Nucleoside diphosphate-linked moiety X motif 19

Overview
NameNucleoside diphosphate-linked moiety X motif 19
Smed IDSMED30011214
Length (bp)1054
Neoblast Clusters

Zeng et. al., 2018



▻ Overview

▻ Neoblast Population

▻ Sub-lethal Irradiated Surviving X1 and X2 Cell Population

 

 

Overview

 

Single cell RNA-seq of pluripotent neoblasts and its early progenies


We isolated X1 neoblasts cells enriched in high piwi-1 expression (Neoblast Population), and profiled ∼7,614 individual cells via scRNA-seq. Unsupervised analyses uncovered 12 distinct classes from 7,088 high-quality cells. We designated these classes Nb1 to Nb12 and ordered them based on high (Nb1) to low (Nb12) piwi-1 expression levels. We further defined groups of genes that best classified the cells parsed into 12 distinct cell clusters to generate a scaled expression heat map of discriminative gene sets for each cluster. Expression of each cluster’s gene signatures was validated using multiplex fluorescence in situ hybridization (FISH) co-stained with piwi-1 and largely confirmed the cell clusters revealed by scRNA-seq.

We also tested sub-lethal irradiation exposure. To profile rare pluripotent stem cells (PSCs) and avoid interference from immediate progenitor cells, we determined a time point after sub-lethal irradiation (7 DPI) with minimal piwi-1+ cells, followed by isolation and single-cell RNA-seq of 1,200 individual cells derived from X1 (Piwi-1 high) and X2 (Piwi-1 low) cell populations (Sub-lethal Irradiated Surviving X1 and X2 Cell Population)



Explore this single cell expression dataset with our NB Cluster Shiny App



 

Neoblast Population

 

t-SNE plot shows two-dimensional representation of global gene expression relationships among all neoblasts (n = 7,088 after filter). Cluster identity was assigned based on the top 10 marker genes of each cluster (Table S2), followed by inspection of RNA in situ hybridization patterns. Neoblast groups, Nb.


Expression of Nucleoside diphosphate-linked moiety X motif 19 (SMED30011214) t-SNE clustered cells

Violin plots show distribution of expression levels for Nucleoside diphosphate-linked moiety X motif 19 (SMED30011214) in cells (dots) of each of the 12 neoblast clusters.

 

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Sub-lethal Irradiated Surviving X1 and X2 Cell Population

 

t-SNE plot of surviving X1 and X2 cells (n = 1,039 after QC filter) after sub-lethal irradiation. Colors indicate unbiased cell classification via graph-based clustering. SL, sub-lethal irradiated cell groups.

Expression of Nucleoside diphosphate-linked moiety X motif 19 (SMED30011214) in the t-SNE clustered sub-lethally irradiated X1 and X2 cells.

Violin plots show distribution of expression levels for Nucleoside diphosphate-linked moiety X motif 19 (SMED30011214) in cells (dots) of each of the 10 clusters of sub-leathally irradiated X1 and X2 cells.

 

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Embryonic Expression

Davies et. al., 2017

Hover the mouse over a column in the graph to view average RPKM values per sample.
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Embryonic Stages: Y: yolk. S2-S8: Stages 2-8. C4: asexual adult. SX: virgin, sexually mature adult.
For further information about sample preparation and analysis for the single animal RNA-Seq experiment, please refer to the Materials and Methods

 

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Anatomical Expression

PAGE et. al., 2020



SMED30011214

has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGE



PAGE Curations: 4

  
Expressed InReference TranscriptGene ModelsPublished TranscriptTranscriptomePublicationSpecimenLifecycleEvidence
whole organismSMED30011214h1SMcG0020622 Contig48452uc_Smed_v2PMID:27612384
Roberts-Galbraith et al., 2016		whole organism asexual adult colorimetric in situ hybridization evidence
whole organismSMED30011214h1SMcG0020622 Contig48452newmark_estsPMID:27612384
Roberts-Galbraith et al., 2016		whole organism asexual adult colorimetric in situ hybridization evidence
reproductive organSMED30011214h1SMcG0020622 Contig48452uc_Smed_v2PMID:28434803
Rouhana et al., 2017		whole organism adult hermaphrodite RNA-sequencing evidence
reproductive organSMED30011214h1SMcG0020622 Contig48452newmark_estsPMID:28434803
Rouhana et al., 2017		whole organism adult hermaphrodite RNA-sequencing evidence
Note: Hover over icons to view figure legend
Homology
[Close]
BLAST of Nucleoside diphosphate-linked moiety X motif 19 vs. Ensembl Human
Match: NUDT19 (nudix hydrolase 19 [Source:HGNC Symbol;Acc:HGNC:32036])

HSP 1 Score: 104.375 bits (259), Expect = 1.511e-24
Identity = 77/274 (28.10%), Postives = 119/274 (43.43%), Query Frame = 2 
Query:  116 FKVLMLKRISSSQSFAGKMVFPGGVLDKCDFNDEWNKIFNKKYNLPQLNSLKCDKEMVIYKDSKDLSKIK-------PE-IFYRICAIRETFEETGILIANDKYHKPVLHNKILM---KDISENHWQQNVLKDGNLFIELFKSYELVPDLFSLYEWSEWITPSI--FNRRFHTAFYIFISDSSVETNINEDESCSISWVIPEEIVHEPSSYKE--LAPPQFLELLAMNSLFSIRDIQVAALRRQQKSGGISNMTKVISLS-NGKLIVLPGDSRY 889
            F++L+L+R        G  VF GGVLD  D + +W  +F   +  P+            +    D    K       PE + +RICA+RE FEE G+L+   +   P       +          W+  V +D   F+ L    +  PD+++L+ WS W+TP +    RRF TAF++           +  E     W  P E   E    KE  L PPQF E+  + +  S+ D+    L R  +  G+     +I L+ +G + +LPGD  Y
Sbjct:   42 FRLLLLQRSPHQGFMPGAHVFSGGVLDAADRSADWLGLFAPHHGPPRFGLGPAPFSRTAFPSLPDTDDHKTDNTGTLPEDVAFRICAVREAFEEAGVLLLRPRTSPPGPAPGPGLALEPPPGLASWRDRVRQDPRHFLRLCAHLDCTPDIWALHNWSAWLTPFLRGTTRRFDTAFFLCCLREPPPVYPDLAEVVGYQWSSPSEAT-ESFLSKEIWLPPPQFYEVRRLANFASLSDLHKFCLGRALE--GLERWLPIILLTADGMVHLLPGDELY 312
[Close]
BLAST of Nucleoside diphosphate-linked moiety X motif 19 vs. Ensembl Celegans
Match: ndx-7 (Putative nudix hydrolase 7 [Source:UniProtKB/Swiss-Prot;Acc:P91148])

HSP 1 Score: 77.411 bits (189), Expect = 5.931e-16
Identity = 61/215 (28.37%), Postives = 98/215 (45.58%), Query Frame = 2 
Query:  119 KVLMLKRISSSQSFAGKMVFPGGVLDKCDFNDEWNKIFNKKYNLPQLNSLKCDKEMVIYKDSKDLSKIKPEIFYRICAIRETFEETGILIANDKYHKPVLHNKILMKDISENHWQQNVLKDGNLFIELFKSYELVPDLFSLYEWSEWITPSIFNRRFHTAFYIFISDSSVETNINEDESCSISWVIPEEIVHEPSSYK-ELAPPQFLELLAMNSL 760
            +VLMLKR ++++     MVFPGGV+DK D                                    +K+  E  +RI A+RE FEE+G+L   + +      N   M  +     + +++ D + F +L  S  +  D  +L EW  +ITP+ + RRF T FY+ + D     ++   E    +W+ P+E V E  + K  L PPQ  EL  ++ +
Sbjct:   25 RVLMLKRGTTAKFMPNTMVFPGGVVDKTD------------------------------------AKLGDE--FRIAAVRELFEESGVLSTKNGWQTSA--NNPDMTSL-----KADIVNDTSKFEQL--SGTICAD--NLIEWDTFITPANYPRRFLTKFYLMLVDDEPAIDLCTSEMSEYNWIEPKECVDEAYAGKYALPPPQVYELTRLSQV 190
[Close]
BLAST of Nucleoside diphosphate-linked moiety X motif 19 vs. Ensembl Fly
Match: CG10194 (gene:FBgn0032790 transcript:FBtr0081285)

