HTH CENPB-type domain-containing protein
Overview
Neoblast Clusters
Zeng et. al., 2018▻ Overview▻ Neoblast Population▻ Sub-lethal Irradiated Surviving X1 and X2 Cell Population
Overview
Single cell RNA-seq of pluripotent neoblasts and its early progeniesWe isolated X1 neoblasts cells enriched in high piwi-1 expression (Neoblast Population), and profiled ∼7,614 individual cells via scRNA-seq. Unsupervised analyses uncovered 12 distinct classes from 7,088 high-quality cells. We designated these classes Nb1 to Nb12 and ordered them based on high (Nb1) to low (Nb12) piwi-1 expression levels. We further defined groups of genes that best classified the cells parsed into 12 distinct cell clusters to generate a scaled expression heat map of discriminative gene sets for each cluster. Expression of each cluster’s gene signatures was validated using multiplex fluorescence in situ hybridization (FISH) co-stained with piwi-1 and largely confirmed the cell clusters revealed by scRNA-seq.We also tested sub-lethal irradiation exposure. To profile rare pluripotent stem cells (PSCs) and avoid interference from immediate progenitor cells, we determined a time point after sub-lethal irradiation (7 DPI) with minimal piwi-1+ cells, followed by isolation and single-cell RNA-seq of 1,200 individual cells derived from X1 (Piwi-1 high) and X2 (Piwi-1 low) cell populations (Sub-lethal Irradiated Surviving X1 and X2 Cell Population)Explore this single cell expression dataset with our NB Cluster Shiny App
Neoblast Population
Sub-lethal Irradiated Surviving X1 and X2 Cell Population
Embryonic Expression
Davies et. al., 2017
Hover the mouse over a column in the graph to view average RPKM values per sample. Embryonic Stages: Y: yolk. S2-S8: Stages 2-8. C4: asexual adult. SX: virgin, sexually mature adult. back to top Anatomical Expression
PAGE et. al., 2020SMED30011492 has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGEPAGE Curations: 3
Homology
BLAST of HTH CENPB-type domain-containing protein vs. Ensembl Human
Match: TIGD2 (tigger transposable element derived 2 [Source:HGNC Symbol;Acc:HGNC:18333]) HSP 1 Score: 64.3142 bits (155), Expect = 3.940e-10 Identity = 35/76 (46.05%), Postives = 50/76 (65.79%), Query Frame = 3 Query: 468 KRKEIVLTIKQKNTLVERFEKGESMSKLSEEYGICIQTVRDIVKQKNKLEAFTRDCGGSAGTSKRSSIKTSTFEDL 695 KRK +VLTIK K ++++ E+G S KLS YGI TVRDI K K ++ + ++G SKR S+K+ST+E+L Sbjct: 4 KRKRVVLTIKDKLDIIKKLEEGISFKKLSVVYGIGESTVRDIKKNKERIINYANSSDPTSGVSKRKSMKSSTYEEL 79
BLAST of HTH CENPB-type domain-containing protein vs. Ensembl Human
