Zinc ribbon domain containing 2

Overview


Name	Zinc ribbon domain containing 2
Smed ID	SMED30010888
Length (bp)	597

Neoblast Clusters

▻ Sub-lethal Irradiated Surviving X1 and X2 Cell Population

Overview

Single cell RNA-seq of pluripotent neoblasts and its early progenies

We isolated X1 neoblasts cells enriched in high piwi-1 expression (Neoblast Population), and profiled ∼7,614 individual cells via scRNA-seq. Unsupervised analyses uncovered 12 distinct classes from 7,088 high-quality cells. We designated these classes Nb1 to Nb12 and ordered them based on high (Nb1) to low (Nb12) piwi-1 expression levels. We further defined groups of genes that best classified the cells parsed into 12 distinct cell clusters to generate a scaled expression heat map of discriminative gene sets for each cluster. Expression of each cluster’s gene signatures was validated using multiplex fluorescence in situ hybridization (FISH) co-stained with piwi-1 and largely confirmed the cell clusters revealed by scRNA-seq.

We also tested sub-lethal irradiation exposure. To profile rare pluripotent stem cells (PSCs) and avoid interference from immediate progenitor cells, we determined a time point after sub-lethal irradiation (7 DPI) with minimal piwi-1+ cells, followed by isolation and single-cell RNA-seq of 1,200 individual cells derived from X1 (Piwi-1 high) and X2 (Piwi-1 low) cell populations (Sub-lethal Irradiated Surviving X1 and X2 Cell Population)

Explore this single cell expression dataset with our NB Cluster Shiny App

Neoblast Population

t-SNE plot shows two-dimensional representation of global gene expression relationships among all neoblasts (n = 7,088 after filter). Cluster identity was assigned based on the top 10 marker genes of each cluster (Table S2), followed by inspection of RNA in situ hybridization patterns. Neoblast groups, Nb.

Expression of Zinc ribbon domain containing 2 (SMED30010888) t-SNE clustered cells

Violin plots show distribution of expression levels for Zinc ribbon domain containing 2 (SMED30010888) in cells (dots) of each of the 12 neoblast clusters.

Sub-lethal Irradiated Surviving X1 and X2 Cell Population

t-SNE plot of surviving X1 and X2 cells (n = 1,039 after QC filter) after sub-lethal irradiation. Colors indicate unbiased cell classification via graph-based clustering. SL, sub-lethal irradiated cell groups.

Expression of Zinc ribbon domain containing 2 (SMED30010888) in the t-SNE clustered sub-lethally irradiated X1 and X2 cells.

Violin plots show distribution of expression levels for Zinc ribbon domain containing 2 (SMED30010888) in cells (dots) of each of the 10 clusters of sub-leathally irradiated X1 and X2 cells.

Embryonic Expression

Davies et. al., 2017

Hover the mouse over a column in the graph to view average RPKM values per sample.
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Embryonic Stages: Y: yolk. S2-S8: Stages 2-8. C4: asexual adult. SX: virgin, sexually mature adult.
For further information about sample preparation and analysis for the single animal RNA-Seq experiment, please refer to the Materials and Methods

Anatomical Expression

PAGE et. al., 2020

SMED30010888

has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGE

PAGE Curations: 2

Expressed In	Reference Transcript	Gene Models	Published Transcript	Transcriptome	Publication	Specimen	Lifecycle	Evidence
X1 cell	SMED30010888	h1SMcG0021672	SmedASXL_005006	SmedAsxl_ww_GCZZ01	PMID:26114597 Zhu et al., 2015
gut	SMED30010888	h1SMcG0021672	dd_Smed_v4_2060_0_1	dd_Smed_v4	PMID:29674431 Fincher et al., 2018

Note: Hover over icons to view figure legend

Homology

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BLAST of Zinc ribbon domain containing 2 vs. Ensembl Human
Match: ZNRD2 (zinc ribbon domain containing 2 [Source:HGNC Symbol;Acc:HGNC:11328])

HSP 1 Score: 97.4413 bits (241), Expect = 7.804e-25
Identity = 47/93 (50.54%), Postives = 65/93 (69.89%), Query Frame = 3

Query:   51 AEFGDYS-NLVSEAEQKLRNGKRERLNRISSIMGQYLLKGYTMLDETCVSCDTILLRSRQGQYHCVGCLDVDNDTAKDDPAVNMQAAISHFQE 326
            AE  D+S    +EAE K+   +RER +RIS +MG YLL+GY ML ETC  C TILL+ +Q + +CV C ++D+D  KD+PA+N QAA+S  +E
Sbjct:    6 AEVDDFSWEPPTEAETKVLQARRERQDRISRLMGDYLLRGYRMLGETCADCGTILLQDKQRKIYCVACQELDSDVDKDNPALNAQAALSQARE 98

[Close]

BLAST of Zinc ribbon domain containing 2 vs. Ensembl Human
Match: ZNRD2 (zinc ribbon domain containing 2 [Source:HGNC Symbol;Acc:HGNC:11328])

HSP 1 Score: 95.9005 bits (237), Expect = 2.977e-24
Identity = 46/92 (50.00%), Postives = 64/92 (69.57%), Query Frame = 3

