Leucine rich repeat containing 74A

Overview
NameLeucine rich repeat containing 74A
Smed IDSMED30011349
Length (bp)1170
Neoblast Clusters

Zeng et. al., 2018



▻ Overview

▻ Neoblast Population

▻ Sub-lethal Irradiated Surviving X1 and X2 Cell Population

 

 

Overview

 

Single cell RNA-seq of pluripotent neoblasts and its early progenies


We isolated X1 neoblasts cells enriched in high piwi-1 expression (Neoblast Population), and profiled ∼7,614 individual cells via scRNA-seq. Unsupervised analyses uncovered 12 distinct classes from 7,088 high-quality cells. We designated these classes Nb1 to Nb12 and ordered them based on high (Nb1) to low (Nb12) piwi-1 expression levels. We further defined groups of genes that best classified the cells parsed into 12 distinct cell clusters to generate a scaled expression heat map of discriminative gene sets for each cluster. Expression of each cluster’s gene signatures was validated using multiplex fluorescence in situ hybridization (FISH) co-stained with piwi-1 and largely confirmed the cell clusters revealed by scRNA-seq.

We also tested sub-lethal irradiation exposure. To profile rare pluripotent stem cells (PSCs) and avoid interference from immediate progenitor cells, we determined a time point after sub-lethal irradiation (7 DPI) with minimal piwi-1+ cells, followed by isolation and single-cell RNA-seq of 1,200 individual cells derived from X1 (Piwi-1 high) and X2 (Piwi-1 low) cell populations (Sub-lethal Irradiated Surviving X1 and X2 Cell Population)



Explore this single cell expression dataset with our NB Cluster Shiny App



 

Neoblast Population

 

t-SNE plot shows two-dimensional representation of global gene expression relationships among all neoblasts (n = 7,088 after filter). Cluster identity was assigned based on the top 10 marker genes of each cluster (Table S2), followed by inspection of RNA in situ hybridization patterns. Neoblast groups, Nb.


Expression of Leucine rich repeat containing 74A (SMED30011349) t-SNE clustered cells

Violin plots show distribution of expression levels for Leucine rich repeat containing 74A (SMED30011349) in cells (dots) of each of the 12 neoblast clusters.

 

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Sub-lethal Irradiated Surviving X1 and X2 Cell Population

 

t-SNE plot of surviving X1 and X2 cells (n = 1,039 after QC filter) after sub-lethal irradiation. Colors indicate unbiased cell classification via graph-based clustering. SL, sub-lethal irradiated cell groups.

Expression of Leucine rich repeat containing 74A (SMED30011349) in the t-SNE clustered sub-lethally irradiated X1 and X2 cells.

Violin plots show distribution of expression levels for Leucine rich repeat containing 74A (SMED30011349) in cells (dots) of each of the 10 clusters of sub-leathally irradiated X1 and X2 cells.

 

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Embryonic Expression

Davies et. al., 2017

Hover the mouse over a column in the graph to view average RPKM values per sample.
Sort Descending | Sort Ascending | Only Non-Zero Values | Tile/Chart | Reset

Embryonic Stages: Y: yolk. S2-S8: Stages 2-8. C4: asexual adult. SX: virgin, sexually mature adult.
For further information about sample preparation and analysis for the single animal RNA-Seq experiment, please refer to the Materials and Methods

 

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Anatomical Expression

PAGE et. al., 2020



SMED30011349

has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGE



PAGE Curations: 14

  
Expressed InReference TranscriptGene ModelsPublished TranscriptTranscriptomePublicationSpecimenLifecycleEvidence
head regionSMED30011349SMESG000008632.1 SmedASXL_012351SmedAsxl_ww_GCZZ01PMID:27034770
Currie et al., 2016		whole organism asexual adult RNA-sequencing evidence
head regionSMED30011349SMESG000008632.1 SmedASXL_012350SmedAsxl_ww_GCZZ01PMID:27034770
Currie et al., 2016		whole organism asexual adult RNA-sequencing evidence
nervous systemSMED30011349SMESG000008632.1 dd_Smed_v4_23416_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018		FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
cephalic gangliaSMED30011349SMESG000008632.1 dd_Smed_v4_23416_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018		FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
cilated neuronSMED30011349SMESG000008632.1 dd_Smed_v4_23416_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018		FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
nervous systemSMED30011349SMESG000008632.1 dd_Smed_v4_17064_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018		FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
cephalic gangliaSMED30011349SMESG000008632.1 dd_Smed_v4_17064_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018		FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
cilated neuronSMED30011349SMESG000008632.1 dd_Smed_v4_17064_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018		FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
Smed sexual biotypeSMED30011349SMESG000028489.1 SMESG000008632.1 Contig22031newmark_estsPMID:29674431
Fincher et al., 2018		FACS sorted cell population adult hermaphrodite single-cell RNA-sequencing evidence
Smed sexual biotypeSMED30011349SMESG000028489.1 SMESG000008632.1 Contig22031uc_Smed_v2PMID:29674431
Fincher et al., 2018		FACS sorted cell population adult hermaphrodite single-cell RNA-sequencing evidence
head regionSMED30011349SMESG000008632.1 dd_Smed_v6_17064_0_1dd_Smed_v6PMID:28171748
Stückemann et al., 2017		whole organism asexual adult RNA-sequencing evidence
head regionSMED30011349SMESG000008632.1 dd_Smed_v6_23416_0_1dd_Smed_v6PMID:28171748
Stückemann et al., 2017		whole organism asexual adult RNA-sequencing evidence
neuronSMED30011349SMESG000008632.1 dd_Smed_v6_23416_0_1dd_Smed_v6PMID:30399335
Ross et al., 2018		whole organism asexual adult colorimetric in situ hybridization evidence
GABAergic neuronSMED30011349SMESG000008632.1 dd_Smed_v6_17064_0dd_Smed_v6PMID:29674432
Plass et al., 2018		FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
Note: Hover over icons to view figure legend
Homology
[Close]
BLAST of Leucine rich repeat containing 74A vs. Ensembl Human
Match: LRRC74A (leucine rich repeat containing 74A [Source:HGNC Symbol;Acc:HGNC:23346])

HSP 1 Score: 77.411 bits (189), Expect = 8.669e-15
Identity = 56/204 (27.45%), Postives = 106/204 (51.96%), Query Frame = 2 
Query:   71 ISWNGLAEDGSLGFERCLSNNVILEELNVKSNRINFESLYRIGKGLRRNRTLKILKIGLNNLTLAG-ILDLMDAANSAESGLEYVDLEGQYVHSKVLYLIEKINRLRP-FHVAYEKVLDLEDEIYNAKPKDPMEFLLEYLSDRAIRVVDFFRMIDKDGMGEVSRSKFIRNM-KKNRVPLTSNEMQHVTSMIDENKSGMISYSKL 673
            +S NG   + +L     L  N  L  L++  N I  E   +I KGL  N +L++LK+ LN + + G IL ++    + +S +E +D+    V  + +  ++ +  + P   V ++ V  L  +       +PM+ +  Y     I +VDFF+ ++  G  ++S  +F + M ++N+VPL   +++ V   +DE K+GM+++S L
Sbjct:  281 LSMNGFGNEVALALGEVLRLNRCLVYLDIGGNDIGNEGASKISKGLESNESLRVLKLFLNPINMDGAILLILAIKRNPKSRMEELDISNVLVSEQFMKTLDGVYAVHPQLDVVFKAVQGLSPKKTIFLLTNPMKLIQSYADQHKITIVDFFKSLNPTGTMKMSVDEFQKVMIEQNKVPLNQYQVREVIKKLDE-KTGMVNFSFL 483
[Close]
BLAST of Leucine rich repeat containing 74A vs. Ensembl Human
Match: LRRC74B (leucine rich repeat containing 74B [Source:HGNC Symbol;Acc:HGNC:34301])

HSP 1 Score: 54.6842 bits (130), Expect = 9.863e-9
Identity = 36/115 (31.30%), Postives = 59/115 (51.30%), Query Frame = 2 
Query:   50 IILDFVYISWNGLAEDGSLGFERCLSNNVILEELNVKSNRINFESLYRIGKGLRRNRTLKILKIGLNNLTLAGILDLMDAA-NSAESGLEYVDLEGQYVHSKVLYLIEKINRLRP 391
            I L  + IS+NG  + G+      L  N +LEELN+ +NRI+      +G GLR N+TL+IL +  N +   G   L+ +  ++  S LE +D     V+++   L   +  + P
Sbjct:  247 IFLKVLDISYNGFGDPGASAVGEALKANNVLEELNMSNNRISAMGALSLGLGLRVNQTLRILVVSRNPMRSEGCFGLLKSVQDNPASALELLDFSDIQVNAEFDGLASSVRGILP 361

HSP 2 Score: 24.6386 bits (52), Expect = 9.863e-9
Identity = 9/19 (47.37%), Postives = 12/19 (63.16%), Query Frame = 1 
Query:    1 LKLLDISWNEIRGDAAYYF 57
            L  L++SWN +RG  A  F
Sbjct:  221 LTELNVSWNHLRGPGAVAF 239
[Close]
BLAST of Leucine rich repeat containing 74A vs. Ensembl Human
Match: DST (dystonin [Source:HGNC Symbol;Acc:HGNC:1090])

HSP 1 Score: 54.299 bits (129), Expect = 3.192e-7
Identity = 31/120 (25.83%), Postives = 58/120 (48.33%), Query Frame = 2 
Query:  473 LEYLSDRAIRVVDFFRMIDKDGMGEVSRSKFIRNMKKNRVPLTSNEMQHVTSMIDENKSGMISYSKLIQKLR----GYQKVVREKELSKRLTKDQKQEKIVIKAHIARLFEAGQFESPKF 820
            + +++ +  RV+DFFR IDKD  G+++R +FI  +  ++ P +  EM  V  + D +  G I Y + +  L      Y+ +    ++   +T+       V K   A+ F+  Q    K+
Sbjct: 7083 MRWMNHKKSRVMDFFRRIDKDQDGKITRQEFIDGILSSKFPTSRLEMSAVADIFDRDGDGYIDYYEFVAALHPNKDAYKPITDADKIEDEVTRQ------VAKCKCAKRFQVEQIGDNKY 7196
[Close]
BLAST of Leucine rich repeat containing 74A vs. Ensembl Human
Match: MACF1 (microtubule actin crosslinking factor 1 [Source:HGNC Symbol;Acc:HGNC:13664])

HSP 1 Score: 53.9138 bits (128), Expect = 3.197e-7
Identity = 29/111 (26.13%), Postives = 55/111 (49.55%), Query Frame = 2 
Query:  473 LEYLSDRAIRVVDFFRMIDKDGMGEVSRSKFIRNMKKNRVPLTSNEMQHVTSMIDENKSGMISYSKLIQKLR----GYQKVVREKELSKRLTKDQKQEKIVIKAHIARLFE 793
            + +++ +  RV+DFFR IDKD  G+++R +FI  +  ++ P T  EM  V  + D +  G I Y + +  L      Y+      ++   +T+   Q K   +  + ++ E
Sbjct:   60 MRWMNHKKSRVMDFFRRIDKDQDGKITRQEFIDGILASKFPTTKLEMTAVADIFDRDGDGYIDYYEFVAALHPNKDAYRPTTDADKIEDEVTRQVAQCKCAKRFQVEQIGE 170
[Close]
BLAST of Leucine rich repeat containing 74A vs. Ensembl Human
Match: DST (dystonin [Source:HGNC Symbol;Acc:HGNC:1090])

HSP 1 Score: 54.299 bits (129), Expect = 3.347e-7
Identity = 31/120 (25.83%), Postives = 58/120 (48.33%), Query Frame = 2 
Query:  473 LEYLSDRAIRVVDFFRMIDKDGMGEVSRSKFIRNMKKNRVPLTSNEMQHVTSMIDENKSGMISYSKLIQKLR----GYQKVVREKELSKRLTKDQKQEKIVIKAHIARLFEAGQFESPKF 820
            + +++ +  RV+DFFR IDKD  G+++R +FI  +  ++ P +  EM  V  + D +  G I Y + +  L      Y+ +    ++   +T+       V K   A+ F+  Q    K+
Sbjct: 2298 MRWMNHKKSRVMDFFRRIDKDQDGKITRQEFIDGILSSKFPTSRLEMSAVADIFDRDGDGYIDYYEFVAALHPNKDAYKPITDADKIEDEVTRQ------VAKCKCAKRFQVEQIGDNKY 2411
[Close]
BLAST of Leucine rich repeat containing 74A vs. Ensembl Fly
Match: shot (gene:FBgn0013733 transcript:FBtr0087621)

HSP 1 Score: 48.9062 bits (115), Expect = 7.736e-6
Identity = 23/73 (31.51%), Postives = 38/73 (52.05%), Query Frame = 2 
Query:  470 LLEYLSDRAIRVVDFFRMIDKDGMGEVSRSKFIRNMKKNRVPLTSNEMQHVTSMIDENKSGMISYSKLIQKLR 688
             L+Y++ +  R+ D FR +DKD  G + R  FI  +   +   +  EM+ V  + D N  G+I + + I  LR
Sbjct: 8365 FLKYMNHKKSRLTDLFRKMDKDNNGMIPRDVFIDGILNTKFDTSGLEMKAVADLFDRNGEGLIDWQEFIAALR 8437
[Close]
BLAST of Leucine rich repeat containing 74A vs. Ensembl Fly
Match: shot (gene:FBgn0013733 transcript:FBtr0087616)

