Epidermal growth factor receptor kinase substrate 8
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Overview
Neoblast Clusters
Zeng et. al., 2018▻ Overview▻ Neoblast Population▻ Sub-lethal Irradiated Surviving X1 and X2 Cell Population
Overview
Single cell RNA-seq of pluripotent neoblasts and its early progeniesWe isolated X1 neoblasts cells enriched in high piwi-1 expression (Neoblast Population), and profiled ∼7,614 individual cells via scRNA-seq. Unsupervised analyses uncovered 12 distinct classes from 7,088 high-quality cells. We designated these classes Nb1 to Nb12 and ordered them based on high (Nb1) to low (Nb12) piwi-1 expression levels. We further defined groups of genes that best classified the cells parsed into 12 distinct cell clusters to generate a scaled expression heat map of discriminative gene sets for each cluster. Expression of each cluster’s gene signatures was validated using multiplex fluorescence in situ hybridization (FISH) co-stained with piwi-1 and largely confirmed the cell clusters revealed by scRNA-seq.We also tested sub-lethal irradiation exposure. To profile rare pluripotent stem cells (PSCs) and avoid interference from immediate progenitor cells, we determined a time point after sub-lethal irradiation (7 DPI) with minimal piwi-1+ cells, followed by isolation and single-cell RNA-seq of 1,200 individual cells derived from X1 (Piwi-1 high) and X2 (Piwi-1 low) cell populations (Sub-lethal Irradiated Surviving X1 and X2 Cell Population)Explore this single cell expression dataset with our NB Cluster Shiny App
Neoblast Population
Sub-lethal Irradiated Surviving X1 and X2 Cell Population
Embryonic Expression
Davies et. al., 2017
Hover the mouse over a column in the graph to view average RPKM values per sample. Embryonic Stages: Y: yolk. S2-S8: Stages 2-8. C4: asexual adult. SX: virgin, sexually mature adult. back to top Anatomical Expression
PAGE et. al., 2020SMED30011084 has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGEPAGE Curations: 16
Homology
BLAST of Epidermal growth factor receptor kinase substrate 8 vs. Ensembl Human
Match: EPS8L1 (EPS8 like 1 [Source:HGNC Symbol;Acc:HGNC:21295]) HSP 1 Score: 139.043 bits (349), Expect = 1.103e-33 Identity = 142/529 (26.84%), Postives = 237/529 (44.80%), Query Frame = 2
Query: 614 DSKPRNDDISS-RTERNLLLLNYCFDDIEFFLQHLKDQEEAQAILKNTKGKNLNDR------LLEGKAKPSTQNAYLTCIEKIKFSLNLLCKLDGKIKNPDSRQX-----XXXXXXXXXXXGQAYSIYHNGKLSKVKEPLLTEDTVKLLHQCLSKHYHKQWTSWGDNWCK-AREKWAGYKEKYYPEFFNGYQIDLEELMKDGIISPIADIPRRAVSNA---EISHA-IFYNQALPMIAQTDILENTVLSSREEDFCRSVTLRNGKLYRVIATFAASKDEELSMSEGEIIEVIESKPDKNWWLCGNMHGQKGYSPNTLLEPFC--------YIDRSINN---------------FIKSSPESPDYLNVRNIPTVPVSPKRISQIMKDPNSADKVAEANIINEELKKKINTNSNFGGWNSRASFARPGPVVSKKHGQLSINQDSTSEDVQKWLEYKKFSPSDIEKLKIFNGQTLFLLSRDEMVRIVSSEVANRLDSLVKVQKSLSGFGTLSRR----ELDEILTKRKEKVE 2068
D PR D++ + ER + +LN+ FDD+E F+ L+ EA +L++ + + R LL +AKP ++ Y ++KIK++ +LL +L G I +P S +L L + G ++ S V+ P LT D V LL ++ ++ WTS GD+W + E Y PEFF+G++ P+ D RA + ++ H Q+ P +A + + L E S T GK F A ELS+ + +++EV++ + WW + GQ+GY P +L P+ RS+N+ + + P + + ++ + DP+ +K ++ I+NEEL+ ++ S S A PGP + QLS D++ +V+ WL+ K FS ++ L + G LF L ++E+ R VS E R+ S V VQ+SL L + EL+ ++ K+K+KVE
Sbjct: 114 DLGPRGPDLAVLQAEREVDILNHVFDDVESFVSRLQKSAEAARVLEHRERGRRSRRRAAGEGLLTLRAKPPSEAEYTDVLQKIKYAFSLLARLRGNIADPSSPELLHFLFGPLQMIVNTSGGPEFA-------SSVRRPHLTSDAVALLRDNVTPRENELWTSLGDSWTRPGLELSPEEGPPYRPEFFSGWE------------PPVTDPQSRAWEDPVEKQLQHERRRRQQSAPQVA---VNGHRDLEPESEPQLESETA--GKWVLCNYDFQARNSSELSVKQRDVLEVLDDS--RKWWKVRDPAGQEGYVPYNILTPYPGPRLHHSQSPARSLNSTPPPPPAPAPAPPPALARPRWDRPRWDSCDSLNGL------------DPSEKEKFSQMLIVNEELQARLAQG------RSGPSRAVPGPRAPEP--QLSPGSDAS--EVRAWLQAKGFSSGTVDALGVLTGAQLFSLQKEEL-RAVSPEEGARVYSQVTVQRSL-----LEDKEKVSELEAVMEKQKKKVE 588
BLAST of Epidermal growth factor receptor kinase substrate 8 vs. Ensembl Human
Match: EPS8L1 (EPS8 like 1 [Source:HGNC Symbol;Acc:HGNC:21295]) HSP 1 Score: 138.658 bits (348), Expect = 1.961e-33 Identity = 142/529 (26.84%), Postives = 237/529 (44.80%), Query Frame = 2
Query: 614 DSKPRNDDISS-RTERNLLLLNYCFDDIEFFLQHLKDQEEAQAILKNTKGKNLNDR------LLEGKAKPSTQNAYLTCIEKIKFSLNLLCKLDGKIKNPDSRQX-----XXXXXXXXXXXGQAYSIYHNGKLSKVKEPLLTEDTVKLLHQCLSKHYHKQWTSWGDNWCK-AREKWAGYKEKYYPEFFNGYQIDLEELMKDGIISPIADIPRRAVSNA---EISHA-IFYNQALPMIAQTDILENTVLSSREEDFCRSVTLRNGKLYRVIATFAASKDEELSMSEGEIIEVIESKPDKNWWLCGNMHGQKGYSPNTLLEPFC--------YIDRSINN---------------FIKSSPESPDYLNVRNIPTVPVSPKRISQIMKDPNSADKVAEANIINEELKKKINTNSNFGGWNSRASFARPGPVVSKKHGQLSINQDSTSEDVQKWLEYKKFSPSDIEKLKIFNGQTLFLLSRDEMVRIVSSEVANRLDSLVKVQKSLSGFGTLSRR----ELDEILTKRKEKVE 2068
D PR D++ + ER + +LN+ FDD+E F+ L+ EA +L++ + + R LL +AKP ++ Y ++KIK++ +LL +L G I +P S +L L + G ++ S V+ P LT D V LL ++ ++ WTS GD+W + E Y PEFF+G++ P+ D RA + ++ H Q+ P +A + + L E S T GK F A ELS+ + +++EV++ + WW + GQ+GY P +L P+ RS+N+ + + P + + ++ + DP+ +K ++ I+NEEL+ ++ S S A PGP + QLS D++ +V+ WL+ K FS ++ L + G LF L ++E+ R VS E R+ S V VQ+SL L + EL+ ++ K+K+KVE
Sbjct: 177 DLGPRGPDLAVLQAEREVDILNHVFDDVESFVSRLQKSAEAARVLEHRERGRRSRRRAAGEGLLTLRAKPPSEAEYTDVLQKIKYAFSLLARLRGNIADPSSPELLHFLFGPLQMIVNTSGGPEFA-------SSVRRPHLTSDAVALLRDNVTPRENELWTSLGDSWTRPGLELSPEEGPPYRPEFFSGWE------------PPVTDPQSRAWEDPVEKQLQHERRRRQQSAPQVA---VNGHRDLEPESEPQLESET--AGKWVLCNYDFQARNSSELSVKQRDVLEVLDDS--RKWWKVRDPAGQEGYVPYNILTPYPGPRLHHSQSPARSLNSTPPPPPAPAPAPPPALARPRWDRPRWDSCDSLNGL------------DPSEKEKFSQMLIVNEELQARLAQG------RSGPSRAVPGPRAPEP--QLSPGSDAS--EVRAWLQAKGFSSGTVDALGVLTGAQLFSLQKEEL-RAVSPEEGARVYSQVTVQRSL-----LEDKEKVSELEAVMEKQKKKVE 651
BLAST of Epidermal growth factor receptor kinase substrate 8 vs. Ensembl Human
Match: EPS8L1 (EPS8 like 1 [Source:HGNC Symbol;Acc:HGNC:21295]) HSP 1 Score: 138.658 bits (348), Expect = 2.946e-33 Identity = 142/529 (26.84%), Postives = 237/529 (44.80%), Query Frame = 2
Query: 614 DSKPRNDDISS-RTERNLLLLNYCFDDIEFFLQHLKDQEEAQAILKNTKGKNLNDR------LLEGKAKPSTQNAYLTCIEKIKFSLNLLCKLDGKIKNPDSRQX-----XXXXXXXXXXXGQAYSIYHNGKLSKVKEPLLTEDTVKLLHQCLSKHYHKQWTSWGDNWCK-AREKWAGYKEKYYPEFFNGYQIDLEELMKDGIISPIADIPRRAVSNA---EISHA-IFYNQALPMIAQTDILENTVLSSREEDFCRSVTLRNGKLYRVIATFAASKDEELSMSEGEIIEVIESKPDKNWWLCGNMHGQKGYSPNTLLEPFC--------YIDRSINN---------------FIKSSPESPDYLNVRNIPTVPVSPKRISQIMKDPNSADKVAEANIINEELKKKINTNSNFGGWNSRASFARPGPVVSKKHGQLSINQDSTSEDVQKWLEYKKFSPSDIEKLKIFNGQTLFLLSRDEMVRIVSSEVANRLDSLVKVQKSLSGFGTLSRR----ELDEILTKRKEKVE 2068
D PR D++ + ER + +LN+ FDD+E F+ L+ EA +L++ + + R LL +AKP ++ Y ++KIK++ +LL +L G I +P S +L L + G ++ S V+ P LT D V LL ++ ++ WTS GD+W + E Y PEFF+G++ P+ D RA + ++ H Q+ P +A + + L E S T GK F A ELS+ + +++EV++ + WW + GQ+GY P +L P+ RS+N+ + + P + + ++ + DP+ +K ++ I+NEEL+ ++ S S A PGP + QLS D++ +V+ WL+ K FS ++ L + G LF L ++E+ R VS E R+ S V VQ+SL L + EL+ ++ K+K+KVE
Sbjct: 241 DLGPRGPDLAVLQAEREVDILNHVFDDVESFVSRLQKSAEAARVLEHRERGRRSRRRAAGEGLLTLRAKPPSEAEYTDVLQKIKYAFSLLARLRGNIADPSSPELLHFLFGPLQMIVNTSGGPEFA-------SSVRRPHLTSDAVALLRDNVTPRENELWTSLGDSWTRPGLELSPEEGPPYRPEFFSGWE------------PPVTDPQSRAWEDPVEKQLQHERRRRQQSAPQVA---VNGHRDLEPESEPQLESET--AGKWVLCNYDFQARNSSELSVKQRDVLEVLDDS--RKWWKVRDPAGQEGYVPYNILTPYPGPRLHHSQSPARSLNSTPPPPPAPAPAPPPALARPRWDRPRWDSCDSLNGL------------DPSEKEKFSQMLIVNEELQARLAQG------RSGPSRAVPGPRAPEP--QLSPGSDAS--EVRAWLQAKGFSSGTVDALGVLTGAQLFSLQKEEL-RAVSPEEGARVYSQVTVQRSL-----LEDKEKVSELEAVMEKQKKKVE 715
BLAST of Epidermal growth factor receptor kinase substrate 8 vs. Ensembl Human
Match: EPS8L2 (EPS8 like 2 [Source:HGNC Symbol;Acc:HGNC:21296]) HSP 1 Score: 117.857 bits (294), Expect = 1.387e-26 Identity = 131/520 (25.19%), Postives = 223/520 (42.88%), Query Frame = 2
Query: 605 KEYDSKPRNDDISSRTERNLLLLNYCFDDIEFFLQHLKDQEEAQAILKNTKGKNLNDR--------------LLEGKAKPSTQNAYLTCIEKIKFSLNLLCKLDGKIKNPDSRQXXXXXXXXXXXXGQAYSIYHNGKLSKVKEPLLTEDTVKLLHQCLSKHYHKQWTSWGDNWCKAREKWAGYKEK--YYPEFFNGYQIDLE---------ELMKDGIISPIADIPRRAVSNAE----ISHAIFYNQALPMIAQTDILENTVLSSREEDFCRSVTLRNGKLYRVIATFAASKDEELSMSEGEIIEVIESKPDKNWWLCGNMHGQKGYSPNTLL---------EPFCYIDRSINNFIKSSPESPDYLNVRNIPTVPVSPKRISQIMKDPNSADKVAEANIINEELKKKINTNSNFGGWNSRASFARPGPVVSKKHGQLSINQDSTSEDVQKWLEYKKFSPSDIEKLKIFNGQTLFLLSRDEMVRIVSSEVANRLDSLVKVQKSLSGFGTLSRRELDEILTK 2050
+E +PR ++ + E+ +LN DDIE+F+ L+ EA K LN R +L +A+P ++ ++ C +KIK ++NLL KL I+NP + +L+ L L I S + V PLL+ D V L L W S G++W + R +W + Y P+F +G++ ++ E + I ++ + R+++ N++ S ALP + SS T K +++ F A ELS+ + E++EV+E + WW + GQ GY P +L PF +++ + P SP + + P+ P + + Q M + +N+EL +KI+ N RA R V + + +S ++V+ WLE K FSP +E L I G LF L+++E+ ++ E R+ S + +QK+ S EL+E++ K
Sbjct: 238 RESQEEPRAV-LAQKIEKETQILNCALDDIEWFVARLQKAAEA--------FKQLNQRKKGKKKGKKAPAEGVLTLRARPPSEGEFIDCFQKIKLAINLLAKLQKHIQNPSAAELVHFLFGPLDLIVNTCSGPDIAR--SVSCPLLSRDAVDFLRGHLVPKEMSLWESLGESWMRPRSEWPREPQVPLYVPKFHSGWEPPVDVLQEAPWEVEGLASAPIEEVSPVSRQSIRNSQKHSPTSEPTPPGDALPPV-----------SSPHTHRGYQPTPAMAKYVKILYDFTARNANELSVLKDEVLEVLED--GRQWWKLRSRSGQAGYVPCNILGEARPEDAGAPF---EQAGQKYW--GPASPTH---KLPPSFPGNKDELMQHMDE------------VNDELIRKIS--------NIRAQPQRHFRVERSQPVSQPLTYESGPDEVRAWLEAKAFSPRIVENLGILTGPQLFSLNKEELKKVCGEE-GVRVYSQLTMQKAFLE-KQQSGSELEELMNK 703
BLAST of Epidermal growth factor receptor kinase substrate 8 vs. Ensembl Human
Match: EPS8L2 (EPS8 like 2 [Source:HGNC Symbol;Acc:HGNC:21296]) HSP 1 Score: 117.857 bits (294), Expect = 1.387e-26 Identity = 131/520 (25.19%), Postives = 223/520 (42.88%), Query Frame = 2
Query: 605 KEYDSKPRNDDISSRTERNLLLLNYCFDDIEFFLQHLKDQEEAQAILKNTKGKNLNDR--------------LLEGKAKPSTQNAYLTCIEKIKFSLNLLCKLDGKIKNPDSRQXXXXXXXXXXXXGQAYSIYHNGKLSKVKEPLLTEDTVKLLHQCLSKHYHKQWTSWGDNWCKAREKWAGYKEK--YYPEFFNGYQIDLE---------ELMKDGIISPIADIPRRAVSNAE----ISHAIFYNQALPMIAQTDILENTVLSSREEDFCRSVTLRNGKLYRVIATFAASKDEELSMSEGEIIEVIESKPDKNWWLCGNMHGQKGYSPNTLL---------EPFCYIDRSINNFIKSSPESPDYLNVRNIPTVPVSPKRISQIMKDPNSADKVAEANIINEELKKKINTNSNFGGWNSRASFARPGPVVSKKHGQLSINQDSTSEDVQKWLEYKKFSPSDIEKLKIFNGQTLFLLSRDEMVRIVSSEVANRLDSLVKVQKSLSGFGTLSRRELDEILTK 2050
+E +PR ++ + E+ +LN DDIE+F+ L+ EA K LN R +L +A+P ++ ++ C +KIK ++NLL KL I+NP + +L+ L L I S + V PLL+ D V L L W S G++W + R +W + Y P+F +G++ ++ E + I ++ + R+++ N++ S ALP + SS T K +++ F A ELS+ + E++EV+E + WW + GQ GY P +L PF +++ + P SP + + P+ P + + Q M + +N+EL +KI+ N RA R V + + +S ++V+ WLE K FSP +E L I G LF L+++E+ ++ E R+ S + +QK+ S EL+E++ K
Sbjct: 238 RESQEEPRAV-LAQKIEKETQILNCALDDIEWFVARLQKAAEA--------FKQLNQRKKGKKKGKKAPAEGVLTLRARPPSEGEFIDCFQKIKLAINLLAKLQKHIQNPSAAELVHFLFGPLDLIVNTCSGPDIAR--SVSCPLLSRDAVDFLRGHLVPKEMSLWESLGESWMRPRSEWPREPQVPLYVPKFHSGWEPPVDVLQEAPWEVEGLASAPIEEVSPVSRQSIRNSQKHSPTSEPTPPGDALPPV-----------SSPHTHRGYQPTPAMAKYVKILYDFTARNANELSVLKDEVLEVLED--GRQWWKLRSRSGQAGYVPCNILGEARPEDAGAPF---EQAGQKYW--GPASPTH---KLPPSFPGNKDELMQHMDE------------VNDELIRKIS--------NIRAQPQRHFRVERSQPVSQPLTYESGPDEVRAWLEAKAFSPRIVENLGILTGPQLFSLNKEELKKVCGEE-GVRVYSQLTMQKAFLE-KQQSGSELEELMNK 703
BLAST of Epidermal growth factor receptor kinase substrate 8 vs. Ensembl Celegans
Match: eps-8 (EPS (Human endocytosis) related [Source:UniProtKB/TrEMBL;Acc:Q7YTG1]) HSP 1 Score: 72.4034 bits (176), Expect = 9.026e-13 Identity = 92/371 (24.80%), Postives = 150/371 (40.43%), Query Frame = 2
Query: 122 VARHFG-SFMQTGTGKDSTNKALNELCSQIDDGRFRELQCNIEIDRERQVLVIRRWLDQVILEEFKLALITNVASHQQVPDNNYLSNILTFNT-QIKTSSNVLTETHIFQ-----LEDSNLHMVNYLASDIRSAIESATNLNPKNTPIKVLPSNNKRNSYSNEKMNKVKEYDSKPRND-DISSRT----ERNLLLLNYCFDDIEFFLQHLKDQEEAQAIL--KNTKGKNLNDR------------LLEGKAKPSTQNAYLTCIEKIKFSLNLLCKLDGKIKNPDSRQXXXXXXXXXXXXGQA--YSIYHNGKLSKVKEPLLTEDTVKLLHQCLSKHYHKQWTSWGDNWCKAREKWA-GYKEKYYPEFFNGY 1147
V R FG +F G K + + + +Q RFR +E D + ++E+F L LI +H +N+L F + + + TE HIFQ D + NY+ R N +R + + ++ P +D ISS T ER++ LN CFDDIE F+ ++ AQ + +N + + N R +L +A+ ++ ++ ++K K S NLL KL I P++ +L+ L L I +A + + N + V PLL+ + +L+ CL+ H W S G+ W E W Y P F +G+
Sbjct: 41 VGRQFGLTFPADGIRKLKQMEKNSAIWAQPLILRFRHNAVTVEDD------------NGELVEQFPLELIEQPTAHVSNDSRETYNNVLLFVVREDRKRMSTPTEMHIFQCIRVSATDVAEDLKNYVQGQFRRV------------------RNGRRTAAPTHLQAQQQQMPFYPPDDASISSETSEMFERDVNTLNRCFDDIERFVARIQSAALAQREIEQQNHRYRTANRRDKKNQQPPDPNGILFMRAQLPLESEFVDILKKFKLSFNLLAKLKNHIHEPNAPELLHFLFTPLAVILEACHWGLGRNVAPT-VASPLLSLEARELMQNCLTSHESDIWMSLGEAWRTPPEDWTKPLPPPYRPIFNDGF 380 HSP 2 Score: 60.077 bits (144), Expect = 5.229e-9 Identity = 35/93 (37.63%), Postives = 53/93 (56.99%), Query Frame = 2
Query: 1796 QLSINQDSTSEDVQKWLEYKKFSPSDIEKLKIFNGQTLFLLSRDEMVRIVSSEVANRLDSLVKVQKSLSGFGTLSRRELDEILTKRKEKVEIT 2074
