WD_REPEATS_REGION domain-containing protein

Overview
NameWD_REPEATS_REGION domain-containing protein
Smed IDSMED30011092
Length (bp)916
Neoblast Clusters

Zeng et. al., 2018



▻ Overview

▻ Neoblast Population

▻ Sub-lethal Irradiated Surviving X1 and X2 Cell Population

 

 

Overview

 

Single cell RNA-seq of pluripotent neoblasts and its early progenies


We isolated X1 neoblasts cells enriched in high piwi-1 expression (Neoblast Population), and profiled ∼7,614 individual cells via scRNA-seq. Unsupervised analyses uncovered 12 distinct classes from 7,088 high-quality cells. We designated these classes Nb1 to Nb12 and ordered them based on high (Nb1) to low (Nb12) piwi-1 expression levels. We further defined groups of genes that best classified the cells parsed into 12 distinct cell clusters to generate a scaled expression heat map of discriminative gene sets for each cluster. Expression of each cluster’s gene signatures was validated using multiplex fluorescence in situ hybridization (FISH) co-stained with piwi-1 and largely confirmed the cell clusters revealed by scRNA-seq.

We also tested sub-lethal irradiation exposure. To profile rare pluripotent stem cells (PSCs) and avoid interference from immediate progenitor cells, we determined a time point after sub-lethal irradiation (7 DPI) with minimal piwi-1+ cells, followed by isolation and single-cell RNA-seq of 1,200 individual cells derived from X1 (Piwi-1 high) and X2 (Piwi-1 low) cell populations (Sub-lethal Irradiated Surviving X1 and X2 Cell Population)



Explore this single cell expression dataset with our NB Cluster Shiny App



 

Neoblast Population

 

t-SNE plot shows two-dimensional representation of global gene expression relationships among all neoblasts (n = 7,088 after filter). Cluster identity was assigned based on the top 10 marker genes of each cluster (Table S2), followed by inspection of RNA in situ hybridization patterns. Neoblast groups, Nb.


Expression of WD_REPEATS_REGION domain-containing protein (SMED30011092) t-SNE clustered cells

Violin plots show distribution of expression levels for WD_REPEATS_REGION domain-containing protein (SMED30011092) in cells (dots) of each of the 12 neoblast clusters.

 

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Sub-lethal Irradiated Surviving X1 and X2 Cell Population

 

t-SNE plot of surviving X1 and X2 cells (n = 1,039 after QC filter) after sub-lethal irradiation. Colors indicate unbiased cell classification via graph-based clustering. SL, sub-lethal irradiated cell groups.

Expression of WD_REPEATS_REGION domain-containing protein (SMED30011092) in the t-SNE clustered sub-lethally irradiated X1 and X2 cells.

Violin plots show distribution of expression levels for WD_REPEATS_REGION domain-containing protein (SMED30011092) in cells (dots) of each of the 10 clusters of sub-leathally irradiated X1 and X2 cells.

 

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Embryonic Expression

Davies et. al., 2017

Hover the mouse over a column in the graph to view average RPKM values per sample.
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Embryonic Stages: Y: yolk. S2-S8: Stages 2-8. C4: asexual adult. SX: virgin, sexually mature adult.
For further information about sample preparation and analysis for the single animal RNA-Seq experiment, please refer to the Materials and Methods

 

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Anatomical Expression

PAGE et. al., 2020



SMED30011092

has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGE



PAGE Curations: 8

  
Expressed InReference TranscriptGene ModelsPublished TranscriptTranscriptomePublicationSpecimenLifecycleEvidence
X1 cellSMED30011092h1SMcG0003267 SmedASXL_012755SmedAsxl_ww_GCZZ01PMID:26114597
Zhu et al., 2015		FACS sorted cell population asexual adult RNA-sequencing evidence
X1 cellSMED30011092h1SMcG0003267 SmedASXL_004094SmedAsxl_ww_GCZZ01PMID:26114597
Zhu et al., 2015		FACS sorted cell population asexual adult RNA-sequencing evidence
nervous systemSMED30011092h1SMcG0003267 dd_Smed_v4_29867_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018		FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
cephalic gangliaSMED30011092h1SMcG0003267 dd_Smed_v4_29867_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018		FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
nervous systemSMED30011092h1SMcG0003267 dd_Smed_v4_74366_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018		FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
cephalic gangliaSMED30011092h1SMcG0003267 dd_Smed_v4_74366_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018		FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
zeta neoblastSMED30011092h1SMcG0003267 dd_Smed_v4_29867_0_1dd_Smed_v4PMID:28292427
Wurtzel et al., 2017		whole organism asexual adult single-cell RNA-sequencing evidence
zeta neoblastSMED30011092h1SMcG0003267 dd_Smed_v4_21908_0_1dd_Smed_v4PMID:28292427
Wurtzel et al., 2017		whole organism asexual adult single-cell RNA-sequencing evidence
Note: Hover over icons to view figure legend
Homology
[Close]
BLAST of WD_REPEATS_REGION domain-containing protein vs. Ensembl Human
Match: NWD2 (NACHT and WD repeat domain containing 2 [Source:HGNC Symbol;Acc:HGNC:29229])

HSP 1 Score: 117.472 bits (293), Expect = 1.200e-28
Identity = 52/138 (37.68%), Postives = 87/138 (63.04%), Query Frame = 1 
Query:  490 IRIFLSSTFTDTTLERNIIMKNAYPKLKEYCKKVYGLDFQIVDMRWGIRDEATDDHKTTELCLQEIENCKRLSIGPRFVALLGDKYGYRPVPRKIIAQDFENIKSVNSLSKLDLEILNNWYKLDSNTAPHMFVSQPIS 903
            +R+F+S+   DT  ER  + +N YPKL+E+C++ YGL+FQ++D+ WG+ ++  D  +  +  ++ +ENC + S GP FV LLG+KYG   +P ++ A +FE I      +KL+ ++L  WY  D N+ P  +  +P S
Sbjct:   41 VRVFISANPEDTGAERQALRENVYPKLREFCRENYGLEFQVIDLYWGVEEDEWDSPELQKTRMKLLENCLKTSAGPCFVGLLGEKYGNIRIPGEVEASEFEMILDAAIEAKLETKLLEEWYCRDENSVPAAYYLRPKS 178
[Close]
BLAST of WD_REPEATS_REGION domain-containing protein vs. Ensembl Human
Match: NWD1 (NACHT and WD repeat domain containing 1 [Source:HGNC Symbol;Acc:HGNC:27619])

HSP 1 Score: 100.908 bits (250), Expect = 3.347e-25
Identity = 48/116 (41.38%), Postives = 76/116 (65.52%), Query Frame = 1 
Query:  553 NAYPKLK--EYCKKVYGLDFQIVDMRWGIRDEATDDHKTTELCLQEIENCKRLSIGPRFVALLGDKYGYRPVPRKIIAQDFENIKSVNSLSKLDLEILNNWYKLDSNTAPHMFVSQ 894
             A P LK   +C++ +GL F++VD+RWGIR+    DH TTELCL+E++ C + SIGP FVAL+GD+YG   +P +I  +++E ++   +    DLE++  +++ D N  P  +V Q
Sbjct:    8 RALPTLKCQTFCQR-HGLMFEVVDLRWGIRNIEATDHLTTELCLEEVDRCWKTSIGPAFVALIGDQYGPCLIPSRIDEKEWEVLRDHLTARPSDLELVARYFQRDENAFPPTYVLQ 122
[Close]
BLAST of WD_REPEATS_REGION domain-containing protein vs. Ensembl Human
Match: NWD1 (NACHT and WD repeat domain containing 1 [Source:HGNC Symbol;Acc:HGNC:27619])

HSP 1 Score: 101.293 bits (251), Expect = 3.713e-23
Identity = 48/115 (41.74%), Postives = 76/115 (66.09%), Query Frame = 1 
Query:  556 AYPKLK--EYCKKVYGLDFQIVDMRWGIRDEATDDHKTTELCLQEIENCKRLSIGPRFVALLGDKYGYRPVPRKIIAQDFENIKSVNSLSKLDLEILNNWYKLDSNTAPHMFVSQ 894
            A P LK   +C++ +GL F++VD+RWGIR+    DH TTELCL+E++ C + SIGP FVAL+GD+YG   +P +I  +++E ++   +    DLE++  +++ D N  P  +V Q
Sbjct:    9 ALPTLKCQTFCQR-HGLMFEVVDLRWGIRNIEATDHLTTELCLEEVDRCWKTSIGPAFVALIGDQYGPCLIPSRIDEKEWEVLRDHLTARPSDLELVARYFQRDENAFPPTYVLQ 122
[Close]
BLAST of WD_REPEATS_REGION domain-containing protein vs. Ensembl Human
Match: NWD1 (NACHT and WD repeat domain containing 1 [Source:HGNC Symbol;Acc:HGNC:27619])

HSP 1 Score: 101.293 bits (251), Expect = 3.713e-23
Identity = 48/115 (41.74%), Postives = 76/115 (66.09%), Query Frame = 1 
Query:  556 AYPKLK--EYCKKVYGLDFQIVDMRWGIRDEATDDHKTTELCLQEIENCKRLSIGPRFVALLGDKYGYRPVPRKIIAQDFENIKSVNSLSKLDLEILNNWYKLDSNTAPHMFVSQ 894
            A P LK   +C++ +GL F++VD+RWGIR+    DH TTELCL+E++ C + SIGP FVAL+GD+YG   +P +I  +++E ++   +    DLE++  +++ D N  P  +V Q
Sbjct:    9 ALPTLKCQTFCQR-HGLMFEVVDLRWGIRNIEATDHLTTELCLEEVDRCWKTSIGPAFVALIGDQYGPCLIPSRIDEKEWEVLRDHLTARPSDLELVARYFQRDENAFPPTYVLQ 122
[Close]
BLAST of WD_REPEATS_REGION domain-containing protein vs. Ensembl Human
Match: NWD1 (NACHT and WD repeat domain containing 1 [Source:HGNC Symbol;Acc:HGNC:27619])

