Cyclin-dependent kinase-like 1

Overview
NameCyclin-dependent kinase-like 1
Smed IDSMED30010718
Length (bp)3939
Neoblast Clusters

Zeng et. al., 2018



▻ Overview

▻ Neoblast Population

▻ Sub-lethal Irradiated Surviving X1 and X2 Cell Population

 

 

Overview

 

Single cell RNA-seq of pluripotent neoblasts and its early progenies


We isolated X1 neoblasts cells enriched in high piwi-1 expression (Neoblast Population), and profiled ∼7,614 individual cells via scRNA-seq. Unsupervised analyses uncovered 12 distinct classes from 7,088 high-quality cells. We designated these classes Nb1 to Nb12 and ordered them based on high (Nb1) to low (Nb12) piwi-1 expression levels. We further defined groups of genes that best classified the cells parsed into 12 distinct cell clusters to generate a scaled expression heat map of discriminative gene sets for each cluster. Expression of each cluster’s gene signatures was validated using multiplex fluorescence in situ hybridization (FISH) co-stained with piwi-1 and largely confirmed the cell clusters revealed by scRNA-seq.

We also tested sub-lethal irradiation exposure. To profile rare pluripotent stem cells (PSCs) and avoid interference from immediate progenitor cells, we determined a time point after sub-lethal irradiation (7 DPI) with minimal piwi-1+ cells, followed by isolation and single-cell RNA-seq of 1,200 individual cells derived from X1 (Piwi-1 high) and X2 (Piwi-1 low) cell populations (Sub-lethal Irradiated Surviving X1 and X2 Cell Population)



Explore this single cell expression dataset with our NB Cluster Shiny App



 

Neoblast Population

 

t-SNE plot shows two-dimensional representation of global gene expression relationships among all neoblasts (n = 7,088 after filter). Cluster identity was assigned based on the top 10 marker genes of each cluster (Table S2), followed by inspection of RNA in situ hybridization patterns. Neoblast groups, Nb.


Expression of Cyclin-dependent kinase-like 1 (SMED30010718) t-SNE clustered cells

Violin plots show distribution of expression levels for Cyclin-dependent kinase-like 1 (SMED30010718) in cells (dots) of each of the 12 neoblast clusters.

 

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Sub-lethal Irradiated Surviving X1 and X2 Cell Population

 

t-SNE plot of surviving X1 and X2 cells (n = 1,039 after QC filter) after sub-lethal irradiation. Colors indicate unbiased cell classification via graph-based clustering. SL, sub-lethal irradiated cell groups.

Expression of Cyclin-dependent kinase-like 1 (SMED30010718) in the t-SNE clustered sub-lethally irradiated X1 and X2 cells.

Violin plots show distribution of expression levels for Cyclin-dependent kinase-like 1 (SMED30010718) in cells (dots) of each of the 10 clusters of sub-leathally irradiated X1 and X2 cells.

 

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Embryonic Expression

Davies et. al., 2017

Hover the mouse over a column in the graph to view average RPKM values per sample.
Sort Descending | Sort Ascending | Only Non-Zero Values | Tile/Chart | Reset

Embryonic Stages: Y: yolk. S2-S8: Stages 2-8. C4: asexual adult. SX: virgin, sexually mature adult.
For further information about sample preparation and analysis for the single animal RNA-Seq experiment, please refer to the Materials and Methods

 

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Anatomical Expression

PAGE et. al., 2020



SMED30010718

has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGE



PAGE Curations: 12

  
Expressed InReference TranscriptGene ModelsPublished TranscriptTranscriptomePublicationSpecimenLifecycleEvidence
intestinal phagocyteSMED30010718SMESG000078505.1 PL05006A2G05ncbi_smed_estsPMID:23079596
Forsthoefel et al., 2012		FACS sorted cell population asexual adult cDNA to DNA expression microarray evidence
gutSMED30010718SMESG000078505.1 dd_Smed_v4_8479_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018		FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
cephalic gangliaSMED30010718SMESG000078505.1 dd_Smed_v4_8479_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018		FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
neoblastSMED30010718SMESG000078505.1 dd_Smed_v4_8479_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018		FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
gutSMED30010718SMESG000078505.1 dd_Smed_v4_8300_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018		FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
cephalic gangliaSMED30010718SMESG000078505.1 dd_Smed_v4_8300_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018		FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
Smed sexual biotypeSMED30010718SMESG000078505.1 Contig29775uc_Smed_v2PMID:29674431
Fincher et al., 2018		FACS sorted cell population adult hermaphrodite single-cell RNA-sequencing evidence
Smed sexual biotypeSMED30010718SMESG000078505.1 Contig29775newmark_estsPMID:29674431
Fincher et al., 2018		FACS sorted cell population adult hermaphrodite single-cell RNA-sequencing evidence
Smed sexual biotypeSMED30010718SMESG000061765.1 SMESG000061762.1 SMESG000078505.1 Contig55348uc_Smed_v2PMID:29674431
Fincher et al., 2018		FACS sorted cell population adult hermaphrodite single-cell RNA-sequencing evidence
Smed sexual biotypeSMED30010718SMESG000061765.1 SMESG000061762.1 SMESG000078505.1 Contig55348newmark_estsPMID:29674431
Fincher et al., 2018		FACS sorted cell population adult hermaphrodite single-cell RNA-sequencing evidence
tail regionSMED30010718SMESG000078505.1 dd_Smed_v6_8479_0_1dd_Smed_v6PMID:28171748
Stückemann et al., 2017		whole organism asexual adult RNA-sequencing evidence
intestinal phagocyteSMED30010718SMESG000078505.1 dd_Smed_v6_8479_0dd_Smed_v6PMID:29674432
Plass et al., 2018		FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
Note: Hover over icons to view figure legend
Homology
[Close]
BLAST of Cyclin-dependent kinase-like 1 vs. Ensembl Human
Match: CDKL3 (cyclin dependent kinase like 3 [Source:HGNC Symbol;Acc:HGNC:15483])

HSP 1 Score: 64.6994 bits (156), Expect = 6.165e-10
Identity = 46/141 (32.62%), Postives = 74/141 (52.48%), Query Frame = 1 
Query: 2305 QMITKIGNGSYGEVYQCKEANFDGQFVIKRFFV--PEESVREININEEIKYFKL-----LSNYRGLMRYDREICVAFSLFEESLDKKIKSYCQKSEENEKKILRVAYEILKELKELHKWEIIHRDIKHDPFLF*HQNYTKI 2706
            + + K+G GSYG V +CK  N  GQ V  + F   PE+SV +I +  EIK+ K      L N   + R  ++I + F   + ++  +++ YC   E   K++ +  ++IL+ +  LH   IIHRDIK +  L      TK+
Sbjct:    5 ETLGKVGEGSYGTVMKCKHKN-TGQIVAIKIFYERPEQSVNKIAM-REIKFLKQFHHENLVNLIEVFRQKKKIHLVFEFIDHTVLDELQHYCHGLE--SKRLRKYLFQILRAIDYLHSNNIIHRDIKPENILVSQSGITKL 141
[Close]
BLAST of Cyclin-dependent kinase-like 1 vs. Ensembl Human
Match: CDKL3 (cyclin dependent kinase like 3 [Source:HGNC Symbol;Acc:HGNC:15483])

HSP 1 Score: 64.3142 bits (155), Expect = 1.269e-9
Identity = 46/141 (32.62%), Postives = 74/141 (52.48%), Query Frame = 1 
Query: 2305 QMITKIGNGSYGEVYQCKEANFDGQFVIKRFFV--PEESVREININEEIKYFKL-----LSNYRGLMRYDREICVAFSLFEESLDKKIKSYCQKSEENEKKILRVAYEILKELKELHKWEIIHRDIKHDPFLF*HQNYTKI 2706
            + + K+G GSYG V +CK  N  GQ V  + F   PE+SV +I +  EIK+ K      L N   + R  ++I + F   + ++  +++ YC   E   K++ +  ++IL+ +  LH   IIHRDIK +  L      TK+
Sbjct:    5 ETLGKVGEGSYGTVMKCKHKN-TGQIVAIKIFYERPEQSVNKIAM-REIKFLKQFHHENLVNLIEVFRQKKKIHLVFEFIDHTVLDELQHYCHGLE--SKRLRKYLFQILRAIDYLHSNNIIHRDIKPENILVSQSGITKL 141
[Close]
BLAST of Cyclin-dependent kinase-like 1 vs. Ensembl Human
Match: CDKL3 (cyclin dependent kinase like 3 [Source:HGNC Symbol;Acc:HGNC:15483])

HSP 1 Score: 64.3142 bits (155), Expect = 1.363e-9
Identity = 46/141 (32.62%), Postives = 74/141 (52.48%), Query Frame = 1 
Query: 2305 QMITKIGNGSYGEVYQCKEANFDGQFVIKRFFV--PEESVREININEEIKYFKL-----LSNYRGLMRYDREICVAFSLFEESLDKKIKSYCQKSEENEKKILRVAYEILKELKELHKWEIIHRDIKHDPFLF*HQNYTKI 2706
            + + K+G GSYG V +CK  N  GQ V  + F   PE+SV +I +  EIK+ K      L N   + R  ++I + F   + ++  +++ YC   E   K++ +  ++IL+ +  LH   IIHRDIK +  L      TK+
Sbjct:    5 ETLGKVGEGSYGTVMKCKHKN-TGQIVAIKIFYERPEQSVNKIAM-REIKFLKQFHHENLVNLIEVFRQKKKIHLVFEFIDHTVLDELQHYCHGLE--SKRLRKYLFQILRAIDYLHSNNIIHRDIKPENILVSQSGITKL 141
[Close]
BLAST of Cyclin-dependent kinase-like 1 vs. Ensembl Celegans
Match: cdkl-1 (Cyclin-dependent kinase-like 1 [Source:UniProtKB/Swiss-Prot;Acc:Q9U2H1])

HSP 1 Score: 51.2174 bits (121), Expect = 2.862e-6
Identity = 43/165 (26.06%), Postives = 85/165 (51.52%), Query Frame = 1 
Query: 2293 LKKEQMITKIGNGSYGEVYQCKEANFDGQFVIKRFFVPEE-------SVREININEEIKYFKLLSNYRGLM---RYDREICVAFSLFEESLDKKIKSYCQKSEENEKKILRVAYEILKELKELHKWEIIHRDIKHDPFLF*HQNYTKINNGIHSVFRIIYT*KLF 2757
            + K   ++K+G GSYG VY+CK  +      IK+F   E+       ++REI + +++K+     N  GL+   + +R++ + F L + ++  +++        N++ I ++ Y++L+ LK  H  + IHRD+K +       +  K+  G     RII T +++
Sbjct:    1 MDKYDRLSKLGEGSYGVVYKCKNRDTGQIVAIKKFVETEDDPHIKKIALREIRMLKQLKH----QNLVGLIEVFKRNRKLHLVFELCDRTVLHELEK--NPHGVNDELIKKIIYQLLEALKFCHSHKCIHRDVKPENIFLTRNDQVKL--GDFGFARIINTTEMY 157
[Close]
BLAST of Cyclin-dependent kinase-like 1 vs. Ensembl Celegans
Match: cdkl-1 (Cyclin-dependent kinase-like 1 [Source:UniProtKB/Swiss-Prot;Acc:Q9U2H1])

