HORMA domain-containing protein

Overview
NameHORMA domain-containing protein
Smed IDSMED30011381
Length (bp)1619
Neoblast Clusters

Zeng et. al., 2018




▻ Overview

▻ Neoblast Population

▻ Sub-lethal Irradiated Surviving X1 and X2 Cell Population

 



 

Overview

 

Single cell RNA-seq of pluripotent neoblasts and its early progenies


We isolated X1 neoblasts cells enriched in high piwi-1 expression (Neoblast Population), and profiled ∼7,614 individual cells via scRNA-seq. Unsupervised analyses uncovered 12 distinct classes from 7,088 high-quality cells. We designated these classes Nb1 to Nb12 and ordered them based on high (Nb1) to low (Nb12) piwi-1 expression levels. We further defined groups of genes that best classified the cells parsed into 12 distinct cell clusters to generate a scaled expression heat map of discriminative gene sets for each cluster. Expression of each cluster’s gene signatures was validated using multiplex fluorescence in situ hybridization (FISH) co-stained with piwi-1 and largely confirmed the cell clusters revealed by scRNA-seq.

We also tested sub-lethal irradiation exposure. To profile rare pluripotent stem cells (PSCs) and avoid interference from immediate progenitor cells, we determined a time point after sub-lethal irradiation (7 DPI) with minimal piwi-1+ cells, followed by isolation and single-cell RNA-seq of 1,200 individual cells derived from X1 (Piwi-1 high) and X2 (Piwi-1 low) cell populations (Sub-lethal Irradiated Surviving X1 and X2 Cell Population)




Explore this single cell expression dataset with our NB Cluster Shiny App




 

Neoblast Population

 

t-SNE plot shows two-dimensional representation of global gene expression relationships among all neoblasts (n = 7,088 after filter). Cluster identity was assigned based on the top 10 marker genes of each cluster (Table S2), followed by inspection of RNA in situ hybridization patterns. Neoblast groups, Nb.


Expression of HORMA domain-containing protein (SMED30011381) t-SNE clustered cells

Violin plots show distribution of expression levels for HORMA domain-containing protein (SMED30011381) in cells (dots) of each of the 12 neoblast clusters.

 

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Sub-lethal Irradiated Surviving X1 and X2 Cell Population

 

t-SNE plot of surviving X1 and X2 cells (n = 1,039 after QC filter) after sub-lethal irradiation. Colors indicate unbiased cell classification via graph-based clustering. SL, sub-lethal irradiated cell groups.

Expression of HORMA domain-containing protein (SMED30011381) in the t-SNE clustered sub-lethally irradiated X1 and X2 cells.

Violin plots show distribution of expression levels for HORMA domain-containing protein (SMED30011381) in cells (dots) of each of the 10 clusters of sub-leathally irradiated X1 and X2 cells.

 

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Embryonic Expression

Davies et. al., 2017




Hover the mouse over a column in the graph to view average RPKM values per sample.
Sort Descending | Sort Ascending | Only Non-Zero Values | Tile/Chart | Reset

Embryonic Stages: Y: yolk. S2-S8: Stages 2-8. C4: asexual adult. SX: virgin, sexually mature adult.
For further information about sample preparation and analysis for the single animal RNA-Seq experiment, please refer to the Materials and Methods

 

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Anatomical Expression

PAGE et. al., 2020




SMED30011381

has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGE



PAGE Curations: 24

  
Expressed InReference TranscriptGene ModelsPublished TranscriptTranscriptomePublicationSpecimenLifecycleEvidence
intestinal phagocyteSMED30011381SMESG000066514.1 Contig82uc_Smed_v2PMID:23079596
Forsthoefel et al., 2012
FACS sorted cell population asexual adult cDNA to DNA expression microarray evidence
intestinal phagocyteSMED30011381SMESG000066514.1 Contig82newmark_estsPMID:23079596
Forsthoefel et al., 2012
FACS sorted cell population asexual adult cDNA to DNA expression microarray evidence
intestinal phagocyteSMED30011381SMESG000066514.1 Contig4866uc_Smed_v2PMID:23079596
Forsthoefel et al., 2012
FACS sorted cell population asexual adult cDNA to DNA expression microarray evidence
intestinal phagocyteSMED30011381SMESG000066514.1 Contig4866newmark_estsPMID:23079596
Forsthoefel et al., 2012
FACS sorted cell population asexual adult cDNA to DNA expression microarray evidence
intestinal phagocyteSMED30011381SMESG000035878.1 Contig82uc_Smed_v2PMID:23079596
Forsthoefel et al., 2012
FACS sorted cell population asexual adult cDNA to DNA expression microarray evidence
intestinal phagocyteSMED30011381SMESG000035878.1 Contig82newmark_estsPMID:23079596
Forsthoefel et al., 2012
FACS sorted cell population asexual adult cDNA to DNA expression microarray evidence
intestinal phagocyteSMED30011381SMESG000075530.1 Contig4866uc_Smed_v2PMID:23079596
Forsthoefel et al., 2012
FACS sorted cell population asexual adult cDNA to DNA expression microarray evidence
intestinal phagocyteSMED30011381SMESG000075530.1 Contig4866newmark_estsPMID:23079596
Forsthoefel et al., 2012
FACS sorted cell population asexual adult cDNA to DNA expression microarray evidence
X1 cellSMED30011381SMESG000066514.1 SmedASXL_015454SmedAsxl_ww_GCZZ01PMID:26114597
Zhu et al., 2015
FACS sorted cell population asexual adult RNA-sequencing evidence
X2 cellSMED30011381SMESG000066514.1 SmedASXL_015454SmedAsxl_ww_GCZZ01PMID:26114597
Zhu et al., 2015
FACS sorted cell population asexual adult RNA-sequencing evidence
pharynxSMED30011381SMESG000066514.1 dd_Smed_v4_2201_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018
FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
protonephridiaSMED30011381SMESG000066514.1 dd_Smed_v4_2201_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018
FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
nervous systemSMED30011381SMESG000066514.1 dd_Smed_v4_2201_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018
FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
gutSMED30011381SMESG000066514.1 dd_Smed_v4_2201_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018
FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
epidermisSMED30011381SMESG000066514.1 dd_Smed_v4_2201_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018
FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
cephalic gangliaSMED30011381SMESG000066514.1 dd_Smed_v4_2201_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018
FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
muscle cellSMED30011381SMESG000066514.1 dd_Smed_v4_2201_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018
FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
neoblastSMED30011381SMESG000066514.1 dd_Smed_v4_2201_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018
FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
parenchymal cellSMED30011381SMESG000066514.1 dd_Smed_v4_2201_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018
FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
Smed sexual biotypeSMED30011381SMESG000066514.1 Contig10893uc_Smed_v2PMID:29674431
Fincher et al., 2018
FACS sorted cell population adult hermaphrodite single-cell RNA-sequencing evidence
Smed sexual biotypeSMED30011381SMESG000066514.1 Contig10893newmark_estsPMID:29674431
Fincher et al., 2018
FACS sorted cell population adult hermaphrodite single-cell RNA-sequencing evidence
neuronSMED30011381SMESG000066514.1 dd_Smed_v6_2201_0dd_Smed_v6PMID:29674432
Plass et al., 2018
FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
cholinergic neuronSMED30011381SMESG000066514.1 dd_Smed_v6_2201_0dd_Smed_v6PMID:29674432
Plass et al., 2018
FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
pigment cellSMED30011381SMESG000066514.1 dd_Smed_v6_2201_0dd_Smed_v6PMID:29674432
Plass et al., 2018
FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
Note: Hover over icons to view figure legend
Homology
BLAST of HORMA domain-containing protein vs. Ensembl Human
Match: HORMAD1 (HORMA domain containing 1 [Source:HGNC Symbol;Acc:HGNC:25245])

HSP 1 Score: 189.504 bits (480), Expect = 3.089e-54
Identity = 95/242 (39.26%), Postives = 145/242 (59.92%), Query Frame = 1
Query:   28 MPVALLTKEKTWSKMFPTIFTTEQQSLVFMKKLFAVAISNIVYIRSIFPEYAFFDKHLEGIKLKILREDSKCPGASKVINWVRGCFDALDRHYLKAVVIGFYTDIKDPDTVIESYSFKFTYGQDSVSVKLDNTSKTDSGLEAVIKNDDAPETIKKSTLSLLRTLILAGNTQDPLPEKVFVTMKLLYYDEITPDDYEPNGFRTCDYAGFRHETETINAKLGHVETDFHSFRMILKTDKVSFTN 753
            M  A L +    + +FP   +TE QSLV +K+L AV++S I Y+R IFPE A+  ++L+ + +KILRED  CPG+++++ W+ GC+DAL + YL+ VV+  YT+ +DP T+ E Y FKF Y  +     +D  SK  S   +++  D      KK+++ L+R + +      PLP  V +TMKL YYDE+TP DY+P GF+  D  G   E E +   +G V T FH F++ + T++    N
Sbjct:    1 MATAQLQRTPMSALVFPNKISTEHQSLVLVKRLLAVSVSCITYLRGIFPECAYGTRYLDDLCVKILREDKNCPGSTQLVKWMLGCYDALQKKYLRMVVLAVYTNPEDPQTISECYQFKFKYTNNGPL--MDFISKNQSNESSMLSTD-----TKKASILLIRKIYILMQNLGPLPNDVCLTMKLFYYDEVTPPDYQPPGFKDGDCEGVIFEGEPMYLNVGEVSTPFHIFKVKVTTERERMEN 235          
BLAST of HORMA domain-containing protein vs. Ensembl Human
Match: HORMAD2 (HORMA domain containing 2 [Source:HGNC Symbol;Acc:HGNC:28383])

HSP 1 Score: 183.341 bits (464), Expect = 6.781e-53
Identity = 99/273 (36.26%), Postives = 159/273 (58.24%), Query Frame = 1
Query:   70 MFPTIFTTEQQSLVFMKKLFAVAISNIVYIRSIFPEYAFFDKHLEGIKLKILREDSKCPGASKVINWVRGCFDALDRHYLKAVVIGFYTDIKDPDTVIESYSFKFTYGQDSVSVKLDNTSKTDSGLEAVIKNDDAPETIKKSTLSLLRTLILAGNTQDPLPEKVFVTMKLLYYDEITPDDYEPNGFRTCDYAGF-RHETETINAKLGHVETDFHSFRMILKTDK---VSFTNNYVKSSKSSNCNKPEFEKENETPVLNETRKITPNCSRTCSE 876
            +FP+  T E +SL  +KKLFA +IS I Y+R +FPE ++ ++HL+ + LKILRED KCPG+  +I W++GCFDAL++ YL+  V+  YTD    + V E Y FKF Y ++  ++  D+ S + S       N+D    IKK+++ L+R L +     +PLP  V +TMKL YY+ +TP DY+P GF+    + F   + E IN ++G V T FHS ++ + T+    +   NN  + + ++       + + E    +  +++   CS+  SE
Sbjct:   20 VFPSQITNEHESLKMVKKLFATSISCITYLRGLFPESSYGERHLDDLSLKILREDKKCPGSLHIIRWIQGCFDALEKRYLRMAVLTLYTDPMGSEKVTEMYQFKFKYTKEGATMDFDSHSSSTSFESGT-NNED----IKKASVLLIRKLYILMQDLEPLPNNVVLTMKLHYYNAVTPHDYQPLGFKEGVNSHFLLFDKEPINVQVGFVSTGFHSMKVKVMTEATKVIDLENNLFRENSTTEIAHQGLDCDEEEECNDHIQRMNFVCSQQSSE 287          
BLAST of HORMA domain-containing protein vs. Ensembl Human
Match: HORMAD2 (HORMA domain containing 2 [Source:HGNC Symbol;Acc:HGNC:28383])

HSP 1 Score: 183.341 bits (464), Expect = 6.781e-53
Identity = 99/273 (36.26%), Postives = 159/273 (58.24%), Query Frame = 1
Query:   70 MFPTIFTTEQQSLVFMKKLFAVAISNIVYIRSIFPEYAFFDKHLEGIKLKILREDSKCPGASKVINWVRGCFDALDRHYLKAVVIGFYTDIKDPDTVIESYSFKFTYGQDSVSVKLDNTSKTDSGLEAVIKNDDAPETIKKSTLSLLRTLILAGNTQDPLPEKVFVTMKLLYYDEITPDDYEPNGFRTCDYAGF-RHETETINAKLGHVETDFHSFRMILKTDK---VSFTNNYVKSSKSSNCNKPEFEKENETPVLNETRKITPNCSRTCSE 876
            +FP+  T E +SL  +KKLFA +IS I Y+R +FPE ++ ++HL+ + LKILRED KCPG+  +I W++GCFDAL++ YL+  V+  YTD    + V E Y FKF Y ++  ++  D+ S + S       N+D    IKK+++ L+R L +     +PLP  V +TMKL YY+ +TP DY+P GF+    + F   + E IN ++G V T FHS ++ + T+    +   NN  + + ++       + + E    +  +++   CS+  SE
Sbjct:   20 VFPSQITNEHESLKMVKKLFATSISCITYLRGLFPESSYGERHLDDLSLKILREDKKCPGSLHIIRWIQGCFDALEKRYLRMAVLTLYTDPMGSEKVTEMYQFKFKYTKEGATMDFDSHSSSTSFESGT-NNED----IKKASVLLIRKLYILMQDLEPLPNNVVLTMKLHYYNAVTPHDYQPLGFKEGVNSHFLLFDKEPINVQVGFVSTGFHSMKVKVMTEATKVIDLENNLFRENSTTEIAHQGLDCDEEEECNDHIQRMNFVCSQQSSE 287          
BLAST of HORMA domain-containing protein vs. Ensembl Human
Match: HORMAD1 (HORMA domain containing 1 [Source:HGNC Symbol;Acc:HGNC:25245])

HSP 1 Score: 176.407 bits (446), Expect = 2.446e-49
Identity = 92/242 (38.02%), Postives = 141/242 (58.26%), Query Frame = 1
Query:   28 MPVALLTKEKTWSKMFPTIFTTEQQSLVFMKKLFAVAISNIVYIRSIFPEYAFFDKHLEGIKLKILREDSKCPGASKVINWVRGCFDALDRHYLKAVVIGFYTDIKDPDTVIESYSFKFTYGQDSVSVKLDNTSKTDSGLEAVIKNDDAPETIKKSTLSLLRTLILAGNTQDPLPEKVFVTMKLLYYDEITPDDYEPNGFRTCDYAGFRHETETINAKLGHVETDFHSFRMILKTDKVSFTN 753
            M  A L +    + +FP   +TE QSLV +K+L AV++S I Y+R IFPE A+  ++L+ + +KILRED  CPG+++++ W+ GC+DAL + Y+       YT+ +DP T+ E Y FKF Y  +     +D  SK  S   +++  D      KK+++ L+R + +      PLP  V +TMKL YYDE+TP DY+P GF+  D  G   E E +   +G V T FH F++ + T++    N
Sbjct:    1 MATAQLQRTPMSALVFPNKISTEHQSLVLVKRLLAVSVSCITYLRGIFPECAYGTRYLDDLCVKILREDKNCPGSTQLVKWMLGCYDALQKKYV-------YTNPEDPQTISECYQFKFKYTNNGPL--MDFISKNQSNESSMLSTD-----TKKASILLIRKIYILMQNLGPLPNDVCLTMKLFYYDEVTPPDYQPPGFKDGDCEGVIFEGEPMYLNVGEVSTPFHIFKVKVTTERERMEN 228          
BLAST of HORMA domain-containing protein vs. Ensembl Human
Match: HORMAD1 (HORMA domain containing 1 [Source:HGNC Symbol;Acc:HGNC:25245])