HSP 1 Score: 101.293 bits (251), Expect = 3.713e-23
Identity = 48/115 (41.74%), Postives = 76/115 (66.09%), Query Frame = 1 
Query:  556 AYPKLK--EYCKKVYGLDFQIVDMRWGIRDEATDDHKTTELCLQEIENCKRLSIGPRFVALLGDKYGYRPVPRKIIAQDFENIKSVNSLSKLDLEILNNWYKLDSNTAPHMFVSQ 894
            A P LK   +C++ +GL F++VD+RWGIR+    DH TTELCL+E++ C + SIGP FVAL+GD+YG   +P +I  +++E ++   +    DLE++  +++ D N  P  +V Q
Sbjct:    9 ALPTLKCQTFCQR-HGLMFEVVDLRWGIRNIEATDHLTTELCLEEVDRCWKTSIGPAFVALIGDQYGPCLIPSRIDEKEWEVLRDHLTARPSDLELVARYFQRDENAFPPTYVLQ 122
[Close]
BLAST of WD_REPEATS_REGION domain-containing protein vs. Ensembl Celegans
Match: T05C3.2 (pep chromosome:WBcel235:V:5493747:5503010:1 gene:WBGene00020254.1 transcript:T05C3.2.1 gene_biotype:protein_coding transcript_biotype:protein_coding gene_symbol:T05C3.2)

HSP 1 Score: 176.022 bits (445), Expect = 2.907e-49
Identity = 95/202 (47.03%), Postives = 136/202 (67.33%), Query Frame = 1 
Query:  307 LKNEIISLEKNNSQSTKNESIIKTEINKKNCNIE--NPEECGILINNVYRGIINETQNLKNGIIRIFLSSTFTDTTLERNIIMKNAYPKLKEYCKKVYGLDFQIVDMRWGIRDEATDDHKTTELCLQEIENCKRLSIGPRFVALLGDKYGYRPVPRKIIAQDFENIKSVNSLSKLDLEILNNWYKLDSNTAPHMFVSQPISS 906
            + N +   E  NS+ST    ++ ++ N++   +E  +P    I  + V+ G ++     ++ ++R+F SSTFTDTT+ERN +M+  YPKLKEYC++ YGLDFQ+VDMRWG+RDE+TDDH TT+LCL EI NC+RLS+G  FV  L  KYGYRP+P +I++ + E +K        D+ +L+NWY  DSN+ P MFV Q ISS
Sbjct:   39 IPNHLQKKENGNSRSTTGLDMLLSQNNEQKQVVERRDPYTQEIF-DRVFSGKLSNIPKPQSKLVRVFTSSTFTDTTVERNALMEEIYPKLKEYCRETYGLDFQVVDMRWGVRDESTDDHMTTKLCLSEIANCQRLSVGANFVVFLCQKYGYRPIPSEILSTELEMLKRTLREEHEDISLLDNWYIEDSNSVPPMFVLQQISS 239
[Close]
BLAST of WD_REPEATS_REGION domain-containing protein vs. Ensembl Fly
Match: CG10185 (gene:FBgn0038397 transcript:FBtr0083235)

HSP 1 Score: 169.859 bits (429), Expect = 5.171e-47
Identity = 83/158 (52.53%), Postives = 116/158 (73.42%), Query Frame = 1 
Query:  433 INNVYRGIINETQNLKNGIIRIFLSSTFTDTTLERNIIMKNAYPKLKEYCKKVYGLDFQIVDMRWGIRDEATDDHKTTELCLQEIENCKRLSIGPRFVALLGDKYGYRPVPRKIIAQDFENIKSVNSLSKLDLEILNNWYKLDSNTAPHMFVSQPISS 906
            I++++ G +     + + I+RIF SSTFTDTT+ERN +M   YP++K+YC++ +GL+FQ+VDMRWG+RDEATDDH TTELC++EI+NC+RLS+GP F+  LG KYGYRP+P  I++ +   I    +   +D  IL+ WYK DSN  P + V QPISS
Sbjct:    6 IDSIFLGSLESLPPVSSKIVRIFTSSTFTDTTMERNTLMAKCYPRIKDYCREKHGLEFQVVDMRWGVRDEATDDHMTTELCMREIKNCQRLSMGPNFIVFLGQKYGYRPIPTYIVSSELALICEELTSMGVDRAILDLWYKKDSNAVPPISVLQPISS 163
[Close]
BLAST of WD_REPEATS_REGION domain-containing protein vs. Ensembl Zebrafish
Match: nwd1 (NACHT and WD repeat domain containing 1 [Source:ZFIN;Acc:ZDB-GENE-071116-8])

HSP 1 Score: 129.413 bits (324), Expect = 6.417e-33
Identity = 62/154 (40.26%), Postives = 98/154 (63.64%), Query Frame = 1 
Query:  442 VYRGIINETQNLKNGIIRIFLSSTFTDTTLERNIIMKNAYPKLKEYCKKVYGLDFQIVDMRWGIRDEATDDHKTTELCLQEIENCKRLSIGPRFVALLGDKYGYRPVPRKIIAQDFENIKSVNSLSKLDLEILNNWYKLDSNTAPHMFVSQPIS 903
            V RG   ++    + ++R+F+SST +D   ERN   +  Y +L+ +C+ + GL F++VD + G+RD    DH  TELC++EIE C+R+S GP F+AL+G++YG+R VPR I   +FE + S  S     L++LN W+  DSN+ P  ++  PI+
Sbjct:   14 VLRGQSADSLQPTSRMVRVFISSTHSDMKNERNAFWEKTYSELQTHCQSL-GLVFEVVDFKCGMRDITASDHLITELCIKEIETCQRISDGPTFIALIGNQYGHRLVPRLIPEAEFELLLSKLSKDPESLKLLNQWFYKDSNSIPPTYILLPIT 166
[Close]
BLAST of WD_REPEATS_REGION domain-containing protein vs. Ensembl Zebrafish
Match: nwd2 (NACHT and WD repeat domain containing 2 [Source:ZFIN;Acc:ZDB-GENE-161213-1])

HSP 1 Score: 112.849 bits (281), Expect = 3.498e-27
Identity = 51/136 (37.50%), Postives = 82/136 (60.29%), Query Frame = 1 
Query:  490 IRIFLSSTFTDTTLERNIIMKNAYPKLKEYCKKVYGLDFQIVDMRWGIRDEATDDHKTTELCLQEIENCKRLSIGPRFVALLGDKYGYRPVPRKIIAQDFENIKSVNSLSKLDLEILNNWYKLDSNTAPHMFVSQP 897
            +R+F+ +   DT  ERN + ++ YPKL+++C++ YG++FQ+VD+ WGI  E  D  +   L ++ +E C + S GP FV L+G+KYG   VP ++ + +FE I      + LD  IL  WY  D N+ P  +  +P
Sbjct:   41 VRVFICANPDDTEAERNALKEHVYPKLRDFCRENYGIEFQVVDLYWGIDPEEWDSPELQRLRMKLLEECLKTSAGPCFVGLIGEKYGSIRVPGEVESAEFEMILDAAVEAGLDTRILEEWYCRDENSVPPAYYLKP 176
[Close]
BLAST of WD_REPEATS_REGION domain-containing protein vs. Ensembl Zebrafish
Match: CU570791.3 (NACHT and WD repeat domain-containing protein 2-like [Source:NCBI gene;Acc:108179119])

HSP 1 Score: 80.1073 bits (196), Expect = 3.990e-16
Identity = 43/134 (32.09%), Postives = 75/134 (55.97%), Query Frame = 1 
Query:  490 IRIFLSSTFTDTTLERNIIMKNAYPKLKEYCKKVYGLDFQIVDMRWGIRDEAT--DDHKTTELCLQEIENCKRLSIGPRFVALLGDKYGYRPVPRKIIAQDFENIKSVNSLSKLDLEILNNWYKLDSNTAPHMF 885
            ++++L S   D+ +ER +I +  +P+L+EYC+  YGLDF+++D       EAT   +  T +  L+ +E+C   S+   FV L+G++YG   +P ++ A +F+ I  V        ++L   Y+ D NT P  F
Sbjct:    4 VQVYLCSNPEDSVVERTLIRQKVFPRLREYCRSTYGLDFRVIDPY-----EATKPKNWPTQQERLRILEDCWNNSLHSFFVGLVGEQYGDACLPEQVEASEFQLILQVCQRMGFKTDVLEKCYRRDENTIPPSF 132
[Close]
BLAST of WD_REPEATS_REGION domain-containing protein vs. Ensembl Zebrafish
Match: si:ch211-212k18.6 (si:ch211-212k18.6 [Source:ZFIN;Acc:ZDB-GENE-130530-938])

HSP 1 Score: 68.5514 bits (166), Expect = 2.416e-12
Identity = 35/109 (32.11%), Postives = 57/109 (52.29%), Query Frame = 1 
Query:  472 NLKNGIIRIFLSSTFTDTTLERNIIMKNAYPKLKEYCKKVYGLDFQIVDMRWGIRDEATDDHKTTELCLQEIENCKRLSIGPRFVALLGDKYGYRPVPRKIIAQDFENI 798
            N K     I+L   + DT  ER  +M++ YP+L  +CK+  G DF+++D+R G+ D  +D H   E+ ++ +  C+    GP F    G K+    +P  I   DFE +
Sbjct:  222 NYKQRRFMIYLCGGYKDTIPERCALMESVYPRLYLHCKQ-RGYDFKMIDLRAGVGDPDSDRHDLAEMHIETLRRCQDTE-GPNFFVFTGQKHEILSLPNTIPQADFEAV 328
[Close]
BLAST of WD_REPEATS_REGION domain-containing protein vs. Ensembl Xenopus
Match: ppp1r3c.1 (protein phosphatase 1, regulatory (inhibitor) subunit 3C, gene 1 [Source:Xenbase;Acc:XB-GENE-969181])

HSP 1 Score: 139.813 bits (351), Expect = 2.156e-36
Identity = 59/127 (46.46%), Postives = 93/127 (73.23%), Query Frame = 1 
Query:  532 ERNIIMKNAYPKLKEYCKKVYGLDFQIVDMRWGIRDEATDDHKTTELCLQEIENCKRLSIGPRFVALLGDKYGYRPVPRKIIAQDFENIKSVNSLSKLDLEILNNWYKLDSNTAPHMFVSQPISSEI 912
            ERN +M+ AYP ++ +C+K +GL F++VDMRWG+RD AT DH+T ELCL+EI+ C++ S+GP F+AL+G++YG+RP+PR I  ++F  + S    ++ D ++L  W+  D NT P  +V QPI++ +
Sbjct:    4 ERNALMEFAYPDIQAFCQK-HGLGFEVVDMRWGVRDYATVDHRTKELCLKEIDFCQKTSMGPSFIALVGNRYGFRPIPRVISEEEFNILFSKIQSNESDAQLLTKWFWKDMNTIPPTYVLQPITTHL 129
[Close]
BLAST of WD_REPEATS_REGION domain-containing protein vs. Ensembl Xenopus
Match: hsp90ab1 (heat shock protein 90kDa alpha family class B member 1 [Source:Xenbase;Acc:XB-GENE-495311])