HSP 1 Score: 51.6026 bits (122), Expect = 2.966e-6
Identity = 43/165 (26.06%), Postives = 85/165 (51.52%), Query Frame = 1 
Query: 2293 LKKEQMITKIGNGSYGEVYQCKEANFDGQFVIKRFFVPEE-------SVREININEEIKYFKLLSNYRGLM---RYDREICVAFSLFEESLDKKIKSYCQKSEENEKKILRVAYEILKELKELHKWEIIHRDIKHDPFLF*HQNYTKINNGIHSVFRIIYT*KLF 2757
            + K   ++K+G GSYG VY+CK  +      IK+F   E+       ++REI + +++K+     N  GL+   + +R++ + F L + ++  +++        N++ I ++ Y++L+ LK  H  + IHRD+K +       +  K+  G     RII T +++
Sbjct:   31 MDKYDRLSKLGEGSYGVVYKCKNRDTGQIVAIKKFVETEDDPHIKKIALREIRMLKQLKH----QNLVGLIEVFKRNRKLHLVFELCDRTVLHELEK--NPHGVNDELIKKIIYQLLEALKFCHSHKCIHRDVKPENIFLTRNDQVKL--GDFGFARIINTTEMY 187
[Close]
BLAST of Cyclin-dependent kinase-like 1 vs. Ensembl Celegans
Match: cdkl-1 (Cyclin-dependent kinase-like 1 [Source:UniProtKB/Swiss-Prot;Acc:Q9U2H1])

HSP 1 Score: 51.6026 bits (122), Expect = 3.463e-6
Identity = 45/167 (26.95%), Postives = 85/167 (50.90%), Query Frame = 1 
Query: 2293 LKKEQMITKIGNGSYGEVYQCKEANFDGQFVIKRFFVPEE-------SVREININEEIKYFKLLSNYRGLM---RYDREICVAFSLFEESLDKKIKSYCQKSEE--NEKKILRVAYEILKELKELHKWEIIHRDIKHDPFLF*HQNYTKINNGIHSVFRIIYT*KLF 2757
            + K   ++K+G GSYG VY+CK  +      IK+F   E+       ++REI + +++K+     N  GL+   + +R++ + F L     D+ +    +K+    N++ I ++ Y++L+ LK  H  + IHRD+K +       +  K+  G     RII T +++
Sbjct:  132 MDKYDRLSKLGEGSYGVVYKCKNRDTGQIVAIKKFVETEDDPHIKKIALREIRMLKQLKH----QNLVGLIEVFKRNRKLHLVFEL----CDRTVLHELEKNPHGVNDELIKKIIYQLLEALKFCHSHKCIHRDVKPENIFLTRNDQVKL--GDFGFARIINTTEMY 288
[Close]
BLAST of Cyclin-dependent kinase-like 1 vs. Ensembl Fly
Match: CG7236 (gene:FBgn0031730 transcript:FBtr0302950)

HSP 1 Score: 54.6842 bits (130), Expect = 3.942e-7
Identity = 38/161 (23.60%), Postives = 81/161 (50.31%), Query Frame = 1 
Query: 2245 IRITEHMTIHFEEMKRLKKEQMITKIGNGSYGEVYQCKEANFDGQFVIKRFFVPEE-------SVREININEEIKYFKLLSNYRGLMRYDREICVAFSLFEESLDKKIKSYCQKSEENEKKILRVAYEILKELKELHKWEIIHRDIKHDPFLF*HQNYTKI 2706
            I+  + +++  +   ++ + + ++++G GSYG VY+C++        +KRF   E+       ++REI + + +K+  L+S    + R  R + + F   E ++  +++ + Q   E+  K  ++ Y+ L  +   HK   +HRDIK +  L   Q   K+
Sbjct:   28 IKRGQCLSLRPQGSSKMDRYEKLSRLGEGSYGVVYKCRDRETGALVAVKRFVESEDDPAIRKIALREIRLLKNLKHPNLVSLLE-VFRRKRRLHLVFEFCELTVLHELERHPQGCPEHLTK--QICYQTLLGVAYCHKQGCLHRDIKPENILLTAQGQVKL 185
[Close]
BLAST of Cyclin-dependent kinase-like 1 vs. Ensembl Fly
Match: CG7236 (gene:FBgn0031730 transcript:FBtr0343388)

HSP 1 Score: 53.9138 bits (128), Expect = 7.661e-7
Identity = 37/146 (25.34%), Postives = 74/146 (50.68%), Query Frame = 1 
Query: 2290 RLKKEQMITKIGNGSYGEVYQCKEANFDGQFVIKRFFVPEE-------SVREININEEIKYFKLLSNYRGLMRYDREICVAFSLFEESLDKKIKSYCQKSEENEKKILRVAYEILKELKELHKWEIIHRDIKHDPFLF*HQNYTKI 2706
            ++ + + ++++G GSYG VY+C++        +KRF   E+       ++REI + + +K+  L+S    + R  R + + F   E ++  +++ + Q   E+  K  ++ Y+ L  +   HK   +HRDIK +  L   Q   K+
Sbjct:   20 KMDRYEKLSRLGEGSYGVVYKCRDRETGALVAVKRFVESEDDPAIRKIALREIRLLKNLKHPNLVSLLE-VFRRKRRLHLVFEFCELTVLHELERHPQGCPEHLTK--QICYQTLLGVAYCHKQGCLHRDIKPENILLTAQGQVKL 162
[Close]
BLAST of Cyclin-dependent kinase-like 1 vs. Ensembl Fly
Match: CG7236 (gene:FBgn0031730 transcript:FBtr0343389)

HSP 1 Score: 53.5286 bits (127), Expect = 8.922e-7
Identity = 37/146 (25.34%), Postives = 74/146 (50.68%), Query Frame = 1 
Query: 2290 RLKKEQMITKIGNGSYGEVYQCKEANFDGQFVIKRFFVPEE-------SVREININEEIKYFKLLSNYRGLMRYDREICVAFSLFEESLDKKIKSYCQKSEENEKKILRVAYEILKELKELHKWEIIHRDIKHDPFLF*HQNYTKI 2706
            ++ + + ++++G GSYG VY+C++        +KRF   E+       ++REI + + +K+  L+S    + R  R + + F   E ++  +++ + Q   E+  K  ++ Y+ L  +   HK   +HRDIK +  L   Q   K+
Sbjct:   29 KMDRYEKLSRLGEGSYGVVYKCRDRETGALVAVKRFVESEDDPAIRKIALREIRLLKNLKHPNLVSLLE-VFRRKRRLHLVFEFCELTVLHELERHPQGCPEHLTK--QICYQTLLGVAYCHKQGCLHRDIKPENILLTAQGQVKL 171
[Close]
BLAST of Cyclin-dependent kinase-like 1 vs. Ensembl Fly
Match: CG7236 (gene:FBgn0031730 transcript:FBtr0343387)

HSP 1 Score: 53.5286 bits (127), Expect = 1.093e-6
Identity = 37/146 (25.34%), Postives = 74/146 (50.68%), Query Frame = 1 
Query: 2290 RLKKEQMITKIGNGSYGEVYQCKEANFDGQFVIKRFFVPEE-------SVREININEEIKYFKLLSNYRGLMRYDREICVAFSLFEESLDKKIKSYCQKSEENEKKILRVAYEILKELKELHKWEIIHRDIKHDPFLF*HQNYTKI 2706
            ++ + + ++++G GSYG VY+C++        +KRF   E+       ++REI + + +K+  L+S    + R  R + + F   E ++  +++ + Q   E+  K  ++ Y+ L  +   HK   +HRDIK +  L   Q   K+
Sbjct:   46 KMDRYEKLSRLGEGSYGVVYKCRDRETGALVAVKRFVESEDDPAIRKIALREIRLLKNLKHPNLVSLLE-VFRRKRRLHLVFEFCELTVLHELERHPQGCPEHLTK--QICYQTLLGVAYCHKQGCLHRDIKPENILLTAQGQVKL 188
[Close]
BLAST of Cyclin-dependent kinase-like 1 vs. Ensembl Fly
Match: Ask1 (gene:FBgn0014006 transcript:FBtr0300256)

HSP 1 Score: 51.6026 bits (122), Expect = 5.789e-6
Identity = 50/172 (29.07%), Postives = 84/172 (48.84%), Query Frame = 1 
Query: 2188 IEKDLLYFVNYDKRDLNIPIRITEHMTIHFEEMKRLKKEQMITKIGNGSYGEVYQCKEANFDGQFVIKRFFVPEESVREIN-INEEIKYFKLLSNYRGLMRYDREICVA--FSLFEE-----SLDKKIKSYCQKSEENEKKILRVAYEILKELKELHKWEIIHRDIKHDPFL 2679
            +  D + FVN    D NI           ++E  R    +M+  +G G+YG VY  ++     +  IK   VPE++ +++  ++EEIK    L  +R ++RY         F +F E     SL   +++     ++NE  +   + +IL+ LK LH+ +I+HRDIK D  L
Sbjct:  559 MTADQVVFVNLSNDDANI------EYEYDYDEQNR----KMV--LGKGTYGTVYAARDKQTQVRIAIKE--VPEKNSQDVQPLHEEIKLHSQL-RHRNIVRYLGSCSENGFFKIFMEQVPGGSLSDLLETKWGPLKDNESTMAFYSKQILEGLKYLHEQDIVHRDIKGDNVL 715
[Close]
BLAST of Cyclin-dependent kinase-like 1 vs. Ensembl Zebrafish
Match: cdk21 (cyclin-dependent kinase 21 [Source:ZFIN;Acc:ZDB-GENE-131121-149])

HSP 1 Score: 55.0694 bits (131), Expect = 2.784e-7
Identity = 45/168 (26.79%), Postives = 85/168 (50.60%), Query Frame = 1 
Query: 2305 QMITKIGNGSYGEVYQCKEANFDGQFV-IKRFFVPEES--------VREININEEIKYF------KLLSNYRGLMRYDREICVAFSLFEESLDKKIKSYCQKSEEN---EKKILRVAYEILKELKELHKWEIIHRDIKHDPFLF*HQNYTKINN-GIHSV--FRIIYT 2745
            +++ +IG G+YG+VY+ +E     + + +KR  +PEE         +RE+ +  +I++F      KL+S   G   +  ++ + F    E +D+ + ++  ++ E    + KI  V  ++L  L  LH   +IHRD+K D  L   +   KI + G+  +  +RI  T
Sbjct:   12 EILAEIGQGAYGKVYKAREKREQQRLIAVKRLNIPEEPESGIPQFMIREVALLRKIEHFNHPNIVKLMSVSAGWQNHKFDMTLVF----EYIDQDLTTFLSRASEKGLAKDKIKDVMRQLLSGLDFLHTNSVIHRDLKPDNVLVSSRGEVKIADFGLARIYTYRIALT 175
[Close]
BLAST of Cyclin-dependent kinase-like 1 vs. Ensembl Zebrafish
Match: cdk6 (cyclin-dependent kinase 6 [Source:ZFIN;Acc:ZDB-GENE-060503-786])

