Phosphodiesterase

Overview
NamePhosphodiesterase
Smed IDSMED30011414
Length (bp)1511
Neoblast Clusters

Zeng et. al., 2018



▻ Overview

▻ Neoblast Population

▻ Sub-lethal Irradiated Surviving X1 and X2 Cell Population

 

 

Overview

 

Single cell RNA-seq of pluripotent neoblasts and its early progenies


We isolated X1 neoblasts cells enriched in high piwi-1 expression (Neoblast Population), and profiled ∼7,614 individual cells via scRNA-seq. Unsupervised analyses uncovered 12 distinct classes from 7,088 high-quality cells. We designated these classes Nb1 to Nb12 and ordered them based on high (Nb1) to low (Nb12) piwi-1 expression levels. We further defined groups of genes that best classified the cells parsed into 12 distinct cell clusters to generate a scaled expression heat map of discriminative gene sets for each cluster. Expression of each cluster’s gene signatures was validated using multiplex fluorescence in situ hybridization (FISH) co-stained with piwi-1 and largely confirmed the cell clusters revealed by scRNA-seq.

We also tested sub-lethal irradiation exposure. To profile rare pluripotent stem cells (PSCs) and avoid interference from immediate progenitor cells, we determined a time point after sub-lethal irradiation (7 DPI) with minimal piwi-1+ cells, followed by isolation and single-cell RNA-seq of 1,200 individual cells derived from X1 (Piwi-1 high) and X2 (Piwi-1 low) cell populations (Sub-lethal Irradiated Surviving X1 and X2 Cell Population)



Explore this single cell expression dataset with our NB Cluster Shiny App



 

Neoblast Population

 

t-SNE plot shows two-dimensional representation of global gene expression relationships among all neoblasts (n = 7,088 after filter). Cluster identity was assigned based on the top 10 marker genes of each cluster (Table S2), followed by inspection of RNA in situ hybridization patterns. Neoblast groups, Nb.


Expression of Phosphodiesterase (SMED30011414) t-SNE clustered cells

Violin plots show distribution of expression levels for Phosphodiesterase (SMED30011414) in cells (dots) of each of the 12 neoblast clusters.

 

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Sub-lethal Irradiated Surviving X1 and X2 Cell Population

 

t-SNE plot of surviving X1 and X2 cells (n = 1,039 after QC filter) after sub-lethal irradiation. Colors indicate unbiased cell classification via graph-based clustering. SL, sub-lethal irradiated cell groups.

Expression of Phosphodiesterase (SMED30011414) in the t-SNE clustered sub-lethally irradiated X1 and X2 cells.

Violin plots show distribution of expression levels for Phosphodiesterase (SMED30011414) in cells (dots) of each of the 10 clusters of sub-leathally irradiated X1 and X2 cells.

 

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Embryonic Expression

Davies et. al., 2017

Hover the mouse over a column in the graph to view average RPKM values per sample.
Sort Descending | Sort Ascending | Only Non-Zero Values | Tile/Chart | Reset

Embryonic Stages: Y: yolk. S2-S8: Stages 2-8. C4: asexual adult. SX: virgin, sexually mature adult.
For further information about sample preparation and analysis for the single animal RNA-Seq experiment, please refer to the Materials and Methods

 

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Anatomical Expression

PAGE et. al., 2020



SMED30011414

has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGE



PAGE Curations: 5

  
Expressed InReference TranscriptGene ModelsPublished TranscriptTranscriptomePublicationSpecimenLifecycleEvidence
head regionSMED30011414SMESG000044267.1 SmedASXL_007498SmedAsxl_ww_GCZZ01PMID:27034770
Currie et al., 2016		whole organism asexual adult RNA-sequencing evidence
nervous systemSMED30011414SMESG000044267.1 dd_Smed_v4_26758_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018		FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
cephalic gangliaSMED30011414SMESG000044267.1 dd_Smed_v4_26758_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018		FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
cilated neuronSMED30011414SMESG000044267.1 dd_Smed_v4_26758_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018		FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
head regionSMED30011414SMESG000044267.1 dd_Smed_v6_26758_0_1dd_Smed_v6PMID:28171748
Stückemann et al., 2017		whole organism asexual adult RNA-sequencing evidence
Note: Hover over icons to view figure legend
Homology
[Close]
BLAST of Phosphodiesterase vs. Ensembl Human
Match: PDE1C (phosphodiesterase 1C [Source:HGNC Symbol;Acc:HGNC:8776])

HSP 1 Score: 408.297 bits (1048), Expect = 5.519e-136
Identity = 194/421 (46.08%), Postives = 291/421 (69.12%), Query Frame = 3 
Query:   87 RTLSENLKLCLSQLENGEINRIVLINNLQDTSQFLDKAFLNSLSK---DEDIFSETDSE-LPENVQEWISSTFTKRQKV---SPPPRQRLRSLINAVRVGMYFDRAFRKVSLPGSISAPPNAMIYLKQHINNWTFDIFHFNNLANNHSLKIMGYELLHSNQLISRFSIDINVLEAFLDKLEEGYSLHQNPYHNLIHAADVAHTCFLIVSKSRLFNWLSDLELFSILISALIHDFEHTGTSNNYHVNLNSNLALIYNDRSVLENHHLSAAFRLMKDD-RYNIVQSLNANEYRELRNMVIEMVLATDMSAHFNQVQVMKEGVLLPESLRKINILSYVLHSADISHPCKPWEMHHQWTNMVVEEFFRQGDNEKEFGLTCSPLCDRDSTLIPESQIGFINFIVEPCFLVLGDIQKAISILCPDET 1325
            +  S+ L+  + QLE GE + + L  NL+  +  L+  +++   +    ED  S+  S+ +P  V++W++STFT++  +       + R +S+++AV+ G++ +R +R+ S    +S PP A+I   + ++ W+FD+F  N  + +H+LK + YELL    LISRF I I+ L +F++ LE GYS H+NPYHNL+HAADV  T   ++ K+ + NWL++LE+F+I+ SA IHD+EHTGT+NN+H+   S+ A++YNDRSVLENHHLSAA+RL++DD   NI+ +L+ +++RE R +VIEMV+ATDMS HF Q++ MK  +  PE++ K   LS +LH+ADISHP K W++HH+WT  ++EEFFRQGD E E GL  SPLCDR ST++ +SQ+GFI+FIVEP F VL D+ + I     DET
Sbjct:   38 KKTSQRLRSLVKQLERGEASVVDLKKNLEYAATVLESVYIDETRRLLDTEDELSDIQSDAVPSEVRDWLASTFTRQMGMMLRRSDEKPRFKSIVHAVQAGIFVERMYRRTSNMVGLSYPP-AVIEALKDVDKWSFDVFSLNEASGDHALKFIFYELLTRYDLISRFKIPISALVSFVEALEVGYSKHKNPYHNLMHAADVTQTVHYLLYKTGVANWLTELEIFAIIFSAAIHDYEHTGTTNNFHIQTRSDPAILYNDRSVLENHHLSAAYRLLQDDEEMNILINLSKDDWREFRTLVIEMVMATDMSCHFQQIKAMKTALQQPEAIEKPKALSLMLHTADISHPAKAWDLHHRWTMSLLEEFFRQGDREAELGLPFSPLCDRKSTMVAQSQVGFIDFIVEPTFTVLTDMTEKIVSPLIDET 457
[Close]
BLAST of Phosphodiesterase vs. Ensembl Human
Match: PDE1C (phosphodiesterase 1C [Source:HGNC Symbol;Acc:HGNC:8776])

HSP 1 Score: 408.297 bits (1048), Expect = 5.519e-136
Identity = 194/421 (46.08%), Postives = 291/421 (69.12%), Query Frame = 3 
Query:   87 RTLSENLKLCLSQLENGEINRIVLINNLQDTSQFLDKAFLNSLSK---DEDIFSETDSE-LPENVQEWISSTFTKRQKV---SPPPRQRLRSLINAVRVGMYFDRAFRKVSLPGSISAPPNAMIYLKQHINNWTFDIFHFNNLANNHSLKIMGYELLHSNQLISRFSIDINVLEAFLDKLEEGYSLHQNPYHNLIHAADVAHTCFLIVSKSRLFNWLSDLELFSILISALIHDFEHTGTSNNYHVNLNSNLALIYNDRSVLENHHLSAAFRLMKDD-RYNIVQSLNANEYRELRNMVIEMVLATDMSAHFNQVQVMKEGVLLPESLRKINILSYVLHSADISHPCKPWEMHHQWTNMVVEEFFRQGDNEKEFGLTCSPLCDRDSTLIPESQIGFINFIVEPCFLVLGDIQKAISILCPDET 1325
            +  S+ L+  + QLE GE + + L  NL+  +  L+  +++   +    ED  S+  S+ +P  V++W++STFT++  +       + R +S+++AV+ G++ +R +R+ S    +S PP A+I   + ++ W+FD+F  N  + +H+LK + YELL    LISRF I I+ L +F++ LE GYS H+NPYHNL+HAADV  T   ++ K+ + NWL++LE+F+I+ SA IHD+EHTGT+NN+H+   S+ A++YNDRSVLENHHLSAA+RL++DD   NI+ +L+ +++RE R +VIEMV+ATDMS HF Q++ MK  +  PE++ K   LS +LH+ADISHP K W++HH+WT  ++EEFFRQGD E E GL  SPLCDR ST++ +SQ+GFI+FIVEP F VL D+ + I     DET
Sbjct:   38 KKTSQRLRSLVKQLERGEASVVDLKKNLEYAATVLESVYIDETRRLLDTEDELSDIQSDAVPSEVRDWLASTFTRQMGMMLRRSDEKPRFKSIVHAVQAGIFVERMYRRTSNMVGLSYPP-AVIEALKDVDKWSFDVFSLNEASGDHALKFIFYELLTRYDLISRFKIPISALVSFVEALEVGYSKHKNPYHNLMHAADVTQTVHYLLYKTGVANWLTELEIFAIIFSAAIHDYEHTGTTNNFHIQTRSDPAILYNDRSVLENHHLSAAYRLLQDDEEMNILINLSKDDWREFRTLVIEMVMATDMSCHFQQIKAMKTALQQPEAIEKPKALSLMLHTADISHPAKAWDLHHRWTMSLLEEFFRQGDREAELGLPFSPLCDRKSTMVAQSQVGFIDFIVEPTFTVLTDMTEKIVSPLIDET 457
[Close]
BLAST of Phosphodiesterase vs. Ensembl Human
Match: PDE1C (phosphodiesterase 1C [Source:HGNC Symbol;Acc:HGNC:8776])

HSP 1 Score: 407.142 bits (1045), Expect = 1.277e-134
Identity = 194/421 (46.08%), Postives = 291/421 (69.12%), Query Frame = 3 
Query:   87 RTLSENLKLCLSQLENGEINRIVLINNLQDTSQFLDKAFLNSLSK---DEDIFSETDSE-LPENVQEWISSTFTKRQKV---SPPPRQRLRSLINAVRVGMYFDRAFRKVSLPGSISAPPNAMIYLKQHINNWTFDIFHFNNLANNHSLKIMGYELLHSNQLISRFSIDINVLEAFLDKLEEGYSLHQNPYHNLIHAADVAHTCFLIVSKSRLFNWLSDLELFSILISALIHDFEHTGTSNNYHVNLNSNLALIYNDRSVLENHHLSAAFRLMKDD-RYNIVQSLNANEYRELRNMVIEMVLATDMSAHFNQVQVMKEGVLLPESLRKINILSYVLHSADISHPCKPWEMHHQWTNMVVEEFFRQGDNEKEFGLTCSPLCDRDSTLIPESQIGFINFIVEPCFLVLGDIQKAISILCPDET 1325
            +  S+ L+  + QLE GE + + L  NL+  +  L+  +++   +    ED  S+  S+ +P  V++W++STFT++  +       + R +S+++AV+ G++ +R +R+ S    +S PP A+I   + ++ W+FD+F  N  + +H+LK + YELL    LISRF I I+ L +F++ LE GYS H+NPYHNL+HAADV  T   ++ K+ + NWL++LE+F+I+ SA IHD+EHTGT+NN+H+   S+ A++YNDRSVLENHHLSAA+RL++DD   NI+ +L+ +++RE R +VIEMV+ATDMS HF Q++ MK  +  PE++ K   LS +LH+ADISHP K W++HH+WT  ++EEFFRQGD E E GL  SPLCDR ST++ +SQ+GFI+FIVEP F VL D+ + I     DET
Sbjct:   38 KKTSQRLRSLVKQLERGEASVVDLKKNLEYAATVLESVYIDETRRLLDTEDELSDIQSDAVPSEVRDWLASTFTRQMGMMLRRSDEKPRFKSIVHAVQAGIFVERMYRRTSNMVGLSYPP-AVIEALKDVDKWSFDVFSLNEASGDHALKFIFYELLTRYDLISRFKIPISALVSFVEALEVGYSKHKNPYHNLMHAADVTQTVHYLLYKTGVANWLTELEIFAIIFSAAIHDYEHTGTTNNFHIQTRSDPAILYNDRSVLENHHLSAAYRLLQDDEEMNILINLSKDDWREFRTLVIEMVMATDMSCHFQQIKAMKTALQQPEAIEKPKALSLMLHTADISHPAKAWDLHHRWTMSLLEEFFRQGDREAELGLPFSPLCDRKSTMVAQSQVGFIDFIVEPTFTVLTDMTEKIVSPLIDET 457
[Close]
BLAST of Phosphodiesterase vs. Ensembl Human
Match: PDE1C (phosphodiesterase 1C [Source:HGNC Symbol;Acc:HGNC:8776])

HSP 1 Score: 407.142 bits (1045), Expect = 1.277e-134
Identity = 194/421 (46.08%), Postives = 291/421 (69.12%), Query Frame = 3 
Query:   87 RTLSENLKLCLSQLENGEINRIVLINNLQDTSQFLDKAFLNSLSK---DEDIFSETDSE-LPENVQEWISSTFTKRQKV---SPPPRQRLRSLINAVRVGMYFDRAFRKVSLPGSISAPPNAMIYLKQHINNWTFDIFHFNNLANNHSLKIMGYELLHSNQLISRFSIDINVLEAFLDKLEEGYSLHQNPYHNLIHAADVAHTCFLIVSKSRLFNWLSDLELFSILISALIHDFEHTGTSNNYHVNLNSNLALIYNDRSVLENHHLSAAFRLMKDD-RYNIVQSLNANEYRELRNMVIEMVLATDMSAHFNQVQVMKEGVLLPESLRKINILSYVLHSADISHPCKPWEMHHQWTNMVVEEFFRQGDNEKEFGLTCSPLCDRDSTLIPESQIGFINFIVEPCFLVLGDIQKAISILCPDET 1325
            +  S+ L+  + QLE GE + + L  NL+  +  L+  +++   +    ED  S+  S+ +P  V++W++STFT++  +       + R +S+++AV+ G++ +R +R+ S    +S PP A+I   + ++ W+FD+F  N  + +H+LK + YELL    LISRF I I+ L +F++ LE GYS H+NPYHNL+HAADV  T   ++ K+ + NWL++LE+F+I+ SA IHD+EHTGT+NN+H+   S+ A++YNDRSVLENHHLSAA+RL++DD   NI+ +L+ +++RE R +VIEMV+ATDMS HF Q++ MK  +  PE++ K   LS +LH+ADISHP K W++HH+WT  ++EEFFRQGD E E GL  SPLCDR ST++ +SQ+GFI+FIVEP F VL D+ + I     DET
Sbjct:   38 KKTSQRLRSLVKQLERGEASVVDLKKNLEYAATVLESVYIDETRRLLDTEDELSDIQSDAVPSEVRDWLASTFTRQMGMMLRRSDEKPRFKSIVHAVQAGIFVERMYRRTSNMVGLSYPP-AVIEALKDVDKWSFDVFSLNEASGDHALKFIFYELLTRYDLISRFKIPISALVSFVEALEVGYSKHKNPYHNLMHAADVTQTVHYLLYKTGVANWLTELEIFAIIFSAAIHDYEHTGTTNNFHIQTRSDPAILYNDRSVLENHHLSAAYRLLQDDEEMNILINLSKDDWREFRTLVIEMVMATDMSCHFQQIKAMKTALQQPEAIEKPKALSLMLHTADISHPAKAWDLHHRWTMSLLEEFFRQGDREAELGLPFSPLCDRKSTMVAQSQVGFIDFIVEPTFTVLTDMTEKIVSPLIDET 457
[Close]
BLAST of Phosphodiesterase vs. Ensembl Human
Match: PDE1C (phosphodiesterase 1C [Source:HGNC Symbol;Acc:HGNC:8776])

HSP 1 Score: 404.06 bits (1037), Expect = 1.078e-132
Identity = 193/415 (46.51%), Postives = 288/415 (69.40%), Query Frame = 3 
Query:  105 LKLCLSQLENGEINRIVLINNLQDTSQFLDKAFLNSLSK---DEDIFSETDSE-LPENVQEWISSTFTKRQKV---SPPPRQRLRSLINAVRVGMYFDRAFRKVSLPGSISAPPNAMIYLKQHINNWTFDIFHFNNLANNHSLKIMGYELLHSNQLISRFSIDINVLEAFLDKLEEGYSLHQNPYHNLIHAADVAHTCFLIVSKSRLFNWLSDLELFSILISALIHDFEHTGTSNNYHVNLNSNLALIYNDRSVLENHHLSAAFRLMKDD-RYNIVQSLNANEYRELRNMVIEMVLATDMSAHFNQVQVMKEGVLLPESLRKINILSYVLHSADISHPCKPWEMHHQWTNMVVEEFFRQGDNEKEFGLTCSPLCDRDSTLIPESQIGFINFIVEPCFLVLGDIQKAISILCPDET 1325
            L+  + QLE GE + + L  NL+  +  L+  +++   +    ED  S+  S+ +P  V++W++STFT++  +       + R +S+++AV+ G++ +R +R+ S    +S PP A+I   + ++ W+FD+F  N  + +H+LK + YELL    LISRF I I+ L +F++ LE GYS H+NPYHNL+HAADV  T   ++ K+ + NWL++LE+F+I+ SA IHD+EHTGT+NN+H+   S+ A++YNDRSVLENHHLSAA+RL++DD   NI+ +L+ +++RE R +VIEMV+ATDMS HF Q++ MK  +  PE++ K   LS +LH+ADISHP K W++HH+WT  ++EEFFRQGD E E GL  SPLCDR ST++ +SQ+GFI+FIVEP F VL D+ + I     DET
Sbjct:  104 LRSLVKQLERGEASVVDLKKNLEYAATVLESVYIDETRRLLDTEDELSDIQSDAVPSEVRDWLASTFTRQMGMMLRRSDEKPRFKSIVHAVQAGIFVERMYRRTSNMVGLSYPP-AVIEALKDVDKWSFDVFSLNEASGDHALKFIFYELLTRYDLISRFKIPISALVSFVEALEVGYSKHKNPYHNLMHAADVTQTVHYLLYKTGVANWLTELEIFAIIFSAAIHDYEHTGTTNNFHIQTRSDPAILYNDRSVLENHHLSAAYRLLQDDEEMNILINLSKDDWREFRTLVIEMVMATDMSCHFQQIKAMKTALQQPEAIEKPKALSLMLHTADISHPAKAWDLHHRWTMSLLEEFFRQGDREAELGLPFSPLCDRKSTMVAQSQVGFIDFIVEPTFTVLTDMTEKIVSPLIDET 517
[Close]
BLAST of Phosphodiesterase vs. Ensembl Celegans
Match: pde-1 (Probable 3',5'-cyclic phosphodiesterase pde-1 [Source:UniProtKB/Swiss-Prot;Acc:O18696])

HSP 1 Score: 379.407 bits (973), Expect = 1.629e-126
Identity = 194/484 (40.08%), Postives = 289/484 (59.71%), Query Frame = 3 
Query:   87 RTLSENLKLCLSQLENGEINRIVLINNLQDTSQFLDKAFLNSLSK----DEDIFSETDSELPENVQEWISSTFTKRQKVSPPPRQRLRSLINAVRVGMYFDRAFRKVSLPGSISAP-PNAMIYLKQHINNWTFDIFHFNNLANNHSLKIMGYELLHSNQLISRFSIDINVLEAFLDKLEEGYSLHQNPYHNLIHAADVAHTCFLIVSKSRLFNWLSDLELFSILISALIHDFEHTGTSNNYHVNLNSNLALIYNDRSVLENHHLSAAFRLMKDDRYNIVQSLNANEYRELRNMVIEMVLATDMSAHFNQVQVMKEGVLLPESLRKINILSYVLHSADISHPCKPWEMHHQWTNMVVEEFFRQGDNEKEFGLTCSPLCDRDSTLIPESQIGFINFIVEPCFLVLGDI----QKAISILCPDETLL------SDDPSENSTVN-----------------------GEKQIQTPWMDNLGNNKVKW 1424
            R  S  L+  L QL +G++    L  N++  +  L+ A+++   +    D+D+   T   +P+ V+EW+++TFT++       + + +S+ NA+R G++F++ FRK  +   +  P P  +  L + +  W+F  F  N ++  H+LK +G+EL +    + RF + +  LE +L  LE GYS H NPYHN++HAADV  +   ++S++ L N L DLEL ++L  ALIHD+EHTG +NN+H+   S  A++YNDRSVLENHH+S+ FRLMK+D  NI+  L  +EY+ELRNMVIE+VLATDMS HF Q++ MK  + LPE + K   L  ++H+ DISHP KPW +H +WT  V+EEFFRQGD E   GL  SPLCDR +  + +SQIGFI+FIVEP  +V G++     + +  L P ++L        DD S ++ ++                       G+  I TPWM  L  NK  W
Sbjct:   16 RKHSCRLRYILHQLNSGQLPLEDLKRNIEYAALVLETAYMDETRRICDEDDDLAEVTPETVPDEVREWLAATFTRQNAGKKRDKPKFKSVANAIRTGIFFEKLFRKQQV---VQCPIPPEIAELMKEVCTWSFSPFQLNEVSEGHALKYVGFELFNRYGFMDRFKVPLTALENYLSALEVGYSKHNNPYHNVVHAADVTQSSHFMLSQTGLANSLGDLELLAVLFGALIHDYEHTGHTNNFHIQSQSQFAMLYNDRSVLENHHVSSCFRLMKEDDKNILTHLTRDEYKELRNMVIEIVLATDMSTHFMQIKTMKSMLSLPEGIDKNKALCLIVHACDISHPAKPWNLHERWTEGVLEEFFRQGDLEASMGLPYSPLCDRHTVHVADSQIGFIDFIVEPTMVVCGELLVKMVEPLVSLPPTDSLFPPSVDGGDDKSPSNALSPLPDLRNSSTSPSSIRRIPLNYAGKLDIPTPWMKFLHENKAHW 496
[Close]
BLAST of Phosphodiesterase vs. Ensembl Celegans
Match: pde-1 (Probable 3',5'-cyclic phosphodiesterase pde-1 [Source:UniProtKB/Swiss-Prot;Acc:O18696])

HSP 1 Score: 381.719 bits (979), Expect = 9.700e-126
Identity = 193/480 (40.21%), Postives = 288/480 (60.00%), Query Frame = 3 
Query:   99 ENLKLCLSQLENGEINRIVLINNLQDTSQFLDKAFLNSLSK----DEDIFSETDSELPENVQEWISSTFTKRQKVSPPPRQRLRSLINAVRVGMYFDRAFRKVSLPGSISAP-PNAMIYLKQHINNWTFDIFHFNNLANNHSLKIMGYELLHSNQLISRFSIDINVLEAFLDKLEEGYSLHQNPYHNLIHAADVAHTCFLIVSKSRLFNWLSDLELFSILISALIHDFEHTGTSNNYHVNLNSNLALIYNDRSVLENHHLSAAFRLMKDDRYNIVQSLNANEYRELRNMVIEMVLATDMSAHFNQVQVMKEGVLLPESLRKINILSYVLHSADISHPCKPWEMHHQWTNMVVEEFFRQGDNEKEFGLTCSPLCDRDSTLIPESQIGFINFIVEPCFLVLGDI----QKAISILCPDETLL------SDDPSENSTVN-----------------------GEKQIQTPWMDNLGNNKVKW 1424
            E L+  L QL +G++    L  N++  +  L+ A+++   +    D+D+   T   +P+ V+EW+++TFT++       + + +S+ NA+R G++F++ FRK  +   +  P P  +  L + +  W+F  F  N ++  H+LK +G+EL +    + RF + +  LE +L  LE GYS H NPYHN++HAADV  +   ++S++ L N L DLEL ++L  ALIHD+EHTG +NN+H+   S  A++YNDRSVLENHH+S+ FRLMK+D  NI+  L  +EY+ELRNMVIE+VLATDMS HF Q++ MK  + LPE + K   L  ++H+ DISHP KPW +H +WT  V+EEFFRQGD E   GL  SPLCDR +  + +SQIGFI+FIVEP  +V G++     + +  L P ++L        DD S ++ ++                       G+  I TPWM  L  NK  W
Sbjct:  151 EKLRYILHQLNSGQLPLEDLKRNIEYAALVLETAYMDETRRICDEDDDLAEVTPETVPDEVREWLAATFTRQNAGKKRDKPKFKSVANAIRTGIFFEKLFRKQQV---VQCPIPPEIAELMKEVCTWSFSPFQLNEVSEGHALKYVGFELFNRYGFMDRFKVPLTALENYLSALEVGYSKHNNPYHNVVHAADVTQSSHFMLSQTGLANSLGDLELLAVLFGALIHDYEHTGHTNNFHIQSQSQFAMLYNDRSVLENHHVSSCFRLMKEDDKNILTHLTRDEYKELRNMVIEIVLATDMSTHFMQIKTMKSMLSLPEGIDKNKALCLIVHACDISHPAKPWNLHERWTEGVLEEFFRQGDLEASMGLPYSPLCDRHTVHVADSQIGFIDFIVEPTMVVCGELLVKMVEPLVSLPPTDSLFPPSVDGGDDKSPSNALSPLPDLRNSSTSPSSIRRIPLNYAGKLDIPTPWMKFLHENKAHW 627
[Close]
BLAST of Phosphodiesterase vs. Ensembl Celegans
Match: pde-4 (Probable 3',5'-cyclic phosphodiesterase pde-4 [Source:UniProtKB/Swiss-Prot;Acc:Q22000])