HSP 1 Score: 108.997 bits (271), Expect = 9.883e-26
Identity = 51/138 (36.96%), Postives = 83/138 (60.14%), Query Frame = 1 
Query:  490 IRIFLSSTFTDTTLERNIIMKNAYPKLKEYCKKVYGLDFQIVDMRWGIRDEATDDHKTTELCLQEIENCKRLSIGPRFVALLGDKYGYRPVPRKIIAQDFENIKSVNSLSKLDLEILNNWYKLDSNTAPHMFVSQPIS 903
            +R+F+ ST+  T  ERN + ++ YPKL+E+C++ YG++FQ++D+ WGI +E  D     +  ++ +E C + S GP FV LLG+KYG   +P ++ + +FE I      +KL+   L  WY  D N  P  +  +P S
Sbjct:   41 VRVFIMSTY-HTEAERNELREHVYPKLREFCRENYGMEFQVIDLYWGIPEEDWDSPDLQKTRMRLLEECLKTSAGPCFVGLLGEKYGTIRIPGEVESSEFEMILDAAIEAKLETRTLEEWYCRDENAVPPAYYLRPKS 177
[Close]
BLAST of WD_REPEATS_REGION domain-containing protein vs. Ensembl Xenopus
Match: hs3st5 (heparan sulfate-glucosamine 3-sulfotransferase 5 [Source:Xenbase;Acc:XB-GENE-5795358])

HSP 1 Score: 66.6254 bits (161), Expect = 1.379e-11
Identity = 36/90 (40.00%), Postives = 52/90 (57.78%), Query Frame = 1 
Query:  490 IRIFLSSTFTDTTLERNIIMKNAYPKLKEYCKKVYGLDFQIVDMRWGIRDEATDDHKTTELCLQEIENCKRLSIGPRFVALLGDKYGYRP 759
            IRIF+SSTF D   ERN+I+    P+L+      Y L  + VD+RWGI +E T   +   LCL E+  C+       F+ +LG++YG+ P
Sbjct: 1007 IRIFISSTFRDMHSERNLIIGQVIPELRSRAACHY-LSVEEVDLRWGITEEETRKDRQLHLCLSEV--CR----SQIFIGILGERYGHVP 1089
[Close]
BLAST of WD_REPEATS_REGION domain-containing protein vs. Ensembl Xenopus
Match: ENSXETT00000022477.1 (pep primary_assembly:Xenopus_tropicalis_v9.1:KV460486.1:142089:157740:1 gene:ENSXETG00000010819.1 transcript:ENSXETT00000022477.1 gene_biotype:protein_coding transcript_biotype:protein_coding)

HSP 1 Score: 63.929 bits (154), Expect = 1.251e-10
Identity = 31/77 (40.26%), Postives = 46/77 (59.74%), Query Frame = 1 
Query:  532 ERNIIMKNAYPKLKEYCKKVYGLDFQIVDMRWGIRDEATDDHKTTELCLQEIENCKRLSIGPRFV---ALLGDKYGY 753
            ER  +    YPKL+EYC++VYGL+FQ+VD   GI  E     +  ++ +Q +E C +  +GP FV   A+L   +GY
Sbjct:   22 ERRALRNRVYPKLREYCRQVYGLEFQVVDAYEGIHYEEYYSPRVQKIRMQLLEGCLKQPVGPCFVVSLAVLKQYWGY 98
[Close]
BLAST of WD_REPEATS_REGION domain-containing protein vs. Ensembl Mouse
Match: Nwd1 (NACHT and WD repeat domain containing 1 [Source:MGI Symbol;Acc:MGI:2442268])

HSP 1 Score: 135.576 bits (340), Expect = 5.949e-35
Identity = 61/139 (43.88%), Postives = 95/139 (68.35%), Query Frame = 1 
Query:  490 IRIFLSSTFTDTTLERNIIMKNAYPKLKEYCKKVYGLDFQIVDMRWGIRDEATDDHKTTELCLQEIENCKRLSIGPRFVALLGDKYGYRPVPRKIIAQDFENIKSVNSLSKLDLEILNNWYKLDSNTAPHMFVSQPISS 906
            + IF+SST +D   ER  +   AYP+++ +C++ +GL F++VD+RWGI +    D+ TTELCL+E+E C++ SIGP FVALLGD+YG  PVPR+I  +++E +++  +    DLE++   ++ D NT P  +V QP  S
Sbjct:   31 VVIFISSTISDMDTEREALQCTAYPEVQSFCQR-HGLAFEVVDLRWGIPNTQATDYLTTELCLEELERCQKTSIGPAFVALLGDQYGPCPVPRRIEEKEWEALRAQLTSRPRDLELVTRHFQRDDNTIPPTYVLQPSGS 168
[Close]
BLAST of WD_REPEATS_REGION domain-containing protein vs. Ensembl Mouse
Match: Nwd1 (NACHT and WD repeat domain containing 1 [Source:MGI Symbol;Acc:MGI:2442268])

HSP 1 Score: 123.635 bits (309), Expect = 6.566e-31
Identity = 55/125 (44.00%), Postives = 86/125 (68.80%), Query Frame = 1 
Query:  532 ERNIIMKNAYPKLKEYCKKVYGLDFQIVDMRWGIRDEATDDHKTTELCLQEIENCKRLSIGPRFVALLGDKYGYRPVPRKIIAQDFENIKSVNSLSKLDLEILNNWYKLDSNTAPHMFVSQPISS 906
            ER  +   AYP+++ +C++ +GL F++VD+RWGI +    D+ TTELCL+E+E C++ SIGP FVALLGD+YG  PVPR+I  +++E +++  +    DLE++   ++ D NT P  +V QP  S
Sbjct:    4 EREALQCTAYPEVQSFCQR-HGLAFEVVDLRWGIPNTQATDYLTTELCLEELERCQKTSIGPAFVALLGDQYGPCPVPRRIEEKEWEALRAQLTSRPRDLELVTRHFQRDDNTIPPTYVLQPSGS 127
[Close]
BLAST of WD_REPEATS_REGION domain-containing protein vs. Ensembl Mouse
Match: Nwd1 (NACHT and WD repeat domain containing 1 [Source:MGI Symbol;Acc:MGI:2442268])

HSP 1 Score: 123.635 bits (309), Expect = 6.597e-31
Identity = 55/125 (44.00%), Postives = 86/125 (68.80%), Query Frame = 1 
Query:  532 ERNIIMKNAYPKLKEYCKKVYGLDFQIVDMRWGIRDEATDDHKTTELCLQEIENCKRLSIGPRFVALLGDKYGYRPVPRKIIAQDFENIKSVNSLSKLDLEILNNWYKLDSNTAPHMFVSQPISS 906
            ER  +   AYP+++ +C++ +GL F++VD+RWGI +    D+ TTELCL+E+E C++ SIGP FVALLGD+YG  PVPR+I  +++E +++  +    DLE++   ++ D NT P  +V QP  S
Sbjct:    4 EREALQCTAYPEVQSFCQR-HGLAFEVVDLRWGIPNTQATDYLTTELCLEELERCQKTSIGPAFVALLGDQYGPCPVPRRIEEKEWEALRAQLTSRPRDLELVTRHFQRDDNTIPPTYVLQPSGS 127
[Close]
BLAST of WD_REPEATS_REGION domain-containing protein vs. Ensembl Mouse
Match: Nwd2 (NACHT and WD repeat domain containing 2 [Source:MGI Symbol;Acc:MGI:1920464])

HSP 1 Score: 116.316 bits (290), Expect = 2.166e-28
Identity = 50/136 (36.76%), Postives = 86/136 (63.24%), Query Frame = 1 
Query:  490 IRIFLSSTFTDTTLERNIIMKNAYPKLKEYCKKVYGLDFQIVDMRWGIRDEATDDHKTTELCLQEIENCKRLSIGPRFVALLGDKYGYRPVPRKIIAQDFENIKSVNSLSKLDLEILNNWYKLDSNTAPHMFVSQP 897
            +R+F+S+   DT  ER  + +  YPKL+E+C++ YGL+FQ++D+ WGI ++  D  +  ++ ++ +E C + S GP FV LLG+KYG   +P ++ A +FE I      +KL+ ++L +WY  D N+ P  +  +P
Sbjct:   41 VRVFISANPEDTGAERQALRETVYPKLREFCRENYGLEFQVIDLYWGIEEDEWDSPELQKMRMKLLEECLKTSAGPCFVGLLGEKYGNIRIPGEVEASEFEMILDAAVEAKLETKLLEDWYCRDENSVPAAYYLRP 176
[Close]
BLAST of WD_REPEATS_REGION domain-containing protein vs. Ensembl Mouse
Match: Nwd1 (NACHT and WD repeat domain containing 1 [Source:MGI Symbol;Acc:MGI:2442268])

HSP 1 Score: 79.337 bits (194), Expect = 1.452e-18
Identity = 33/69 (47.83%), Postives = 50/69 (72.46%), Query Frame = 1 
Query:  532 ERNIIMKNAYPKLKEYCKKVYGLDFQIVDMRWGIRDEATDDHKTTELCLQEIENCKRLSIGPRFVALLG 738
            ER  +   AYP+++ +C++ +GL F++VD+RWGI +    D+ TTELCL+E+E C++ SIGP FV L G
Sbjct:    4 EREALQCTAYPEVQSFCQR-HGLAFEVVDLRWGIPNTQATDYLTTELCLEELERCQKTSIGPAFVLLSG 71
[Close]
BLAST of WD_REPEATS_REGION domain-containing protein vs. UniProt/SwissProt
Match: sp|A6H603|NWD1_MOUSE (NACHT domain- and WD repeat-containing protein 1 OS=Mus musculus OX=10090 GN=Nwd1 PE=2 SV=2)

