFSSLMAIANRKQEEMKEMIVETLGSMKEQLLEDAANLEFTDVIVTPNGEPVTSKEIKSCIHLIQELIVVRLNQAVANKLISSVDYLRESFVGTLERCLSSLEKSTLDSSVHNVTSNHLKQLLNAAYHVEVTFHSGSSVTRFVWEQIKQIIHRITFVNPPAITPEWKRKVAQDAIESLSAAKLARSICSQFRTRLNSSHEAFAASLRQLEEGHTGRLERTEDLWLRVRKDHAPRLARLSLESRSLRDVLLHGKPRLGRELGRGQYGVVYLCESWGGHYPCALKSVVPPDDKHWNDLALEFHYTRSLPKHERLVDLHGSVIDHSYGGGSSIAVLLIMERLHRDLYTGLKAGLSLRERLQIALDVVEGIRFLHGQGLLHRDIKLKNVLLDKQNRAKITDLGFCKPEAMMSGSIVGTPIHMAPELFT---------------------------------------------GARPERLPSFDEECWQLMEACWNGDPSLRPLLGIVEPGL 875          

Query: 2359 LDVIEGIRFLHSQGLIHRDIKLKNVLLDYNNRGKLTDLGFCKPCAMLSGS------LVGTPIHMAPELFNQEYN--FSVDIYAFGILFWYVCSNKVKVPTNFDRFTNKESLFEAVKKGLRP--ERPPKIDQ----ECWDLISRCWHQDPNKRPLPGEI 2790
            L+V  G+RFLHS G++HRD+K++NV+L  +   KL D G C   A    S      + GT  +M PE ++  Y    S D+Y+F I  W + S +   PT      +   L + + KG RP  +   K D+    +  DL+ +CW+ DP +RP   EI
Sbjct:  135 LEVASGMRFLHSMGILHRDLKMQNVMLSEDLHAKLADFGLCTMSATCCPSDEEETEISGTVKYMPPEAYDINYKPVRSFDVYSFAIFLWAILSGEEPFPT-----AHPSRLRKCIAKGQRPPLDDLSKTDKAGMSDLLDLMQKCWNGDPTQRPTFEEI 287          

Query: 2056 IGRGQYGVVYACNTWGAYNQMAVKSVVPPDEKHWCDLAMEFFYCKQMSEHDRIATIHGSVVDYNYSYGSNPAILFIMDRMARDFYAALKQG----LDWVTRLQVSLDVIEGIRFLHSQGLIHRDIKLKNVLLD-YNNRGKLTDLGFCK------PCAMLSGSLVGTPIHMAPELFNQ---EYNFSVDIYAFGILFWYVCSNKVKVPTNFDRFTNKESLFEAVKKGLRPERPPKIDQECWDLISRCWHQDPNKRPLPGEI 2790
            +GRG YGVVYA        ++A+K +   D ++   L  E    K +         H ++V Y  S   N  I   M+++     +AL +     L   T +  +  ++EG+R+LH   ++HRDIK  NVL++ Y+   K++D G  K      PC   + +  GT  +MAPE+ ++    Y    DI++ G     + + K   P   +    + ++F+     + PE P  +  E    I RC+  DPNKRP+  ++
Sbjct:  624 LGRGTYGVVYAGRDLSNQVRIAIKEIPERDSRYSQPLHEEIALHKYLK--------HRNIVQYLGSISENGFIKIFMEQVPGGSLSALLRSKWGPLKEATIIFYTRQILEGLRYLHENQIVHRDIKGDNVLVNTYSGVLKISDFGTSKRLAGVNPC---TETFTGTLQYMAPEIIDKGPRGYGAPADIWSLGCTIIEMATGK---PPFHELGEPQAAMFKVGMFKIHPEIPESLSLEAKSFILRCFEPDPNKRPITTDL 868          