HSP 1 Score: 232.646 bits (592), Expect = 1.034e-69
Identity = 148/459 (32.24%), Postives = 233/459 (50.76%), Query Frame = 3 
Query:   75 VQLARTLSENLKLCLSQLENGEINRIVLINNLQDTSQFLDKAFLNSLSKDEDIFSETDSELPENVQEWISSTFTKRQKVSPP-----PRQ----------RLRSLINAVRVGMYFDRAFRKVSLPGSISAPPNAMIYLK-------QHINNWTFDIFHFNNLANNHSLKIMGYELLHSNQLISRFSIDINVLEAFLDKLEEGYSLHQNPYHNLIHAADVAHTCFLIVSKSRLFNWLSDLELFSILISALIHDFEHTGTSNNYHVNLNSNLALIYNDRSVLENHHLSAAFRLMKDDRYNIVQSLNANEYRELRNMVIEMVLATDMSAHFN---QVQVMKEG--------VLLPESLRKINILSYVLHSADISHPCKPWEMHHQWTNMVVEEFFRQGDNEKEFGLTCSPLCDRDSTLIPESQIGFINFIVEPCFLVLGDIQKAISILCPDETLLSDDPSEN 1352
            V  A    E L  CL QLE  + +R V        S+     F   L+K+   F+E+ S+    V +++ +T+  +++  P      P +           L  L  A    M      RK+  P      P   +          Q +++W  D+F  + L+ NHSL ++ + LL    L   F I  + L  +L  LE  Y    N YHN IHAADVA +  +++    L    +DLE+ + + +  +HD +H G +N Y +N N+ LA++YND SVLE HHL+ AF+L++D   + + +L+  +  + R +VI+MVLATDMS H +    ++ M E         ++L +   KI +L  ++H AD+S+P KP E++ QW   ++EE++RQGD EKE GL  SP+CDR +  I +SQ+GFI++IV P +    D      ++ PD   + D   EN
Sbjct:   83 VHCAHDTLEELDWCLDQLETIQTHRSV--------SEMASSKFRKMLNKELSHFAES-SKSGTQVSKFLITTYMDKEEDEPSIEIEVPTEVQGPSTSGPMTLSILKKAQTAAMNKISGVRKLRAPSHDGHVPEYGVNCAREIAVHMQRLDDWGPDVFKIDELSKNHSLTVVTFSLLRQRNLFKTFEIHQSTLVTYLLNLEHHY--RNNHYHNFIHAADVAQSMHVLLMSPVLTEVFTDLEVLAAIFAGAVHDVDHPGFTNQYLINSNNELAIMYNDESVLEQHHLAVAFKLLQDSNCDFLANLSRKQRLQFRKIVIDMVLATDMSKHMSLLADLKTMVEAKKVAGNNVIVLDKYNDKIQVLQSMIHLADLSNPTKPIELYQQWNQRIMEEYWRQGDKEKELGLEISPMCDRGNVTIEKSQVGFIDYIVHPLYETWAD------LVYPDAQNILDQLEEN 524
[Close]
BLAST of Phosphodiesterase vs. Ensembl Celegans
Match: pde-4 (Probable 3',5'-cyclic phosphodiesterase pde-4 [Source:UniProtKB/Swiss-Prot;Acc:Q22000])

HSP 1 Score: 232.646 bits (592), Expect = 3.519e-69
Identity = 148/459 (32.24%), Postives = 233/459 (50.76%), Query Frame = 3 
Query:   75 VQLARTLSENLKLCLSQLENGEINRIVLINNLQDTSQFLDKAFLNSLSKDEDIFSETDSELPENVQEWISSTFTKRQKVSPP-----PRQ----------RLRSLINAVRVGMYFDRAFRKVSLPGSISAPPNAMIYLK-------QHINNWTFDIFHFNNLANNHSLKIMGYELLHSNQLISRFSIDINVLEAFLDKLEEGYSLHQNPYHNLIHAADVAHTCFLIVSKSRLFNWLSDLELFSILISALIHDFEHTGTSNNYHVNLNSNLALIYNDRSVLENHHLSAAFRLMKDDRYNIVQSLNANEYRELRNMVIEMVLATDMSAHFN---QVQVMKEG--------VLLPESLRKINILSYVLHSADISHPCKPWEMHHQWTNMVVEEFFRQGDNEKEFGLTCSPLCDRDSTLIPESQIGFINFIVEPCFLVLGDIQKAISILCPDETLLSDDPSEN 1352
            V  A    E L  CL QLE  + +R V        S+     F   L+K+   F+E+ S+    V +++ +T+  +++  P      P +           L  L  A    M      RK+  P      P   +          Q +++W  D+F  + L+ NHSL ++ + LL    L   F I  + L  +L  LE  Y    N YHN IHAADVA +  +++    L    +DLE+ + + +  +HD +H G +N Y +N N+ LA++YND SVLE HHL+ AF+L++D   + + +L+  +  + R +VI+MVLATDMS H +    ++ M E         ++L +   KI +L  ++H AD+S+P KP E++ QW   ++EE++RQGD EKE GL  SP+CDR +  I +SQ+GFI++IV P +    D      ++ PD   + D   EN
Sbjct:  133 VHCAHDTLEELDWCLDQLETIQTHRSV--------SEMASSKFRKMLNKELSHFAES-SKSGTQVSKFLITTYMDKEEDEPSIEIEVPTEVQGPSTSGPMTLSILKKAQTAAMNKISGVRKLRAPSHDGHVPEYGVNCAREIAVHMQRLDDWGPDVFKIDELSKNHSLTVVTFSLLRQRNLFKTFEIHQSTLVTYLLNLEHHY--RNNHYHNFIHAADVAQSMHVLLMSPVLTEVFTDLEVLAAIFAGAVHDVDHPGFTNQYLINSNNELAIMYNDESVLEQHHLAVAFKLLQDSNCDFLANLSRKQRLQFRKIVIDMVLATDMSKHMSLLADLKTMVEAKKVAGNNVIVLDKYNDKIQVLQSMIHLADLSNPTKPIELYQQWNQRIMEEYWRQGDKEKELGLEISPMCDRGNVTIEKSQVGFIDYIVHPLYETWAD------LVYPDAQNILDQLEEN 574
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BLAST of Phosphodiesterase vs. Ensembl Celegans
Match: pde-4 (Probable 3',5'-cyclic phosphodiesterase pde-4 [Source:UniProtKB/Swiss-Prot;Acc:Q22000])

HSP 1 Score: 232.646 bits (592), Expect = 5.094e-69
Identity = 148/459 (32.24%), Postives = 233/459 (50.76%), Query Frame = 3 
Query:   75 VQLARTLSENLKLCLSQLENGEINRIVLINNLQDTSQFLDKAFLNSLSKDEDIFSETDSELPENVQEWISSTFTKRQKVSPP-----PRQ----------RLRSLINAVRVGMYFDRAFRKVSLPGSISAPPNAMIYLK-------QHINNWTFDIFHFNNLANNHSLKIMGYELLHSNQLISRFSIDINVLEAFLDKLEEGYSLHQNPYHNLIHAADVAHTCFLIVSKSRLFNWLSDLELFSILISALIHDFEHTGTSNNYHVNLNSNLALIYNDRSVLENHHLSAAFRLMKDDRYNIVQSLNANEYRELRNMVIEMVLATDMSAHFN---QVQVMKEG--------VLLPESLRKINILSYVLHSADISHPCKPWEMHHQWTNMVVEEFFRQGDNEKEFGLTCSPLCDRDSTLIPESQIGFINFIVEPCFLVLGDIQKAISILCPDETLLSDDPSEN 1352
            V  A    E L  CL QLE  + +R V        S+     F   L+K+   F+E+ S+    V +++ +T+  +++  P      P +           L  L  A    M      RK+  P      P   +          Q +++W  D+F  + L+ NHSL ++ + LL    L   F I  + L  +L  LE  Y    N YHN IHAADVA +  +++    L    +DLE+ + + +  +HD +H G +N Y +N N+ LA++YND SVLE HHL+ AF+L++D   + + +L+  +  + R +VI+MVLATDMS H +    ++ M E         ++L +   KI +L  ++H AD+S+P KP E++ QW   ++EE++RQGD EKE GL  SP+CDR +  I +SQ+GFI++IV P +    D      ++ PD   + D   EN
Sbjct:  146 VHCAHDTLEELDWCLDQLETIQTHRSV--------SEMASSKFRKMLNKELSHFAES-SKSGTQVSKFLITTYMDKEEDEPSIEIEVPTEVQGPSTSGPMTLSILKKAQTAAMNKISGVRKLRAPSHDGHVPEYGVNCAREIAVHMQRLDDWGPDVFKIDELSKNHSLTVVTFSLLRQRNLFKTFEIHQSTLVTYLLNLEHHY--RNNHYHNFIHAADVAQSMHVLLMSPVLTEVFTDLEVLAAIFAGAVHDVDHPGFTNQYLINSNNELAIMYNDESVLEQHHLAVAFKLLQDSNCDFLANLSRKQRLQFRKIVIDMVLATDMSKHMSLLADLKTMVEAKKVAGNNVIVLDKYNDKIQVLQSMIHLADLSNPTKPIELYQQWNQRIMEEYWRQGDKEKELGLEISPMCDRGNVTIEKSQVGFIDYIVHPLYETWAD------LVYPDAQNILDQLEEN 587
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BLAST of Phosphodiesterase vs. Ensembl Fly
Match: Pde1c (gene:FBgn0264815 transcript:FBtr0334137)

HSP 1 Score: 373.244 bits (957), Expect = 5.053e-123
Identity = 190/420 (45.24%), Postives = 278/420 (66.19%), Query Frame = 3 
Query:  213 LSKDEDIFSETDSE-LPENVQEWISSTFTK-----RQKVSPPPRQRLRSLINAVRVGMYFDRAFRKVSLPGSISAPPNAMIYLKQHINNWTFDIFHFNNLANNHSLKIMGYELLHSNQLISRFSIDINVLEAFLDKLEEGYSLHQNPYHNLIHAADVAHTCFLIVSKSRLFNWLSDLELFSILISALIHDFEHTGTSNNYHVNLNSNLALIYNDRSVLENHHLSAAFRLMKDDRYNIVQSLNANEYRELRNMVIEMVLATDMSAHFNQVQVMKEGVLLPE-SLRKINILSYVLHSADISHPCKPWEMHHQWTNMVVEEFFRQGDNEKEFGLTCSPLCDRDSTLIPESQIGFINFIVEPCFLVLGDIQKAI-SILCP-----DETLLSDDPSENSTVNGEKQIQ----TPWMDNLGNNKVK 1421
            L+ ++D  SE   + +P  V+EW++STFT+     R+K    P+   RS+ +A+R G++ DR +R+VS     + PP+ +  LK ++++WTFD+F     A+   +K + YEL +    I +F I   +LEAFL ++EEGY  ++NPYHN +HA DV  T    +  + L NWL+DLE+F+ L++AL+HD+EHTGT+NN+HV   S  AL+YNDR+VLENHH SA+FRL+++D YNI+  L+  E+RELR +VIEMVL TDM+ HF Q++ M++ + L E ++ K  +LS VLH  DISHP K W +HH+WT +++EEFFRQGD EKE GL  SPLCDR++TL+ ESQI FI+FIVEP   V+ D+ + I + + P       TL+  + + NST N    I     TP MD   +++ +
Sbjct:   95 LADEDDELSEVQPDAVPPEVREWLASTFTRQMATSRRKSDEKPK--FRSVAHAIRAGIFVDRMYRRVSSSALTAFPPDVVRLLK-NLDDWTFDVFALTEAASGQVVKYVAYELFNRYGSIHKFKIAPGILEAFLHRVEEGYCRYRNPYHNNLHAVDVMQTIHYCLCNTGLMNWLTDLEIFASLLAALLHDYEHTGTTNNFHVMSGSETALLYNDRAVLENHHASASFRLLREDEYNILSHLSREEFRELRGLVIEMVLGTDMTNHFQQMKAMRQLLTLQEATIDKQKVLSLVLHCCDISHPAKQWGVHHRWTMLLLEEFFRQGDLEKELGLPFSPLCDRNNTLVAESQICFIDFIVEPSMGVMSDMLELILAPIAPMNKSKPATLVEHETTANSTTNSAIVIPNSGITPSMDKPRDHRTE 511
[Close]
BLAST of Phosphodiesterase vs. Ensembl Fly
Match: Pde1c (gene:FBgn0264815 transcript:FBtr0334135)

HSP 1 Score: 375.17 bits (962), Expect = 6.253e-120
Identity = 194/439 (44.19%), Postives = 287/439 (65.38%), Query Frame = 3 
Query:  165 NLQDTSQFLDKAFLNS---LSKDEDIFSETDSE-LPENVQEWISSTFTK-----RQKVSPPPRQRLRSLINAVRVGMYFDRAFRKVSLPGSISAPPNAMIYLKQHINNWTFDIFHFNNLANNHSLKIMGYELLHSNQLISRFSIDINVLEAFLDKLEEGYSLHQNPYHNLIHAADVAHTCFLIVSKSRLFNWLSDLELFSILISALIHDFEHTGTSNNYHVNLNSNLALIYNDRSVLENHHLSAAFRLMKDDRYNIVQSLNANEYRELRNMVIEMVLATDMSAHFNQVQVMKEGVLLPE-SLRKINILSYVLHSADISHPCKPWEMHHQWTNMVVEEFFRQGDNEKEFGLTCSPLCDRDSTLIPESQIGFINFIVEPCFLVLGDIQKAI-SILCP-----DETLLSDDPSENSTVNGEKQIQ----TPWMDNLGNNKVK 1421
            NL   ++ L+  F++    L+ ++D  SE   + +P  V+EW++STFT+     R+K    P+   RS+ +A+R G++ DR +R+VS     + PP+ +  LK ++++WTFD+F     A+   +K + YEL +    I +F I   +LEAFL ++EEGY  ++NPYHN +HA DV  T    +  + L NWL+DLE+F+ L++AL+HD+EHTGT+NN+HV   S  AL+YNDR+VLENHH SA+FRL+++D YNI+  L+  E+RELR +VIEMVL TDM+ HF Q++ M++ + L E ++ K  +LS VLH  DISHP K W +HH+WT +++EEFFRQGD EKE GL  SPLCDR++TL+ ESQI FI+FIVEP   V+ D+ + I + + P       TL+  + + NST N    I     TP MD   +++ +
Sbjct:  423 NLHYAARVLEAVFIDESRRLADEDDELSEVQPDAVPPEVREWLASTFTRQMATSRRKSDEKPK--FRSVAHAIRAGIFVDRMYRRVSSSALTAFPPDVVRLLK-NLDDWTFDVFALTEAASGQVVKYVAYELFNRYGSIHKFKIAPGILEAFLHRVEEGYCRYRNPYHNNLHAVDVMQTIHYCLCNTGLMNWLTDLEIFASLLAALLHDYEHTGTTNNFHVMSGSETALLYNDRAVLENHHASASFRLLREDEYNILSHLSREEFRELRGLVIEMVLGTDMTNHFQQMKAMRQLLTLQEATIDKQKVLSLVLHCCDISHPAKQWGVHHRWTMLLLEEFFRQGDLEKELGLPFSPLCDRNNTLVAESQICFIDFIVEPSMGVMSDMLELILAPIAPMNKSKPATLVEHETTANSTTNSAIVIPNSGITPSMDKPRDHRTE 858
[Close]
BLAST of Phosphodiesterase vs. Ensembl Fly
Match: Pde1c (gene:FBgn0264815 transcript:FBtr0334136)

HSP 1 Score: 371.318 bits (952), Expect = 1.221e-119
Identity = 190/420 (45.24%), Postives = 278/420 (66.19%), Query Frame = 3 
Query:  213 LSKDEDIFSETDSE-LPENVQEWISSTFTK-----RQKVSPPPRQRLRSLINAVRVGMYFDRAFRKVSLPGSISAPPNAMIYLKQHINNWTFDIFHFNNLANNHSLKIMGYELLHSNQLISRFSIDINVLEAFLDKLEEGYSLHQNPYHNLIHAADVAHTCFLIVSKSRLFNWLSDLELFSILISALIHDFEHTGTSNNYHVNLNSNLALIYNDRSVLENHHLSAAFRLMKDDRYNIVQSLNANEYRELRNMVIEMVLATDMSAHFNQVQVMKEGVLLPE-SLRKINILSYVLHSADISHPCKPWEMHHQWTNMVVEEFFRQGDNEKEFGLTCSPLCDRDSTLIPESQIGFINFIVEPCFLVLGDIQKAI-SILCP-----DETLLSDDPSENSTVNGEKQIQ----TPWMDNLGNNKVK 1421
            L+ ++D  SE   + +P  V+EW++STFT+     R+K    P+   RS+ +A+R G++ DR +R+VS     + PP+ +  LK ++++WTFD+F     A+   +K + YEL +    I +F I   +LEAFL ++EEGY  ++NPYHN +HA DV  T    +  + L NWL+DLE+F+ L++AL+HD+EHTGT+NN+HV   S  AL+YNDR+VLENHH SA+FRL+++D YNI+  L+  E+RELR +VIEMVL TDM+ HF Q++ M++ + L E ++ K  +LS VLH  DISHP K W +HH+WT +++EEFFRQGD EKE GL  SPLCDR++TL+ ESQI FI+FIVEP   V+ D+ + I + + P       TL+  + + NST N    I     TP MD   +++ +
Sbjct:  324 LADEDDELSEVQPDAVPPEVREWLASTFTRQMATSRRKSDEKPK--FRSVAHAIRAGIFVDRMYRRVSSSALTAFPPDVVRLLK-NLDDWTFDVFALTEAASGQVVKYVAYELFNRYGSIHKFKIAPGILEAFLHRVEEGYCRYRNPYHNNLHAVDVMQTIHYCLCNTGLMNWLTDLEIFASLLAALLHDYEHTGTTNNFHVMSGSETALLYNDRAVLENHHASASFRLLREDEYNILSHLSREEFRELRGLVIEMVLGTDMTNHFQQMKAMRQLLTLQEATIDKQKVLSLVLHCCDISHPAKQWGVHHRWTMLLLEEFFRQGDLEKELGLPFSPLCDRNNTLVAESQICFIDFIVEPSMGVMSDMLELILAPIAPMNKSKPATLVEHETTANSTTNSAIVIPNSGITPSMDKPRDHRTE 740
[Close]
BLAST of Phosphodiesterase vs. Ensembl Fly
Match: Pde1c (gene:FBgn0264815 transcript:FBtr0334140)

HSP 1 Score: 371.318 bits (952), Expect = 1.221e-119
Identity = 190/420 (45.24%), Postives = 278/420 (66.19%), Query Frame = 3 
Query:  213 LSKDEDIFSETDSE-LPENVQEWISSTFTK-----RQKVSPPPRQRLRSLINAVRVGMYFDRAFRKVSLPGSISAPPNAMIYLKQHINNWTFDIFHFNNLANNHSLKIMGYELLHSNQLISRFSIDINVLEAFLDKLEEGYSLHQNPYHNLIHAADVAHTCFLIVSKSRLFNWLSDLELFSILISALIHDFEHTGTSNNYHVNLNSNLALIYNDRSVLENHHLSAAFRLMKDDRYNIVQSLNANEYRELRNMVIEMVLATDMSAHFNQVQVMKEGVLLPE-SLRKINILSYVLHSADISHPCKPWEMHHQWTNMVVEEFFRQGDNEKEFGLTCSPLCDRDSTLIPESQIGFINFIVEPCFLVLGDIQKAI-SILCP-----DETLLSDDPSENSTVNGEKQIQ----TPWMDNLGNNKVK 1421
            L+ ++D  SE   + +P  V+EW++STFT+     R+K    P+   RS+ +A+R G++ DR +R+VS     + PP+ +  LK ++++WTFD+F     A+   +K + YEL +    I +F I   +LEAFL ++EEGY  ++NPYHN +HA DV  T    +  + L NWL+DLE+F+ L++AL+HD+EHTGT+NN+HV   S  AL+YNDR+VLENHH SA+FRL+++D YNI+  L+  E+RELR +VIEMVL TDM+ HF Q++ M++ + L E ++ K  +LS VLH  DISHP K W +HH+WT +++EEFFRQGD EKE GL  SPLCDR++TL+ ESQI FI+FIVEP   V+ D+ + I + + P       TL+  + + NST N    I     TP MD   +++ +
Sbjct:  324 LADEDDELSEVQPDAVPPEVREWLASTFTRQMATSRRKSDEKPK--FRSVAHAIRAGIFVDRMYRRVSSSALTAFPPDVVRLLK-NLDDWTFDVFALTEAASGQVVKYVAYELFNRYGSIHKFKIAPGILEAFLHRVEEGYCRYRNPYHNNLHAVDVMQTIHYCLCNTGLMNWLTDLEIFASLLAALLHDYEHTGTTNNFHVMSGSETALLYNDRAVLENHHASASFRLLREDEYNILSHLSREEFRELRGLVIEMVLGTDMTNHFQQMKAMRQLLTLQEATIDKQKVLSLVLHCCDISHPAKQWGVHHRWTMLLLEEFFRQGDLEKELGLPFSPLCDRNNTLVAESQICFIDFIVEPSMGVMSDMLELILAPIAPMNKSKPATLVEHETTANSTTNSAIVIPNSGITPSMDKPRDHRTE 740
[Close]
BLAST of Phosphodiesterase vs. Ensembl Fly
Match: Pde1c (gene:FBgn0264815 transcript:FBtr0344148)

HSP 1 Score: 371.703 bits (953), Expect = 1.378e-119
Identity = 190/420 (45.24%), Postives = 278/420 (66.19%), Query Frame = 3 
Query:  213 LSKDEDIFSETDSE-LPENVQEWISSTFTK-----RQKVSPPPRQRLRSLINAVRVGMYFDRAFRKVSLPGSISAPPNAMIYLKQHINNWTFDIFHFNNLANNHSLKIMGYELLHSNQLISRFSIDINVLEAFLDKLEEGYSLHQNPYHNLIHAADVAHTCFLIVSKSRLFNWLSDLELFSILISALIHDFEHTGTSNNYHVNLNSNLALIYNDRSVLENHHLSAAFRLMKDDRYNIVQSLNANEYRELRNMVIEMVLATDMSAHFNQVQVMKEGVLLPE-SLRKINILSYVLHSADISHPCKPWEMHHQWTNMVVEEFFRQGDNEKEFGLTCSPLCDRDSTLIPESQIGFINFIVEPCFLVLGDIQKAI-SILCP-----DETLLSDDPSENSTVNGEKQIQ----TPWMDNLGNNKVK 1421
            L+ ++D  SE   + +P  V+EW++STFT+     R+K    P+   RS+ +A+R G++ DR +R+VS     + PP+ +  LK ++++WTFD+F     A+   +K + YEL +    I +F I   +LEAFL ++EEGY  ++NPYHN +HA DV  T    +  + L NWL+DLE+F+ L++AL+HD+EHTGT+NN+HV   S  AL+YNDR+VLENHH SA+FRL+++D YNI+  L+  E+RELR +VIEMVL TDM+ HF Q++ M++ + L E ++ K  +LS VLH  DISHP K W +HH+WT +++EEFFRQGD EKE GL  SPLCDR++TL+ ESQI FI+FIVEP   V+ D+ + I + + P       TL+  + + NST N    I     TP MD   +++ +
Sbjct:  345 LADEDDELSEVQPDAVPPEVREWLASTFTRQMATSRRKSDEKPK--FRSVAHAIRAGIFVDRMYRRVSSSALTAFPPDVVRLLK-NLDDWTFDVFALTEAASGQVVKYVAYELFNRYGSIHKFKIAPGILEAFLHRVEEGYCRYRNPYHNNLHAVDVMQTIHYCLCNTGLMNWLTDLEIFASLLAALLHDYEHTGTTNNFHVMSGSETALLYNDRAVLENHHASASFRLLREDEYNILSHLSREEFRELRGLVIEMVLGTDMTNHFQQMKAMRQLLTLQEATIDKQKVLSLVLHCCDISHPAKQWGVHHRWTMLLLEEFFRQGDLEKELGLPFSPLCDRNNTLVAESQICFIDFIVEPSMGVMSDMLELILAPIAPMNKSKPATLVEHETTANSTTNSAIVIPNSGITPSMDKPRDHRTE 761
[Close]
BLAST of Phosphodiesterase vs. Ensembl Zebrafish
Match: pde1a (phosphodiesterase 1A, calmodulin-dependent [Source:ZFIN;Acc:ZDB-GENE-090831-2])

HSP 1 Score: 404.06 bits (1037), Expect = 9.534e-135
Identity = 185/417 (44.36%), Postives = 289/417 (69.30%), Query Frame = 3 
Query:   72 SVQLARTLSENLKLCLSQLENGEINRIVLINNLQDTSQFLDKAFLNSLSK---DEDIFSETDSE-LPENVQEWISSTFTKRQKV---SPPPRQRLRSLINAVRVGMYFDRAFRKVSLPGSISAPPNAMIYLKQHINNWTFDIFHFNNLANNHSLKIMGYELLHSNQLISRFSIDINVLEAFLDKLEEGYSLHQNPYHNLIHAADVAHTCFLIVSKSRLFNWLSDLELFSILISALIHDFEHTGTSNNYHVNLNSNLALIYNDRSVLENHHLSAAFRLMKDDRYNIVQSLNANEYRELRNMVIEMVLATDMSAHFNQVQVMKEGVLLPESLRKINILSYVLHSADISHPCKPWEMHHQWTNMVVEEFFRQGDNEKEFGLTCSPLCDRDSTLIPESQIGFINFIVEPCFLVLGDIQKAI 1301
             +Q  +  S+ L+  + QL+ GE+N + L  N++  +  L+  +++   +    ED  S+  ++ +P  V++W++STFT++  V    P  + R RS+++AV+ G++ +R +R+ S    ++ PP+ +  LK  ++ W+FD+F     +++H+LK + YELL    LISRF I ++ L +F++ LE GYS H+NPYHNLIHAADV  T   ++  + + +WL++LE+ +++ +A IHDFEHTGT+NN+H+   S +A++YNDRSVLENHH+SAA+RLM++D  NI+ +L+ +++RELR +VIEMV++TDMS HF Q++ M+  +  PE + K   LS +LH+ADISHP K W++H++WT  ++EEFFRQGD E E GL  SPLCDR +T+I +SQIGFI+FIVEP F VL D  + I
Sbjct:   32 GMQKYKNTSQRLRCLVKQLDKGEVNVVDLRKNIEYAASVLEAVYIDETRRLLDTEDELSDIQADSVPMEVRDWLASTFTRKMGVVRRRPEEKPRFRSIVHAVQAGIFVERMYRRTSNMAGLTYPPSVITALKD-VDKWSFDVFKLQEASSDHALKFLVYELLTRYDLISRFRIPVSSLVSFVEALEIGYSKHRNPYHNLIHAADVTQTAHYLMLHTGVMHWLTELEILAMVFAAAIHDFEHTGTTNNFHIQTRSEVAILYNDRSVLENHHVSAAYRLMQEDEMNILVNLSKDDWRELRTLVIEMVMSTDMSCHFQQIKTMRNSLQQPEGIDKAKALSLMLHAADISHPAKGWKLHYRWTQALMEEFFRQGDKEAELGLPFSPLCDRKATMIAQSQIGFIDFIVEPTFSVLVDTTEKI 447
[Close]
BLAST of Phosphodiesterase vs. Ensembl Zebrafish
Match: pde1a (phosphodiesterase 1A, calmodulin-dependent [Source:ZFIN;Acc:ZDB-GENE-090831-2])