HSP 1 Score: 48.9062 bits (115), Expect = 8.474e-6
Identity = 23/73 (31.51%), Postives = 38/73 (52.05%), Query Frame = 2 
Query:  470 LLEYLSDRAIRVVDFFRMIDKDGMGEVSRSKFIRNMKKNRVPLTSNEMQHVTSMIDENKSGMISYSKLIQKLR 688
             L+Y++ +  R+ D FR +DKD  G + R  FI  +   +   +  EM+ V  + D N  G+I + + I  LR
Sbjct: 4950 FLKYMNHKKSRLTDLFRKMDKDNNGMIPRDVFIDGILNTKFDTSGLEMKAVADLFDRNGEGLIDWQEFIAALR 5022
[Close]
BLAST of Leucine rich repeat containing 74A vs. Ensembl Fly
Match: shot (gene:FBgn0013733 transcript:FBtr0304850)

HSP 1 Score: 48.9062 bits (115), Expect = 8.475e-6
Identity = 23/73 (31.51%), Postives = 38/73 (52.05%), Query Frame = 2 
Query:  470 LLEYLSDRAIRVVDFFRMIDKDGMGEVSRSKFIRNMKKNRVPLTSNEMQHVTSMIDENKSGMISYSKLIQKLR 688
             L+Y++ +  R+ D FR +DKD  G + R  FI  +   +   +  EM+ V  + D N  G+I + + I  LR
Sbjct: 4990 FLKYMNHKKSRLTDLFRKMDKDNNGMIPRDVFIDGILNTKFDTSGLEMKAVADLFDRNGEGLIDWQEFIAALR 5062
[Close]
BLAST of Leucine rich repeat containing 74A vs. Ensembl Fly
Match: shot (gene:FBgn0013733 transcript:FBtr0273222)

HSP 1 Score: 48.9062 bits (115), Expect = 8.621e-6
Identity = 23/73 (31.51%), Postives = 38/73 (52.05%), Query Frame = 2 
Query:  470 LLEYLSDRAIRVVDFFRMIDKDGMGEVSRSKFIRNMKKNRVPLTSNEMQHVTSMIDENKSGMISYSKLIQKLR 688
             L+Y++ +  R+ D FR +DKD  G + R  FI  +   +   +  EM+ V  + D N  G+I + + I  LR
Sbjct: 4935 FLKYMNHKKSRLTDLFRKMDKDNNGMIPRDVFIDGILNTKFDTSGLEMKAVADLFDRNGEGLIDWQEFIAALR 5007
[Close]
BLAST of Leucine rich repeat containing 74A vs. Ensembl Fly
Match: shot (gene:FBgn0013733 transcript:FBtr0273225)

HSP 1 Score: 48.9062 bits (115), Expect = 8.854e-6
Identity = 23/73 (31.51%), Postives = 38/73 (52.05%), Query Frame = 2 
Query:  470 LLEYLSDRAIRVVDFFRMIDKDGMGEVSRSKFIRNMKKNRVPLTSNEMQHVTSMIDENKSGMISYSKLIQKLR 688
             L+Y++ +  R+ D FR +DKD  G + R  FI  +   +   +  EM+ V  + D N  G+I + + I  LR
Sbjct: 5046 FLKYMNHKKSRLTDLFRKMDKDNNGMIPRDVFIDGILNTKFDTSGLEMKAVADLFDRNGEGLIDWQEFIAALR 5118
[Close]
BLAST of Leucine rich repeat containing 74A vs. Ensembl Zebrafish
Match: lrrc74a (leucine rich repeat containing 74A [Source:ZFIN;Acc:ZDB-GENE-131127-263])

HSP 1 Score: 104.375 bits (259), Expect = 2.650e-24
Identity = 62/203 (30.54%), Postives = 111/203 (54.68%), Query Frame = 2 
Query:   71 ISWNGLAEDGSLGFERCLSNNVILEELNVKSNRINFESLYRIGKGLRRNRTLKILKIGLNNLTLAGILDLMDA-ANSAESGLEYVDLEGQYVHSKVLYLIEKINRLRP-FHVAYEKVLDLEDEIYNAKPK---DPMEFLLEYLSDRAIRVVDFFRMIDKDGMGEVSRSKFIRNMKKNRVPLTSNEMQHVTSMIDENKSGMISY 664
            +SWNG   +G+L     L  N  L+ L++ +NRI  E    + KGL  N TL++L++  N+LT+ G L L++   N+ +S +E +++    V+   + L++   + RP   V Y  V          KP+   DPM+ + +YL  R +R+ DFFR IDKDG   V    F + ++++ +PL   +++ +   +D +++G++ Y
Sbjct:  201 LSWNGFGNEGALALGEALKFNNTLQHLDLNNNRITDEGAGMLSKGLEANDTLRVLQLAYNSLTVEGALTLINTIKNTPKSAIEDINICNVLVNENFVQLLDLTCQERPSLEVQYGGV----GGFIAKKPRKRIDPMKIIQDYLDQRKLRLWDFFRNIDKDGTMRVPVVDFRKAVQQSSIPLERFQIEELIQRLDRDRTGVVDY 399
[Close]
BLAST of Leucine rich repeat containing 74A vs. Ensembl Zebrafish
Match: lrrc74b (leucine rich repeat containing 74B [Source:ZFIN;Acc:ZDB-GENE-141212-96])

HSP 1 Score: 67.781 bits (164), Expect = 1.039e-12
Identity = 38/94 (40.43%), Postives = 55/94 (58.51%), Query Frame = 2 
Query:   50 IILDFVYISWNGLAEDGSLGFERCLSNNVILEELNVKSNRINFESLYRIGKGLRRNRTLKILKIGLNNLTLAGILDLMDAANS-AESGLEYVDL 328
            I L  V +S+NGL +DG+L  E  L  N  LE+LN+ +NRI FE    +  GL+ N TL+ILK+  N +  AG   ++ +  S  ES  E++D 
Sbjct:  309 IFLRSVDLSYNGLGKDGALALEEALKQNNTLEDLNISNNRIPFEGAVHLALGLKVNTTLRILKMSRNPIQSAGCFAILKSVQSNPESAAEFLDF 402

HSP 2 Score: 24.6386 bits (52), Expect = 1.039e-12
Identity = 10/19 (52.63%), Postives = 13/19 (68.42%), Query Frame = 1 
Query:    1 LKLLDISWNEIRGDAAYYF 57
            LK L+++WN IRG  A  F
Sbjct:  283 LKALNLAWNCIRGKGAIAF 301
[Close]
BLAST of Leucine rich repeat containing 74A vs. Ensembl Zebrafish
Match: macf1a (microtubule actin crosslinking factor 1a [Source:ZFIN;Acc:ZDB-GENE-030131-3606])

HSP 1 Score: 52.373 bits (124), Expect = 9.793e-7
Identity = 29/116 (25.00%), Postives = 58/116 (50.00%), Query Frame = 2 
Query:  473 LEYLSDRAIRVVDFFRMIDKDGMGEVSRSKFIRNMKKNRVPLTSNEMQHVTSMIDENKSGMISYSKLIQKLRGYQKVVREKELSKRLTKDQKQEKIVIKAHIARLFEAGQFESPKF 820
            + +++ +  RV+DFFR IDKD  G+++R +FI  +  ++ P +  EM  V  + D +  G I Y + +  L   +   R    + ++  +  ++  V +   A+ F+  Q    K+
Sbjct: 5372 MRWMNHKKSRVMDFFRRIDKDQDGKITRQEFIDGILASKFPTSKLEMTAVADIFDRDCDGYIDYYEFVAALHPNKDAYRPTTDADKIEDEVTRQ--VAQCKCAKRFQVEQIGENKY 5485
[Close]
BLAST of Leucine rich repeat containing 74A vs. Ensembl Zebrafish
Match: macf1a (microtubule actin crosslinking factor 1a [Source:ZFIN;Acc:ZDB-GENE-030131-3606])

HSP 1 Score: 52.373 bits (124), Expect = 9.857e-7
Identity = 29/116 (25.00%), Postives = 58/116 (50.00%), Query Frame = 2 
Query:  473 LEYLSDRAIRVVDFFRMIDKDGMGEVSRSKFIRNMKKNRVPLTSNEMQHVTSMIDENKSGMISYSKLIQKLRGYQKVVREKELSKRLTKDQKQEKIVIKAHIARLFEAGQFESPKF 820
            + +++ +  RV+DFFR IDKD  G+++R +FI  +  ++ P +  EM  V  + D +  G I Y + +  L   +   R    + ++  +  ++  V +   A+ F+  Q    K+
Sbjct: 5004 MRWMNHKKSRVMDFFRRIDKDQDGKITRQEFIDGILASKFPTSKLEMTAVADIFDRDCDGYIDYYEFVAALHPNKDAYRPTTDADKIEDEVTRQ--VAQCKCAKRFQVEQIGENKY 5117
[Close]
BLAST of Leucine rich repeat containing 74A vs. Ensembl Zebrafish
Match: DST (dystonin [Source:HGNC Symbol;Acc:HGNC:1090])

HSP 1 Score: 51.9878 bits (123), Expect = 1.207e-6
Identity = 35/120 (29.17%), Postives = 58/120 (48.33%), Query Frame = 2 
Query:  473 LEYLSDRAIRVVDFFRMIDKDGMGEVSRSKFIRNMKKNRVPLTSNEMQHVTSMIDENKSGMISYSKLIQKLRGYQKVVREKELSKRLTKDQKQE----KIVIKAHIARLFEAGQFESPKF 820
            + +++ +  RV+DFFR IDKD  G+V+R +FI  +  ++ P +  EM  V  + D +  G I Y + +  L         K+  K LT   K E    + V K    + F+  Q  + K+
Sbjct: 3402 MRWMNHKKSRVMDFFRRIDKDQDGKVTRQEFIDGILSSKFPTSRLEMSAVADIFDRDGDGYIDYYEFVAALH------PNKDAYKPLTDADKIEDEVTRQVAKCKCPKRFQVEQIGANKY 3515
[Close]
BLAST of Leucine rich repeat containing 74A vs. Ensembl Xenopus
Match: ENSXETT00000010017.1 (pep primary_assembly:Xenopus_tropicalis_v9.1:1:141910231:141918723:1 gene:ENSXETG00000001685.1 transcript:ENSXETT00000010017.1 gene_biotype:protein_coding transcript_biotype:protein_coding)

HSP 1 Score: 58.9214 bits (141), Expect = 5.425e-9
Identity = 34/95 (35.79%), Postives = 53/95 (55.79%), Query Frame = 2 
Query:   50 IILDFVYISWNGLAEDGSLGFERCLSNNVILEELNVKSNRINFESLYRIGKGLRRNRTLKILKIGLNNLTLAGILDLMDA--ANSAESGLEYVDL 328
            I L  + +S+NG   DG+      L  N +LE++N+ +NRI+ +   R    L+ N+TL+ILKI  N +   G   ++ A  ANS ES +E +D 
Sbjct:  270 IFLKAIDLSYNGFGNDGAAALGEALKVNNVLEDINISNNRISVQGAVRFAMCLKANKTLRILKISRNPMQSEGCFAILKAIQANS-ESAMECLDF 363
[Close]
BLAST of Leucine rich repeat containing 74A vs. Ensembl Xenopus
Match: rab11fip2 (RAB11 family interacting protein 2 (class I) [Source:Xenbase;Acc:XB-GENE-5947669])

HSP 1 Score: 55.4546 bits (132), Expect = 1.424e-7
Identity = 31/120 (25.83%), Postives = 58/120 (48.33%), Query Frame = 2 
Query:  473 LEYLSDRAIRVVDFFRMIDKDGMGEVSRSKFIRNMKKNRVPLTSNEMQHVTSMIDENKSGMISYSKLIQKLR----GYQKVVREKELSKRLTKDQKQEKIVIKAHIARLFEAGQFESPKF 820
            + +++ +  RV+DFFR IDKD  G+++R +FI  +  ++ P +  EM  V  + D +  G I Y + +  L      Y+ +    ++   +T+       V K   A+ F+  Q    K+
Sbjct: 6200 MRWMNHKKSRVMDFFRRIDKDQDGKITRQEFIEGILSSKFPTSRLEMSAVADIFDRDGDGYIDYYEFVAALHPNKDAYKPITDADKIEDEVTRQ------VAKCKCAKRFQVEQIGENKY 6313
[Close]
BLAST of Leucine rich repeat containing 74A vs. Ensembl Xenopus
Match: rab11fip2 (RAB11 family interacting protein 2 (class I) [Source:Xenbase;Acc:XB-GENE-5947669])

HSP 1 Score: 55.4546 bits (132), Expect = 1.478e-7
Identity = 31/120 (25.83%), Postives = 58/120 (48.33%), Query Frame = 2 
Query:  473 LEYLSDRAIRVVDFFRMIDKDGMGEVSRSKFIRNMKKNRVPLTSNEMQHVTSMIDENKSGMISYSKLIQKLR----GYQKVVREKELSKRLTKDQKQEKIVIKAHIARLFEAGQFESPKF 820
            + +++ +  RV+DFFR IDKD  G+++R +FI  +  ++ P +  EM  V  + D +  G I Y + +  L      Y+ +    ++   +T+       V K   A+ F+  Q    K+
Sbjct: 6555 MRWMNHKKSRVMDFFRRIDKDQDGKITRQEFIEGILSSKFPTSRLEMSAVADIFDRDGDGYIDYYEFVAALHPNKDAYKPITDADKIEDEVTRQ------VAKCKCAKRFQVEQIGENKY 6668
[Close]
BLAST of Leucine rich repeat containing 74A vs. Ensembl Xenopus
Match: rab11fip2 (RAB11 family interacting protein 2 (class I) [Source:Xenbase;Acc:XB-GENE-5947669])

