Rho guanine nucleotide exchange factor
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Overview
Neoblast Clusters
Zeng et. al., 2018▻ Overview▻ Neoblast Population▻ Sub-lethal Irradiated Surviving X1 and X2 Cell Population
Overview
Single cell RNA-seq of pluripotent neoblasts and its early progeniesWe isolated X1 neoblasts cells enriched in high piwi-1 expression (Neoblast Population), and profiled ∼7,614 individual cells via scRNA-seq. Unsupervised analyses uncovered 12 distinct classes from 7,088 high-quality cells. We designated these classes Nb1 to Nb12 and ordered them based on high (Nb1) to low (Nb12) piwi-1 expression levels. We further defined groups of genes that best classified the cells parsed into 12 distinct cell clusters to generate a scaled expression heat map of discriminative gene sets for each cluster. Expression of each cluster’s gene signatures was validated using multiplex fluorescence in situ hybridization (FISH) co-stained with piwi-1 and largely confirmed the cell clusters revealed by scRNA-seq.We also tested sub-lethal irradiation exposure. To profile rare pluripotent stem cells (PSCs) and avoid interference from immediate progenitor cells, we determined a time point after sub-lethal irradiation (7 DPI) with minimal piwi-1+ cells, followed by isolation and single-cell RNA-seq of 1,200 individual cells derived from X1 (Piwi-1 high) and X2 (Piwi-1 low) cell populations (Sub-lethal Irradiated Surviving X1 and X2 Cell Population)Explore this single cell expression dataset with our NB Cluster Shiny App
Neoblast Population
Sub-lethal Irradiated Surviving X1 and X2 Cell Population
Embryonic Expression
Davies et. al., 2017
Hover the mouse over a column in the graph to view average RPKM values per sample. Embryonic Stages: Y: yolk. S2-S8: Stages 2-8. C4: asexual adult. SX: virgin, sexually mature adult. back to top Anatomical Expression
PAGE et. al., 2020SMED30011603 has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGEPAGE Curations: 8
Homology
BLAST of Rho guanine nucleotide exchange factor vs. Ensembl Human
Match: ARHGEF26 (Rho guanine nucleotide exchange factor 26 [Source:HGNC Symbol;Acc:HGNC:24490]) HSP 1 Score: 151.369 bits (381), Expect = 1.075e-36 Identity = 133/473 (28.12%), Postives = 216/473 (45.67%), Query Frame = 1
Query: 1009 RLRWAETEEGKKLINMQKLSEDIIKWQEAQFEVITSEASYYRSLEVLVNKIYKSSWMDCAKEKKNMQDNLSPELDDPPNPFTKPIITATQKHHLFSNILEIHIVSGELLKALESRWRENPLIKDLSDILVDFCSEKLKPYVTYLRNQRFQTDTYNKLL-NYPEFLNIIKKFENDPDCSMMNLCSFLMLPMQRVLRLKLLMTVVKHHIPKGYPT-DGCDEAIEALEKLIKECSDEKMVMEQKEEILLICNRLIIKDK-MNVSIGSKPLLKNGALKVISNNKHASKLLGSSLLNRNNKRAQLY--LFEDQLIIAKQR------------KLPLCVSSDDNREVVVDTCQRFNVKFVEISPQKPLSRFNFKLVLSNGMKGSAEYICSVDNPDDLNEWKNAF--SVNKSRHEEFDFGEAFVICDYTPTSKKEIGLKKGQILNIIKRI-----DNERAIASFSGKQGEILLSCVQYVS 2355
R W++ K+ Q +S++ K QEA FEVI+SE SY SLE+L+ +++K+S K + D + T T++HHLFSNI ++ S + LE+R + N I D+SDI+ + PYV Y N+ +Q T KLL P F ++ + E+ DC + + SFL+LPMQRV RL LLM + PK P + C A++ + KL++ C++ ME+ E + I ++L K K + S+ L+K G L + + L +R + Q+Y LF D LII K++ + L V S DN E +++ N + S Q S VLSN E + + + W A S K + + ++ +T E+ L+ ++ I +R+ + ER G++G + C + ++
Sbjct: 415 RSTWSQLSAVKRKGLSQTVSQEERKRQEAIFEVISSEHSYLLSLEILI-RMFKNS--------KELSDTM----------------TKTERHHLFSNITDVCEASKKFFIELEARHQNNIFIDDISDIVEKHTASTFDPYVKYCTNEVYQQRTLQKLLATNPSFKEVLSRIESHEDCRNLPMISFLILPMQRVTRLPLLMDTICQKTPKDSPKYEVCKRALKEVSKLVRLCNEGARKMERTEMMYTINSQLEFKIKPFPLVSSSRWLVKRGELTAYVED--------TVLFSRRTSKQQVYFFLFNDVLIITKKKSEESYNVNDYSLRDQLLVESCDNEE--LNSSPGKNSSTMLYSRQSSASHLFTLTVLSNHANEKVEMLLGAETQSERARWITALGHSSGKPPADRTSLTQVEIVRSFTAKQPDELSLQVADVVLIYQRVSDGWYEGERL---RDGERGWFPMECAKEIT 849
BLAST of Rho guanine nucleotide exchange factor vs. Ensembl Human
Match: ARHGEF26 (Rho guanine nucleotide exchange factor 26 [Source:HGNC Symbol;Acc:HGNC:24490]) HSP 1 Score: 151.369 bits (381), Expect = 1.075e-36 Identity = 133/473 (28.12%), Postives = 216/473 (45.67%), Query Frame = 1
Query: 1009 RLRWAETEEGKKLINMQKLSEDIIKWQEAQFEVITSEASYYRSLEVLVNKIYKSSWMDCAKEKKNMQDNLSPELDDPPNPFTKPIITATQKHHLFSNILEIHIVSGELLKALESRWRENPLIKDLSDILVDFCSEKLKPYVTYLRNQRFQTDTYNKLL-NYPEFLNIIKKFENDPDCSMMNLCSFLMLPMQRVLRLKLLMTVVKHHIPKGYPT-DGCDEAIEALEKLIKECSDEKMVMEQKEEILLICNRLIIKDK-MNVSIGSKPLLKNGALKVISNNKHASKLLGSSLLNRNNKRAQLY--LFEDQLIIAKQR------------KLPLCVSSDDNREVVVDTCQRFNVKFVEISPQKPLSRFNFKLVLSNGMKGSAEYICSVDNPDDLNEWKNAF--SVNKSRHEEFDFGEAFVICDYTPTSKKEIGLKKGQILNIIKRI-----DNERAIASFSGKQGEILLSCVQYVS 2355
R W++ K+ Q +S++ K QEA FEVI+SE SY SLE+L+ +++K+S K + D + T T++HHLFSNI ++ S + LE+R + N I D+SDI+ + PYV Y N+ +Q T KLL P F ++ + E+ DC + + SFL+LPMQRV RL LLM + PK P + C A++ + KL++ C++ ME+ E + I ++L K K + S+ L+K G L + + L +R + Q+Y LF D LII K++ + L V S DN E +++ N + S Q S VLSN E + + + W A S K + + ++ +T E+ L+ ++ I +R+ + ER G++G + C + ++
Sbjct: 415 RSTWSQLSAVKRKGLSQTVSQEERKRQEAIFEVISSEHSYLLSLEILI-RMFKNS--------KELSDTM----------------TKTERHHLFSNITDVCEASKKFFIELEARHQNNIFIDDISDIVEKHTASTFDPYVKYCTNEVYQQRTLQKLLATNPSFKEVLSRIESHEDCRNLPMISFLILPMQRVTRLPLLMDTICQKTPKDSPKYEVCKRALKEVSKLVRLCNEGARKMERTEMMYTINSQLEFKIKPFPLVSSSRWLVKRGELTAYVED--------TVLFSRRTSKQQVYFFLFNDVLIITKKKSEESYNVNDYSLRDQLLVESCDNEE--LNSSPGKNSSTMLYSRQSSASHLFTLTVLSNHANEKVEMLLGAETQSERARWITALGHSSGKPPADRTSLTQVEIVRSFTAKQPDELSLQVADVVLIYQRVSDGWYEGERL---RDGERGWFPMECAKEIT 849
BLAST of Rho guanine nucleotide exchange factor vs. Ensembl Human
Match: ARHGEF26 (Rho guanine nucleotide exchange factor 26 [Source:HGNC Symbol;Acc:HGNC:24490]) HSP 1 Score: 151.369 bits (381), Expect = 1.075e-36 Identity = 133/473 (28.12%), Postives = 216/473 (45.67%), Query Frame = 1
Query: 1009 RLRWAETEEGKKLINMQKLSEDIIKWQEAQFEVITSEASYYRSLEVLVNKIYKSSWMDCAKEKKNMQDNLSPELDDPPNPFTKPIITATQKHHLFSNILEIHIVSGELLKALESRWRENPLIKDLSDILVDFCSEKLKPYVTYLRNQRFQTDTYNKLL-NYPEFLNIIKKFENDPDCSMMNLCSFLMLPMQRVLRLKLLMTVVKHHIPKGYPT-DGCDEAIEALEKLIKECSDEKMVMEQKEEILLICNRLIIKDK-MNVSIGSKPLLKNGALKVISNNKHASKLLGSSLLNRNNKRAQLY--LFEDQLIIAKQR------------KLPLCVSSDDNREVVVDTCQRFNVKFVEISPQKPLSRFNFKLVLSNGMKGSAEYICSVDNPDDLNEWKNAF--SVNKSRHEEFDFGEAFVICDYTPTSKKEIGLKKGQILNIIKRI-----DNERAIASFSGKQGEILLSCVQYVS 2355
R W++ K+ Q +S++ K QEA FEVI+SE SY SLE+L+ +++K+S K + D + T T++HHLFSNI ++ S + LE+R + N I D+SDI+ + PYV Y N+ +Q T KLL P F ++ + E+ DC + + SFL+LPMQRV RL LLM + PK P + C A++ + KL++ C++ ME+ E + I ++L K K + S+ L+K G L + + L +R + Q+Y LF D LII K++ + L V S DN E +++ N + S Q S VLSN E + + + W A S K + + ++ +T E+ L+ ++ I +R+ + ER G++G + C + ++
Sbjct: 415 RSTWSQLSAVKRKGLSQTVSQEERKRQEAIFEVISSEHSYLLSLEILI-RMFKNS--------KELSDTM----------------TKTERHHLFSNITDVCEASKKFFIELEARHQNNIFIDDISDIVEKHTASTFDPYVKYCTNEVYQQRTLQKLLATNPSFKEVLSRIESHEDCRNLPMISFLILPMQRVTRLPLLMDTICQKTPKDSPKYEVCKRALKEVSKLVRLCNEGARKMERTEMMYTINSQLEFKIKPFPLVSSSRWLVKRGELTAYVED--------TVLFSRRTSKQQVYFFLFNDVLIITKKKSEESYNVNDYSLRDQLLVESCDNEE--LNSSPGKNSSTMLYSRQSSASHLFTLTVLSNHANEKVEMLLGAETQSERARWITALGHSSGKPPADRTSLTQVEIVRSFTAKQPDELSLQVADVVLIYQRVSDGWYEGERL---RDGERGWFPMECAKEIT 849
BLAST of Rho guanine nucleotide exchange factor vs. Ensembl Human
Match: ARHGEF26 (Rho guanine nucleotide exchange factor 26 [Source:HGNC Symbol;Acc:HGNC:24490]) HSP 1 Score: 151.369 bits (381), Expect = 1.075e-36 Identity = 133/473 (28.12%), Postives = 216/473 (45.67%), Query Frame = 1
Query: 1009 RLRWAETEEGKKLINMQKLSEDIIKWQEAQFEVITSEASYYRSLEVLVNKIYKSSWMDCAKEKKNMQDNLSPELDDPPNPFTKPIITATQKHHLFSNILEIHIVSGELLKALESRWRENPLIKDLSDILVDFCSEKLKPYVTYLRNQRFQTDTYNKLL-NYPEFLNIIKKFENDPDCSMMNLCSFLMLPMQRVLRLKLLMTVVKHHIPKGYPT-DGCDEAIEALEKLIKECSDEKMVMEQKEEILLICNRLIIKDK-MNVSIGSKPLLKNGALKVISNNKHASKLLGSSLLNRNNKRAQLY--LFEDQLIIAKQR------------KLPLCVSSDDNREVVVDTCQRFNVKFVEISPQKPLSRFNFKLVLSNGMKGSAEYICSVDNPDDLNEWKNAF--SVNKSRHEEFDFGEAFVICDYTPTSKKEIGLKKGQILNIIKRI-----DNERAIASFSGKQGEILLSCVQYVS 2355
R W++ K+ Q +S++ K QEA FEVI+SE SY SLE+L+ +++K+S K + D + T T++HHLFSNI ++ S + LE+R + N I D+SDI+ + PYV Y N+ +Q T KLL P F ++ + E+ DC + + SFL+LPMQRV RL LLM + PK P + C A++ + KL++ C++ ME+ E + I ++L K K + S+ L+K G L + + L +R + Q+Y LF D LII K++ + L V S DN E +++ N + S Q S VLSN E + + + W A S K + + ++ +T E+ L+ ++ I +R+ + ER G++G + C + ++
Sbjct: 415 RSTWSQLSAVKRKGLSQTVSQEERKRQEAIFEVISSEHSYLLSLEILI-RMFKNS--------KELSDTM----------------TKTERHHLFSNITDVCEASKKFFIELEARHQNNIFIDDISDIVEKHTASTFDPYVKYCTNEVYQQRTLQKLLATNPSFKEVLSRIESHEDCRNLPMISFLILPMQRVTRLPLLMDTICQKTPKDSPKYEVCKRALKEVSKLVRLCNEGARKMERTEMMYTINSQLEFKIKPFPLVSSSRWLVKRGELTAYVED--------TVLFSRRTSKQQVYFFLFNDVLIITKKKSEESYNVNDYSLRDQLLVESCDNEE--LNSSPGKNSSTMLYSRQSSASHLFTLTVLSNHANEKVEMLLGAETQSERARWITALGHSSGKPPADRTSLTQVEIVRSFTAKQPDELSLQVADVVLIYQRVSDGWYEGERL---RDGERGWFPMECAKEIT 849
BLAST of Rho guanine nucleotide exchange factor vs. Ensembl Human
Match: NGEF (neuronal guanine nucleotide exchange factor [Source:HGNC Symbol;Acc:HGNC:7807]) HSP 1 Score: 147.517 bits (371), Expect = 3.687e-36 Identity = 123/434 (28.34%), Postives = 207/434 (47.70%), Query Frame = 1
Query: 1018 WAETEEGKKLINMQKLSEDIIKWQEAQFEVITSEASYYRSLEVLVNKIYKSSWMDCAKEKKNMQDNLSPELDDPPNPFTKPIITATQKHHLFSNILEIHIVSGELLKALESRWRENPLIKDLSDILVDFCSEKLKPYVTYLRNQRFQTDTYNKLLN-YPEFLNIIKKFENDPDCSMMNLCSFLMLPMQRVLRLKLLM-TVVKHHIPKGYPTDGCDEAIEALEKLIKECSDEKMVMEQKEEILLICNRLIIKDK-MNVSIGSKPLLKNGALKVISNNKHASKLLGSSLLNRNNKRAQLYLFEDQLIIAKQRKLPLCVSSDDNREVVVDTCQRFNVKFVEISPQ-KPLSRFNFKLVLSNGMKGSAEYICSVDNPDDLNEWKNAFSVNKSRHEEFDFGEAFVIC-------DYTPTSKKEIGLKKGQILNIIKRIDN 2286
W + E + ++ L + IK QEA FE++TSEASYY+SL +LV S +M+ + +K I+ ++ H LFSN+L++ VS L LE R EN +I D+ DI+ + ++ Y+TY+ NQ +Q TY +LL F +I + E DP C + SFL+LP QR+ RLKLL+ ++K + +A + LE ++K C++ M + E+++ I ++ K K + + S+ LLK G L+ +S K + L L + L+LF D L+I +Q +P ++ V D+ R ++ E+ Q + L+ +L N A Y+ + ++ W + + N+ R + F + C Y E+ L+ ILNI+ + D+
Sbjct: 160 WQDLPEIRSSGVLEILQPEEIKLQEAMFELVTSEASYYKSLNLLV-----SHFMENERIRK--------------------ILHPSEAHILFSNVLDVLAVSERFLLELEHRMEENIVISDVCDIVYRYAADHFSVYITYVSNQTYQERTYKQLLQEKAAFRELIAQLELDPKCRGLPFSSFLILPFQRITRLKLLVQNILKRVEERSERECTALDAHKELEMVVKACNEGVRKMSRTEQMISIQKKMEFKIKSVPIISHSRWLLKQGELQQMSGPKTSRTLRTKKLFH----EIYLFLFNDLLVICRQ--IP------GDKYQVFDSAPRGLLRVEELEDQGQTLANVFILRLLENADDREATYMLKASSQSEMKRWMTSLAPNR-RTKFVSFTSRLLDCPQVQCVHPYVAQQPDELTLELADILNILDKTDD 555
BLAST of Rho guanine nucleotide exchange factor vs. Ensembl Celegans
Match: ephx-1 (EPHeXin (Eph-interacting GEF) homolog [Source:UniProtKB/TrEMBL;Acc:A0A1D3PD25]) HSP 1 Score: 161.77 bits (408), Expect = 3.676e-41 Identity = 139/501 (27.74%), Postives = 226/501 (45.11%), Query Frame = 1
Query: 904 TTRDEDNDSIELEPNIDNDSFADNRVFQLFSATSQRLRWAETEEGKKLINMQKLSEDIIKWQEAQFEVITSEASYYRSLEVLVNKIYKSSWMDCAKEKKNMQDNLSPELDDPPNPFTKPIITATQKHHLFSNILEIHIVSGELLKALESRWRENPLIKDLSDILVDFCSEKLKPYVTYLRNQRFQTDTYNKL-LNYPEFLNIIKKFENDPDCSMMNLCSFLMLPMQRVLRLKLLMTVVKHHIPKG---YPTDGCDEAIEALEKLIKECSDEKMVMEQKEEILLICNRLIIKD----KMNVSIGSKPLLKNGALKVISNNKHASKLLGSSLLNRNNKRAQLYLFEDQLIIAKQRKLPLCVSSDDNREVVVDTCQRFNVKFVEISPQKP----------LSRFNFKL--VLSNGMKGSAEYICSVDNPDDLNEWKNAFSVNKSR------HEEFDFGEAFVICDYTPTSKKEIGLKKGQILNIIKRIDN-----ERAIASFSG 2313
+ R D + N S +R+ + SQR W E E + ++KL ++ QEA FEVITSEASY RSL VL+ S M +K + +++ + + HLFSNI + S LL LE+R EN ++ D+ DIL D + + Y+ Y NQ +Q T +L P FL+ +++ E + C +++ SFLMLPMQRV R LL+ + I Y T +A+ + +++++C++ ME+ E++L I RLI KD ++ + S+ L+K G L + + +S +L S + + ++LF D ++I K++ + V D R V I P P + R + L ++ N E + S D+ D W +A S + E+D +A V+ Y P+ E+ L G LNI++++ + ERA G
Sbjct: 111 SGRGADCSTTSASALTSNTSMRRDRLVGTSNFGSQRSLWCELPEVRAAGLLEKLDDECKLRQEAYFEVITSEASYLRSLNVLITHFMASPQMLGSKSALS-------------------VLSDSDRKHLFSNIFAVRDCSERLLCDLETRLEENLILDDICDILSDHFDKHFEVYIKYCSNQVYQDRTLRRLKTENPGFLSAVQRLEENKQCQGLDMRSFLMLPMQRVTRYPLLLYAILDRITTTDDRYKT--ATDALTSSNRVVRDCNEGARRMERTEQLLDIDRRLIYKDADLKRIPLVSNSRYLVKKGVLTQLV-ERRSSNILQS---RQKARTLHVFLFSDMIMITKKKL--------NGTFVCKDYAARRFVDMQPIEPDNPKIPLGATSNLVGRPHLFLCTLMRNARDKQTELLLSADSETDRERWLSAVRPPTSTNPEEKIYAEWDCPQALVVHAYQPSQADELQLNIGDSLNILRKMPDGWLYGERAGDGLGG 578
BLAST of Rho guanine nucleotide exchange factor vs. Ensembl Celegans
Match: ephx-1 (EPHeXin (Eph-interacting GEF) homolog [Source:UniProtKB/TrEMBL;Acc:A0A1D3PD25]) HSP 1 Score: 162.155 bits (409), Expect = 5.172e-41 Identity = 139/501 (27.74%), Postives = 226/501 (45.11%), Query Frame = 1
Query: 904 TTRDEDNDSIELEPNIDNDSFADNRVFQLFSATSQRLRWAETEEGKKLINMQKLSEDIIKWQEAQFEVITSEASYYRSLEVLVNKIYKSSWMDCAKEKKNMQDNLSPELDDPPNPFTKPIITATQKHHLFSNILEIHIVSGELLKALESRWRENPLIKDLSDILVDFCSEKLKPYVTYLRNQRFQTDTYNKL-LNYPEFLNIIKKFENDPDCSMMNLCSFLMLPMQRVLRLKLLMTVVKHHIPKG---YPTDGCDEAIEALEKLIKECSDEKMVMEQKEEILLICNRLIIKD----KMNVSIGSKPLLKNGALKVISNNKHASKLLGSSLLNRNNKRAQLYLFEDQLIIAKQRKLPLCVSSDDNREVVVDTCQRFNVKFVEISPQKP----------LSRFNFKL--VLSNGMKGSAEYICSVDNPDDLNEWKNAFSVNKSR------HEEFDFGEAFVICDYTPTSKKEIGLKKGQILNIIKRIDN-----ERAIASFSG 2313
