Calcium load-activated calcium channel

Overview
NameCalcium load-activated calcium channel
Smed IDSMED30010877
Length (bp)1126
Neoblast Clusters

Zeng et. al., 2018



▻ Overview

▻ Neoblast Population

▻ Sub-lethal Irradiated Surviving X1 and X2 Cell Population

 

 

Overview

 

Single cell RNA-seq of pluripotent neoblasts and its early progenies


We isolated X1 neoblasts cells enriched in high piwi-1 expression (Neoblast Population), and profiled ∼7,614 individual cells via scRNA-seq. Unsupervised analyses uncovered 12 distinct classes from 7,088 high-quality cells. We designated these classes Nb1 to Nb12 and ordered them based on high (Nb1) to low (Nb12) piwi-1 expression levels. We further defined groups of genes that best classified the cells parsed into 12 distinct cell clusters to generate a scaled expression heat map of discriminative gene sets for each cluster. Expression of each cluster’s gene signatures was validated using multiplex fluorescence in situ hybridization (FISH) co-stained with piwi-1 and largely confirmed the cell clusters revealed by scRNA-seq.

We also tested sub-lethal irradiation exposure. To profile rare pluripotent stem cells (PSCs) and avoid interference from immediate progenitor cells, we determined a time point after sub-lethal irradiation (7 DPI) with minimal piwi-1+ cells, followed by isolation and single-cell RNA-seq of 1,200 individual cells derived from X1 (Piwi-1 high) and X2 (Piwi-1 low) cell populations (Sub-lethal Irradiated Surviving X1 and X2 Cell Population)



Explore this single cell expression dataset with our NB Cluster Shiny App



 

Neoblast Population

 

t-SNE plot shows two-dimensional representation of global gene expression relationships among all neoblasts (n = 7,088 after filter). Cluster identity was assigned based on the top 10 marker genes of each cluster (Table S2), followed by inspection of RNA in situ hybridization patterns. Neoblast groups, Nb.


Expression of Calcium load-activated calcium channel (SMED30010877) t-SNE clustered cells

Violin plots show distribution of expression levels for Calcium load-activated calcium channel (SMED30010877) in cells (dots) of each of the 12 neoblast clusters.

 

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Sub-lethal Irradiated Surviving X1 and X2 Cell Population

 

t-SNE plot of surviving X1 and X2 cells (n = 1,039 after QC filter) after sub-lethal irradiation. Colors indicate unbiased cell classification via graph-based clustering. SL, sub-lethal irradiated cell groups.

Expression of Calcium load-activated calcium channel (SMED30010877) in the t-SNE clustered sub-lethally irradiated X1 and X2 cells.

Violin plots show distribution of expression levels for Calcium load-activated calcium channel (SMED30010877) in cells (dots) of each of the 10 clusters of sub-leathally irradiated X1 and X2 cells.

 

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Embryonic Expression

Davies et. al., 2017

Hover the mouse over a column in the graph to view average RPKM values per sample.
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Embryonic Stages: Y: yolk. S2-S8: Stages 2-8. C4: asexual adult. SX: virgin, sexually mature adult.
For further information about sample preparation and analysis for the single animal RNA-Seq experiment, please refer to the Materials and Methods

 

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Anatomical Expression

PAGE et. al., 2020



SMED30010877

has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGE



PAGE Curations: 4

  
Expressed InReference TranscriptGene ModelsPublished TranscriptTranscriptomePublicationSpecimenLifecycleEvidence
posterior sideSMED30010877SMESG000016852.1 dd_Smed_v4_2854_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018		FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
posterior muscle cellSMED30010877SMESG000016852.1 dd_Smed_v4_2854_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018		FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
Smed sexual biotypeSMED30010877SMESG000016854.1 Contig29580newmark_estsPMID:29674431
Fincher et al., 2018		FACS sorted cell population adult hermaphrodite single-cell RNA-sequencing evidence
Smed sexual biotypeSMED30010877SMESG000016854.1 Contig29580uc_Smed_v2PMID:29674431
Fincher et al., 2018		FACS sorted cell population adult hermaphrodite single-cell RNA-sequencing evidence
Note: Hover over icons to view figure legend
Homology
[Close]
BLAST of Calcium load-activated calcium channel vs. Ensembl Human
Match: TMCO1 (transmembrane and coiled-coil domains 1 [Source:HGNC Symbol;Acc:HGNC:18188])

HSP 1 Score: 210.69 bits (535), Expect = 1.063e-66
Identity = 121/173 (69.94%), Postives = 146/173 (84.39%), Query Frame = 2 
Query:   50 MIQDTLLIVFISFFTAFLGEGLTWLLIYRTEKYKRLKTEVDKQSKKLEKQRDDFVETISDKNAXXXXXXXXXXXXNFNRDLSTVKMKSMFVIGLAFTAFVSMFSSIFEGRIVCRLPFTPISFLQGLSHRNLAGDDYTECSFIFLYIICTMSIRQNVQKLLGFAPSRAANKQHG 568
            M  DTLLIVFIS  TA L EG+TW+L+YRT+KYKRLK EV+KQSKKLEK+++   E+ + +  KKK+ERQEEKLKN NRDLS V+MKSMF IG  FTA + MF+SIF+GR+V +LPFTP+S++QGLSHRNL GDD T+CSFIFLYI+CTMSIRQN+QK+LG APSRAA KQ G
Sbjct:    4 MFADTLLIVFISVCTALLAEGITWVLVYRTDKYKRLKAEVEKQSKKLEKKKETITES-AGRQQKKKIERQEEKLKNNNRDLSMVRMKSMFAIGFCFTALMGMFNSIFDGRVVAKLPFTPLSYIQGLSHRNLLGDDTTDCSFIFLYILCTMSIRQNIQKILGLAPSRAATKQAG 175
[Close]
BLAST of Calcium load-activated calcium channel vs. Ensembl Human
Match: TMCO1 (transmembrane and coiled-coil domains 1 [Source:HGNC Symbol;Acc:HGNC:18188])

HSP 1 Score: 209.92 bits (533), Expect = 9.129e-66
Identity = 121/173 (69.94%), Postives = 146/173 (84.39%), Query Frame = 2 
Query:   50 MIQDTLLIVFISFFTAFLGEGLTWLLIYRTEKYKRLKTEVDKQSKKLEKQRDDFVETISDKNAXXXXXXXXXXXXNFNRDLSTVKMKSMFVIGLAFTAFVSMFSSIFEGRIVCRLPFTPISFLQGLSHRNLAGDDYTECSFIFLYIICTMSIRQNVQKLLGFAPSRAANKQHG 568
            M  DTLLIVFIS  TA L EG+TW+L+YRT+KYKRLK EV+KQSKKLEK+++   E+ + +  KKK+ERQEEKLKN NRDLS V+MKSMF IG  FTA + MF+SIF+GR+V +LPFTP+S++QGLSHRNL GDD T+CSFIFLYI+CTMSIRQN+QK+LG APSRAA KQ G
Sbjct:   55 MFADTLLIVFISVCTALLAEGITWVLVYRTDKYKRLKAEVEKQSKKLEKKKETITES-AGRQQKKKIERQEEKLKNNNRDLSMVRMKSMFAIGFCFTALMGMFNSIFDGRVVAKLPFTPLSYIQGLSHRNLLGDDTTDCSFIFLYILCTMSIRQNIQKILGLAPSRAATKQAG 226
[Close]
BLAST of Calcium load-activated calcium channel vs. Ensembl Human
Match: TMCO1 (transmembrane and coiled-coil domains 1 [Source:HGNC Symbol;Acc:HGNC:18188])