HSP 1 Score: 400.593 bits (1028), Expect = 8.662e-134
Identity = 183/406 (45.07%), Postives = 284/406 (69.95%), Query Frame = 3 
Query:  105 LKLCLSQLENGEINRIVLINNLQDTSQFLDKAFLNSLSK---DEDIFSETDSE-LPENVQEWISSTFTKRQKV---SPPPRQRLRSLINAVRVGMYFDRAFRKVSLPGSISAPPNAMIYLKQHINNWTFDIFHFNNLANNHSLKIMGYELLHSNQLISRFSIDINVLEAFLDKLEEGYSLHQNPYHNLIHAADVAHTCFLIVSKSRLFNWLSDLELFSILISALIHDFEHTGTSNNYHVNLNSNLALIYNDRSVLENHHLSAAFRLMKDDRYNIVQSLNANEYRELRNMVIEMVLATDMSAHFNQVQVMKEGVLLPESLRKINILSYVLHSADISHPCKPWEMHHQWTNMVVEEFFRQGDNEKEFGLTCSPLCDRDSTLIPESQIGFINFIVEPCFLVLGDIQKAI 1301
            L+  + QL+ GE+N + L  N++  +  L+  +++   +    ED  S+  ++ +P  V++W++STFT++  V    P  + R RS+++AV+ G++ +R +R+ S    ++ PP+ +  LK  ++ W+FD+F     +++H+LK + YELL    LISRF I ++ L +F++ LE GYS H+NPYHNLIHAADV  T   ++  + + +WL++LE+ +++ +A IHDFEHTGT+NN+H+   S +A++YNDRSVLENHH+SAA+RLM++D  NI+ +L+ +++RELR +VIEMV++TDMS HF Q++ M+  +  PE + K   LS +LH+ADISHP K W++H++WT  ++EEFFRQGD E E GL  SPLCDR +T+I +SQIGFI+FIVEP F VL D  + I
Sbjct:   19 LRCLVKQLDKGEVNVVDLRKNIEYAASVLEAVYIDETRRLLDTEDELSDIQADSVPMEVRDWLASTFTRKMGVVRRRPEEKPRFRSIVHAVQAGIFVERMYRRTSNMAGLTYPPSVITALKD-VDKWSFDVFKLQEASSDHALKFLVYELLTRYDLISRFRIPVSSLVSFVEALEIGYSKHRNPYHNLIHAADVTQTAHYLMLHTGVMHWLTELEILAMVFAAAIHDFEHTGTTNNFHIQTRSEVAILYNDRSVLENHHVSAAYRLMQEDEMNILVNLSKDDWRELRTLVIEMVMSTDMSCHFQQIKTMRNSLQQPEGIDKAKALSLMLHAADISHPAKGWKLHYRWTQALMEEFFRQGDKEAELGLPFSPLCDRKATMIAQSQIGFIDFIVEPTFSVLVDTTEKI 423
[Close]
BLAST of Phosphodiesterase vs. Ensembl Zebrafish
Match: CABZ01067973.1 (phosphodiesterase 1C, calmodulin-dependent b [Source:NCBI gene;Acc:100536162])

HSP 1 Score: 389.808 bits (1000), Expect = 2.807e-129
Identity = 185/413 (44.79%), Postives = 285/413 (69.01%), Query Frame = 3 
Query:   87 RTLSENLKLCLSQLENGEINRIVLINNLQDTSQFLDKAFLNS---LSKDEDIFSETDSE-LPENVQEWISSTFTKRQKV---SPPPRQRLRSLINAVRVGMYFDRAFRKVSLPGSISAPPNAMIYLKQHINNWTFDIFHFNNLANNHSLKIMGYELLHSNQLISRFSIDINVLEAFLDKLEEGYSLHQNPYHNLIHAADVAHTCFLIVSKSRLFNWLSDLELFSILISALIHDFEHTGTSNNYHVNLNSNLALIYNDRSVLENHHLSAAFRLMK-DDRYNIVQSLNANEYRELRNMVIEMVLATDMSAHFNQVQVMKEGVLLPESLRKINILSYVLHSADISHPCKPWEMHHQWTNMVVEEFFRQGDNEKEFGLTCSPLCDRDSTLIPESQIGFINFIVEPCFLVLGDIQKAI 1301
            +  S+ L+  + QLE GE + + L  NL+  +  L+  ++     L   ED  S+  S+ +P  V++W++STFT++  +       + R RS+++AV+ G++ +R +R+ S    +S PPN +  LK +++ W+FD+F  N  + +H+LK + YELL    LISRF I ++ L +F++ LE GYS ++NPYHNLIHAADV  T   ++ K+ + +W+++LE+F+++ +A IHD+EHTGT+NN+H+   S+ A++YNDRSVLE+HH+SA++RL++ DD  NI+ +L+ +++RE R +V+EMVLATDMS HF QV+ MK  +  PE + K   +S +LH+ADISHP K W++HH+WT  ++EEFF QGD E E GL  SPLCDR ST++ +SQIGFI+FIV P F VL D+ + I
Sbjct:   38 KKTSQRLRCLVKQLERGEASLVDLKKNLEYAATVLESVYIEETRRLVDTEDELSDIQSDSVPSEVRDWLASTFTRQMGLMLRRTEEKPRFRSIVHAVQAGIFVERMYRRTSNMVGLSYPPNVIAVLK-NVDRWSFDVFALNESSGDHALKFIFYELLTRYDLISRFKIPVSALVSFVEALEVGYSKYKNPYHNLIHAADVTQTVHYLLLKTGMVHWMTELEIFAMIFAAAIHDYEHTGTTNNFHIQTRSDAAILYNDRSVLESHHVSASYRLLQDDDEMNILYNLSKDDWREFRALVVEMVLATDMSCHFQQVKAMKNYLQQPEGIDKPKAISLLLHAADISHPAKTWDLHHRWTTSLLEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVVPTFTVLTDMTEKI 449
[Close]
BLAST of Phosphodiesterase vs. Ensembl Zebrafish
Match: pde4a (phosphodiesterase 4A, cAMP-specific [Source:ZFIN;Acc:ZDB-GENE-131125-7])

HSP 1 Score: 239.965 bits (611), Expect = 2.901e-70
Identity = 150/424 (35.38%), Postives = 233/424 (54.95%), Query Frame = 3 
Query:   78 QLARTLSENLKLCLSQLENGEINRIVLINNLQDTSQFLDKAFLNSLSKDEDIFSETDSELPENVQEWISSTFTKRQK----VSPPPRQRLRSL--INAVRVGMYFDRAFRKVSLP--GSISAPPNAMIYLKQHINNWTFDIFHFNNLANNHSLKIMGYELLHSNQLISRFSIDINVLEAFLDKLEEGYSLHQN-PYHNLIHAADVAHTCFLIVSKSRLFNWLSDLELFSILISALIHDFEHTGTSNNYHVNLNSNLALIYNDRSVLENHHLSAAFRLMKDDRYNIVQSLNANEYRELRNMVIEMVLATDMSAHFNQV----------QVMKEGVLLPESLR-KINILSYVLHSADISHPCKPWEMHHQWTNMVVEEFFRQGDNEKEFGLTCSPLCDRDSTLIPESQIGFINFIVEPCFLVLGDI 1289
            QLAR   E L  CL QLE  + +R V        S+     F   L+++    SE  S     V E+IS+TF  +Q      SP  R+R + +  I+ V+  +    +    +LP  G  +   +A+      +N W  +IFH    +NN  L  + + +     L+  F I ++    ++  LE+ Y  H N  YHN +HAADV  +  +++S   L    SDLE+ + L +A IHD +H G SN + +N NS LAL+YND SVLENHHL+  F+L+ ++  +I Q+L   + + LR +VI+MVLATDMS H + +          +V   GVL+ +    +I +L  ++H AD+S+P KP  ++ QWT  ++EEFF+QGD E+E G+  SP+CD+ +  + +SQ+GFI++IV P +   GD+
Sbjct:  220 QLARETLEELDWCLDQLETIQTHRSV--------SEMASNKFKRMLNRELSHLSEM-SRSGNQVSEYISTTFLDKQNEVEIPSPTLREREKPMSHISGVK-KLTHSSSLTSAALPRFGVKTEQEDALARELNDLNKWGLNIFHVAEFSNNRPLSCIMFAIFQERDLLKTFRIPVDTFITYVMTLEDHY--HANVAYHNSLHAADVTQSTHVLLSTPALDAVFSDLEILAALFAAAIHDVDHPGVSNQFLINTNSELALMYNDESVLENHHLAVGFKLLHEENCDIFQNLTKRQRQSLRKLVIDMVLATDMSKHMSLLADLKTMVETKKVTSSGVLMLDHYNDRIQVLRNMVHCADLSNPTKPLAVYRQWTERIMEEFFQQGDKERERGMEISPMCDKHTASVEKSQVGFIDYIVHPLWETWGDL 631
[Close]
BLAST of Phosphodiesterase vs. Ensembl Zebrafish
Match: pde4d (phosphodiesterase 4D, cAMP-specific [Source:ZFIN;Acc:ZDB-GENE-081105-16])

HSP 1 Score: 238.039 bits (606), Expect = 4.388e-70
Identity = 144/428 (33.64%), Postives = 231/428 (53.97%), Query Frame = 3 
Query:   78 QLARTLSENLKLCLSQLENGEINRIVLINNLQDTSQFLDKAFLNSLSKDEDIFSETDSELPENVQEWISSTFTKRQKV--SPPP--------RQRLRSLINAVRVGMYFDRAFRKVSLP--GSISAPPNAMIYLKQHINNWTFDIFHFNNLANNHSLKIMGYELLHSNQLISRFSIDINVLEAFLDKLEEGYSLHQN-PYHNLIHAADVAHTCFLIVSKSRLFNWLSDLELFSILISALIHDFEHTGTSNNYHVNLNSNLALIYNDRSVLENHHLSAAFRLMKDDRYNIVQSLNANEYRELRNMVIEMVLATDMSAHFNQV----------QVMKEGVLLPESLR-KINILSYVLHSADISHPCKPWEMHHQWTNMVVEEFFRQGDNEKEFGLTCSPLCDRDSTLIPESQIGFINFIVEPCFLVLGDI 1289
            +LA    E L  CL QLE  +    V        S+     F   L+++    SE  S     V E+ISSTF  +Q     P P        ++R  S I+ V+  +    +    ++P  G  +   + +    + +N W  ++F  +  + N  L +M Y +     L+  F I ++    +L  LE+ Y  H +  YHN IHAADV  +  +++S   L    +DLE+ + + ++ IHD +H G SN + +N NS LAL+YND SVLENHHL+  F+L++++  +I Q+L   + + LR MVI++VLATDMS H N +          +V   GVLL ++   +I +L  ++H AD+S+P KP +++ QWT+ ++EEFF QGD E+E G+  SP+CD+ +  + +SQ+GFI++IV P +    D+
Sbjct:  144 KLATETLEELDWCLDQLETLQTRHSV--------SEMASNKFKRMLNRELTHLSEM-SRSGNQVSEYISSTFLDKQNEVEMPSPQSQKDKEKKKRPMSQISGVK-KLTHSSSLTNSNIPRFGVKTETEDELAKELEDVNKWGLNVFKVSEFSGNRPLTVMMYTIFQERDLLKTFKIPLDTFITYLMTLEDHY--HADVAYHNNIHAADVTQSTHVLLSTPALEAVFTDLEILAAIFASAIHDVDHPGVSNQFLINTNSELALMYNDSSVLENHHLAVGFKLLQEENCDIFQNLTKKQRQSLRKMVIDIVLATDMSKHMNLLADLKTMVETKKVTSSGVLLLDNYSDRIQVLQNMVHCADLSNPTKPLQLYRQWTDRIMEEFFSQGDRERERGMEISPMCDKHNASVEKSQVGFIDYIVHPLWETWADL 559
[Close]
BLAST of Phosphodiesterase vs. Ensembl Xenopus
Match: arhgef39 (Rho guanine nucleotide exchange factor 39 [Source:Xenbase;Acc:XB-GENE-6257690])

HSP 1 Score: 396.741 bits (1018), Expect = 8.283e-133
Identity = 187/436 (42.89%), Postives = 295/436 (67.66%), Query Frame = 3 
Query:   57 ENKQISVQLARTLSENLKLCLSQLENGEINRIVLINNLQDTSQFLDKAFLNSLSK---DEDIFSE--TDSELPENVQEWISSTFTKR---QKVSPPPRQRLRSLINAVRVGMYFDRAFRKVSLPGSISAPPNAMIYLKQHINNWTFDIFHFNNLANNHSLKIMGYELLHSNQLISRFSIDINVLEAFLDKLEEGYSLHQNPYHNLIHAADVAHTCFLIVSKSRLFNWLSDLELFSILISALIHDFEHTGTSNNYHVNLNSNLALIYNDRSVLENHHLSAAFRLMKDDRYNIVQSLNANEYRELRNMVIEMVLATDMSAHFNQVQVMKEGVLLPESLRKINILSYVLHSADISHPCKPWEMHHQWTNMVVEEFFRQGDNEKEFGLTCSPLCDRDSTLIPESQIGFINFIVEPCFLVLGDIQKAISILCPDETLLSDD 1340
            E ++ + ++ + L   L+  + QLE G+IN   L NN++  +  L+  +++   +    ED  S+  TDS +P  V++W++STFT++   +K  P  + + RS+++AV+ G++ +R +R+ S    ++ P + +  +K  ++ W F++F  N  +  H+LK M YEL     L +RF I ++ L +F++ LE GYS ++NPYHNL+HAADV  T   I+  + + +WL++LE+ +++ +A IHDFEHTGT+NN+H+   S++A++YNDRSVLENHH+SAA+R+M+DD  NI  +L+ +++R+LR +VIEMVL+TDMS HF Q++ M+  +  PE + K   +S +LH+ADISHP KPW+MH +WTN+++EEFFRQGD E   GL  SPLCDR ST++ +SQIGFI+FIVEP F +L D  + I     +E   SD+
Sbjct:   19 ETRESNDKMVQRLQGILRCLVKQLEKGDINVTDLKNNIEYAASVLEAVYIDETRRLLDTEDELSDIHTDS-VPLEVRDWLASTFTRKMGMRKRRPEEKPKFRSIVHAVQAGIFVERMYRRSSNIAGLTYPSSVIASMKD-VDRWAFNVFTLNEASGEHALKFMVYELFTRYDLTNRFKIPVSNLVSFVEALEVGYSKYKNPYHNLVHAADVTQTVHYIILHTGIMHWLTELEILAMIFAAAIHDFEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRIMQDDEMNIFINLSKDDWRDLRTLVIEMVLSTDMSGHFQQLKTMRSTLQQPEGIDKAKAMSLILHAADISHPAKPWDMHLRWTNLLMEEFFRQGDKEAALGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFTLLTDSTEKIVFPLIEEAAKSDN 452
[Close]
BLAST of Phosphodiesterase vs. Ensembl Xenopus
Match: PDE1C (phosphodiesterase 1C [Source:NCBI gene;Acc:100495383])

HSP 1 Score: 395.971 bits (1016), Expect = 1.120e-132
Identity = 188/405 (46.42%), Postives = 286/405 (70.62%), Query Frame = 3 
Query:  117 LSQLENGEINRIVLINNLQDTSQFLDKAFLNSLSK---DEDIFSETDSE-LPENVQEWISSTFTKRQKV---SPPPRQRLRSLINAVRVGMYFDRAFRKVSLPGSISAPPNAMIYLKQHINNWTFDIFHFNNLANNHSLKIMGYELLHSNQLISRFSIDINVLEAFLDKLEEGYSLHQNPYHNLIHAADVAHTCFLIVSKSRLFNWLSDLELFSILISALIHDFEHTGTSNNYHVNLNSNLALIYNDRSVLENHHLSAAFRLMKDD-RYNIVQSLNANEYRELRNMVIEMVLATDMSAHFNQVQVMKEGVLLPESLRKINILSYVLHSADISHPCKPWEMHHQWTNMVVEEFFRQGDNEKEFGLTCSPLCDRDSTLIPESQIGFINFIVEPCFLVLGDIQKAISI 1307
            + QLE GE + + L  NL+  +  L+  +++   +    ED  S+  S+ +P  V++W++STFT++  +       + R RS+++AV+ G++ +R +R+ S    +S PP A+I + ++++ W+FD+F  N+ + +H LK + YELL    LI+RF I I+ L +F++ LE GY+ H+NPYHNLIHAADV  T    + KS L +WL++LE+F+++ +A +HD+EHTGT+NN+H+   S+ A++YNDRSVLENHH+SAA+RL++DD   NI+ +L+ +++RE R +VIEMVLATDMS HF+Q++ MK  +  PE + K   LS +LH+ADISHP K W++HH+WT  ++EEFFRQGD E E GL  SPLCDR+ST++ +SQIGFI+FIVEP F VL D+ + I +
Sbjct:   39 VKQLERGEASVVDLKKNLEYAATVLESVYIDETRRLLDTEDELSDIQSDSVPSEVRDWLASTFTRQMGMMLKRTEEKPRFRSIVHAVQAGIFVERMYRRTSNMVGLSYPP-AVIAVLKNVDKWSFDVFALNDASGDHGLKFIFYELLTRYDLINRFKIPISALVSFVEALEVGYTKHKNPYHNLIHAADVTQTVHYFLFKSGLVHWLTELEIFAMIFAAAVHDYEHTGTTNNFHIQTRSDSAILYNDRSVLENHHVSAAYRLLQDDEEMNILYNLSKDDWREFRALVIEMVLATDMSCHFHQIKQMKNALQQPEGIDKPKALSLLLHTADISHPAKNWDLHHRWTMSLLEEFFRQGDKEAELGLPFSPLCDRNSTMVAQSQIGFIDFIVEPTFTVLTDMIEKIVV 442
[Close]
BLAST of Phosphodiesterase vs. Ensembl Xenopus
Match: arhgef39 (Rho guanine nucleotide exchange factor 39 [Source:Xenbase;Acc:XB-GENE-6257690])

HSP 1 Score: 396.356 bits (1017), Expect = 1.596e-132
Identity = 187/436 (42.89%), Postives = 295/436 (67.66%), Query Frame = 3 
Query:   57 ENKQISVQLARTLSENLKLCLSQLENGEINRIVLINNLQDTSQFLDKAFLNSLSK---DEDIFSE--TDSELPENVQEWISSTFTKR---QKVSPPPRQRLRSLINAVRVGMYFDRAFRKVSLPGSISAPPNAMIYLKQHINNWTFDIFHFNNLANNHSLKIMGYELLHSNQLISRFSIDINVLEAFLDKLEEGYSLHQNPYHNLIHAADVAHTCFLIVSKSRLFNWLSDLELFSILISALIHDFEHTGTSNNYHVNLNSNLALIYNDRSVLENHHLSAAFRLMKDDRYNIVQSLNANEYRELRNMVIEMVLATDMSAHFNQVQVMKEGVLLPESLRKINILSYVLHSADISHPCKPWEMHHQWTNMVVEEFFRQGDNEKEFGLTCSPLCDRDSTLIPESQIGFINFIVEPCFLVLGDIQKAISILCPDETLLSDD 1340
            E ++ + ++ + L   L+  + QLE G+IN   L NN++  +  L+  +++   +    ED  S+  TDS +P  V++W++STFT++   +K  P  + + RS+++AV+ G++ +R +R+ S    ++ P + +  +K  ++ W F++F  N  +  H+LK M YEL     L +RF I ++ L +F++ LE GYS ++NPYHNL+HAADV  T   I+  + + +WL++LE+ +++ +A IHDFEHTGT+NN+H+   S++A++YNDRSVLENHH+SAA+R+M+DD  NI  +L+ +++R+LR +VIEMVL+TDMS HF Q++ M+  +  PE + K   +S +LH+ADISHP KPW+MH +WTN+++EEFFRQGD E   GL  SPLCDR ST++ +SQIGFI+FIVEP F +L D  + I     +E   SD+
Sbjct:   19 ETRESNDKMVQRLQGILRCLVKQLEKGDINVTDLKNNIEYAASVLEAVYIDETRRLLDTEDELSDIHTDS-VPLEVRDWLASTFTRKMGMRKRRPEEKPKFRSIVHAVQAGIFVERMYRRSSNIAGLTYPSSVIASMKD-VDRWAFNVFTLNEASGEHALKFMVYELFTRYDLTNRFKIPVSNLVSFVEALEVGYSKYKNPYHNLVHAADVTQTVHYIILHTGIMHWLTELEILAMIFAAAIHDFEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRIMQDDEMNIFINLSKDDWRDLRTLVIEMVLSTDMSGHFQQLKTMRSTLQQPEGIDKAKAMSLILHAADISHPAKPWDMHLRWTNLLMEEFFRQGDKEAALGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFTLLTDSTEKIVFPLIEEAAKSDN 452
[Close]
BLAST of Phosphodiesterase vs. Ensembl Xenopus
Match: PDE1C (phosphodiesterase 1C [Source:NCBI gene;Acc:100495383])

HSP 1 Score: 395.586 bits (1015), Expect = 1.642e-132
Identity = 188/405 (46.42%), Postives = 286/405 (70.62%), Query Frame = 3 
Query:  117 LSQLENGEINRIVLINNLQDTSQFLDKAFLNSLSK---DEDIFSETDSE-LPENVQEWISSTFTKRQKV---SPPPRQRLRSLINAVRVGMYFDRAFRKVSLPGSISAPPNAMIYLKQHINNWTFDIFHFNNLANNHSLKIMGYELLHSNQLISRFSIDINVLEAFLDKLEEGYSLHQNPYHNLIHAADVAHTCFLIVSKSRLFNWLSDLELFSILISALIHDFEHTGTSNNYHVNLNSNLALIYNDRSVLENHHLSAAFRLMKDD-RYNIVQSLNANEYRELRNMVIEMVLATDMSAHFNQVQVMKEGVLLPESLRKINILSYVLHSADISHPCKPWEMHHQWTNMVVEEFFRQGDNEKEFGLTCSPLCDRDSTLIPESQIGFINFIVEPCFLVLGDIQKAISI 1307
            + QLE GE + + L  NL+  +  L+  +++   +    ED  S+  S+ +P  V++W++STFT++  +       + R RS+++AV+ G++ +R +R+ S    +S PP A+I + ++++ W+FD+F  N+ + +H LK + YELL    LI+RF I I+ L +F++ LE GY+ H+NPYHNLIHAADV  T    + KS L +WL++LE+F+++ +A +HD+EHTGT+NN+H+   S+ A++YNDRSVLENHH+SAA+RL++DD   NI+ +L+ +++RE R +VIEMVLATDMS HF+Q++ MK  +  PE + K   LS +LH+ADISHP K W++HH+WT  ++EEFFRQGD E E GL  SPLCDR+ST++ +SQIGFI+FIVEP F VL D+ + I +
Sbjct:   39 VKQLERGEASVVDLKKNLEYAATVLESVYIDETRRLLDTEDELSDIQSDSVPSEVRDWLASTFTRQMGMMLKRTEEKPRFRSIVHAVQAGIFVERMYRRTSNMVGLSYPP-AVIAVLKNVDKWSFDVFALNDASGDHGLKFIFYELLTRYDLINRFKIPISALVSFVEALEVGYTKHKNPYHNLIHAADVTQTVHYFLFKSGLVHWLTELEIFAMIFAAAVHDYEHTGTTNNFHIQTRSDSAILYNDRSVLENHHVSAAYRLLQDDEEMNILYNLSKDDWREFRALVIEMVLATDMSCHFHQIKQMKNALQQPEGIDKPKALSLLLHTADISHPAKNWDLHHRWTMSLLEEFFRQGDKEAELGLPFSPLCDRNSTMVAQSQIGFIDFIVEPTFTVLTDMIEKIVV 442
[Close]
BLAST of Phosphodiesterase vs. Ensembl Xenopus
Match: PDE1C (phosphodiesterase 1C [Source:NCBI gene;Acc:100495383])

HSP 1 Score: 395.201 bits (1014), Expect = 5.758e-132
Identity = 190/415 (45.78%), Postives = 291/415 (70.12%), Query Frame = 3 
Query:   87 RTLSENLKLCLSQLENGEINRIVLINNLQDTSQFLDKAFLNSLSK---DEDIFSETDSE-LPENVQEWISSTFTKRQKV---SPPPRQRLRSLINAVRVGMYFDRAFRKVSLPGSISAPPNAMIYLKQHINNWTFDIFHFNNLANNHSLKIMGYELLHSNQLISRFSIDINVLEAFLDKLEEGYSLHQNPYHNLIHAADVAHTCFLIVSKSRLFNWLSDLELFSILISALIHDFEHTGTSNNYHVNLNSNLALIYNDRSVLENHHLSAAFRLMKDDR-YNIVQSLNANEYRELRNMVIEMVLATDMSAHFNQVQVMKEGVLLPESLRKINILSYVLHSADISHPCKPWEMHHQWTNMVVEEFFRQGDNEKEFGLTCSPLCDRDSTLIPESQIGFINFIVEPCFLVLGDIQKAISI 1307
            +  S+ L+  + QLE GE + + L  NL+  +  L+  +++   +    ED  S+  S+ +P  V++W++STFT++  +       + R RS+++AV+ G++ +R +R+ S    +S PP A+I + ++++ W+FD+F  N+ + +H LK + YELL    LI+RF I I+ L +F++ LE GY+ H+NPYHNLIHAADV  T    + KS L +WL++LE+F+++ +A +HD+EHTGT+NN+H+   S+ A++YNDRSVLENHH+SAA+RL++DD   NI+ +L+ +++RE R +VIEMVLATDMS HF+Q++ MK  +  PE + K   LS +LH+ADISHP K W++HH+WT  ++EEFFRQGD E E GL  SPLCDR+ST++ +SQIGFI+FIVEP F VL D+ + I +
Sbjct:   38 KKTSQRLRCLVKQLERGEASVVDLKKNLEYAATVLESVYIDETRRLLDTEDELSDIQSDSVPSEVRDWLASTFTRQMGMMLKRTEEKPRFRSIVHAVQAGIFVERMYRRTSNMVGLSYPP-AVIAVLKNVDKWSFDVFALNDASGDHGLKFIFYELLTRYDLINRFKIPISALVSFVEALEVGYTKHKNPYHNLIHAADVTQTVHYFLFKSGL-HWLTELEIFAMIFAAAVHDYEHTGTTNNFHIQTRSDSAILYNDRSVLENHHVSAAYRLLQDDEEMNILYNLSKDDWREFRALVIEMVLATDMSCHFHQIKQMKNALQQPEGIDKPKALSLLLHTADISHPAKNWDLHHRWTMSLLEEFFRQGDKEAELGLPFSPLCDRNSTMVAQSQIGFIDFIVEPTFTVLTDMIEKIVV 450
[Close]
BLAST of Phosphodiesterase vs. Ensembl Mouse
Match: Pde1c (phosphodiesterase 1C [Source:MGI Symbol;Acc:MGI:108413])