Query:   54 EFGDYS-NLVSEAEQKLRNGKRERLNRISSIMGQYLLKGYTMLDETCVSCDTILLRSRQGQYHCVGCLDVDNDTAKDDPAVNMQAAISHFQE 326
            E  D+S    +EAE K+   +RER +RIS +MG YLL+GY ML ETC  C TILL+ +Q + +CV C ++D+D  KD+PA+N QAA+S  +E
Sbjct:    1 EVDDFSWEPPTEAETKVLQARRERQDRISRLMGDYLLRGYRMLGETCADCGTILLQDKQRKIYCVACQELDSDVDKDNPALNAQAALSQARE 92

[Close]

BLAST of Zinc ribbon domain containing 2 vs. Ensembl Human
Match: ZNRD2 (zinc ribbon domain containing 2 [Source:HGNC Symbol;Acc:HGNC:11328])

HSP 1 Score: 75.0998 bits (183), Expect = 1.075e-16
Identity = 33/61 (54.10%), Postives = 45/61 (73.77%), Query Frame = 3

Query:  144 MGQYLLKGYTMLDETCVSCDTILLRSRQGQYHCVGCLDVDNDTAKDDPAVNMQAAISHFQE 326
            MG YLL+GY ML ETC  C TILL+ +Q + +CV C ++D+D  KD+PA+N QAA+S  +E
Sbjct:    1 MGDYLLRGYRMLGETCADCGTILLQDKQRKIYCVACQELDSDVDKDNPALNAQAALSQARE 61

[Close]

BLAST of Zinc ribbon domain containing 2 vs. Ensembl Human
Match: ZNRD2 (zinc ribbon domain containing 2 [Source:HGNC Symbol;Acc:HGNC:11328])

HSP 1 Score: 66.2402 bits (160), Expect = 6.285e-14
Identity = 31/62 (50.00%), Postives = 42/62 (67.74%), Query Frame = 3

Query:  132 ISSIMGQYLLKGYTMLDETCVSCDTILLRSRQGQYHCVGCLDVDNDTAKDDPAVNMQAAISH 317
            IS +MG YLL+GY ML ETC  C TILL+ +Q + +CV C ++D+D  KD+P     AA+ H
Sbjct:    2 ISRLMGDYLLRGYRMLGETCADCGTILLQDKQRKIYCVACQELDSDVDKDNP--GGAAAVGH 61

[Close]

BLAST of Zinc ribbon domain containing 2 vs. Ensembl Human
Match: ZNRD2 (zinc ribbon domain containing 2 [Source:HGNC Symbol;Acc:HGNC:11328])

HSP 1 Score: 62.003 bits (149), Expect = 1.015e-12
Identity = 27/50 (54.00%), Postives = 37/50 (74.00%), Query Frame = 3

Query:  144 MGQYLLKGYTMLDETCVSCDTILLRSRQGQYHCVGCLDVDNDTAKDDPAV 293
            MG YLL+GY ML ETC  C TILL+ +Q + +CV C ++D+D  KD+PA+
Sbjct:    1 MGDYLLRGYRMLGETCADCGTILLQDKQRKIYCVACQELDSDVDKDNPAL 50

[Close]

BLAST of Zinc ribbon domain containing 2 vs. Ensembl Celegans
Match: Y39A1A.3 (pep chromosome:WBcel235:III:10595258:10596487:-1 gene:WBGene00012643.1 transcript:Y39A1A.3.1 gene_biotype:protein_coding transcript_biotype:protein_coding gene_symbol:Y39A1A.3)

HSP 1 Score: 46.2098 bits (108), Expect = 3.703e-6
Identity = 24/55 (43.64%), Postives = 31/55 (56.36%), Query Frame = 3

Query:   87 AEQKLRNGKRERLNRISSIMGQYLLKGYTMLDETCVSCDTILLRSRQGQYHCVGC 251
            A  +LR+  R   + +S  MG+ LLKG TMLDE C +C  IL+  R     CV C
Sbjct:   45 ASIRLRDSFR---DEVSKRMGELLLKGQTMLDEYCPTCSGILMEDRALVRRCVTC 96

[Close]

BLAST of Zinc ribbon domain containing 2 vs. Ensembl Zebrafish
Match: znrd2 (zinc ribbon domain containing 2 [Source:ZFIN;Acc:ZDB-GENE-041010-102])

HSP 1 Score: 91.6633 bits (226), Expect = 1.652e-22
Identity = 43/82 (52.44%), Postives = 59/82 (71.95%), Query Frame = 3

Query:   81 SEAEQKLRNGKRERLNRISSIMGQYLLKGYTMLDETCVSCDTILLRSRQGQYHCVGCLDVDNDTAKDDPAVNMQAAISHFQE 326
            SEAE K+   +RER ++IS +MG YLLKGY ML E C  C TILL+ +Q + +CV C ++D+D  KD+PA+N QAA+S  +E
Sbjct:   16 SEAEMKVIQARRERQDKISKLMGDYLLKGYKMLGECCELCGTILLQDKQKKNYCVACQELDSDVDKDNPALNAQAALSQVRE 97

