Bestrophin homolog

Overview
NameBestrophin homolog
Smed IDSMED30010746
Length (bp)1360
Neoblast Clusters

Zeng et. al., 2018



▻ Overview

▻ Neoblast Population

▻ Sub-lethal Irradiated Surviving X1 and X2 Cell Population

 

 

Overview

 

Single cell RNA-seq of pluripotent neoblasts and its early progenies


We isolated X1 neoblasts cells enriched in high piwi-1 expression (Neoblast Population), and profiled ∼7,614 individual cells via scRNA-seq. Unsupervised analyses uncovered 12 distinct classes from 7,088 high-quality cells. We designated these classes Nb1 to Nb12 and ordered them based on high (Nb1) to low (Nb12) piwi-1 expression levels. We further defined groups of genes that best classified the cells parsed into 12 distinct cell clusters to generate a scaled expression heat map of discriminative gene sets for each cluster. Expression of each cluster’s gene signatures was validated using multiplex fluorescence in situ hybridization (FISH) co-stained with piwi-1 and largely confirmed the cell clusters revealed by scRNA-seq.

We also tested sub-lethal irradiation exposure. To profile rare pluripotent stem cells (PSCs) and avoid interference from immediate progenitor cells, we determined a time point after sub-lethal irradiation (7 DPI) with minimal piwi-1+ cells, followed by isolation and single-cell RNA-seq of 1,200 individual cells derived from X1 (Piwi-1 high) and X2 (Piwi-1 low) cell populations (Sub-lethal Irradiated Surviving X1 and X2 Cell Population)



Explore this single cell expression dataset with our NB Cluster Shiny App



 

Neoblast Population

 

t-SNE plot shows two-dimensional representation of global gene expression relationships among all neoblasts (n = 7,088 after filter). Cluster identity was assigned based on the top 10 marker genes of each cluster (Table S2), followed by inspection of RNA in situ hybridization patterns. Neoblast groups, Nb.


Expression of Bestrophin homolog (SMED30010746) t-SNE clustered cells

Violin plots show distribution of expression levels for Bestrophin homolog (SMED30010746) in cells (dots) of each of the 12 neoblast clusters.

 

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Sub-lethal Irradiated Surviving X1 and X2 Cell Population

 

t-SNE plot of surviving X1 and X2 cells (n = 1,039 after QC filter) after sub-lethal irradiation. Colors indicate unbiased cell classification via graph-based clustering. SL, sub-lethal irradiated cell groups.

Expression of Bestrophin homolog (SMED30010746) in the t-SNE clustered sub-lethally irradiated X1 and X2 cells.

Violin plots show distribution of expression levels for Bestrophin homolog (SMED30010746) in cells (dots) of each of the 10 clusters of sub-leathally irradiated X1 and X2 cells.

 

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Embryonic Expression

Davies et. al., 2017

Hover the mouse over a column in the graph to view average RPKM values per sample.
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Embryonic Stages: Y: yolk. S2-S8: Stages 2-8. C4: asexual adult. SX: virgin, sexually mature adult.
For further information about sample preparation and analysis for the single animal RNA-Seq experiment, please refer to the Materials and Methods

 

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Anatomical Expression

PAGE et. al., 2020



SMED30010746

has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGE



PAGE Curations: 1

  
Expressed InReference TranscriptGene ModelsPublished TranscriptTranscriptomePublicationSpecimenLifecycleEvidence
Category 3 cellSMED30010746SMESG000003961.1 dd_Smed_v4_33028_0_1dd_Smed_v4PMID:28292427
Wurtzel et al., 2017		whole organism asexual adult single-cell RNA-sequencing evidence
Note: Hover over icons to view figure legend
Homology
[Close]
BLAST of Bestrophin homolog vs. Ensembl Human
Match: BEST3 (bestrophin 3 [Source:HGNC Symbol;Acc:HGNC:17105])

HSP 1 Score: 225.713 bits (574), Expect = 9.730e-69
Identity = 141/407 (34.64%), Postives = 222/407 (54.55%), Query Frame = 1 
Query:   16 ISYSSKL*NFNCNMSTSYFGKHGRKNDYFKLLLRWDGSIYKILYXXXXXXXXXXXXXXXXNKNLLSEINQKYFSKFCEYCLYLSETIPIAFVLTFFVPLVVSRRFEQFKMIPWIDKMAIYLSAFLQGRTDDIVIKRRTVIRYMILSMTLCFRSISMPVMDAFESDEQLINAGLATQEEIVKIDSIPFSYNRYFVPLIWAGDIIHRADKHGLISGERCLALLLNEVMSFHEELQSILFYDWISIPLVYTQVSTICTYAYFICTVFGGQILGVKMFINFKNSTKPANNVTINYDEITEYLMYFPIFFVIQFVIYMGWLKVAESMINPYGYDDEDFQMVSLIERNLQIGFVIVDKINNFPPKVTEDV--------------VPIYIKPNF--NTLQMDKELFQNSQGMVD 1188
            ++YSSK+ N       ++FG H       +LLL+W GSIYK+LY EF +F  +Y  I++V + LL+ + ++YF K   YC   +E IP+ FVL F+V LVV+R + QF  +PW D++   +S+ + G  +   + RRT++RY+ L+  L FRS+S  V   F + + ++ AG  T +E    + +   + +Y+VP IW G++  +A   G I     L  L+ E+  +      +  YDW+ IPLVYTQV T+  Y +F   + G Q L         + TK      ++        +Y PIF ++QF  Y GWLKVAE +INP+G DD+DF+    I+RNLQ+  + VD+++   PK+ +D+                 Y  P+F  +T+QM K++ +N   M D
Sbjct:    3 VTYSSKVAN------ATFFGFH-------RLLLKWRGSIYKLLYREFIVFAVLYTAISLVYRLLLTGVQKRYFEKLSIYCDRYAEQIPVTFVLGFYVTLVVNRWWNQFVNLPWPDRLMFLISSSVHGSDEHGRLLRRTLMRYVNLTSLLIFRSVSTAVYKRFPTMDHVVEAGFMTTDERKLFNHLKSPHLKYWVPFIWFGNLATKARNEGRIRDSVDLQSLMTEMNRYRSWCSLLFGYDWVGIPLVYTQVVTLAVYTFFFACLIGRQFL---------DPTKGYAGHDLD--------LYIPIFTLLQFFFYAGWLKVAEQLINPFGEDDDDFETNWCIDRNLQVSLLAVDEMHMSLPKMKKDIYWDDSAARPPYTLAAADYCIPSFLGSTVQMGKQMPKNEWKMED 379
[Close]
BLAST of Bestrophin homolog vs. Ensembl Human
Match: BEST4 (bestrophin 4 [Source:HGNC Symbol;Acc:HGNC:17106])

HSP 1 Score: 224.172 bits (570), Expect = 2.336e-67
Identity = 133/353 (37.68%), Postives = 206/353 (58.36%), Query Frame = 1 
Query:   55 MSTSYFGK--HGRKNDYFKLLLRWDGSIYKILYXXXXXXXXXXXXXXXXNKNLLSEINQKYFSKFCEYCLYLSETIPIAFVLTFFVPLVVSRRFEQFKMIPWIDKMAIYLSAFLQGRTDDIVIKRRTVIRYMILSMTLCFRSISMPVMDAFESDEQLINAGLATQEEIVKIDSIPFSYNRYFVPLIWAGDIIHRADKHGLISGERCLALLLNEVMSFHEELQSILFYDWISIPLVYTQVSTICTYAYFICTVFGGQIL-----GVKMFINFKNSTKPANNVTINYDEITEYLMYFPIFFVIQFVIYMGWLKVAESMINPYGYDDEDFQMVSLIERNLQIGFVIVDKI-NNFPP 1089
            M+ SY  K    R   +  LLLRW GSIYK+LY EF +F A+Y ++++  + LL++  +  +++   YC   ++ IP++FVL F+V LVV+R + Q+  IP  D++   +SA + G      + RRT+IRY  L+  L  RS+S  V+  F + E +++AG  +QEE  K +S+   +N+Y+VP +W  ++  +A + G I  +  L LLL E+  +  +   +  YDWISIPLVYTQV TI  Y++F  ++ G Q +       K     K   +PA         + +  MY P+  ++QF  Y GWLKVAE +INP+G DD+DF+   LI+RNLQ+  + VD++  N PP
Sbjct:    1 MTVSYTLKVAEARFGGFSGLLLRWRGSIYKLLYKEFLLFGALYAVLSITYRLLLTQEQRYVYAQVARYCNRSADLIPLSFVLGFYVTLVVNRWWSQYTSIPLPDQLMCVISASVHGVDQRGRLLRRTLIRYANLASVLVLRSVSTRVLKRFPTMEHVVDAGFMSQEERKKFESLKSDFNKYWVPCVWFTNLAAQARRDGRIRDDIALCLLLEELNKYRAKCSMLFHYDWISIPLVYTQVVTIAVYSFFALSLVGRQFVEPEAGAAKPQKLLKPGQEPA-------PALGDPDMYVPLTTLLQFFFYAGWLKVAEQIINPFGEDDDDFETNQLIDRNLQVSLLSVDEMYQNLPP 346
[Close]
BLAST of Bestrophin homolog vs. Ensembl Human
Match: BEST2 (bestrophin 2 [Source:HGNC Symbol;Acc:HGNC:17107])

HSP 1 Score: 218.779 bits (556), Expect = 6.836e-65
Identity = 125/342 (36.55%), Postives = 193/342 (56.43%), Query Frame = 1 
Query:   55 MSTSYFGK--HGRKNDYFKLLLRWDGSIYKILYXXXXXXXXXXXXXXXXNKNLLSEINQKYFSKFCEYCLYLSETIPIAFVLTFFVPLVVSRRFEQFKMIPWIDKMAIYLSAFLQGRTDDIVIKRRTVIRYMILSMTLCFRSISMPVMDAFESDEQLINAGLATQEEIVKIDSIPFSYNRYFVPLIWAGDIIHRADKHGLISGERCLALLLNEVMSFHEELQSILFYDWISIPLVYTQVSTICTYAYFICTVFGGQILGVKMFINFKNSTKPANNVTINYDEITEYLMYFPIFFVIQFVIYMGWLKVAESMINPYGYDDEDFQMVSLIERNLQIGFVIVDKI 1074
            M+ +Y  +  + R   + +LLL W GSIYK+L+ E   F+  Y  ++   + +L+E  ++YF K   YC   +  IP++FVL F+V LVV+R + Q+  +P  D +   ++  + GR D   + RRT++RY  LS  L  RS+S  V   F + + ++ AG  T+EE  K +++  SYN+Y+VP +W  ++  +A + G I     L LLL E+  F  +   +  YDWIS+PLVYTQV TI  Y+YF+  + G Q L             PA     +     +  +  PIF ++QF  Y GWLKVAE +INP+G DD+DF+   LI+RN Q+  + VD++
Sbjct:    1 MTVTYTARVANARFGGFSQLLLLWRGSIYKLLWRELLCFLGFYMALSAAYRFVLTEGQKRYFEKLVIYCDQYASLIPVSFVLGFYVTLVVNRWWSQYLCMPLPDALMCVVAGTVHGRDDRGRLYRRTLMRYAGLSAVLILRSVSTAVFKRFPTIDHVVEAGFMTREERKKFENLNSSYNKYWVPCVWFSNLAAQARREGRIRDNSALKLLLEELNVFRGKCGMLFHYDWISVPLVYTQVVTIALYSYFLACLIGRQFL------------DPAQGYKDH-----DLDLCVPIFTLLQFFFYAGWLKVAEQLINPFGEDDDDFETNFLIDRNFQVSMLAVDEM 325
[Close]
BLAST of Bestrophin homolog vs. Ensembl Human
Match: BEST2 (bestrophin 2 [Source:HGNC Symbol;Acc:HGNC:17107])

HSP 1 Score: 218.779 bits (556), Expect = 6.836e-65
Identity = 125/342 (36.55%), Postives = 193/342 (56.43%), Query Frame = 1 
Query:   55 MSTSYFGK--HGRKNDYFKLLLRWDGSIYKILYXXXXXXXXXXXXXXXXNKNLLSEINQKYFSKFCEYCLYLSETIPIAFVLTFFVPLVVSRRFEQFKMIPWIDKMAIYLSAFLQGRTDDIVIKRRTVIRYMILSMTLCFRSISMPVMDAFESDEQLINAGLATQEEIVKIDSIPFSYNRYFVPLIWAGDIIHRADKHGLISGERCLALLLNEVMSFHEELQSILFYDWISIPLVYTQVSTICTYAYFICTVFGGQILGVKMFINFKNSTKPANNVTINYDEITEYLMYFPIFFVIQFVIYMGWLKVAESMINPYGYDDEDFQMVSLIERNLQIGFVIVDKI 1074
            M+ +Y  +  + R   + +LLL W GSIYK+L+ E   F+  Y  ++   + +L+E  ++YF K   YC   +  IP++FVL F+V LVV+R + Q+  +P  D +   ++  + GR D   + RRT++RY  LS  L  RS+S  V   F + + ++ AG  T+EE  K +++  SYN+Y+VP +W  ++  +A + G I     L LLL E+  F  +   +  YDWIS+PLVYTQV TI  Y+YF+  + G Q L             PA     +     +  +  PIF ++QF  Y GWLKVAE +INP+G DD+DF+   LI+RN Q+  + VD++
Sbjct:    1 MTVTYTARVANARFGGFSQLLLLWRGSIYKLLWRELLCFLGFYMALSAAYRFVLTEGQKRYFEKLVIYCDQYASLIPVSFVLGFYVTLVVNRWWSQYLCMPLPDALMCVVAGTVHGRDDRGRLYRRTLMRYAGLSAVLILRSVSTAVFKRFPTIDHVVEAGFMTREERKKFENLNSSYNKYWVPCVWFSNLAAQARREGRIRDNSALKLLLEELNVFRGKCGMLFHYDWISVPLVYTQVVTIALYSYFLACLIGRQFL------------DPAQGYKDH-----DLDLCVPIFTLLQFFFYAGWLKVAEQLINPFGEDDDDFETNFLIDRNFQVSMLAVDEM 325
[Close]
BLAST of Bestrophin homolog vs. Ensembl Human
Match: BEST2 (bestrophin 2 [Source:HGNC Symbol;Acc:HGNC:17107])

HSP 1 Score: 218.779 bits (556), Expect = 6.836e-65
Identity = 125/342 (36.55%), Postives = 193/342 (56.43%), Query Frame = 1 
Query:   55 MSTSYFGK--HGRKNDYFKLLLRWDGSIYKILYXXXXXXXXXXXXXXXXNKNLLSEINQKYFSKFCEYCLYLSETIPIAFVLTFFVPLVVSRRFEQFKMIPWIDKMAIYLSAFLQGRTDDIVIKRRTVIRYMILSMTLCFRSISMPVMDAFESDEQLINAGLATQEEIVKIDSIPFSYNRYFVPLIWAGDIIHRADKHGLISGERCLALLLNEVMSFHEELQSILFYDWISIPLVYTQVSTICTYAYFICTVFGGQILGVKMFINFKNSTKPANNVTINYDEITEYLMYFPIFFVIQFVIYMGWLKVAESMINPYGYDDEDFQMVSLIERNLQIGFVIVDKI 1074
            M+ +Y  +  + R   + +LLL W GSIYK+L+ E   F+  Y  ++   + +L+E  ++YF K   YC   +  IP++FVL F+V LVV+R + Q+  +P  D +   ++  + GR D   + RRT++RY  LS  L  RS+S  V   F + + ++ AG  T+EE  K +++  SYN+Y+VP +W  ++  +A + G I     L LLL E+  F  +   +  YDWIS+PLVYTQV TI  Y+YF+  + G Q L             PA     +     +  +  PIF ++QF  Y GWLKVAE +INP+G DD+DF+   LI+RN Q+  + VD++
Sbjct:    1 MTVTYTARVANARFGGFSQLLLLWRGSIYKLLWRELLCFLGFYMALSAAYRFVLTEGQKRYFEKLVIYCDQYASLIPVSFVLGFYVTLVVNRWWSQYLCMPLPDALMCVVAGTVHGRDDRGRLYRRTLMRYAGLSAVLILRSVSTAVFKRFPTIDHVVEAGFMTREERKKFENLNSSYNKYWVPCVWFSNLAAQARREGRIRDNSALKLLLEELNVFRGKCGMLFHYDWISVPLVYTQVVTIALYSYFLACLIGRQFL------------DPAQGYKDH-----DLDLCVPIFTLLQFFFYAGWLKVAEQLINPFGEDDDDFETNFLIDRNFQVSMLAVDEM 325
[Close]
BLAST of Bestrophin homolog vs. Ensembl Celegans
Match: best-23 (Bestrophin homolog [Source:UniProtKB/TrEMBL;Acc:A5JYR2])

HSP 1 Score: 200.675 bits (509), Expect = 1.648e-59
Identity = 117/338 (34.62%), Postives = 198/338 (58.58%), Query Frame = 1 
Query:   91 NDYFKLLLRWDGSIYKILYXXXXXXXXXXXXXXXXNKNLLSEINQKYFSKFCEYCLYLSETIPIAFVLTFFVPLVVSRRFEQFKMIPWIDKMAIYLSAFLQGRTDDIVIKRRTVIRYMILSMTLCFRSISMPVMDAFESDEQLINAGLATQEEIVKIDSIPFS---YNRYFVPLIWAGDIIHRADKHGLISGERCLALLLNEVMSFHEELQSILFYDWISIPLVYTQVSTICTYAYFICTVFGGQILGVKMFINFKNSTKPANNVTINYDEITEYLMYFPIFFVIQFVIYMGWLKVAESMINPYGYDDEDFQMVSLIERNLQIGFVIVDKINNFPPKV 1095
            + + KLL RW GS++K ++    IF+ +YYII    +  +++  Q  F K+       ++ IP+ F+L F+V ++V R ++  ++I W D +   +SA ++G+  +  I R+T+ RY IL+  L +RSIS+ V+  + +D+ L+++GL T+EE+V   SI      + +++VPL W   ++ R  + G ++    L +LL+ +  +      +  YDWI+IPLVYTQVSTI  Y YF+  + G Q               P+ N     +EI +  +Y PIF ++QF+ Y+GWLKV E ++ P+G DDEDF+   ++ERNL++  +IVD+++N  P V
Sbjct:    7 DTFLKLLFRWKGSLWKAIWKHLLIFLTMYYIINAYYRFGMTKEQQNEFIKYVMLVDGWTKEIPLTFLLGFYVAMIVRRWWDCCQLISWPDHLLYNVSALIRGQDPETRIIRKTIARYTILTSVLAWRSISLRVLARYPTDDHLVDSGLMTKEEMVMFKSILVHVDPHQKWWVPLNWIQTMMVRCFEKGTLTHTNELRVLLDALEKYRNGFFQLFIYDWIAIPLVYTQVSTISVYGYFLFALIGRQY--------------PSKNEN---EEIVD--VYVPIFTILQFLFYVGWLKVGEDLMFPFGADDEDFEFNYILERNLEVSMLIVDELHNQVPPV 325
[Close]
BLAST of Bestrophin homolog vs. Ensembl Celegans
Match: best-24 (Bestrophin homolog 24 [Source:UniProtKB/Swiss-Prot;Acc:P34672])