HSP 1 Score: 136.732 bits (343), Expect = 6.853e-37
Identity = 96/282 (34.04%), Postives = 142/282 (50.35%), Query Frame = 2 
Query:  113 DFKVLMLKRISSSQSFAGKMVFPGGVLDKCDFNDEWNKIFNK-KYNLPQLNSLKCDK--EMVIYKDSKDLSKIKPEIFYRICAIRETFEETGILIAND-KYHKPVLHNKILMKDISENHWQQNVLKDGNLFIELFKSYELVPDLFSLYEWSEWITPSIFNRRFHTAFYIFISDSSVETNINEDESCSISWVIPEEIVHEPSSYKE--LAPPQFLELLAMNSLFSIRDIQVAALRRQQKSGGISNMTKVI-SLSNGKLIVLPGDSRYPAD-----HKDEIDLS 922
            D+  L+L R   S       VFPGGV D  D +  W + F + +++  +L ++   K     I+    D   + P +  R+ AIRETFEE GIL+  D K                  HWQ  V  + + F+EL K  +++PD++SL+EWS W TPS F +RF TAF++   +     +I  +E    +W  P + + + S  KE  L PPQF EL    +  S+ +++  A  R+ K  GI  +  V+   +NG + +LPGD  YPAD      K EIDLS
Sbjct:   29 DYNALLLTRTQKSTFMPESSVFPGGVCDASDSSPAWLEHFQRNEFSAAKLRNVGHVKGPRPDIFHTKADKKSLDPSLALRLTAIRETFEELGILLCRDSKSLTSTSDYGAFYDQFDRAHWQHIVHNNASQFLELCKQLDVLPDVWSLHEWSVWRTPSTFKKRFETAFFMTALEQEPRVHIEPNEVKDSAWRSPLDYL-QASLRKELWLPPPQFYELSRCLNFSSLDNLRQFAAEREVK--GIQLIHPVVHKCTNGLVHLLPGDDAYPADPDASNEKIEIDLS 307
[Close]
BLAST of Nucleoside diphosphate-linked moiety X motif 19 vs. Ensembl Fly
Match: CG18094 (gene:FBgn0032791 transcript:FBtr0331324)

HSP 1 Score: 107.457 bits (267), Expect = 5.022e-26
Identity = 92/315 (29.21%), Postives = 151/315 (47.94%), Query Frame = 2 
Query:  113 DFKVLMLKRISSSQSFAGKMVFPGGVLDKC-DFNDEWNKIFNKKYNLPQLNSLKCDKEMVIYKDSKDLSK---------IKPEIFYRICAIRETFEETGILIAND-----KYHKPVLHNKILMKDISEN-HWQQNVLKDGNLFIELFKSYELVPDLFSLYEWSEWITPSIFNRRFHTAFYIFISDS---SVETNINEDESCSISWVIPEEIVHEPSSYKELAPPQFLELLAMNSLFSIRDIQVAALRRQQKSGGISNMTKVI--SLSNGKLIVLPGDSRYPADH---KDEIDLSHFSFIDL-EKDENLNRFFVSD 982
            D+++L++KR   +       VFPGGV D   D + +W   F K + +        D+++ + + ++D  +         I  +I  R+ A+RETFEE GILI  +     K+     H + ++ + SE+  WQ  V  D + F+ELF+ Y+++P+++SL EWS W T +  NR++ T +YI + D    +++  +   E  S  W+ P E     SS K +    F+ L  +  L +    Q      +Q+S   S M + +     +    VLPGD  YP +       I LS  S  DL  K +  NR+ V D
Sbjct:   27 DYRLLLIKRTEKTSYALNHCVFPGGVFDPIEDQSAKWITFF-KSFGV-------TDEQLKMCRHNQDSPRPEFLSGGDHISRDIALRLTALRETFEEVGILICTEQDDIQKWDSKSGHPRTVLLESSEHFEWQHRVHNDASQFLELFRHYKVIPNIWSLQEWSIWRTAATANRKYDTVYYITMLDKYTRNIKLLLEPHEVASAHWLSPIEAW--SSSQKAIIWLPFMLLYDIARLMNFYSFQELLNFSRQRSCNGSTMVQPVYYRCDDCMFGVLPGDELYPKEPGACTQTIILSG-SVDDLHRKSKQYNRYIVYD 330
[Close]
BLAST of Nucleoside diphosphate-linked moiety X motif 19 vs. Ensembl Fly
Match: CG18094 (gene:FBgn0032791 transcript:FBtr0081243)

HSP 1 Score: 107.457 bits (267), Expect = 5.022e-26
Identity = 92/315 (29.21%), Postives = 151/315 (47.94%), Query Frame = 2 
Query:  113 DFKVLMLKRISSSQSFAGKMVFPGGVLDKC-DFNDEWNKIFNKKYNLPQLNSLKCDKEMVIYKDSKDLSK---------IKPEIFYRICAIRETFEETGILIAND-----KYHKPVLHNKILMKDISEN-HWQQNVLKDGNLFIELFKSYELVPDLFSLYEWSEWITPSIFNRRFHTAFYIFISDS---SVETNINEDESCSISWVIPEEIVHEPSSYKELAPPQFLELLAMNSLFSIRDIQVAALRRQQKSGGISNMTKVI--SLSNGKLIVLPGDSRYPADH---KDEIDLSHFSFIDL-EKDENLNRFFVSD 982
            D+++L++KR   +       VFPGGV D   D + +W   F K + +        D+++ + + ++D  +         I  +I  R+ A+RETFEE GILI  +     K+     H + ++ + SE+  WQ  V  D + F+ELF+ Y+++P+++SL EWS W T +  NR++ T +YI + D    +++  +   E  S  W+ P E     SS K +    F+ L  +  L +    Q      +Q+S   S M + +     +    VLPGD  YP +       I LS  S  DL  K +  NR+ V D
Sbjct:   27 DYRLLLIKRTEKTSYALNHCVFPGGVFDPIEDQSAKWITFF-KSFGV-------TDEQLKMCRHNQDSPRPEFLSGGDHISRDIALRLTALRETFEEVGILICTEQDDIQKWDSKSGHPRTVLLESSEHFEWQHRVHNDASQFLELFRHYKVIPNIWSLQEWSIWRTAATANRKYDTVYYITMLDKYTRNIKLLLEPHEVASAHWLSPIEAW--SSSQKAIIWLPFMLLYDIARLMNFYSFQELLNFSRQRSCNGSTMVQPVYYRCDDCMFGVLPGDELYPKEPGACTQTIILSG-SVDDLHRKSKQYNRYIVYD 330
[Close]
BLAST of Nucleoside diphosphate-linked moiety X motif 19 vs. Ensembl Fly
Match: CG10195 (gene:FBgn0032787 transcript:FBtr0332318)

HSP 1 Score: 93.2041 bits (230), Expect = 4.823e-21
Identity = 88/331 (26.59%), Postives = 145/331 (43.81%), Query Frame = 2 
Query:  113 DFKVLMLKRISSSQSFAGKMVFPGGVLDK-CDFNDEWNKIFNKKYNLPQ-----LNSLKCDKEMVI-----------YKDSKDLSKIKPEIFYRICAIRETFEETGILIANDKYHKPVLHNKILMKDISENHWQQNVLKDGNLFIELFKSYELVPDLFSLYEWSEWITPSIFNRRFHTAFYIFISDSSVETNINEDESCSISWVIPEEIVHEPS-SYKELAPPQFLELLAMNSLFSIRDIQVAALRRQQKSGGISNMTKVISLS-NGKLI-VLPGDSRY-PADHKDEIDLSH--FSFIDLE-----KDENLNRFFVSDGLFNFRYNLNGSN 1021
            D+KVLMLKR  ++     + VFPGG+LD   D +  W   + +++ +PQ     L  ++ D+  ++           +K S+  ++   EI  R+ A+RE FEE G+L+   +                   WQ+ V      F+ L +   +VPDL++L+EWS W +P    +   T F++   D   E      E     W+ P E++           PPQ  EL  +  + + + +   A++R   SG  + M   I  +  G ++ VLPGD  Y P  H     L H   SF   E     + ++L+R+    G+ N   N+   N
Sbjct:   28 DYKVLMLKRSDATAIALNQTVFPGGLLDSGADESVAWLH-YLEEFGVPQEALRRLVLIREDRPAILAPQGTGCYDRFFKRSRIWAR---EITLRLTAVRECFEEVGLLLCRSRSQLDFGAVTCAQAVPDLESWQRRVHNKPAEFLTLCRELNVVPDLWALHEWSAWASPGFIRKGHETVFFMAFVDKQPELLEEPSEVKETLWLTPVELLRLADLGNVWFMPPQVYELSRLMGIKAYQSLLEFAIKR---SGLGTTMFLPIGYNCQGSMVFVLPGDDFYVPEPH-----LVHEIISFPGSEEEFRARSKHLHRYTYGPGVRNLELNIAPPN 346
[Close]
BLAST of Nucleoside diphosphate-linked moiety X motif 19 vs. Ensembl Fly
Match: CG10195 (gene:FBgn0032787 transcript:FBtr0302930)