HSP 1 Score: 123.635 bits (309), Expect = 4.615e-30
Identity = 55/125 (44.00%), Postives = 86/125 (68.80%), Query Frame = 1 
Query:  532 ERNIIMKNAYPKLKEYCKKVYGLDFQIVDMRWGIRDEATDDHKTTELCLQEIENCKRLSIGPRFVALLGDKYGYRPVPRKIIAQDFENIKSVNSLSKLDLEILNNWYKLDSNTAPHMFVSQPISS 906
            ER  +   AYP+++ +C++ +GL F++VD+RWGI +    D+ TTELCL+E+E C++ SIGP FVALLGD+YG  PVPR+I  +++E +++  +    DLE++   ++ D NT P  +V QP  S
Sbjct:    4 EREALQCTAYPEVQSFCQR-HGLAFEVVDLRWGIPNTQATDYLTTELCLEELERCQKTSIGPAFVALLGDQYGPCPVPRRIEEKEWEALRAQLTSRPRDLELVTRHFQRDDNTIPPTYVLQPSGS 127
[Close]
BLAST of WD_REPEATS_REGION domain-containing protein vs. UniProt/SwissProt
Match: sp|Q9ULI1|NWD2_HUMAN (NACHT and WD repeat domain-containing protein 2 OS=Homo sapiens OX=9606 GN=NWD2 PE=2 SV=3)

HSP 1 Score: 117.472 bits (293), Expect = 5.763e-28
Identity = 52/138 (37.68%), Postives = 87/138 (63.04%), Query Frame = 1 
Query:  490 IRIFLSSTFTDTTLERNIIMKNAYPKLKEYCKKVYGLDFQIVDMRWGIRDEATDDHKTTELCLQEIENCKRLSIGPRFVALLGDKYGYRPVPRKIIAQDFENIKSVNSLSKLDLEILNNWYKLDSNTAPHMFVSQPIS 903
            +R+F+S+   DT  ER  + +N YPKL+E+C++ YGL+FQ++D+ WG+ ++  D  +  +  ++ +ENC + S GP FV LLG+KYG   +P ++ A +FE I      +KL+ ++L  WY  D N+ P  +  +P S
Sbjct:   41 VRVFISANPEDTGAERQALRENVYPKLREFCRENYGLEFQVIDLYWGVEEDEWDSPELQKTRMKLLENCLKTSAGPCFVGLLGEKYGNIRIPGEVEASEFEMILDAAIEAKLETKLLEEWYCRDENSVPAAYYLRPKS 178
[Close]
BLAST of WD_REPEATS_REGION domain-containing protein vs. UniProt/SwissProt
Match: sp|Q6P5U7|NWD2_MOUSE (NACHT and WD repeat domain-containing protein 2 OS=Mus musculus OX=10090 GN=Nwd2 PE=1 SV=2)

HSP 1 Score: 116.316 bits (290), Expect = 1.515e-27
Identity = 50/136 (36.76%), Postives = 86/136 (63.24%), Query Frame = 1 
Query:  490 IRIFLSSTFTDTTLERNIIMKNAYPKLKEYCKKVYGLDFQIVDMRWGIRDEATDDHKTTELCLQEIENCKRLSIGPRFVALLGDKYGYRPVPRKIIAQDFENIKSVNSLSKLDLEILNNWYKLDSNTAPHMFVSQP 897
            +R+F+S+   DT  ER  + +  YPKL+E+C++ YGL+FQ++D+ WGI ++  D  +  ++ ++ +E C + S GP FV LLG+KYG   +P ++ A +FE I      +KL+ ++L +WY  D N+ P  +  +P
Sbjct:   41 VRVFISANPEDTGAERQALRETVYPKLREFCRENYGLEFQVIDLYWGIEEDEWDSPELQKMRMKLLEECLKTSAGPCFVGLLGEKYGNIRIPGEVEASEFEMILDAAVEAKLETKLLEDWYCRDENSVPAAYYLRP 176
[Close]
BLAST of WD_REPEATS_REGION domain-containing protein vs. UniProt/SwissProt
Match: sp|Q149M9|NWD1_HUMAN (NACHT domain- and WD repeat-containing protein 1 OS=Homo sapiens OX=9606 GN=NWD1 PE=1 SV=3)

HSP 1 Score: 101.293 bits (251), Expect = 1.811e-22
Identity = 48/115 (41.74%), Postives = 76/115 (66.09%), Query Frame = 1 
Query:  556 AYPKLK--EYCKKVYGLDFQIVDMRWGIRDEATDDHKTTELCLQEIENCKRLSIGPRFVALLGDKYGYRPVPRKIIAQDFENIKSVNSLSKLDLEILNNWYKLDSNTAPHMFVSQ 894
            A P LK   +C++ +GL F++VD+RWGIR+    DH TTELCL+E++ C + SIGP FVAL+GD+YG   +P +I  +++E ++   +    DLE++  +++ D N  P  +V Q
Sbjct:    9 ALPTLKCQTFCQR-HGLMFEVVDLRWGIRNIEATDHLTTELCLEEVDRCWKTSIGPAFVALIGDQYGPCLIPSRIDEKEWEVLRDHLTARPSDLELVARYFQRDENAFPPTYVLQ 122
[Close]
BLAST of WD_REPEATS_REGION domain-containing protein vs. UniProt/SwissProt
Match: sp|O08653|TEP1_RAT (Telomerase protein component 1 OS=Rattus norvegicus OX=10116 GN=Tep1 PE=1 SV=1)

HSP 1 Score: 71.2478 bits (173), Expect = 2.774e-12
Identity = 34/90 (37.78%), Postives = 54/90 (60.00%), Query Frame = 1 
Query:  490 IRIFLSSTFTDTTLERNIIMKNAYPKLKEYCKKVYGLDFQIVDMRWGIRDEATDDHKTTELCLQEIENCKRLSIGPRFVALLGDKYGYRP 759
            IR+F+SSTF D   ER+++M++  P L+      + +    +D+RWGI +E T  ++  E+CL E+EN +       FV +LG +YGY P
Sbjct:  912 IRLFISSTFRDMHGERDLLMRSVLPALQARAFP-HRISLHAIDLRWGITEEETRRNRQLEVCLGEVENSQ------LFVGILGSRYGYTP 994
[Close]
BLAST of WD_REPEATS_REGION domain-containing protein vs. TrEMBL
Match: A0A4Y2SYV7 (NACHT and WD repeat domain-containing protein 2 OS=Araneus ventricosus OX=182803 GN=NWD2_3 PE=4 SV=1)

HSP 1 Score: 194.897 bits (494), Expect = 6.504e-57
Identity = 81/158 (51.27%), Postives = 116/158 (73.42%), Query Frame = 1 
Query:  433 INNVYRGIINETQNLKNGIIRIFLSSTFTDTTLERNIIMKNAYPKLKEYCKKVYGLDFQIVDMRWGIRDEATDDHKTTELCLQEIENCKRLSIGPRFVALLGDKYGYRPVPRKIIAQDFENIKSVNSLSKLDLEILNNWYKLDSNTAPHMFVSQPISS 906
            I+ ++ G ++    + + I+RIF SSTFTD ++ERN +M+  YP++K++C++ +GL+FQ+VDMRWG+RDEATDDH TT+LC++EIENC+RLS+GP FV  LG KYGYRP+P  I  ++F  I     L   D  +L+ WY+ D+N  P +FV QPISS
Sbjct:    6 IDGIFLGCLDNLPPVSSKIVRIFTSSTFTDMSMERNALMEEVYPRIKDFCREKHGLEFQVVDMRWGVRDEATDDHMTTDLCMREIENCQRLSMGPNFVTFLGQKYGYRPIPTIIDGKEFRMIHDTLGLMSQDTSLLDRWYREDTNAVPSVFVLQPISS 163
[Close]
BLAST of WD_REPEATS_REGION domain-containing protein vs. TrEMBL
Match: A0A4Y2TZM9 (NACHT and WD repeat domain-containing protein 2 OS=Araneus ventricosus OX=182803 GN=NWD2_6 PE=4 SV=1)

HSP 1 Score: 194.512 bits (493), Expect = 7.335e-57
Identity = 81/158 (51.27%), Postives = 116/158 (73.42%), Query Frame = 1 
Query:  433 INNVYRGIINETQNLKNGIIRIFLSSTFTDTTLERNIIMKNAYPKLKEYCKKVYGLDFQIVDMRWGIRDEATDDHKTTELCLQEIENCKRLSIGPRFVALLGDKYGYRPVPRKIIAQDFENIKSVNSLSKLDLEILNNWYKLDSNTAPHMFVSQPISS 906
            I+ ++ G ++    + + I+RIF SSTFTD ++ERN +M+  YP++K++C++ +GL+FQ+VDMRWG+RDEATDDH TT+LC++EIENC+RLS+GP FV  LG KYGYRP+P  I  ++F  I     L   D  +L+ WY+ D+N  P +FV QPISS
Sbjct:    6 IDGIFLGCLDNLPPVSSKIVRIFTSSTFTDMSMERNALMEEVYPRIKDFCREKHGLEFQVVDMRWGVRDEATDDHMTTDLCMREIENCQRLSMGPNFVTFLGQKYGYRPIPTIIDGKEFRMIHDTLGLMSQDTSLLDRWYREDTNAVPSVFVLQPISS 163
[Close]
BLAST of WD_REPEATS_REGION domain-containing protein vs. TrEMBL
Match: A0A3M7PE77 (NACHT and WD repeat domain-containing 2 OS=Brachionus plicatilis OX=10195 GN=BpHYR1_019247 PE=4 SV=1)

HSP 1 Score: 205.682 bits (522), Expect = 7.212e-56
Identity = 89/159 (55.97%), Postives = 125/159 (78.62%), Query Frame = 1 
Query:  430 LINNVYRGIINETQNLKNGIIRIFLSSTFTDTTLERNIIMKNAYPKLKEYCKKVYGLDFQIVDMRWGIRDEATDDHKTTELCLQEIENCKRLSIGPRFVALLGDKYGYRPVPRKIIAQDFENIKSVNSLSKLDLEILNNWYKLDSNTAPHMFVSQPISS 906
            ++N ++ G      ++ + I+RIF SSTFTDT +ERN++M+  YPKLKEYC++ +GL+FQ+VDMRWG+RDE+TDDHKTTELC+QEI+NC+RLS+GP FV  LG KYGYRP+P +I+  +F  I  V+ L + D ++L  WYKLD+N+ P++FV QP+SS
Sbjct:   12 ILNRIFIGDFYNLPSIASKIVRIFTSSTFTDTAVERNLLMETVYPKLKEYCREQHGLEFQVVDMRWGVRDESTDDHKTTELCMQEIDNCQRLSLGPNFVVFLGQKYGYRPLPTRILDTEFNMI--VDILEESDAKLLMLWYKLDANSVPNVFVLQPVSS 168
[Close]
BLAST of WD_REPEATS_REGION domain-containing protein vs. TrEMBL
Match: T1J835 (Uncharacterized protein OS=Strigamia maritima OX=126957 PE=4 SV=1)