HSP 1 Score: 200.675 bits (509), Expect = 1.489e-57
Identity = 119/366 (32.51%), Postives = 202/366 (55.19%), Query Frame = 1 
Query:   40 NFNCNMSTSYFGKHGRKNDYFKLLLRWDGSIYKILYXXXXXXXXXXXXXXXXNKNLLSEINQKYFSKFCEYCLYLSETIPIAFVLTFFVPLVVSRRFEQFKMIPWIDKMAIYLSAFLQGRTDDIVIKRRTVIRYMILSMTLCFRSISMPVMDAFESDEQLINAGLATQEEIVKIDSIPFSYNRYFVPLIWAGDIIHRADKHGLISGERCLALLLNEVMSFHEELQSILFYDWISIPLVYTQVSTICTYAYFICTVFGGQILGVKMFINFKNSTKPANNVTINYDEITEYLMYFPIFFVIQFVIYMGWLKVAESMINPYGYDDEDFQMVSLIERNLQIGFVIVDKINNFPPKVT------EDVVPIY 1119
            N+N  +STS      +    FKLLL+W GSI+K +  E  +++ +Y I++V+ +  L+   Q+ F +  +YC      IP+ F+L FFV  VV+R    +++I +ID + +  + +++GRT+   + RR ++RY  L+  L FR ISM     F + + ++ AG     E  + D I + Y++Y+VP  WA  + + A K GLI  +    ++ +E+  F   L  I  YDW+ IP++Y Q+  +  + YF+  +   Q +                 V+ + D  TE  +YFPI   +QF+ YMGW+KVAE+M+NP+G DD+DF+  +LI+RN+ +  ++VD+  +  P +       E+V P+Y
Sbjct:    4 NYNLAVSTS------KPWTLFKLLLKWRGSIWKAVILELAVWLVLYGILSVIYRTALNPGQQRTFERIVQYCDSRLSYIPLNFMLGFFVTAVVNRWTYLYQIIGFIDNIGLMAAEYVRGRTEQARMYRRNIVRYCELAQVLVFRDISMRTRRRFPTLDTVVAAGFMMPHEKDRFDEIQYKYSKYWVPFQWAFSLTYEARKKGLIESDYYQVVVQDEIKKFRTGLAWICNYDWVPIPIMYPQLVCLAVHTYFLVCLLARQYV-----------------VSEHADNKTEIDLYFPIMSTLQFIFYMGWMKVAEAMLNPFGEDDDDFECNALIDRNITMVLMMVDQGYDRAPDLKRDDFWDEEVEPLY 346
[Close]
BLAST of Bestrophin homolog vs. Ensembl Celegans
Match: best-4 (Bestrophin homolog [Source:UniProtKB/TrEMBL;Acc:O17205])

HSP 1 Score: 197.978 bits (502), Expect = 4.137e-57
Identity = 124/401 (30.92%), Postives = 217/401 (54.11%), Query Frame = 1 
Query:  103 KLLLRWDGSIYKILYXXXXXXXXXXXXXXXXNKNLLSEINQKYFSKFCEYCLYLSETIPIAFVLTFFVPLVVSRRFEQFKMIPWIDKMAIYLSAFLQGRTDDIVIKRRTVIRYMILSMTLCFRSISMPVMDAFESDEQLINAGLATQEEIVKIDSIPFSYNRYFVPLIWAGDIIHRADKHGLISGERCLALLLNEVMSFHEELQSILFYDWISIPLVYTQVSTICTYAYFICTVFGGQILGVKMFINFKNSTKPANNVTINYDEITEYLMYFPIFFVIQFVIYMGWLKVAESMINPYGYDDEDFQMVSLIERNLQIGFVIVDKINNFPPKVTEDVVPIY---IKPNFNTLQMDKELFQNSQGMVDDDNAEFLEKSTVMY--RKNLLFGSNIMDDINIIGTE 1290
            K+LLRW GS++K +++E  I++  Y I++V+ + LL++  ++ F + C +    S  IP+ F+L F+V +V +R  + F  + WID  A+ ++ +++G ++   + RR  +RYMI++  + FR +S  +   F + + LI AGL T++E+ + D+I    ++Y+ P+ W   ++  A   GLI+       L++++  F  ++ +++ +D + IPLVYTQV  +    YF+  +FG Q L         N+  P     I+        +YFPI   +Q V  +GWLKV+E M+NP G DDEDF+   +IERNLQ+G+ +VD+     P +  D  P +        +T    ++   + QG   + N   L+   + Y  R++  FG    DD +   TE
Sbjct:   19 KVLLRWKGSVWKSIWSELLIWLLCYSILSVIYRILLNKAQREVFEQLCTFFDTFSVFIPVTFMLGFYVSIVYNRWTKVFDNVGWIDTSALTIAQYIRGTSEKARLIRRNCVRYMIVAQVMVFRDVSPAIRRRFPTIKHLIGAGLLTEDELTEFDAITSPQSKYWQPIQWLFSLVTVAKDEGLIADSYLYVDLIDKMREFRTKILNLVIFDMVPIPLVYTQVVNLAVRTYFVLALFGRQFLE-------NNNNIPGAKWKID--------IYFPIMTSLQIVFIVGWLKVSEVMLNPLGEDDEDFETNWIIERNLQVGYAVVDQAYGRYPTLKRD--PFWEDETPQTMDTPTSTRKAHSHMQGSCINMNEADLDNGLISYVRRRSRSFGD---DDASSFSTE 399
[Close]
BLAST of Bestrophin homolog vs. Ensembl Celegans
Match: best-3 (Bestrophin homolog [Source:UniProtKB/TrEMBL;Acc:O17206])

HSP 1 Score: 197.978 bits (502), Expect = 1.227e-56
Identity = 108/335 (32.24%), Postives = 192/335 (57.31%), Query Frame = 1 
Query:  100 FKLLLRWDGSIYKILYXXXXXXXXXXXXXXXXNKNLLSEINQKYFSKFCEYCLYLSETIPIAFVLTFFVPLVVSRRFEQFKMIPWIDKMAIYLSAFLQGRTDDIVIKRRTVIRYMILSMTLCFRSISMPVMDAFESDEQLINAGLATQEEIVKIDSIPFSYNRYFVPLIWAGDIIHRADKHGLISGERCLALLLNEVMSFHEELQSILFYDWISIPLVYTQVSTICTYAYFICTVFGGQILGVKMFINFKNSTKPANNVTINYDEITEYLMYFPIFFVIQFVIYMGWLKVAESMINPYGYDDEDFQMVSLIERNLQIGFVIVDKINNFPPKVTED 1104
            +KLL RW GSI+K ++ E  +++ +Y +++V+ + LL+   +  F   C +    S  IPI F+L F+V  V +R ++ F  I WID   ++++ +++G T+     RR  IRY IL+  + +R ++  V   F +   L+ AGL T++E+ + +SIP  + +Y+ P+ W   +I  A   G+IS +     L+ ++  F   + S+  +DW+ +PLVYTQV  +   +YF+  +FG Q L             P +N   ++ +  +  +Y PI  ++QF+ ++GW+KVAE ++NP G DD+DF+   +++RNLQ+G ++VD   N  P + +D
Sbjct:   18 YKLLFRWKGSIWKSVWAELVVWLCLYAVLSVIYRCLLTMKQRATFEDLCIFFDTYSNFIPITFMLGFYVSAVFTRWWQIFDNIGWIDTPCLWITQYIKGETERAKCVRRNCIRYSILTQAMVYRDVAASVRKRFPTFNHLVTAGLMTEKEMAEFESIPSPHAKYWQPMHWLFSMITLARDEGMISSDIIYVDLMEKMRQFRVNILSLTLFDWVPVPLVYTQVVHLAVRSYFLIALFGRQYL------------HPESNRLNDFKQTID--LYVPIMSLLQFIFFIGWMKVAEVLLNPLGEDDDDFECNWILDRNLQVGLMVVDTAYNRYPTLEKD 338
[Close]
BLAST of Bestrophin homolog vs. Ensembl Celegans
Match: best-14 (Bestrophin homolog 14 [Source:UniProtKB/Swiss-Prot;Acc:Q19978])

HSP 1 Score: 189.504 bits (480), Expect = 2.353e-55
Identity = 109/341 (31.96%), Postives = 188/341 (55.13%), Query Frame = 1 
Query:   91 NDYFKLLLRWDGSIYKILYXXXXXXXXXXXXXXXXNKNLLSEINQKYFSKFCEYCLYLSETIPIAFVLTFFVPLVVSRRFEQFKMIPWIDKMAIYLSAFLQGRTDDIVIKRRTVIRYMILSMTLCFRSISMPVMDAFESDEQLINAGLATQEEIVKIDSIPFSYNRYFVPLIWAGDIIHRADKHGLISGERCLALLLNEVMSFHEELQSILFYDWISIPLVYTQVSTICTYAYFICTVFGGQILGVKMFINFKNSTKPANNVTINYDEITEYLMYFPIFFVIQFVIYMGWLKVAESMINPYGYDDEDFQMVSLIERNLQIGFVIVDKINNFPPKVTEDVVP 1113
             ++  L+LRW GSI+K +  +   F   YYI+      LL E  ++YF+ +  +C   ++ IP++F+L FFV L+V+R +EQF  I W DKM I +SA L G  + +V  R+T+ R+  L   + +  +S+  +  F ++  ++ + L T+EE     +    + ++F+P++W  ++I +  + G+I   + + +LL +V S+ +    +  YDWI IPLVYTQV  I TY YF   + G Q               P  +      EIT   + FPIF   Q + Y+GWLKV + ++NP+G DD+DF++  +++RN  I  ++  ++++  P +   +VP
Sbjct:    7 EEFSSLMLRWRGSIWKAVLKDLIGFYIAYYIVLAFQWYLLDEKGKEYFTGWIMWCEIGAQYIPLSFLLGFFVSLIVARWWEQFNCISWPDKMMIMVSACLPGNENMVV--RQTIARWSSLQAAIAWSGVSVKTLKRFPTERHMVASKLMTEEEYDLYMNTDAPHGKWFIPILWIVNLIKKQKQKGIIDSIQ-MDMLLKQVYSYRDGFAMLFVYDWIKIPLVYTQVVAIATYGYFFICLIGRQ---------------PKLDQRSMEKEIT---ILFPIFTTFQMLFYLGWLKVGQYLMNPFGEDDDDFELNYVLDRNTAIAHMMASELSDQLPSIGAPMVP 326
[Close]
BLAST of Bestrophin homolog vs. Ensembl Fly
Match: Best3 (gene:FBgn0036492 transcript:FBtr0075618)

HSP 1 Score: 224.172 bits (570), Expect = 4.015e-67
Identity = 126/366 (34.43%), Postives = 221/366 (60.38%), Query Frame = 1 
Query:   16 ISYSSKL*NFNCNMSTSYFGKHGRKNDYFKLLLRWDGSIYKILYXXXXXXXXXXXXXXXXNKNLLSEINQKYFSKFCEYCLYLSETIPIAFVLTFFVPLVVSRRFEQFKMIPWIDKMAIYLSAFLQGRTDDIVIKRRTVIRYMILSMTLCFRSISMPVMDAFESDEQLINAGL--ATQEEIVKIDSIPF-SYNRYFVPLIWAGDIIHRADKHGLISGERCLALLLNEVMSFHEELQSILFYDWISIPLVYTQVSTICTYAYFICTVFGGQILGVKMFINFKNSTKPANNVTINYDEITEYLMYFPIFFVIQFVIYMGWLKVAESMINPYGYDDEDFQMVSLIERNLQIGFVIVDKINNFPPKVTED 1104
            +SY++++       + S+FG       ++KLL+RW  SIYKI++ +   F++ +Y +AV+ +  L ++++  F     YC   S  IP++FVL F+V +++ R + Q+  +PW D +A+Y+SA ++G+ +   + RRT++RY+ L++T+    IS  +   F + +QLI  GL  A +  I+K   + F  + +Y++P++WA  I+ RA K G I  +  L  +++E+  F      ++ YD IS+PLVYTQV T+  Y+YF+ ++FG Q +   +                +Y+ I  Y  YFP+F  ++F  +MGWLKVAE++I P+G DD+DF++  LI+RNLQ+ ++IVD+++N  P++  D
Sbjct:    3 VSYTAEV------ATCSHFGC------FWKLLMRWRASIYKIIWVDLLAFLSCFYFMAVIYRYALRDVDKPVFEDIVMYCHSYSNLIPLSFVLGFYVGIIIERWWNQYITVPWPDPLAVYVSALVRGQDEHGRLMRRTIMRYVCLALTMVLSMISPVIKRRFPTYDQLIEVGLLNANEANIMKAMDVKFPKHPKYWMPIVWAASIVTRARKEGRIWDDFSLKSMIDELNKFRAGCNMLIHYDTISVPLVYTQVVTLAVYSYFVASIFGHQWIDRDI---------------KHYNNIVSY--YFPLFSTLEFFFFMGWLKVAETLICPFGDDDDDFELNWLIDRNLQVSYLIVDEMHNDHPQLVRD 339
[Close]
BLAST of Bestrophin homolog vs. Ensembl Fly
Match: Best4 (gene:FBgn0036491 transcript:FBtr0113172)

HSP 1 Score: 219.164 bits (557), Expect = 3.385e-65
Identity = 119/341 (34.90%), Postives = 202/341 (59.24%), Query Frame = 1 
Query:   91 NDYFKLLLRWDGSIYKILYXXXXXXXXXXXXXXXXNKNLLSEINQKYFSKFCEYCLYLSETIPIAFVLTFFVPLVVSRRFEQFKMIPWIDKMAIYLSAFLQGRTDDIVIKRRTVIRYMILSMTLCFRSISMPVMDAFESDEQLINAGLATQEE---IVKIDSIPFSYNRYFVPLIWAGDIIHRADKHGLISGERCLALLLNEVMSFHEELQSILFYDWISIPLVYTQVSTICTYAYFICTVFGGQILGVKMFINFKNSTKPANNVTINYDEITEYLMYFPIFFVIQFVIYMGWLKVAESMINPYGYDDEDFQMVSLIERNLQIGFVIVDKINNFPPKVTED 1104
            +++  LL+RW GSIYK+++ +  +F  +Y ++A+  + L++E  +++F     YC      IP++FVL FFV +V++R ++Q+  IPW D +AI +S  + G  D   + RRT++RY+ L   + F  IS  V   F +  Q+I AG   + E   I  +D    SY ++++P++WA  I+ RA +   I  +  +  +++E+         +L+YDWIS+PLVYTQV T+ TY++F+ +V G Q                  N + + ++ T    +FPI  V+QF  YMGWLKVAE++INP+G DD+DF++  +I+RNL + + IVD+++   P++ +D
Sbjct:   16 SNFLGLLVRWRGSIYKLIWLDLIVFFGLYCLLAITYRLLVNEEGKRFFEAIMSYCEKNGSLIPLSFVLGFFVRIVMNRWWDQYTTIPWPDGIAILISTSIHGSDDRARVMRRTILRYVCLCQVIVFTMISPRVKRRFPTYTQIIEAGFLLENEKKIIEAMDQAFPSYPKHWMPIVWAASIVMRARRENKIRDDYAVKTIIDELNQLRGNCGFLLYYDWISVPLVYTQVVTVATYSFFLFSVLGQQW-----------------NESHSDEDGTRIRRWFPILTVLQFFFYMGWLKVAETLINPFGEDDDDFELNWIIDRNLTVSYCIVDEMHQEHPELVKD 339
[Close]
BLAST of Bestrophin homolog vs. Ensembl Fly
Match: Best1 (gene:FBgn0040238 transcript:FBtr0082183)

HSP 1 Score: 217.624 bits (553), Expect = 3.741e-63
Identity = 120/344 (34.88%), Postives = 207/344 (60.17%), Query Frame = 1 
Query:   97 YFKLLLRWDGSIYKILYXXXXXXXXXXXXXXXXNKNLLSEINQKYFSKFCEYCLYLSETIPIAFVLTFFVPLVVSRRFEQFKMIPWIDKMAIYLSAFLQGRTDDIVIKRRTVIRYMILSMTLCFRSISMPVMDAFESDEQLINAGLATQEEIVKIDSIPFSYNR---YFVPLIWAGDIIHRADKHGLISGERCLALLLNEVMSFHEELQSILFYDWISIPLVYTQVSTICTYAYFICTVFG-----GQILGVKMFINFKNSTKPANNVTINYDEITEYLMYFPIFFVIQFVIYMGWLKVAESMINPYGYDDEDFQMVSLIERNLQIGFVIVDKINNFPPKVTED 1104
            + KLLLRW GSIYK+++ +   F+ IYY I +V +  L+   ++ F    +YC    E IP++FVL F+V +V++R + Q+  IPW D +A+++S+ + G+ +   + RRT++RY+ L +T+   ++S  V   F     L+ AGL    E   I+++  ++ R   +++P++WA  II RA K G I  +  +  +++E+  F  +   ++ YD IS+PLVYTQV T+  Y+YF+    G     G+++G   ++N                   +  +YFP+F  +QF  YMGWLKVAES+INP+G DD+DF++  +++RNLQ+ ++IVD++++  P++ +D
Sbjct:   18 FLKLLLRWRGSIYKLVWLDLLAFLTIYYAINMVYRFGLNPAQKETFEAIVQYCDSYRELIPLSFVLGFYVSIVMTRWWNQYTSIPWPDPIAVFVSSNVHGQDERGRMMRRTIMRYVCLCLTMVLANVSPRVKKRFPGLNNLVEAGLLNDNEKTIIETMNKAFPRPSKHWLPIVWAASIITRARKEGRIRDDFAVKTIIDELNKFRGQCGLLISYDTISVPLVYTQVVTLAVYSYFLTCCMGQQWTDGKVVGNTTYLN-------------------KVDLYFPVFTTLQFFFYMGWLKVAESLINPFGEDDDDFEVNWMVDRNLQVSYLIVDEMHHDHPELLKD 342
[Close]
BLAST of Bestrophin homolog vs. Ensembl Fly
Match: Best1 (gene:FBgn0040238 transcript:FBtr0337020)

HSP 1 Score: 217.624 bits (553), Expect = 5.520e-63
Identity = 120/344 (34.88%), Postives = 207/344 (60.17%), Query Frame = 1 
Query:   97 YFKLLLRWDGSIYKILYXXXXXXXXXXXXXXXXNKNLLSEINQKYFSKFCEYCLYLSETIPIAFVLTFFVPLVVSRRFEQFKMIPWIDKMAIYLSAFLQGRTDDIVIKRRTVIRYMILSMTLCFRSISMPVMDAFESDEQLINAGLATQEEIVKIDSIPFSYNR---YFVPLIWAGDIIHRADKHGLISGERCLALLLNEVMSFHEELQSILFYDWISIPLVYTQVSTICTYAYFICTVFG-----GQILGVKMFINFKNSTKPANNVTINYDEITEYLMYFPIFFVIQFVIYMGWLKVAESMINPYGYDDEDFQMVSLIERNLQIGFVIVDKINNFPPKVTED 1104
            + KLLLRW GSIYK+++ +   F+ IYY I +V +  L+   ++ F    +YC    E IP++FVL F+V +V++R + Q+  IPW D +A+++S+ + G+ +   + RRT++RY+ L +T+   ++S  V   F     L+ AGL    E   I+++  ++ R   +++P++WA  II RA K G I  +  +  +++E+  F  +   ++ YD IS+PLVYTQV T+  Y+YF+    G     G+++G   ++N                   +  +YFP+F  +QF  YMGWLKVAES+INP+G DD+DF++  +++RNLQ+ ++IVD++++  P++ +D
Sbjct:   18 FLKLLLRWRGSIYKLVWLDLLAFLTIYYAINMVYRFGLNPAQKETFEAIVQYCDSYRELIPLSFVLGFYVSIVMTRWWNQYTSIPWPDPIAVFVSSNVHGQDERGRMMRRTIMRYVCLCLTMVLANVSPRVKKRFPGLNNLVEAGLLNDNEKTIIETMNKAFPRPSKHWLPIVWAASIITRARKEGRIRDDFAVKTIIDELNKFRGQCGLLISYDTISVPLVYTQVVTLAVYSYFLTCCMGQQWTDGKVVGNTTYLN-------------------KVDLYFPVFTTLQFFFYMGWLKVAESLINPFGEDDDDFEVNWMVDRNLQVSYLIVDEMHHDHPELLKD 342
[Close]
BLAST of Bestrophin homolog vs. Ensembl Fly
Match: Best1 (gene:FBgn0040238 transcript:FBtr0114590)