Query: 1897 KRLENRVEVRQNKHAEMQDRIKRL--YTPKLARLYLEGMSLR-------------DNVLFGVPKLNREIGRGQYGVVYACNTWGAYNQMAVKSVVPPDEKHWCDLAMEFFYCKQMSEHDRIATIHGSVVDYNYS-YGSNPAILFIMDRMARD---FYAALKQGLDWVTRLQVSLDVIEGIRFLHSQGLIHRDIKLKNVLLDYNNRGKLTDLGFCKPCAM---LSGSLVGTPIHMAPE-LFNQEYNFSVDIYAFGILFWYVCSNKVKVPTNFDRFTNKESLFEAVKKGLRPERPPKIDQECWDLISRCWHQDPNKR 2772
            K++ N   + Q   AE   ++ ++  Y     RL+ EG S R             DN +F     ++ +G+G +G V      G+    AVK++     K    L  +   C  + +           + + YS + +   + F+M+ +      F+   K   D       S +++ G+ FLHS+G+I+RD+KL NV+L++    K+ D G CK        + +  GTP ++APE L  Q+Y+FSVD ++FG+L + +     + P + D   +++ LFE+++    P  P  I++E  DL+ + + ++P  R
Sbjct:  263 KKVANLCGINQKLLAEALTQVSQVSSYASPYGRLW-EGCSPRPQSRITHLTRINVDNFIF-----HKVLGKGSFGKVLLAELKGSGEYFAVKAL-----KKEVVLMDDDVECTMVEKRVLALAWENPFLTHLYSTFQTKEHLFFVMEYLNGGDLMFHIQEKGRFDLNRATFYSAEIVCGLEFLHSKGIIYRDLKLDNVMLNHEGHIKIADFGMCKEDVFGDNRATTFCGTPDYIAPEILLGQKYSFSVDWWSFGVLLYEMLVG--QSPFHGD---DEDELFESIRMDT-PHYPRWINKEAKDLLEQLFDREPTHR 560          

Query:   55 MNSGQTKKKKLKNYSYTYCLAEEIKRFRVAKNQXXXXXXXXXXXXXYLSNDENIKLEAVKANIPTQIPMEIDNETRFLTDKDLSLIIMGQTHYTKSVIVNEIFKKRIMPIKYDQPNAPWKMIKFHYGIKTITSLCEFDNAFDLGDRTNLLNKQDCINEEVLIDNAAKSDDEAFENSYVDVMHSSDILFEGIKVVVMPSIKQKAIEEIRAIYDSHISDLLPILIYAFEFNDLSSWDKTELEEIKLLAQDSPIFFVKVPPYEKYSRLPADYKFTKEELLAVLNPPISFAPNGRKVSNTNANDSGDMKLFGTLCQMNLISAVNNGFFSLTRSPKLETIDLNDLKIDSDLITQFDSFFEKLTNYCHSCIQKYLVRVLTIITKFASDALKNLILQVYDLSYSSVITPKKVEFAKQQELLLYNSLISRSTEKHEEICSLIGEILNIMKQTLPDAAAVEIDLESFQDKMVSIKMYKSATNTVREYVASKVNSAIAEKLLQSMDVLRNTYVGTLERTV 1584
            MNSGQTKKKKLKNYSYTYCLAEEIKRFRVAKNQIKKIFKEFKKSFSYLSNDENIKLEAVKANIPTQIPMEIDNETRFLTDKDLSLIIMGQTHYTKSVIVNEIFKKRIMPIKYDQPNAPWKMIKFHYGIKTITSLCEFDNAFDLGDRTNLLNKQDCINEEVLIDNAAKSDDEAFENSYVDVMHSSDILFEGIKVVVMPSIKQKAIEEIRAIYDSHISDLLPILIYAFEFNDLS WDKTELEEIKLLAQDSPIFFVKVPPYEKYSRLPADYKFTKEELLAVLNPPISFAPNGRKVSNTNANDSGDMKLFGTLCQMNLISAVNNGFFSLTRSPKLETIDLNDLKIDSDLITQFDSFFEKLTNYCHSCIQKYLVRVLTIITKFASDALKNLILQVYDLSYSSVITPKKVEFAKQQELLLYNSLISRSTEKHEEICSLIGEILNIMKQTLPDAAAVEIDLE   +KMVSIKMYKSATNTVREYVASKVNSAIAEKLLQSMDVLRNTYVGTLERTV