HSP 1 Score: 119.398 bits (298), Expect = 1.177e-30
Identity = 62/167 (37.13%), Postives = 94/167 (56.29%), Query Frame = 1
Query:  253 SKVINWVRGCFDALDRHYLKAVVIGFYTDIKDPDTVIESYSFKFTYGQDSVSVKLDNTSKTDSGLEAVIKNDDAPETIKKSTLSLLRTLILAGNTQDPLPEKVFVTMKLLYYDEITPDDYEPNGFRTCDYAGFRHETETINAKLGHVETDFHSFRMILKTDKVSFTN 753
            +K+  W+ GC+DAL + YL+ VV+  YT+ +DP T+ E Y FKF Y  +     +D  SK  S   +++  D      KK+++ L+R + +      PLP  V +TMKL YYDE+TP DY+P GF+  D  G   E E +   +G V T FH F++ + T++    N
Sbjct:    5 NKISRWMLGCYDALQKKYLRMVVLAVYTNPEDPQTISECYQFKFKYTNNGPL--MDFISKNQSNESSMLSTD-----TKKASILLIRKIYILMQNLGPLPNDVCLTMKLFYYDEVTPPDYQPPGFKDGDCEGVIFEGEPMYLNVGEVSTPFHIFKVKVTTERERMEN 164          
BLAST of HORMA domain-containing protein vs. Ensembl Celegans
Match: him-3 (High Incidence of Males (Increased X chromosome loss); Meiotic chromosome core protein [Source:UniProtKB/TrEMBL;Acc:G5EBG0])

HSP 1 Score: 62.7734 bits (151), Expect = 1.296e-10
Identity = 51/194 (26.29%), Postives = 86/194 (44.33%), Query Frame = 1
Query:   61 WSKMFPTIFTTEQQSLVFMKKLFAVAISNIVYIRSIFPEYAFFDKHLEGIKLKILREDSKCPGASKVINWVRGCFDALDRHYLKAVVIGFYTDIKDPDTVIESYSFKFTYGQD-----SVSVKLDNTSKTDSGLEAVIKNDDAPETIKKSTLSLLRTLILAGNTQDPLPEKVFVTMKLLYYDEITPDDYEPNGF 627
            W   FP     E+ S +F  +    A + I+  R I  E  F  + ++  KL +    S  P A +V +   G  DA+ + YL+   I FY    + D + E ++F+F YG +     S++  +D    +   L+A   + D  + +  ST+  L   I      +PLP+    + + + Y E  P DY P G+
Sbjct:   21 WKATFPVDLEIEKNSEMFALRYIKCASAFILDRRGILDEKCFKTRTID--KLLVTAFQSSVPAAKRVSSTFDGLRDAIQQGYLREFAIVFYKKPNEED-INEVFAFRFAYGDEGEIFVSLNNGIDTNESSQELLQAKFVDTDNTKQMFASTIKKLHRCI---KKMEPLPQGSDASFR-VSYTEKAPKDYTPEGY 207          
BLAST of HORMA domain-containing protein vs. Ensembl Celegans
Match: him-3 (High Incidence of Males (Increased X chromosome loss); Meiotic chromosome core protein [Source:UniProtKB/TrEMBL;Acc:G5EBG0])

HSP 1 Score: 62.7734 bits (151), Expect = 1.296e-10
Identity = 51/194 (26.29%), Postives = 86/194 (44.33%), Query Frame = 1
Query:   61 WSKMFPTIFTTEQQSLVFMKKLFAVAISNIVYIRSIFPEYAFFDKHLEGIKLKILREDSKCPGASKVINWVRGCFDALDRHYLKAVVIGFYTDIKDPDTVIESYSFKFTYGQD-----SVSVKLDNTSKTDSGLEAVIKNDDAPETIKKSTLSLLRTLILAGNTQDPLPEKVFVTMKLLYYDEITPDDYEPNGF 627
            W   FP     E+ S +F  +    A + I+  R I  E  F  + ++  KL +    S  P A +V +   G  DA+ + YL+   I FY    + D + E ++F+F YG +     S++  +D    +   L+A   + D  + +  ST+  L   I      +PLP+    + + + Y E  P DY P G+
Sbjct:   21 WKATFPVDLEIEKNSEMFALRYIKCASAFILDRRGILDEKCFKTRTID--KLLVTAFQSSVPAAKRVSSTFDGLRDAIQQGYLREFAIVFYKKPNEED-INEVFAFRFAYGDEGEIFVSLNNGIDTNESSQELLQAKFVDTDNTKQMFASTIKKLHRCI---KKMEPLPQGSDASFR-VSYTEKAPKDYTPEGY 207          
BLAST of HORMA domain-containing protein vs. Ensembl Celegans
Match: htp-1 (Him-Three Paralog [Source:UniProtKB/TrEMBL;Acc:Q20305])

HSP 1 Score: 61.2326 bits (147), Expect = 6.825e-10
Identity = 57/231 (24.68%), Postives = 111/231 (48.05%), Query Frame = 1
Query:   52 EKTWSKMFPTIFTTEQQSLVFMKKLFAVAISNIVYIRSIFPEYAFFDKHLEGIKLKILREDSKCPGASKVINWVRGCFDALDRHYLKAVVIGFYTDIKDPDTVIESYSFKFTYGQDSVSVKLDNTSKTD------SGLEAVIKNDDAPETIKKSTLSLLRTL-ILAGNTQDPLPEKVFVTMKLLYYDEITPDDYEPNGFRTCDYAGFRHETETI-NAKLGHVETDFHSFRM 720
            +K WSK+FP I +   +S  FM +   VA S ++  R+I  +  +F K+    KLK +    + P ++++   +R   DA    +LK V +    +  D +  IE +S KF Y ++   V   +T K        + L  ++   +  ++++   ++++R++  L     +PLPE+     +L Y ++  P ++  +GF   D + F    + I +A +GH+    H+  M
Sbjct:   21 DKKWSKLFPRIVSDPDRSSNFMTRAIYVAFSAVLRNRNILGQ-EYFTKNYITEKLKCMTLCFRNPRSNQIAQLLRNAGDATKDGFLKEVSLVITNNEGDLE-AIEVFSMKFIYFENGGVVARLSTDKNGQEDPHFAKLAQLVY--EGGDSVRDQMVTIVRSVQFLCTKVLEPLPEEFTANFRLEYTND-APSNFRIDGFE--DSSTFYTLPDDIQSATIGHLRPGCHAANM 244          
BLAST of HORMA domain-containing protein vs. Ensembl Celegans
Match: htp-2 (Him-Three Paralog [Source:UniProtKB/TrEMBL;Acc:Q95XC8])

HSP 1 Score: 57.3806 bits (137), Expect = 9.681e-9
Identity = 54/229 (23.58%), Postives = 104/229 (45.41%), Query Frame = 1
Query:   52 EKTWSKMFPTIFTTEQQSLVFMKKLFAVAISNIVYIRSIFPEYAFFDKHLEGIKLKILREDSKCPGASKVINWVRGCFDALDRHYLKAVVIGFYTDIKDPDTVIESYSFKFTYGQDS---VSVKLDNTSKTDSGLEAVIK-NDDAPETIKKSTLSLLRTL-ILAGNTQDPLPEKVFVTMKLLYYDEITPDDYEPNGFRTCDYAGFRHETETINA-KLGHVETDFHSFRM 720
            +KTWSK+FP+I +   +S  FM +   V  S ++  R+I  E  +F K+     L  +    K   A ++   +R   DA    +LK + +   T+       IE +S KF Y ++      +  DN  + D     + +   +  E+++   ++++R++  L     +PLP +     +L Y ++  P ++  +GF   D + F    + I +  +GH+    H+  M
Sbjct:   21 DKTWSKLFPSIVSDPDRSSNFMIRAIYVVFSAVLRQRNIL-EKEYFSKNYITENLSCMTLSFKNLRAHQIAQLLRAAGDATKDGFLKEISL-VVTEHDGDVEAIEVFSMKFIYFENGGVVARLSTDNNDQEDPHFAELAQLRYEGAESVRDQMVTIVRSVQFLCTKVLEPLPAEFTANFRLKYTND-APSNFRIDGFD--DSSTFYTLPDGIQSVTIGHLRPGHHAAHM 244          
BLAST of HORMA domain-containing protein vs. Ensembl Celegans
Match: set-9 (Histone-lysine N-methyltransferase set-9 [Source:UniProtKB/Swiss-Prot;Acc:O44498])

HSP 1 Score: 49.2914 bits (116), Expect = 7.407e-6
Identity = 20/52 (38.46%), Postives = 30/52 (57.69%), Query Frame = 1
Query:  871 SEEEFFVRCPCGGNKDDGIMIMCENCKNWQHSICFGIIEEDRVPEVHVCDIC 1026
            +EE + +RC CG +  DG  I CE CK WQH  C G+  +    + + C++C
Sbjct:  781 AEESWTMRCHCGMDHGDGDTIECEGCKTWQHMACMGLTLKSNTSK-YKCEMC 831          
BLAST of HORMA domain-containing protein vs. Ensembl Fly
Match: MBD-R2 (gene:FBgn0038016 transcript:FBtr0082611)

HSP 1 Score: 64.3142 bits (155), Expect = 2.402e-10
Identity = 38/132 (28.79%), Postives = 65/132 (49.24%), Query Frame = 1
Query:  877 EEFFVRCPCGGNKDDGIMIMCENCKNWQHSICFGIIEEDRVPEVHVCDICADANPNLKATDIKLKE-----FNEDRQVILFHNLFIKPLKEICLIRRALIYCKSSDVIEPGQLADVLGVEINVGKGVFHTLL 1257
            +E  + C C   ++DG+MI CE C  WQH  C GI++E  VP+ +VC IC   NP      ++ K      F     V  +H    +  K+  L++R+  +  + ++++  +    L V+IN+ +   H  L
Sbjct:  914 QEEIINCICEYGEEDGLMIQCELCLCWQHGACNGIVKEADVPDKYVCYIC--RNPQRGRDSMRFKHDQDWLFEGKLPVAAYHTANPQATKQFELLKRS--HTLTGNLLDAKRSMHSLLVKINIARNRCHPKL 1041          
BLAST of HORMA domain-containing protein vs. Ensembl Fly
Match: upSET (gene:FBgn0036398 transcript:FBtr0333050)

HSP 1 Score: 52.373 bits (124), Expect = 1.221e-6
Identity = 20/45 (44.44%), Postives = 27/45 (60.00%), Query Frame = 1
Query:  892 RCPCGGNKDDGIMIMCENCKNWQHSICFGIIEEDRVPEVHVCDIC 1026
            RC C    DDG MI C+ C  WQH  C G I+   +PE ++C++C
Sbjct:  856 RCICELTHDDGYMICCDKCSAWQHVDCMG-IDRQNIPEEYMCELC 899          
BLAST of HORMA domain-containing protein vs. Ensembl Fly
Match: upSET (gene:FBgn0036398 transcript:FBtr0075768)

HSP 1 Score: 52.373 bits (124), Expect = 1.221e-6
Identity = 20/45 (44.44%), Postives = 27/45 (60.00%), Query Frame = 1
Query:  892 RCPCGGNKDDGIMIMCENCKNWQHSICFGIIEEDRVPEVHVCDIC 1026
            RC C    DDG MI C+ C  WQH  C G I+   +PE ++C++C
Sbjct:  856 RCICELTHDDGYMICCDKCSAWQHVDCMG-IDRQNIPEEYMCELC 899          
BLAST of HORMA domain-containing protein vs. Ensembl Fly
Match: ash1 (gene:FBgn0005386 transcript:FBtr0306009)

HSP 1 Score: 49.6766 bits (117), Expect = 8.552e-6
Identity = 30/94 (31.91%), Postives = 46/94 (48.94%), Query Frame = 1
Query:  805 KENETPVLNETRKITPNCSRTCSEEEFFVRCPCGGNKDDGIMIMCENCKNWQHSICFGIIEEDRVPEVHVCDICADANPNLKATDIKLKEFNED 1086
            KE ++P++       P      S +E  +RC CG  KD+G+MI C  C  WQH+ C    + D   + + C+ C    P     +I L+EF E+
Sbjct: 1830 KERDSPIVPLKVTPPPLLPIEASPDEDVIRCICGLYKDEGLMIQCSKCMVWQHTEC---TKADIDADNYQCERC---EPREVDREIPLEEFTEE 1917          
BLAST of HORMA domain-containing protein vs. Ensembl Fly
Match: ash1 (gene:FBgn0005386 transcript:FBtr0306010)

HSP 1 Score: 49.6766 bits (117), Expect = 8.552e-6
Identity = 30/94 (31.91%), Postives = 46/94 (48.94%), Query Frame = 1
Query:  805 KENETPVLNETRKITPNCSRTCSEEEFFVRCPCGGNKDDGIMIMCENCKNWQHSICFGIIEEDRVPEVHVCDICADANPNLKATDIKLKEFNED 1086
            KE ++P++       P      S +E  +RC CG  KD+G+MI C  C  WQH+ C    + D   + + C+ C    P     +I L+EF E+
Sbjct: 1830 KERDSPIVPLKVTPPPLLPIEASPDEDVIRCICGLYKDEGLMIQCSKCMVWQHTEC---TKADIDADNYQCERC---EPREVDREIPLEEFTEE 1917          
BLAST of HORMA domain-containing protein vs. Ensembl Zebrafish
Match: hormad1 (HORMA domain containing 1 [Source:NCBI gene;Acc:436630])

HSP 1 Score: 187.578 bits (475), Expect = 4.804e-54
Identity = 94/224 (41.96%), Postives = 138/224 (61.61%), Query Frame = 1
Query:   67 KMFPTIFTTEQQSLVFMKKLFAVAISNIVYIRSIFPEYAFFDKHLEGIKLKILREDSKCPGASKVINWVRGCFDALDRHYLKAVVIGFYTDIKDPDTVIESYSFKFTYGQDSVSVKLDNTSKTDSGLEAVIKNDDAPETIKKSTLSLLRTLILAGNTQDPLPEKVFVTMKLLYYDEITPDDYEPNGFRTCDYAGFRHETETINAKLGHVETDFHSFRMILKTDK 738
            +M P + + EQQSLV +KKL A+AIS+I Y+R +F E A+  K++  +K+ ILREDS CPGA ++++W++GCFDAL R YL+ V++  Y D  +P  V E Y FK  Y +     ++D  SK    L  +     A +  +KS++ L+R L +      PLP+ V + MKLLYYDE+TP +Y+P GF+  D      E E +N  +G V T FHS +M + T+K
Sbjct:   14 QMLPDVVSNEQQSLVLVKKLLAIAISSITYLRGLFSEKAYGRKYVGELKVYILREDS-CPGAQQIVHWLQGCFDALQRRYLRMVLLSIYCDPDNPQKVTECYQFKIKYTEKGP--QMDFESKNGQSLTKM-----ACDNTQKSSMLLVRKLYMLMQNLGPLPDDVCLNMKLLYYDEVTPQEYQPPGFKEDDNGTLMFEREPVNLTMGEVVTPFHSIKMNVTTEK 229          
BLAST of HORMA domain-containing protein vs. Ensembl Zebrafish
Match: zte38 (zebrafish testis-expressed 38 [Source:ZFIN;Acc:ZDB-GENE-060312-39])