[Close]

BLAST of Zinc ribbon domain containing 2 vs. Ensembl Zebrafish
Match: znrd2 (zinc ribbon domain containing 2 [Source:ZFIN;Acc:ZDB-GENE-041010-102])

HSP 1 Score: 91.6633 bits (226), Expect = 1.687e-22
Identity = 43/82 (52.44%), Postives = 59/82 (71.95%), Query Frame = 3

Query:   81 SEAEQKLRNGKRERLNRISSIMGQYLLKGYTMLDETCVSCDTILLRSRQGQYHCVGCLDVDNDTAKDDPAVNMQAAISHFQE 326
            SEAE K+   +RER ++IS +MG YLLKGY ML E C  C TILL+ +Q + +CV C ++D+D  KD+PA+N QAA+S  +E
Sbjct:   16 SEAEMKVIQARRERQDKISKLMGDYLLKGYKMLGECCELCGTILLQDKQKKNYCVACQELDSDVDKDNPALNAQAALSQVRE 97

[Close]

BLAST of Zinc ribbon domain containing 2 vs. Ensembl Xenopus
Match: dmtn (dematin actin binding protein [Source:Xenbase;Acc:XB-GENE-982208])

HSP 1 Score: 86.6557 bits (213), Expect = 6.636e-21
Identity = 41/95 (43.16%), Postives = 62/95 (65.26%), Query Frame = 3

Query:   42 KIMAEFGDYSNLVSEAEQKLRNGKRERLNRISSIMGQYLLKGYTMLDETCVSCDTILLRSRQGQYHCVGCLDVDNDTAKDDPAVNMQAAISHFQE 326
               A   D  +  SE++ K+   +RE  +RIS +MG YLLKGY ML ++C +C TILL+ +Q +  C+ C ++D+DT KD+P +N QAA+S  +E
Sbjct:    3 PFFAGDDDSWSPPSESDLKILRARREHQDRISRLMGDYLLKGYRMLGDSCDTCGTILLQDKQKKLLCISCQELDSDTEKDNPVLNHQAALSQVRE 97

[Close]

BLAST of Zinc ribbon domain containing 2 vs. Ensembl Xenopus
Match: dmtn (dematin actin binding protein [Source:Xenbase;Acc:XB-GENE-982208])

HSP 1 Score: 86.6557 bits (213), Expect = 7.055e-21
Identity = 40/88 (45.45%), Postives = 61/88 (69.32%), Query Frame = 3

Query:   63 DYSNLVSEAEQKLRNGKRERLNRISSIMGQYLLKGYTMLDETCVSCDTILLRSRQGQYHCVGCLDVDNDTAKDDPAVNMQAAISHFQE 326
            D  +  SE++ K+   +RE  +RIS +MG YLLKGY ML ++C +C TILL+ +Q +  C+ C ++D+DT KD+P +N QAA+S  +E
Sbjct:    8 DSWSPPSESDLKILRARREHQDRISRLMGDYLLKGYRMLGDSCDTCGTILLQDKQKKLLCISCQELDSDTEKDNPVLNHQAALSQVRE 95

[Close]

BLAST of Zinc ribbon domain containing 2 vs. Ensembl Mouse
Match: Znrd2 (zinc ribbon domain containing 2 [Source:MGI Symbol;Acc:MGI:1913482])

HSP 1 Score: 93.2041 bits (230), Expect = 2.144e-23
Identity = 42/82 (51.22%), Postives = 60/82 (73.17%), Query Frame = 3

Query:   81 SEAEQKLRNGKRERLNRISSIMGQYLLKGYTMLDETCVSCDTILLRSRQGQYHCVGCLDVDNDTAKDDPAVNMQAAISHFQE 326
            +EAE K+   +RER +RIS +MG YLL+GY ML +TC  C TILL+ +Q + +CV C ++D+D  KD+PA+N QAA+S  +E
Sbjct:   17 TEAETKVLQARRERQDRISRLMGDYLLRGYRMLGDTCADCGTILLQDKQRKIYCVACQELDSDVDKDNPALNAQAALSQARE 98

[Close]

BLAST of Zinc ribbon domain containing 2 vs. Ensembl Mouse
Match: Gm50387 (predicted gene, 50387 [Source:MGI Symbol;Acc:MGI:6303289])

HSP 1 Score: 93.2041 bits (230), Expect = 2.144e-23
Identity = 42/82 (51.22%), Postives = 60/82 (73.17%), Query Frame = 3

Query:   81 SEAEQKLRNGKRERLNRISSIMGQYLLKGYTMLDETCVSCDTILLRSRQGQYHCVGCLDVDNDTAKDDPAVNMQAAISHFQE 326
            +EAE K+   +RER +RIS +MG YLL+GY ML +TC  C TILL+ +Q + +CV C ++D+D  KD+PA+N QAA+S  +E
Sbjct:   17 TEAETKVLQARRERQDRISRLMGDYLLRGYRMLGDTCADCGTILLQDKQRKIYCVACQELDSDVDKDNPALNAQAALSQARE 98

[Close]