HSP 1 Score: 93.2041 bits (230), Expect = 4.823e-21
Identity = 88/331 (26.59%), Postives = 145/331 (43.81%), Query Frame = 2 
Query:  113 DFKVLMLKRISSSQSFAGKMVFPGGVLDK-CDFNDEWNKIFNKKYNLPQ-----LNSLKCDKEMVI-----------YKDSKDLSKIKPEIFYRICAIRETFEETGILIANDKYHKPVLHNKILMKDISENHWQQNVLKDGNLFIELFKSYELVPDLFSLYEWSEWITPSIFNRRFHTAFYIFISDSSVETNINEDESCSISWVIPEEIVHEPS-SYKELAPPQFLELLAMNSLFSIRDIQVAALRRQQKSGGISNMTKVISLS-NGKLI-VLPGDSRY-PADHKDEIDLSH--FSFIDLE-----KDENLNRFFVSDGLFNFRYNLNGSN 1021
            D+KVLMLKR  ++     + VFPGG+LD   D +  W   + +++ +PQ     L  ++ D+  ++           +K S+  ++   EI  R+ A+RE FEE G+L+   +                   WQ+ V      F+ L +   +VPDL++L+EWS W +P    +   T F++   D   E      E     W+ P E++           PPQ  EL  +  + + + +   A++R   SG  + M   I  +  G ++ VLPGD  Y P  H     L H   SF   E     + ++L+R+    G+ N   N+   N
Sbjct:   28 DYKVLMLKRSDATAIALNQTVFPGGLLDSGADESVAWLH-YLEEFGVPQEALRRLVLIREDRPAILAPQGTGCYDRFFKRSRIWAR---EITLRLTAVRECFEEVGLLLCRSRSQLDFGAVTCAQAVPDLESWQRRVHNKPAEFLTLCRELNVVPDLWALHEWSAWASPGFIRKGHETVFFMAFVDKQPELLEEPSEVKETLWLTPVELLRLADLGNVWFMPPQVYELSRLMGIKAYQSLLEFAIKR---SGLGTTMFLPIGYNCQGSMVFVLPGDDFYVPEPH-----LVHEIISFPGSEEEFRARSKHLHRYTYGPGVRNLELNIAPPN 346
[Close]
BLAST of Nucleoside diphosphate-linked moiety X motif 19 vs. Ensembl Zebrafish
Match: nudt19 (nudix (nucleoside diphosphate linked moiety X)-type motif 19 [Source:ZFIN;Acc:ZDB-GENE-081022-80])

HSP 1 Score: 129.413 bits (324), Expect = 1.188e-33
Identity = 87/285 (30.53%), Postives = 142/285 (49.82%), Query Frame = 2 
Query:  113 DFKVLMLKRISSSQSFAGKMVFPGGVLDKCDFNDEWNKIFN-----KKYNLPQLNSLKCDKEMVIYKDSKDL-SKIKPEIFYRICAIRETFEETGILIANDKYHKPVLHNKILMKDISENH------------WQQNVLKDGNLFIELFKSYELVPDLFSLYEWSEWITP-SIFN--RRFHTAFYIFISDSSVETNINEDESCSISWVIPEEIVHEPSSYKE----LAPPQFLELLAMNSLFSIRDIQVAALRRQQKSGGISNMTKVISL-SNGKLIVLPGDSRY 889
            D++VL+LKR  +S       VFPGG++D  DF+ EW ++FN       Y +  +      +  +   D   L S I  ++ +RICA+RETFEE+G+L+A  K    V   + L    S               W+  V+ D   FI++ +  + +P++++L+EW  W+TP  ++   RR+ TAFYI     +  T  ++ E     W  P +++    SYK     +APPQ+ ++  M    ++RD+   A   Q+ S G      V  L S+G + +LPGD+ Y
Sbjct:   46 DYEVLLLKRSRNSGFMPNAYVFPGGLVDASDFSSEWQELFNPFTKAPNYGVKVVKQSPETRPPIFATDRSQLGSPIPGDVAFRICAVRETFEESGVLLALPKDEYSVTRTRSLDTQPSLTRLSGQWGTEVLSKWRSRVIGDPANFIKMCRELQCLPNIWALHEWGNWLTPIGLYGKQRRYDTAFYICCLQETPHTLHDDKEIVHFKWSTPLDVLR---SYKSRDIWIAPPQYYDIGRMCRFPALRDLHHFAW--QRSSEGCEQWLPVHMLTSDGFVSLLPGDTMY 325
[Close]
BLAST of Nucleoside diphosphate-linked moiety X motif 19 vs. Ensembl Zebrafish
Match: nudt19 (nudix (nucleoside diphosphate linked moiety X)-type motif 19 [Source:ZFIN;Acc:ZDB-GENE-081022-80])

HSP 1 Score: 121.324 bits (303), Expect = 3.787e-31
Identity = 76/258 (29.46%), Postives = 128/258 (49.61%), Query Frame = 2 
Query:  113 DFKVLMLKRISSSQSFAGKMVFPGGVLDKCDFNDEWNKIFN-----KKYNLPQLNSLKCDKEMVIYKDSKDL-SKIKPEIFYRICAIRETFEETGILIANDKYHKPVLHNKILMKDISENH------------WQQNVLKDGNLFIELFKSYELVPDLFSLYEWSEWITP-SIFN--RRFHTAFYIFISDSSVETNINEDESCSISWVIPEEIVHEPSSYKE----LAPPQFLELLAMNSLFSIRDIQVAALRRQQKS 811
            D++VL+LKR  +S       VFPGG++D  DF+ EW ++FN       Y +  +      +  +   D   L S I  ++ +RICA+RETFEE+G+L+A  K    V   + L    S               W+  V+ D   FI++ +  + +P++++L+EW  W+TP  ++   RR+ TAFYI     +  T  ++ E     W  P +++    SYK     +APPQ+ ++  M    ++RD+   A +R  + 
Sbjct:   46 DYEVLLLKRSRNSGFMPNAYVFPGGLVDASDFSSEWQELFNPFTKAPNYGVKVVKQSPETRPPIFATDRSQLGSPIPGDVAFRICAVRETFEESGVLLALPKDEYSVTRTRSLDTQPSLTRLSGQWGTEVLSKWRSRVIGDPANFIKMCRELQCLPNIWALHEWGNWLTPIGLYGKQRRYDTAFYICCLQETPHTLHDDKEIVHFKWSTPLDVLR---SYKSRDIWIAPPQYYDIGRMCRFPALRDLHHFAWQRSSEG 300
[Close]
BLAST of Nucleoside diphosphate-linked moiety X motif 19 vs. Ensembl Xenopus
Match: acss3 (acyl-CoA synthetase short chain family member 3 [Source:Xenbase;Acc:XB-GENE-6035224])

HSP 1 Score: 126.331 bits (316), Expect = 1.779e-32
Identity = 90/316 (28.48%), Postives = 154/316 (48.73%), Query Frame = 2 
Query:  113 DFKVLMLKRISSSQSFAGKMVFPGGVLDKCDFNDEWNKIFNK-----KYNLPQLNSLKCDKEMVIYKDSKDLSKIKPEIFYRICAIRETFEETGI-LIANDKYHKPVLHNKILMKDISE---NHWQQNVLKDGNLFIELFKSYELVPDLFSLYEWSEWITP----SIFNRRFHTAFYIFISDSSVETNINEDESCSISWVIPEEIVHEPSSYK-ELAPPQFLELLAMNSLFSIRDIQVAALRRQQKSGGISNMTKVISLSNGKLIVLPGDSRYPADHKDEIDLSHFSFIDLEKDENLNRFFVSDGLFNFRYNLNGS 1018
            D++VL+LKR   S       VFPGG ++  DF+ +W K+F++      + L  +        M     SK  S I  E+  RICAIRETFEE+GI L+  + ++     N I + D  +   + W+Q V ++ + FI++ +    +P++++L EWS W+TP     + +RRF TAF+I   ++    + ++ E  S  W  P E + +   +K  + PPQF E+  +     I ++    + R  + G    M  +    +G +  LPGD  YP    +E DL+      +  +E +       G F+    ++G+
Sbjct:   43 DYEVLLLKRSQKSGFMPNAFVFPGGNVEPSDFSSDWIKVFSRYEQKPNFGLGLVKQHDNRSPMFTTDRSKFGSLIPGEVATRICAIRETFEESGILLVVPENFNSEDNQNLIDITDHDKEEISKWRQEVQRNPSQFIQMCRMMRCMPNIWALKEWSNWLTPVFSQGLKSRRFDTAFFICCLNAKPAVSDDKKEVTSFKWWTPVEALEDYKCHKIWIPPPQFYEISRLCHFAPINELHKFIISRSLE-GCEQWMPVIAQCEDGIVHTLPGDDLYP----EEPDLTGEKQTVVCSNETIQNLVQKGGCFHRVVVIDGT 353
[Close]
BLAST of Nucleoside diphosphate-linked moiety X motif 19 vs. Ensembl Mouse
Match: Nudt19 (nudix (nucleoside diphosphate linked moiety X)-type motif 19 [Source:MGI Symbol;Acc:MGI:94203])