HSP 1 Score: 217.624 bits (553), Expect = 8.347e-63
Identity = 120/344 (34.88%), Postives = 207/344 (60.17%), Query Frame = 1 
Query:   97 YFKLLLRWDGSIYKILYXXXXXXXXXXXXXXXXNKNLLSEINQKYFSKFCEYCLYLSETIPIAFVLTFFVPLVVSRRFEQFKMIPWIDKMAIYLSAFLQGRTDDIVIKRRTVIRYMILSMTLCFRSISMPVMDAFESDEQLINAGLATQEEIVKIDSIPFSYNR---YFVPLIWAGDIIHRADKHGLISGERCLALLLNEVMSFHEELQSILFYDWISIPLVYTQVSTICTYAYFICTVFG-----GQILGVKMFINFKNSTKPANNVTINYDEITEYLMYFPIFFVIQFVIYMGWLKVAESMINPYGYDDEDFQMVSLIERNLQIGFVIVDKINNFPPKVTED 1104
            + KLLLRW GSIYK+++ +   F+ IYY I +V +  L+   ++ F    +YC    E IP++FVL F+V +V++R + Q+  IPW D +A+++S+ + G+ +   + RRT++RY+ L +T+   ++S  V   F     L+ AGL    E   I+++  ++ R   +++P++WA  II RA K G I  +  +  +++E+  F  +   ++ YD IS+PLVYTQV T+  Y+YF+    G     G+++G   ++N                   +  +YFP+F  +QF  YMGWLKVAES+INP+G DD+DF++  +++RNLQ+ ++IVD++++  P++ +D
Sbjct:   18 FLKLLLRWRGSIYKLVWLDLLAFLTIYYAINMVYRFGLNPAQKETFEAIVQYCDSYRELIPLSFVLGFYVSIVMTRWWNQYTSIPWPDPIAVFVSSNVHGQDERGRMMRRTIMRYVCLCLTMVLANVSPRVKKRFPGLNNLVEAGLLNDNEKTIIETMNKAFPRPSKHWLPIVWAASIITRARKEGRIRDDFAVKTIIDELNKFRGQCGLLISYDTISVPLVYTQVVTLAVYSYFLTCCMGQQWTDGKVVGNTTYLN-------------------KVDLYFPVFTTLQFFFYMGWLKVAESLINPFGEDDDDFEVNWMVDRNLQVSYLIVDEMHHDHPELLKD 342
[Close]
BLAST of Bestrophin homolog vs. Ensembl Zebrafish
Match: best1 (bestrophin 1 [Source:ZFIN;Acc:ZDB-GENE-110411-214])

HSP 1 Score: 234.572 bits (597), Expect = 1.024e-69
Identity = 126/341 (36.95%), Postives = 202/341 (59.24%), Query Frame = 1 
Query:   82 GRKNDYFKLLLRWDGSIYKILYXXXXXXXXXXXXXXXXNKNLLSEINQKYFSKFCEYCLYLSETIPIAFVLTFFVPLVVSRRFEQFKMIPWIDKMAIYLSAFLQGRTDDIVIKRRTVIRYMILSMTLCFRSISMPVMDAFESDEQLINAGLATQEEIVKIDSIPFSYNRYFVPLIWAGDIIHRADKHGLISGERCLALLLNEVMSFHEELQSILFYDWISIPLVYTQVSTICTYAYFICTVFGGQILGVKMFINFKNSTKPANNVTINYDEITEYLMYFPIFFVIQFVIYMGWLKVAESMINPYGYDDEDFQMVSLIERNLQIGFVIVDKINNFPPKVTED 1104
             R   +++LLLRW GSIYK+LY E  IF  +Y II++  + +L+E  ++ F K   YC   ++ IP++FVL F+V LVVSR + QF+ +PW D+++  +S  ++G  +   + RR+++RY  LS  L +RS+S  V   F +   L+ AGL T EE+ ++  +P  +N+++VP +W   +  RA   G I+ +  +  +LNE+ +   +   +  YDWIS+PLVYTQV T+  Y++F+  + G Q L             P +N+            Y P+F ++QF  Y+GWLKVAE +INP+G DD+DF+   L++RNLQ+  + VD++ +  P V  D
Sbjct:   12 ARLGTFYRLLLRWKGSIYKLLYRELLIFTVMYCIISITYRCVLTEEQRRMFEKLSLYCDQYAQLIPVSFVLGFYVTLVVSRWWGQFESVPWPDRLSALVSGHVRGADEGARLIRRSLMRYANLSGILIYRSVSTAVYKRFPTMSHLVQAGLMTAEELRQLQELPSPHNKFWVPCMWFVSLAMRARSEGRINNDVAMTAILNELNTLRSQCMRLYGYDWISLPLVYTQVVTVAVYSFFLTCLIGRQFLDPAQGY-------PGHNLDF----------YLPVFTLLQFFFYVGWLKVAEQLINPFGEDDDDFETNWLVDRNLQVSLLSVDEMYDLVPLVERD 335
[Close]
BLAST of Bestrophin homolog vs. Ensembl Zebrafish
Match: best4 (bestrophin 4 [Source:ZFIN;Acc:ZDB-GENE-070912-6])

HSP 1 Score: 211.846 bits (538), Expect = 3.404e-64
Identity = 127/376 (33.78%), Postives = 213/376 (56.65%), Query Frame = 1 
Query:   55 MSTSYFGK--HGRKNDYFKLLLRWDGSIYKILYXXXXXXXXXXXXXXXXNKNLLSEINQKYFSKFCEYCLYLSETIPIAFVLTFFVPLVVSRRFEQFKMIPWIDKMAIYLSAFLQGRTDDIVIKRRTVIRYMILSMTLCFRSISMPVMDAFESDEQLINAGLATQEEIVKIDSIPFSYNRYFVPLIWAGDIIHRADKHGLISGERCLALLLNEVMSFHEELQSILFYDWISIPLVYTQVSTICTYAYFICTVFGGQILGVKMFINFKNSTKPANNVTINYDEITEYL-MYFPIFFVIQFVIYMGWLKVAESMINPYGYDDEDFQMVSLIERNLQIGFVIVDKINNFPPKVTEDVVPIYIKPNFNTLQMDKELFQNS 1173
            M+ SY  K  + +   + KLL RW GSIYK+LY EF +F  +Y  I+++ + +L+   Q+ F++   +C   ++ IP++FVL F+V     R + Q+   P  D + + +S  + G  +   + RRT++RY  LS  L  RSIS  V   F + E ++ AG  T +E+ K++ +   +N+Y++PL W  ++  +A K G +  +  L LL++E+ ++  +   +  YDWISIPLVYTQV T+  Y++F  ++ G Q +            KPA++         E+L +Y PIF +++F  Y GWLKV E +INP+G DD+DF+   LI+RN+Q+  + VD ++   P + +D   +   P++ +  M K +F  S
Sbjct:    1 MTVSYTLKVANAKFGGFSKLLFRWKGSIYKLLYREFLVFCLLYTFISILYRCVLNNNQQEIFARLARHCNKFAKLIPMSFVLGFYVTQAFQRWWGQYTSFPLPDNLMMVVSGNVHGTDERGRLLRRTLMRYANLSSVLILRSISTRVRKRFTTLEDIVEAGFMTTDELRKLNHLYSDFNKYWMPLAWFANLASQARKEGRVKDDIALRLLMDELNNYRSKCSMLFHYDWISIPLVYTQVVTVAVYSFFTFSLIGRQFV------------KPASS--------EEHLDLYIPIFTLLEFFFYAGWLKVGELIINPFGEDDDDFETNQLIDRNIQVSMLAVDDMHQNLPPLEKDKYWVDKGPSYPSASM-KPVFMGS 355
[Close]
BLAST of Bestrophin homolog vs. Ensembl Zebrafish
Match: best2 (bestrophin 2 [Source:ZFIN;Acc:ZDB-GENE-090312-127])

HSP 1 Score: 208.764 bits (530), Expect = 5.091e-62
Identity = 141/418 (33.73%), Postives = 216/418 (51.67%), Query Frame = 1 
Query:   55 MSTSYFGK--HGRKNDYFKLLLRWDGSIYKILYXXXXXXXXXXXXXXXXNKNLLSEINQKYFSKFCEYCLYLSETIPIAFVLT--FFVPLVVSRRFEQFKMIPWIDKMAIYLSAFLQGRTDDIVIKRRTVIRYMILSMTLCFRSISMPVMDAFESDEQLINAGLATQEEIVKIDSIPFSYNRYFVPLIWAGDIIHRADKHGLISGERCLALLLNEVMSFHEELQSILFYDWISIPLVYTQVSTICTYAYFICTVFGGQILGVKMFINFKNSTKPANNVTINYDEITEYLMYFPIFFVIQFVIYMGWLKVAESMINPYGYDDEDFQMVSLIERNLQIGFVIVDKI---------------NNFPPKVTEDVVPIYIKPNFNTLQMDKELFQNSQGMVD-DDNAEFLEKSTVMYRKNLLF 1248
            M+ +Y  +  + R   + KLLL W GSIYK+LY EF  F A+Y  I++  +  L +  ++YF K   YC   +  IP++FVL   F+V LVV+R + Q+  IP  D++   LS  +QG  +   + RRT++RY  LS  L  RS+S  V   F + + ++ AG  T+EE  K +S+   YN+Y++P +W  ++   A   G I  +    LLL E+ +F  +   +  YD IS+PLVYTQV T+  Y++F+  + G Q L             P +++ +          Y PIF ++QF  Y GWLKVAE +INP+G DD+DF+   LI+RN Q+  + VD++               +N  P  T   + +  KP+F     D  + +        +D AE LE+S        LF
Sbjct:    1 MTVTYTARVANARFCGFSKLLLAWKGSIYKVLYKEFLAFFAMYTAISITYRFFLVDGQKRYFEKLSIYCDNYASLIPMSFVLGMRFYVTLVVNRWWSQYTSIPLPDRVMCVLSGGVQGSDERGRLLRRTLMRYSSLSALLILRSVSTAVFKRFPTIDHVVEAGFMTREERKKFESLHSPYNKYWIPCVWFTNLAAAARCEGRIKDDNTYKLLLEELNNFRGKCSMLFHYDMISVPLVYTQVVTLAVYSFFLVCLIGRQFLD-------PGQGYPGHDLDL----------YVPIFTLLQFFFYAGWLKVAEQLINPFGEDDDDFETNWLIDRNFQVSMMAVDEMYGDLPMMERDRYWNDSNPRPPYTAATLFVLRKPSFQGSTFDMTIPKEEMHFQPLEDIAENLEESGTRNHNLALF 401
[Close]
BLAST of Bestrophin homolog vs. Ensembl Zebrafish
Match: best4 (bestrophin 4 [Source:ZFIN;Acc:ZDB-GENE-070912-6])

HSP 1 Score: 202.601 bits (514), Expect = 5.263e-61
Identity = 118/335 (35.22%), Postives = 194/335 (57.91%), Query Frame = 1 
Query:   55 MSTSYFGK--HGRKNDYFKLLLRWDGSIYKILYXXXXXXXXXXXXXXXXNKNLLSEINQKYFSKFCEYCLYLSETIPIAFVLTFFVPLVVSRRFEQFKMIPWIDKMAIYLSAFLQGRTDDIVIKRRTVIRYMILSMTLCFRSISMPVMDAFESDEQLINAGLATQEEIVKIDSIPFSYNRYFVPLIWAGDIIHRADKHGLISGERCLALLLNEVMSFHEELQSILFYDWISIPLVYTQVSTICTYAYFICTVFGGQILGVKMFINFKNSTKPANNVTINYDEITEYL-MYFPIFFVIQFVIYMGWLKVAESMINPYGYDDEDFQMVSLIERNLQI 1050
            M+ SY  K  + +   + KLL RW GSIYK+LY EF +F  +Y  I+++ + +L+   Q+ F++   +C   ++ IP++FVL F+V     R + Q+   P  D + + +S  + G  +   + RRT++RY  LS  L  RSIS  V   F + E ++ AG  T +E+ K++ +   +N+Y++PL W  ++  +A K G +  +  L LL++E+ ++  +   +  YDWISIPLVYTQV T+  Y++F  ++ G Q +            KPA++         E+L +Y PIF +++F  Y GWLKV E +INP+G DD+DF+   LI+RN+Q+
Sbjct:    1 MTVSYTLKVANAKFGGFSKLLFRWKGSIYKLLYREFLVFCLLYTFISILYRCVLNNNQQEIFARLARHCNKFAKLIPMSFVLGFYVTQAFQRWWGQYTSFPLPDNLMMVVSGNVHGTDERGRLLRRTLMRYANLSSVLILRSISTRVRKRFTTLEDIVEAGFMTTDELRKLNHLYSDFNKYWMPLAWFANLASQARKEGRVKDDIALRLLMDELNNYRSKCSMLFHYDWISIPLVYTQVVTVAVYSFFTFSLIGRQFV------------KPASS--------EEHLDLYIPIFTLLEFFFYAGWLKVGELIINPFGEDDDDFETNQLIDRNIQV 315
[Close]
BLAST of Bestrophin homolog vs. Ensembl Zebrafish
Match: best1 (bestrophin 1 [Source:ZFIN;Acc:ZDB-GENE-110411-214])

HSP 1 Score: 134.806 bits (338), Expect = 1.829e-35
Identity = 67/191 (35.08%), Postives = 108/191 (56.54%), Query Frame = 1 
Query:  532 LATQEEIVKIDSIPFSYNRYFVPLIWAGDIIHRADKHGLISGERCLALLLNEVMSFHEELQSILFYDWISIPLVYTQVSTICTYAYFICTVFGGQILGVKMFINFKNSTKPANNVTINYDEITEYLMYFPIFFVIQFVIYMGWLKVAESMINPYGYDDEDFQMVSLIERNLQIGFVIVDKINNFPPKVTED 1104
            L T EE+ ++  +P  +N+++VP +W   +  RA   G I+ +  +  +LNE+ +   +   +  YDWIS+PLVYTQV T+  Y++F+  + G Q L             P +N+            Y P+F ++QF  Y+GWLKVAE +INP+G DD+DF+   L++RNLQ+  + VD++ +  P V  D
Sbjct:    2 LMTAEELRQLQELPSPHNKFWVPCMWFVSLAMRARSEGRINNDVAMTAILNELNTLRSQCMRLYGYDWISLPLVYTQVVTVAVYSFFLTCLIGRQFLDPAQ-------GYPGHNLDF----------YLPVFTLLQFFFYVGWLKVAEQLINPFGEDDDDFETNWLVDRNLQVSLLSVDEMYDLVPLVERD 175
[Close]
BLAST of Bestrophin homolog vs. Ensembl Xenopus
Match: best1 (bestrophin 1 [Source:NCBI gene;Acc:100302038])

HSP 1 Score: 228.409 bits (581), Expect = 4.151e-70
Identity = 141/392 (35.97%), Postives = 219/392 (55.87%), Query Frame = 1 
Query:   82 GRKNDYFKLLLRWDGSIYKILYXXXXXXXXXXXXXXXXNKNLLSEINQKYFSKFCEYCLYLSETIPIAFVLTFFVPLVVSRRFEQFKMIPWIDKMAIYLSAFLQGRTDDIVIKRRTVIRYMILSMTLCFRSISMPVMDAFESDEQLINAGLATQEEIVKIDSIPFSYNRYFVPLIWAGDIIHRADKHGLISGERCLALLLNEVMSFHEELQSILFYDWISIPLVYTQVSTICTYAYFICTVFGGQILGVKMFINFKNSTKPANNVTINYDEITEYLMYFPIFFVIQFVIYMGWLKVAESMINPYGYDDEDFQMVSLIERNLQIGFVIVDKINNFPPKVTEDVVPIYIKPNFNTLQMDKELFQNSQGMVDDDNAEFLEKSTVMYRKNLLFGSN 1257
             R   + +LLLRW GSIYK+LY EF IFI+ Y+II+V  + LL+E  + YF K   YC   +E IP++FVL F+V LVVSR + Q++ +PW D++   +S+ + G  +   + RRT++RY  L+  L  RS+S  V   F + + ++NAG  T  E  K D +  S+N+++VP +W  ++   A   G I     L L+L E+ S   +   +  YDWIS+PLVYTQV T+  Y++F+  + G Q L  +          P +++           +Y P+F ++QF  Y GWLKVAE +INP+G DD+DF+   LI+RNLQ+  + VD+++       +DV P           ++K+++ N         A  +E     Y+ +LL G+N
Sbjct:   12 ARLGTFSRLLLRWRGSIYKLLYREFLIFISCYFIISVTYRFLLNEQQRIYFEKLALYCDNYAELIPVSFVLGFYVTLVVSRWWGQYESVPWPDRLMCLVSSNVHGTDERGRMLRRTLMRYANLTGLLILRSVSTAVYMRFPTLQHVVNAGFMTPTERSKFDGLVSSHNKFWVPCVWFANLAVTARSEGRIRDNVVLQLILKELNSLRTQCGRLYGYDWISVPLVYTQVVTVAVYSFFLACLIGRQFLDPQ-------KGYPGHDMD----------LYVPVFTLLQFFFYAGWLKVAEQLINPFGQDDDDFETNWLIDRNLQVSLLAVDEMH-------QDVPP-----------LEKDIYWNDSDPQPPYTASTVETRRPSYQGSLLSGNN 368
[Close]
BLAST of Bestrophin homolog vs. Ensembl Xenopus
Match: best1 (bestrophin 1 [Source:NCBI gene;Acc:100302038])

HSP 1 Score: 226.483 bits (576), Expect = 3.056e-69
Identity = 133/353 (37.68%), Postives = 206/353 (58.36%), Query Frame = 1 
Query:   55 MSTSYFGK--HGRKNDYFKLLLRWDGSIYKILYXXXXXXXXXXXXXXXXNKNLLSEINQKYFSKFCEYCLYLSETIPIAFVLTFFVPLVVSRRFEQFKMIPWIDKMAIYLSAFLQGRTDDIVIKRRTVIRYMILSMTLCFRSISMPVMDAFESDEQLINAGLATQEEIVKIDSIPFSYNRYFVPLIWAGDIIHRADKHGLISGERCLALLLNEVMSFHEELQSILFYDWISIPLVYTQVSTICTYAYFICTVFGGQILGVKMFINFKNSTKPANNVTINYDEITEYLMYFPIFFVIQFVIYMGWLKVAESMINPYGYDDEDFQMVSLIERNLQIGFVIVDKINNFPPKVTEDV 1107
            M+ +Y  +    R   + +LLLRW GSIYK+LY EF IFI+ Y+II+V  + LL+E  + YF K   YC   +E IP++FVL F+V LVVSR + Q++ +PW D++   +S+ + G  +   + RRT++RY  L+  L  RS+S  V   F + + ++NAG  T  E  K D +  S+N+++VP +W  ++   A   G I     L L+L E+ S   +   +  YDWIS+PLVYTQV T+  Y++F+  + G Q L             P +++           +Y P+F ++QF  Y GWLKVAE +INP+G DD+DF+   LI+RNLQ+  + VD+++   P + +D+
Sbjct:    1 MTVTYSNRVADARLGTFSRLLLRWRGSIYKLLYREFLIFISCYFIISVTYRFLLNEQQRIYFEKLALYCDNYAELIPVSFVLGFYVTLVVSRWWGQYESVPWPDRLMCLVSSNVHGTDERGRMLRRTLMRYANLTGLLILRSVSTAVYMRFPTLQHVVNAGFMTPTERSKFDGLVSSHNKFWVPCVWFANLAVTARSEGRIRDNVVLQLILKELNSLRTQCGRLYGYDWISVPLVYTQVVTVAVYSFFLACLIGRQFLD-------PQKGYPGHDMD----------LYVPVFTLLQFFFYAGWLKVAEQLINPFGQDDDDFETNWLIDRNLQVSLLAVDEMHQDVPPLEKDI 336
[Close]
BLAST of Bestrophin homolog vs. Ensembl Xenopus
Match: best1 (bestrophin 1 [Source:NCBI gene;Acc:100302038])