BLAST of Zinc ribbon domain containing 2 vs. Ensembl Mouse
Match: Znrd2 (zinc ribbon domain containing 2 [Source:MGI Symbol;Acc:MGI:1913482])

HSP 1 Score: 51.6026 bits (122), Expect = 9.616e-9
Identity = 22/40 (55.00%), Postives = 29/40 (72.50%), Query Frame = 3

Query:   81 SEAEQKLRNGKRERLNRISSIMGQYLLKGYTMLDETCVSC 200
            +EAE K+   +RER +RIS +MG YLL+GY ML +TC  C
Sbjct:   17 TEAETKVLQARRERQDRISRLMGDYLLRGYRMLGDTCADC 56

[Close]

BLAST of Zinc ribbon domain containing 2 vs. Ensembl Mouse
Match: Znrd2 (zinc ribbon domain containing 2 [Source:MGI Symbol;Acc:MGI:1913482])

HSP 1 Score: 42.743 bits (99), Expect = 9.958e-6
Identity = 18/39 (46.15%), Postives = 27/39 (69.23%), Query Frame = 3

Query:  174 MLDETCVSCDTILLRSRQGQYHCVGCLDVDNDTAKDDPA 290
            ML +TC  C TILL+ +Q + +CV C ++D+D  KD+P 
Sbjct:    2 MLGDTCADCGTILLQDKQRKIYCVACQELDSDVDKDNPG 40

[Close]

BLAST of Zinc ribbon domain containing 2 vs. UniProt/SwissProt
Match: sp|O60232|ZNRD2_HUMAN (Protein ZNRD2 OS=Homo sapiens OX=9606 GN=ZNRD2 PE=1 SV=1)

HSP 1 Score: 97.4413 bits (241), Expect = 3.748e-24
Identity = 47/93 (50.54%), Postives = 65/93 (69.89%), Query Frame = 3

Query:   51 AEFGDYS-NLVSEAEQKLRNGKRERLNRISSIMGQYLLKGYTMLDETCVSCDTILLRSRQGQYHCVGCLDVDNDTAKDDPAVNMQAAISHFQE 326
            AE  D+S    +EAE K+   +RER +RIS +MG YLL+GY ML ETC  C TILL+ +Q + +CV C ++D+D  KD+PA+N QAA+S  +E
Sbjct:    6 AEVDDFSWEPPTEAETKVLQARRERQDRISRLMGDYLLRGYRMLGETCADCGTILLQDKQRKIYCVACQELDSDVDKDNPALNAQAALSQARE 98

[Close]

BLAST of Zinc ribbon domain containing 2 vs. UniProt/SwissProt
Match: sp|P56873|ZNRD2_MOUSE (Protein ZNRD2 OS=Mus musculus OX=10090 GN=Znrd2 PE=1 SV=1)

HSP 1 Score: 93.2041 bits (230), Expect = 1.500e-22
Identity = 42/82 (51.22%), Postives = 60/82 (73.17%), Query Frame = 3

Query:   81 SEAEQKLRNGKRERLNRISSIMGQYLLKGYTMLDETCVSCDTILLRSRQGQYHCVGCLDVDNDTAKDDPAVNMQAAISHFQE 326
            +EAE K+   +RER +RIS +MG YLL+GY ML +TC  C TILL+ +Q + +CV C ++D+D  KD+PA+N QAA+S  +E
Sbjct:   17 TEAETKVLQARRERQDRISRLMGDYLLRGYRMLGDTCADCGTILLQDKQRKIYCVACQELDSDVDKDNPALNAQAALSQARE 98

[Close]

BLAST of Zinc ribbon domain containing 2 vs. TrEMBL
Match: A0A1S3KFF6 (Sjoegren syndrome/scleroderma autoantigen 1 isoform X1 OS=Lingula unguis OX=7574 GN=LOC106181516 PE=4 SV=1)

HSP 1 Score: 102.064 bits (253), Expect = 8.865e-24
Identity = 50/82 (60.98%), Postives = 61/82 (74.39%), Query Frame = 3

Query:   81 SEAEQKLRNGKRERLNRISSIMGQYLLKGYTMLDETCVSCDTILLRSRQGQYHCVGCLDVDNDTAKDDPAVNMQAAISHFQE 326
            SEAE KL   +RER ++IS IMG YLLKGY ML  +C  C TILLR RQ Q +CVGC D+++DT KD+PAVN +AA SH +E
Sbjct:   13 SEAEMKLIQARRERSDKISKIMGDYLLKGYKMLGSSCELCGTILLRDRQSQDYCVGCNDLESDTDKDNPAVNTEAARSHERE 94

[Close]

BLAST of Zinc ribbon domain containing 2 vs. TrEMBL
Match: L5LE88 (Sjoegren syndrome/scleroderma autoantigen 1 OS=Myotis davidii OX=225400 GN=MDA_GLEAN10017904 PE=4 SV=1)

HSP 1 Score: 102.064 bits (253), Expect = 1.910e-23
Identity = 49/93 (52.69%), Postives = 67/93 (72.04%), Query Frame = 3