HSP 1 Score: 54.6842 bits (130), Expect = 3.038e-7
Identity = 37/134 (27.61%), Postives = 72/134 (53.73%), Query Frame = 1 
Query: 2311 ITKIGNGSYGEVYQCKEANFDGQFV-IKRFFV-------PEESVREININEEIKYFKLLSNYR-----GLMRYDREICVAFSLFEESLDKKIKSYCQKSEE---NEKKILRVAYEILKELKELHKWEIIHRDIK 2664
            + +IG G+YG+VY+ ++    G+FV +KR  V       P  ++RE+ +  +++ F+  +  R      + R DRE     +L  E +D+ + +Y +K+ +     + I  + Y++L+ L  LH   ++HRD+K
Sbjct:   13 VAEIGEGAYGKVYKARDLKNGGRFVALKRVRVQTEEEGMPLSTIREVAVLRQLESFEHPNVVRLFDVCTVSRTDRE--TKLTLVFEHVDQDLTTYLEKAPDPGVPPETIKDMMYQLLQGLDFLHSHRVVHRDLK 144
[Close]
BLAST of Cyclin-dependent kinase-like 1 vs. Ensembl Zebrafish
Match: cdk6 (cyclin-dependent kinase 6 [Source:ZFIN;Acc:ZDB-GENE-060503-786])

HSP 1 Score: 55.0694 bits (131), Expect = 3.298e-7
Identity = 37/134 (27.61%), Postives = 72/134 (53.73%), Query Frame = 1 
Query: 2311 ITKIGNGSYGEVYQCKEANFDGQFV-IKRFFV-------PEESVREININEEIKYFKLLSNYR-----GLMRYDREICVAFSLFEESLDKKIKSYCQKSEE---NEKKILRVAYEILKELKELHKWEIIHRDIK 2664
            + +IG G+YG+VY+ ++    G+FV +KR  V       P  ++RE+ +  +++ F+  +  R      + R DRE     +L  E +D+ + +Y +K+ +     + I  + Y++L+ L  LH   ++HRD+K
Sbjct:   13 VAEIGEGAYGKVYKARDLKNGGRFVALKRVRVQTEEEGMPLSTIREVAVLRQLESFEHPNVVRLFDVCTVSRTDRE--TKLTLVFEHVDQDLTTYLEKAPDPGVPPETIKDMMYQLLQGLDFLHSHRVVHRDLK 144
[Close]
BLAST of Cyclin-dependent kinase-like 1 vs. Ensembl Mouse
Match: Cdkl3 (cyclin-dependent kinase-like 3 [Source:MGI Symbol;Acc:MGI:2388268])

HSP 1 Score: 60.8474 bits (146), Expect = 8.757e-10
Identity = 44/140 (31.43%), Postives = 73/140 (52.14%), Query Frame = 1 
Query: 2305 QMITKIGNGSYGEVYQCKEANFDGQFVIKRFF-VPEESVREININEEIKYFKL-----LSNYRGLMRYDREICVAFSLFEESLDKKIKSYCQKSEENEKKILRVAYEILKELKELHKWEIIHRDIKHDPFLF*HQNYTKI 2706
            + + K+G GSYG V +CK  +      IK F+  PE+SV +I    EIK+ K      L N   + R  ++I + F   + ++  +++ YC   E   K++ +  ++IL+ ++ LH   IIHRDIK +  L      TK+
Sbjct:    5 ETLGKVGEGSYGTVMKCKHKDTGRIVAIKIFYEKPEKSVNKIA-TREIKFLKQFRHENLVNLIEVFRQKKKIHLVFEFIDHTVLDELQHYCHGLES--KRLRKYLFQILRAIEYLHNNNIIHRDIKPENILVSQSGITKL 141
[Close]
BLAST of Cyclin-dependent kinase-like 1 vs. Ensembl Mouse
Match: Cdkl3 (cyclin-dependent kinase-like 3 [Source:MGI Symbol;Acc:MGI:2388268])

HSP 1 Score: 61.2326 bits (147), Expect = 3.811e-9
Identity = 44/140 (31.43%), Postives = 73/140 (52.14%), Query Frame = 1 
Query: 2305 QMITKIGNGSYGEVYQCKEANFDGQFVIKRFF-VPEESVREININEEIKYFKL-----LSNYRGLMRYDREICVAFSLFEESLDKKIKSYCQKSEENEKKILRVAYEILKELKELHKWEIIHRDIKHDPFLF*HQNYTKI 2706
            + + K+G GSYG V +CK  +      IK F+  PE+SV +I    EIK+ K      L N   + R  ++I + F   + ++  +++ YC   E   K++ +  ++IL+ ++ LH   IIHRDIK +  L      TK+
Sbjct:    5 ETLGKVGEGSYGTVMKCKHKDTGRIVAIKIFYEKPEKSVNKI-ATREIKFLKQFRHENLVNLIEVFRQKKKIHLVFEFIDHTVLDELQHYCHGLES--KRLRKYLFQILRAIEYLHNNNIIHRDIKPENILVSQSGITKL 141
[Close]
BLAST of Cyclin-dependent kinase-like 1 vs. Ensembl Mouse
Match: Cdkl3 (cyclin-dependent kinase-like 3 [Source:MGI Symbol;Acc:MGI:2388268])

HSP 1 Score: 61.2326 bits (147), Expect = 3.811e-9
Identity = 44/140 (31.43%), Postives = 73/140 (52.14%), Query Frame = 1 
Query: 2305 QMITKIGNGSYGEVYQCKEANFDGQFVIKRFF-VPEESVREININEEIKYFKL-----LSNYRGLMRYDREICVAFSLFEESLDKKIKSYCQKSEENEKKILRVAYEILKELKELHKWEIIHRDIKHDPFLF*HQNYTKI 2706
            + + K+G GSYG V +CK  +      IK F+  PE+SV +I    EIK+ K      L N   + R  ++I + F   + ++  +++ YC   E   K++ +  ++IL+ ++ LH   IIHRDIK +  L      TK+
Sbjct:    5 ETLGKVGEGSYGTVMKCKHKDTGRIVAIKIFYEKPEKSVNKI-ATREIKFLKQFRHENLVNLIEVFRQKKKIHLVFEFIDHTVLDELQHYCHGLES--KRLRKYLFQILRAIEYLHNNNIIHRDIKPENILVSQSGITKL 141
[Close]
BLAST of Cyclin-dependent kinase-like 1 vs. Ensembl Mouse
Match: Cdkl3 (cyclin-dependent kinase-like 3 [Source:MGI Symbol;Acc:MGI:2388268])

HSP 1 Score: 61.6178 bits (148), Expect = 4.683e-9
Identity = 44/140 (31.43%), Postives = 73/140 (52.14%), Query Frame = 1 
Query: 2305 QMITKIGNGSYGEVYQCKEANFDGQFVIKRFF-VPEESVREININEEIKYFKL-----LSNYRGLMRYDREICVAFSLFEESLDKKIKSYCQKSEENEKKILRVAYEILKELKELHKWEIIHRDIKHDPFLF*HQNYTKI 2706
            + + K+G GSYG V +CK  +      IK F+  PE+SV +I    EIK+ K      L N   + R  ++I + F   + ++  +++ YC   E   K++ +  ++IL+ ++ LH   IIHRDIK +  L      TK+
Sbjct:    5 ETLGKVGEGSYGTVMKCKHKDTGRIVAIKIFYEKPEKSVNKI-ATREIKFLKQFRHENLVNLIEVFRQKKKIHLVFEFIDHTVLDELQHYCHGLES--KRLRKYLFQILRAIEYLHNNNIIHRDIKPENILVSQSGITKL 141
[Close]
BLAST of Cyclin-dependent kinase-like 1 vs. Ensembl Mouse
Match: Cdkl3 (cyclin-dependent kinase-like 3 [Source:MGI Symbol;Acc:MGI:2388268])

HSP 1 Score: 61.2326 bits (147), Expect = 7.667e-9
Identity = 44/140 (31.43%), Postives = 73/140 (52.14%), Query Frame = 1 
Query: 2305 QMITKIGNGSYGEVYQCKEANFDGQFVIKRFF-VPEESVREININEEIKYFKL-----LSNYRGLMRYDREICVAFSLFEESLDKKIKSYCQKSEENEKKILRVAYEILKELKELHKWEIIHRDIKHDPFLF*HQNYTKI 2706
            + + K+G GSYG V +CK  +      IK F+  PE+SV +I    EIK+ K      L N   + R  ++I + F   + ++  +++ YC   E   K++ +  ++IL+ ++ LH   IIHRDIK +  L      TK+
Sbjct:    5 ETLGKVGEGSYGTVMKCKHKDTGRIVAIKIFYEKPEKSVNKI-ATREIKFLKQFRHENLVNLIEVFRQKKKIHLVFEFIDHTVLDELQHYCHGLES--KRLRKYLFQILRAIEYLHNNNIIHRDIKPENILVSQSGITKL 141
[Close]
BLAST of Cyclin-dependent kinase-like 1 vs. UniProt/SwissProt
Match: sp|Q4R8T9|CDKL3_MACFA (Cyclin-dependent kinase-like 3 OS=Macaca fascicularis OX=9541 GN=CDKL3 PE=2 SV=1)

HSP 1 Score: 64.3142 bits (155), Expect = 5.690e-9
Identity = 46/141 (32.62%), Postives = 74/141 (52.48%), Query Frame = 1 
Query: 2305 QMITKIGNGSYGEVYQCKEANFDGQFVIKRFFV--PEESVREININEEIKYFKL-----LSNYRGLMRYDREICVAFSLFEESLDKKIKSYCQKSEENEKKILRVAYEILKELKELHKWEIIHRDIKHDPFLF*HQNYTKI 2706
            + + K+G GSYG V +CK  N  GQ V  + F   PE+SV +I +  EIK+ K      L N   + R  ++I + F   + ++  +++ YC   E   K++ +  ++IL+ +  LH   IIHRDIK +  L      TK+
Sbjct:    5 ETLGKVGEGSYGTVMKCKHKN-TGQIVAIKIFYERPEQSVNKIAM-REIKFLKQFHHENLVNLIEVFRQKKKIHLVFEFIDHTVLDELQHYCHGLE--SKRLRKYLFQILRAIDYLHSNNIIHRDIKPENILVSQSGITKL 141
[Close]
BLAST of Cyclin-dependent kinase-like 1 vs. UniProt/SwissProt
Match: sp|Q8IVW4|CDKL3_HUMAN (Cyclin-dependent kinase-like 3 OS=Homo sapiens OX=9606 GN=CDKL3 PE=1 SV=1)

HSP 1 Score: 64.3142 bits (155), Expect = 6.545e-9
Identity = 46/141 (32.62%), Postives = 74/141 (52.48%), Query Frame = 1 
Query: 2305 QMITKIGNGSYGEVYQCKEANFDGQFVIKRFFV--PEESVREININEEIKYFKL-----LSNYRGLMRYDREICVAFSLFEESLDKKIKSYCQKSEENEKKILRVAYEILKELKELHKWEIIHRDIKHDPFLF*HQNYTKI 2706
            + + K+G GSYG V +CK  N  GQ V  + F   PE+SV +I +  EIK+ K      L N   + R  ++I + F   + ++  +++ YC   E   K++ +  ++IL+ +  LH   IIHRDIK +  L      TK+
Sbjct:    5 ETLGKVGEGSYGTVMKCKHKN-TGQIVAIKIFYERPEQSVNKIAM-REIKFLKQFHHENLVNLIEVFRQKKKIHLVFEFIDHTVLDELQHYCHGLE--SKRLRKYLFQILRAIDYLHSNNIIHRDIKPENILVSQSGITKL 141
[Close]
BLAST of Cyclin-dependent kinase-like 1 vs. UniProt/SwissProt
Match: sp|Q9JM01|CDKL3_RAT (Cyclin-dependent kinase-like 3 OS=Rattus norvegicus OX=10116 GN=Cdkl3 PE=1 SV=2)