HSP 1 Score: 405.601 bits (1041), Expect = 1.783e-135
Identity = 194/435 (44.60%), Postives = 296/435 (68.05%), Query Frame = 3 
Query:   87 RTLSENLKLCLSQLENGEINRIVLINNLQDTSQFLDKAFLNSLSK---DEDIFSETDSE-LPENVQEWISSTFTKRQKV---SPPPRQRLRSLINAVRVGMYFDRAFRKVSLPGSISAPPNAMIYLKQHINNWTFDIFHFNNLANNHSLKIMGYELLHSNQLISRFSIDINVLEAFLDKLEEGYSLHQNPYHNLIHAADVAHTCFLIVSKSRLFNWLSDLELFSILISALIHDFEHTGTSNNYHVNLNSNLALIYNDRSVLENHHLSAAFRLMK-DDRYNIVQSLNANEYRELRNMVIEMVLATDMSAHFNQVQVMKEGVLLPESLRKINILSYVLHSADISHPCKPWEMHHQWTNMVVEEFFRQGDNEKEFGLTCSPLCDRDSTLIPESQIGFINFIVEPCFLVLGDI-QKAISILCPDETLLSDDPSENSTVN 1364
            +  S+ L+  + QLE GE + + L  NL+  +  L+  +++   +    ED  S+  S+ +P  V++W++STFT++  +       + R +S+++AV+ G++ +R +R+ S    +S PP  +  LK  ++ W+FD+F  N  + +H+LK + YELL    LISRF I I+ L +F++ LE GYS H+NPYHNL+HAADV  T   ++ K+ + NWL++LE+F+I+ SA IHD+EHTGT+NN+H+   S+ A++YNDRSVLENHHLSAA+RL++ D+  NI+ +L+ +++RE R +VIEMV+ATDMS HF Q++ MK  +  PE++ K   LS +LH+ADISHP K W++HH+WT  ++EEFFRQGD E E GL  SPLCDR ST++ +SQ+GFI+FIVEP F VL D+ +K +S L  + +         S++N
Sbjct:   10 KKTSQRLRSLVKQLERGEASVVDLKKNLEYAATVLESVYIDETRRLLDTEDELSDIQSDAVPSEVRDWLASTFTRQMGMMLRRSDEKPRFKSIVHAVQAGIFVERMYRRTSNMVGLSYPPAVIDALKD-VDTWSFDVFSLNEASGDHALKFIFYELLTRYDLISRFKIPISALVSFVEALEVGYSKHKNPYHNLMHAADVTQTVHYLLYKTGVANWLTELEIFAIIFSAAIHDYEHTGTTNNFHIQTRSDPAILYNDRSVLENHHLSAAYRLLQEDEEMNILVNLSKDDWREFRTLVIEMVMATDMSCHFQQIKAMKTALQQPEAIEKPKALSLMLHTADISHPAKAWDLHHRWTMSLLEEFFRQGDREAELGLPFSPLCDRKSTMVAQSQVGFIDFIVEPTFTVLTDMTEKIVSPLIDESSQTGGTGQRRSSLN 443
[Close]
BLAST of Phosphodiesterase vs. Ensembl Mouse
Match: Pde1c (phosphodiesterase 1C [Source:MGI Symbol;Acc:MGI:108413])

HSP 1 Score: 405.216 bits (1040), Expect = 5.621e-135
Identity = 194/435 (44.60%), Postives = 296/435 (68.05%), Query Frame = 3 
Query:   87 RTLSENLKLCLSQLENGEINRIVLINNLQDTSQFLDKAFLNSLSK---DEDIFSETDSE-LPENVQEWISSTFTKRQKV---SPPPRQRLRSLINAVRVGMYFDRAFRKVSLPGSISAPPNAMIYLKQHINNWTFDIFHFNNLANNHSLKIMGYELLHSNQLISRFSIDINVLEAFLDKLEEGYSLHQNPYHNLIHAADVAHTCFLIVSKSRLFNWLSDLELFSILISALIHDFEHTGTSNNYHVNLNSNLALIYNDRSVLENHHLSAAFRLMK-DDRYNIVQSLNANEYRELRNMVIEMVLATDMSAHFNQVQVMKEGVLLPESLRKINILSYVLHSADISHPCKPWEMHHQWTNMVVEEFFRQGDNEKEFGLTCSPLCDRDSTLIPESQIGFINFIVEPCFLVLGDI-QKAISILCPDETLLSDDPSENSTVN 1364
            +  S+ L+  + QLE GE + + L  NL+  +  L+  +++   +    ED  S+  S+ +P  V++W++STFT++  +       + R +S+++AV+ G++ +R +R+ S    +S PP  +  LK  ++ W+FD+F  N  + +H+LK + YELL    LISRF I I+ L +F++ LE GYS H+NPYHNL+HAADV  T   ++ K+ + NWL++LE+F+I+ SA IHD+EHTGT+NN+H+   S+ A++YNDRSVLENHHLSAA+RL++ D+  NI+ +L+ +++RE R +VIEMV+ATDMS HF Q++ MK  +  PE++ K   LS +LH+ADISHP K W++HH+WT  ++EEFFRQGD E E GL  SPLCDR ST++ +SQ+GFI+FIVEP F VL D+ +K +S L  + +         S++N
Sbjct:   38 KKTSQRLRSLVKQLERGEASVVDLKKNLEYAATVLESVYIDETRRLLDTEDELSDIQSDAVPSEVRDWLASTFTRQMGMMLRRSDEKPRFKSIVHAVQAGIFVERMYRRTSNMVGLSYPPAVIDALKD-VDTWSFDVFSLNEASGDHALKFIFYELLTRYDLISRFKIPISALVSFVEALEVGYSKHKNPYHNLMHAADVTQTVHYLLYKTGVANWLTELEIFAIIFSAAIHDYEHTGTTNNFHIQTRSDPAILYNDRSVLENHHLSAAYRLLQEDEEMNILVNLSKDDWREFRTLVIEMVMATDMSCHFQQIKAMKTALQQPEAIEKPKALSLMLHTADISHPAKAWDLHHRWTMSLLEEFFRQGDREAELGLPFSPLCDRKSTMVAQSQVGFIDFIVEPTFTVLTDMTEKIVSPLIDESSQTGGTGQRRSSLN 471
[Close]
BLAST of Phosphodiesterase vs. Ensembl Mouse
Match: Pde1c (phosphodiesterase 1C [Source:MGI Symbol;Acc:MGI:108413])

HSP 1 Score: 405.216 bits (1040), Expect = 5.621e-135
Identity = 194/435 (44.60%), Postives = 296/435 (68.05%), Query Frame = 3 
Query:   87 RTLSENLKLCLSQLENGEINRIVLINNLQDTSQFLDKAFLNSLSK---DEDIFSETDSE-LPENVQEWISSTFTKRQKV---SPPPRQRLRSLINAVRVGMYFDRAFRKVSLPGSISAPPNAMIYLKQHINNWTFDIFHFNNLANNHSLKIMGYELLHSNQLISRFSIDINVLEAFLDKLEEGYSLHQNPYHNLIHAADVAHTCFLIVSKSRLFNWLSDLELFSILISALIHDFEHTGTSNNYHVNLNSNLALIYNDRSVLENHHLSAAFRLMK-DDRYNIVQSLNANEYRELRNMVIEMVLATDMSAHFNQVQVMKEGVLLPESLRKINILSYVLHSADISHPCKPWEMHHQWTNMVVEEFFRQGDNEKEFGLTCSPLCDRDSTLIPESQIGFINFIVEPCFLVLGDI-QKAISILCPDETLLSDDPSENSTVN 1364
            +  S+ L+  + QLE GE + + L  NL+  +  L+  +++   +    ED  S+  S+ +P  V++W++STFT++  +       + R +S+++AV+ G++ +R +R+ S    +S PP  +  LK  ++ W+FD+F  N  + +H+LK + YELL    LISRF I I+ L +F++ LE GYS H+NPYHNL+HAADV  T   ++ K+ + NWL++LE+F+I+ SA IHD+EHTGT+NN+H+   S+ A++YNDRSVLENHHLSAA+RL++ D+  NI+ +L+ +++RE R +VIEMV+ATDMS HF Q++ MK  +  PE++ K   LS +LH+ADISHP K W++HH+WT  ++EEFFRQGD E E GL  SPLCDR ST++ +SQ+GFI+FIVEP F VL D+ +K +S L  + +         S++N
Sbjct:   38 KKTSQRLRSLVKQLERGEASVVDLKKNLEYAATVLESVYIDETRRLLDTEDELSDIQSDAVPSEVRDWLASTFTRQMGMMLRRSDEKPRFKSIVHAVQAGIFVERMYRRTSNMVGLSYPPAVIDALKD-VDTWSFDVFSLNEASGDHALKFIFYELLTRYDLISRFKIPISALVSFVEALEVGYSKHKNPYHNLMHAADVTQTVHYLLYKTGVANWLTELEIFAIIFSAAIHDYEHTGTTNNFHIQTRSDPAILYNDRSVLENHHLSAAYRLLQEDEEMNILVNLSKDDWREFRTLVIEMVMATDMSCHFQQIKAMKTALQQPEAIEKPKALSLMLHTADISHPAKAWDLHHRWTMSLLEEFFRQGDREAELGLPFSPLCDRKSTMVAQSQVGFIDFIVEPTFTVLTDMTEKIVSPLIDESSQTGGTGQRRSSLN 471
[Close]
BLAST of Phosphodiesterase vs. Ensembl Mouse
Match: Pde1c (phosphodiesterase 1C [Source:MGI Symbol;Acc:MGI:108413])

HSP 1 Score: 405.601 bits (1041), Expect = 9.280e-135
Identity = 194/435 (44.60%), Postives = 296/435 (68.05%), Query Frame = 3 
Query:   87 RTLSENLKLCLSQLENGEINRIVLINNLQDTSQFLDKAFLNSLSK---DEDIFSETDSE-LPENVQEWISSTFTKRQKV---SPPPRQRLRSLINAVRVGMYFDRAFRKVSLPGSISAPPNAMIYLKQHINNWTFDIFHFNNLANNHSLKIMGYELLHSNQLISRFSIDINVLEAFLDKLEEGYSLHQNPYHNLIHAADVAHTCFLIVSKSRLFNWLSDLELFSILISALIHDFEHTGTSNNYHVNLNSNLALIYNDRSVLENHHLSAAFRLMK-DDRYNIVQSLNANEYRELRNMVIEMVLATDMSAHFNQVQVMKEGVLLPESLRKINILSYVLHSADISHPCKPWEMHHQWTNMVVEEFFRQGDNEKEFGLTCSPLCDRDSTLIPESQIGFINFIVEPCFLVLGDI-QKAISILCPDETLLSDDPSENSTVN 1364
            +  S+ L+  + QLE GE + + L  NL+  +  L+  +++   +    ED  S+  S+ +P  V++W++STFT++  +       + R +S+++AV+ G++ +R +R+ S    +S PP  +  LK  ++ W+FD+F  N  + +H+LK + YELL    LISRF I I+ L +F++ LE GYS H+NPYHNL+HAADV  T   ++ K+ + NWL++LE+F+I+ SA IHD+EHTGT+NN+H+   S+ A++YNDRSVLENHHLSAA+RL++ D+  NI+ +L+ +++RE R +VIEMV+ATDMS HF Q++ MK  +  PE++ K   LS +LH+ADISHP K W++HH+WT  ++EEFFRQGD E E GL  SPLCDR ST++ +SQ+GFI+FIVEP F VL D+ +K +S L  + +         S++N
Sbjct:   38 KKTSQRLRSLVKQLERGEASVVDLKKNLEYAATVLESVYIDETRRLLDTEDELSDIQSDAVPSEVRDWLASTFTRQMGMMLRRSDEKPRFKSIVHAVQAGIFVERMYRRTSNMVGLSYPPAVIDALKD-VDTWSFDVFSLNEASGDHALKFIFYELLTRYDLISRFKIPISALVSFVEALEVGYSKHKNPYHNLMHAADVTQTVHYLLYKTGVANWLTELEIFAIIFSAAIHDYEHTGTTNNFHIQTRSDPAILYNDRSVLENHHLSAAYRLLQEDEEMNILVNLSKDDWREFRTLVIEMVMATDMSCHFQQIKAMKTALQQPEAIEKPKALSLMLHTADISHPAKAWDLHHRWTMSLLEEFFRQGDREAELGLPFSPLCDRKSTMVAQSQVGFIDFIVEPTFTVLTDMTEKIVSPLIDESSQTGGTGQRRSSLN 471
[Close]
BLAST of Phosphodiesterase vs. Ensembl Mouse
Match: Pde1c (phosphodiesterase 1C [Source:MGI Symbol;Acc:MGI:108413])

HSP 1 Score: 405.601 bits (1041), Expect = 9.280e-135
Identity = 194/435 (44.60%), Postives = 296/435 (68.05%), Query Frame = 3 
Query:   87 RTLSENLKLCLSQLENGEINRIVLINNLQDTSQFLDKAFLNSLSK---DEDIFSETDSE-LPENVQEWISSTFTKRQKV---SPPPRQRLRSLINAVRVGMYFDRAFRKVSLPGSISAPPNAMIYLKQHINNWTFDIFHFNNLANNHSLKIMGYELLHSNQLISRFSIDINVLEAFLDKLEEGYSLHQNPYHNLIHAADVAHTCFLIVSKSRLFNWLSDLELFSILISALIHDFEHTGTSNNYHVNLNSNLALIYNDRSVLENHHLSAAFRLMK-DDRYNIVQSLNANEYRELRNMVIEMVLATDMSAHFNQVQVMKEGVLLPESLRKINILSYVLHSADISHPCKPWEMHHQWTNMVVEEFFRQGDNEKEFGLTCSPLCDRDSTLIPESQIGFINFIVEPCFLVLGDI-QKAISILCPDETLLSDDPSENSTVN 1364
            +  S+ L+  + QLE GE + + L  NL+  +  L+  +++   +    ED  S+  S+ +P  V++W++STFT++  +       + R +S+++AV+ G++ +R +R+ S    +S PP  +  LK  ++ W+FD+F  N  + +H+LK + YELL    LISRF I I+ L +F++ LE GYS H+NPYHNL+HAADV  T   ++ K+ + NWL++LE+F+I+ SA IHD+EHTGT+NN+H+   S+ A++YNDRSVLENHHLSAA+RL++ D+  NI+ +L+ +++RE R +VIEMV+ATDMS HF Q++ MK  +  PE++ K   LS +LH+ADISHP K W++HH+WT  ++EEFFRQGD E E GL  SPLCDR ST++ +SQ+GFI+FIVEP F VL D+ +K +S L  + +         S++N
Sbjct:   38 KKTSQRLRSLVKQLERGEASVVDLKKNLEYAATVLESVYIDETRRLLDTEDELSDIQSDAVPSEVRDWLASTFTRQMGMMLRRSDEKPRFKSIVHAVQAGIFVERMYRRTSNMVGLSYPPAVIDALKD-VDTWSFDVFSLNEASGDHALKFIFYELLTRYDLISRFKIPISALVSFVEALEVGYSKHKNPYHNLMHAADVTQTVHYLLYKTGVANWLTELEIFAIIFSAAIHDYEHTGTTNNFHIQTRSDPAILYNDRSVLENHHLSAAYRLLQEDEEMNILVNLSKDDWREFRTLVIEMVMATDMSCHFQQIKAMKTALQQPEAIEKPKALSLMLHTADISHPAKAWDLHHRWTMSLLEEFFRQGDREAELGLPFSPLCDRKSTMVAQSQVGFIDFIVEPTFTVLTDMTEKIVSPLIDESSQTGGTGQRRSSLN 471
[Close]
BLAST of Phosphodiesterase vs. UniProt/SwissProt
Match: sp|Q14123|PDE1C_HUMAN (Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C OS=Homo sapiens OX=9606 GN=PDE1C PE=1 SV=1)

HSP 1 Score: 407.142 bits (1045), Expect = 6.132e-134
Identity = 194/421 (46.08%), Postives = 291/421 (69.12%), Query Frame = 3 
Query:   87 RTLSENLKLCLSQLENGEINRIVLINNLQDTSQFLDKAFLNSLSK---DEDIFSETDSE-LPENVQEWISSTFTKRQKV---SPPPRQRLRSLINAVRVGMYFDRAFRKVSLPGSISAPPNAMIYLKQHINNWTFDIFHFNNLANNHSLKIMGYELLHSNQLISRFSIDINVLEAFLDKLEEGYSLHQNPYHNLIHAADVAHTCFLIVSKSRLFNWLSDLELFSILISALIHDFEHTGTSNNYHVNLNSNLALIYNDRSVLENHHLSAAFRLMKDD-RYNIVQSLNANEYRELRNMVIEMVLATDMSAHFNQVQVMKEGVLLPESLRKINILSYVLHSADISHPCKPWEMHHQWTNMVVEEFFRQGDNEKEFGLTCSPLCDRDSTLIPESQIGFINFIVEPCFLVLGDIQKAISILCPDET 1325
            +  S+ L+  + QLE GE + + L  NL+  +  L+  +++   +    ED  S+  S+ +P  V++W++STFT++  +       + R +S+++AV+ G++ +R +R+ S    +S PP A+I   + ++ W+FD+F  N  + +H+LK + YELL    LISRF I I+ L +F++ LE GYS H+NPYHNL+HAADV  T   ++ K+ + NWL++LE+F+I+ SA IHD+EHTGT+NN+H+   S+ A++YNDRSVLENHHLSAA+RL++DD   NI+ +L+ +++RE R +VIEMV+ATDMS HF Q++ MK  +  PE++ K   LS +LH+ADISHP K W++HH+WT  ++EEFFRQGD E E GL  SPLCDR ST++ +SQ+GFI+FIVEP F VL D+ + I     DET
Sbjct:   38 KKTSQRLRSLVKQLERGEASVVDLKKNLEYAATVLESVYIDETRRLLDTEDELSDIQSDAVPSEVRDWLASTFTRQMGMMLRRSDEKPRFKSIVHAVQAGIFVERMYRRTSNMVGLSYPP-AVIEALKDVDKWSFDVFSLNEASGDHALKFIFYELLTRYDLISRFKIPISALVSFVEALEVGYSKHKNPYHNLMHAADVTQTVHYLLYKTGVANWLTELEIFAIIFSAAIHDYEHTGTTNNFHIQTRSDPAILYNDRSVLENHHLSAAYRLLQDDEEMNILINLSKDDWREFRTLVIEMVMATDMSCHFQQIKAMKTALQQPEAIEKPKALSLMLHTADISHPAKAWDLHHRWTMSLLEEFFRQGDREAELGLPFSPLCDRKSTMVAQSQVGFIDFIVEPTFTVLTDMTEKIVSPLIDET 457
[Close]
BLAST of Phosphodiesterase vs. UniProt/SwissProt
Match: sp|Q64338|PDE1C_MOUSE (Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C OS=Mus musculus OX=10090 GN=Pde1c PE=1 SV=2)

HSP 1 Score: 405.216 bits (1040), Expect = 3.055e-133
Identity = 194/435 (44.60%), Postives = 296/435 (68.05%), Query Frame = 3 
Query:   87 RTLSENLKLCLSQLENGEINRIVLINNLQDTSQFLDKAFLNSLSK---DEDIFSETDSE-LPENVQEWISSTFTKRQKV---SPPPRQRLRSLINAVRVGMYFDRAFRKVSLPGSISAPPNAMIYLKQHINNWTFDIFHFNNLANNHSLKIMGYELLHSNQLISRFSIDINVLEAFLDKLEEGYSLHQNPYHNLIHAADVAHTCFLIVSKSRLFNWLSDLELFSILISALIHDFEHTGTSNNYHVNLNSNLALIYNDRSVLENHHLSAAFRLMK-DDRYNIVQSLNANEYRELRNMVIEMVLATDMSAHFNQVQVMKEGVLLPESLRKINILSYVLHSADISHPCKPWEMHHQWTNMVVEEFFRQGDNEKEFGLTCSPLCDRDSTLIPESQIGFINFIVEPCFLVLGDI-QKAISILCPDETLLSDDPSENSTVN 1364
            +  S+ L+  + QLE GE + + L  NL+  +  L+  +++   +    ED  S+  S+ +P  V++W++STFT++  +       + R +S+++AV+ G++ +R +R+ S    +S PP  +  LK  ++ W+FD+F  N  + +H+LK + YELL    LISRF I I+ L +F++ LE GYS H+NPYHNL+HAADV  T   ++ K+ + NWL++LE+F+I+ SA IHD+EHTGT+NN+H+   S+ A++YNDRSVLENHHLSAA+RL++ D+  NI+ +L+ +++RE R +VIEMV+ATDMS HF Q++ MK  +  PE++ K   LS +LH+ADISHP K W++HH+WT  ++EEFFRQGD E E GL  SPLCDR ST++ +SQ+GFI+FIVEP F VL D+ +K +S L  + +         S++N
Sbjct:   38 KKTSQRLRSLVKQLERGEASVVDLKKNLEYAATVLESVYIDETRRLLDTEDELSDIQSDAVPSEVRDWLASTFTRQMGMMLRRSDEKPRFKSIVHAVQAGIFVERMYRRTSNMVGLSYPPAVIDALKD-VDTWSFDVFSLNEASGDHALKFIFYELLTRYDLISRFKIPISALVSFVEALEVGYSKHKNPYHNLMHAADVTQTVHYLLYKTGVANWLTELEIFAIIFSAAIHDYEHTGTTNNFHIQTRSDPAILYNDRSVLENHHLSAAYRLLQEDEEMNILVNLSKDDWREFRTLVIEMVMATDMSCHFQQIKAMKTALQQPEAIEKPKALSLMLHTADISHPAKAWDLHHRWTMSLLEEFFRQGDREAELGLPFSPLCDRKSTMVAQSQVGFIDFIVEPTFTVLTDMTEKIVSPLIDESSQTGGTGQRRSSLN 471
[Close]
BLAST of Phosphodiesterase vs. UniProt/SwissProt
Match: sp|Q63421|PDE1C_RAT (Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C OS=Rattus norvegicus OX=10116 GN=Pde1c PE=1 SV=1)

HSP 1 Score: 402.905 bits (1034), Expect = 1.397e-131
Identity = 192/415 (46.27%), Postives = 287/415 (69.16%), Query Frame = 3 
Query:  105 LKLCLSQLENGEINRIVLINNLQDTSQFLDKAFLNSLSK---DEDIFSETDSE-LPENVQEWISSTFTKRQKV---SPPPRQRLRSLINAVRVGMYFDRAFRKVSLPGSISAPPNAMIYLKQHINNWTFDIFHFNNLANNHSLKIMGYELLHSNQLISRFSIDINVLEAFLDKLEEGYSLHQNPYHNLIHAADVAHTCFLIVSKSRLFNWLSDLELFSILISALIHDFEHTGTSNNYHVNLNSNLALIYNDRSVLENHHLSAAFRLMK-DDRYNIVQSLNANEYRELRNMVIEMVLATDMSAHFNQVQVMKEGVLLPESLRKINILSYVLHSADISHPCKPWEMHHQWTNMVVEEFFRQGDNEKEFGLTCSPLCDRDSTLIPESQIGFINFIVEPCFLVLGDIQKAISILCPDET 1325
            L+  + QLE GE + + L  NL+  +  L+  +++   +    ED  S+  S+ +P  V++W++STFT++  +       + R +S+++AV+ G++ +R +R+ S    +S PP  +  LK  ++ W+FD+F  N  + +H+LK + YELL    LISRF I I+ L +F++ LE GYS H+NPYHNL+HAADV  T   ++ K+ + NWL++LE+F+I+ SA IHD+EHTGT+NN+H+   S+ A++YNDRSVLENHHLSAA+RL++ D+  NI+ +L+ +++RE R +VIEMV+ATDMS HF Q++ MK  +  PE++ K   LS +LH+ADISHP K W++HH+WT  ++EEFFRQGD E E GL  SPLCDR ST++ +SQ+GFI+FIVEP F VL D+ + I     DET
Sbjct:  104 LRSLVKQLERGEASVVDLKKNLEYAATVLESVYIDETRRLLDTEDELSDIQSDAVPSEVRDWLASTFTRQMGMMLRRSDEKPRFKSIVHAVQAGIFVERMYRRTSNMVGLSYPPAVIDALKD-VDTWSFDVFSLNEASGDHALKFIFYELLTRYDLISRFKIPISALVSFVEALEVGYSKHKNPYHNLMHAADVTQTVHYLLYKTGVANWLTELEIFAIIFSAAIHDYEHTGTTNNFHIQTRSDPAILYNDRSVLENHHLSAAYRLLQEDEEMNILVNLSKDDWREFRTLVIEMVMATDMSCHFQQIKAMKTALQQPEAIEKPKALSLMLHTADISHPAKAWDLHHRWTMSLLEEFFRQGDREAELGLPFSPLCDRKSTMVAQSQVGFIDFIVEPTFTVLTDMTEKIVSPLIDET 517
[Close]
BLAST of Phosphodiesterase vs. UniProt/SwissProt
Match: sp|P14100|PDE1A_BOVIN (Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A OS=Bos taurus OX=9913 GN=PDE1A PE=1 SV=3)

HSP 1 Score: 387.497 bits (994), Expect = 1.392e-128
Identity = 182/425 (42.82%), Postives = 284/425 (66.82%), Query Frame = 3 
Query:  105 LKLCLSQLENGEINRIVLINNLQDTSQFLDKAFLNS----LSKDEDIFSETDSELPENVQEWISSTFTKRQ---KVSPPPRQRLRSLINAVRVGMYFDRAFRKVSLPGSISAPPNAMIYLKQHINNWTFDIFHFNNLANNHSLKIMGYELLHSNQLISRFSIDINVLEAFLDKLEEGYSLHQNPYHNLIHAADVAHTCFLIVSKSRLFNWLSDLELFSILISALIHDFEHTGTSNNYHVNLNSNLALIYNDRSVLENHHLSAAFRLMKDDRYNIVQSLNANEYRELRNMVIEMVLATDMSAHFNQVQVMKEGVLLPESLRKINILSYVLHSADISHPCKPWEMHHQWTNMVVEEFFRQGDNEKEFGLTCSPLCDRDSTLIPESQIGFINFIVEPCFLVLGDIQKAISILCPDETLLSDDPSENST 1358
            L+  + QLE G++N I L  N++  +  L+  +++     L  D+++       +P  V++W++STFT++    K     + R RS+++ V+ G++ +R +RK      ++ P   ++ LK  ++ W+FD+F  N  +  HSLK M YEL     LI+RF I ++ L AF + LE GYS ++NPYHNLIHAADV  T   I+  + + +WL++LE+ +++ +A IHD+EHTGT+NN+H+   S++A++YNDRSVLENHH+SAA+RLM+++  N++ +L+ +++R+LRN+VIEMVL+TDMS HF Q++ ++  +  PE L K   +S +LH+ADISHP K W++HH+WT  ++EEFF QGD E E GL  SPLCDR ST++ +SQIGFI+FIVEP F +L D  + I I   +E   +  PS  ++
Sbjct:   35 LRCLVKQLEKGDVNVIDLKKNIEYAASVLEAVYIDETRRLLDTDDELSDIQSDSVPSEVRDWLASTFTRKMGMMKKKSEEKPRFRSIVHVVQAGIFVERMYRKSYHMVGLAYPEAVIVTLKD-VDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLIAFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNVLINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGLDKAKTMSLILHAADISHPAKSWKLHHRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIIIPLIEEDSKTKTPSYGAS 458
[Close]
BLAST of Phosphodiesterase vs. UniProt/SwissProt
Match: sp|Q61481|PDE1A_MOUSE (Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A OS=Mus musculus OX=10090 GN=Pde1a PE=1 SV=3)