+++IN+ S+ EDV +WL+ K FSP I+ L +G LF LS+ + + + L S + VQK SGF T + EL IL R+ VE++
Sbjct: 762 RVAINEKSSPEDVTRWLQEKGFSPRVIDLLDGQDGANLFSLSKLHLQQACGRDEGGYLYSQLLVQKKRSGFRTHTGDELKAILNHRRTHVELS 854 HSP 3 Score: 55.8398 bits (133), Expect = 1.021e-7 Identity = 28/75 (37.33%), Postives = 42/75 (56.00%), Query Frame = 2
Query: 1307 SSREEDFCRSVTLRNGKLYRVIATFAASKDEELSMSEGEIIEVIESKPDKNWWLCGNMHGQKGYSPNTLLE--PF 1525
S R++ F + + GKL V +EL++ +GE +EVI ++NWW C NMH + GY P+T+L PF
Sbjct: 544 SPRQQAFIDDIVAKGGKLAVVTYDRGGQNTKELTVHKGEYLEVIFD--ERNWWECKNMHQRVGYVPHTILSMVPF 616
BLAST of Epidermal growth factor receptor kinase substrate 8 vs. Ensembl Celegans
Match: eps-8 (EPS (Human endocytosis) related [Source:UniProtKB/TrEMBL;Acc:Q7YTG1]) HSP 1 Score: 72.4034 bits (176), Expect = 9.026e-13 Identity = 92/371 (24.80%), Postives = 150/371 (40.43%), Query Frame = 2
Query: 122 VARHFG-SFMQTGTGKDSTNKALNELCSQIDDGRFRELQCNIEIDRERQVLVIRRWLDQVILEEFKLALITNVASHQQVPDNNYLSNILTFNT-QIKTSSNVLTETHIFQ-----LEDSNLHMVNYLASDIRSAIESATNLNPKNTPIKVLPSNNKRNSYSNEKMNKVKEYDSKPRND-DISSRT----ERNLLLLNYCFDDIEFFLQHLKDQEEAQAIL--KNTKGKNLNDR------------LLEGKAKPSTQNAYLTCIEKIKFSLNLLCKLDGKIKNPDSRQXXXXXXXXXXXXGQA--YSIYHNGKLSKVKEPLLTEDTVKLLHQCLSKHYHKQWTSWGDNWCKAREKWA-GYKEKYYPEFFNGY 1147
V R FG +F G K + + + +Q RFR +E D + ++E+F L LI +H +N+L F + + + TE HIFQ D + NY+ R N +R + + ++ P +D ISS T ER++ LN CFDDIE F+ ++ AQ + +N + + N R +L +A+ ++ ++ ++K K S NLL KL I P++ +L+ L L I +A + + N + V PLL+ + +L+ CL+ H W S G+ W E W Y P F +G+
Sbjct: 41 VGRQFGLTFPADGIRKLKQMEKNSAIWAQPLILRFRHNAVTVEDD------------NGELVEQFPLELIEQPTAHVSNDSRETYNNVLLFVVREDRKRMSTPTEMHIFQCIRVSATDVAEDLKNYVQGQFRRV------------------RNGRRTAAPTHLQAQQQQMPFYPPDDASISSETSEMFERDVNTLNRCFDDIERFVARIQSAALAQREIEQQNHRYRTANRRDKKNQQPPDPNGILFMRAQLPLESEFVDILKKFKLSFNLLAKLKNHIHEPNAPELLHFLFTPLAVILEACHWGLGRNVAPT-VASPLLSLEARELMQNCLTSHESDIWMSLGEAWRTPPEDWTKPLPPPYRPIFNDGF 380 HSP 2 Score: 60.077 bits (144), Expect = 5.229e-9 Identity = 35/93 (37.63%), Postives = 53/93 (56.99%), Query Frame = 2
Query: 1796 QLSINQDSTSEDVQKWLEYKKFSPSDIEKLKIFNGQTLFLLSRDEMVRIVSSEVANRLDSLVKVQKSLSGFGTLSRRELDEILTKRKEKVEIT 2074
+++IN+ S+ EDV +WL+ K FSP I+ L +G LF LS+ + + + L S + VQK SGF T + EL IL R+ VE++
Sbjct: 762 RVAINEKSSPEDVTRWLQEKGFSPRVIDLLDGQDGANLFSLSKLHLQQACGRDEGGYLYSQLLVQKKRSGFRTHTGDELKAILNHRRTHVELS 854 HSP 3 Score: 55.8398 bits (133), Expect = 1.021e-7 Identity = 28/75 (37.33%), Postives = 42/75 (56.00%), Query Frame = 2
Query: 1307 SSREEDFCRSVTLRNGKLYRVIATFAASKDEELSMSEGEIIEVIESKPDKNWWLCGNMHGQKGYSPNTLLE--PF 1525
S R++ F + + GKL V +EL++ +GE +EVI ++NWW C NMH + GY P+T+L PF
Sbjct: 544 SPRQQAFIDDIVAKGGKLAVVTYDRGGQNTKELTVHKGEYLEVIFD--ERNWWECKNMHQRVGYVPHTILSMVPF 616
BLAST of Epidermal growth factor receptor kinase substrate 8 vs. Ensembl Celegans
Match: eps-8 (EPS (Human endocytosis) related [Source:UniProtKB/TrEMBL;Acc:Q7YTG1]) HSP 1 Score: 72.4034 bits (176), Expect = 9.026e-13 Identity = 92/371 (24.80%), Postives = 150/371 (40.43%), Query Frame = 2
Query: 122 VARHFG-SFMQTGTGKDSTNKALNELCSQIDDGRFRELQCNIEIDRERQVLVIRRWLDQVILEEFKLALITNVASHQQVPDNNYLSNILTFNT-QIKTSSNVLTETHIFQ-----LEDSNLHMVNYLASDIRSAIESATNLNPKNTPIKVLPSNNKRNSYSNEKMNKVKEYDSKPRND-DISSRT----ERNLLLLNYCFDDIEFFLQHLKDQEEAQAIL--KNTKGKNLNDR------------LLEGKAKPSTQNAYLTCIEKIKFSLNLLCKLDGKIKNPDSRQXXXXXXXXXXXXGQA--YSIYHNGKLSKVKEPLLTEDTVKLLHQCLSKHYHKQWTSWGDNWCKAREKWA-GYKEKYYPEFFNGY 1147
V R FG +F G K + + + +Q RFR +E D + ++E+F L LI +H +N+L F + + + TE HIFQ D + NY+ R N +R + + ++ P +D ISS T ER++ LN CFDDIE F+ ++ AQ + +N + + N R +L +A+ ++ ++ ++K K S NLL KL I P++ +L+ L L I +A + + N + V PLL+ + +L+ CL+ H W S G+ W E W Y P F +G+
Sbjct: 41 VGRQFGLTFPADGIRKLKQMEKNSAIWAQPLILRFRHNAVTVEDD------------NGELVEQFPLELIEQPTAHVSNDSRETYNNVLLFVVREDRKRMSTPTEMHIFQCIRVSATDVAEDLKNYVQGQFRRV------------------RNGRRTAAPTHLQAQQQQMPFYPPDDASISSETSEMFERDVNTLNRCFDDIERFVARIQSAALAQREIEQQNHRYRTANRRDKKNQQPPDPNGILFMRAQLPLESEFVDILKKFKLSFNLLAKLKNHIHEPNAPELLHFLFTPLAVILEACHWGLGRNVAPT-VASPLLSLEARELMQNCLTSHESDIWMSLGEAWRTPPEDWTKPLPPPYRPIFNDGF 380 HSP 2 Score: 60.077 bits (144), Expect = 5.229e-9 Identity = 35/93 (37.63%), Postives = 53/93 (56.99%), Query Frame = 2
Query: 1796 QLSINQDSTSEDVQKWLEYKKFSPSDIEKLKIFNGQTLFLLSRDEMVRIVSSEVANRLDSLVKVQKSLSGFGTLSRRELDEILTKRKEKVEIT 2074
+++IN+ S+ EDV +WL+ K FSP I+ L +G LF LS+ + + + L S + VQK SGF T + EL IL R+ VE++
Sbjct: 762 RVAINEKSSPEDVTRWLQEKGFSPRVIDLLDGQDGANLFSLSKLHLQQACGRDEGGYLYSQLLVQKKRSGFRTHTGDELKAILNHRRTHVELS 854 HSP 3 Score: 55.8398 bits (133), Expect = 1.021e-7 Identity = 28/75 (37.33%), Postives = 42/75 (56.00%), Query Frame = 2
Query: 1307 SSREEDFCRSVTLRNGKLYRVIATFAASKDEELSMSEGEIIEVIESKPDKNWWLCGNMHGQKGYSPNTLLE--PF 1525
S R++ F + + GKL V +EL++ +GE +EVI ++NWW C NMH + GY P+T+L PF
Sbjct: 544 SPRQQAFIDDIVAKGGKLAVVTYDRGGQNTKELTVHKGEYLEVIFD--ERNWWECKNMHQRVGYVPHTILSMVPF 616
BLAST of Epidermal growth factor receptor kinase substrate 8 vs. Ensembl Celegans
Match: eps-8 (EPS (Human endocytosis) related [Source:UniProtKB/TrEMBL;Acc:Q7YTG1]) HSP 1 Score: 72.4034 bits (176), Expect = 9.026e-13 Identity = 92/371 (24.80%), Postives = 150/371 (40.43%), Query Frame = 2
Query: 122 VARHFG-SFMQTGTGKDSTNKALNELCSQIDDGRFRELQCNIEIDRERQVLVIRRWLDQVILEEFKLALITNVASHQQVPDNNYLSNILTFNT-QIKTSSNVLTETHIFQ-----LEDSNLHMVNYLASDIRSAIESATNLNPKNTPIKVLPSNNKRNSYSNEKMNKVKEYDSKPRND-DISSRT----ERNLLLLNYCFDDIEFFLQHLKDQEEAQAIL--KNTKGKNLNDR------------LLEGKAKPSTQNAYLTCIEKIKFSLNLLCKLDGKIKNPDSRQXXXXXXXXXXXXGQA--YSIYHNGKLSKVKEPLLTEDTVKLLHQCLSKHYHKQWTSWGDNWCKAREKWA-GYKEKYYPEFFNGY 1147
V R FG +F G K + + + +Q RFR +E D + ++E+F L LI +H +N+L F + + + TE HIFQ D + NY+ R N +R + + ++ P +D ISS T ER++ LN CFDDIE F+ ++ AQ + +N + + N R +L +A+ ++ ++ ++K K S NLL KL I P++ +L+ L L I +A + + N + V PLL+ + +L+ CL+ H W S G+ W E W Y P F +G+
Sbjct: 41 VGRQFGLTFPADGIRKLKQMEKNSAIWAQPLILRFRHNAVTVEDD------------NGELVEQFPLELIEQPTAHVSNDSRETYNNVLLFVVREDRKRMSTPTEMHIFQCIRVSATDVAEDLKNYVQGQFRRV------------------RNGRRTAAPTHLQAQQQQMPFYPPDDASISSETSEMFERDVNTLNRCFDDIERFVARIQSAALAQREIEQQNHRYRTANRRDKKNQQPPDPNGILFMRAQLPLESEFVDILKKFKLSFNLLAKLKNHIHEPNAPELLHFLFTPLAVILEACHWGLGRNVAPT-VASPLLSLEARELMQNCLTSHESDIWMSLGEAWRTPPEDWTKPLPPPYRPIFNDGF 380 HSP 2 Score: 60.077 bits (144), Expect = 5.229e-9 Identity = 35/93 (37.63%), Postives = 53/93 (56.99%), Query Frame = 2
Query: 1796 QLSINQDSTSEDVQKWLEYKKFSPSDIEKLKIFNGQTLFLLSRDEMVRIVSSEVANRLDSLVKVQKSLSGFGTLSRRELDEILTKRKEKVEIT 2074
+++IN+ S+ EDV +WL+ K FSP I+ L +G LF LS+ + + + L S + VQK SGF T + EL IL R+ VE++
Sbjct: 762 RVAINEKSSPEDVTRWLQEKGFSPRVIDLLDGQDGANLFSLSKLHLQQACGRDEGGYLYSQLLVQKKRSGFRTHTGDELKAILNHRRTHVELS 854 HSP 3 Score: 55.8398 bits (133), Expect = 1.021e-7 Identity = 28/75 (37.33%), Postives = 42/75 (56.00%), Query Frame = 2
Query: 1307 SSREEDFCRSVTLRNGKLYRVIATFAASKDEELSMSEGEIIEVIESKPDKNWWLCGNMHGQKGYSPNTLLE--PF 1525
S R++ F + + GKL V +EL++ +GE +EVI ++NWW C NMH + GY P+T+L PF
Sbjct: 544 SPRQQAFIDDIVAKGGKLAVVTYDRGGQNTKELTVHKGEYLEVIFD--ERNWWECKNMHQRVGYVPHTILSMVPF 616
BLAST of Epidermal growth factor receptor kinase substrate 8 vs. Ensembl Celegans
Match: eps-8 (EPS (Human endocytosis) related [Source:UniProtKB/TrEMBL;Acc:Q7YTG1]) HSP 1 Score: 72.4034 bits (176), Expect = 9.026e-13 Identity = 92/371 (24.80%), Postives = 150/371 (40.43%), Query Frame = 2
Query: 122 VARHFG-SFMQTGTGKDSTNKALNELCSQIDDGRFRELQCNIEIDRERQVLVIRRWLDQVILEEFKLALITNVASHQQVPDNNYLSNILTFNT-QIKTSSNVLTETHIFQ-----LEDSNLHMVNYLASDIRSAIESATNLNPKNTPIKVLPSNNKRNSYSNEKMNKVKEYDSKPRND-DISSRT----ERNLLLLNYCFDDIEFFLQHLKDQEEAQAIL--KNTKGKNLNDR------------LLEGKAKPSTQNAYLTCIEKIKFSLNLLCKLDGKIKNPDSRQXXXXXXXXXXXXGQA--YSIYHNGKLSKVKEPLLTEDTVKLLHQCLSKHYHKQWTSWGDNWCKAREKWA-GYKEKYYPEFFNGY 1147
V R FG +F G K + + + +Q RFR +E D + ++E+F L LI +H +N+L F + + + TE HIFQ D + NY+ R N +R + + ++ P +D ISS T ER++ LN CFDDIE F+ ++ AQ + +N + + N R +L +A+ ++ ++ ++K K S NLL KL I P++ +L+ L L I +A + + N + V PLL+ + +L+ CL+ H W S G+ W E W Y P F +G+
Sbjct: 41 VGRQFGLTFPADGIRKLKQMEKNSAIWAQPLILRFRHNAVTVEDD------------NGELVEQFPLELIEQPTAHVSNDSRETYNNVLLFVVREDRKRMSTPTEMHIFQCIRVSATDVAEDLKNYVQGQFRRV------------------RNGRRTAAPTHLQAQQQQMPFYPPDDASISSETSEMFERDVNTLNRCFDDIERFVARIQSAALAQREIEQQNHRYRTANRRDKKNQQPPDPNGILFMRAQLPLESEFVDILKKFKLSFNLLAKLKNHIHEPNAPELLHFLFTPLAVILEACHWGLGRNVAPT-VASPLLSLEARELMQNCLTSHESDIWMSLGEAWRTPPEDWTKPLPPPYRPIFNDGF 380 HSP 2 Score: 60.077 bits (144), Expect = 5.229e-9 Identity = 35/93 (37.63%), Postives = 53/93 (56.99%), Query Frame = 2
Query: 1796 QLSINQDSTSEDVQKWLEYKKFSPSDIEKLKIFNGQTLFLLSRDEMVRIVSSEVANRLDSLVKVQKSLSGFGTLSRRELDEILTKRKEKVEIT 2074
+++IN+ S+ EDV +WL+ K FSP I+ L +G LF LS+ + + + L S + VQK SGF T + EL IL R+ VE++
Sbjct: 762 RVAINEKSSPEDVTRWLQEKGFSPRVIDLLDGQDGANLFSLSKLHLQQACGRDEGGYLYSQLLVQKKRSGFRTHTGDELKAILNHRRTHVELS 854 HSP 3 Score: 55.8398 bits (133), Expect = 1.021e-7 Identity = 28/75 (37.33%), Postives = 42/75 (56.00%), Query Frame = 2
Query: 1307 SSREEDFCRSVTLRNGKLYRVIATFAASKDEELSMSEGEIIEVIESKPDKNWWLCGNMHGQKGYSPNTLLE--PF 1525
S R++ F + + GKL V +EL++ +GE +EVI ++NWW C NMH + GY P+T+L PF
Sbjct: 544 SPRQQAFIDDIVAKGGKLAVVTYDRGGQNTKELTVHKGEYLEVIFD--ERNWWECKNMHQRVGYVPHTILSMVPF 616
BLAST of Epidermal growth factor receptor kinase substrate 8 vs. Ensembl Fly
Match: CG8907 (gene:FBgn0038466 transcript:FBtr0305271) HSP 1 Score: 99.3673 bits (246), Expect = 4.647e-21 Identity = 99/416 (23.80%), Postives = 189/416 (45.43%), Query Frame = 2
Query: 302 LEEFKLALITNVASHQQVPDNNYLSNILTFNTQIKTSSNVLTETHIFQLEDSNLHMVNYLASDIRSAIE-SATNLNPKNTPIKVLPSNNKRNSYSNEKMNKVKEYDSKP--RNDDISSRTERNLLLLNYCFDDIEFFLQHLKDQEEAQAILKNTKGKN--LNDRLLEGKAKPSTQNAYLTCIEKIKFSLNLLCKLDGKIKNPDSRQXXXXXXXXXXXXGQAYSIYHNGKLSK-VKEPLLTEDTVKLLHQCLSKHYHKQWTSWGDNWCKAREKWAGYKEKYYPEFFNGYQIDLEELMKDGIISPIADIPRRAVSNAEISHAIFYNQALPMIAQTDILENTVLSSREEDFCRSVTLRNGKLYRVIATFAASKDEELSMSEGEIIEVIESKPDKNWWLCGNMHGQKGYSPNTLLEPFCY 1531
+E F +LIT + +NIL F+ + N TE HIFQ+ D + + L D+++ + + ++ TPI + +N + ++ +N +TER++ ++N+CF+DIE F+ L EA LK K ++ + LL +++P ++ + + K K +L +L + P + + + I + IY + L + V PLL +T+ L+ L + + W S G NW ++++ +K Y+P F++ + D + D + +A +++ + + + + + L N SR E RN K+ V +A+ D+EL +++GE +E+I+ +NWW N +G GY P+T+L P+ +
Sbjct: 106 IENFPGSLITEPTAFISDHPQESFNNILIFSVPGISLGN--TEMHIFQVADVSSVL---LVEDLKTLSKGTPVTVDRNKTPILLPKPERPQNQQAKDQYGIAAAVAGIAAEKNAIDKEQTERDVQVINHCFEDIERFMARLHYAAEALNELKLRKEQHNPHGEGLLVLRSRPPIESEFHDILAKAKLALIYSVRLQNQFTKP-ADPVHNVFISLKSIVTVCNDIYVDAGLPQAVLNPLLRRETIAFLNGTLDSNEMQLWQSLGPNWTVPKDQFKDHKSSYHPIFYDDWSPD---WVVDEEVPYLAPALKKSTTPSPVPVPMPPSPG---------LGNRTWLSRLES-------RNVKIAEVTFNKSATNDKELKVTKGEYLEIIDD--SRNWWKARNSYGNIGYVPHTVLTPYNF 494
BLAST of Epidermal growth factor receptor kinase substrate 8 vs. Ensembl Fly
Match: CG8907 (gene:FBgn0038466 transcript:FBtr0083372) HSP 1 Score: 98.9821 bits (245), Expect = 4.761e-21 Identity = 99/416 (23.80%), Postives = 191/416 (45.91%), Query Frame = 2
Query: 302 LEEFKLALITNVASHQQVPDNNYLSNILTFNTQIKTSSNVLTETHIFQLEDSNLHMVNYLASDIRSAIE-SATNLNPKNTPIKVLPSNNKRNSYSNEK--MNKVKEYDSKPRNDDISSRTERNLLLLNYCFDDIEFFLQHLKDQEEAQAILKNTKGKN--LNDRLLEGKAKPSTQNAYLTCIEKIKFSLNLLCKLDGKIKNPDSRQXXXXXXXXXXXXGQAYSIYHNGKLSK-VKEPLLTEDTVKLLHQCLSKHYHKQWTSWGDNWCKAREKWAGYKEKYYPEFFNGYQIDLEELMKDGIISPIADIPRRAVSNAEISHAIFYNQALPMIAQTDILENTVLSSREEDFCRSVTLRNGKLYRVIATFAASKDEELSMSEGEIIEVIESKPDKNWWLCGNMHGQKGYSPNTLLEPFCY 1531
+E F +LIT + +NIL F+ + N TE HIFQ+ D + + L D+++ + + ++ TPI + +N + ++ + + +N +TER++ ++N+CF+DIE F+ L EA LK K ++ + LL +++P ++ + + K K +L +L + P + + + I + IY + L + V PLL +T+ L+ L + + W S G NW ++++ +K Y+P F++ + D + D + +A +++ + + + + + L N SR E RN K+ V +A+ D+EL +++GE +E+I+ +NWW N +G GY P+T+L P+ +
Sbjct: 86 IENFPGSLITEPTAFISDHPQESFNNILIFSVPGISLGN--TEMHIFQVADVSSVL---LVEDLKTLSKGTPVTVDRNKTPILLPKPERPQNQQAKDQYGIAAAVAGIAAEKNAIDKEQTERDVQVINHCFEDIERFMARLHYAAEALNELKLRKEQHNPHGEGLLVLRSRPPIESEFHDILAKAKLALIYSVRLQNQFTKP-ADPVHNVFISLKSIVTVCNDIYVDAGLPQAVLNPLLRRETIAFLNGTLDSNEMQLWQSLGPNWTVPKDQFKDHKSSYHPIFYDDWSPD---WVVDEEVPYLAPALKKSTTPSPVPVPMPPSPG---------LGNRTWLSRLES-------RNVKIAEVTFNKSATNDKELKVTKGEYLEIIDD--SRNWWKARNSYGNIGYVPHTVLTPYNF 474
BLAST of Epidermal growth factor receptor kinase substrate 8 vs. Ensembl Fly
Match: aru (gene:FBgn0029095 transcript:FBtr0078033) HSP 1 Score: 84.3445 bits (207), Expect = 1.958e-16 Identity = 56/180 (31.11%), Postives = 92/180 (51.11%), Query Frame = 2
Query: 641 SSRTERNLLLLNYCFDDIEFFLQHLKDQEEAQAILKNTKGK------NLNDRLLEGKAKPSTQNAYLTCIEKIKFSLNLLCKLDGKIKNPDSRQXXXXXXXXXXXXGQAYS-IYHNGKL-SKVKEPLLTEDTVKLLHQCLSKHYHKQWTSWGDNWCKAREKWAGYKEKYYPEFFNGYQID 1156