HSP 1 Score: 55.4546 bits (132), Expect = 1.584e-7
Identity = 31/120 (25.83%), Postives = 58/120 (48.33%), Query Frame = 2 
Query:  473 LEYLSDRAIRVVDFFRMIDKDGMGEVSRSKFIRNMKKNRVPLTSNEMQHVTSMIDENKSGMISYSKLIQKLR----GYQKVVREKELSKRLTKDQKQEKIVIKAHIARLFEAGQFESPKF 820
            + +++ +  RV+DFFR IDKD  G+++R +FI  +  ++ P +  EM  V  + D +  G I Y + +  L      Y+ +    ++   +T+       V K   A+ F+  Q    K+
Sbjct: 6559 MRWMNHKKSRVMDFFRRIDKDQDGKITRQEFIEGILSSKFPTSRLEMSAVADIFDRDGDGYIDYYEFVAALHPNKDAYKPITDADKIEDEVTRQ------VAKCKCAKRFQVEQIGENKY 6672
[Close]
BLAST of Leucine rich repeat containing 74A vs. Ensembl Xenopus
Match: rab11fip2 (RAB11 family interacting protein 2 (class I) [Source:Xenbase;Acc:XB-GENE-5947669])

HSP 1 Score: 55.0694 bits (131), Expect = 1.895e-7
Identity = 31/120 (25.83%), Postives = 58/120 (48.33%), Query Frame = 2 
Query:  473 LEYLSDRAIRVVDFFRMIDKDGMGEVSRSKFIRNMKKNRVPLTSNEMQHVTSMIDENKSGMISYSKLIQKLR----GYQKVVREKELSKRLTKDQKQEKIVIKAHIARLFEAGQFESPKF 820
            + +++ +  RV+DFFR IDKD  G+++R +FI  +  ++ P +  EM  V  + D +  G I Y + +  L      Y+ +    ++   +T+       V K   A+ F+  Q    K+
Sbjct: 5788 MRWMNHKKSRVMDFFRRIDKDQDGKITRQEFIEGILSSKFPTSRLEMSAVADIFDRDGDGYIDYYEFVAALHPNKDAYKPITDADKIEDEVTRQ------VAKCKCAKRFQVEQIGENKY 5901
[Close]
BLAST of Leucine rich repeat containing 74A vs. Ensembl Mouse
Match: Lrrc74a (leucine rich repeat containing 74A [Source:MGI Symbol;Acc:MGI:3646959])

HSP 1 Score: 73.559 bits (179), Expect = 9.102e-14
Identity = 54/204 (26.47%), Postives = 102/204 (50.00%), Query Frame = 2 
Query:   71 ISWNGLAEDGSLGFERCLSNNVILEELNVKSNRINFESLYRIGKGLRRNRTLKILKIGLNNLTLAGILDL-MDAANSAESGLEYVDLEGQYVHSKVLYLIEKINRLRP-FHVAYEKVLDLEDEIYNAKPKDPMEFLLEYLSDRAIRVVDFFRMIDKDGMGEVSRSKFIRNM-KKNRVPLTSNEMQHVTSMIDENKSGMISYSKL 673
            +S NG   +G+L     L  N  L  ++V  N I  E   +I KGL  N  L++LK+ LN L+L G   L M    + +S +E +D+    V  + + +++ +  + P   V Y+ +  L  +   +   +PM  +  Y   + I VV+FFR ++  G+  +    F + M +++ + +   +++ +   +DE K GM+++S L
Sbjct:  266 VSMNGFGNEGALALGDALRLNSCLVYVDVSRNGITNEGASKISKGLENNECLQVLKLFLNPLSLEGAYSLIMAIKRNPKSRMEDIDISNVLVSEQFVKVLDGVCAIHPQLDVVYKGLQGLSTKKSISLGTNPMRLIQSYTEQKKISVVEFFRSLNPTGLMTMPVGDFRKAMIQQSNILINRYQVRELIKKLDE-KKGMVNFSSL 468
[Close]
BLAST of Leucine rich repeat containing 74A vs. Ensembl Mouse
Match: Lrrc74a (leucine rich repeat containing 74A [Source:MGI Symbol;Acc:MGI:3646959])

HSP 1 Score: 72.7886 bits (177), Expect = 1.736e-13
Identity = 56/223 (25.11%), Postives = 109/223 (48.88%), Query Frame = 2 
Query:   71 ISWNGLAEDGSLGFERCLSNNVILEELNVKSNRINFESLYRIGKGLRRNRTLKILKIGLNNLTLAGILDL-MDAANSAESGLEYVDLEGQYVHSKVLYLIEKINRLRP-FHVAYEKVLDLEDEIYNAKPKDPMEFLLEYLSDRAIRVVDFFRMIDKDGMGEVSRSKFIRNM-KKNRVPLTSNEMQHVTSMIDENKSGMISYSKLIQKLRGYQKVVREKELSKR 730
            +S NG   +G+L     L  N  L  ++V  N I  E   +I KGL  N  L++LK+ LN L+L G   L M    + +S +E +D+    V  + + +++ +  + P   V Y+ +  L  +   +   +PM  +  Y   + I VV+FFR ++  G+  +    F + M +++ + +   +++ +   +DE K GM+++S  ++  +  Q V  E +   +
Sbjct:  266 VSMNGFGNEGALALGDALRLNSCLVYVDVSRNGITNEGASKISKGLENNECLQVLKLFLNPLSLEGAYSLIMAIKRNPKSRMEDIDISNVLVSEQFVKVLDGVCAIHPQLDVVYKGLQGLSTKKSISLGTNPMRLIQSYTEQKKISVVEFFRSLNPTGLMTMPVGDFRKAMIQQSNILINRYQVRELIKKLDE-KKGMVNFS-FLKAWKSQQPVRSESKCQSK 486
[Close]
BLAST of Leucine rich repeat containing 74A vs. Ensembl Mouse
Match: Dst (dystonin [Source:MGI Symbol;Acc:MGI:104627])

HSP 1 Score: 54.6842 bits (130), Expect = 4.649e-8
Identity = 31/120 (25.83%), Postives = 58/120 (48.33%), Query Frame = 2 
Query:  473 LEYLSDRAIRVVDFFRMIDKDGMGEVSRSKFIRNMKKNRVPLTSNEMQHVTSMIDENKSGMISYSKLIQKLR----GYQKVVREKELSKRLTKDQKQEKIVIKAHIARLFEAGQFESPKF 820
            + +++ +  RV+DFFR IDKD  G+++R +FI  +  ++ P +  EM  V  + D +  G I Y + +  L      Y+ +    ++   +T+       V K   A+ F+  Q    K+
Sbjct:   27 MRWMNHKKSRVMDFFRRIDKDQDGKITRQEFIDGILSSKFPTSRLEMSAVADIFDRDGDGYIDYYEFVAALHPNKDAYKPITDADKIEDEVTRQ------VAKCKCAKRFQVEQIGDNKY 140
[Close]
BLAST of Leucine rich repeat containing 74A vs. Ensembl Mouse
Match: Lrrc74b (leucine rich repeat containing 74B [Source:MGI Symbol;Acc:MGI:1921935])

HSP 1 Score: 54.299 bits (129), Expect = 1.276e-7
Identity = 37/115 (32.17%), Postives = 61/115 (53.04%), Query Frame = 2 
Query:   50 IILDFVYISWNGLAEDGSLGFERCLSNNVILEELNVKSNRINFESLYRIGKGLRRNRTLKILKIGLNNLTLAGILDLMDAA-NSAESGLEYVDLEGQYVHSKVLYLIEKINRLRP 391
            I L  + IS NG  + G+      L  N +LEELN+++NRI+     ++G GL+ N+TL+IL I  N +   G + L+ +  N+  S LE +D+    V  +   L   ++ + P
Sbjct:  245 IFLKVLDISHNGFGDSGASAIGDALRVNNVLEELNMRNNRISVSGALKLGLGLQVNQTLRILIISKNPIRSDGCVGLLKSVRNNKSSALELLDVSDIQVSRECEDLASSMSEILP 359
[Close]
BLAST of Leucine rich repeat containing 74A vs. Ensembl Mouse
Match: Dst (dystonin [Source:MGI Symbol;Acc:MGI:104627])

HSP 1 Score: 54.299 bits (129), Expect = 2.153e-7
Identity = 31/120 (25.83%), Postives = 58/120 (48.33%), Query Frame = 2 
Query:  473 LEYLSDRAIRVVDFFRMIDKDGMGEVSRSKFIRNMKKNRVPLTSNEMQHVTSMIDENKSGMISYSKLIQKLR----GYQKVVREKELSKRLTKDQKQEKIVIKAHIARLFEAGQFESPKF 820
            + +++ +  RV+DFFR IDKD  G+++R +FI  +  ++ P +  EM  V  + D +  G I Y + +  L      Y+ +    ++   +T+       V K   A+ F+  Q    K+
Sbjct: 7014 MRWMNHKKSRVMDFFRRIDKDQDGKITRQEFIDGILSSKFPTSRLEMSAVADIFDRDGDGYIDYYEFVAALHPNKDAYKPITDADKIEDEVTRQ------VAKCKCAKRFQVEQIGDNKY 7127
[Close]
BLAST of Leucine rich repeat containing 74A vs. UniProt/SwissProt
Match: sp|Q0VAA2|LR74A_HUMAN (Leucine-rich repeat-containing protein 74A OS=Homo sapiens OX=9606 GN=LRRC74A PE=2 SV=2)

HSP 1 Score: 77.411 bits (189), Expect = 4.163e-14
Identity = 56/204 (27.45%), Postives = 106/204 (51.96%), Query Frame = 2 
Query:   71 ISWNGLAEDGSLGFERCLSNNVILEELNVKSNRINFESLYRIGKGLRRNRTLKILKIGLNNLTLAG-ILDLMDAANSAESGLEYVDLEGQYVHSKVLYLIEKINRLRP-FHVAYEKVLDLEDEIYNAKPKDPMEFLLEYLSDRAIRVVDFFRMIDKDGMGEVSRSKFIRNM-KKNRVPLTSNEMQHVTSMIDENKSGMISYSKL 673
            +S NG   + +L     L  N  L  L++  N I  E   +I KGL  N +L++LK+ LN + + G IL ++    + +S +E +D+    V  + +  ++ +  + P   V ++ V  L  +       +PM+ +  Y     I +VDFF+ ++  G  ++S  +F + M ++N+VPL   +++ V   +DE K+GM+++S L
Sbjct:  281 LSMNGFGNEVALALGEVLRLNRCLVYLDIGGNDIGNEGASKISKGLESNESLRVLKLFLNPINMDGAILLILAIKRNPKSRMEELDISNVLVSEQFMKTLDGVYAVHPQLDVVFKAVQGLSPKKTIFLLTNPMKLIQSYADQHKITIVDFFKSLNPTGTMKMSVDEFQKVMIEQNKVPLNQYQVREVIKKLDE-KTGMVNFSFL 483
[Close]
BLAST of Leucine rich repeat containing 74A vs. UniProt/SwissProt
Match: sp|A0JPI9|LR74A_RAT (Leucine-rich repeat-containing protein 74A OS=Rattus norvegicus OX=10116 GN=Lrrc74a PE=2 SV=1)

HSP 1 Score: 71.2478 bits (173), Expect = 4.185e-12
Identity = 51/202 (25.25%), Postives = 102/202 (50.50%), Query Frame = 2 
Query:   71 ISWNGLAEDGSLGFERCLSNNVILEELNVKSNRINFESLYRIGKGLRRNRTLKILKIGLNNLTLAGILDLMDAAN-SAESGLEYVDLEGQYVHSKVLYLIEKINRLRP-FHVAYEKVLDLEDEIYNAKPKDPMEFLLEYLSDRAIRVVDFFRMIDKDGMGEVSRSKFIRN-MKKNRVPLTSNEMQHVTSMIDENKSGMISYS 667
            +S NG   DG+L     L  N  L  ++V  N I  E   RI KGL  N  L++LK+ LN ++L G   L+ A   + +S +E +D+    V  + + +++ +  + P   V Y+ +  L  +   +   +P++ +  Y     I VV+FF+ ++  G+  +    F +  +++  +P+   + + +   ++E K+GM+++S
Sbjct:  266 VSMNGFGNDGALALGDTLKLNSCLVYVDVSRNGITNEGASRISKGLENNECLQVLKLFLNPVSLEGAYSLILAIKRNPKSRMEDLDISNVLVSEQFVKVLDGVCAIHPQLDVVYKGLQGLSTKKTVSLETNPIKLIQNYTDQNKISVVEFFKSLNPSGLMTMPVGDFRKAIIQQTNIPINRYQARELIKKLEE-KNGMVNFS 466
[Close]
BLAST of Leucine rich repeat containing 74A vs. UniProt/SwissProt
Match: sp|Q6ZQY2|LR74B_HUMAN (Leucine-rich repeat-containing protein 74B OS=Homo sapiens OX=9606 GN=LRRC74B PE=2 SV=3)