HSP 1 Score: 112.849 bits (281), Expect = 7.727e-28
Identity = 78/274 (28.47%), Postives = 126/274 (45.99%), Query Frame = 2 
Query:  116 FKVLMLKRISSSQSFAGKMVFPGGVLDKCDFNDEWNKIFNKKYNLPQLN----SLKCDKEMVIYKDSKDLSKIKPEIFYRICAIRETFEETGILIANDKYHKPVLH--NKILMKDISENHWQQNVLKDGNLFIELFKSYELVPDLFSLYEWSEWITPSIFN-RRFHTAFYIFISDSSVETNINEDESCSISWVIPEEIVHEPSSYKE--LAPPQFLELLAMNSLFSIRDIQVAALRR---QQKSGGISNMTKVISL-SNGKLIVLPGDSRYPAD 898
            F++L+L+R  + +   G  VFPGGVLD  D + +W ++F  ++  P+        +      +     D + +  ++  RICAIRE FEE G+L+   +   P     ++ L        W+  V  D   F++L    +  PD+++L++W  W+TP     RRF T F++           +  E     W+ P E   E    KE  LAPPQF E+  + +  S+     +AL R    + S        +I L S+G + +LPGD  Y  D
Sbjct:   27 FRLLLLQRAQNQRFLPGAHVFPGGVLDAADSSPDWVRLFAPRHTPPRFGLGPEPPRQPPFPGLSHGDADPAALPDDVALRICAIREAFEEAGVLLLRPRDAAPASQEPSQALSPPAGLAEWRSRVRSDPRCFLQLCAHLDCTPDIWALHDWGGWLTPYGRTIRRFDTTFFLCCLRDIPRVEPDVAEVVGYQWLSPSEAT-ECFLSKEIWLAPPQFYEMRRLENFASL-----SALYRFCSDRPSEVPEKWLPIILLTSDGTIHLLPGDELYVKD 294
[Close]
BLAST of Nucleoside diphosphate-linked moiety X motif 19 vs. UniProt/SwissProt
Match: sp|Q5PQ50|NUD19_XENLA (Nucleoside diphosphate-linked moiety X motif 19 OS=Xenopus laevis OX=8355 GN=nudt19 PE=2 SV=1)

HSP 1 Score: 129.798 bits (325), Expect = 3.679e-33
Identity = 92/311 (29.58%), Postives = 154/311 (49.52%), Query Frame = 2 
Query:  113 DFKVLMLKRISSSQSFAGKMVFPGGVLDKCDFNDEWNKIFNK-----KYNLPQLNSLKCDKEMVIYKDSKDLSKIKPEIFYRICAIRETFEETGI-LIANDKYHKPVLHNKILMKDISE---NHWQQNVLKDGNLFIELFKSYELVPDLFSLYEWSEWITP----SIFNRRFHTAFYIFISDSSVETNINEDESCSISWVIPEEIVHEPSSYK-ELAPPQFLELLAMNSLFSIRDIQVAALRRQQKSGGISNMTKVISLSNGKLIVLPGDSRYPAD-----HKDEIDLSHFSFIDL-EKDENLNRFFVSDG 985
            D++VL+LKR   S       VFPGG ++  DF+ +W K+F++      + L  +  L     M     SK  S I  E+  RICAIRETFEE+GI L+  + ++     + + + D  +   + W++ V ++ + FI++ K    +P++++L EWS W+TP     + +RRF TAF+I   ++    + +  E  S  W  P E + +  S+K  + PPQF EL  +     I ++    + R  + G    M  +    +G +  LPGD  YP D      K  +  S+ +  +L +K    +R  + DG
Sbjct:   43 DYEVLLLKRSQKSGFMPNAFVFPGGNIESSDFSSDWIKVFSRYEQKPNFGLGLVKQLDNRSPMFTADSSKFGSLIPGEVATRICAIRETFEESGILLVVPENFNSEDNQHLVEVTDQDKEKLSKWREEVQRNPSQFIQMCKEMRCMPNIWALKEWSNWLTPVISQGVKSRRFDTAFFICCLNAKPAVSDDNKEVTSFKWWTPTEALEDYKSHKIWIPPPQFYELSRLCHFAPINELHKFIVNRSLE-GCERWMPVIAQCEDGIVHTLPGDDLYPEDPDLTGEKQTVVCSNETIENLIQKGGRFHRLVLIDG 352
[Close]
BLAST of Nucleoside diphosphate-linked moiety X motif 19 vs. UniProt/SwissProt
Match: sp|Q7M0H3|NUD19_MUSCR (Nucleoside diphosphate-linked moiety X motif 19 OS=Mus caroli OX=10089 GN=Nudt19 PE=2 SV=1)

HSP 1 Score: 120.553 bits (301), Expect = 7.039e-30
Identity = 78/274 (28.47%), Postives = 129/274 (47.08%), Query Frame = 2 
Query:  116 FKVLMLKRISSSQSFAGKMVFPGGVLDKCDFNDEWNKIFNKKYNLPQLN----SLKCDKEMVIYKDSKDLSKIKPEIFYRICAIRETFEETGILIANDKYHKPVLH--NKILMKDISENHWQQNVLKDGNLFIELFKSYELVPDLFSLYEWSEWITP-SIFNRRFHTAFYIFISDSSVETNINEDESCSISWVIPEEIVHEPSSYKE--LAPPQFLELLAMNSLFSIRDIQVAALRR----QQKSGGISNMTKVISLSNGKLIVLPGDSRYPAD 898
            F++L+L+R  + +   G  VFPGGVLD  D + +W ++F  ++  P+        +      +     D + +  ++  RICAIRETFEE G+L+   +   P     ++ L        W+  V  D   F++L    +  PD+++L++W  W+TP     RRF T F +     +     +  E     W+ P E   E    KE  LAPPQF E+  +++  S+     +AL R    +   GG   +  ++  S+G + +LPGD  Y  D
Sbjct:   27 FRLLLLQRSQNQRFIPGAHVFPGGVLDAADSSPDWVRLFAPRHTPPRFGLGPEPPRQPPFPGLSHGDADPAALPDDVALRICAIRETFEEAGVLLLRPRDADPASQEPSQALSPPAGLAEWRSRVRSDPRCFLQLCAHLDCTPDIWALHDWGGWLTPYGRITRRFDTTFLLCCLRDTPRVEPDLAEVVGYQWLSPSEAT-ECFLSKEIWLAPPQFYEIRRLDNFASL-----SALYRFCSDRPLEGGEKWLPIILLTSDGTIHLLPGDELYVKD 294
[Close]
BLAST of Nucleoside diphosphate-linked moiety X motif 19 vs. UniProt/SwissProt
Match: sp|Q5ZL13|NUD19_CHICK (Nucleoside diphosphate-linked moiety X motif 19 OS=Gallus gallus OX=9031 GN=NUDT19 PE=2 SV=1)

HSP 1 Score: 118.627 bits (296), Expect = 6.039e-29
Identity = 84/281 (29.89%), Postives = 137/281 (48.75%), Query Frame = 2 
Query:  113 DFKVLMLKRISSSQSFAGKMVFPGGVLDKCDFNDEWNKIFNKKYNLPQLNSLK-----CDKEMVIYKDSKDLSKIKP-EIFYRICAIRETFEETGILI-------ANDKYHKPVLHNKILMKDISENHWQQNVLKDGNLFIELFKSYELVPDLFSLYEWSEWITP----SIFNRRFHTAFYIFISDS-SVETNINEDESCSISWVIPEEIVHEPSSYK-ELAPPQFLELLAMNSLFSIRDIQVAALRRQQKSGGISNMTKVISLSNGKLIVLPGDSRYPAD 898
            D+++L L+R S S       VFPGG+++  DF+ EW ++         L +++       +  +   D + L    P E+ +RICAIRETFEE GIL+              P L  + L+       W++ V +D   F++L +    VPD+++L EWS W+TP        RR+ TAFY+   ++    T+ +  E  +  W  P E +    S +  LAPPQF EL  + +  S+ D+   +  R  + G    +   ++ ++G + +LPGD  YP D
Sbjct:   33 DYELLFLQRSSRSGFMPSAHVFPGGLVEAADFSAEWLRLLPAAPRC-GLGAVRPPPPGGSRAPLFATDRQPLGSPLPGEVAFRICAIRETFEEAGILLLAPGGRPREGSGPAPSLPAEQLLPAAELGEWRRRVQEDPACFLQLCQRLGRVPDIWALQEWSNWLTPVGRAGRGGRRYDTAFYLCCLETRPPHTSQDNQEIAAFLWSSPPEAIERFKSQEIWLAPPQFYELCRLCNFSSLNDLHKFSSDRALE-GCERWLPVTLTAADGFIQLLPGDELYPED 311
[Close]
BLAST of Nucleoside diphosphate-linked moiety X motif 19 vs. UniProt/SwissProt
Match: sp|P11930|NUD19_MOUSE (Nucleoside diphosphate-linked moiety X motif 19 OS=Mus musculus OX=10090 GN=Nudt19 PE=1 SV=2)