+ R D + N S +R+ + SQR W E E + ++KL ++ QEA FEVITSEASY RSL VL+ S M +K + +++ + + HLFSNI + S LL LE+R EN ++ D+ DIL D + + Y+ Y NQ +Q T +L P FL+ +++ E + C +++ SFLMLPMQRV R LL+ + I Y T +A+ + +++++C++ ME+ E++L I RLI KD ++ + S+ L+K G L + + +S +L S + + ++LF D ++I K++ + V D R V I P P + R + L ++ N E + S D+ D W +A S + E+D +A V+ Y P+ E+ L G LNI++++ + ERA G
Sbjct: 155 SGRGADCSTTSASALTSNTSMRRDRLVGTSNFGSQRSLWCELPEVRAAGLLEKLDDECKLRQEAYFEVITSEASYLRSLNVLITHFMASPQMLGSKSALS-------------------VLSDSDRKHLFSNIFAVRDCSERLLCDLETRLEENLILDDICDILSDHFDKHFEVYIKYCSNQVYQDRTLRRLKTENPGFLSAVQRLEENKQCQGLDMRSFLMLPMQRVTRYPLLLYAILDRITTTDDRYKT--ATDALTSSNRVVRDCNEGARRMERTEQLLDIDRRLIYKDADLKRIPLVSNSRYLVKKGVLTQLV-ERRSSNILQS---RQKARTLHVFLFSDMIMITKKKL--------NGTFVCKDYAARRFVDMQPIEPDNPKIPLGATSNLVGRPHLFLCTLMRNARDKQTELLLSADSETDRERWLSAVRPPTSTNPEEKIYAEWDCPQALVVHAYQPSQADELQLNIGDSLNILRKMPDGWLYGERAGDGLGG 622
BLAST of Rho guanine nucleotide exchange factor vs. Ensembl Celegans
Match: ephx-1 (EPHeXin (Eph-interacting GEF) homolog [Source:UniProtKB/TrEMBL;Acc:A0A1D3PD25]) HSP 1 Score: 163.696 bits (413), Expect = 8.393e-41 Identity = 139/501 (27.74%), Postives = 226/501 (45.11%), Query Frame = 1
Query: 904 TTRDEDNDSIELEPNIDNDSFADNRVFQLFSATSQRLRWAETEEGKKLINMQKLSEDIIKWQEAQFEVITSEASYYRSLEVLVNKIYKSSWMDCAKEKKNMQDNLSPELDDPPNPFTKPIITATQKHHLFSNILEIHIVSGELLKALESRWRENPLIKDLSDILVDFCSEKLKPYVTYLRNQRFQTDTYNKL-LNYPEFLNIIKKFENDPDCSMMNLCSFLMLPMQRVLRLKLLMTVVKHHIPKG---YPTDGCDEAIEALEKLIKECSDEKMVMEQKEEILLICNRLIIKD----KMNVSIGSKPLLKNGALKVISNNKHASKLLGSSLLNRNNKRAQLYLFEDQLIIAKQRKLPLCVSSDDNREVVVDTCQRFNVKFVEISPQKP----------LSRFNFKL--VLSNGMKGSAEYICSVDNPDDLNEWKNAFSVNKSR------HEEFDFGEAFVICDYTPTSKKEIGLKKGQILNIIKRIDN-----ERAIASFSG 2313
+ R D + N S +R+ + SQR W E E + ++KL ++ QEA FEVITSEASY RSL VL+ S M +K + +++ + + HLFSNI + S LL LE+R EN ++ D+ DIL D + + Y+ Y NQ +Q T +L P FL+ +++ E + C +++ SFLMLPMQRV R LL+ + I Y T +A+ + +++++C++ ME+ E++L I RLI KD ++ + S+ L+K G L + + +S +L S + + ++LF D ++I K++ + V D R V I P P + R + L ++ N E + S D+ D W +A S + E+D +A V+ Y P+ E+ L G LNI++++ + ERA G
Sbjct: 482 SGRGADCSTTSASALTSNTSMRRDRLVGTSNFGSQRSLWCELPEVRAAGLLEKLDDECKLRQEAYFEVITSEASYLRSLNVLITHFMASPQMLGSKSALS-------------------VLSDSDRKHLFSNIFAVRDCSERLLCDLETRLEENLILDDICDILSDHFDKHFEVYIKYCSNQVYQDRTLRRLKTENPGFLSAVQRLEENKQCQGLDMRSFLMLPMQRVTRYPLLLYAILDRITTTDDRYKT--ATDALTSSNRVVRDCNEGARRMERTEQLLDIDRRLIYKDADLKRIPLVSNSRYLVKKGVLTQLV-ERRSSNILQS---RQKARTLHVFLFSDMIMITKKKL--------NGTFVCKDYAARRFVDMQPIEPDNPKIPLGATSNLVGRPHLFLCTLMRNARDKQTELLLSADSETDRERWLSAVRPPTSTNPEEKIYAEWDCPQALVVHAYQPSQADELQLNIGDSLNILRKMPDGWLYGERAGDGLGG 949
BLAST of Rho guanine nucleotide exchange factor vs. Ensembl Celegans
Match: ephx-1 (EPHeXin (Eph-interacting GEF) homolog [Source:UniProtKB/TrEMBL;Acc:A0A1D3PD25]) HSP 1 Score: 162.925 bits (411), Expect = 1.501e-40 Identity = 139/501 (27.74%), Postives = 226/501 (45.11%), Query Frame = 1
Query: 904 TTRDEDNDSIELEPNIDNDSFADNRVFQLFSATSQRLRWAETEEGKKLINMQKLSEDIIKWQEAQFEVITSEASYYRSLEVLVNKIYKSSWMDCAKEKKNMQDNLSPELDDPPNPFTKPIITATQKHHLFSNILEIHIVSGELLKALESRWRENPLIKDLSDILVDFCSEKLKPYVTYLRNQRFQTDTYNKL-LNYPEFLNIIKKFENDPDCSMMNLCSFLMLPMQRVLRLKLLMTVVKHHIPKG---YPTDGCDEAIEALEKLIKECSDEKMVMEQKEEILLICNRLIIKD----KMNVSIGSKPLLKNGALKVISNNKHASKLLGSSLLNRNNKRAQLYLFEDQLIIAKQRKLPLCVSSDDNREVVVDTCQRFNVKFVEISPQKP----------LSRFNFKL--VLSNGMKGSAEYICSVDNPDDLNEWKNAFSVNKSR------HEEFDFGEAFVICDYTPTSKKEIGLKKGQILNIIKRIDN-----ERAIASFSG 2313
+ R D + N S +R+ + SQR W E E + ++KL ++ QEA FEVITSEASY RSL VL+ S M +K + +++ + + HLFSNI + S LL LE+R EN ++ D+ DIL D + + Y+ Y NQ +Q T +L P FL+ +++ E + C +++ SFLMLPMQRV R LL+ + I Y T +A+ + +++++C++ ME+ E++L I RLI KD ++ + S+ L+K G L + + +S +L S + + ++LF D ++I K++ + V D R V I P P + R + L ++ N E + S D+ D W +A S + E+D +A V+ Y P+ E+ L G LNI++++ + ERA G
Sbjct: 622 SGRGADCSTTSASALTSNTSMRRDRLVGTSNFGSQRSLWCELPEVRAAGLLEKLDDECKLRQEAYFEVITSEASYLRSLNVLITHFMASPQMLGSKSALS-------------------VLSDSDRKHLFSNIFAVRDCSERLLCDLETRLEENLILDDICDILSDHFDKHFEVYIKYCSNQVYQDRTLRRLKTENPGFLSAVQRLEENKQCQGLDMRSFLMLPMQRVTRYPLLLYAILDRITTTDDRYKT--ATDALTSSNRVVRDCNEGARRMERTEQLLDIDRRLIYKDADLKRIPLVSNSRYLVKKGVLTQLV-ERRSSNILQS---RQKARTLHVFLFSDMIMITKKKL--------NGTFVCKDYAARRFVDMQPIEPDNPKIPLGATSNLVGRPHLFLCTLMRNARDKQTELLLSADSETDRERWLSAVRPPTSTNPEEKIYAEWDCPQALVVHAYQPSQADELQLNIGDSLNILRKMPDGWLYGERAGDGLGG 1089
BLAST of Rho guanine nucleotide exchange factor vs. Ensembl Fly
Match: Exn (gene:FBgn0261547 transcript:FBtr0302647) HSP 1 Score: 100.908 bits (250), Expect = 2.721e-21 Identity = 117/486 (24.07%), Postives = 194/486 (39.92%), Query Frame = 1
Query: 1009 RLRWAETEEGKKLINMQKLSEDIIKWQEAQFEVITSEASYYRSLEVLVNKIY-KSSWMDCAKEKKNMQDNLSPELDDPPNPFTKPIITATQKHHLFSNILEIHIVSGELLKALESRWRENPLIKDLSDILVDFCSEKLKPYVTYLRNQRFQTDTYNKLLNYPE---FLNIIKKFENDPDCSMMNLCSFLMLPMQRVLRLKLLMTVVKHHIPKGYPT-----DGCDEAIEALEKLIKECSDEKMVMEQKEEILLICNRLIIKDKMNV---------SIGSKP--LLKNGALKVISNNKHASKLLGSSLLNRNNKRAQLYLFEDQLIIAKQRKLPLCVSSDDNREVVVDTCQR--FNVKFVEISPQKPLSRFN--------FKLVLSNGMKGSAEYICSVDNPDDLNEWKNAF------SVNKSRHEEFDFGEAFVICDYTPTSKKEIGLKKGQILNIIKRI-----DNER----AIASFSGKQGEIL 2331
R W+E E + L+ QEA+FE+ITSEASY +SL +L ++++D + +++A + LFS I+ +H S LL LE+ W++N ++ LS + + YV + +Q T +L E F +++ E P C +NL SFLMLPMQR+ RL LL+ V K P + + ++K++ +C++ EQ E+ I +L + G+KP L+K G L + +KL L + + A +LF D L++ K+R C S V D C R + + PQ P +L N + + E + S + D W A + + +E +D + Y + L+ G ++N+ +++ ER A+ F G E L
Sbjct: 573 RTLWSEIPEVIHSCILPTLTSRERSLQEAKFEIITSEASYLKSLNLLRRHFMNHNAFLDSS------------------------VLSAKDRKALFSYIVPVHECSERLLTELEACWQDNIMLLGLSRCIYEIAERHFHVYVAFCEHQGRMDRTLRRLKESKESLAFQQHLERLEASPSCCGLNLHSFLMLPMQRITRLPLLIDAV---FSKESPLNREEYESWKLTLALVQKVVGQCNEAANRWEQAFELERIARQLEFPSHVRALAIAPVGVPRAGAKPRFLVKRGELTHLLWRGEDAKLTFGKRLTKISIYA--FLFSDLLLLCKRRG-ESCFS-------VFDYCPRSMLTLAAGDSLPQLPTKDLKDQAGKNLILMTLLENCDRKTVELVLSCPSVSDQQRWLQAMRPPEAETPGEKLYESWDCPQVVAKHSYESDEPDVLQLELGDVVNVSRKLPDGWYQGERIRDGAVGWFPGSYTEEL 1021
BLAST of Rho guanine nucleotide exchange factor vs. Ensembl Fly
Match: Exn (gene:FBgn0261547 transcript:FBtr0302648) HSP 1 Score: 100.908 bits (250), Expect = 2.721e-21 Identity = 117/486 (24.07%), Postives = 194/486 (39.92%), Query Frame = 1
Query: 1009 RLRWAETEEGKKLINMQKLSEDIIKWQEAQFEVITSEASYYRSLEVLVNKIY-KSSWMDCAKEKKNMQDNLSPELDDPPNPFTKPIITATQKHHLFSNILEIHIVSGELLKALESRWRENPLIKDLSDILVDFCSEKLKPYVTYLRNQRFQTDTYNKLLNYPE---FLNIIKKFENDPDCSMMNLCSFLMLPMQRVLRLKLLMTVVKHHIPKGYPT-----DGCDEAIEALEKLIKECSDEKMVMEQKEEILLICNRLIIKDKMNV---------SIGSKP--LLKNGALKVISNNKHASKLLGSSLLNRNNKRAQLYLFEDQLIIAKQRKLPLCVSSDDNREVVVDTCQR--FNVKFVEISPQKPLSRFN--------FKLVLSNGMKGSAEYICSVDNPDDLNEWKNAF------SVNKSRHEEFDFGEAFVICDYTPTSKKEIGLKKGQILNIIKRI-----DNER----AIASFSGKQGEIL 2331
R W+E E + L+ QEA+FE+ITSEASY +SL +L ++++D + +++A + LFS I+ +H S LL LE+ W++N ++ LS + + YV + +Q T +L E F +++ E P C +NL SFLMLPMQR+ RL LL+ V K P + + ++K++ +C++ EQ E+ I +L + G+KP L+K G L + +KL L + + A +LF D L++ K+R C S V D C R + + PQ P +L N + + E + S + D W A + + +E +D + Y + L+ G ++N+ +++ ER A+ F G E L
Sbjct: 573 RTLWSEIPEVIHSCILPTLTSRERSLQEAKFEIITSEASYLKSLNLLRRHFMNHNAFLDSS------------------------VLSAKDRKALFSYIVPVHECSERLLTELEACWQDNIMLLGLSRCIYEIAERHFHVYVAFCEHQGRMDRTLRRLKESKESLAFQQHLERLEASPSCCGLNLHSFLMLPMQRITRLPLLIDAV---FSKESPLNREEYESWKLTLALVQKVVGQCNEAANRWEQAFELERIARQLEFPSHVRALAIAPVGVPRAGAKPRFLVKRGELTHLLWRGEDAKLTFGKRLTKISIYA--FLFSDLLLLCKRRG-ESCFS-------VFDYCPRSMLTLAAGDSLPQLPTKDLKDQAGKNLILMTLLENCDRKTVELVLSCPSVSDQQRWLQAMRPPEAETPGEKLYESWDCPQVVAKHSYESDEPDVLQLELGDVVNVSRKLPDGWYQGERIRDGAVGWFPGSYTEEL 1021
BLAST of Rho guanine nucleotide exchange factor vs. Ensembl Fly
Match: Exn (gene:FBgn0261547 transcript:FBtr0302649) HSP 1 Score: 100.908 bits (250), Expect = 2.721e-21 Identity = 117/486 (24.07%), Postives = 194/486 (39.92%), Query Frame = 1
Query: 1009 RLRWAETEEGKKLINMQKLSEDIIKWQEAQFEVITSEASYYRSLEVLVNKIY-KSSWMDCAKEKKNMQDNLSPELDDPPNPFTKPIITATQKHHLFSNILEIHIVSGELLKALESRWRENPLIKDLSDILVDFCSEKLKPYVTYLRNQRFQTDTYNKLLNYPE---FLNIIKKFENDPDCSMMNLCSFLMLPMQRVLRLKLLMTVVKHHIPKGYPT-----DGCDEAIEALEKLIKECSDEKMVMEQKEEILLICNRLIIKDKMNV---------SIGSKP--LLKNGALKVISNNKHASKLLGSSLLNRNNKRAQLYLFEDQLIIAKQRKLPLCVSSDDNREVVVDTCQR--FNVKFVEISPQKPLSRFN--------FKLVLSNGMKGSAEYICSVDNPDDLNEWKNAF------SVNKSRHEEFDFGEAFVICDYTPTSKKEIGLKKGQILNIIKRI-----DNER----AIASFSGKQGEIL 2331
R W+E E + L+ QEA+FE+ITSEASY +SL +L ++++D + +++A + LFS I+ +H S LL LE+ W++N ++ LS + + YV + +Q T +L E F +++ E P C +NL SFLMLPMQR+ RL LL+ V K P + + ++K++ +C++ EQ E+ I +L + G+KP L+K G L + +KL L + + A +LF D L++ K+R C S V D C R + + PQ P +L N + + E + S + D W A + + +E +D + Y + L+ G ++N+ +++ ER A+ F G E L
Sbjct: 573 RTLWSEIPEVIHSCILPTLTSRERSLQEAKFEIITSEASYLKSLNLLRRHFMNHNAFLDSS------------------------VLSAKDRKALFSYIVPVHECSERLLTELEACWQDNIMLLGLSRCIYEIAERHFHVYVAFCEHQGRMDRTLRRLKESKESLAFQQHLERLEASPSCCGLNLHSFLMLPMQRITRLPLLIDAV---FSKESPLNREEYESWKLTLALVQKVVGQCNEAANRWEQAFELERIARQLEFPSHVRALAIAPVGVPRAGAKPRFLVKRGELTHLLWRGEDAKLTFGKRLTKISIYA--FLFSDLLLLCKRRG-ESCFS-------VFDYCPRSMLTLAAGDSLPQLPTKDLKDQAGKNLILMTLLENCDRKTVELVLSCPSVSDQQRWLQAMRPPEAETPGEKLYESWDCPQVVAKHSYESDEPDVLQLELGDVVNVSRKLPDGWYQGERIRDGAVGWFPGSYTEEL 1021
BLAST of Rho guanine nucleotide exchange factor vs. Ensembl Fly
Match: Exn (gene:FBgn0261547 transcript:FBtr0302651) HSP 1 Score: 100.138 bits (248), Expect = 7.997e-21 Identity = 110/460 (23.91%), Postives = 186/460 (40.43%), Query Frame = 1
Query: 1009 RLRWAETEEGKKLINMQKLSEDIIKWQEAQFEVITSEASYYRSLEVLVNKIY-KSSWMDCAKEKKNMQDNLSPELDDPPNPFTKPIITATQKHHLFSNILEIHIVSGELLKALESRWRENPLIKDLSDILVDFCSEKLKPYVTYLRNQRFQTDTYNKLLNYPE---FLNIIKKFENDPDCSMMNLCSFLMLPMQRVLRLKLLMTVVKHHIPKGYPT-----DGCDEAIEALEKLIKECSDEKMVMEQKEEILLICNRLIIKDKMNV---------SIGSKP--LLKNGALKVISNNKHASKLLGSSLLNRNNKRAQLYLFEDQLIIAKQRKLPLCVSSDDNREVVVDTCQR--FNVKFVEISPQKPLSRFN--------FKLVLSNGMKGSAEYICSVDNPDDLNEWKNAF------SVNKSRHEEFDFGEAFVICDYTPTSKKEIGLKKGQILNIIKRI 2280
R W+E E + L+ QEA+FE+ITSEASY +SL +L ++++D + +++A + LFS I+ +H S LL LE+ W++N ++ LS + + YV + +Q T +L E F +++ E P C +NL SFLMLPMQR+ RL LL+ V K P + + ++K++ +C++ EQ E+ I +L + G+KP L+K G L + +KL L + + A +LF D L++ K+R C S V D C R + + PQ P +L N + + E + S + D W A + + +E +D + Y + L+ G ++N+ +++
Sbjct: 1551 RTLWSEIPEVIHSCILPTLTSRERSLQEAKFEIITSEASYLKSLNLLRRHFMNHNAFLDSS------------------------VLSAKDRKALFSYIVPVHECSERLLTELEACWQDNIMLLGLSRCIYEIAERHFHVYVAFCEHQGRMDRTLRRLKESKESLAFQQHLERLEASPSCCGLNLHSFLMLPMQRITRLPLLIDAV---FSKESPLNREEYESWKLTLALVQKVVGQCNEAANRWEQAFELERIARQLEFPSHVRALAIAPVGVPRAGAKPRFLVKRGELTHLLWRGEDAKLTFGKRLTKISIYA--FLFSDLLLLCKRRG-ESCFS-------VFDYCPRSMLTLAAGDSLPQLPTKDLKDQAGKNLILMTLLENCDRKTVELVLSCPSVSDQQRWLQAMRPPEAETPGEKLYESWDCPQVVAKHSYESDEPDVLQLELGDVVNVSRKL 1973
BLAST of Rho guanine nucleotide exchange factor vs. Ensembl Fly
Match: Exn (gene:FBgn0261547 transcript:FBtr0302650) HSP 1 Score: 100.138 bits (248), Expect = 7.997e-21 Identity = 110/460 (23.91%), Postives = 186/460 (40.43%), Query Frame = 1
Query: 1009 RLRWAETEEGKKLINMQKLSEDIIKWQEAQFEVITSEASYYRSLEVLVNKIY-KSSWMDCAKEKKNMQDNLSPELDDPPNPFTKPIITATQKHHLFSNILEIHIVSGELLKALESRWRENPLIKDLSDILVDFCSEKLKPYVTYLRNQRFQTDTYNKLLNYPE---FLNIIKKFENDPDCSMMNLCSFLMLPMQRVLRLKLLMTVVKHHIPKGYPT-----DGCDEAIEALEKLIKECSDEKMVMEQKEEILLICNRLIIKDKMNV---------SIGSKP--LLKNGALKVISNNKHASKLLGSSLLNRNNKRAQLYLFEDQLIIAKQRKLPLCVSSDDNREVVVDTCQR--FNVKFVEISPQKPLSRFN--------FKLVLSNGMKGSAEYICSVDNPDDLNEWKNAF------SVNKSRHEEFDFGEAFVICDYTPTSKKEIGLKKGQILNIIKRI 2280
R W+E E + L+ QEA+FE+ITSEASY +SL +L ++++D + +++A + LFS I+ +H S LL LE+ W++N ++ LS + + YV + +Q T +L E F +++ E P C +NL SFLMLPMQR+ RL LL+ V K P + + ++K++ +C++ EQ E+ I +L + G+KP L+K G L + +KL L + + A +LF D L++ K+R C S V D C R + + PQ P +L N + + E + S + D W A + + +E +D + Y + L+ G ++N+ +++
Sbjct: 1551 RTLWSEIPEVIHSCILPTLTSRERSLQEAKFEIITSEASYLKSLNLLRRHFMNHNAFLDSS------------------------VLSAKDRKALFSYIVPVHECSERLLTELEACWQDNIMLLGLSRCIYEIAERHFHVYVAFCEHQGRMDRTLRRLKESKESLAFQQHLERLEASPSCCGLNLHSFLMLPMQRITRLPLLIDAV---FSKESPLNREEYESWKLTLALVQKVVGQCNEAANRWEQAFELERIARQLEFPSHVRALAIAPVGVPRAGAKPRFLVKRGELTHLLWRGEDAKLTFGKRLTKISIYA--FLFSDLLLLCKRRG-ESCFS-------VFDYCPRSMLTLAAGDSLPQLPTKDLKDQAGKNLILMTLLENCDRKTVELVLSCPSVSDQQRWLQAMRPPEAETPGEKLYESWDCPQVVAKHSYESDEPDVLQLELGDVVNVSRKL 1973
BLAST of Rho guanine nucleotide exchange factor vs. Ensembl Zebrafish
Match: arhgef15 (Rho guanine nucleotide exchange factor (GEF) 15 [Source:ZFIN;Acc:ZDB-GENE-060526-292]) HSP 1 Score: 140.969 bits (354), Expect = 1.174e-34 Identity = 119/439 (27.11%), Postives = 212/439 (48.29%), Query Frame = 1
Query: 1054 MQKLSEDIIKWQEAQFEVITSEASYYRSLEVLVNKIYKSSWMDCAKEKKNMQDNLSPELDDPPNPFTKPIITATQKHHLFSNILEIHIVSGELLKALESRWRENPLIKDLSDILVDFCSEKLKPYVTYLRNQRFQTDTYNKLL-NYPEFLNIIKKFENDPDCSMMNLCSFLMLPMQRVLRLKLLMTVVKHHIPKGYP-TDGCDEAIEALEKLIKECSDEKMVMEQKEEILLICNRLIIKDKMNVSIGSKP--LLKNGALKVISNNKHASKLLGSSLLNRNNKRAQLY--LFEDQLIIAKQRKLPLCVSSDDNREVVVDTCQRFNVKF-VEISPQKPLSRFNFKLVLSNGMKGSA-EYICSVDNPDDLNEWKNAF-SVNKSRHEE-----FDFGEAFVICDYTPTSKKEIGLKKGQILNIIKRIDNE--RAIASFSGKQG 2322