Match: TIGD2 (tigger transposable element derived 2 [Source:HGNC Symbol;Acc:HGNC:18333]) HSP 1 Score: 64.3142 bits (155), Expect = 3.940e-10 Identity = 35/76 (46.05%), Postives = 50/76 (65.79%), Query Frame = 3 Query: 468 KRKEIVLTIKQKNTLVERFEKGESMSKLSEEYGICIQTVRDIVKQKNKLEAFTRDCGGSAGTSKRSSIKTSTFEDL 695 KRK +VLTIK K ++++ E+G S KLS YGI TVRDI K K ++ + ++G SKR S+K+ST+E+L Sbjct: 4 KRKRVVLTIKDKLDIIKKLEEGISFKKLSVVYGIGESTVRDIKKNKERIINYANSSDPTSGVSKRKSMKSSTYEEL 79
BLAST of HTH CENPB-type domain-containing protein vs. Ensembl Human
Match: JRKL (JRK like [Source:HGNC Symbol;Acc:HGNC:6200]) HSP 1 Score: 55.4546 bits (132), Expect = 2.327e-7 Identity = 31/79 (39.24%), Postives = 48/79 (60.76%), Query Frame = 3 Query: 459 LTKKRKEIVLTIKQKNTLVERFEKGESMSKLSEEYGICIQTVRDIVKQKNKLEAFTRDCGGSAGTSKRSSIKTSTFEDL 695 ++ KRK +VLTIK K ++++ E G S +L+ YGI TVRDI K K K+ + ++ +KR S+K S +E+L Sbjct: 1 MSGKRKRVVLTIKDKLDIIKKLEDGGSSKQLAVIYGIGETTVRDIRKNKEKIITYASSSDSTSLLAKRKSMKPSMYEEL 79
BLAST of HTH CENPB-type domain-containing protein vs. Ensembl Mouse
Match: Tigd2 (tigger transposable element derived 2 [Source:MGI Symbol;Acc:MGI:1915390]) HSP 1 Score: 65.0846 bits (157), Expect = 1.202e-10 Identity = 35/76 (46.05%), Postives = 50/76 (65.79%), Query Frame = 3 Query: 468 KRKEIVLTIKQKNTLVERFEKGESMSKLSEEYGICIQTVRDIVKQKNKLEAFTRDCGGSAGTSKRSSIKTSTFEDL 695 KRK +VLTIK K ++++ E+G S KLS YGI TVRDI K K ++ + ++G SKR S+K+ST+E+L Sbjct: 4 KRKRVVLTIKDKLDIIKKLEEGNSFKKLSVLYGIGESTVRDIKKNKERIINYANSSDPTSGVSKRKSMKSSTYEEL 79
BLAST of HTH CENPB-type domain-containing protein vs. Ensembl Mouse
Match: Jrkl (Jrk-like [Source:MGI Symbol;Acc:MGI:1924782]) HSP 1 Score: 55.0694 bits (131), Expect = 1.638e-7 Identity = 31/79 (39.24%), Postives = 48/79 (60.76%), Query Frame = 3 Query: 459 LTKKRKEIVLTIKQKNTLVERFEKGESMSKLSEEYGICIQTVRDIVKQKNKLEAFTRDCGGSAGTSKRSSIKTSTFEDL 695 ++ KRK +VLTIK K ++++ E G S +L+ YGI TVRDI K K K+ + ++ +KR S+K S +E+L Sbjct: 1 MSGKRKRVVLTIKDKLDIIKKLEDGGSSKQLAVIYGIGETTVRDIRKNKEKIITYASSSDSTSLLAKRKSMKPSMYEEL 79
BLAST of HTH CENPB-type domain-containing protein vs. UniProt/SwissProt
Match: sp|Q0VBL1|TIGD2_MOUSE (Tigger transposable element-derived protein 2 OS=Mus musculus OX=10090 GN=Tigd2 PE=2 SV=1) HSP 1 Score: 65.0846 bits (157), Expect = 8.409e-10 Identity = 35/76 (46.05%), Postives = 50/76 (65.79%), Query Frame = 3 Query: 468 KRKEIVLTIKQKNTLVERFEKGESMSKLSEEYGICIQTVRDIVKQKNKLEAFTRDCGGSAGTSKRSSIKTSTFEDL 695 KRK +VLTIK K ++++ E+G S KLS YGI TVRDI K K ++ + ++G SKR S+K+ST+E+L Sbjct: 4 KRKRVVLTIKDKLDIIKKLEEGNSFKKLSVLYGIGESTVRDIKKNKERIINYANSSDPTSGVSKRKSMKSSTYEEL 79
BLAST of HTH CENPB-type domain-containing protein vs. UniProt/SwissProt
Match: sp|Q4W5G0|TIGD2_HUMAN (Tigger transposable element-derived protein 2 OS=Homo sapiens OX=9606 GN=TIGD2 PE=3 SV=1) HSP 1 Score: 64.3142 bits (155), Expect = 1.892e-9 Identity = 35/76 (46.05%), Postives = 50/76 (65.79%), Query Frame = 3 Query: 468 KRKEIVLTIKQKNTLVERFEKGESMSKLSEEYGICIQTVRDIVKQKNKLEAFTRDCGGSAGTSKRSSIKTSTFEDL 695 KRK +VLTIK K ++++ E+G S KLS YGI TVRDI K K ++ + ++G SKR S+K+ST+E+L Sbjct: 4 KRKRVVLTIKDKLDIIKKLEEGISFKKLSVVYGIGESTVRDIKKNKERIINYANSSDPTSGVSKRKSMKSSTYEEL 79