HSP 1 Score: 112.849 bits (281), Expect = 5.405e-27
Identity = 78/274 (28.47%), Postives = 126/274 (45.99%), Query Frame = 2 
Query:  116 FKVLMLKRISSSQSFAGKMVFPGGVLDKCDFNDEWNKIFNKKYNLPQLN----SLKCDKEMVIYKDSKDLSKIKPEIFYRICAIRETFEETGILIANDKYHKPVLH--NKILMKDISENHWQQNVLKDGNLFIELFKSYELVPDLFSLYEWSEWITPSIFN-RRFHTAFYIFISDSSVETNINEDESCSISWVIPEEIVHEPSSYKE--LAPPQFLELLAMNSLFSIRDIQVAALRR---QQKSGGISNMTKVISL-SNGKLIVLPGDSRYPAD 898
            F++L+L+R  + +   G  VFPGGVLD  D + +W ++F  ++  P+        +      +     D + +  ++  RICAIRE FEE G+L+   +   P     ++ L        W+  V  D   F++L    +  PD+++L++W  W+TP     RRF T F++           +  E     W+ P E   E    KE  LAPPQF E+  + +  S+     +AL R    + S        +I L S+G + +LPGD  Y  D
Sbjct:   27 FRLLLLQRAQNQRFLPGAHVFPGGVLDAADSSPDWVRLFAPRHTPPRFGLGPEPPRQPPFPGLSHGDADPAALPDDVALRICAIREAFEEAGVLLLRPRDAAPASQEPSQALSPPAGLAEWRSRVRSDPRCFLQLCAHLDCTPDIWALHDWGGWLTPYGRTIRRFDTTFFLCCLRDIPRVEPDVAEVVGYQWLSPSEAT-ECFLSKEIWLAPPQFYEMRRLENFASL-----SALYRFCSDRPSEVPEKWLPIILLTSDGTIHLLPGDELYVKD 294
[Close]
BLAST of Nucleoside diphosphate-linked moiety X motif 19 vs. UniProt/SwissProt
Match: sp|Q7M0H4|NUD19_MUSSA (Nucleoside diphosphate-linked moiety X motif 19 OS=Mus saxicola OX=10094 GN=Nudt19 PE=2 SV=1)

HSP 1 Score: 112.079 bits (279), Expect = 9.551e-27
Identity = 77/274 (28.10%), Postives = 127/274 (46.35%), Query Frame = 2 
Query:  116 FKVLMLKRISSSQSFAGKMVFPGGVLDKCDFNDEWNKIFNKKYNLPQLN----SLKCDKEMVIYKDSKDLSKIKPEIFYRICAIRETFEETGILIANDKYHKPVLH--NKILMKDISENHWQQNVLKDGNLFIELFKSYELVPDLFSLYEWSEWITPSIFN-RRFHTAFYIFISDSSVETNINEDESCSISWVIPEEIVHEPSSYKE--LAPPQFLELLAMNSLFSIRDIQVAALRRQQKSGGISNMTK----VISLSNGKLIVLPGDSRYPAD 898
            F++L+L+R  + +   G  VFPGGVLD  D + +W ++F  ++  P+        +      +     D + +  ++  RICAIRETFEE G+L+   +   P     ++ L        W+  V  D   F++L    +  PD+++L++W  W+TP   + RRF T F +     +     +  E     W+ P E   E    KE  LAPPQF E+  + +  S+     +AL R      +    K    ++  S+G + +LPGD  Y  D
Sbjct:   27 FRLLLLQRAQNQRFLPGAHVFPGGVLDAADSSPDWVRLFAPRHTPPRFGLGPEPPRQPPFPGLSHGDADPAALPDDVALRICAIRETFEEAGVLLLRPR-DAPASQEPSQALSPPAGLAEWRSRVRSDPRCFLQLCAHLDCTPDIWALHDWGGWLTPYGRSLRRFDTTFLLCCLRDTPRVEPDLAEVVGYQWLSPSEAT-ECFLSKEIWLAPPQFYEMRRLENFASL-----SALYRFCSDRPLEVAQKWLPIILVTSDGSVHLLPGDELYVKD 293
[Close]
BLAST of Nucleoside diphosphate-linked moiety X motif 19 vs. TrEMBL
Match: A0A2G8JYJ7 (Putative nucleoside diphosphate-linked moiety X motif 19, mitochondrial-like OS=Stichopus japonicus OX=307972 GN=BSL78_22281 PE=4 SV=1)

HSP 1 Score: 147.902 bits (372), Expect = 2.198e-37
Identity = 98/320 (30.63%), Postives = 168/320 (52.50%), Query Frame = 2 
Query:  113 DFKVLMLKRISSSQSFAGKMVFPGGVLDKCDFNDEWNKIFNK----KYNLPQLNSLKCDKEMVIYKDSKDLSKIKPEIFYRICAIRETFEETGILIAND----KYHKPVLHNKILMKDIS----------ENHWQQNVLKDGNLFIELFKSYELVPDLFSLYEWSEWITPSIFNRRFHTAFYIFISDSSVETNINEDESCSISWVIPEEIVHEPSSYK-ELAPPQFLELLAMNSLFSIRDIQVAALRRQQKSGGISNMTKVISLSNGKLIVLPGDSRYPADHKDEIDLSHFSFIDLEKDENLNRF-FVSDGLFNFRYNLN 1012
            D+++L+L+R S S+SFAG  VFPGGV+D  DF+ +W ++F++    + +    + +K           +D   +  ++ +RICAIRETFEE+GIL+A +    KY    + NK  +   S          +N W++ V  D   F+E+    ++ P+++SL+E S  +TP I +RR+ T FYI   +      +++ E   + W+ P E + +   ++ +L  PQ  E   +    +I +IQ  A+  Q   G ++ +   I L +  L VLPGD  YP + K  + +      +L++ +NLNR+ + SDG F    N+ 
Sbjct:   43 DYRILLLQRDSQSRSFAGASVFPGGVVDPADFSPKWFQLFSRLGIWRGDDFGWSHMKGKPRAGPIAAQRDEGLLPNDVAFRICAIRETFEESGILLAVNEADVKYSISRMKNKQFVPSTSYCDSMNVRAYDNEWRRRVHDDAYQFLEMCMYLDVYPNIWSLFELSTVLTPPITSRRYDTIFYICSLEKEPYAEVDQKEMIDLQWLTPAEAIRKHCRHEIQLPMPQISECARLLDYRNISEIQGYAV-GQMDQGMLAEVPAPIKLKDAFLRVLPGDDCYPGEVK-YLQMEESEEENLKRCKNLNRYTYRSDGHFTLICNVT 360
[Close]
BLAST of Nucleoside diphosphate-linked moiety X motif 19 vs. TrEMBL
Match: A0A2B4RLM4 (Nucleoside diphosphate-linked moiety X motif 19, mitochondrial OS=Stylophora pistillata OX=50429 GN=nudt19 PE=4 SV=1)

HSP 1 Score: 145.976 bits (367), Expect = 1.001e-36
Identity = 104/342 (30.41%), Postives = 171/342 (50.00%), Query Frame = 2 
Query:   35 SFSKMSVIKSASLXXXXXXXXXXXXXDFKVLMLKRISSSQSFAGKMVFPGGVLDKCDFNDEWNKIFNKKY-----NLPQLNSLKCDKEMVIYKDSKDLSKIKPEIFYRICAIRETFEETGILI----ANDKYHKPVLHNKILMKDISENHWQQNVLKDGNLFIELFKSYELVPDLFSLYEWSEWITPSIFNRRFHTAFYIFISDSSVETNINEDESCSISWVIPEEIVHEPSSYK-ELAPPQFLELLAMNSLFSIRDIQVAALRRQQKSGGISN-MTKVISLSNGKLIVLPGDSRYPADHKDEIDLSHFSFIDLEKDENLNRFFVSDGLFNFRYNLNGSNFN 1027
            S ++  +  SA+LI++    +     D++VL+L+R + S       VFPGGV+DK DF+++W ++F + +     N   L  ++  +  V+ K     + +  +I  RICAIRETFEE+GIL+    ++DK       N  L KD  +N W++ V  D ++F  + + +E VPD+++L EWS W+TP+   RR+ T FYI   D       ++ E     W+IP E   +  + K ++  PQ  ELL         D Q  + +R + S G    +T +    +G L+V P D  YP+ HK  ++       +L K        ++      + N  G+NFN
Sbjct:    2 SATRPLIRNSATLILVARNSQLKSPFDWRVLLLERAAKSTFMPSMYVFPGGVIDKADFSNDWMELFKQSFTKFGTNFTPLVDVQGPRPPVVKKSGS--TDLPSDIALRICAIRETFEESGILLLKSFSSDK------QNSHLEKDSIQN-WRKEVHADASMFFTMCRKFECVPDVWALSEWSNWLTPAHLPRRYDTMFYISFLDEEPLALHDDTEMTHSKWMIPAEASAKYRARKIKIGFPQAYELLRFCRFPKWEDFQ--SFQRNRASDGCEQWLTIITQCVDGTLVVFPHDDLYPSLHKRVME-------ELTKTSTGQIPILNQSETLLQLNSKGTNFN 325
[Close]
BLAST of Nucleoside diphosphate-linked moiety X motif 19 vs. TrEMBL
Match: T1KXY3 (Nudix hydrolase domain-containing protein OS=Tetranychus urticae OX=32264 GN=107368255 PE=4 SV=1)