HSP 1 Score: 226.098 bits (575), Expect = 8.274e-69
Identity = 133/353 (37.68%), Postives = 206/353 (58.36%), Query Frame = 1 
Query:   55 MSTSYFGK--HGRKNDYFKLLLRWDGSIYKILYXXXXXXXXXXXXXXXXNKNLLSEINQKYFSKFCEYCLYLSETIPIAFVLTFFVPLVVSRRFEQFKMIPWIDKMAIYLSAFLQGRTDDIVIKRRTVIRYMILSMTLCFRSISMPVMDAFESDEQLINAGLATQEEIVKIDSIPFSYNRYFVPLIWAGDIIHRADKHGLISGERCLALLLNEVMSFHEELQSILFYDWISIPLVYTQVSTICTYAYFICTVFGGQILGVKMFINFKNSTKPANNVTINYDEITEYLMYFPIFFVIQFVIYMGWLKVAESMINPYGYDDEDFQMVSLIERNLQIGFVIVDKINNFPPKVTEDV 1107
            M+ +Y  +    R   + +LLLRW GSIYK+LY EF IFI+ Y+II+V  + LL+E  + YF K   YC   +E IP++FVL F+V LVVSR + Q++ +PW D++   +S+ + G  +   + RRT++RY  L+  L  RS+S  V   F + + ++NAG  T  E  K D +  S+N+++VP +W  ++   A   G I     L L+L E+ S   +   +  YDWIS+PLVYTQV T+  Y++F+  + G Q L             P +++           +Y P+F ++QF  Y GWLKVAE +INP+G DD+DF+   LI+RNLQ+  + VD+++   P + +D+
Sbjct:    1 MTVTYSNRVADARLGTFSRLLLRWRGSIYKLLYREFLIFISCYFIISVTYRFLLNEQQRIYFEKLALYCDNYAELIPVSFVLGFYVTLVVSRWWGQYESVPWPDRLMCLVSSNVHGTDERGRMLRRTLMRYANLTGLLILRSVSTAVYMRFPTLQHVVNAGFMTPTERSKFDGLVSSHNKFWVPCVWFANLAVTARSEGRIRDNVVLQLILKELNSLRTQCGRLYGYDWISVPLVYTQVVTVAVYSFFLACLIGRQFLD-------PQKGYPGHDMD----------LYVPVFTLLQFFFYAGWLKVAEQLINPFGQDDDDFETNWLIDRNLQVSLLAVDEMHQDVPPLEKDI 336
[Close]
BLAST of Bestrophin homolog vs. Ensembl Xenopus
Match: best1 (bestrophin 1 [Source:NCBI gene;Acc:100302038])

HSP 1 Score: 226.868 bits (577), Expect = 1.133e-68
Identity = 131/342 (38.30%), Postives = 201/342 (58.77%), Query Frame = 1 
Query:   82 GRKNDYFKLLLRWDGSIYKILYXXXXXXXXXXXXXXXXNKNLLSEINQKYFSKFCEYCLYLSETIPIAFVLTFFVPLVVSRRFEQFKMIPWIDKMAIYLSAFLQGRTDDIVIKRRTVIRYMILSMTLCFRSISMPVMDAFESDEQLINAGLATQEEIVKIDSIPFSYNRYFVPLIWAGDIIHRADKHGLISGERCLALLLNEVMSFHEELQSILFYDWISIPLVYTQVSTICTYAYFICTVFGGQILGVKMFINFKNSTKPANNVTINYDEITEYLMYFPIFFVIQFVIYMGWLKVAESMINPYGYDDEDFQMVSLIERNLQIGFVIVDKINNFPPKVTEDV 1107
             R   + +LLLRW GSIYK+LY EF IFI+ Y+II+V  + LL+E  + YF K   YC   +E IP++FVL F+V LVVSR + Q++ +PW D++   +S+ + G  +   + RRT++RY  L+  L  RS+S  V   F + + ++NAG  T  E  K D +  S+N+++VP +W  ++   A   G I     L L+L E+ S   +   +  YDWIS+PLVYTQV T+  Y++F+  + G Q L             P +++           +Y P+F ++QF  Y GWLKVAE +INP+G DD+DF+   LI+RNLQ+  + VD+++   P + +D+
Sbjct:   12 ARLGTFSRLLLRWRGSIYKLLYREFLIFISCYFIISVTYRFLLNEQQRIYFEKLALYCDNYAELIPVSFVLGFYVTLVVSRWWGQYESVPWPDRLMCLVSSNVHGTDERGRMLRRTLMRYANLTGLLILRSVSTAVYMRFPTLQHVVNAGFMTPTERSKFDGLVSSHNKFWVPCVWFANLAVTARSEGRIRDNVVLQLILKELNSLRTQCGRLYGYDWISVPLVYTQVVTVAVYSFFLACLIGRQFLD-------PQKGYPGHDMD----------LYVPVFTLLQFFFYAGWLKVAEQLINPFGQDDDDFETNWLIDRNLQVSLLAVDEMHQDVPPLEKDI 336
[Close]
BLAST of Bestrophin homolog vs. Ensembl Xenopus
Match: ifitm3 (interferon induced transmembrane protein 3 [Source:Xenbase;Acc:XB-GENE-5852510])

HSP 1 Score: 229.565 bits (584), Expect = 1.021e-67
Identity = 132/364 (36.26%), Postives = 210/364 (57.69%), Query Frame = 1 
Query:   16 ISYSSKL*NFNCNMSTSYFGKHGRKNDYFKLLLRWDGSIYKILYXXXXXXXXXXXXXXXXNKNLLSEINQKYFSKFCEYCLYLSETIPIAFVLTFFVPLVVSRRFEQFKMIPWIDKMAIYLSAFLQGRTDDIVIKRRTVIRYMILSMTLCFRSISMPVMDAFESDEQLINAGLATQEEIVKIDSIPFSYNRYFVPLIWAGDIIHRADKHGLISGERCLALLLNEVMSFHEELQSILFYDWISIPLVYTQVSTICTYAYFICTVFGGQILGVKMFINFKNSTKPANNVTINYDEITEYLMYFPIFFVIQFVIYMGWLKVAESMINPYGYDDEDFQMVSLIERNLQIGFVIVDKINNFPPKVTEDV 1107
            ++YSSK+ N       ++FG H       +LLL+W GSIYK+LY EF +F ++Y  ++V+ +  L++  ++YF K   YC   +E IP+ FVL F+V LVV+R + QF  +PW D++   +S+ + GR +   + RRT++RY+ L+  L FRS+S  V   F + + ++ AG  T +E    DS+   + +Y+VP+IW G++  +A   G I     L +++NE+  F      +  YDW+ IPLVYTQV T+  Y +F   + G Q L  K          P +++           +Y P+F ++QF  Y GWLKVAE +INP+G DD+DF+    I+RNLQ+  + VD+++   PK+  D+
Sbjct:    3 VTYSSKVAN------ATFFGFH-------RLLLKWRGSIYKLLYREFLLFTSLYTTLSVIYRFFLTDSQKRYFEKVSMYCDKYAEQIPVTFVLGFYVTLVVNRWWNQFVNLPWPDRLMFLISSNVHGRDEYGRLLRRTLMRYVNLTSLLIFRSVSTAVYKRFPTMDHVVEAGFMTSDERKLFDSLKSPHLKYWVPVIWFGNLASKARSEGRIRDSIDLQMMMNEMNKFRSWCSLLFGYDWVGIPLVYTQVVTLAVYTFFFACIIGRQFLDPKQ-------AYPGHDLD----------LYIPVFTLLQFFFYAGWLKVAEQLINPFGEDDDDFETNWCIDRNLQVSLMAVDEMHMNLPKMNRDI 336
[Close]
BLAST of Bestrophin homolog vs. Ensembl Mouse
Match: Best1 (bestrophin 1 [Source:MGI Symbol;Acc:MGI:1346332])

HSP 1 Score: 226.483 bits (576), Expect = 4.828e-69
Identity = 146/426 (34.27%), Postives = 225/426 (52.82%), Query Frame = 1 
Query:   55 MSTSYFGK--HGRKNDYFKLLLRWDGSIYKILYXXXXXXXXXXXXXXXXNKNLLSEINQKYFSKFCEYCLYLSETIPIAFVLTFFVPLVVSRRFEQFKMIPWIDKMAIYLSAFLQGRTDDIVIKRRTVIRYMILSMTLCFRSISMPVMDAFESDEQLINAGLATQEEIVKIDSIPFSYNRYFVPLIWAGDIIHRADKHGLISGERCLALLLNEVMSFHEELQSILFYDWISIPLVYTQVSTICTYAYFICTVFGGQILGVKMFINFKNSTKPANNVTINYDEITEYLMYFPIFFVIQFVIYMGWLKVAESMINPYGYDDEDFQMVSLIERNLQIGFVIVDKIN-NFPPKVTEDVVPIYIKPNFNTLQMDKELFQNSQGMVDDDNAEFLEKSTVMYRKNLLFGSNI-----MDDINIIGTEEQNSDK 1308
            M+ +Y  K  + R   +  LLL W GSIYK+LY EF +FI +YY I  + + +LS   Q  F K   YC    + IPI+FVL F+V LVVSR + Q++ +PW D++ I +S+F++G+ ++  + RRT+IRY IL   L  RSIS  V   F +   L+ AG  T  E  ++  +   +N ++VP +W  ++  +A   G I     L  L+NEV +   +   +  YDWISIPLVYTQV T+  Y++F+  + G Q L         N   P +          E  +  P+F ++QF+ YMGWLKVAE +INP+G DD+DF+   +I+RNLQ+  + VD ++ N PP                   M+++++ N         A     ++   R++   GS        +D+ +   EE ++DK
Sbjct:    1 MTITYTNKVANARLGSFSSLLLCWRGSIYKLLYGEFLVFIFLYYSIRGLYRMVLSSDQQLLFEKLALYCDSYIQLIPISFVLGFYVTLVVSRWWSQYENLPWPDRLMIQVSSFVEGKDEEGRLLRRTLIRYAILGQVLILRSISTSVYKRFPTLHHLVLAGFMTHGEHKQLQKLGLPHNTFWVPWVWFANLSMKAYLGGRIRDTVLLQSLMNEVCTLRTQCGQLYAYDWISIPLVYTQVVTVAVYSFFLACLIGRQFLN-------PNKDYPGH----------EMDLVVPVFTILQFLFYMGWLKVAEQLINPFGEDDDDFETNWIIDRNLQVSLLSVDGMHQNLPP-------------------MERDMYWNEAAPQPPYTA-----ASARSRRHSFMGSTFNISLKKEDLELWSKEEADTDK 385
[Close]
BLAST of Bestrophin homolog vs. Ensembl Mouse
Match: Best1 (bestrophin 1 [Source:MGI Symbol;Acc:MGI:1346332])

HSP 1 Score: 224.942 bits (572), Expect = 4.538e-67
Identity = 146/426 (34.27%), Postives = 225/426 (52.82%), Query Frame = 1 
Query:   55 MSTSYFGK--HGRKNDYFKLLLRWDGSIYKILYXXXXXXXXXXXXXXXXNKNLLSEINQKYFSKFCEYCLYLSETIPIAFVLTFFVPLVVSRRFEQFKMIPWIDKMAIYLSAFLQGRTDDIVIKRRTVIRYMILSMTLCFRSISMPVMDAFESDEQLINAGLATQEEIVKIDSIPFSYNRYFVPLIWAGDIIHRADKHGLISGERCLALLLNEVMSFHEELQSILFYDWISIPLVYTQVSTICTYAYFICTVFGGQILGVKMFINFKNSTKPANNVTINYDEITEYLMYFPIFFVIQFVIYMGWLKVAESMINPYGYDDEDFQMVSLIERNLQIGFVIVDKIN-NFPPKVTEDVVPIYIKPNFNTLQMDKELFQNSQGMVDDDNAEFLEKSTVMYRKNLLFGSNI-----MDDINIIGTEEQNSDK 1308
            M+ +Y  K  + R   +  LLL W GSIYK+LY EF +FI +YY I  + + +LS   Q  F K   YC    + IPI+FVL F+V LVVSR + Q++ +PW D++ I +S+F++G+ ++  + RRT+IRY IL   L  RSIS  V   F +   L+ AG  T  E  ++  +   +N ++VP +W  ++  +A   G I     L  L+NEV +   +   +  YDWISIPLVYTQV T+  Y++F+  + G Q L         N   P +          E  +  P+F ++QF+ YMGWLKVAE +INP+G DD+DF+   +I+RNLQ+  + VD ++ N PP                   M+++++ N         A     ++   R++   GS        +D+ +   EE ++DK
Sbjct:    1 MTITYTNKVANARLGSFSSLLLCWRGSIYKLLYGEFLVFIFLYYSIRGLYRMVLSSDQQLLFEKLALYCDSYIQLIPISFVLGFYVTLVVSRWWSQYENLPWPDRLMIQVSSFVEGKDEEGRLLRRTLIRYAILGQVLILRSISTSVYKRFPTLHHLVLAGFMTHGEHKQLQKLGLPHNTFWVPWVWFANLSMKAYLGGRIRDTVLLQSLMNEVCTLRTQCGQLYAYDWISIPLVYTQVVTVAVYSFFLACLIGRQFLN-------PNKDYPGH----------EMDLVVPVFTILQFLFYMGWLKVAEQLINPFGEDDDDFETNWIIDRNLQVSLLSVDGMHQNLPP-------------------MERDMYWNEAAPQPPYTA-----ASARSRRHSFMGSTFNISLKKEDLELWSKEEADTDK 385
[Close]
BLAST of Bestrophin homolog vs. Ensembl Mouse
Match: Best2 (bestrophin 2 [Source:MGI Symbol;Acc:MGI:2387588])

HSP 1 Score: 221.476 bits (563), Expect = 3.827e-66
Identity = 130/342 (38.01%), Postives = 193/342 (56.43%), Query Frame = 1 
Query:   55 MSTSYFGK--HGRKNDYFKLLLRWDGSIYKILYXXXXXXXXXXXXXXXXNKNLLSEINQKYFSKFCEYCLYLSETIPIAFVLTFFVPLVVSRRFEQFKMIPWIDKMAIYLSAFLQGRTDDIVIKRRTVIRYMILSMTLCFRSISMPVMDAFESDEQLINAGLATQEEIVKIDSIPFSYNRYFVPLIWAGDIIHRADKHGLISGERCLALLLNEVMSFHEELQSILFYDWISIPLVYTQVSTICTYAYFICTVFGGQILGVKMFINFKNSTKPANNVTINYDEITEYLMYFPIFFVIQFVIYMGWLKVAESMINPYGYDDEDFQMVSLIERNLQIGFVIVDKI 1074
            M+ +Y  +  + R   + +LLL W GSIYK+L+ E   F+ +Y  ++   + LL+E  ++YF K   YC   +  IP++FVL F+V LVV R + Q+  +P  D +   ++  + GR D   + RRT++RY  LS  L  RS+S  V   F + + ++ AG  T+EE  K +++  SYN+Y+VP +W   +  +A + G I     L LLL E+  F  +   +  YDWISIPLVYTQV TI  Y+YF+  + G Q L             PA      Y + T  L   PIF ++QF  Y GWLKVAE +INP+G DD+DF+   LI+RN Q+  + VD++
Sbjct:    1 MTVTYTARVANARFGGFSQLLLLWRGSIYKLLWRELLCFLGLYMALSAAYRFLLAEEQKRYFEKLVIYCDQYASLIPVSFVLGFYVTLVVHRWWNQYLCMPLPDALMCIVAGTVHGRDDRGRLYRRTLMRYAGLSAVLILRSVSTAVFKRFPTIDHVVEAGFMTREERKKFENLNSSYNKYWVPCVWFSSLAAQARREGRIRDNSALKLLLEELNVFRSKCGMLFHYDWISIPLVYTQVVTIAVYSYFLACLIGRQFL------------DPAQ----GYKDHTLDLC-VPIFTLLQFFFYAGWLKVAEQLINPFGEDDDDFETNFLIDRNFQVSMLAVDEM 325
[Close]
BLAST of Bestrophin homolog vs. Ensembl Mouse
Match: Best2 (bestrophin 2 [Source:MGI Symbol;Acc:MGI:2387588])

HSP 1 Score: 221.476 bits (563), Expect = 3.827e-66
Identity = 130/342 (38.01%), Postives = 193/342 (56.43%), Query Frame = 1 
Query:   55 MSTSYFGK--HGRKNDYFKLLLRWDGSIYKILYXXXXXXXXXXXXXXXXNKNLLSEINQKYFSKFCEYCLYLSETIPIAFVLTFFVPLVVSRRFEQFKMIPWIDKMAIYLSAFLQGRTDDIVIKRRTVIRYMILSMTLCFRSISMPVMDAFESDEQLINAGLATQEEIVKIDSIPFSYNRYFVPLIWAGDIIHRADKHGLISGERCLALLLNEVMSFHEELQSILFYDWISIPLVYTQVSTICTYAYFICTVFGGQILGVKMFINFKNSTKPANNVTINYDEITEYLMYFPIFFVIQFVIYMGWLKVAESMINPYGYDDEDFQMVSLIERNLQIGFVIVDKI 1074
            M+ +Y  +  + R   + +LLL W GSIYK+L+ E   F+ +Y  ++   + LL+E  ++YF K   YC   +  IP++FVL F+V LVV R + Q+  +P  D +   ++  + GR D   + RRT++RY  LS  L  RS+S  V   F + + ++ AG  T+EE  K +++  SYN+Y+VP +W   +  +A + G I     L LLL E+  F  +   +  YDWISIPLVYTQV TI  Y+YF+  + G Q L             PA      Y + T  L   PIF ++QF  Y GWLKVAE +INP+G DD+DF+   LI+RN Q+  + VD++
Sbjct:    1 MTVTYTARVANARFGGFSQLLLLWRGSIYKLLWRELLCFLGLYMALSAAYRFLLAEEQKRYFEKLVIYCDQYASLIPVSFVLGFYVTLVVHRWWNQYLCMPLPDALMCIVAGTVHGRDDRGRLYRRTLMRYAGLSAVLILRSVSTAVFKRFPTIDHVVEAGFMTREERKKFENLNSSYNKYWVPCVWFSSLAAQARREGRIRDNSALKLLLEELNVFRSKCGMLFHYDWISIPLVYTQVVTIAVYSYFLACLIGRQFL------------DPAQ----GYKDHTLDLC-VPIFTLLQFFFYAGWLKVAEQLINPFGEDDDDFETNFLIDRNFQVSMLAVDEM 325
[Close]
BLAST of Bestrophin homolog vs. Ensembl Mouse
Match: Best2 (bestrophin 2 [Source:MGI Symbol;Acc:MGI:2387588])

HSP 1 Score: 221.476 bits (563), Expect = 3.827e-66
Identity = 130/342 (38.01%), Postives = 193/342 (56.43%), Query Frame = 1 
Query:   55 MSTSYFGK--HGRKNDYFKLLLRWDGSIYKILYXXXXXXXXXXXXXXXXNKNLLSEINQKYFSKFCEYCLYLSETIPIAFVLTFFVPLVVSRRFEQFKMIPWIDKMAIYLSAFLQGRTDDIVIKRRTVIRYMILSMTLCFRSISMPVMDAFESDEQLINAGLATQEEIVKIDSIPFSYNRYFVPLIWAGDIIHRADKHGLISGERCLALLLNEVMSFHEELQSILFYDWISIPLVYTQVSTICTYAYFICTVFGGQILGVKMFINFKNSTKPANNVTINYDEITEYLMYFPIFFVIQFVIYMGWLKVAESMINPYGYDDEDFQMVSLIERNLQIGFVIVDKI 1074
            M+ +Y  +  + R   + +LLL W GSIYK+L+ E   F+ +Y  ++   + LL+E  ++YF K   YC   +  IP++FVL F+V LVV R + Q+  +P  D +   ++  + GR D   + RRT++RY  LS  L  RS+S  V   F + + ++ AG  T+EE  K +++  SYN+Y+VP +W   +  +A + G I     L LLL E+  F  +   +  YDWISIPLVYTQV TI  Y+YF+  + G Q L             PA      Y + T  L   PIF ++QF  Y GWLKVAE +INP+G DD+DF+   LI+RN Q+  + VD++
Sbjct:    1 MTVTYTARVANARFGGFSQLLLLWRGSIYKLLWRELLCFLGLYMALSAAYRFLLAEEQKRYFEKLVIYCDQYASLIPVSFVLGFYVTLVVHRWWNQYLCMPLPDALMCIVAGTVHGRDDRGRLYRRTLMRYAGLSAVLILRSVSTAVFKRFPTIDHVVEAGFMTREERKKFENLNSSYNKYWVPCVWFSSLAAQARREGRIRDNSALKLLLEELNVFRSKCGMLFHYDWISIPLVYTQVVTIAVYSYFLACLIGRQFL------------DPAQ----GYKDHTLDLC-VPIFTLLQFFFYAGWLKVAEQLINPFGEDDDDFETNFLIDRNFQVSMLAVDEM 325
[Close]
BLAST of Bestrophin homolog vs. UniProt/SwissProt
Match: sp|Q8NFU0|BEST4_HUMAN (Bestrophin-4 OS=Homo sapiens OX=9606 GN=BEST4 PE=2 SV=1)