HSP 1 Score: 61.2326 bits (147), Expect = 5.780e-8
Identity = 44/140 (31.43%), Postives = 73/140 (52.14%), Query Frame = 1 
Query: 2305 QMITKIGNGSYGEVYQCKEANFDGQFVIKRFF-VPEESVREININEEIKYFKL-----LSNYRGLMRYDREICVAFSLFEESLDKKIKSYCQKSEENEKKILRVAYEILKELKELHKWEIIHRDIKHDPFLF*HQNYTKI 2706
            + + K+G GSYG V +CK  +      IK F+  PE+SV +I    EIK+ K      L N   + R  ++I + F   + ++  +++ YC   E   K++ +  ++IL+ ++ LH   IIHRDIK +  L      TK+
Sbjct:    5 ETLGKVGEGSYGTVMKCKHKDTGRIVAIKIFYEKPEKSVNKI-ATREIKFLKQFRHENLVNLIEVFRQKKKIHLVFEFIDHTVLDELQHYCHGLES--KRLRKYLFQILRAIEYLHNNNIIHRDIKPENILVSQSGITKL 141
[Close]
BLAST of Cyclin-dependent kinase-like 1 vs. UniProt/SwissProt
Match: sp|Q8BLF2|CDKL3_MOUSE (Cyclin-dependent kinase-like 3 OS=Mus musculus OX=10090 GN=Cdkl3 PE=2 SV=2)

HSP 1 Score: 60.8474 bits (146), Expect = 6.759e-8
Identity = 44/140 (31.43%), Postives = 73/140 (52.14%), Query Frame = 1 
Query: 2305 QMITKIGNGSYGEVYQCKEANFDGQFVIKRFF-VPEESVREININEEIKYFKL-----LSNYRGLMRYDREICVAFSLFEESLDKKIKSYCQKSEENEKKILRVAYEILKELKELHKWEIIHRDIKHDPFLF*HQNYTKI 2706
            + + K+G GSYG V +CK  +      IK F+  PE+SV +I    EIK+ K      L N   + R  ++I + F   + ++  +++ YC   E   K++ +  ++IL+ ++ LH   IIHRDIK +  L      TK+
Sbjct:    5 ETLGKVGEGSYGTVMKCKHKDTGRIVAIKIFYEKPEKSVNKI-ATREIKFLKQFRHENLVNLIEVFRQKKKIHLVFEFIDHTVLDELQHYCHGLES--KRLRKYLFQILRAIEYLHNNNIIHRDIKPENILVSQSGITKL 141
[Close]
BLAST of Cyclin-dependent kinase-like 1 vs. UniProt/SwissProt
Match: sp|P34112|CDK1_DICDI (Cyclin-dependent kinase 1 OS=Dictyostelium discoideum OX=44689 GN=cdk1 PE=2 SV=1)

HSP 1 Score: 52.7582 bits (125), Expect = 9.407e-6
Identity = 40/146 (27.40%), Postives = 71/146 (48.63%), Query Frame = 1 
Query: 2293 LKKEQMITKIGNGSYGEVYQCKEANFDGQFVIKRF-----FVPEESVREININEEIKYFKLLSNYRGLMRYDREICVAFSLFEESLDKKIKSYCQKSEENEKKILRV-AYEILKELKELHKWEIIHRDIKHDPFLF*HQNYTKINN 2712
            L + Q + K+G G+YG+VY+ KE        +K+       VP  ++REI++ +E+ +  ++S +  L   +R       L  E LD+ +K Y         ++++   Y++LK L   H   I+HRD+K    L   Q   K+ +
Sbjct:    7 LSRYQKLEKLGEGTYGKVYKAKEKATGRMVALKKIRLEDDGVPSTALREISLLKEVPHPNVVSLFDVLHCQNR-----LYLVFEYLDQDLKKYMDSVPALCPQLIKSYLYQLLKGLAYSHGHRILHRDLKPQNLLIDRQGALKLAD 147
[Close]
BLAST of Cyclin-dependent kinase-like 1 vs. TrEMBL
Match: A0A2B4R8T7 (Zinc finger MYM-type protein 1 OS=Stylophora pistillata OX=50429 GN=ZMYM1 PE=4 SV=1)

HSP 1 Score: 116.701 bits (291), Expect = 6.126e-32
Identity = 61/148 (41.22%), Postives = 88/148 (59.46%), Query Frame = 2 
Query:  185 AHMSVIHTSLAARMKESSPR*IYVYSYAHRLNLSLLSALEKVDPF*SMKGILQSLHNFLAASPKYLAVFKNARVDSNRISLTIKSIISATRWSCDWEAVRSLTEQFSSLCKALLVLADSKDFDTYTGSHGPLINMCKFGFALGLLVLK 628
            A M  +H  L+ RM+E S   IYV+ Y + LNL+L   + +++   +  G +Q+L+NFL A+PK  A+F +  V    + LT+KS +S TRWSC WEA +++ EQ   + KALL L+  KD  TY+ S   L  +C   F  GL VLK
Sbjct:  238 ADMKGVHKGLSTRMEECSLLCIYVHCYGYVLNLALQDTMTQIETLRNALGTIQALYNFLEANPKRHALFSDTEVQGEDLKLTLKS-LSTTRWSCRWEAAKAVHEQMERIVKALLTLSSDKDPKTYSESRALLNAICDLEFVFGLCVLK 384

HSP 2 Score: 53.5286 bits (127), Expect = 6.126e-32
Identity = 29/60 (48.33%), Postives = 40/60 (66.67%), Query Frame = 3 
Query:    3 RTEQVAVFLKYVLDGKTVESFVGVFETTSTEGDVLYALVKDIITSLCLRDQDIVEECFDG 182
            RTEQV++ L + L+G   E+F+G + T STEG+V   LVK  IT L L  ++IV + FDG
Sbjct:  180 RTEQVSLCLSFALNGTKKEAFIGFYSTKSTEGEV---LVKSAITELNLDLKNIVGKAFDG 236
[Close]
BLAST of Cyclin-dependent kinase-like 1 vs. TrEMBL
Match: A0A2B4R829 (Zinc finger MYM-type protein 1 OS=Stylophora pistillata OX=50429 GN=ZMYM1 PE=4 SV=1)

HSP 1 Score: 107.842 bits (268), Expect = 1.185e-28
Identity = 67/195 (34.36%), Postives = 104/195 (53.33%), Query Frame = 2 
Query:  185 AHMSVIHTSLAARMKESSPR*IYVYSYAHRLNLSLLSALEKVDPF*SMKGILQSLHNFLAASPKYLAVFKNARVDSNRISLTIKSIISATRWSCDWEAVRSLTEQFSSLCKALLVLADSKDFDTYTGSHGPLINMCKFGFALGLLVLK--------*CY----QT*VPITTRRNTELNIVTLLLIRNKEMIKTFF 733
            A+++ +   L+ RM+E SP  IYV+   H LNL+L   + +++P  +  G +Q+L+NFL ASPK   +F +  V    + LT+ S ++  RWSC WEA ++      + CK+LL+ +  KD  TY+ S      +C   F  GL VLK         C     +T   I+ RRN +L I TL   R++E  K+ +
Sbjct:  184 ANVNGVPKGLSTRMEECSPLGIYVHCCRHVLNLALQDTMTQIEPLRNALGTIQALYNFLEASPKRHTLFNDTEVQGKDLKLTLNS-LTTIRWSCRWEAAKA----NGTDCKSLLIQSSDKDPKTYSESRALFNAICDLEFVFGLCVLKVILCSTNSLCRYLQGKTVDVISARRNADLTIQTLRQCRSEESFKSVW 373

HSP 2 Score: 50.8322 bits (120), Expect = 1.185e-28
Identity = 24/51 (47.06%), Postives = 34/51 (66.67%), Query Frame = 3 
Query:   30 KYVLDGKTVESFVGVFETTSTEGDVLYALVKDIITSLCLRDQDIVEECFDG 182
             + L+G   E+F+G++ T STEG+VLY LVK  IT L    ++IV + FDG
Sbjct:  132 NFALNGTKKEAFIGLYSTKSTEGEVLYELVKSAITELNHDLKNIVAKAFDG 182
[Close]
BLAST of Cyclin-dependent kinase-like 1 vs. TrEMBL
Match: A0A2B4RLJ7 (Zinc finger MYM-type protein 1 OS=Stylophora pistillata OX=50429 GN=ZMYM1 PE=4 SV=1)

HSP 1 Score: 116.701 bits (291), Expect = 2.309e-25
Identity = 71/182 (39.01%), Postives = 100/182 (54.95%), Query Frame = 2 
Query:  224 MKESSPR*IYVYSYAHRLNLSLLSALEKVDPF*SMKGILQSLHNFLAASPKYLAVFKNARVDSNRISLTIKSIISATRWSCDWEAVRSLTEQFSSLCKALLVLADSKDFDTYTGSHGPLINMCKFGFALGLLVLK--------*CY----QT*VPITTRRNTELNIVTLLLIRNKEMIKTFF 733
            M+E SP  IYV+ Y H LNL+L   + +++P  +  G  Q+L+NFL ASPK  A+F +  +    + LT+KS +S TRWSC WEA +++  Q   + KALL L+  KD  TY+ S   L  +C   F  GL VLK         C     +T   I+ RRN  L I TL   R++E  K+ +
Sbjct:    1 MEECSPLGIYVHCYGHVLNLALKDTVTQIEPLRNALGTFQALYNFLEASPKRHALFSDTDMQGEDLKLTLKS-LSTTRWSCWWEAAKAVHGQMERIVKALLTLSSDKDPKTYSESRALLNAICDLEFVFGLCVLKVILSNTSSLCRYLQGKTVDVISARRNANLTIQTLRQCRSEESFKSVW 181
[Close]
BLAST of Cyclin-dependent kinase-like 1 vs. TrEMBL
Match: A0A3M6TPX8 (Dimer_Tnp_hAT domain-containing protein OS=Pocillopora damicornis OX=46731 GN=pdam_00001966 PE=4 SV=1)

HSP 1 Score: 118.627 bits (296), Expect = 2.621e-24
Identity = 64/146 (43.84%), Postives = 90/146 (61.64%), Query Frame = 2 
Query:  191 MSVIHTSLAARMKESSPR*IYVYSYAHRLNLSLLSALEKVDPF*SMKGILQSLHNFLAASPKYLAVFKNARVDSNRISLTIKSIISATRWSCDWEAVRSLTEQFSSLCKALLVLADSKDFDTYTGSHGPLINMCKFGFALGLLVLK 628
            MS I  SLA R KE SP  IYV+ Y H L+L+L   + +++   +  G +QSL+NFL  S K  A+FK+  V    ++LT+KS +S TRWSC W AVR++ EQ   +  AL+ L+  +D  TY  S+  L ++C F F  GL+VLK
Sbjct:    1 MSGIRKSLATRTKECSPLGIYVHCYGHLLHLALQDTMTEIETLRNALGTIQSLYNFLHGSTKRHALFKDIEVHEEDVALTLKS-LSTTRWSCRWAAVRAVLEQVPRIMAALVTLSKDRDPKTYNESYSLLHSICDFQFVYGLMVLK 145