HSP 1 Score: 165.236 bits (417), Expect = 2.807e-46
Identity = 87/250 (34.80%), Postives = 140/250 (56.00%), Query Frame = 1
Query:   91 TEQQSLVFMKKLFAVAISNIVYIRSIFPEYAFFDKHLEGIKLKILREDSKCPGASKVINWVRGCFDALDRHYLKAVVIGFYTDIKDPDTVIESYSFKFTYGQDSVSVKLDNTSKTDSGLEAVIKNDDAPETIKKSTLSLLRTLILAGNTQDPLPEKVFVTMKLLYYDEITPDDYEPNGFRTCDYAGFRHETETINAKLGHVETDFHSFRMILKTDKVSFTNNYVKSSKSSNCNKPEFEKENETPVLNETR 840
            TE QSLVF+K++  +A+S+I Y+R IFPE ++  ++LE + +K+L++D   PGA K+I W+ GCFDAL++ YL+ +VIG +T   D + VIESY FKF Y +     ++D  S  +  +   +      E  KK++  L+R L L     + LP  V +TMKL Y D++TP +YEP GF+         E   ++ ++G +++ +H+ ++ +   +            S N      E E ETP L+  R
Sbjct:   21 TEAQSLVFVKRMVVIAVSSITYLRGIFPEDSYRSRYLEDLCIKVLKQDCSSPGAHKLIKWLMGCFDALEKRYLQMLVIGVHTSPHDSNHVIESYQFKFRYSEH--GPQMDILSNVNGDIRVTL------EDTKKASTLLIRKLFLLMQNLEALPTAVHLTMKLYYNDDVTPPEYEPPGFKAGANESLWFEGTAVHFRVGDLQSRYHTMKLRVTAAQSRLGKLQDGGQLSEN------EMEMETPSLHHIR 256          
BLAST of HORMA domain-containing protein vs. Ensembl Zebrafish
Match: phf20l1 (PHD finger protein 20 like 1 [Source:ZFIN;Acc:ZDB-GENE-030131-5837])

HSP 1 Score: 62.3882 bits (150), Expect = 9.652e-10
Identity = 24/49 (48.98%), Postives = 34/49 (69.39%), Query Frame = 1
Query:  886 FVRCPCGGNKDDGIMIMCENCKNWQHSICFGIIEEDRVPEVHVCDICAD 1032
             VRC C  ++++G MI CE C  WQHS+C G++ ED +PE ++C IC D
Sbjct:  821 IVRCICEMDEENGFMIQCEECMCWQHSVCMGLL-EDSIPEQYICYICRD 868          
BLAST of HORMA domain-containing protein vs. Ensembl Zebrafish
Match: phf20l1 (PHD finger protein 20 like 1 [Source:ZFIN;Acc:ZDB-GENE-030131-5837])

HSP 1 Score: 62.003 bits (149), Expect = 1.227e-9
Identity = 24/49 (48.98%), Postives = 34/49 (69.39%), Query Frame = 1
Query:  886 FVRCPCGGNKDDGIMIMCENCKNWQHSICFGIIEEDRVPEVHVCDICAD 1032
             VRC C  ++++G MI CE C  WQHS+C G++ ED +PE ++C IC D
Sbjct:  693 IVRCICEMDEENGFMIQCEECMCWQHSVCMGLL-EDSIPEQYICYICRD 740          
BLAST of HORMA domain-containing protein vs. Ensembl Zebrafish
Match: phf20a (PHD finger protein 20, a [Source:ZFIN;Acc:ZDB-GENE-070912-270])

HSP 1 Score: 58.9214 bits (141), Expect = 1.224e-8
Identity = 32/88 (36.36%), Postives = 48/88 (54.55%), Query Frame = 1
Query:  775 SSNCNKPEFEKENETPVLNETRKITPNCSRTCSEEEFFVRCPCGGNKDDGIMIMCENCKNWQHSICFGIIEEDRVPEVHVCDICADAN 1038
            S +C   E E E +  V+      +   S T S+E   VRC C  ++++  M+ CE C  WQH  C G++EE+ VPE + C IC D++
Sbjct:  558 SESCGWSEDEMEADLDVITSPLSCSSVASTTESQE--TVRCVCEADEENDFMLQCEECLYWQHGTCMGLLEEN-VPERYSCFICRDSS 642          
BLAST of HORMA domain-containing protein vs. Ensembl Xenopus
Match: gstm1 (glutathione S-transferase mu 1 [Source:Xenbase;Acc:XB-GENE-971384])

HSP 1 Score: 162.925 bits (411), Expect = 8.356e-45
Identity = 86/223 (38.57%), Postives = 129/223 (57.85%), Query Frame = 1
Query:   70 MFPTIFTTEQQSLVFMKKLFAVAISNIVYIRSIFPEYAFFDKHLEGIKLKILREDSKCPGASKVINWVRGCFDALDRHYLKAVVIGFYTDIKDPDTVIESYSFKFTYGQDSVSVKLDNTSKTDSGLEAVIKNDDAPETIKKSTLSLLRTLILAGNTQDPLPEKVFVTMKLLYYDEITPDDYEPNGFRTCDYAGFRHETETINAKLGHVETDFHSFRMILKTDK 738
            + P   TTE QSLV +K+L AV++S I Y+R +FPEYA+  ++LE I +KILRED  CPG+++++ W+ GC+DAL + Y                TV E Y FKF Y   +    +D  S  ++G    I +D     +K++++ L+R L +      PLP  V++TMKL YYDE+TP DY+P GF+  +  G   E E +   +G V T FH  ++ + T+K
Sbjct:   15 ILPNRVTTETQSLVLVKRLLAVSVSCITYLRGLFPEYAYGTRYLEDICVKILREDKSCPGSTQLVKWMLGCYDALQKKY----------------TVTECYQFKFKY--TAFGPTMDFVS--NNGSSTSICSD-----VKRTSVMLIRKLYVLMQNLGPLPNDVYLTMKLFYYDEVTPADYQPPGFKEGNCEGLMFEGEPMYLNVGEVATPFHVLKVKVTTEK 212          
BLAST of HORMA domain-containing protein vs. Ensembl Xenopus
Match: PHF20L1 (PHD finger protein 20 like 1 [Source:NCBI gene;Acc:100145157])

HSP 1 Score: 60.8474 bits (146), Expect = 3.925e-9
Identity = 25/48 (52.08%), Postives = 34/48 (70.83%), Query Frame = 1
Query:  889 VRCPCGGNKDDGIMIMCENCKNWQHSICFGIIEEDRVPEVHVCDICAD 1032
            VRC C  ++++G MI CE C  WQHS C G++EE  +PE +VC IC+D
Sbjct:  560 VRCVCEIDEENGFMIQCEECLCWQHSACMGLLEES-IPEQYVCYICSD 606          
BLAST of HORMA domain-containing protein vs. Ensembl Xenopus
Match: PHF20L1 (PHD finger protein 20 like 1 [Source:NCBI gene;Acc:100145157])

HSP 1 Score: 60.8474 bits (146), Expect = 5.003e-9
Identity = 25/49 (51.02%), Postives = 34/49 (69.39%), Query Frame = 1
Query:  886 FVRCPCGGNKDDGIMIMCENCKNWQHSICFGIIEEDRVPEVHVCDICAD 1032
             VRC C  ++++G MI CE C  WQHS C G++EE  +PE +VC IC+D
Sbjct:  571 IVRCVCEIDEENGFMIQCEECLCWQHSACMGLLEES-IPEQYVCYICSD 618          
BLAST of HORMA domain-containing protein vs. Ensembl Xenopus
Match: PHF20 (PHD finger protein 20 [Source:NCBI gene;Acc:100126218])

HSP 1 Score: 55.4546 bits (132), Expect = 2.026e-7
Identity = 23/49 (46.94%), Postives = 29/49 (59.18%), Query Frame = 1
Query:  886 FVRCPCGGNKDDGIMIMCENCKNWQHSICFGIIEEDRVPEVHVCDICAD 1032
             VRC C    ++  MI CE C  WQH +C G++ ED VPE + C IC D
Sbjct:  634 IVRCMCEVQDENDFMIQCEECLCWQHGVCMGLL-EDNVPEKYKCYICQD 681          
BLAST of HORMA domain-containing protein vs. Ensembl Xenopus
Match: KMT2E (lysine (K)-specific methyltransferase 2E [Source:NCBI gene;Acc:779539])

HSP 1 Score: 52.7582 bits (125), Expect = 1.179e-6
Identity = 20/46 (43.48%), Postives = 28/46 (60.87%), Query Frame = 1
Query:  889 VRCPCGGNKDDGIMIMCENCKNWQHSICFGIIEEDRVPEVHVCDIC 1026
             RC CG   DDG MI C+ C  WQH  C G I+   +P++++C+ C
Sbjct:   99 TRCICGFTHDDGYMICCDKCSVWQHIDCMG-IDRQNIPDIYLCERC 143          
BLAST of HORMA domain-containing protein vs. Ensembl Mouse
Match: Hormad2 (HORMA domain containing 2 [Source:MGI Symbol;Acc:MGI:1923078])

HSP 1 Score: 183.341 bits (464), Expect = 4.822e-53
Identity = 91/224 (40.62%), Postives = 140/224 (62.50%), Query Frame = 1
Query:   70 MFPTIFTTEQQSLVFMKKLFAVAISNIVYIRSIFPEYAFFDKHLEGIKLKILREDSKCPGASKVINWVRGCFDALDRHYLKAVVIGFYTDIKDPDTVIESYSFKFTYGQDSVSVKLDNTSKT-DSGLEAVIKNDDAPETIKKSTLSLLRTLILAGNTQDPLPEKVFVTMKLLYYDEITPDDYEPNGFRTCDYAGF-RHETETINAKLGHVETDFHSFRMILKTD 735
            +FP+  T E +SLV +KKLFA  IS I Y+R +FPE ++ D+ L+ + LKILRED KCPG+  +I W++GCFDAL++ YL   V+  YT+ K+P+ V E Y F+F Y +   ++  D++S + +SG ++        E IKK+   L+R L +      PLP  V +TMKL YY+ +TP DY+P GF+    + F   E E ++ ++G V + FHS ++ + T+
Sbjct:   20 IFPSQVTNEHESLVVVKKLFATCISCITYLRGLFPESSYRDRRLDDLSLKILREDKKCPGSLHIIKWIQGCFDALEKRYLHMAVLTLYTNPKEPEKVTEIYQFRFKYTKKGTTMDFDSSSTSFESGTDS--------EDIKKACSLLIRQLYILMQNLGPLPNDVILTMKLHYYNSVTPHDYQPPGFKEAVNSHFLLFEGEPVSLRMGSVSSGFHSMKVKVTTE 235          
BLAST of HORMA domain-containing protein vs. Ensembl Mouse
Match: Hormad2 (HORMA domain containing 2 [Source:MGI Symbol;Acc:MGI:1923078])

HSP 1 Score: 183.341 bits (464), Expect = 4.822e-53
Identity = 91/224 (40.62%), Postives = 140/224 (62.50%), Query Frame = 1
Query:   70 MFPTIFTTEQQSLVFMKKLFAVAISNIVYIRSIFPEYAFFDKHLEGIKLKILREDSKCPGASKVINWVRGCFDALDRHYLKAVVIGFYTDIKDPDTVIESYSFKFTYGQDSVSVKLDNTSKT-DSGLEAVIKNDDAPETIKKSTLSLLRTLILAGNTQDPLPEKVFVTMKLLYYDEITPDDYEPNGFRTCDYAGF-RHETETINAKLGHVETDFHSFRMILKTD 735
            +FP+  T E +SLV +KKLFA  IS I Y+R +FPE ++ D+ L+ + LKILRED KCPG+  +I W++GCFDAL++ YL   V+  YT+ K+P+ V E Y F+F Y +   ++  D++S + +SG ++        E IKK+   L+R L +      PLP  V +TMKL YY+ +TP DY+P GF+    + F   E E ++ ++G V + FHS ++ + T+
Sbjct:   20 IFPSQVTNEHESLVVVKKLFATCISCITYLRGLFPESSYRDRRLDDLSLKILREDKKCPGSLHIIKWIQGCFDALEKRYLHMAVLTLYTNPKEPEKVTEIYQFRFKYTKKGTTMDFDSSSTSFESGTDS--------EDIKKACSLLIRQLYILMQNLGPLPNDVILTMKLHYYNSVTPHDYQPPGFKEAVNSHFLLFEGEPVSLRMGSVSSGFHSMKVKVTTE 235          
BLAST of HORMA domain-containing protein vs. Ensembl Mouse
Match: Hormad1 (HORMA domain containing 1 [Source:MGI Symbol;Acc:MGI:1915231])

HSP 1 Score: 184.882 bits (468), Expect = 8.416e-53
Identity = 91/233 (39.06%), Postives = 139/233 (59.66%), Query Frame = 1
Query:   70 MFPTIFTTEQQSLVFMKKLFAVAISNIVYIRSIFPEYAFFDKHLEGIKLKILREDSKCPGASKVINWVRGCFDALDRHYLKAVVIGFYTDIKDPDTVIESYSFKFTYGQ-----DSVSVKLDNTSKTDSGLEAVIKNDDAPETIKKSTLSLLRTLILAGNTQDPLPEKVFVTMKLLYYDEITPDDYEPNGFRTCDYAGFRHETETINAKLGHVETDFHSFRMILKTDKVSFTN 753
            +FP   +TE QSL+F+K+L AV++S I Y+R IFPE A+  ++L+ + +KIL+ED  CPG+S+++ W+ GC+DAL + YL+ +++  YT+  DP T+ E Y FKF Y +     D +S   +N S T S               KK+++ L+R + +      PLP  V +TMKL YYDE+TP DY+P GF+  D  G   + +     +G V T FH+FR+ + T+K    N
Sbjct:   16 VFPNKISTEHQSLMFVKRLLAVSVSCITYLRGIFPERAYGTRYLDDLCVKILKEDKNCPGSSQLVKWMLGCYDALQKKYLRMIILAVYTNPGDPQTISECYQFKFKYTKNGPIMDFISKNQNNKSSTTSA------------DTKKASILLIRKIYVLMQNLGPLPNDVCLTMKLFYYDEVTPPDYQPPGFKDGDCEGVIFDGDPTYLNVGEVPTPFHTFRLKVTTEKERMEN 236          
BLAST of HORMA domain-containing protein vs. Ensembl Mouse
Match: Hormad1 (HORMA domain containing 1 [Source:MGI Symbol;Acc:MGI:1915231])