+ KL+ + QE+ FEV+TSEASY RSL VL + S EL++ + + LFSN+L+++ VS ++ L R E+ +I D+SDI+ + Y+ Y+RNQ++Q TY+KL+ + +F ++++ E P C + SF++LP QR+ R+K+L+ ++ KG + +A+ ++ KLI + + + M+Q EE++ N+L + I SK L K+G L+ +S SL + N+ + +Y LF D LI+ ++ S +R V+D R V+ ++ P F L L +GS E++ + D++ W AF S+N++ EE +D + + Y E+ L+ +++N++++ + I F GK+G
Sbjct: 81 LHKLTRTEKQRQESMFEVLTSEASYLRSLRVLKDHFLGSR-----------------ELNET--------LVIHDRKVLFSNLLQVYEVSERFIRDLLKRVDESVVISDVSDIIYEHSENHFSVYIDYVRNQQYQEKTYSKLMESNTDFAVVMRRLELSPLCKRLPFTSFMLLPFQRITRIKILIQSIQKRTAKGTKEEETASKALTSVSKLITQANQQVGQMKQMEELINTSNKLEFDKVKVIPIVSKTRCLEKHGELQELSKR--------GSLFSMRNRCSPVYMFLFNDLLILTTRK------SGCPDRFTVIDYAHRSLVQVQATVNSLGPHLDHCFSLTLLENHRGSTCEHLLKANTESDMHRWIAAFPSINETFGEEKIYEDWDCPQVQCVDRYVAQQADELSLEVSEVINVLRKTNEGWYEGIRLFDGKKG 480
BLAST of Rho guanine nucleotide exchange factor vs. Ensembl Zebrafish
Match: arhgef15 (Rho guanine nucleotide exchange factor (GEF) 15 [Source:ZFIN;Acc:ZDB-GENE-060526-292]) HSP 1 Score: 142.895 bits (359), Expect = 3.481e-34 Identity = 121/451 (26.83%), Postives = 216/451 (47.89%), Query Frame = 1
Query: 1018 WAETEEGKKLINMQKLSEDIIKWQEAQFEVITSEASYYRSLEVLVNKIYKSSWMDCAKEKKNMQDNLSPELDDPPNPFTKPIITATQKHHLFSNILEIHIVSGELLKALESRWRENPLIKDLSDILVDFCSEKLKPYVTYLRNQRFQTDTYNKLL-NYPEFLNIIKKFENDPDCSMMNLCSFLMLPMQRVLRLKLLMTVVKHHIPKGYP-TDGCDEAIEALEKLIKECSDEKMVMEQKEEILLICNRLIIKDKMNVSIGSKP--LLKNGALKVISNNKHASKLLGSSLLNRNNKRAQLY--LFEDQLIIAKQRKLPLCVSSDDNREVVVDTCQRFNVKF-VEISPQKPLSRFNFKLVLSNGMKGSA-EYICSVDNPDDLNEWKNAF-SVNKSRHEE-----FDFGEAFVICDYTPTSKKEIGLKKGQILNIIKRIDNE--RAIASFSGKQG 2322
W + K+ + KL+ + QE+ FEV+TSEASY RSL VL + S EL++ + + LFSN+L+++ VS ++ L R E+ +I D+SDI+ + Y+ Y+RNQ++Q TY+KL+ + +F ++++ E P C + SF++LP QR+ R+K+L+ ++ KG + +A+ ++ KLI + + + M+Q EE++ N+L + I SK L K+G L+ +S SL + N+ + +Y LF D LI+ ++ S +R V+D R V+ ++ P F L L +GS E++ + D++ W AF S+N++ EE +D + + Y E+ L+ +++N++++ + I F GK+G
Sbjct: 470 WQDLPVVKESGMLHKLTRTEKQRQESMFEVLTSEASYLRSLRVLKDHFLGSR-----------------ELNE--------TLVIHDRKVLFSNLLQVYEVSERFIRDLLKRVDESVVISDVSDIIYEHSENHFSVYIDYVRNQQYQEKTYSKLMESNTDFAVVMRRLELSPLCKRLPFTSFMLLPFQRITRIKILIQSIQKRTAKGTKEEETASKALTSVSKLITQANQQVGQMKQMEELINTSNKLEFDKVKVIPIVSKTRCLEKHGELQELSKR--------GSLFSMRNRCSPVYMFLFNDLLILTTRK------SGCPDRFTVIDYAHRSLVQVQATVNSLGPHLDHCFSLTLLENHRGSTCEHLLKANTESDMHRWIAAFPSINETFGEEKIYEDWDCPQVQCVDRYVAQQADELSLEVSEVINVLRKTNEGWYEGIRLFDGKKG 881
BLAST of Rho guanine nucleotide exchange factor vs. Ensembl Zebrafish
Match: arhgef16 (Rho guanine nucleotide exchange factor (GEF) 16 [Source:ZFIN;Acc:ZDB-GENE-081104-446]) HSP 1 Score: 136.346 bits (342), Expect = 8.304e-33 Identity = 126/434 (29.03%), Postives = 202/434 (46.54%), Query Frame = 1
Query: 1012 LRWAETEEGKKLINMQKLSEDIIKWQEAQFEVITSEASYYRSLEVLVNKIYKSSWMDCAKEKKNMQDNLSPELDDPPNPFTKPIITATQKHHLFSNILEIHIVSGELLKALESRWRENPLIKDLSDILVDFCSEKLKPYVTYLRNQRFQTDTYNKLLNY-PEFLNIIKKFENDPDCSMMNLCSFLMLPMQRVLRLKLLMTVVKHHIPKGYPT--DGCDEAIEALEKLIKECSDEKMVMEQKEEILLICNRL---IIKDKMNVSIGSKPLLKNGALKVISNNKHASKLLGSSLLNRNNKRAQLYLFEDQLIIAKQRKLPLCVSSDDNREVVVDTCQRFNVKFVEISPQKPLSRFNFKLVLSNGMKGSAEYICSV-DNPDDLNEWKNAFSVNK--SRHEEFDFGEAFVICDYTPTSKKEIGLKKGQILNIIKRIDN 2286
+ W++ + K L + ++ + K QE FE+ITSE SY SL +LV + D +K M TAT+ HHLFSNI I VS + L+ R + NP+I+ +SDI+ + ++ +PY+ Y N+ FQ T KLL+ F +K+ E DC + + SFL+LPMQRV RL LLM + K C A +A+ KL+K C+D ME+ E++ I ++ IK VS S+ L K+G L V +++ + S K L+LF D LI+ K++ + VV+D V+ E S+ N KL+++ G +E + V +N +W A K S + D + Y P + E+ L++ +++ +I+ ++
Sbjct: 210 ITWSQLPQVKDLGILDFITPEERKRQEVIFEIITSEYSYQHSLSILVRH-----FKDSVDLRKTM--------------------TATEHHHLFSNISVIQDVSKRFFEDLDKRHQANPVIERISDIVATYATKHFEPYIVYCSNETFQQRTLQKLLSSNSAFRETLKQIETSEDCGGLPMLSFLILPMQRVTRLPLLMDTICEKTTKETAEYYKAC-WAFKAISKLVKSCNDGARRMERTEQMYTIQKQMEFGKIKPFPLVS-SSRWLKKSGELAVYTDDLSIFRKAFS------FKSYYLFLFNDVLIVTKKK--------SEESYVVLDYATVEKVEVEEEMSD---SKLNLKLMMNPNSDGRSEQLVLVAENKLVRAQWVTALRDVKQTSSIDNDDLPQYEATKAYLPKAPDELSLQQAEVVIVIQEVEG 599
BLAST of Rho guanine nucleotide exchange factor vs. Ensembl Zebrafish
Match: arhgef16 (Rho guanine nucleotide exchange factor (GEF) 16 [Source:ZFIN;Acc:ZDB-GENE-081104-446]) HSP 1 Score: 132.88 bits (333), Expect = 1.286e-31 Identity = 103/315 (32.70%), Postives = 155/315 (49.21%), Query Frame = 1
Query: 1012 LRWAETEEGKKLINMQKLSEDIIKWQEAQFEVITSEASYYRSLEVLVNKIYKSSWMDCAKEKKNMQDNLSPELDDPPNPFTKPIITATQKHHLFSNILEIHIVSGELLKALESRWRENPLIKDLSDILVDFCSEKLKPYVTYLRNQRFQTDTYNKLLNY-PEFLNIIKKFENDPDCSMMNLCSFLMLPMQRVLRLKLLMTVVKHHIPKGYPT--DGCDEAIEALEKLIKECSDEKMVMEQKEEILLICNRL---IIKDKMNVSIGSKPLLKNGALKVISNNKHASKLLGSSLLNRNNKRAQLYLFEDQLIIAKQR 1938
+ W++ + K L + ++ + K QE FE+ITSE SY SL +LV + D +K M TAT+ HHLFSNI I VS + L+ R + NP+I+ +SDI+ + ++ +PY+ Y N+ FQ T KLL+ F +K+ E DC + + SFL+LPMQRV RL LLM + K C A +A+ KL+K C+D ME+ E++ I ++ IK VS S+ L K+G L V +++ + S K L+LF D LI+ K++
Sbjct: 210 ITWSQLPQVKDLGILDFITPEERKRQEVIFEIITSEYSYQHSLSILVRH-----FKDSVDLRKTM--------------------TATEHHHLFSNISVIQDVSKRFFEDLDKRHQANPVIERISDIVATYATKHFEPYIVYCSNETFQQRTLQKLLSSNSAFRETLKQIETSEDCGGLPMLSFLILPMQRVTRLPLLMDTICEKTTKETAEYYKAC-WAFKAISKLVKSCNDGARRMERTEQMYTIQKQMEFGKIKPFPLVS-SSRWLKKSGELAVYTDDLSIFRKAFS------FKSYYLFLFNDVLIVTKKK 491
BLAST of Rho guanine nucleotide exchange factor vs. Ensembl Zebrafish
Match: arhgef19 (Rho guanine nucleotide exchange factor (GEF) 19 [Source:ZFIN;Acc:ZDB-GENE-090313-243]) HSP 1 Score: 126.331 bits (316), Expect = 5.311e-30 Identity = 109/410 (26.59%), Postives = 184/410 (44.88%), Query Frame = 1
Query: 1081 KWQEAQFEVITSEASYYRSLEVLVNKIYKSSWM-DCAKEKKNMQDNLSPELDDPPNPFTKPIITATQKHHLFSNILEIHIVSGELLKALESRWRENPLIKDLSDILVDFCSEKLKPYVTYLRNQRFQTDTYNKLLNY-PEFLNIIKKFENDPDCSMMNLCSFLMLPMQRVLRLKLLM-TVVKHHIPKGYPTDGCDEAIEALEKLIKECSDEKMVMEQKEEILLICNRLIIKDKMNVSIG-SKPLLKNGALKVISNNKHASKLLGSSLLNRNNKRAQLYLFEDQLIIAKQR---KLPLCVSSDDNREVVVDTCQRFNVKFVEISPQKPLSRFNFKLVLSNGMKGSAEYICSVDNPDDLNEWKNAF------SVNKSRHEEFDFGEAFVICDYTPTSKKEIGLKKGQILNII 2271
K QEA+FE++TSEASY RSL + V+ SS + +C + ++ LFS + ++ VS L+ LE R + L D+ DI++D C + Y+ Y+ NQ +Q TY +LL F I+ + E DP C + L SFL+LP QR+ RLK+L+ ++K P D +A+ L+K+IKEC+ M++ EE++ + ++ + K+ I S+ L+K+G L + + + S + L+LF D L++++++ K + V + V D Q+ + +S F F L L G + + + W A + + +E D + I Y E+ L+K IL +
Sbjct: 72 KLQEAKFELVTSEASYIRSLSIAVDHFMMSSELCEC--------------------------LGTQERQWLFSKLPDVKEVSERFLQDLERRLEGDILRFDVCDIVLDHCPALRRVYLPYVTNQAYQEQTYQRLLQENARFPGILARLEEDPICQRLPLTSFLILPFQRITRLKMLVENILKRTTPGSRDEDTATKALNELKKIIKECNSSVQSMKRMEELIHLNKKIHFEGKIFPLISQSRWLVKHGELLEVDTQNLS---ISGSKFKLTTRPVYLHLFNDCLLLSRRKESWKFMVFVHAKIEDLKVKDLSQKL----------QGISGFIFYLQLCEGQQLKHQILLKSPTESSKQRWITAMFPSDPTTAIEQTNENDDLSQVQCIRSYQAQEHDELTLEKADILQAV 442
BLAST of Rho guanine nucleotide exchange factor vs. Ensembl Xenopus
Match: arhgef16 (Rho guanine nucleotide exchange factor 16 [Source:NCBI gene;Acc:549614]) HSP 1 Score: 151.754 bits (382), Expect = 3.527e-37 Identity = 135/475 (28.42%), Postives = 217/475 (45.68%), Query Frame = 1
Query: 1009 RLRWAETEEGKKLINMQKLSEDIIKWQEAQFEVITSEASYYRSLEVLVNKIYKSSWMDCAKEKKNMQDNLSPELDDPPNPFTKPIITATQKHHLFSNILEIHIVSGELLKALESRWRENPLIKDLSDILVDFCSEKLKPYVTYLRNQRFQTDTYNKLLNY-PEFLNIIKKFENDPDCSMMNLCSFLMLPMQRVLRLKLLMTVVKHHIPKGYPTDG-CDEAIEALEKLIKECSDEKMVMEQKEEILLICNRL---IIKDKMNVSIGSKPLLKNGALKVISNNKHASKLLGSSLLNRNNKRAQLYLFEDQLIIAKQRKLPLCVSSDDNREVVVDTCQRFNVKFVE--------------ISPQKPLSRFNFKLVLSNGMKGSA-EYICSVDNPDDLNEWKNAFSVNK-----SRHEEFDFGEAFVICDYTPTSKKEIGLKKGQILNIIKRIDNERAIASF-SGKQGEILLSCVQYVS 2355
+L W++ E ++ + K+S + K QEA FE+ITSE SY SL +LV KS + K IT T+ HHLFSNI EI VS + LE R +ENP I ++SDI+ K +PYV+Y N+ +Q T +L++ F + +K+ E +C + + SFL+LPMQRV RL LLM + + G A++AL KL+K+C++ ME+ E++ + +L IK +S S+ LLK G L ++ + K G + L+LF D LII K++ + +D V++D +F V +E P+ P F F++ +S +G E + + D+ D W A + SR + +I Y EI L++ ++ +++ D G++G SC + ++
Sbjct: 259 QLIWSQLPEVQESGILNKISPEERKRQEAIFEIITSEYSYQHSLGILVRLFKKSEEL-------------------------KQTITNTEHHHLFSNIAEIQEVSKRFFEDLEKRHKENPFIDNISDIVEHHAQNKFQPYVSYCSNEMYQQRTLQRLMSTNGTFKDTLKQIEMKAECGGLPMFSFLILPMQRVTRLPLLMDTICQKMDMRTKEYGETTHALKALSKLVKQCNEGARKMERTEQMYTLQTQLEFGKIKPFPLIS-ASRWLLKRGELNLVEESGVFWKGFGKT-------SCYLFLFNDILIITKKKSEENYIVTD---YVMMD---QFAVAKIENGDPQLSPPAKTGTSGPRSPNGPFLFQIHISKNSEGKQDEIVLAADSLSDRARWVAALERKEDNKENSRSRRGGLRQVEIIKAYLAKQADEISLQQADVMLVLQEEDGWYQGERLRDGERGWFPESCAKEIT 694
BLAST of Rho guanine nucleotide exchange factor vs. Ensembl Xenopus
Match: arhgef16 (Rho guanine nucleotide exchange factor 16 [Source:NCBI gene;Acc:549614]) HSP 1 Score: 151.369 bits (381), Expect = 4.071e-37 Identity = 135/475 (28.42%), Postives = 217/475 (45.68%), Query Frame = 1
Query: 1009 RLRWAETEEGKKLINMQKLSEDIIKWQEAQFEVITSEASYYRSLEVLVNKIYKSSWMDCAKEKKNMQDNLSPELDDPPNPFTKPIITATQKHHLFSNILEIHIVSGELLKALESRWRENPLIKDLSDILVDFCSEKLKPYVTYLRNQRFQTDTYNKLLNY-PEFLNIIKKFENDPDCSMMNLCSFLMLPMQRVLRLKLLMTVVKHHIPKGYPTDG-CDEAIEALEKLIKECSDEKMVMEQKEEILLICNRL---IIKDKMNVSIGSKPLLKNGALKVISNNKHASKLLGSSLLNRNNKRAQLYLFEDQLIIAKQRKLPLCVSSDDNREVVVDTCQRFNVKFVE--------------ISPQKPLSRFNFKLVLSNGMKGSA-EYICSVDNPDDLNEWKNAFSVNK-----SRHEEFDFGEAFVICDYTPTSKKEIGLKKGQILNIIKRIDNERAIASF-SGKQGEILLSCVQYVS 2355
+L W++ E ++ + K+S + K QEA FE+ITSE SY SL +LV KS + K IT T+ HHLFSNI EI VS + LE R +ENP I ++SDI+ K +PYV+Y N+ +Q T +L++ F + +K+ E +C + + SFL+LPMQRV RL LLM + + G A++AL KL+K+C++ ME+ E++ + +L IK +S S+ LLK G L ++ + K G + L+LF D LII K++ + +D V++D +F V +E P+ P F F++ +S +G E + + D+ D W A + SR + +I Y EI L++ ++ +++ D G++G SC + ++
Sbjct: 244 QLIWSQLPEVQESGILNKISPEERKRQEAIFEIITSEYSYQHSLGILVRLFKKSEEL-------------------------KQTITNTEHHHLFSNIAEIQEVSKRFFEDLEKRHKENPFIDNISDIVEHHAQNKFQPYVSYCSNEMYQQRTLQRLMSTNGTFKDTLKQIEMKAECGGLPMFSFLILPMQRVTRLPLLMDTICQKMDMRTKEYGETTHALKALSKLVKQCNEGARKMERTEQMYTLQTQLEFGKIKPFPLIS-ASRWLLKRGELNLVEESGVFWKGFGKT-------SCYLFLFNDILIITKKKSEENYIVTD---YVMMD---QFAVAKIENGDPQLSPPAKTGTSGPRSPNGPFLFQIHISKNSEGKQDEIVLAADSLSDRARWVAALERKEDNKENSRSRRGGLRQVEIIKAYLAKQADEISLQQADVMLVLQEEDGWYQGERLRDGERGWFPESCAKEIT 679
BLAST of Rho guanine nucleotide exchange factor vs. Ensembl Xenopus
Match: arhgef16 (Rho guanine nucleotide exchange factor 16 [Source:NCBI gene;Acc:549614]) HSP 1 Score: 150.214 bits (378), Expect = 1.044e-36 Identity = 135/469 (28.78%), Postives = 216/469 (46.06%), Query Frame = 1
Query: 1009 RLRWAETEEGKKLINMQKLSEDIIKWQEAQFEVITSEASYYRSLEVLVNKIYKSSWMDCAKEKKNMQDNLSPELDDPPNPFTKPIITATQKHHLFSNILEIHIVSGELLKALESRWRENPLIKDLSDILVDFCSEKLKPYVTYLRNQRFQTDTYNKLLNYPEFLNIIKKFENDPDCSMMNLCSFLMLPMQRVLRLKLLMTVVKHHIPKGYPTDG-CDEAIEALEKLIKECSDEKMVMEQKEEILLICNRL---IIKDKMNVSIGSKPLLKNGALKVISNNKHASKLLGSSLLNRNNKRAQLYLFEDQLIIAKQRKLPLCVSSDDNREVVVDTCQRFNVKFVE--------------ISPQKPLSRFNFKLVLSNGMKGSA-EYICSVDNPDDLNEWKNAFSVNKSRHEEFDFGEAFVICDYTPTSKKEIGLKKGQILNIIKRIDNERAIASF-SGKQGEILLSCVQYVS 2355
+L W++ E ++ + K+S + K QEA FE+ITSE SY SL +LV KS + K IT T+ HHLFSNI EI VS + LE R +ENP I ++SDI+ K +PYV+Y N+ +Q T + N F + +K+ E +C + + SFL+LPMQRV RL LLM + + G A++AL KL+K+C++ ME+ E++ + +L IK +S S+ LLK G L ++ + K G + L+LF D LII K++ + +D V++D +F V +E P+ P F F++ +S +G E + + D+ D W A K ++E + +I Y EI L++ ++ +++ D G++G SC + ++
Sbjct: 255 QLIWSQLPEVQESGILNKISPEERKRQEAIFEIITSEYSYQHSLGILVRLFKKSEEL-------------------------KQTITNTEHHHLFSNIAEIQEVSKRFFEDLEKRHKENPFIDNISDIVEHHAQNKFQPYVSYCSNEMYQQRTLQRSTN-GTFKDTLKQIEMKAECGGLPMFSFLILPMQRVTRLPLLMDTICQKMDMRTKEYGETTHALKALSKLVKQCNEGARKMERTEQMYTLQTQLEFGKIKPFPLIS-ASRWLLKRGELNLVEESGVFWKGFGKT-------SCYLFLFNDILIITKKKSEENYIVTD---YVMMD---QFAVAKIENGDPQLSPPAKTGTSGPRSPNGPFLFQIHISKNSEGKQDEIVLAADSLSDRARWVAALE-RKEDNKENRLRQVEIIKAYLAKQADEISLQQADVMLVLQEEDGWYQGERLRDGERGWFPESCAKEIT 682
BLAST of Rho guanine nucleotide exchange factor vs. Ensembl Xenopus
Match: NGEF (neuronal guanine nucleotide exchange factor [Source:NCBI gene;Acc:100487663]) HSP 1 Score: 148.288 bits (373), Expect = 1.460e-36 Identity = 128/476 (26.89%), Postives = 214/476 (44.96%), Query Frame = 1
Query: 892 QERTTTRDEDNDSIELEPNIDNDSFADNRVFQLFSATSQRLR-WAETEEGKKLINMQKLSEDIIKWQEAQFEVITSEASYYRSLEVLVNKIYKSSWMDCAKEKKNMQDNLSPELDDPPNPFTKPIITATQKHHLFSNILEIHIVSGELLKALESRWRENPLIKDLSDILVDFCSEKLKPYVTYLRNQRFQTDTYNKLLN-YPEFLNIIKKFENDPDCSMMNLCSFLMLPMQRVLRLKLLMTVVKHHIPKGYPTD-GCDEAIEALEKLIKECSDEKMVMEQKEEILLICNRLIIKDK-MNVSIGSKPLLKNGALKVISNNKHASKLLGSSLLNRNNKRAQLYLFEDQLIIAKQRKLPLCVSSDDNREVVVDTCQRFNVKFVEISPQ-KPLSRFNFKLVLSNGMKGSAEYICSVDNPDDLNEWKNAFSVNKSRH------EEFDFGEAFVICDYTPTSKKEIGLKKGQILNIIKRIDN 2286
Q T+ + N + P I+N N F F ++ W + + +K + L + +K QEA FE++TSEASYY+SL ++V S +MD + + ++ ++ H +FSN+LE+ S L ALE R+ EN +I D+ DI+ + + YVTY+ NQ +Q Y KLL PEF + E DP C + SFL+LP QR+ RLKLL+ + + +G + +A LEKL++ C+D M + E+++ I L K K + + S+ L+K G L+ +S + + L L + L+LF D L++ K PL R V D R ++ E+ Q + L+ +L N + Y+ + ++ W + N+ + D + + Y E+ L ILN++ + ++