HSP 2 Score: 102.834 bits (255), Expect = 4.536e-19
Identity = 55/102 (53.92%), Postives = 65/102 (63.73%), Query Frame = 3 
Query:  882 RSTTVDIVNDMLLQGLHEILHIFYKLSSTFDAIPATSCSVERDFSGLRRI*AYFCSKM*QDCLKSIALINIEQGYAICLLQEVMETIIDIFGRL*NRNSYFF 1187
            R     IV  M   GLH+IL + YK++S    IPATSCS ER FS LRRI  +  S M QD L SIA+INIE+ YA   +Q  M+ IIDIFG   NR+SYFF
Sbjct:  322 RKNAAVIVKTMHQNGLHDILPVLYKVASILARIPATSCSAERSFSALRRIKTFLRSTMGQDRLSSIAVINIERKYANKTMQNDMQRIIDIFGSRSNRSSYFF 423
[Close]
BLAST of Cyclin-dependent kinase-like 1 vs. TrEMBL
Match: A0A2B4S5U5 (MICOS complex subunit MIC60 OS=Stylophora pistillata OX=50429 GN=TTC28 PE=3 SV=1)

HSP 1 Score: 83.5741 bits (205), Expect = 8.709e-24
Identity = 40/102 (39.22%), Postives = 63/102 (61.76%), Query Frame = 2 
Query:  185 AHMSVIHTSLAARMKESSPR*IYVYSYAHRLNLSLLSALEKVDPF*SMKGILQSLHNFLAASPKYLAVFKNARVDSNRISLTIKSIISATRWSCDWEAVRSL 490
            A+M  +H  L+ +M+E S   IYV+ Y H LNL+L   + + +P  +  G +Q+L+N L A PK  A+F +  V    + LT+KS +S TRW+C WEA +++
Sbjct:  744 ANMDGVHKELSTKMEECSRLGIYVHCYGHMLNLALQDTMIQTEPLRNALGTIQALYNVLEARPKRHALFSDIEVQGEDLKLTLKS-LSTTRWTCRWEAAKAV 844

HSP 2 Score: 58.9214 bits (141), Expect = 8.709e-24
Identity = 28/60 (46.67%), Postives = 41/60 (68.33%), Query Frame = 3 
Query:    3 RTEQVAVFLKYVLDGKTVESFVGVFETTSTEGDVLYALVKDIITSLCLRDQDIVEECFDG 182
            RTE+V++ L + L+G   E+F+G + T STEG+VL+ LV+  IT L L  +DI  + FDG
Sbjct:  683 RTEKVSLCLSFALNGTMKEAFIGFYSTKSTEGEVLFELVESAITELNLDLKDIFGKAFDG 742
[Close]
BLAST of Cyclin-dependent kinase-like 1 vs. Ensembl Cavefish
Match: cdk6 (cyclin dependent kinase 6 [Source:NCBI gene;Acc:103047757])

HSP 1 Score: 55.4546 bits (132), Expect = 2.047e-7
Identity = 37/140 (26.43%), Postives = 76/140 (54.29%), Query Frame = 1 
Query: 2293 LKKEQMITKIGNGSYGEVYQCKEANFDGQFV-IKRFFV-------PEESVREININEEIKYFKLLSNYR-----GLMRYDREICVAFSLFEESLDKKIKSYCQKSEE---NEKKILRVAYEILKELKELHKWEIIHRDIK 2664
            +++ + + +IG G+YG+VY+ ++    G+FV +KR  V       P  ++RE+ +  +++ F+  +  R      + R DRE     +L  E +D+ + +Y +K+ +     + I  + Y++L+ L  LH   ++HRD+K
Sbjct:    7 IQQYEPVAEIGEGAYGKVYKARDLKNGGRFVALKRVRVQTEEEGMPLSTIREVAVLRQLESFEHPNVVRLFDVCTVSRTDRE--TKLTLVFEHVDQDLTTYLEKAPDPGVPPETIKDMMYQLLQGLDFLHSHRVVHRDLK 144
[Close]
BLAST of Cyclin-dependent kinase-like 1 vs. Ensembl Cavefish
Match: cdk4 (cyclin dependent kinase 4 [Source:NCBI gene;Acc:103034254])

HSP 1 Score: 50.447 bits (119), Expect = 7.024e-6
Identity = 39/157 (24.84%), Postives = 77/157 (49.04%), Query Frame = 1 
Query: 2311 ITKIGNGSYGEVYQCKEANFDGQFVIKRFF--------VPEESVREININEEIKYFK-----LLSNYRGLMRYDREICVAFSLFEESLDKKIKSYCQKSEENEKKILRV---AYEILKELKELHKWEIIHRDIKHDPFLF*HQNYTKINN-GIHSVF 2730
            + +IG G+YG VY+ ++    GQFV  +          +P  +VRE+ + + ++ F       L +    +R D+E  V  +L  E +D+ +K+Y +K+      + R+     ++L  L  LH   ++HRD+K +  L   +   K+ + G+  ++
Sbjct:   14 VAEIGGGAYGTVYKARDTQ-SGQFVALKSVRVQTDQEGLPLSTVREVALLKRLEQFDHPNIVKLMDVCATLRTDQETKV--TLVFEHVDQDLKTYLEKAPAPGLPVSRIKDLMQQLLCGLSFLHSNRVLHRDLKPENILVTSRGQVKLADFGLARIY 167
[Close]
BLAST of Cyclin-dependent kinase-like 1 vs. Ensembl Cavefish
Match: ENSAMXT00000057054.1 (cyclin-dependent kinase-like 1 [Source:NCBI gene;Acc:103024925])

HSP 1 Score: 50.0618 bits (118), Expect = 9.942e-6
Identity = 35/137 (25.55%), Postives = 71/137 (51.82%), Query Frame = 1 
Query: 2293 LKKEQMITKIGNGSYGEVYQCKEANFDGQFVIKRFFVPEE-------SVREININEEIKYFKLLSNYRGLMRYDREICVAFSLFEESLDKKIKSYCQKSEENEKKILRVAYEILKELKELHKWEIIHRDIKHDPFLF 2682
            ++K + + KIG GSYG V++C+  +      IK+F   E+       ++REI + +++K+  L+ N   + R  R + + F   E+++  ++  + +   E + K   + ++ L+ +   HK   IHRD+K +  L 
Sbjct:    1 MEKYEKLAKIGEGSYGVVFKCRNRDTGQIVAIKKFVESEDDPVIKKIALREIRMLKQLKHVNLV-NLLEVFRRKRRLHLVFEFCEQTVLNELDKHPKGVPEAQLK--SIIWQTLQAVNFCHKNNCIHRDVKPENILL 134
[Close]
BLAST of Cyclin-dependent kinase-like 1 vs. Ensembl Cavefish
Match: ENSAMXT00000052448.1 (cyclin-dependent kinase-like 1 [Source:NCBI gene;Acc:103024925])

HSP 1 Score: 50.0618 bits (118), Expect = 9.942e-6
Identity = 35/137 (25.55%), Postives = 71/137 (51.82%), Query Frame = 1 
Query: 2293 LKKEQMITKIGNGSYGEVYQCKEANFDGQFVIKRFFVPEE-------SVREININEEIKYFKLLSNYRGLMRYDREICVAFSLFEESLDKKIKSYCQKSEENEKKILRVAYEILKELKELHKWEIIHRDIKHDPFLF 2682
            ++K + + KIG GSYG V++C+  +      IK+F   E+       ++REI + +++K+  L+ N   + R  R + + F   E+++  ++  + +   E + K   + ++ L+ +   HK   IHRD+K +  L 
Sbjct:    1 MEKYEKLAKIGEGSYGVVFKCRNRDTGQIVAIKKFVESEDDPVIKKIALREIRMLKQLKHVNLV-NLLEVFRRKRRLHLVFEFCEQTVLNELDKHPKGVPEAQLK--SIIWQTLQAVNFCHKNNCIHRDVKPENILL 134
[Close]
BLAST of Cyclin-dependent kinase-like 1 vs. Ensembl Sea Lamprey
Match: cdk4 (cyclin-dependent kinase 4 [Source:ZFIN;Acc:ZDB-GENE-060929-974])

HSP 1 Score: 51.6026 bits (122), Expect = 7.423e-7
Identity = 40/141 (28.37%), Postives = 73/141 (51.77%), Query Frame = 1 
Query: 2290 RLKKEQMITKIGNGSYGEVYQCKEANFDGQFV-IKRFFV-------PEESVREININEEIKYFKLLSNYR-----GLMRYDREICVAFSLFEESLDKKIKSYCQKSEE---NEKKILRVAYEILKELKELHKWEIIHRDIK 2664
            RL+ E  I +IG G+YG VY+ ++   +G+FV +K+  V       P  ++RE+ +  +++ F+  +  R        R DRE     +L  E +D+ + +Y +K+        KI  + +++L  L  LH   ++HRD+K
Sbjct:   12 RLQYEP-IAEIGVGAYGTVYKARDLQNEGRFVALKKVRVQTGEEGMPLSTIREVALLRQLETFEHPNVVRLFDVCATSRTDRE--TRLTLVFEHVDQDLSTYLEKAPAPGLPADKIKDMMHQLLSGLDFLHTHRVVHRDLK 149
[Close]
BLAST of Cyclin-dependent kinase-like 1 vs. Ensembl Nematostella
Match: EDO37567 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7SFE6])

HSP 1 Score: 59.3066 bits (142), Expect = 4.233e-9
Identity = 49/159 (30.82%), Postives = 78/159 (49.06%), Query Frame = 1 
Query: 2311 ITKIGNGSYGEVYQCKEANFDGQFV-IKRFFV-------PEESVREININEEIKYF------KLLSNYRGLMRYDREICVAFSLFEESLDKKIKSY---CQKSEENEKKILRVAYEILKELKELHKWEIIHRDIKHDPFLF*HQNYTKINN-GIHSVFR 2733
            + +IG G+YG VY+ K+   DG+FV +KR  +       P  ++REI + ++I  F      +LL  +   M   RE     +L  E +D+ + +Y   C +    E KI  + Y+IL  +  LH   I+HRDIK    L       KI + G+  V++
Sbjct:    8 VAEIGTGAYGTVYKAKDLLNDGKFVALKRVRIQNSEEGMPLSTIREIALLKQIDNFAHPNVVRLLDIFHIPMLTARE--THLNLVFEHVDQDLAAYLEYCPQPGLGEWKIKDLTYQILNGVDFLHTHRIVHRDIKPQNILVTKDGQVKIADFGLARVYK 164
[Close]
BLAST of Cyclin-dependent kinase-like 1 vs. Ensembl Nematostella
Match: EDO38135 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7SDU1])

HSP 1 Score: 50.0618 bits (118), Expect = 3.507e-6
Identity = 38/132 (28.79%), Postives = 61/132 (46.21%), Query Frame = 1 
Query: 2320 IGNGSYGEVYQCKEANFDGQFVIKRFFVPEESVREININEEIKYFKLLSNYRGLMRYDR-----------EICVAFSLFEESLDKKIKSYCQKSEENEKKILRVAYEILKELKELHKWEIIHRDIKHDPFLF 2682
            +G GS+ +VY+C E      F +K F    E   E  +  EIK +K L + R +  Y             +     +L E+ L ++     + SE+    +LR   +IL+ L+ LH  +I+HRD+K D  L 
Sbjct:   17 LGEGSFAKVYKCIERKTQAPFALKEFDTKNEEYDEGTVQTEIKIWKDLQHERIVRLYASFRTGKYLYFVMDFLAGGNLLEDMLGRQ-----KYSEKEAASLLR---QILEALQYLHSRKIVHRDVKPDNILL 140
[Close]
BLAST of Cyclin-dependent kinase-like 1 vs. Ensembl Nematostella
Match: EDO35402 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7SLJ0])