HSP 1 Score: 145.206 bits (365), Expect = 1.535e-36
Identity = 94/289 (32.53%), Postives = 147/289 (50.87%), Query Frame = 2 
Query:  116 FKVLMLKRISSSQSFAGKMVFPGGVLDKCDFNDEWNKIFN-------------KKYNLPQL-------NSLKCDKEMVIYKDSKDLSKIKPEIFYRICAIRETFEETGILIANDKYHKPVLHNKILMKDISENHWQQNVLKDGNLFIELFKSYELVPDLFSLYEWSEWITP-SIFNRRFHTAFYIFISDSSVETNINEDESCSISWVIPEEIVHEPSSYKE-LAPPQFLELLAMNSLFSIRDIQVAALRRQQKSGGISNMTKVI-SLSNGKLIVLPGDSRYPADHKDEI 913
            F +LM KR   +       VFPGG L+  DF+ EW K+FN             K+ N P+          L   ++      SKD + +  +I  RICAIRETFEETG+L+A++        N I +  IS  +W+  V ++ N FI+     ++ P+++ LYEWS W+TP ++ +RRF T FYI+ + +  ET+ ++ E  +I W  P E++      K  LAPPQ  EL  +++     +++    +R+  S G+     +I   ++G +  LPGD  Y  D K  I
Sbjct:   31 FNLLMTKRSDKASFLGSAFVFPGGHLETSDFSPEWWKVFNQAGFSESHVNSVVKRINGPRTPIITECQTKLAAQQQFSSSSSSKD-NVLPSDIGLRICAIRETFEETGVLLAHNS------SNSIQLDAISVENWRSKVRENANDFIQFCLEMKIAPNIWDLYEWSNWLTPNALGHRRFDTMFYIYCTSNKPETDSDQKEVATIEWYTPNELLDLQKQQKAFLAPPQVYELSRLSNFKEFHELKDFVFKRE--SDGVERWIPLIKGYADGSVFFLPGDDSYGLDIKTSI 310
[Close]
BLAST of Nucleoside diphosphate-linked moiety X motif 19 vs. TrEMBL
Match: A0A162SSA6 (Nucleoside diphosphate-linked moiety X motif 19 OS=Daphnia magna OX=35525 GN=APZ42_011558 PE=4 SV=1)

HSP 1 Score: 144.436 bits (363), Expect = 3.053e-36
Identity = 94/268 (35.07%), Postives = 143/268 (53.36%), Query Frame = 2 
Query:  113 DFKVLMLKRISSSQSFAGKMVFPGGVLDKCDFNDEWNKIFNKK-YNLPQLNS---LKCDKEMVIYKDSKDLSKIKPEIFYRICAIRETFEETGILIANDKYHKPVLHNKILMKDISENHWQQNVLKDGNLFIELFKSYELVPDLFSLYEWSEWITPS-IFNRRFHTAFYIFISDSSVETNINEDESCSISWVIP-EEIVHEPSSYKELAPPQFLELLAMNSLFSIRDIQVAALRRQQKSGGISNMTKVISLS-NGKLIVLPGDSRYPA 895
            D+  ++LKR S S+ FA   VFPGG  +  DF+  W + F++  +N  +L S   +    ++ +Y D  + S   PE+ YRI AIRETFEETG+L           ++ +   D+ E  WQ+ +  +   F+ L K Y L+PDL+SLYEWS W+TP+ +  +R+ T FY+ + D+  +  I+  E   + W  P   I+     +  LAPPQ  EL     + ++ D+++    RQQK  GI     + S S  G   +LPGDS YP 
Sbjct:   38 DYSCMLLKRSSQSKFFANAFVFPGGATEVADFSPSWLEHFDEHGFNREKLASQFVVSQQDKVPLYADIPN-SDCIPEVGYRISAIRETFEETGVLFCKPAQIHGQSNSILKADDLIE--WQKRIHHNPEEFLILCKKYFLLPDLWSLYEWSNWLTPTNMGPKRYDTMFYVCVIDNIPDVRIDGKEITQVLWTDPYNAILKHVQGHIWLAPPQLYELCRFAQIGTVEDLKIFCKSRQQK--GIERWLPIRSQSEEGYTTILPGDSLYPV 300
[Close]
BLAST of Nucleoside diphosphate-linked moiety X motif 19 vs. TrEMBL
Match: A0A084W8Q8 (AGAP009926-PA-like protein OS=Anopheles sinensis OX=74873 GN=ZHAS_00014642 PE=4 SV=1)

HSP 1 Score: 144.436 bits (363), Expect = 3.286e-36
Identity = 92/272 (33.82%), Postives = 137/272 (50.37%), Query Frame = 2 
Query:  113 DFKVLMLKRISSSQSFAGKMVFPGGVLDKCDFNDEWNKIFNKKY----NLPQLNSLKCDKEMVIYKDSKDLSKIKPEIFYRICAIRETFEETGILIANDKYHKPVLHNKI--LMKDISENHWQQNVLKDGNLFIELFKSYELVPDLFSLYEWSEWITPSIFN-RRFHTAFYIFISDSSVETNINEDESCSISWVIPEEIVHEPSSYKE-LAPPQFLELLAMNSLFSIRDIQVAALRRQQKSGGISNMTKV-ISLSNGKLIVLPGDSRYPADH 901
            ++KVLM KR   +      +VFPGG  D+ D   EW  +F ++      L +L  +   +  +   +S D  ++   +  R+CA+RE FEE GIL+A          N     +K +    WQ+ +      F EL     +VPDLFSLYEWS W+TP++F  RRF TAFY+ + +     +  E E     W  P  ++    + K  LAPPQ  EL  ++ L  I  I   A+ R +K  G + +  V  ++S+G + VLPGD  YPAD+
Sbjct:   31 NYKVLMFKRTEKTSFMPSSVVFPGGGFDRQDGALEWTTVFEQRGVAIDKLKRLTEVTGSRPYIFQTESND--QLDRNVSLRLCALREAFEELGILLAGPVAELDARTNGYSQCLKSLDVPSWQRRIHDGTASFRELHSELGVVPDLFSLYEWSCWLTPTMFRKRRFETAFYLAVLNEIPSVHPEEHEVAEYLWDTPAALLEAHRAEKLWLAPPQTYELTRLSHLHDIDQIVRFAIERNRK--GSTLLCPVQYTVSDGVVFVLPGDDLYPADY 298
[Close]
BLAST of Nucleoside diphosphate-linked moiety X motif 19 vs. Ensembl Cavefish
Match: nudt19 (nudix hydrolase 19 [Source:NCBI gene;Acc:103032236])

HSP 1 Score: 120.553 bits (301), Expect = 1.363e-30
Identity = 87/317 (27.44%), Postives = 151/317 (47.63%), Query Frame = 2 
Query:  113 DFKVLMLKRISSSQSFAGKMVFPGGVLDKCDFNDEWNKIFNKKYNLPQLN------SLKCDKEMVIYKDSKDLSKIKPEIFYRICAIRETFEETGILIANDKYHKPVLHNKILMKDISE-------NHWQQNVLKDGNLFIELFKSYELVPDLFSLYEWSEWITPSIFN---RRFHTAFYIFISDSSVETNINEDESCSISWVIPEEIVHEPSSYKE----LAPPQFLELLAMNSLFSIRDIQVAALRRQQKSGGISNMTKV-ISLSNGKLIVLPGDSRYP--ADHKDEIDLSHFSFIDLE----KDENLNRFFVSD 982
            ++KVL+LKR   S       VFPGG+ +  DF+ EW  +F     LP           +    M      K  S +  ++ +RICA+RETFEE G+L+   +       ++ +   +SE         W+  V+++ + FI + +  + +P++++++EW  W+TP   +   RR+ TAFY+       +T  +E E     W  P E++    S+++    +APPQF +L  M++   + D+   A  R  +  G      V ++ ++  + +LPGDS YP   D+  +   S  S   LE    +  NL+R  + D
Sbjct:   35 NYKVLLLKRSGKSGFMPNAHVFPGGLAEASDFSPEWLDLFEPFRTLPNFGVGLVKQPPETRPPMFATDRLKLGSPVPGDVAFRICAVRETFEEAGVLLVVPRKDAAEHRSRSVPAALSELCDRSEMARWRSLVIQNSSNFIHMCRELQCLPNIWAMHEWGNWLTPIGLHGKQRRYDTAFYLCCLKDIPDTVQDEKEIVHFEWSTPSEVLR---SFRDREVWIAPPQFYDLGRMSNFHLLSDLHDFAKSRSVE--GCEQWLPVHLAATDCHVSLLPGDSMYPETPDYTGKTKSSLPSEKSLEELQKESPNLHRIVIHD 346
[Close]
BLAST of Nucleoside diphosphate-linked moiety X motif 19 vs. Ensembl Nematostella
Match: EDO34652 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7SNP6])