HSP 1 Score: 381.333 bits (978), Expect = 5.540e-126
Identity = 181/415 (43.61%), Postives = 283/415 (68.19%), Query Frame = 3 
Query:  105 LKLCLSQLENGEINRIVLINNLQDTSQFLDKAFLNSLSK---DEDIFS--ETDSELPENVQEWISSTFTKRQKVSPPPRQR---LRSLINAVRVGMYFDRAFRKVSLPGSISAPPNAMIYLKQHINNWTFDIFHFNNLANNHSLKIMGYELLHSNQLISRFSIDINVLEAFLDKLEEGYSLHQNPYHNLIHAADVAHTCFLIVSKSRLFNWLSDLELFSILISALIHDFEHTGTSNNYHVNLNSNLALIYNDRSVLENHHLSAAFRLMKDDRYNIVQSLNANEYRELRNMVIEMVLATDMSAHFNQVQVMKEGVLLPESLRKINILSYVLHSADISHPCKPWEMHHQWTNMVVEEFFRQGDNEKEFGLTCSPLCDRDSTLIPESQIGFINFIVEPCFLVLGDIQKAISILCPDET 1325
            L+  + QLE G++N + L  N++  +  L+  +++   +    ED  S  +TDS +P  V++W++STFT++  +     +     RS+++AV+ G++ +R +RK      ++ P   ++ LK+ ++ W+FD+F  N  +  HSLK M YEL     LI+RF I ++ L AF + LE GYS H+NPYHNL+HAADV  T   I+  + + +WL++LE+ +++ +A IHD+EHTGT+NN+H+   S++A++YNDRSVLENHH+SAA+RLM+++  NI+ +L+ +++R+LRN+VIEMVLATDMS HF Q++ ++  +  PE + +   +S +LH+ADISHP K W++H++WT  ++EEFF QGD E E GL  SPLCDR ST++ +SQIGFI+FIVEP F +L D  + I I   +E 
Sbjct:   35 LRCLVKQLEKGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDS-VPSEVRDWLASTFTRKMGMMKKKPEEKPKFRSIVHAVQAGIFVERMYRKNYHMVGLTYPAAVIVTLKE-VDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLIAFAEALEVGYSKHKNPYHNLVHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILVNLSKDDWRDLRNLVIEMVLATDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKTWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEA 447
[Close]
BLAST of Phosphodiesterase vs. TrEMBL
Match: A0A267EIK0 (Phosphodiesterase OS=Macrostomum lignano OX=282301 GN=BOX15_Mlig011124g2 PE=3 SV=1)

HSP 1 Score: 448.358 bits (1152), Expect = 1.581e-146
Identity = 214/463 (46.22%), Postives = 315/463 (68.03%), Query Frame = 3 
Query:   90 TLSENLKLCLSQLENGEINRIVLINNLQDTSQFLDKAFLNSLSK----DEDIFSETDSELPENVQEWISSTFTKRQKVSPPPRQ--RLRSLINAVRVGMYFDRAFRKVSLPGSISAPPNAMIYLKQHINNWTFDIFHFNNLANNHSLKIMGYELLHSNQLISRFSIDINVLEAFLDKLEEGYSLHQNPYHNLIHAADVAHTCFLIVSKSRLFNWLSDLELFSILISALIHDFEHTGTSNNYHVNLNSNLALIYNDRSVLENHHLSAAFRLMKDDRYNIVQSLNANEYRELRNMVIEMVLATDMSAHFNQVQVMKEGVLLPESLRKINILSYVLHSADISHPCKPWEMHHQWTNMVVEEFFRQGDNEKEFGLTCSPLCDRDSTLIPESQIGFINFIVEPCFLVLGD-IQKAISILCPDETLLSDDPSENSTVNGEKQIQT-----------PWMDNLGNNKVKW 1424
            T S  LK     +E+ EI++ +LI NL    + L+  +++   +    D+D+     +E+P  V++W++STFT+ Q      R+  R RS+ NA+R G+  +R +R++S   +IS PPN +I LK  +++W FDIF  N  ++NH++K +GYELLH   LI++F I+ NVLE FL KLEEGYS   NPYHNL+H ADVA TC  I+S S+L NWL+DLE+F+ +++AL+HD+EHTGT+N++HVN  S+LAL+YND+ VLEN+H+SA FRL++++ YNI+  L+  EY+E R +VI+MVL TDMS HF Q++ MK+ + +PE++ K   L+ +LH ADISHP K W +HH+WT  ++EEFFRQGD EK   L CSPLCDR ST++ +SQ+GFI+FI+EP F VLGD ++K ++ L   +  LS +PSE +     + ++            PW D +  N+ +W
Sbjct:  257 TCSVRLKKIAKLVESDEISKEMLIKNLNYAVKVLESVYVDETRRLCNEDDDLPEVPPNEVPNEVRDWLASTFTRSQTSLKQSREKPRFRSVANAIRAGIMVERIYRRLSSSSNISVPPNVLILLKAGLDDWCFDIFELNEASDNHAMKFVGYELLHKYDLITKFKINTNVLENFLYKLEEGYSKWANPYHNLVHGADVAQTCHFIMSSSKLVNWLTDLEIFATIVAALVHDYEHTGTTNSFHVNTGSDLALLYNDKGVLENYHVSAVFRLLREEDYNILTGLSREEYKEFRALVIDMVLNTDMSLHFQQIKNMKQLLSMPENIDKEKALALMLHCADISHPGKRWNLHHRWTMSLLEEFFRQGDREKALDLPCSPLCDRSSTMVAQSQVGFIDFIMEPSFAVLGDMLEKILTPLFEQQKQLSKNPSEEAGARISRPVRKWHGDGGFCLPRPWNDIIKENRSQW 719
[Close]
BLAST of Phosphodiesterase vs. TrEMBL
Match: A0A267EML7 (Phosphodiesterase OS=Macrostomum lignano OX=282301 GN=BOX15_Mlig011124g1 PE=3 SV=1)

HSP 1 Score: 447.973 bits (1151), Expect = 2.567e-146
Identity = 214/463 (46.22%), Postives = 315/463 (68.03%), Query Frame = 3 
Query:   90 TLSENLKLCLSQLENGEINRIVLINNLQDTSQFLDKAFLNSLSK----DEDIFSETDSELPENVQEWISSTFTKRQKVSPPPRQ--RLRSLINAVRVGMYFDRAFRKVSLPGSISAPPNAMIYLKQHINNWTFDIFHFNNLANNHSLKIMGYELLHSNQLISRFSIDINVLEAFLDKLEEGYSLHQNPYHNLIHAADVAHTCFLIVSKSRLFNWLSDLELFSILISALIHDFEHTGTSNNYHVNLNSNLALIYNDRSVLENHHLSAAFRLMKDDRYNIVQSLNANEYRELRNMVIEMVLATDMSAHFNQVQVMKEGVLLPESLRKINILSYVLHSADISHPCKPWEMHHQWTNMVVEEFFRQGDNEKEFGLTCSPLCDRDSTLIPESQIGFINFIVEPCFLVLGD-IQKAISILCPDETLLSDDPSENSTVNGEKQIQT-----------PWMDNLGNNKVKW 1424
            T S  LK     +E+ EI++ +LI NL    + L+  +++   +    D+D+     +E+P  V++W++STFT+ Q      R+  R RS+ NA+R G+  +R +R++S   +IS PPN +I LK  +++W FDIF  N  ++NH++K +GYELLH   LI++F I+ NVLE FL KLEEGYS   NPYHNL+H ADVA TC  I+S S+L NWL+DLE+F+ +++AL+HD+EHTGT+N++HVN  S+LAL+YND+ VLEN+H+SA FRL++++ YNI+  L+  EY+E R +VI+MVL TDMS HF Q++ MK+ + +PE++ K   L+ +LH ADISHP K W +HH+WT  ++EEFFRQGD EK   L CSPLCDR ST++ +SQ+GFI+FI+EP F VLGD ++K ++ L   +  LS +PSE +     + ++            PW D +  N+ +W
Sbjct:  257 TCSVRLKKIAKLVESDEISKEMLIKNLNYAVKVLESVYVDETRRLCNEDDDLPEVPPNEVPNEVRDWLASTFTRSQTSLKQSREKPRFRSVANAIRAGIMVERIYRRLSSSSNISVPPNVLILLKAGLDDWCFDIFELNEASDNHAMKFVGYELLHKYDLINKFKINTNVLENFLYKLEEGYSKWANPYHNLVHGADVAQTCHFIMSSSKLVNWLTDLEIFATIVAALVHDYEHTGTTNSFHVNTGSDLALLYNDKGVLENYHVSAVFRLLREEDYNILTGLSREEYKEFRALVIDMVLNTDMSLHFQQIKNMKQLLSMPENIDKEKALALMLHCADISHPGKRWNLHHRWTMSLLEEFFRQGDREKALDLPCSPLCDRSSTMVAQSQVGFIDFIMEPSFAVLGDMLEKILTPLFEQQKQLSKNPSEEAGARISRPVRKWHGDGGFCLPRPWNDIIKENRSQW 719
[Close]
BLAST of Phosphodiesterase vs. TrEMBL
Match: A0A267DMF6 (Phosphodiesterase OS=Macrostomum lignano OX=282301 GN=BOX15_Mlig013692g1 PE=3 SV=1)

HSP 1 Score: 426.402 bits (1095), Expect = 3.464e-141
Identity = 213/472 (45.13%), Postives = 311/472 (65.89%), Query Frame = 3 
Query:   96 SENLKLCLSQLENGEINRIVLINNLQDTSQFLDKAFLNSLSK----DEDIFSETDSELPENVQEWISSTFTKRQKVSPPPRQR--LRSLINAVRVGMYFDRAFRKVSLPGSISAPPNAMIYLKQHINNWTFDIFHFNNLANNHSLKIMGYELLHSNQLISRFSIDINVLEAFLDKLEEGYSLHQNPYHNLIHAADVAHTCFLIVSKSRLFNWLSDLELFSILISALIHDFEHTGTSNNYHVNLNSNLALIYNDRSVLENHHLSAAFRLMKDDRYNIVQSLNANEYRELRNMVIEMVLATDMSAHFNQVQVMKEGVLLPESLRKINILSYVLHSADISHPCKPWEMHHQWTNMVVEEFFRQGDNEKEFGLTCSPLCDRDSTLIPESQIGFINFIVEPCFLVLGDI------------QKAISILCPDETLLSDDPSENSTVNGEKQIQTPWMDNLGNNKVKWAQLIKTKKEID 1457
            S  LK     +E   IN+ +L+ NL+   Q L+  + +   +    D+D+   + +E+P  V++W++STFT+ Q      +++   RS+ NA+R G+  +R +R++S   SIS PPN ++ LK  ++ W FD+F  N ++ NH++K +G+ELLH   LIS+F I+ +VLE FL K EEGYS   NPYHNL+H ADVA TC  I+  S+L NWL+DLE+F+ +I+ALIHD+EHTGT+NN+H+N+NS+LAL+YND+ VLEN+H+SA F LM++D YNI+  L   EY+E R +VI+MVL TDMS HF Q++ MK+ + +PE + K   L+ +LH ADISHP K W++H++WT  ++EEFFRQGD E+   L CSPLCDR  T++ +SQ+GFI+FI+EP F VLGD+            +KA     PD     DD S  ++ +G   I+ PW D +  N+  W    K + EI+
Sbjct:   53 SVRLKKIARLVEEDTINKELLVQNLRYAVQVLEAVYEDETKRLCNEDDDLPEVSPNEVPSEVRDWLASTFTRSQTSLKQNKEKPHFRSVANAIRAGIMVERIYRRLSSSSSISVPPNVLLLLKAGLDEWCFDVFELNEVSENHAMKFVGFELLHKYDLISKFKINSSVLENFLYKCEEGYSKWGNPYHNLVHGADVAQTCHFIMHDSKLVNWLTDLEIFATIIAALIHDYEHTGTTNNFHINMNSDLALLYNDKGVLENYHVSAIFTLMREDDYNILTGLTREEYKEFRALVIDMVLNTDMSLHFQQIKNMKQLLSMPEKIDKEKALALMLHCADISHPGKRWDLHYRWTLGLLEEFFRQGDRERALDLPCSPLCDRTVTMVAQSQVGFIDFIMEPSFNVLGDMLEKILGPLFEQQRKAGGSAGPD-----DDGS--ASESGSPSIRRPWADVIKENRATW----KARAEIE 513
[Close]
BLAST of Phosphodiesterase vs. TrEMBL
Match: A0A267DMU5 (Phosphodiesterase OS=Macrostomum lignano OX=282301 GN=BOX15_Mlig013692g2 PE=3 SV=1)

HSP 1 Score: 425.631 bits (1093), Expect = 1.328e-139
Identity = 213/472 (45.13%), Postives = 310/472 (65.68%), Query Frame = 3 
Query:   96 SENLKLCLSQLENGEINRIVLINNLQDTSQFLDKAFLNSLSK----DEDIFSETDSELPENVQEWISSTFTKRQKVSPPPRQR--LRSLINAVRVGMYFDRAFRKVSLPGSISAPPNAMIYLKQHINNWTFDIFHFNNLANNHSLKIMGYELLHSNQLISRFSIDINVLEAFLDKLEEGYSLHQNPYHNLIHAADVAHTCFLIVSKSRLFNWLSDLELFSILISALIHDFEHTGTSNNYHVNLNSNLALIYNDRSVLENHHLSAAFRLMKDDRYNIVQSLNANEYRELRNMVIEMVLATDMSAHFNQVQVMKEGVLLPESLRKINILSYVLHSADISHPCKPWEMHHQWTNMVVEEFFRQGDNEKEFGLTCSPLCDRDSTLIPESQIGFINFIVEPCFLVLGDI------------QKAISILCPDETLLSDDPSENSTVNGEKQIQTPWMDNLGNNKVKWAQLIKTKKEID 1457
            S  LK     +E   IN+ +L+ NL+   Q L+  + +   +    D+D+   + +E+P  V++W++STFT+ Q      +++   RS+ NA+R G+  +R +R++S   SIS PPN ++ LK  ++ W FD+F  N ++ NH++K +G+ELLH   LIS+F I+ +VLE FL K EEGYS   NPYHNL+H ADVA TC  I+  S+L NWL+DLE+F+ +I+ALIHD+EHTGT+NN+H+N NS+LAL+YND+ VLEN+H+SA F LM++D YNI+  L   EY+E R +VI+MVL TDMS HF Q++ MK+ + +PE + K   L+ +LH ADISHP K W++H++WT  ++EEFFRQGD E+   L CSPLCDR  T++ +SQ+GFI+FI+EP F VLGD+            +KA     PD     DD S  ++ +G   I+ PW D +  N+  W    K + EI+
Sbjct:  156 SVRLKKIARLVEEDTINKELLVQNLRYAVQVLEAVYEDETKRLCNEDDDLPEVSPNEVPSEVRDWLASTFTRSQTSLKQNKEKPHFRSVANAIRAGIMVERIYRRLSSSSSISVPPNVLLLLKAGLDEWCFDVFELNEVSENHAMKFVGFELLHKYDLISKFKINSSVLENFLYKCEEGYSKWGNPYHNLVHGADVAQTCHFIMHDSKLVNWLTDLEIFATIIAALIHDYEHTGTTNNFHINTNSDLALLYNDKGVLENYHVSAIFTLMREDDYNILTGLTREEYKEFRALVIDMVLNTDMSLHFQQIKNMKQLLSMPEKIDKEKALALMLHCADISHPGKRWDLHYRWTLGLLEEFFRQGDRERALDLPCSPLCDRTVTMVAQSQVGFIDFIMEPSFNVLGDMLEKILGPLFEQQRKAGGSAGPD-----DDGS--ASESGSPSIRRPWADVIKENRATW----KARAEIE 616
[Close]
BLAST of Phosphodiesterase vs. TrEMBL
Match: A0A4S2MDP0 (Phosphodiesterase OS=Opisthorchis felineus OX=147828 GN=CRM22_000801 PE=3 SV=1)

HSP 1 Score: 421.009 bits (1081), Expect = 3.301e-138
Identity = 203/464 (43.75%), Postives = 298/464 (64.22%), Query Frame = 3 
Query:   87 RTLSENLKLCLSQLENGEINRIVLINNLQDTSQFLDKAFLNSLSKDEDI---FSETDSE-LPENVQEWISSTFTKRQKVSPPPRQ--RLRSLINAVRVGMYFDRAFRKVSLPGSISAPPNAMIYLKQHINNWTFDIFHFNNLANNHSLKIMGYELLHSNQLISRFSIDINVLEAFLDKLEEGYSLHQNPYHNLIHAADVAHTCFLIVSKSRLFNWLSDLELFSILISALIHDFEHTGTSNNYHVNLNSNLALIYNDRSVLENHHLSAAFRLMKDDRYNIVQSLNANEYRELRNMVIEMVLATDMSAHFNQVQVMKEGVLLPESLRKINILSYVLHSADISHPCKPWEMHHQWTNMVVEEFFRQGDNEKEFGLTCSPLCDRDSTLIPESQIGFINFIVEPCFLVLGD-IQKAISILCPDETLLSDD---PSENSTVNGEKQIQTPWMDNLGNNKVKWAQLIKTKK 1448
            R     ++     +E   I +  L+ NL      ++  +++   +  +     SE  +E +P+ V++W++STFT+ Q VS    Q  R RS+ NA+R G++ +R +R++S   ++  PPN ++ LK  +++W+FD+F  N  + NH+LK + +ELLH   LI++F I  N LE+ L +LE GYS + NPYHNL+HAADV  TC +I+  + L NWL+DL+ F++L +A+IHD+EHTGT+NN+H++  S LA++YNDR VLENHH+SA FRLM+ D YNIV +L   +++E R MVI+MVL TDMS HF Q++ MK  + +PE + K   LS ++H ADI HP K W +H QWTNM+ EEFFRQGD EKE  L  SPLCDR++ ++P+SQ+GFI+FIVEP F VLGD I++ ++   P++    D    PS +        +  PW +    NK  WA L    K
Sbjct:  137 RACYVRMRQVYDAIEQDRIGKATLLKNLHYAIMVMESTYISERRRIREEEEDLSEAATEFVPDEVRDWLASTFTRTQAVSGIGNQKPRFRSVANAIRAGIFVERIYRRMSSCSNLLIPPNVLLMLKAGLDSWSFDVFALNEASENHALKFVAFELLHKYNLINKFQISTNALESLLVQLEVGYSKYSNPYHNLMHAADVMQTCHMIMHLNNLRNWLTDLDAFALLFAAVIHDYEHTGTTNNFHISTASELAIVYNDRGVLENHHVSAVFRLMQQDEYNIVNNLEQAQFKEFRQMVIDMVLCTDMSLHFQQIKNMKTMITMPEDVDKTKALSLIVHCADIGHPAKKWSLHEQWTNMLCEEFFRQGDREKELNLPISPLCDRNTVVVPQSQLGFIDFIVEPSFQVLGDMIERIVTPASPEDEKSLDPIKLPSSDDPTPPVPVVPRPWEECFDENKKAWAALTAEAK 600
[Close]
BLAST of Phosphodiesterase vs. Ensembl Cavefish
Match: PDE1C (phosphodiesterase 1C [Source:NCBI gene;Acc:103040750])

HSP 1 Score: 405.216 bits (1040), Expect = 3.850e-136
Identity = 205/471 (43.52%), Postives = 306/471 (64.97%), Query Frame = 3 
Query:   96 SENLKLCLSQLENGEINRIVLINNLQDTSQFLDKAFL---NSLSKDEDIFSETDSE-LPENVQEWISSTFTKRQKV---SPPPRQRLRSLINAVRVGMYFDRAFRKVSLPGSISAPPNAMIYLKQHINNWTFDIFHFNNLANNHSLKIMGYELLHSNQLISRFSIDINVLEAFLDKLEEGYSLHQNPYHNLIHAADVAHTCFLIVSKSRLFNWLSDLELFSILISALIHDFEHTGTSNNYHVNLNSNLALIYNDRSVLENHHLSAAFRLMK-DDRYNIVQSLNANEYRELRNMVIEMVLATDMSAHFNQVQVMKEGVLLPESLRKINILSYVLHSADISHPCKPWEMHHQWTNMVVEEFFRQGDNEKEFGLTCSPLCDRDSTLIPESQIGFINFIVEPCFLVLGDIQKAISILCPDE-----------TLLSDDPSENST---VNGEKQIQTPWMDNLGNNKVKW-AQLIK 1439
            SE L+  + QLE GE + + L  NL+  +  L+  ++     L   ED  S+  S+ +P  V++W++STFT++  +       + R RS+++AV+ G++ +R +R+ S    +S PP+ +  LK H++ W+FD+F  N  + +H+LK + YELL    LI+RF I I+ L +F++ LE GYS H+NPYHNLIHAADV  T   ++ KS + +WL++LE+F+++ +A +HD+EHTGT+NN+H+   S+ A++YNDR+V ENHH+SAA+RL++ DD  NI+ +L+ +++RELR +V+EMVLATDMS HF Q++ MK  +  PE++ K   LS +LH+ADISHP K W++HH WT  ++EEFFRQGD E + GL  SPLCDR ST++ +SQIGFI+FIVEP F VL D+ + I     DE           + +    SE ST       K  +  W D +  N+ KW AQ  K
Sbjct:   39 SEMLRCLVKQLERGEASVVDLKKNLEYAASVLESVYIEETRRLVDTEDELSDIQSDSVPSEVRDWLASTFTRQMGLMLRRSEEKPRFRSIVHAVQAGIFVERMYRRTSNMVGLSYPPSVITVLK-HVDTWSFDVFALNEASGDHALKFIFYELLTRYDLINRFKIPISALVSFVEALEVGYSKHKNPYHNLIHAADVTQTVHYLLLKSGMVHWLTELEIFAMIFAAAVHDYEHTGTTNNFHIQTRSDAAILYNDRAVQENHHVSAAYRLLQDDDEMNILYNLSKDDWRELRTLVVEMVLATDMSCHFQQIKAMKNFLQQPEAIDKPKALSLLLHTADISHPAKRWDLHHHWTTSLLEEFFRQGDKESDLGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFTVLTDMTEKIVTPLIDEASSSGLAGFRRSSVKSTGSEGSTSLLSVDFKSFKATWNDEVHQNREKWKAQAAK 508
[Close]
BLAST of Phosphodiesterase vs. Ensembl Cavefish
Match: PDE1C (phosphodiesterase 1C [Source:NCBI gene;Acc:103040750])

HSP 1 Score: 404.445 bits (1038), Expect = 1.120e-133
Identity = 199/447 (44.52%), Postives = 295/447 (66.00%), Query Frame = 3 
Query:    9 EILNKMLINVLGKDLMENKQISVQLARTLSENLKLCLSQLENGEINRIVLINNLQDTSQFLDKAFLNS---LSKDEDIFSETDSE-LPENVQEWISSTFTKRQKV---SPPPRQRLRSLINAVRVGMYFDRAFRKVSLPGSISAPPNAMIYLKQHINNWTFDIFHFNNLANNHSLKIMGYELLHSNQLISRFSIDINVLEAFLDKLEEGYSLHQNPYHNLIHAADVAHTCFLIVSKSRLFNWLSDLELFSILISALIHDFEHTGTSNNYHVNLNSNLALIYNDRSVLENHHLSAAFRLMK-DDRYNIVQSLNANEYRELRNMVIEMVLATDMSAHFNQVQVMKEGVLLPESLRKINILSYVLHSADISHPCKPWEMHHQWTNMVVEEFFRQGDNEKEFGLTCSPLCDRDSTLIPESQIGFINFIVEPCFLVLGDIQKAISILCPDET 1325
            EIL   L  V   D ME   I           L+  + QLE GE + + L  NL+  +  L+  ++     L   ED  S+  S+ +P  V++W++STFT++  +       + R RS+++AV+ G++ +R +R+ S    +S PP+ +  LK H++ W+FD+F  N  + +H+LK + YELL    LI+RF I I+ L +F++ LE GYS H+NPYHNLIHAADV  T   ++ KS + +WL++LE+F+++ +A +HD+EHTGT+NN+H+   S+ A++YNDR+V ENHH+SAA+RL++ DD  NI+ +L+ +++RELR +V+EMVLATDMS HF Q++ MK  +  PE++ K   LS +LH+ADISHP K W++HH WT  ++EEFFRQGD E + GL  SPLCDR ST++ +SQIGFI+FIVEP F VL D+ + I     DE 
Sbjct:   80 EILADELPAVDSPDAMEKTAI----------RLRCLVKQLERGEASVVDLKKNLEYAASVLESVYIEETRRLVDTEDELSDIQSDSVPSEVRDWLASTFTRQMGLMLRRSEEKPRFRSIVHAVQAGIFVERMYRRTSNMVGLSYPPSVITVLK-HVDTWSFDVFALNEASGDHALKFIFYELLTRYDLINRFKIPISALVSFVEALEVGYSKHKNPYHNLIHAADVTQTVHYLLLKSGMVHWLTELEIFAMIFAAAVHDYEHTGTTNNFHIQTRSDAAILYNDRAVQENHHVSAAYRLLQDDDEMNILYNLSKDDWRELRTLVVEMVLATDMSCHFQQIKAMKNFLQQPEAIDKPKALSLLLHTADISHPAKRWDLHHHWTTSLLEEFFRQGDKESDLGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFTVLTDMTEKIVTPLIDEA 515
[Close]
BLAST of Phosphodiesterase vs. Ensembl Cavefish
Match: PDE1C (phosphodiesterase 1C [Source:NCBI gene;Acc:103040750])

HSP 1 Score: 403.29 bits (1035), Expect = 1.818e-133
Identity = 191/421 (45.37%), Postives = 289/421 (68.65%), Query Frame = 3 
Query:   87 RTLSENLKLCLSQLENGEINRIVLINNLQDTSQFLDKAFLNS---LSKDEDIFSETDSE-LPENVQEWISSTFTKRQKV---SPPPRQRLRSLINAVRVGMYFDRAFRKVSLPGSISAPPNAMIYLKQHINNWTFDIFHFNNLANNHSLKIMGYELLHSNQLISRFSIDINVLEAFLDKLEEGYSLHQNPYHNLIHAADVAHTCFLIVSKSRLFNWLSDLELFSILISALIHDFEHTGTSNNYHVNLNSNLALIYNDRSVLENHHLSAAFRLMK-DDRYNIVQSLNANEYRELRNMVIEMVLATDMSAHFNQVQVMKEGVLLPESLRKINILSYVLHSADISHPCKPWEMHHQWTNMVVEEFFRQGDNEKEFGLTCSPLCDRDSTLIPESQIGFINFIVEPCFLVLGDIQKAISILCPDET 1325
            +  S+ L+  + QLE GE + + L  NL+  +  L+  ++     L   ED  S+  S+ +P  V++W++STFT++  +       + R RS+++AV+ G++ +R +R+ S    +S PP+ +  LK H++ W+FD+F  N  + +H+LK + YELL    LI+RF I I+ L +F++ LE GYS H+NPYHNLIHAADV  T   ++ KS + +WL++LE+F+++ +A +HD+EHTGT+NN+H+   S+ A++YNDR+V ENHH+SAA+RL++ DD  NI+ +L+ +++RELR +V+EMVLATDMS HF Q++ MK  +  PE++ K   LS +LH+ADISHP K W++HH WT  ++EEFFRQGD E + GL  SPLCDR ST++ +SQIGFI+FIVEP F VL D+ + I     DE 
Sbjct:   48 KKTSQRLRCLVKQLERGEASVVDLKKNLEYAASVLESVYIEETRRLVDTEDELSDIQSDSVPSEVRDWLASTFTRQMGLMLRRSEEKPRFRSIVHAVQAGIFVERMYRRTSNMVGLSYPPSVITVLK-HVDTWSFDVFALNEASGDHALKFIFYELLTRYDLINRFKIPISALVSFVEALEVGYSKHKNPYHNLIHAADVTQTVHYLLLKSGMVHWLTELEIFAMIFAAAVHDYEHTGTTNNFHIQTRSDAAILYNDRAVQENHHVSAAYRLLQDDDEMNILYNLSKDDWRELRTLVVEMVLATDMSCHFQQIKAMKNFLQQPEAIDKPKALSLLLHTADISHPAKRWDLHHHWTTSLLEEFFRQGDKESDLGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFTVLTDMTEKIVTPLIDEA 467
[Close]
BLAST of Phosphodiesterase vs. Ensembl Cavefish
Match: PDE1C (phosphodiesterase 1C [Source:NCBI gene;Acc:103040750])