HSP 1 Score: 49.6766 bits (117), Expect = 5.593e-6
Identity = 32/145 (22.07%), Postives = 75/145 (51.72%), Query Frame = 1 
Query: 2293 LKKEQMITKIGNGSYGEVYQCKEANFDGQFVIKRFFVPEE-------SVREININEEIKYFKLLSNYRGLMRYDREICVAFSLFEESLDKKIKSYCQKSEENEKKILRVAYEILKELKELHKWEIIHRDIKHDPFLF*HQNYTKI 2706
            ++K + +  +G GSYG V +C+  + +    IK+F   E+       ++RE+ +  ++++  L+ N   + R  + + + F   + ++   ++ Y    +EN   + +V +++L+ ++ +H+  IIHRD+K +  L       K+
Sbjct:    1 MEKYENLGLVGEGSYGMVMKCRHKDSNQIVAIKKFIESEDDKMVKKIAMREVRMLRQLRHENLV-NLIEVFRRKKRLFLVFEFVDHTVLDDLERYPNGLDEN--TVRKVMWQVLRAIEFIHRHNIIHRDVKPENILVSRSGIVKL 142
[Close]
BLAST of Cyclin-dependent kinase-like 1 vs. Ensembl Medaka
Match: cdk6 (cyclin dependent kinase 6 [Source:NCBI gene;Acc:101168879])

HSP 1 Score: 54.299 bits (129), Expect = 3.811e-7
Identity = 37/134 (27.61%), Postives = 72/134 (53.73%), Query Frame = 1 
Query: 2311 ITKIGNGSYGEVYQCKEANFDGQFV-IKRFFV-------PEESVREININEEIKYFKLLSNYR-----GLMRYDREICVAFSLFEESLDKKIKSYCQKSEE---NEKKILRVAYEILKELKELHKWEIIHRDIK 2664
            + +IG G+YG+VY+ ++   +G+FV +KR  V       P  ++RE+ +  +++ F+  +  R      + R DRE     +L  E +D+ + +Y +K  +     + I  + Y++L+ L  LH   ++HRD+K
Sbjct:   13 VAEIGEGAYGKVYKARDLKNEGRFVALKRVRVQTEEEGMPLSTIREVAVLRQLEAFEHPNVVRLFDVCTVSRTDRE--TKLTLVFEHVDQDLTTYLEKVPDPGVPPETIKDMMYQLLQGLDFLHSHRVVHRDLK 144
[Close]
BLAST of Cyclin-dependent kinase-like 1 vs. Ensembl Medaka
Match: ENSORLT00000001547.2 (cyclin-dependent kinase-like 1 [Source:NCBI gene;Acc:101157382])

HSP 1 Score: 53.5286 bits (127), Expect = 7.629e-7
Identity = 37/140 (26.43%), Postives = 72/140 (51.43%), Query Frame = 1 
Query: 2284 MKRLKKEQMITKIGNGSYGEVYQCKEANFDGQFVIKRFFVPEE-------SVREININEEIKYFKLLSNYRGLMRYDREICVAFSLFEESLDKKIKSYCQKSEENEKKILRVAYEILKELKELHKWEIIHRDIKHDPFLF 2682
            M  ++K + + KIG GSYG V++C+  +      IK+F   EE       ++REI + +++K+  L+ N   + R  R + + F   E+++  ++  + +   E + K   + ++ L+ +   HK   IHRD+K +  L 
Sbjct:    1 MDMMEKYEKLAKIGEGSYGVVFKCRNRDTGQIVAIKKFVESEEDPVIKKIALREIRMLKQLKHVNLV-NLLEVFRRKRRLHLVFEFCEQTVLNELDRHPRGVPEAQLK--SIVWQTLQAVNFCHKHNCIHRDVKPENILL 137
[Close]
BLAST of Cyclin-dependent kinase-like 1 vs. Ensembl Medaka
Match: cdkl1 (cyclin dependent kinase like 1 [Source:NCBI gene;Acc:101159782])

HSP 1 Score: 53.5286 bits (127), Expect = 9.652e-7
Identity = 40/155 (25.81%), Postives = 78/155 (50.32%), Query Frame = 1 
Query: 2263 MTIHFEEMKRLKKEQMITKIGNGSYGEVYQCKEANFDGQFVIKRFFVPEE-------SVREININEEIKYFKLLSNYRGLMRYDREICVAFSLFEESLDKKIKSYCQKSEENEKKILRVAYEILKELKELHKWEIIHRDIKHDPFLF*HQNYTKI 2706
            +T    E K+++K + I KIG GSYG V++C+         IK+F   +E       ++REI + +++K+  L+ N   + R  R++ + F   + ++  ++  + +   E+  K   + ++ L+ +   HK   IHRD+K +  L   Q   K+
Sbjct:   49 ITADLLEQKKMEKYEKIAKIGEGSYGVVFKCRSRETGQIVAIKKFVESDEDPIIRKIALREIRMLKQLKHANLV-NLMEVFRRKRKLHLVFEYCDHTVLNELDRHPRGVPEHLVK--SITWQTLQAVNFCHKQNCIHRDVKPENILITKQQVIKL 200
[Close]
BLAST of Cyclin-dependent kinase-like 1 vs. Ensembl Medaka
Match: cdkl1 (cyclin dependent kinase like 1 [Source:NCBI gene;Acc:101159782])

HSP 1 Score: 53.1434 bits (126), Expect = 1.193e-6
Identity = 40/155 (25.81%), Postives = 78/155 (50.32%), Query Frame = 1 
Query: 2263 MTIHFEEMKRLKKEQMITKIGNGSYGEVYQCKEANFDGQFVIKRFFVPEE-------SVREININEEIKYFKLLSNYRGLMRYDREICVAFSLFEESLDKKIKSYCQKSEENEKKILRVAYEILKELKELHKWEIIHRDIKHDPFLF*HQNYTKI 2706
            +T    E K+++K + I KIG GSYG V++C+         IK+F   +E       ++REI + +++K+  L+ N   + R  R++ + F   + ++  ++  + +   E+  K   + ++ L+ +   HK   IHRD+K +  L   Q   K+
Sbjct:   49 ITADLLEQKKMEKYEKIAKIGEGSYGVVFKCRSRETGQIVAIKKFVESDEDPIIRKIALREIRMLKQLKHANLV-NLMEVFRRKRKLHLVFEYCDHTVLNELDRHPRGVPEHLVK--SITWQTLQAVNFCHKQNCIHRDVKPENILITKQQVIKL 200
[Close]
BLAST of Cyclin-dependent kinase-like 1 vs. Planmine SMEST
Match: SMESG000078505.1 (SMESG000078505.1)

HSP 1 Score: 516.153 bits (1328), Expect = 1.320e-168
Identity = 262/271 (96.68%), Postives = 264/271 (97.42%), Query Frame = 1 
Query: 1870 VLHKECNLNPPFHKCWPKTDSFDAILIQAXXXXXXXNSGKSIMKKFVKHVSMGEMTREIMEDKIDKYFLQYGVLKVKMIKSTENLRIPLEEIRFFQLKKIAQITCGIEKDLLYFVNYDKRDLNIPIRITEHMTIHFEEMKRLKKEQMITKIGNGSYGEVYQCKEANFDGQFVIKRFFVPEESVREININEEIKYFKLLSNYRGLMRYDREICVAFSLFEESLDKKIKSYCQKSEENEKKILRVAYEILKELKELHKWEIIHRDIKHDPFLF 2682
            VLHKECNLNPPFHKCWPKTDSFDAILIQALKLLLKKNSGKSIMKKFVKHVSMGEMTREIMEDKIDKYFLQYGVLKVKMIKSTENLRIPLEEI FFQLKKIAQITCGIEKDLLYFVNYD+RDLNIPIRITEHMTIHFEEMKRLKKEQMI KIGNGSYGEVYQCKEANFDGQFVIKRF VPEESVREININEEIKYFKLLSNYRGLMRYDREICVAFSLFEESLDKKIKSYCQKSEENEKKILRVAYEILKELKELHKWEIIHRDIK +  L 
Sbjct:  217 VLHKECNLNPPFHKCWPKTDSFDAILIQALKLLLKKNSGKSIMKKFVKHVSMGEMTREIMEDKIDKYFLQYGVLKVKMIKSTENLRIPLEEISFFQLKKIAQITCGIEKDLLYFVNYDERDLNIPIRITEHMTIHFEEMKRLKKEQMIRKIGNGSYGEVYQCKEANFDGQFVIKRFIVPEESVREININEEIKYFKLLSNYRGLMRYDREICVAFSLFEESLDKKIKSYCQKSEENEKKILRVAYEILKELKELHKWEIIHRDIKPENILL 487
[Close]
BLAST of Cyclin-dependent kinase-like 1 vs. Planmine SMEST
Match: SMESG000078505.1 (SMESG000078505.1)

HSP 1 Score: 515.768 bits (1327), Expect = 9.824e-168
Identity = 262/271 (96.68%), Postives = 264/271 (97.42%), Query Frame = 1 
Query: 1870 VLHKECNLNPPFHKCWPKTDSFDAILIQAXXXXXXXNSGKSIMKKFVKHVSMGEMTREIMEDKIDKYFLQYGVLKVKMIKSTENLRIPLEEIRFFQLKKIAQITCGIEKDLLYFVNYDKRDLNIPIRITEHMTIHFEEMKRLKKEQMITKIGNGSYGEVYQCKEANFDGQFVIKRFFVPEESVREININEEIKYFKLLSNYRGLMRYDREICVAFSLFEESLDKKIKSYCQKSEENEKKILRVAYEILKELKELHKWEIIHRDIKHDPFLF 2682
            VLHKECNLNPPFHKCWPKTDSFDAILIQALKLLLKKNSGKSIMKKFVKHVSMGEMTREIMEDKIDKYFLQYGVLKVKMIKSTENLRIPLEEI FFQLKKIAQITCGIEKDLLYFVNYD+RDLNIPIRITEHMTIHFEEMKRLKKEQMI KIGNGSYGEVYQCKEANFDGQFVIKRF VPEESVREININEEIKYFKLLSNYRGLMRYDREICVAFSLFEESLDKKIKSYCQKSEENEKKILRVAYEILKELKELHKWEIIHRDIK +  L 
Sbjct:  266 VLHKECNLNPPFHKCWPKTDSFDAILIQALKLLLKKNSGKSIMKKFVKHVSMGEMTREIMEDKIDKYFLQYGVLKVKMIKSTENLRIPLEEISFFQLKKIAQITCGIEKDLLYFVNYDERDLNIPIRITEHMTIHFEEMKRLKKEQMIRKIGNGSYGEVYQCKEANFDGQFVIKRFIVPEESVREININEEIKYFKLLSNYRGLMRYDREICVAFSLFEESLDKKIKSYCQKSEENEKKILRVAYEILKELKELHKWEIIHRDIKPENILL 536
[Close]
BLAST of Cyclin-dependent kinase-like 1 vs. Planmine SMEST
Match: SMESG000078507.1 (SMESG000078507.1)