Query:   51 AEFGDYS-NLVSEAEQKLRNGKRERLNRISSIMGQYLLKGYTMLDETCVSCDTILLRSRQGQYHCVGCLDVDNDTAKDDPAVNMQAAISHFQE 326
            AE  D+S    +EAE K+   +RER NRISS+MG YLL+GY ML +TC  C TILL+++Q Q +CV C ++D+D  KD+PA+N QAA+S  +E
Sbjct:    6 AEVDDFSWEPPTEAETKVLQARRERQNRISSLMGDYLLRGYRMLGDTCADCGTILLQNKQRQTYCVACQELDSDVDKDNPALNAQAALSQARE 98

[Close]

BLAST of Zinc ribbon domain containing 2 vs. TrEMBL
Match: G1Q0A7 (Zinc ribbon domain containing 2 OS=Myotis lucifugus OX=59463 GN=ZNRD2 PE=4 SV=1)

HSP 1 Score: 102.064 bits (253), Expect = 1.931e-23
Identity = 49/93 (52.69%), Postives = 67/93 (72.04%), Query Frame = 3

Query:   51 AEFGDYS-NLVSEAEQKLRNGKRERLNRISSIMGQYLLKGYTMLDETCVSCDTILLRSRQGQYHCVGCLDVDNDTAKDDPAVNMQAAISHFQE 326
            AE  D+S    +EAE K+   +RER NRISS+MG YLL+GY ML +TC  C TILL+++Q Q +CV C ++D+D  KD+PA+N QAA+S  +E
Sbjct:    6 AEVDDFSWEPPTEAETKVLQARRERQNRISSLMGDYLLRGYRMLGDTCADCGTILLQNKQRQTYCVACQELDSDVDKDNPALNAQAALSQARE 98

[Close]

BLAST of Zinc ribbon domain containing 2 vs. TrEMBL
Match: S7MQF7 (Sjoegren syndrome/scleroderma autoantigen 1 OS=Myotis brandtii OX=109478 GN=D623_10030722 PE=4 SV=1)

HSP 1 Score: 102.064 bits (253), Expect = 1.973e-23
Identity = 49/93 (52.69%), Postives = 67/93 (72.04%), Query Frame = 3

Query:   51 AEFGDYS-NLVSEAEQKLRNGKRERLNRISSIMGQYLLKGYTMLDETCVSCDTILLRSRQGQYHCVGCLDVDNDTAKDDPAVNMQAAISHFQE 326
            AE  D+S    +EAE K+   +RER NRISS+MG YLL+GY ML +TC  C TILL+++Q Q +CV C ++D+D  KD+PA+N QAA+S  +E
Sbjct:    6 AEVDDFSWEPPTEAETKVLQARRERQNRISSLMGDYLLRGYRMLGDTCADCGTILLQNKQRQTYCVACQELDSDVDKDNPALNAQAALSQARE 98

[Close]

BLAST of Zinc ribbon domain containing 2 vs. TrEMBL
Match: S4RZQ1 (Zinc ribbon domain containing 2 OS=Petromyzon marinus OX=7757 PE=4 SV=1)

HSP 1 Score: 98.9821 bits (245), Expect = 5.798e-22
Identity = 45/82 (54.88%), Postives = 62/82 (75.61%), Query Frame = 3

Query:   81 SEAEQKLRNGKRERLNRISSIMGQYLLKGYTMLDETCVSCDTILLRSRQGQYHCVGCLDVDNDTAKDDPAVNMQAAISHFQE 326
            SEAE K+   +RER ++IS IMG+YLLKGY ML E+C  C TILL+ RQ + +CV C+++D+D  KD+PA+N QAA+S  +E
Sbjct:   17 SEAEMKVMTARRERQDKISKIMGEYLLKGYKMLGESCDECGTILLQDRQRKNYCVACMELDSDVDKDNPALNPQAALSQVRE 98

[Close]

BLAST of Zinc ribbon domain containing 2 vs. Ensembl Cavefish
Match: znrd2 (zinc ribbon domain containing 2 [Source:NCBI gene;Acc:103027163])

HSP 1 Score: 90.8929 bits (224), Expect = 2.535e-22
Identity = 42/82 (51.22%), Postives = 59/82 (71.95%), Query Frame = 3

Query:   81 SEAEQKLRNGKRERLNRISSIMGQYLLKGYTMLDETCVSCDTILLRSRQGQYHCVGCLDVDNDTAKDDPAVNMQAAISHFQE 326
            +EAE K+   +RER ++IS +MG YLLKGY ML E C  C TILL+ +Q + +CV C ++D+D  KD+PA+N QAA+S  +E
Sbjct:   16 TEAEMKVIQARRERQDKISKLMGDYLLKGYKMLGECCELCGTILLQDKQKKNYCVACQELDSDVDKDNPALNAQAALSQVRE 97

[Close]

BLAST of Zinc ribbon domain containing 2 vs. Ensembl Cavefish
Match: znrd2 (zinc ribbon domain containing 2 [Source:NCBI gene;Acc:103027163])

HSP 1 Score: 90.8929 bits (224), Expect = 9.415e-22
Identity = 42/82 (51.22%), Postives = 59/82 (71.95%), Query Frame = 3