HSP 1 Score: 184.882 bits (468), Expect = 8.416e-53
Identity = 91/233 (39.06%), Postives = 139/233 (59.66%), Query Frame = 1
Query:   70 MFPTIFTTEQQSLVFMKKLFAVAISNIVYIRSIFPEYAFFDKHLEGIKLKILREDSKCPGASKVINWVRGCFDALDRHYLKAVVIGFYTDIKDPDTVIESYSFKFTYGQ-----DSVSVKLDNTSKTDSGLEAVIKNDDAPETIKKSTLSLLRTLILAGNTQDPLPEKVFVTMKLLYYDEITPDDYEPNGFRTCDYAGFRHETETINAKLGHVETDFHSFRMILKTDKVSFTN 753
            +FP   +TE QSL+F+K+L AV++S I Y+R IFPE A+  ++L+ + +KIL+ED  CPG+S+++ W+ GC+DAL + YL+ +++  YT+  DP T+ E Y FKF Y +     D +S   +N S T S               KK+++ L+R + +      PLP  V +TMKL YYDE+TP DY+P GF+  D  G   + +     +G V T FH+FR+ + T+K    N
Sbjct:   16 VFPNKISTEHQSLMFVKRLLAVSVSCITYLRGIFPERAYGTRYLDDLCVKILKEDKNCPGSSQLVKWMLGCYDALQKKYLRMIILAVYTNPGDPQTISECYQFKFKYTKNGPIMDFISKNQNNKSSTTSA------------DTKKASILLIRKIYVLMQNLGPLPNDVCLTMKLFYYDEVTPPDYQPPGFKDGDCEGVIFDGDPTYLNVGEVPTPFHTFRLKVTTEKERMEN 236          
BLAST of HORMA domain-containing protein vs. Ensembl Mouse
Match: Hormad1 (HORMA domain containing 1 [Source:MGI Symbol;Acc:MGI:1915231])

HSP 1 Score: 184.882 bits (468), Expect = 8.416e-53
Identity = 91/233 (39.06%), Postives = 139/233 (59.66%), Query Frame = 1
Query:   70 MFPTIFTTEQQSLVFMKKLFAVAISNIVYIRSIFPEYAFFDKHLEGIKLKILREDSKCPGASKVINWVRGCFDALDRHYLKAVVIGFYTDIKDPDTVIESYSFKFTYGQ-----DSVSVKLDNTSKTDSGLEAVIKNDDAPETIKKSTLSLLRTLILAGNTQDPLPEKVFVTMKLLYYDEITPDDYEPNGFRTCDYAGFRHETETINAKLGHVETDFHSFRMILKTDKVSFTN 753
            +FP   +TE QSL+F+K+L AV++S I Y+R IFPE A+  ++L+ + +KIL+ED  CPG+S+++ W+ GC+DAL + YL+ +++  YT+  DP T+ E Y FKF Y +     D +S   +N S T S               KK+++ L+R + +      PLP  V +TMKL YYDE+TP DY+P GF+  D  G   + +     +G V T FH+FR+ + T+K    N
Sbjct:   16 VFPNKISTEHQSLMFVKRLLAVSVSCITYLRGIFPERAYGTRYLDDLCVKILKEDKNCPGSSQLVKWMLGCYDALQKKYLRMIILAVYTNPGDPQTISECYQFKFKYTKNGPIMDFISKNQNNKSSTTSA------------DTKKASILLIRKIYVLMQNLGPLPNDVCLTMKLFYYDEVTPPDYQPPGFKDGDCEGVIFDGDPTYLNVGEVPTPFHTFRLKVTTEKERMEN 236          
BLAST of HORMA domain-containing protein vs. UniProt/SwissProt
Match: sp|Q2KIY6|HORM1_BOVIN (HORMA domain-containing protein 1 OS=Bos taurus OX=9913 GN=HORMAD1 PE=2 SV=2)

HSP 1 Score: 191.815 bits (486), Expect = 2.049e-54
Identity = 97/242 (40.08%), Postives = 146/242 (60.33%), Query Frame = 1
Query:   28 MPVALLTKEKTWSKMFPTIFTTEQQSLVFMKKLFAVAISNIVYIRSIFPEYAFFDKHLEGIKLKILREDSKCPGASKVINWVRGCFDALDRHYLKAVVIGFYTDIKDPDTVIESYSFKFTYGQDSVSVKLDNTSKTDSGLEAVIKNDDAPETIKKSTLSLLRTLILAGNTQDPLPEKVFVTMKLLYYDEITPDDYEPNGFRTCDYAGFRHETETINAKLGHVETDFHSFRMILKTDKVSFTN 753
            M  A L +    + +FP   +TEQQSLV +K+L AV++S I Y+R IFPE A+  ++L+ + +KILRED  CPG+++++ W+ GC+DAL + YL+ VV+  YT+ +DP T+ E Y FKF Y  +     +D TSK  S    +   D      KK+++ L+R + +      PLP  V +TMKL YYDE+TP DY+P GF+  D  G   E E +   +G V T FH+F++ + T++    N
Sbjct:    1 MATAQLQRTSMSALIFPNKISTEQQSLVLVKRLLAVSVSCITYLRGIFPECAYGTRYLDDLCVKILREDKNCPGSTQLVKWMLGCYDALHKKYLRMVVLAVYTNPEDPQTISECYQFKFKYTSNGPV--MDFTSKNQSNEPNMSSAD-----TKKASILLIRKIYILMQNLGPLPNDVCLTMKLFYYDEVTPPDYQPPGFKDGDCEGVIFEGEPMYLNVGEVPTPFHTFKVKVTTERERMEN 235          
BLAST of HORMA domain-containing protein vs. UniProt/SwissProt
Match: sp|A6QQY4|HORM2_BOVIN (HORMA domain-containing protein 2 OS=Bos taurus OX=9913 GN=HORMAD2 PE=2 SV=1)

HSP 1 Score: 189.119 bits (479), Expect = 2.136e-54
Identity = 89/223 (39.91%), Postives = 142/223 (63.68%), Query Frame = 1
Query:   70 MFPTIFTTEQQSLVFMKKLFAVAISNIVYIRSIFPEYAFFDKHLEGIKLKILREDSKCPGASKVINWVRGCFDALDRHYLKAVVIGFYTDIKDPDTVIESYSFKFTYGQDSVSVKLDNTSKTDSGLEAVIKNDDAPETIKKSTLSLLRTLILAGNTQDPLPEKVFVTMKLLYYDEITPDDYEPNGFRTCDYAG-FRHETETINAKLGHVETDFHSFRMILKTD 735
            +FP+  T E +SL+ +KKLFA +IS I Y+R +FPE ++ ++HL+ + LKILRED KCPG+  +I W++GCFDAL++ YL+  V+  YT+ K+P+ V E Y FKF Y ++  ++  D+++ +        K+    E IKK+++ L+R L +      PLP  V +TM L YY+ +TP+DY+P GF+    +     E E +N ++G V T FHS ++ + T+
Sbjct:   20 VFPSQITNEHESLIMVKKLFATSISCITYLRGLFPESSYGERHLDDLSLKILREDKKCPGSLHIIKWIQGCFDALEKRYLRMAVLTLYTNPKEPEKVTEIYQFKFKYTKEGATMDFDSSNTS-------FKSGTNSEDIKKASVLLIRKLYMLMQNLGPLPNDVILTMTLHYYNAVTPNDYQPPGFKEGVSSHLLLFEGEPVNLQVGMVSTGFHSMKVKVTTE 235          
BLAST of HORMA domain-containing protein vs. UniProt/SwissProt
Match: sp|E2RSQ2|HORM1_CANLF (HORMA domain-containing protein 1 OS=Canis lupus familiaris OX=9615 GN=HORMAD1 PE=3 SV=1)

HSP 1 Score: 190.274 bits (482), Expect = 8.407e-54
Identity = 97/242 (40.08%), Postives = 146/242 (60.33%), Query Frame = 1
Query:   28 MPVALLTKEKTWSKMFPTIFTTEQQSLVFMKKLFAVAISNIVYIRSIFPEYAFFDKHLEGIKLKILREDSKCPGASKVINWVRGCFDALDRHYLKAVVIGFYTDIKDPDTVIESYSFKFTYGQDSVSVKLDNTSKTDSGLEAVIKNDDAPETIKKSTLSLLRTLILAGNTQDPLPEKVFVTMKLLYYDEITPDDYEPNGFRTCDYAGFRHETETINAKLGHVETDFHSFRMILKTDKVSFTN 753
            M  A L +    + +FP   +TEQQSLV +K+L AV++S I Y+R IFPE A+  ++L+ + +KILRED  CPG+++++ W+ GC+DAL + YL+ VV+  YT+ +DP T+ E Y FKF Y  +     +D  SK  S   ++   D      KK+++ L+R + +      PLP  V +TMKL YYDE+TP DY+P GF+  D  G   E E +   +G V T FH+F++ + T+K    N
Sbjct:    1 MATAQLQRTSMSALVFPNKISTEQQSLVLVKRLLAVSVSCITYLRGIFPECAYGTRYLDDLCVKILREDKNCPGSTQLVKWMLGCYDALQKKYLRMVVLAVYTNPEDPQTISECYQFKFKYASNGPV--MDFISKNQSSESSMSSAD-----TKKASILLIRKIYILMQNLGPLPNDVCLTMKLFYYDEVTPPDYQPPGFKDGDCEGVIFEGEPMYLNVGEVPTPFHTFKVKVTTEKERMEN 235          
BLAST of HORMA domain-containing protein vs. UniProt/SwissProt
Match: sp|E2IUK4|HORM1_PIG (HORMA domain-containing protein 1 OS=Sus scrofa OX=9823 GN=HORMAD1 PE=2 SV=1)

HSP 1 Score: 190.274 bits (482), Expect = 9.102e-54
Identity = 99/244 (40.57%), Postives = 147/244 (60.25%), Query Frame = 1
Query:   28 MPVALLTKEKTWSKMFPTIFTTEQQSLVFMKKLFAVAISNIVYIRSIFPEYAFFDKHLEGIKLKILREDSKCPGASKVINWVRGCFDALDRHYLKAVVIGFYTDIKDPDTVIESYSFKFTYGQDSVSVKLDNTSKTDSGLEAVIKNDDAPETIKKSTLSLLRTLILAGNTQDPLPEKVFVTMKLLYYDEITPDDYEPNGFRTCDYAGFRHETETINAKLGHVETDFHSFRMILKTDKVSFTNNY 759
            M  A L +    + +FP   +TEQQSLV +K+L AV++S I Y+R IFPE A+  ++L+ + +KILRED  CPG+++++ W+ GC+DAL + YL+ VV+  YT+ +DP T+ E Y FKF Y   S    +D  SK  S   ++   D      KK+++ L+R + +      PLP  V +TMKL YYDE+TP DY+P GF+  D  G   E E +   +G V T FH+F++ + T+K    N Y
Sbjct:    1 MATAQLQRTSMSALVFPNKISTEQQSLVLVKRLLAVSVSCITYLRGIFPECAYGTRYLDDLCVKILREDKNCPGSTQLVKWMLGCYDALQKKYLRMVVLAVYTNPEDPQTISECYQFKFKYT--SNGPIMDFISKNQSSESSMSSAD-----TKKASILLIRKIYILMQNLGPLPNDVCLTMKLFYYDEVTPPDYQPPGFKDGDCEGVIFEGEPMYLNVGEVPTPFHTFKVKVTTEKERMENIY 237          
BLAST of HORMA domain-containing protein vs. UniProt/SwissProt
Match: sp|Q86X24|HORM1_HUMAN (HORMA domain-containing protein 1 OS=Homo sapiens OX=9606 GN=HORMAD1 PE=1 SV=1)

HSP 1 Score: 189.504 bits (480), Expect = 1.483e-53
Identity = 95/242 (39.26%), Postives = 145/242 (59.92%), Query Frame = 1
Query:   28 MPVALLTKEKTWSKMFPTIFTTEQQSLVFMKKLFAVAISNIVYIRSIFPEYAFFDKHLEGIKLKILREDSKCPGASKVINWVRGCFDALDRHYLKAVVIGFYTDIKDPDTVIESYSFKFTYGQDSVSVKLDNTSKTDSGLEAVIKNDDAPETIKKSTLSLLRTLILAGNTQDPLPEKVFVTMKLLYYDEITPDDYEPNGFRTCDYAGFRHETETINAKLGHVETDFHSFRMILKTDKVSFTN 753
            M  A L +    + +FP   +TE QSLV +K+L AV++S I Y+R IFPE A+  ++L+ + +KILRED  CPG+++++ W+ GC+DAL + YL+ VV+  YT+ +DP T+ E Y FKF Y  +     +D  SK  S   +++  D      KK+++ L+R + +      PLP  V +TMKL YYDE+TP DY+P GF+  D  G   E E +   +G V T FH F++ + T++    N
Sbjct:    1 MATAQLQRTPMSALVFPNKISTEHQSLVLVKRLLAVSVSCITYLRGIFPECAYGTRYLDDLCVKILREDKNCPGSTQLVKWMLGCYDALQKKYLRMVVLAVYTNPEDPQTISECYQFKFKYTNNGPL--MDFISKNQSNESSMLSTD-----TKKASILLIRKIYILMQNLGPLPNDVCLTMKLFYYDEVTPPDYQPPGFKDGDCEGVIFEGEPMYLNVGEVSTPFHIFKVKVTTERERMEN 235          
BLAST of HORMA domain-containing protein vs. TrEMBL
Match: A0A5K4EXM2 (Uncharacterized protein OS=Schistosoma mansoni OX=6183 PE=4 SV=1)