HSP 1 Score: 201.83 bits (512), Expect = 1.415e-54
Identity = 82/158 (51.90%), Postives = 122/158 (77.22%), Query Frame = 1 
Query:  433 INNVYRGIINETQNLKNGIIRIFLSSTFTDTTLERNIIMKNAYPKLKEYCKKVYGLDFQIVDMRWGIRDEATDDHKTTELCLQEIENCKRLSIGPRFVALLGDKYGYRPVPRKIIAQDFENIKSVNSLSKLDLEILNNWYKLDSNTAPHMFVSQPISS 906
            ++ ++ G +N+   + + I+RIF SSTFTDT++ERN +M+  YPKLK+YC++ +GL+FQ+VDMRWG+RDEATDDH TTELC++EI+NC+RLS+GP FV  LG KYGYRP+P  I+  +F +++     +  D+ +L+ WYK D+N+ P +++ QPISS
Sbjct:    6 VDRIFLGDLNDLPPVSSKIVRIFTSSTFTDTSMERNTLMEQVYPKLKDYCRERHGLEFQVVDMRWGVRDEATDDHMTTELCMKEIQNCQRLSMGPNFVVFLGQKYGYRPIPTIILGTEFVSLRQALVSAGTDVSLLDTWYKEDANSVPSVYILQPISS 163
[Close]
BLAST of WD_REPEATS_REGION domain-containing protein vs. TrEMBL
Match: A0A226DA16 (NACHT and WD repeat domain-containing protein 2 OS=Folsomia candida OX=158441 GN=Fcan01_23516 PE=4 SV=1)

HSP 1 Score: 194.126 bits (492), Expect = 7.021e-54
Identity = 86/159 (54.09%), Postives = 117/159 (73.58%), Query Frame = 1 
Query:  433 INNVYRG-IINETQNLKNGIIRIFLSSTFTDTTLERNIIMKNAYPKLKEYCKKVYGLDFQIVDMRWGIRDEATDDHKTTELCLQEIENCKRLSIGPRFVALLGDKYGYRPVPRKIIAQDFENIKSVNSLSKLDLEILNNWYKLDSNTAPHMFVSQPISS 906
            I+ V+ G ++ E   + + I+RIF SSTFTDT LERN +M   YPK+KEYC++ +GL+FQ+VDMRWG+RDEATDDH TTELC++EI NC+RLS+GP FV  LG KYGYRP+P  I+A +   +K       +D  +L+ WYK D+N  P++F+ QPIS+
Sbjct:    6 IDRVFSGCLVEELPPVSSKIVRIFTSSTFTDTALERNTLMAEVYPKIKEYCREKHGLEFQVVDMRWGVRDEATDDHMTTELCMREIINCQRLSMGPNFVVFLGQKYGYRPIPTIIMASELIMLKETLVQMGVDTYLLDLWYKKDTNAVPNVFILQPIST 164
[Close]
BLAST of WD_REPEATS_REGION domain-containing protein vs. Ensembl Cavefish
Match: nwd1 (NACHT and WD repeat domain containing 1 [Source:ZFIN;Acc:ZDB-GENE-071116-8])

HSP 1 Score: 133.265 bits (334), Expect = 2.400e-34
Identity = 63/144 (43.75%), Postives = 94/144 (65.28%), Query Frame = 1 
Query:  481 NGIIRIFLSSTFTDTTLERNIIMKNAYPKLKEYCKKVYGLDFQIVDMRWGIRDEATDDHKTTELCLQEIENCKRLSIGPRFVALLGDKYGYRPVPRKIIAQDFENIKSVNSLSKLDLE---ILNNWYKLDSNTAPHMFVSQPIS 903
            N I+ +   S  +D T ERN      YP+++++C+ + GL F++VD RWG+ D   +DH T ELCLQEI+ C++LS+GP F+AL+G +YG+RP+PR I   +FE + S   LS+ D E   +L  W+  DSN+ P  +V QPI+
Sbjct:    2 NIILCVTCKSHLSDLTSERNAFWDKIYPEIQDFCQSL-GLVFEVVDFRWGVSDSVINDHMTVELCLQEIQLCQKLSVGPSFLALVGSQYGHRPIPRFISENEFELLLS--KLSRKDQEGSMLLRQWFIKDSNSVPPKYVLQPIN 142
[Close]
BLAST of WD_REPEATS_REGION domain-containing protein vs. Ensembl Cavefish
Match: nwd2 (NACHT and WD repeat domain containing 2 [Source:NCBI gene;Acc:103039682])

HSP 1 Score: 112.079 bits (279), Expect = 5.162e-27
Identity = 50/136 (36.76%), Postives = 82/136 (60.29%), Query Frame = 1 
Query:  490 IRIFLSSTFTDTTLERNIIMKNAYPKLKEYCKKVYGLDFQIVDMRWGIRDEATDDHKTTELCLQEIENCKRLSIGPRFVALLGDKYGYRPVPRKIIAQDFENIKSVNSLSKLDLEILNNWYKLDSNTAPHMFVSQP 897
            +R+F+ +   DT  ERN + ++ YPKL+++C++ YG++FQ+VD+ WG+  E  D  +   L ++ +E C + S GP FV L+G+KYG   VP ++ + +FE I      + LD  IL  WY  D N+ P  +  +P
Sbjct:  118 VRVFICANPDDTEAERNALKEHVYPKLRDFCRENYGIEFQVVDLYWGVDPEEWDSPELQRLRMKLLEECLKTSAGPCFVGLVGEKYGSIRVPGEVESAEFEMILDAAVEAGLDTRILEEWYCRDENSVPPAYYLKP 253
[Close]
BLAST of WD_REPEATS_REGION domain-containing protein vs. Ensembl Cavefish
Match: nwd2 (NACHT and WD repeat domain containing 2 [Source:NCBI gene;Acc:103039682])

HSP 1 Score: 111.694 bits (278), Expect = 5.637e-27
Identity = 50/136 (36.76%), Postives = 82/136 (60.29%), Query Frame = 1 
Query:  490 IRIFLSSTFTDTTLERNIIMKNAYPKLKEYCKKVYGLDFQIVDMRWGIRDEATDDHKTTELCLQEIENCKRLSIGPRFVALLGDKYGYRPVPRKIIAQDFENIKSVNSLSKLDLEILNNWYKLDSNTAPHMFVSQP 897
            +R+F+ +   DT  ERN + ++ YPKL+++C++ YG++FQ+VD+ WG+  E  D  +   L ++ +E C + S GP FV L+G+KYG   VP ++ + +FE I      + LD  IL  WY  D N+ P  +  +P
Sbjct:   41 VRVFICANPDDTEAERNALKEHVYPKLRDFCRENYGIEFQVVDLYWGVDPEEWDSPELQRLRMKLLEECLKTSAGPCFVGLVGEKYGSIRVPGEVESAEFEMILDAAVEAGLDTRILEEWYCRDENSVPPAYYLKP 176
[Close]
BLAST of WD_REPEATS_REGION domain-containing protein vs. Ensembl Cavefish
Match: nwd2 (NACHT and WD repeat domain containing 2 [Source:NCBI gene;Acc:103039682])

HSP 1 Score: 111.694 bits (278), Expect = 5.968e-27
Identity = 50/136 (36.76%), Postives = 82/136 (60.29%), Query Frame = 1 
Query:  490 IRIFLSSTFTDTTLERNIIMKNAYPKLKEYCKKVYGLDFQIVDMRWGIRDEATDDHKTTELCLQEIENCKRLSIGPRFVALLGDKYGYRPVPRKIIAQDFENIKSVNSLSKLDLEILNNWYKLDSNTAPHMFVSQP 897
            +R+F+ +   DT  ERN + ++ YPKL+++C++ YG++FQ+VD+ WG+  E  D  +   L ++ +E C + S GP FV L+G+KYG   VP ++ + +FE I      + LD  IL  WY  D N+ P  +  +P
Sbjct:   41 VRVFICANPDDTEAERNALKEHVYPKLRDFCRENYGIEFQVVDLYWGVDPEEWDSPELQRLRMKLLEECLKTSAGPCFVGLVGEKYGSIRVPGEVESAEFEMILDAAVEAGLDTRILEEWYCRDENSVPPAYYLKP 176
[Close]
BLAST of WD_REPEATS_REGION domain-containing protein vs. Ensembl Cavefish
Match: nwd2 (NACHT and WD repeat domain containing 2 [Source:NCBI gene;Acc:103039682])

HSP 1 Score: 70.8626 bits (172), Expect = 3.681e-13
Identity = 35/106 (33.02%), Postives = 53/106 (50.00%), Query Frame = 1 
Query:  580 CKKVYGLDFQIVDMRWGIRDEATDDHKTTELCLQEIENCKRLSIGPRFVALLGDKYGYRPVPRKIIAQDFENIKSVNSLSKLDLEILNNWYKLDSNTAPHMFVSQP 897
            C         +VD+ WG+  E  D  +   L ++ +E C + S GP FV L+G+KYG   VP ++ + +FE I      + LD  IL  WY  D N+ P  +  +P
Sbjct:   68 CASSSAPTLTVVDLYWGVDPEEWDSPELQRLRMKLLEECLKTSAGPCFVGLVGEKYGSIRVPGEVESAEFEMILDAAVEAGLDTRILEEWYCRDENSVPPAYYLKP 173
[Close]
BLAST of WD_REPEATS_REGION domain-containing protein vs. Ensembl Nematostella
Match: EDO31117 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7SYV4])