S + ER++ +LN+CFDDIE F+ L+ A L+ + + + LL + +P + ++ K K S NLL KL I +P++ +L+ L L I +A S Y+ +L ++V PLLT + + LL C++ + W S GD W R++W Y+P F +G+ D
Sbjct: 328 SEKYERDVAVLNHCFDDIEKFIARLQHAAAASRELERRRRNRKSKKRDPGEGLLTLRTRPPHEKEFVDIFAKFKLSFNLLAKLKAHIHDPNAPELVHFLFTPLALIVEASSDTYYESQLPARVVNPLLTREAINLLINCVTSKETELWRSLGDAWVIPRDQWKDDVGSYHPVFLDGWSPD 507
BLAST of Epidermal growth factor receptor kinase substrate 8 vs. Ensembl Fly
Match: aru (gene:FBgn0029095 transcript:FBtr0078032) HSP 1 Score: 84.3445 bits (207), Expect = 2.188e-16 Identity = 56/180 (31.11%), Postives = 92/180 (51.11%), Query Frame = 2
Query: 641 SSRTERNLLLLNYCFDDIEFFLQHLKDQEEAQAILKNTKGK------NLNDRLLEGKAKPSTQNAYLTCIEKIKFSLNLLCKLDGKIKNPDSRQXXXXXXXXXXXXGQAYS-IYHNGKL-SKVKEPLLTEDTVKLLHQCLSKHYHKQWTSWGDNWCKAREKWAGYKEKYYPEFFNGYQID 1156
S + ER++ +LN+CFDDIE F+ L+ A L+ + + + LL + +P + ++ K K S NLL KL I +P++ +L+ L L I +A S Y+ +L ++V PLLT + + LL C++ + W S GD W R++W Y+P F +G+ D
Sbjct: 301 SEKYERDVAVLNHCFDDIEKFIARLQHAAAASRELERRRRNRKSKKRDPGEGLLTLRTRPPHEKEFVDIFAKFKLSFNLLAKLKAHIHDPNAPELVHFLFTPLALIVEASSDTYYESQLPARVVNPLLTREAINLLINCVTSKETELWRSLGDAWVIPRDQWKDDVGSYHPVFLDGWSPD 480
BLAST of Epidermal growth factor receptor kinase substrate 8 vs. Ensembl Fly
Match: aru (gene:FBgn0029095 transcript:FBtr0078031) HSP 1 Score: 84.3445 bits (207), Expect = 2.188e-16 Identity = 56/180 (31.11%), Postives = 92/180 (51.11%), Query Frame = 2
Query: 641 SSRTERNLLLLNYCFDDIEFFLQHLKDQEEAQAILKNTKGK------NLNDRLLEGKAKPSTQNAYLTCIEKIKFSLNLLCKLDGKIKNPDSRQXXXXXXXXXXXXGQAYS-IYHNGKL-SKVKEPLLTEDTVKLLHQCLSKHYHKQWTSWGDNWCKAREKWAGYKEKYYPEFFNGYQID 1156
S + ER++ +LN+CFDDIE F+ L+ A L+ + + + LL + +P + ++ K K S NLL KL I +P++ +L+ L L I +A S Y+ +L ++V PLLT + + LL C++ + W S GD W R++W Y+P F +G+ D
Sbjct: 301 SEKYERDVAVLNHCFDDIEKFIARLQHAAAASRELERRRRNRKSKKRDPGEGLLTLRTRPPHEKEFVDIFAKFKLSFNLLAKLKAHIHDPNAPELVHFLFTPLALIVEASSDTYYESQLPARVVNPLLTREAINLLINCVTSKETELWRSLGDAWVIPRDQWKDDVGSYHPVFLDGWSPD 480
BLAST of Epidermal growth factor receptor kinase substrate 8 vs. Ensembl Zebrafish
Match: eps8l1b (eps8 like 1b [Source:ZFIN;Acc:ZDB-GENE-050506-143]) HSP 1 Score: 156.762 bits (395), Expect = 2.626e-40 Identity = 129/482 (26.76%), Postives = 222/482 (46.06%), Query Frame = 2
Query: 668 LLNYCFDDIEFFLQHLKDQEEAQAILKN-------TKGKNLNDRLLEGKAKPSTQNAYLTCIEKIKFSLNLLCKLDGKIKNPDSRQXXXXXXXXXXXXGQAYSIYHNGKLSKVKEPLLTEDTVKLLHQCLSKHYHKQWTSWGDNWCKAREKWAGYKEKYYPEFFNGYQIDLEELMKDGIISPIADIPRR--AVSNAEISHAIFYNQALPMIAQTDILENTVLSSREEDFCRSVTLRNGKLYRVIATFAASKDEELSMSEGEIIEVIESKPDKNWWLCGNMHGQKGYSPNTLLEPFCYIDRSINNFIKSSPESPDYLNV----RNIPTVPVSPKRISQIMKD-PNSADKVAEANIINEELKKKINTNSNFGGWNSRASFARPGPVVSKKHGQLSINQDSTSEDVQKWLEYKKFSPSDIEKLKIFNGQTLFLLSRDEMVRIVSSEVANRLDSLVKVQKSLSGFGTLSRRELDEILTKRKEKVEI 2071
+LN+CFDDIE F+ L+ EAQ IL + K+ ++ LL KAKP ++ ++ +K K+ L LL +L I NP + +L+ + + L + +A G + V P +TE V LL L+ + W S G NW R Y +F +G++ + G I PI + ++ E++ A + + +D + +V NG+++R F A + ELS+ +GE +E IES K WW C N + G+ P +LEP +ID + N P +P N + + P + + S I+ P DKV + +N+EL +++ + N + R R ++ +S +V+ WL K FS ++ L++ NG LF L+++E+ ++ E A R+ S + VQ++ + EL+ ++ K+K KV++
Sbjct: 52 ILNHCFDDIEAFIGKLQQSAEAQIILDQRSKKKKKNQKKSADEDLLTAKAKPPSEREFIDTFQKFKYCLGLLARLKPAISNPSAEELVHHVFKPLDMMVKATG--GPGFAASVSSPAMTEGAVNLLKNNLTTQENALWLSLGPNWTHQRSALRSPVAPYTLQFQDGWKPQGSDAA--GWIDPIESEHKHDAEIAKVELTPAPASERHASPVQTSDQPDGSV---------------NGRIFRCSYDFVARNNSELSVLQGETLEAIESS--KRWWKCRNKFDEVGFVPFNILEPITHIDNPVQNRTPKPPAAPPMYNTLPSSSAVSSEPGAARPRSMIIPSGPEDTDKVMQ---VNDELLQRLTSGKNL---SPRLVIHR------SADTSAPLDYNSPPAEVENWLRKKGFSEPTVQCLRVLNGAQLFSLNKEELRAVIPEEGA-RVYSQLTVQRAQIEDAHRA-SELETVMEKQKMKVDL 498
BLAST of Epidermal growth factor receptor kinase substrate 8 vs. Ensembl Zebrafish
Match: eps8l1a (eps8 like 1a [Source:ZFIN;Acc:ZDB-GENE-050306-14]) HSP 1 Score: 155.992 bits (393), Expect = 5.511e-40 Identity = 148/550 (26.91%), Postives = 244/550 (44.36%), Query Frame = 2
Query: 509 SATNLNPKNTP--IKVLPSNNKRNSYSNEKMNKVKEYDSKPRNDDISSRTERNLLLLNYCFDDIEFFLQHLKDQEEAQAILKNTKGKNL--------------NDRLLEGKAKPSTQNAYLTCIEKIKFSLNLLCKLDGKIKNPDSRQXXXXXXXXXXXXGQAYSIYHNGKL-SKVKEPLLTEDTVKLLHQCLSKHYHKQWTSWGDNWCKAREKWAGYKEKYYPEFFNGYQIDLEELMKDGIISPIADIPRRAVSNAEISHAIFYNQALPMIAQTDILENTVLSSREE-DFCRSVTLRNGKLYRVIATFAASKDEELSMSEGEIIEVIESKPDKNWWLCGNMHGQKGYSPNTLLEPFCYIDRSINNFI-----KSSPESPDYLNVRNIPTVPVSPKRISQIMKDPNS------ADKVAEANIINEELKKKINTNSNFGGWNSRASFARPGPVVSKKHGQLSINQDSTSEDVQKWLEYKKFSPSDIEKLKIFNGQTLFLLSRDEMVRIVSSEVANRLDSLVKVQKSLSGFGTLSRRELDEILTKRKEKVEI 2071
+A + P++ P IKVLP+N S ++ + D N + +R + L+N+CF D+E F+ L+ EA+ I + K +D K P ++ ++ +KIK+S LL +L KI P S +L+ + L + + KL S + P LT + LL L++ WTS G NW + + +Y P F +G+Q + D PI D E+ H ++AL I +++ L+ +E D + ++YR F A ELS+ GE +EV+ES K WW C N +GQ G+ P+ +LEP + + N + +P SP +R +PK S + DP AD + ++N+EL +++ N RA+ RP + + ++ S +VQ+WL+ K F+ ++ L + NG LF L+++E+ R V E R+ S + VQKSL EL+ I+ K+K K ++
Sbjct: 2 AAPAVVPRSRPKSIKVLPTNGTAADLSPIGVHAMNGGDRVKTNTHLI-YAQREVELVNHCFADVEHFMARLQQTAEAKNIQEQLKRSKKKSRKKNKTKKNKKEDDEPTPQKVTPPSEQEFVDIFQKIKYSFCLLDRLKMKISEPSSEELLHHVFVPLQLMVKTTG---GPKLASSISSPALTSGAISLLQHNLNEQEKTLWTSLGPNWTLPYSQLSETVPQYTPVFLDGWQ----PIAVDANGQPIED-------PIEVQHK---HEAL--IQTQQVIDQARLTVHQENDGMEPLPPNEERMYRCSYDFVARNSSELSVLHGESLEVLES--SKRWWKCKNSYGQTGFVPHNILEPINHAEVDSTNVVMRNQSTKAPISP----LRGGRMSYAAPKSESAVHPDPRPLSMPSFADDGEKVVLMNDELIQRLA--------NGRAASVRPMVINKANETTVPLDYHSPQAEVQEWLKAKGFNNITVQSLGVLNGAQLFSLNKEEL-RAVCPEEGARVYSQITVQKSLLE-DVRKATELEAIMKKQKMKADL 515
BLAST of Epidermal growth factor receptor kinase substrate 8 vs. Ensembl Zebrafish
Match: eps8l1a (eps8 like 1a [Source:ZFIN;Acc:ZDB-GENE-050306-14]) HSP 1 Score: 155.221 bits (391), Expect = 1.097e-39 Identity = 148/550 (26.91%), Postives = 242/550 (44.00%), Query Frame = 2
Query: 509 SATNLNPKNTP--IKVLPSNNKRNSYSNEKMNKVKEYDSKPRNDDISSRTERNLLLLNYCFDDIEFFLQHLKDQEEAQAILKNTKGKNL--------------NDRLLEGKAKPSTQNAYLTCIEKIKFSLNLLCKLDGKIKNPDSRQXXXXXXXXXXXXGQAYSIYHNGKL-SKVKEPLLTEDTVKLLHQCLSKHYHKQWTSWGDNWCKAREKWAGYKEKYYPEFFNGYQIDLEELMKDGIISPIADIPRRAVSNAEISHAIFYNQALPMIAQTDILENTVLSSREE-DFCRSVTLRNGKLYRVIATFAASKDEELSMSEGEIIEVIESKPDKNWWLCGNMHGQKGYSPNTLLEPFCYIDRSINNFI-----KSSPESPDYLNVRNIPTVPVSPKRISQIMKDPNS------ADKVAEANIINEELKKKINTNSNFGGWNSRASFARPGPVVSKKHGQLSINQDSTSEDVQKWLEYKKFSPSDIEKLKIFNGQTLFLLSRDEMVRIVSSEVANRLDSLVKVQKSLSGFGTLSRRELDEILTKRKEKVEI 2071
+A + P++ P IKVLP+N S ++ + D N + +R + L+N+CF D+E F+ L+ EA+ I + K +D K P ++ ++ +KIK+S LL +L KI P S +L+ + L + + KL S + P LT + LL L++ WTS G NW + + +Y P F +G+Q + D PI D E+ H ++A I +++ L+ +E D ++YR F A ELS+ GE +EV+ES K WW C N +GQ G+ P+ +LEP + + N + +P SP +R +PK S I DP AD + ++N+EL +++ N RA+ RP + + ++ S +VQ+WL+ K F+ ++ L + NG LF L+++E+ R V E R+ S + VQKSL EL+ I+ K+K K ++
Sbjct: 2 AAPAVIPRSRPKSIKVLPTNGTAADLSPIGVHAMNGGDRVKTNTHLI-HAQREVELVNHCFADVEHFMARLQQTAEAKNIQEQLKRSKKKSRKKNKTKKNKKEDDEPTPQKVTPPSEQEFVDIFQKIKYSFCLLDRLKMKISEPSSEELLHHVFVPLQLMVKTTG---GPKLASSISSPALTSGAISLLQHNLNEQEKTLWTSLGPNWTLPYSQLSETVPQYTPVFLDGWQ----PIAVDANGQPIED-------PIEVQHK---HEAF--IQTQQVIDQARLTVHQENDGMEPFPPNEERMYRCSYDFVARNSSELSVLHGESLEVLES--SKRWWKCKNSYGQTGFVPHNILEPINHAEVDSTNVVMRNQSTKAPISP----LRGGRMSYAAPKSESAIHPDPRPLSMPSFADDGEKVVLMNDELIQRLA--------NGRAASVRPMVINKANETTVPLDYHSPQAEVQEWLKAKGFNNITVQSLGVLNGAQLFSLNKEEL-RAVCPEEGARVYSQITVQKSLLE-DVRKATELEAIMKKQKMKADL 515
BLAST of Epidermal growth factor receptor kinase substrate 8 vs. Ensembl Zebrafish
Match: eps8l2 (EPS8 like 2 [Source:ZFIN;Acc:ZDB-GENE-131121-340]) HSP 1 Score: 119.013 bits (297), Expect = 2.638e-27 Identity = 138/499 (27.66%), Postives = 217/499 (43.49%), Query Frame = 2
Query: 629 NDDISSRTERNLLLLNYCFDDIEFFLQHLKDQEEAQAIL------KNTKGKNLNDRLLEGKAKPSTQNAYLTCIEKIKFSLNLLCKLDGKIKNPDSRQXXXXXXXXXXXXGQAYSIYHNGKLSK-VKEPLLTEDTVKLLHQCLSKHYHKQWTSWGDNWCKAREKWAGYK--EKYYPEFFNGYQIDLEELMKDGIISPIADIPRRAVSNAEISHAIFYNQALPMIAQTDILENTVLSSREEDFCRSVTLRNGKLYRVIATFAASKDEELSMSEGEIIEVIESKPDKNWWLCGNMHGQKGYSPNTLL------EPFCYIDRSINNFIKSSPESPDYLNVRNIPTVPVSPKRISQIMKDPNSADKVAEANIINEELKKKINTNSNFGGWNSRASFARPGPVVSKKHGQLSINQDSTSEDVQKWLEYKKFSPSDIEKLKIFNGQTLFLLSRDEMVRIVSSEVANRLDSLVKVQKS-LSGFGTLSRRELDEILTKRKEKVEITE 2077
N ++ R E+++ +LN DDIE F+ L EA A L K K + + +L +AKP ++ ++ C++K+K S NLL KL I+NP++ +LI L L I Q+ + L + V P L+ D V L L+ + GD W + R W + Y P+F NG++ +E + +P+ V + S F + S + S R K ++ F A ELS+ + EI+EV+E K WW N GQ GY P +L +P ID P SP Y SP KD + + + + +N+EL I +N R VV + G L+ +S+ +V WL K FS +E+L I G LF L++D + + V + +R+ S + VQKS L +S EL+EI+ +++EK++ T+
Sbjct: 226 NMKLAQRIEKDVQILNCSLDDIEIFVARLHKAAEAFAQLNQRNRSKKNKKRGPAEGMLTLRAKPPSEVEFVDCLQKLKLSFNLLAKLKKHIQNPNASELIHFLFGPLELILQSSG---SPDLPRAVISPHLSRDAVDFLRGHLTPKEMTIFELLGDGWTRPRADWPKDQCAPLYVPKFRNGWEPPVELFRTSPWETESIGMPKSPVQSEYRSKEFF--------------GSQSSPSSNGSYPPSPAPR--KYAKIRYHFVARNANELSVLQDEILEVLED--GKQWWKLRNRSGQAGYVPYNILDVIKLEDPQAMID---------PPYSPSYRG--------QSPSGSQGSDKDSH----LQQMDKVNDELLMLITSNKIHQP-------TRNFKVVRQSAGPLTF--ESSPAEVTSWLNAKGFSKPTVERLGILTGAQLFSLNKDHL-KAVCGDEGSRVYSQITVQKSQLEKSRGVS--ELEEIMIRQQEKIKSTK 670
BLAST of Epidermal growth factor receptor kinase substrate 8 vs. Ensembl Zebrafish
Match: eps8l2 (EPS8 like 2 [Source:ZFIN;Acc:ZDB-GENE-131121-340]) HSP 1 Score: 119.013 bits (297), Expect = 2.938e-27 Identity = 138/499 (27.66%), Postives = 217/499 (43.49%), Query Frame = 2
Query: 629 NDDISSRTERNLLLLNYCFDDIEFFLQHLKDQEEAQAIL------KNTKGKNLNDRLLEGKAKPSTQNAYLTCIEKIKFSLNLLCKLDGKIKNPDSRQXXXXXXXXXXXXGQAYSIYHNGKLSK-VKEPLLTEDTVKLLHQCLSKHYHKQWTSWGDNWCKAREKWAGYK--EKYYPEFFNGYQIDLEELMKDGIISPIADIPRRAVSNAEISHAIFYNQALPMIAQTDILENTVLSSREEDFCRSVTLRNGKLYRVIATFAASKDEELSMSEGEIIEVIESKPDKNWWLCGNMHGQKGYSPNTLL------EPFCYIDRSINNFIKSSPESPDYLNVRNIPTVPVSPKRISQIMKDPNSADKVAEANIINEELKKKINTNSNFGGWNSRASFARPGPVVSKKHGQLSINQDSTSEDVQKWLEYKKFSPSDIEKLKIFNGQTLFLLSRDEMVRIVSSEVANRLDSLVKVQKS-LSGFGTLSRRELDEILTKRKEKVEITE 2077
N ++ R E+++ +LN DDIE F+ L EA A L K K + + +L +AKP ++ ++ C++K+K S NLL KL I+NP++ +LI L L I Q+ + L + V P L+ D V L L+ + GD W + R W + Y P+F NG++ +E + +P+ V + S F + S + S R K ++ F A ELS+ + EI+EV+E K WW N GQ GY P +L +P ID P SP Y SP KD + + + + +N+EL I +N R VV + G L+ +S+ +V WL K FS +E+L I G LF L++D + + V + +R+ S + VQKS L +S EL+EI+ +++EK++ T+
Sbjct: 207 NMKLAQRIEKDVQILNCSLDDIEIFVARLHKAAEAFAQLNQRNRSKKNKKRGPAEGMLTLRAKPPSEVEFVDCLQKLKLSFNLLAKLKKHIQNPNASELIHFLFGPLELILQSSG---SPDLPRAVISPHLSRDAVDFLRGHLTPKEMTIFELLGDGWTRPRADWPKDQCAPLYVPKFRNGWEPPVELFRTSPWETESIGMPKSPVQSEYRSKEFF--------------GSQSSPSSNGSYPPSPAPR--KYAKIRYHFVARNANELSVLQDEILEVLED--GKQWWKLRNRSGQAGYVPYNILDVIKLEDPQAMID---------PPYSPSYRG--------QSPSGSQGSDKDSH----LQQMDKVNDELLMLITSNKIHQP-------TRNFKVVRQSAGPLTF--ESSPAEVTSWLNAKGFSKPTVERLGILTGAQLFSLNKDHL-KAVCGDEGSRVYSQITVQKSQLEKSRGVS--ELEEIMIRQQEKIKSTK 651
BLAST of Epidermal growth factor receptor kinase substrate 8 vs. Ensembl Xenopus
Match: eps8 (epidermal growth factor receptor pathway substrate 8 [Source:NCBI gene;Acc:779963]) HSP 1 Score: 127.102 bits (318), Expect = 1.466e-29 Identity = 131/509 (25.74%), Postives = 224/509 (44.01%), Query Frame = 2
Query: 614 DSKPRNDDISSRTERNLLLLNYCFDDIEFFLQHLKDQEEAQAILKNTKGKNLNDR----LLEGKAKPSTQNAYLTCIEKIKFSLNLLCKLDGKIKNPDSRQXXXXXXXXXXXXGQAYSIYHNGKLSK-VKEPLLTEDTVKLLHQCLSKHYHKQWTSWGDNWCKAREKWAG--YKEKYYPEFFNGYQIDLEELMKDGIISPIADIPRRAVSNAEISHAIFYNQALPMIAQTDILENTVLSSREEDFCRSVTLRNGKLYRVIATFAASKDEELSMSEGEIIEVIESKPDKNWWLCGNMHGQKGYSPNTLLEPFCYIDRSINNFIKSSPESPDYLNVRNIPT----VPVSP-----KRISQIMKDPNSADKVAEANIINEELKKKINTNSNFGGWNSRASFARPGPVVSKKHGQLSINQDSTSEDVQKWLEYKKFSPSDIEKLKIFNGQTLFLLSRDEMVRIVSSEVANRLDSLVKVQKSL----SGFGTLSRRELDEILTKRKEKVEITET 2080
DS P + +R +R++ +LN+ DD+EFF+ L+ EA + L K +L +A+P Q ++ C +K K +NLL KL I+NP + +L+ L L + +A L++ V PL+T+D++ L+ L+K + WTS GD+W K R +W + Y P F NG++ L ++ + + AE+ +N M + + E +F + + F A ELS+ + +++EV++ K K WW + G G+ PN +L D+S + P Y + +P+ +P SP R SQ+ EE++ ++ G ++ F P H I+ S +EDV+ WL+ K F+ ++ L + G LF L++DE+ + V E R+ + V VQK+ SG EL EI+ KR+E++ + +
Sbjct: 253 DSTPEM--LEARIDRDVQILNHILDDVEFFIMKLQKAAEAFSELSKRKKGKKKKGPGEGVLTLRARPPPQEEFVDCFQKFKHGINLLAKLKSHIQNPSASELVHFLFTPLHMMVEATG---GPDLARTVLSPLITKDSLDFLNFILNKEEKQLWTSLGDSWNKYRAEWPKEQFIPPYVPRFRNGWEPPLLGCAAAPKEQELSYLAESVANVAELQRKQEFNSVPNMYSHV-----SRYPPSEGNFEERDQVEAQRYALCKYDFVARNSNELSVLKDDVLEVLDDK--KQWWKVRSSSGAVGFVPNNILVAMKPQDQS------AKPMEAAYTHTIQVPSSAWVIPDSPCSFGVGRKSQM-----------------EEVQDELIHRLTIGRSAAQKKFTVPRLNAPAVH----ISHSSPAEDVKSWLQAKGFNSVTVDSLGVLTGAQLFSLTKDEL-KTVCPE-GPRVYNQVTVQKAAIEEQSGGS-----ELLEIMKKRQERINMAAS 715