HSP 1 Score: 346.28 bits (887), Expect = 7.694e-110
Identity = 204/529 (38.56%), Postives = 294/529 (55.58%), Query Frame = 1
Query:   28 MPVALLTKEK--TWSKMFPTIFTTEQQSLVFMKKLFAVAISNIVYIRSIFPEYAFFDKHLEGIKLKILREDSKCPGASKVINWVRGCFDALDRHYLKAVVIGFYTDIKD--PD-----TVIESYSFKFTYGQDSVSVKLDNTSKTDSGLEAVIKNDDAPETIKKSTLSLLRTLILAGNTQDPLPEKVFVTMKLLYYDEITPDDYEPNGFRTCDYAGFRHETETINAKLGHVETDFHSFRMILKTDKVSFTNNYVKSSKSSNCNKPEFE---------KENETPVLNETRKITPNCSRTCSEEEFFVRCPCGGNKDDGIMIMCENCKNWQHSICFGIIEEDRVPEVHVCDICADANPNLKATDIKLKEFNEDRQVILFHNLFIKPLKEICLIRRALIYCKSSDVIEPGQLADVLGVEINVGKGVFHTLLKEGAL--VNPKRKTKNKGLSKVVDKVALESLVLNKYF-NSVVENNSPAKRKRKIDEVNLSKFTDNMSINENNLNFAIASQDSLIVEKCNKRRKGGIATTPV 1551
            M  A+  K+    WSKMFP     E QSLVF+KKLFAVA+S ++Y R IFPE AF DK LEGI+LKIL+E S  P +SK++ W++GCFDA+DRH+LK+  I  Y+  KD  P       +IESY F+ +YGQ+ +S+ L   +K +S     I +    E  +K+TLSLL+ +  AG     LP ++ +TMKL YYDE+TP+ Y P GF+  D   F  E + IN +LG+V+T  HS +M ++T +   + + VKS+KS+  ++   E         K NE   L+ + +     S     E +  RCPCG NKDDG+MI+C+ C  WQH++CF I++E  VP  HVC+ICA   P L  T     E           NL ++  K  CL RR L  C + D + P  +A  LG+E  V +G+F+ L+KE  +    P+R        K+V+K  LE++V  ++F ++ + + +  KR       + SK T     +E        SQD       +KRRK  +A TP+
Sbjct:    1 MATAVAVKQNIGNWSKMFPNELGVEIQSLVFIKKLFAVAVSYVLYFRDIFPESAFHDKQLEGIELKILKESSMLPASSKIVYWLKGCFDAIDRHFLKSATIALYSADKDLHPSEFCEYNIIESYCFRLSYGQEKLSLDLKTENKRESSTLCEISDFSEIEA-RKATLSLLKNIQTAGERLSKLPSELMITMKLQYYDEVTPESYVPPGFKRADNVSFNFEEDNINIRLGNVKTAHHSIKMHIQTSRRLLSGS-VKSTKSTQEDESIHELSLGSLNASKVNENDDLSLSFQQQTLVSDENESESYEARCPCGVNKDDGVMILCDGCDKWQHAVCFRILQEGDVPTSHVCEICAKLKPELLRTGGTTDE--------TIQNLSVEARKATCLFRRVLALCLNEDSVSPAFIARSLGIEYTVARGLFNRLIKEQVIKGAGPRRG------EKLVEKEYLENIVCPRFFSHNSLHDKTSMKRAH-----DASKSTSEKEYDE----LFNPSQDYRASPTTSKRRKMDMANTPI 504          
BLAST of HORMA domain-containing protein vs. TrEMBL
Match: A0A3Q0KSN1 (HORMA domain-containing protein OS=Schistosoma mansoni OX=6183 PE=4 SV=1)

HSP 1 Score: 342.428 bits (877), Expect = 5.144e-108
Identity = 208/548 (37.96%), Postives = 295/548 (53.83%), Query Frame = 1
Query:   28 MPVALLTKEK--TWSKMFPTIFTTEQQSLVFMKKLFAVAISNIVYIRSIFPEYAFFDKHLEGIKLKILREDSKCPGASKVINWVRGCFDALDRHYLKAVVIGFYTDIKD--PD-----TVIESYSFKFTYGQDSVSVKLDNTSKTDSGLEAVIKNDDAPETIKKSTLSLLRTLILAGNTQDPLPEKVFVTMKLLYYDEITPDDYEPNGFRTCDYAGFRHETETINAKLGHVETDFHSFRMILKTDKVSFTNNYVKSSKSSNCNKPEFE---------KENETPVLNETRKITPNCSRTCSEEEFFVRCPCGGNKDDGIMIMCENCKNWQHSICFGIIEEDRVPEVHVCDICADANPNLKATDIKLKEFNEDRQVILFHNLFIKPLKEICLIRRALIYCKSSDVIEPGQLADVLGVEINVGKGVFHTLLKEGAL--VNPKRKTKNKGLSKVVDKVALESLVLNKYF--NSVVENNS------------------PAKRKRKIDEVNLSKFTDNMSINENNLNFAIASQDSLIVEKCNKRRKGGIATTPV 1551
            M  A+  K+    WSKMFP     E QSLVF+KKLFAVA+S ++Y R IFPE AF DK LEGI+LKIL+E S  P +SK++ W++GCFDA+DRH+LK+  I  Y+  KD  P       +IESY F+ +YGQ+ +S+ L   +K +S     I +    E  +K+TLSLL+ +  AG     LP ++ +TMKL YYDE+TP+ Y P GF+  D   F  E + IN +LG+V+T  HS +M ++T +   + + VKS+KS+  ++   E         K NE   L+ + +     S     E +  RCPCG NKDDG+MI+C+ C  WQH++CF I++E  VP  HVC+ICA   P L  T     E           NL ++  K  CL RR L  C + D + P  +A  LG+E  V +G+F+ L+KE  +    P+R        K+V+K  LE++V  ++F  NS+ +  S                  P KR       + SK T     +E        SQD       +KRRK  +A TP+
Sbjct:    1 MATAVAVKQNIGNWSKMFPNELGVEIQSLVFIKKLFAVAVSYVLYFRDIFPESAFHDKQLEGIELKILKESSMLPASSKIVYWLKGCFDAIDRHFLKSATIALYSADKDLHPSEFCEYNIIESYCFRLSYGQEKLSLDLKTENKRESSTLCEISDFSEIEA-RKATLSLLKNIQTAGERLSKLPSELMITMKLQYYDEVTPESYVPPGFKRADNVSFNFEEDNINIRLGNVKTAHHSIKMHIQTSRRLLSGS-VKSTKSTQEDESIHELSLGSLNASKVNENDDLSLSFQQQTLVSDENESESYEARCPCGVNKDDGVMILCDGCDKWQHAVCFRILQEGDVPTSHVCEICAKLKPELLRTGGTTDE--------TIQNLSVEARKATCLFRRVLALCLNEDSVSPAFIARSLGIEYTVARGLFNRLIKEQVIKGAGPRRG------EKLVEKEYLENIVCPRFFSHNSLHDKTSMVSPQMLTAQKPTTIRRTPGKRAH-----DASKSTSEKEYDE----LFNPSQDYRASPTTSKRRKMDMANTPI 523          
BLAST of HORMA domain-containing protein vs. TrEMBL
Match: A0A504YP75 (HORMA domain-containing protein 2 OS=Fasciola gigantica OX=46835 GN=FGIG_01587 PE=4 SV=1)

HSP 1 Score: 331.643 bits (849), Expect = 1.284e-103
Identity = 203/568 (35.74%), Postives = 314/568 (55.28%), Query Frame = 1
Query:   28 MPVALLTKE--KTWSKMFPTIFTTEQQSLVFMKKLFAVAISNIVYIRSIFPEYAFFDKHLEGIKLKILREDSKCPGASKVINWVRGCFDALDRHYLKAVVIGFY----------TDIKDPDTVIESYSFKFTYGQDSVSVKLDNTSKTDSGLEAVIKNDDAPETIKKSTLSLLRTLILAGNTQDPLPEKVFVTMKLLYYDEITPDDYEPNGFRTCDYAGFRHETETINAKLGHVETDFHSFRMILKTDKVSFTN---------NYVKSSKSS-----------NCNKPEFEKENETPVLNETRKITPNCSRTCSEEEFFVRCPCGGNKDDGIMIMCENCKNWQHSICFGIIEEDRVPEVHVCDICADANPNL----KATDIKLKEFNEDRQVILFHNLFIKPLKEICLIRRALIYCKSSDVIEPGQLADVLGVEINVGKGVFHTLLKEGAL--VNPKRKTKNKGLSKVVDKVALESLVLNKYFNS-------VVEN---------------NSPAKRKRKIDEVNLSKFTDNMSINENNLNFAIASQDSLIVEKCNKRRKGGIATTPV 1551
            M  A+  KE   +WS++FPT   TE  SLVF+KKLFAVA+S ++Y+R +FPE AFFDK LEG++LKILRED K P +SKV+ W+RGCFDA+DR +LK+ +I  Y          TD +D   +IESYSFK TY   S+S+++ +T++  S     + N  + E IK++T++LL T+  A +    +PE +F+TM+L Y++E TP+DY P GFR  D   F  +   +N ++G+V+T FHS +M ++T+    +N         N ++ S+ S             +K   E E  + +  ++ +     S T   E + VRCPCG NKDDG+MI+C+ C  WQH++CF I+EE  VP  H+C++C  + PNL      TDI L+   ++ +            K  CL+RRA++ C S D + P  +A  L V+    +G+F+ L+KEGAL    PKR        K+V K  LE++V  + F +       V+E+               + P+   R+     L    ++   ++ +   + A +DS +  +  +R++ GIA TP+
Sbjct:    1 MATAVAAKEIVGSWSRLFPTELGTEVYSLVFVKKLFAVAVSYVLYLRRLFPENAFFDKQLEGVRLKILREDVKFPSSSKVVYWLRGCFDAIDRQFLKSAIITLYSQDQSDGISKTDYEDC-KIIESYSFKLTYANSSISLQVLSTNEESSSSTFKLSN-GSNEDIKRATINLLGTIRSACSKLRRIPENLFMTMRLQYFEETTPEDYIPPGFRAADDITFLFDGNPVNLRIGNVQTAFHSIKMNIQTNSEFLSNFKGISLNVDNNIELSQQSVDLDEEVAGVQTQSKSALEDELSSSLRQQSLQ-----SETDQSEMYDVRCPCGVNKDDGVMILCDGCGMWQHAVCFRILEEKDVPSSHICELCCVSKPNLLLDGGLTDITLQGITKENR------------KSQCLLRRAVLLCASLDSVSPSLIAKNLEVDYTTARGIFNRLVKEGALKDAGPKRG------EKLVQKEFLETVVFGRVFQTDSKQLGEVLESRDANQSPKNSNTPTTSHPSATMRRTPRRKLETPCESFLESQLDCRESQAPEDSPV--QVKRRKRSGIANTPI 541          
BLAST of HORMA domain-containing protein vs. TrEMBL
Match: A0A1S3IZ22 (LOW QUALITY PROTEIN: HORMA domain-containing protein 2-like OS=Lingula unguis OX=7574 GN=LOC106168814 PE=4 SV=1)

HSP 1 Score: 325.094 bits (832), Expect = 4.813e-102
Identity = 190/484 (39.26%), Postives = 263/484 (54.34%), Query Frame = 1
Query:   43 LTKEKTWSKMFPTIFTTEQQSLVFMKKLFAVAISNIVYIRSIFPEYAFFDKHLEGIKLKILREDSKCPGASKVINWVRGCFDALDRHYLKAVVIGFYTDIKDPDTVIESYSFKFTYGQDSVSVKLDNTSKTDSGLEAVIKNDD------APETIKKSTLSLLRTLILAGNTQDPLPEKVFVTMKLLYYDEITPDDYEPNGFRTCDYAGFRHETETINAKLGHVETDFHSFRMILKTDKVSFTNNYVKSSKSSN-------CNKPEFEKE-------------------------------------NETPVL--NETRKITPNCSRTC---SEEEFFVRCPCGGNKDDGIMIMCENCKNWQHSICFGIIEEDRVPEVHVCDICA-DANPNLKATDIKLKEFNEDRQVILFHNLFIKPLKEICLIRRALIYCKSSDVIEPGQLADVLGVEINVGKGVFHTLLKEGALVNPKRKTKNKGLSKVVDK 1326
            + K  +W   FPT   TE QS  F+KKL AVAISN+ Y+R+IFPE+AF DK LE + LKILRED+ CPGAS+VI W+RGCFDA D+ YLK ++IG Y D ++PDT+IESY+FKF Y              T++G   + +N D      +P   KK+T+ LLRT+++   T + LP+ V +TMKLLYYD++TP DYEP GF+  D   F  + E IN K+G V T FH+ ++ +KTD   F       + S N         K  +EKE                                      ETP     E R I+   S      ++EE  VRCPCG N+DDG+MI+C +C+ WQH++CFGII+E+  P+ H+C+ CA + +P  + TD +L   +E              ++   L RRAL+ C     I     A  LGVE+ V +G+ + L +E  L  P   +K K L K+V+K
Sbjct:   11 VQKTTSWL-AFPTEQATETQSATFVKKLLAVAISNVAYLRAIFPEHAFGDKCLEDLNLKILREDTACPGASQVIKWMRGCFDAFDKKYLKTLIIGIYVDPENPDTIIESYTFKFDY--------------TNNGGMDIYRNGDKLASAYSPSETKKATIKLLRTIVILTQTLNSLPDDVMMTMKLLYYDDVTPADYEPPGFQPVDTDYFMFDEEPINIKVGDVHTPFHALKLRIKTDGKQFEEQETVGADSQNIEDEAMMTEKSIYEKELYQADQKTIQNHTEASSSTLNTSSKLIKQPMQCEDVPVETPARPGTEDRAISTTGSARSNIDAQEENGVRCPCGCNEDDGLMILCASCRYWQHAVCFGIIDENEAPQNHICNFCANEEDPERQPTDPRLVGLDE------------IAVQATSLWRRALLTCSELSRIVLPNFARSLGVEMTVAQGLVNRLEREKFLKAP---SKGKRLGKIVEK 464          
BLAST of HORMA domain-containing protein vs. TrEMBL
Match: A0A4Z2CM86 (HORMA domain-containing protein OS=Schistosoma japonicum OX=6182 GN=EWB00_009285 PE=4 SV=1)

HSP 1 Score: 323.553 bits (828), Expect = 1.112e-100
Identity = 185/464 (39.87%), Postives = 270/464 (58.19%), Query Frame = 1
Query:   28 MPVALLTKEK--TWSKMFPTIFTTEQQSLVFMKKLFAVAISNIVYIRSIFPEYAFFDKHLEGIKLKILREDSKCPGASKVINWVRGCFDALDRHYLKAVVIGFYTDIKDPDT------VIESYSFKFTYGQDSVSVKLDNTSKTDSGLEAVIKNDDAPETIKKSTLSLLRTLILAGNTQDPLPEKVFVTMKLLYYDEITPDDYEPNGFRTCDYAGFRHETETINAKLGHVETDFHSFRMILKTDKVSFTNNYVKSSKSSNCNKPEFE---------KENETPVLNETRKITPNCSRTCSEEEFFVRCPCGGNKDDGIMIMCENCKNWQHSICFGIIEEDRVPEVHVCDICADANPN-LKATDIKLKEFNEDRQVILFHNLFIKPLKEICLIRRALIYCKSSDVIEPGQLADVLGVEINVGKGVFHTLLKEGALVNPKRKTKNKGLSKVVDKVALESLVLNKYFN 1365
            M  AL  K+    WSKMFP     E QSLVF+KKLFAVA+S ++Y R IFPE AF DK LEGI+LKIL+E S  P +SK++ W++GCFDA+DR +LK+  I  Y+  KD  +      V ESY F+ +Y +  +S+ L + +K +      I N    E I+K+TL+LL+ + +A      LP ++ +TMKL YYDE+TP++Y P GF+  D   F  E + IN +LG+V T  HS +M ++T +   + + VKS++S+  ++   E         K NE   L+ + +     S     + +  RCPCG NKDDG+MI+C+ C  WQH++CF I+EE  VP  HVC+ICA   P  L+A  I       D  +    NL ++  K  CL RRAL  C S D +    +A  LGVE  V +G+F+ L+KE  +   K +   +G  K+V+K  LE+++  ++F+
Sbjct:    1 MATALEIKQNIGNWSKMFPNELGVELQSLVFIKKLFAVAVSYVLYFRDIFPESAFHDKQLEGIELKILKESSILPASSKIVYWLKGCFDAIDRQFLKSATIALYSTKKDSHSNICEYNVFESYCFRLSYCRKKLSLDLTSENKREPSSVCEISNCSEAE-IRKATLNLLKNIQIASERLSKLPPELMITMKLQYYDEVTPENYVPPGFKRADDVTFTFEEDNINVRLGNVRTVHHSIKMHIQTSRRLLSGS-VKSTQSTQEDESIHELSLCSLGTSKANEKDDLSLSFQQQTLRSNENESQIYEARCPCGVNKDDGVMILCDGCDKWQHAVCFRILEEGDVPTSHVCEICAKLKPELLQAGGIT------DETI---QNLNVEARKATCLFRRALALCLSEDSVSSAFIARSLGVEYTVARGLFNRLIKEQVV---KGQGPRRG-EKLVEKEYLENIICPRFFS 449          
BLAST of HORMA domain-containing protein vs. Ensembl Cavefish
Match: hormad1 (HORMA domain containing 1 [Source:NCBI gene;Acc:103046361])