Sbjct:    1 MNSGQTKKKKLKNYSYTYCLAEEIKRFRVAKNQIKKIFKEFKKSFSYLSNDENIKLEAVKANIPTQIPMEIDNETRFLTDKDLSLIIMGQTHYTKSVIVNEIFKKRIMPIKYDQPNAPWKMIKFHYGIKTITSLCEFDNAFDLGDRTNLLNKQDCINEEVLIDNAAKSDDEAFENSYVDVMHSSDILFEGIKVVVMPSIKQKAIEEIRAIYDSHISDLLPILIYAFEFNDLSPWDKTELEEIKLLAQDSPIFFVKVPPYEKYSRLPADYKFTKEELLAVLNPPISFAPNGRKVSNTNANDSGDMKLFGTLCQMNLISAVNNGFFSLTRSPKLETIDLNDLKIDSDLITQFDSFFEKLTNYCHSCIQKYLVRVLTIITKFASDALKNLILQVYDLSYSSVITPKKVEFAKQQELLLYNSLISRSTEKHEEICSLIGEILNIMKQTLPDAAAVEIDLE---NKMVSIKMYKSATNTVREYVASKVNSAIAEKLLQSMDVLRNTYVGTLERTV 507          

Query:   55 MNSGQTKKKKLKNYSYTYCLAEEIKRFRVAKNQXXXXXXXXXXXXXYLSNDENIKLEAVKANIPTQIPMEIDNETRFLTDKDLSLIIMGQTHYTKSVIVNEIFKKRIMPIKYDQPNAPWKMIKFHYGIKTITSLCEFDNAFDLGDRTNLLNKQDCINEEVLIDNAAKSDDEAFENSYVDVMHSSDILFEGIKVVVMPSIKQKAIEEIRAIYDSHISDLLPILIYAFEFNDLSSWDKTELEEIKLLAQDSPIFFVKVPPYEKYSRLPADYKFTKEELLAVLNPPISFAPNGRKVSNTNANDSGDMKLFGTLCQMNLISAVNNGFFSLTRSPKLETIDLNDLKIDSDLITQFDSFFEKLTNYCHSCIQKYLVRVLTIITKFASDALKNLILQVYDLSYSSVITPKKVEFAKQQELLLYNSLISRSTEKHEEICSLIGEILNIMKQTLPDAAAVEIDLESFQDKMVSI 1449
            MNSGQTKKKKLKNYSYTYCLAEEIKRFRVAKNQIKKIFKEFKKSFSYLSNDENIKLEAVKANIPTQIPMEIDNETRFLTDKDLSLIIMGQTHYTKSVIVNEIFKKRIMPIKYDQPNAPWKMIKFHYGIKTITSLCEFDNAFDLGDRTNLLNKQDCINEEVLIDNAAKSDDEAFENSYVDVMHSSDILFEGIKVVVMPSIKQKAIEEIRAIYDSHISDLLPILIYAFEFNDLS WDKTELEEIKLLAQDSPIFFVKVPPYEKYSRLPADYKFTKEELLAVLNPPISFAPNGRKVSNTNANDSGDMKLFGTLCQMNLISAVNNGFFSLTRSPKLETIDLNDLKIDSDLITQFDSFFEKLTNYCHSCIQKYLVRVLTIITKFASDALKNLILQVYDLSYSSVITPKKVEFAKQQELLLYNSLISRSTEKHEEICSLIGEILNIMKQTLPDAAAVEIDLE    K+  I
Sbjct:    1 MNSGQTKKKKLKNYSYTYCLAEEIKRFRVAKNQIKKIFKEFKKSFSYLSNDENIKLEAVKANIPTQIPMEIDNETRFLTDKDLSLIIMGQTHYTKSVIVNEIFKKRIMPIKYDQPNAPWKMIKFHYGIKTITSLCEFDNAFDLGDRTNLLNKQDCINEEVLIDNAAKSDDEAFENSYVDVMHSSDILFEGIKVVVMPSIKQKAIEEIRAIYDSHISDLLPILIYAFEFNDLSPWDKTELEEIKLLAQDSPIFFVKVPPYEKYSRLPADYKFTKEELLAVLNPPISFAPNGRKVSNTNANDSGDMKLFGTLCQMNLISAVNNGFFSLTRSPKLETIDLNDLKIDSDLITQFDSFFEKLTNYCHSCIQKYLVRVLTIITKFASDALKNLILQVYDLSYSSVITPKKVEFAKQQELLLYNSLISRSTEKHEEICSLIGEILNIMKQTLPDAAAVEIDLERMGTKLYEI 465          