HSP 1 Score: 209.92 bits (533), Expect = 9.129e-66
Identity = 121/173 (69.94%), Postives = 146/173 (84.39%), Query Frame = 2 
Query:   50 MIQDTLLIVFISFFTAFLGEGLTWLLIYRTEKYKRLKTEVDKQSKKLEKQRDDFVETISDKNAXXXXXXXXXXXXNFNRDLSTVKMKSMFVIGLAFTAFVSMFSSIFEGRIVCRLPFTPISFLQGLSHRNLAGDDYTECSFIFLYIICTMSIRQNVQKLLGFAPSRAANKQHG 568
            M  DTLLIVFIS  TA L EG+TW+L+YRT+KYKRLK EV+KQSKKLEK+++   E+ + +  KKK+ERQEEKLKN NRDLS V+MKSMF IG  FTA + MF+SIF+GR+V +LPFTP+S++QGLSHRNL GDD T+CSFIFLYI+CTMSIRQN+QK+LG APSRAA KQ G
Sbjct:   55 MFADTLLIVFISVCTALLAEGITWVLVYRTDKYKRLKAEVEKQSKKLEKKKETITES-AGRQQKKKIERQEEKLKNNNRDLSMVRMKSMFAIGFCFTALMGMFNSIFDGRVVAKLPFTPLSYIQGLSHRNLLGDDTTDCSFIFLYILCTMSIRQNIQKILGLAPSRAATKQAG 226
[Close]
BLAST of Calcium load-activated calcium channel vs. Ensembl Human
Match: TMCO1 (transmembrane and coiled-coil domains 1 [Source:HGNC Symbol;Acc:HGNC:18188])

HSP 1 Score: 154.066 bits (388), Expect = 2.394e-45
Identity = 93/136 (68.38%), Postives = 116/136 (85.29%), Query Frame = 2 
Query:  101 LGEGLTWLLIYRTEKYKRLKTEVDKQSKKLEKQRDDFVETISDKNAXXXXXXXXXXXXNFNRDLSTVKMKSMFVIGLAFTAFVSMFSSIFEGRIVCRLPFTPISFLQGLSHRNLAGDDYTECSFIFLYIICTMSIR 508
            L  G+TW+L+YRT+KYKRLK EV+KQSKKLEK+++   E+ + +  KKK+ERQEEKLKN NRDLS V+MKSMF IG  FTA + MF+SIF+GR+V +LPFTP+S++QGLSHRNL GDD T+CSFIFLYI+CTMSIR
Sbjct:    9 LVSGITWVLVYRTDKYKRLKAEVEKQSKKLEKKKETITES-AGRQQKKKIERQEEKLKNNNRDLSMVRMKSMFAIGFCFTALMGMFNSIFDGRVVAKLPFTPLSYIQGLSHRNLLGDDTTDCSFIFLYILCTMSIR 143
[Close]
BLAST of Calcium load-activated calcium channel vs. Ensembl Human
Match: TMCO1 (transmembrane and coiled-coil domains 1 [Source:HGNC Symbol;Acc:HGNC:18188])

HSP 1 Score: 149.058 bits (375), Expect = 5.465e-44
Identity = 66/90 (73.33%), Postives = 79/90 (87.78%), Query Frame = 2 
Query:  299 VKMKSMFVIGLAFTAFVSMFSSIFEGRIVCRLPFTPISFLQGLSHRNLAGDDYTECSFIFLYIICTMSIRQNVQKLLGFAPSRAANKQHG 568
            V+MKSMF IG  FTA + MF+SIF+GR+V +LPFTP+S++QGLSHRNL GDD T+CSFIFLYI+CTMSIRQN+QK+LG APSRAA KQ G
Sbjct:    2 VRMKSMFAIGFCFTALMGMFNSIFDGRVVAKLPFTPLSYIQGLSHRNLLGDDTTDCSFIFLYILCTMSIRQNIQKILGLAPSRAATKQAG 91
[Close]
BLAST of Calcium load-activated calcium channel vs. Ensembl Celegans
Match: F22B5.10 (Calcium load-activated calcium channel homolog [Source:UniProtKB/Swiss-Prot;Acc:Q19714])

HSP 1 Score: 201.06 bits (510), Expect = 2.042e-63
Identity = 111/172 (64.53%), Postives = 144/172 (83.72%), Query Frame = 2 
Query:   50 MIQDTLLIVFISFFTAFLGEGLTWLLIYRTEKYKRLKTEVDKQSKKLEKQRDDFVETISDKNAXXXXXXXXXXXXNFNRDLSTVKMKSMFVIGLAFTAFVSMFSSIFEGRIVCRLPFTPISFLQGLSHRNLAGDDYTECSFIFLYIICTMSIRQNVQKLLGFAPSRAANKQH 565
            M+ D LLI+ I+F TA  GEG+TWLL+YR++ YKRLK ++DK++KKLEK++ +  +T +DKN K+KLER+EE+LK  NRD+S  KMKSMF IGLAFTA +S F+SIFEGR+V +LPF PI F+QGLSHRNL G+D T+CSFIFLYI+CTM++RQN+QK+LGFAPSRA  +Q 
Sbjct:    1 MLGDCLLIIAIAFGTALAGEGITWLLVYRSDHYKRLKADMDKKTKKLEKKKQEVGDT-NDKNIKRKLEREEERLKATNRDMSMFKMKSMFAIGLAFTALLSTFNSIFEGRVVAKLPFYPIGFIQGLSHRNLIGEDMTDCSFIFLYILCTMTVRQNLQKILGFAPSRAMARQQ 171
[Close]
BLAST of Calcium load-activated calcium channel vs. Ensembl Fly
Match: CG10470 (gene:FBgn0032746 transcript:FBtr0081146)

HSP 1 Score: 241.891 bits (616), Expect = 2.764e-79
Identity = 125/171 (73.10%), Postives = 153/171 (89.47%), Query Frame = 2 
Query:   50 MIQDTLLIVFISFFTAFLGEGLTWLLIYRTEKYKRLKTEVDKQSKKLEKQRDDFVETISDKNAXXXXXXXXXXXXNFNRDLSTVKMKSMFVIGLAFTAFVSMFSSIFEGRIVCRLPFTPISFLQGLSHRNLAGDDYTECSFIFLYIICTMSIRQNVQKLLGFAPSRAANKQ 562
            M  DT+LIVFIS  TAFLGEGLTW+++YRTEKY++LKTEV+KQSKKLE++++   +++ DK  KKK+ER EEKLKN NRDLS VKMK+MF  G AFTA +SMF+SIF+GR+V +LPFTPIS++QGLSHRNL+GDDYT+CSFIFLYI+CTMSIRQN+QKLLGFAPSRAA+KQ
Sbjct:    1 MWSDTILIVFISVCTAFLGEGLTWVMVYRTEKYQKLKTEVEKQSKKLERRKEIHGDSL-DKAVKKKIERDEEKLKNNNRDLSLVKMKTMFATGFAFTALLSMFNSIFDGRVVAQLPFTPISWIQGLSHRNLSGDDYTDCSFIFLYILCTMSIRQNIQKLLGFAPSRAASKQ 170
[Close]
BLAST of Calcium load-activated calcium channel vs. Ensembl Zebrafish
Match: tmco1 (transmembrane and coiled-coil domains 1 [Source:NCBI gene;Acc:378980])