Sbjct: 103 QSAETSNNSQNTPLGSPPPIENQR--ANSTFSRFESSCSGFNLWQDLPDVRKSGVLALLQPEEVKLQEAMFELLTSEASYYKSLRLVV-----SHFMDSERLRASLHQ--------------------SEIHFIFSNVLEVLATSERFLLALEQRFEENIVISDVCDIVYEHAEKHFVVYVTYVCNQTYQERAYRKLLQERPEFRESVGHLETDPVCRGLPFSSFLILPFQRITRLKLLVQNILTKVEEGSEREVSALQAHRELEKLVRACNDGVRKMSRTEQLISIEKTLEFKIKSVPIISHSRWLMKQGELQQMSGPRTSRTLRTKKLF----RPVYLFLFNDLLLMCK----PLT----GERYQVFDVAARGLLRVEELEDQGQTLANVFILKLLENAHEREFTYMLKATSQSEMKRWMTSLVPNRRTKFVSMSAKLLDCPQVQCVHPYVSQEPDELSLDLADILNVLDKTED 539
BLAST of Rho guanine nucleotide exchange factor vs. Ensembl Xenopus
Match: NGEF (neuronal guanine nucleotide exchange factor [Source:NCBI gene;Acc:100487663]) HSP 1 Score: 148.673 bits (374), Expect = 2.873e-36 Identity = 130/478 (27.20%), Postives = 215/478 (44.98%), Query Frame = 1
Query: 892 QERTTTRDEDNDSIELEPNIDNDSFADNRVFQLFSATSQRLR-WAETEEGKKLINMQKLSEDIIKWQEAQFEVITSEASYYRSLEVLVNKIYKSSWMDCAKEKKNMQDNLSPELDDPPNPFTKPIITATQKHHLFSNILEIHIVSGELLKALESRWRENPLIKDLSDILVDFCSEKLKPYVTYLRNQRFQTDTYNKLLN-YPEFLNIIKKFENDPDCSMMNLCSFLMLPMQRVLRLKLLMTVVKHHIPKGYPTD-GCDEAIEALEKLIKECSDEKMVMEQKEEILLICNRLIIKDK-MNVSIGSKPLLKNGALKVISNNKHASKLLGSSLLNRNNKRAQLYLFEDQLIIAKQRKLPLCVSSDDNREVVVDTCQRFNVKFVEISPQ-KPLSRFNFKLVLSNGMKGSAEYICSVDNPDDLNEWKNAFSVNKSRHEEF--------DFGEAFVICDYTPTSKKEIGLKKGQILNIIKRIDN 2286
Q T+ + N + P I+N N F F ++ W + + +K + L + +K QEA FE++TSEASYY+SL ++V S +MD + + ++ ++ H +FSN+LE+ S L ALE R+ EN +I D+ DI+ + + YVTY+ NQ +Q Y KLL PEF + E DP C + SFL+LP QR+ RLKLL+ + + +G + +A LEKL++ C+D M + E+++ I L K K + + S+ L+K G L+ +S + + L L + L+LF D L++ K PL R V D R ++ E+ Q + L+ +L N + Y+ + ++ W + N R +F D + + Y E+ L ILN++ + ++
Sbjct: 194 QSAETSNNSQNTPLGSPPPIENQR--ANSTFSRFESSCSGFNLWQDLPDVRKSGVLALLQPEEVKLQEAMFELLTSEASYYKSLRLVV-----SHFMDSERLRASLHQ--------------------SEIHFIFSNVLEVLATSERFLLALEQRFEENIVISDVCDIVYEHAEKHFVVYVTYVCNQTYQERAYRKLLQERPEFRESVGHLETDPVCRGLPFSSFLILPFQRITRLKLLVQNILTKVEEGSEREVSALQAHRELEKLVRACNDGVRKMSRTEQLISIEKTLEFKIKSVPIISHSRWLMKQGELQQMSGPRTSRTLRTKKLF----RPVYLFLFNDLLLMCK----PLT----GERYQVFDVAARGLLRVEELEDQGQTLANVFILKLLENAHEREFTYMLKATSQSEMKRWMTSLVPN--RRTKFVSMSAKLLDCPQVQCVHPYVSQEPDELSLDLADILNVLDKTED 630
BLAST of Rho guanine nucleotide exchange factor vs. Ensembl Mouse
Match: Ngef (neuronal guanine nucleotide exchange factor [Source:MGI Symbol;Acc:MGI:1858414]) HSP 1 Score: 150.599 bits (379), Expect = 5.037e-37 Identity = 120/419 (28.64%), Postives = 203/419 (48.45%), Query Frame = 1
Query: 1063 LSEDIIKWQEAQFEVITSEASYYRSLEVLVNKIYKSSWMDCAKEKKNMQDNLSPELDDPPNPFTKPIITATQKHHLFSNILEIHIVSGELLKALESRWRENPLIKDLSDILVDFCSEKLKPYVTYLRNQRFQTDTYNKLLN-YPEFLNIIKKFENDPDCSMMNLCSFLMLPMQRVLRLKLLMTVVKHHIPKGYPTDGCD-EAIEALEKLIKECSDEKMVMEQKEEILLICNRLIIKDK-MNVSIGSKPLLKNGALKVISNNKHASKLLGSSLLNRNNKRAQLYLFEDQLIIAKQRKLPLCVSSDDNREVVVDTCQRFNVKFVEISPQ-KPLSRFNFKLVLSNGMKGSAEYICSVDNPDDLNEWKNAFSVNKSRHEEFDFGEAFVIC-------DYTPTSKKEIGLKKGQILNIIKRIDN 2286
L + I+ QEA FE++TSEASYY+SL +LV S +M+ + KK I+ ++ H LFSN+L++ VS L LE R EN +I D+ DI+ + ++ Y+TY+ NQ +Q TY +LL F +I + E DP C + SFL+LP QR+ RLKLL+ + + + +G +A + LE ++K C++ M + E+++ I ++ K K + + S+ LLK G L+ +S K + L L + L+LF D L+I +Q +P ++ V D+ R ++ E+ Q + L+ +L N A Y+ + ++ W + + N+ R + F + C Y E+ L+ ILNI+++ ++
Sbjct: 267 LQPEEIRLQEAMFELVTSEASYYKSLNLLV-----SHFMENERLKK--------------------ILHPSEAHILFSNVLDVMAVSERFLLELEHRMEENIVISDVCDIVYRYAADHFSVYITYVSNQTYQERTYKQLLQEKAAFRELIAQLELDPKCKGLPFSSFLILPFQRITRLKLLVQNILKRVEERSEREGTALDAHKELEMVVKACNEGVRKMSRTEQMISIQKKMEFKIKSVPIISHSRWLLKQGELQQMSGPKTSRTLRTKKLF----REIYLFLFNDLLVICRQ--IP------GDKYQVFDSAPRGLLRVEELEDQGQTLANVFILRLLENADDREATYMLKASSQSEMKRWMTSLAPNR-RTKFVSFTSRLLDCPQVQCVHPYVAQQPDELTLELADILNILEKTED 647
BLAST of Rho guanine nucleotide exchange factor vs. Ensembl Mouse
Match: Ngef (neuronal guanine nucleotide exchange factor [Source:MGI Symbol;Acc:MGI:1858414]) HSP 1 Score: 149.828 bits (377), Expect = 5.061e-37 Identity = 119/414 (28.74%), Postives = 201/414 (48.55%), Query Frame = 1
Query: 1078 IKWQEAQFEVITSEASYYRSLEVLVNKIYKSSWMDCAKEKKNMQDNLSPELDDPPNPFTKPIITATQKHHLFSNILEIHIVSGELLKALESRWRENPLIKDLSDILVDFCSEKLKPYVTYLRNQRFQTDTYNKLLN-YPEFLNIIKKFENDPDCSMMNLCSFLMLPMQRVLRLKLLMTVVKHHIPKGYPTDGCD-EAIEALEKLIKECSDEKMVMEQKEEILLICNRLIIKDK-MNVSIGSKPLLKNGALKVISNNKHASKLLGSSLLNRNNKRAQLYLFEDQLIIAKQRKLPLCVSSDDNREVVVDTCQRFNVKFVEISPQ-KPLSRFNFKLVLSNGMKGSAEYICSVDNPDDLNEWKNAFSVNKSRHEEFDFGEAFVIC-------DYTPTSKKEIGLKKGQILNIIKRIDN 2286
I+ QEA FE++TSEASYY+SL +LV S +M+ + KK I+ ++ H LFSN+L++ VS L LE R EN +I D+ DI+ + ++ Y+TY+ NQ +Q TY +LL F +I + E DP C + SFL+LP QR+ RLKLL+ + + + +G +A + LE ++K C++ M + E+++ I ++ K K + + S+ LLK G L+ +S K + L L + L+LF D L+I +Q +P ++ V D+ R ++ E+ Q + L+ +L N A Y+ + ++ W + + N+ R + F + C Y E+ L+ ILNI+++ ++
Sbjct: 182 IRLQEAMFELVTSEASYYKSLNLLV-----SHFMENERLKK--------------------ILHPSEAHILFSNVLDVMAVSERFLLELEHRMEENIVISDVCDIVYRYAADHFSVYITYVSNQTYQERTYKQLLQEKAAFRELIAQLELDPKCKGLPFSSFLILPFQRITRLKLLVQNILKRVEERSEREGTALDAHKELEMVVKACNEGVRKMSRTEQMISIQKKMEFKIKSVPIISHSRWLLKQGELQQMSGPKTSRTLRTKKLF----REIYLFLFNDLLVICRQ--IP------GDKYQVFDSAPRGLLRVEELEDQGQTLANVFILRLLENADDREATYMLKASSQSEMKRWMTSLAPNR-RTKFVSFTSRLLDCPQVQCVHPYVAQQPDELTLELADILNILEKTED 557
BLAST of Rho guanine nucleotide exchange factor vs. Ensembl Mouse
Match: Arhgef16 (Rho guanine nucleotide exchange factor (GEF) 16 [Source:MGI Symbol;Acc:MGI:2446219]) HSP 1 Score: 149.058 bits (375), Expect = 1.939e-36 Identity = 130/482 (26.97%), Postives = 221/482 (45.85%), Query Frame = 1
Query: 907 TRDEDNDSIELEPNIDNDSFADNRVFQLFSATSQRLRWAETEEGKKLINMQKLSEDIIKWQEAQFEVITSEASYYRSLEVLVNKIYKSSWMDCAKEKKNMQDNLSPELDDPPNPFTKPIITATQKHHLFSNILEIHIVSGELLKALESRWRENPLIKDLSDILVDFCSEKLKPYVTYLRNQRFQTDTYNKLLNY-PEFLNIIKKFENDPDCSMMNLCSFLMLPMQRVLRLKLLMTVVKHHIPKGYPT--DGCDEAIEALEKLIKECSDEKMVMEQKEEILLICNRLIIKDKMNVSI--GSKPLLKNGALKVISNNKHASKLLGSSLLNRNNKRAQ--LYLFEDQLIIAKQRKLPLCVSSDDNREVVVDTCQRFNVKFVEISPQKPL-----SR-----FNFKLVLSNGMKGSAEYI-CSVDNPDDLNEWKNAFSVNKSRHEEF----DFGEAFVICDYTPTSKKEIGLKKGQILNIIKRIDN 2286
T E +D I EP+ + + + S +L W++ E + + LS + K QEA FE++TSE SY SL +LV + +S + + +T T+ HHLFSNIL++ S + +ALE R + ++D+SDIL D PY+ Y N+ +Q T KL N F +++K+ E P C + + SFL+LPMQRV RL LL + +G+P +A++A+ KL+K+C++ ME+ E+I + +L ++ + S+ LLK G L ++ SS+ + R L+LF D L++ K++ + +V D Q +V+ ++ P +PL SR + F++ L + +G E I S D+ D W A + + + + + + V Y EI L++ I+ +++ D
Sbjct: 230 TSHESDDDILDEPSGPVGTQRADTTIVVKSYRPAQLTWSQLPEVLESGVLDTLSTEERKRQEAIFEILTSEFSYLHSLSILVTEFLQSREL-------------------------RATMTQTEHHHLFSNILDVMSASQKFFEALEQRHKAQVCVEDISDILEDHAQHHFHPYIAYCSNEVYQQRTLQKLSNSNAAFRDVLKEIEKRPACGGLPMISFLILPMQRVTRLPLLTDTLCLKT-QGHPERYKAASQALKAISKLVKQCNEGAHKMERTEQIYTLNMQLDFGKVKSLPLISASRWLLKRGELFLLEE---------SSIFRKIASRPTCYLFLFNDVLVVTKKK--------SEESYLVQDYAQLDHVQVRKLEPSEPLLPGGSSRSSSVPYPFQVNLLHNSEGRQEQILLSSDSASDRARWITALTYKERQWQGITNKGELPQVEVTKAYFAKQADEITLQQADIVLVLQEEDG 668
BLAST of Rho guanine nucleotide exchange factor vs. Ensembl Mouse
Match: Arhgef16 (Rho guanine nucleotide exchange factor (GEF) 16 [Source:MGI Symbol;Acc:MGI:2446219]) HSP 1 Score: 149.058 bits (375), Expect = 1.939e-36 Identity = 130/482 (26.97%), Postives = 221/482 (45.85%), Query Frame = 1
Query: 907 TRDEDNDSIELEPNIDNDSFADNRVFQLFSATSQRLRWAETEEGKKLINMQKLSEDIIKWQEAQFEVITSEASYYRSLEVLVNKIYKSSWMDCAKEKKNMQDNLSPELDDPPNPFTKPIITATQKHHLFSNILEIHIVSGELLKALESRWRENPLIKDLSDILVDFCSEKLKPYVTYLRNQRFQTDTYNKLLNY-PEFLNIIKKFENDPDCSMMNLCSFLMLPMQRVLRLKLLMTVVKHHIPKGYPT--DGCDEAIEALEKLIKECSDEKMVMEQKEEILLICNRLIIKDKMNVSI--GSKPLLKNGALKVISNNKHASKLLGSSLLNRNNKRAQ--LYLFEDQLIIAKQRKLPLCVSSDDNREVVVDTCQRFNVKFVEISPQKPL-----SR-----FNFKLVLSNGMKGSAEYI-CSVDNPDDLNEWKNAFSVNKSRHEEF----DFGEAFVICDYTPTSKKEIGLKKGQILNIIKRIDN 2286
T E +D I EP+ + + + S +L W++ E + + LS + K QEA FE++TSE SY SL +LV + +S + + +T T+ HHLFSNIL++ S + +ALE R + ++D+SDIL D PY+ Y N+ +Q T KL N F +++K+ E P C + + SFL+LPMQRV RL LL + +G+P +A++A+ KL+K+C++ ME+ E+I + +L ++ + S+ LLK G L ++ SS+ + R L+LF D L++ K++ + +V D Q +V+ ++ P +PL SR + F++ L + +G E I S D+ D W A + + + + + + V Y EI L++ I+ +++ D
Sbjct: 230 TSHESDDDILDEPSGPVGTQRADTTIVVKSYRPAQLTWSQLPEVLESGVLDTLSTEERKRQEAIFEILTSEFSYLHSLSILVTEFLQSREL-------------------------RATMTQTEHHHLFSNILDVMSASQKFFEALEQRHKAQVCVEDISDILEDHAQHHFHPYIAYCSNEVYQQRTLQKLSNSNAAFRDVLKEIEKRPACGGLPMISFLILPMQRVTRLPLLTDTLCLKT-QGHPERYKAASQALKAISKLVKQCNEGAHKMERTEQIYTLNMQLDFGKVKSLPLISASRWLLKRGELFLLEE---------SSIFRKIASRPTCYLFLFNDVLVVTKKK--------SEESYLVQDYAQLDHVQVRKLEPSEPLLPGGSSRSSSVPYPFQVNLLHNSEGRQEQILLSSDSASDRARWITALTYKERQWQGITNKGELPQVEVTKAYFAKQADEITLQQADIVLVLQEEDG 668
BLAST of Rho guanine nucleotide exchange factor vs. Ensembl Mouse
Match: Arhgef26 (Rho guanine nucleotide exchange factor (GEF) 26 [Source:MGI Symbol;Acc:MGI:1918053]) HSP 1 Score: 148.288 bits (373), Expect = 6.121e-36 Identity = 131/473 (27.70%), Postives = 217/473 (45.88%), Query Frame = 1
Query: 1009 RLRWAETEEGKKLINMQKLSEDIIKWQEAQFEVITSEASYYRSLEVLVNKIYKSSWMDCAKEKKNMQDNLSPELDDPPNPFTKPIITATQKHHLFSNILEIHIVSGELLKALESRWRENPLIKDLSDILVDFCSEKLKPYVTYLRNQRFQTDTYNKLLNY-PEFLNIIKKFENDPDCSMMNLCSFLMLPMQRVLRLKLLMTVVKHHIPKGYPT-DGCDEAIEALEKLIKECSDEKMVMEQKEEILLICNRLIIKDK-MNVSIGSKPLLKNGALKVISNNKHASKLLGSSLLNRNNKRAQLY--LFEDQLIIAKQR------------KLPLCVSSDDNREVVVDTCQRFNVKFVEISPQKPLSRFNFKLVLSNGMKGSAEYICSVDNPDDLNEWKNAF--SVNKSRHEEFDFGEAFVICDYTPTSKKEIGLKKGQILNIIKRI-----DNERAIASFSGKQGEILLSCVQYVS 2355
R W++ K+ Q +S++ K QEA FEVI+SE SY SLE+L+ +++K+S K + D + T T++HHLFSNI ++ S + LE+R + N I+D+SDI+ + PYV Y N+ +Q T KLL P F ++ + E+ DC + + SFL+LPMQRV RL LLM + PK P + C A++ + KL++ C++ ME+ E + I ++L K K + S+ L+K G L + + L ++ + Q+Y LF D LII K++ + L V S DN E +++ N + S Q + VLSN + + + + W A S K + + +I +T E+ L+ ++ I +R+ + ER G++G + C + ++
Sbjct: 413 RSTWSQLSAVKRNGLSQTVSQEERKRQEAIFEVISSEHSYLLSLEILI-RMFKNS--------KELTDTM----------------TKTERHHLFSNITDVWEASKKFFTELEARHQNNIFIEDISDIVEKHTASTFDPYVKYCTNEVYQQRTLQKLLATNPSFKEVLSRIESHEDCRNLPMISFLILPMQRVTRLPLLMDTICQKTPKDSPKYEVCKRALKEVSKLVRLCNEGARKMERTEMMYTINSQLEFKIKPFPLVSSSRWLVKRGELTAYVED--------TVLFSKRMSKQQVYFFLFNDVLIITKKKSEESYNVNDYSLRDQLLVESCDNEE--LNSSPGKNPSTMLYSRQSSATHLFTLTVLSNHASEKVDMLLGAETQSERARWITALGHSSGKQPPDRTTLTQVEIIRSFTAKQPDELSLQVADVVLIYQRVGDGWYEGERL---RDGERGWFPMECAKEIT 847
BLAST of Rho guanine nucleotide exchange factor vs. UniProt/SwissProt
Match: sp|Q5BKC9|NGEF_RAT (Ephexin-1 OS=Rattus norvegicus OX=10116 GN=Ngef PE=1 SV=2) HSP 1 Score: 153.68 bits (387), Expect = 3.410e-37 Identity = 121/413 (29.30%), Postives = 202/413 (48.91%), Query Frame = 1
Query: 1081 KWQEAQFEVITSEASYYRSLEVLVNKIYKSSWMDCAKEKKNMQDNLSPELDDPPNPFTKPIITATQKHHLFSNILEIHIVSGELLKALESRWRENPLIKDLSDILVDFCSEKLKPYVTYLRNQRFQTDTYNKLLN-YPEFLNIIKKFENDPDCSMMNLCSFLMLPMQRVLRLKLLMTVVKHHIPKGYPTDGCD-EAIEALEKLIKECSDEKMVMEQKEEILLICNRLIIKDK-MNVSIGSKPLLKNGALKVISNNKHASKLLGSSLLNRNNKRAQLYLFEDQLIIAKQRKLPLCVSSDDNREVVVDTCQRFNVKFVEISPQ-KPLSRFNFKLVLSNGMKGSAEYICSVDNPDDLNEWKNAFSVNKSRHEEFDFGEAFVIC-------DYTPTSKKEIGLKKGQILNIIKRIDN 2286
K QEA FE++TSEASYY+SL +LV S +M+ + KK I+ ++ H LFSN+L++ VS L LE R EN +I D+ DI+ + ++ Y+TY+ NQ +Q TY +LL F +I + E DP C + L SFL+LP QR+ RLKLL+ + + +G +G +A + LE ++K C++ M + E+++ I ++ K K + + S+ LLK G L+ +S K + L L + L+LF D L+I +Q +P ++ V D+ R ++ E+ Q + L+ +L N A Y+ + ++ W + + N+ R + F + C Y E+ L+ ILNI+++ ++
Sbjct: 264 KLQEAMFELVTSEASYYKSLNLLV-----SHFMENERLKK--------------------ILHPSEAHILFSNVLDVMAVSERFLLELEHRMEENIVISDVCDIVYRYAADHFSVYITYVSNQTYQERTYKQLLQEKTAFRELIAQLELDPKCKGLPLSSFLILPFQRITRLKLLVQNILKRVEEGSEREGTALDAHKELEMVVKACNEGVRKMSRTEQMISIQKKMEFKIKSVPIISHSRWLLKQGELQQMSGPKTSRTLRTKKLF----REIYLFLFNDLLVICRQ--IP------GDKYQVFDSAPRGLLRVEELEDQGQTLANVFILRLLENADDREATYMLKASSQSEMKRWMTSLAPNR-RTKFVSFTSRLLDCPQVQCVHPYVAQQPDELTLELADILNILEKTED 638
BLAST of Rho guanine nucleotide exchange factor vs. UniProt/SwissProt
Match: sp|Q8CHT1|NGEF_MOUSE (Ephexin-1 OS=Mus musculus OX=10090 GN=Ngef PE=1 SV=1) HSP 1 Score: 150.599 bits (379), Expect = 3.492e-36 Identity = 119/414 (28.74%), Postives = 201/414 (48.55%), Query Frame = 1
Query: 1078 IKWQEAQFEVITSEASYYRSLEVLVNKIYKSSWMDCAKEKKNMQDNLSPELDDPPNPFTKPIITATQKHHLFSNILEIHIVSGELLKALESRWRENPLIKDLSDILVDFCSEKLKPYVTYLRNQRFQTDTYNKLLN-YPEFLNIIKKFENDPDCSMMNLCSFLMLPMQRVLRLKLLMTVVKHHIPKGYPTDGCD-EAIEALEKLIKECSDEKMVMEQKEEILLICNRLIIKDK-MNVSIGSKPLLKNGALKVISNNKHASKLLGSSLLNRNNKRAQLYLFEDQLIIAKQRKLPLCVSSDDNREVVVDTCQRFNVKFVEISPQ-KPLSRFNFKLVLSNGMKGSAEYICSVDNPDDLNEWKNAFSVNKSRHEEFDFGEAFVIC-------DYTPTSKKEIGLKKGQILNIIKRIDN 2286
I+ QEA FE++TSEASYY+SL +LV S +M+ + KK I+ ++ H LFSN+L++ VS L LE R EN +I D+ DI+ + ++ Y+TY+ NQ +Q TY +LL F +I + E DP C + SFL+LP QR+ RLKLL+ + + + +G +A + LE ++K C++ M + E+++ I ++ K K + + S+ LLK G L+ +S K + L L + L+LF D L+I +Q +P ++ V D+ R ++ E+ Q + L+ +L N A Y+ + ++ W + + N+ R + F + C Y E+ L+ ILNI+++ ++