HSP 1 Score: 174.866 bits (442), Expect = 3.612e-49
Identity = 76/161 (47.20%), Postives = 120/161 (74.53%), Query Frame = 1 
Query:  442 VYRGIINETQNLKNGIIRIFLSSTFTDTTLERNIIMKNAYPKLKEYCKKVYGLDFQIVDMRWGIRDEATDDHKTTELCLQEIENCKRLSIGPRFVALLGDKYGYRPVPRKIIAQDFENI----KSVNSLSKLDLEILNNWYKLDSNTAPHMFVSQPISSEI 912
            +  G I    + ++ I+RIF SSTFTDT  ERN++M++ YP L++YC++ + L+FQ+VDMRWG+RDEAT DHKT++LC+QEI+NC+RL+ GP +V  LG+KYGYRPVP KI A++FE++    + V ++ K ++++L  W+  + N  P  +V QP+++++
Sbjct:    8 ILTGDITNLPSKESNIVRIFTSSTFTDTFEERNLLMRDVYPSLRKYCQQ-HSLEFQVVDMRWGVRDEATADHKTSDLCIQEIKNCQRLTQGPNYVCFLGNKYGYRPVPYKINAEEFESLVDIAREVENVKKEEVDLLLEWFLKNENALPAEYVLQPVTAKL 167
[Close]
BLAST of WD_REPEATS_REGION domain-containing protein vs. Ensembl Nematostella
Match: EDO47108 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7RNA9])

HSP 1 Score: 168.703 bits (426), Expect = 7.137e-48
Identity = 73/140 (52.14%), Postives = 107/140 (76.43%), Query Frame = 1 
Query:  487 IIRIFLSSTFTDTTLERNIIMKNAYPKLKEYCKKVYGLDFQIVDMRWGIRDEATDDHKTTELCLQEIENCKRLSIGPRFVALLGDKYGYRPVPRKIIAQDFENIKS-VNSLSKLDLEILNNWYKLDSNTAPHMFVSQPIS 903
            I+RIF SSTFTDT++ERN +M+  YP++K++C++ +G +FQ+VDMRWG+RDE+TDDH T+ELC++E+  C+ LS GP F+  LG KYGYRP P KI A +FEN+ S VN++   D ++L +W++ D N  P  ++ QPI+
Sbjct:    2 IVRIFTSSTFTDTSVERNTLMERIYPRIKQFCQQ-HGYEFQVVDMRWGVRDESTDDHLTSELCMRELRACQELSTGPNFITFLGQKYGYRPFPPKIPATEFENLLSAVNNVE--DQQLLRHWFRRDDNIVPAEYLLQPIT 138
[Close]
BLAST of WD_REPEATS_REGION domain-containing protein vs. Ensembl Nematostella
Match: EDO41687 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7S3R7])

HSP 1 Score: 168.318 bits (425), Expect = 1.026e-47
Identity = 75/142 (52.82%), Postives = 105/142 (73.94%), Query Frame = 1 
Query:  487 IIRIFLSSTFTDTTLERNIIMKNAYPKLKEYCKKVYGLDFQIVDMRWGIRDEATDDHKTTELCLQEIENCKRLSIGPRFVALLGDKYGYRPVPRKIIAQDFENIKSVNSLSKLDLEILNNWYKLDSNTAPHMFVSQPISSEI 912
            I+RIF SSTFTDT++ERN +M   YP+L+ +C++  G DFQ+VD+RWGIR+EA DDH  TELC++EI+ C++LS GP F+  LG KYGYRP+P KI +++FE + SV + S  DL+++  WY  D N  P  ++ QPISS +
Sbjct:    2 IVRIFTSSTFTDTSVERNALMSRVYPRLQSFCRE-RGYDFQVVDLRWGIREEAVDDHILTELCMKEIKECQKLSTGPNFITFLGQKYGYRPLPHKIDSREFEKLLSVIT-STEDLDLVKYWYWRDDNNVPPEYILQPISSRL 141
[Close]
BLAST of WD_REPEATS_REGION domain-containing protein vs. Ensembl Nematostella
Match: EDO40517 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7S6Z9])

HSP 1 Score: 167.162 bits (422), Expect = 3.837e-47
Identity = 74/142 (52.11%), Postives = 104/142 (73.24%), Query Frame = 1 
Query:  487 IIRIFLSSTFTDTTLERNIIMKNAYPKLKEYCKKVYGLDFQIVDMRWGIRDEATDDHKTTELCLQEIENCKRLSIGPRFVALLGDKYGYRPVPRKIIAQDFENIKSVNSLSKLDLEILNNWYKLDSNTAPHMFVSQPISSEI 912
            I+RIF SSTFTDT  ERN +M+  YPKLKE+C++ +G +FQ+VDMRWG+RD +TDDH TTELCL E++ C++LS GP FV   G KYG+ P P KI++ +++ + S    ++ D ++L+ W+KLD N  P  +V QPISS+ 
Sbjct:   14 IVRIFTSSTFTDTQAERNTLMERVYPKLKEFCQE-HGYEFQVVDMRWGVRDASTDDHATTELCLCELKACQKLSTGPNFVTFFGQKYGFGPFPPKILSTEYDKLYSAVDNTE-DKKLLDVWFKLDENAVPPEYVLQPISSQF 153
[Close]
BLAST of WD_REPEATS_REGION domain-containing protein vs. Ensembl Nematostella
Match: EDO47107 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7RNA8])

HSP 1 Score: 166.392 bits (420), Expect = 4.698e-47
Identity = 71/139 (51.08%), Postives = 103/139 (74.10%), Query Frame = 1 
Query:  487 IIRIFLSSTFTDTTLERNIIMKNAYPKLKEYCKKVYGLDFQIVDMRWGIRDEATDDHKTTELCLQEIENCKRLSIGPRFVALLGDKYGYRPVPRKIIAQDFENIKSVNSLSKLDLEILNNWYKLDSNTAPHMFVSQPIS 903
            ++RIF SSTFTDT++ERN +M+  YP++K++C++  G +FQ+VDMRWG+RDE+TDDH T+ELC++E+  C+ LS GP F+  LG KYGYRP P KI A +FE + S    SK D ++L +W++ D N  P  ++ QPI+
Sbjct:    2 VVRIFTSSTFTDTSVERNTLMERIYPRIKQFCQQ-QGYEFQVVDMRWGVRDESTDDHLTSELCMRELRACQELSTGPNFITFLGQKYGYRPFPPKIPASEFEKLASAVG-SKEDKDLLYHWFRRDDNIVPAEYLLQPIT 138
[Close]
BLAST of WD_REPEATS_REGION domain-containing protein vs. Ensembl Medaka
Match: nwd2 (NACHT and WD repeat domain containing 2 [Source:NCBI gene;Acc:101165765])

HSP 1 Score: 112.464 bits (280), Expect = 3.030e-27
Identity = 50/136 (36.76%), Postives = 83/136 (61.03%), Query Frame = 1 
Query:  490 IRIFLSSTFTDTTLERNIIMKNAYPKLKEYCKKVYGLDFQIVDMRWGIRDEATDDHKTTELCLQEIENCKRLSIGPRFVALLGDKYGYRPVPRKIIAQDFENIKSVNSLSKLDLEILNNWYKLDSNTAPHMFVSQP 897
            +R+F+ +   DT  ERN + ++ YPKL+++C++ YG++FQ+VD+ WG+  E  D+ +   L ++ +E C + S GP FV L+G+KYG   VP ++ + +FE I      + LD  IL  WY  D N+ P  +  +P
Sbjct:   41 VRVFICANPDDTEAERNALKEHVYPKLRDFCRENYGIEFQVVDLYWGVDPEEWDNPELQRLRMKLLEECLKTSAGPCFVGLVGEKYGSIRVPGEVESAEFEMILDAAVEAGLDTHILEEWYCRDENSVPPAYYLKP 176
[Close]
BLAST of WD_REPEATS_REGION domain-containing protein vs. Ensembl Medaka
Match: nwd2 (NACHT and WD repeat domain containing 2 [Source:NCBI gene;Acc:101165765])

HSP 1 Score: 112.464 bits (280), Expect = 3.030e-27
Identity = 50/136 (36.76%), Postives = 83/136 (61.03%), Query Frame = 1 
Query:  490 IRIFLSSTFTDTTLERNIIMKNAYPKLKEYCKKVYGLDFQIVDMRWGIRDEATDDHKTTELCLQEIENCKRLSIGPRFVALLGDKYGYRPVPRKIIAQDFENIKSVNSLSKLDLEILNNWYKLDSNTAPHMFVSQP 897
            +R+F+ +   DT  ERN + ++ YPKL+++C++ YG++FQ+VD+ WG+  E  D+ +   L ++ +E C + S GP FV L+G+KYG   VP ++ + +FE I      + LD  IL  WY  D N+ P  +  +P
Sbjct:   41 VRVFICANPDDTEAERNALKEHVYPKLRDFCRENYGIEFQVVDLYWGVDPEEWDNPELQRLRMKLLEECLKTSAGPCFVGLVGEKYGSIRVPGEVESAEFEMILDAAVEAGLDTHILEEWYCRDENSVPPAYYLKP 176
[Close]
BLAST of WD_REPEATS_REGION domain-containing protein vs. Ensembl Medaka
Match: nwd2 (NACHT and WD repeat domain containing 2 [Source:NCBI gene;Acc:101165765])

HSP 1 Score: 112.464 bits (280), Expect = 3.268e-27
Identity = 50/136 (36.76%), Postives = 83/136 (61.03%), Query Frame = 1 
Query:  490 IRIFLSSTFTDTTLERNIIMKNAYPKLKEYCKKVYGLDFQIVDMRWGIRDEATDDHKTTELCLQEIENCKRLSIGPRFVALLGDKYGYRPVPRKIIAQDFENIKSVNSLSKLDLEILNNWYKLDSNTAPHMFVSQP 897
            +R+F+ +   DT  ERN + ++ YPKL+++C++ YG++FQ+VD+ WG+  E  D+ +   L ++ +E C + S GP FV L+G+KYG   VP ++ + +FE I      + LD  IL  WY  D N+ P  +  +P
Sbjct:   41 VRVFICANPDDTEAERNALKEHVYPKLRDFCRENYGIEFQVVDLYWGVDPEEWDNPELQRLRMKLLEECLKTSAGPCFVGLVGEKYGSIRVPGEVESAEFEMILDAAVEAGLDTHILEEWYCRDENSVPPAYYLKP 176
[Close]
BLAST of WD_REPEATS_REGION domain-containing protein vs. Ensembl Medaka
Match: nwd1 (NACHT and WD repeat domain containing 1 [Source:ZFIN;Acc:ZDB-GENE-071116-8])