Query:   55 MNSGQTKKKKLKNYSYTYCLAEEIKRFRVAKNQXXXXXXXXXXXXXYLSNDENIKLEAVKANIPTQIPMEIDNETRFLTDKDLSLIIMGQTHYTKSVIVNEIFKKRIMPIKYDQPNAPWKMIKFHYGIKTITSLCEFDNAFDLGDRTNLLNKQDCINEEVLIDNAAKSDDEAFENSYVDVMHSSDILFEGIKVVVMPSIKQKAIEEIRAIYDSHISDLLPILIYAFEFNDLSSWDKTELEEIKLLAQDSPIFFVKVPPYEKYSRLPADYKFTKEELLAVLNPPISFAPNGRKVSNTNANDSGDMKLFGTLCQMNLISAVNNGFFSLTRSPKLETIDLNDLKIDSDLITQFDSFFEKLTNYCHSCIQKYLVRVLTIITKFASDALKNLILQVYDLSYSSVITPKKVEFAKQQELLLYNSLISRSTEKHEEICSLIGEILNIMKQTLPDAAAVEIDLESFQDKMVSI 1449
            MNSGQTKKKKLKNYSYTYCLAEEIKRFRVAKNQIKKIFKEFKKSFSYLSNDENIKLEAVKANIPTQIPMEIDNETRFLTDKDLSLIIMGQTHYTKSVIVNEIFKKRIMPIKYDQPNAPWKMIKFHYGIKTITSLCEFDNAFDLGDRTNLLNKQDCINEEVLIDNAAKSDDEAFENSYVDVMHSSDILFEGIKVVVMPSIKQK                                DKTELEEIKLLAQDSPIFFVKVPPYEKYSRLPADYKFTKEELLAVLNPPISFAPNGRKVSNTNANDSGDMKLFGTLCQMNLISAVNNGFFSLTRSPKLETIDLNDLKIDSDLITQFDSFFEKLTNYCHSCIQKYLVRVLTIITKFASDALKNLILQVYDLSYSSVITPKKVEFAKQQELLLYNSLISRSTEKHEEICSLIGEILNIMKQTLPDAAAVEIDLE    K+  I
Sbjct:    1 MNSGQTKKKKLKNYSYTYCLAEEIKRFRVAKNQIKKIFKEFKKSFSYLSNDENIKLEAVKANIPTQIPMEIDNETRFLTDKDLSLIIMGQTHYTKSVIVNEIFKKRIMPIKYDQPNAPWKMIKFHYGIKTITSLCEFDNAFDLGDRTNLLNKQDCINEEVLIDNAAKSDDEAFENSYVDVMHSSDILFEGIKVVVMPSIKQK--------------------------------DKTELEEIKLLAQDSPIFFVKVPPYEKYSRLPADYKFTKEELLAVLNPPISFAPNGRKVSNTNANDSGDMKLFGTLCQMNLISAVNNGFFSLTRSPKLETIDLNDLKIDSDLITQFDSFFEKLTNYCHSCIQKYLVRVLTIITKFASDALKNLILQVYDLSYSSVITPKKVEFAKQQELLLYNSLISRSTEKHEEICSLIGEILNIMKQTLPDAAAVEIDLERMGTKLYEI 433          

Query: 1780 MRTSSDMLNSISEVKLTHEVINQITENLKQSHENFIISIKRLENRVEVRQNKHAEMQDRIKRLYTPKLARLYLEGMSLRDNVLFGVPKLNREIGRGQYGVVYACNTWGAYNQMAVKSVVPPDEKHWCDLAMEFFYCKQMSEHDRIATIHGSVVDYNYSYGSNPAILFIMDRMARDFYAALKQGLDWVTRLQVSLDVIEGIRFLHSQGLIHRDIKLKNVLLDYNNRGKLTDLGFCKPCAMLSGSLVGTPIHMAPELFNQEYNFSVDIYAFGILFWYVCSNKVKVPTNFDRFTNKESLFEAVKKGLRPERPPKIDQECWDLISRCWHQDPNKRPLPGEIEDQLLLMKTKAQNLNIFNQSIISRDNSNCLGR 2886
