SMED30010892
Overview
Neoblast Clusters
Zeng et. al., 2018▻ Overview▻ Neoblast Population▻ Sub-lethal Irradiated Surviving X1 and X2 Cell Population
Overview
Single cell RNA-seq of pluripotent neoblasts and its early progeniesWe isolated X1 neoblasts cells enriched in high piwi-1 expression (Neoblast Population), and profiled ∼7,614 individual cells via scRNA-seq. Unsupervised analyses uncovered 12 distinct classes from 7,088 high-quality cells. We designated these classes Nb1 to Nb12 and ordered them based on high (Nb1) to low (Nb12) piwi-1 expression levels. We further defined groups of genes that best classified the cells parsed into 12 distinct cell clusters to generate a scaled expression heat map of discriminative gene sets for each cluster. Expression of each cluster’s gene signatures was validated using multiplex fluorescence in situ hybridization (FISH) co-stained with piwi-1 and largely confirmed the cell clusters revealed by scRNA-seq.We also tested sub-lethal irradiation exposure. To profile rare pluripotent stem cells (PSCs) and avoid interference from immediate progenitor cells, we determined a time point after sub-lethal irradiation (7 DPI) with minimal piwi-1+ cells, followed by isolation and single-cell RNA-seq of 1,200 individual cells derived from X1 (Piwi-1 high) and X2 (Piwi-1 low) cell populations (Sub-lethal Irradiated Surviving X1 and X2 Cell Population)Explore this single cell expression dataset with our NB Cluster Shiny App
Neoblast Population
Sub-lethal Irradiated Surviving X1 and X2 Cell Population
Embryonic Expression
Davies et. al., 2017
Hover the mouse over a column in the graph to view average RPKM values per sample. Embryonic Stages: Y: yolk. S2-S8: Stages 2-8. C4: asexual adult. SX: virgin, sexually mature adult. back to top Anatomical Expression
PAGE et. al., 2020SMED30010892 has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGEPAGE Curations: 7
Alignments
SMED30010892 aligns in the following genomic locations:
Homology
BLAST of SMED30010892 vs. TrEMBL
Match: G4V7Z5 (Uncharacterized protein OS=Schistosoma mansoni OX=6183 GN=Smp_035290 PE=4 SV=1) HSP 1 Score: 95.5153 bits (236), Expect = 5.263e-19 Identity = 52/139 (37.41%), Postives = 78/139 (56.12%), Query Frame = 3 Query: 669 LMPEAEKKIRVWLNTATSEEKGTSINFFKRLLE--NENLSTDDKYFIQHILEIIKNEEDYWLTRK-SHPQFSTNNGEAKLKFLNLQTPESRRQRWMYTSWNHMPPYKEEKV--FEFPGSHYCIPNKSLPNTYNIHPDMG 1070 + P+AE+ +R WL A+ E+ T++ +L NE D F Q +++ +KN W K SHP FS ++G K+L+L + + RR WMY SW+H+PPYK +++PGSHY + P Y IHPD+G Sbjct: 104 MSPKAERYVRRWLTDASPLERTTALELIDKLYREANEQDQLTDTQF-QDVMKRVKNIN--WDQNKTSHPVFSRSDGSTHFKYLDLLSQQERRNHWMYCSWHHLPPYKISSTAKYDYPGSHYLHLLERQPKEYVIHPDLG 239