HSP 1 Score: 96.6709 bits (239), Expect = 6.623e-22
Identity = 45/102 (44.12%), Postives = 65/102 (63.73%), Query Frame = 1 
Query:  598 LDFQIVDMRWGIRDEATDDHKTTELCLQEIENCKRLSIGPRFVALLGDKYGYRPVPRKIIAQDFENIKSVNSLSKLDLEILNNWYKLDSNTAPHMFVSQPIS 903
            L  Q+VD+ WGI +    DH+  E+ LQEI+ CKRLS GP F+ALLG++YG+R +PR I  + FE   S  S +   ++ L  W++ D+N  P  +V QPI+
Sbjct:   16 LPVQVVDLHWGIGNYPFGDHEACEISLQEIKMCKRLSAGPNFIALLGNRYGHRALPRLISEKQFEVYLSKLSQTPEGIKQLRLWFRKDTNAVPPTYVLQPIT 117
[Close]
BLAST of WD_REPEATS_REGION domain-containing protein vs. Ensembl Medaka
Match: ENSORLT00000012836.2 (NACHT and WD repeat domain-containing protein 2 [Source:NCBI gene;Acc:101161570])

HSP 1 Score: 64.3142 bits (155), Expect = 5.190e-11
Identity = 36/136 (26.47%), Postives = 65/136 (47.79%), Query Frame = 1 
Query:  490 IRIFLSSTFTDTTLERNIIMKNAYPKLKEYCKKVYGLDFQIVD-------MRWGIRDEATDDHKTTELCLQEIENCKRLSIGPRFVALLGDKYGYRPVPRKIIAQDFENIKSVNSLSKLDLEILNNWYKLDSNTAP 876
            ++I+L S   D+  ER  + ++ +P+ + YC++  GLD +++D        RW   DE T     TE        C+  S GP  +AL+G +YG   +P ++   +F+ +   +  + +    L   Y+ D N  P
Sbjct:   18 VKIYLCSNPEDSRTERQALRQDVFPRFRRYCRRSLGLDVRVIDPFESSDPRRW--PDENTRQRLITE--------CRESSAGPYLLALVGHQYGASCLPAQVQVSEFQLLLQESQRAGISTLELEKAYQRDENIIP 143
[Close]
BLAST of WD_REPEATS_REGION domain-containing protein vs. Planmine SMEST
Match: SMESG000074035.1 (SMESG000074035.1)

HSP 1 Score: 124.79 bits (312), Expect = 9.314e-32
Identity = 58/142 (40.85%), Postives = 92/142 (64.79%), Query Frame = 1 
Query:  490 IRIFLSSTFTDTTLERNIIMKNAYPKLKEYCKKVYGLDFQIVDMRWGIRDEATDDHKTTELCLQEIENCKRLSIGPRFVALLGDKYGYRPVPRKIIAQDFENI-KSVNSLSKLDLEILNNWYKLDSNTAPHMFVSQPISSEI 912
            +RIFLSSTF+D  +ERN+ +K   P L   C   YGL  ++ DMRWG+ D A ++H    LCL+EI+ C++ SIGP FV L+G++YGY+P+P ++ + +FE I K +      + E+++ W++ D N+ P ++   PI + I
Sbjct:   56 VRIFLSSTFSDFKVERNLFIKQVIPSLHSICND-YGLSLRLCDMRWGVTDYAVNEHLVESLCLKEIKMCQKTSIGPFFVLLIGNRYGYQPLPSELPSSEFEMIFKIITDNFPKEAELISKWFQKDVNSEPPVYNLLPIKTFI 196
[Close]
BLAST of WD_REPEATS_REGION domain-containing protein vs. Planmine SMEST
Match: SMESG000074035.1 (SMESG000074035.1)

HSP 1 Score: 125.176 bits (313), Expect = 9.983e-32
Identity = 58/142 (40.85%), Postives = 92/142 (64.79%), Query Frame = 1 
Query:  490 IRIFLSSTFTDTTLERNIIMKNAYPKLKEYCKKVYGLDFQIVDMRWGIRDEATDDHKTTELCLQEIENCKRLSIGPRFVALLGDKYGYRPVPRKIIAQDFENI-KSVNSLSKLDLEILNNWYKLDSNTAPHMFVSQPISSEI 912
            +RIFLSSTF+D  +ERN+ +K   P L   C   YGL  ++ DMRWG+ D A ++H    LCL+EI+ C++ SIGP FV L+G++YGY+P+P ++ + +FE I K +      + E+++ W++ D N+ P ++   PI + I
Sbjct:   56 VRIFLSSTFSDFKVERNLFIKQVIPSLHSICND-YGLSLRLCDMRWGVTDYAVNEHLVESLCLKEIKMCQKTSIGPFFVLLIGNRYGYQPLPSELPSSEFEMIFKIITDNFPKEAELISKWFQKDVNSEPPVYNLLPIKTFI 196
[Close]
BLAST of WD_REPEATS_REGION domain-containing protein vs. Planmine SMEST
Match: SMESG000074035.1 (SMESG000074035.1)

HSP 1 Score: 125.176 bits (313), Expect = 1.012e-31
Identity = 58/142 (40.85%), Postives = 92/142 (64.79%), Query Frame = 1 
Query:  490 IRIFLSSTFTDTTLERNIIMKNAYPKLKEYCKKVYGLDFQIVDMRWGIRDEATDDHKTTELCLQEIENCKRLSIGPRFVALLGDKYGYRPVPRKIIAQDFENI-KSVNSLSKLDLEILNNWYKLDSNTAPHMFVSQPISSEI 912
            +RIFLSSTF+D  +ERN+ +K   P L   C   YGL  ++ DMRWG+ D A ++H    LCL+EI+ C++ SIGP FV L+G++YGY+P+P ++ + +FE I K +      + E+++ W++ D N+ P ++   PI + I
Sbjct:   56 VRIFLSSTFSDFKVERNLFIKQVIPSLHSICND-YGLSLRLCDMRWGVTDYAVNEHLVESLCLKEIKMCQKTSIGPFFVLLIGNRYGYQPLPSELPSSEFEMIFKIITDNFPKEAELISKWFQKDVNSEPPVYNLLPIKTFI 196
[Close]
BLAST of WD_REPEATS_REGION domain-containing protein vs. Planmine SMEST
Match: SMESG000074035.1 (SMESG000074035.1)

HSP 1 Score: 125.176 bits (313), Expect = 1.026e-31
Identity = 58/142 (40.85%), Postives = 92/142 (64.79%), Query Frame = 1 
Query:  490 IRIFLSSTFTDTTLERNIIMKNAYPKLKEYCKKVYGLDFQIVDMRWGIRDEATDDHKTTELCLQEIENCKRLSIGPRFVALLGDKYGYRPVPRKIIAQDFENI-KSVNSLSKLDLEILNNWYKLDSNTAPHMFVSQPISSEI 912
            +RIFLSSTF+D  +ERN+ +K   P L   C   YGL  ++ DMRWG+ D A ++H    LCL+EI+ C++ SIGP FV L+G++YGY+P+P ++ + +FE I K +      + E+++ W++ D N+ P ++   PI + I
Sbjct:   56 VRIFLSSTFSDFKVERNLFIKQVIPSLHSICND-YGLSLRLCDMRWGVTDYAVNEHLVESLCLKEIKMCQKTSIGPFFVLLIGNRYGYQPLPSELPSSEFEMIFKIITDNFPKEAELISKWFQKDVNSEPPVYNLLPIKTFI 196
[Close]
BLAST of WD_REPEATS_REGION domain-containing protein vs. Planmine SMEST
Match: SMESG000074035.1 (SMESG000074035.1)