HSP 1 Score: 189.504 bits (480), Expect = 3.533e-55
Identity = 92/225 (40.89%), Postives = 140/225 (62.22%), Query Frame = 1
Query:   64 SKMFPTIFTTEQQSLVFMKKLFAVAISNIVYIRSIFPEYAFFDKHLEGIKLKILREDSKCPGASKVINWVRGCFDALDRHYLKAVVIGFYTDIKDPDTVIESYSFKFTYGQDSVSVKLDNTSKTDSGLEAVIKNDDAPETIKKSTLSLLRTLILAGNTQDPLPEKVFVTMKLLYYDEITPDDYEPNGFRTCDYAGFRHETETINAKLGHVETDFHSFRMILKTDK 738
            S+M P +  TEQQSLV +KKL A+A+S+I Y+R +FPE A+  K++E  K+ ILRE   CPGAS+++ W++GCFDAL + YL+ +++  Y+D + P  V E Y F+  Y +     +LD  SK    +  +  ND     IKK+++ L+R L        PLP+ V + MKL YYDE+TP+DY+P GF+  + +    E E +N  +G V T FH+ ++ + T+K
Sbjct:   14 SQMLPRVVATEQQSLVVVKKLLAIAVSSITYLRGLFPEKAYGSKYIEEQKVMILREQRTCPGASQIVQWLQGCFDALQKRYLRLILLSIYSDPEFPQKVTECYQFRIQYTEK--GPRLDFESKNQKRVTKMDCND-----IKKASILLVRKLYTLMQNLGPLPDSVCLNMKLSYYDEVTPEDYQPVGFKEGNNSTLVFEKEPVNLTMGEVVTPFHTLKVDVTTEK 231          
BLAST of HORMA domain-containing protein vs. Ensembl Cavefish
Match: hormad1 (HORMA domain containing 1 [Source:NCBI gene;Acc:103046361])

HSP 1 Score: 189.119 bits (479), Expect = 8.567e-55
Identity = 92/225 (40.89%), Postives = 140/225 (62.22%), Query Frame = 1
Query:   64 SKMFPTIFTTEQQSLVFMKKLFAVAISNIVYIRSIFPEYAFFDKHLEGIKLKILREDSKCPGASKVINWVRGCFDALDRHYLKAVVIGFYTDIKDPDTVIESYSFKFTYGQDSVSVKLDNTSKTDSGLEAVIKNDDAPETIKKSTLSLLRTLILAGNTQDPLPEKVFVTMKLLYYDEITPDDYEPNGFRTCDYAGFRHETETINAKLGHVETDFHSFRMILKTDK 738
            S+M P +  TEQQSLV +KKL A+A+S+I Y+R +FPE A+  K++E  K+ ILRE   CPGAS+++ W++GCFDAL + YL+ +++  Y+D + P  V E Y F+  Y +     +LD  SK    +  +  ND     IKK+++ L+R L        PLP+ V + MKL YYDE+TP+DY+P GF+  + +    E E +N  +G V T FH+ ++ + T+K
Sbjct:   14 SQMLPRVVATEQQSLVVVKKLLAIAVSSITYLRGLFPEKAYGSKYIEEQKVMILREQRTCPGASQIVQWLQGCFDALQKRYLRLILLSIYSDPEFPQKVTECYQFRIQYTEK--GPRLDFESKNQKRVTKMDCND-----IKKASILLVRKLYTLMQNLGPLPDSVCLNMKLSYYDEVTPEDYQPVGFKEGNNSTLVFEKEPVNLTMGEVVTPFHTLKVDVTTEK 231          
BLAST of HORMA domain-containing protein vs. Ensembl Cavefish
Match: hormad1 (HORMA domain containing 1 [Source:NCBI gene;Acc:103046361])

HSP 1 Score: 189.119 bits (479), Expect = 1.238e-54
Identity = 92/225 (40.89%), Postives = 140/225 (62.22%), Query Frame = 1
Query:   64 SKMFPTIFTTEQQSLVFMKKLFAVAISNIVYIRSIFPEYAFFDKHLEGIKLKILREDSKCPGASKVINWVRGCFDALDRHYLKAVVIGFYTDIKDPDTVIESYSFKFTYGQDSVSVKLDNTSKTDSGLEAVIKNDDAPETIKKSTLSLLRTLILAGNTQDPLPEKVFVTMKLLYYDEITPDDYEPNGFRTCDYAGFRHETETINAKLGHVETDFHSFRMILKTDK 738
            S+M P +  TEQQSLV +KKL A+A+S+I Y+R +FPE A+  K++E  K+ ILRE   CPGAS+++ W++GCFDAL + YL+ +++  Y+D + P  V E Y F+  Y +     +LD  SK    +  +  ND     IKK+++ L+R L        PLP+ V + MKL YYDE+TP+DY+P GF+  + +    E E +N  +G V T FH+ ++ + T+K
Sbjct:   14 SQMLPRVVATEQQSLVVVKKLLAIAVSSITYLRGLFPEKAYGSKYIEEQKVMILREQRTCPGASQIVQWLQGCFDALQKRYLRLILLSIYSDPEFPQKVTECYQFRIQYTEK--GPRLDFESKNQKRVTKMDCND-----IKKASILLVRKLYTLMQNLGPLPDSVCLNMKLSYYDEVTPEDYQPVGFKEGNNSTLVFEKEPVNLTMGEVVTPFHTLKVDVTTEK 231          
BLAST of HORMA domain-containing protein vs. Ensembl Cavefish
Match: zte38 (zebrafish testis-expressed 38 [Source:ZFIN;Acc:ZDB-GENE-060312-39])

HSP 1 Score: 174.866 bits (442), Expect = 4.957e-50
Identity = 85/222 (38.29%), Postives = 137/222 (61.71%), Query Frame = 1
Query:   61 WSKMFPTIFTTEQQSLVFMKKLFAVAISNIVYIRSIFPEYAFFDKHLEGIKLKILREDSKCPGASKVINWVRGCFDALDRHYLKAVVIGFYTDIKDPDTVIESYSFKFTYGQDSVSVKLDNTSKTDSGLEAVIKNDDAPETIKKSTLSLLRTLILAGNTQDPLPEKVFVTMKLLYYDEITPDDYEPNGFR--TCDYAGFRHETETINAKLGHVETDFHSFRM 720
            W  +F     T++QSLVF+K++  +A+S+I Y+R IFPE A+  ++LE + +K++RED   P A + + W+ GCFDAL++ YL+ V+IG + D  D + VIESY FKF Y +    + +      ++ +E  +  +D     KK+++ L+R L L     D LP++V++TMKL YYD++TP DYEP GF+   CD   F  E   ++ ++G + T FH  ++
Sbjct:   23 WDSLFQQELRTQEQSLVFVKRMLVLAVSSITYLRGIFPEDAYRSRYLEDLCIKVIREDCSSPAACRTVKWMMGCFDALEKEYLQIVLIGVHRDPDDTNHVIESYQFKFKYSEHGPQMDI----LRNNSMEMSVTMEDT----KKASVLLIRKLFLLMQNLDALPDEVYLTMKLYYYDDVTPPDYEPPGFKEGVCDSLWF--EGTAVHFRVGDLHTPFHVLKV 234          
BLAST of HORMA domain-containing protein vs. Ensembl Cavefish
Match: phf20l1 (PHD finger protein 20 like 1 [Source:NCBI gene;Acc:103026102])

HSP 1 Score: 62.7734 bits (151), Expect = 7.376e-10
Identity = 24/49 (48.98%), Postives = 34/49 (69.39%), Query Frame = 1
Query:  886 FVRCPCGGNKDDGIMIMCENCKNWQHSICFGIIEEDRVPEVHVCDICAD 1032
             VRC C  ++++G MI CE C  WQHS+C G++ ED +PE ++C IC D
Sbjct:  750 IVRCICEMDEENGFMIQCEECMCWQHSVCMGLL-EDSIPEQYICYICRD 797          
BLAST of HORMA domain-containing protein vs. Ensembl Sea Lamprey
Match: ENSPMAT00000009606.1 (pep scaffold:Pmarinus_7.0:GL481528:14094:14964:-1 gene:ENSPMAG00000008686.1 transcript:ENSPMAT00000009606.1 gene_biotype:protein_coding transcript_biotype:protein_coding)

HSP 1 Score: 75.485 bits (184), Expect = 4.784e-17
Identity = 34/92 (36.96%), Postives = 53/92 (57.61%), Query Frame = 1
Query:  478 ETIKKSTLSLLRTLILAGNTQDPLPEKVFVTMKLLYYDEITPDDYEPNGFRTCDYAGFRHETETINAKLGHVETDFHSFRMILKTDKVSFTN 753
            E  K++T+ L+R L +     D +PE V +TMKL YYDE+TP+DY+P GFR         + +    ++GHV + FHS ++ +  D+    N
Sbjct:   15 EETKRATILLIRKLFVLMQHLDEMPEDVSLTMKLFYYDEVTPEDYQPPGFRASSTDPLNFQGDPATLRVGHVASTFHSMKLRITVDRSQVDN 106          
BLAST of HORMA domain-containing protein vs. Ensembl Sea Lamprey
Match: ENSPMAT00000004065.1 (pep scaffold:Pmarinus_7.0:GL479372:18838:35317:1 gene:ENSPMAG00000003707.1 transcript:ENSPMAT00000004065.1 gene_biotype:protein_coding transcript_biotype:protein_coding)

HSP 1 Score: 62.7734 bits (151), Expect = 1.310e-10
Identity = 24/49 (48.98%), Postives = 32/49 (65.31%), Query Frame = 1
Query:  886 FVRCPCGGNKDDGIMIMCENCKNWQHSICFGIIEEDRVPEVHVCDICAD 1032
             VRC CG N++ G MI CE C  WQHS+C G  EE+ +P+ + C +C D
Sbjct:  646 IVRCSCGINEETGFMIQCEMCSCWQHSVCMGFTEEN-IPDRYSCHVCQD 693          
BLAST of HORMA domain-containing protein vs. Ensembl Sea Lamprey
Match: kmt2e (lysine (K)-specific methyltransferase 2E [Source:ZFIN;Acc:ZDB-GENE-030131-4120])

HSP 1 Score: 55.4546 bits (132), Expect = 1.981e-8
Identity = 21/46 (45.65%), Postives = 28/46 (60.87%), Query Frame = 1
Query:  889 VRCPCGGNKDDGIMIMCENCKNWQHSICFGIIEEDRVPEVHVCDIC 1026
             RC CG   DDG MI C+ C  WQH  C G I+  R+P+ ++C+ C
Sbjct:  117 TRCVCGFTHDDGYMICCDKCSVWQHIDCMG-IDRQRIPDTYLCEFC 161          
BLAST of HORMA domain-containing protein vs. Ensembl Yeast
Match: HOP1 (Meiosis-specific protein required for chromosome synapsis; displays Red1p dependent localization to the unsynapsed axial-lateral elements of the synaptonemal complex; required for chiasma formation; in vitro, displays the ability to promote intra- and intermolecular synapsis between double-stranded DNA molecules and to fold DNA into rigid protein-DNA filaments [Source:SGD;Acc:S000001334])

HSP 1 Score: 70.0922 bits (170), Expect = 3.944e-13
Identity = 77/351 (21.94%), Postives = 148/351 (42.17%), Query Frame = 1
Query:  100 QSLVFMKKLFAVAISNIVYIRSIFPEYAFFDKHL-----------------EGIKLKILREDSKCPGASKVINWV-RGCFDALDRHYLKAVVIGFYTDIKDPDTVIESYSFKFTYGQDSVSVKLDNTSKTDSGLEAVIKNDDAPETI-----KKSTLSLLRTLILAGNTQDPLPEKVFVTMKLLYYDEITPDDYEPNGFRTCDY---AGFRHETETINAKL--GHVETDFHSFRMILKTDKVSFTNNYVKSSKSSNCNKPEFE---KENETPVLNETRKITP----------------NCSRTCSEEEFFV---------RCPCGGN--KDDGIMIMCENCKNWQHSICFG 978
            QS   ++ +  ++   + ++R +FP+  F D+                     IK+K L    K   A  +++W+ +G F ++    LKA+ +G +  ++DP  ++E+Y F F Y +++      N S    G +     D   ETI     ++    L+R  I+   + +PLP+K F+TM+L++ D +  +DY+P  F+   +   A  +  T   N  +  G + T  H   + + +   + T++  K+  ++      F+   ++ E   L E+    P                N S+   +   FV          C CG    K   ++  C++C+   H IC+G
Sbjct:   21 QSQKLLQTMLTMSFGCLAFLRGLFPDDIFVDQRFVPEKVEKNYNKQNTSQNNSIKIKTLIR-GKSAQADLLLDWLEKGVFKSIRLKCLKALSLGIF--LEDPTDLLENYIFSFDYDEENNVNINVNLSGNKKGSKNA---DPENETISLLDSRRMVQQLMRRFIIITQSLEPLPQKKFLTMRLMFNDNVD-EDYQPELFKDATFDKRATLKVPTNLDNDAIDVGTLNTKHHKVALSVLS---AATSSMEKAGNTNFIRVDPFDLILQQQEENKLEESVPTKPQNFVTSQTTNVLGNLLNSSQASIQPTQFVSNNPVTGICSCECGLEVPKAATVLKTCKSCRKTLHGICYG 361          
BLAST of HORMA domain-containing protein vs. Ensembl Yeast
Match: SET3 (Defining member of the SET3 histone deacetylase complex; which is a meiosis-specific repressor of sporulation genes; necessary for efficient transcription by RNAPII; one of two yeast proteins that contains both SET and PHD domains; SET3 has a paralog, SET4, that arose from the whole genome duplication [Source:SGD;Acc:S000001737])