BLAST of Epidermal growth factor receptor kinase substrate 8 vs. Ensembl Xenopus
Match: EPS8L2 (EPS8-like 2 [Source:NCBI gene;Acc:100489749]) HSP 1 Score: 125.561 bits (314), Expect = 3.200e-29 Identity = 141/500 (28.20%), Postives = 218/500 (43.60%), Query Frame = 2
Query: 572 NSYSNEKMNKVKEYDSKPRNDDISSRTERNLLLLNYCFDDIEFFLQHLKDQEEAQAILKNTKGKNLNDR--------------LLEGKAKPSTQNAYLTCIEKIKFSLNLLCKLDGKIKNPDSRQXXXXXXXXXXXXGQAYSIYHNGKLSKVKEPLLTEDTVKLLHQCLSKHYHKQWTSWGDNWCKAREKWAGYK--EKYYPEFFNGYQIDLEELMKDGIISPIADIPRRAVSNAEISHAIFYNQALPMIAQTDILENTVLSSREEDFCRSVTLRNGKLYRVIATFAASKDEELSMSEGEIIEVIESKPDKNWWLCGNMHGQKGYSPNTLLEPFCYIDRSINNFIKSSPESPDYLNVRNIPTVPV--SPKRISQIMKDPNSADK---VAEANIINEELKKKINTNS----NFGGWNSRASFARPGPVVSKKHGQLSINQDSTSEDVQKWLEYKKFSPSDIEKLKIFNGQTLFLLSRDEMVRIVSSEVANRLDSLVKVQKS 1996
N +++ + V + +PR + ++ + E++ +LN DDIEFF+ L+ EA K LN R +L ++KP T+ ++ C +KIK ++NLL KL I+NP S +LI L L I Q+ G+ + PLL+ D L L+ W GD W K R +W Y P+F NG+ I E+ + A P E I P + +L L R ++ V + KL ++ F A ELS+ + E++EV+E +K WW N GQ+GY P +L+ + NN SP + P+ PV P + N ++K + + +N+EL KKI TN NF +A + + +N S E+V+ WLE K FS +L I NG LF L+++E+ ++ E A R+ S + VQKS
Sbjct: 201 NDIEHDRRSNVSQEPEEPR-EVLAQKIEKDTQVLNCTLDDIEFFVAKLQKAAEA--------FKQLNQRKKGKKNKKKGHAEGMLTLRSKPPTEFEFVDCYQKIKLAINLLAKLKKHIQNPSSAELIHFLFGPLELIIQSSGGPELGR--SILAPLLSRDATDFLRGHLTPKEMAIWEVLGDRWTKCRAEWPREPPIPLYIPKFNNGW-IPPVEIFQGAPWETEAHPP-------EPKPRIQEEVRSPANGCSFLLTFFHLEVR--NYEAPVPAQPQKLAKIRYDFTARNANELSVLKDEVLEVLED--NKQWWKLRNRIGQEGYVPYNILD---IMSTEENNSRYREDMSPRGVG----PSSPVYKHPSTFAGDKWSTNPSNKEQLIHHMDEVNDELLKKITTNQPAKRNFKVDKPQAVY-------------VPLNYQSEPEEVKAWLEAKGFSKGTASQLGILNGAQLFSLNKEELRKVCGEEGA-RVYSQLAVQKS 656
BLAST of Epidermal growth factor receptor kinase substrate 8 vs. Ensembl Xenopus
Match: EPS8L2 (EPS8-like 2 [Source:NCBI gene;Acc:100489749]) HSP 1 Score: 125.561 bits (314), Expect = 3.754e-29 Identity = 141/500 (28.20%), Postives = 218/500 (43.60%), Query Frame = 2
Query: 572 NSYSNEKMNKVKEYDSKPRNDDISSRTERNLLLLNYCFDDIEFFLQHLKDQEEAQAILKNTKGKNLNDR--------------LLEGKAKPSTQNAYLTCIEKIKFSLNLLCKLDGKIKNPDSRQXXXXXXXXXXXXGQAYSIYHNGKLSKVKEPLLTEDTVKLLHQCLSKHYHKQWTSWGDNWCKAREKWAGYK--EKYYPEFFNGYQIDLEELMKDGIISPIADIPRRAVSNAEISHAIFYNQALPMIAQTDILENTVLSSREEDFCRSVTLRNGKLYRVIATFAASKDEELSMSEGEIIEVIESKPDKNWWLCGNMHGQKGYSPNTLLEPFCYIDRSINNFIKSSPESPDYLNVRNIPTVPV--SPKRISQIMKDPNSADK---VAEANIINEELKKKINTNS----NFGGWNSRASFARPGPVVSKKHGQLSINQDSTSEDVQKWLEYKKFSPSDIEKLKIFNGQTLFLLSRDEMVRIVSSEVANRLDSLVKVQKS 1996
N +++ + V + +PR + ++ + E++ +LN DDIEFF+ L+ EA K LN R +L ++KP T+ ++ C +KIK ++NLL KL I+NP S +LI L L I Q+ G+ + PLL+ D L L+ W GD W K R +W Y P+F NG+ I E+ + A P E I P + +L L R ++ V + KL ++ F A ELS+ + E++EV+E +K WW N GQ+GY P +L+ + NN SP + P+ PV P + N ++K + + +N+EL KKI TN NF +A + + +N S E+V+ WLE K FS +L I NG LF L+++E+ ++ E A R+ S + VQKS
Sbjct: 193 NDIEHDRRSNVSQEPEEPR-EVLAQKIEKDTQVLNCTLDDIEFFVAKLQKAAEA--------FKQLNQRKKGKKNKKKGHAEGMLTLRSKPPTEFEFVDCYQKIKLAINLLAKLKKHIQNPSSAELIHFLFGPLELIIQSSGGPELGR--SILAPLLSRDATDFLRGHLTPKEMAIWEVLGDRWTKCRAEWPREPPIPLYIPKFNNGW-IPPVEIFQGAPWETEAHPP-------EPKPRIQEEVRSPANGCSFLLTFFHLEVR--NYEAPVPAQPQKLAKIRYDFTARNANELSVLKDEVLEVLED--NKQWWKLRNRIGQEGYVPYNILD---IMSTEENNSRYREDMSPRGVG----PSSPVYKHPSTFAGDKWSTNPSNKEQLIHHMDEVNDELLKKITTNQPAKRNFKVDKPQAVY-------------VPLNYQSEPEEVKAWLEAKGFSKGTASQLGILNGAQLFSLNKEELRKVCGEEGA-RVYSQLAVQKS 648
BLAST of Epidermal growth factor receptor kinase substrate 8 vs. Ensembl Xenopus
Match: EPS8L2 (EPS8-like 2 [Source:NCBI gene;Acc:100489749]) HSP 1 Score: 125.176 bits (313), Expect = 4.193e-29 Identity = 141/500 (28.20%), Postives = 218/500 (43.60%), Query Frame = 2
Query: 572 NSYSNEKMNKVKEYDSKPRNDDISSRTERNLLLLNYCFDDIEFFLQHLKDQEEAQAILKNTKGKNLNDR--------------LLEGKAKPSTQNAYLTCIEKIKFSLNLLCKLDGKIKNPDSRQXXXXXXXXXXXXGQAYSIYHNGKLSKVKEPLLTEDTVKLLHQCLSKHYHKQWTSWGDNWCKAREKWAGYK--EKYYPEFFNGYQIDLEELMKDGIISPIADIPRRAVSNAEISHAIFYNQALPMIAQTDILENTVLSSREEDFCRSVTLRNGKLYRVIATFAASKDEELSMSEGEIIEVIESKPDKNWWLCGNMHGQKGYSPNTLLEPFCYIDRSINNFIKSSPESPDYLNVRNIPTVPV--SPKRISQIMKDPNSADK---VAEANIINEELKKKINTNS----NFGGWNSRASFARPGPVVSKKHGQLSINQDSTSEDVQKWLEYKKFSPSDIEKLKIFNGQTLFLLSRDEMVRIVSSEVANRLDSLVKVQKS 1996
N +++ + V + +PR + ++ + E++ +LN DDIEFF+ L+ EA K LN R +L ++KP T+ ++ C +KIK ++NLL KL I+NP S +LI L L I Q+ G+ + PLL+ D L L+ W GD W K R +W Y P+F NG+ I E+ + A P E I P + +L L R ++ V + KL ++ F A ELS+ + E++EV+E +K WW N GQ+GY P +L+ + NN SP + P+ PV P + N ++K + + +N+EL KKI TN NF +A + + +N S E+V+ WLE K FS +L I NG LF L+++E+ ++ E A R+ S + VQKS
Sbjct: 200 NDIEHDRRSNVSQEPEEPR-EVLAQKIEKDTQVLNCTLDDIEFFVAKLQKAAEA--------FKQLNQRKKGKKNKKKGHAEGMLTLRSKPPTEFEFVDCYQKIKLAINLLAKLKKHIQNPSSAELIHFLFGPLELIIQSSGGPELGR--SILAPLLSRDATDFLRGHLTPKEMAIWEVLGDRWTKCRAEWPREPPIPLYIPKFNNGW-IPPVEIFQGAPWETEAHPP-------EPKPRIQEEVRSPANGCSFLLTFFHLEVR--NYEAPVPAQPQKLAKIRYDFTARNANELSVLKDEVLEVLED--NKQWWKLRNRIGQEGYVPYNILD---IMSTEENNSRYREDMSPRGVG----PSSPVYKHPSTFAGDKWSTNPSNKEQLIHHMDEVNDELLKKITTNQPAKRNFKVDKPQAVY-------------VPLNYQSEPEEVKAWLEAKGFSKGTASQLGILNGAQLFSLNKEELRKVCGEEGA-RVYSQLAVQKS 655
BLAST of Epidermal growth factor receptor kinase substrate 8 vs. Ensembl Xenopus
Match: eps8 (epidermal growth factor receptor pathway substrate 8 [Source:NCBI gene;Acc:779963]) HSP 1 Score: 122.479 bits (306), Expect = 4.710e-28 Identity = 137/554 (24.73%), Postives = 237/554 (42.78%), Query Frame = 2
Query: 614 DSKPRNDDISSRTERNLLLLNYCFDDIEFFLQHLKDQEEAQAILKNTKGKNLNDR------LLEGKAKPSTQNAYLTCIEKIKFSLNLLCKLDGKIKNPDSRQXXXXXXXXXXXXGQAYSIYHNGKLSK-VKEPLLTEDTVKLLHQCLSKHYHKQWTSWGDNWCKAREKWAG--YKEKYYPEFFNGYQIDL---------EEL--MKDGIISPIADIPRRAVSNAEISHAIFYNQALPMIAQTDILENTVLSSREEDFCRSVTLRNGKLYRVIATFAASKDEELSMSEGEIIEVIESKPDKNWWLCGNMHGQKGYSPNTLL-----------------------------EPFCYIDR---------SINNFIKSSPESPDYLNVRNIPTVPVSPKRISQIMKDPNSADKVAEANIINEELKKKINTNSNFGGWNSRASFARP---GPVVSKKHGQLSINQDSTSEDVQKWLEYKKFSPSDIEKLKIFNGQTLFLLSRDEMVRIVSSEVANRLDSLVKVQKSL----SGFGTLSRRELDEILTKRKEKVEITET 2080
DS P + +R +R++ +LN+ DD+EFF+ L+ EA + L K +L +A+P Q ++ C +K K +NLL KL I+NP + +L+ L L + +A L++ V PL+T+D++ L+ L+K + WTS GD+W K R +W + Y P F NG++ L +EL + + + + +A++ R+ N+ SH Y ++ + E + ++ C+ F A ELS+ + +++EV++ K K WW + G G+ PN +L C+ R + + SP Y V +P P P Q+ P S ++ + EE++ ++ G ++ F P P V I+ S +EDV+ WL+ K F+ ++ L + G LF L++DE+ + V E R+ + V VQK+ SG EL EI+ KR+E++ + +
Sbjct: 214 DSTPEM--LEARIDRDVQILNHILDDVEFFIMKLQKAAEAFSELSKRKKGKKKKGPGGEEGVLTLRARPPPQEEFVDCFQKFKHGINLLAKLKSHIQNPSASELVHFLFTPLHMMVEATG---GPDLARTVLSPLITKDSLDFLNFILNKEEKQLWTSLGDSWNKYRAEWPKEQFIPPYVPRFRNGWEPPLLGCAAAPKEQELSYLAESVAN-VAELQRKQEFNS-YSHVSRYPP-----SEGNFEERDQVEAQRYALCK-------------YDFVARNSNELSVLKDDVLEVLDDK--KQWWKVRSSSGAVGFVPNNILVAMKPQDQSAKPMEAAYTHTIQLSSECSSPALCFTHRLPAPPPVSSHQRVLVPPTASSPAYCFVHRLPAPP--PVSSHQVPDSPCSFGVGRKSQM--EEVQDELIHRLTIGRSAAQKKFTVPRLNAPAV-------HISHSSPAEDVKSWLQAKGFNSVTVDSLGVLTGAQLFSLTKDEL-KTVCPE-GPRVYNQVTVQKAAIEEQSGGS-----ELLEIMKKRQERINMAAS 722
BLAST of Epidermal growth factor receptor kinase substrate 8 vs. Ensembl Mouse
Match: Eps8l1 (EPS8-like 1 [Source:MGI Symbol;Acc:MGI:1914675]) HSP 1 Score: 133.65 bits (335), Expect = 8.058e-32 Identity = 143/512 (27.93%), Postives = 227/512 (44.34%), Query Frame = 2
Query: 614 DSKPRNDDISS-RTERNLLLLNYCFDDIEFFLQHLKDQEEAQAILKNTKGKNLNDR------LLEGKAKPSTQNAYLTCIEKIKFSLNLLCKLDGKIKNPDSRQXXXXXXXXXXXXGQAYSIYHNGKLSKVKEPLLTEDTVKLLHQCLSKHYHKQWTSWGDNW-CKAREKWAGYKEKYYPEFFNGYQIDLEELMKDGIISPIADIPRRAVSNAEISHAIFYNQALPMIA----QTDILENTVLSSREEDFCRSVTLRNGKLYRVIATFAASKDEELSMSEGEIIEVIESKPDKNWWLCGNMHGQKGYSPNTLLEPFCYIDRSINNFIKSSPESPDYLNVRNIPTVPVSPKRISQIMK-----------DPNSADKVAEANIINEELKKKINTNSNFGGWNSRASFARPGPVVSKKHGQLSINQDSTSEDVQKWLEYKKFSPSDIEKLKIFNGQTLFLLSRDEMVRIVSSEVANRLDSLVKVQKSLSGFGTLSRR----ELDEILTKRKEKVE 2068
D PR +++ + ER++ +LN+ FDD+E F+ L+ EA +L++ + R LL +AKP T+ Y ++KIK++ +LL +L G I NP S +L+ L L I K V+ P LT + V LL ++ ++ WTS GD+W C E Y PEF+NG+ E D P D + + + + Q+ P +A Q LE S+ E+ R L N F A ELS+ +++EV++ + + WW + GQ+GY P +L P + S +L P P +Q+ DP+ +K ++ +NEEL+ ++ S S PGP + QLS +++ V+ WL+ K FS +E L + G LF L ++E+ R V E R+ S V VQ++L L R EL+ ++ K+K+KVE
Sbjct: 241 DLGPRGPELAGLQAERDVDILNHVFDDVESFVSRLQKSAEATRVLEHRERGRRTRRRAAGEGLLTLRAKPPTEAEYTDVLQKIKYAFSLLARLRGNIANPSSPELLHFLFGPLQMIVNTSGGPEFAK--SVRRPHLTLEAVTLLRDNVTPGENELWTSLGDSWTCPGVELPPEEGSPYSPEFYNGW----EPPATDPQGRPWEDPVEKQLQHEKRRR----QQSAPQVAVNGQQDPELET---ESQLEEKARKWVLCN-------YDFQARNGSELSVKHRDVLEVLDDR--RKWWKVRDHQGQEGYVPYNILTPHP------GPQVHRSQSPARHLETSTPPPPPAPAPAPTQVRPQWDSCDSLNSLDPSEKEKFSQMLCVNEELQSRLAQG------RSGPSRVTPGP--RAQEPQLSPRSEASV--VRAWLQTKGFSSGTVEALGVLTGAQLFSLQKEEL-RAVCPEEGARVYSQVTVQRAL-----LEDREKVSELEAVMEKQKKKVE 708
BLAST of Epidermal growth factor receptor kinase substrate 8 vs. Ensembl Mouse
Match: Eps8l1 (EPS8-like 1 [Source:MGI Symbol;Acc:MGI:1914675]) HSP 1 Score: 133.65 bits (335), Expect = 8.058e-32 Identity = 143/512 (27.93%), Postives = 227/512 (44.34%), Query Frame = 2
Query: 614 DSKPRNDDISS-RTERNLLLLNYCFDDIEFFLQHLKDQEEAQAILKNTKGKNLNDR------LLEGKAKPSTQNAYLTCIEKIKFSLNLLCKLDGKIKNPDSRQXXXXXXXXXXXXGQAYSIYHNGKLSKVKEPLLTEDTVKLLHQCLSKHYHKQWTSWGDNW-CKAREKWAGYKEKYYPEFFNGYQIDLEELMKDGIISPIADIPRRAVSNAEISHAIFYNQALPMIA----QTDILENTVLSSREEDFCRSVTLRNGKLYRVIATFAASKDEELSMSEGEIIEVIESKPDKNWWLCGNMHGQKGYSPNTLLEPFCYIDRSINNFIKSSPESPDYLNVRNIPTVPVSPKRISQIMK-----------DPNSADKVAEANIINEELKKKINTNSNFGGWNSRASFARPGPVVSKKHGQLSINQDSTSEDVQKWLEYKKFSPSDIEKLKIFNGQTLFLLSRDEMVRIVSSEVANRLDSLVKVQKSLSGFGTLSRR----ELDEILTKRKEKVE 2068
D PR +++ + ER++ +LN+ FDD+E F+ L+ EA +L++ + R LL +AKP T+ Y ++KIK++ +LL +L G I NP S +L+ L L I K V+ P LT + V LL ++ ++ WTS GD+W C E Y PEF+NG+ E D P D + + + + Q+ P +A Q LE S+ E+ R L N F A ELS+ +++EV++ + + WW + GQ+GY P +L P + S +L P P +Q+ DP+ +K ++ +NEEL+ ++ S S PGP + QLS +++ V+ WL+ K FS +E L + G LF L ++E+ R V E R+ S V VQ++L L R EL+ ++ K+K+KVE
Sbjct: 241 DLGPRGPELAGLQAERDVDILNHVFDDVESFVSRLQKSAEATRVLEHRERGRRTRRRAAGEGLLTLRAKPPTEAEYTDVLQKIKYAFSLLARLRGNIANPSSPELLHFLFGPLQMIVNTSGGPEFAK--SVRRPHLTLEAVTLLRDNVTPGENELWTSLGDSWTCPGVELPPEEGSPYSPEFYNGW----EPPATDPQGRPWEDPVEKQLQHEKRRR----QQSAPQVAVNGQQDPELET---ESQLEEKARKWVLCN-------YDFQARNGSELSVKHRDVLEVLDDR--RKWWKVRDHQGQEGYVPYNILTPHP------GPQVHRSQSPARHLETSTPPPPPAPAPAPTQVRPQWDSCDSLNSLDPSEKEKFSQMLCVNEELQSRLAQG------RSGPSRVTPGP--RAQEPQLSPRSEASV--VRAWLQTKGFSSGTVEALGVLTGAQLFSLQKEEL-RAVCPEEGARVYSQVTVQRAL-----LEDREKVSELEAVMEKQKKKVE 708
BLAST of Epidermal growth factor receptor kinase substrate 8 vs. Ensembl Mouse
Match: Eps8l1 (EPS8-like 1 [Source:MGI Symbol;Acc:MGI:1914675]) HSP 1 Score: 133.65 bits (335), Expect = 8.991e-32 Identity = 143/512 (27.93%), Postives = 227/512 (44.34%), Query Frame = 2
Query: 614 DSKPRNDDISS-RTERNLLLLNYCFDDIEFFLQHLKDQEEAQAILKNTKGKNLNDR------LLEGKAKPSTQNAYLTCIEKIKFSLNLLCKLDGKIKNPDSRQXXXXXXXXXXXXGQAYSIYHNGKLSKVKEPLLTEDTVKLLHQCLSKHYHKQWTSWGDNW-CKAREKWAGYKEKYYPEFFNGYQIDLEELMKDGIISPIADIPRRAVSNAEISHAIFYNQALPMIA----QTDILENTVLSSREEDFCRSVTLRNGKLYRVIATFAASKDEELSMSEGEIIEVIESKPDKNWWLCGNMHGQKGYSPNTLLEPFCYIDRSINNFIKSSPESPDYLNVRNIPTVPVSPKRISQIMK-----------DPNSADKVAEANIINEELKKKINTNSNFGGWNSRASFARPGPVVSKKHGQLSINQDSTSEDVQKWLEYKKFSPSDIEKLKIFNGQTLFLLSRDEMVRIVSSEVANRLDSLVKVQKSLSGFGTLSRR----ELDEILTKRKEKVE 2068
D PR +++ + ER++ +LN+ FDD+E F+ L+ EA +L++ + R LL +AKP T+ Y ++KIK++ +LL +L G I NP S +L+ L L I K V+ P LT + V LL ++ ++ WTS GD+W C E Y PEF+NG+ E D P D + + + + Q+ P +A Q LE S+ E+ R L N F A ELS+ +++EV++ + + WW + GQ+GY P +L P + S +L P P +Q+ DP+ +K ++ +NEEL+ ++ S S PGP + QLS +++ V+ WL+ K FS +E L + G LF L ++E+ R V E R+ S V VQ++L L R EL+ ++ K+K+KVE
Sbjct: 302 DLGPRGPELAGLQAERDVDILNHVFDDVESFVSRLQKSAEATRVLEHRERGRRTRRRAAGEGLLTLRAKPPTEAEYTDVLQKIKYAFSLLARLRGNIANPSSPELLHFLFGPLQMIVNTSGGPEFAK--SVRRPHLTLEAVTLLRDNVTPGENELWTSLGDSWTCPGVELPPEEGSPYSPEFYNGW----EPPATDPQGRPWEDPVEKQLQHEKRRR----QQSAPQVAVNGQQDPELET---ESQLEEKARKWVLCN-------YDFQARNGSELSVKHRDVLEVLDDR--RKWWKVRDHQGQEGYVPYNILTPHP------GPQVHRSQSPARHLETSTPPPPPAPAPAPTQVRPQWDSCDSLNSLDPSEKEKFSQMLCVNEELQSRLAQG------RSGPSRVTPGP--RAQEPQLSPRSEASV--VRAWLQTKGFSSGTVEALGVLTGAQLFSLQKEEL-RAVCPEEGARVYSQVTVQRAL-----LEDREKVSELEAVMEKQKKKVE 769
BLAST of Epidermal growth factor receptor kinase substrate 8 vs. Ensembl Mouse
Match: Eps8l2 (EPS8-like 2 [Source:MGI Symbol;Acc:MGI:2138828]) HSP 1 Score: 118.242 bits (295), Expect = 7.485e-27 Identity = 128/497 (25.75%), Postives = 215/497 (43.26%), Query Frame = 2