BLAST of SMED30010892 vs. TrEMBL
Match: A0A183L8M5 (Uncharacterized protein OS=Schistosoma margrebowiei OX=48269 GN=SMRZ_LOCUS150 PE=4 SV=1) HSP 1 Score: 94.7449 bits (234), Expect = 8.673e-19 Identity = 51/139 (36.69%), Postives = 78/139 (56.12%), Query Frame = 3 Query: 669 LMPEAEKKIRVWLNTATSEEKGTSINFFKRLLE--NENLSTDDKYFIQHILEIIKN-EEDYWLTRKSHPQFSTNNGEAKLKFLNLQTPESRRQRWMYTSWNHMPPYKEEKV--FEFPGSHYCIPNKSLPNTYNIHPDMG 1070 + P+AE+ +R WL A+ E+ T++ +L NE D F Q +++ +KN D + HP FS ++G LK+L+L T + RR WMY SW+H+PPY+ +++PGSHY + P Y IHPD+G Sbjct: 90 MSPKAERYVRRWLTDASPLERTTALELIDKLYSETNEQDQLTDTQF-QIVMKRVKNINRDQ--NKTPHPVFSRSDGSTHLKYLDLLTKQERRDHWMYCSWHHLPPYRISSTAKYDYPGSHYLHLLERQPKEYVIHPDLG 225
BLAST of SMED30010892 vs. TrEMBL
Match: A0A095C5F7 (Uncharacterized protein OS=Schistosoma haematobium OX=6185 GN=MS3_05449 PE=4 SV=1) HSP 1 Score: 93.2041 bits (230), Expect = 3.227e-18 Identity = 50/142 (35.21%), Postives = 79/142 (55.63%), Query Frame = 3 Query: 669 LMPEAEKKIRVWLNTATSEEKGTSINFFKRLLE--NENLSTDDKYFIQHILEIIKNEEDYWLTRKS----HPQFSTNNGEAKLKFLNLQTPESRRQRWMYTSWNHMPPYKEEKV--FEFPGSHYCIPNKSLPNTYNIHPDMG 1070 + P+AE+ +R WL A+ E+ T++ +L NE D F Q +++ +KN ++R HP FS ++G LK+L+L T + RR WMY SW+H+PPY+ +++PGS+Y + P Y IHPD+G Sbjct: 91 MSPKAERYVRRWLTDASPLERTTALELIDKLYRETNEQDQLTDTQF-QIVMKRVKN-----ISRDQNKTPHPVFSRSDGSTHLKYLDLLTKQERRDHWMYCSWHHLPPYRISSTAKYDYPGSYYLHLLERQPKEYVIHPDLG 226
BLAST of SMED30010892 vs. TrEMBL
Match: A0A430QKX7 (Uncharacterized protein OS=Schistosoma bovis OX=6184 GN=DC041_0000952 PE=4 SV=1) HSP 1 Score: 91.6633 bits (226), Expect = 1.235e-17 Identity = 67/231 (29.00%), Postives = 113/231 (48.92%), Query Frame = 3 Query: 453 KPKENKRKSSTISTSKPAIVNKTKERIEKPDFIKESSVS--------QLLDNANLTERRIILKSFFLSNPQILKFSLRQALMPEAEKKIRVWLNTATSEEKGTSINFFKRLLE--NENLSTDDKYFIQHILEIIKNEEDY------------WLTRKS-HPQFSTNNGEAKLKFLNLQTPESRRQRWMYTSWNHMPPYKEEKV--FEFPGSHYCIPNKSLPNTYNIHPDMG 1070 K +N + +ST+ + ++V K K ++ + + +SS++ + NLT++ S SN K + + P+AE+ +R WL A+ E+ T++ +L NE D F Q +++ +K + W K+ HP FS ++G LK+L+L T + RR WMY SW+H+PPY+ +++PGSHY + P Y IHPD+G Sbjct: 15 KADDNLQANSTVVVAD-SMVQKKKNLVKCTETLDDSSMTLEEHTIKKKSDSKENLTQKNTTSAS---SNDFASKDPISTIMSPKAERYVRRWLTDASPLERTTALELIDKLYRETNEQDQLTDTQF-QIVMKRVKKDNAILRINLNIFCSINWDQNKTPHPVFSRSDGSTHLKYLDLLTKQERRDHWMYCSWHHLPPYRISSTAKYDYPGSHYLHLLERQPKEYVIHPDLG 240
BLAST of SMED30010892 vs. TrEMBL