Sbjct: 272 IRLQEAMFELVTSEASYYKSLNLLV-----SHFMENERLKK--------------------ILHPSEAHILFSNVLDVMAVSERFLLELEHRMEENIVISDVCDIVYRYAADHFSVYITYVSNQTYQERTYKQLLQEKAAFRELIAQLELDPKCKGLPFSSFLILPFQRITRLKLLVQNILKRVEERSEREGTALDAHKELEMVVKACNEGVRKMSRTEQMISIQKKMEFKIKSVPIISHSRWLLKQGELQQMSGPKTSRTLRTKKLF----REIYLFLFNDLLVICRQ--IP------GDKYQVFDSAPRGLLRVEELEDQGQTLANVFILRLLENADDREATYMLKASSQSEMKRWMTSLAPNR-RTKFVSFTSRLLDCPQVQCVHPYVAQQPDELTLELADILNILEKTED 647
BLAST of Rho guanine nucleotide exchange factor vs. UniProt/SwissProt
Match: sp|Q96DR7|ARHGQ_HUMAN (Rho guanine nucleotide exchange factor 26 OS=Homo sapiens OX=9606 GN=ARHGEF26 PE=1 SV=4) HSP 1 Score: 151.369 bits (381), Expect = 5.161e-36 Identity = 133/473 (28.12%), Postives = 216/473 (45.67%), Query Frame = 1
Query: 1009 RLRWAETEEGKKLINMQKLSEDIIKWQEAQFEVITSEASYYRSLEVLVNKIYKSSWMDCAKEKKNMQDNLSPELDDPPNPFTKPIITATQKHHLFSNILEIHIVSGELLKALESRWRENPLIKDLSDILVDFCSEKLKPYVTYLRNQRFQTDTYNKLL-NYPEFLNIIKKFENDPDCSMMNLCSFLMLPMQRVLRLKLLMTVVKHHIPKGYPT-DGCDEAIEALEKLIKECSDEKMVMEQKEEILLICNRLIIKDK-MNVSIGSKPLLKNGALKVISNNKHASKLLGSSLLNRNNKRAQLY--LFEDQLIIAKQR------------KLPLCVSSDDNREVVVDTCQRFNVKFVEISPQKPLSRFNFKLVLSNGMKGSAEYICSVDNPDDLNEWKNAF--SVNKSRHEEFDFGEAFVICDYTPTSKKEIGLKKGQILNIIKRI-----DNERAIASFSGKQGEILLSCVQYVS 2355
R W++ K+ Q +S++ K QEA FEVI+SE SY SLE+L+ +++K+S K + D + T T++HHLFSNI ++ S + LE+R + N I D+SDI+ + PYV Y N+ +Q T KLL P F ++ + E+ DC + + SFL+LPMQRV RL LLM + PK P + C A++ + KL++ C++ ME+ E + I ++L K K + S+ L+K G L + + L +R + Q+Y LF D LII K++ + L V S DN E +++ N + S Q S VLSN E + + + W A S K + + ++ +T E+ L+ ++ I +R+ + ER G++G + C + ++
Sbjct: 415 RSTWSQLSAVKRKGLSQTVSQEERKRQEAIFEVISSEHSYLLSLEILI-RMFKNS--------KELSDTM----------------TKTERHHLFSNITDVCEASKKFFIELEARHQNNIFIDDISDIVEKHTASTFDPYVKYCTNEVYQQRTLQKLLATNPSFKEVLSRIESHEDCRNLPMISFLILPMQRVTRLPLLMDTICQKTPKDSPKYEVCKRALKEVSKLVRLCNEGARKMERTEMMYTINSQLEFKIKPFPLVSSSRWLVKRGELTAYVED--------TVLFSRRTSKQQVYFFLFNDVLIITKKKSEESYNVNDYSLRDQLLVESCDNEE--LNSSPGKNSSTMLYSRQSSASHLFTLTVLSNHANEKVEMLLGAETQSERARWITALGHSSGKPPADRTSLTQVEIVRSFTAKQPDELSLQVADVVLIYQRVSDGWYEGERL---RDGERGWFPMECAKEIT 849
BLAST of Rho guanine nucleotide exchange factor vs. UniProt/SwissProt
Match: sp|Q3U5C8|ARHGG_MOUSE (Rho guanine nucleotide exchange factor 16 OS=Mus musculus OX=10090 GN=Arhgef16 PE=1 SV=3) HSP 1 Score: 149.058 bits (375), Expect = 1.357e-35 Identity = 130/482 (26.97%), Postives = 221/482 (45.85%), Query Frame = 1
Query: 907 TRDEDNDSIELEPNIDNDSFADNRVFQLFSATSQRLRWAETEEGKKLINMQKLSEDIIKWQEAQFEVITSEASYYRSLEVLVNKIYKSSWMDCAKEKKNMQDNLSPELDDPPNPFTKPIITATQKHHLFSNILEIHIVSGELLKALESRWRENPLIKDLSDILVDFCSEKLKPYVTYLRNQRFQTDTYNKLLNY-PEFLNIIKKFENDPDCSMMNLCSFLMLPMQRVLRLKLLMTVVKHHIPKGYPT--DGCDEAIEALEKLIKECSDEKMVMEQKEEILLICNRLIIKDKMNVSI--GSKPLLKNGALKVISNNKHASKLLGSSLLNRNNKRAQ--LYLFEDQLIIAKQRKLPLCVSSDDNREVVVDTCQRFNVKFVEISPQKPL-----SR-----FNFKLVLSNGMKGSAEYI-CSVDNPDDLNEWKNAFSVNKSRHEEF----DFGEAFVICDYTPTSKKEIGLKKGQILNIIKRIDN 2286
T E +D I EP+ + + + S +L W++ E + + LS + K QEA FE++TSE SY SL +LV + +S + + +T T+ HHLFSNIL++ S + +ALE R + ++D+SDIL D PY+ Y N+ +Q T KL N F +++K+ E P C + + SFL+LPMQRV RL LL + +G+P +A++A+ KL+K+C++ ME+ E+I + +L ++ + S+ LLK G L ++ SS+ + R L+LF D L++ K++ + +V D Q +V+ ++ P +PL SR + F++ L + +G E I S D+ D W A + + + + + + V Y EI L++ I+ +++ D
Sbjct: 230 TSHESDDDILDEPSGPVGTQRADTTIVVKSYRPAQLTWSQLPEVLESGVLDTLSTEERKRQEAIFEILTSEFSYLHSLSILVTEFLQSREL-------------------------RATMTQTEHHHLFSNILDVMSASQKFFEALEQRHKAQVCVEDISDILEDHAQHHFHPYIAYCSNEVYQQRTLQKLSNSNAAFRDVLKEIEKRPACGGLPMISFLILPMQRVTRLPLLTDTLCLKT-QGHPERYKAASQALKAISKLVKQCNEGAHKMERTEQIYTLNMQLDFGKVKSLPLISASRWLLKRGELFLLEE---------SSIFRKIASRPTCYLFLFNDVLVVTKKK--------SEESYLVQDYAQLDHVQVRKLEPSEPLLPGGSSRSSSVPYPFQVNLLHNSEGRQEQILLSSDSASDRARWITALTYKERQWQGITNKGELPQVEVTKAYFAKQADEITLQQADIVLVLQEEDG 668
BLAST of Rho guanine nucleotide exchange factor vs. UniProt/SwissProt
Match: sp|Q5RDX5|NGEF_PONAB (Ephexin-1 OS=Pongo abelii OX=9601 GN=NGEF PE=2 SV=1) HSP 1 Score: 148.288 bits (373), Expect = 2.175e-35 Identity = 123/434 (28.34%), Postives = 206/434 (47.47%), Query Frame = 1
Query: 1018 WAETEEGKKLINMQKLSEDIIKWQEAQFEVITSEASYYRSLEVLVNKIYKSSWMDCAKEKKNMQDNLSPELDDPPNPFTKPIITATQKHHLFSNILEIHIVSGELLKALESRWRENPLIKDLSDILVDFCSEKLKPYVTYLRNQRFQTDTYNKLLN-YPEFLNIIKKFENDPDCSMMNLCSFLMLPMQRVLRLKLLM-TVVKHHIPKGYPTDGCDEAIEALEKLIKECSDEKMVMEQKEEILLICNRLIIKDK-MNVSIGSKPLLKNGALKVISNNKHASKLLGSSLLNRNNKRAQLYLFEDQLIIAKQRKLPLCVSSDDNREVVVDTCQRFNVKFVEISPQ-KPLSRFNFKLVLSNGMKGSAEYICSVDNPDDLNEWKNAFSVNKSRHEEFDFGEAFVIC-------DYTPTSKKEIGLKKGQILNIIKRIDN 2286
W + E + ++ L + IK QEA FE++TSEASYY+SL +LV S +M+ N + I+ ++ H LFSN+L++ VS L LE R EN +I D+ DI+ + ++ Y+TY+ NQ +Q TY +LL F +I + E DP C + SFL+LP QR+ RLKLL+ ++K + +A + LE ++K C++ M + E+++ I ++ K K + + S+ LLK G L+ +S K + L L + L+LF D L+I +Q +P ++ V D+ R ++ E+ Q + L+ +L N A Y+ + ++ W + + N+ R + F + C Y E+ L+ ILNI+ + D+
Sbjct: 251 WQDLPEIRSSGVLEILQPEEIKLQEAMFELVTSEASYYKSLNLLV-----SHFME--------------------NERIRKILHPSEAHILFSNVLDVLAVSERFLLELEHRMEENIVISDVCDIVYRYAADHFSVYITYVSNQTYQERTYKQLLQEKAAFRELIAQLELDPKCRGLPFSSFLILPFQRITRLKLLVQNILKRVEERSERECTALDAHKELEMVVKACNEGVRKMSRTEQMISIQKKMEFKIKSVPIISHSRWLLKQGELQQMSGPKTSRTLRTKKLFH----EIYLFLFNDLLVICRQ--IP------GDKYQVFDSAPRGLLRVEELEDQGQTLANVFILRLLENADDREATYMLKASSQSEMKRWMTSLAPNR-RTKFVSFTSRLLDCPQVQCVHPYVAQQPDELTLELADILNILDKTDD 646
BLAST of Rho guanine nucleotide exchange factor vs. TrEMBL
Match: A0A068WNV2 (Rho guanine nucleotide exchange factor 16 OS=Echinococcus granulosus OX=6210 GN=EgrG_000237400 PE=4 SV=1) HSP 1 Score: 209.149 bits (531), Expect = 2.469e-52 Identity = 153/484 (31.61%), Postives = 246/484 (50.83%), Query Frame = 1
Query: 586 KQSIGKTFIPTSD---ADKENEGVLIRMRNQESYYDGKDKYQSQLPEAPLYQVY-----------------ENIRQ-RRSNFAQKAHEKP---IDPTDYELNNDAIQNSIIFPRTSL--PSVDENCKFQERTTTRDEDNDSIELEPNIDNDSFADNRVFQLFSATS-QRLRWAETEEGKKLINMQKLSEDIIKWQEAQFEVITSEASYYRSLEVLVNKIYKSSWMDCAKEKKNMQDNLSPELDDPPNPFTK-PIITATQKHHLFSNILEIHIVSGELLKALESRWRENPLIKDLSDILVDFCSEKLKPYVTYLRNQRFQTDTYNKLLNYPEFLNIIKKFENDPDCSMMNLCSFLMLPMQRVLRLKLLMTVVKHHIPKGYPT-DGCDEAIEALEKLIKECSDEKMVMEQKEEILLICNRLIIKDKMN-VSIGSKPLLKNGALKVISNN---KHASKLLGSSLLNRNNKRAQLYLFEDQLIIAKQR 1938
K K+ + D + + + V++R+ + E YD + ++S APLYQ+Y E+IR RR Q+ +P + P + ++ + +S L PS + F RD ++E N V FS T R+RW++ E +L L+++ QEA+FE+ITSEASYY+SL VL++ YK+ NP +IT KH LFSNIL IH+ S LL +LE+ +R++P++ ++ DIL + KL YVTY++NQ +QT T +KL+N P F ++ ++ P CS ++L SFL+LPMQRV+RL+LL+ V H+ P+ + A+ +LEKLI EC+ +K MEQKE ++ + ++L K + V GS+ L+K G L+++ ++ A + S + + L+LF D L++AK++
Sbjct: 119 KSFFAKSLVAEEDELQGNGDRKKVILRLEDAEKKYDNRLSFKSIFGNAPLYQIYDEHFKRKEIRRLHHRLRESIRSLRRKRGDQRPLRQPKAIVSPPKFGPDDQSSSSSSSGDEDELKTPSSAKASSFT--VIKRDLSRRRSDVERTAKMGEM--NSVANEFSGTGPSRVRWSDMLEVVRLNLAAGLTKEQRSLQEARFEIITSEASYYKSLTVLIDLFYKAPVF---------------------NPIAANAVITEFDKHQLFSNILNIHVTSENLLHSLETSFRKDPMMGNICDILYEHSETKLSYYVTYVKNQMYQTRTLSKLMNRPSFKEAVQNIQSMPQCSGLDLNSFLVLPMQRVMRLRLLVAAVIHYTPRSLSAYESGLVALASLEKLIAECNSQKGHMEQKERLVTLSSQLEFKSNLRAVGTGSRELVKEGNLRLLESSNLPNAAFRRKFSETIKNKPIQITLFLFTDILLVAKRK 577
BLAST of Rho guanine nucleotide exchange factor vs. TrEMBL
Match: W6V9R2 (Rho guanine nucleotide exchange factor OS=Echinococcus granulosus OX=6210 GN=EGR_01895 PE=4 SV=1) HSP 1 Score: 208.379 bits (529), Expect = 3.318e-51 Identity = 153/484 (31.61%), Postives = 246/484 (50.83%), Query Frame = 1
Query: 586 KQSIGKTFIPTSD---ADKENEGVLIRMRNQESYYDGKDKYQSQLPEAPLYQVY-----------------ENIRQ-RRSNFAQKAHEKP---IDPTDYELNNDAIQNSIIFPRTSL--PSVDENCKFQERTTTRDEDNDSIELEPNIDNDSFADNRVFQLFSATS-QRLRWAETEEGKKLINMQKLSEDIIKWQEAQFEVITSEASYYRSLEVLVNKIYKSSWMDCAKEKKNMQDNLSPELDDPPNPFTK-PIITATQKHHLFSNILEIHIVSGELLKALESRWRENPLIKDLSDILVDFCSEKLKPYVTYLRNQRFQTDTYNKLLNYPEFLNIIKKFENDPDCSMMNLCSFLMLPMQRVLRLKLLMTVVKHHIPKGYPT-DGCDEAIEALEKLIKECSDEKMVMEQKEEILLICNRLIIKDKMN-VSIGSKPLLKNGALKVISNN---KHASKLLGSSLLNRNNKRAQLYLFEDQLIIAKQR 1938
K K+ + D + + + V++R+ + E YD + ++S APLYQ+Y E+IR RR Q+ +P + P + ++ + +S L PS + F RD ++E N V FS T R+RW++ E +L L+++ QEA+FE+ITSEASYY+SL VL++ YK+ NP +IT KH LFSNIL IH+ S LL +LE+ +R++P++ ++ DIL + KL YVTY++NQ +QT T +KL+N P F ++ ++ P CS ++L SFL+LPMQRV+RL+LL+ V H+ P+ + A+ +LEKLI EC+ +K MEQKE ++ + ++L K + V GS+ L+K G L+++ ++ A + S + + L+LF D L++AK++
Sbjct: 629 KSFFAKSLVAEEDELQGNGDRKKVILRLEDAEKKYDNRLSFKSIFGNAPLYQIYDEHFKRKEIRRLHHRLRESIRSLRRKRGDQRPLRQPKAIVSPPKFGPDDQSSSSSSSGDEDELKTPSSAKASSFT--VIKRDLSRRRSDVERTAKMGEM--NSVANEFSGTGPSRVRWSDMLEVVRLNLAAGLTKEQRSLQEARFEIITSEASYYKSLTVLIDLFYKAPVF---------------------NPIAANAVITEFDKHQLFSNILNIHVTSENLLHSLETSFRKDPMMGNICDILYEHSETKLSYYVTYVKNQMYQTRTLSKLMNRPSFKEAVQNIQSMPQCSGLDLNSFLVLPMQRVMRLRLLVAAVIHYTPRSLSAYESGLVALASLEKLIAECNSQKGHMEQKERLVTLSSQLEFKSNLRAVGTGSRELVKEGNLRLLESSNLPNAAFRRKFSETIKNKPIQITLFLFTDILLVAKRK 1087
BLAST of Rho guanine nucleotide exchange factor vs. TrEMBL
Match: A0A564Z8G4 (Uncharacterized protein OS=Hymenolepis diminuta OX=6216 GN=WMSIL1_LOCUS13013 PE=4 SV=1) HSP 1 Score: 205.297 bits (521), Expect = 4.324e-51 Identity = 144/455 (31.65%), Postives = 242/455 (53.19%), Query Frame = 1
Query: 646 VLIRMRNQESYYDGKDKYQSQLPEAPLYQVYENIRQR--------------RSNFAQKAHEKPIDPTDYELNNDAIQNSIIFPRTSLPSVDENCKFQERTTTRDEDNDSIELEPNIDNDSFAD--NRVFQLFSATS-QRLRWAETEEGKKLINMQKLSEDIIKWQEAQFEVITSEASYYRSLEVLVNKIYKSSWMDCAKEKKNMQDNLSPELDDPPNPFTKPIITATQKHHLFSNILEIHIVSGELLKALESRWRENPLIKDLSDILVDFCSEKLKPYVTYLRNQRFQTDTYNKLLNYPEFLNIIKKFENDPDCSMMNLCSFLMLPMQRVLRLKLLMTVVKHHIPK---GYPTDGCDEAIEALEKLIKECSDEKMVMEQKEEILLICNRLIIKDKMN-VSIGSKPLLKNGALKVI--SNNKHAS-KLLGSSLLNRNNKRAQLYLFEDQLIIAKQR 1938
+ +R+ + E Y+ + + + APLYQ+Y+ +R RS +K ++P+ + ++ S DEN + + D + + +++ + N V + FS + R+RW + E + + L+++ QEA+FE+ITSEASYY+SL VL++ YK+ + + PN +IT KH LFSNIL IH+ S LL +LE+ +R++P+++++ DIL + KL YVTY++NQ +QT T +KLLN P F +++ ++ P C ++L SFL+LPMQRV+RL+LL+ V H+ P+ Y + C A+ +LEKLI EC+ +K MEQKE ++ + ++L K + V GS+ L+K G L+++ SN +A+ + S + + L+LF D L+IAK++
Sbjct: 133 ISMRLADAEKKYETRGSFATIFGNAPLYQIYDEYSKRKESQRFRHRLRESIRSLRKKKGEQRPLKEPKAIVAPPKFGPDDQSSTSTSSSDDENAGLPKSSNFTVIKKDVVRKKSDVERTAKMGEMNNVAKEFSGSGPARVRWTDMPEVIRRNLAEGLTKEQRSLQEARFEIITSEASYYKSLTVLIDLFYKAPVFNPSA----------------PNS----VITEFDKHQLFSNILNIHVTSENLLHSLETCFRQDPMMENICDILYEHSESKLSFYVTYVKNQMYQTRTLSKLLNRPAFKEAVQQIQSMPQCMGLDLNSFLVLPMQRVMRLRLLVAAVIHYTPRSSLAYESGLC--ALASLEKLISECNMQKGHMEQKERLVTLSSQLEFKSNIRAVGTGSRELIKEGNLRLLETSNLPNAAFRRKFSEAIKNKPVQITLFLFSDILLIAKRK 565
BLAST of Rho guanine nucleotide exchange factor vs. TrEMBL
Match: A0A087W205 (Rho guanine nucleotide exchange factor 16 OS=Echinococcus multilocularis OX=6211 GN=EmuJ_000237400 PE=4 SV=1) HSP 1 Score: 205.297 bits (521), Expect = 5.347e-51 Identity = 141/459 (30.72%), Postives = 234/459 (50.98%), Query Frame = 1
Query: 646 VLIRMRNQESYYDGKDKYQSQLPEAPLYQVYENIRQRRSNFAQKAHEKPIDPTDYELNNDAIQNSIIFPRTSLPSVDENCKFQERTTTRDEDNDSIELEPNIDNDSFAD---------------------NRVFQLFSATS-QRLRWAETEEGKKLINMQKLSEDIIKWQEAQFEVITSEASYYRSLEVLVNKIYKSSWMDCAKEKKNMQDNLSPELDDPPNPFTK-PIITATQKHHLFSNILEIHIVSGELLKALESRWRENPLIKDLSDILVDFCSEKLKPYVTYLRNQRFQTDTYNKLLNYPEFLNIIKKFENDPDCSMMNLCSFLMLPMQRVLRLKLLMTVVKHHIPKGYPT-DGCDEAIEALEKLIKECSDEKMVMEQKEEILLICNRLIIKDKMN-VSIGSKPLLKNGALKVISNN---KHASKLLGSSLLNRNNKRAQLYLFEDQLIIAKQR 1938
V++R+ + E YD + ++S APLYQ+Y+ +R+ ++ H + + Q + P+ + Q +++ D D ++ + SF N V FS R+RW++ E +L L+++ QEA+FE+ITSEASYY+SL VL++ YK+ NP +IT KH LFSNIL IH+ S LL +LE+ +R++P++ ++ DIL + KL YVTY++NQ +QT T ++L+N P F ++ ++ P CS ++L SFL+LPMQRV+RL+LL+ V H+ P+ P + A+ +LEKLI EC+ +K MEQKE ++ + ++L K + V S+ L+K G L+++ ++ A + S + + L+LF D L++AK++
Sbjct: 142 VIMRLEDAEKRYDNRLSFKSIFGNAPLYQIYDEHFKRKE--IRRLHHRLRESIRSLRRKKGDQRPLRQPKAIVSPPKFGPDDQSSSSSSSGDEDELKTPSSAKASSFTVIKRNLSRRRSDVERTAKMGEMNSVANEFSGIGPSRVRWSDMLEVVRLNLAAGLTKEQHSLQEARFEIITSEASYYKSLTVLIDLFYKAPVF---------------------NPIAANAVITEFDKHQLFSNILNIHVTSENLLHSLETSFRKDPMMGNICDILYEHSETKLSYYVTYVKNQMYQTRTLSRLMNRPSFKEAVQNIQSMPQCSGLDLNSFLVLPMQRVMRLRLLVAAVIHYTPRSLPAYESGLVALASLEKLIAECNSQKGHMEQKERLVTLSSQLEFKSNLRAVGTDSRELVKEGNLRLLESSNLPNAAFRRKFSETIKNKPIQITLFLFTDILLVAKRK 577
BLAST of Rho guanine nucleotide exchange factor vs. TrEMBL
Match: A0A564Z6J6 (Uncharacterized protein OS=Hymenolepis diminuta OX=6216 GN=WMSIL1_LOCUS13013 PE=4 SV=1) HSP 1 Score: 204.912 bits (520), Expect = 5.863e-51 Identity = 144/455 (31.65%), Postives = 242/455 (53.19%), Query Frame = 1
Query: 646 VLIRMRNQESYYDGKDKYQSQLPEAPLYQVYENIRQR--------------RSNFAQKAHEKPIDPTDYELNNDAIQNSIIFPRTSLPSVDENCKFQERTTTRDEDNDSIELEPNIDNDSFAD--NRVFQLFSATS-QRLRWAETEEGKKLINMQKLSEDIIKWQEAQFEVITSEASYYRSLEVLVNKIYKSSWMDCAKEKKNMQDNLSPELDDPPNPFTKPIITATQKHHLFSNILEIHIVSGELLKALESRWRENPLIKDLSDILVDFCSEKLKPYVTYLRNQRFQTDTYNKLLNYPEFLNIIKKFENDPDCSMMNLCSFLMLPMQRVLRLKLLMTVVKHHIPK---GYPTDGCDEAIEALEKLIKECSDEKMVMEQKEEILLICNRLIIKDKMN-VSIGSKPLLKNGALKVI--SNNKHAS-KLLGSSLLNRNNKRAQLYLFEDQLIIAKQR 1938