Query: 578 YSNEKMNKVKEYDSKPRNDDISSRTERNLLLLNYCFDDIEFFLQHLKDQEEAQAILKNTKGKNLNDR--------------LLEGKAKPSTQNAYLTCIEKIKFSLNLLCKLDGKIKNPDSRQXXXXXXXXXXXXGQAYSIYHNGKLSKVKEPLLTEDTVKLLHQCLSKHYHKQWTSWGDNWCKAREKWAGYKEK--YYPEFFNGYQIDLEELMK-----DGIISPIAD--IPRRAVSNAEISHAIFYNQALPMIAQTDILENTVLSSREEDFCRSVTLRNGKLYRVIATFAASKDEELSMSEGEIIEVIESKPDKNWWLCGNMHGQKGYSPNTLLEPFCYIDRSINNFIKSSPESPDYLNVRNIPTVPVSPKRISQIMKDPNSADKVAEANIINEELKKKINTNSNFGGWNSRASFARPGPVVSKKHGQLSINQDSTSEDVQKWLEYKKFSPSDIEKLKIFNGQTLFLLSRDEMVRIVSSEVANRLDSLVKVQKSL 1999
+S + + D +PR ++ R E+ +LN DDIE+F+ L+ EA K LN R +L +A+P ++ ++ C +K K ++NLL KL I+NP + +L+ L L I + V PLL+ D V L L W S G+ W + R +W + Y P+F +G++ L+ L + +G+ S +D P+ +S + H+ ++ + A DI SS + T K +++ F A ELS+ + E++EV+E + WW N GQ GY P +L D + ++ S + Y P SP + N + + + +N+EL KKI+ N R ++P L + +S ++V+ WLE K FS +E L I G LF L+++E+ ++ E +R+ S + VQK+
Sbjct: 232 FSEPGYRRRESQDEEPRAV-LAQRIEKETQILNCTLDDIEWFVARLQKAAEA--------FKQLNQRKKGKKKNKKGPAEGVLTLRARPPSEGEFVDCFQKTKLAINLLAKLQKHIQNPSAAELVHFLFGPLDLIINTCGSPDIAR--SVSSPLLSTDAVSFLRGHLVPKEMTLWESLGETWMRPRSEWPREPQVPLYVPKFRSGWEPPLDVLQEAPWEVEGLASVPSDQLTPKNRLS---VRHSPKHSLSSESQAPEDIAPPG--SSPHANRGYQPTPAMTKYVKILYDFTARNANELSVLKDEVLEVLED--GRQWWKLRNRSGQAGYVPCNILAEARQED--VGAPLEQSGQK--YWG-------PASPTHKLPPIFAGNKEELIHHMDEVNDELMKKISHIKTQPQRNFRVERSQP--------VHLPLTFESGPDEVRAWLEAKAFSARIVENLGILTGPQLFSLNKEELKKVCGEE-GSRVYSQLTVQKAF 690
BLAST of Epidermal growth factor receptor kinase substrate 8 vs. Ensembl Mouse
Match: Eps8l3 (EPS8-like 3 [Source:MGI Symbol;Acc:MGI:2139743]) HSP 1 Score: 97.0561 bits (240), Expect = 2.004e-20 Identity = 87/293 (29.69%), Postives = 134/293 (45.73%), Query Frame = 2
Query: 653 ERNLLLLNYCFDDIEFFLQHLKDQEEAQAILKNTKGKNLNDRLLEGKAKPSTQNAYLTCIEKIKFSLNLLCKLDGKIKNPDSRQXXXXXXXXXXXXGQAYSIYHNGKLSKVKEPLLTEDTVKLLHQCLSKHYHKQWTSWGDNWCKAREKWAGYK-EKYYPEFFNGYQIDLEELMKDGIISPIADIPRRAVSNAEISHAIFYNQALPMIAQTDILE-NTVLSSREEDFCRSVTLRNGKLYRVIATFAASKDEELSMSEGEIIEVIESKPDKNWWLCGNMHGQKGYSPNTLLEPF 1525
ER+ +LN+ DIE F LK E QA +N+ K R + TQ Y+ C +KIK S NLL KL +++ + + + L+ + L I G +KV PLLT + LL CLS W S G +W + W G + Y P F++G+QI M PI + ++ + + ++ + + P + + N LSS R +V+ F A +EL++++GEI+EV++ K WWL N G GY P+ +LEP
Sbjct: 243 ERDEEVLNHVLRDIELFAGKLK---EVQA--RNSHKKTKLGRKKKKSKNGITQAEYIDCFQKIKLSFNLLGKLALRMQETSAPEFVGLIFQTLKFI--LSQCPEAGLPAKVISPLLTPKAIDLLQSCLSPPEDTLWKSLGTSWTTSWADWTGSEPPPYQPTFYDGWQIPQPRSMM-----PITNQDSISLRGSRMRSSLHFPRDEPYNHNPEYEDSNLPLSSPSPG-------RAALKMQVLYEFEARNAQELTVAQGEILEVLDQ--SKRWWLVKNEAGLTGYIPSNILEPL 514
BLAST of Epidermal growth factor receptor kinase substrate 8 vs. UniProt/SwissProt
Match: sp|Q8TE68|ES8L1_HUMAN (Epidermal growth factor receptor kinase substrate 8-like protein 1 OS=Homo sapiens OX=9606 GN=EPS8L1 PE=1 SV=3) HSP 1 Score: 138.658 bits (348), Expect = 1.415e-32 Identity = 142/529 (26.84%), Postives = 237/529 (44.80%), Query Frame = 2
Query: 614 DSKPRNDDISS-RTERNLLLLNYCFDDIEFFLQHLKDQEEAQAILKNTKGKNLNDR------LLEGKAKPSTQNAYLTCIEKIKFSLNLLCKLDGKIKNPDSRQX-----XXXXXXXXXXXGQAYSIYHNGKLSKVKEPLLTEDTVKLLHQCLSKHYHKQWTSWGDNWCK-AREKWAGYKEKYYPEFFNGYQIDLEELMKDGIISPIADIPRRAVSNA---EISHA-IFYNQALPMIAQTDILENTVLSSREEDFCRSVTLRNGKLYRVIATFAASKDEELSMSEGEIIEVIESKPDKNWWLCGNMHGQKGYSPNTLLEPFC--------YIDRSINN---------------FIKSSPESPDYLNVRNIPTVPVSPKRISQIMKDPNSADKVAEANIINEELKKKINTNSNFGGWNSRASFARPGPVVSKKHGQLSINQDSTSEDVQKWLEYKKFSPSDIEKLKIFNGQTLFLLSRDEMVRIVSSEVANRLDSLVKVQKSLSGFGTLSRR----ELDEILTKRKEKVE 2068
D PR D++ + ER + +LN+ FDD+E F+ L+ EA +L++ + + R LL +AKP ++ Y ++KIK++ +LL +L G I +P S +L L + G ++ S V+ P LT D V LL ++ ++ WTS GD+W + E Y PEFF+G++ P+ D RA + ++ H Q+ P +A + + L E S T GK F A ELS+ + +++EV++ + WW + GQ+GY P +L P+ RS+N+ + + P + + ++ + DP+ +K ++ I+NEEL+ ++ S S A PGP + QLS D++ +V+ WL+ K FS ++ L + G LF L ++E+ R VS E R+ S V VQ+SL L + EL+ ++ K+K+KVE
Sbjct: 241 DLGPRGPDLAVLQAEREVDILNHVFDDVESFVSRLQKSAEAARVLEHRERGRRSRRRAAGEGLLTLRAKPPSEAEYTDVLQKIKYAFSLLARLRGNIADPSSPELLHFLFGPLQMIVNTSGGPEFA-------SSVRRPHLTSDAVALLRDNVTPRENELWTSLGDSWTRPGLELSPEEGPPYRPEFFSGWE------------PPVTDPQSRAWEDPVEKQLQHERRRRQQSAPQVA---VNGHRDLEPESEPQLESET--AGKWVLCNYDFQARNSSELSVKQRDVLEVLDDS--RKWWKVRDPAGQEGYVPYNILTPYPGPRLHHSQSPARSLNSTPPPPPAPAPAPPPALARPRWDRPRWDSCDSLNGL------------DPSEKEKFSQMLIVNEELQARLAQG------RSGPSRAVPGPRAPEP--QLSPGSDAS--EVRAWLQAKGFSSGTVDALGVLTGAQLFSLQKEEL-RAVSPEEGARVYSQVTVQRSL-----LEDKEKVSELEAVMEKQKKKVE 715
BLAST of Epidermal growth factor receptor kinase substrate 8 vs. UniProt/SwissProt
Match: sp|Q8R5F8|ES8L1_MOUSE (Epidermal growth factor receptor kinase substrate 8-like protein 1 OS=Mus musculus OX=10090 GN=Eps8l1 PE=1 SV=1) HSP 1 Score: 133.65 bits (335), Expect = 5.637e-31 Identity = 143/512 (27.93%), Postives = 227/512 (44.34%), Query Frame = 2
Query: 614 DSKPRNDDISS-RTERNLLLLNYCFDDIEFFLQHLKDQEEAQAILKNTKGKNLNDR------LLEGKAKPSTQNAYLTCIEKIKFSLNLLCKLDGKIKNPDSRQXXXXXXXXXXXXGQAYSIYHNGKLSKVKEPLLTEDTVKLLHQCLSKHYHKQWTSWGDNW-CKAREKWAGYKEKYYPEFFNGYQIDLEELMKDGIISPIADIPRRAVSNAEISHAIFYNQALPMIA----QTDILENTVLSSREEDFCRSVTLRNGKLYRVIATFAASKDEELSMSEGEIIEVIESKPDKNWWLCGNMHGQKGYSPNTLLEPFCYIDRSINNFIKSSPESPDYLNVRNIPTVPVSPKRISQIMK-----------DPNSADKVAEANIINEELKKKINTNSNFGGWNSRASFARPGPVVSKKHGQLSINQDSTSEDVQKWLEYKKFSPSDIEKLKIFNGQTLFLLSRDEMVRIVSSEVANRLDSLVKVQKSLSGFGTLSRR----ELDEILTKRKEKVE 2068
D PR +++ + ER++ +LN+ FDD+E F+ L+ EA +L++ + R LL +AKP T+ Y ++KIK++ +LL +L G I NP S +L+ L L I K V+ P LT + V LL ++ ++ WTS GD+W C E Y PEF+NG+ E D P D + + + + Q+ P +A Q LE S+ E+ R L N F A ELS+ +++EV++ + + WW + GQ+GY P +L P + S +L P P +Q+ DP+ +K ++ +NEEL+ ++ S S PGP + QLS +++ V+ WL+ K FS +E L + G LF L ++E+ R V E R+ S V VQ++L L R EL+ ++ K+K+KVE
Sbjct: 241 DLGPRGPELAGLQAERDVDILNHVFDDVESFVSRLQKSAEATRVLEHRERGRRTRRRAAGEGLLTLRAKPPTEAEYTDVLQKIKYAFSLLARLRGNIANPSSPELLHFLFGPLQMIVNTSGGPEFAK--SVRRPHLTLEAVTLLRDNVTPGENELWTSLGDSWTCPGVELPPEEGSPYSPEFYNGW----EPPATDPQGRPWEDPVEKQLQHEKRRR----QQSAPQVAVNGQQDPELET---ESQLEEKARKWVLCN-------YDFQARNGSELSVKHRDVLEVLDDR--RKWWKVRDHQGQEGYVPYNILTPHP------GPQVHRSQSPARHLETSTPPPPPAPAPAPTQVRPQWDSCDSLNSLDPSEKEKFSQMLCVNEELQSRLAQG------RSGPSRVTPGP--RAQEPQLSPRSEASV--VRAWLQTKGFSSGTVEALGVLTGAQLFSLQKEEL-RAVCPEEGARVYSQVTVQRAL-----LEDREKVSELEAVMEKQKKKVE 708
BLAST of Epidermal growth factor receptor kinase substrate 8 vs. UniProt/SwissProt
Match: sp|Q99K30|ES8L2_MOUSE (Epidermal growth factor receptor kinase substrate 8-like protein 2 OS=Mus musculus OX=10090 GN=Eps8l2 PE=1 SV=1) HSP 1 Score: 118.242 bits (295), Expect = 5.235e-26 Identity = 128/497 (25.75%), Postives = 215/497 (43.26%), Query Frame = 2
Query: 578 YSNEKMNKVKEYDSKPRNDDISSRTERNLLLLNYCFDDIEFFLQHLKDQEEAQAILKNTKGKNLNDR--------------LLEGKAKPSTQNAYLTCIEKIKFSLNLLCKLDGKIKNPDSRQXXXXXXXXXXXXGQAYSIYHNGKLSKVKEPLLTEDTVKLLHQCLSKHYHKQWTSWGDNWCKAREKWAGYKEK--YYPEFFNGYQIDLEELMK-----DGIISPIAD--IPRRAVSNAEISHAIFYNQALPMIAQTDILENTVLSSREEDFCRSVTLRNGKLYRVIATFAASKDEELSMSEGEIIEVIESKPDKNWWLCGNMHGQKGYSPNTLLEPFCYIDRSINNFIKSSPESPDYLNVRNIPTVPVSPKRISQIMKDPNSADKVAEANIINEELKKKINTNSNFGGWNSRASFARPGPVVSKKHGQLSINQDSTSEDVQKWLEYKKFSPSDIEKLKIFNGQTLFLLSRDEMVRIVSSEVANRLDSLVKVQKSL 1999
+S + + D +PR ++ R E+ +LN DDIE+F+ L+ EA K LN R +L +A+P ++ ++ C +K K ++NLL KL I+NP + +L+ L L I + V PLL+ D V L L W S G+ W + R +W + Y P+F +G++ L+ L + +G+ S +D P+ +S + H+ ++ + A DI SS + T K +++ F A ELS+ + E++EV+E + WW N GQ GY P +L D + ++ S + Y P SP + N + + + +N+EL KKI+ N R ++P L + +S ++V+ WLE K FS +E L I G LF L+++E+ ++ E +R+ S + VQK+
Sbjct: 232 FSEPGYRRRESQDEEPRAV-LAQRIEKETQILNCTLDDIEWFVARLQKAAEA--------FKQLNQRKKGKKKNKKGPAEGVLTLRARPPSEGEFVDCFQKTKLAINLLAKLQKHIQNPSAAELVHFLFGPLDLIINTCGSPDIAR--SVSSPLLSTDAVSFLRGHLVPKEMTLWESLGETWMRPRSEWPREPQVPLYVPKFRSGWEPPLDVLQEAPWEVEGLASVPSDQLTPKNRLS---VRHSPKHSLSSESQAPEDIAPPG--SSPHANRGYQPTPAMTKYVKILYDFTARNANELSVLKDEVLEVLED--GRQWWKLRNRSGQAGYVPCNILAEARQED--VGAPLEQSGQK--YWG-------PASPTHKLPPIFAGNKEELIHHMDEVNDELMKKISHIKTQPQRNFRVERSQP--------VHLPLTFESGPDEVRAWLEAKAFSARIVENLGILTGPQLFSLNKEELKKVCGEE-GSRVYSQLTVQKAF 690
BLAST of Epidermal growth factor receptor kinase substrate 8 vs. UniProt/SwissProt
Match: sp|Q9H6S3|ES8L2_HUMAN (Epidermal growth factor receptor kinase substrate 8-like protein 2 OS=Homo sapiens OX=9606 GN=EPS8L2 PE=1 SV=2) HSP 1 Score: 117.857 bits (294), Expect = 6.661e-26 Identity = 131/520 (25.19%), Postives = 223/520 (42.88%), Query Frame = 2
Query: 605 KEYDSKPRNDDISSRTERNLLLLNYCFDDIEFFLQHLKDQEEAQAILKNTKGKNLNDR--------------LLEGKAKPSTQNAYLTCIEKIKFSLNLLCKLDGKIKNPDSRQXXXXXXXXXXXXGQAYSIYHNGKLSKVKEPLLTEDTVKLLHQCLSKHYHKQWTSWGDNWCKAREKWAGYKEK--YYPEFFNGYQIDLE---------ELMKDGIISPIADIPRRAVSNAE----ISHAIFYNQALPMIAQTDILENTVLSSREEDFCRSVTLRNGKLYRVIATFAASKDEELSMSEGEIIEVIESKPDKNWWLCGNMHGQKGYSPNTLL---------EPFCYIDRSINNFIKSSPESPDYLNVRNIPTVPVSPKRISQIMKDPNSADKVAEANIINEELKKKINTNSNFGGWNSRASFARPGPVVSKKHGQLSINQDSTSEDVQKWLEYKKFSPSDIEKLKIFNGQTLFLLSRDEMVRIVSSEVANRLDSLVKVQKSLSGFGTLSRRELDEILTK 2050
+E +PR ++ + E+ +LN DDIE+F+ L+ EA K LN R +L +A+P ++ ++ C +KIK ++NLL KL I+NP + +L+ L L I S + V PLL+ D V L L W S G++W + R +W + Y P+F +G++ ++ E + I ++ + R+++ N++ S ALP + SS T K +++ F A ELS+ + E++EV+E + WW + GQ GY P +L PF +++ + P SP + + P+ P + + Q M + +N+EL +KI+ N RA R V + + +S ++V+ WLE K FSP +E L I G LF L+++E+ ++ E R+ S + +QK+ S EL+E++ K
Sbjct: 238 RESQEEPRAV-LAQKIEKETQILNCALDDIEWFVARLQKAAEA--------FKQLNQRKKGKKKGKKAPAEGVLTLRARPPSEGEFIDCFQKIKLAINLLAKLQKHIQNPSAAELVHFLFGPLDLIVNTCSGPDIAR--SVSCPLLSRDAVDFLRGHLVPKEMSLWESLGESWMRPRSEWPREPQVPLYVPKFHSGWEPPVDVLQEAPWEVEGLASAPIEEVSPVSRQSIRNSQKHSPTSEPTPPGDALPPV-----------SSPHTHRGYQPTPAMAKYVKILYDFTARNANELSVLKDEVLEVLED--GRQWWKLRSRSGQAGYVPCNILGEARPEDAGAPF---EQAGQKYW--GPASPTH---KLPPSFPGNKDELMQHMDE------------VNDELIRKIS--------NIRAQPQRHFRVERSQPVSQPLTYESGPDEVRAWLEAKAFSPRIVENLGILTGPQLFSLNKEELKKVCGEE-GVRVYSQLTMQKAFLE-KQQSGSELEELMNK 703
BLAST of Epidermal growth factor receptor kinase substrate 8 vs. UniProt/SwissProt
Match: sp|Q5RC07|ES8L2_PONAB (Epidermal growth factor receptor kinase substrate 8-like protein 2 OS=Pongo abelii OX=9601 GN=EPS8L2 PE=2 SV=1) HSP 1 Score: 115.546 bits (288), Expect = 3.321e-25 Identity = 127/509 (24.95%), Postives = 216/509 (42.44%), Query Frame = 2
Query: 638 ISSRTERNLLLLNYCFDDIEFFLQHLKDQEEAQAILKNTKGKNLNDR--------------LLEGKAKPSTQNAYLTCIEKIKFSLNLLCKLDGKIKNPDSRQXXXXXXXXXXXXGQAYSIYHNGKLSKVKEPLLTEDTVKLLHQCLSKHYHKQWTSWGDNWCKAREKWAGYKEK--YYPEFFNGYQIDLE---------ELMKDGIISPIADIPRRAVSNAE----ISHAIFYNQALPMIAQTDILENTVLSSREEDFCRSVTLRNGKLYRVIATFAASKDEELSMSEGEIIEVIESKPDKNWWLCGNMHGQKGYSPNTLL---------EPFCYIDRSINNFIKSSPESPDYLNVRNIPTVPVSPKRISQIMKDPNSADKVAEANIINEELKKKINTNSNFGGWNSRASFARPGPVVSKKHGQLSINQDSTSEDVQKWLEYKKFSPSDIEKLKIFNGQTLFLLSRDEMVRIVSSEVANRLDSLVKVQKSLSGFGTLSRRELDEILTK 2050
++ + E+ +LN DDIE+F+ L+ EA K LN R +L +A+P ++ ++ C +K K ++NLL KL I+NP + +L+ L L I + V PLL+ D V L L W S G++W + R +W + Y P+F +G++ ++ E + I ++ + R+++ N++ S ALP + SS T K +++ F A ELS+ + E++EV+E + WW + GQ GY P +L PF +++ + P SP + + P+ P + + Q M + +N+EL +KI+ N RA R V + + +S ++V+ WLE K FSP +E L I G LF L+++E+ ++ E R+ S + VQK+ S EL+E++ K
Sbjct: 249 LAQKIEKETQILNCALDDIEWFVARLQKAAEA--------FKQLNQRKKGKKKGKKAPAEGVLTLRARPPSEGEFIDCFQKTKLAINLLAKLQKHIQNPSAAELVHFLFGPLDLIVNTCGGPDIAR--SVSCPLLSRDAVDFLRGHLVPKEMSLWESLGESWMRPRSEWPWEPQVPLYVPKFHSGWEPPMDVLQEAPWEVEGLASAPIEEVSPVSRQSIRNSQKHSPTSEPTPPGDALPPV-----------SSPHTHRGYQPTPAMAKYVKILYDFTARNANELSVLKDEVLEVLED--GRQWWKLRSRSGQAGYVPCNILGEARPEDAGAPF---EQAGQKYW--GPASPTH---KLPPSFPGNKDELMQHMDE------------VNDELIRKIS--------NIRAQPQRHFRVERSQPVSQPLTYESGPDEVRAWLEAKAFSPRIVENLGILTGPQLFSLNKEELKKVCGEE-GVRVYSQLTVQKAFLE-KQQSGSELEELMNK 704
BLAST of Epidermal growth factor receptor kinase substrate 8 vs. TrEMBL
Match: A0A3P8S5V1 (Eps8 like 1b OS=Amphiprion percula OX=161767 PE=4 SV=1) HSP 1 Score: 160.229 bits (404), Expect = 3.701e-38 Identity = 138/497 (27.77%), Postives = 219/497 (44.06%), Query Frame = 2
Query: 647 RTERNLLLLNYCFDDIEFFLQHLKDQEEAQAILKN------TKGKNLNDRLLEGKAKPSTQNAYLTCIEKIKFSLNLLCKLDGKIKNPDSRQXXXXXXXXXXXXGQAYSIYHNGKLSKVKEPLLTEDTVKLLHQCLSKHYHKQWTSWGDNWCKAREKWAGYKEKYYPEFFNGYQIDLEELMKDGIISPIADIPRRAVSNAEISHAIFYNQALPMIAQTDILENTVLSSREEDFCRSVTLRNGKLYRVIATFAASKDEELSMSEGEIIEVIESKPDKNWWLCGNMHGQKGYSPNTLLEPFCYIDRSINN--------------FIKSSPESPDYLNVRNIPTVPVSPKRISQIMKDPNSADKVAEANIINEELKKKINTNSNFGGWNSRASFARPGPVVSKKHGQLSINQDSTSEDVQKWLEYKKFSPSDIEKLKIFNGQTLFLLSRDEMVRIVSSEVANRLDSLVKVQKSLSGFGTLSRR--ELDEILTKRKEKVEI 2071