HSP 1 Score: 54.6842 bits (130), Expect = 4.265e-8
Identity = 36/115 (31.30%), Postives = 59/115 (51.30%), Query Frame = 2 
Query:   50 IILDFVYISWNGLAEDGSLGFERCLSNNVILEELNVKSNRINFESLYRIGKGLRRNRTLKILKIGLNNLTLAGILDLMDAA-NSAESGLEYVDLEGQYVHSKVLYLIEKINRLRP 391
            I L  + IS+NG  + G+      L  N +LEELN+ +NRI+      +G GLR N+TL+IL +  N +   G   L+ +  ++  S LE +D     V+++   L   +  + P
Sbjct:  247 IFLKVLDISYNGFGDPGASAVGEALKANNVLEELNMSNNRISAMGALSLGLGLRVNQTLRILVVSRNPMRSEGCFGLLKSVQDNPASALELLDFSDIQVNAEFDGLASSVRGILP 361

HSP 2 Score: 24.6386 bits (52), Expect = 4.265e-8
Identity = 9/19 (47.37%), Postives = 12/19 (63.16%), Query Frame = 1 
Query:    1 LKLLDISWNEIRGDAAYYF 57
            L  L++SWN +RG  A  F
Sbjct:  221 LTELNVSWNHLRGPGAVAF 239
[Close]
BLAST of Leucine rich repeat containing 74A vs. UniProt/SwissProt
Match: sp|Q14BP6|LR74B_MOUSE (Leucine-rich repeat-containing protein 74B OS=Mus musculus OX=10090 GN=Lrrc74b PE=2 SV=1)

HSP 1 Score: 54.299 bits (129), Expect = 2.577e-7
Identity = 37/115 (32.17%), Postives = 61/115 (53.04%), Query Frame = 2 
Query:   50 IILDFVYISWNGLAEDGSLGFERCLSNNVILEELNVKSNRINFESLYRIGKGLRRNRTLKILKIGLNNLTLAGILDLMDAA-NSAESGLEYVDLEGQYVHSKVLYLIEKINRLRP 391
            I L  + IS NG  + G+      L  N +LEELN+++NRI+     ++G GL+ N+TL+IL I  N +   G + L+ +  N+  S LE +D+    V  +   L   ++ + P
Sbjct:  245 IFLKVLDISHNGFGDSGASAIGDALRVNNVLEELNMRNNRISVSGALKLGLGLQVNQTLRILIISKNPIRSDGCVGLLKSVRNNKSSALELLDVSDIQVSRECEDLASSMSEILP 359

HSP 2 Score: 22.3274 bits (46), Expect = 2.577e-7
Identity = 9/19 (47.37%), Postives = 12/19 (63.16%), Query Frame = 1 
Query:    1 LKLLDISWNEIRGDAAYYF 57
            L  L++SWN +RG  A  F
Sbjct:  219 LTELNLSWNHLRGLGATAF 237
[Close]
BLAST of Leucine rich repeat containing 74A vs. UniProt/SwissProt
Match: sp|Q91ZU6|DYST_MOUSE (Dystonin OS=Mus musculus OX=10090 GN=Dst PE=1 SV=2)

HSP 1 Score: 54.299 bits (129), Expect = 1.546e-6
Identity = 31/120 (25.83%), Postives = 58/120 (48.33%), Query Frame = 2 
Query:  473 LEYLSDRAIRVVDFFRMIDKDGMGEVSRSKFIRNMKKNRVPLTSNEMQHVTSMIDENKSGMISYSKLIQKLR----GYQKVVREKELSKRLTKDQKQEKIVIKAHIARLFEAGQFESPKF 820
            + +++ +  RV+DFFR IDKD  G+++R +FI  +  ++ P +  EM  V  + D +  G I Y + +  L      Y+ +    ++   +T+       V K   A+ F+  Q    K+
Sbjct: 7014 MRWMNHKKSRVMDFFRRIDKDQDGKITRQEFIDGILSSKFPTSRLEMSAVADIFDRDGDGYIDYYEFVAALHPNKDAYKPITDADKIEDEVTRQ------VAKCKCAKRFQVEQIGDNKY 7127
[Close]
BLAST of Leucine rich repeat containing 74A vs. TrEMBL
Match: A0A4V3SDS2 (Uncharacterized protein OS=Opisthorchis felineus OX=147828 GN=CRM22_007791 PE=4 SV=1)

HSP 1 Score: 152.525 bits (384), Expect = 4.129e-37
Identity = 79/221 (35.75%), Postives = 132/221 (59.73%), Query Frame = 2 
Query:   56 LDFVYISWNGLAEDGSLGFERCLSNNVILEELNVKSNRINFESLYRIGKGLRRNRTLKILKIGLNNLTLAGILDLMDA-ANSAESGLEYVDLEGQYVHSKVLYLIEKINRLRPFHVAYEKVLDLEDEIYNAKPKDPMEFLLEYLSDRAIRVVDFFRMIDKDGMGEVSRSKFIRNMKKNRVPLTSNEMQHVTSMIDENKSGMISYSKLIQKLRGYQKVVREK 715
            L  + +SWNG A  G+      L+ N  LEEL++KSNRI   ++  + KGL++N TLK+L++GLN LTL+G+  L+    ++A SGL  +DLEG  ++ K+  +  +I+  RPF +  E  +  E        +DPM FL+ YL+   IR+VDF+R+ID    G +SR++FI  + + ++PL +N++Q +   ID   +  I++     ++  Y+  VR++
Sbjct:  288 LHLLDLSWNGFALRGTEALCEGLTRNKSLEELDLKSNRIELRAVLPLTKGLQQNSTLKVLRLGLNPLTLSGVHQLLHVLEHTATSGLTVLDLEGIQLNEKLTLIAHRISNSRPFTLLNENCVSWETSGGKYAKQDPMTFLMNYLNKHGIRIVDFYRLIDLQQAGMLSRAEFIEGVLQQKIPLNANDLQTILDYIDHENTNQITHQLFFSRMYLYRITVRDQ 508
[Close]
BLAST of Leucine rich repeat containing 74A vs. TrEMBL
Match: A0A3R7HBG0 (Leucine-rich repeat-containing protein 74A OS=Clonorchis sinensis OX=79923 GN=Lrrc74a PE=4 SV=1)

HSP 1 Score: 150.599 bits (379), Expect = 1.959e-36
Identity = 78/221 (35.29%), Postives = 131/221 (59.28%), Query Frame = 2 
Query:   56 LDFVYISWNGLAEDGSLGFERCLSNNVILEELNVKSNRINFESLYRIGKGLRRNRTLKILKIGLNNLTLAGILDLMDA-ANSAESGLEYVDLEGQYVHSKVLYLIEKINRLRPFHVAYEKVLDLEDEIYNAKPKDPMEFLLEYLSDRAIRVVDFFRMIDKDGMGEVSRSKFIRNMKKNRVPLTSNEMQHVTSMIDENKSGMISYSKLIQKLRGYQKVVREK 715
            L  + +SWNG A  G+      L+ N  LEEL++KSNRI   ++  + KGL++N TLK+L++GLN LT++G+  L+    ++A SGL  +DLEG  ++ K+  +  +I+  RPF +  E  +  E        +DPM FL+ YL+   IR+VDF+R+ID    G +SR+ FI  + + ++PL +N++Q +   ID   +  I++     ++  Y+  VR++
Sbjct:  288 LRLLDLSWNGFALRGTEALCEGLTRNKSLEELDLKSNRIELRAVLPLTKGLQQNSTLKVLRLGLNPLTVSGVHQLLHTLEHTATSGLTVLDLEGIQLNEKLTQIAHRISNSRPFTLLNENCVSWETRGGKYAKQDPMTFLMNYLNKHGIRIVDFYRLIDLQQTGMLSRADFIEGVLQQKIPLNANDLQTILDYIDHENTNQITHQLFFSRMYLYRITVRDQ 508
[Close]
BLAST of Leucine rich repeat containing 74A vs. TrEMBL
Match: A0A075A9S4 (Uncharacterized protein (Fragment) OS=Opisthorchis viverrini OX=6198 GN=T265_14458 PE=4 SV=1)

HSP 1 Score: 145.976 bits (367), Expect = 3.271e-35
Identity = 77/221 (34.84%), Postives = 129/221 (58.37%), Query Frame = 2 
Query:   56 LDFVYISWNGLAEDGSLGFERCLSNNVILEELNVKSNRINFESLYRIGKGLRRNRTLKILKIGLNNLTLAGILDLMDA-ANSAESGLEYVDLEGQYVHSKVLYLIEKINRLRPFHVAYEKVLDLEDEIYNAKPKDPMEFLLEYLSDRAIRVVDFFRMIDKDGMGEVSRSKFIRNMKKNRVPLTSNEMQHVTSMIDENKSGMISYSKLIQKLRGYQKVVREK 715
            L  + +SWNG A  G+      L+ N  LEEL++KSNRI   ++  + K L++N TLK+L++GLN LT++G+  L+    ++A SGL  +DLEG  +  K+  +  +I+ LR F +  E  +  E        +DPM FL+ YL+   IR+VDF+R+ID    G +SR+ FI  + + ++PL +N++Q +   ID   +  I++     ++  Y+  VR++
Sbjct:  163 LHLLDLSWNGFALRGTEALCEGLTRNNSLEELDLKSNRIELRAVLPLTKALQQNSTLKVLRLGLNPLTVSGVHQLLHILEHTATSGLTVLDLEGMQLTEKLTQIAHRISNLRRFTLLNENCVSWETRGGKYAKQDPMTFLMNYLNKHGIRIVDFYRLIDLQQTGMLSRADFIEGILQQKIPLNANDLQTILDYIDPENTNQITHQLFFSRMYLYRITVRDQ 383
[Close]
BLAST of Leucine rich repeat containing 74A vs. TrEMBL
Match: A0A1S8X8V7 (Leucine Rich repeat-containing domain protein (Fragment) OS=Opisthorchis viverrini OX=6198 GN=X801_00972 PE=4 SV=1)

HSP 1 Score: 145.976 bits (367), Expect = 3.870e-35
Identity = 77/221 (34.84%), Postives = 129/221 (58.37%), Query Frame = 2 
Query:   56 LDFVYISWNGLAEDGSLGFERCLSNNVILEELNVKSNRINFESLYRIGKGLRRNRTLKILKIGLNNLTLAGILDLMDA-ANSAESGLEYVDLEGQYVHSKVLYLIEKINRLRPFHVAYEKVLDLEDEIYNAKPKDPMEFLLEYLSDRAIRVVDFFRMIDKDGMGEVSRSKFIRNMKKNRVPLTSNEMQHVTSMIDENKSGMISYSKLIQKLRGYQKVVREK 715
            L  + +SWNG A  G+      L+ N  LEEL++KSNRI   ++  + K L++N TLK+L++GLN LT++G+  L+    ++A SGL  +DLEG  +  K+  +  +I+ LR F +  E  +  E        +DPM FL+ YL+   IR+VDF+R+ID    G +SR+ FI  + + ++PL +N++Q +   ID   +  I++     ++  Y+  VR++
Sbjct:  181 LHLLDLSWNGFALRGTEALCEGLTRNNSLEELDLKSNRIELRAVLPLTKALQQNSTLKVLRLGLNPLTVSGVHQLLHILEHTATSGLTVLDLEGMQLTEKLTQIAHRISNLRRFTLLNENCVSWETRGGKYAKQDPMTFLMNYLNKHGIRIVDFYRLIDLQQTGMLSRADFIEGILQQKIPLNANDLQTILDYIDPENTNQITHQLFFSRMYLYRITVRDQ 401
[Close]
BLAST of Leucine rich repeat containing 74A vs. TrEMBL
Match: A0A2T7NX65 (Uncharacterized protein OS=Pomacea canaliculata OX=400727 GN=C0Q70_13420 PE=4 SV=1)

HSP 1 Score: 144.821 bits (364), Expect = 4.946e-34
Identity = 77/231 (33.33%), Postives = 137/231 (59.31%), Query Frame = 2 
Query:   71 ISWNGLAEDGSLGFERCLSNNVILEELNVKSNRINFESLYRIGKGLRRNRTLKILKIGLNNLTLAGILDLMDAANSAESGLEYVDLEGQYVHSKVLYLIEKINRLRPFHVAYEKVLDLED--EIYNAKPKDPMEFLLEYLSDRAIRVVDFFRMIDKDGMGEVSRSKFIRNMKKNRVPLTSNEMQHVTSMIDENKSGMISYSKLIQKLRGYQKVVREKELSKRLTKDQKQEK 757
            ++WNGLA +GSL     L +N  L++L++ +NR+N++ +  + + L  NRTL++L+IG N +++ G + L++A +   S + ++ L    + +K  +   +I + R F + +  V+   D   +   K +DP+  L+ YLS   IRVVD FR+ D D    VS + FIR +K+ RVPL S++M  V   +  NK+G ISY +L   +R + +  R ++L ++  +++K+EK
Sbjct:  500 LAWNGLAWEGSLSLSEALRSNRTLKKLDISNNRVNWDCIPYLARALSVNRTLEVLEIGHNPVSMDGCMKLLEALDRPSSRITFLSLAEIPIDAKTAFKAAEIAKRRKFTMEHGGVITTRDIFGVQRTKREDPVSLLIRYLSTMGIRVVDLFRVFDTDSRLCVSEANFIRGLKRVRVPLDSDDMMRVARRMQSNKNGEISYQELAASVRSHIREERREDLRQQRLENKKREK 730
[Close]
BLAST of Leucine rich repeat containing 74A vs. Ensembl Cavefish
Match: lrrc74a (leucine rich repeat containing 74A [Source:NCBI gene;Acc:103039030])