+ +R+ + E Y+ + + + APLYQ+Y+ +R RS +K ++P+ + ++ S DEN + + D + + +++ + N V + FS + R+RW + E + + L+++ QEA+FE+ITSEASYY+SL VL++ YK+ + + PN +IT KH LFSNIL IH+ S LL +LE+ +R++P+++++ DIL + KL YVTY++NQ +QT T +KLLN P F +++ ++ P C ++L SFL+LPMQRV+RL+LL+ V H+ P+ Y + C A+ +LEKLI EC+ +K MEQKE ++ + ++L K + V GS+ L+K G L+++ SN +A+ + S + + L+LF D L+IAK++
Sbjct: 133 ISMRLADAEKKYETRGSFATIFGNAPLYQIYDEYSKRKESQRFRHRLRESIRSLRKKKGEQRPLKEPKAIVAPPKFGPDDQSSTSTSSSDDENAGLPKSSNFTVIKKDVVRKKSDVERTAKMGEMNNVAKEFSGSGPARVRWTDMPEVIRRNLAEGLTKEQRSLQEARFEIITSEASYYKSLTVLIDLFYKAPVFNPSA----------------PNS----VITEFDKHQLFSNILNIHVTSENLLHSLETCFRQDPMMENICDILYEHSESKLSFYVTYVKNQMYQTRTLSKLLNRPAFKEAVQQIQSMPQCMGLDLNSFLVLPMQRVMRLRLLVAAVIHYTPRSSLAYESGLC--ALASLEKLISECNMQKGHMEQKERLVTLSSQLEFKSNIRAVGTGSRELIKEGNLRLLETSNLPNAAFRRKFSEAIKNKPVQITLFLFSDILLIAKRK 565
BLAST of Rho guanine nucleotide exchange factor vs. Ensembl Cavefish
Match: ARHGEF26 (Rho guanine nucleotide exchange factor 26 [Source:NCBI gene;Acc:103044275]) HSP 1 Score: 160.229 bits (404), Expect = 9.800e-40 Identity = 143/522 (27.39%), Postives = 244/522 (46.74%), Query Frame = 1
Query: 889 FQERTTTRDEDNDSIELEPNIDNDSFADNRVFQLFSATSQRLRWAETEEGKKLINMQKLSEDIIKWQEAQFEVITSEASYYRSLEVLVNKIYKSSWMDCAKEKKNMQDNLSPELDDPPNPFTKPIITATQKHHLFSNILEIHIVSGELLKALESRWRENPLIKDLSDILVDFCSEKLKPYVTYLRNQRFQTDTYNKLLNY-PEFLNIIKKFENDPDCSMMNLCSFLMLPMQRVLRLKLLMTVVKHHIPKGYPT-DGCDEAIEALEKLIKECSDEKMVMEQKEEILLICNRLIIKDK-MNVSIGSKPLLKNGALKVISNNKHASKLLGSSLLNRNNKRAQLY--LFEDQLIIAKQRKLPLCVSSDDNREVV---------VDTCQRFNVKFVEISPQKP--------------LSRFNFKLVLSNGMKGSAEYICSVDNPDDLNEWKNAF--SVNKSRH-EEFDFGEAFVICDYTPTSKKEIGLKKGQILNIIKRIDNE--RAIASFSGKQGEILLSCVQYVS 2355
+QE+ D D D+ E ++ N++ R W++ KK +KLS++ K QEA FEVI+SE SY SL +L+ +++K S EL + +T T HHLFSNI+++ S + K LE R ++N +I D+SDI++ +PYVTY N+ +Q T +LL+ P F ++ + E DC + +CSFL+LPMQRV RL LL+ + PK P + C +A+ + KL+++C++ ME+ E + I ++L K K + S+ ++K G L S K+ S+ ++ R Q+Y LF D LI+ +++ S+++ V+ V +CQ ++ +SP + L R F+ SN K I + ++ W +A S N+ R+ + + + VI YT E+ L+ ++ + + +D+ + G++G L C Q ++
Sbjct: 409 YQEKALHNDSDEDAESREAKPEDRIVVQNKLI--------RTSWSQLSVVKKSEAAKKLSQEERKRQEAIFEVISSEHSYLHSLMILI-RLFKDSQ----------------ELSE--------TMTKTDHHHLFSNIVDVCETSKKFFKELEDRHQQNIVIDDISDIVIRHAQSNFEPYVTYCSNEVYQQRTLQRLLSKNPSFKEVLNRIETHSDCRNLPMCSFLILPMQRVTRLPLLVDTICQKTPKDSPQYEECKKALHCVSKLVRKCNEGARKMERTEMMYTINSQLEFKIKPFPLVSSSRWMVKRGELTAYSEEKN-------SIFSKRMSRQQVYFFLFNDVLIVTRKK-------SEESYTVIDYALRDQIWVGSCQPEDLN---LSPTRTTAGMLTSRQGGASHLFRLKFR---SNHSKEKVLMILGAELLNERARWISALGQSNNEKRNSDRINAMQVEVIRTYTARQPDELSLQVADVVLVSQTVDDGWYEGMRLRDGERGWFLSECAQPIT 877
BLAST of Rho guanine nucleotide exchange factor vs. Ensembl Cavefish
Match: arhgef16 (rho guanine nucleotide exchange factor 16 [Source:NCBI gene;Acc:103040535]) HSP 1 Score: 156.377 bits (394), Expect = 4.400e-39 Identity = 135/463 (29.16%), Postives = 222/463 (47.95%), Query Frame = 1
Query: 1018 WAETEEGKKLINMQKLSEDIIKWQEAQFEVITSEASYYRSLEVLVNKIYKSSWMDCAKEKKNMQDNLSPELDDPPNPFTKPIITATQKHHLFSNILEIHIVSGELLKALESRWRENPLIKDLSDILVDFCSEKLKPYVTYLRNQRFQTDTYNKLL-NYPEFLNIIKKFENDPDCSMMNLCSFLMLPMQRVLRLKLLMTVVKHHIPKGYPT-DGCDEAIEALEKLIKECSDEKMVMEQKEEILLICNRL---IIKDKMNVSIGSKPLLKNGALKVISNNKHASKLLGSSLLNRNNKRAQLYLFEDQLIIAKQRKLPLCVSSDDNREVVVDTCQRFNVKFVEISPQKPLSRFNFKLVLSNGMKGSAEYICSV-DNPDDLNEWKNAFSVNKS-----RHEEFDFGEAFVICDYTPTSKKEIGLKKGQILNIIKRID----NERAIASFSGKQGEILLSCVQYVSTP 2361
W++ +++ ++ +S + K QE FE++TSE SY SL +LV + +K+S D+L + +TAT+ HHLFSNI I VS + LE R + +P+IKD+SDI+ D+ + KPY+ Y N+ FQ T KLL + F ++KK E+ P+C + + SFL+LPMQR RL LLM + PK A++ + KL+K C+D ME+ E++ I ++ IK VS S+ LLK G L + N L + ++K L++F D LI+ K++ + VV D NV+ VE ++ S+ +L + +G E + V +N D W A +K ++E EA Y P E+ +++ +++ +++ ++ ER G++G SC ++ P
Sbjct: 237 WSQLPVVQEMGILETISPEERKRQEVIFEIMTSEYSYLHSLSILV-RHFKAS------------DDL------------RKAMTATEHHHLFSNISVIQAVSKRFFEELERRHQLDPVIKDISDIVQDYAANHFKPYIVYCSNETFQQRTLQKLLASNTAFKEVLKKIESSPECGGLPMISFLILPMQRATRLPLLMDTICQKTPKQTTNYYAARWALKEISKLVKSCNDGARRMERTEQMYTIQKQMEFGRIKPFPLVS-ASRWLLKKGELAI---NLEELGLFWKAF---SHKSYWLFVFNDVLIVTKRK--------SEESYVVCDYATLENVEVVE---EQADSKHYLRLTMKPNSEGRCEQMAFVSENKLDRARWVTALRRHKQAESILSNDELPQYEA--TKAYMPKEPDELSMQQAEVVIVLQEVEGWCYGERM---RDGEKGWFPASCATQITNP 651
BLAST of Rho guanine nucleotide exchange factor vs. Ensembl Cavefish
Match: arhgef16 (rho guanine nucleotide exchange factor 16 [Source:NCBI gene;Acc:103040535]) HSP 1 Score: 156.377 bits (394), Expect = 4.400e-39 Identity = 135/463 (29.16%), Postives = 222/463 (47.95%), Query Frame = 1
Query: 1018 WAETEEGKKLINMQKLSEDIIKWQEAQFEVITSEASYYRSLEVLVNKIYKSSWMDCAKEKKNMQDNLSPELDDPPNPFTKPIITATQKHHLFSNILEIHIVSGELLKALESRWRENPLIKDLSDILVDFCSEKLKPYVTYLRNQRFQTDTYNKLL-NYPEFLNIIKKFENDPDCSMMNLCSFLMLPMQRVLRLKLLMTVVKHHIPKGYPT-DGCDEAIEALEKLIKECSDEKMVMEQKEEILLICNRL---IIKDKMNVSIGSKPLLKNGALKVISNNKHASKLLGSSLLNRNNKRAQLYLFEDQLIIAKQRKLPLCVSSDDNREVVVDTCQRFNVKFVEISPQKPLSRFNFKLVLSNGMKGSAEYICSV-DNPDDLNEWKNAFSVNKS-----RHEEFDFGEAFVICDYTPTSKKEIGLKKGQILNIIKRID----NERAIASFSGKQGEILLSCVQYVSTP 2361
W++ +++ ++ +S + K QE FE++TSE SY SL +LV + +K+S D+L + +TAT+ HHLFSNI I VS + LE R + +P+IKD+SDI+ D+ + KPY+ Y N+ FQ T KLL + F ++KK E+ P+C + + SFL+LPMQR RL LLM + PK A++ + KL+K C+D ME+ E++ I ++ IK VS S+ LLK G L + N L + ++K L++F D LI+ K++ + VV D NV+ VE ++ S+ +L + +G E + V +N D W A +K ++E EA Y P E+ +++ +++ +++ ++ ER G++G SC ++ P
Sbjct: 237 WSQLPVVQEMGILETISPEERKRQEVIFEIMTSEYSYLHSLSILV-RHFKAS------------DDL------------RKAMTATEHHHLFSNISVIQAVSKRFFEELERRHQLDPVIKDISDIVQDYAANHFKPYIVYCSNETFQQRTLQKLLASNTAFKEVLKKIESSPECGGLPMISFLILPMQRATRLPLLMDTICQKTPKQTTNYYAARWALKEISKLVKSCNDGARRMERTEQMYTIQKQMEFGRIKPFPLVS-ASRWLLKKGELAI---NLEELGLFWKAF---SHKSYWLFVFNDVLIVTKRK--------SEESYVVCDYATLENVEVVE---EQADSKHYLRLTMKPNSEGRCEQMAFVSENKLDRARWVTALRRHKQAESILSNDELPQYEA--TKAYMPKEPDELSMQQAEVVIVLQEVEGWCYGERM---RDGEKGWFPASCATQITNP 651
BLAST of Rho guanine nucleotide exchange factor vs. Ensembl Cavefish
Match: ARHGEF26 (Rho guanine nucleotide exchange factor 26 [Source:NCBI gene;Acc:103044275]) HSP 1 Score: 153.68 bits (387), Expect = 1.009e-37 Identity = 139/515 (26.99%), Postives = 238/515 (46.21%), Query Frame = 1
Query: 889 FQERTTTRDEDNDSIELEPNIDNDSFADNRVFQLFSATSQRLRWAETEEGKKLINMQKLSEDIIKWQEAQFEVITSEASYYRSLEVLVNKIYKSSWMDCAKEKKNMQDNLSPELDDPPNPFTKPIITATQKHHLFSNILEIHIVSGELLKALESRWRENPLIKDLSDILVDFCSEKLKPYVTYLRNQRFQTDTYNKLLNY-PEFLNIIKKFENDPDCSMMNLCSFLMLPMQRVLRLKLLMTVVKHHIPKGYPT-DGCDEAIEALEKLIKECSDEKMVMEQKEEILLICNRLIIKDK-MNVSIGSKPLLKNGALKVISNNKHASKLLGSSLLNRNNKRAQLY--LFEDQLIIAKQRKLP--LCVSSDDNREVVVDTCQRFNVKFVEISPQKP--------------LSRFNFKLVLSNGMKGSAEYICSVDNPDDLNEWKNAF--SVNKSRH-EEFDFGEAFVICDYTPTSKKEIGLKKGQILNIIKRIDNE--RAIASFSGKQGEILLSCVQYVS 2355
+QE+ D D D+ E ++ N++ R W++ KLS++ K QEA FEVI+SE SY SL +L+ +++K S EL + +T T HHLFSNI+++ S + K LE R ++N +I D+SDI++ +PYVTY N+ +Q T +LL+ P F ++ + E DC + +CSFL+LPMQRV RL LL+ + PK P + C +A+ + KL+++C++ ME+ E + I ++L K K + S+ ++K G L S K+ S+ ++ R Q+Y LF D LI+ +++ + ++ V +CQ ++ +SP + L R F+ SN K I + ++ W +A S N+ R+ + + + VI YT E+ L+ ++ + + +D+ + G++G L C Q ++
Sbjct: 367 YQEKALHNDSDEDAESREAKPEDRIVVQNKLI--------RTSWSQLS--------VKLSQEERKRQEAIFEVISSEHSYLHSLMILI-RLFKDSQ----------------ELSE--------TMTKTDHHHLFSNIVDVCETSKKFFKELEDRHQQNIVIDDISDIVIRHAQSNFEPYVTYCSNEVYQQRTLQRLLSKNPSFKEVLNRIETHSDCRNLPMCSFLILPMQRVTRLPLLVDTICQKTPKDSPQYEECKKALHCVSKLVRKCNEGARKMERTEMMYTINSQLEFKIKPFPLVSSSRWMVKRGELTAYSEEKN-------SIFSKRMSRQQVYFFLFNDVLIVTRKKSEESYTVIDYALRDQIWVGSCQPEDLN---LSPTRTTAGMLTSRQGGASHLFRLKFR---SNHSKEKVLMILGAELLNERARWISALGQSNNEKRNSDRINAMQVEVIRTYTARQPDELSLQVADVVLVSQTVDDGWYEGMRLRDGERGWFLSECAQPIT 827
BLAST of Rho guanine nucleotide exchange factor vs. Ensembl Cavefish
Match: si:dkey-38p12.3 (rho guanine nucleotide exchange factor 15-like [Source:NCBI gene;Acc:103030780]) HSP 1 Score: 147.517 bits (371), Expect = 1.134e-35 Identity = 126/454 (27.75%), Postives = 211/454 (46.48%), Query Frame = 1
Query: 967 ADNRVFQLFSATSQRLRWAETEEGKKLINMQKLSEDIIKWQEAQFEVITSEASYYRSLEVLVNKIYKSSWMDCAKEKKNMQDNLSPELDDPPNPFTKPIITATQKHHLFSNILEIHIVSGELLKALESRWRENPLIKDLSDILVDFCSEKLKPYVTYLRNQRFQTDTYNKLLNY-PEFLNIIKKFENDPDCSMMNLCSFLMLPMQRVLRLKLLM-TVVKHHIPKGYPTDGCDEAIEALEKLIKECSDEKMVMEQKEEILLICNRLIIKDKMN-VSIGSKP--LLKNGALKVISNNKHASKLLGSSLLNRNNKRAQ--LYLFEDQLIIAKQRKLPLCVSSDDNREVVVDTCQRFNVKFVEISPQKPLSRFNFKLVLSNGMKGSAEYICSVDNPDDLNEWKNAFS----VNKSR----HEEFDFGEAFVICDYTPTSKKEIGLKKGQILNIIKRID 2283
+ R + S+ Q W + K+ +QKL+ + K+QE+ FEV+TSE SY RSL VL +S EL+D + K LFSNIL I VS + LK LE+R E+ ++ D+ DI+ Y+ Y+RNQ +Q TY+ L+ +F +I + + P C + SFL+LP QR+ R+K+L+ ++K + + +A+ A+ K+I+EC+ + M+Q EE++ I N+++ DK+ V I S+ L K G L ++ G +L N K L+LF D L++A ++ R VV+D R V+ + L +L N E + + D++ W AF N+ + +E++D + I Y E+ L+ +I+N+I++ +
Sbjct: 535 GETRSSPIQSSIKQNTLWQDLPSVKESGILQKLTPEECKYQESMFEVMTSEVSYLRSLRVLTEHFLESR-----------------ELND--------TLIVLDKKTLFSNILRIREVSEKFLKDLENRLDESLVVSDICDIISYHAQHNFPAYIDYVRNQIYQDKTYSTLMQTNTQFATVISRLQESPRCQRLPFMSFLLLPFQRITRIKILVENILKRTVEGTDKEESASKALSAVSKIIEECNSQVGKMKQMEELIEI-NKMLEFDKLKAVPIISQTRFLEKRGELLEVAK--------GGTLFNLKPKFTPVCLFLFNDLLVLANKK--------GSERYVVIDHAHRSLVQVQALGENPSLENCFSISLLENHQGRMMERLIKAPSQSDMHRWLAAFPNPEDPNREQEEVIYEDWDCPQVQCIEQYVAKQTDELNLEPPEIINVIRKTN 946
BLAST of Rho guanine nucleotide exchange factor vs. Ensembl Sea Lamprey
Match: ENSPMAT00000000490.1 (pep scaffold:Pmarinus_7.0:GL477825:44699:67115:1 gene:ENSPMAG00000000430.1 transcript:ENSPMAT00000000490.1 gene_biotype:protein_coding transcript_biotype:protein_coding) HSP 1 Score: 132.109 bits (331), Expect = 1.396e-32 Identity = 112/466 (24.03%), Postives = 212/466 (45.49%), Query Frame = 1
Query: 1054 MQKLSEDIIKWQEAQFEVITSEASYYRSLEVLVNKIYKSSWMDCAKEKKNMQDNLSPELDDPPNPFTKPIITATQKHHLFSNILEIHIVSGELLKALESRWRENPLIKDLSDILVDFCSEKLKPYVTYLRNQRFQTDTYNKLL-NYPEFLNIIKKFENDPDCSMMNLCSFLMLPMQRVLRLKLLM-TVVKHHIPKGYPTDGCDEAIEALEKLIKECSDEKMVMEQKEEILLICNRLIIKDKMNVSIGSK--PLLKNGALKVISNNKHASKLLGSSLLNRNNKR-AQLYLFEDQLIIAKQRKLPLCVSSDDNREVVVDTCQRFNVKFVEISPQKPLSRFN----FKLVLSNGMKGSAEYICSVDNPDDLNEWKNAFSVNKSR-------HEEFDFGEAFVICDYTPTSKKEIGLKKGQILNIIKR-----IDNERAIASFSGKQGEILLSCVQYVSTPQPNAEILKE 2388
+ LS D K QEA FEV+TSEASY +S+ ++ + S E+ N N+ K L+S+I ++ V+ + L R + LI D+ DI+ + + K Y+ YL N R+Q + +L + +F +++ + P C + SFL LP+QR+ RL+LL+ ++ +H+ + + ++IKE ++ M+Q EE++ IC +++ ++ + + SK L+K G + ++ G+ +++R ++LF D L+ LC +++ VVVD R +++ P N F ++L N M E + V +P D+ W +A K +E+++ + IC+Y + E+ L++ ++N++++ ++ ER G++G CV+ + A L E
Sbjct: 88 LASLSGDAKKQQEAMFEVLTSEASYLKSISIVTDFFMTS-------EELNQTLNMES------------------KKALYSSIADVKKVTESFIAELGDRIDSDILISDICDIVYKYARDDFKVYIPYLTNNRYQEKKFIELRESNSQFSAAVQRLQEMPQCGRLPFTSFLHLPLQRITRLRLLLENLMSYHVQHRLWYRDRVVLVASRTQVIKESNESVRKMQQVEEMINICQQIVFENVKTIGLISKNRWLVKQGEVMELTQR-------GTMIISRQKATPIHMFLFNDMLL--------LCSKKREHKFVVVDHVHR---AMLQVKPNSDTEVANKNSFFLVLLENHMGKHTEKLLQVSSPSDMERWADAICPPKKETDSSEQIYEDWNCPQVQCICEYKASQLDELSLQEADVINVLRKTADDWMEGERL---SDGEKGWFPAGCVEEIKNTHVRARNLNE 507
BLAST of Rho guanine nucleotide exchange factor vs. Ensembl Sea Lamprey
Match: ENSPMAT00000009516.1 (pep scaffold:Pmarinus_7.0:GL478064:31675:37139:1 gene:ENSPMAG00000008606.1 transcript:ENSPMAT00000009516.1 gene_biotype:protein_coding transcript_biotype:protein_coding) HSP 1 Score: 75.8702 bits (185), Expect = 5.455e-15 Identity = 70/279 (25.09%), Postives = 130/279 (46.59%), Query Frame = 1
Query: 1492 EFLNIIKKFENDPDCSMMNLCSFLMLPMQRVLRLKLLM-TVVKHHIPKGYPTDGCDEAIEALEKLIKECSDEKMVMEQKEEILLICNRLIIKDKMNVSIGSKP---LLKNGALKVISNNKHASKLLGSSLLNR-NNKRAQLYLFEDQLIIAKQRKLPLCVSSDDNREVVVDTCQRFNVKF--VEISPQKPLSRFNFKLVLSNGMKGSAEYICSVDNPDDLNEWKNAFSVNKSRHEEFDFGEAFVIC-------DYTPTSKKEIGLKKGQILNIIKRIDN 2286
+F +++ + DP C+ ++L SFL+LP QR++R+K+L+ ++K P + A++AL +LI+EC++ M++ EE++ + N + DKM P L+K+G L ++ S+ GS+L+NR KR L+LF D LI+++++ + V R V+ V + + +F L+L + + + + W A + + + E E C Y E+ L KG IL+I ++ +
Sbjct: 4 KFSPLLEHLQEDPICNRLSLQSFLILPFQRIVRIKILLENILKKTEPHSRYEETASVALKALARLIQECNENARKMKRTEELIHLHNTIEF-DKMKSLALISPTRWLVKHGELLELA----VSRTAGSTLMNRLMTKRIYLHLFNDILILSRRK-------DSGGKFTVFCHADRTKVELQSVGAAENNVATDNSFYLLLDDHDSRKYRLLLRAASQSEKERWVEAIAPPQRKDEAALVYEGVTDCPQVYCLKAYVAQEPDELSLDKGDILSITRKTSD 270
BLAST of Rho guanine nucleotide exchange factor vs. Ensembl Sea Lamprey
Match: ENSPMAT00000007206.1 (pep scaffold:Pmarinus_7.0:GL501079:1421:14838:1 gene:ENSPMAG00000006509.1 transcript:ENSPMAT00000007206.1 gene_biotype:protein_coding transcript_biotype:protein_coding) HSP 1 Score: 53.9138 bits (128), Expect = 7.846e-8 Identity = 78/318 (24.53%), Postives = 133/318 (41.82%), Query Frame = 1