R ER + +LN+CFDDIE F+ L+ EA +L +K +N + LL KA+P + ++ +K K+ +LL +L I NP S +L+ + + L I + G + V P LT V LL LS+ + WTS G NW R + G Y P F +G++ E L DG + V + A+ Q P +S + + +LY F A ELS+ +GE +EVIES K WW C N Q G+ P +LEP +ID + + F P P +V P P P+ + + SA++ + ++N+EL +++ N + + +P + + ++ S E+V WL K FS + L + G LF L+++E+ R V E R+ S + VQK+L +RR EL+ ++ K+K KV++
Sbjct: 44 RAEREVGILNHCFDDIENFMAKLQQTAEAATVLNQRKKKKKSKKQNGEEDLLTAKARPPPEEEFIDIFQKFKYCFSLLARLKSTIANPSSEELVHHVFKPLDMIVKTTGGPALG--ASVSSPALTSSAVSLLQDSLSEEERQLWTSLGPNWTLPRSQLRGPVAPYTPVFLSGWKP--EALRADGQVW------EDPVESQHKHEALRVQQEQP---------PQPISPPDTHIDETDGPELDRLYSCSYDFIARNSSELSVQQGETLEVIESS--KRWWKCRNRFNQIGFVPFNILEPVAHIDSPVAHRPPPAPALPPLAKTFSTVPPSPPALPSVP--PESPQRPRSLPGYNQHMASAEETDKVMLVNDELLQRLT--------NGKVNLNKPLVIPRSSETSVPLDYHSPPEEVADWLRGKGFSEPTVSCLGVLTGAQLFSLNKEEL-RAVIPEEGARVYSQLTVQKALL---EDARRATELEAVMEKQKMKVDL 505
BLAST of Epidermal growth factor receptor kinase substrate 8 vs. TrEMBL
Match: A0A3Q1BX77 (Eps8 like 1b OS=Amphiprion ocellaris OX=80972 PE=4 SV=1) HSP 1 Score: 159.844 bits (403), Expect = 5.243e-38 Identity = 138/498 (27.71%), Postives = 219/498 (43.98%), Query Frame = 2
Query: 647 RTERNLLLLNYCFDDIEFFLQHLKDQEEAQAILKN-------TKGKNLNDRLLEGKAKPSTQNAYLTCIEKIKFSLNLLCKLDGKIKNPDSRQXXXXXXXXXXXXGQAYSIYHNGKLSKVKEPLLTEDTVKLLHQCLSKHYHKQWTSWGDNWCKAREKWAGYKEKYYPEFFNGYQIDLEELMKDGIISPIADIPRRAVSNAEISHAIFYNQALPMIAQTDILENTVLSSREEDFCRSVTLRNGKLYRVIATFAASKDEELSMSEGEIIEVIESKPDKNWWLCGNMHGQKGYSPNTLLEPFCYIDRSINN--------------FIKSSPESPDYLNVRNIPTVPVSPKRISQIMKDPNSADKVAEANIINEELKKKINTNSNFGGWNSRASFARPGPVVSKKHGQLSINQDSTSEDVQKWLEYKKFSPSDIEKLKIFNGQTLFLLSRDEMVRIVSSEVANRLDSLVKVQKSLSGFGTLSRR--ELDEILTKRKEKVEI 2071
R ER + +LN+CFDDIE F+ L+ EA +L +K +N + LL KA+P + ++ +K K+ +LL +L I NP S +L+ + + L I + G + V P LT V LL LS+ + WTS G NW R + G Y P F +G++ E L DG + V + A+ Q P +S + + +LY F A ELS+ +GE +EVIES K WW C N Q G+ P +LEP +ID + + F P P +V P P P+ + + SA++ + ++N+EL +++ N + + +P + + ++ S E+V WL K FS + L + G LF L+++E+ R V E R+ S + VQK+L +RR EL+ ++ K+K KV++
Sbjct: 44 RAEREVGILNHCFDDIENFMAKLQQTAEAATVLNQRKKKKKKSKKQNGEEDLLTAKARPPPEEEFIDIFQKFKYCFSLLARLKSTIANPSSEELVHHVFKPLDMIVKTTGGPALG--ASVSSPALTSSAVSLLQDSLSEEERQLWTSLGPNWTLPRSQLRGPVAPYTPVFLSGWKP--EALRADGQVW------EDPVESQHKHEALRVQQEQP---------PQPISPPDTHIDETDGPELDRLYSCSYDFIARNSSELSVQQGETLEVIESS--KRWWKCRNRFNQIGFVPFNILEPVAHIDSPVAHRPPPAPALPPLAKTFSTVPPSPPALPSVP--PESPQRPRSLPGYNQHMASAEETDKVMLVNDELLQRLT--------NGKVNLNKPLVIPRSSETSVPLDYHSPPEEVADWLRGKGFSEPTVSCLGVLTGAQLFSLNKEEL-RAVIPEEGARVYSQLTVQKALL---EDARRATELEAVMEKQKMKVDL 506
BLAST of Epidermal growth factor receptor kinase substrate 8 vs. TrEMBL
Match: A0A482W168 (Epidermal growth factor receptor kinase substrate 8 OS=Asbolus verrucosus OX=1661398 GN=BDFB_000187 PE=4 SV=1) HSP 1 Score: 162.54 bits (410), Expect = 9.566e-38 Identity = 185/721 (25.66%), Postives = 310/721 (43.00%), Query Frame = 2
Query: 257 ERQVLVIRRWLDQVILEEFKLALI---TNVASHQQVPDNNYLSNILTFNTQIKTSSNV--LTETHIFQ---------LED-SNLHMVNYLASDIRSAIESATNLNPKNTPIKVLPSNNKRNSYSNEKMNKVKEYDSKPRNDDISSRT----ERNLLLLNYCFDDIEFFLQHLKDQEEAQAILKNTKGK------NLNDRLLEGKAKPSTQNAYLTCIEKIKFSLNLLCKLDGKIKNPDSRQXXXXXXXXXXXXGQA-YSIYHNGKLS-KVKEPLLTEDTVKLLHQCLSKHYHKQWTSWGDNWCKAREKWAGYKEKYYPEFFNGYQID---LEELMK--------DGIISPIADIPRRAVSNAEI--------SH--AIFYNQALPM----IAQTDILENTV---------LSSREEDFCRSVTLRNGKLYRVIATFAASKDEELSMSEGEIIEVIESKPDKNWWLCGNMHGQKGYSPNTLLEPF-----------CYIDRSINNFIKS-----------SPESPDYLN----------VRNIPTV-----------------PVSPKRISQIMKDPNSADKVAEANIINEELKKKINTNSNFGGWNSRASFARP----GPVVSKKHGQLSINQDSTSEDVQKWLEYKKFSPSDIEKLKIFNGQTLFLLSRDEMVRIVSSEVANRLDSLVKVQKSLSGFGTLSRRELDEILTKRKEKVEITE 2077
+R ++I + ++E F I T SH + +NIL F I T+SN E HIFQ +ED L M L +++I ++ P N + P+ + R+ + ++ + NDD SS T ER++ +LN+CFDDIE F+ L+ A L+ + ++ D +L + KP + ++ +K K S NLL KL I +P++ +L+ L L I +A + Y + +L KV PLLT + V LL C++ + W S G+ W R++W G+ Y+P F +G+ D ++EL +G +D SN EI SH I + LP ++DI +++ +E+F + R + +V A+ D+EL++ GE +E+++ + WW N GQ + P+T++ PF Y + N ++ SP +P+++N VR V PV+P ++ + + P+ + + + +EL N S R + ++ ++ I+Q ST E+VQ WL+ K F P K K G LF ++++ RI + RLDS +K+QKS+SG+ T+ EL IL K +EK+E +
Sbjct: 71 DRSWVLIMDYETGSVMERFPANSIQEPTAFTSHDPM---EMYNNILVF---IVTNSNQSHPPEMHIFQCQSISAQDLVEDLKQLRMGKTLTRSRKTSIPPPSHKPPPNV---INPTRDPRDYHGSDS-------ELTANNDDSSSTTSEKYERDVTILNHCFDDIEKFIARLQHAAAAARELERRRRSRKSKKRDMGDGMLTMRTKPPPEKEFIDIFQKFKLSFNLLAKLKAHIHDPNAPELVHFLFTPLALIVEASHDTYSDSQLPRKVVSPLLTREAVNLLMNCVTSKETELWHSLGNAWLIPRDQWKGHVPPYHPIFMDGWSPDYPVVDELETNNDNKHYIEGQYG--SDYNDYDTSNQEIFMYEKGSDSHHQKIEPERDLPPNLGESTRSDISVDSIERNGGEDRGFGRSQENFLDDLQARGANIVQVTYPRTANNDKELTVVRGEYLEILDDS--RKWWKARNSRGQVAHVPHTIVTPFHSGGNDIFNNPLYTTHNYRNSHRADSPLDRFSGGHSPSAPEHVNPPVSATSADWVRKERLVNDGPPPPPPPPPPMISNPVTP--VTTLKRSPSIKSTTTQGDRMQDEL-------------NLVLSMVREKRYKSHIEVRQTPEVYIDQKSTPEEVQNWLKAKDFEPKICAKFKGLAGHNLFDFQKNQLERICGPKEGARLDSQLKIQKSVSGYQTVRSSELKAILAKAREKIEAAD 756
BLAST of Epidermal growth factor receptor kinase substrate 8 vs. TrEMBL
Match: A0A1S3JAS1 (epidermal growth factor receptor kinase substrate 8 isoform X6 OS=Lingula unguis OX=7574 GN=LOC106171223 PE=4 SV=1) HSP 1 Score: 162.925 bits (411), Expect = 1.283e-37 Identity = 160/554 (28.88%), Postives = 245/554 (44.22%), Query Frame = 2
Query: 626 RNDD----ISSRTERNLLLLNYCFDDIEFFLQHLKDQEEA-------QAILKNTKGKNLNDRLLEGKAKPSTQNAYLTCIEKIKFSLNLLCKLDGKIKNPDSRQXXXXXXXXXXXXGQAYSIYHNGK---LSKVKEPLLTEDTVKLLHQCLSKHYHKQWTSWGDNWCKAREKWAGYKEKYYPEFFNGYQIDLEELMKD-----GIISP-------IADIPRRAVS-------------NAEISHAIFYNQALPMIAQTDILENTVLSSREED--FCRSVTLRNGKLYRVIATFAASKDEELSMSEGEIIEVIESKPDKNWWLCGNMHGQKGYSPNTLLEPF-----------CYIDRSINNFIKSSPESPDYLNV---------------RNIPTVPVSPKRISQIMKDPNSADKVAEANIINEELKKKINTNSNFGGWNSR-ASFARPGPVVSKKHGQLSINQDSTSEDVQKWLEYKKFSPSDIEKLKIFNGQTLFLLSRDEMVRIVSSEVANRLDSLVKVQKSLSGFGTL--SRRELDEILTKRKEKVEITE 2077
R DD +S RTER++ LLN+CFDDIE F+ L+ EA Q +K K + + +L +A+P ++ K K S NLL KL I +P++ +L+ L L + +A +G S+V PLLT +LL CL+ W S G+ W R+ W GY Y P F++G+Q M+D G P A P+R S N + H + P + E VLS E+ F R + + K+Y V+ + +EL++S+GEI+EV++ +NWW N G G++P T+L+ + + +R +F +S+ P R T PK ++ K A + ++ ELK ++ N NSR S RP V + ST+E+V +WL+ K F + KL ++G++LF S+ E+ R++ E RL S V VQK+LSGF EL IL KRK++ + +E
Sbjct: 290 REDDNDSVVSERTERDVQLLNHCFDDIEKFVARLQFAAEAYKELSRRQKNRGKSKKKVMGEGMLTMRARPPPPQDFIDIFAKFKLSFNLLAKLKAHIHDPNAPELVHFLFTPLSLVVEASKDPRHGTPDLASQVISPLLTVHARELLLNCLTSKEIDLWMSLGEPWSVHRDAWKGYVPPYVPRFYDGWQPGGP--MEDPTYQYGHGGPNYSGQGYGAPPPQRGESFRDVQRSNSLQYGNRQAQHEAMARRQEPQLPP----EPRVLSFEEKQKIFLRELRSKGAKVYEVMHERSGRNAKELTVSKGEILEVLDD--GRNWWKLRNSEGTVGHAPYTILKKYDDDSDPRGHDSSFDERDRRDFGRSNGARPPPPPPGPPPPPVNGNWKQANRQEETKKPKPKE----NEEKTIIHKAASKDDLHNELKNQLTKGKN---RNSRPVSHGRPISAV-------YLTMYSTTEEVGEWLQSKNFPERVVYKLDEYDGESLFKASQAELERLIGKEQGQRLASQVLVQKNLSGFKDTNSGNNELAAILQKRKQRADSSE 821
BLAST of Epidermal growth factor receptor kinase substrate 8 vs. TrEMBL
Match: H2UXA0 (Eps8 like 1b OS=Takifugu rubripes OX=31033 GN=LOC101074325 PE=4 SV=2) HSP 1 Score: 160.999 bits (406), Expect = 1.543e-37 Identity = 138/500 (27.60%), Postives = 226/500 (45.20%), Query Frame = 2
Query: 647 RTERNLLLLNYCFDDIEFFLQHLKDQEEAQAILKN--------TKGKNLNDRLLEGKAKPSTQNAYLTCIEKIKFSLNLLCKLDGKIKNPDSRQXXXXXXXXXXXXGQAYSIYHNGKLSKVKEPLLTEDTVKLLHQCLSKHYHKQWTSWGDNWCKAREKWAGYKEKYYPEFFNGYQIDLEELMKDGII--SPIADIPRRAVSNAEISHAIFYNQALPMIAQTDILENTVLSSREEDFCRSVTLRNGKLYRVIATFAASKDEELSMSEGEIIEVIESKPDKNWWLCGNMHGQKGYSPNTLLEPFCYIDRSINNFIKSS-------------PESPDYLNVRNIPTVPVSPKRISQIMKDPNSADKVAEANIINEELKKKINTNSNFGGWNSRASFARPGPVVSKKHGQLSINQDSTSEDVQKWLEYKKFSPSDIEKLKIFNGQTLFLLSRDEMVRIVSSEVANRLDSLVKVQKSLSGFGTLSRR--ELDEILTKRKEKVEI 2071
R ER + +LN+CFDDIE F+ L+ EA +L +K ++ + LL KA+P + ++ +K K+ +LL +L I NP + L+ + + L + + G V P LT V LL LS+ + WTS G NW + G Y P F++G++ E L DG + P+ + A+ P I + D + +LY + F A ELS+ +GE +EV+ES K WW C N Q G+ P +L+P +++ +++ S+ P SP L+ + P P S SQ + P + D +A ++N+EL ++ N +A+ +P + + ++ DS+ E+V +WL K FS + L + G LF L++DE+ R V E R+ S + VQK+L +RR EL+E++ K+K KV++
Sbjct: 189 RAEREVGILNHCFDDIENFMAKLQQTAEAAMVLNQRKKKNKKKSKKQSSEEDLLTAKARPPPEEEFVDIFQKFKYCFSLLARLKSAISNPSAEDLVHHVFKPLDMMVKTTGGPAMG--GSVSSPALTNAAVTLLQDNLSEEERQLWTSLGPNWTLPCSQLRGPVAPYVPVFYDGWKP--ETLRPDGQVWEDPVESQHKHEDLQAKREQQQPPQPVRPAITSSS------------DATDGSPVPPERLYSCMYDFIARNSTELSVQQGETLEVLESS--KRWWKCRNYFNQVGFVPFNILQPMTHVESPVSSRPPSAPAPPPLPKTFSVVPPSPPVLHPSHSPQRPRSLPPYSQNI--PAADDTENKAMLVNDELLHRLT--------NGKANLNKPLVIQRSSETSIPLDYDSSPEEVGEWLRGKGFSEPTVTCLGVLTGAQLFSLNKDEL-RAVIPEEGARVYSQLTVQKALL---EDARRATELEEVMEKQKMKVDL 656
BLAST of Epidermal growth factor receptor kinase substrate 8 vs. Ensembl Cavefish
Match: eps8l1a (eps8 like 1a [Source:ZFIN;Acc:ZDB-GENE-050306-14]) HSP 1 Score: 128.257 bits (321), Expect = 9.680e-31 Identity = 130/510 (25.49%), Postives = 211/510 (41.37%), Query Frame = 2
Query: 650 TERNLLLLNYCFDDIEFFLQHLKDQEEAQAILKNTKGKNLN------------DRLLEGKAKPSTQNAYLTCIEKIKFSLNLLCKLDGKIKNPDSRQXXXXXXXXXXXXGQAYSIYHNGKLSKVKEPLLTEDTVKLLHQCLSKHYHKQWTSWGDNWCKAREKWAGYKEKYYPEFFNGYQIDLEELMKDGIISPIADIPRRAVSNAEISHAIFYNQALPMIAQTDILENTVLSSREEDFCRSVTLRNGKLYRVIATFAASKDEELSMSEGEIIEVIESKPDKNWWLCGNMHGQKGYSPNTLLEPFCYIDRSINNFIKSSPESPDYLNVRNIPT--VPVSPK---RISQIMKD----------------PNSADKVAEANIINEELKKKINTNSNFGGWNSRASFARPGPVVSKKHGQLSINQDSTSEDVQKWLEYKKFSPSDIEKLKIFNGQTLFLLSRDEMVRIVSSEVANRLDSLVKVQKSLSGFGTLSR----RELDEILTKRKEKVE 2068
+R + LLN+CF D+E F+ L+ A+ ++ +K K D + E + ++ +KIK+S +LL +L +I P S +L+ L L + + + V P LT V LL Q LS+ + W S G NW ++ + Y P F +G+Q + + P+ E H TD L + + EE+ +LYR F A ELS+ GE ++V+ES K WW C N + Q G+ P+ +LEP + + PD V P+ +P+SP R S ++ P D ++N EL +++ +R SF V++ + S+N S +VQ WL+ K FS + L I +G LF L+++E+ VS + R+ S + +QK+L L + ELD ++ K+K KV+
Sbjct: 60 AQREVDLLNHCFADVETFMGRLQQAANARTAVEQSKKKKKAKKDNSKKKKQQYDLMAEEVPSGPSGQEFVDIFQKIKYSFSLLGRLKNEISKPSSEELLHHLFVPLDLL--VKTTGGPDMAAGVSSPALTSGAVGLLQQNLSQEERELWESLGPNWTQSYSQQTNPVSPYTPVFLDGWQPEACDASGQAFEDPV-----------ESQHKYEAQPESQQFDSTDALPPNLPT--EENVENPPPSEGERLYRCSYDFVARNSSELSVLHGETLQVLES--SKRWWKCRNNYDQIGFVPSNILEPVNHTE-------------PDSRVVMRHPSTRIPLSPPGGGRFSYVVPSSSGEIYSHNETRPHSMPPIGDDGERVTLMNNELAERLANG------RTRPSF------VTRTNETASLNYHSAPGEVQDWLKGKGFSEHTVNSLGILSGAQLFSLNKEELC-TVSPQEGGRVYSQLTIQKAL-----LEKVNKATELDAVMKKQKMKVD 521
BLAST of Epidermal growth factor receptor kinase substrate 8 vs. Ensembl Cavefish
Match: eps8l2 (EPS8 like 2 [Source:NCBI gene;Acc:103026465]) HSP 1 Score: 108.997 bits (271), Expect = 4.554e-24 Identity = 154/640 (24.06%), Postives = 263/640 (41.09%), Query Frame = 2
Query: 281 RWLDQVILEEFKLALITNVASHQQVPDNNYLSNILTFNTQIKTSSNVLTETHIFQLEDSNLHMVNYLASDIRSAI---ESATNLNPKNTPI----------KVLPSNNKRNSYSNEKMNKVKEYDSK-------PRNDD-----ISSRTERNLLLLNYCFDDIEFFLQHLKDQEEAQAIL------KNTKGKNLNDRLLEGKAKPSTQNAYLTCIEKIKFSLNLLCKLDGKIKNPDSRQXXXXXXXXXXXXGQAYSIYHNGKLSKVKEPLLTEDTVKLLHQCLSKHYHKQWTSWGDNWCKAREKWAGYK--EKYYPEFFNGYQIDLE-------ELMKDGIISPIADIPRRAVSNAEISHAIFYNQALPMIAQTDILENTVLSSREEDFCRSVTLRNGKLYRVIATFAASKDEELSMSEGEIIEVIESKPDKNWWLCGNMHGQKGYSPNTLL-----EPFCYIDRSINNFIKSSPESPDYLNVRNIPTVPVSPKRISQIMKDPNSADKVAEANIINEELKKKINTNSNFGGWNSRASFARPGPVVSKKHGQLSINQDSTSEDVQKWLEYKKFSPSDIEKLKIFNGQTLFLLSRDEMVRIVSSEVANRLDSLVKVQKSLSGFGTLSRRELDEILTKRKEKV 2065
+ LD +EE + + V Q V + ++L Q K + H F ++ +V+ +DI SA+ ++ N+ P+ + ++P + + S K +V D K P+ D ++ E+++ +LN DDIE F+ L+ EA A L + K + + +L +AKP ++ ++ ++K+K S NLL KL I+NP + +L+ L L + Q S + P L+ D V L L+ + GD W + R W + Y P+F NG++ +E E G +SP S++E F+ + S F +R K ++ F A ELS+ + E++EVIE DK WW N GQ GY P +L E +D + + K S S L + +P SP+ + + + + +N+EL K+I + + AR V + ++ +S+ +V WL K FS ++ L + +G LF L +DE+ + E A R+ S + VQK+ + EL I+ ++KEK+
Sbjct: 96 KLLDCDTMEELENFPLPTVHHSQTVLNKLRYPSVLLLVCQDKEQHK--PDIHFFHCDEVEADIVH---ADIDSALGDNKNGKNMRPQTLKMNQEKMKRQRETIIPPSESKGSAPAVK-GRVAAMDMKSVERRVSPQQDPESYEKLAQYIEKDVQILNCALDDIEIFVARLQKAAEAFAQLNQRNKSRKNKKRGPAEGMLTLRAKPPSEVEFIDSLQKLKLSFNLLAKLKKHIQNPSASELVHFLFGPLELVLQ--SCGSPDLPRSIISPHLSRDAVDFLRGHLTPKEMTIFELLGDGWTRPRADWPREQCAPLYIPKFRNGWEPPVELFRTSPWETECSGPMSP---------SSSEYRKKEFFG-------------SQSSLSSNGSFTAPSPIR--KYAKIRYHFVARNANELSVLQDEVLEVIED--DKQWWKLRNRSGQAGYVPYNILDVITPEELRVMDPAYSQSYKGSSPS-GSLGRGDSFDMPRSPR---------DKDIRTQQMDEVNDELLKRITASKS-------QPQARNFKVERHSTRAIPLSFNSSPAEVATWLNGKGFSKPTVDCLGVLSGAQLFSLEKDELKAVCGDEGA-RVYSQITVQKAQLE-KSRGDSELQNIMKRQKEKI 682
BLAST of Epidermal growth factor receptor kinase substrate 8 vs. Ensembl Cavefish
Match: eps8l2 (EPS8 like 2 [Source:NCBI gene;Acc:103026465]) HSP 1 Score: 108.227 bits (269), Expect = 5.794e-24 Identity = 154/641 (24.02%), Postives = 266/641 (41.50%), Query Frame = 2