HSP 1 Score: 132.88 bits (333), Expect = 2.515e-36
Identity = 94/296 (31.76%), Postives = 152/296 (51.35%), Query Frame = 2 
Query:   59 KSASLXXXXXXXXXXXXXDFKVLMLKRISSSQSFAGKMVFPGGVLDKCDFNDEWNKIFNKKY----NLPQLNSLKCDKEMVIYKDSKDLSKIKPEIFYRICAIRETFEETGILIANDKYHKPVLHNKI------LMKDISE---NHWQQNVLKDGNLFIELFKSYELVPDLFSLYEWSEWITPSIFNRRFHTAFYI-FISDSSVETNINEDESCSISWVIPEEIVHEPSSYKEL-APPQF---LELLAMNSLFSIRDIQVAALRRQQKSGGISNMTKVISLSNGKLIVLPGDSRYP 892
            +SA+LI++          D++VL+L+R S S+    + VFPGGV+DKCDF DEW +++ K +    +  ++  +K  +  +  K +   + I  EI +RICAIRETFEE+GIL+      K    N +      + +D+       W+  V  DG+ FI L +  + VPD+++L EWS+W+TP+    RF T F++ F++   V  + N+ E     W  P E V +    K L  PPQ    L+     S  + ++ Q    + +   G    +T ++   +G + V PGD  YP
Sbjct:   11 ESATLIMLARNGGLRSPFDYRVLLLERNSKSRFMPNREVFPGGVIDKCDFADEWMELYEKSFQKLEDFSRILDIKKPRPPIFRKSN---TSIPTEIAFRICAIRETFEESGILLLRS-MSKGESENSLSWGAASVFEDLPTEEVQRWRTAVHNDGSQFIHLCRFLQSVPDVWALTEWSDWLTPASVKIRFDTVFFMCFVNYEPVAQHDNK-EMIESKWKTPVEAVVDTIKKKALFGPPQLYNALQFCGFTSWETFKEFQ----QSRAHEGCDQMLTIILKCKDGIVAVKPGDDLYP 297
[Close]
BLAST of Nucleoside diphosphate-linked moiety X motif 19 vs. Ensembl Medaka
Match: nudt19 (nudix hydrolase 19 [Source:NCBI gene;Acc:101172065])

HSP 1 Score: 141.739 bits (356), Expect = 2.238e-38
Identity = 103/314 (32.80%), Postives = 154/314 (49.04%), Query Frame = 2 
Query:  113 DFKVLMLKRISSSQSFAGKMVFPGGVLDKCDFNDEWNKIFNKKYNLPQLNSLKCDKEMVIYKDS-------KDLSKIKPEIFYRICAIRETFEETGILIANDKYH-------KPVLHNKILMKDISE-NHWQQNVLKDGNLFIELFKSYELVPDLFSLYEWSEWITP-SIFNRRFHTAFYIFISDSSVETNINEDESCSISWVIPEEIVHEPSSYKE----LAPPQFLELLAMNSLFSIRDIQVAALRRQQKSGGISNMTKVISLSNGKLI-VLPGDSRYPADHKDEIDLSHFSFIDL---EKDENLNRFFVSD 982
            D+ VL+LKR + S       VFPGGVLD  DF+ +W  IF    + P    L+  K+ V  + +       K  S I  ++  RICA+RETFEE+G+L+   K          P  H K     ++E + W+  V ++   FI + +  E++P++++L+EW+ WITP  I+ RRF TAF+         T  +E E     W  P EI+     Y+E    +APPQF EL  M  L  + D+   A +R  +  G      V  L N + I +LPGD +YP D   +++       +L   EK   L+R  + D
Sbjct:   58 DYDVLLLKRSAKSGFMPNAYVFPGGVLDPSDFSGDWLDIFKPFSSCPNFG-LRQTKQPVETRPAIFATDRLKLGSPIPGDVALRICALRETFEESGVLLVVPKAEVKSFKDDCPSKHYKEPPFSVNELSQWRALVNQNPTNFIRMCRELEVLPNIWALHEWANWITPVGIYGRRFDTAFFQCCLQEIPHTIQDEKEIVDFQWSTPSEILQ---CYQERQMWMAPPQFYELSRMCCLPRLNDLHSFAYKRAVE--GCERWLPVALLENEQYISLLPGDKQYPQDTSGQMEADRTPDHELNNPEKQSALHRMTIKD 365
[Close]
BLAST of Nucleoside diphosphate-linked moiety X motif 19 vs. Planmine SMEST
Match: SMESG000019809.1 (SMESG000019809.1)

HSP 1 Score: 612.453 bits (1578), Expect = 0.000e+0
Identity = 299/300 (99.67%), Postives = 299/300 (99.67%), Query Frame = 2 
Query:  128 MLKRISSSQSFAGKMVFPGGVLDKCDFNDEWNKIFNKKYNLPQLNSLKCDKEMVIYKDSKDLSKIKPEIFYRICAIRETFEETGILIANDKYHKPVLHNKILMKDISENHWQQNVLKDGNLFIELFKSYELVPDLFSLYEWSEWITPSIFNRRFHTAFYIFISDSSVETNINEDESCSISWVIPEEIVHEPSSYKELAPPQFLELLAMNSLFSIRDIQVAALRRQQKSGGISNMTKVISLSNGKLIVLPGDSRYPADHKDEIDLSHFSFIDLEKDENLNRFFVSDGLFNFRYNLNGSNFN 1027
            MLKRISSSQSFAGKMVFPGGVLDKCDFNDEWNKIFNKKYNLPQLNSLKCDKEMVIYKDSKDLSKIKPEIFYRICAIRETFEETGILIANDKYHKPVLHNKILMKDISENHWQQNVLKDGNLFIELFKSYELVPDLFSLYEWSEWITPSIFNRRFHTAFYIFISDSSVETNINEDESCSISWVIPEEIVHEPSSYKELAPPQFLELLAMNSLFSIRDI VAALRRQQKSGGISNMTKVISLSNGKLIVLPGDSRYPADHKDEIDLSHFSFIDLEKDENLNRFFVSDGLFNFRYNLNGSNFN
Sbjct:    1 MLKRISSSQSFAGKMVFPGGVLDKCDFNDEWNKIFNKKYNLPQLNSLKCDKEMVIYKDSKDLSKIKPEIFYRICAIRETFEETGILIANDKYHKPVLHNKILMKDISENHWQQNVLKDGNLFIELFKSYELVPDLFSLYEWSEWITPSIFNRRFHTAFYIFISDSSVETNINEDESCSISWVIPEEIVHEPSSYKELAPPQFLELLAMNSLFSIRDIHVAALRRQQKSGGISNMTKVISLSNGKLIVLPGDSRYPADHKDEIDLSHFSFIDLEKDENLNRFFVSDGLFNFRYNLNGSNFN 300
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BLAST of Nucleoside diphosphate-linked moiety X motif 19 vs. Planmine SMEST
Match: SMESG000019809.1 (SMESG000019809.1)