HSP 1 Score: 210.305 bits (534), Expect = 9.251e-67
Identity = 119/173 (68.79%), Postives = 146/173 (84.39%), Query Frame = 2 
Query:   50 MIQDTLLIVFISFFTAFLGEGLTWLLIYRTEKYKRLKTEVDKQSKKLEKQRDDFVETISDKNAXXXXXXXXXXXXNFNRDLSTVKMKSMFVIGLAFTAFVSMFSSIFEGRIVCRLPFTPISFLQGLSHRNLAGDDYTECSFIFLYIICTMSIRQNVQKLLGFAPSRAANKQHG 568
            M  DT+LIVFIS  TA L EG+TW+L+YRT+KYKRLK EV+KQSKKLEK+++   E+ + +  KKK+ERQEEKLKN NRDLS V+MKSMF IG  FTA + MF+SIF+GR+V +LPF P+S++QGLSHRNL G+DYT+CSFIFLYI+CTMSIRQN+QK+LG APSRAA KQ G
Sbjct:    4 MFADTILIVFISICTALLAEGITWVLVYRTDKYKRLKAEVEKQSKKLEKKKETITES-AGRQQKKKIERQEEKLKNNNRDLSMVRMKSMFAIGFCFTALMGMFNSIFDGRVVAKLPFVPLSYIQGLSHRNLLGEDYTDCSFIFLYILCTMSIRQNIQKMLGLAPSRAATKQAG 175
[Close]
BLAST of Calcium load-activated calcium channel vs. Ensembl Zebrafish
Match: tmco1 (transmembrane and coiled-coil domains 1 [Source:NCBI gene;Acc:378980])

HSP 1 Score: 187.578 bits (475), Expect = 6.944e-58
Identity = 107/160 (66.88%), Postives = 134/160 (83.75%), Query Frame = 2 
Query:   89 FTAFLGEGLTWLLIYRTEKYKRLKTEVDKQSKKLEKQRDDFVETISDKNAXXXXXXXXXXXXNFNRDLSTVKMKSMFVIGLAFTAFVSMFSSIFEGRIVCRLPFTPISFLQGLSHRNLAGDDYTECSFIFLYIICTMSIRQNVQKLLGFAPSRAANKQHG 568
            F +    G+TW+L+YRT+KYKRLK EV+KQSKKLEK+++   E+ + +  KKK+ERQEEKLKN NRDLS V+MKSMF IG  FTA + MF+SIF+GR+V +LPF P+S++QGLSHRNL G+DYT+CSFIFLYI+CTMSIRQN+QK+LG APSRAA KQ G
Sbjct:   13 FVSLCFTGITWVLVYRTDKYKRLKAEVEKQSKKLEKKKETITES-AGRQQKKKIERQEEKLKNNNRDLSMVRMKSMFAIGFCFTALMGMFNSIFDGRVVAKLPFVPLSYIQGLSHRNLLGEDYTDCSFIFLYILCTMSIRQNIQKMLGLAPSRAATKQAG 171
[Close]
BLAST of Calcium load-activated calcium channel vs. Ensembl Zebrafish
Match: tmco1 (transmembrane and coiled-coil domains 1 [Source:NCBI gene;Acc:378980])

HSP 1 Score: 187.578 bits (475), Expect = 6.944e-58
Identity = 107/160 (66.88%), Postives = 134/160 (83.75%), Query Frame = 2 
Query:   89 FTAFLGEGLTWLLIYRTEKYKRLKTEVDKQSKKLEKQRDDFVETISDKNAXXXXXXXXXXXXNFNRDLSTVKMKSMFVIGLAFTAFVSMFSSIFEGRIVCRLPFTPISFLQGLSHRNLAGDDYTECSFIFLYIICTMSIRQNVQKLLGFAPSRAANKQHG 568
            F +    G+TW+L+YRT+KYKRLK EV+KQSKKLEK+++   E+ + +  KKK+ERQEEKLKN NRDLS V+MKSMF IG  FTA + MF+SIF+GR+V +LPF P+S++QGLSHRNL G+DYT+CSFIFLYI+CTMSIRQN+QK+LG APSRAA KQ G
Sbjct:   13 FVSLCFTGITWVLVYRTDKYKRLKAEVEKQSKKLEKKKETITES-AGRQQKKKIERQEEKLKNNNRDLSMVRMKSMFAIGFCFTALMGMFNSIFDGRVVAKLPFVPLSYIQGLSHRNLLGEDYTDCSFIFLYILCTMSIRQNIQKMLGLAPSRAATKQAG 171
[Close]
BLAST of Calcium load-activated calcium channel vs. Ensembl Xenopus
Match: mov10 (Mov10 RISC complex RNA helicase [Source:Xenbase;Acc:XB-GENE-483538])

HSP 1 Score: 209.149 bits (531), Expect = 3.450e-66
Identity = 119/173 (68.79%), Postives = 146/173 (84.39%), Query Frame = 2 
Query:   50 MIQDTLLIVFISFFTAFLGEGLTWLLIYRTEKYKRLKTEVDKQSKKLEKQRDDFVETISDKNAXXXXXXXXXXXXNFNRDLSTVKMKSMFVIGLAFTAFVSMFSSIFEGRIVCRLPFTPISFLQGLSHRNLAGDDYTECSFIFLYIICTMSIRQNVQKLLGFAPSRAANKQHG 568
            M  DT+LIVFIS  TA L EG+TW+L+YRT+KYKRLK EV+KQSKKLEK+++   E+ + +  KKK+ERQEEKLKN NRDLS V+MKSMF IG  FTA + MF+SIF+GR+V +LPF P+S++QGLSHRNL G+DY++CSFIFLYI+CTMSIRQN+QKLLG APSRAA KQ G
Sbjct:    4 MFADTILIVFISVCTALLAEGITWVLVYRTDKYKRLKAEVEKQSKKLEKKKESITES-AGRTQKKKIERQEEKLKNNNRDLSMVRMKSMFAIGFCFTALMGMFNSIFDGRVVAKLPFVPLSYIQGLSHRNLIGEDYSDCSFIFLYILCTMSIRQNIQKLLGLAPSRAATKQAG 175
[Close]
BLAST of Calcium load-activated calcium channel vs. Ensembl Xenopus
Match: mov10 (Mov10 RISC complex RNA helicase [Source:Xenbase;Acc:XB-GENE-483538])

HSP 1 Score: 176.407 bits (446), Expect = 1.569e-53
Identity = 111/173 (64.16%), Postives = 135/173 (78.03%), Query Frame = 2 
Query:   50 MIQDTLLIVFISFFTAFLGEGLTWLLIYRTEKYKRLKTEVDKQSKKLEKQRDDFVETISDKNAXXXXXXXXXXXXNFNRDLSTVKMKSMFVIGLAFTAFVSMFSSIFEGRIVCRLPFTPISFLQGLSHRNLAGDDYTECSFIFLYIICTMSIRQNVQKLLGFAPSRAANKQHG 568
            M  DT+LIVFIS  TA L EG+TW+L+YRT+KYKRLK EV+KQSKKLEK+++   E+ + +  KKK+ERQEEKLKN NRDLS V+MKSMF IG     F S+F  +        LPF P+S++QGLSHRNL G+DY++CSFIFLYI+CTMSIRQN+QKLLG APSRAA KQ G
Sbjct:    4 MFADTILIVFISVCTALLAEGITWVLVYRTDKYKRLKAEVEKQSKKLEKKKESITES-AGRTQKKKIERQEEKLKNNNRDLSMVRMKSMFAIG-----FFSLFFHL------SHLPFVPLSYIQGLSHRNLIGEDYSDCSFIFLYILCTMSIRQNIQKLLGLAPSRAATKQAG 164
[Close]
BLAST of Calcium load-activated calcium channel vs. Ensembl Mouse
Match: Tmco1 (transmembrane and coiled-coil domains 1 [Source:MGI Symbol;Acc:MGI:1921173])