            MRTSSDMLNSISEVKLTHEVINQITENLKQSHENFIISIKRLENRVEVRQNKHAEMQDRIKRLYTPKLARLYLEGMSLRDNVLFGVPKLNREIGRGQYGVVYACNTWGAYNQMAVKSVVPPDEKHWCDLAMEFFYCKQMSEHDRIATIHGSVVDYNYSYGSNPAILFIMDRMARDFYAALKQGLDWVTRLQVSLDVIEGIRFLHSQGLIHRDIKLKNVLLDYNNRGKLTDLGFCKPCAMLSGSLVGTPIHMAPELFNQEYNFSVDIYAFGILFWYVCSNKVKVPTNFDRFTNKESLFEAVKKGLRPERPPKIDQECWDLISRCWHQDPNKRPLPGEIEDQLLLMKTKAQNLNIFNQSIISRDNSNCLGR
Sbjct:    1 MRTSSDMLNSISEVKLTHEVINQITENLKQSHENFIISIKRLENRVEVRQNKHAEMQDRIKRLYTPKLARLYLEGMSLRDNVLFGVPKLNREIGRGQYGVVYACNTWGAYNQMAVKSVVPPDEKHWCDLAMEFFYCKQMSEHDRIATIHGSVVDYNYSYGSNPAILFIMDRMARDFYAALKQGLDWVTRLQVSLDVIEGIRFLHSQGLIHRDIKLKNVLLDYNNRGKLTDLGFCKPCAMLSGSLVGTPIHMAPELFNQEYNFSVDIYAFGILFWYVCSNKVKVPTNFDRFTNKESLFEAVKKGLRPERPPKIDQECWDLISRCWHQDPNKRPLPGEIEDQLLLMKTKAQNLNIFNQSIISRDNSNCLGR 369          

Query: 1798 MLNSISEVKLTHEVINQITENLKQSHENFIISIKRLENRVEVRQNKHAEMQDRIKRLYTPKLARLYLEGMSLRDNVLFGVPKLNREIGRGQYGVVYACNTWGAYNQMAVKSVVPPDEKHWCDLAMEFFYCKQMSEHDRIATIHGSVVDYNYSYGSNPAILFIMDRMARDFYAALKQGLDWVTRLQVSLDVIEGIRFLHSQGLIHRDIKLKNVLLDYNNRGKLTDLGFCKPCAMLSGSLVGTPIHMAPELFNQEYNFSVDIYAFGILFWYVCSNKVKVPTNFDRFTNKESLFEAVKKGLRPERPPKIDQECWDLISRCWHQDPNKRPLPGEIEDQLLLMKTKAQNLNIFNQSIISRDNSNCLGR 2886
            MLNSISEVKLTHEVINQITENLKQSHENFIISIKRLENRVEVRQNKHAEMQDRIKRLYTPKLARLYLEGMSLRDNVLFGVPKLNREIGRGQYGVVYACNTWGAYNQMAVKSVVPPDEKHWCDLAMEFFYCKQMSEHDRIATIHGSVVDYNYSYGSNPAILFIMDRMARDFYAALKQGLDWVTRLQVSLDVIEGIRFLHSQGLIHRDIKLKNVLLDYNNRGKLTDLGFCKPCAMLSGSLVGTPIHMAPELFNQEYNFSVDIYAFGILFWYVCSNKVKVPTNFDRFTNKESLFEAVKKGLRPERPPKIDQECWDLISRCWHQDPNKRPLPGEIEDQLLLMKTKAQNLNIFNQSIISRDNSNCLGR
Sbjct:    1 MLNSISEVKLTHEVINQITENLKQSHENFIISIKRLENRVEVRQNKHAEMQDRIKRLYTPKLARLYLEGMSLRDNVLFGVPKLNREIGRGQYGVVYACNTWGAYNQMAVKSVVPPDEKHWCDLAMEFFYCKQMSEHDRIATIHGSVVDYNYSYGSNPAILFIMDRMARDFYAALKQGLDWVTRLQVSLDVIEGIRFLHSQGLIHRDIKLKNVLLDYNNRGKLTDLGFCKPCAMLSGSLVGTPIHMAPELFNQEYNFSVDIYAFGILFWYVCSNKVKVPTNFDRFTNKESLFEAVKKGLRPERPPKIDQECWDLISRCWHQDPNKRPLPGEIEDQLLLMKTKAQNLNIFNQSIISRDNSNCLGR 363