Query: 1495 FLNIIKKFENDPDCSMMNLCSFLMLPMQRVLRLKLLMTVVKHHIPKGYPTDGCDE-AIEALEKLIKECSDEKMVMEQKEEILLICNRLIIKDKMN---VSIGSKPLLKNGALKVISNNKHASKLLGSSLLNRNNKRAQLYLFEDQLIIAKQRKLPLCVSSDDNREVVVDTCQRFNVKFVEISPQKPLSRFNFKLVLSNGMKG-SAEYICSVDNPDDLNE--WKNAFSVNKSRHEEFDFGEAFVI-C--DYTPTSKKEIGLKKGQILNIIKR-----IDNERAIASFSGKQGEILLSCVQYVSTPQPNAEILKEIRLSI 2403
F + IK E P C + SFL +P QR+ R +LL+ V + + E A+ LE+L+++ Q E+++ I N + + M + S+ LLK+G L V K + + + L LF D LI+A ++K R +V+D R V E F L L + +G AE++ + N L W + R + V+ C DY E+ L++ +L +I++ ++ ER SG +G S V+ +++ +A L+E +LS+
Sbjct: 6 FSSKIKLLEEAPVCEKLPFLSFLSVPYQRITRYQLLVKNVISKAEESVESGNVVELALSKLEELVQQSDKGVGERTQAEQVVNIANNIYFEKGMKSLAIVSQSRSLLKSGKLLVQEKAKTIIP-MAVARFTQGKTYVMLLLFNDFLIVATKQK--------GGRLLVLDYADRAFVMAAEAEGNSD----AFLLTLMDNHQGKQAEWLLAASNTPRLYRRWWFDESCTPPPRPARAAAADCPVVQCVRDYVALEIDELNLREEDVLCVIRKTPDGWMEGERL---RSGDRGWFPASHVEEIASHHVDARNLREHKLSL 307
BLAST of Rho guanine nucleotide exchange factor vs. Ensembl Sea Lamprey
Match: ENSPMAT00000000535.1 (pep scaffold:Pmarinus_7.0:GL480899:1793:11000:-1 gene:ENSPMAG00000000475.1 transcript:ENSPMAT00000000535.1 gene_biotype:protein_coding transcript_biotype:protein_coding) HSP 1 Score: 48.9062 bits (115), Expect = 3.419e-6 Identity = 51/190 (26.84%), Postives = 82/190 (43.16%), Query Frame = 1
Query: 1102 EVITSEASYYRSLEVLVNKIYKSSWMDCAKEKKNMQDNLSPELDDPPNPFTKPIITATQKHHLFSNILEIHIVSGE-LLKALESR---WRENPLIKDLSDILVDFCSEKLKPYVTYLR---NQRFQTDTYNKLLNYPEFLNIIKKFENDPDCSMMNLCSFLMLPMQRVLRLKLLMTVVKHHIPKGYPTDG 1650
E++T+E +Y + L++L Y L + N + P+ T +H+FSNI IH+ E LL LE R W E P I D+ L F L Y Y+R DT+++ P+F II + + + ++L ++ P+QR+ R +LL+ +P P G
Sbjct: 14 ELLTTERNYVQRLQLLDKAFY-------------------ARLLEEANRGSFPVETI---NHIFSNISSIHLFHKEFLLPQLEGRMEAWEETPRIGDILQKLAPF----LMMYGEYVRCFDRAMELVDTWSQ--RSPQFKKIITEVQMQKESGCLSLQHHMLEPVQRIPRYELLLKDYLRRLPLDSPDRG 175
BLAST of Rho guanine nucleotide exchange factor vs. Ensembl Sea Lamprey
Match: net1 (neuroepithelial cell transforming 1 [Source:ZFIN;Acc:ZDB-GENE-041121-18]) HSP 1 Score: 48.521 bits (114), Expect = 5.597e-6 Identity = 49/226 (21.68%), Postives = 90/226 (39.82%), Query Frame = 1
Query: 1018 WAETEEGKKLINMQKLSEDIIKWQEAQFEVITSEASYYRSLEVLVNKIYKSSWMDCAKEKKNMQDNLSPELDDPPNPFTKPIITATQKHHLFSNILEIHIVSGELLKALESRWRENPLIKDLSDILVDFCSEKLKPYVTYLRNQRFQTDTYNKLLNYPEFLNIIKKFENDPDCSMMNLCSFLMLPMQRVLRLKLLMTVVKHHIPKGYPTDGC-DEAIEALEKLIKE 1692
W+ET + + S IK QEA FE+ E L+ L K Y+ + + I+TA + +F + + + +LL L+ + N + + ILV++ L Y Y NQ ++ P + +++ P + L SFL +P R+++ LL+ + H P +P C +EAI ++ ++ +
Sbjct: 93 WSETYDAGA---HEAFSRSEIKRQEAIFELAQGEQDLIEDLK-LAKKAYRDPMLKLS------------------------IMTAVELAQIFGALDSLIPLHEDLLTGLQKARKPNGATERVGHILVEWLP-CLNAYTCYCANQVAAKALLDQKKQDPRVQDFLQRCLESPFSRKLELWSFLDVPRSRLVKYPLLLREILRHTPNEHPDQQCLEEAISIIQGVVAD 289
BLAST of Rho guanine nucleotide exchange factor vs. Ensembl Yeast
Match: ROM2 (Guanine nucleotide exchange factor (GEF) for Rho1p and Rho2p; mutations are synthetically lethal with mutations in rom1, which also encodes a GEF; Rom2p localization to the bud surface is dependent on Ack1p; ROM2 has a paralog, ROM1, that arose from the whole genome duplication [Source:SGD;Acc:S000004363]) HSP 1 Score: 55.4546 bits (132), Expect = 4.374e-8 Identity = 68/297 (22.90%), Postives = 140/297 (47.14%), Query Frame = 1
Query: 1078 IKWQEAQFEVITSEASYYRSLEVLVNKIYKSSWMDCAKEKKNMQDNLSPELDDPPNPFTKPIITATQKHHLFSNILEIHIVSGELLKALESRWRENPLIKDLSDILVDFCSEKLKPYVTYLRNQ---RFQTDTYNKLLNYPEFLNIIKKFENDPDCSMM--NLCSFLMLPMQRVLRLKLLMT-VVKHHIPKGYPTDGCD--EAIEALEKLIKECSDEKMVMEQKEEILLICNRLIIKDKMNVSIGSKPLLKNGALKVISNNKHASKLLGSSLLNRNNKRAQLYLFEDQLIIAKQRKL 1944
IK QEA +EV +E ++ +SLE I + ++M E + ++ F K H+F++I +I+ V+ LKAL R R +P+++ + DI++ F +P+V+Y+ ++ ++ +T + Y +F++D S + + SFL + R R LL+ ++K P+ +D D +A++AL +K + + ++ L+ +++ K++ V++G + + I + K SK G+ + + Q YL ++ L+ K + +
Sbjct: 658 IKRQEAIYEVYITEKNFVKSLE-----ITRDTFMKTLAETNIISADIRKN-------FIK---------HVFAHINDIYSVNRRFLKALTDRQRSSPVVRGIGDIVLRFI-PFFEPFVSYVASRPYAKYLIETQRSVNPY------FARFDDDMMSSSLRHGIDSFLSQGVSRPGRYMLLVKEIMKSTDPEKDKSDYEDLSKAMDALRDFMKRIDQASGAAQDRHDVKLLKQKILFKNEY-VNLGLNDERRKIKHEGILSRKELSKSDGTVVGD-----IQFYLLDNMLLFLKAKAV 920
BLAST of Rho guanine nucleotide exchange factor vs. Ensembl Yeast
Match: ROM1 (Guanine nucleotide exchange factor (GEF) for Rho1p; mutations are synthetically lethal with mutations in rom2, which also encodes a GEP; ROM1 has a paralog, ROM2, that arose from the whole genome duplication [Source:SGD;Acc:S000003302]) HSP 1 Score: 50.0618 bits (118), Expect = 1.825e-6 Identity = 38/133 (28.57%), Postives = 71/133 (53.38%), Query Frame = 1
Query: 1057 QKLSEDIIKWQEAQFEVITSEASYYRSLEVLVNKIYKSSWMDCAKEKKNMQDNLSPELDDPPNPFTKPIITATQKHHLFSNILEIHIVSGELLKALESRWRENPLIKDLSDILVDFCSEKLKPYVTYLRNQRF 1455
+ LS+ IK QEA +E+ T+E + +SLE++ + ++M KK ++ N+ P D F K H+F++I EI+ V+ E LKAL R +P+ ++DI + + P+++Y+ ++ +
Sbjct: 456 ESLSKQQIKRQEAIYELFTTEKKFVKSLEII-----RDTFM-----KKLLETNIIPS--DVRINFVK---------HVFAHINEIYSVNREFLKALAQRQSLSPICPGIADIFLQYLPF-FDPFLSYIASRPY 566
BLAST of Rho guanine nucleotide exchange factor vs. Ensembl Nematostella
Match: EDO39595 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7S9L2]) HSP 1 Score: 133.265 bits (334), Expect = 6.643e-33 Identity = 113/434 (26.04%), Postives = 208/434 (47.93%), Query Frame = 1
Query: 1018 WAETEEGKKLINMQKLSEDIIKWQEAQFEVITSEASYYRSLEVLVNKIYKSSWMDCAKEKKNMQDNLSPELDDPPNPFTKPIITATQKHHLFSNILEIHIVSGELLKALESRWRENPLIKDLSDILVDFCSEKLKPYVTYLRNQRFQTDTYNKLLNYPEFLNIIKKFENDPDCSMMNLCSFLMLPMQRVLRLKLLMTVVKHHIPKGYPTD---GCDEAIEALEKLIKECSDEKMVMEQKEEILLICNRLIIKDKMNVSIGS-KPLLKNGALKVISNNKHASKLLGSSLLNR-NNKRAQLYLFEDQLIIAKQRKLPLCVSSDDNREVVVDTCQRFNVKFVEIS--PQKPLSRFNFKLVLSNGMKGSAEYICSVDNPDDLNEWKNAFSVNKSRHE------EFDFGEAFVICDYTPTSKKEIGLKKGQILNIIKRI 2280
W E E K ++ + K QEA FEVITSEASY +SL +L S +MD SPEL + ++ +Q+ LF N+ + S + L AL R R++ +I +SDI+ + ++ Y+ Y +Q +Q +L P F+ +++ E ++ SFL+LPMQR+ RL LL+ + H +G +D D+A++++ K++ +C++ ME+ EE++ + + K + S + LL+ G + +++ S L + K ++LF D L++ K++ D + V+D R N+ VE++ P + ++L N + +++ ++ D W +AFS K+ HE +D + I +YTP E+ L +G ++N+++++
Sbjct: 3 WCELPEVMKSGVLETIDPTERKRQEAMFEVITSEASYLKSLNIL-----GSHFMD------------SPELQADT---AQSVVEKSQQRVLFGNVKGVLEASEKFLTALRQRQRKSYVISTISDIIEEHATQYFDIYIKYCSHQVYQDRILKELGKNPRFVEAVRRLEQCSTAQCLSFQSFLVLPMQRITRLPLLVDAICHRCEEG--SDEFVRTDKALKSINKVVHDCNEGARKMERMEELIALQPLIEFAVKPVALVSSNRWLLRRGEVLLVTEE------FKSPLRKKIKTKPVYMFLFNDLLLMCKKK--------SDIKYRVLDYANR-NMTKVEVANEPSIQMKYLLSLILLENSNGKTKDFLICAESETDKTRWLDAFSPPKAEHEGERVYGAWDCPQVQAIHNYTPQQPDELALHEGDVINVLRKL 399
BLAST of Rho guanine nucleotide exchange factor vs. Ensembl Nematostella
Match: EDO48185 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7RK39]) HSP 1 Score: 62.003 bits (149), Expect = 2.264e-10 Identity = 51/194 (26.29%), Postives = 96/194 (49.48%), Query Frame = 1
Query: 1288 LFSNILEIHIVSGE-LLKALESR---WRENPLIKDLSDILVDFCSEKLKPYVTYLRNQRFQTDTYNKLLN-YPEFLNIIKKFENDPDCSMMNLCSFLMLPMQRVLRLKLLMTVVKHHIPKGYP-TDGCDEAIEALEKLIKECSDEKMVMEQKEEILLICNRLIIKDKMNVSIGSKPLLKNGALKVISNNKHASK 1851
+F+NI IH + LL LE R W N + D+ L F LK Y Y+ N +T + L P+F ++I + + P+ + L ++ P+QRV R KLL+T + +P+ P + +A+ + K ++ ++ E+ +++L I RL+ ++ ++ S+ +K G ++ +S KH +
Sbjct: 5 IFANIGSIHKFHSDFLLPKLEERMAQWTTNNTLGDILKTLAPF----LKMYSAYVGNFDKANETVSVWLKKLPKFASVINEIQRSPESENLTLQHHMLEPIQRVPRYKLLLTDYINKLPEDSPDVNATKDALAIVSKAAQQSNEIMKKTERFQKLLEIQERLL--EQSDIITPSREFVKEGVIRKVSARKHVGQ 192
BLAST of Rho guanine nucleotide exchange factor vs. Ensembl Medaka
Match: ARHGEF26 (Rho guanine nucleotide exchange factor 26 [Source:NCBI gene;Acc:101154796]) HSP 1 Score: 153.68 bits (387), Expect = 1.230e-37 Identity = 145/503 (28.83%), Postives = 229/503 (45.53%), Query Frame = 1
Query: 913 DEDNDSIELEPNIDNDSFADNRVFQLFSATSQRLRWAETEEGKKLINMQKLSEDIIKWQEAQFEVITSEASYYRSLEVLVNKIYKSSWMDCAKEKKNMQDNLSPELDDPPNPFTKPIITATQKHHLFSNILEIHIVSGELLKALESRWRENPLIKDLSDILVDFCSEKLKPYVTYLRNQRFQTDTYNKLLNY-PEFLNIIKKFENDPDCSMMNLCSFLMLPMQRVLRLKLLMTVVKHHIPK-GYPTDGCDEAIEALEKLIKECSDEKMVMEQKEEILLICNRLIIKDKMNVSIGSKPLLKNGALKVISNNKHASKLLGSSLLNRNNKRAQLY--LFEDQLIIAKQRKLPLCVSSDDNREVVVDTCQRFNVKFVEISPQ--------KPLSRFNFKLVLSNGMKGSAEYICSVDNPDDLNE---WKNAFSVNKSRHEEFDFGEAF---VICDYTPTSKKEIGLKKGQILNIIKRID----NERAIASFSGKQGEILLSCVQYVS 2355
DED D+ E++P+ D V Q R W++ KK +KLS++ K QEA FE+I+SE SY+ SLE+L+ +++K D A+ ++ M + Q HHLFSNI ++ S E K LE R +N +I D+SDI+ P++TY N+ +Q T KLL+ P F ++ K E PDC + + SFL+LPMQR+ RL LLM + PK + C A++ + K++++C++ ME+ E ++C I ++ I PL+ + V + L+ L R R LY LF D LII +++ S+D+ VVD R + P +P S F L + G E + + + LNE W +A N + ++ D A VI YT E+ L+ ++ + + +D ER G++G L C ++
Sbjct: 463 DEDADAREIKPD-------DCIVVQYRPL---RTTWSQLTVVKKSGLSEKLSQEERKRQEAIFELISSEHSYFHSLEILI-RLFK----DSAELRETM--------------------SKMQHHHLFSNISDVCEASKEFFKELEERHEKNIVISDISDIVCKHAQSNFDPFITYCSNEVYQQRTLQKLLSTNPTFKEVLTKIEAHPDCRNLPMISFLILPMQRITRLPLLMDTICQKTPKTSRQYEDCKTALQEISKVVRKCNEGARTMERTE---MLCT---INSQLEFKIKPFPLISSSRWMV--KRGEVTSLVEGVFLKRTT-RQHLYLLLFNDVLIITRKK-------SEDSY-TVVDYALRDEISVSLYQPDDLKTMLSPRPSSNHLFHLHFEHNHSG--EKMHRILGTESLNERARWISALGQNPNNKDQ-DRSNAIQVEVIRTYTARQPDELSLQVADVVLVSQTVDGWYEGERL---RDGERGWFLAECAVQIT 907
BLAST of Rho guanine nucleotide exchange factor vs. Ensembl Medaka
Match: arhgef16 (rho guanine nucleotide exchange factor 16 [Source:NCBI gene;Acc:101175237]) HSP 1 Score: 149.058 bits (375), Expect = 1.287e-36 Identity = 133/479 (27.77%), Postives = 220/479 (45.93%), Query Frame = 1
Query: 1009 RLRWAETEEGKKLINMQKLSEDIIKWQEAQFEVITSEASYYRSLEVLVNKIYKSSWMDCAKEKKNMQDNLSPELDDPPNPFTKPIITATQKHHLFSNILEIHIVSGELLKALESRWRENPLIKDLSDILVDFCSEKLKPYVTYLRNQRFQTDTYNKLLNY-PEFLNIIKKFENDPDCSMMNLCSFLMLPMQRVLRLKLLMTVVKHHIPKGYPTD-GCDEAIEALEKLIKECSDEKMVMEQKEEILLICNRL---IIKDKMNVSIGSKPLLKNGALKVISNNKHASKLLGSSLLNRNNKRAQLYLFEDQLIIAKQRKLPLCVSSDDNREVVVDTCQRFNVKFV-----EISPQKPLSRFNFKLVLSNGMKGSAEYICSV-DNPDDLNEWKNAFSVNKSRHEEFDFG--EAFVICDYTPTSKKEIGLKKGQILNIIKRIDNE-RAIASFSGKQGEILLSCVQYVSTP---QPNAEILKEIR 2394
+L W++ + K + +++ K QEA FE+I SE SY SL +LV K K + ++P T+ HHLFSNI I VS + LE R +E+ +I+D+SDI+ + + +PY+ Y N+ FQ T+ KLLN F +K+ E+ +C + + SFL+LPMQRV RL LL+ + P+ A+ A+ KL+ C+D ME+ E++ I ++ IK VS S+ L K G L + + K N+ L+LF D LI+ K++ + V D T + V++V ++S + FKL+++ G +E I V D+ D W A + +K + G + Y P EIGL++ +++ ++K+ + A G++G SC ++ P + N + +K +R
Sbjct: 257 QLTWSQLPQVKNSDILSRITPQERKRQEAIFEIICSEHSYLHSLGILVRHF---------KNSKTLSKTMAP----------------TEHHHLFSNISVILKVSQRFFEDLERRHQEDVVIRDISDIIQNHAAHHFEPYIAYCSNETFQQRTHQKLLNTNSAFKEALKQLESSSECGGLPMFSFLILPMQRVTRLPLLLDTICQKTPENTAEYFAAVWALHAMSKLVTSCNDGARRMERTEQMYTIQKQMDFGKIKPFPLVS-SSRWLKKRGELNISAEELSIWKAF-------TNRSYYLFLFNDVLIVTKKKTEEIFVVLD------YATLENVEVEYVMETDGQMSSPTKSTPLTFKLLMTKNSDGRSEQISLVADSRVDRARWIIALTEHKQANATCTEGLPQYEATKSYIPKEPDEIGLRQAELVLVMKKEEAWCYAERMRDGERGWFPASCATEITNPTAMESNVQQMKRLR 696
BLAST of Rho guanine nucleotide exchange factor vs. Ensembl Medaka
Match: arhgef16 (rho guanine nucleotide exchange factor 16 [Source:NCBI gene;Acc:101175237]) HSP 1 Score: 149.058 bits (375), Expect = 1.287e-36 Identity = 133/479 (27.77%), Postives = 220/479 (45.93%), Query Frame = 1
Query: 1009 RLRWAETEEGKKLINMQKLSEDIIKWQEAQFEVITSEASYYRSLEVLVNKIYKSSWMDCAKEKKNMQDNLSPELDDPPNPFTKPIITATQKHHLFSNILEIHIVSGELLKALESRWRENPLIKDLSDILVDFCSEKLKPYVTYLRNQRFQTDTYNKLLNY-PEFLNIIKKFENDPDCSMMNLCSFLMLPMQRVLRLKLLMTVVKHHIPKGYPTD-GCDEAIEALEKLIKECSDEKMVMEQKEEILLICNRL---IIKDKMNVSIGSKPLLKNGALKVISNNKHASKLLGSSLLNRNNKRAQLYLFEDQLIIAKQRKLPLCVSSDDNREVVVDTCQRFNVKFV-----EISPQKPLSRFNFKLVLSNGMKGSAEYICSV-DNPDDLNEWKNAFSVNKSRHEEFDFG--EAFVICDYTPTSKKEIGLKKGQILNIIKRIDNE-RAIASFSGKQGEILLSCVQYVSTP---QPNAEILKEIR 2394
+L W++ + K + +++ K QEA FE+I SE SY SL +LV K K + ++P T+ HHLFSNI I VS + LE R +E+ +I+D+SDI+ + + +PY+ Y N+ FQ T+ KLLN F +K+ E+ +C + + SFL+LPMQRV RL LL+ + P+ A+ A+ KL+ C+D ME+ E++ I ++ IK VS S+ L K G L + + K N+ L+LF D LI+ K++ + V D T + V++V ++S + FKL+++ G +E I V D+ D W A + +K + G + Y P EIGL++ +++ ++K+ + A G++G SC ++ P + N + +K +R
Sbjct: 257 QLTWSQLPQVKNSDILSRITPQERKRQEAIFEIICSEHSYLHSLGILVRHF---------KNSKTLSKTMAP----------------TEHHHLFSNISVILKVSQRFFEDLERRHQEDVVIRDISDIIQNHAAHHFEPYIAYCSNETFQQRTHQKLLNTNSAFKEALKQLESSSECGGLPMFSFLILPMQRVTRLPLLLDTICQKTPENTAEYFAAVWALHAMSKLVTSCNDGARRMERTEQMYTIQKQMDFGKIKPFPLVS-SSRWLKKRGELNISAEELSIWKAF-------TNRSYYLFLFNDVLIVTKKKTEEIFVVLD------YATLENVEVEYVMETDGQMSSPTKSTPLTFKLLMTKNSDGRSEQISLVADSRVDRARWIIALTEHKQANATCTEGLPQYEATKSYIPKEPDEIGLRQAELVLVMKKEEAWCYAERMRDGERGWFPASCATEITNPTAMESNVQQMKRLR 696
BLAST of Rho guanine nucleotide exchange factor vs. Ensembl Medaka
Match: arhgef19 (Rho guanine nucleotide exchange factor 19 [Source:NCBI gene;Acc:101169904]) HSP 1 Score: 134.806 bits (338), Expect = 9.900e-32 Identity = 119/428 (27.80%), Postives = 194/428 (45.33%), Query Frame = 1