HSP 1 Score: 108.997 bits (271), Expect = 1.688e-25
Identity = 73/246 (29.67%), Postives = 133/246 (54.07%), Query Frame = 2 
Query:   50 IILDFVYISWNGLAEDGSLGFERCLSNNVILEELNVKSNRINFESLYRIGKGLRRNRTLKILKIGLNNLTLAGILDLMDAA-NSAESGLEYVDLEGQYVHSKVLYLIEKINRLRP-FHVAYEKVLDLEDEIYNAKPK--DPMEFLLEYLSDRAIRVVDFFRMIDKDGMGEVSRSKFIRNMKKNRVPLTSNEMQHVTSMIDENKSGMISYSKLI----QKLRGYQKVVREKELSKRLTKDQKQEKIV 763
            + L  + +SWNG   +G+L     L  N  L +L++ +NRI  E +  + +GL  N TL+ LK+  N+LT+ G L L+    N+ ++ +E +++    V+   + L+E   +  P   V Y  V      I    PK  DPM+ + +YL +R +R+ DFFR IDKDG   V  S+F + ++++ +PL   +++ +   +D   +G + Y  L     Q +R +++ +R+ E S++  + QK ++I+
Sbjct:  239 VTLKQLDLSWNGFGNEGALALGEALKFNNTLVDLDLSNNRITNEGVGMLCRGLEANDTLRTLKLAYNSLTVEGALALIRVVKNTPKTAIEEINICNVLVNENFVQLLELTCQEHPSLEVQYGGVGGF---IAKKPPKRADPMKVIQDYLDERKLRLWDFFRNIDKDGTMRVPVSEFRKAVQQSSIPLDRFQIEELIQRLDREGTGSVDYRGLADTRKQMMRDHRRQLRKVE-SRQKKEKQKSDRIL 480
[Close]
BLAST of Leucine rich repeat containing 74A vs. Ensembl Cavefish
Match: MACF1 (microtubule actin crosslinking factor 1 [Source:HGNC Symbol;Acc:HGNC:13664])

HSP 1 Score: 54.6842 bits (130), Expect = 1.456e-7
Identity = 36/149 (24.16%), Postives = 73/149 (48.99%), Query Frame = 2 
Query:  374 INRLRPFHVAYEKVLDLEDEIYNAKPKDPMEFLLEYLSDRAIRVVDFFRMIDKDGMGEVSRSKFIRNMKKNRVPLTSNEMQHVTSMIDENKSGMISYSKLIQKLRGYQKVVREKELSKRLTKDQKQEKIVIKAHIARLFEAGQFESPKF 820
            ++R R  H A +++ +L+ E  N       +  + +++ +  RV+DFFR IDKD  G+++R +FI  +  ++ P +  EM  V  + D +  G I Y + +  L   +   R    + ++  +  ++  V +   A+ F+  Q    K+
Sbjct: 4941 LDRQRKLHDALDRLEELK-EFANFDFDVWRKKYMRWMNHKKSRVMDFFRRIDKDQDGKITRQEFIDGILASKFPTSKLEMMAVADIFDRDGDGYIDYYEFVAALHPNKDAYRPTTDADKIEDEVTRQ--VAQCKCAKRFQVEQIGENKY 5086
[Close]
BLAST of Leucine rich repeat containing 74A vs. Ensembl Cavefish
Match: MACF1 (microtubule actin crosslinking factor 1 [Source:HGNC Symbol;Acc:HGNC:13664])

HSP 1 Score: 54.6842 bits (130), Expect = 1.498e-7
Identity = 36/149 (24.16%), Postives = 73/149 (48.99%), Query Frame = 2 
Query:  374 INRLRPFHVAYEKVLDLEDEIYNAKPKDPMEFLLEYLSDRAIRVVDFFRMIDKDGMGEVSRSKFIRNMKKNRVPLTSNEMQHVTSMIDENKSGMISYSKLIQKLRGYQKVVREKELSKRLTKDQKQEKIVIKAHIARLFEAGQFESPKF 820
            ++R R  H A +++ +L+ E  N       +  + +++ +  RV+DFFR IDKD  G+++R +FI  +  ++ P +  EM  V  + D +  G I Y + +  L   +   R    + ++  +  ++  V +   A+ F+  Q    K+
Sbjct: 5289 LDRQRKLHDALDRLEELK-EFANFDFDVWRKKYMRWMNHKKSRVMDFFRRIDKDQDGKITRQEFIDGILASKFPTSKLEMMAVADIFDRDGDGYIDYYEFVAALHPNKDAYRPTTDADKIEDEVTRQ--VAQCKCAKRFQVEQIGENKY 5434
[Close]
BLAST of Leucine rich repeat containing 74A vs. Ensembl Cavefish
Match: DST (dystonin [Source:HGNC Symbol;Acc:HGNC:1090])

HSP 1 Score: 53.1434 bits (126), Expect = 3.741e-7
Identity = 35/120 (29.17%), Postives = 58/120 (48.33%), Query Frame = 2 
Query:  473 LEYLSDRAIRVVDFFRMIDKDGMGEVSRSKFIRNMKKNRVPLTSNEMQHVTSMIDENKSGMISYSKLIQKLRGYQKVVREKELSKRLTKDQKQE----KIVIKAHIARLFEAGQFESPKF 820
            + +++ +  RV+DFFR IDKD  G+V+R +FI  +  ++ P +  EM  V  + D +  G I Y + +  L         K+  K LT   K E    + V K    + F+  Q  + K+
Sbjct: 1425 MRWMNHKKSRVMDFFRRIDKDQDGKVTRQEFIEGILSSKFPTSRLEMSAVADIFDRDGDGYIDYYEFVAALH------PNKDAYKPLTDADKIEDEVTRQVAKCKCPKRFQVEQIGANKY 1538
[Close]
BLAST of Leucine rich repeat containing 74A vs. Ensembl Cavefish
Match: lrrc45 (leucine rich repeat containing 45 [Source:NCBI gene;Acc:103038066])

HSP 1 Score: 50.8322 bits (120), Expect = 1.879e-6
Identity = 52/187 (27.81%), Postives = 85/187 (45.45%), Query Frame = 2 
Query:   38 VMQRIILDFVYISWN--GLAEDGSLGFERCLSNNVILEELNVKSNRINFESLYRIGKGLRRNRTLKILKIGLNNLTLAGILDLMDAANSAESGLEYVDLEGQYVHSKVLYLIEK-----INRLRPFHVAYEKVLDLEDEIYNAKPKDPMEFLLEYLSDRAIRVVDFFRMID--KDGMGEVSRSKFIR 571
             ++R++L+     WN  G+ E+G   F   L++N  L +L++++N+IN +    +   L+RN  L+ L +  NN+ L G   LMDA     S L+ +++ G  + S +L  IE+      +R         +   L  EI   K +   +FL                 ID  KD MG  SR+  IR
Sbjct:  119 TLRRLVLE-----WNALGMWEEGFSIFCEGLASNSCLTQLDLRNNQINHQGAAELALALKRNSVLQELDLRWNNIGLLGGRALMDALQQNRSLLQ-LEMAGNNIPSDILRSIEQSMEHNSDRQSTMRERRSRTHVLSKEIQILKEEKGRQFL------------SLMETIDKQKDEMGRSSRNSSIR 287
[Close]
BLAST of Leucine rich repeat containing 74A vs. Ensembl Sea Lamprey
Match: lrrc74a (leucine rich repeat containing 74A [Source:ZFIN;Acc:ZDB-GENE-131127-263])

HSP 1 Score: 96.2857 bits (238), Expect = 5.340e-23
Identity = 64/211 (30.33%), Postives = 108/211 (51.18%), Query Frame = 2 
Query:   56 LDFVYISWNGLAEDGSLGFERCLSNNVILEELNVKSNRINFESLYRIGKGLRRNRTLKILKIGLNNLTLAGILDLMDAANSAE-SGLEYVDLEGQYVHSKVLYLIEKINRLRPFHVAYEKVLDLEDEIYNAKPK---DPMEFLLEYLSDRAIRVVDFFRMIDKDGMGEVSRSKFIRNMKKNRVPLTSNEMQHVTSMIDENKSGMISYSKLI 676
            L  +++S NGL  +G+L     L  N  L  L++++NRI    +  + +GL  N +L++L++  N  T+ G L L+ A    E S LE +D+    V+   L+ +  I R +   V +  V          KPK   DPM+ + +YL +  +R+ DFFR  DK+G  ++S   F R ++   +PL  + +  +   ++ +K G I YS LI
Sbjct:   72 LTHLHLSVNGLGNEGALAMAEALKFNGALLHLDLRNNRIGNTGMEALARGLLTNDSLRVLQLCFNIFTVEGALVLIKAVKVNEHSALERLDMSTVRVNQGFLHTVSAIRRTQGLTVLHSGV----GGPLARKPKPRTDPMKLIQDYLVEHKLRLWDFFRSADKEGTMKISSDDFRRAVQHLSIPLDKHHLDELMLKLERDKDGRIDYSYLI 278
[Close]
BLAST of Leucine rich repeat containing 74A vs. Ensembl Sea Lamprey
Match: lrrc74a (leucine rich repeat containing 74A [Source:ZFIN;Acc:ZDB-GENE-131127-263])

HSP 1 Score: 93.2041 bits (230), Expect = 8.312e-22
Identity = 61/209 (29.19%), Postives = 106/209 (50.72%), Query Frame = 2 
Query:   56 LDFVYISWNGLAEDGSLGFERCLSNNVILEELNVKSNRINFESLYRIGKGLRRNRTLKILKIGLNNLTLAGILDLMDAANSAE-SGLEYVDLEGQYVHSKVLYLIEKINRLRPFHVAYEKVLDLEDEIYNAKPK---DPMEFLLEYLSDRAIRVVDFFRMIDKDGMGEVSRSKFIRNMKKNRVPLTSNEMQHVTSMIDENKSGMISYSK 670
            L  +++S NGL  +G+L     L  N  L  L++++NRI    +  + +GL  N +L++L++  N  T+ G L L+ A    E S LE +D+    V+   L+ +  I R +   V +  V          KPK   DPM+ + +YL +  +R+ DFFR  DK+G  ++S   F R ++   +PL  + +  +   ++ +K G I Y +
Sbjct:   72 LTHLHLSVNGLGNEGALAMAEALKFNGALLHLDLRNNRIGNTGMEALARGLLTNDSLRVLQLCFNIFTVEGALVLIKAVKVNEHSALERLDMSTVRVNQGFLHTVSAIRRTQGLTVLHSGV----GGPLARKPKPRTDPMKLIQDYLVEHKLRLWDFFRSADKEGTMKISSDDFRRAVQHLSIPLDKHHLDELMLKLERDKDGRIDYRR 276
[Close]
BLAST of Leucine rich repeat containing 74A vs. Ensembl Sea Lamprey
Match: ENSPMAT00000002444.1 (pep scaffold:Pmarinus_7.0:GL480979:320698:340261:-1 gene:ENSPMAG00000002230.1 transcript:ENSPMAT00000002444.1 gene_biotype:protein_coding transcript_biotype:protein_coding)

HSP 1 Score: 80.1073 bits (196), Expect = 6.525e-17
Identity = 53/205 (25.85%), Postives = 101/205 (49.27%), Query Frame = 2 
Query:   62 FVYISWNGLAEDGSLGFERCLSNNVILEELNVKSNRINFESLYRIGKGLRRNRTLKILKIGLNNLTLAGILDLMDA-ANSAESGLEYVDLEGQYVHSKVLYLIEKINRLRP--FHVAYEKVLDLEDEIYNAKPK-DPMEFLLEYLSDRAIRVVDFFRMIDKDGMGEVSRSKFIRNMKKNRVPLTSNEMQHVTSMIDENKSGMISY 664
            ++ ++W G+  +G+L     L  N  L  L++ S R++      +  GL+ N  L+ LK+ LN +   G L L+ A   +  S ++ +++    V+ + + L+  +   RP   HV +  V       +  +P+  PM+ +  +L    +R+ DFFR +DK G   V++  F   M++   PL    ++ + S +D + SG I+Y
Sbjct:  146 WLSLAWTGVGIEGALALREALQRNRTLHHLDLSSCRVDERGARALAAGLQTNVALRSLKLALNPIMAEGALALLSAIQKNKRSTMQDLNISNVVVNEQFVQLLSAMRAERPRAMHVRHGGVGSGLRRTF--QPRVSPMQAIQGHLLKNKLRLWDFFRNMDKSGTMSVTQDVFRSAMQQLSTPLEEQALEELISALDRDGSGWINY 348
[Close]
BLAST of Leucine rich repeat containing 74A vs. Ensembl Sea Lamprey
Match: MACF1 (microtubule actin crosslinking factor 1 [Source:HGNC Symbol;Acc:HGNC:13664])

HSP 1 Score: 51.9878 bits (123), Expect = 2.210e-7
Identity = 25/79 (31.65%), Postives = 43/79 (54.43%), Query Frame = 2 
Query:  473 LEYLSDRAIRVVDFFRMIDKDGMGEVSRSKFIRNMKKNRVPLTSNEMQHVTSMIDENKSGMISYSKLIQKLRGYQKVVR 709
            +++++ +  RV+DFFR +DKD  G+++R +FI  +  +R P    EM  V  + D +  G I Y + I  L   +   R
Sbjct: 3053 MQWMNHKKSRVMDFFRRMDKDQDGKITRQEFIDGILSSRFPTNRLEMTAVADIFDRDGDGYIDYYEFIAALHPNKDAYR 3131
[Close]
BLAST of Leucine rich repeat containing 74A vs. Ensembl Nematostella
Match: EDO31618 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7SXE5])