HSP 1 Score: 402.905 bits (1034), Expect = 7.259e-143
Identity = 197/198 (99.49%), Postives = 197/198 (99.49%), Query Frame = 2 
Query:  434 MKDISENHWQQNVLKDGNLFIELFKSYELVPDLFSLYEWSEWITPSIFNRRFHTAFYIFISDSSVETNINEDESCSISWVIPEEIVHEPSSYKELAPPQFLELLAMNSLFSIRDIQVAALRRQQKSGGISNMTKVISLSNGKLIVLPGDSRYPADHKDEIDLSHFSFIDLEKDENLNRFFVSDGLFNFRYNLNGSNFN 1027
            MKDISENHWQQNVLKDGNLFIELFKSYELVPDLFSLYEWSEWITPSIFNRRFHTAFYIFISDSSVETNINEDESCSISWVIPEEIVHEPSSYKELAPPQFLELLAMNSLFSIRDI VAALRRQQKSGGISNMTKVISLSNGKLIVLPGDSRYPADHKDEIDLSHFSFIDLEKDENLNRFFVSDGLFNFRYNLNGSNFN
Sbjct:    1 MKDISENHWQQNVLKDGNLFIELFKSYELVPDLFSLYEWSEWITPSIFNRRFHTAFYIFISDSSVETNINEDESCSISWVIPEEIVHEPSSYKELAPPQFLELLAMNSLFSIRDIHVAALRRQQKSGGISNMTKVISLSNGKLIVLPGDSRYPADHKDEIDLSHFSFIDLEKDENLNRFFVSDGLFNFRYNLNGSNFN 198
The following BLAST results are available for this feature:
BLAST of Nucleoside diphosphate-linked moiety X motif 19 vs. Ensembl Human
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Human e!99)
Total hits: 1
Match NameE-valueIdentityDescription
NUDT191.511e-2428.10nudix hydrolase 19 [Source:HGNC Symbol;Acc:HGNC:32... [more]
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BLAST of Nucleoside diphosphate-linked moiety X motif 19 vs. Ensembl Celegans
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99)
Total hits: 1
Match NameE-valueIdentityDescription
ndx-75.931e-1628.37Putative nudix hydrolase 7 [Source:UniProtKB/Swis... [more]
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BLAST of Nucleoside diphosphate-linked moiety X motif 19 vs. Ensembl Fly
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99)
Total hits: 5
Match NameE-valueIdentityDescription
CG101946.853e-3734.04gene:FBgn0032790 transcript:FBtr0081285[more]
CG180945.022e-2629.21gene:FBgn0032791 transcript:FBtr0331324[more]
CG180945.022e-2629.21gene:FBgn0032791 transcript:FBtr0081243[more]
CG101954.823e-2126.59gene:FBgn0032787 transcript:FBtr0332318[more]
CG101954.823e-2126.59gene:FBgn0032787 transcript:FBtr0302930[more]
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BLAST of Nucleoside diphosphate-linked moiety X motif 19 vs. Ensembl Zebrafish
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99)
Total hits: 2
Match NameE-valueIdentityDescription
nudt191.188e-3330.53nudix (nucleoside diphosphate linked moiety X)-typ... [more]
nudt193.787e-3129.46nudix (nucleoside diphosphate linked moiety X)-typ... [more]
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BLAST of Nucleoside diphosphate-linked moiety X motif 19 vs. Ensembl Xenopus
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99)
Total hits: 1
Match NameE-valueIdentityDescription
acss31.779e-3228.48acyl-CoA synthetase short chain family member 3 [S... [more]
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BLAST of Nucleoside diphosphate-linked moiety X motif 19 vs. Ensembl Mouse
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99)
Total hits: 1
Match NameE-valueIdentityDescription
Nudt197.727e-2828.47nudix (nucleoside diphosphate linked moiety X)-typ... [more]
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BLAST of Nucleoside diphosphate-linked moiety X motif 19 vs. UniProt/SwissProt
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt)
Total hits: 5
Match NameE-valueIdentityDescription
sp|Q5PQ50|NUD19_XENLA3.679e-3329.58Nucleoside diphosphate-linked moiety X motif 19 OS... [more]
sp|Q7M0H3|NUD19_MUSCR7.039e-3028.47Nucleoside diphosphate-linked moiety X motif 19 OS... [more]
sp|Q5ZL13|NUD19_CHICK6.039e-2929.89Nucleoside diphosphate-linked moiety X motif 19 OS... [more]
sp|P11930|NUD19_MOUSE5.405e-2728.47Nucleoside diphosphate-linked moiety X motif 19 OS... [more]
sp|Q7M0H4|NUD19_MUSSA9.551e-2728.10Nucleoside diphosphate-linked moiety X motif 19 OS... [more]
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BLAST of Nucleoside diphosphate-linked moiety X motif 19 vs. TrEMBL
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL)
Total hits: 5
Match NameE-valueIdentityDescription
A0A2G8JYJ72.198e-3730.63Putative nucleoside diphosphate-linked moiety X mo... [more]
A0A2B4RLM41.001e-3630.41Nucleoside diphosphate-linked moiety X motif 19, m... [more]
T1KXY31.535e-3632.53Nudix hydrolase domain-containing protein OS=Tetra... [more]
A0A162SSA63.053e-3635.07Nucleoside diphosphate-linked moiety X motif 19 OS... [more]
A0A084W8Q83.286e-3633.82AGAP009926-PA-like protein OS=Anopheles sinensis O... [more]
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BLAST of Nucleoside diphosphate-linked moiety X motif 19 vs. Ensembl Cavefish
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99)
Total hits: 1
Match NameE-valueIdentityDescription
nudt191.363e-3027.44nudix hydrolase 19 [Source:NCBI gene;Acc:103032236... [more]
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BLAST of Nucleoside diphosphate-linked moiety X motif 19 vs. Ensembl Sea Lamprey
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99)
Total hits: 0
Match NameE-valueIdentityDescription
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BLAST of Nucleoside diphosphate-linked moiety X motif 19 vs. Ensembl Yeast
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46)
Total hits: 0
Match NameE-valueIdentityDescription
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BLAST of Nucleoside diphosphate-linked moiety X motif 19 vs. Ensembl Nematostella
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46)
Total hits: 1
Match NameE-valueIdentityDescription
EDO346522.515e-3631.76Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7... [more]
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BLAST of Nucleoside diphosphate-linked moiety X motif 19 vs. Ensembl Medaka
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99)
Total hits: 1
Match NameE-valueIdentityDescription
nudt192.238e-3832.80nudix hydrolase 19 [Source:NCBI gene;Acc:101172065... [more]
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BLAST of Nucleoside diphosphate-linked moiety X motif 19 vs. Planmine SMEST
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST)
Total hits: 2
Match NameE-valueIdentityDescription
SMESG000019809.10.000e+099.67SMESG000019809.1[more]
SMESG000019809.17.259e-14399.49SMESG000019809.1[more]
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Sequences
The following sequences are available for this feature:

transcript sequence

>SMED30011214 ID=SMED30011214|Name=Nucleoside diphosphate-linked moiety X motif 19|organism=Schmidtea mediterranea sexual|type=transcript|length=1054bp
CAAGGTCAAGTTATTTTATTATTAATCTATATACAGTTTTTCGAAAATGT
CTGTTATAAAATCTGCATCTTTAATTATAATTAATTCAATTCAAAAACAA
ATAAAAAAAAATGATTTTAAGGTTCTAATGTTAAAACGAATTTCTTCAAG
TCAGTCATTTGCTGGTAAAATGGTTTTTCCTGGAGGAGTTCTTGATAAAT
GTGATTTTAATGACGAATGGAATAAGATCTTCAACAAAAAATATAATCTT
CCTCAACTTAATTCTTTAAAGTGCGATAAAGAAATGGTAATTTATAAAGA
TTCTAAAGATCTTTCTAAAATTAAACCAGAAATATTTTACAGAATTTGCG
CAATTCGTGAAACATTTGAAGAAACTGGGATTCTAATAGCGAATGATAAA
TATCATAAACCGGTTTTACACAACAAGATTCTTATGAAAGATATTTCAGA
AAATCACTGGCAACAGAATGTACTGAAAGATGGAAATTTATTCATTGAAT
TATTCAAGTCTTACGAGCTAGTTCCTGATTTGTTTTCTCTCTATGAATGG
TCCGAGTGGATTACTCCGTCTATCTTCAATCGTCGATTTCATACTGCCTT
CTATATTTTCATTAGCGATAGTTCAGTGGAAACAAATATAAATGAAGACG
AGTCATGTTCAATCAGTTGGGTAATTCCAGAGGAAATTGTCCACGAGCCT
TCATCCTACAAGGAATTAGCGCCTCCTCAGTTTTTGGAATTATTAGCAAT
GAACTCTTTGTTTTCAATCCGAGACATTCAAGTAGCGGCTTTGCGGCGGC
AGCAGAAATCCGGAGGAATCAGCAACATGACAAAGGTCATATCTCTCTCA
AACGGGAAATTAATTGTGCTCCCTGGAGATTCGCGCTATCCCGCAGATCA
CAAAGATGAAATCGATTTGTCACATTTTTCATTTATTGATTTGGAGAAAG
ATGAAAATCTTAACAGATTTTTTGTCAGTGATGGATTATTTAATTTCCGC
TACAATTTGAATGGGAGCAATTTCAACAGTTAATTGAAAAATAGAAATTT
TTAC
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protein sequence of SMED30011214-orf-1

>SMED30011214-orf-1 ID=SMED30011214-orf-1|Name=SMED30011214-orf-1|organism=Schmidtea mediterranea sexual|type=polypeptide|length=329bp
MSVIKSASLIIINSIQKQIKKNDFKVLMLKRISSSQSFAGKMVFPGGVLD
KCDFNDEWNKIFNKKYNLPQLNSLKCDKEMVIYKDSKDLSKIKPEIFYRI
CAIRETFEETGILIANDKYHKPVLHNKILMKDISENHWQQNVLKDGNLFI
ELFKSYELVPDLFSLYEWSEWITPSIFNRRFHTAFYIFISDSSVETNINE
DESCSISWVIPEEIVHEPSSYKELAPPQFLELLAMNSLFSIRDIQVAALR
RQQKSGGISNMTKVISLSNGKLIVLPGDSRYPADHKDEIDLSHFSFIDLE
KDENLNRFFVSDGLFNFRYNLNGSNFNS*
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Annotated Terms
The following terms have been associated with this transcript:
Vocabulary: Planarian Anatomy
TermDefinition
PLANA:0000136whole organism
PLANA:0002089reproductive organ
Vocabulary: INTERPRO
TermDefinition
IPR039121NUDT19
IPR015797NUDIX_hydrolase-like_dom_sf
IPR000086NUDIX_hydrolase_dom
Vocabulary: molecular function
TermDefinition
GO:0016787hydrolase activity
InterPro
Analysis Name: Schmidtea mediteranean smed_20140614 Interproscan
Date Performed: 2020-05-01
IPR TermIPR DescriptionSourceSource TermSource DescriptionAlignment
NoneNo IPR availableGENE3DG3DSA:3.90.79.10coord: 1..256
e-value: 3.6E-54
score: 185.7
IPR039121Nucleoside diphosphate-linked moiety X motif 19PANTHERPTHR12318TESTOSTERONE-REGULATED PROTEIN RP2coord: 5..310
IPR000086NUDIX hydrolase domainPROSITEPS51462NUDIXcoord: 2..231
score: 11.612
IPR015797NUDIX hydrolase-like domain superfamilySUPERFAMILYSSF55811Nudixcoord: 21..221