Query: 1018 WAETEEGKKLINMQKLSEDIIKWQEAQFEVITSEASYYRSLEVLVNKIYKSSWMDCAKEKKNMQDNLSPELDDPPNPFTKPIITATQKHHLFSNILEIHIVSGELLKALESRWRENPLIKDLSDILVDFCSEKLKPYVTYLRNQRFQTDTYNKLLNY-PEFLNIIKKFENDPDCSMMNLCSFLMLPMQRVLRLKLLM-TVVKHHIPKGYPTDGCDEAIEALEKLIKECSDEKMVMEQKEEILLICNRLIIKDKMNVSIG-SKPLLKNGALKVISNNKHASKLLGSSLLNRNNKRAQLYLFEDQLIIAKQR---KLPLCVSSDDNREVVVDTCQRFNVKFVEISPQKPLSRFNFKLVLSNGMKGSAEYICSVDNPDDLNEWKNA-FSVN-----KSRHEEFDFGEAFVICDYTPTSKKEIGLKKGQILN 2265
W + + + + S++ K QEA+FE++TSEASY RSL + V+ LS EL + + A +K LFS + E+ VS L LE R E+ L D+ DI++D C+ + Y+ Y+ NQ +Q TY +LL P F I+ + E D C + L SFL+LP QR+ RLK+L+ ++K P D +A L+K+I+EC+ M++ EE++ + ++ + K+ I S+ L+K+G L + + + S L K L+LF D L++++++ K + V + V D Q+ + +S F F L L G + + + W A F N + E D + I Y E+ L+K IL+
Sbjct: 506 WQDIPDVRTSGQLDHFSKEERKLQEAKFELVTSEASYIRSLTIAVDHFM-----------------LSQELAE--------CLGAQEKQWLFSKLPEVKDVSERFLLDLERRLEEDILRFDVCDIVLDHCTALRRVYLPYVTNQAYQEQTYQRLLQENPRFPGILARLEEDAVCQRLPLTSFLILPFQRITRLKMLVENILKRTAPGSRDEDTATKAFNELKKIIRECNSSVQSMKRMEELIHLNKKIHFEGKIFPLISQSRWLVKHGELLEVDTPMMS---ISGSKLKLPTKPVYLHLFNDCLLLSRRKETWKFMVFVHAKIGELKVKDLSQKL----------QGISGFIFHLQLCEGQQLKHQILLKSHTESGKQRWITAMFPSNPLEDIEQATENDDISQVQCIKSYQAQEHDELTLEKADILH 895
BLAST of Rho guanine nucleotide exchange factor vs. Ensembl Medaka
Match: arhgef19 (Rho guanine nucleotide exchange factor 19 [Source:NCBI gene;Acc:101169904]) HSP 1 Score: 134.035 bits (336), Expect = 1.899e-31 Identity = 119/428 (27.80%), Postives = 194/428 (45.33%), Query Frame = 1
Query: 1018 WAETEEGKKLINMQKLSEDIIKWQEAQFEVITSEASYYRSLEVLVNKIYKSSWMDCAKEKKNMQDNLSPELDDPPNPFTKPIITATQKHHLFSNILEIHIVSGELLKALESRWRENPLIKDLSDILVDFCSEKLKPYVTYLRNQRFQTDTYNKLLNY-PEFLNIIKKFENDPDCSMMNLCSFLMLPMQRVLRLKLLM-TVVKHHIPKGYPTDGCDEAIEALEKLIKECSDEKMVMEQKEEILLICNRLIIKDKMNVSIG-SKPLLKNGALKVISNNKHASKLLGSSLLNRNNKRAQLYLFEDQLIIAKQR---KLPLCVSSDDNREVVVDTCQRFNVKFVEISPQKPLSRFNFKLVLSNGMKGSAEYICSVDNPDDLNEWKNA-FSVN-----KSRHEEFDFGEAFVICDYTPTSKKEIGLKKGQILN 2265
W + + + + S++ K QEA+FE++TSEASY RSL + V+ LS EL + + A +K LFS + E+ VS L LE R E+ L D+ DI++D C+ + Y+ Y+ NQ +Q TY +LL P F I+ + E D C + L SFL+LP QR+ RLK+L+ ++K P D +A L+K+I+EC+ M++ EE++ + ++ + K+ I S+ L+K+G L + + + S L K L+LF D L++++++ K + V + V D Q+ + +S F F L L G + + + W A F N + E D + I Y E+ L+K IL+
Sbjct: 506 WQDIPDVRTSGQLDHFSKEERKLQEAKFELVTSEASYIRSLTIAVDHFM-----------------LSQELAE--------CLGAQEKQWLFSKLPEVKDVSERFLLDLERRLEEDILRFDVCDIVLDHCTALRRVYLPYVTNQAYQEQTYQRLLQENPRFPGILARLEEDAVCQRLPLTSFLILPFQRITRLKMLVENILKRTAPGSRDEDTATKAFNELKKIIRECNSSVQSMKRMEELIHLNKKIHFEGKIFPLISQSRWLVKHGELLEVDTPMMS---ISGSKLKLPTKPVYLHLFNDCLLLSRRKETWKFMVFVHAKIGELKVKDLSQKL----------QGISGFIFHLQLCEGQQLKHQILLKSHTESGKQRWITAMFPSNPLEDIEQATENDDISQVQCIKSYQAQEHDELTLEKADILH 895
BLAST of Rho guanine nucleotide exchange factor vs. Planmine SMEST
Match: SMESG000003891.1 (SMESG000003891.1) HSP 1 Score: 764.992 bits (1974), Expect = 0.000e+0 Identity = 397/401 (99.00%), Postives = 398/401 (99.25%), Query Frame = 1
Query: 37 LPEIKKHWVSDLTIFFENFSKHRNSIKKNKRLSAEKKKSELIKTTMDYNIQNSSVEHCCTVERAKQIFDTHNAICGNQSNSFDEHFCSVIQDKKAIGXXXXXXXXXXXXXXXQCSFKNVSLFDIFSGNAVDFDIPSIESDNEEEDPRANSNFNKKINNSQLSKRKRSNPMKSNFYGNRKGHEKKQSIGKTFIPTSDADKENEGVLIRMRNQESYYDGKDKYQSQLPEAPLYQVYENIRQRRSNFAQKAHEKPIDPTDYELNNDAIQNSIIFPRTSLPSVDENCKFQERTTTRDEDNDSIELEPNIDNDSFADNRVFQLFSATSQRLRWAETEEGKKLINMQKLSEDIIKWQEAQFEVITSEASYYRSLEVLVNKIYKSSWMDCAKEKKNMQDNLSPELDDP 1239
+PEIKKHWVSDLTIFFENFSKHRNSIKKNKRLSAEKKKSELIKTTMDYNIQNSSVEHCCTVERAKQIFDTHNAICGNQSNSFDEHFCSVIQDKKAIGKSNSVSTTDSNTDKSQ SFKNVSLFDIFSGNAVDFDIPSIESDNEEEDPRANSNFN KINNSQLSKRKRSNPMKSNFYGNRKGHEKKQSIGKTFIPTSDADKENEGVLIRMRNQESYYDGKDKYQSQLPEAPLYQVYENIRQRRSNFAQKAHEKPIDPTDYELNNDAIQNSIIFPRTSLPSVDENCKFQERTTTRDEDNDSIELEPNIDNDSFADNRVFQLFSATSQRLRWAETEEGKKLI MQKLSEDIIKWQEAQFEVITSEASYYRSLEVLVNKIYKSSWMDCAKEKKNMQDNLSPELDDP
Sbjct: 10 VPEIKKHWVSDLTIFFENFSKHRNSIKKNKRLSAEKKKSELIKTTMDYNIQNSSVEHCCTVERAKQIFDTHNAICGNQSNSFDEHFCSVIQDKKAIGKSNSVSTTDSNTDKSQSSFKNVSLFDIFSGNAVDFDIPSIESDNEEEDPRANSNFNNKINNSQLSKRKRSNPMKSNFYGNRKGHEKKQSIGKTFIPTSDADKENEGVLIRMRNQESYYDGKDKYQSQLPEAPLYQVYENIRQRRSNFAQKAHEKPIDPTDYELNNDAIQNSIIFPRTSLPSVDENCKFQERTTTRDEDNDSIELEPNIDNDSFADNRVFQLFSATSQRLRWAETEEGKKLIKMQKLSEDIIKWQEAQFEVITSEASYYRSLEVLVNKIYKSSWMDCAKEKKNMQDNLSPELDDP 410
BLAST of Rho guanine nucleotide exchange factor vs. Planmine SMEST
Match: SMESG000003902.1 (SMESG000003902.1) HSP 1 Score: 752.666 bits (1942), Expect = 0.000e+0 Identity = 372/389 (95.63%), Postives = 378/389 (97.17%), Query Frame = 1
Query: 1273 TQKHHLFSNILEI----HIVSGELLKALESRWRENPLIKDLSDILVDFCSEKLKPYVTYLRNQRFQTDTYNKLLNYPEFLNIIKKFENDPDCSMMNLCSFLMLPMQRVLRLKLLMTVVKHHIPKGYPTDGCDEAIEALEKLIKECSDEKMVMEQKEEILLICNRLIIKDKMNVSIGSKPLLKNGALKVISNNKHASKLLGSSLLNRNNKRAQLYLFEDQLIIAKQRKLPLCVSSDDNREVVVDTCQRFNVKFVEISPQKPLSRFNFKLVLSNGMKGSAEYICSVDNPDDLNEWKNAFSVNKSRHEEFDFGEAFVICDYTPTSKKEIGLKKGQILNIIKRIDNERAIASFSGKQGEILLSCVQYVSTPQPNAEILKEIRLSICSRNNNQY 2427
TQ+++ S+I EI + +LLKALESRWRENPLIKDLSDILVDFCSEKLKPYVTYLRNQRFQTDTYNKLLNYPEFLNIIKKFENDPDCSMMNLCSFLMLPMQRVLRLKLLMTVVKHHIPKGYPTDGCDEAIEALEKLIKECSDEKMVMEQKEEILLICNRLIIKDKMNVSIGSKPLLKNGALKVISNNKHASKLLGSSLLNRNNKRAQLYLFEDQLIIAKQRKLPLCVSSDDNREVVVDTCQRFNVKFVEISPQKPLSRFNFKLVLSNGMKGSAEYICSVDNPDDLNEWKNAFSVNKSRHEEFDFGEAFVICDYTPTSKKEIGLKKGQILNIIKRIDNERAIASFSGKQGEILLSCVQYVSTPQPNAEILKEIRLSICSRNNNQY
Sbjct: 13 TQQNNTLSSI-EIWKLKMLYMAKLLKALESRWRENPLIKDLSDILVDFCSEKLKPYVTYLRNQRFQTDTYNKLLNYPEFLNIIKKFENDPDCSMMNLCSFLMLPMQRVLRLKLLMTVVKHHIPKGYPTDGCDEAIEALEKLIKECSDEKMVMEQKEEILLICNRLIIKDKMNVSIGSKPLLKNGALKVISNNKHASKLLGSSLLNRNNKRAQLYLFEDQLIIAKQRKLPLCVSSDDNREVVVDTCQRFNVKFVEISPQKPLSRFNFKLVLSNGMKGSAEYICSVDNPDDLNEWKNAFSVNKSRHEEFDFGEAFVICDYTPTSKKEIGLKKGQILNIIKRIDNERAIASFSGKQGEILLSCVQYVSTPQPNAEILKEIRLSICSRNNNQY 400
BLAST of Rho guanine nucleotide exchange factor vs. Planmine SMEST
Match: SMESG000003902.1 (SMESG000003902.1) HSP 1 Score: 729.939 bits (1883), Expect = 0.000e+0 Identity = 364/389 (93.57%), Postives = 371/389 (95.37%), Query Frame = 1
Query: 1273 TQKHHLFSNILEI----HIVSGELLKALESRWRENPLIKDLSDILVDFCSEKLKPYVTYLRNQRFQTDTYNKLLNYPEFLNIIKKFENDPDCSMMNLCSFLMLPMQRVLRLKLLMTVVKHHIPKGYPTDGCDEAIEALEKLIKECSDEKMVMEQKEEILLICNRLIIKDKMNVSIGSKPLLKNGALKVISNNKHASKLLGSSLLNRNNKRAQLYLFEDQLIIAKQRKLPLCVSSDDNREVVVDTCQRFNVKFVEISPQKPLSRFNFKLVLSNGMKGSAEYICSVDNPDDLNEWKNAFSVNKSRHEEFDFGEAFVICDYTPTSKKEIGLKKGQILNIIKRIDNERAIASFSGKQGEILLSCVQYVSTPQPNAEILKEIRLSICSRNNNQY 2427
TQ+++ S+I EI + +LLKALESRWRENPLIKDLSDILVDFCSEKLKPYVTYLRNQRFQTDTYNKLLNYPEFLNIIKKFENDPDCSMMNLCSFLMLPMQRVLRLKLLMTVVKHHIPKGYPTDGCDEAIEALEKLIKECSDEKMVMEQKEEILLICNRLIIKDKMNVSIGSKPLLKNGALKVISNNKHASKLLGSSLLNRNNKRAQLYLFEDQLIIAKQR +DDNREVVVDTCQRFNVKFVEISPQKPLSRFNFKLVLSNGMKGSAEYICSVDNPDDLNEWKNAFSVNKSRHEEFDFGEAFVICDYTPTSKKEIGLKKGQILNIIKRIDNERAIASFSGKQGEILLSCVQYVSTPQPNAEILKEIRLSICSRNNNQY
Sbjct: 13 TQQNNTLSSI-EIWKLKMLYMAKLLKALESRWRENPLIKDLSDILVDFCSEKLKPYVTYLRNQRFQTDTYNKLLNYPEFLNIIKKFENDPDCSMMNLCSFLMLPMQRVLRLKLLMTVVKHHIPKGYPTDGCDEAIEALEKLIKECSDEKMVMEQKEEILLICNRLIIKDKMNVSIGSKPLLKNGALKVISNNKHASKLLGSSLLNRNNKRAQLYLFEDQLIIAKQR-------NDDNREVVVDTCQRFNVKFVEISPQKPLSRFNFKLVLSNGMKGSAEYICSVDNPDDLNEWKNAFSVNKSRHEEFDFGEAFVICDYTPTSKKEIGLKKGQILNIIKRIDNERAIASFSGKQGEILLSCVQYVSTPQPNAEILKEIRLSICSRNNNQY 393
BLAST of Rho guanine nucleotide exchange factor vs. Planmine SMEST
Match: SMESG000003902.1 (SMESG000003902.1) HSP 1 Score: 727.628 bits (1877), Expect = 0.000e+0 Identity = 358/366 (97.81%), Postives = 359/366 (98.09%), Query Frame = 1
Query: 1330 LLKALESRWRENPLIKDLSDILVDFCSEKLKPYVTYLRNQRFQTDTYNKLLNYPEFLNIIKKFENDPDCSMMNLCSFLMLPMQRVLRLKLLMTVVKHHIPKGYPTDGCDEAIEALEKLIKECSDEKMVMEQKEEILLICNRLIIKDKMNVSIGSKPLLKNGALKVISNNKHASKLLGSSLLNRNNKRAQLYLFEDQLIIAKQRKLPLCVSSDDNREVVVDTCQRFNVKFVEISPQKPLSRFNFKLVLSNGMKGSAEYICSVDNPDDLNEWKNAFSVNKSRHEEFDFGEAFVICDYTPTSKKEIGLKKGQILNIIKRIDNERAIASFSGKQGEILLSCVQYVSTPQPNAEILKEIRLSICSRNNNQY 2427
LLKALESRWRENPLIKDLSDILVDFCSEKLKPYVTYLRNQRFQTDTYNKLLNYPEFLNIIKKFENDPDCSMMNLCSFLMLPMQRVLRLKLLMTVVKHHIPKGYPTDGCDEAIEALEKLIKECSDEKMVMEQKEEILLICNRLIIKDKMNVSIGSKPLLKNGALKVISNNKHASKLLGSSLLNRNNKRAQLYLFEDQLIIAKQR +DDNREVVVDTCQRFNVKFVEISPQKPLSRFNFKLVLSNGMKGSAEYICSVDNPDDLNEWKNAFSVNKSRHEEFDFGEAFVICDYTPTSKKEIGLKKGQILNIIKRIDNERAIASFSGKQGEILLSCVQYVSTPQPNAEILKEIRLSICSRNNNQY
Sbjct: 93 LLKALESRWRENPLIKDLSDILVDFCSEKLKPYVTYLRNQRFQTDTYNKLLNYPEFLNIIKKFENDPDCSMMNLCSFLMLPMQRVLRLKLLMTVVKHHIPKGYPTDGCDEAIEALEKLIKECSDEKMVMEQKEEILLICNRLIIKDKMNVSIGSKPLLKNGALKVISNNKHASKLLGSSLLNRNNKRAQLYLFEDQLIIAKQR-------NDDNREVVVDTCQRFNVKFVEISPQKPLSRFNFKLVLSNGMKGSAEYICSVDNPDDLNEWKNAFSVNKSRHEEFDFGEAFVICDYTPTSKKEIGLKKGQILNIIKRIDNERAIASFSGKQGEILLSCVQYVSTPQPNAEILKEIRLSICSRNNNQY 451
BLAST of Rho guanine nucleotide exchange factor vs. Planmine SMEST
Match: SMESG000003902.1 (SMESG000003902.1) HSP 1 Score: 727.243 bits (1876), Expect = 0.000e+0 Identity = 358/366 (97.81%), Postives = 359/366 (98.09%), Query Frame = 1
Query: 1330 LLKALESRWRENPLIKDLSDILVDFCSEKLKPYVTYLRNQRFQTDTYNKLLNYPEFLNIIKKFENDPDCSMMNLCSFLMLPMQRVLRLKLLMTVVKHHIPKGYPTDGCDEAIEALEKLIKECSDEKMVMEQKEEILLICNRLIIKDKMNVSIGSKPLLKNGALKVISNNKHASKLLGSSLLNRNNKRAQLYLFEDQLIIAKQRKLPLCVSSDDNREVVVDTCQRFNVKFVEISPQKPLSRFNFKLVLSNGMKGSAEYICSVDNPDDLNEWKNAFSVNKSRHEEFDFGEAFVICDYTPTSKKEIGLKKGQILNIIKRIDNERAIASFSGKQGEILLSCVQYVSTPQPNAEILKEIRLSICSRNNNQY 2427
LLKALESRWRENPLIKDLSDILVDFCSEKLKPYVTYLRNQRFQTDTYNKLLNYPEFLNIIKKFENDPDCSMMNLCSFLMLPMQRVLRLKLLMTVVKHHIPKGYPTDGCDEAIEALEKLIKECSDEKMVMEQKEEILLICNRLIIKDKMNVSIGSKPLLKNGALKVISNNKHASKLLGSSLLNRNNKRAQLYLFEDQLIIAKQR +DDNREVVVDTCQRFNVKFVEISPQKPLSRFNFKLVLSNGMKGSAEYICSVDNPDDLNEWKNAFSVNKSRHEEFDFGEAFVICDYTPTSKKEIGLKKGQILNIIKRIDNERAIASFSGKQGEILLSCVQYVSTPQPNAEILKEIRLSICSRNNNQY
Sbjct: 84 LLKALESRWRENPLIKDLSDILVDFCSEKLKPYVTYLRNQRFQTDTYNKLLNYPEFLNIIKKFENDPDCSMMNLCSFLMLPMQRVLRLKLLMTVVKHHIPKGYPTDGCDEAIEALEKLIKECSDEKMVMEQKEEILLICNRLIIKDKMNVSIGSKPLLKNGALKVISNNKHASKLLGSSLLNRNNKRAQLYLFEDQLIIAKQR-------NDDNREVVVDTCQRFNVKFVEISPQKPLSRFNFKLVLSNGMKGSAEYICSVDNPDDLNEWKNAFSVNKSRHEEFDFGEAFVICDYTPTSKKEIGLKKGQILNIIKRIDNERAIASFSGKQGEILLSCVQYVSTPQPNAEILKEIRLSICSRNNNQY 442 The following BLAST results are available for this feature:
BLAST of Rho guanine nucleotide exchange factor vs. Ensembl Human
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Human e!99) Total hits: 5
BLAST of Rho guanine nucleotide exchange factor vs. Ensembl Celegans
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99) Total hits: 4
BLAST of Rho guanine nucleotide exchange factor vs. Ensembl Fly
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99) Total hits: 5
BLAST of Rho guanine nucleotide exchange factor vs. Ensembl Zebrafish
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99) Total hits: 5
BLAST of Rho guanine nucleotide exchange factor vs. Ensembl Xenopus
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99) Total hits: 5
BLAST of Rho guanine nucleotide exchange factor vs. Ensembl Mouse
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99) Total hits: 5
BLAST of Rho guanine nucleotide exchange factor vs. UniProt/SwissProt
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt) Total hits: 5
BLAST of Rho guanine nucleotide exchange factor vs. TrEMBL
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL) Total hits: 5
BLAST of Rho guanine nucleotide exchange factor vs. Ensembl Cavefish
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99) Total hits: 5
BLAST of Rho guanine nucleotide exchange factor vs. Ensembl Sea Lamprey
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99) Total hits: 5
BLAST of Rho guanine nucleotide exchange factor vs. Ensembl Yeast
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46) Total hits: 2
BLAST of Rho guanine nucleotide exchange factor vs. Ensembl Nematostella
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46) Total hits: 2
BLAST of Rho guanine nucleotide exchange factor vs. Ensembl Medaka
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99) Total hits: 5
BLAST of Rho guanine nucleotide exchange factor vs. Planmine SMEST
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST) Total hits: 5
Analyses
This transcript is derived from or has results from the following analyses Sequences
The following sequences are available for this feature:
transcript sequence >SMED30011603 ID=SMED30011603|Name=Rho guanine nucleotide exchange factor|organism=Schmidtea mediterranea sexual|type=transcript|length=2999bpback to top protein sequence of SMED30011603-orf-1 >SMED30011603-orf-1 ID=SMED30011603-orf-1|Name=SMED30011603-orf-1|organism=Schmidtea mediterranea sexual|type=polypeptide|length=753bp MDYNIQNSSVEHCCTVERAKQIFDTHNAICGNQSNSFDEHFCSVIQDKKAback to top Annotated Terms
The following terms have been associated with this transcript:
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