HSP 1 Score: 404.445 bits (1038), Expect = 2.102e-133
Identity = 212/512 (41.41%), Postives = 313/512 (61.13%), Query Frame = 3 
Query:    9 EILNKMLINVLGKDLMENKQISVQLARTLSENLKLCLSQLENGEINRIVLINNLQDTSQFLDKAFLNSLSK---DEDIFSETDSE-LPENVQEWISSTFTKRQKV---SPPPRQRLRSLINAVRVGMYFDRAFRKVSLPGSISAPPNAMIYLKQHINNWTFDIFHFNNLANNHSLKIMGYELLHSNQLISRFSIDINVLEAFLDKLEEGYSLHQNPYHNLIHAADVAHTCFLIVSKSRLFNWLSDLELFSILISALIHDFEHTGTSNNYHVNLNSNLALIYNDRSVLENHHLSAAFRLMK-DDRYNIVQSLNANEYRELRNMVIEMVLATDMSAHFNQVQVMKEGVLLPESLRKINILSYVLHSADISHPCKPWEMHHQWTNMVVEEFFRQGDNEKEFGLTCSPLCDRDSTLIPESQIGFINFIVEPCFLVLGDIQKAISILCPDETLLSD-----------------DPSENSTVNGE---------KQIQTPWMDNLGNNKVKW-AQLIK 1439
            EIL   L  V   D ME   I           L+  + QLE GE + + L  NL+  +  L+  ++    +    ED  S+  S+ +P  V++W++STFT++  +       + R RS+++AV+ G++ +R +R+ S    +S PP+ +  LK H++ W+FD+F  N  + +H+LK + YELL    LI+RF I I+ L +F++ LE GYS H+NPYHNLIHAADV  T   ++ KS + +WL++LE+F+++ +A +HD+EHTGT+NN+H+   S+ A++YNDR+V ENHH+SAA+RL++ DD  NI+ +L+ +++RELR +V+EMVLATDMS HF Q++ MK  +  PE++ K   LS +LH+ADISHP K W++HH WT  ++EEFFRQGD E + GL  SPLCDR ST++ +SQIGFI+FIVEP F VL D+ + I     DE   S                   PS  ST +           K  +  W D +  N+ KW AQ  K
Sbjct:   80 EILADELPAVDSPDAMEKTAI----------RLRCLVKQLERGEASVVDLKKNLEYAASVLESVYIEETRRLVDTEDELSDIQSDSVPSEVRDWLASTFTRQMGLMLRRSEEKPRFRSIVHAVQAGIFVERMYRRTSNMVGLSYPPSVITVLK-HVDTWSFDVFALNEASGDHALKFIFYELLTRYDLINRFKIPISALVSFVEALEVGYSKHKNPYHNLIHAADVTQTVHYLLLKSGMVHWLTELEIFAMIFAAAVHDYEHTGTTNNFHIQTRSDAAILYNDRAVQENHHVSAAYRLLQDDDEMNILYNLSKDDWRELRTLVVEMVLATDMSCHFQQIKAMKNFLQQPEAIDKPKALSLLLHTADISHPAKRWDLHHHWTTSLLEEFFRQGDKESDLGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFTVLTDMTEKIVTPLIDEASSSGLAGFRRSSLNNIPADGKRPSVKSTGSEGSTSLLSVDFKSFKATWNDEVHQNREKWKAQAAK 580
[Close]
BLAST of Phosphodiesterase vs. Ensembl Cavefish
Match: ENSAMXT00000048550.1 (pep primary_assembly:Astyanax_mexicanus-2.0:17:4377033:4466642:1 gene:ENSAMXG00000041175.1 transcript:ENSAMXT00000048550.1 gene_biotype:protein_coding transcript_biotype:protein_coding)

HSP 1 Score: 378.637 bits (971), Expect = 2.920e-125
Identity = 188/415 (45.30%), Postives = 279/415 (67.23%), Query Frame = 3 
Query:  114 CLSQLENGEINRIVL----INNLQDTSQFLDKAFLNSLSKDEDIFSETDSE-LPENVQEWISSTFTKR-----QKVSPPPRQRLRSLINAVRVGMYFDRAFRKVSLPGSISAPPNAMIYLKQHINNWTFDIFHFNNLANNHSLKIMGYELLHSNQLISRFSIDINVLEAFLDKLEEGYSLHQNPYHNLIHAADVAHTCFLIVSKSRLFNWLSDLELFSILISALIHDFEHTGTSNNYHVNLNSNLALIYNDRSVLENHHLSAAFRLMK-DDRYNIVQSLNANEYRELRNMVIEMVLATDMSAHFNQVQVMKEGVLLPESLRKINILSYVLHSADISHPCKPWEMHHQWTNMVVEEFFRQGDNEKEFGLTCSPLCDRDSTLIPESQIGFINFIVEPCFLVLGDIQKAISILCPDET 1325
             L  L+  +I +I L    +   + TSQ         L   ED  S+  S+ +P  V++W++STFT++     +K    PR   RS+++AV+ G++ +R +R+ S    +S P + +  LK H++ W+FD+F  N+ + +H+LK + YELL    LISRF I I+ L +F++ LE GYS H+NPYHNL+HAADV  T   ++ K+ + +WL++LE+F+++ +A +HD+EHTGT+NN+H+   S+ A++YNDRSVLE+HH+SAA+RL++ DD  NI+ +L+ +++RE R +V+EMVLATDMS HF QV+ MK  +  PE + K   LS +LH+ADISHP K W++HH+WT  ++EEFF QGD E E GL  SPLCDR ST++ +SQIGFI+FIV P F VL D+ + I     DE 
Sbjct:   15 SLKYLQPDQIEKIWLRLRGLRKYKKTSQ-------RRLVDTEDELSDIQSDSVPSEVRDWLASTFTRQMGLMLRKTEEKPR--FRSIVHAVQAGIFVERMYRRTSNMVGLSYPASVITVLK-HVDKWSFDVFALNDASGDHALKFIFYELLTRYDLISRFKIPISSLVSFVEALEVGYSKHKNPYHNLMHAADVTQTVHYLLLKTGMVHWLTELEIFAMIFAAAVHDYEHTGTTNNFHIQTRSDTAILYNDRSVLESHHVSAAYRLLQDDDEMNILYNLSKDDWREFRALVVEMVLATDMSCHFQQVKAMKNFLQQPEGIDKSKALSLLLHTADISHPAKNWDLHHRWTASLLEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVVPTFTVLTDMTEKIVTPLIDEA 419
[Close]
BLAST of Phosphodiesterase vs. Ensembl Sea Lamprey
Match: pde1a (phosphodiesterase 1A, calmodulin-dependent [Source:ZFIN;Acc:ZDB-GENE-090831-2])

HSP 1 Score: 402.519 bits (1033), Expect = 3.710e-136
Identity = 198/475 (41.68%), Postives = 301/475 (63.37%), Query Frame = 3 
Query:  102 NLKLCLSQLENGEINRIVLINNLQDTSQFLDKAFLNSLSK---DEDIFSETDSE-LPENVQEWISSTFTKRQKVS---PPPRQRLRSLINAVRVGMYFDRAFRKVSLPGSISAPPNAMIYLKQ-HINNWTFDIFHFNNLANNHSLKIMGYELLHSNQLISRFSIDINVLEAFLDKLEEGYSLHQNPYHNLIHAADVAHTCFLIVSKSRLFNWLSDLELFSILISALIHDFEHTGTSNNYHVNLNSNLALIYNDRSVLENHHLSAAFRLMKDDRYNIVQSLNANEYRELRNMVIEMVLATDMSAHFNQVQVMKEGVLLPESLRKINILSYVLHSADISHPCKPWEMHHQWTNMVVEEFFRQGDNEKEFGLTCSPLCDRDSTLIPESQIGFINFIVEPCFLVLGDIQKAISILCPDETLLSDDP-----SENSTV---NGEK----------------QIQTPWMDNLGNNKVKWAQ 1430
             L+  + QLE GEI    L  N++  +  L+  +++   +    ED   +  SE +P  V++W++STFT+R  V+   P  + R RS+++AV+ G++ +R +R+ S    +S PPN ++ LK    + W+FD+F  N  +  H+LK + +ELL   +LISR+ I +  L +F++ LE GYS H+NPYHNL HAADV  T   ++ +S L +WLS+LE  +++ +A IHD EHTGT+NN+H+   S++AL+YNDR+VLENHH+SAA+RLM+DD  NI  +L+ +++RELR +V+EMVLATDMS HF Q++ MK  +  PES+ K   +S +LH+ DISHP K W +H +WT  ++EEFFRQGD E + GL  SPLCDR+ST++ +SQIGF++FIVEP F VL D+ + + +   +E   +  P        +TV    G++                Q +  W + L +NK +W +
Sbjct:   25 RLRCLVKQLEKGEIPVAELRRNIEYAASVLEALYIDETRRLLDSEDELGDISSEAVPAEVRDWLASTFTRRMGVTARRPEDKPRFRSIVHAVQAGIFVERMYRRTSNMVGLSYPPNVLVALKNWTCHKWSFDVFVLNEASGEHALKFVMHELLTRYELISRYKIPVAALVSFVEALEAGYSKHKNPYHNLAHAADVTQTVHYLLLQSGLMHWLSELETLAVIFAAAIHDLEHTGTTNNFHIQTRSDVALLYNDRAVLENHHVSAAYRLMQDDDMNIFINLSKDDWRELRALVVEMVLATDMSCHFQQIKTMKSALQQPESIDKSKAMSLLLHAGDISHPTKEWPLHQRWTEALMEEFFRQGDREAKLGLPFSPLCDRNSTMVAQSQIGFMDFIVEPTFSVLTDMAEKVVVPLAEEAARAGTPGVPRRGSAATVEWHRGKRAASDGSVTSICTVDLLQFRALWQNCLSSNKERWKE 499
[Close]
BLAST of Phosphodiesterase vs. Ensembl Sea Lamprey
Match: PDE1C (phosphodiesterase 1C [Source:HGNC Symbol;Acc:HGNC:8776])

HSP 1 Score: 376.711 bits (966), Expect = 4.133e-127
Identity = 179/416 (43.03%), Postives = 283/416 (68.03%), Query Frame = 3 
Query:  102 NLKLCLSQLENGEINRIVLINNLQDTSQFLDKAFLNSLSK---DEDIFSETDSE-LPENVQEWISSTFTKRQKV---SPPPRQRLRSLINAVRVGMYFDRAFRKVSLPGSISAPPNAMIYLKQHINNWTFDIFHFNNLANNHSLKIMGYELLHSNQLISRFSIDINVLEAFLDKLEEGYSLHQNPYHNLIHAADVAHTCFLIVSKSRLFNWLSDLELFSILISALIHDFEHTGTSNNYHVNLNSNLALIYNDRSVLENHHLSAAFRLMK-DDRYNIVQSLNANEYRELRNMVIEMVLATDMSAHFNQVQVMKEGVLLPESLRKINILSYVLHSADISHPCKPWEMHHQWTNMVVEEFFRQGDNEKEFGLTCSPLCDRDSTLIPESQIGFINFIVEPCFLVLGDIQKAISILCPDET 1325
             L+  + QLE GE+  + L  NL+  +  L+  +++   +    ED  S+  S+ +P  V++W++STFT++  +       + R RS+++AV+ G++ +R +R+ S    +S PP  +  LK+ ++ W+FD+F  +  +  H+LK + YEL     LI+RF I ++ + +F++ LE GYS H+NPYHN +HAADV  T   ++ K+   +WL++LE+ S++ +A IHD+EHTGT+NN+H+   S+ A++YNDRSVLENHH+SAA+RLM+ D+  NI+ +L+ +++RELR +V+E VLATDMS HF+Q++ +K  +  PE + K   +S +LH+ADISHP K W +H +WT  ++EEFFRQGD E E GL+ SPLCDR++T++P+SQIGFI++IVEP F VL D+ + +     DE 
Sbjct:   18 RLRCLVKQLERGELPVLDLRKNLEYAASVLEAVYIDETRRLLDTEDELSDLRSDTVPSEVRDWLASTFTRQMGLMLKRSEEKPRFRSIVHAVQAGIFVERMYRRTSSMVGLSYPPAVISVLKE-VDKWSFDVFALHEASGEHALKFIVYELFTRYDLIARFKIPVSSVVSFVEALEAGYSKHKNPYHNSVHAADVTQTVHYLMLKTGTIHWLNELEILSMIFAAAIHDYEHTGTTNNFHIQTRSDSAILYNDRSVLENHHVSAAYRLMQEDEEMNILINLSKDDWRELRALVVETVLATDMSCHFHQLKSIKNLLQQPEGVEKPKAMSLMLHTADISHPAKNWNLHRRWTMSLMEEFFRQGDKEAELGLSFSPLCDRNATMVPQSQIGFIDYIVEPTFTVLTDLSEFVVAPLIDEA 432
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BLAST of Phosphodiesterase vs. Ensembl Sea Lamprey
Match: ENSPMAT00000003038.1 (pep scaffold:Pmarinus_7.0:GL476485:41:13228:1 gene:ENSPMAG00000002763.1 transcript:ENSPMAT00000003038.1 gene_biotype:protein_coding transcript_biotype:protein_coding)

HSP 1 Score: 192.586 bits (488), Expect = 2.787e-58
Identity = 88/186 (47.31%), Postives = 129/186 (69.35%), Query Frame = 3 
Query:  747 SALIHDFEHTGTSNNYHVNLNSNLALIYNDRSVLENHHLSAAFRLMK-DDRYNIVQSLNANEYRELRNMVIEMVLATDMSAHFNQVQVMKEGVLLPESLRKINILSYVLHSADISHPCKPWEMHHQWTNMVVEEFFRQGDNEKEFGLTCSPLCDRDSTLIPESQIGFINFIVEPCFLVLGDIQKAI 1301
            SA IHD EHTGT+NN+H+   S++A++YNDRSV+ENHH+S A+R+M+ D+  NI+ +L+  +YR     +I  VL    +  + Q+   K+    P  + K   +S ++H++DISHP K W +H +WT  ++EEFF+QGD E+E GL  SPLCDR ST++P+SQ+GFI+FIVEP   VL D+ + I
Sbjct:    1 SAAIHDLEHTGTTNNFHIQTRSDVAILYNDRSVMENHHVSTAYRIMQADEDANILINLSNRDYRIFLTQLINYVLMPIFNCAYKQLHFQKKIYKEPRVIDKPKAMSLIVHTSDISHPAKEWRLHRRWTESLLEEFFQQGDREEELGLPFSPLCDRKSTMVPQSQVGFIDFIVEPTLSVLTDMVEGI 186
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BLAST of Phosphodiesterase vs. Ensembl Sea Lamprey
Match: ENSPMAT00000007435.1 (pep scaffold:Pmarinus_7.0:GL486982:1709:8825:-1 gene:ENSPMAG00000006710.1 transcript:ENSPMAT00000007435.1 gene_biotype:protein_coding transcript_biotype:protein_coding)

HSP 1 Score: 172.17 bits (435), Expect = 3.414e-51
Identity = 85/192 (44.27%), Postives = 129/192 (67.19%), Query Frame = 3 
Query:  714 LSDLELFSILISALIHDFEHTGTSNNYHVNLNSNLALIYNDRSVLENHHLSAAFRLMKDDRYNIVQSLNANEYRELRNMVIEMVLATDMSAHFNQV----------QVMKEGVLLPESLR-KINILSYVLHSADISHPCKPWEMHHQWTNMVVEEFFRQGDNEKEFGLTCSPLCDRDSTLIPESQ-IGFINF 1253
             +DLE+ + + ++ IHD +H G SN + +N NS LAL+YND SVLENHHL+  F+L++++  +I Q+L+  + + LR MVI+MVLATDMS H N +          +V   GVLL ++   +I +L  ++H AD+S+P KP +++ QWT  ++EEFFRQGD E+E G+  SP+CD+ S  + +SQ I  I+F
Sbjct:    8 FTDLEILAAIFASAIHDVDHPGVSNQFLINTNSELALMYNDESVLENHHLAVGFKLLQEENCDIFQNLSKKQRQTLRKMVIDMVLATDMSKHMNLLADLKTMVETKKVTSSGVLLLDNYTDRIQVLQNMVHCADLSNPTKPLDVYRQWTERIMEEFFRQGDRERERGMEISPMCDKHSASVEKSQRINAIDF 199
[Close]
BLAST of Phosphodiesterase vs. Ensembl Sea Lamprey
Match: pde7a (phosphodiesterase 7A [Source:ZFIN;Acc:ZDB-GENE-031222-10])

HSP 1 Score: 169.859 bits (429), Expect = 1.179e-48
Identity = 95/277 (34.30%), Postives = 159/277 (57.40%), Query Frame = 3 
Query:  459 NWTFDIFHFNNLANNHSLKIMGYELLHSNQLISRFSIDINVLEAFLDKLEEGYSLHQNPYHNLIHAADVAHTCFLIVSKSRLFNWLSDLELFSILISALIHDFEHTGTSNNYHVNLNSNLALIYNDRSVLENHHLSAAFRLMKDDRYNIVQSLNANEYRELRNMVIEMVLATDMSAH---FNQVQ--VMKEGVLLPESLRKINILSYVLHSADISHPCKPWEMHHQWTNMVVEEFFRQGDNEKEFGLTCSPLCDRDSTLIPESQIGFINFIVEPCFL 1274
            +W+FD+F F+ L N +SL  +   L + + LI  F +D+  L  FL  ++E Y  +QNPYHN +HAADV       + + +L   L+  ++   L++A  HD +H G +  + +  + +LA +Y++ SVLENHH  +   ++++    +   L  +E  ++   +  ++LATD+S      +Q +  + K  + L E+  +  IL   L  ADI +PC+ W+   +W+  V EEFF+QGD E+++ L  SPLCDR +  +P  QIGF+ F+VEP F+
Sbjct:    7 SWSFDMFLFDRLTNGNSLVSLTCHLFNFHGLIQHFQLDMVKLRGFLVMVQEDYH-NQNPYHNAVHAADVTQAMHCYLREPKLAVHLTRRDIMLGLLAASAHDVDHPGVNQPFLIKTHHHLASLYHNSSVLENHHWRSTVGMLRES--GLFAHLPMDERLQMERDLGSLILATDISRQNEFLSQFKSHLDKGDLCLEEAPHRHFILQIALKCADICNPCRVWDTSKRWSEKVCEEFFKQGDMERKWRLEISPLCDRYTQTVPNIQIGFMTFVVEPLFM 280
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BLAST of Phosphodiesterase vs. Ensembl Yeast
Match: PDE2 (High-affinity cyclic AMP phosphodiesterase; component of the cAMP-dependent protein kinase signaling system, protects the cell from extracellular cAMP, contains readthrough motif surrounding termination codon [Source:SGD;Acc:S000005887])

HSP 1 Score: 61.2326 bits (147), Expect = 1.709e-10
Identity = 54/208 (25.96%), Postives = 103/208 (49.52%), Query Frame = 3 
Query:  549 LISRFSIDINVLEAFLDKLEEGYSL----HQ-NPYHNLIHAADVAHTCFLIVSKSRLFNWL---SDLELFSILISALIHDFEHTGTSNNYHVNLNSNLALIYNDRSVLENHHLSAAFRLMKDDRYNIVQSLNANEYRELRNMVIEMVLATDMSAHFNQVQVMKEGVLLPESLRKINILSYVLHSADISHPCKPWEMHHQWTNMVVEEF 1148
            LI + S D  VL A    L   ++L    HQ N +HN  HA DV    +      RL  +L   + ++   + ++A+ HD  H GT+N    N  S +A  + + S+LEN H    F+ +  + +  + S++  ++    + + E +LATDM+ H       ++ ++    +++I ++S ++ +ADIS+  +   +  +W  ++  EF
Sbjct:  230 LIKKLSKDAKVLIADNKLLLLLFTLESSYHQVNKFHNFRHAIDVMQATW------RLCTYLLKDNPVQTLLLCMAAIGHDVGHPGTNNQLLCNCESEVAQNFKNVSILENFH-RELFQQLLSEHWPQLLSISKKKF----DFISEAILATDMALH----SQYEDRLMHENPMKQITLISLIIKAADISNVTRTLSISARWAYLITLEF 422
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BLAST of Phosphodiesterase vs. Ensembl Nematostella
Match: EDO37301 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7SGA1])

HSP 1 Score: 330.872 bits (847), Expect = 3.590e-110
Identity = 160/360 (44.44%), Postives = 231/360 (64.17%), Query Frame = 3 
Query:  222 DEDIFSETDSELPENVQEWISSTFTK----RQKVSPPPRQRLRSLINAVRVGMYFDRAFRKVSLPGSISAPPNAMIYLKQHINNWTFDIFHFNNLANNHSLKIMGYELLHSNQLISRFSIDINVLEAFLDKLEEGYSLHQNPYHNLIHAADVAHTCFLIVSKSRLFNWLSDLELFSILISALIHDFEHTGTSNNYHVNLNSNLALIYNDRSVLENHHLSAAFRLMKDDRYNIVQSLNANEYRELRNMVIEMVLATDMSAHFNQVQVMKEGVLLPESLRKINILSYVLHSADISHPCKPWEMHHQWTNMVVEEFFRQGDNEKEFGLTCSPLCDRDSTLIPESQIGFINFIVEPCFLVLGDI 1289
            DE++ +E DS + E V+EWI++TF +     ++ S   R   R +++AV+  +Y ++  +  +    +  P N      Q    WTFD+F  +     H L+ +GYE+LH   ++  F I    L+ FL  +E GY  H NPYHN  HAADV HT    +    +  +LSDLE+F +L+SA+IHD EHTGT+N +H+N  S+LAL+YNDRSVLENHH+S AFR+++DD  NI+  LN  +Y ++R+++I+ VLATDMS+HF Q+++MK  ++    +    ++  +LH ADIS+P K W +H QWT  ++EEFF QGD E E GL  SPLCDR +TLIPESQIGFI+FIV P   V  ++
Sbjct:    3 DENLENELDS-VNEEVREWIATTFARGPGAARRKSMVRRHTFRGVVHAVKASLYVNKMLKNATERYKMHVPENV-----QKAFEWTFDVFALSESCEGHPLRYIGYEVLHRRDMLRNFKIHAMTLDRFLQDVETGYKRHSNPYHNDCHAADVTHTVHYFLECMGVSKYLSDLEVFGLLLSAIIHDLEHTGTTNAFHINSRSDLALLYNDRSVLENHHVSCAFRILQDDEKNILSGLNLEQYADVRSLMIDTVLATDMSSHFEQLRLMKVALVAGSPIENREVVQLLLHVADISNPTKDWTIHRQWTTKIMEEFFTQGDMEIELGLDVSPLCDRSTTLIPESQIGFIDFIVSPALEVCSEV 356
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BLAST of Phosphodiesterase vs. Ensembl Nematostella
Match: EDO46133 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7RQM4])

HSP 1 Score: 218.009 bits (554), Expect = 1.090e-64
Identity = 132/394 (33.50%), Postives = 214/394 (54.31%), Query Frame = 3 
Query:  195 KAFLNSLSKDEDIFSETDSELPENVQEWISSTFTKRQ-KVSPPP--------RQRLRSLINAVRVGMYFDRAFRKVSLPGSIS------APPNAMIYLKQHINNWTFDIFHFNNLANNHSLKIMGYELLHSNQLISRFSIDINVLEAFLDKLEEGYSLHQNPYHNLIHAADVAHTCFLIVSKSRLFNWLSDLELFSILISALIHDFEHTGTSNNYHVNLNSNLALIYNDRSVLENHHLSAAFRLMKDDRYNIVQSLNANEYRELRNMVIEMVLATDMSAHFNQVQVMK------------EGVLLPESLR-KINILSYVLHSADISHPCKPWEMHHQWTNMVVEEFFRQGDNEKEF-GLTCSPLCDRDSTLIPESQIGFINFIVEPCFLVLGDI 1289
            K  LN   KD   FSE + +    V  W+ +TFT +Q +V            R R RS++N VR      +  R  S  GS+          + +  + +++N W FD F      N H +  + Y +L +  L+  F I       ++  +E  Y L   P+HN IHAADV  T  +++S     N  +DLE+ S +I++ +HD +H G +N++ V  NS +AL+YND SVLENHHL+ AF+L++ +  +I ++L+  E +  R M+IEMVLATD + H + +  +K             GVL  E+   ++ +L  ++H AD+S+P KP  ++ +W + ++EEFFRQGD E++  G+  SP+ DR +  I +SQ+ FI+F+ +P +   G++
Sbjct:  118 KRLLNRELKD---FSEAN-QSGNQVSAWVYNTFTDKQLEVETAQSKTKRDCIRARSRSMVNGVR------KLTRLHSFSGSVPRFGVEVQNESELATILENVNKWDFDAFALGEATNGHPMLAVSYTILQARDLLKIFKIKPTTFINYMTLVENHY-LKDVPFHNCIHAADVTQTAHVLLSAQAFDNVFTDLEILSAIIASAVHDVDHPGVNNHFLVATNSEMALMYNDESVLENHHLAVAFQLLQHEDCDIFENLSKQERQTARRMIIEMVLATDNAKHMSLLASLKTMVETKKVAGTGSGVLCLENYTDRMQVLKSLVHCADLSNPTKPLPIYRKWVDRLMEEFFRQGDKERDIDGMEISPMMDRHNASIEKSQVVFIDFVAQPLWETWGEL 500
[Close]
BLAST of Phosphodiesterase vs. Ensembl Nematostella
Match: EDO32179 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7SVS5])