HSP 1 Score: 124.79 bits (312), Expect = 3.899e-32
Identity = 69/220 (31.36%), Postives = 124/220 (56.36%), Query Frame = 2 
Query:   20 VGMKFEVMQRIILDFVYISWNGLAEDGSLGFERCLSNNVILEELNVKSNRINFESLYRIGKGLRRNRTLKILKIGLNNLTLAGILDLMDAAN-SAESGLEYVDLEGQYVHSKVLYLIEKINRLRP-FHVAYEKVLDLEDEIYNAKPKDPMEFLLEYLSDRAIRVVDFFRMIDKDGMGEVSRSKFIRNMKKNRVPLTSNEMQHVTSMIDENKSGMISYSKL 673
            V + + +     L  + +SWNG A+DG+      L+ N  L EL++ SNRI+ E    I  GL +N TL+IL+IG+N     G  D++ A + +  S +E +  +   V+S+    +E++   RP   V     +  +D +   K +D +  LLEY+  R +R+VDFFR +DKD   +++R++F+  +KK  +P+T  +++ + +++D +  G I YS++
Sbjct:  182 VAIGYGLRHNCSLKSLDLSWNGFADDGAKSVGEALALNTTLTELDISSNRISGEGASSIAAGLAKNETLQILRIGINPFLSQGAQDILSAVHQNPNSAIEELGFDDIPVNSEFEDFLEEVMDARPNLSVQCGAAMRGKDRVKKIKQRDVLNLLLEYIELRGLRMVDFFRQLDKDNSKKITRAEFMAGVKKTGIPMTRRQLKKLVNILDVDNDGNIDYSEI 401
[Close]
BLAST of Leucine rich repeat containing 74A vs. Ensembl Nematostella
Match: EDO36360 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7SIU1])

HSP 1 Score: 110.153 bits (274), Expect = 7.898e-27
Identity = 67/211 (31.75%), Postives = 115/211 (54.50%), Query Frame = 2 
Query:   71 ISWNGLAEDGSLGFERCLSNNVILEELNVKSNRINFESLYRIGKGLRRNRTLKILKIGLNNLTLAGILDLMDAA-NSAESGLEYVDLEGQYVHSKVLYLIEKINRLRP-FHVAY-----EKVLDLEDEIYNAKPKDPMEFLL---EYLSDRAIRVVDFFRMIDKDGMGEVSRSKFIRNMKKNRVPLTSNEMQHVTSMIDENKSGMISYSKL 673
            +SWNG A+DG+      L +N  L+EL++  NRI  +  + + KGL  N  L++LKIG N     G + L+ A  N+A+S +E + L    V   VL  +++  +  P F +       ++   ++D+  N K K   + L    EYL ++ +R VD F  +DKD    VS  + I  +K+ R+PLT ++++ + +++D++  GMI YS+ 
Sbjct:  211 LSWNGFADDGAAAMGNALRHNSTLKELDLSHNRITKKGAFALSKGLAVNDALRVLKIGFNPFESDGTMALLKAMRNNAKSAMEELHLNNITVGKGVLEFLDEYMKHNPNFQITLGVSPTDRREAMDDDDKNGKMKSKNQLLTILKEYLIEKRLRAVDLFNCLDKDKSRSVSPEELIEGLKRARIPLTDSQLKRLITLLDKDGDGMIDYSEF 421
[Close]
BLAST of Leucine rich repeat containing 74A vs. Ensembl Nematostella
Match: EDO31478 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7SXT1])

HSP 1 Score: 104.76 bits (260), Expect = 4.990e-25
Identity = 73/227 (32.16%), Postives = 116/227 (51.10%), Query Frame = 2 
Query:    8 CLI*VGMKFEVMQRIILDFVYISWNGLAEDGSLGFERCLSNNVILEELNVKSNRINFESLYRIGKGLRRNRTLKILKIGLNNLTLAGILDLMDA-ANSAESGLEYVDLEGQYVHSKVLYLIEKINRLRP----FHVAYEKVLDLEDEIYNAKPKD---PMEFLLEYLSDRAIRVVDFFRMIDKDGMGEVSRSKFIRNMKKNRVPLTSNEMQHVTSMIDENKSGMISY 664
            C I + +K    + I L  + ++WNG   DG+L     L  N  L EL++ +NRI  E    +GKGL  N TL++LKIG N +  AG   +++A  N+ ES L  V+L    V++  L L  ++   RP     H      L         KPK    PM+ L  Y+SD  +R++DFF  +DKD    ++  +F+  +K+  + +   E+ ++   +D+NK G I+Y
Sbjct:  195 CAIALSLK----ENITLKILNLAWNGFGNDGALAMGEALKVNASLLELDLTNNRITAEGAVLLGKGLTINTTLQVLKIGKNPMQSAGAYAILNAMKNNPESALVEVELSDITVNNDFLQLCGEVIAARPNVKITHGGSGGALH--------KPKGRPAPMKILKNYISDNRMRLLDFFNTLDKDKSMSLTIKEFVDGLKETGIDMNYVELFNLIETLDKNKDGEINY 409
[Close]
BLAST of Leucine rich repeat containing 74A vs. Ensembl Nematostella
Match: EDO36359 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7SIU0])

HSP 1 Score: 105.531 bits (262), Expect = 5.681e-25
Identity = 69/222 (31.08%), Postives = 115/222 (51.80%), Query Frame = 2 
Query:   71 ISWNGLAEDGSLGFERCLSNNVILEELNVKSNRINFESLYRIGKGLRRNRTLKILKIGLNNLTLAGILDLMDAA-NSAESGLEYVDLEGQYVHSKVLYLIEKINRLRPFHVAYEKVLDLEDEIYN-AKPKDPMEFLLEYLSDRAIRVVDFFRMIDKDGMGEVSRSKFIRNMKKNRVPLTSNEMQHVTSMIDENKSGMISYSKLIQKLRGYQKVVREKELSKR 730
            ++WNG+A DG++   + L  N  L EL++ SNR+  E      + L+ N +L+ L    NN+T  G   L++A   S+ S +  +DL G  +      L+E++  ++P  V    V D+  E  + A   DP   L  YL+   +RVVD FR +DKD   +VS  +F+  ++K+ V LT+ E++ +   +D +  G I YS+ +  ++G  K    K    R
Sbjct:  273 LAWNGVATDGAIALAKSLEGNTTLVELDLSSNRVGDEGAIAFARTLKNNSSLESLYAAKNNITENGACSLLNAVMQSSGSTMIKIDLTGAILKDDFHSLVEELKIVKPEMVV---VTDICPEPRSRADTPDPSTLLRNYLAREHVRVVDLFRRLDKDQSMQVSVREFVEGLRKSDVGLTAFEVEKIIESLDVDDDGEIDYSEFVS-IQGMWKSPESKGARSR 490
[Close]
BLAST of Leucine rich repeat containing 74A vs. Ensembl Nematostella
Match: EDO31006 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7SZ62])

HSP 1 Score: 99.7525 bits (247), Expect = 7.597e-23
Identity = 69/219 (31.51%), Postives = 114/219 (52.05%), Query Frame = 2 
Query:   56 LDFVYISWNGLAEDGSLGFERCLSNNVILEELNVKSNRINFESLYRIGKGLRRNRTLKILKIGLNNLTLAGILDLMDAA-NSAESGLEYVDLEGQYVHSKVLYLIEKINRLRP-FHVAYEK------VLDLEDEIYNAKPK-----DPMEFLLEYLSDRAIRVVDFFRMIDKDGMGEVSRSKFIRNMKKNRVPLTSNEMQHVTSMIDENKSGMISYSKL 673
            L  + +SWNG A++G+      L +N  L EL++  NRI  +    + +GL+ N TLK+LKIG+N +   G   L+DA  N+AE  +E V L    +  +  +LIE+I   RP F VA  K      V++  + +++   K     + +  L EY+     R+VD F   DKD    V+R +F   +K   VP++  ++  +  ++DE+  G I +S+ 
Sbjct:  319 LQVLDLSWNGFADEGAHAVGESLKDNNTLLELDLSYNRITCKGALALAEGLKINNTLKVLKIGMNMIQNKGANALLDAMRNNAECAMEKVYLNNVVIDVETNHLIEQILETRPNFVVACTKSKRSGDVMNQLNAMFSGDTKKKKILELINMLKEYVERMNYRLVDLFNQFDKDNSLSVTRDEFYTGLKGIGVPMSDKDLTMLIDLLDEDGDGEIDFSEF 537
[Close]
BLAST of Leucine rich repeat containing 74A vs. Ensembl Medaka
Match: lrrc74a (leucine rich repeat containing 74A [Source:ZFIN;Acc:ZDB-GENE-131127-263])

HSP 1 Score: 82.4185 bits (202), Expect = 6.848e-17
Identity = 67/218 (30.73%), Postives = 114/218 (52.29%), Query Frame = 2 
Query:   20 VGMKFEVMQRIILDFVYISWNGLAEDGSLGFERCLSNNVILEELNVKSNRINFESLYRIGKGLRRNRTLKILKIGLNNLTLAGILDLMD-AANSAESGLEYVDLEGQYVHSKVLYLIEKINRLRP-FHVAYEKVLDLEDEIYNAKPK---DPMEFLLEYLSDRAIRVVDFFRMIDKDGMGEVSRSKFIRNMKKNRVPLTSNEMQHVTSMIDENKSGMI 658
             G+K   M    L  + +SWNG   DG+L     L  N  L  LN+ +NR+  E +  + +GL  N TL++     N+LT+ G L L++   N+ ++ L+ +DL    V+   ++L+E   +  P   V Y  V          KP+   DPM+ + +YL  R +R+ DFFR IDKDG  +V  + F R ++++ +PL   +++ +   +D  ++GM+
Sbjct:  181 AGLKVNTM----LKHLDLSWNGFGNDGALAIGEALKFNNTLVHLNLNNNRLTNEGVSMLCRGLEYNDTLQL---AYNSLTVEGALVLVNIVKNTPKTALDEIDL---CVNQNFVHLLEVTRQEHPGLKVHYRGV----GGFIAKKPQKRIDPMKVVQDYLDKRKLRLWDFFRNIDKDGTMQVPVTDFRRAIQQSSIPLDGYQVEELIQRLDRGRTGMV 384
[Close]
BLAST of Leucine rich repeat containing 74A vs. Ensembl Medaka
Match: ENSORLT00000034832.1 (pep primary_assembly:ASM223467v1:11:16837571:16849096:-1 gene:ENSORLG00000026542.1 transcript:ENSORLT00000034832.1 gene_biotype:protein_coding transcript_biotype:protein_coding)

HSP 1 Score: 52.373 bits (124), Expect = 4.176e-7
Identity = 28/111 (25.23%), Postives = 55/111 (49.55%), Query Frame = 2 
Query:  473 LEYLSDRAIRVVDFFRMIDKDGMGEVSRSKFIRNMKKNRVPLTSNEMQHVTSMIDENKSGMISYSKLIQKLR----GYQKVVREKELSKRLTKDQKQEKIVIKAHIARLFE 793
            + +++ +  RV+DFFR IDKD  G+++R +FI  +  ++ P +  EM  V  + D +  G I Y + +  L      Y+      ++   +T+   Q K   +  + ++ E
Sbjct:    1 MRWMNHKKSRVMDFFRRIDKDQDGKITRQEFIDGILASKFPTSKLEMTAVADIFDRDGDGYIDYYEFVAALHPNKDAYRPTTDADKIEDEVTRQVAQCKCAKRFQVEQIGE 111
[Close]
BLAST of Leucine rich repeat containing 74A vs. Planmine SMEST
Match: SMESG000008632.1 (SMESG000008632.1)

HSP 1 Score: 602.053 bits (1551), Expect = 0.000e+0
Identity = 305/305 (100.00%), Postives = 305/305 (100.00%), Query Frame = 2 
Query:   71 ISWNGLAEDGSLGFERCLSNNVILEELNVKSNRINFESLYRIGKGLRRNRTLKILKIGLNNLTLAGILDLMDAANSAESGLEYVDLEGQYVHSKVLYLIEKINRLRPFHVAYEKVLDLEDEIYNAKPKDPMEFLLEYLSDRAIRVVDFFRMIDKDGMGEVSRSKFIRNMKKNRVPLTSNEMQHVTSMIDENKSGMISYSKLIQKLRGYQKVVREKELSKRLTKDQKQEKIVIKAHIARLFEAGQFESPKFISTTSSATTRRDNVLPPIPKLIHXXXXXXXXVIIYSRSKSLKDERISTLVKIYPN 985
            ISWNGLAEDGSLGFERCLSNNVILEELNVKSNRINFESLYRIGKGLRRNRTLKILKIGLNNLTLAGILDLMDAANSAESGLEYVDLEGQYVHSKVLYLIEKINRLRPFHVAYEKVLDLEDEIYNAKPKDPMEFLLEYLSDRAIRVVDFFRMIDKDGMGEVSRSKFIRNMKKNRVPLTSNEMQHVTSMIDENKSGMISYSKLIQKLRGYQKVVREKELSKRLTKDQKQEKIVIKAHIARLFEAGQFESPKFISTTSSATTRRDNVLPPIPKLIHKNNYNNKKVIIYSRSKSLKDERISTLVKIYPN
Sbjct:  223 ISWNGLAEDGSLGFERCLSNNVILEELNVKSNRINFESLYRIGKGLRRNRTLKILKIGLNNLTLAGILDLMDAANSAESGLEYVDLEGQYVHSKVLYLIEKINRLRPFHVAYEKVLDLEDEIYNAKPKDPMEFLLEYLSDRAIRVVDFFRMIDKDGMGEVSRSKFIRNMKKNRVPLTSNEMQHVTSMIDENKSGMISYSKLIQKLRGYQKVVREKELSKRLTKDQKQEKIVIKAHIARLFEAGQFESPKFISTTSSATTRRDNVLPPIPKLIHKNNYNNKKVIIYSRSKSLKDERISTLVKIYPN 527