HSP 1 Score: 55.4546 bits (132), Expect = 1.611e-8
Identity = 19/47 (40.43%), Postives = 29/47 (61.70%), Query Frame = 1
Query:  886 FVRCPCGGNKDDGIMIMCENCKNWQHSICFGIIEEDRVPEVHVCDIC 1026
             + C C  N DDG  I C++C  WQH+IC+GI +    P+ ++C+ C
Sbjct:  117 IITCICDLNDDDGFTIQCDHCNRWQHAICYGIKDIGMAPDDYLCNSC 163          
BLAST of HORMA domain-containing protein vs. Ensembl Nematostella
Match: EDO47610 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7RLI6])

HSP 1 Score: 235.728 bits (600), Expect = 6.611e-71
Identity = 152/452 (33.63%), Postives = 225/452 (49.78%), Query Frame = 1
Query:   46 TKEKTWSKMFPTIFTTEQQSLVFMKKLFAVAISNIVYIRSIFPEYAFFDKHLEGIKLKILREDSKCPGASKVINWVRGCFDALDRHYLKAVVIGFYTDIKDPDTVIESYSFKFTYGQDSVSVKLDNTSKTDSGLEAVIKNDDAPETIKKSTLSLLRTLILAGNTQDPLPEKVFVTMKLLYYDEITPDDYEPNG-------FRTCDYAGFRHETETINAKLGHVETDFHSFRMI---LKTDKV---SFTNNYVKSSKSSNCNKPEFEKENETPVLNETRKITPNCSRTCSEEEFFVRCPCGGNKDDGIMIMCENCKNWQHSICFGIIEEDRVPEVHVCDICADANPNLKATDIKLKEFNEDRQVILFHNLFIKPLKEICLIRRALIYCKSSDVIEPGQLADVLGVEINVGKGVFHTLLKEGALVNPKRKTKNKGLSKVVDKVALESLVLNKYF 1362
            +K  +WS +FP    TEQQS++F+KKL AVA+S++ Y+R+IFPE+AF D+ LE + LKIL++DS CPGA +VI W++GCFDALD+ YL+ +VIG Y D  DPDT+IESY+FK  +        LD      S ++  IK +     +K+       T + AG     L        + +  D   P D+  N        F   D             K    ++D  S +++   ++ DKV   S     ++ S      +   +   ETP + E  + T +           V C CG N+DDG+MIMC  CK W+H++C+GI++E++ P+ HVC  C       + TD  L E                 L+   L RRAL+ C     I P  ++  LGVE+ V  G+ + L KEG +   +   K K L K+V+K  L+   L +Y 
Sbjct:   11 SKTVSWSSIFPPEQVTEQQSVLFVKKLLAVAVSSVSYLRAIFPEHAFGDRRLEDLNLKILKDDSACPGACQVIQWIKGCFDALDKKYLRMIVIGIYADADDPDTIIESYTFKNNH-------HLDTDPDITSRVKLRIKTELHQFELKEDDEEDDTTGVNAGG----LIRNNADVDEGMEEDSQMPLDHTDNTPVTHSREFEAVDDHTPPTTPTETTRKSAKRQSD--SQQVVPDGMECDKVPIESPNTPGLRGSAGGVSTRASSQPSGETPNIEEDMQKTDDT----------VSCACGYNEDDGLMIMCGICKFWEHAVCYGILQEEQAPDFHVCAKCCRKPGQPQCTDALLGELGS------------VELQAAALWRRALLACSEMSRILPTTMSRRLGVEMTVAHGLVNKLEKEGFV---RSAAKGKRLGKIVNKTMLKEEELKEYI 424          
BLAST of HORMA domain-containing protein vs. Ensembl Nematostella
Match: EDO37170 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7SGK9])

HSP 1 Score: 51.2174 bits (121), Expect = 8.992e-7
Identity = 27/78 (34.62%), Postives = 43/78 (55.13%), Query Frame = 1
Query:  889 VRCPCGGNKDDGIMIMCENCKNWQHSICFGIIEEDRVPEVHVCDICADANPNLKATDIKLK-EFNEDRQVILFHNLFI 1119
            +RC C  +++ G MI CE C  WQHS C G+ E   VP  ++C +C  +NP       K + +F+  ++ IL H  ++
Sbjct:  179 IRCRCNLSEEGGFMIQCEQCLTWQHSECVGLTEL-TVPSKYLCYVC--SNPKGLRRHAKYRNDFDWFKKGILAHFSYL 253          
BLAST of HORMA domain-containing protein vs. Ensembl Medaka
Match: hormad1 (HORMA domain-containing protein 1 [Source:NCBI gene;Acc:101155880])

HSP 1 Score: 168.318 bits (425), Expect = 4.900e-47
Identity = 85/237 (35.86%), Postives = 130/237 (54.85%), Query Frame = 1
Query:   28 MPVALLTKEKTWSKMFPTIFTTEQQSLVFMKKLFAVAISNIVYIRSIFPEYAFFDKHLEGIKLKILREDSKCPGASKVINWVRGCFDALDRHYLKAVVIGFYTDIKDPDTVIESYSFKFTYGQDSVSVKLDNTSKTDSGLEAVIKNDDAPETIKKSTLSLLRTLILAGNTQDPLPEKVFVTMKLLYYDEITPDDYEPNGFRTCDYAGFRHETETINAKLGHVETDFHSFRMILKTDK 738
            M  A   K    +++ P    TEQQS+V +KKL A+A+S I Y+R IFP  A+  K++E  ++ IL     CPGA ++I+W++GCFDA+ + +L+ V++  Y D ++P  V E Y F+  Y   S    +D  S ++  L      +      KK+++ L+R L        PLPE V + MKL YYD++TP DY+P GFR  +      E E +   +G V T FH  +  + T+K
Sbjct:    1 MAFAQRVKSSQVTQLLPNEVVTEQQSIVVVKKLLAIAVSAITYLRGIFPGKAYGTKYVEDQQVMILTGGRSCPGADQIIDWMQGCFDAIQKKFLRTVIMSIYNDPENPQKVTEYYQFRIQY--TSNGAHMDFESNSNQKLSTTTYGN-----TKKASILLVRKLYTLMQNLGPLPENVCLNMKLTYYDDVTPQDYQPPGFREAEGDVLEFEKEPVKLTMGEVTTPFHCVKFDMATEK 230          
BLAST of HORMA domain-containing protein vs. Ensembl Medaka
Match: zte38 (HORMA domain-containing protein 1-like [Source:NCBI gene;Acc:101175349])

HSP 1 Score: 165.236 bits (417), Expect = 7.737e-47
Identity = 77/205 (37.56%), Postives = 126/205 (61.46%), Query Frame = 1
Query:  124 LFAVAISNIVYIRSIFPEYAFFDKHLEGIKLKILREDSKCPGASKVINWVRGCFDALDRHYLKAVVIGFYTDIKDPDTVIESYSFKFTYGQDSVSVKLDNTSKTDSGLEAVIKNDDAPETIKKSTLSLLRTLILAGNTQDPLPEKVFVTMKLLYYDEITPDDYEPNGFRTCDYAGFRHETETINAKLGHVETDFHSFRMILKTDK 738
            + AVA+S+I Y+R IFPEYA+  ++L  + +K+L E+   PGASKV+ W+ G FDAL++ YL+ + IG YTD ++P+ +IE+Y F F Y +    + +      +  ++  ++N       K++++ L+R L L     D LP KV++TMKL YYD+ITP DY+P GF+   Y     E   ++ K+G V T +H+ R+ +  ++
Sbjct:    1 MMAVAVSSITYLRGIFPEYAYRSRYLADMCIKVLHENGNTPGASKVVKWLMGSFDALEKQYLQVISIGVYTDPENPNCIIEAYQFNFRYTEKGPEMNILRNKNVE--MQVTLEN------TKQASVLLIRKLFLLMQNLDALPNKVYLTMKLYYYDDITPADYQPPGFKEGVYDHLWFEGMPVHFKVGEVHTSYHALRVQVSVEQ 197          
BLAST of HORMA domain-containing protein vs. Ensembl Medaka
Match: hormad1 (HORMA domain-containing protein 1 [Source:NCBI gene;Acc:101155880])

HSP 1 Score: 153.295 bits (386), Expect = 1.474e-41
Identity = 82/237 (34.60%), Postives = 125/237 (52.74%), Query Frame = 1
Query:   28 MPVALLTKEKTWSKMFPTIFTTEQQSLVFMKKLFAVAISNIVYIRSIFPEYAFFDKHLEGIKLKILREDSKCPGASKVINWVRGCFDALDRHYLKAVVIGFYTDIKDPDTVIESYSFKFTYGQDSVSVKLDNTSKTDSGLEAVIKNDDAPETIKKSTLSLLRTLILAGNTQDPLPEKVFVTMKLLYYDEITPDDYEPNGFRTCDYAGFRHETETINAKLGHVETDFHSFRMILKTDK 738
            M  A   K    +++ P    TEQQS+V +KKL A+A+S I Y+R IFP  A+  K++E  ++ IL     CPGA ++I+W++GCFDA+ + +L+ V++           V E Y F+  Y   S    +D  S ++  L      +      KK+++ L+R L        PLPE V + MKL YYD++TP DY+P GFR  +      E E +   +G V T FH  +  + T+K
Sbjct:    1 MAFAQRVKSSQVTQLLPNEVVTEQQSIVVVKKLLAIAVSAITYLRGIFPGKAYGTKYVEDQQVMILTGGRSCPGADQIIDWMQGCFDAIQKKFLRTVIMS---------KVTEYYQFRIQY--TSNGAHMDFESNSNQKLSTTTYGN-----TKKASILLVRKLYTLMQNLGPLPENVCLNMKLTYYDDVTPQDYQPPGFREAEGDVLEFEKEPVKLTMGEVTTPFHCVKFDMATEK 221          
BLAST of HORMA domain-containing protein vs. Ensembl Medaka
Match: kmt2e (lysine methyltransferase 2E [Source:NCBI gene;Acc:101162568])

HSP 1 Score: 54.299 bits (129), Expect = 2.861e-7
Identity = 21/47 (44.68%), Postives = 28/47 (59.57%), Query Frame = 1
Query:  886 FVRCPCGGNKDDGIMIMCENCKNWQHSICFGIIEEDRVPEVHVCDIC 1026
              RC CG   DDG MI C+ C  WQH  C GI  ++ +PE ++C+ C
Sbjct:  116 ITRCICGFTHDDGYMICCDKCSAWQHIDCMGIDRQN-IPETYLCERC 161          
BLAST of HORMA domain-containing protein vs. Ensembl Medaka
Match: kmt2e (lysine methyltransferase 2E [Source:NCBI gene;Acc:101162568])

HSP 1 Score: 53.1434 bits (126), Expect = 4.902e-7
Identity = 21/46 (45.65%), Postives = 28/46 (60.87%), Query Frame = 1
Query:  889 VRCPCGGNKDDGIMIMCENCKNWQHSICFGIIEEDRVPEVHVCDIC 1026
             RC CG   DDG MI C+ C  WQH  C GI  ++ +PE ++C+ C
Sbjct:   53 TRCICGFTHDDGYMICCDKCSAWQHIDCMGIDRQN-IPETYLCERC 97          
BLAST of HORMA domain-containing protein vs. Planmine SMEST
Match: SMESG000066514.1 (SMESG000066514.1)