HSP 1 Score: 224.172 bits (570), Expect = 1.122e-66
Identity = 133/353 (37.68%), Postives = 206/353 (58.36%), Query Frame = 1 
Query:   55 MSTSYFGK--HGRKNDYFKLLLRWDGSIYKILYXXXXXXXXXXXXXXXXNKNLLSEINQKYFSKFCEYCLYLSETIPIAFVLTFFVPLVVSRRFEQFKMIPWIDKMAIYLSAFLQGRTDDIVIKRRTVIRYMILSMTLCFRSISMPVMDAFESDEQLINAGLATQEEIVKIDSIPFSYNRYFVPLIWAGDIIHRADKHGLISGERCLALLLNEVMSFHEELQSILFYDWISIPLVYTQVSTICTYAYFICTVFGGQIL-----GVKMFINFKNSTKPANNVTINYDEITEYLMYFPIFFVIQFVIYMGWLKVAESMINPYGYDDEDFQMVSLIERNLQIGFVIVDKI-NNFPP 1089
            M+ SY  K    R   +  LLLRW GSIYK+LY EF +F A+Y ++++  + LL++  +  +++   YC   ++ IP++FVL F+V LVV+R + Q+  IP  D++   +SA + G      + RRT+IRY  L+  L  RS+S  V+  F + E +++AG  +QEE  K +S+   +N+Y+VP +W  ++  +A + G I  +  L LLL E+  +  +   +  YDWISIPLVYTQV TI  Y++F  ++ G Q +       K     K   +PA         + +  MY P+  ++QF  Y GWLKVAE +INP+G DD+DF+   LI+RNLQ+  + VD++  N PP
Sbjct:    1 MTVSYTLKVAEARFGGFSGLLLRWRGSIYKLLYKEFLLFGALYAVLSITYRLLLTQEQRYVYAQVARYCNRSADLIPLSFVLGFYVTLVVNRWWSQYTSIPLPDQLMCVISASVHGVDQRGRLLRRTLIRYANLASVLVLRSVSTRVLKRFPTMEHVVDAGFMSQEERKKFESLKSDFNKYWVPCVWFTNLAAQARRDGRIRDDIALCLLLEELNKYRAKCSMLFHYDWISIPLVYTQVVTIAVYSFFALSLVGRQFVEPEAGAAKPQKLLKPGQEPA-------PALGDPDMYVPLTTLLQFFFYAGWLKVAEQIINPFGEDDDDFETNQLIDRNLQVSLLSVDEMYQNLPP 346
[Close]
BLAST of Bestrophin homolog vs. UniProt/SwissProt
Match: sp|O88870|BEST1_MOUSE (Bestrophin-1 OS=Mus musculus OX=10090 GN=Best1 PE=2 SV=3)

HSP 1 Score: 224.942 bits (572), Expect = 3.174e-66
Identity = 146/426 (34.27%), Postives = 225/426 (52.82%), Query Frame = 1 
Query:   55 MSTSYFGK--HGRKNDYFKLLLRWDGSIYKILYXXXXXXXXXXXXXXXXNKNLLSEINQKYFSKFCEYCLYLSETIPIAFVLTFFVPLVVSRRFEQFKMIPWIDKMAIYLSAFLQGRTDDIVIKRRTVIRYMILSMTLCFRSISMPVMDAFESDEQLINAGLATQEEIVKIDSIPFSYNRYFVPLIWAGDIIHRADKHGLISGERCLALLLNEVMSFHEELQSILFYDWISIPLVYTQVSTICTYAYFICTVFGGQILGVKMFINFKNSTKPANNVTINYDEITEYLMYFPIFFVIQFVIYMGWLKVAESMINPYGYDDEDFQMVSLIERNLQIGFVIVDKIN-NFPPKVTEDVVPIYIKPNFNTLQMDKELFQNSQGMVDDDNAEFLEKSTVMYRKNLLFGSNI-----MDDINIIGTEEQNSDK 1308
            M+ +Y  K  + R   +  LLL W GSIYK+LY EF +FI +YY I  + + +LS   Q  F K   YC    + IPI+FVL F+V LVVSR + Q++ +PW D++ I +S+F++G+ ++  + RRT+IRY IL   L  RSIS  V   F +   L+ AG  T  E  ++  +   +N ++VP +W  ++  +A   G I     L  L+NEV +   +   +  YDWISIPLVYTQV T+  Y++F+  + G Q L         N   P +          E  +  P+F ++QF+ YMGWLKVAE +INP+G DD+DF+   +I+RNLQ+  + VD ++ N PP                   M+++++ N         A     ++   R++   GS        +D+ +   EE ++DK
Sbjct:    1 MTITYTNKVANARLGSFSSLLLCWRGSIYKLLYGEFLVFIFLYYSIRGLYRMVLSSDQQLLFEKLALYCDSYIQLIPISFVLGFYVTLVVSRWWSQYENLPWPDRLMIQVSSFVEGKDEEGRLLRRTLIRYAILGQVLILRSISTSVYKRFPTLHHLVLAGFMTHGEHKQLQKLGLPHNTFWVPWVWFANLSMKAYLGGRIRDTVLLQSLMNEVCTLRTQCGQLYAYDWISIPLVYTQVVTVAVYSFFLACLIGRQFLN-------PNKDYPGH----------EMDLVVPVFTILQFLFYMGWLKVAEQLINPFGEDDDDFETNWIIDRNLQVSLLSVDGMHQNLPP-------------------MERDMYWNEAAPQPPYTA-----ASARSRRHSFMGSTFNISLKKEDLELWSKEEADTDK 385
[Close]
BLAST of Bestrophin homolog vs. UniProt/SwissProt
Match: sp|Q8BGM5|BEST2_MOUSE (Bestrophin-2 OS=Mus musculus OX=10090 GN=Best2 PE=2 SV=1)

HSP 1 Score: 221.476 bits (563), Expect = 2.594e-65
Identity = 130/342 (38.01%), Postives = 193/342 (56.43%), Query Frame = 1 
Query:   55 MSTSYFGK--HGRKNDYFKLLLRWDGSIYKILYXXXXXXXXXXXXXXXXNKNLLSEINQKYFSKFCEYCLYLSETIPIAFVLTFFVPLVVSRRFEQFKMIPWIDKMAIYLSAFLQGRTDDIVIKRRTVIRYMILSMTLCFRSISMPVMDAFESDEQLINAGLATQEEIVKIDSIPFSYNRYFVPLIWAGDIIHRADKHGLISGERCLALLLNEVMSFHEELQSILFYDWISIPLVYTQVSTICTYAYFICTVFGGQILGVKMFINFKNSTKPANNVTINYDEITEYLMYFPIFFVIQFVIYMGWLKVAESMINPYGYDDEDFQMVSLIERNLQIGFVIVDKI 1074
            M+ +Y  +  + R   + +LLL W GSIYK+L+ E   F+ +Y  ++   + LL+E  ++YF K   YC   +  IP++FVL F+V LVV R + Q+  +P  D +   ++  + GR D   + RRT++RY  LS  L  RS+S  V   F + + ++ AG  T+EE  K +++  SYN+Y+VP +W   +  +A + G I     L LLL E+  F  +   +  YDWISIPLVYTQV TI  Y+YF+  + G Q L             PA      Y + T  L   PIF ++QF  Y GWLKVAE +INP+G DD+DF+   LI+RN Q+  + VD++
Sbjct:    1 MTVTYTARVANARFGGFSQLLLLWRGSIYKLLWRELLCFLGLYMALSAAYRFLLAEEQKRYFEKLVIYCDQYASLIPVSFVLGFYVTLVVHRWWNQYLCMPLPDALMCIVAGTVHGRDDRGRLYRRTLMRYAGLSAVLILRSVSTAVFKRFPTIDHVVEAGFMTREERKKFENLNSSYNKYWVPCVWFSSLAAQARREGRIRDNSALKLLLEELNVFRSKCGMLFHYDWISIPLVYTQVVTIAVYSYFLACLIGRQFL------------DPAQ----GYKDHTLDLC-VPIFTLLQFFFYAGWLKVAEQLINPFGEDDDDFETNFLIDRNFQVSMLAVDEM 325
[Close]
BLAST of Bestrophin homolog vs. UniProt/SwissProt
Match: sp|Q8NFU1|BEST2_HUMAN (Bestrophin-2 OS=Homo sapiens OX=9606 GN=BEST2 PE=1 SV=1)

HSP 1 Score: 218.779 bits (556), Expect = 3.283e-64
Identity = 125/342 (36.55%), Postives = 193/342 (56.43%), Query Frame = 1 
Query:   55 MSTSYFGK--HGRKNDYFKLLLRWDGSIYKILYXXXXXXXXXXXXXXXXNKNLLSEINQKYFSKFCEYCLYLSETIPIAFVLTFFVPLVVSRRFEQFKMIPWIDKMAIYLSAFLQGRTDDIVIKRRTVIRYMILSMTLCFRSISMPVMDAFESDEQLINAGLATQEEIVKIDSIPFSYNRYFVPLIWAGDIIHRADKHGLISGERCLALLLNEVMSFHEELQSILFYDWISIPLVYTQVSTICTYAYFICTVFGGQILGVKMFINFKNSTKPANNVTINYDEITEYLMYFPIFFVIQFVIYMGWLKVAESMINPYGYDDEDFQMVSLIERNLQIGFVIVDKI 1074
            M+ +Y  +  + R   + +LLL W GSIYK+L+ E   F+  Y  ++   + +L+E  ++YF K   YC   +  IP++FVL F+V LVV+R + Q+  +P  D +   ++  + GR D   + RRT++RY  LS  L  RS+S  V   F + + ++ AG  T+EE  K +++  SYN+Y+VP +W  ++  +A + G I     L LLL E+  F  +   +  YDWIS+PLVYTQV TI  Y+YF+  + G Q L             PA     +     +  +  PIF ++QF  Y GWLKVAE +INP+G DD+DF+   LI+RN Q+  + VD++
Sbjct:    1 MTVTYTARVANARFGGFSQLLLLWRGSIYKLLWRELLCFLGFYMALSAAYRFVLTEGQKRYFEKLVIYCDQYASLIPVSFVLGFYVTLVVNRWWSQYLCMPLPDALMCVVAGTVHGRDDRGRLYRRTLMRYAGLSAVLILRSVSTAVFKRFPTIDHVVEAGFMTREERKKFENLNSSYNKYWVPCVWFSNLAAQARREGRIRDNSALKLLLEELNVFRGKCGMLFHYDWISVPLVYTQVVTIALYSYFLACLIGRQFL------------DPAQGYKDH-----DLDLCVPIFTLLQFFFYAGWLKVAEQLINPFGEDDDDFETNFLIDRNFQVSMLAVDEM 325
[Close]
BLAST of Bestrophin homolog vs. UniProt/SwissProt
Match: sp|Q6H1V1|BEST3_MOUSE (Bestrophin-3 OS=Mus musculus OX=10090 GN=Best3 PE=2 SV=1)

HSP 1 Score: 219.55 bits (558), Expect = 3.439e-63
Identity = 134/364 (36.81%), Postives = 206/364 (56.59%), Query Frame = 1 
Query:   16 ISYSSKL*NFNCNMSTSYFGKHGRKNDYFKLLLRWDGSIYKILYXXXXXXXXXXXXXXXXNKNLLSEINQKYFSKFCEYCLYLSETIPIAFVLTFFVPLVVSRRFEQFKMIPWIDKMAIYLSAFLQGRTDDIVIKRRTVIRYMILSMTLCFRSISMPVMDAFESDEQLINAGLATQEEIVKIDSIPFSYNRYFVPLIWAGDIIHRADKHGLISGERCLALLLNEVMSFHEELQSILFYDWISIPLVYTQVSTICTYAYFICTVFGGQILGVKMFINFKNSTKPANNVTINYDEITEYLMYFPIFFVIQFVIYMGWLKVAESMINPYGYDDEDFQMVSLIERNLQIGFVIVDKINNFPPKVTEDV 1107
            ++YSSK+ N       ++FG H       +LLL+W GSIYK+LY EF +F  +Y  I++V + LL+   ++YF K   YC   +E IP+ FVL F+V LVV+R + QF  +PW D++ + +S+ + G      + RRT++RY+ L+  L FRS+S  V   F + + ++ AG  T +E    D +   + +Y+VP IW G++  +A   G I     L  L+ E+  +      +  YDW+ IPLVYTQV T+  Y +F   + G Q L         + TK    V  + D      +Y PIF ++QF  Y GWLKVAE +INP+G DD+DF+    I+RNLQ+  + VD+++   PK+ +D+
Sbjct:    3 VTYSSKVAN------ATFFGFH-------RLLLKWRGSIYKLLYREFIVFAVLYTAISLVYRLLLTGAQKRYFEKLSIYCDRYAEQIPVTFVLGFYVTLVVNRWWNQFVNLPWPDRLMLLISSSVHGSDQHGRLLRRTLMRYVNLTSLLIFRSVSTAVYKRFPTMDHVVEAGFMTADERKLFDHLKSPHLKYWVPFIWFGNLATKARNEGRIRDSVDLQSLMTEMNRYRSWCSLLFGYDWVGIPLVYTQVVTLAVYTFFFACLIGRQFL---------DPTK--GYVGHDLD------LYVPIFTLLQFFFYAGWLKVAEQLINPFGEDDDDFETNWCIDRNLQVSLLAVDEMHMSLPKMKKDI 336
[Close]
BLAST of Bestrophin homolog vs. TrEMBL
Match: A0A2R2ML91 (Bestrophin homolog OS=Lingula unguis OX=7574 GN=LOC112041682 PE=3 SV=1)

HSP 1 Score: 256.914 bits (655), Expect = 1.139e-76
Identity = 138/355 (38.87%), Postives = 219/355 (61.69%), Query Frame = 1 
Query:   40 NFNCNMSTSYFGKHGRKNDYFKLLLRWDGSIYKILYXXXXXXXXXXXXXXXXNKNLLSEINQKYFSKFCEYCLYLSETIPIAFVLTFFVPLVVSRRFEQFKMIPWIDKMAIYLSAFLQGRTDDIVIKRRTVIRYMILSMTLCFRSISMPVMDAFESDEQLINAGLATQEEIVKIDSIPFSYNRYFVPLIWAGDIIHRADKHGLISGERCLALLLNEVMSFHEELQSILFYDWISIPLVYTQVSTICTYAYFICTVFGGQILGVKMFINFKNSTKPANNVTINYDEITEYLMYFPIFFVIQFVIYMGWLKVAESMINPYGYDDEDFQMVSLIERNLQIGFVIVDKINNFPPKVTED 1104
             +   ++TS+FG       +++LLLRW GS+YK+L+ E  IF+  Y+ I+ + +  L E +++ F +   YC   +  IP+AFVL F+V +VV+R +E+F  IPW DKMA+Y++A + G  D   + RRT++RY+ LS  +  R+IS  V   F +D+ L  AGL T+ E   I+ +  + ++YFVPL+W   II RA K G I  +  +  L+ E+     +L  +L YDWI++PL+YTQV T+  Y +F+  + G Q L         +  +  +N  I++        Y PIF ++QF+ YMGWLKVAES++NP+G DD+DF+M  LI+RNLQ+ ++IVD++++  P + +D
Sbjct:    4 TYTAEVATSHFGT------FWRLLLRWKGSVYKLLWVELLIFVVAYFTISFIYRFALPENHKRTFERISIYCELYNNLIPMAFVLGFYVSIVVTRWWEEFMSIPWPDKMALYVTANIHGHDDRGRLIRRTIMRYICLSFVMTARAISTAVKKRFPTDDHLTEAGLQTENEQKIIEGVKTNNSKYFVPLVWTTSIISRARKEGRIRDDFAMKTLVEELNFVRGQLGGLLNYDWINVPLIYTQVVTMAVYTFFLSCLMGRQFL---------DPQQGYDNHQIDF--------YIPIFTILQFIFYMGWLKVAESLLNPFGEDDDDFEMNWLIDRNLQVAYLIVDEMHSEHPDLIKD 335
[Close]
BLAST of Bestrophin homolog vs. TrEMBL
Match: A0A1S3K2B3 (Bestrophin homolog OS=Lingula unguis OX=7574 GN=LOC106178213 PE=3 SV=1)

HSP 1 Score: 256.914 bits (655), Expect = 1.425e-76
Identity = 138/355 (38.87%), Postives = 219/355 (61.69%), Query Frame = 1 
Query:   40 NFNCNMSTSYFGKHGRKNDYFKLLLRWDGSIYKILYXXXXXXXXXXXXXXXXNKNLLSEINQKYFSKFCEYCLYLSETIPIAFVLTFFVPLVVSRRFEQFKMIPWIDKMAIYLSAFLQGRTDDIVIKRRTVIRYMILSMTLCFRSISMPVMDAFESDEQLINAGLATQEEIVKIDSIPFSYNRYFVPLIWAGDIIHRADKHGLISGERCLALLLNEVMSFHEELQSILFYDWISIPLVYTQVSTICTYAYFICTVFGGQILGVKMFINFKNSTKPANNVTINYDEITEYLMYFPIFFVIQFVIYMGWLKVAESMINPYGYDDEDFQMVSLIERNLQIGFVIVDKINNFPPKVTED 1104
             +   ++TS+FG       +++LLLRW GS+YK+L+ E  IF+  Y+ I+ + +  L E +++ F +   YC   +  IP+AFVL F+V +VV+R +E+F  IPW DKMA+Y++A + G  D   + RRT++RY+ LS  +  R+IS  V   F +D+ L  AGL T+ E   I+ +  + ++YFVPL+W   II RA K G I  +  +  L+ E+     +L  +L YDWI++PL+YTQV T+  Y +F+  + G Q L         +  +  +N  I++        Y PIF ++QF+ YMGWLKVAES++NP+G DD+DF+M  LI+RNLQ+ ++IVD++++  P + +D
Sbjct:    4 TYTAEVATSHFGT------FWRLLLRWKGSVYKLLWVELLIFVVAYFTISFIYRFALPENHKRTFERISIYCELYNNLIPMAFVLGFYVSIVVTRWWEEFMSIPWPDKMALYVTANIHGHDDRGRLIRRTIMRYICLSFVMTARAISTAVKKRFPTDDHLTEAGLQTENEQKIIEGVKTNNSKYFVPLVWTTSIISRARKEGRIRDDFAMKTLVEELNFVRGQLGGLLNYDWINVPLIYTQVVTMAVYTFFLSCLMGRQFL---------DPQQGYDNHQIDF--------YIPIFTILQFIFYMGWLKVAESLLNPFGEDDDDFEMNWLIDRNLQVAYLIVDEMHSEHPDLIKD 335
[Close]
BLAST of Bestrophin homolog vs. TrEMBL
Match: C1L441 (Bestrophin homolog OS=Schistosoma japonicum OX=6182 PE=2 SV=1)