BLAST of HTH CENPB-type domain-containing protein vs. UniProt/SwissProt
Match: sp|Q9Y4A0|JERKL_HUMAN (Jerky protein homolog-like OS=Homo sapiens OX=9606 GN=JRKL PE=2 SV=2) HSP 1 Score: 55.4546 bits (132), Expect = 1.118e-6 Identity = 31/79 (39.24%), Postives = 48/79 (60.76%), Query Frame = 3 Query: 459 LTKKRKEIVLTIKQKNTLVERFEKGESMSKLSEEYGICIQTVRDIVKQKNKLEAFTRDCGGSAGTSKRSSIKTSTFEDL 695 ++ KRK +VLTIK K ++++ E G S +L+ YGI TVRDI K K K+ + ++ +KR S+K S +E+L Sbjct: 1 MSGKRKRVVLTIKDKLDIIKKLEDGGSSKQLAVIYGIGETTVRDIRKNKEKIITYASSSDSTSLLAKRKSMKPSMYEEL 79
BLAST of HTH CENPB-type domain-containing protein vs. UniProt/SwissProt
Match: sp|B2RRL2|JERKL_MOUSE (Jerky protein homolog-like OS=Mus musculus OX=10090 GN=Jrkl PE=2 SV=1) HSP 1 Score: 55.0694 bits (131), Expect = 1.146e-6 Identity = 31/79 (39.24%), Postives = 48/79 (60.76%), Query Frame = 3 Query: 459 LTKKRKEIVLTIKQKNTLVERFEKGESMSKLSEEYGICIQTVRDIVKQKNKLEAFTRDCGGSAGTSKRSSIKTSTFEDL 695 ++ KRK +VLTIK K ++++ E G S +L+ YGI TVRDI K K K+ + ++ +KR S+K S +E+L Sbjct: 1 MSGKRKRVVLTIKDKLDIIKKLEDGGSSKQLAVIYGIGETTVRDIRKNKEKIITYASSSDSTSLLAKRKSMKPSMYEEL 79
BLAST of HTH CENPB-type domain-containing protein vs. TrEMBL
Match: A0A182QDM1 (HTH CENPB-type domain-containing protein OS=Anopheles farauti OX=69004 PE=4 SV=1) HSP 1 Score: 90.8929 bits (224), Expect = 2.247e-15 Identity = 47/95 (49.47%), Postives = 67/95 (70.53%), Query Frame = 3 Query: 444 MEKERLTKKRKEIVLTIKQKNTLVERFEKGESMSKLSEEYGICIQTVRDIVKQKNKLEAFTRDCGGSAGTSKRSSIKTSTFEDLKDPDIVSLVTE 728 ME ++ KRK+IVLT++QK TL+ R+EKGE+ LS+EY I +QTVRDI+KQK K+ F ++C G +KR S+K ST+E+L D ++S E Sbjct: 42 MEPQQSAGKRKKIVLTLEQKLTLIRRYEKGETAQGLSKEYHIGLQTVRDIIKQKEKILMFIQNCDTYDGPTKRKSMKMSTYEEL-DASMLSWYNE 135
BLAST of HTH CENPB-type domain-containing protein vs. TrEMBL
Match: A0A182N6W4 (Uncharacterized protein OS=Anopheles dirus OX=7168 PE=4 SV=1) HSP 1 Score: 79.337 bits (194), Expect = 9.631e-12 Identity = 41/90 (45.56%), Postives = 61/90 (67.78%), Query Frame = 3 Query: 459 LTKKRKEIVLTIKQKNTLVERFEKGESMSKLSEEYGICIQTVRDIVKQKNKLEAFTRDCGGSAGTSKRSSIKTSTFEDLKDPDIVSLVTE 728 + KRK+IVLT++QK TL+ R EKGE+ L+++Y I +QTVRDI+KQK K+ +F + C G +KR S+K S + +L D ++S E Sbjct: 1 MPAKRKKIVLTLEQKLTLIRRCEKGETTQALAKQYHIGLQTVRDIIKQKAKILSFIQHCDTYDGPTKRKSMKISMYGEL-DASMLSWYNE 89
BLAST of HTH CENPB-type domain-containing protein vs. TrEMBL
Match: A0A4Y2HP36 (Jerky-like OS=Araneus ventricosus OX=182803 GN=JRKL_12 PE=4 SV=1) HSP 1 Score: 73.9442 bits (180), Expect = 6.526e-11 Identity = 37/76 (48.68%), Postives = 52/76 (68.42%), Query Frame = 3 Query: 468 KRKEIVLTIKQKNTLVERFEKGESMSKLSEEYGICIQTVRDIVKQKNKLEAFTRDCGGSAGTSKRSSIKTSTFEDL 695 KRK VL ++QK +++ + GES KL+++Y I +QTVRDI K KL FTRDC + SKR S+KT+T++DL Sbjct: 5 KRKRNVLNVEQKLEILQNLDNGESARKLAKDYQIGVQTVRDIKNNKEKLITFTRDCDDKSVLSKRKSLKTTTYKDL 80