Query: 281 RWLDQVILEEFKLALITNVASHQQVPDNNYLSNILTFNTQIKTSSNVLTETHIFQLEDSNLHMVNYLASDIRSAI---ESATNLNPKNTPI----------KVLPSNNKRNSYSNEKMNKVKEYDSK-------PRND-----DISSRTERNLLLLNYCFDDIEFFLQHLKDQEEAQAIL------KNTKGKNLNDRLLEGKAKPSTQNAYLTCIEKIKFSLNLLCKLDGKIKNPDSRQXXXXXXXXXXXXGQAYSIYHNGKLSK-VKEPLLTEDTVKLLHQCLSKHYHKQWTSWGDNWCKAREKWAGYK--EKYYPEFFNGYQIDLE-------ELMKDGIISPIADIPRRAVSNAEISHAIFYNQALPMIAQTDILENTVLSSREEDFCRSVTLRNGKLYRVIATFAASKDEELSMSEGEIIEVIESKPDKNWWLCGNMHGQKGYSPNTLL-----EPFCYIDRSINNFIKSSPESPDYLNVRNIPTVPVSPKRISQIMKDPNSADKVAEANIINEELKKKINTNSNFGGWNSRASFARPGPVVSKKHGQLSINQDSTSEDVQKWLEYKKFSPSDIEKLKIFNGQTLFLLSRDEMVRIVSSEVANRLDSLVKVQKSLSGFGTLSRRELDEILTKRKEKV 2065
+ LD +EE + + V Q V + ++L Q K + H F ++ +V+ +DI SA+ ++ N+ P+ + ++P + + S K +V D K P+ D ++ E+++ +LN DDIE F+ L+ EA A L + K + + +L +AKP ++ ++ ++K+K S NLL KL I+NP + +L+ L L + Q+ + L + + P L+ D V L L+ + GD W + R W + Y P+F NG++ +E E G +SP S++E F+ + S F +R K ++ F A ELS+ + E++EVIE DK WW N GQ GY P +L E +D + + K S S L + +P SP+ + + + + +N+EL K+I + + AR V + ++ +S+ +V WL K FS ++ L + +G LF L +DE+ + E A R+ S + VQK+ + EL I+ ++KEK+
Sbjct: 73 KLLDCDTMEELENFPLPTVHHSQTVLNKLRYPSVLLLVCQDKEQHK--PDIHFFHCDEVEADIVH---ADIDSALGDNKNGKNMRPQTLKMNQEKMKRQRETIIPPSESKGSAPAVK-GRVAAMDMKSVERRVSPQQDPESYEKLAQYIEKDVQILNCALDDIEIFVARLQKAAEAFAQLNQRNKSRKNKKRGPAEGMLTLRAKPPSEVEFIDSLQKLKLSFNLLAKLKKHIQNPSASELVHFLFGPLELVLQSCG---SPDLPRSIISPHLSRDAVDFLRGHLTPKEMTIFELLGDGWTRPRADWPREQCAPLYIPKFRNGWEPPVELFRTSPWETECSGPMSP---------SSSEYRKKEFFG-------------SQSSLSSNGSFTAPSPIR--KYAKIRYHFVARNANELSVLQDEVLEVIED--DKQWWKLRNRSGQAGYVPYNILDVITPEELRVMDPAYSQSYKGSSPS-GSLGRGDSFDMPRSPR---------DKDIRTQQMDEVNDELLKRITASKS-------QPQARNFKVERHSTRAIPLSFNSSPAEVATWLNGKGFSKPTVDCLGVLSGAQLFSLEKDELKAVCGDEGA-RVYSQITVQKAQLE-KSRGDSELQNIMKRQKEKI 659
BLAST of Epidermal growth factor receptor kinase substrate 8 vs. Ensembl Cavefish
Match: eps8l2 (EPS8 like 2 [Source:NCBI gene;Acc:103026465]) HSP 1 Score: 108.227 bits (269), Expect = 7.941e-24 Identity = 157/641 (24.49%), Postives = 266/641 (41.50%), Query Frame = 2
Query: 281 RWLDQVILEEFKLALITNVASHQQVPDNNYLSNILTFNTQIKTSSNVLTETHIFQLEDSNLHMVNYLASDIRSAI---ESATNLNPKNTPI----------KVLPSNNKRNSYSNEKMNKVKEYDSK-------PRND-----DISSRTERNLLLLNYCFDDIEFFLQHLKDQEEAQAIL--KNTKGKNLNDRLLEG----KAKPSTQNAYLTCIEKIKFSLNLLCKLDGKIKNPDSRQXXXXXXXXXXXXGQAYSIYHNGKLSK-VKEPLLTEDTVKLLHQCLSKHYHKQWTSWGDNWCKAREKWAGYK--EKYYPEFFNGYQIDLE-------ELMKDGIISPIADIPRRAVSNAEISHAIFYNQALPMIAQTDILENTVLSSREEDFCRSVTLRNGKLYRVIATFAASKDEELSMSEGEIIEVIESKPDKNWWLCGNMHGQKGYSPNTLL-----EPFCYIDRSINNFIKSSPESPDYLNVRNIPTVPVSPKRISQIMKDPNSADKVAEANIINEELKKKINTNSNFGGWNSRASFARPGPVVSKKHGQLSINQDSTSEDVQKWLEYKKFSPSDIEKLKIFNGQTLFLLSRDEMVRIVSSEVANRLDSLVKVQKSLSGFGTLSRRELDEILTKRKEKV 2065
+ LD +EE + + V Q V + ++L Q K + H F ++ +V+ +DI SA+ ++ N+ P+ + ++P + + S K +V D K P+ D ++ E+++ +LN DDIE F+ L+ EA A L +N KN EG +AKP ++ ++ ++K+K S NLL KL I+NP + +L+ L L + Q+ + L + + P L+ D V L L+ + GD W + R W + Y P+F NG++ +E E G +SP S++E F+ + S F +R K ++ F A ELS+ + E++EVIE DK WW N GQ GY P +L E +D + + K S S L + +P SP+ + + + + +N+EL K+I + + AR V + ++ +S+ +V WL K FS ++ L + +G LF L +DE+ + E A R+ S + VQK+ + EL I+ ++KEK+
Sbjct: 98 KLLDCDTMEELENFPLPTVHHSQTVLNKLRYPSVLLLVCQDKEQHK--PDIHFFHCDEVEADIVH---ADIDSALGDNKNGKNMRPQTLKMNQEKMKRQRETIIPPSESKGSAPAVK-GRVAAMDMKSVERRVSPQQDPESYEKLAQYIEKDVQILNCALDDIEIFVARLQKAAEAFAQLNQRNKSRKNKKRGPAEGMLTLRAKPPSEVEFIDSLQKLKLSFNLLAKLKKHIQNPSASELVHFLFGPLELVLQSCG---SPDLPRSIISPHLSRDAVDFLRGHLTPKEMTIFELLGDGWTRPRADWPREQCAPLYIPKFRNGWEPPVELFRTSPWETECSGPMSP---------SSSEYRKKEFFG-------------SQSSLSSNGSFTAPSPIR--KYAKIRYHFVARNANELSVLQDEVLEVIED--DKQWWKLRNRSGQAGYVPYNILDVITPEELRVMDPAYSQSYKGSSPS-GSLGRGDSFDMPRSPR---------DKDIRTQQMDEVNDELLKRITASKS-------QPQARNFKVERHSTRAIPLSFNSSPAEVATWLNGKGFSKPTVDCLGVLSGAQLFSLEKDELKAVCGDEGA-RVYSQITVQKAQLE-KSRGDSELQNIMKRQKEKI 684
BLAST of Epidermal growth factor receptor kinase substrate 8 vs. Ensembl Cavefish
Match: eps8a (epidermal growth factor receptor pathway substrate 8 [Source:NCBI gene;Acc:103047627]) HSP 1 Score: 99.7525 bits (247), Expect = 3.294e-21 Identity = 95/359 (26.46%), Postives = 161/359 (44.85%), Query Frame = 2
Query: 563 NKRNSYSNEKMNKVKEYDSKPRNDDISSRTERNLLLLNYCFDDIEFFLQHLKDQEEA------QAILKNTKGKNLNDRLLEGKAKPSTQNAYLTCIEKIKFSLNLLCKLDGKIKNPDSRQXXXXXXXXXXXXGQAYSIYHNGKLSKVKE---PLLTEDTVKLLHQCLSKHYHKQWTSWGDNWCKAREKWAGYKEKYYP----EFFNGYQIDL-----EELMKDGIISPIADIPRRAVSNAEISHAIFYNQALPMIAQTDILENTVLSSREEDFCRSVTLRNGK-----LYRVIATFAASKDEELSMSEGEIIEVIESKPDKNWWLCGNMHGQKGYSPNTLLEPFCYIDRSINNFIKSSP 1570
N++ Y +K E+D P + ++R +R++ +LN+ DDIE F+ L+ EA + K +K K + +L +AKP Q ++ C +K K + NLL KL I+NP + L+ L L + I+ +G + K PLLT + + LH + W + GD W K R +W K+ Y+P F +G++ + ++L + A+I R+ E+S + + QA R +DF + +G+ + F A ELS+ + E++EV++ + K WW N G GY PN +LE I R+++ + P
Sbjct: 240 NEQQDY--DKQRPYGEHDESP--EMTAARVDRDVQILNHILDDIEHFVTKLQKAAEAFNELSKRKKSKKSKKKGPGEGMLTLRAKPPGQEEFVDCFQKFKHAFNLLGKLKNHIQNPSAVDLVHFLFTPLRMV-----IHTSGGVDLAKSVVVPLLTREAIDFLHSAGTPEERHLWVTLGDGWTKCRLEWP--KDHYFPPHTLRFRDGWEPPVLVSREQDLTQLAETLAQAEIHRQ----EEVSRRLHHEQA-----------------RVQDFPIADGSYDGRGQPRNFAKSKYDFVARNGTELSVVKDEVVEVMDDR--KQWWKVRNATGATGYVPNNILE----ISRAVDMTGRGEP 560
BLAST of Epidermal growth factor receptor kinase substrate 8 vs. Ensembl Sea Lamprey
Match: ENSPMAT00000010635.1 (pep scaffold:Pmarinus_7.0:GL476906:83540:115491:1 gene:ENSPMAG00000009631.1 transcript:ENSPMAT00000010635.1 gene_biotype:protein_coding transcript_biotype:protein_coding) HSP 1 Score: 73.1738 bits (178), Expect = 1.189e-13 Identity = 78/286 (27.27%), Postives = 120/286 (41.96%), Query Frame = 2
Query: 647 RTERNLLLLNYCFDDIEFFLQHLKDQEEAQAILKNTKGKNL----------NDRLLEGKAKPSTQNAYLTCIEKIKFSLNLLCKLDGKIKNPDSRQXXXXXXXXXXXXGQAYSIYHNGKLSKVK---EPLLTEDTVKLLHQCLSKHYHKQWTSWGDNWCKAREKWAGYK--EKYYPEF-------FNGYQIDLEELMKDGIISPIADIPRRAVSNAEISHAIFYNQALPMIAQTDILENTVLSS-REEDFCRSVTLRNGKLYRVIATFAASKDEELSMSEGEIIEV 1435
R +R+ +LN+ FD+IE F+ L Q+ AQA N GK D +L ++KP ++ ++K K+ NLL +L G I NP + ++I L L I ++ G L V+ PLLT + +L+ + K W S G+ W R +W K Y P F FN I D +P+ PRR I LP+ + + + S R +D S ++ R TF A E+S+ + +I+EV
Sbjct: 248 RVQRDTEILNHLFDEIEGFVAKL--QKAAQAF--NELGKRKKQKRSKKKKNGDGILTLRSKPPPPEEFVDILQKFKYGFNLLARLKGIIDNPSAEEMITSLFPPLQMI-----LHACGGLDMVRCVASPLLTRQAIDILNTSTNPEQRKLWLSLGNAWSVTRAEWPADKPLPSYIPRFPNWEPERFNVPPIAHAHDSPDA--APMPSSPRR----------IAPETQLPITVPSSLRHHLAASGPRRDDDAHS-----KRMARASYTFTARNKNEISVEKDDILEV 507
BLAST of Epidermal growth factor receptor kinase substrate 8 vs. Ensembl Sea Lamprey
Match: ENSPMAT00000001720.1 (pep scaffold:Pmarinus_7.0:GL477470:1323:5557:1 gene:ENSPMAG00000001552.1 transcript:ENSPMAT00000001720.1 gene_biotype:protein_coding transcript_biotype:protein_coding) HSP 1 Score: 50.8322 bits (120), Expect = 3.691e-7 Identity = 69/268 (25.75%), Postives = 120/268 (44.78%), Query Frame = 2
Query: 779 LLEGKAKPSTQNAYLTCIEKIKFSLNLLCKLDGKIKNPDSRQXXXXXXXXXXXXGQAYSIYHNGKLSK-VKEPLLTEDTVKLLHQCLSKHYHKQWTSWGDNW------------CKAREKWAGYKEK------YYPEFFNGYQIDLEELMKDGIISPIADIPRRAVSNAEISHAIFYNQALPMIAQTDILENTVLSSREEDFCRSVTLRNGKLYRVIATFAASKDEELSMSEGEIIEVIESKPDKNWW-LCGNMHGQKGYSPNTLLEP 1522
+L +AKP T+ ++ C++KIKFS NLL +L + +P + + + L + L ++ Q +L++ V PLLT D + LL S W+S G+ W C R + + K Y P F +G+Q +++ + + +AE S A P QT I + + + + CR + R + + A E+S+ G+I++V++S ++WW + N Q GY P+ +LEP
Sbjct: 12 VLTLRAKPPTEEEFIECLQKIKFSFNLLARLKDHLHDPTAEEHVQSLFQTLTRVVQESG---GPELAETVVSPLLTRDALLLLAPSTSGDGIHLWSSLGEAWSTPRSGTNPSSLCSQRRQSSSAWNKPAPVPHYVPVFRSGWQPHVQK--------------KVSFVDAEPSQP--SPSAWPP-GQTRI--DPIYEAEIDCSCRG-------MARCLYDYVARSSSEISVLAGDILQVLDST--RSWWKVASNGAQQMGYVPHNILEP 248
BLAST of Epidermal growth factor receptor kinase substrate 8 vs. Ensembl Nematostella
Match: EDO29184 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7T4C9]) HSP 1 Score: 56.225 bits (134), Expect = 3.187e-8 Identity = 54/204 (26.47%), Postives = 97/204 (47.55%), Query Frame = 2
Query: 293 QVILEEFKLALITNVASHQQVPDNNYLSNILTFNTQIKTSSNVLTETHIFQLEDSNLHMVNYLASDIRSAIESATNLNPKNTPIKVLPSNNKRNSYSNEKMNKVKEYDSKPRNDDISSRTERNLLLLNYCFDDIEFFLQHLKDQEEAQAILKNTKGKNLNDRLLEGKAKPSTQNAYLTCIEKIKFSLNLLCKLDGKIKNPDSRQ 904
Q ++E + LA I V Q + D+ L+++L F+T + + TH+FQ + + + + A + A S + + P +V P + + E N ++ + +RT R++ +LN+C DDIE + K EA L+ KGK D L +A+P + ++ +K K + NLL +L I NP++ +
Sbjct: 73 QNVIEVYPLASIGTV---QHISDDTDLNSVLLFSTL--QTDDKYAATHLFQSD--RVPVASGYAFYLTIAAFSVHSQSNIKKPSRV-PRGSSQGDGEQEDSNSLEA---------LEARTNRDVQILNHCIDDIENLVWRTKRSAEAWKKLQKKKGKVKADSQLALEARPPPEADFVDAFQKFKHAFNLLARLRQHIHNPNASE 259
BLAST of Epidermal growth factor receptor kinase substrate 8 vs. Ensembl Medaka
Match: eps8l1b (epidermal growth factor receptor kinase substrate 8-like protein 1 [Source:NCBI gene;Acc:101168497]) HSP 1 Score: 155.221 bits (391), Expect = 8.936e-40 Identity = 135/503 (26.84%), Postives = 232/503 (46.12%), Query Frame = 2
Query: 647 RTERNLLLLNYCFDDIEFFLQHLKDQEEAQAILKN--------TKGKNLNDRLLEGKAKPSTQNAYLTCIEKIKFSLNLLCKLDGKIKNPDSRQXXXXXXXXXXXXGQAYSIYHNGKLSKVKEPLLTEDTVKLLHQCLSKHYHKQWTSWGDNWCKAREKWAGYKEKYYPEFFNGYQIDLEELMKDGII--SPIADIPRRAVSNAEISHAIFYNQALPMIAQTDILENTVLSSRE--EDFCRSVTLRNGKLYRVIATFAASKDEELSMSEGEIIEVIESKPDKNWWLCGNMHGQKGYSPNTLLEPFCYIDRSINNFIKSSPESPDYLNVRNI----PTVPVSPKRISQIMKDPNS----------ADKVAEANIINEELKKKINTNSNFGGWNSRASFARPGPVVSKKHGQLSINQDSTSEDVQKWLEYKKFSPSDIEKLKIFNGQTLFLLSRDEMVRIVSSEVANRLDSLVKVQKSLSGFGTLSRR--ELDEILTKRKEKVEI 2071
R ER + +LN+CFDDIE F+ L+ +A +L +K ++ D +L KA+P ++ +K K+ +LL +L I +P S +L+ + + L + + G + V P +T + LL + L++ + WTS G NW R K G Y P F +G++ E DG + P+ E H ++AL + + ++ LS R ED ++ +LY F A + ELS+ +GE +EVIES K WW C N Q G+ P +LEP +I+ N + P + + P+ P P+ S + P++ AD+ + ++N+EL +++ N +A+ +P + + ++ S E+V +WL K FS ++ L + G LF L++DE+ ++ E R+ S + VQK+L +RR EL+ ++ K+K KV++
Sbjct: 45 RAEREVGILNHCFDDIESFMGKLQQTADAALVLSQRKTKKKKKSKKQSAEDEMLAAKAQPPQAEEFVEIFQKFKYCFSLLARLKSTIVSPSSEELVHHVFKPLDMMVKTTGGPAMG--AAVSSPAMTNSAISLLQETLNEEEKQLWTSLGPNWTHPRSKLRGPVAPYTPVFLDGWKP--EAARADGQVWEDPV-----------ESQHK---HEALLVKQEQQPPQSKRLSDRNNYEDMV-ALPPDAERLYSCSYDFIARNNSELSVQQGETLEVIES--SKRWWKCRNRFNQIGFVPFNILEPVTHIEHPTNGPPPAPTPPPANAPPKTLLGVQPSPPALPRTASSSPQRPHTLPSYNQAVQVADETDKVMLVNDELLQRLT--------NGKANLNKPLVIPRSSETSVPLDYHSPPEEVTEWLRGKGFSEPTVKCLGVLTGAQLFSLTKDELREVIPEE-GTRVYSQLTVQKALL---EDARRATELEAVMEKQKMKVDL 514
BLAST of Epidermal growth factor receptor kinase substrate 8 vs. Ensembl Medaka
Match: eps8l1b (epidermal growth factor receptor kinase substrate 8-like protein 1 [Source:NCBI gene;Acc:101168497]) HSP 1 Score: 154.836 bits (390), Expect = 5.725e-39 Identity = 135/503 (26.84%), Postives = 232/503 (46.12%), Query Frame = 2
Query: 647 RTERNLLLLNYCFDDIEFFLQHLKDQEEAQAILKN--------TKGKNLNDRLLEGKAKPSTQNAYLTCIEKIKFSLNLLCKLDGKIKNPDSRQXXXXXXXXXXXXGQAYSIYHNGKLSKVKEPLLTEDTVKLLHQCLSKHYHKQWTSWGDNWCKAREKWAGYKEKYYPEFFNGYQIDLEELMKDGII--SPIADIPRRAVSNAEISHAIFYNQALPMIAQTDILENTVLSSRE--EDFCRSVTLRNGKLYRVIATFAASKDEELSMSEGEIIEVIESKPDKNWWLCGNMHGQKGYSPNTLLEPFCYIDRSINNFIKSSPESPDYLNVRNI----PTVPVSPKRISQIMKDPNS----------ADKVAEANIINEELKKKINTNSNFGGWNSRASFARPGPVVSKKHGQLSINQDSTSEDVQKWLEYKKFSPSDIEKLKIFNGQTLFLLSRDEMVRIVSSEVANRLDSLVKVQKSLSGFGTLSRR--ELDEILTKRKEKVEI 2071
R ER + +LN+CFDDIE F+ L+ +A +L +K ++ D +L KA+P ++ +K K+ +LL +L I +P S +L+ + + L + + G + V P +T + LL + L++ + WTS G NW R K G Y P F +G++ E DG + P+ E H ++AL + + ++ LS R ED ++ +LY F A + ELS+ +GE +EVIES K WW C N Q G+ P +LEP +I+ N + P + + P+ P P+ S + P++ AD+ + ++N+EL +++ N +A+ +P + + ++ S E+V +WL K FS ++ L + G LF L++DE+ ++ E R+ S + VQK+L +RR EL+ ++ K+K KV++
Sbjct: 191 RAEREVGILNHCFDDIESFMGKLQQTADAALVLSQRKTKKKKKSKKQSAEDEMLAAKAQPPQAEEFVEIFQKFKYCFSLLARLKSTIVSPSSEELVHHVFKPLDMMVKTTGGPAMG--AAVSSPAMTNSAISLLQETLNEEEKQLWTSLGPNWTHPRSKLRGPVAPYTPVFLDGWKP--EAARADGQVWEDPV-----------ESQHK---HEALLVKQEQQPPQSKRLSDRNNYEDMV-ALPPDAERLYSCSYDFIARNNSELSVQQGETLEVIES--SKRWWKCRNRFNQIGFVPFNILEPVTHIEHPTNGPPPAPTPPPANAPPKTLLGVQPSPPALPRTASSSPQRPHTLPSYNQAVQVADETDKVMLVNDELLQRLT--------NGKANLNKPLVIPRSSETSVPLDYHSPPEEVTEWLRGKGFSEPTVKCLGVLTGAQLFSLTKDELREVIPEE-GTRVYSQLTVQKALL---EDARRATELEAVMEKQKMKVDL 660
BLAST of Epidermal growth factor receptor kinase substrate 8 vs. Ensembl Medaka
Match: EPS8L2 (EPS8 like 2 [Source:NCBI gene;Acc:101169604]) HSP 1 Score: 120.553 bits (301), Expect = 8.217e-28 Identity = 136/503 (27.04%), Postives = 219/503 (43.54%), Query Frame = 2