HSP 1 Score: 210.69 bits (535), Expect = 7.297e-67
Identity = 121/173 (69.94%), Postives = 146/173 (84.39%), Query Frame = 2 
Query:   50 MIQDTLLIVFISFFTAFLGEGLTWLLIYRTEKYKRLKTEVDKQSKKLEKQRDDFVETISDKNAXXXXXXXXXXXXNFNRDLSTVKMKSMFVIGLAFTAFVSMFSSIFEGRIVCRLPFTPISFLQGLSHRNLAGDDYTECSFIFLYIICTMSIRQNVQKLLGFAPSRAANKQHG 568
            M  DTLLIVFIS  TA L EG+TW+L+YRT+KYKRLK EV+KQSKKLEK+++   E+ + +  KKK+ERQEEKLKN NRDLS V+MKSMF IG  FTA + MF+SIF+GR+V +LPFTP+S++QGLSHRNL GDD T+CSFIFLYI+CTMSIRQN+QK+LG APSRAA KQ G
Sbjct:    4 MFADTLLIVFISVCTALLAEGITWVLVYRTDKYKRLKAEVEKQSKKLEKKKETITES-AGRQQKKKIERQEEKLKNNNRDLSMVRMKSMFAIGFCFTALMGMFNSIFDGRVVAKLPFTPLSYIQGLSHRNLLGDDTTDCSFIFLYILCTMSIRQNIQKILGLAPSRAATKQAG 175
[Close]
BLAST of Calcium load-activated calcium channel vs. Ensembl Mouse
Match: Tmco1 (transmembrane and coiled-coil domains 1 [Source:MGI Symbol;Acc:MGI:1921173])

HSP 1 Score: 210.69 bits (535), Expect = 7.297e-67
Identity = 121/173 (69.94%), Postives = 146/173 (84.39%), Query Frame = 2 
Query:   50 MIQDTLLIVFISFFTAFLGEGLTWLLIYRTEKYKRLKTEVDKQSKKLEKQRDDFVETISDKNAXXXXXXXXXXXXNFNRDLSTVKMKSMFVIGLAFTAFVSMFSSIFEGRIVCRLPFTPISFLQGLSHRNLAGDDYTECSFIFLYIICTMSIRQNVQKLLGFAPSRAANKQHG 568
            M  DTLLIVFIS  TA L EG+TW+L+YRT+KYKRLK EV+KQSKKLEK+++   E+ + +  KKK+ERQEEKLKN NRDLS V+MKSMF IG  FTA + MF+SIF+GR+V +LPFTP+S++QGLSHRNL GDD T+CSFIFLYI+CTMSIRQN+QK+LG APSRAA KQ G
Sbjct:    4 MFADTLLIVFISVCTALLAEGITWVLVYRTDKYKRLKAEVEKQSKKLEKKKETITES-AGRQQKKKIERQEEKLKNNNRDLSMVRMKSMFAIGFCFTALMGMFNSIFDGRVVAKLPFTPLSYIQGLSHRNLLGDDTTDCSFIFLYILCTMSIRQNIQKILGLAPSRAATKQAG 175
[Close]
BLAST of Calcium load-activated calcium channel vs. Ensembl Mouse
Match: Tmco1 (transmembrane and coiled-coil domains 1 [Source:MGI Symbol;Acc:MGI:1921173])

HSP 1 Score: 189.119 bits (479), Expect = 2.343e-58
Identity = 108/154 (70.13%), Postives = 133/154 (86.36%), Query Frame = 2 
Query:  107 EGLTWLLIYRTEKYKRLKTEVDKQSKKLEKQRDDFVETISDKNAXXXXXXXXXXXXNFNRDLSTVKMKSMFVIGLAFTAFVSMFSSIFEGRIVCRLPFTPISFLQGLSHRNLAGDDYTECSFIFLYIICTMSIRQNVQKLLGFAPSRAANKQHG 568
            EG+TW+L+YRT+KYKRLK EV+KQSKKLEK+++   E+ + +  KKK+ERQEEKLKN NRDLS V+MKSMF IG  FTA + MF+SIF+GR+V +LPFTP+S++QGLSHRNL GDD T+CSFIFLYI+CTMSIRQN+QK+LG APSRAA KQ G
Sbjct:   35 EGITWVLVYRTDKYKRLKAEVEKQSKKLEKKKETITES-AGRQQKKKIERQEEKLKNNNRDLSMVRMKSMFAIGFCFTALMGMFNSIFDGRVVAKLPFTPLSYIQGLSHRNLLGDDTTDCSFIFLYILCTMSIRQNIQKILGLAPSRAATKQAG 187
[Close]
BLAST of Calcium load-activated calcium channel vs. UniProt/SwissProt
Match: sp|Q5I0H4|TMCO1_RAT (Calcium load-activated calcium channel OS=Rattus norvegicus OX=10116 GN=Tmco1 PE=2 SV=1)

HSP 1 Score: 210.69 bits (535), Expect = 5.104e-66
Identity = 121/173 (69.94%), Postives = 146/173 (84.39%), Query Frame = 2 
Query:   50 MIQDTLLIVFISFFTAFLGEGLTWLLIYRTEKYKRLKTEVDKQSKKLEKQRDDFVETISDKNAXXXXXXXXXXXXNFNRDLSTVKMKSMFVIGLAFTAFVSMFSSIFEGRIVCRLPFTPISFLQGLSHRNLAGDDYTECSFIFLYIICTMSIRQNVQKLLGFAPSRAANKQHG 568
            M  DTLLIVFIS  TA L EG+TW+L+YRT+KYKRLK EV+KQSKKLEK+++   E+ + +  KKK+ERQEEKLKN NRDLS V+MKSMF IG  FTA + MF+SIF+GR+V +LPFTP+S++QGLSHRNL GDD T+CSFIFLYI+CTMSIRQN+QK+LG APSRAA KQ G
Sbjct:    4 MFADTLLIVFISVCTALLAEGITWVLVYRTDKYKRLKAEVEKQSKKLEKKKETITES-AGRQQKKKIERQEEKLKNNNRDLSMVRMKSMFAIGFCFTALMGMFNSIFDGRVVAKLPFTPLSYIQGLSHRNLLGDDTTDCSFIFLYILCTMSIRQNIQKILGLAPSRAATKQAG 175
[Close]
BLAST of Calcium load-activated calcium channel vs. UniProt/SwissProt
Match: sp|Q5R9B0|TMCO1_PONAB (Calcium load-activated calcium channel OS=Pongo abelii OX=9601 GN=TMCO1 PE=2 SV=1)

HSP 1 Score: 210.69 bits (535), Expect = 5.104e-66
Identity = 121/173 (69.94%), Postives = 146/173 (84.39%), Query Frame = 2 
Query:   50 MIQDTLLIVFISFFTAFLGEGLTWLLIYRTEKYKRLKTEVDKQSKKLEKQRDDFVETISDKNAXXXXXXXXXXXXNFNRDLSTVKMKSMFVIGLAFTAFVSMFSSIFEGRIVCRLPFTPISFLQGLSHRNLAGDDYTECSFIFLYIICTMSIRQNVQKLLGFAPSRAANKQHG 568
            M  DTLLIVFIS  TA L EG+TW+L+YRT+KYKRLK EV+KQSKKLEK+++   E+ + +  KKK+ERQEEKLKN NRDLS V+MKSMF IG  FTA + MF+SIF+GR+V +LPFTP+S++QGLSHRNL GDD T+CSFIFLYI+CTMSIRQN+QK+LG APSRAA KQ G
Sbjct:    4 MFADTLLIVFISVCTALLAEGITWVLVYRTDKYKRLKAEVEKQSKKLEKKKETITES-AGRQQKKKIERQEEKLKNNNRDLSMVRMKSMFAIGFCFTALMGMFNSIFDGRVVAKLPFTPLSYIQGLSHRNLLGDDTTDCSFIFLYILCTMSIRQNIQKILGLAPSRAATKQAG 175
[Close]
BLAST of Calcium load-activated calcium channel vs. UniProt/SwissProt
Match: sp|C5HGF3|TMCO1_PIG (Calcium load-activated calcium channel OS=Sus scrofa OX=9823 GN=TMCO1 PE=2 SV=1)