HSP 2 Score: 51.9878 bits (123), Expect = 5.090e-7
Identity = 22/23 (95.65%), Postives = 23/23 (100.00%), Query Frame = 1 
Query:    1 LKLLDISWNEIRGDAAYYFGLCI 69
            LKLLDISWNEIRGDAAYYFGLC+
Sbjct:  190 LKLLDISWNEIRGDAAYYFGLCM 212
[Close]
BLAST of Leucine rich repeat containing 74A vs. Planmine SMEST
Match: SMESG000073508.1 (SMESG000073508.1)

HSP 1 Score: 72.7886 bits (177), Expect = 4.473e-14
Identity = 59/206 (28.64%), Postives = 104/206 (50.49%), Query Frame = 2 
Query:   71 ISWNGLAEDGSLGFERCLSNNVILEELNVKSNRINFESLYRIGKGLRRNRTLKILKIGLNNLTLAGILDLMDAANSAES----GLEYVDLEGQYVHSKVLYLIEKINR-LRPFHVAYEKVLDLEDEIYN--AKPKDPMEFLLEYLSDRAIRVVDFFRMIDKDGMGEVSRSKFIRNMKKNRVPLTSNEMQHVTSMIDENKSGMISYS 667
            +S+NG A+DG       L +N  L  LN++SNRI+ E+   IGK L+ N TLK L+IG N +   GIL LM + NS ++     L   ++   +  SKV+  I+   R  +  H     V + +++I       K  +  L E++  +  R++D    ID+D    V+  +F + +++  +P    ++  + + +D+  +G I Y 
Sbjct:  176 LSYNGFAKDGGFALADTLKDNSALIVLNIESNRIDGETAALIGKALKSNETLKELRIGNNTIDTNGILSLMSSINSYDASPLRSLYLTNVPIDFEISKVIEHIQLKRRDFKCIHGFEIGVGNTQEDIRKRLTNYKHILILLKEHVLIKDKRLIDILMKIDEDNKKFVTLEQFSQALQELGIPFKKVQLNDIKNQLDKLGNGTIYYG 381

HSP 2 Score: 23.483 bits (49), Expect = 4.473e-14
Identity = 9/16 (56.25%), Postives = 13/16 (81.25%), Query Frame = 1 
Query:    1 LKLLDISWNEIRGDAA 48
            L+ LD+SWN+IR + A
Sbjct:  143 LEYLDLSWNQIRREGA 158
[Close]
BLAST of Leucine rich repeat containing 74A vs. Planmine SMEST
Match: SMESG000008282.1 (SMESG000008282.1)

HSP 1 Score: 64.3142 bits (155), Expect = 2.964e-11
Identity = 60/240 (25.00%), Postives = 112/240 (46.67%), Query Frame = 2 
Query:   41 MQRIILDFVYISWNGLAEDGSLGFERCLSNNVILEELNVKSNRINFESLYRIGKGLRRNRTLKILKIGLNNLTLAGILDLMDA---ANSAESGLEYVDLEGQYVHSKVLYLIEKINRLRPFHVAYEKVLDLEDEIYNAK---PKDPME----FLLEYLSDRAIRVVDFFRMIDKDGMGEVSRSKFIRNMKKNRVPLTSNEMQHVTSMIDENKSGMISYSKLIQKLRGY-QKVVREKELSK 727
            ++R+IL+     WNG  + G+    + L  N  LEEL +  NRI       I K L +N TLKILKIG N+++ +   D + +    +   S +  +D +     +    ++E + ++ P    Y       D  Y  +     DP++    F+  Y+    I +V+ F   D D    V+ ++F   +K+  +P+  N++  +   +D +  G I +S+L+     + QK  + ++L+K
Sbjct:  280 LKRLILN-----WNGFEDSGTKELSQSLLENEDLEELEIACNRITDVGFANILKSLEKNVTLKILKIGWNSISQSAAEDALKSFREGSLKSSTIRTLDFKNIIFRNNFQNVVESLQKVLPEFQCYFGY----DSSYGKRKLQSYDPVDEALRFMKVYIETHHINLVELFEKFDVDQSMSVTYNEFREGLKEAGIPINDNQINQLIQYLDSDGDGEIDFSELVIGAETHAQKEAKHEDLTK 510

HSP 2 Score: 22.7126 bits (47), Expect = 2.964e-11
Identity = 8/16 (50.00%), Postives = 14/16 (87.50%), Query Frame = 1 
Query:    1 LKLLDISWNEIRGDAA 48
            L++LD+SWN++R + A
Sbjct:  252 LEVLDLSWNQLRLEGA 267
[Close]
BLAST of Leucine rich repeat containing 74A vs. Planmine SMEST
Match: SMESG000008282.1 (SMESG000008282.1)

HSP 1 Score: 64.3142 bits (155), Expect = 2.985e-11
Identity = 60/240 (25.00%), Postives = 112/240 (46.67%), Query Frame = 2 
Query:   41 MQRIILDFVYISWNGLAEDGSLGFERCLSNNVILEELNVKSNRINFESLYRIGKGLRRNRTLKILKIGLNNLTLAGILDLMDA---ANSAESGLEYVDLEGQYVHSKVLYLIEKINRLRPFHVAYEKVLDLEDEIYNAK---PKDPME----FLLEYLSDRAIRVVDFFRMIDKDGMGEVSRSKFIRNMKKNRVPLTSNEMQHVTSMIDENKSGMISYSKLIQKLRGY-QKVVREKELSK 727
            ++R+IL+     WNG  + G+    + L  N  LEEL +  NRI       I K L +N TLKILKIG N+++ +   D + +    +   S +  +D +     +    ++E + ++ P    Y       D  Y  +     DP++    F+  Y+    I +V+ F   D D    V+ ++F   +K+  +P+  N++  +   +D +  G I +S+L+     + QK  + ++L+K
Sbjct:  300 LKRLILN-----WNGFEDSGTKELSQSLLENEDLEELEIACNRITDVGFANILKSLEKNVTLKILKIGWNSISQSAAEDALKSFREGSLKSSTIRTLDFKNIIFRNNFQNVVESLQKVLPEFQCYFGY----DSSYGKRKLQSYDPVDEALRFMKVYIETHHINLVELFEKFDVDQSMSVTYNEFREGLKEAGIPINDNQINQLIQYLDSDGDGEIDFSELVIGAETHAQKEAKHEDLTK 530

HSP 2 Score: 22.7126 bits (47), Expect = 2.985e-11
Identity = 8/16 (50.00%), Postives = 14/16 (87.50%), Query Frame = 1 
Query:    1 LKLLDISWNEIRGDAA 48
            L++LD+SWN++R + A
Sbjct:  272 LEVLDLSWNQLRLEGA 287
[Close]
BLAST of Leucine rich repeat containing 74A vs. Planmine SMEST
Match: SMESG000006391.1 (SMESG000006391.1)

HSP 1 Score: 64.3142 bits (155), Expect = 3.161e-11
Identity = 50/210 (23.81%), Postives = 93/210 (44.29%), Query Frame = 2 
Query:   56 LDFVYISWNGLAE-DGSLGFERCLSNNVILEELNVKSNRINFESLYRIGKGLRRNRTLKILKIGLNNLTLAGILDLMDAA-NSAESGLEYVDLEGQYVHSKVLYLIEKINRLRPFHVAYEKVLDLEDEIYNAKPKDPMEFLLEYLSDRAIRVVDFFRMIDKDGMGEVSRSKFIRNMKKNRVPLTSNEMQHVTSMIDENKSGMISYSKLIQ 679
            L  + +SWNGL    G   F + L  N  LEE+++ +NRI  E    +G+GL  N TLK LKIG N +  AG   ++     ++ + +  +D E   V+   + L  ++           K       I+      P+  L  ++    + ++ +F   D      +++  F   ++     LT NE++ +   +D+ ++G I Y   ++
Sbjct:  122 LKVLNLSWNGLGSIPGMQDFGKMLKTNTTLEEIDISNNRITTEGAVLLGRGLSVNCTLKTLKIGSNPMQTAGCYAILSTILKNSNTAISLLDFENIRVNQDFVDLKSELPTTMSVLAGSRKPARPSSSIH------PIVRLKTFVRKHKLPLIKYFNHFDDAENMNLTKHDFRLCLQDTNFDLTENELERLIEHLDKKQNGFIYYKDFME 325
The following BLAST results are available for this feature:
BLAST of Leucine rich repeat containing 74A vs. Ensembl Human
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Human e!99)
Total hits: 5
Match NameE-valueIdentityDescription
LRRC74A8.669e-1527.45leucine rich repeat containing 74A [Source:HGNC Sy... [more]
LRRC74B9.863e-931.30leucine rich repeat containing 74B [Source:HGNC Sy... [more]
DST3.192e-725.83dystonin [Source:HGNC Symbol;Acc:HGNC:1090][more]
MACF13.197e-726.13microtubule actin crosslinking factor 1 [Source:HG... [more]
DST3.347e-725.83dystonin [Source:HGNC Symbol;Acc:HGNC:1090][more]
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BLAST of Leucine rich repeat containing 74A vs. Ensembl Celegans
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99)
Total hits: 0
Match NameE-valueIdentityDescription
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BLAST of Leucine rich repeat containing 74A vs. Ensembl Fly
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99)
Total hits: 5
Match NameE-valueIdentityDescription
shot7.736e-631.51gene:FBgn0013733 transcript:FBtr0087621[more]
shot8.474e-631.51gene:FBgn0013733 transcript:FBtr0087616[more]
shot8.475e-631.51gene:FBgn0013733 transcript:FBtr0304850[more]
shot8.621e-631.51gene:FBgn0013733 transcript:FBtr0273222[more]
shot8.854e-631.51gene:FBgn0013733 transcript:FBtr0273225[more]
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BLAST of Leucine rich repeat containing 74A vs. Ensembl Zebrafish
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99)
Total hits: 5
Match NameE-valueIdentityDescription
lrrc74a2.650e-2430.54leucine rich repeat containing 74A [Source:ZFIN;Ac... [more]
lrrc74b1.039e-1240.43leucine rich repeat containing 74B [Source:ZFIN;Ac... [more]
macf1a9.793e-725.00microtubule actin crosslinking factor 1a [Source:Z... [more]
macf1a9.857e-725.00microtubule actin crosslinking factor 1a [Source:Z... [more]
DST1.207e-629.17dystonin [Source:HGNC Symbol;Acc:HGNC:1090][more]
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BLAST of Leucine rich repeat containing 74A vs. Ensembl Xenopus
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99)
Total hits: 5
Match NameE-valueIdentityDescription
ENSXETT00000010017.15.425e-935.79pep primary_assembly:Xenopus_tropicalis_v9.1:1:141... [more]
rab11fip21.424e-725.83RAB11 family interacting protein 2 (class I) [Sour... [more]
rab11fip21.478e-725.83RAB11 family interacting protein 2 (class I) [Sour... [more]
rab11fip21.584e-725.83RAB11 family interacting protein 2 (class I) [Sour... [more]
rab11fip21.895e-725.83RAB11 family interacting protein 2 (class I) [Sour... [more]
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BLAST of Leucine rich repeat containing 74A vs. Ensembl Mouse
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99)
Total hits: 5
Match NameE-valueIdentityDescription
Lrrc74a9.102e-1426.47leucine rich repeat containing 74A [Source:MGI Sym... [more]
Lrrc74a1.736e-1325.11leucine rich repeat containing 74A [Source:MGI Sym... [more]
Dst4.649e-825.83dystonin [Source:MGI Symbol;Acc:MGI:104627][more]
Lrrc74b1.276e-732.17leucine rich repeat containing 74B [Source:MGI Sym... [more]
Dst2.153e-725.83dystonin [Source:MGI Symbol;Acc:MGI:104627][more]
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BLAST of Leucine rich repeat containing 74A vs. UniProt/SwissProt
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt)
Total hits: 5
Match NameE-valueIdentityDescription
sp|Q0VAA2|LR74A_HUMAN4.163e-1427.45Leucine-rich repeat-containing protein 74A OS=Homo... [more]
sp|A0JPI9|LR74A_RAT4.185e-1225.25Leucine-rich repeat-containing protein 74A OS=Ratt... [more]
sp|Q6ZQY2|LR74B_HUMAN4.265e-831.30Leucine-rich repeat-containing protein 74B OS=Homo... [more]
sp|Q14BP6|LR74B_MOUSE2.577e-732.17Leucine-rich repeat-containing protein 74B OS=Mus ... [more]
sp|Q91ZU6|DYST_MOUSE1.546e-625.83Dystonin OS=Mus musculus OX=10090 GN=Dst PE=1 SV=2[more]
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BLAST of Leucine rich repeat containing 74A vs. TrEMBL
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL)
Total hits: 5
Match NameE-valueIdentityDescription
A0A4V3SDS24.129e-3735.75Uncharacterized protein OS=Opisthorchis felineus O... [more]
A0A3R7HBG01.959e-3635.29Leucine-rich repeat-containing protein 74A OS=Clon... [more]
A0A075A9S43.271e-3534.84Uncharacterized protein (Fragment) OS=Opisthorchis... [more]
A0A1S8X8V73.870e-3534.84Leucine Rich repeat-containing domain protein (Fra... [more]
A0A2T7NX654.946e-3433.33Uncharacterized protein OS=Pomacea canaliculata OX... [more]
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BLAST of Leucine rich repeat containing 74A vs. Ensembl Cavefish
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99)
Total hits: 5
Match NameE-valueIdentityDescription
lrrc74a1.688e-2529.67leucine rich repeat containing 74A [Source:NCBI ge... [more]
MACF11.456e-724.16microtubule actin crosslinking factor 1 [Source:HG... [more]
MACF11.498e-724.16microtubule actin crosslinking factor 1 [Source:HG... [more]
DST3.741e-729.17dystonin [Source:HGNC Symbol;Acc:HGNC:1090][more]
lrrc451.879e-627.81leucine rich repeat containing 45 [Source:NCBI gen... [more]
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BLAST of Leucine rich repeat containing 74A vs. Ensembl Sea Lamprey
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99)
Total hits: 4
Match NameE-valueIdentityDescription
lrrc74a5.340e-2330.33leucine rich repeat containing 74A [Source:ZFIN;Ac... [more]
lrrc74a8.312e-2229.19leucine rich repeat containing 74A [Source:ZFIN;Ac... [more]
ENSPMAT00000002444.16.525e-1725.85pep scaffold:Pmarinus_7.0:GL480979:320698:340261:-... [more]
MACF12.210e-731.65microtubule actin crosslinking factor 1 [Source:HG... [more]
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BLAST of Leucine rich repeat containing 74A vs. Ensembl Yeast
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46)
Total hits: 0
Match NameE-valueIdentityDescription
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BLAST of Leucine rich repeat containing 74A vs. Ensembl Nematostella
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46)
Total hits: 5
Match NameE-valueIdentityDescription
EDO316183.899e-3231.36Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7... [more]
EDO363607.898e-2731.75Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7... [more]
EDO314784.990e-2532.16Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7... [more]
EDO363595.681e-2531.08Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7... [more]
EDO310067.597e-2331.51Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7... [more]
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BLAST of Leucine rich repeat containing 74A vs. Ensembl Medaka
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99)
Total hits: 2
Match NameE-valueIdentityDescription
lrrc74a6.848e-1730.73leucine rich repeat containing 74A [Source:ZFIN;Ac... [more]
ENSORLT00000034832.14.176e-725.23pep primary_assembly:ASM223467v1:11:16837571:16849... [more]
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BLAST of Leucine rich repeat containing 74A vs. Planmine SMEST
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST)
Total hits: 5
Match NameE-valueIdentityDescription
SMESG000008632.15.090e-7100.00SMESG000008632.1[more]
SMESG000073508.14.473e-1428.64SMESG000073508.1[more]
SMESG000008282.12.964e-1125.00SMESG000008282.1[more]
SMESG000008282.12.985e-1125.00SMESG000008282.1[more]
SMESG000006391.13.161e-1123.81SMESG000006391.1[more]
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Sequences
The following sequences are available for this feature:

transcript sequence

>SMED30011349 ID=SMED30011349|Name=Leucine rich repeat containing 74A|organism=Schmidtea mediterranea sexual|type=transcript|length=1170bp
CTCAAATTGCTTGATATAAGTTGGAATGAAATTCGAGGTGATGCAGCGTA
TTATTTTGGACTTTGTATATATTTCTTGGAATGGTTTAGCTGAGGATGGA
AGCTTGGGATTTGAAAGATGCCTCTCTAATAATGTGATCCTAGAGGAATT
GAATGTGAAAAGTAACAGAATAAATTTTGAATCTCTTTATCGAATAGGAA
AAGGTCTGAGAAGAAATCGAACTTTAAAAATACTAAAGATTGGTCTGAAT
AACTTAACGCTGGCTGGCATTCTTGATTTAATGGATGCTGCTAATTCCGC
AGAATCCGGATTGGAATACGTGGATCTAGAAGGCCAGTACGTTCATTCAA
AGGTGCTTTACTTGATCGAAAAAATTAATAGACTAAGGCCTTTTCATGTA
GCCTATGAAAAGGTTTTAGATTTAGAAGATGAAATTTATAATGCAAAGCC
AAAAGATCCAATGGAATTTTTATTGGAGTACTTATCAGACCGAGCAATTC
GAGTGGTTGACTTTTTCCGAATGATTGACAAAGATGGAATGGGAGAGGTG
TCCAGGAGCAAGTTTATCAGAAACATGAAGAAAAATCGTGTCCCTCTCAC
GAGCAATGAGATGCAACATGTCACCTCAATGATTGACGAGAACAAATCCG
GAATGATTTCTTATAGTAAATTAATTCAAAAATTACGAGGATATCAAAAA
GTTGTCAGAGAAAAAGAGCTATCAAAAAGATTAACTAAAGATCAAAAACA
AGAGAAAATAGTTATTAAAGCTCATATTGCAAGATTATTCGAAGCTGGGC
AGTTTGAGAGCCCTAAATTCATTTCAACTACTTCATCAGCGACTACAAGA
CGAGATAACGTGTTGCCTCCAATTCCAAAACTAATTCATAAAAATAATTA
CAACAATAAAAAAGTTATAATTTATTCAAGAAGTAAAAGTCTAAAAGATG
AACGAATTTCAACACTTGTAAAGATTTATCCTAACTAAATAGTTAATATA
AAATTGATGATAATAATTTACAGTTCAAATTTTTATTTATATTAAATTTA
AAAAAACAGCAATAACCTTTGAACAATTAACGAATATCTCTGGTTGTCTA
AATAGGATTGGAACGTTTAGGTTGGCTTAGAAATCGTTTTACCTACTGTT
AGTGGCTGCTTTCTCATTGG
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protein sequence of SMED30011349-orf-1

>SMED30011349-orf-1 ID=SMED30011349-orf-1|Name=SMED30011349-orf-1|organism=Schmidtea mediterranea sexual|type=polypeptide|length=321bp
MKFEVMQRIILDFVYISWNGLAEDGSLGFERCLSNNVILEELNVKSNRIN
FESLYRIGKGLRRNRTLKILKIGLNNLTLAGILDLMDAANSAESGLEYVD
LEGQYVHSKVLYLIEKINRLRPFHVAYEKVLDLEDEIYNAKPKDPMEFLL
EYLSDRAIRVVDFFRMIDKDGMGEVSRSKFIRNMKKNRVPLTSNEMQHVT
SMIDENKSGMISYSKLIQKLRGYQKVVREKELSKRLTKDQKQEKIVIKAH
IARLFEAGQFESPKFISTTSSATTRRDNVLPPIPKLIHKNNYNNKKVIIY
SRSKSLKDERISTLVKIYPN*
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Annotated Terms
The following terms have been associated with this transcript:
Vocabulary: Planarian Anatomy
TermDefinition
PLANA:0000099neuron
PLANA:0000418head
PLANA:0000464GABAergic neuron
Vocabulary: INTERPRO
TermDefinition
IPR011992EF-hand-dom_pair
IPR032675LRR_dom_sf
IPR002048EF_hand_dom
Vocabulary: molecular function
TermDefinition
GO:0005509calcium ion binding
GO:0000166nucleotide binding
GO:0003779actin binding
GO:0005515protein binding
GO:0005524ATP binding
GO:0016888endodeoxyribonuclease activity, producing 5'-phosphomonoesters
GO:0019899enzyme binding
GO:0019901protein kinase binding
GO:0030544Hsp70 protein binding
GO:0032500muramyl dipeptide binding
GO:0042834peptidoglycan binding
GO:0050700CARD domain binding
GO:0051879Hsp90 protein binding
Vocabulary: biological process
TermDefinition
GO:0002227innate immune response in mucosa
GO:0002253activation of immune response
GO:0002367cytokine production involved in immune response
GO:0002374cytokine secretion involved in immune response
GO:0002376immune system process
GO:0002381immunoglobulin production involved in immunoglobulin mediated immune response
GO:0002606positive regulation of dendritic cell antigen processing and presentation
GO:0002710negative regulation of T cell mediated immunity
GO:0002830positive regulation of type 2 immune response
GO:0002862negative regulation of inflammatory response to antigenic stimulus
GO:0002925positive regulation of humoral immune response mediated by circulating immunoglobulin
GO:0006259DNA metabolic process
GO:0006952defense response
GO:0006954inflammatory response
GO:0006963positive regulation of antibacterial peptide biosynthetic process
GO:0006965positive regulation of biosynthetic process of antibacterial peptides active against Gram-positive bacteria
GO:0007165signal transduction
GO:0009595detection of biotic stimulus
GO:0016045detection of bacterium
GO:0030277maintenance of gastrointestinal epithelium
GO:0031398positive regulation of protein ubiquitination
GO:0032088negative regulation of NF-kappaB transcription factor activity
GO:0032494response to peptidoglycan
GO:0032495response to muramyl dipeptide
GO:0032496response to lipopolysaccharide
GO:0032498detection of muramyl dipeptide
GO:0032689negative regulation of interferon-gamma production
GO:0032695negative regulation of interleukin-12 production
GO:0032701negative regulation of interleukin-18 production
GO:0032703negative regulation of interleukin-2 production
GO:0032720negative regulation of tumor necrosis factor production
GO:0032731positive regulation of interleukin-1 beta production
GO:0032733positive regulation of interleukin-10 production
GO:0032735positive regulation of interleukin-12 production
GO:0032740positive regulation of interleukin-17 production
GO:0032755positive regulation of interleukin-6 production
GO:0032757positive regulation of interleukin-8 production
GO:0032760positive regulation of tumor necrosis factor production
GO:0032874positive regulation of stress-activated MAPK cascade
GO:0034136negative regulation of toll-like receptor 2 signaling pathway
GO:0035419activation of MAPK activity involved in innate immune response
GO:0035556intracellular signal transduction
GO:0042742defense response to bacterium
GO:0042981regulation of apoptotic process
GO:0043123positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0043330response to exogenous dsRNA
GO:0043410positive regulation of MAPK cascade
GO:0043552positive regulation of phosphatidylinositol 3-kinase activity
GO:0044130negative regulation of growth of symbiont in host
GO:0045087innate immune response
GO:0045089positive regulation of innate immune response
GO:0045747positive regulation of Notch signaling pathway
GO:0045944positive regulation of transcription from RNA polymerase II promoter
GO:0046330positive regulation of JNK cascade
GO:0050679positive regulation of epithelial cell proliferation
GO:0050718positive regulation of interleukin-1 beta secretion
GO:0050727regulation of inflammatory response
GO:0050731positive regulation of peptidyl-tyrosine phosphorylation
GO:0050766positive regulation of phagocytosis
GO:0050830defense response to Gram-positive bacterium
GO:0050871positive regulation of B cell activation
GO:0051092positive regulation of NF-kappaB transcription factor activity
GO:0051259protein oligomerization
GO:0051353positive regulation of oxidoreductase activity
GO:0051770positive regulation of nitric-oxide synthase biosynthetic process
GO:0060585positive regulation of prostaglandin-endoperoxide synthase activity
GO:0070374positive regulation of ERK1 and ERK2 cascade
GO:0070423nucleotide-binding oligomerization domain containing signaling pathway
GO:0070431nucleotide-binding oligomerization domain containing 2 signaling pathway
GO:0071224cellular response to peptidoglycan
GO:0071225cellular response to muramyl dipeptide
GO:0071608macrophage inflammatory protein-1 alpha production
GO:0071639positive regulation of monocyte chemotactic protein-1 production
GO:0090022regulation of neutrophil chemotaxis
GO:1900017positive regulation of cytokine production involved in inflammatory response
GO:1901224positive regulation of NIK/NF-kappaB signaling
GO:1904417positive regulation of xenophagy
GO:2000110negative regulation of macrophage apoptotic process
GO:2000363positive regulation of prostaglandin-E synthase activity
Vocabulary: cellular component
TermDefinition
GO:0005737cytoplasm
GO:0005794Golgi apparatus
GO:0005829cytosol
GO:0005856cytoskeleton
GO:0005886plasma membrane
GO:0009986cell surface
GO:0016020membrane
GO:0016323basolateral plasma membrane
GO:0031982vesicle
GO:0043234protein complex
InterPro
Analysis Name: Schmidtea mediteranean smed_20140614 Interproscan
Date Performed: 2020-05-01
IPR TermIPR DescriptionSourceSource TermSource DescriptionAlignment
NoneNo IPR availableGENE3DG3DSA:1.10.238.10coord: 143..267
e-value: 2.4E-10
score: 42.3
NoneNo IPR availablePANTHERPTHR24114:SF30LEUCINE-RICH REPEAT-CONTAINING PROTEIN 74Acoord: 16..229
NoneNo IPR availablePANTHERPTHR24114FAMILY NOT NAMEDcoord: 16..229
NoneNo IPR availableSUPERFAMILYSSF52047RNI-likecoord: 13..122
IPR032675Leucine-rich repeat domain superfamilyGENE3DG3DSA:3.80.10.10coord: 8..124
e-value: 7.8E-12
score: 46.1
IPR002048EF-hand domainPROSITEPS50222EF_HAND_2coord: 155..190
score: 8.209
IPR002048EF-hand domainPROSITEPS50222EF_HAND_2coord: 191..226
score: 6.591
IPR011992EF-hand domain pairSUPERFAMILYSSF47473EF-handcoord: 145..219