HSP 1 Score: 125.176 bits (313), Expect = 1.144e-31
Identity = 58/142 (40.85%), Postives = 92/142 (64.79%), Query Frame = 1 
Query:  490 IRIFLSSTFTDTTLERNIIMKNAYPKLKEYCKKVYGLDFQIVDMRWGIRDEATDDHKTTELCLQEIENCKRLSIGPRFVALLGDKYGYRPVPRKIIAQDFENI-KSVNSLSKLDLEILNNWYKLDSNTAPHMFVSQPISSEI 912
            +RIFLSSTF+D  +ERN+ +K   P L   C   YGL  ++ DMRWG+ D A ++H    LCL+EI+ C++ SIGP FV L+G++YGY+P+P ++ + +FE I K +      + E+++ W++ D N+ P ++   PI + I
Sbjct:   56 VRIFLSSTFSDFKVERNLFIKQVIPSLHSICND-YGLSLRLCDMRWGVTDYAVNEHLVESLCLKEIKMCQKTSIGPFFVLLIGNRYGYQPLPSELPSSEFEMIFKIITDNFPKEAELISKWFQKDVNSEPPVYNLLPIKTFI 196
The following BLAST results are available for this feature:
BLAST of WD_REPEATS_REGION domain-containing protein vs. Ensembl Human
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Human e!99)
Total hits: 5
Match NameE-valueIdentityDescription
NWD21.200e-2837.68NACHT and WD repeat domain containing 2 [Source:HG... [more]
NWD13.347e-2541.38NACHT and WD repeat domain containing 1 [Source:HG... [more]
NWD13.713e-2341.74NACHT and WD repeat domain containing 1 [Source:HG... [more]
NWD13.713e-2341.74NACHT and WD repeat domain containing 1 [Source:HG... [more]
NWD13.713e-2341.74NACHT and WD repeat domain containing 1 [Source:HG... [more]
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BLAST of WD_REPEATS_REGION domain-containing protein vs. Ensembl Celegans
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99)
Total hits: 1
Match NameE-valueIdentityDescription
T05C3.22.907e-4947.03pep chromosome:WBcel235:V:5493747:5503010:1 gene:W... [more]
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BLAST of WD_REPEATS_REGION domain-containing protein vs. Ensembl Fly
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99)
Total hits: 1
Match NameE-valueIdentityDescription
CG101855.171e-4752.53gene:FBgn0038397 transcript:FBtr0083235[more]
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BLAST of WD_REPEATS_REGION domain-containing protein vs. Ensembl Zebrafish
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99)
Total hits: 4
Match NameE-valueIdentityDescription
nwd16.417e-3340.26NACHT and WD repeat domain containing 1 [Source:ZF... [more]
nwd23.498e-2737.50NACHT and WD repeat domain containing 2 [Source:ZF... [more]
CU570791.33.990e-1632.09NACHT and WD repeat domain-containing protein 2-li... [more]
si:ch211-212k18.62.416e-1232.11si:ch211-212k18.6 [Source:ZFIN;Acc:ZDB-GENE-130530... [more]
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BLAST of WD_REPEATS_REGION domain-containing protein vs. Ensembl Xenopus
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99)
Total hits: 4
Match NameE-valueIdentityDescription
ppp1r3c.12.156e-3646.46protein phosphatase 1, regulatory (inhibitor) subu... [more]
hsp90ab19.883e-2636.96heat shock protein 90kDa alpha family class B memb... [more]
hs3st51.379e-1140.00heparan sulfate-glucosamine 3-sulfotransferase 5 [... [more]
ENSXETT00000022477.11.251e-1040.26pep primary_assembly:Xenopus_tropicalis_v9.1:KV460... [more]
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BLAST of WD_REPEATS_REGION domain-containing protein vs. Ensembl Mouse
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99)
Total hits: 5
Match NameE-valueIdentityDescription
Nwd15.949e-3543.88NACHT and WD repeat domain containing 1 [Source:MG... [more]
Nwd16.566e-3144.00NACHT and WD repeat domain containing 1 [Source:MG... [more]
Nwd16.597e-3144.00NACHT and WD repeat domain containing 1 [Source:MG... [more]
Nwd22.166e-2836.76NACHT and WD repeat domain containing 2 [Source:MG... [more]
Nwd11.452e-1847.83NACHT and WD repeat domain containing 1 [Source:MG... [more]
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BLAST of WD_REPEATS_REGION domain-containing protein vs. UniProt/SwissProt
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt)
Total hits: 5
Match NameE-valueIdentityDescription
sp|A6H603|NWD1_MOUSE4.615e-3044.00NACHT domain- and WD repeat-containing protein 1 O... [more]
sp|Q9ULI1|NWD2_HUMAN5.763e-2837.68NACHT and WD repeat domain-containing protein 2 OS... [more]
sp|Q6P5U7|NWD2_MOUSE1.515e-2736.76NACHT and WD repeat domain-containing protein 2 OS... [more]
sp|Q149M9|NWD1_HUMAN1.811e-2241.74NACHT domain- and WD repeat-containing protein 1 O... [more]
sp|O08653|TEP1_RAT2.774e-1237.78Telomerase protein component 1 OS=Rattus norvegicu... [more]
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BLAST of WD_REPEATS_REGION domain-containing protein vs. TrEMBL
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL)
Total hits: 5
Match NameE-valueIdentityDescription
A0A4Y2SYV76.504e-5751.27NACHT and WD repeat domain-containing protein 2 OS... [more]
A0A4Y2TZM97.335e-5751.27NACHT and WD repeat domain-containing protein 2 OS... [more]
A0A3M7PE777.212e-5655.97NACHT and WD repeat domain-containing 2 OS=Brachio... [more]
T1J8351.415e-5451.90Uncharacterized protein OS=Strigamia maritima OX=1... [more]
A0A226DA167.021e-5454.09NACHT and WD repeat domain-containing protein 2 OS... [more]
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BLAST of WD_REPEATS_REGION domain-containing protein vs. Ensembl Cavefish
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99)
Total hits: 5
Match NameE-valueIdentityDescription
nwd12.400e-3443.75NACHT and WD repeat domain containing 1 [Source:ZF... [more]
nwd25.162e-2736.76NACHT and WD repeat domain containing 2 [Source:NC... [more]
nwd25.637e-2736.76NACHT and WD repeat domain containing 2 [Source:NC... [more]
nwd25.968e-2736.76NACHT and WD repeat domain containing 2 [Source:NC... [more]
nwd23.681e-1333.02NACHT and WD repeat domain containing 2 [Source:NC... [more]
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BLAST of WD_REPEATS_REGION domain-containing protein vs. Ensembl Sea Lamprey
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99)
Total hits: 0
Match NameE-valueIdentityDescription
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BLAST of WD_REPEATS_REGION domain-containing protein vs. Ensembl Yeast
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46)
Total hits: 0
Match NameE-valueIdentityDescription
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BLAST of WD_REPEATS_REGION domain-containing protein vs. Ensembl Nematostella
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46)
Total hits: 5
Match NameE-valueIdentityDescription
EDO311173.612e-4947.20Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7... [more]
EDO471087.137e-4852.14Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7... [more]
EDO416871.026e-4752.82Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7... [more]
EDO405173.837e-4752.11Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7... [more]
EDO471074.698e-4751.08Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7... [more]
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BLAST of WD_REPEATS_REGION domain-containing protein vs. Ensembl Medaka
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99)
Total hits: 5
Match NameE-valueIdentityDescription
nwd23.030e-2736.76NACHT and WD repeat domain containing 2 [Source:NC... [more]
nwd23.030e-2736.76NACHT and WD repeat domain containing 2 [Source:NC... [more]
nwd23.268e-2736.76NACHT and WD repeat domain containing 2 [Source:NC... [more]
nwd16.623e-2244.12NACHT and WD repeat domain containing 1 [Source:ZF... [more]
ENSORLT00000012836.25.190e-1126.47NACHT and WD repeat domain-containing protein 2 [S... [more]
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BLAST of WD_REPEATS_REGION domain-containing protein vs. Planmine SMEST
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST)
Total hits: 5
Match NameE-valueIdentityDescription
SMESG000074035.19.314e-3240.85SMESG000074035.1[more]
SMESG000074035.19.983e-3240.85SMESG000074035.1[more]
SMESG000074035.11.012e-3140.85SMESG000074035.1[more]
SMESG000074035.11.026e-3140.85SMESG000074035.1[more]
SMESG000074035.11.144e-3140.85SMESG000074035.1[more]
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Sequences
The following sequences are available for this feature:

transcript sequence

>SMED30011092 ID=SMED30011092|Name=WD_REPEATS_REGION domain-containing protein|organism=Schmidtea mediterranea sexual|type=transcript|length=916bp
GATTTTTTTGTCTCCCGTTAAAATTATTGTTGGAAATATTGGGATTTATA
CTTAATAAATGAACCCAACGATGAAACTGTATTTGTAAAATCTTCACTTG
GAAAAATGAGTGTCAATGCATCTATCAAACCAAATAAAGCTCAAGGAGAT
GACAAATATGAAAACAAAAATCATCTGAAAATTATACCGAATTTGAAAAA
GAGCGTGAAGAATAAAACATTAAAAAGTAAAACATCTGTTGATAAAATTA
AAAAACCAAAAAAATCCAAACAAAAAGTTTTACCTGTCACAGATGTATCT
GAAAAATTAAAAAATGAAATTATTTCCTTGGAGAAAAATAATTCTCAATC
AACAAAAAATGAGTCAATAATAAAAACTGAAATAAATAAAAAAAATTGCA
ATATTGAAAATCCCGAAGAATGCGGAATTCTAATAAACAATGTTTATCGA
GGCATCATAAATGAAACGCAAAATTTAAAAAATGGAATTATTCGAATATT
TCTCAGCTCGACATTTACAGATACAACATTAGAAAGAAATATTATTATGA
AAAATGCTTATCCCAAATTAAAAGAATATTGCAAGAAGGTCTACGGATTA
GATTTTCAAATTGTAGATATGAGATGGGGAATACGAGACGAAGCTACAGA
TGATCACAAAACTACAGAACTATGTCTTCAAGAAATTGAAAATTGCAAAC
GTTTATCAATTGGGCCGAGATTTGTGGCTCTGCTTGGCGATAAATATGGA
TACCGACCTGTCCCCCGGAAAATAATTGCTCAAGATTTTGAAAATATAAA
AAGTGTGAATTCATTATCGAAATTAGATTTAGAAATTCTCAATAATTGGT
ATAAACTGGACTCTAACACAGCCCCTCACATGTTTGTCTCGCAACCGATA
AGTTCAGAGATCGGAA
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protein sequence of SMED30011092-orf-1

>SMED30011092-orf-1 ID=SMED30011092-orf-1|Name=SMED30011092-orf-1|organism=Schmidtea mediterranea sexual|type=polypeptide|length=270bp
MSVNASIKPNKAQGDDKYENKNHLKIIPNLKKSVKNKTLKSKTSVDKIKK
PKKSKQKVLPVTDVSEKLKNEIISLEKNNSQSTKNESIIKTEINKKNCNI
ENPEECGILINNVYRGIINETQNLKNGIIRIFLSSTFTDTTLERNIIMKN
AYPKLKEYCKKVYGLDFQIVDMRWGIRDEATDDHKTTELCLQEIENCKRL
SIGPRFVALLGDKYGYRPVPRKIIAQDFENIKSVNSLSKLDLEILNNWYK
LDSNTAPHMFVSQPISSEIG
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Annotated Terms
The following terms have been associated with this transcript:
Vocabulary: INTERPRO
TermDefinition
IPR025139DUF4062
Vocabulary: molecular function
TermDefinition
GO:0000166nucleotide binding
GO:0003674molecular_function
GO:0005524ATP binding
Vocabulary: cellular component
TermDefinition
GO:0005682U5 snRNP
GO:0005737cytoplasm
GO:0005829cytosol
GO:0071011precatalytic spliceosome
GO:0071013catalytic step 2 spliceosome
Vocabulary: biological process
TermDefinition
GO:0008380RNA splicing
InterPro
Analysis Name: Schmidtea mediteranean smed_20140614 Interproscan
Date Performed: 2020-05-01
IPR TermIPR DescriptionSourceSource TermSource DescriptionAlignment
IPR025139Domain of unknown function DUF4062PFAMPF13271DUF4062coord: 130..223
e-value: 1.3E-12
score: 47.9
NoneNo IPR availableMOBIDB_LITEmobidb-litedisorder_predictioncoord: 1..56
NoneNo IPR availableMOBIDB_LITEmobidb-litedisorder_predictioncoord: 12..26
NoneNo IPR availablePANTHERPTHR19871:SF14GH25853Pcoord: 63..267
NoneNo IPR availablePANTHERPTHR19871BETA TRANSDUCIN-RELATED PROTEINcoord: 63..267