HSP 1 Score: 243.817 bits (621), Expect = 1.856e-72
Identity = 132/338 (39.05%), Postives = 208/338 (61.54%), Query Frame = 1 
Query:   97 YFKLLLRWDGSIYKILYXXXXXXXXXXXXXXXXNKNLLSEINQKYFSKFCEYCLYLSETIPIAFVLTFFVPLVVSRRFEQFKMIPWIDKMAIYLSAFLQGRTDDIVIKRRTVIRYMILSMTLCFRSISMPVMDAFESDEQLINAGLATQEEI-VKIDSIPFSYNRYFVPLIWAGDIIHRADKHGLISGERCLALLLNEVMSFHEELQSILFYDWISIPLVYTQVSTICTYAYFICTVFGGQILGVKMFINFKNSTKPANNVTINYDEITEYLMYFPIFFVIQFVIYMGWLKVAESMINPYGYDDEDFQMVSLIERNLQIGFVIVDKINNFPPKVTEDV 1107
            + +LL  W GS+Y++++ EF +F+ IY +++V  + +LS   ++YF + C YC   +ET+P+AFVL F+V L+V R +EQF  +PW D++A++++AF  G  +     RR ++RY+ LS  +  R+IS      F ++E L++AGL TQEE+ +   + P  Y  YFVPL+WA D++ +A + G I  +R + +L +E+ SF  +L +I  YDW++ PLVYTQ  TI  Y YF   +   Q L             P+        E  E  +Y PIF +++F  Y+GWLKVAES+INP+G D +DF++  LIERNLQ+ ++IVD +++  P +  D 
Sbjct:   17 FIRLLFMWKGSVYRLVWFEFLVFVGIYSVLSVTYRFILSATLKRYFEQLCIYCGRYNETVPVAFVLGFYVSLIVQRWWEQFLSLPWPDRLALFITAFCHGNAERPTRIRRNIVRYINLSYCIALRAISSRARLRFPTEEHLVSAGLMTQEELDIYRSTQPSQYTLYFVPLVWALDMVTKAREEGYIHFDRAVEILTDEITSFRSKLGTIFAYDWVNPPLVYTQTVTIAVYGYFGTCLLAWQYL------------DPSKKY-----EGHEIDIYVPIFGLLRFFFYIGWLKVAESLINPFGEDVDDFEIEYLIERNLQVSYLIVDGMHHEHPDLVRDA 337
[Close]
BLAST of Bestrophin homolog vs. TrEMBL
Match: A0A3Q0KLS6 (Bestrophin homolog OS=Schistosoma mansoni OX=6183 PE=3 SV=1)

HSP 1 Score: 243.047 bits (619), Expect = 4.318e-72
Identity = 131/338 (38.76%), Postives = 208/338 (61.54%), Query Frame = 1 
Query:   97 YFKLLLRWDGSIYKILYXXXXXXXXXXXXXXXXNKNLLSEINQKYFSKFCEYCLYLSETIPIAFVLTFFVPLVVSRRFEQFKMIPWIDKMAIYLSAFLQGRTDDIVIKRRTVIRYMILSMTLCFRSISMPVMDAFESDEQLINAGLATQEEI-VKIDSIPFSYNRYFVPLIWAGDIIHRADKHGLISGERCLALLLNEVMSFHEELQSILFYDWISIPLVYTQVSTICTYAYFICTVFGGQILGVKMFINFKNSTKPANNVTINYDEITEYLMYFPIFFVIQFVIYMGWLKVAESMINPYGYDDEDFQMVSLIERNLQIGFVIVDKINNFPPKVTEDV 1107
            + +LL  W GS+Y++++ EF +F+ IY +++V  + +LS   ++YF   C YC   +ET+P+AFVL F+V L+V R +EQF  +PW D++A++++AF  G  +     RR ++RY+ LS  +  R+IS      F ++E L++AGL TQEE+ +   + P  Y  YFVPL+WA D++ +A + G I  +R + +L NE+ SF  +L +I  YDW++ PLVYTQ  TI  Y YF   +   Q L         + +K      ++        +Y PIF +++F  Y+GWLKVAES+INP+G D +DF++  LIERNLQ+ ++IVD +++  P +  D 
Sbjct:   17 FIRLLFMWKGSVYRLVWFEFLVFVGIYSVLSVTYRFILSATLKRYFELLCIYCGRYNETVPVAFVLGFYVSLIVQRWWEQFLALPWPDRLALFITAFCHGNAERPTRIRRNIVRYINLSYCIALRAISSRARLRFPTEEHLVSAGLMTQEELDIYRSTQPSEYTLYFVPLVWALDMVTKAREEGYIRFDRAVEILTNEITSFRGKLGTIFAYDWVNPPLVYTQTVTIAVYGYFGTCLLAWQYL---------DPSKKYEGHDVD--------IYVPIFGLLRFFFYIGWLKVAESLINPFGEDVDDFEIEYLIERNLQVSYLIVDGMHHEHPDLVRDA 337
[Close]
BLAST of Bestrophin homolog vs. TrEMBL
Match: A0A504Z0E6 (Bestrophin homolog OS=Fasciola gigantica OX=46835 GN=FGIG_05512 PE=3 SV=1)

HSP 1 Score: 239.965 bits (611), Expect = 5.631e-71
Identity = 131/340 (38.53%), Postives = 210/340 (61.76%), Query Frame = 1 
Query:   91 NDYFKLLLRWDGSIYKILYXXXXXXXXXXXXXXXXNKNLLSEINQKYFSKFCEYCLYLSETIPIAFVLTFFVPLVVSRRFEQFKMIPWIDKMAIYLSAFLQGRTDDIVIKRRTVIRYMILSMTLCFRSISMPVMDAFESDEQLINAGLATQEEI-VKIDSIPFSYNRYFVPLIWAGDIIHRADKHGLISGERCLALLLNEVMSFHEELQSILFYDWISIPLVYTQVSTICTYAYFICTVFGGQILGVKMFINFKNSTKPANNVTINYDEITEYLMYFPIFFVIQFVIYMGWLKVAESMINPYGYDDEDFQMVSLIERNLQIGFVIVDKINNFPPKVTEDV 1107
            + + +LL  W GS+Y++++ E  IF  IY I+++  + LL+ + + YF   C YC   +E IP+ FVL F+V LVV+R +EQF  +PW D++A+ ++A+  G  +     RRTV+RY  L+  +  R+IS      F + E L++AGL T+EE+ V + + P  Y  YFVPL+WA +I+ +A + G I  +R + +L  E+ SF  +L +I  YDWI+ PLVYTQ++TI  Y+YF+  +F  Q L +       +   P  ++ I          Y P+F +++F  Y+GWLKVAES+INP+G D +DF++  LIERNL + ++IVD++++  P++  D 
Sbjct:   15 STFLRLLFLWKGSVYRLIWFELLIFTGIYSILSLTYRFLLTGMMKTYFEWLCLYCNQHNEMIPVPFVLGFYVSLVVTRWWEQFLSLPWPDQLALQMTAYCHGNDERPTRIRRTVMRYTNLAYCIALRAISSRARLRFPTAEHLVSAGLMTEEELDVLVKTEPTEYQLYFVPLVWALNIVSQARQEGHIRFDRAVEILTEEITSFRGKLGTIFAYDWINPPLVYTQMATIVVYSYFLACLFAWQYLDL-------SKGYPGYDIDI----------YVPVFGLLRFFFYIGWLKVAESLINPFGEDADDFEIEYLIERNLNVSYLIVDEMHHEHPELVRDA 337
[Close]
BLAST of Bestrophin homolog vs. Ensembl Cavefish
Match: best1 (bestrophin-2 [Source:NCBI gene;Acc:103045999])

HSP 1 Score: 234.958 bits (598), Expect = 1.652e-69
Identity = 130/341 (38.12%), Postives = 205/341 (60.12%), Query Frame = 1 
Query:   82 GRKNDYFKLLLRWDGSIYKILYXXXXXXXXXXXXXXXXNKNLLSEINQKYFSKFCEYCLYLSETIPIAFVLTFFVPLVVSRRFEQFKMIPWIDKMAIYLSAFLQGRTDDIVIKRRTVIRYMILSMTLCFRSISMPVMDAFESDEQLINAGLATQEEIVKIDSIPFSYNRYFVPLIWAGDIIHRADKHGLISGERCLALLLNEVMSFHEELQSILFYDWISIPLVYTQVSTICTYAYFICTVFGGQILGVKMFINFKNSTKPANNVTINYDEITEYLMYFPIFFVIQFVIYMGWLKVAESMINPYGYDDEDFQMVSLIERNLQIGFVIVDKINNFPPKVTED 1104
             R   +  LLLRW GSIYK+LY E  IF  +Y  I+V+ + LL    ++ F K   YC   ++ IP++FVL F+V LVVSR + QF+ +PW D++A  + A+++G  +   + RR+++RY  LS  L +RSIS  V   F + E L+ AGL T EE  ++D +P  +N+++VP +W  ++  RA   G I+ +  L+ +LNE+ +   +   +  YDWIS+PLVYTQV T+  Y++F+  + G Q L         + T+  +   +++        Y P+F ++QF  Y+GWLKVAE +INP+G DD+DF+   L++RNLQ+  + VD++ +  P V  D
Sbjct:   12 ARLGTFSHLLLRWKGSIYKLLYRELLIFTVLYCTISVLYRFLLDNEQRRLFEKLAIYCDQYAQLIPVSFVLGFYVTLVVSRWWGQFESVPWPDRLAALVGAYVRGADEGARLIRRSLVRYANLSGVLIYRSISTAVYKRFPTIEHLVQAGLMTVEERRQLDDLPSPHNKFWVPCMWFVNLALRARTEGRINNDVALSAILNELNTLRSQCMKLYSYDWISLPLVYTQVVTVAVYSFFLACLIGRQFL---------DPTQGYSGHDLDF--------YLPVFTLLQFFFYVGWLKVAEQLINPFGEDDDDFETNWLVDRNLQVSLLSVDEMYDLVPLVERD 335
[Close]
BLAST of Bestrophin homolog vs. Ensembl Cavefish
Match: best2 (bestrophin 2 [Source:ZFIN;Acc:ZDB-GENE-090312-127])

HSP 1 Score: 209.92 bits (533), Expect = 1.116e-60
Identity = 123/342 (35.96%), Postives = 191/342 (55.85%), Query Frame = 1 
Query:   55 MSTSYFGK--HGRKNDYFKLLLRWDGSIYKILYXXXXXXXXXXXXXXXXNKNLLSEINQKYFSKFCEYCLYLSETIPIAFVLTFFVPLVVSRRFEQFKMIPWIDKMAIYLSAFLQGRTDDIVIKRRTVIRYMILSMTLCFRSISMPVMDAFESDEQLINAGLATQEEIVKIDSIPFSYNRYFVPLIWAGDIIHRADKHGLISGERCLALLLNEVMSFHEELQSILFYDWISIPLVYTQVSTICTYAYFICTVFGGQILGVKMFINFKNSTKPANNVTINYDEITEYLMYFPIFFVIQFVIYMGWLKVAESMINPYGYDDEDFQMVSLIERNLQIGFVIVDKI 1074
            M+ +Y  +  + R   + KLLL W GSIYK+LY E   F  +Y  I++  +  L +  ++YF K   YC + +  IP++FVL F+V L+V+R + Q+  IP  D +   LS  LQG  +   + RRT++RY  L+  L  RS+S  V   F + + ++ AG  T+EE  K +S+   YN+Y++P +W  ++   A   G I  +    LLL E+  F  +   +  YD IS+PLVYTQV T+  Y++F+  + G Q L         +   P +++           +Y PIF ++QF  Y GWLKVAE +INP+G DD+DF+   LI+RN Q+  + VD++
Sbjct:    1 MTVTYTARVANARFCGFSKLLLAWRGSIYKVLYKEVLAFFILYTAISITYRFFLLDEQKRYFEKLSIYCNHYASLIPMSFVLGFYVTLIVNRWWSQYTSIPLPDSIMCVLSGGLQGGDERGRLLRRTLMRYASLASLLILRSVSTAVFKRFPTMDHVVEAGFMTREERKKFESLHSPYNKYWIPCVWFTNLAAVARSEGRIKDDNTYKLLLEELNKFRGKCSLLFHYDMISVPLVYTQVVTLAVYSFFLVCLIGRQFLD-------PSQAYPGHDLD----------LYVPIFTLLQFFFYAGWLKVAEQLINPFGEDDDDFETNWLIDRNFQVSMMAVDEM 325
[Close]
BLAST of Bestrophin homolog vs. Ensembl Cavefish
Match: best4 (bestrophin 4 [Source:ZFIN;Acc:ZDB-GENE-070912-6])

HSP 1 Score: 192.2 bits (487), Expect = 9.693e-57
Identity = 113/339 (33.33%), Postives = 195/339 (57.52%), Query Frame = 1 
Query:   79 HGRKNDYFKLLLRWDGSIYKILYXXXXXXXXXXXXXXXXNKNLLSEINQKYFSKFCEYCLYLSETIPIAFVLTFFVPLVVSRRFEQFKMIPWIDKMAIYLSAFLQGRTDDIVIKRRTVIRYMILSMTLCFRSISMPVMDAFESDEQLINAGLATQEEIVKIDSIPFSYNRYFVPLIWAGDIIHRADKHGLISGERCLALLLNEVMSFHEELQSILFYDWISIPLVYTQ-VSTICTYAYFICTVFGGQILGVKMFINFKNSTKPANNVTINYDEITEYLMYFPIFFVIQFVIYMGWLKVAESMINPYGYDDEDFQMVSLIERNLQIGFVIVDKIN-NFPP 1089
            + R   + KLL RW GSIYK+LY EF +F  +Y + +++ + +L++  Q+ F +   +C   ++ IP++FVL F+V     R + Q+   P  D + + +S  + G  +   + RRT++RY  LS  L  RSIS  V   F + + +++A   T+EE+  +D +   +N+Y++PL W  ++  +A + G +  +  L LL++E+ ++  +   +  YDWISIPLVYTQ V T+  Y++F   + G Q +            + A+ + ++ D      +Y P+F +++F  Y GWLKV E +INP+G DD+DF+   LI+RN+Q+  + VD ++ N PP
Sbjct:   11 NARFAGFTKLLFRWKGSIYKLLYKEFLLFCFLYSLFSLIYRCVLTDGQQELFERAARHCNKFAKLIPMSFVL-FYVTQAFQRWWGQYTSFPLPDNLMMVVSGNVHGSDERGRLLRRTLMRYANLSSVLILRSISTRVHKRFPTLQHIVDA-FMTEEEMRTLDHLYSDFNKYWMPLTWFANLASKAREEGRVKDDIALRLLMDELNNYRGKCSMLFHYDWISIPLVYTQQVVTLAVYSFFAFCLIGRQFV----------KPERADELKVHVD------LYVPVFTLLEFFFYAGWLKVGELIINPFGEDDDDFETNQLIDRNIQVSMLAVDDMHQNLPP 331
[Close]
BLAST of Bestrophin homolog vs. Ensembl Cavefish
Match: best1 (bestrophin-2 [Source:NCBI gene;Acc:103045999])

HSP 1 Score: 194.126 bits (492), Expect = 1.130e-54
Identity = 118/341 (34.60%), Postives = 188/341 (55.13%), Query Frame = 1 
Query:   82 GRKNDYFKLLLRWDGSIYKILYXXXXXXXXXXXXXXXXNKNLLSEINQKYFSKFCEYCLYLSETIPIAFVLTFFVPLVVSRRFEQFKMIPWIDKMAIYLSAFLQGRTDDIVIKRRTVIRYMILSMTLCFRSISMPVMDAFESDEQLINAGLATQEEIVKIDSIPFSYNRYFVPLIWAGDIIHRADKHGLISGERCLALLLNEVMSFHEELQSILFYDWISIPLVYTQVSTICTYAYFICTVFGGQILGVKMFINFKNSTKPANNVTINYDEITEYLMYFPIFFVIQFVIYMGWLKVAESMINPYGYDDEDFQMVSLIERNLQIGFVIVDKINNFPPKVTED 1104
             R   +  LLLRW GSIYK+LY E  IF  +Y  I+V+ + LL    ++ F K   YC   ++ IP++FVL F+V LVVSR + QF+ +PW D++A  + A+++G  +   + RR+++RY  LS  L +RSIS  V   F + E L+ AGL T EE  ++D +P  +N+++VP +W  ++  RA   G I+ +  L+ +LN                          V T+  Y++F+  + G Q L         + T+  +   +++        Y P+F ++QF  Y+GWLKVAE +INP+G DD+DF+   L++RNLQ+  + VD++ +  P V  D
Sbjct:   12 ARLGTFSHLLLRWKGSIYKLLYRELLIFTVLYCTISVLYRFLLDNEQRRLFEKLAIYCDQYAQLIPVSFVLGFYVTLVVSRWWGQFESVPWPDRLAALVGAYVRGADEGARLIRRSLVRYANLSGVLIYRSISTAVYKRFPTIEHLVQAGLMTVEERRQLDDLPSPHNKFWVPCMWFVNLALRARTEGRINNDVALSAILN--------------------------VVTVAVYSFFLACLIGRQFL---------DPTQGYSGHDLDF--------YLPVFTLLQFFFYVGWLKVAEQLINPFGEDDDDFETNWLVDRNLQVSLLSVDEMYDLVPLVERD 309
[Close]
BLAST of Bestrophin homolog vs. Ensembl Cavefish
Match: BEST3 (bestrophin 3 [Source:HGNC Symbol;Acc:HGNC:17105])

HSP 1 Score: 124.79 bits (312), Expect = 5.725e-31
Identity = 66/193 (34.20%), Postives = 105/193 (54.40%), Query Frame = 1 
Query:  529 GLATQEEIVKIDSIPFSYNRYFVPLIWAGDIIHRADKHGLISGERCLALLLNEVMSFHEELQSILFYDWISIPLVYTQVSTICTYAYFICTVFGGQILGVKMFINFKNSTKPANNVTINYDEITEYLMYFPIFFVIQFVIYMGWLKVAESMINPYGYDDEDFQMVSLIERNLQIGFVIVDKINNFPPKVTEDV 1107
            G  T EE    +++   + +Y++P +W  ++  +A K G I     L  +L E+  F     ++  YDW+ IPLVYTQV T+  Y +F  ++ G Q L             PA     +     +  +Y P+F ++QF  Y GWLKVAE +INP+G DD+DF+    I+RNLQ+  + VD+++   P++T+DV
Sbjct:   83 GFMTPEEKKIFENLKSPHLKYWIPTVWFTNLASKARKDGRIQDSVDLQTILTEMNRFRTWCSTLFGYDWVGIPLVYTQVVTLAVYTFFSASIIGRQFL------------DPAQGYPGH-----DLDLYVPVFTLLQFFFYSGWLKVAEQLINPFGEDDDDFEANWCIDRNLQVSLMAVDEMHMNIPRMTKDV 258

HSP 2 Score: 53.5286 bits (127), Expect = 2.601e-7
Identity = 39/98 (39.80%), Postives = 58/98 (59.18%), Query Frame = 1 
Query:   16 ISYSSKL*NFNCNMSTSYFGKHGRKNDYFKLLLRWDGSIYKILYXXXXXXXXXXXXXXXXNKNLLSEINQKYFSKFCEYCLYLSETIPIAFVLTFFVP 309
            ++YSSK+ N       ++FG H       +LLLRW GSIYK+LY EF  F  +Y I+++V + +L++  ++ F K   YC   +E IP+ FVL F  P
Sbjct:    3 VTYSSKVAN------ATFFGFH-------RLLLRWRGSIYKLLYREFLFFALLYSILSLVYRWVLTDPQRRLFEKLSIYCDRYAEQIPVTFVLGFMTP 87
[Close]
BLAST of Bestrophin homolog vs. Ensembl Sea Lamprey
Match: best1 (bestrophin 1 [Source:ZFIN;Acc:ZDB-GENE-110411-214])