HSP 1 Score: 168.703 bits (426), Expect = 1.272e-46
Identity = 86/251 (34.26%), Postives = 149/251 (59.36%), Query Frame = 3 
Query:  549 LISRFSIDINVLEAFLDKLEEGYSLHQNPYHNLIHAADVAHTCFLIVSKSRLFNWLSDLELFSILISALIHDFEHTGTSNNYHVNLNSNLALIYNDRSVLENHHLSAAFRLMKDDRYNIVQSLNANEYRELRNMVIEMVLATDMSAHFNQV----QVMKEGVLLPESLRKINILSYVLHSADISHPCKPWEMHHQWTNMVVEEFFRQGDNEKEFGLTCSPLCDRDSTLIPESQIGFINFIVEPCFLVLGDI 1289
            L+  F I+ + L+ FL ++   Y  +  P+HN  HA  V    + ++  + +FN ++  +L  +L SAL HD +H G +N Y +N  + LAL YND S LENHH + AF +MK D+ NI+Q+++A  ++++R  +I+ +L+TDM+ H + +    +++K G    +   K  ++  ++  +D+S+  +P ++   W + +++EFF Q D EK  GL  +P  DRD    P +QIGFI F++ P F  LG++
Sbjct:  197 LLDEFKIERSKLQHFLFEVYRHY--NPTPFHNFRHAFCVTQMMYGLIWLTEIFNKITKQDLLIMLTSALCHDLDHPGYNNAYQINARTELALRYNDISPLENHHCAVAFDIMKQDKSNILQNVSAETFKKIREGMIKCILSTDMARHSDILNKFKELLKSGFKFDDEAHKSMLMQIMIKVSDVSNEARPMDVAEPWLDCLLQEFFIQSDVEKLEGLPVAPFMDRDKVTKPSAQIGFIKFVLVPLFEALGEL 445
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BLAST of Phosphodiesterase vs. Ensembl Nematostella
Match: EDO32142 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7SVX8])

HSP 1 Score: 167.162 bits (422), Expect = 1.622e-44
Identity = 97/306 (31.70%), Postives = 166/306 (54.25%), Query Frame = 3 
Query:  399 LPGSISAPPNAMIYLKQHINNWTFDIFHFNNLANNHSLKIMGYELLHSNQLISRFSIDINVLEAFLDKLEEGYSLHQNPYHNLIHAADVAHTCFLIVSKSRLFNWLSDLELFSILISALIHDFEHTGTSNNYHVNLNSNLALIYNDRSVLENHHLSAAFRL-MKDDRYNIVQSLNANEYRELRNMVIEMVLATDMSAHFNQVQVM------KEGVLLPESLRKIN-----------ILSYVLHSADISHPCKPWEMHHQWTNMVVEEFFRQGDNEKEFGL-TCSPLCDRDSTLIPESQIGFINFIV 1259
            +P  +S   NAM+       +W FDI      +N+  L  +G ++L+  ++  + +I  + ++ +L  +E  Y   +N YHN  HAADV H   + ++K R+   L  L+  + LI+A++HD +H G +N++  N  S LA++YND +VLE+HH + AF+L  +DD+ NI  +L+  E+R +R  +I+MV+AT+M+ HF  +         +     P+S    +           I   ++  ADI++P +P  +  +W   + EE+F Q D EK  GL    P+ DR +  +P SQ+ FI++ V
Sbjct:  509 IPAEVS---NAMV----DEADWDFDILKLEKASNHRPLYFLGLKILNRFRVCEKLNISEDYVKNWLQLIEANYH-RKNAYHNSTHAADVLHATAVFLAKERVKAVLEPLDEVASLIAAIVHDVDHPGYTNSFLCNAGSELAILYNDIAVLESHHAALAFKLTARDDKSNIFSNLDVEEFRTVRQAIIDMVMATEMTRHFEHLSKFVNSINKRRSSSTPDSNTSTSTALNTPENRTLIKRMLIKCADIANPARPRYLCKEWAYRIAEEYFSQTDEEKRRGLPVVMPVFDRATCNVPRSQVWFIDYFV 806
[Close]
BLAST of Phosphodiesterase vs. Ensembl Nematostella
Match: EDO43748 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7RXZ4])

HSP 1 Score: 152.525 bits (384), Expect = 1.141e-41
Identity = 98/331 (29.61%), Postives = 150/331 (45.32%), Query Frame = 3 
Query:  441 LKQHINNWTFDIFHFNNLANNHSLKIMGYELLHSNQLISRFSIDINVLEAFLDKLEEGYSLHQNPYHNLIHAADVAHTCFLIVSK------------------------------------------------SRLFNWLSDLELFSILISALIHDFEHTGTSNNYHVNLNSNLALIYNDRSVLENHHLSAAFR-LMKDDRYNIVQSLNANEYRELRNMVIEMVLATDMSAHFN-----QVQVMKEGVLLPESLRKINILSYVLHSADISHPCKPWEMHHQWTNMVVEEFFRQGDNEKEFGLTCSPLCDRDSTLIPESQIGFINFIVEPCF 1271
            L   + +W F IF  +   + + L  + Y +  +      F I       +   LE GY  H  PYHN IHA+DV    + + +                                                   L + +  LEL S+  +A +HD++H G +N + V   S+ AL+YNDRSVLENHH +AAF  LM D +YN +  L+  E++  R + IE +LATD+  HF+       +  + GV       ++  L + +  +DIS P K  ++H  WT  +VEEF+ QGD+E+  G+  SP  DR    + + Q  FIN +V P +
Sbjct:   19 LMDKVTDWNFPIF--DACEHGNILVQVSYRIFQNAGFFEIFKIPERKFLNYFFALESGY--HSIPYHNSIHASDVLQGVYFLTTAKIPGFCPPGTPQKLGDNESDSDSDSGITSGVLGEGEEDKKDDDGGGDYGALVDVIPLLELLSLYTAAAMHDYDHPGRTNAFLVATLSHQALLYNDRSVLENHHAAAAFTLLMSDPKYNFLCELSPAEFKRFRFLAIEAILATDLKRHFDILSDFNAKTAEGGVNWDSEADRLLTLQFCIKMSDISGPSKRRDIHTLWTERIVEEFYEQGDDERARGMAVSPYMDRQQPHVAQLQDSFINHLVAPLY 345
[Close]
BLAST of Phosphodiesterase vs. Ensembl Medaka
Match: pde1a (calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A [Source:NCBI gene;Acc:101168903])

HSP 1 Score: 386.726 bits (992), Expect = 6.896e-129
Identity = 183/426 (42.96%), Postives = 287/426 (67.37%), Query Frame = 3 
Query:  126 LENGEINRIVLINNLQDTSQFLDKAFLNSLSK---DEDIFSETDSE-LPENVQEWISSTFTKRQKVS---PPPRQRLRSLINAVRVGMYFDRAFRKVSLPGSISAPPNAMIYLKQHINNWTFDIFHFNNLANNHSLKIMGYELLHSNQLISRFSIDINVLEAFLDKLEEGYSLHQNPYHNLIHAADVAHTCFLIVSKSRLFNWLSDLELFSILISALIHDFEHTGTSNNYHVNLNSNLALIYNDRSVLENHHLSAAFRLMKDDRYNIVQSLNANEYRELRNMVIEMVLATDMSAHFNQVQVMKEGVLLPESLRKINILSYVLHSADISHPCKPWEMHHQWTNMVVEEFFRQGDNEKEFGLTCSPLCDRDSTLIPESQIGFINFIVEPCFLVLGD-IQKAISILCPDETLLSDDPSENSTVNGEKQI 1379
            ++ G ++   L  NL+  +  LD  + +   +    ED  S+  +E +P  V++W++ TF++R  +S   P  + R RS+++AV+ G++ +R +R+ S    ++ PP A+  LK+ ++ W+FD+F F++    H+LK + Y+LL    LI+RF I +  L  F++ LE GYS H+NPYHNLIHAADV  T   ++  + L +WLS+LE+ +++ +A IHDFEHTGT+NN+H++  S +A++YNDRSVLENHH+SAA++LM ++  NI+ +LN +++RELR++VIEMV++TDMS HF Q++ M+  +   +S+ K+ +LS +LH+ADISHP K W +H+ WT+ ++EEFFRQGD E E GL  SPLCDR +T+I +SQIGFI+FIVEP F VL D   K I  L  ++    +  +   ++ G   +
Sbjct:    1 MDRGVVDLQELRRNLELAAAMLDAVYTDETRRLLDTEDELSDLQAESVPSEVRDWLACTFSRRTGLSKRRPEEKPRFRSIVHAVQAGIFVERMYRRTSNMAGLTYPPTALNALKE-VDQWSFDVFTFHDATGEHALKFIVYDLLTRYDLINRFRIPVQALVQFVEALESGYSKHRNPYHNLIHAADVTQTAHFLMLHTGLMHWLSELEILAMVFAAAIHDFEHTGTTNNFHIHTRSEVAILYNDRSVLENHHVSAAYKLMAEEDMNILVNLNKDDWRELRSLVIEMVMSTDMSCHFQQIKTMRNSLTQTDSIDKVKVLSLMLHAADISHPAKAWPLHYHWTHSLMEEFFRQGDKEVELGLPFSPLCDRKATMIAQSQIGFIDFIVEPTFSVLIDTTDKVIGPLIEEDRKARETGNRRPSLTGSGSV 425
[Close]
BLAST of Phosphodiesterase vs. Ensembl Medaka
Match: ENSORLT00000022279.2 (pep primary_assembly:ASM223467v1:20:1384867:1412384:1 gene:ENSORLG00000017798.2 transcript:ENSORLT00000022279.2 gene_biotype:protein_coding transcript_biotype:protein_coding)

HSP 1 Score: 375.941 bits (964), Expect = 1.738e-126
Identity = 189/422 (44.79%), Postives = 286/422 (67.77%), Query Frame = 3 
Query:  126 LENGEINRIVLINNLQDTSQFLD-------KAFLNSLSKDEDIFSETDSELPENVQEWISSTFTKRQKVSPPPR---QRLRSLINAVRVGMYFDRAFRKVSLPGSISAPPNAMIYLKQHINNWTFDIFHFNNLANNHSLKIMGYELLHSNQLISRFSIDINVLEAFLDKLEEGYSLHQNPYHNLIHAADVAHTCFLIVSKSRLFNWLSDLELFSILISALIHDFEHTGTSNNYHVNLNSNLALIYNDRSVLENHHLSAAFRLM-KDDRYNIVQSLNANEYRELRNMVIEMVLATDMSAHFNQVQVMKEGVLLPESLRKINILSYVLHSADISHPCKPWEMHHQWTNMVVEEFFRQGDNEKEFGLTCSPLCDRDSTLIPESQIGFINFIVEPCFLVLGDIQKAISILCPDETLLSDDPSENST 1358
            LE G++    L  NL+  +  L+       +  ++   + +DI  +TDS +P  V++W++ TFT+++ +    R   QR RS+++AV+ G++ +R FR+ S   S+S   N +  LK H++ W+FD+F  N ++ NH+LK + +ELL    LI+ F I ++ L +F+D LE GYS H+NPYHNL+HAADV  T   ++ K+ + +WLS+LE+F+++ +A IHD+EHTGT+NN+H+   S+ AL+YNDR+V ENHH+SAA+RL+ +DD  NI  +L+ +E+R+LR++V++MVLATDMS HF Q++ MK  ++  E   K   LS +LH+ADISHP K W +HH+WT  ++EEFFRQGD E E GL  SPLCDR ST++ +SQIGFI+FIVEP F V+ ++ + I+     ET     PS  +T
Sbjct:    5 LERGQVPVADLKRNLEHAASLLEYMCSEETRQLVDPEDELDDI--KTDS-VPVEVRDWLTVTFTQQKGLVLTRREDKQRFRSIVHAVQAGIFVERMFRRTSNITSLSYSQNVITALK-HVDMWSFDVFALNEVSGNHALKFVFHELLTRYNLINVFKIPVSALISFVDSLEVGYSSHKNPYHNLVHAADVTQTLHYLLIKTGILHWLSELEIFAVIFAAAIHDYEHTGTTNNFHIQTRSDTALLYNDRAVQENHHISAAYRLLQRDDEKNIFLNLSKDEWRDLRSLVVDMVLATDMSCHFQQIKGMKNLMMQREHPDKPKALSLLLHTADISHPAKQWGLHHRWTTFLLEEFFRQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFTVVTEMIETITTALAQET----PPSGQTT 418
[Close]
BLAST of Phosphodiesterase vs. Ensembl Medaka
Match: ENSORLT00000006203.2 (phosphodiesterase 1B [Source:NCBI gene;Acc:101159577])

HSP 1 Score: 360.918 bits (925), Expect = 4.673e-118
Identity = 188/439 (42.82%), Postives = 280/439 (63.78%), Query Frame = 3 
Query:   54 MENKQISVQLARTLSENLKLCLSQLENGEINRIVLINNLQDTSQFLDKAFLNS----LSKDEDIFSETDSELPENVQEWISSTFTKRQKVSPPPRQ-----RLRSLINAVRVGMYFDRAFRKVSLPGSISAPPNAMIYLKQHINNWTFDIFHFNNLANNHSLKIMGYELLHSNQLISRFSIDINVLEAFLDKLEEGYSLHQNPYHNLIHAADVAHTCFLIVSKSRLFNWLSDLELFSILISALIHDFEHTGTSNNYHVNLNSNLALIYNDRSVLENHHLSAAFRLMKDDRYNIVQSLNANEYRELRNMVIEMVLATDMSAHFNQVQVMKEGVLLPESLRKINILSYVLHSADISHPCKPWEMHHQWTNMVVEEFFRQGDNEKEFGLTCSPLCDRDSTLIPESQIGFINFIVEPCFLVLGDIQKAISILCPDETLLSDDP 1343
            +  K++ + ++R     L+  L QLE  E+    +  NL  T+  L+  +L+     L  ++D+       +P  V +W++STFT  Q++  PPR+     + RS+++AV+ G++ +R F++ +   ++   P A++   + ++ W FD+F  N+ +++H+L+ + +EL+   +L +RF I I+ L  FL  LE GY  H NPYHN IHAADV  T   ++ +S L +WL++LE+   L +A IHDFEHTGT+NN+H++  S+LALIYNDRSV E+HHLSAAFRL++D++ NI   L   E+ ELR++VI+MVLATDM+ H  QV+ MK  +   E + K   LS +LH+ADISHP KPW +H +WT  ++EEFFRQGD E    L  SPLCDR +TLI ESQIGFI+FIV P F +L D+ + I I   +E     DP
Sbjct:    7 IRKKRLQIPISR-----LRNILKQLEEKEVEVEEIKKNLDVTALLLEGIYLDGTRQYLDSEDDLQQLQSDGVPSEVTDWLASTFT--QRIRQPPRRVDEKPKFRSIVHAVQAGIFVERMFKR-AYTAAMPDQPAAVVNCLRDVDRWGFDVFALNSTSSDHALQALFFELITRYELNTRFKIPISCLTKFLSTLERGYCKHNNPYHNHIHAADVTQTLHCLLLRSGLVHWLTELEVLGSLFAAAIHDFEHTGTTNNFHIHTKSDLALIYNDRSVQESHHLSAAFRLLQDEQVNIFVHLTREEWMELRSLVIDMVLATDMTFHLVQVKAMKSCLQQQERIDKPKALSLLLHTADISHPSKPWALHSRWTKALMEEFFRQGDREAALDLPFSPLCDRKTTLIAESQIGFIDFIVYPTFSLLTDMAEKIVIPLVEENPGPPDP 437
[Close]
BLAST of Phosphodiesterase vs. Ensembl Medaka
Match: pde4ca (cAMP-specific 3',5'-cyclic phosphodiesterase 4C [Source:NCBI gene;Acc:101161266])

HSP 1 Score: 240.736 bits (613), Expect = 2.881e-71
Identity = 148/426 (34.74%), Postives = 231/426 (54.23%), Query Frame = 3 
Query:   78 QLARTLSENLKLCLSQLENGEINRIVLINNLQDTSQFLDKAFLNSLSKDEDIFSETDSELPENVQEWISSTFTKRQK----VSPP-----PRQRLRSLINAVRVGMYFDRAFRKVSLPG-SISAPPNAMIYLK-QHINNWTFDIFHFNNLANNHSLKIMGYELLHSNQLISRFSIDINVLEAFLDKLEEGYSLHQNPYHNLIHAADVAHTCFLIVSKSRLFNWLSDLELFSILISALIHDFEHTGTSNNYHVNLNSNLALIYNDRSVLENHHLSAAFRLMKDDRYNIVQSLNANEYRELRNMVIEMVLATDMSAHFNQVQVMKE----------GVLLPESLR-KINILSYVLHSADISHPCKPWEMHHQWTNMVVEEFFRQGDNEKEFGLTCSPLCDRDSTLIPESQIGFINFIVEPCFLVLGDI 1289
            QLA    + L  CL QLE         +      S+     F   L+++    SET S     V E+ISSTF ++      +SPP      R+R  S I+ VR   Y   +    S+P   ++A    ++  + + IN W  DIF     +    L +  Y +     L+  F I +++   F+  LE+ Y   +  YHN IHAADV  +  +++S   L    +DLE+ + L ++ IHD +H G SN + +N NS LAL+YND SVLENHHL+  F+L+++D+ +I Q L+  + + LR MVI+MVLATDMS H N +  +K           GVLL ++   +I +L  ++H AD+S+P KP E++ +WT+ ++ EFF QGD E++ G+  SP+CD+ +  I ++Q+GFI++I  P +    D+
Sbjct:  144 QLAIETLDELDWCLEQLET--------LKTRHSVSEMASNKFKRMLNRELTQLSET-SRSGNQVSEFISSTFLEKSHDMDIMSPPSKEKDKRKRPMSQISGVRKPTY---SLAPSSIPRFGVNASQEGLLAKQLEDINRWGIDIFKVAEYSGTRPLTVTMYSIFQERDLLKTFKIPVDIFINFVMTLEDHYH-SEVAYHNNIHAADVVQSMHVLLSTPALEAVFTDLEILAALFASAIHDVDHPGVSNQFLINTNSELALMYNDMSVLENHHLAVGFKLLQEDQCDIFQDLSKKQRQSLRKMVIDMVLATDMSKHMNLLADLKTMVETKKVTSLGVLLLDNYSDRIQVLQNMVHCADLSNPTKPLELYRKWTDRIMVEFFTQGDRERDKGMEISPMCDKHNASIEKNQVGFIDYIAHPLWETWADL 556
[Close]
BLAST of Phosphodiesterase vs. Ensembl Medaka
Match: pde4ca (cAMP-specific 3',5'-cyclic phosphodiesterase 4C [Source:NCBI gene;Acc:101161266])

HSP 1 Score: 240.736 bits (613), Expect = 3.888e-71
Identity = 148/426 (34.74%), Postives = 231/426 (54.23%), Query Frame = 3 
Query:   78 QLARTLSENLKLCLSQLENGEINRIVLINNLQDTSQFLDKAFLNSLSKDEDIFSETDSELPENVQEWISSTFTKRQK----VSPP-----PRQRLRSLINAVRVGMYFDRAFRKVSLPG-SISAPPNAMIYLK-QHINNWTFDIFHFNNLANNHSLKIMGYELLHSNQLISRFSIDINVLEAFLDKLEEGYSLHQNPYHNLIHAADVAHTCFLIVSKSRLFNWLSDLELFSILISALIHDFEHTGTSNNYHVNLNSNLALIYNDRSVLENHHLSAAFRLMKDDRYNIVQSLNANEYRELRNMVIEMVLATDMSAHFNQVQVMKE----------GVLLPESLR-KINILSYVLHSADISHPCKPWEMHHQWTNMVVEEFFRQGDNEKEFGLTCSPLCDRDSTLIPESQIGFINFIVEPCFLVLGDI 1289
            QLA    + L  CL QLE         +      S+     F   L+++    SET S     V E+ISSTF ++      +SPP      R+R  S I+ VR   Y   +    S+P   ++A    ++  + + IN W  DIF     +    L +  Y +     L+  F I +++   F+  LE+ Y   +  YHN IHAADV  +  +++S   L    +DLE+ + L ++ IHD +H G SN + +N NS LAL+YND SVLENHHL+  F+L+++D+ +I Q L+  + + LR MVI+MVLATDMS H N +  +K           GVLL ++   +I +L  ++H AD+S+P KP E++ +WT+ ++ EFF QGD E++ G+  SP+CD+ +  I ++Q+GFI++I  P +    D+
Sbjct:  163 QLAIETLDELDWCLEQLET--------LKTRHSVSEMASNKFKRMLNRELTQLSET-SRSGNQVSEFISSTFLEKSHDMDIMSPPSKEKDKRKRPMSQISGVRKPTY---SLAPSSIPRFGVNASQEGLLAKQLEDINRWGIDIFKVAEYSGTRPLTVTMYSIFQERDLLKTFKIPVDIFINFVMTLEDHYH-SEVAYHNNIHAADVVQSMHVLLSTPALEAVFTDLEILAALFASAIHDVDHPGVSNQFLINTNSELALMYNDMSVLENHHLAVGFKLLQEDQCDIFQDLSKKQRQSLRKMVIDMVLATDMSKHMNLLADLKTMVETKKVTSLGVLLLDNYSDRIQVLQNMVHCADLSNPTKPLELYRKWTDRIMVEFFTQGDRERDKGMEISPMCDKHNASIEKNQVGFIDYIAHPLWETWADL 575
[Close]
BLAST of Phosphodiesterase vs. Planmine SMEST
Match: SMESG000044267.1 (SMESG000044267.1)

HSP 1 Score: 978.008 bits (2527), Expect = 0.000e+0
Identity = 473/477 (99.16%), Postives = 475/477 (99.58%), Query Frame = 3 
Query:   24 MLINVLGKDLMENKQISVQLARTLSENLKLCLSQLENGEINRIVLINNLQDTSQFLDKAFLNSLSKDEDIFSETDSELPENVQEWISSTFTKRQKVSPPPRQRLRSLINAVRVGMYFDRAFRKVSLPGSISAPPNAMIYLKQHINNWTFDIFHFNNLANNHSLKIMGYELLHSNQLISRFSIDINVLEAFLDKLEEGYSLHQNPYHNLIHAADVAHTCFLIVSKSRLFNWLSDLELFSILISALIHDFEHTGTSNNYHVNLNSNLALIYNDRSVLENHHLSAAFRLMKDDRYNIVQSLNANEYRELRNMVIEMVLATDMSAHFNQVQVMKEGVLLPESLRKINILSYVLHSADISHPCKPWEMHHQWTNMVVEEFFRQGDNEKEFGLTCSPLCDRDSTLIPESQIGFINFIVEPCFLVLGDIQKAISILCPDETLLSDDPSENSTVNGEKQIQTPWMDNLGNNKVKWAQLIKTKKEI 1454
            MLINVLGKDLMENKQISVQLARTLSENLKLCLSQLENGEINRIVLINNLQDTSQFLDKAFLNSLSKDEDIFSETDSELPENVQEWISSTFTKRQKVSPPPRQRLRSLINAVRVGMYFDRAFRKVSLPGSISAPPNAMIYLKQHINNWTFDIFHFNNLANNHSLKIMGYELLHSNQLISRFSIDINVLEAFLDKLEEGYSLHQNPYHNLIHAADVAHTCFLIVSKSRLFNWLSDLELFSILISALIHDFEHTGTSNNYHVNLNSNLALIYNDRSVLENHHLSAAFRLMKDDRYNIVQSLNANEYRELRNMVIEMVLATDMSAHFNQVQVMKEGVLLPESLRKINILSYVLHSADISHPCKPWEMHHQWTNMVVEEFFRQGDNEKEFGLTCSPLCDRDSTLIPESQIGFINFIVEPCFLVLGDIQKAISILCPDETLLSDDPSENSTVNGEKQIQTPWMDNLGNNKVKWAQLIK K+ +
Sbjct:    1 MLINVLGKDLMENKQISVQLARTLSENLKLCLSQLENGEINRIVLINNLQDTSQFLDKAFLNSLSKDEDIFSETDSELPENVQEWISSTFTKRQKVSPPPRQRLRSLINAVRVGMYFDRAFRKVSLPGSISAPPNAMIYLKQHINNWTFDIFHFNNLANNHSLKIMGYELLHSNQLISRFSIDINVLEAFLDKLEEGYSLHQNPYHNLIHAADVAHTCFLIVSKSRLFNWLSDLELFSILISALIHDFEHTGTSNNYHVNLNSNLALIYNDRSVLENHHLSAAFRLMKDDRYNIVQSLNANEYRELRNMVIEMVLATDMSAHFNQVQVMKEGVLLPESLRKINILSYVLHSADISHPCKPWEMHHQWTNMVVEEFFRQGDNEKEFGLTCSPLCDRDSTLIPESQIGFINFIVEPCFLVLGDIQKAISILCPDETLLSDDPSENSTVNGEKQIQTPWMDNLGNNKVKWAQLIKQKRRL 477
[Close]
BLAST of Phosphodiesterase vs. Planmine SMEST
Match: SMESG000044267.1 (SMESG000044267.1)

HSP 1 Score: 835.484 bits (2157), Expect = 0.000e+0
Identity = 406/406 (100.00%), Postives = 406/406 (100.00%), Query Frame = 3 
Query:   24 MLINVLGKDLMENKQISVQLARTLSENLKLCLSQLENGEINRIVLINNLQDTSQFLDKAFLNSLSKDEDIFSETDSELPENVQEWISSTFTKRQKVSPPPRQRLRSLINAVRVGMYFDRAFRKVSLPGSISAPPNAMIYLKQHINNWTFDIFHFNNLANNHSLKIMGYELLHSNQLISRFSIDINVLEAFLDKLEEGYSLHQNPYHNLIHAADVAHTCFLIVSKSRLFNWLSDLELFSILISALIHDFEHTGTSNNYHVNLNSNLALIYNDRSVLENHHLSAAFRLMKDDRYNIVQSLNANEYRELRNMVIEMVLATDMSAHFNQVQVMKEGVLLPESLRKINILSYVLHSADISHPCKPWEMHHQWTNMVVEEFFRQGDNEKEFGLTCSPLCDRDSTLIPESQIG 1241
            MLINVLGKDLMENKQISVQLARTLSENLKLCLSQLENGEINRIVLINNLQDTSQFLDKAFLNSLSKDEDIFSETDSELPENVQEWISSTFTKRQKVSPPPRQRLRSLINAVRVGMYFDRAFRKVSLPGSISAPPNAMIYLKQHINNWTFDIFHFNNLANNHSLKIMGYELLHSNQLISRFSIDINVLEAFLDKLEEGYSLHQNPYHNLIHAADVAHTCFLIVSKSRLFNWLSDLELFSILISALIHDFEHTGTSNNYHVNLNSNLALIYNDRSVLENHHLSAAFRLMKDDRYNIVQSLNANEYRELRNMVIEMVLATDMSAHFNQVQVMKEGVLLPESLRKINILSYVLHSADISHPCKPWEMHHQWTNMVVEEFFRQGDNEKEFGLTCSPLCDRDSTLIPESQIG
Sbjct:    1 MLINVLGKDLMENKQISVQLARTLSENLKLCLSQLENGEINRIVLINNLQDTSQFLDKAFLNSLSKDEDIFSETDSELPENVQEWISSTFTKRQKVSPPPRQRLRSLINAVRVGMYFDRAFRKVSLPGSISAPPNAMIYLKQHINNWTFDIFHFNNLANNHSLKIMGYELLHSNQLISRFSIDINVLEAFLDKLEEGYSLHQNPYHNLIHAADVAHTCFLIVSKSRLFNWLSDLELFSILISALIHDFEHTGTSNNYHVNLNSNLALIYNDRSVLENHHLSAAFRLMKDDRYNIVQSLNANEYRELRNMVIEMVLATDMSAHFNQVQVMKEGVLLPESLRKINILSYVLHSADISHPCKPWEMHHQWTNMVVEEFFRQGDNEKEFGLTCSPLCDRDSTLIPESQIG 406
[Close]
BLAST of Phosphodiesterase vs. Planmine SMEST
Match: SMESG000070067.1 (SMESG000070067.1)