Query: 629 NDDISSRTERNLLLLNYCFDDIEFFLQHLKDQEEAQAILKN------TKGKNLNDRLLEGKAKPSTQNAYLTCIEKIKFSLNLLCKLDGKIKNPDSRQXXXXXXXXXXXXGQAYSIYHNGKLSK-VKEPLLTEDTVKLLHQCLSKHYHKQWTSWGDNWCKAREKWA--GYKEKYYPEFFNGYQIDLEELMKDGIISPIADIPRRAVSNAEISHAIFYNQALPMIAQTDILENTVLSSREEDFCRSVTLR-----------NGKLYRVIATFAASKDEELSMSEGEIIEVIESKPDKNWWLCGNMHGQKGYSPNTLLEPFCYIDRSINNFIKSSPESPDYLNVRNIPTVPVSPKRISQIMKDPNSADKVAEANIINEELKKKINTNSNFGGWNSRASFARPGPVVSKKHG---QLSINQDSTSEDVQKWLEYKKFSPSDIEKLKIFNGQTLFLLSRDEMVRIVSSEVANRLDSLVKVQKSLSGFGTLSRRELDEILTKRKEKVE 2068
++++ R E+++ +LN DDIE F+ L+ EA + LK K K + +L +AKP ++ ++ ++K+K +LNLL KL I+NP++ +L+ L L + Q + L++ + P L++DTV L L+ + GD W K R +W YYP+F NG++ P A++ A E F Q P + D +++ ED+ + + N K ++ F A ELS+ + EI+EV+E DK WW N GQ GY P +L+ D P+ P N ++ T P + DK + +N EL KKI AS +P ++ K Q+ + DS V WL K FS ++ L I G LF L++DE+ + V + R+ V VQK + S EL EI+ +R+E+++
Sbjct: 206 HENLPQRIEKDVQILNCALDDIEIFVARLQKAAEAFSQLKQRNKSKKNKKKGPAEGMLTLRAKPPSEAEFIDSLQKLKLALNLLTKLRKHIQNPNASELVHFLFGPLELVLQTCG---SPDLARSIISPHLSKDTVDFLRGHLTPKETTIFELLGDGWTKPRAEWPRDQCAPPYYPKFRNGWE-------------PPAELFLTASWETEGPSGQFAGQHGPPFS-PDYRQHS-----SEDYYGTHSSNSSNGSYSEKPNNRKFAKIRYNFVARNANELSVLQDEILEVLED--DKQWWKLRNRSGQAGYVPFNVLDVVKIED----------PDVP--YNQKSFMTSPSGSASREDSFNKGITKDKAMDE--VNNELLKKIT-----------ASKTQPPKLIHVKRTPSTQVPLTSDSNPGQVTAWLNAKGFSKPTVDCLGILTGAQLFSLNKDEL-KAVCGDEGGRVYFQVTVQKEQVEKSSGS-SELQEIMKRRQERID 657
BLAST of Epidermal growth factor receptor kinase substrate 8 vs. Ensembl Medaka
Match: EPS8L2 (EPS8 like 2 [Source:NCBI gene;Acc:101169604]) HSP 1 Score: 120.553 bits (301), Expect = 9.372e-28 Identity = 136/503 (27.04%), Postives = 220/503 (43.74%), Query Frame = 2
Query: 629 NDDISSRTERNLLLLNYCFDDIEFFLQHLKDQEEAQAILKN------TKGKNLNDRLLEGKAKPSTQNAYLTCIEKIKFSLNLLCKLDGKIKNPDSRQXXXXXXXXXXXXGQAYSIYHNGKLSK-VKEPLLTEDTVKLLHQCLSKHYHKQWTSWGDNWCKAREKWAGYK--EKYYPEFFNGYQIDLEELMKDGIISPIADIPRRAVSNAEISHAIFYNQALPMIAQTDILENTVLSSREEDFCRSVTLR-----------NGKLYRVIATFAASKDEELSMSEGEIIEVIESKPDKNWWLCGNMHGQKGYSPNTLLEPFCYIDRSINNFIKSSPESPDYLNVRNIPTVPVSPKRISQIMKDPNSADKVAEANIINEELKKKINTNSNFGGWNSRASFARPGPVVSKKHG---QLSINQDSTSEDVQKWLEYKKFSPSDIEKLKIFNGQTLFLLSRDEMVRIVSSEVANRLDSLVKVQKSLSGFGTLSRRELDEILTKRKEKVE 2068
++++ R E+++ +LN DDIE F+ L+ EA + LK K K + +L +AKP ++ ++ ++K+K +LNLL KL I+NP++ +L+ L L + Q + L++ + P L++DTV L L+ + GD W K R +W + YYP+F NG++ P A++ A E F Q P + D +++ ED+ + + N K ++ F A ELS+ + EI+EV+E DK WW N GQ GY P +L+ D P+ P N ++ T P + DK + +N EL KKI AS +P ++ K Q+ + DS V WL K FS ++ L I G LF L++DE+ + V + R+ V VQK + S EL EI+ +R+E+++
Sbjct: 233 HENLPQRIEKDVQILNCALDDIEIFVARLQKAAEAFSQLKQRNKSKKNKKKGPAEGMLTLRAKPPSEAEFIDSLQKLKLALNLLTKLRKHIQNPNASELVHFLFGPLELVLQTCG---SPDLARSIISPHLSKDTVDFLRGHLTPKETTIFELLGDGWTKPRAEWPRDQCAPPYYPKFRNGWE-------------PPAELFLTASWETEGPSGQFAGQHGPPFS-PDYRQHS-----SEDYYGTHSSNSSNGSYSEKPNNRKFAKIRYNFVARNANELSVLQDEILEVLED--DKQWWKLRNRSGQAGYVPFNVLDVVKIED----------PDVP--YNQKSFMTSPSGSASREDSFNKGITKDKAMDE--VNNELLKKIT-----------ASKTQPPKLIHVKRTPSTQVPLTSDSNPGQVTAWLNAKGFSKPTVDCLGILTGAQLFSLNKDEL-KAVCGDEGGRVYFQVTVQKEQVEKSSGS-SELQEIMKRRQERID 684
BLAST of Epidermal growth factor receptor kinase substrate 8 vs. Ensembl Medaka
Match: EPS8L2 (EPS8 like 2 [Source:NCBI gene;Acc:101169604]) HSP 1 Score: 120.168 bits (300), Expect = 1.055e-27 Identity = 136/503 (27.04%), Postives = 219/503 (43.54%), Query Frame = 2
Query: 629 NDDISSRTERNLLLLNYCFDDIEFFLQHLKDQEEAQAILKN------TKGKNLNDRLLEGKAKPSTQNAYLTCIEKIKFSLNLLCKLDGKIKNPDSRQXXXXXXXXXXXXGQAYSIYHNGKLSK-VKEPLLTEDTVKLLHQCLSKHYHKQWTSWGDNWCKAREKWA--GYKEKYYPEFFNGYQIDLEELMKDGIISPIADIPRRAVSNAEISHAIFYNQALPMIAQTDILENTVLSSREEDFCRSVTLR-----------NGKLYRVIATFAASKDEELSMSEGEIIEVIESKPDKNWWLCGNMHGQKGYSPNTLLEPFCYIDRSINNFIKSSPESPDYLNVRNIPTVPVSPKRISQIMKDPNSADKVAEANIINEELKKKINTNSNFGGWNSRASFARPGPVVSKKHG---QLSINQDSTSEDVQKWLEYKKFSPSDIEKLKIFNGQTLFLLSRDEMVRIVSSEVANRLDSLVKVQKSLSGFGTLSRRELDEILTKRKEKVE 2068
++++ R E+++ +LN DDIE F+ L+ EA + LK K K + +L +AKP ++ ++ ++K+K +LNLL KL I+NP++ +L+ L L + Q + L++ + P L++DTV L L+ + GD W K R +W YYP+F NG++ P A++ A E F Q P + D +++ ED+ + + N K ++ F A ELS+ + EI+EV+E DK WW N GQ GY P +L+ D P+ P N ++ T P + DK + +N EL KKI AS +P ++ K Q+ + DS V WL K FS ++ L I G LF L++DE+ + V + R+ V VQK + S EL EI+ +R+E+++
Sbjct: 234 HENLPQRIEKDVQILNCALDDIEIFVARLQKAAEAFSQLKQRNKSKKNKKKGPAEGMLTLRAKPPSEAEFIDSLQKLKLALNLLTKLRKHIQNPNASELVHFLFGPLELVLQTCG---SPDLARSIISPHLSKDTVDFLRGHLTPKETTIFELLGDGWTKPRAEWPRDQCAPPYYPKFRNGWE-------------PPAELFLTASWETEGPSGQFAGQHGPPFS-PDYRQHS-----SEDYYGTHSSNSSNGSYSEKPNNRKFAKIRYNFVARNANELSVLQDEILEVLED--DKQWWKLRNRSGQAGYVPFNVLDVVKIED----------PDVP--YNQKSFMTSPSGSASREDSFNKGITKDKAMDE--VNNELLKKIT-----------ASKTQPPKLIHVKRTPSTQVPLTSDSNPGQVTAWLNAKGFSKPTVDCLGILTGAQLFSLNKDEL-KAVCGDEGGRVYFQVTVQKEQVEKSSGS-SELQEIMKRRQERID 685
BLAST of Epidermal growth factor receptor kinase substrate 8 vs. Planmine SMEST
Match: SMESG000070650.1 (SMESG000070650.1) HSP 1 Score: 1357.81 bits (3513), Expect = 0.000e+0 Identity = 670/671 (99.85%), Postives = 671/671 (100.00%), Query Frame = 2
Query: 71 MNGTYLKMDSSKSKTKWVARHFGSFMQTGTGKDSTNKALNELCSQIDDGRFRELQCNIEIDRERQVLVIRRWLDQVILEEFKLALITNVASHQQVPDNNYLSNILTFNTQIKTSSNVLTETHIFQLEDSNLHMVNYLASDIRSAIESATNLNPKNTPIKVLPSNNKRNSYSNEKMNKVKEYDSKPRNDDISSRTERNLLLLNYCFDDIEFFLQHLKDQEEAQAILKNTKGKNLNDRLLEGKAKPSTQNAYLTCIEKIKFSLNLLCKLDGKIKNPDSRQXXXXXXXXXXXXGQAYSIYHNGKLSKVKEPLLTEDTVKLLHQCLSKHYHKQWTSWGDNWCKAREKWAGYKEKYYPEFFNGYQIDLEELMKDGIISPIADIPRRAVSNAEISHAIFYNQALPMIAQTDILENTVLSSREEDFCRSVTLRNGKLYRVIATFAASKDEELSMSEGEIIEVIESKPDKNWWLCGNMHGQKGYSPNTLLEPFCYIDRSINNFIKSSPESPDYLNVRNIPTVPVSPKRISQIMKDPNSADKVAEANIINEELKKKINTNSNFGGWNSRASFARPGPVVSKKHGQLSINQDSTSEDVQKWLEYKKFSPSDIEKLKIFNGQTLFLLSRDEMVRIVSSEVANRLDSLVKVQKSLSGFGTLSRRELDEILTKRKEKVEITETF 2083
MNGTYLKMDSSKSKTKWVARHFGSFMQTGTGKDSTNKALNELCSQIDDGRFRELQCNIEIDRERQVLVIRRWLDQVILEEFKLALITNVASHQQVPDNNYLSNILTFNTQIKTSSNVLTETHIFQLEDSNLHMVNYLASDIRSAIESATNLNPKNTPIKVLPSNNKRNSYSNEKMNKVKEY+SKPRNDDISSRTERNLLLLNYCFDDIEFFLQHLKDQEEAQAILKNTKGKNLNDRLLEGKAKPSTQNAYLTCIEKIKFSLNLLCKLDGKIKNPDSRQLILLLIENLLKIGQAYSIYHNGKLSKVKEPLLTEDTVKLLHQCLSKHYHKQWTSWGDNWCKAREKWAGYKEKYYPEFFNGYQIDLEELMKDGIISPIADIPRRAVSNAEISHAIFYNQALPMIAQTDILENTVLSSREEDFCRSVTLRNGKLYRVIATFAASKDEELSMSEGEIIEVIESKPDKNWWLCGNMHGQKGYSPNTLLEPFCYIDRSINNFIKSSPESPDYLNVRNIPTVPVSPKRISQIMKDPNSADKVAEANIINEELKKKINTNSNFGGWNSRASFARPGPVVSKKHGQLSINQDSTSEDVQKWLEYKKFSPSDIEKLKIFNGQTLFLLSRDEMVRIVSSEVANRLDSLVKVQKSLSGFGTLSRRELDEILTKRKEKVEITETF
Sbjct: 1 MNGTYLKMDSSKSKTKWVARHFGSFMQTGTGKDSTNKALNELCSQIDDGRFRELQCNIEIDRERQVLVIRRWLDQVILEEFKLALITNVASHQQVPDNNYLSNILTFNTQIKTSSNVLTETHIFQLEDSNLHMVNYLASDIRSAIESATNLNPKNTPIKVLPSNNKRNSYSNEKMNKVKEYESKPRNDDISSRTERNLLLLNYCFDDIEFFLQHLKDQEEAQAILKNTKGKNLNDRLLEGKAKPSTQNAYLTCIEKIKFSLNLLCKLDGKIKNPDSRQLILLLIENLLKIGQAYSIYHNGKLSKVKEPLLTEDTVKLLHQCLSKHYHKQWTSWGDNWCKAREKWAGYKEKYYPEFFNGYQIDLEELMKDGIISPIADIPRRAVSNAEISHAIFYNQALPMIAQTDILENTVLSSREEDFCRSVTLRNGKLYRVIATFAASKDEELSMSEGEIIEVIESKPDKNWWLCGNMHGQKGYSPNTLLEPFCYIDRSINNFIKSSPESPDYLNVRNIPTVPVSPKRISQIMKDPNSADKVAEANIINEELKKKINTNSNFGGWNSRASFARPGPVVSKKHGQLSINQDSTSEDVQKWLEYKKFSPSDIEKLKIFNGQTLFLLSRDEMVRIVSSEVANRLDSLVKVQKSLSGFGTLSRRELDEILTKRKEKVEITETF 671
BLAST of Epidermal growth factor receptor kinase substrate 8 vs. Planmine SMEST
Match: SMESG000070650.1 (SMESG000070650.1) HSP 1 Score: 1342.41 bits (3473), Expect = 0.000e+0 Identity = 663/664 (99.85%), Postives = 664/664 (100.00%), Query Frame = 2
Query: 92 MDSSKSKTKWVARHFGSFMQTGTGKDSTNKALNELCSQIDDGRFRELQCNIEIDRERQVLVIRRWLDQVILEEFKLALITNVASHQQVPDNNYLSNILTFNTQIKTSSNVLTETHIFQLEDSNLHMVNYLASDIRSAIESATNLNPKNTPIKVLPSNNKRNSYSNEKMNKVKEYDSKPRNDDISSRTERNLLLLNYCFDDIEFFLQHLKDQEEAQAILKNTKGKNLNDRLLEGKAKPSTQNAYLTCIEKIKFSLNLLCKLDGKIKNPDSRQXXXXXXXXXXXXGQAYSIYHNGKLSKVKEPLLTEDTVKLLHQCLSKHYHKQWTSWGDNWCKAREKWAGYKEKYYPEFFNGYQIDLEELMKDGIISPIADIPRRAVSNAEISHAIFYNQALPMIAQTDILENTVLSSREEDFCRSVTLRNGKLYRVIATFAASKDEELSMSEGEIIEVIESKPDKNWWLCGNMHGQKGYSPNTLLEPFCYIDRSINNFIKSSPESPDYLNVRNIPTVPVSPKRISQIMKDPNSADKVAEANIINEELKKKINTNSNFGGWNSRASFARPGPVVSKKHGQLSINQDSTSEDVQKWLEYKKFSPSDIEKLKIFNGQTLFLLSRDEMVRIVSSEVANRLDSLVKVQKSLSGFGTLSRRELDEILTKRKEKVEITETF 2083
MDSSKSKTKWVARHFGSFMQTGTGKDSTNKALNELCSQIDDGRFRELQCNIEIDRERQVLVIRRWLDQVILEEFKLALITNVASHQQVPDNNYLSNILTFNTQIKTSSNVLTETHIFQLEDSNLHMVNYLASDIRSAIESATNLNPKNTPIKVLPSNNKRNSYSNEKMNKVKEY+SKPRNDDISSRTERNLLLLNYCFDDIEFFLQHLKDQEEAQAILKNTKGKNLNDRLLEGKAKPSTQNAYLTCIEKIKFSLNLLCKLDGKIKNPDSRQLILLLIENLLKIGQAYSIYHNGKLSKVKEPLLTEDTVKLLHQCLSKHYHKQWTSWGDNWCKAREKWAGYKEKYYPEFFNGYQIDLEELMKDGIISPIADIPRRAVSNAEISHAIFYNQALPMIAQTDILENTVLSSREEDFCRSVTLRNGKLYRVIATFAASKDEELSMSEGEIIEVIESKPDKNWWLCGNMHGQKGYSPNTLLEPFCYIDRSINNFIKSSPESPDYLNVRNIPTVPVSPKRISQIMKDPNSADKVAEANIINEELKKKINTNSNFGGWNSRASFARPGPVVSKKHGQLSINQDSTSEDVQKWLEYKKFSPSDIEKLKIFNGQTLFLLSRDEMVRIVSSEVANRLDSLVKVQKSLSGFGTLSRRELDEILTKRKEKVEITETF
Sbjct: 1 MDSSKSKTKWVARHFGSFMQTGTGKDSTNKALNELCSQIDDGRFRELQCNIEIDRERQVLVIRRWLDQVILEEFKLALITNVASHQQVPDNNYLSNILTFNTQIKTSSNVLTETHIFQLEDSNLHMVNYLASDIRSAIESATNLNPKNTPIKVLPSNNKRNSYSNEKMNKVKEYESKPRNDDISSRTERNLLLLNYCFDDIEFFLQHLKDQEEAQAILKNTKGKNLNDRLLEGKAKPSTQNAYLTCIEKIKFSLNLLCKLDGKIKNPDSRQLILLLIENLLKIGQAYSIYHNGKLSKVKEPLLTEDTVKLLHQCLSKHYHKQWTSWGDNWCKAREKWAGYKEKYYPEFFNGYQIDLEELMKDGIISPIADIPRRAVSNAEISHAIFYNQALPMIAQTDILENTVLSSREEDFCRSVTLRNGKLYRVIATFAASKDEELSMSEGEIIEVIESKPDKNWWLCGNMHGQKGYSPNTLLEPFCYIDRSINNFIKSSPESPDYLNVRNIPTVPVSPKRISQIMKDPNSADKVAEANIINEELKKKINTNSNFGGWNSRASFARPGPVVSKKHGQLSINQDSTSEDVQKWLEYKKFSPSDIEKLKIFNGQTLFLLSRDEMVRIVSSEVANRLDSLVKVQKSLSGFGTLSRRELDEILTKRKEKVEITETF 664 The following BLAST results are available for this feature:
BLAST of Epidermal growth factor receptor kinase substrate 8 vs. Ensembl Human
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Human e!99) Total hits: 5
BLAST of Epidermal growth factor receptor kinase substrate 8 vs. Ensembl Celegans
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99) Total hits: 5
BLAST of Epidermal growth factor receptor kinase substrate 8 vs. Ensembl Fly
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99) Total hits: 5
BLAST of Epidermal growth factor receptor kinase substrate 8 vs. Ensembl Zebrafish
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99) Total hits: 5
BLAST of Epidermal growth factor receptor kinase substrate 8 vs. Ensembl Xenopus
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99) Total hits: 5
BLAST of Epidermal growth factor receptor kinase substrate 8 vs. Ensembl Mouse
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99) Total hits: 5
BLAST of Epidermal growth factor receptor kinase substrate 8 vs. UniProt/SwissProt
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt) Total hits: 5
BLAST of Epidermal growth factor receptor kinase substrate 8 vs. TrEMBL
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL) Total hits: 5
BLAST of Epidermal growth factor receptor kinase substrate 8 vs. Ensembl Cavefish
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99) Total hits: 5
BLAST of Epidermal growth factor receptor kinase substrate 8 vs. Ensembl Sea Lamprey
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99) Total hits: 2
BLAST of Epidermal growth factor receptor kinase substrate 8 vs. Ensembl Yeast
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46) Total hits: 0
BLAST of Epidermal growth factor receptor kinase substrate 8 vs. Ensembl Nematostella
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46) Total hits: 1
BLAST of Epidermal growth factor receptor kinase substrate 8 vs. Ensembl Medaka
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99) Total hits: 5
BLAST of Epidermal growth factor receptor kinase substrate 8 vs. Planmine SMEST
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST) Total hits: 2
Analyses
This transcript is derived from or has results from the following analyses Sequences
The following sequences are available for this feature:
transcript sequence >SMED30011084 ID=SMED30011084|Name=Epidermal growth factor receptor kinase substrate 8|organism=Schmidtea mediterranea sexual|type=transcript|length=2345bpback to top protein sequence of SMED30011084-orf-1 >SMED30011084-orf-1 ID=SMED30011084-orf-1|Name=SMED30011084-orf-1|organism=Schmidtea mediterranea sexual|type=polypeptide|length=672bp MNGTYLKMDSSKSKTKWVARHFGSFMQTGTGKDSTNKALNELCSQIDDGRback to top Annotated Terms
The following terms have been associated with this transcript:
InterPro
Analysis Name: Schmidtea mediteranean smed_20140614 Interproscan
Date Performed: 2020-05-01
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