HSP 1 Score: 228.024 bits (580), Expect = 5.522e-71
Identity = 134/379 (35.36%), Postives = 213/379 (56.20%), Query Frame = 1 
Query:   55 MSTSYFGK--HGRKNDYFKLLLRWDGSIYKILYXXXXXXXXXXXXXXXXNKNLLSEINQKYFSKFCEYCLYLSETIPIAFVLTFFVPLVVSRRFEQFKMIPWIDKMAIYLSAFLQGRTDDIVIKRRTVIRYMILSMTLCFRSISMPVMDAFESDEQLINAGLATQEEIVKIDSIPFSYNRYFVPLIWAGDIIHRADKHGLISGERCLALLLNEVMSFHEELQSILFYDWISIPLVYTQVSTICTYAYFICTVFGGQILGVKMFINFKNSTKPANNVTINYDEITEYLMYFPIFFVIQFVIYMGWLKVAESMINPYGYDDEDFQMVSLIERNLQIGFVIVDKINNFPPKVTEDVVPIYIKP----NFNTLQMDKELFQNS 1173
            M+ +Y  K  + R   + +LLLRW GSIYK+LY EF IF+ +++ ++ V + +L E  ++YF K   YC   +E IP++FVL F+V LVVSR + Q++ +PW D++   ++  + G  +   + RRT++RY  LS  L  RS+S  V   F + + ++ AG  T  E  K D +   +N+++VP +W  ++  +A   G I     L L+LN++ +F      +  YDW+SIPLVYTQV T+  Y++F+  + G Q LG + +        P +++           +Y P+F ++QF  Y GWLKVAE +INP+G DD+DF+    ++RNLQ+  + VD++    P +  DV    I P       +L   K  FQ S
Sbjct:    1 MTVTYSNKVANARLGGFSQLLLRWKGSIYKLLYKEFCIFLVLFFTLSSVYRYMLQENQKRYFEKLAMYCNKYAELIPVSFVLGFYVTLVVSRWWSQYESLPWPDRLMHLVACNVHGADERGRLLRRTLMRYANLSALLILRSVSTAVYKRFPTMDHVVEAGFMTPAERRKFDGLRSPHNKFWVPCVWFANLAAQAKAEGRILDNVSLQLILNDLNNFRSCCSMLYSYDWVSIPLVYTQVVTVAVYSFFLACLIGRQFLGPQGY--------PGHDMD----------LYIPVFTLLQFFFYAGWLKVAEQLINPFGEDDDDFEANWCVDRNLQVSLMGVDEMYRDLPPLEHDVYWDDISPCPPYTGASLVHHKASFQGS 361
[Close]
BLAST of Bestrophin homolog vs. Ensembl Sea Lamprey
Match: best2 (bestrophin 2 [Source:ZFIN;Acc:ZDB-GENE-090312-127])

HSP 1 Score: 212.616 bits (540), Expect = 1.331e-63
Identity = 131/393 (33.33%), Postives = 208/393 (52.93%), Query Frame = 1 
Query:   55 MSTSYFGK--HGRKNDYFKLLLRWDGSIYKILYXXXXXXXXXXXXXXXXNKNLLSEINQKYFSKFCEYCLYLSETIPIAFVLTFFVPLVVSRRFEQFKMIPWIDKMAIYLSAFLQGRTDDIVIKRRTVIRYMILSMTLCFRSISMPVMDAFESDEQLINAGLATQEEIVKIDSIPFSYNRYFVPLIWAGDIIHRADKHGLISGERCLALLLNEVMSFHEELQSILFYDWISIPLVYTQVSTICTYAYFICTVFGGQILGVKMFINFKNSTKPANNVTINYDEITEYLMYFPIFFVIQFVIYMGWLKVAESMINPYGYDDEDFQMVSLIERNLQIGFVIVDKINNFPPKVTEDVV-------PIYIKPNFNTLQMDKELFQNSQGMVDDDNAEF 1206
            M+ +Y  +  + R   + KLLL+W GSIYK+LY EF+I+  +Y  +++ ++  LSE  ++ F K   YC   +  IP+     F+V LVVSR + Q+  IP  D++   ++  + G  +   + RRT++RY  LS  L  RS+S  V   F + + ++ AG  T++E  + D +  SYN+Y+VP +W   +  +A   G +  +  L LLL+E+  +      +  YDWIS+PLVYTQV T+  Y++F+  + G Q L             PA     +     +  +Y P+F ++QF  Y GWLKVAE +INP+G DD+DF+   LI+RNLQ+  + VD++    P +  D+        P Y     +TL     L       +  D+ EF
Sbjct:    1 MTVTYTNRVANARLCGFSKLLLQWRGSIYKLLYREFSIYFMMYAALSLTSRFALSEDQKRLFEKLSLYCNNYANLIPVRSCSGFYVALVVSRWWSQYTSIPTPDRLMCAVAGTVHGVDERGRLLRRTLMRYANLSALLILRSVSTAVYKRFPTMDHVVEAGFMTRDERKRFDGLRCSYNKYWVPCVWLSSLAAQARAEGRVRDDVALKLLLDEMNVYRGNCGMLFHYDWISVPLVYTQVVTVAVYSFFLACLIGRQFL------------DPAQGYPGH-----DMDLYIPVFTLLQFFFYAGWLKVAEQLINPFGEDDDDFETNFLIDRNLQVSMLAVDEMYQNLPLLQRDMYWNASDPRPPYTAATMSTLHKPSFLGSAFDMSMHKDDMEF 376
[Close]
BLAST of Bestrophin homolog vs. Ensembl Medaka
Match: BEST3 (bestrophin 3 [Source:NCBI gene;Acc:101172121])

HSP 1 Score: 223.787 bits (569), Expect = 6.316e-66
Identity = 124/337 (36.80%), Postives = 201/337 (59.64%), Query Frame = 1 
Query:   97 YFKLLLRWDGSIYKILYXXXXXXXXXXXXXXXXNKNLLSEINQKYFSKFCEYCLYLSETIPIAFVLTFFVPLVVSRRFEQFKMIPWIDKMAIYLSAFLQGRTDDIVIKRRTVIRYMILSMTLCFRSISMPVMDAFESDEQLINAGLATQEEIVKIDSIPFSYNRYFVPLIWAGDIIHRADKHGLISGERCLALLLNEVMSFHEELQSILFYDWISIPLVYTQVSTICTYAYFICTVFGGQILGVKMFINFKNSTKPANNVTINYDEITEYLMYFPIFFVIQFVIYMGWLKVAESMINPYGYDDEDFQMVSLIERNLQIGFVIVDKINNFPPKVTEDV 1107
            + +LLLRW GSIYK+LY EF +F  +Y I++++ +  LSE  ++ F K   YC   +E IP+ FVL F+V LVV+R + QF  +PW D++  ++S+ +QG+ +   + RRT++RY+ L+  L FRS+S  V   F + + ++ AG  T EE    ++I   + +Y++P++W  ++  RA + G I     L  +LNE+ +F     ++  YDW+ IPLVYTQV T+  Y +F   + G Q L             P +++           +Y P+F ++QF  Y GWLKVAE +INP+G DD+DF+   +I+RNLQ+  + VD+++   P +T+D+
Sbjct:   17 FHRLLLRWRGSIYKLLYREFLLFALLYTILSLIYRLALSEQQKRLFEKLSIYCDRYAEQIPVTFVLGFYVTLVVNRWWNQFLNLPWPDRLMFHISSCVQGKDEYGRLLRRTLVRYINLTSLLIFRSVSTAVCKRFPTIDHVVEAGFMTPEERKVFENIRSPHLKYWIPVVWFSNLASRARQEGRIQDAIDLQNILNEMNTFRTWCATLFGYDWVGIPLVYTQVVTLAVYTFFFACIIGRQFLDPAQ-------GHPGHDLD----------LYVPVFTLLQFFFYSGWLKVAEQLINPFGEDDDDFEANWIIDRNLQVSLLAVDEMHMNLPHMTKDI 336
[Close]
BLAST of Bestrophin homolog vs. Ensembl Medaka
Match: best1 (bestrophin-2 [Source:NCBI gene;Acc:101167866])

HSP 1 Score: 215.312 bits (547), Expect = 2.630e-62
Identity = 127/337 (37.69%), Postives = 199/337 (59.05%), Query Frame = 1 
Query:   97 YFKLLLRWDGSIYKILYXXXXXXXXXXXXXXXXNKNLLSEINQKYFSKFCEYCLYLSETIPIAFVLTFFVPLVVSRRFEQFKMIPWIDKMAIYLSAFLQGRTDDIVIKRRTVIRYMILSMTLCFRSISMPVMDAFESDEQLINAGLATQEEIVKIDSIPFSYNRYFVPLIWAGDIIHRADKHGLISGERCLALLLNEVMSFHEELQSILFYDWISIPLVYTQVSTICTYAYFICTVFGGQILGVKMFINFKNSTKPANNVTINYDEITEYLMYFPIFFVIQFVIYMGWLKVAESMINPYGYDDEDFQMVSLIERNLQIGFVIVDKINNFPPKVTEDV 1107
            +F LLLRW GSIYK+LY E  IF  +YY +++V   +L    ++ F +   YC   +E IP++FVL F+V LVVSR + QF+ IPW D++A  +   ++G  +   + RR ++RY+ LS  L +RS+S  V   F + E L+ A L T EE+   + +P  +N+++VP +W  ++  RA   G I+ +  L  +L E+ S   +   +  YDWIS+PLVYTQV+T+  Y++F+  + G Q L             P ++V            Y P+F ++QF  Y+GWLKVAE +INP+G DD+DF+   +++RNLQ+  + VD++ +  P V +DV
Sbjct:   17 FFHLLLRWKGSIYKLLYRELIIFTLLYYFLSLVYY-MLDNDQRRLFERLSIYCDRYAELIPVSFVL-FYVTLVVSRWWGQFENIPWPDRLAALVGGHVRGTDEASRLTRRALMRYVNLSGVLIYRSVSTAVYKRFPTTEHLVQA-LMTSEELRHFEELPSPHNKFWVPCMWFVNLALRARTEGRINNDVALTAILTELNSLRAKCMKLYGYDWISLPLVYTQVATVAVYSFFLACLIGRQFLDPAQGY-------PGHDVDF----------YLPVFTLLQFFFYVGWLKVAEQLINPFGEDDDDFETNWVVDRNLQVSLLSVDEMYDSLPLVEKDV 333
[Close]
BLAST of Bestrophin homolog vs. Ensembl Medaka
Match: best2 (bestrophin 2 [Source:NCBI gene;Acc:110015962])

HSP 1 Score: 211.46 bits (537), Expect = 1.335e-61
Identity = 126/352 (35.80%), Postives = 196/352 (55.68%), Query Frame = 1 
Query:   55 MSTSYFGK--HGRKNDYFKLLLRWDGSIYKILYXXXXXXXXXXXXXXXXNKNLLSEINQKYFSKFCEYCLYLSETIPIAFVLTFFVPLVVSRRFEQFKMIPWIDKMAIYLSAFLQGRTDDIVIKRRTVIRYMILSMTLCFRSISMPVMDAFESDEQLINAGLATQEEIVKIDSIPFSYNRYFVPLIWAGDIIHRADKHGLISGERCLALLLNEVMSFHEELQSILFYDWISIPLVYTQVSTICTYAYFICTVFGGQILGVKMFINFKNSTKPANNVTINYDEITEYLMYFPIFFVIQFVIYMGWLKVAESMINPYGYDDEDFQMVSLIERNLQIGFVIVDKINNFPPKVTED 1104
            M+ +Y  +  + R   + KLLL W GSIYK+LY EF  F  +Y  I++  +  L E  ++YF K   YC + +  IP++FVL F+V L+V+R + Q+  IP  D++   LS  LQG  +   + RR+++RY  LS  L  RS+S  V   F + + ++ AG  T+EE  K + +   YN+Y++P +W  ++   A   G I  +  L LLL E+ +F  +   +  YD +S+PLVYTQV T+  Y++F+  + G Q L             P+        +  +  +Y PIF ++QF  Y GWLKVAE +INP+G DD+DF+   LI+RN Q+  + VD++    P +  D
Sbjct:    1 MTVTYTARVANARFCGFSKLLLAWKGSIYKVLYKEFLAFFVLYAAISITYRFFLYEDQKRYFEKLAIYCNHYASLIPMSFVLGFYVTLIVNRWWNQYTSIPLPDRIMCVLSGGLQGNDERGRLLRRSMMRYASLSALLILRSVSTAVFKRFPTMDHVVEAGFMTREERKKFEGLHSPYNKYWIPCVWFTNLAAVARCEGRIRDDHALKLLLEELNAFRGKCSLLFHYDMVSVPLVYTQVVTLAVYSFFLVCLIGRQFL------------DPSQGY-----QGHDLDLYVPIFTLLQFFFYAGWLKVAEQLINPFGEDDDDFETNWLIDRNFQVSMMAVDEMYGDLPVMERD 335
[Close]
BLAST of Bestrophin homolog vs. Planmine SMEST
Match: SMESG000003961.1 (SMESG000003961.1)

HSP 1 Score: 806.209 bits (2081), Expect = 0.000e+0
Identity = 410/412 (99.51%), Postives = 410/412 (99.51%), Query Frame = 1 
Query:   55 MSTSYFGKHGRKNDYFKLLLRWDGSIYKILYXXXXXXXXXXXXXXXXNKNLLSEINQKYFSKFCEYCLYLSETIPIAFVLTFFVPLVVSRRFEQFKMIPWIDKMAIYLSAFLQGRTDDIVIKRRTVIRYMILSMTLCFRSISMPVMDAFESDEQLINAGLATQEEIVKIDSIPFSYNRYFVPLIWAGDIIHRADKHGLISGERCLALLLNEVMSFHEELQSILFYDWISIPLVYTQVSTICTYAYFICTVFGGQILGVKMFINFKNSTKPANNVTINYDEITEYLMYFPIFFVIQFVIYMGWLKVAESMINPYGYDDEDFQMVSLIERNLQIGFVIVDKINNFPPKVTEDVVPIYIKPNFNTLQMDKELFQNSQGMVDDDNAEFLEKSTVMYRKNLLFGSNIMDDINIIGTE 1290
            MSTSYFGKHGRKNDYFKLLLRWDGSIYKILYTEFTIFIAIYYIIAVVNKNLLSEINQKYFSKFCEYCLYLSETIPIAFVLTFFVPLVVSRRFEQFKMIPWIDKMAIYLSAFLQGRTDDIVIKRRTVIRYMILSMTLCFRSISMPVMDAFESDEQLINAGLATQEEIVKIDSIPFSYNRYFVPLIWAGDIIHRADKHGLISGERCLALLLNEVMSFHEELQSILFYDWISIPLVYTQVSTICTYAYFICTVFGGQILGVKMFINFKNSTKPANNVTINYDEITEYLMYFPIFFVIQFVIYMGWLKVAESMINPYGYDDEDFQMVSLIERNLQIGFVIVDKINNFPPKVTEDVVPIYIKPNFNTLQMDKELFQNSQGMVDDDNAEFLEKSTVMYRKNLLFGSNIMDDINIIG  
Sbjct:    1 MSTSYFGKHGRKNDYFKLLLRWDGSIYKILYTEFTIFIAIYYIIAVVNKNLLSEINQKYFSKFCEYCLYLSETIPIAFVLTFFVPLVVSRRFEQFKMIPWIDKMAIYLSAFLQGRTDDIVIKRRTVIRYMILSMTLCFRSISMPVMDAFESDEQLINAGLATQEEIVKIDSIPFSYNRYFVPLIWAGDIIHRADKHGLISGERCLALLLNEVMSFHEELQSILFYDWISIPLVYTQVSTICTYAYFICTVFGGQILGVKMFINFKNSTKPANNVTINYDEITEYLMYFPIFFVIQFVIYMGWLKVAESMINPYGYDDEDFQMVSLIERNLQIGFVIVDKINNFPPKVTEDVVPIYIKPNFNTLQMDKELFQNSQGMVDDDNAEFLEKSTVMYRKNLLFGSNIMDDINIIGVS 412
[Close]
BLAST of Bestrophin homolog vs. Planmine SMEST
Match: SMESG000003961.1 (SMESG000003961.1)

HSP 1 Score: 721.85 bits (1862), Expect = 0.000e+0
Identity = 377/410 (91.95%), Postives = 377/410 (91.95%), Query Frame = 1 
Query:   55 MSTSYFGKHGRKNDYFKLLLRWDGSIYKILYXXXXXXXXXXXXXXXXNKNLLSEINQKYFSKFCEYCLYLSETIPIAFVLTFFVPLVVSRRFEQFKMIPWIDKMAIYLSAFLQGRTDDIVIKRRTVIRYMILSMTLCFRSISMPVMDAFESDEQLINAGLATQEEIVKIDSIPFSYNRYFVPLIWAGDIIHRADKHGLISGERCLALLLNEVMSFHEELQSILFYDWISIPLVYTQVSTICTYAYFICTVFGGQILGVKMFINFKNSTKPANNVTINYDEITEYLMYFPIFFVIQFVIYMGWLKVAESMINPYGYDDEDFQMVSLIERNLQIGFVIVDKINNFPPKVTEDVVPIYIKPNFNTLQMDKELFQNSQGMVDDDNAEFLEKSTVMYRKNLLFGSNIMDDINIIG 1284
            MSTSYFGKHGRKNDYFKLLLRWDGSIYKILYTEFTIFIAIYYIIAVVNKNLLSEINQK                                 FEQFKMIPWIDKMAIYLSAFLQGRTDDIVIKRRTVIRYMILSMTLCFRSISMPVMDAFESDEQLINAGLATQEEIVKIDSIPFSYNRYFVPLIWAGDIIHRADKHGLISGERCLALLLNEVMSFHEELQSILFYDWISIPLVYTQVSTICTYAYFICTVFGGQILGVKMFINFKNSTKPANNVTINYDEITEYLMYFPIFFVIQFVIYMGWLKVAESMINPYGYDDEDFQMVSLIERNLQIGFVIVDKINNFPPKVTEDVVPIYIKPNFNTLQMDKELFQNSQGMVDDDNAEFLEKSTVMYRKNLLFGSNIMDDINIIG
Sbjct:    1 MSTSYFGKHGRKNDYFKLLLRWDGSIYKILYTEFTIFIAIYYIIAVVNKNLLSEINQK---------------------------------FEQFKMIPWIDKMAIYLSAFLQGRTDDIVIKRRTVIRYMILSMTLCFRSISMPVMDAFESDEQLINAGLATQEEIVKIDSIPFSYNRYFVPLIWAGDIIHRADKHGLISGERCLALLLNEVMSFHEELQSILFYDWISIPLVYTQVSTICTYAYFICTVFGGQILGVKMFINFKNSTKPANNVTINYDEITEYLMYFPIFFVIQFVIYMGWLKVAESMINPYGYDDEDFQMVSLIERNLQIGFVIVDKINNFPPKVTEDVVPIYIKPNFNTLQMDKELFQNSQGMVDDDNAEFLEKSTVMYRKNLLFGSNIMDDINIIG 377
[Close]
BLAST of Bestrophin homolog vs. Planmine SMEST
Match: SMESG000057100.1 (SMESG000057100.1)

HSP 1 Score: 244.973 bits (624), Expect = 2.003e-77
Identity = 140/356 (39.33%), Postives = 218/356 (61.24%), Query Frame = 1 
Query:   55 MSTSYFGKHGRKNDY--FKLLLRWDGSIYKILYXXXXXXXXXXXXXXXXNKNLLSEINQK---YFSKFCEYCLYLSETIPIAFVLTFFVPLVVSRRFEQFKMIPWIDKMAIYLSAFLQGRTDDIVIKRRTVIRYMILSMTLCFRSISMPVMDAFESDEQLINAGLATQEEIVKIDSIPFSYNRYFVPLIWAGDIIHRADKHGLISGERCLALLLNEVMSFHEELQSILFYDWISIPLVYTQVSTICTYAYFICTVFGGQILGVKMFINFKNSTKPANNVTINYDEITEYLMYFPIFFVIQFVIYMGWLKVAESMINPYGYDDEDFQMVSLIERNLQIGFVIVDKINNFPPKVTEDV 1107
            M+  Y G  G+ + +  F +LLRW GS++K++  E  IF +IY  ++++ + +L   + K    FS  C+YC+ +   IP+AFVL F+V +V++   EQFK +PW D +A+ LSAFLQG TD+IV+ RRT++RY+ + M + FR IS   +  F + E +  AGL    E+  + SI  SYN+Y+VPL+WA ++I  A +  LI  +R L +L+  + SF   L  +  + WIS PLVYTQV+TI  Y YF+  +   Q      FI+ K+                +Y+  FP F ++QF+ Y+GWLKVAE++++P+G  D+DF M  LIERN+Q+ ++IVD ++   P++ +DV
Sbjct:    1 MTVIYSGSLGKVHFWTVFAILLRWKGSVFKLVRFEALIFFSIYGSLSLIYRFVLVPYHTKSEFVFSFMCQYCIEIMNRIPVAFVLGFYVSIVINWWSEQFKSLPWPDDIALQLSAFLQGETDEIVLLRRTIVRYVNMGMIIAFRGISKSTLKLFSTLESMKKAGLMNMSELKALQSIDRSYNKYYVPLVWAANLIRDARRKNLIKDDRQLDVLVETLTSFRGILCDLFVHQWISPPLVYTQVATITVYCYFLAALMAWQ------FISGKD----------------DYI--FPFFGMLQFLFYVGWLKVAENLLDPFGEKDDDFDMTFLIERNVQMAYLIVDDMHRDIPEIKKDV 332
[Close]
BLAST of Bestrophin homolog vs. Planmine SMEST
Match: SMESG000069980.1 (SMESG000069980.1)