Query:   81 SEAEQKLRNGKRERLNRISSIMGQYLLKGYTMLDETCVSCDTILLRSRQGQYHCVGCLDVDNDTAKDDPAVNMQAAISHFQE 326
            +EAE K+   +RER ++IS +MG YLLKGY ML E C  C TILL+ +Q + +CV C ++D+D  KD+PA+N QAA+S  +E
Sbjct:   93 TEAEMKVIQARRERQDKISKLMGDYLLKGYKMLGECCELCGTILLQDKQKKNYCVACQELDSDVDKDNPALNAQAALSQVRE 174

[Close]

BLAST of Zinc ribbon domain containing 2 vs. Ensembl Sea Lamprey
Match: znrd2 (zinc ribbon domain containing 2 [Source:ZFIN;Acc:ZDB-GENE-041010-102])

HSP 1 Score: 98.9821 bits (245), Expect = 4.454e-26
Identity = 45/82 (54.88%), Postives = 62/82 (75.61%), Query Frame = 3

Query:   81 SEAEQKLRNGKRERLNRISSIMGQYLLKGYTMLDETCVSCDTILLRSRQGQYHCVGCLDVDNDTAKDDPAVNMQAAISHFQE 326
            SEAE K+   +RER ++IS IMG+YLLKGY ML E+C  C TILL+ RQ + +CV C+++D+D  KD+PA+N QAA+S  +E
Sbjct:   17 SEAEMKVMTARRERQDKISKIMGEYLLKGYKMLGESCDECGTILLQDRQRKNYCVACMELDSDVDKDNPALNPQAALSQVRE 98

[Close]

BLAST of Zinc ribbon domain containing 2 vs. Ensembl Nematostella
Match: EDO41228 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7S4X2])

HSP 1 Score: 65.0846 bits (157), Expect = 1.457e-13
Identity = 32/80 (40.00%), Postives = 48/80 (60.00%), Query Frame = 3

Query:   90 EQKLRNGKRERLNRISSIMGQYLLKGYTMLDETCVSCDTILLRSRQGQYHCVGC--LDVDN---DTAKDDPAVNMQAAIS 314
            +Q + N +RER ++IS +MG Y+L+GY ML   C +C T+LL+ R+   +CV C  +DVDN    T K  PA+     + 
Sbjct:    2 DQDMYNRRRERTDKISGLMGSYMLRGYKMLGTCCDTCGTVLLKYREEPDYCVACKEVDVDNMPKPTEKGPPAMRQTPPLP 81

[Close]

BLAST of Zinc ribbon domain containing 2 vs. Ensembl Medaka
Match: znrd2 (zinc ribbon domain containing 2 [Source:NCBI gene;Acc:101174689])

HSP 1 Score: 90.8929 bits (224), Expect = 2.718e-22
Identity = 42/82 (51.22%), Postives = 60/82 (73.17%), Query Frame = 3

Query:   81 SEAEQKLRNGKRERLNRISSIMGQYLLKGYTMLDETCVSCDTILLRSRQGQYHCVGCLDVDNDTAKDDPAVNMQAAISHFQE 326
            +EAE K+   +RER ++IS +MG YLLKGY ML + C +C TILL+ RQ + +CV C ++D+D  KD+PA+N QAA+S  +E
Sbjct:   16 TEAEMKVIQARRERQDKISRLMGDYLLKGYKMLGDCCDACGTILLQDRQQKNYCVSCQEMDSDIDKDNPALNAQAALSQVRE 97

[Close]

BLAST of Zinc ribbon domain containing 2 vs. Planmine SMEST
Match: SMESG000080952.1 (SMESG000080952.1)

HSP 1 Score: 292.738 bits (748), Expect = 1.468e-102
Identity = 158/158 (100.00%), Postives = 158/158 (100.00%), Query Frame = 3

Query:   48 MAEFGDYSNLVSEAEQKLRNGKRERLNRISSIMGQYLLKGYTMLDETCVSCDTILLRSRQGQYHCVGCLDVDNDTAKDDPAVNMQAAISHFQELKSTCSKDIIDNISSIQKVEQILKEKXXXXXXXXXXXXXVEYEIKLTKLIQILIETLGYINKMKL 521
            MAEFGDYSNLVSEAEQKLRNGKRERLNRISSIMGQYLLKGYTMLDETCVSCDTILLRSRQGQYHCVGCLDVDNDTAKDDPAVNMQAAISHFQELKSTCSKDIIDNISSIQKVEQILKEKLLSTSILLTDSTDVEYEIKLTKLIQILIETLGYINKMKL
Sbjct:    1 MAEFGDYSNLVSEAEQKLRNGKRERLNRISSIMGQYLLKGYTMLDETCVSCDTILLRSRQGQYHCVGCLDVDNDTAKDDPAVNMQAAISHFQELKSTCSKDIIDNISSIQKVEQILKEKLLSTSILLTDSTDVEYEIKLTKLIQILIETLGYINKMKL 158

The following BLAST results are available for this feature:

BLAST of Zinc ribbon domain containing 2 vs. Ensembl Human
BLAST of Zinc ribbon domain containing 2 vs. Ensembl Celegans
BLAST of Zinc ribbon domain containing 2 vs. Ensembl Fly
BLAST of Zinc ribbon domain containing 2 vs. Ensembl Zebrafish
BLAST of Zinc ribbon domain containing 2 vs. Ensembl Xenopus
BLAST of Zinc ribbon domain containing 2 vs. Ensembl Mouse
BLAST of Zinc ribbon domain containing 2 vs. UniProt/SwissProt
BLAST of Zinc ribbon domain containing 2 vs. TrEMBL
BLAST of Zinc ribbon domain containing 2 vs. Ensembl Cavefish
BLAST of Zinc ribbon domain containing 2 vs. Ensembl Sea Lamprey
BLAST of Zinc ribbon domain containing 2 vs. Ensembl Yeast
BLAST of Zinc ribbon domain containing 2 vs. Ensembl Nematostella
BLAST of Zinc ribbon domain containing 2 vs. Ensembl Medaka
BLAST of Zinc ribbon domain containing 2 vs. Planmine SMEST

BLAST of Zinc ribbon domain containing 2 vs. Ensembl Human
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Human e!99)
Total hits: 5


Match Name	E-value	Identity	Description
ZNRD2	7.804e-25	50.54	zinc ribbon domain containing 2 [Source:HGNC Symbo...	[more]
ZNRD2	2.977e-24	50.00	zinc ribbon domain containing 2 [Source:HGNC Symbo...	[more]
ZNRD2	1.075e-16	54.10	zinc ribbon domain containing 2 [Source:HGNC Symbo...	[more]
ZNRD2	6.285e-14	50.00	zinc ribbon domain containing 2 [Source:HGNC Symbo...	[more]
ZNRD2	1.015e-12	54.00	zinc ribbon domain containing 2 [Source:HGNC Symbo...	[more]

BLAST of Zinc ribbon domain containing 2 vs. Ensembl Celegans
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99)
Total hits: 1


Match Name	E-value	Identity	Description
Y39A1A.3	3.703e-6	43.64	pep chromosome:WBcel235:III:10595258:10596487:-1 g...	[more]

BLAST of Zinc ribbon domain containing 2 vs. Ensembl Fly
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99)
Total hits: 0


Match Name	E-value	Identity	Description

BLAST of Zinc ribbon domain containing 2 vs. Ensembl Zebrafish
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99)
Total hits: 2


Match Name	E-value	Identity	Description
znrd2	1.652e-22	52.44	zinc ribbon domain containing 2 [Source:ZFIN;Acc:Z...	[more]
znrd2	1.687e-22	52.44	zinc ribbon domain containing 2 [Source:ZFIN;Acc:Z...	[more]

BLAST of Zinc ribbon domain containing 2 vs. Ensembl Xenopus
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99)
Total hits: 2


Match Name	E-value	Identity	Description
dmtn	6.636e-21	43.16	dematin actin binding protein [Source:Xenbase;Acc:...	[more]
dmtn	7.055e-21	45.45	dematin actin binding protein [Source:Xenbase;Acc:...	[more]

BLAST of Zinc ribbon domain containing 2 vs. Ensembl Mouse
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99)
Total hits: 4


Match Name	E-value	Identity	Description
Znrd2	2.144e-23	51.22	zinc ribbon domain containing 2 [Source:MGI Symbol...	[more]
Gm50387	2.144e-23	51.22	predicted gene, 50387 [Source:MGI Symbol;Acc:MGI:6...	[more]
Znrd2	9.616e-9	55.00	zinc ribbon domain containing 2 [Source:MGI Symbol...	[more]
Znrd2	9.958e-6	46.15	zinc ribbon domain containing 2 [Source:MGI Symbol...	[more]

BLAST of Zinc ribbon domain containing 2 vs. UniProt/SwissProt
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt)
Total hits: 2


Match Name	E-value	Identity	Description
sp\|O60232\|ZNRD2_HUMAN	3.748e-24	50.54	Protein ZNRD2 OS=Homo sapiens OX=9606 GN=ZNRD2 PE=...	[more]
sp\|P56873\|ZNRD2_MOUSE	1.500e-22	51.22	Protein ZNRD2 OS=Mus musculus OX=10090 GN=Znrd2 PE...	[more]

BLAST of Zinc ribbon domain containing 2 vs. TrEMBL
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL)
Total hits: 5


Match Name	E-value	Identity	Description
A0A1S3KFF6	8.865e-24	60.98	Sjoegren syndrome/scleroderma autoantigen 1 isofor...	[more]
L5LE88	1.910e-23	52.69	Sjoegren syndrome/scleroderma autoantigen 1 OS=Myo...	[more]
G1Q0A7	1.931e-23	52.69	Zinc ribbon domain containing 2 OS=Myotis lucifugu...	[more]
S7MQF7	1.973e-23	52.69	Sjoegren syndrome/scleroderma autoantigen 1 OS=Myo...	[more]
S4RZQ1	5.798e-22	54.88	Zinc ribbon domain containing 2 OS=Petromyzon mari...	[more]