BLAST of HTH CENPB-type domain-containing protein vs. TrEMBL
Match: A0A182VQC7 (HTH CENPB-type domain-containing protein OS=Anopheles minimus OX=112268 PE=4 SV=1) HSP 1 Score: 74.3294 bits (181), Expect = 4.058e-10 Identity = 39/90 (43.33%), Postives = 59/90 (65.56%), Query Frame = 3 Query: 459 LTKKRKEIVLTIKQKNTLVERFEKGESMSKLSEEYGICIQTVRDIVKQKNKLEAFTRDCGGSAGTSKRSSIKTSTFEDLKDPDIVSLVTE 728 + ++RK+ +LT+ QK LVER + GE+ +L++ Y I QT RDI+KQ+ KL F ++C S G KR S+K S+FE+L D ++S E Sbjct: 9 IHRRRKKTMLTLAQKIALVERHDAGETPQELAKSYKIGEQTARDIIKQRAKLWKFVQNCETSEGPVKRKSMKVSSFEEL-DASMLSWYNE 97
BLAST of HTH CENPB-type domain-containing protein vs. TrEMBL
Match: A0A182SYG3 (HTH CENPB-type domain-containing protein OS=Anopheles maculatus OX=74869 PE=4 SV=1) HSP 1 Score: 71.633 bits (174), Expect = 4.361e-10 Identity = 37/90 (41.11%), Postives = 59/90 (65.56%), Query Frame = 3 Query: 459 LTKKRKEIVLTIKQKNTLVERFEKGESMSKLSEEYGICIQTVRDIVKQKNKLEAFTRDCGGSAGTSKRSSIKTSTFEDLKDPDIVSLVTE 728 + ++RK+ +LT+ QK L+ER + GE+ LS+ + I QT RDI+KQ++K+ F ++C S G KR S+K S+FE+L D ++S E Sbjct: 9 ILRRRKKTMLTLAQKIALIERHDLGETPQDLSKSFQIGEQTARDIIKQRDKIWKFVQNCETSEGPVKRKSMKISSFEEL-DASMLSWYNE 97
BLAST of HTH CENPB-type domain-containing protein vs. Planmine SMEST
Match: SMESG000036917.1 (SMESG000036917.1) HSP 1 Score: 102.834 bits (255), Expect = 1.408e-22 Identity = 46/62 (74.19%), Postives = 56/62 (90.32%), Query Frame = 3 Query: 669 IKTSTFEDLKDPDIVSLVTEKEEDESNNTSKEDTSGYVSHEMALNCIETLLDYAEQRGTEYN 854 ++ ++FE ++DPDIVS VT+KEE++SN S+EDTSGYVSHE ALNCIETLLDYAEQRGTEYN Sbjct: 753 LEITSFERMEDPDIVSFVTQKEENDSNTISEEDTSGYVSHETALNCIETLLDYAEQRGTEYN 814
BLAST of HTH CENPB-type domain-containing protein vs. Planmine SMEST
Match: SMESG000036917.1 (SMESG000036917.1) HSP 1 Score: 102.834 bits (255), Expect = 1.475e-22 Identity = 46/62 (74.19%), Postives = 56/62 (90.32%), Query Frame = 3 Query: 669 IKTSTFEDLKDPDIVSLVTEKEEDESNNTSKEDTSGYVSHEMALNCIETLLDYAEQRGTEYN 854 ++ ++FE ++DPDIVS VT+KEE++SN S+EDTSGYVSHE ALNCIETLLDYAEQRGTEYN Sbjct: 731 LEITSFERMEDPDIVSFVTQKEENDSNTISEEDTSGYVSHETALNCIETLLDYAEQRGTEYN 792
BLAST of HTH CENPB-type domain-containing protein vs. Planmine SMEST
Match: SMESG000036917.1 (SMESG000036917.1) HSP 1 Score: 102.834 bits (255), Expect = 1.708e-22 Identity = 46/62 (74.19%), Postives = 56/62 (90.32%), Query Frame = 3 Query: 669 IKTSTFEDLKDPDIVSLVTEKEEDESNNTSKEDTSGYVSHEMALNCIETLLDYAEQRGTEYN 854 ++ ++FE ++DPDIVS VT+KEE++SN S+EDTSGYVSHE ALNCIETLLDYAEQRGTEYN Sbjct: 818 LEITSFERMEDPDIVSFVTQKEENDSNTISEEDTSGYVSHETALNCIETLLDYAEQRGTEYN 879 The following BLAST results are available for this feature:
BLAST of HTH CENPB-type domain-containing protein vs. Ensembl Human
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Human e!99) Total hits: 3
BLAST of HTH CENPB-type domain-containing protein vs. Ensembl Celegans
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99) Total hits: 0
BLAST of HTH CENPB-type domain-containing protein vs. Ensembl Fly
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99) Total hits: 0
BLAST of HTH CENPB-type domain-containing protein vs. Ensembl Zebrafish
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99) Total hits: 0
BLAST of HTH CENPB-type domain-containing protein vs. Ensembl Xenopus
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99) Total hits: 0
BLAST of HTH CENPB-type domain-containing protein vs. Ensembl Mouse
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99) Total hits: 2
BLAST of HTH CENPB-type domain-containing protein vs. UniProt/SwissProt
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt) Total hits: 4
BLAST of HTH CENPB-type domain-containing protein vs. TrEMBL
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL) Total hits: 5
BLAST of HTH CENPB-type domain-containing protein vs. Ensembl Cavefish
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99) Total hits: 0
BLAST of HTH CENPB-type domain-containing protein vs. Ensembl Sea Lamprey
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99) Total hits: 0
BLAST of HTH CENPB-type domain-containing protein vs. Ensembl Yeast
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46) Total hits: 0
BLAST of HTH CENPB-type domain-containing protein vs. Ensembl Nematostella
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46) Total hits: 0
BLAST of HTH CENPB-type domain-containing protein vs. Ensembl Medaka
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99) Total hits: 0
BLAST of HTH CENPB-type domain-containing protein vs. Planmine SMEST
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST) Total hits: 3
Analyses
This transcript is derived from or has results from the following analyses Sequences
The following sequences are available for this feature:
transcript sequence >SMED30011492 ID=SMED30011492|Name=HTH CENPB-type domain-containing protein|organism=Schmidtea mediterranea sexual|type=transcript|length=1768bpback to top protein sequence of SMED30011492-orf-1 >SMED30011492-orf-1 ID=SMED30011492-orf-1|Name=SMED30011492-orf-1|organism=Schmidtea mediterranea sexual|type=polypeptide|length=170bp MEKERLTKKRKEIVLTIKQKNTLVERFEKGESMSKLSEEYGICIQTVRDIback to top Annotated Terms
The following terms have been associated with this transcript:
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