HSP 1 Score: 228.794 bits (582), Expect = 7.455e-71
Identity = 128/383 (33.42%), Postives = 217/383 (56.66%), Query Frame = 1 
Query:   55 MSTSYFGKHGRKNDY--FKLLLRWDGSIYKILYXXXXXXXXXXXXXXXXNKNLLSEINQKYFSKFCEYCLYLSETIPIAFVLTFFVPLVVSRRFEQFKMIPWIDKMAIYLSAFLQGRTDDIVIKRRTVIRYMILSMTLCFRSISMPVMDAFESDEQLINAGLATQEEIVKIDSIPFSYNRYFVPLIWAGDIIHRADKHGLISGERCLALLLNEVMSFHEELQSILFYDWISIPLVYTQVSTICTYAYFICTVFGGQILGVKMFINFKNSTKPANNVTINYDEITEYLMYFPIFFVIQFVIYMGWLKVAESMINPYGYDDEDFQMVSLIERNLQIGFVIVDKINNFPPKVTEDVVPIYIKPNFNTLQMDKELFQNSQGMVDDDN 1197
            M+ SY  K    N +  FKLLL W GSIYK +  E  I+I +  +I++++   L+   +  F  FC +C   +  IP+  VL F+V LVV R  +QF  +PW D +A+Y++ F+ G  D   + RR+++RY+I+S  LC+ SIS      F +++ L+  GL T EE+ +++    + N++FVP+ WA +++ +A K   +   + + LL NE+  F + L+ +  YDWI+ PL+YTQ++ I  Y+YFI ++FG Q +          +++ A+ +           +Y P+F  ++F+ YMGWLKVA+ +INP+G D++DF+M  +I RN +  F+ VD+ +   P + +D+   Y++ N   +         S G  +  N
Sbjct:    1 MTVSYVSKIATSNSFRVFKLLLTWKGSIYKTIRIELFIYIVLNALISLLHY-FLTGYYRLIFESFCSFCAKGTGFIPVGLVLGFYVTLVVQRWTDQFVTLPWPDSLAVYVNTFILGAGDTPRLIRRSIMRYVIVSQILCYSSISSKAKRVFSTNQTLVEQGLLTTEELSRLEKFETTSNKHFVPIAWAQELVVKAQKEKYLMDNKRVWLLANELNEFRDRLRILFAYDWINPPLIYTQIAIITMYSYFIFSIFGKQFI-------IHGTSQSAHGMN----------LYVPVFGALEFINYMGWLKVAQCLINPFGDDEDDFEMDQIILRNFEYSFITVDQWHQQCPPLQQDMY--YLQKNARLIDSCNRFIGGSIGKANKIN 363
[Close]
BLAST of Bestrophin homolog vs. Planmine SMEST
Match: SMESG000054993.1 (SMESG000054993.1)

HSP 1 Score: 227.639 bits (579), Expect = 7.252e-70
Identity = 131/337 (38.87%), Postives = 205/337 (60.83%), Query Frame = 1 
Query:   97 YFKLLLRWDGSIYKILYXXXXXXXXXXXXXXXXNKNLLSEINQKYFSKFCEYCLYLSETIPIAFVLTFFVPLVVSRRFEQFKMIPWIDKMAIYLSAFLQGRTDDIVIKRRTVIRYMILSMTLCFRSISMPVMDAFESDEQLINAGLATQEEIVKIDSIPFSYNRYFVPLIWAGDIIHRADKHGLISGERCLALLLNEVMSFHEELQSILFYDWISIPLVYTQVSTICTYAYFICTVFGGQILGVKMFINFKNSTKPANNVTINYDEITEYLMYFPIFFVIQFVIYMGWLKVAESMINPYGYDDEDFQMVSLIERNLQIGFVIVDKINNFPPKVTEDV 1107
            + +LLLRW GSIYKI++ E  +F  +Y  ++ + +  L  I +K F +FC +    ++ IP+ FVL F+V LVVSR + QF  IPW D MAIY+S F+ G  D  V+ RRT++RY+ LS  + F SIS      F   + LI  GL T++E   ++    +  +YFVP +WA +++++A+   +  GER +  L+ E+  F   L  I  +DWI+ PLVYTQ++TI  +AYF+  VF  Q                     I+ D++    +Y P+F  +QFV YMGWLKVAES+INP+G DD+DF++  +I RN+++ ++I+D++++  P++ +DV
Sbjct:   17 FLRLLLRWKGSIYKIIWFEMIVFATLYTGLSCLYRFGLYGIYKKRFEEFCAFSKKNADMIPVPFVLGFYVTLVVSRWWNQFMEIPWPDSMAIYVSTFILGNDDKSVMYRRTIMRYLNLSFCMTFASISSKAKRMFPDLKTLIENGLLTKDEEKILNEYETNNAKYFVPALWASNLVYQAESEKMTIGERGVETLIEEIGKFRGSLGMIYCFDWINPPLVYTQIATISVHAYFMIFVFAEQF--------------------ISKDKVD---VYVPMFGFLQFVFYMGWLKVAESLINPFGDDDDDFEIDEMIHRNIKMSYLIIDEMHDSYPELDKDV 330
The following BLAST results are available for this feature:
BLAST of Bestrophin homolog vs. Ensembl Human
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Human e!99)
Total hits: 5
Match NameE-valueIdentityDescription
BEST39.730e-6934.64bestrophin 3 [Source:HGNC Symbol;Acc:HGNC:17105][more]
BEST42.336e-6737.68bestrophin 4 [Source:HGNC Symbol;Acc:HGNC:17106][more]
BEST26.836e-6536.55bestrophin 2 [Source:HGNC Symbol;Acc:HGNC:17107][more]
BEST26.836e-6536.55bestrophin 2 [Source:HGNC Symbol;Acc:HGNC:17107][more]
BEST26.836e-6536.55bestrophin 2 [Source:HGNC Symbol;Acc:HGNC:17107][more]
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BLAST of Bestrophin homolog vs. Ensembl Celegans
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99)
Total hits: 5
Match NameE-valueIdentityDescription
best-231.648e-5934.62Bestrophin homolog [Source:UniProtKB/TrEMBL;Acc:A... [more]
best-241.489e-5732.51Bestrophin homolog 24 [Source:UniProtKB/Swiss-Pro... [more]
best-44.137e-5730.92Bestrophin homolog [Source:UniProtKB/TrEMBL;Acc:O... [more]
best-31.227e-5632.24Bestrophin homolog [Source:UniProtKB/TrEMBL;Acc:O... [more]
best-142.353e-5531.96Bestrophin homolog 14 [Source:UniProtKB/Swiss-Pro... [more]
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BLAST of Bestrophin homolog vs. Ensembl Fly
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99)
Total hits: 5
Match NameE-valueIdentityDescription
Best34.015e-6734.43gene:FBgn0036492 transcript:FBtr0075618[more]
Best43.385e-6534.90gene:FBgn0036491 transcript:FBtr0113172[more]
Best13.741e-6334.88gene:FBgn0040238 transcript:FBtr0082183[more]
Best15.520e-6334.88gene:FBgn0040238 transcript:FBtr0337020[more]
Best18.347e-6334.88gene:FBgn0040238 transcript:FBtr0114590[more]
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BLAST of Bestrophin homolog vs. Ensembl Zebrafish
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99)
Total hits: 5
Match NameE-valueIdentityDescription
best11.024e-6936.95bestrophin 1 [Source:ZFIN;Acc:ZDB-GENE-110411-214][more]
best43.404e-6433.78bestrophin 4 [Source:ZFIN;Acc:ZDB-GENE-070912-6][more]
best25.091e-6233.73bestrophin 2 [Source:ZFIN;Acc:ZDB-GENE-090312-127][more]
best45.263e-6135.22bestrophin 4 [Source:ZFIN;Acc:ZDB-GENE-070912-6][more]
best11.829e-3535.08bestrophin 1 [Source:ZFIN;Acc:ZDB-GENE-110411-214][more]
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BLAST of Bestrophin homolog vs. Ensembl Xenopus
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99)
Total hits: 5
Match NameE-valueIdentityDescription
best14.151e-7035.97bestrophin 1 [Source:NCBI gene;Acc:100302038][more]
best13.056e-6937.68bestrophin 1 [Source:NCBI gene;Acc:100302038][more]
best18.274e-6937.68bestrophin 1 [Source:NCBI gene;Acc:100302038][more]
best11.133e-6838.30bestrophin 1 [Source:NCBI gene;Acc:100302038][more]
ifitm31.021e-6736.26interferon induced transmembrane protein 3 [Source... [more]
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BLAST of Bestrophin homolog vs. Ensembl Mouse
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99)
Total hits: 5
Match NameE-valueIdentityDescription
Best14.828e-6934.27bestrophin 1 [Source:MGI Symbol;Acc:MGI:1346332][more]
Best14.538e-6734.27bestrophin 1 [Source:MGI Symbol;Acc:MGI:1346332][more]
Best23.827e-6638.01bestrophin 2 [Source:MGI Symbol;Acc:MGI:2387588][more]
Best23.827e-6638.01bestrophin 2 [Source:MGI Symbol;Acc:MGI:2387588][more]
Best23.827e-6638.01bestrophin 2 [Source:MGI Symbol;Acc:MGI:2387588][more]
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BLAST of Bestrophin homolog vs. UniProt/SwissProt
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt)
Total hits: 5
Match NameE-valueIdentityDescription
sp|Q8NFU0|BEST4_HUMAN1.122e-6637.68Bestrophin-4 OS=Homo sapiens OX=9606 GN=BEST4 PE=2... [more]
sp|O88870|BEST1_MOUSE3.174e-6634.27Bestrophin-1 OS=Mus musculus OX=10090 GN=Best1 PE=... [more]
sp|Q8BGM5|BEST2_MOUSE2.594e-6538.01Bestrophin-2 OS=Mus musculus OX=10090 GN=Best2 PE=... [more]
sp|Q8NFU1|BEST2_HUMAN3.283e-6436.55Bestrophin-2 OS=Homo sapiens OX=9606 GN=BEST2 PE=1... [more]
sp|Q6H1V1|BEST3_MOUSE3.439e-6336.81Bestrophin-3 OS=Mus musculus OX=10090 GN=Best3 PE=... [more]
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BLAST of Bestrophin homolog vs. TrEMBL
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL)
Total hits: 5
Match NameE-valueIdentityDescription
A0A2R2ML911.139e-7638.87Bestrophin homolog OS=Lingula unguis OX=7574 GN=LO... [more]
A0A1S3K2B31.425e-7638.87Bestrophin homolog OS=Lingula unguis OX=7574 GN=LO... [more]
C1L4411.856e-7239.05Bestrophin homolog OS=Schistosoma japonicum OX=618... [more]
A0A3Q0KLS64.318e-7238.76Bestrophin homolog OS=Schistosoma mansoni OX=6183 ... [more]
A0A504Z0E65.631e-7138.53Bestrophin homolog OS=Fasciola gigantica OX=46835 ... [more]
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BLAST of Bestrophin homolog vs. Ensembl Cavefish
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99)
Total hits: 5
Match NameE-valueIdentityDescription
best11.652e-6938.12bestrophin-2 [Source:NCBI gene;Acc:103045999][more]
best21.116e-6035.96bestrophin 2 [Source:ZFIN;Acc:ZDB-GENE-090312-127][more]
best49.693e-5733.33bestrophin 4 [Source:ZFIN;Acc:ZDB-GENE-070912-6][more]
best11.130e-5434.60bestrophin-2 [Source:NCBI gene;Acc:103045999][more]
BEST35.725e-3134.20bestrophin 3 [Source:HGNC Symbol;Acc:HGNC:17105][more]
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BLAST of Bestrophin homolog vs. Ensembl Sea Lamprey
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99)
Total hits: 2
Match NameE-valueIdentityDescription
best15.522e-7135.36bestrophin 1 [Source:ZFIN;Acc:ZDB-GENE-110411-214][more]
best21.331e-6333.33bestrophin 2 [Source:ZFIN;Acc:ZDB-GENE-090312-127][more]
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BLAST of Bestrophin homolog vs. Ensembl Yeast
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46)
Total hits: 0
Match NameE-valueIdentityDescription
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BLAST of Bestrophin homolog vs. Ensembl Nematostella
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46)
Total hits: 0
Match NameE-valueIdentityDescription
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BLAST of Bestrophin homolog vs. Ensembl Medaka
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99)
Total hits: 3
Match NameE-valueIdentityDescription
BEST36.316e-6636.80bestrophin 3 [Source:NCBI gene;Acc:101172121][more]
best12.630e-6237.69bestrophin-2 [Source:NCBI gene;Acc:101167866][more]
best21.335e-6135.80bestrophin 2 [Source:NCBI gene;Acc:110015962][more]
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BLAST of Bestrophin homolog vs. Planmine SMEST
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST)
Total hits: 5
Match NameE-valueIdentityDescription
SMESG000003961.10.000e+099.51SMESG000003961.1[more]
SMESG000003961.10.000e+091.95SMESG000003961.1[more]
SMESG000057100.12.003e-7739.33SMESG000057100.1[more]
SMESG000069980.17.455e-7133.42SMESG000069980.1[more]
SMESG000054993.17.252e-7038.87SMESG000054993.1[more]
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Sequences
The following sequences are available for this feature:

transcript sequence

>SMED30010746 ID=SMED30010746|Name=Bestrophin homolog|organism=Schmidtea mediterranea sexual|type=transcript|length=1360bp
ATTTAAACTCATTAAATAAGTTATAGCTCAAAGTTATAAAATTTTAATTG
TAATATGAGCACGAGCTATTTCGGTAAACATGGAAGGAAAAATGATTATT
TTAAACTCTTATTGCGATGGGATGGAAGCATATATAAGATTTTATATACT
GAATTTACAATTTTTATAGCGATATATTACATCATAGCTGTAGTAAACAA
AAATCTTTTGTCAGAAATTAATCAAAAATATTTTTCTAAATTTTGTGAAT
ACTGTCTTTATTTATCTGAAACTATACCCATAGCATTTGTTCTAACGTTT
TTTGTACCTTTGGTTGTTTCTCGAAGGTTTGAACAATTTAAAATGATTCC
TTGGATAGATAAAATGGCTATATATTTGTCTGCGTTTCTTCAAGGACGTA
CGGATGATATAGTTATTAAAAGGCGTACAGTTATCAGGTATATGATATTA
TCCATGACTCTTTGTTTTCGTAGTATTTCAATGCCTGTTATGGATGCTTT
TGAATCAGACGAACAGTTGATAAATGCTGGGTTAGCAACGCAAGAAGAAA
TAGTAAAAATTGACTCAATACCATTTTCTTATAATCGCTATTTCGTTCCT
TTGATTTGGGCAGGAGATATAATTCACAGAGCTGATAAACATGGGTTAAT
TAGTGGTGAAAGATGTTTGGCCCTCCTCTTAAATGAAGTCATGTCTTTTC
ATGAGGAACTACAGTCCATTCTATTTTATGACTGGATAAGTATACCACTT
GTCTATACGCAGGTTAGCACAATATGCACATATGCTTATTTTATCTGCAC
TGTTTTTGGGGGTCAAATATTGGGAGTTAAAATGTTCATAAATTTTAAAA
ATTCAACTAAGCCAGCTAATAATGTTACTATTAATTACGATGAAATTACG
GAATATTTGATGTATTTCCCAATATTTTTCGTGATACAATTTGTCATTTA
TATGGGGTGGCTTAAAGTTGCCGAATCAATGATTAATCCGTACGGTTATG
ATGATGAAGATTTTCAGATGGTTTCATTAATCGAAAGAAACTTACAAATT
GGATTCGTAATAGTAGATAAAATTAATAATTTCCCACCGAAGGTGACTGA
AGATGTCGTCCCGATATACATAAAACCAAATTTTAATACATTGCAAATGG
ACAAGGAACTTTTTCAAAATTCACAAGGAATGGTTGACGATGACAATGCT
GAATTTTTGGAAAAGAGTACTGTAATGTATAGGAAAAATTTGCTGTTTGG
AAGCAACATAATGGACGATATAAATATAATAGGCACAGAAGAGCAGAATT
CAGATAAATAATTTTAATTTTGCATCTTTACTAAACTTGTTATGGTTTGT
TGAAATAAAG
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protein sequence of SMED30010746-orf-1

>SMED30010746-orf-1 ID=SMED30010746-orf-1|Name=SMED30010746-orf-1|organism=Schmidtea mediterranea sexual|type=polypeptide|length=419bp
MSTSYFGKHGRKNDYFKLLLRWDGSIYKILYTEFTIFIAIYYIIAVVNKN
LLSEINQKYFSKFCEYCLYLSETIPIAFVLTFFVPLVVSRRFEQFKMIPW
IDKMAIYLSAFLQGRTDDIVIKRRTVIRYMILSMTLCFRSISMPVMDAFE
SDEQLINAGLATQEEIVKIDSIPFSYNRYFVPLIWAGDIIHRADKHGLIS
GERCLALLLNEVMSFHEELQSILFYDWISIPLVYTQVSTICTYAYFICTV
FGGQILGVKMFINFKNSTKPANNVTINYDEITEYLMYFPIFFVIQFVIYM
GWLKVAESMINPYGYDDEDFQMVSLIERNLQIGFVIVDKINNFPPKVTED
VVPIYIKPNFNTLQMDKELFQNSQGMVDDDNAEFLEKSTVMYRKNLLFGS
NIMDDINIIGTEEQNSDK*
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Annotated Terms
The following terms have been associated with this transcript:
Vocabulary: Planarian Anatomy
TermDefinition
PLANA:0000035Category 3 cell
Vocabulary: INTERPRO
TermDefinition
IPR000615Bestrophin
IPR021134Bestrophin/UPF0187
Vocabulary: molecular function
TermDefinition
GO:0005254chloride channel activity
Vocabulary: cellular component
TermDefinition
GO:0005886plasma membrane
GO:0016020membrane
GO:0016021integral component of membrane
GO:0034707chloride channel complex
Vocabulary: biological process
TermDefinition
GO:0006810transport
GO:0006811ion transport
GO:0006821chloride transport
GO:1902476chloride transmembrane transport
InterPro
Analysis Name: Schmidtea mediteranean smed_20140614 Interproscan
Date Performed: 2020-05-01
IPR TermIPR DescriptionSourceSource TermSource DescriptionAlignment
IPR021134Bestrophin/UPF0187PFAMPF01062Bestrophincoord: 13..331
e-value: 3.5E-75
score: 253.1
IPR000615BestrophinPANTHERPTHR10736BESTROPHINcoord: 1..376
NoneNo IPR availableTMHMMTMhelixcoord: 242..264
NoneNo IPR availableTMHMMTMhelixcoord: 66..88
NoneNo IPR availableTMHMMTMhelixcoord: 24..46
NoneNo IPR availableTMHMMTMhelixcoord: 284..303