BLAST of Zinc ribbon domain containing 2 vs. Ensembl Cavefish
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99)
Total hits: 2


Match Name	E-value	Identity	Description
znrd2	2.535e-22	51.22	zinc ribbon domain containing 2 [Source:NCBI gene;...	[more]
znrd2	9.415e-22	51.22	zinc ribbon domain containing 2 [Source:NCBI gene;...	[more]

BLAST of Zinc ribbon domain containing 2 vs. Ensembl Sea Lamprey
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99)
Total hits: 1


Match Name	E-value	Identity	Description
znrd2	4.454e-26	54.88	zinc ribbon domain containing 2 [Source:ZFIN;Acc:Z...	[more]

BLAST of Zinc ribbon domain containing 2 vs. Ensembl Yeast
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46)
Total hits: 0


Match Name	E-value	Identity	Description

BLAST of Zinc ribbon domain containing 2 vs. Ensembl Nematostella
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46)
Total hits: 1


Match Name	E-value	Identity	Description
EDO41228	1.457e-13	40.00	Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7...	[more]

BLAST of Zinc ribbon domain containing 2 vs. Ensembl Medaka
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99)
Total hits: 1


Match Name	E-value	Identity	Description
znrd2	2.718e-22	51.22	zinc ribbon domain containing 2 [Source:NCBI gene;...	[more]

BLAST of Zinc ribbon domain containing 2 vs. Planmine SMEST
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST)
Total hits: 1


Match Name	E-value	Identity	Description
SMESG000080952.1	1.468e-102	100.00	SMESG000080952.1	[more]

Analyses

This transcript is derived from or has results from the following analyses


Analysis Name	Date Performed
Embryonic Stages	2016-07-25
Schmidtea mediterranea smed_20140614 BLASTX Human e!99	2016-08-08
Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99	2016-08-08
Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL	2020-05-01
Schmidtea mediterranea Sexual smed_20140614 transcriptome	2016-07-25
Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST	2020-05-08

Sequences

The following sequences are available for this feature:

transcript sequence
protein sequence

transcript sequence

>SMED30010888 ID=SMED30010888|Name=Zinc ribbon domain containing 2|organism=Schmidtea mediterranea sexual|type=transcript|length=597bp
TAATATTACAAATTTACATTACTTGATATTTTATTTGAAATAAAATAATG
GCAGAATTTGGTGATTATTCAAATTTGGTGTCTGAAGCAGAACAAAAATT
AAGAAATGGAAAAAGAGAAAGGTTGAATAGAATATCATCTATTATGGGAC
AATATTTACTTAAAGGCTATACGATGTTAGATGAAACCTGTGTGTCTTGC
GACACTATTCTTCTTCGAAGTAGACAGGGTCAATATCATTGTGTGGGATG
TTTAGATGTCGACAATGATACTGCTAAAGATGACCCTGCAGTTAATATGC
AAGCTGCAATATCGCATTTCCAAGAGCTTAAATCCACCTGTTCCAAAGAT
ATTATTGATAATATATCATCTATTCAAAAAGTTGAACAGATTTTAAAAGA
GAAACTACTGTCTACTTCGATTTTGCTAACTGATTCTACAGATGTCGAAT
ATGAAATAAAACTAACAAAGCTAATTCAAATTTTAATTGAAACGCTTGGT
TATATAAATAAAATGAAATTGTAATTTTTGGTTAACTTTTTATTTAGAAA
AATTGTTATTGTTAATATAAATTTAATTATATAAATGAATGATGTTG

protein sequence of SMED30010888-orf-1

>SMED30010888-orf-1 ID=SMED30010888-orf-1|Name=SMED30010888-orf-1|organism=Schmidtea mediterranea sexual|type=polypeptide|length=159bp
MAEFGDYSNLVSEAEQKLRNGKRERLNRISSIMGQYLLKGYTMLDETCVS
CDTILLRSRQGQYHCVGCLDVDNDTAKDDPAVNMQAAISHFQELKSTCSK
DIIDNISSIQKVEQILKEKLLSTSILLTDSTDVEYEIKLTKLIQILIETL
GYINKMKL*

Annotated Terms

The following terms have been associated with this transcript:

Vocabulary: **Planarian Anatomy**
Term	Definition
PLANA:0002109	X1 cell

Vocabulary: **INTERPRO**
Term	Definition
IPR009563	SSSCA1

Vocabulary: **molecular function**
Term	Definition
GO:0005515	protein binding
GO:0042802	identical protein binding

Vocabulary: **biological process**
Term	Definition
GO:0007049	cell cycle
GO:0007067	mitotic nuclear division
GO:0051301	cell division

Main menu

Zinc ribbon domain containing 2

Zeng et. al., 2018

▻ Overview

▻ Neoblast Population

▻ Sub-lethal Irradiated Surviving X1 and X2 Cell Population

Overview

Single cell RNA-seq of pluripotent neoblasts and its early progenies

Explore this single cell expression dataset with our NB Cluster Shiny App

Neoblast Population

Sub-lethal Irradiated Surviving X1 and X2 Cell Population

Davies et. al., 2017

PAGE et. al., 2020

has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGE

PAGE Curations: 2

Owlery

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