HSP 1 Score: 210.69 bits (535), Expect = 5.104e-66
Identity = 121/173 (69.94%), Postives = 146/173 (84.39%), Query Frame = 2 
Query:   50 MIQDTLLIVFISFFTAFLGEGLTWLLIYRTEKYKRLKTEVDKQSKKLEKQRDDFVETISDKNAXXXXXXXXXXXXNFNRDLSTVKMKSMFVIGLAFTAFVSMFSSIFEGRIVCRLPFTPISFLQGLSHRNLAGDDYTECSFIFLYIICTMSIRQNVQKLLGFAPSRAANKQHG 568
            M  DTLLIVFIS  TA L EG+TW+L+YRT+KYKRLK EV+KQSKKLEK+++   E+ + +  KKK+ERQEEKLKN NRDLS V+MKSMF IG  FTA + MF+SIF+GR+V +LPFTP+S++QGLSHRNL GDD T+CSFIFLYI+CTMSIRQN+QK+LG APSRAA KQ G
Sbjct:    4 MFADTLLIVFISVCTALLAEGITWVLVYRTDKYKRLKAEVEKQSKKLEKKKETITES-AGRQQKKKIERQEEKLKNNNRDLSMVRMKSMFAIGFCFTALMGMFNSIFDGRVVAKLPFTPLSYIQGLSHRNLLGDDTTDCSFIFLYILCTMSIRQNIQKILGLAPSRAATKQAG 175
[Close]
BLAST of Calcium load-activated calcium channel vs. UniProt/SwissProt
Match: sp|Q921L3|TMCO1_MOUSE (Calcium load-activated calcium channel OS=Mus musculus OX=10090 GN=Tmco1 PE=1 SV=1)

HSP 1 Score: 210.69 bits (535), Expect = 5.104e-66
Identity = 121/173 (69.94%), Postives = 146/173 (84.39%), Query Frame = 2 
Query:   50 MIQDTLLIVFISFFTAFLGEGLTWLLIYRTEKYKRLKTEVDKQSKKLEKQRDDFVETISDKNAXXXXXXXXXXXXNFNRDLSTVKMKSMFVIGLAFTAFVSMFSSIFEGRIVCRLPFTPISFLQGLSHRNLAGDDYTECSFIFLYIICTMSIRQNVQKLLGFAPSRAANKQHG 568
            M  DTLLIVFIS  TA L EG+TW+L+YRT+KYKRLK EV+KQSKKLEK+++   E+ + +  KKK+ERQEEKLKN NRDLS V+MKSMF IG  FTA + MF+SIF+GR+V +LPFTP+S++QGLSHRNL GDD T+CSFIFLYI+CTMSIRQN+QK+LG APSRAA KQ G
Sbjct:    4 MFADTLLIVFISVCTALLAEGITWVLVYRTDKYKRLKAEVEKQSKKLEKKKETITES-AGRQQKKKIERQEEKLKNNNRDLSMVRMKSMFAIGFCFTALMGMFNSIFDGRVVAKLPFTPLSYIQGLSHRNLLGDDTTDCSFIFLYILCTMSIRQNIQKILGLAPSRAATKQAG 175
[Close]
BLAST of Calcium load-activated calcium channel vs. UniProt/SwissProt
Match: sp|Q3T0N3|TMCO1_BOVIN (Calcium load-activated calcium channel OS=Bos taurus OX=9913 GN=TMCO1 PE=2 SV=1)

HSP 1 Score: 210.69 bits (535), Expect = 5.104e-66
Identity = 121/173 (69.94%), Postives = 146/173 (84.39%), Query Frame = 2 
Query:   50 MIQDTLLIVFISFFTAFLGEGLTWLLIYRTEKYKRLKTEVDKQSKKLEKQRDDFVETISDKNAXXXXXXXXXXXXNFNRDLSTVKMKSMFVIGLAFTAFVSMFSSIFEGRIVCRLPFTPISFLQGLSHRNLAGDDYTECSFIFLYIICTMSIRQNVQKLLGFAPSRAANKQHG 568
            M  DTLLIVFIS  TA L EG+TW+L+YRT+KYKRLK EV+KQSKKLEK+++   E+ + +  KKK+ERQEEKLKN NRDLS V+MKSMF IG  FTA + MF+SIF+GR+V +LPFTP+S++QGLSHRNL GDD T+CSFIFLYI+CTMSIRQN+QK+LG APSRAA KQ G
Sbjct:    4 MFADTLLIVFISVCTALLAEGITWVLVYRTDKYKRLKAEVEKQSKKLEKKKETITES-AGRQQKKKIERQEEKLKNNNRDLSMVRMKSMFAIGFCFTALMGMFNSIFDGRVVAKLPFTPLSYIQGLSHRNLLGDDTTDCSFIFLYILCTMSIRQNIQKILGLAPSRAATKQAG 175
[Close]
BLAST of Calcium load-activated calcium channel vs. TrEMBL
Match: A0A182K3Q2 (Calcium load-activated calcium channel OS=Anopheles christyi OX=43041 PE=3 SV=1)

HSP 1 Score: 256.529 bits (654), Expect = 1.438e-81
Identity = 133/173 (76.88%), Postives = 153/173 (88.44%), Query Frame = 2 
Query:   50 MIQDTLLIVFISFFTAFLGEGLTWLLIYRTEKYKRLKTEVDKQSKKLEKQRDDFVETISDKNAXXXXXXXXXXXXNFNRDLSTVKMKSMFVIGLAFTAFVSMFSSIFEGRIVCRLPFTPISFLQGLSHRNLAGDDYTECSFIFLYIICTMSIRQNVQKLLGFAPSRAANKQHG 568
            M  DTLLIVFIS FTA LGEGLTW+++YRTEKY++LK EV+KQSKKLEK+++   E++ DKN KKK+ER EEKLKN NRDLS VKMKSMF IG AFTA +SMF+SIF+GRIV RLPF PIS++QGLSHRNL GDDYTECSFIFLYI+CTMSIRQN+QK+LGFAPSRAANKQ G
Sbjct:    1 MWADTLLIVFISIFTALLGEGLTWVMVYRTEKYQKLKGEVEKQSKKLEKRKETLGESL-DKNHKKKIERDEEKLKNNNRDLSLVKMKSMFAIGFAFTALLSMFNSIFDGRIVARLPFVPISWIQGLSHRNLPGDDYTECSFIFLYILCTMSIRQNIQKMLGFAPSRAANKQAG 172
[Close]
BLAST of Calcium load-activated calcium channel vs. TrEMBL
Match: A0A1S4H037 (Calcium load-activated calcium channel OS=Anopheles gambiae OX=7165 PE=3 SV=1)