HSP 1 Score: 544.658 bits (1402), Expect = 0.000e+0
Identity = 256/472 (54.24%), Postives = 349/472 (73.94%), Query Frame = 3 
Query:   75 VQLARTLSENLKLCLSQLENGEINRIVLINNLQDTSQFLDKAFLN--SLSKDEDIFSETDSELPENVQEWISSTFTKRQKVSPPPRQRLRSLINAVRVGMYFDRAFRKVSLPGSISAPPNAMIYLKQHINNWTFDIFHFNNLANNHSLKIMGYELLHSNQLISRFSIDINVLEAFLDKLEEGYSLHQNPYHNLIHAADVAHTCFLIVSKSRLFNWLSDLELFSILISALIHDFEHTGTSNNYHVNLNSNLALIYNDRSVLENHHLSAAFRLMKDDRYNIVQSLNANEYRELRNMVIEMVLATDMSAHFNQVQVMKEGVLLPESLRKINILSYVLHSADISHPCKPWEMHHQWTNMVVEEFFRQGDNEKEFGLTCSPLCDRDSTLIPESQIGFINFIVEPCFLVLGDIQKAISILCP---------DETLLS--DDPSENSTVNGEKQIQTPWMDNLGNNKVKWAQLIKTKKE 1451
            ++ A T+ E+LK     +   +I+  +LI NL + + FL+K F N  S+  DE+IF + +S+LPENVQ+WIS+TFT R       R RL+SL+  V+ G+YFDR +R+VS+      PP+ M Y+K  +N+W FD+FHFN L  NHSLK +GYEL+H   +ISRF ID+  LE+FL K+EEGYSLH NPYHNLIHAADVA TCF+++SKS+L +W++D+E+ +ILI+A+IHD+EHTGT+NNYHV  +S+LALIYNDRSVLEN+H+S+AF L++  +YNI+ SLN  EY++ R +VIEMVLATDMS HFNQ+Q MK+ ++LPE+L+KINILS+VLHSADISHP K W++H QWTN+VVEEFF+QGD E+  GL CSPLCDR +TLIP+SQIGFINFIVEPCF  L D+  A+ IL P         D+++L    +P+ +  +  ++    PW  ++ +NK+ W +L+    E
Sbjct:    9 LKTANTIVESLKTSTELILKKKISNKILIENLNEAAHFLEKTFYNRTSVCPDEEIFPDAESDLPENVQDWISNTFTSRTTQYKQHRTRLKSLVKLVQAGIYFDRIYRRVSISSDNFVPPSVMSYMKDKLNSWEFDMFHFNTLCRNHSLKAIGYELMHHTNMISRFLIDLTRLESFLSKMEEGYSLHNNPYHNLIHAADVAQTCFILISKSKLISWMTDIEVLAILIAAIIHDYEHTGTTNNYHVVTSSDLALIYNDRSVLENYHVSSAFTLLQQTQYNILNSLNKEEYKQFRTIVIEMVLATDMSIHFNQLQTMKDAIMLPENLQKINILSFVLHSADISHPTKSWDLHQQWTNLVVEEFFQQGDRERTEGLPCSPLCDRHTTLIPQSQIGFINFIVEPCFQTLSDMFDAVVILFPIDESKKEIVDDSILERPSNPTPSRVIISDR----PWFVHIFDNKLNWTELVNKANE 476
[Close]
BLAST of Phosphodiesterase vs. Planmine SMEST
Match: SMESG000004031.1 (SMESG000004031.1)

HSP 1 Score: 422.935 bits (1086), Expect = 3.374e-143
Identity = 199/454 (43.83%), Postives = 307/454 (67.62%), Query Frame = 3 
Query:  111 LCLSQL-ENGEINRIVLINNLQDTSQFLDKAFLNSLSK----DEDIFSETDSELPENVQEWISSTFTKR--QKVSPPPRQRLRSLINAVRVGMYFDRAFRKVSLPGSISAPPNAMIYLKQHINNWTFDIFHFNNLANNHSLKIMGYELLHSNQLISRFSIDINVLEAFLDKLEEGYSLHQNPYHNLIHAADVAHTCFLIVSKSRLFNWLSDLELFSILISALIHDFEHTGTSNNYHVNLNSNLALIYNDRSVLENHHLSAAFRLMKDDRYNIVQSLNANEYRELRNMVIEMVLATDMSAHFNQVQVMKEGVLLPESLRKINILSYVLHSADISHPCKPWEMHHQWTNMVVEEFFRQGDNEKEFGLTCSPLCDRDSTLIPESQIGFINFIVEPCFLVLGDIQKAISILCPDETLLSDDPSENSTVNGEKQIQTPWMDNLGNNKVKWAQLIKTKKE 1451
            LC+ +L +  +I++  L+ N+      L+ A++    +    D+D  ++ +  +P+ V+EW+S+TFT+R         + + RS+ NA+R G+  +R +R++S    +  PPN MI +K  +++W F++F  +  + NHSLK +GYEL H   ++++F ID  +LE FL KLE+GY+   NPYH+  HAADVA TC +I+S+S L  W++DLE+ ++L +ALIHD+EHTGT+N +HVN +S+LAL+YNDR VLENHH+S+ FRL++++ Y I + L   EY+ELR +VIE+VL TDMS HF Q++ MK  + +PE++ KI   S ++H ADISHP K W +H +WT ++VEEFFRQGD EKE GL+CSPLCDR++T++ +SQIGFI+FIVEP F++LGD+   +  +  +    + +P +N       ++Q PW+  +  NK  W ++   KKE
Sbjct:  102 LCIIKLIQKNKISKEDLLKNINYAILVLESAYIEEAKRICNEDDDFPTQANGSVPDEVREWLSNTFTRRTSSTAGKDEKPKFRSVANAIRAGILVERIYRRMSSSAGLPIPPNVMILMKAGLDSWNFNVFEVDEASENHSLKYLGYELFHKYNMMTKFKIDSVILENFLQKLEDGYAKFSNPYHSFTHAADVAQTCHIIISQSGLSRWMTDLEILAVLFAALIHDYEHTGTTNGFHVNSSSDLALLYNDRGVLENHHISSVFRLIREESYQIFKGLTKEEYKELRLLVIEIVLNTDMSLHFQQLKNMKTLLAVPENVEKIKAFSLLVHCADISHPTKQWHLHEKWTLLLVEEFFRQGDREKELGLSCSPLCDRNTTVVAQSQIGFIDFIVEPSFVLLGDMLDRMMQMAQN----NKEPIQND--EDFTKVQRPWIQCINENKEAW-KIRAPKKE 548
[Close]
BLAST of Phosphodiesterase vs. Planmine SMEST
Match: SMESG000009966.1 (SMESG000009966.1)

HSP 1 Score: 378.637 bits (971), Expect = 1.653e-126
Identity = 188/471 (39.92%), Postives = 305/471 (64.76%), Query Frame = 3 
Query:   87 RTLSENLKLCL------SQLENGEINRIVLINNLQDTSQFLDKAFLN----SLSKDEDIFSETDSELPENVQEWISSTF-TKRQKVSPPPRQRLRSLINAVRVGMYFDRAFRKVSLPGSISAPPNAMIYLKQHINNWTFDIFHFNNLANNHSLKIMGYELLHSNQLISRFSIDINVLEAFLDKLEEGYSLHQNPYHNLIHAADVAHTCFLIVSKSRLFNWLSDLELFSILISALIHDFEHTGTSNNYHVNLNSNLALIYNDRSVLENHHLSAAFRLMKDDRYNIVQSLNANEYRELRNMVIEMVLATDMSAHFNQVQVMKEGVLLPESLRKINILSYVLHSADISHPCKPWEMHHQWTNMVVEEFFRQGDNEKEFGLTCSPLCDRDSTLIPESQIGFINFIVEPCFLVLGDIQKAISILCPDETL---LSDDPS--ENSTVNGEKQIQTPWMDNLGNNKVKWAQLIKTKKE 1451
            + LS+ ++ C+        + +  I +  LI +L  T + +D A  N    ++++D++I   TD+ +P  ++EW++STF T   +VS   + + R++ NA+R G+  ++ F+K +   ++  P +   +L+  IN W+FDIF  ++++  H+L+ +G +L      I ++ I++   + F   LE+GYS + NPYHNL+H ADVA T   ++   +L NWL+D+++F+ + +ALIHDFEHTGT+NN+HVN NS+L ++YND+ VLENHH+SA FRLM+    N++++++  +YRE R++VIEMVL TDMS HF Q++ MK  + L E++ K + LS +LH ADISHP K W++H++WT  ++EEFFRQGD E +  +  SPLCDR S +IPESQ+GF NFIVEP F +LG++ + I  +   + +   ++++ S  +N+ V G   I  PW   + NN+  W + I  +KE
Sbjct:   23 KALSQFIECCIRVRQVIKLIHSDGIRKEDLIKSLAYTVELMD-AIANEEQININEDDEINVNTDA-VPGEIREWLTSTFSTSASRVSRIEKPKFRAVANAIRAGIMVEKIFKKSNEIAALKIPNDISKFLRSDINEWSFDIFKLDDMSGGHALRFIGLDLFLRYNFIHKYKINLQYFDNFFQALEDGYSKYGNPYHNLVHGADVAQTVHFMIYTYQLNNWLTDIQIFAAIFAALIHDFEHTGTTNNFHVNTNSDLTILYNDKGVLENHHVSACFRLMQQPHMNLMKNVDKEDYREFRSIVIEMVLNTDMSTHFKQMKSMKSMLALEENIDKGSALSTILHCADISHPAKDWDLHYRWTTQLLEEFFRQGDQESQLEIPFSPLCDRKSIMIPESQVGFSNFIVEPSFNILGNMLEFIIGMMKKDGIKLEIAENISIAQNAPVKG--SIHFPWEAKIVNNRSTWQKQIDQRKE 489
The following BLAST results are available for this feature:
BLAST of Phosphodiesterase vs. Ensembl Human
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Human e!99)
Total hits: 5
Match NameE-valueIdentityDescription
PDE1C5.519e-13646.08phosphodiesterase 1C [Source:HGNC Symbol;Acc:HGNC:... [more]
PDE1C5.519e-13646.08phosphodiesterase 1C [Source:HGNC Symbol;Acc:HGNC:... [more]
PDE1C1.277e-13446.08phosphodiesterase 1C [Source:HGNC Symbol;Acc:HGNC:... [more]
PDE1C1.277e-13446.08phosphodiesterase 1C [Source:HGNC Symbol;Acc:HGNC:... [more]
PDE1C1.078e-13246.51phosphodiesterase 1C [Source:HGNC Symbol;Acc:HGNC:... [more]
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BLAST of Phosphodiesterase vs. Ensembl Celegans
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99)
Total hits: 5
Match NameE-valueIdentityDescription
pde-11.629e-12640.08Probable 3',5'-cyclic phosphodiesterase pde-1 [So... [more]
pde-19.700e-12640.21Probable 3',5'-cyclic phosphodiesterase pde-1 [So... [more]
pde-41.034e-6932.24Probable 3',5'-cyclic phosphodiesterase pde-4 [So... [more]
pde-43.519e-6932.24Probable 3',5'-cyclic phosphodiesterase pde-4 [So... [more]
pde-45.094e-6932.24Probable 3',5'-cyclic phosphodiesterase pde-4 [So... [more]
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BLAST of Phosphodiesterase vs. Ensembl Fly
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99)
Total hits: 5
Match NameE-valueIdentityDescription
Pde1c5.053e-12345.24gene:FBgn0264815 transcript:FBtr0334137[more]
Pde1c6.253e-12044.19gene:FBgn0264815 transcript:FBtr0334135[more]
Pde1c1.221e-11945.24gene:FBgn0264815 transcript:FBtr0334136[more]
Pde1c1.221e-11945.24gene:FBgn0264815 transcript:FBtr0334140[more]
Pde1c1.378e-11945.24gene:FBgn0264815 transcript:FBtr0344148[more]
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BLAST of Phosphodiesterase vs. Ensembl Zebrafish
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99)
Total hits: 5
Match NameE-valueIdentityDescription
pde1a9.534e-13544.36phosphodiesterase 1A, calmodulin-dependent [Source... [more]
pde1a8.662e-13445.07phosphodiesterase 1A, calmodulin-dependent [Source... [more]
CABZ01067973.12.807e-12944.79phosphodiesterase 1C, calmodulin-dependent b [Sour... [more]
pde4a2.901e-7035.38phosphodiesterase 4A, cAMP-specific [Source:ZFIN;A... [more]
pde4d4.388e-7033.64phosphodiesterase 4D, cAMP-specific [Source:ZFIN;A... [more]
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BLAST of Phosphodiesterase vs. Ensembl Xenopus
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99)
Total hits: 5
Match NameE-valueIdentityDescription
arhgef398.283e-13342.89Rho guanine nucleotide exchange factor 39 [Source:... [more]
PDE1C1.120e-13246.42phosphodiesterase 1C [Source:NCBI gene;Acc:1004953... [more]
arhgef391.596e-13242.89Rho guanine nucleotide exchange factor 39 [Source:... [more]
PDE1C1.642e-13246.42phosphodiesterase 1C [Source:NCBI gene;Acc:1004953... [more]
PDE1C5.758e-13245.78phosphodiesterase 1C [Source:NCBI gene;Acc:1004953... [more]
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BLAST of Phosphodiesterase vs. Ensembl Mouse
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99)
Total hits: 5
Match NameE-valueIdentityDescription
Pde1c1.783e-13544.60phosphodiesterase 1C [Source:MGI Symbol;Acc:MGI:10... [more]
Pde1c5.621e-13544.60phosphodiesterase 1C [Source:MGI Symbol;Acc:MGI:10... [more]
Pde1c5.621e-13544.60phosphodiesterase 1C [Source:MGI Symbol;Acc:MGI:10... [more]
Pde1c9.280e-13544.60phosphodiesterase 1C [Source:MGI Symbol;Acc:MGI:10... [more]
Pde1c9.280e-13544.60phosphodiesterase 1C [Source:MGI Symbol;Acc:MGI:10... [more]
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BLAST of Phosphodiesterase vs. UniProt/SwissProt
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt)
Total hits: 5
Match NameE-valueIdentityDescription
sp|Q14123|PDE1C_HUMAN6.132e-13446.08Calcium/calmodulin-dependent 3',5'-cyclic nucleoti... [more]
sp|Q64338|PDE1C_MOUSE3.055e-13344.60Calcium/calmodulin-dependent 3',5'-cyclic nucleoti... [more]
sp|Q63421|PDE1C_RAT1.397e-13146.27Calcium/calmodulin-dependent 3',5'-cyclic nucleoti... [more]
sp|P14100|PDE1A_BOVIN1.392e-12842.82Calcium/calmodulin-dependent 3',5'-cyclic nucleoti... [more]
sp|Q61481|PDE1A_MOUSE5.540e-12643.61Calcium/calmodulin-dependent 3',5'-cyclic nucleoti... [more]
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BLAST of Phosphodiesterase vs. TrEMBL
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL)
Total hits: 5
Match NameE-valueIdentityDescription
A0A267EIK01.581e-14646.22Phosphodiesterase OS=Macrostomum lignano OX=282301... [more]
A0A267EML72.567e-14646.22Phosphodiesterase OS=Macrostomum lignano OX=282301... [more]
A0A267DMF63.464e-14145.13Phosphodiesterase OS=Macrostomum lignano OX=282301... [more]
A0A267DMU51.328e-13945.13Phosphodiesterase OS=Macrostomum lignano OX=282301... [more]
A0A4S2MDP03.301e-13843.75Phosphodiesterase OS=Opisthorchis felineus OX=1478... [more]
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BLAST of Phosphodiesterase vs. Ensembl Cavefish
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99)
Total hits: 5
Match NameE-valueIdentityDescription
PDE1C3.850e-13643.52phosphodiesterase 1C [Source:NCBI gene;Acc:1030407... [more]
PDE1C1.120e-13344.52phosphodiesterase 1C [Source:NCBI gene;Acc:1030407... [more]
PDE1C1.818e-13345.37phosphodiesterase 1C [Source:NCBI gene;Acc:1030407... [more]
PDE1C2.102e-13341.41phosphodiesterase 1C [Source:NCBI gene;Acc:1030407... [more]
ENSAMXT00000048550.12.920e-12545.30pep primary_assembly:Astyanax_mexicanus-2.0:17:437... [more]
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BLAST of Phosphodiesterase vs. Ensembl Sea Lamprey
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99)
Total hits: 5
Match NameE-valueIdentityDescription
pde1a3.710e-13641.68phosphodiesterase 1A, calmodulin-dependent [Source... [more]
PDE1C4.133e-12743.03phosphodiesterase 1C [Source:HGNC Symbol;Acc:HGNC:... [more]
ENSPMAT00000003038.12.787e-5847.31pep scaffold:Pmarinus_7.0:GL476485:41:13228:1 gene... [more]
ENSPMAT00000007435.13.414e-5144.27pep scaffold:Pmarinus_7.0:GL486982:1709:8825:-1 ge... [more]
pde7a1.179e-4834.30phosphodiesterase 7A [Source:ZFIN;Acc:ZDB-GENE-031... [more]
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BLAST of Phosphodiesterase vs. Ensembl Yeast
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46)
Total hits: 1
Match NameE-valueIdentityDescription
PDE21.709e-1025.96High-affinity cyclic AMP phosphodiesterase; compon... [more]
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BLAST of Phosphodiesterase vs. Ensembl Nematostella
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46)
Total hits: 5
Match NameE-valueIdentityDescription
EDO373013.590e-11044.44Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7... [more]
EDO461331.090e-6433.50Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7... [more]
EDO321791.272e-4634.26Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7... [more]
EDO321421.622e-4431.70Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7... [more]
EDO437481.141e-4129.61Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7... [more]
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BLAST of Phosphodiesterase vs. Ensembl Medaka
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99)
Total hits: 5
Match NameE-valueIdentityDescription
pde1a6.896e-12942.96calcium/calmodulin-dependent 3',5'-cyclic nucleoti... [more]
ENSORLT00000022279.21.738e-12644.79pep primary_assembly:ASM223467v1:20:1384867:141238... [more]
ENSORLT00000006203.24.673e-11842.82phosphodiesterase 1B [Source:NCBI gene;Acc:1011595... [more]
pde4ca2.881e-7134.74cAMP-specific 3',5'-cyclic phosphodiesterase 4C [S... [more]
pde4ca3.888e-7134.74cAMP-specific 3',5'-cyclic phosphodiesterase 4C [S... [more]
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BLAST of Phosphodiesterase vs. Planmine SMEST
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST)
Total hits: 5
Match NameE-valueIdentityDescription
SMESG000044267.10.000e+099.16SMESG000044267.1[more]
SMESG000044267.10.000e+0100.00SMESG000044267.1[more]
SMESG000070067.10.000e+054.24SMESG000070067.1[more]
SMESG000004031.13.374e-14343.83SMESG000004031.1[more]
SMESG000009966.11.653e-12639.92SMESG000009966.1[more]
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Sequences
The following sequences are available for this feature:

transcript sequence

>SMED30011414 ID=SMED30011414|Name=Phosphodiesterase|organism=Schmidtea mediterranea sexual|type=transcript|length=1511bp
ATTGAAATGAAATATTAAATAAAATGCTCATAAATGTATTAGGAAAAGAT
TTAATGGAAAACAAACAAATTTCAGTGCAATTAGCTAGGACATTATCAGA
AAATCTGAAACTCTGCCTCAGTCAATTAGAAAACGGGGAAATAAACCGAA
TAGTTCTCATCAATAACCTTCAGGACACCTCTCAATTTCTTGACAAGGCA
TTTTTGAATTCACTTTCTAAAGACGAAGACATTTTCTCAGAAACTGATTC
TGAGCTTCCAGAAAATGTCCAAGAATGGATTTCGTCGACATTCACGAAAC
GACAAAAGGTTTCTCCACCTCCAAGACAAAGATTGCGAAGCCTAATAAAT
GCCGTTCGTGTGGGTATGTATTTTGATAGAGCATTCAGAAAGGTCTCATT
GCCGGGCTCGATTTCTGCCCCTCCCAATGCGATGATCTATTTAAAACAAC
ACATAAACAATTGGACTTTTGATATTTTCCATTTCAACAATCTCGCTAAC
AATCATTCATTGAAAATAATGGGCTATGAGTTGTTGCACTCGAATCAGTT
GATCAGTCGATTTTCAATCGATATAAATGTGCTAGAGGCATTCCTCGACA
AACTGGAAGAAGGCTATAGCCTGCACCAGAATCCTTATCATAACCTGATC
CACGCCGCCGATGTTGCTCACACCTGTTTTTTGATTGTATCGAAAAGTCG
CTTGTTTAACTGGTTGAGCGATTTGGAATTATTCAGTATTCTAATATCGG
CGTTGATTCACGATTTCGAGCACACTGGAACTTCCAATAATTACCACGTG
AATTTAAACTCCAATTTAGCGTTGATTTATAATGACAGATCTGTGTTGGA
AAACCATCACTTAAGTGCGGCATTCCGCCTCATGAAGGATGATCGCTATA
ATATTGTCCAATCGCTAAACGCGAACGAATACCGCGAGTTGAGGAATATG
GTTATTGAAATGGTTCTCGCTACTGACATGTCTGCTCATTTCAATCAAGT
ACAGGTAATGAAGGAGGGAGTTTTGTTGCCCGAAAGTCTTAGGAAAATTA
ATATTCTATCATATGTATTACATTCTGCTGATATAAGTCATCCATGCAAA
CCTTGGGAAATGCATCATCAATGGACAAATATGGTAGTGGAAGAGTTTTT
CAGACAAGGAGACAATGAGAAAGAATTTGGACTCACTTGTAGTCCATTAT
GTGATCGGGATTCAACATTAATACCAGAATCTCAAATCGGATTTATCAAT
TTCATAGTGGAGCCATGTTTCCTTGTTCTTGGTGACATTCAGAAGGCCAT
ATCAATTCTTTGCCCCGATGAAACACTACTTTCAGACGATCCTAGTGAGA
ATTCGACAGTAAATGGCGAAAAGCAAATACAAACTCCTTGGATGGATAAT
TTGGGAAATAATAAAGTGAAATGGGCGCAACTGATTAAAACAAAAAAGGA
GATTGATACAATTCACGAAGAATCAGAAAATGATGATTAAAAATAAAATT
TAAATAATTTA
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protein sequence of SMED30011414-orf-1

>SMED30011414-orf-1 ID=SMED30011414-orf-1|Name=SMED30011414-orf-1|organism=Schmidtea mediterranea sexual|type=polypeptide|length=489bp
MLINVLGKDLMENKQISVQLARTLSENLKLCLSQLENGEINRIVLINNLQ
DTSQFLDKAFLNSLSKDEDIFSETDSELPENVQEWISSTFTKRQKVSPPP
RQRLRSLINAVRVGMYFDRAFRKVSLPGSISAPPNAMIYLKQHINNWTFD
IFHFNNLANNHSLKIMGYELLHSNQLISRFSIDINVLEAFLDKLEEGYSL
HQNPYHNLIHAADVAHTCFLIVSKSRLFNWLSDLELFSILISALIHDFEH
TGTSNNYHVNLNSNLALIYNDRSVLENHHLSAAFRLMKDDRYNIVQSLNA
NEYRELRNMVIEMVLATDMSAHFNQVQVMKEGVLLPESLRKINILSYVLH
SADISHPCKPWEMHHQWTNMVVEEFFRQGDNEKEFGLTCSPLCDRDSTLI
PESQIGFINFIVEPCFLVLGDIQKAISILCPDETLLSDDPSENSTVNGEK
QIQTPWMDNLGNNKVKWAQLIKTKKEIDTIHEESENDD*
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Annotated Terms
The following terms have been associated with this transcript:
Vocabulary: Planarian Anatomy
TermDefinition
PLANA:0000418head
Vocabulary: INTERPRO
TermDefinition
IPR036971PDEase_catalytic_dom_sf
IPR023088PDEase
IPR003607HD/PDEase_dom
IPR002073PDEase_catalytic_dom
IPR013706PDEase_N
IPR023174PDEase_CS
Vocabulary: molecular function
TermDefinition
GO:0008081phosphoric diester hydrolase activity
GO:00041143',5'-cyclic-nucleotide phosphodiesterase activity
GO:0016787hydrolase activity
GO:0046872metal ion binding
Vocabulary: biological process
TermDefinition
GO:0007165signal transduction
InterPro
Analysis Name: Schmidtea mediteranean smed_20140614 Interproscan
Date Performed: 2020-05-01
IPR TermIPR DescriptionSourceSource TermSource DescriptionAlignment
IPR0230883'5'-cyclic nucleotide phosphodiesterasePRINTSPR00387PDIESTERASE1coord: 232..245
score: 37.86
coord: 349..362
score: 50.43
coord: 273..289
score: 52.82
coord: 246..261
score: 46.62
coord: 366..382
score: 53.65
coord: 201..214
score: 55.14
IPR003607HD/PDEase domainSMARTSM00471hd_13coord: 203..367
e-value: 3.0E-5
score: 33.4
IPR003607HD/PDEase domainCDDcd00077HDccoord: 205..376
e-value: 2.85269E-13
score: 65.0533
IPR0137063'5'-cyclic nucleotide phosphodiesterase N-terminalPFAMPF08499PDEase_I_Ncoord: 66..119
e-value: 4.6E-8
score: 32.8
IPR0369713'5'-cyclic nucleotide phosphodiesterase, catalytic domain superfamilyGENE3DG3DSA:1.10.1300.10coord: 130..476
e-value: 1.0E-125
score: 421.6
IPR0020733'5'-cyclic nucleotide phosphodiesterase, catalytic domainPFAMPF00233PDEase_Icoord: 205..426
e-value: 1.2E-79
score: 267.4
IPR0020733'5'-cyclic nucleotide phosphodiesterase, catalytic domainPROSITEPS51845PDEASE_I_2coord: 122..474
score: 113.908
NoneNo IPR availablePANTHERPTHR11347:SF199CALCIUM/CALMODULIN-DEPENDENT 3',5'-CYCLIC NUCLEOTIDE PHOSPHODIESTERASE 1coord: 18..475
NoneNo IPR availablePANTHERPTHR11347CYCLIC NUCLEOTIDE PHOSPHODIESTERASEcoord: 18..475
NoneNo IPR availableSUPERFAMILYSSF109604HD-domain/PDEase-likecoord: 135..481
IPR0231743'5'-cyclic nucleotide phosphodiesterase, conserved sitePROSITEPS00126PDEASE_I_1coord: 246..257