HSP 1 Score: 989.949 bits (2558), Expect = 0.000e+0
Identity = 489/513 (95.32%), Postives = 489/513 (95.32%), Query Frame = 1
Query:   28 MPVALLTKEKTWSKMFPTIFTTEQQSLVFMKKLFAVAISNIVYIRSIFPEYAFFDKHLEGIKLKILREDSKCPGASKVINWVRGCFDALDRHYLKAVVIGFYTDIKDPDTVIESYSFKFTYGQDSVSVKLDNTSKTDSGLEAVIKNDDAPETIKKSTLSLLRTLILAGNTQDPLPEKVFVTMKLLYYDEITPDDYEPNGFRTCDYAGFRHETETINAKLGHVETDFHSFRMILKTDKVSFTNNYVKSSKSSNCNKPEFEKENETPVLNETRKITPNCSRTCSEEEFFVRCPCGGNKDDGIMIMCENCKNWQHSICFGIIEEDRVPEVHVCDICADANPNLKATDIKLKEFNEDRQVILFHNLFIKPLKEICLIRRALIYCKSSDVIEPGQLADVLGVEINVGKGVFHTLLKEGALVNPKRKTKNKGLSKVVDKVALESLVLNKYFNSVVENNSPAKRKRKIDEVNLSKFTDNMSINENNLNFAIASQDSLIVEKCNKRRKGGIATTPVISSNH 1566
            MPVALLTKEKTWSKMFPTIFTTEQQSLVFMKKLFAVAISNIVYIRSIFPEYAFFDKHLEGIKLKILREDSKCPGASKVINWVRGCFDALDRHYLKAVVIGFYTDIKDPDTVIESYSFKFTYGQDSVSVKLDNTSKTDSGLEAVIKNDDAPETIKKSTLSLLRTLILAGNTQDPLPEKVFVTMKLLYYDEITPDDYEPNGFRTCDYAGFRHETETINAKLGHVETDFHSFRMILKTDKVSFTNNYVKSSKSSNCNKPEFEKENETPVLNETRKITPNCSRTCSEEEFFVRCPCGGNKDDGIMIMCENCKNWQHSICFGIIEEDRVPEVHVCDICADANPNLKATDIKLKEFNEDRQ             EICLIRRALIYCKSSDVIEPGQLADVLGVEINVGKGVFHTLLKEGALVNPKRKTKNKGLSKVVDKVALESLVLNKYFNSVVENNSPAKRKRKIDEVNLSKFTDNMSIN           DSLIVEKCNKRRKGGIATTPVISSNH
Sbjct:    1 MPVALLTKEKTWSKMFPTIFTTEQQSLVFMKKLFAVAISNIVYIRSIFPEYAFFDKHLEGIKLKILREDSKCPGASKVINWVRGCFDALDRHYLKAVVIGFYTDIKDPDTVIESYSFKFTYGQDSVSVKLDNTSKTDSGLEAVIKNDDAPETIKKSTLSLLRTLILAGNTQDPLPEKVFVTMKLLYYDEITPDDYEPNGFRTCDYAGFRHETETINAKLGHVETDFHSFRMILKTDKVSFTNNYVKSSKSSNCNKPEFEKENETPVLNETRKITPNCSRTCSEEEFFVRCPCGGNKDDGIMIMCENCKNWQHSICFGIIEEDRVPEVHVCDICADANPNLKATDIKLKEFNEDRQ-------------EICLIRRALIYCKSSDVIEPGQLADVLGVEINVGKGVFHTLLKEGALVNPKRKTKNKGLSKVVDKVALESLVLNKYFNSVVENNSPAKRKRKIDEVNLSKFTDNMSIN-----------DSLIVEKCNKRRKGGIATTPVISSNH 489          
The following BLAST results are available for this feature:
BLAST of HORMA domain-containing protein vs. Ensembl Human
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Human e!99)
Total hits: 5
Match NameE-valueIdentityDescription
HORMAD13.089e-5439.26HORMA domain containing 1 [Source:HGNC Symbol;Acc:... [more]
HORMAD26.781e-5336.26HORMA domain containing 2 [Source:HGNC Symbol;Acc:... [more]
HORMAD26.781e-5336.26HORMA domain containing 2 [Source:HGNC Symbol;Acc:... [more]
HORMAD12.446e-4938.02HORMA domain containing 1 [Source:HGNC Symbol;Acc:... [more]
HORMAD11.177e-3037.13HORMA domain containing 1 [Source:HGNC Symbol;Acc:... [more]
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BLAST of HORMA domain-containing protein vs. Ensembl Celegans
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99)
Total hits: 5
Match NameE-valueIdentityDescription
him-31.296e-1026.29High Incidence of Males (Increased X chromosome lo... [more]
him-31.296e-1026.29High Incidence of Males (Increased X chromosome lo... [more]
htp-16.825e-1024.68Him-Three Paralog [Source:UniProtKB/TrEMBL;Acc:Q2... [more]
htp-29.681e-923.58Him-Three Paralog [Source:UniProtKB/TrEMBL;Acc:Q9... [more]
set-97.407e-638.46Histone-lysine N-methyltransferase set-9 [Source:... [more]
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BLAST of HORMA domain-containing protein vs. Ensembl Fly
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99)
Total hits: 5
Match NameE-valueIdentityDescription
MBD-R22.402e-1028.79gene:FBgn0038016 transcript:FBtr0082611[more]
upSET1.221e-644.44gene:FBgn0036398 transcript:FBtr0333050[more]
upSET1.221e-644.44gene:FBgn0036398 transcript:FBtr0075768[more]
ash18.552e-631.91gene:FBgn0005386 transcript:FBtr0306009[more]
ash18.552e-631.91gene:FBgn0005386 transcript:FBtr0306010[more]
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BLAST of HORMA domain-containing protein vs. Ensembl Zebrafish
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99)
Total hits: 5
Match NameE-valueIdentityDescription
hormad14.804e-5441.96HORMA domain containing 1 [Source:NCBI gene;Acc:43... [more]
zte382.807e-4634.80zebrafish testis-expressed 38 [Source:ZFIN;Acc:ZDB... [more]
phf20l19.652e-1048.98PHD finger protein 20 like 1 [Source:ZFIN;Acc:ZDB-... [more]
phf20l11.227e-948.98PHD finger protein 20 like 1 [Source:ZFIN;Acc:ZDB-... [more]
phf20a1.224e-836.36PHD finger protein 20, a [Source:ZFIN;Acc:ZDB-GENE... [more]
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BLAST of HORMA domain-containing protein vs. Ensembl Xenopus
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99)
Total hits: 5
Match NameE-valueIdentityDescription
gstm18.356e-4538.57glutathione S-transferase mu 1 [Source:Xenbase;Acc... [more]
PHF20L13.925e-952.08PHD finger protein 20 like 1 [Source:NCBI gene;Acc... [more]
PHF20L15.003e-951.02PHD finger protein 20 like 1 [Source:NCBI gene;Acc... [more]
PHF202.026e-746.94PHD finger protein 20 [Source:NCBI gene;Acc:100126... [more]
KMT2E1.179e-643.48lysine (K)-specific methyltransferase 2E [Source:N... [more]
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BLAST of HORMA domain-containing protein vs. Ensembl Mouse
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99)
Total hits: 5
Match NameE-valueIdentityDescription
Hormad24.822e-5340.63HORMA domain containing 2 [Source:MGI Symbol;Acc:M... [more]
Hormad24.822e-5340.63HORMA domain containing 2 [Source:MGI Symbol;Acc:M... [more]
Hormad18.416e-5339.06HORMA domain containing 1 [Source:MGI Symbol;Acc:M... [more]
Hormad18.416e-5339.06HORMA domain containing 1 [Source:MGI Symbol;Acc:M... [more]
Hormad18.416e-5339.06HORMA domain containing 1 [Source:MGI Symbol;Acc:M... [more]
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BLAST of HORMA domain-containing protein vs. UniProt/SwissProt
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt)
Total hits: 5
Match NameE-valueIdentityDescription
sp|Q2KIY6|HORM1_BOVIN2.049e-5440.08HORMA domain-containing protein 1 OS=Bos taurus OX... [more]
sp|A6QQY4|HORM2_BOVIN2.136e-5439.91HORMA domain-containing protein 2 OS=Bos taurus OX... [more]
sp|E2RSQ2|HORM1_CANLF8.407e-5440.08HORMA domain-containing protein 1 OS=Canis lupus f... [more]
sp|E2IUK4|HORM1_PIG9.102e-5440.57HORMA domain-containing protein 1 OS=Sus scrofa OX... [more]
sp|Q86X24|HORM1_HUMAN1.483e-5339.26HORMA domain-containing protein 1 OS=Homo sapiens ... [more]
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BLAST of HORMA domain-containing protein vs. TrEMBL
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL)
Total hits: 5
Match NameE-valueIdentityDescription
A0A5K4EXM27.694e-11038.56Uncharacterized protein OS=Schistosoma mansoni OX=... [more]
A0A3Q0KSN15.144e-10837.96HORMA domain-containing protein OS=Schistosoma man... [more]
A0A504YP751.284e-10335.74HORMA domain-containing protein 2 OS=Fasciola giga... [more]
A0A1S3IZ224.813e-10239.26LOW QUALITY PROTEIN: HORMA domain-containing prote... [more]
A0A4Z2CM861.112e-10039.87HORMA domain-containing protein OS=Schistosoma jap... [more]
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BLAST of HORMA domain-containing protein vs. Ensembl Cavefish
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99)
Total hits: 5
Match NameE-valueIdentityDescription
hormad13.533e-5540.89HORMA domain containing 1 [Source:NCBI gene;Acc:10... [more]
hormad18.567e-5540.89HORMA domain containing 1 [Source:NCBI gene;Acc:10... [more]
hormad11.238e-5440.89HORMA domain containing 1 [Source:NCBI gene;Acc:10... [more]
zte384.957e-5038.29zebrafish testis-expressed 38 [Source:ZFIN;Acc:ZDB... [more]
phf20l17.376e-1048.98PHD finger protein 20 like 1 [Source:NCBI gene;Acc... [more]
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BLAST of HORMA domain-containing protein vs. Ensembl Sea Lamprey
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99)
Total hits: 3
Match NameE-valueIdentityDescription
ENSPMAT00000009606.14.784e-1736.96pep scaffold:Pmarinus_7.0:GL481528:14094:14964:-1 ... [more]
ENSPMAT00000004065.11.310e-1048.98pep scaffold:Pmarinus_7.0:GL479372:18838:35317:1 g... [more]
kmt2e1.981e-845.65lysine (K)-specific methyltransferase 2E [Source:Z... [more]
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BLAST of HORMA domain-containing protein vs. Ensembl Yeast
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46)
Total hits: 2
Match NameE-valueIdentityDescription
HOP13.944e-1321.94Meiosis-specific protein required for chromosome s... [more]
SET31.611e-840.43Defining member of the SET3 histone deacetylase co... [more]
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BLAST of HORMA domain-containing protein vs. Ensembl Nematostella
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46)
Total hits: 2
Match NameE-valueIdentityDescription
EDO476106.611e-7133.63Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7... [more]
EDO371708.992e-734.62Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7... [more]
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BLAST of HORMA domain-containing protein vs. Ensembl Medaka
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99)
Total hits: 5
Match NameE-valueIdentityDescription
hormad14.900e-4735.86HORMA domain-containing protein 1 [Source:NCBI gen... [more]
zte387.737e-4737.56HORMA domain-containing protein 1-like [Source:NCB... [more]
hormad11.474e-4134.60HORMA domain-containing protein 1 [Source:NCBI gen... [more]
kmt2e2.861e-744.68lysine methyltransferase 2E [Source:NCBI gene;Acc:... [more]
kmt2e4.902e-745.65lysine methyltransferase 2E [Source:NCBI gene;Acc:... [more]
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BLAST of HORMA domain-containing protein vs. Planmine SMEST
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST)
Total hits: 1
Match NameE-valueIdentityDescription
SMESG000066514.10.000e+095.32SMESG000066514.1[more]
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Sequences
The following sequences are available for this feature:

transcript sequence

>SMED30011381 ID=SMED30011381|Name=HORMA domain-containing protein|organism=Schmidtea mediterranea sexual|type=transcript|length=1619bp
GAAATTTTTCAAATAATCTGAAACAAAATGCCTGTTGCTCTACTAACAAA
AGAAAAGACATGGTCCAAAATGTTTCCTACTATATTTACAACAGAACAGC
AAAGTTTAGTATTTATGAAAAAATTGTTTGCAGTTGCCATTTCTAATATA
GTGTACATCAGATCGATTTTTCCTGAATATGCTTTTTTTGATAAGCATTT
GGAGGGTATAAAGCTAAAAATTCTTAGGGAAGATAGCAAATGTCCTGGAG
CGTCTAAAGTGATAAATTGGGTTAGAGGCTGTTTTGATGCTTTAGATCGA
CATTATTTGAAAGCAGTTGTGATTGGATTTTATACAGACATTAAAGATCC
AGATACAGTAATCGAATCGTATTCATTTAAATTCACTTATGGTCAAGATT
CTGTATCTGTAAAACTTGATAATACTTCCAAGACCGATTCCGGATTAGAA
GCTGTCATTAAAAATGATGATGCGCCAGAGACAATAAAAAAATCTACCTT
AAGTTTGCTCCGAACTTTGATTTTAGCTGGAAATACTCAGGACCCTTTGC
CAGAAAAGGTTTTTGTTACAATGAAATTGCTTTATTATGACGAAATTACT
CCTGACGATTATGAGCCCAATGGGTTTCGAACGTGTGACTATGCCGGTTT
TAGACACGAAACTGAAACTATTAATGCTAAATTAGGTCATGTTGAAACTG
ATTTTCACAGTTTCCGAATGATATTAAAAACGGATAAAGTATCATTTACT
AATAATTACGTAAAAAGTTCTAAAAGTAGTAACTGCAATAAGCCTGAATT
TGAAAAAGAAAATGAAACGCCTGTTTTAAATGAAACAAGAAAAATCACGC
CAAACTGTAGCAGGACTTGCTCTGAAGAGGAGTTTTTTGTCAGATGTCCT
TGTGGGGGAAACAAGGATGATGGAATTATGATAATGTGTGAAAATTGTAA
AAATTGGCAACACTCTATCTGTTTTGGAATTATAGAGGAAGATCGTGTTC
CTGAAGTTCATGTGTGTGATATATGCGCAGACGCCAACCCGAATTTGAAA
GCCACGGATATTAAATTGAAAGAGTTCAATGAAGACCGACAAGTAATTTT
ATTTCATAACTTATTTATCAAACCACTCAAGGAGATTTGCTTAATACGCA
GAGCGTTGATTTATTGCAAGTCATCTGATGTTATCGAACCTGGACAATTA
GCTGATGTATTAGGTGTTGAAATAAATGTTGGTAAAGGAGTTTTTCACAC
ATTGCTTAAAGAAGGAGCTTTAGTTAATCCTAAAAGAAAAACAAAAAATA
AAGGACTTTCAAAAGTTGTTGACAAAGTTGCTTTAGAATCCCTTGTATTA
AATAAATATTTTAATTCTGTCGTTGAAAATAATTCACCAGCAAAAAGAAA
GCGAAAAATTGATGAAGTAAACTTATCAAAATTTACGGATAATATGTCCA
TTAATGAAAACAACCTTAATTTTGCTATTGCATCCCAGGATTCATTAATC
GTTGAAAAATGCAATAAAAGAAGAAAAGGGGGGATTGCTACAACACCTGT
TATATCTTCGAATCATTAATGTGTTGTGTTTAGTTTTTAATAGTTATTAA
AATAAATTCTTTAAAATTA
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protein sequence of SMED30011381-orf-1

>SMED30011381-orf-1 ID=SMED30011381-orf-1|Name=SMED30011381-orf-1|organism=Schmidtea mediterranea sexual|type=polypeptide|length=514bp
MPVALLTKEKTWSKMFPTIFTTEQQSLVFMKKLFAVAISNIVYIRSIFPE
YAFFDKHLEGIKLKILREDSKCPGASKVINWVRGCFDALDRHYLKAVVIG
FYTDIKDPDTVIESYSFKFTYGQDSVSVKLDNTSKTDSGLEAVIKNDDAP
ETIKKSTLSLLRTLILAGNTQDPLPEKVFVTMKLLYYDEITPDDYEPNGF
RTCDYAGFRHETETINAKLGHVETDFHSFRMILKTDKVSFTNNYVKSSKS
SNCNKPEFEKENETPVLNETRKITPNCSRTCSEEEFFVRCPCGGNKDDGI
MIMCENCKNWQHSICFGIIEEDRVPEVHVCDICADANPNLKATDIKLKEF
NEDRQVILFHNLFIKPLKEICLIRRALIYCKSSDVIEPGQLADVLGVEIN
VGKGVFHTLLKEGALVNPKRKTKNKGLSKVVDKVALESLVLNKYFNSVVE
NNSPAKRKRKIDEVNLSKFTDNMSINENNLNFAIASQDSLIVEKCNKRRK
GGIATTPVISSNH*
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Annotated Terms
The following terms have been associated with this transcript:
Vocabulary: Planarian Anatomy
TermDefinition
PLANA:0000020protonephridia
PLANA:0000070intestinal phagocyte
PLANA:0000099neuron
PLANA:0000463cholinergic neuron
PLANA:0002075pigment cell
PLANA:0002109X1 cell
PLANA:0002111X2 cell
Vocabulary: INTERPRO
TermDefinition
IPR036570HORMA_dom_sf
IPR001965Znf_PHD
IPR013083Znf_RING/FYVE/PHD
IPR003511HORMA_dom
IPR011011Znf_FYVE_PHD
Vocabulary: molecular function
TermDefinition
GO:0008270zinc ion binding
GO:0005515protein binding
GO:0046872metal ion binding
InterPro
Analysis Name: Schmidtea mediteranean smed_20140614 Interproscan
Date Performed: 2020-05-01
IPR TermIPR DescriptionSourceSource TermSource DescriptionAlignment
IPR001965Zinc finger, PHD-typeSMARTSM00249PHD_3coord: 289..334
e-value: 9.4E-4
score: 28.5
IPR036570HORMA domain superfamilyGENE3DG3DSA:3.30.900.10coord: 10..279
e-value: 2.4E-74
score: 251.8
IPR036570HORMA domain superfamilySUPERFAMILYSSF56019The spindle assembly checkpoint protein mad2coord: 21..233
IPR013083Zinc finger, RING/FYVE/PHD-typeGENE3DG3DSA:3.30.40.10coord: 286..353
e-value: 1.5E-16
score: 61.6
IPR003511HORMA domainPFAMPF02301HORMAcoord: 26..227
e-value: 7.5E-55
score: 185.8
IPR003511HORMA domainPROSITEPS50815HORMAcoord: 24..233
score: 33.095
NoneNo IPR availablePANTHERPTHR46462FAMILY NOT NAMEDcoord: 253..335
NoneNo IPR availablePANTHERPTHR46462:SF3UPSET, ISOFORM Acoord: 253..335
IPR011011Zinc finger, FYVE/PHD-typeSUPERFAMILYSSF57903FYVE/PHD zinc fingercoord: 281..340