HSP 1 Score: 254.603 bits (649), Expect = 9.028e-81
Identity = 132/173 (76.30%), Postives = 153/173 (88.44%), Query Frame = 2 
Query:   50 MIQDTLLIVFISFFTAFLGEGLTWLLIYRTEKYKRLKTEVDKQSKKLEKQRDDFVETISDKNAXXXXXXXXXXXXNFNRDLSTVKMKSMFVIGLAFTAFVSMFSSIFEGRIVCRLPFTPISFLQGLSHRNLAGDDYTECSFIFLYIICTMSIRQNVQKLLGFAPSRAANKQHG 568
            M  DTLLIVFIS FTA LGEGLTW+++YRTEKY++LK EV+KQSKKLEK+++   E++ DKN KKK+ER EEKLKN NRDLS VKMKSMF IG AFTA +SMF+SIF+GRIV RLPF PIS++QGLSHRNL GDDYTECSFIFLYI+CTMSIRQN+QK+LGFAPSRAA+KQ G
Sbjct:    1 MWADTLLIVFISIFTALLGEGLTWVMVYRTEKYQKLKGEVEKQSKKLEKRKETLGESL-DKNHKKKIERDEEKLKNNNRDLSLVKMKSMFAIGFAFTALLSMFNSIFDGRIVARLPFVPISWIQGLSHRNLPGDDYTECSFIFLYILCTMSIRQNIQKMLGFAPSRAASKQAG 172
[Close]
BLAST of Calcium load-activated calcium channel vs. TrEMBL
Match: A0A182U5Y7 (Calcium load-activated calcium channel OS=Anopheles melas OX=34690 PE=3 SV=1)

HSP 1 Score: 254.603 bits (649), Expect = 9.028e-81
Identity = 132/173 (76.30%), Postives = 153/173 (88.44%), Query Frame = 2 
Query:   50 MIQDTLLIVFISFFTAFLGEGLTWLLIYRTEKYKRLKTEVDKQSKKLEKQRDDFVETISDKNAXXXXXXXXXXXXNFNRDLSTVKMKSMFVIGLAFTAFVSMFSSIFEGRIVCRLPFTPISFLQGLSHRNLAGDDYTECSFIFLYIICTMSIRQNVQKLLGFAPSRAANKQHG 568
            M  DTLLIVFIS FTA LGEGLTW+++YRTEKY++LK EV+KQSKKLEK+++   E++ DKN KKK+ER EEKLKN NRDLS VKMKSMF IG AFTA +SMF+SIF+GRIV RLPF PIS++QGLSHRNL GDDYTECSFIFLYI+CTMSIRQN+QK+LGFAPSRAA+KQ G
Sbjct:    1 MWADTLLIVFISIFTALLGEGLTWVMVYRTEKYQKLKGEVEKQSKKLEKRKETLGESL-DKNHKKKIERDEEKLKNNNRDLSLVKMKSMFAIGFAFTALLSMFNSIFDGRIVARLPFVPISWIQGLSHRNLPGDDYTECSFIFLYILCTMSIRQNIQKMLGFAPSRAASKQAG 172
[Close]
BLAST of Calcium load-activated calcium channel vs. TrEMBL
Match: A0A182X2Y3 (Calcium load-activated calcium channel OS=Anopheles quadriannulatus OX=34691 PE=3 SV=1)

HSP 1 Score: 254.603 bits (649), Expect = 9.028e-81
Identity = 132/173 (76.30%), Postives = 153/173 (88.44%), Query Frame = 2 
Query:   50 MIQDTLLIVFISFFTAFLGEGLTWLLIYRTEKYKRLKTEVDKQSKKLEKQRDDFVETISDKNAXXXXXXXXXXXXNFNRDLSTVKMKSMFVIGLAFTAFVSMFSSIFEGRIVCRLPFTPISFLQGLSHRNLAGDDYTECSFIFLYIICTMSIRQNVQKLLGFAPSRAANKQHG 568
            M  DTLLIVFIS FTA LGEGLTW+++YRTEKY++LK EV+KQSKKLEK+++   E++ DKN KKK+ER EEKLKN NRDLS VKMKSMF IG AFTA +SMF+SIF+GRIV RLPF PIS++QGLSHRNL GDDYTECSFIFLYI+CTMSIRQN+QK+LGFAPSRAA+KQ G
Sbjct:    1 MWADTLLIVFISIFTALLGEGLTWVMVYRTEKYQKLKGEVEKQSKKLEKRKETLGESL-DKNHKKKIERDEEKLKNNNRDLSLVKMKSMFAIGFAFTALLSMFNSIFDGRIVARLPFVPISWIQGLSHRNLPGDDYTECSFIFLYILCTMSIRQNIQKMLGFAPSRAASKQAG 172
[Close]
BLAST of Calcium load-activated calcium channel vs. TrEMBL
Match: A0A182I4X1 (Calcium load-activated calcium channel OS=Anopheles arabiensis OX=7173 PE=3 SV=1)

HSP 1 Score: 254.603 bits (649), Expect = 9.028e-81
Identity = 132/173 (76.30%), Postives = 153/173 (88.44%), Query Frame = 2 
Query:   50 MIQDTLLIVFISFFTAFLGEGLTWLLIYRTEKYKRLKTEVDKQSKKLEKQRDDFVETISDKNAXXXXXXXXXXXXNFNRDLSTVKMKSMFVIGLAFTAFVSMFSSIFEGRIVCRLPFTPISFLQGLSHRNLAGDDYTECSFIFLYIICTMSIRQNVQKLLGFAPSRAANKQHG 568
            M  DTLLIVFIS FTA LGEGLTW+++YRTEKY++LK EV+KQSKKLEK+++   E++ DKN KKK+ER EEKLKN NRDLS VKMKSMF IG AFTA +SMF+SIF+GRIV RLPF PIS++QGLSHRNL GDDYTECSFIFLYI+CTMSIRQN+QK+LGFAPSRAA+KQ G
Sbjct:    1 MWADTLLIVFISIFTALLGEGLTWVMVYRTEKYQKLKGEVEKQSKKLEKRKETLGESL-DKNHKKKIERDEEKLKNNNRDLSLVKMKSMFAIGFAFTALLSMFNSIFDGRIVARLPFVPISWIQGLSHRNLPGDDYTECSFIFLYILCTMSIRQNIQKMLGFAPSRAASKQAG 172
[Close]
BLAST of Calcium load-activated calcium channel vs. Ensembl Nematostella
Match: EDO47188 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7RN03])

HSP 1 Score: 221.476 bits (563), Expect = 1.092e-71
Identity = 112/173 (64.74%), Postives = 141/173 (81.50%), Query Frame = 2 
Query:   50 MIQDTLLIVFISFFTAFLGEGLTWLLIYRTEKYKRLKTEVDKQSKKLEKQRDDFVETISDKNAXXXXXXXXXXXXNFNRDLSTVKMKSMFVIGLAFTAFVSMFSSIFEGRIVCRLPFTPISFLQGLSHRNLAGDDYTECSFIFLYIICTMSIRQNVQKLLGFAPSRAANKQHG 568
            M  D+LLI+FIS  TA L EG+T++L+YRT+KYK+LK EV+K SKKLE+++++  +       KKK+ER EEKLKN NRDLS VKMKS+F IG  FTA + MF+SIF+GR+V +LPF P S++QGLSHRNL GDD+TECSFIFLYI+CTM++RQNVQK LGFAPSRAA+K  G
Sbjct:    1 MFADSLLILFISLATALLSEGITYILVYRTDKYKKLKAEVEKDSKKLERRKENLTDAPRQGGQKKKIERVEEKLKNHNRDLSMVKMKSIFAIGFTFTALIGMFNSIFDGRVVAKLPFEPHSWIQGLSHRNLMGDDFTECSFIFLYILCTMAVRQNVQKALGFAPSRAASKVGG 173
[Close]
BLAST of Calcium load-activated calcium channel vs. Ensembl Medaka
Match: tmco1 (transmembrane and coiled-coil domains 1 [Source:NCBI gene;Acc:111947389])