Match: A0A210QLW0 (Uncharacterized protein OS=Mizuhopecten yessoensis OX=6573 GN=KP79_PYT04536 PE=4 SV=1) HSP 1 Score: 91.2781 bits (225), Expect = 1.840e-16 Identity = 56/221 (25.34%), Postives = 110/221 (49.77%), Query Frame = 3 Query: 465 NKRKSSTISTSKPAIVNKTKERIEKPDFIKES-----------SVSQLLDNANLTERRIILKSFFLSN-PQILKFSLRQALMPEAEKKIRVWLNTATSEEKGTSINFFKRLLENENLS---TDDKYFIQHILEIIKNEEDYWLTRKSHPQFSTNNGE----AKLKFLNLQTPESRRQRWMYTSWNHMPPYKEEKVFEFPGSHYCIPNKSLPNTYNIHPDMG 1070 NK + + T+ P + + E +KE +LL A +RR+I K +++ Q ++ SL++ +MP+A +++ WL +A +E+ ++ FF L + + T+ K +Q +++ ++ + ++ Q NN + KL+ + L +P++R++RWM+T+W+H+P Y ++ SHY P +P + IHPD G Sbjct: 195 NKAAGTPVPTASPEVPKQQAPSEEDVKVVKEDFKTSLQPHVVDKADELLKLAPKADRRVIEKILKMADRKQQMENSLKKTMMPDAREEVEKWLTSANDDERQVALKFFNSLAGTKLMGITKTEQKKRLQQVIDTLEGASE----KRVGGQRPRNNNDRTKAGKLQHMRLLSPQTRKERWMHTTWHHLPEYNDKGAGNM-SSHYIRPQAPIPRHFVIHPDWG 410
BLAST of SMED30010892 vs. Planmine SMEST
Match: SMESG000021730.1 (SMESG000021730.1) HSP 1 Score: 656.366 bits (1692), Expect = 0.000e+0 Identity = 338/339 (99.71%), Postives = 338/339 (99.71%), Query Frame = 3 Query: 54 MLQHQDYYNNLIYGRNCCRIHSNNVSRSLKVINYDSRGIIQQNTDSLXXXXXXXXXXXXXXXXIFDFLRNRPNKLNEEGLQRSITDLNFISRKENKVMNSAIDQKAFRTWKIPESIISGKFPTIQPSNIEINHKPKENKRKSSTISTSKPAIVNKTKERIEKPDFIKESSVSQLLDNANLTERRIILKSFFLSNPQILKFSLRQALMPEAEKKIRVWLNTATSEEKGTSINFFKRLLENENLSTDDKYFIQHILEIIKNEEDYWLTRKSHPQFSTNNGEAKLKFLNLQTPESRRQRWMYTSWNHMPPYKEEKVFEFPGSHYCIPNKSLPNTYNIHPDMG 1070 MLQHQDYYNNLIYGRNCCRIHSNNVSRSLKVINYDSRGII QNTDSLDKNSYNDYYTTYKTDYIFDFLRNRPNKLNEEGLQRSITDLNFISRKENKVMNSAIDQKAFRTWKIPESIISGKFPTIQPSNIEINHKPKENKRKSSTISTSKPAIVNKTKERIEKPDFIKESSVSQLLDNANLTERRIILKSFFLSNPQILKFSLRQALMPEAEKKIRVWLNTATSEEKGTSINFFKRLLENENLSTDDKYFIQHILEIIKNEEDYWLTRKSHPQFSTNNGEAKLKFLNLQTPESRRQRWMYTSWNHMPPYKEEKVFEFPGSHYCIPNKSLPNTYNIHPDMG Sbjct: 1 MLQHQDYYNNLIYGRNCCRIHSNNVSRSLKVINYDSRGIIHQNTDSLDKNSYNDYYTTYKTDYIFDFLRNRPNKLNEEGLQRSITDLNFISRKENKVMNSAIDQKAFRTWKIPESIISGKFPTIQPSNIEINHKPKENKRKSSTISTSKPAIVNKTKERIEKPDFIKESSVSQLLDNANLTERRIILKSFFLSNPQILKFSLRQALMPEAEKKIRVWLNTATSEEKGTSINFFKRLLENENLSTDDKYFIQHILEIIKNEEDYWLTRKSHPQFSTNNGEAKLKFLNLQTPESRRQRWMYTSWNHMPPYKEEKVFEFPGSHYCIPNKSLPNTYNIHPDMG 339
BLAST of SMED30010892 vs. Planmine SMEST
Match: SMESG000021730.1 (SMESG000021730.1) HSP 1 Score: 496.508 bits (1277), Expect = 1.137e-178 Identity = 242/242 (100.00%), Postives = 242/242 (100.00%), Query Frame = 3 Query: 345 MNSAIDQKAFRTWKIPESIISGKFPTIQPSNIEINHKPKENKRKSSTISTSKPAIVNKTKERIEKPDFIKESSVSQLLDNANLTERRIILKSFFLSNPQILKFSLRQALMPEAEKKIRVWLNTATSEEKGTSINFFKRLLENENLSTDDKYFIQHILEIIKNEEDYWLTRKSHPQFSTNNGEAKLKFLNLQTPESRRQRWMYTSWNHMPPYKEEKVFEFPGSHYCIPNKSLPNTYNIHPDMG 1070 MNSAIDQKAFRTWKIPESIISGKFPTIQPSNIEINHKPKENKRKSSTISTSKPAIVNKTKERIEKPDFIKESSVSQLLDNANLTERRIILKSFFLSNPQILKFSLRQALMPEAEKKIRVWLNTATSEEKGTSINFFKRLLENENLSTDDKYFIQHILEIIKNEEDYWLTRKSHPQFSTNNGEAKLKFLNLQTPESRRQRWMYTSWNHMPPYKEEKVFEFPGSHYCIPNKSLPNTYNIHPDMG Sbjct: 1 MNSAIDQKAFRTWKIPESIISGKFPTIQPSNIEINHKPKENKRKSSTISTSKPAIVNKTKERIEKPDFIKESSVSQLLDNANLTERRIILKSFFLSNPQILKFSLRQALMPEAEKKIRVWLNTATSEEKGTSINFFKRLLENENLSTDDKYFIQHILEIIKNEEDYWLTRKSHPQFSTNNGEAKLKFLNLQTPESRRQRWMYTSWNHMPPYKEEKVFEFPGSHYCIPNKSLPNTYNIHPDMG 242 The following BLAST results are available for this feature:
BLAST of SMED30010892 vs. Ensembl Human
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Human e!99) Total hits: 0
BLAST of SMED30010892 vs. Ensembl Celegans
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99) Total hits: 0
BLAST of SMED30010892 vs. Ensembl Fly
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99) Total hits: 0
BLAST of SMED30010892 vs. Ensembl Zebrafish
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99) Total hits: 0
BLAST of SMED30010892 vs. Ensembl Xenopus
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99) Total hits: 0
BLAST of SMED30010892 vs. Ensembl Mouse
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99) Total hits: 0
BLAST of SMED30010892 vs. UniProt/SwissProt
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt) Total hits: 0
BLAST of SMED30010892 vs. TrEMBL
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL) Total hits: 5
BLAST of SMED30010892 vs. Ensembl Cavefish
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99) Total hits: 0
BLAST of SMED30010892 vs. Ensembl Sea Lamprey
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99) Total hits: 0
BLAST of SMED30010892 vs. Ensembl Yeast
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46) Total hits: 0
BLAST of SMED30010892 vs. Ensembl Nematostella
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46) Total hits: 0
BLAST of SMED30010892 vs. Ensembl Medaka
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99) Total hits: 0
BLAST of SMED30010892 vs. Planmine SMEST
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST) Total hits: 2
Analyses
This transcript is derived from or has results from the following analyses Sequences
The following sequences are available for this feature:
transcript sequence >SMED30010892 ID=SMED30010892|Name=SMED30010892|organism=Schmidtea mediterranea sexual|type=transcript|length=1151bpback to top protein sequence of SMED30010892-orf-1 >SMED30010892-orf-1 ID=SMED30010892-orf-1|Name=SMED30010892-orf-1|organism=Schmidtea mediterranea sexual|type=polypeptide|length=340bp MLQHQDYYNNLIYGRNCCRIHSNNVSRSLKVINYDSRGIIQQNTDSLDKNback to top Annotated Terms
The following terms have been associated with this transcript:
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