HSP 1 Score: 211.846 bits (538), Expect = 2.017e-67
Identity = 120/173 (69.36%), Postives = 146/173 (84.39%), Query Frame = 2 
Query:   50 MIQDTLLIVFISFFTAFLGEGLTWLLIYRTEKYKRLKTEVDKQSKKLEKQRDDFVETISDKNAXXXXXXXXXXXXNFNRDLSTVKMKSMFVIGLAFTAFVSMFSSIFEGRIVCRLPFTPISFLQGLSHRNLAGDDYTECSFIFLYIICTMSIRQNVQKLLGFAPSRAANKQHG 568
            M  DT+LIVFIS  TA L EG+TW+L+YRTEKYKRLK EV+KQSKKLEK+++   E+ + +  KKK+ERQEEKLKN NRDLS V+MKSMF IG  FTA + MF+SIF+GR+V +LPF P+S++QGLSHRNL G+DYT+CSFIFLYI+CTMSIRQN+QK+LG APSRAA KQ G
Sbjct:    4 MFADTILIVFISVCTALLAEGITWVLVYRTEKYKRLKAEVEKQSKKLEKKKETITES-AGRQQKKKIERQEEKLKNNNRDLSMVRMKSMFAIGFCFTALMGMFNSIFDGRVVAKLPFVPLSYIQGLSHRNLLGEDYTDCSFIFLYILCTMSIRQNIQKMLGLAPSRAATKQAG 175
[Close]
BLAST of Calcium load-activated calcium channel vs. Ensembl Medaka
Match: tmco1 (transmembrane and coiled-coil domains 1 [Source:NCBI gene;Acc:111947389])

HSP 1 Score: 199.134 bits (505), Expect = 3.184e-62
Identity = 120/194 (61.86%), Postives = 146/194 (75.26%), Query Frame = 2 
Query:   50 MIQDTLLIVFISFFTAFLGE---------------------GLTWLLIYRTEKYKRLKTEVDKQSKKLEKQRDDFVETISDKNAXXXXXXXXXXXXNFNRDLSTVKMKSMFVIGLAFTAFVSMFSSIFEGRIVCRLPFTPISFLQGLSHRNLAGDDYTECSFIFLYIICTMSIRQNVQKLLGFAPSRAANKQHG 568
            M  DT+LIVFIS  TA L E                     G+TW+L+YRTEKYKRLK EV+KQSKKLEK+++   E+ + +  KKK+ERQEEKLKN NRDLS V+MKSMF IG  FTA + MF+SIF+GR+V +LPF P+S++QGLSHRNL G+DYT+CSFIFLYI+CTMSIRQN+QK+LG APSRAA KQ G
Sbjct:    4 MFADTILIVFISVCTALLAEDEEKRKREKRRIRRVCKQIDDGITWVLVYRTEKYKRLKAEVEKQSKKLEKKKETITES-AGRQQKKKIERQEEKLKNNNRDLSMVRMKSMFAIGFCFTALMGMFNSIFDGRVVAKLPFVPLSYIQGLSHRNLLGEDYTDCSFIFLYILCTMSIRQNIQKMLGLAPSRAATKQAG 196
[Close]
BLAST of Calcium load-activated calcium channel vs. Planmine SMEST
Match: SMESG000016852.1 (SMESG000016852.1)

HSP 1 Score: 329.717 bits (844), Expect = 6.973e-114
Identity = 173/173 (100.00%), Postives = 173/173 (100.00%), Query Frame = 2 
Query:   50 MIQDTLLIVFISFFTAFLGEGLTWLLIYRTEKYKRLKTEVDKQSKKLEKQRDDFVETISDKNAXXXXXXXXXXXXNFNRDLSTVKMKSMFVIGLAFTAFVSMFSSIFEGRIVCRLPFTPISFLQGLSHRNLAGDDYTECSFIFLYIICTMSIRQNVQKLLGFAPSRAANKQHG 568
            MIQDTLLIVFISFFTAFLGEGLTWLLIYRTEKYKRLKTEVDKQSKKLEKQRDDFVETISDKNAKKKLERQEEKLKNFNRDLSTVKMKSMFVIGLAFTAFVSMFSSIFEGRIVCRLPFTPISFLQGLSHRNLAGDDYTECSFIFLYIICTMSIRQNVQKLLGFAPSRAANKQHG
Sbjct:    1 MIQDTLLIVFISFFTAFLGEGLTWLLIYRTEKYKRLKTEVDKQSKKLEKQRDDFVETISDKNAKKKLERQEEKLKNFNRDLSTVKMKSMFVIGLAFTAFVSMFSSIFEGRIVCRLPFTPISFLQGLSHRNLAGDDYTECSFIFLYIICTMSIRQNVQKLLGFAPSRAANKQHG 173
The following BLAST results are available for this feature:
BLAST of Calcium load-activated calcium channel vs. Ensembl Human
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Human e!99)
Total hits: 5
Match NameE-valueIdentityDescription
TMCO11.063e-6669.94transmembrane and coiled-coil domains 1 [Source:HG... [more]
TMCO19.129e-6669.94transmembrane and coiled-coil domains 1 [Source:HG... [more]
TMCO19.129e-6669.94transmembrane and coiled-coil domains 1 [Source:HG... [more]
TMCO12.394e-4568.38transmembrane and coiled-coil domains 1 [Source:HG... [more]
TMCO15.465e-4473.33transmembrane and coiled-coil domains 1 [Source:HG... [more]
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BLAST of Calcium load-activated calcium channel vs. Ensembl Celegans
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99)
Total hits: 1
Match NameE-valueIdentityDescription
F22B5.102.042e-6364.53Calcium load-activated calcium channel homolog [S... [more]
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BLAST of Calcium load-activated calcium channel vs. Ensembl Fly
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99)
Total hits: 1
Match NameE-valueIdentityDescription
CG104702.764e-7973.10gene:FBgn0032746 transcript:FBtr0081146[more]
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BLAST of Calcium load-activated calcium channel vs. Ensembl Zebrafish
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99)
Total hits: 3
Match NameE-valueIdentityDescription
tmco19.251e-6768.79transmembrane and coiled-coil domains 1 [Source:NC... [more]
tmco16.944e-5866.88transmembrane and coiled-coil domains 1 [Source:NC... [more]
tmco16.944e-5866.88transmembrane and coiled-coil domains 1 [Source:NC... [more]
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BLAST of Calcium load-activated calcium channel vs. Ensembl Xenopus
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99)
Total hits: 2
Match NameE-valueIdentityDescription
mov103.450e-6668.79Mov10 RISC complex RNA helicase [Source:Xenbase;Ac... [more]
mov101.569e-5364.16Mov10 RISC complex RNA helicase [Source:Xenbase;Ac... [more]
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BLAST of Calcium load-activated calcium channel vs. Ensembl Mouse
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99)
Total hits: 3
Match NameE-valueIdentityDescription
Tmco17.297e-6769.94transmembrane and coiled-coil domains 1 [Source:MG... [more]
Tmco17.297e-6769.94transmembrane and coiled-coil domains 1 [Source:MG... [more]
Tmco12.343e-5870.13transmembrane and coiled-coil domains 1 [Source:MG... [more]
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BLAST of Calcium load-activated calcium channel vs. UniProt/SwissProt
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt)
Total hits: 5
Match NameE-valueIdentityDescription
sp|Q5I0H4|TMCO1_RAT5.104e-6669.94Calcium load-activated calcium channel OS=Rattus n... [more]
sp|Q5R9B0|TMCO1_PONAB5.104e-6669.94Calcium load-activated calcium channel OS=Pongo ab... [more]
sp|C5HGF3|TMCO1_PIG5.104e-6669.94Calcium load-activated calcium channel OS=Sus scro... [more]
sp|Q921L3|TMCO1_MOUSE5.104e-6669.94Calcium load-activated calcium channel OS=Mus musc... [more]
sp|Q3T0N3|TMCO1_BOVIN5.104e-6669.94Calcium load-activated calcium channel OS=Bos taur... [more]
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BLAST of Calcium load-activated calcium channel vs. TrEMBL
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL)
Total hits: 5
Match NameE-valueIdentityDescription
A0A182K3Q21.438e-8176.88Calcium load-activated calcium channel OS=Anophele... [more]
A0A1S4H0379.028e-8176.30Calcium load-activated calcium channel OS=Anophele... [more]
A0A182U5Y79.028e-8176.30Calcium load-activated calcium channel OS=Anophele... [more]
A0A182X2Y39.028e-8176.30Calcium load-activated calcium channel OS=Anophele... [more]
A0A182I4X19.028e-8176.30Calcium load-activated calcium channel OS=Anophele... [more]
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BLAST of Calcium load-activated calcium channel vs. Ensembl Cavefish
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99)
Total hits: 0
Match NameE-valueIdentityDescription
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BLAST of Calcium load-activated calcium channel vs. Ensembl Sea Lamprey
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99)
Total hits: 0
Match NameE-valueIdentityDescription
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BLAST of Calcium load-activated calcium channel vs. Ensembl Yeast
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46)
Total hits: 0
Match NameE-valueIdentityDescription
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BLAST of Calcium load-activated calcium channel vs. Ensembl Nematostella
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46)
Total hits: 1
Match NameE-valueIdentityDescription
EDO471881.092e-7164.74Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7... [more]
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BLAST of Calcium load-activated calcium channel vs. Ensembl Medaka
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99)
Total hits: 2
Match NameE-valueIdentityDescription
tmco12.017e-6769.36transmembrane and coiled-coil domains 1 [Source:NC... [more]
tmco13.184e-6261.86transmembrane and coiled-coil domains 1 [Source:NC... [more]
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BLAST of Calcium load-activated calcium channel vs. Planmine SMEST
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST)
Total hits: 1
Match NameE-valueIdentityDescription
SMESG000016852.16.973e-114100.00SMESG000016852.1[more]
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Sequences
The following sequences are available for this feature:

transcript sequence

>SMED30010877 ID=SMED30010877|Name=Calcium load-activated calcium channel|organism=Schmidtea mediterranea sexual|type=transcript|length=1126bp
CCGGGATTGTTTTAATAACCACACATATACAGTGAAAAATTCTTTTTAAA
TGATTCAAGATACGCTTTTAATAGTTTTTATATCATTTTTCACAGCATTT
TTGGGCGAAGGTCTTACATGGCTTTTAATTTATCGTACTGAAAAGTATAA
AAGACTGAAAACCGAAGTTGATAAACAAAGCAAAAAATTGGAAAAACAAC
GAGATGATTTCGTTGAGACGATATCAGATAAAAACGCAAAGAAGAAATTG
GAAAGACAAGAAGAAAAGTTAAAAAATTTTAATCGAGATTTGTCAACAGT
TAAAATGAAATCGATGTTTGTGATCGGTTTAGCGTTTACTGCGTTTGTAA
GCATGTTTAGCAGCATTTTCGAAGGCCGGATAGTTTGTCGATTGCCATTT
ACTCCAATTTCGTTTTTGCAAGGATTATCTCACAGAAACCTCGCCGGAGA
TGATTATACAGAATGCTCATTTATTTTCCTCTACATAATTTGCACTATGT
CTATCAGACAGAATGTTCAAAAGCTTTTGGGATTCGCGCCGTCACGAGCA
GCGAATAAACAACACGGATTTTTCTCCCAGAATCAACAATCTTCATTTTT
CAAGCAGTAATCCATCAATAAAATAATTTTATTCAATTTTGCACATAGAA
AATTGTCTTTTTTTCTTGATTTTCCTCGTTAATATTTTGGCTGATTTTGA
TTGGTTTAAACTGAATGTTTAAAGATTTTTATTGATTTTACAATACTTGT
TTTTTATGTTGGTAAGTCTATATCGGGAATTTTGAAATTTAATTTAACTA
AAATTTCAACCAATCACAGCACGATAAAACCTGTCAGTAATTTGGCTGTG
AATTTTTAGATGCCTAGATTTGATTTTTATTGATTTTCTGTCAGTAACGA
GATGTTGCCGATTGTTAAGGAATTGGATATCGCCAATGGTTACTGCCACT
TCGGATTTATGAGCTTGGAATTCAGATTCAGAAGTTAATTTACTAAAGAA
CTGTTTCTAGAGCAGATCATGGAATAAGTTGTGTGTGACAAAATGTTTTG
TTATATGACGTTTTAATCTATGGGCGAAAGTAAATATTATGGCTATGGTA
AAAATTTAAATTAAAAGATTGGCAGG
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protein sequence of SMED30010877-orf-1

>SMED30010877-orf-1 ID=SMED30010877-orf-1|Name=SMED30010877-orf-1|organism=Schmidtea mediterranea sexual|type=polypeptide|length=187bp
MIQDTLLIVFISFFTAFLGEGLTWLLIYRTEKYKRLKTEVDKQSKKLEKQ
RDDFVETISDKNAKKKLERQEEKLKNFNRDLSTVKMKSMFVIGLAFTAFV
SMFSSIFEGRIVCRLPFTPISFLQGLSHRNLAGDDYTECSFIFLYIICTM
SIRQNVQKLLGFAPSRAANKQHGFFSQNQQSSFFKQ*
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Annotated Terms
The following terms have been associated with this transcript:
Vocabulary: Planarian Anatomy
TermDefinition
PLANA:0000101muscle cell
PLANA:0000142posterior region of the whole animal
Vocabulary: INTERPRO
TermDefinition
IPR002809EMC3/TMCO1
IPR008559TMCO1
Vocabulary: cellular component
TermDefinition
GO:0016020membrane
GO:0000139Golgi membrane
GO:0005575cellular_component
GO:0005783endoplasmic reticulum
GO:0005789endoplasmic reticulum membrane
GO:0005794Golgi apparatus
GO:0016021integral component of membrane
GO:0030176integral component of endoplasmic reticulum membrane
Vocabulary: molecular function
TermDefinition
GO:0003674molecular_function
GO:0005262calcium channel activity
Vocabulary: biological process
TermDefinition
GO:0006810transport
GO:0006811ion transport
GO:0006816calcium ion transport
GO:0006983ER overload response
GO:0008150biological_process
GO:0032469endoplasmic reticulum calcium ion homeostasis
GO:0070588calcium ion transmembrane transport
InterPro
Analysis Name: Schmidtea mediteranean smed_20140614 Interproscan
Date Performed: 2020-05-01
IPR TermIPR DescriptionSourceSource TermSource DescriptionAlignment
NoneNo IPR availableCOILSCoilCoilcoord: 33..53
NoneNo IPR availableCOILSCoilCoilcoord: 60..87
NoneNo IPR availableTMHMMTMhelixcoord: 88..107
NoneNo IPR availableTMHMMTMhelixcoord: 5..27
IPR002809Integral membrane protein EMC3/TMCO1-likeSMARTSM01415DUF106_2coord: 4..164
e-value: 1.6E-46
score: 170.6
IPR002809Integral membrane protein EMC3/TMCO1-likePFAMPF01956EMC3_TMCO1coord: 6..163
e-value: 5.1E-38
score: 130.5
IPR008559Calcium load-activated calcium channelPIRSFPIRSF023322UCP023322_TM_coiled-coilcoord: 1..183
e-value: 1.5E-79
score: 263.7
IPR008559Calcium load-activated calcium channelPANTHERPTHR20917PNAS-RELATEDcoord: 1..180