HSP 1 Score: 261.151 bits (666), Expect = 4.848e-74
Identity = 142/265 (53.58%), Postives = 192/265 (72.45%), Query Frame = 1 
Query: 1909 KCWPKTDSFDAILIQAXXXXXXXNSGKSI-MKKFVKHVSMGEMTREIMEDKIDKYFLQYGVLKVKMIKSTENLRIPLEEIRFFQLKKIAQITCGIEKDLLYFVNYDKRDLNIPIRITEHMTIHFEEMKRLKKEQMITKIGNGSYGEVYQCKEANFDGQFVIKRFFVPEESVREININEEIKYFKLLSNYRGLMRYDREICVAFSLFEESLDKKIKSYCQKSEE------NEKKILRVAYEILKELKELHKWEIIHRDIKHDPFLF 2682
            + W    S + I+I+ L+LLL+ + G    ++KF+KHV +GE++ E +E++I+ YF  YG LK+KM KSTE +++PL E+  F++ KIAQI CGI++DL+YFVNYD++DL  PI+I+ +MTIH EEM RLKKEQ   KIG GSYG+VY  KEAN D +F IK F    +SVREININEEIKY +L   YRGLM Y+++IC AFSLFE+SLD KIK   + +        +E +I+++AYEILKELK LHKW+I+H DIK +  L 
Sbjct:  288 RSWWDVSSMNDIIIKGLELLLQNDQGGEFFIQKFIKHVCVGEISGEYLENEIENYFHYYGNLKIKMTKSTEFIKVPLGEMSLFEINKIAQIFCGIDEDLIYFVNYDEQDLKDPIKISANMTIHLEEMTRLKKEQKRDKIGEGSYGKVYLFKEANSDDKFAIKIFNDSAKSVREININEEIKYLELFPKYRGLMSYNKKICAAFSLFEKSLDNKIKITIRSNPNFRVPLISENEIIKLAYEILKELKVLHKWKILHLDIKPENILL 552
[Close]
BLAST of Cyclin-dependent kinase-like 1 vs. Planmine SMEST
Match: SMESG000024746.1 (SMESG000024746.1)

HSP 1 Score: 75.485 bits (184), Expect = 2.190e-13
Identity = 60/195 (30.77%), Postives = 101/195 (51.79%), Query Frame = 1 
Query: 2155 QLKKIAQITCGIEKDLLYFV---------NYDKRDLNIPIRITEHMTIHFEEMKRLKKEQMITKIGNGSYGEVYQCKEANFDGQFVIKRFFVPEESVR-EININEEIKYFKLLSNYRGLMRYDREICVAFSLFEE-SLDKKIKSYCQKSEENEKKILRVAYEILKELKELHKWEIIHRDIKHDPFLF*HQNYTKI 2706
            ++KKI    CG E++ LY +         N D  D+ +P+         FE M++++  +++T +G GS+G V    +  F+ Q VIK+       +R +I IN        L  Y G ++    I +     +  SL  +I+  C++ +E  K+I+ +AY+ILK++KELH+  I+HRDIK D  +F  +   KI
Sbjct:  372 EVKKIIANRCGTEEEDLYCMYNHNDKKPKNEDPFDMKLPV--------FFELMRKMESFELVTVLGKGSFGTVKLYNDKIFEQQVVIKKQNDKNCDLRRDIFINSIKGGLGNLVKYLGTVKEGDSIHLVMEYLQGGSLTSRIRKICKQGKE--KEIIDIAYQILKQIKELHQLGIVHRDIKPDNIVFDGKGSPKI 556
[Close]
BLAST of Cyclin-dependent kinase-like 1 vs. Planmine SMEST
Match: SMESG000073002.1 (SMESG000073002.1)

HSP 1 Score: 72.7886 bits (177), Expect = 3.281e-13
Identity = 53/189 (28.04%), Postives = 91/189 (48.15%), Query Frame = 1 
Query: 2122 LRIPLEEIRFFQLKKIAQITCGIEKDLLYFVNYDKRDLNIPIRITEHMTIHFEEMKRLKKEQMITKIGNGSYGEVYQCKEANFDGQFVIKRFFVPEESV-REININEEIKYFKLLSNYRGLMRYDREICVAFSLFEESLDKKIKSYCQKSE-ENEKKILRVAYEILKELKELHKWEIIHRDIKHDPFLF 2682
            L IP       + K++    CG+  D  Y ++    D        E+  + FE M+ ++   +  ++ +G +G ++ C+       F+IK+     E++ REI IN +  Y   L    GL+R +   C+A   F       + SY ++    +EK+I  + Y+IL ++ ELH+  IIHRDIK D  +F
Sbjct:   11 LAIPSTPQTVIEAKRVIACKCGVSIDDFYCIDLYNSDKPNDWDTYEY-ELMFERMRNIENINITRELASGGFGRIFICQNKFSTNNFLIKKSINETENLHREIFINLQFFYSDKLFKISGLIRNENHPCLAMPYFPGG---SLASYIEQIRCLDEKEIGNILYQILMQINELHRLGIIHRDIKPDNIVF 195
The following BLAST results are available for this feature:
BLAST of Cyclin-dependent kinase-like 1 vs. Ensembl Human
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Human e!99)
Total hits: 3
Match NameE-valueIdentityDescription
CDKL36.165e-1032.62cyclin dependent kinase like 3 [Source:HGNC Symbol... [more]
CDKL31.269e-932.62cyclin dependent kinase like 3 [Source:HGNC Symbol... [more]
CDKL31.363e-932.62cyclin dependent kinase like 3 [Source:HGNC Symbol... [more]
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BLAST of Cyclin-dependent kinase-like 1 vs. Ensembl Celegans
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99)
Total hits: 3
Match NameE-valueIdentityDescription
cdkl-12.862e-626.06Cyclin-dependent kinase-like 1 [Source:UniProtKB/... [more]
cdkl-12.966e-626.06Cyclin-dependent kinase-like 1 [Source:UniProtKB/... [more]
cdkl-13.463e-626.95Cyclin-dependent kinase-like 1 [Source:UniProtKB/... [more]
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BLAST of Cyclin-dependent kinase-like 1 vs. Ensembl Fly
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99)
Total hits: 5
Match NameE-valueIdentityDescription
CG72363.942e-723.60gene:FBgn0031730 transcript:FBtr0302950[more]
CG72367.661e-725.34gene:FBgn0031730 transcript:FBtr0343388[more]
CG72368.922e-725.34gene:FBgn0031730 transcript:FBtr0343389[more]
CG72361.093e-625.34gene:FBgn0031730 transcript:FBtr0343387[more]
Ask15.789e-629.07gene:FBgn0014006 transcript:FBtr0300256[more]
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BLAST of Cyclin-dependent kinase-like 1 vs. Ensembl Zebrafish
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99)
Total hits: 3
Match NameE-valueIdentityDescription
cdk212.784e-726.79cyclin-dependent kinase 21 [Source:ZFIN;Acc:ZDB-GE... [more]
cdk63.038e-727.61cyclin-dependent kinase 6 [Source:ZFIN;Acc:ZDB-GEN... [more]
cdk63.298e-727.61cyclin-dependent kinase 6 [Source:ZFIN;Acc:ZDB-GEN... [more]
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BLAST of Cyclin-dependent kinase-like 1 vs. Ensembl Xenopus
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99)
Total hits: 0
Match NameE-valueIdentityDescription
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BLAST of Cyclin-dependent kinase-like 1 vs. Ensembl Mouse
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99)
Total hits: 5
Match NameE-valueIdentityDescription
Cdkl38.757e-1031.43cyclin-dependent kinase-like 3 [Source:MGI Symbol;... [more]
Cdkl33.811e-931.43cyclin-dependent kinase-like 3 [Source:MGI Symbol;... [more]
Cdkl33.811e-931.43cyclin-dependent kinase-like 3 [Source:MGI Symbol;... [more]
Cdkl34.683e-931.43cyclin-dependent kinase-like 3 [Source:MGI Symbol;... [more]
Cdkl37.667e-931.43cyclin-dependent kinase-like 3 [Source:MGI Symbol;... [more]
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BLAST of Cyclin-dependent kinase-like 1 vs. UniProt/SwissProt
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt)
Total hits: 5
Match NameE-valueIdentityDescription
sp|Q4R8T9|CDKL3_MACFA5.690e-932.62Cyclin-dependent kinase-like 3 OS=Macaca fascicula... [more]
sp|Q8IVW4|CDKL3_HUMAN6.545e-932.62Cyclin-dependent kinase-like 3 OS=Homo sapiens OX=... [more]
sp|Q9JM01|CDKL3_RAT5.780e-831.43Cyclin-dependent kinase-like 3 OS=Rattus norvegicu... [more]
sp|Q8BLF2|CDKL3_MOUSE6.759e-831.43Cyclin-dependent kinase-like 3 OS=Mus musculus OX=... [more]
sp|P34112|CDK1_DICDI9.407e-627.40Cyclin-dependent kinase 1 OS=Dictyostelium discoid... [more]
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BLAST of Cyclin-dependent kinase-like 1 vs. TrEMBL
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL)
Total hits: 5
Match NameE-valueIdentityDescription
A0A2B4R8T76.126e-3241.22Zinc finger MYM-type protein 1 OS=Stylophora pisti... [more]
A0A2B4R8291.185e-2834.36Zinc finger MYM-type protein 1 OS=Stylophora pisti... [more]
A0A2B4RLJ72.309e-2539.01Zinc finger MYM-type protein 1 OS=Stylophora pisti... [more]
A0A3M6TPX82.621e-2443.84Dimer_Tnp_hAT domain-containing protein OS=Pocillo... [more]
A0A2B4S5U58.709e-2439.22MICOS complex subunit MIC60 OS=Stylophora pistilla... [more]
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BLAST of Cyclin-dependent kinase-like 1 vs. Ensembl Cavefish
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99)
Total hits: 4
Match NameE-valueIdentityDescription
cdk62.047e-726.43cyclin dependent kinase 6 [Source:NCBI gene;Acc:10... [more]
cdk47.024e-624.84cyclin dependent kinase 4 [Source:NCBI gene;Acc:10... [more]
ENSAMXT00000057054.19.942e-625.55cyclin-dependent kinase-like 1 [Source:NCBI gene;A... [more]
ENSAMXT00000052448.19.942e-625.55cyclin-dependent kinase-like 1 [Source:NCBI gene;A... [more]
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BLAST of Cyclin-dependent kinase-like 1 vs. Ensembl Sea Lamprey
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99)
Total hits: 1
Match NameE-valueIdentityDescription
cdk47.423e-728.37cyclin-dependent kinase 4 [Source:ZFIN;Acc:ZDB-GEN... [more]
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BLAST of Cyclin-dependent kinase-like 1 vs. Ensembl Yeast
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46)
Total hits: 0
Match NameE-valueIdentityDescription
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BLAST of Cyclin-dependent kinase-like 1 vs. Ensembl Nematostella
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46)
Total hits: 3
Match NameE-valueIdentityDescription
EDO375674.233e-930.82Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7... [more]
EDO381353.507e-628.79Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7... [more]
EDO354025.593e-622.07Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7... [more]
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BLAST of Cyclin-dependent kinase-like 1 vs. Ensembl Medaka
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99)
Total hits: 4
Match NameE-valueIdentityDescription
cdk63.811e-727.61cyclin dependent kinase 6 [Source:NCBI gene;Acc:10... [more]
ENSORLT00000001547.27.629e-726.43cyclin-dependent kinase-like 1 [Source:NCBI gene;A... [more]
cdkl19.652e-725.81cyclin dependent kinase like 1 [Source:NCBI gene;A... [more]
cdkl11.193e-625.81cyclin dependent kinase like 1 [Source:NCBI gene;A... [more]
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BLAST of Cyclin-dependent kinase-like 1 vs. Planmine SMEST
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST)
Total hits: 5
Match NameE-valueIdentityDescription
SMESG000078505.11.320e-16896.68SMESG000078505.1[more]
SMESG000078505.19.824e-16896.68SMESG000078505.1[more]
SMESG000078507.14.848e-7453.58SMESG000078507.1[more]
SMESG000024746.12.190e-1330.77SMESG000024746.1[more]
SMESG000073002.13.281e-1328.04SMESG000073002.1[more]
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Sequences
The following sequences are available for this feature:

transcript sequence

>SMED30010718 ID=SMED30010718|Name=Cyclin-dependent kinase-like 1|organism=Schmidtea mediterranea sexual|type=transcript|length=3939bp
GTCGCACAGAACAAGTGGCAGTTTTTCTGAAGTACGTTTTGGATGGCAAA
ACAGTGGAGTCTTTCGTTGGTGTCTTCGAAACAACATCGACTGAGGGAGA
TGTGCTATATGCACTAGTGAAGGATATCATCACCTCACTTTGCCTTCGGG
ATCAGGATATCGTTGAAGAATGTTTTGATGGTAGGCACACATGTCAGTCA
TACATACAAGTCTTGCAGCAAGAATGAAAGAATCTTCTCCGCGATGAATA
TATGTCTACTCATATGCCCACCGTCTCAACTTATCACTCCTTTCTGCTTT
GGAAAAAGTAGATCCCTTTTGAAGTATGAAGGGAATACTCCAAAGTCTTC
ACAACTTCCTAGCTGCAAGTCCTAAATATCTGGCTGTATTTAAAAATGCG
CGAGTGGATAGTAACCGCATTTCTCTAACAATTAAATCCATCATCAGCGC
AACTAGATGGTCATGCGATTGGGAAGCGGTAAGATCTCTCACTGAACAAT
TTTCCAGTCTTTGTAAAGCACTTCTCGTCTTGGCGGACAGCAAAGATTTC
GACACATACACTGGAAGTCATGGACCTTTGATTAACATGTGCAAATTTGG
TTTTGCGTTGGGTTTACTTGTTCTGAAATGATGCTATCAAACATAAGTGC
CCATCACTACTAGAAGGAACACGGAACTAAACATTGTAACACTTCTTTTA
ATTCGCAATAAGGAAATGATCAAGACATTCTTTGCACATTAGAATATGTA
GTTTTAATGAATACCTATCACAAATAAAACTTGAGCGTGTATCAACGTTA
CACTGAATCAATGGAGAACTTCTACCAGCGTAGAAAAACATCAACACTGC
ATTTGTGGCTGGGCAGTCATTGTCAAATGGCAGGTCTACAACGGTAGATA
TAGTAAACGACATGCTTCTACAAGGACTACACGAAATATTACACATTTTC
TACAAACTGTCGTCGACCTTTGATGCAATTCCAGCAACATCCTGTTCTGT
AGAGAGGGATTTCAGTGGGCTTAGACGAATTTAAGCATACTTCTGCTCAA
AAATGTGACAAGATTGCTTGAAAAGTATTGCACTCATCAACATTGAACAG
GGATACGCGATTTGTTTATTGCAGGAAGTTATGGAGACCATCATCGACAT
ATTTGGAAGGCTGTAAAATCGCAATTCTTACTTTTTTAAACTTGATTTCA
GCCATTTATTTGCTTCTTCATATAATTCAGTATCGCTTCGTGCTGATCCT
TTGCATTGTACTTATGCACAGTCAAATTTAAACGTTTTCGTTAAAAATTC
GTTCATGACATCCATGAAATGAGAGTGCACATACGCCTATGACTCCTGCC
ATAAACATGCCAAGCTCAGCACCATTTTGTTCCATATTCTCATGTAGCGT
AGAGAAGGACATAGTGTTGGTTTCAAATACTGGTTATTTTTGTGTAATTC
CATTAAATAATTTGATTATATATATATATATTGCAAGGATTGTAAGAACG
AGGTCTAAATAATTTGTGAACTTTGTTTTAATAATATTGTTTCAAATTAT
TTTTTAAATAATTTATCACGTGGGACAAGTAAATTATAATATATTTAAAG
TCTCAGTTTATATGGCATCATCATTATATAGTTTTTCACCATAATTTTAT
TAACTGGTCCAATGATATTATTGTATTTGCAAACATTGATTTTGAGCGTA
TTTTTTAACCAATAGAATTCAGTTTATGAACGACAACCGGATAAATGACT
AATTAGAGTTAACATTATCAAAATCCAGAAATTATTTATCATAACCGAAA
AACTTGAGAATATACAGAAACTTTAAATAAATCAAAATTTTTATTTAAAA
TTAAAATTTTAGATTCATTGTGCTACACAAGGAATGCAATTTGAATCCTC
CCTTTCACAAATGTTGGCCTAAAACTGATTCGTTTGATGCCATTTTAATT
CAAGCTCTCAAACTTTTGCTTAAAAAGAACAGTGGAAAATCAATCATGAA
AAAATTTGTAAAACATGTTAGCATGGGAGAAATGACAAGAGAAATCATGG
AAGACAAAATTGACAAATATTTTTTACAATACGGAGTACTCAAAGTAAAA
ATGATAAAGTCAACGGAGAATCTACGAATCCCACTCGAAGAAATAAGATT
TTTTCAACTGAAGAAAATTGCACAAATTACTTGTGGGATTGAGAAAGATT
TGCTATATTTTGTTAATTATGACAAGCGAGATTTGAATATTCCAATCAGA
ATAACAGAACACATGACAATCCATTTTGAAGAAATGAAAAGATTAAAAAA
AGAACAAATGATTACAAAAATTGGAAATGGGTCTTATGGGGAAGTTTATC
AATGTAAAGAAGCTAATTTTGATGGTCAATTCGTAATCAAAAGATTTTTC
GTTCCTGAAGAAAGCGTTCGAGAAATTAATATAAATGAAGAAATAAAATA
TTTCAAATTGCTTTCAAACTATCGCGGGTTGATGAGGTATGACAGAGAGA
TCTGTGTCGCTTTCTCCCTATTTGAGGAATCGTTGGACAAAAAAATAAAA
TCTTATTGTCAAAAGTCTGAAGAAAATGAAAAAAAGATACTTAGGGTGGC
ATACGAAATCTTGAAAGAACTGAAAGAGCTCCACAAATGGGAAATTATTC
ATCGTGATATAAAGCATGACCCGTTCTTATTCTAACACCAAAACTACACA
AAGATCAATAATGGAATTCATTCAGTCTTTAGAATTATTTATACATGAAA
ACTATTTTGAAAAATATATTGAAGAAGTTGAAAAATTATTATTTAAACTA
ACGTAGACATCCGAAAAACTCAAATCAACGTTTGTGAAAAGGCTTCATTT
GATAAACCTGCAAATTTATCCTCAGATTTAAACGCTGATTTACCTTATTG
CAAAGGTATTGTTACATTCAGACAACATATTGCTACTAACCAAGGACAAC
AGTTGATACATTTATTGGTGAAAATTGTATAGAATATTAATTATGGAGAA
AAACTGCATAATTAGGAGATTTCCATTGAATTTACCTGCACTGAACAAAG
TAATAGAAAGGCCAATATTCTCAATCCCGAGTACTGATGAAACGACTCTT
GACTCAGGCGATTCAAACTATGAAGTCGAATTGGAGAAGGAATCGAAGAA
AAAACTAGCTTTTCAACAAAAATTAAACACAACCTTTCAGAAAGTGATGA
ATACAGTCGTGCAGTTCTTACATTTTCGTTTGCACCGAAATACAATTATA
AAAGAATTGAATTTATGGAAAATGCAACTATACAAAGCACTTTTGGTCAT
AGTTCAGCCGAACCAGTTTATGGAAAGAAATAAAAAAATAAAAAAAATAA
ATAATTAAAAATAGTAATTCTTAATATTTTGTAATGAAACTTTTAAATAT
TTTTAAAAATTAAAATTTACAAAATAATAATTAGAAAATTTATTAAAGTA
TAACAACAACGTAAAATTTAATAATATTTTCAAAATAATCAGCTTGGAAC
GCTAACAATATATCATTAAAAAATCTATATTATTTTTATTTTTAAATTGT
TTTAAAATTTAACGTAATTTTTTTATATAAAATAAAAATAAAAATAATTA
AATATATGATAAAAAACTTACTAAAGTTTGGTATTTGATAAAAGTGAATT
TTTTAAAAAATGCATTCAGTTATATATTAACAGACATAATATTCGTATTG
TTTTAATAACTATTGAAGCCATTATATAATCCAGAATCATATTGGAATTA
ATGAATTTCTATAAGATACTGGTTTTCAATAGTAATTATAGCTACTTTTT
CATCAAAAATGTCCATACGACGTTCGGTAGATGGGTGCAGATGGGCTTTG
TGGTTATATCGATATGTCAGCCATGGGCTCTGGTTGGGATTTAATCTTAA
TTATCTATATTATAAATACTAATAATTAATTAGATTAAT
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protein sequence of SMED30010718-orf-1

>SMED30010718-orf-1 ID=SMED30010718-orf-1|Name=SMED30010718-orf-1|organism=Schmidtea mediterranea sexual|type=polypeptide|length=102bp
MKGILQSLHNFLAASPKYLAVFKNARVDSNRISLTIKSIISATRWSCDWE
AVRSLTEQFSSLCKALLVLADSKDFDTYTGSHGPLINMCKFGFALGLLVL
K*
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protein sequence of SMED30010718-orf-2

>SMED30010718-orf-2 ID=SMED30010718-orf-2|Name=SMED30010718-orf-2|organism=Schmidtea mediterranea sexual|type=polypeptide|length=122bp
MEKNCIIRRFPLNLPALNKVIERPIFSIPSTDETTLDSGDSNYEVELEKE
SKKKLAFQQKLNTTFQKVMNTVVQFLHFRLHRNTIIKELNLWKMQLYKAL
LVIVQPNQFMERNKKIKKINN*
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protein sequence of SMED30010718-orf-3

>SMED30010718-orf-3 ID=SMED30010718-orf-3|Name=SMED30010718-orf-3|organism=Schmidtea mediterranea sexual|type=polypeptide|length=230bp
MKKFVKHVSMGEMTREIMEDKIDKYFLQYGVLKVKMIKSTENLRIPLEEI
RFFQLKKIAQITCGIEKDLLYFVNYDKRDLNIPIRITEHMTIHFEEMKRL
KKEQMITKIGNGSYGEVYQCKEANFDGQFVIKRFFVPEESVREININEEI
KYFKLLSNYRGLMRYDREICVAFSLFEESLDKKIKSYCQKSEENEKKILR
VAYEILKELKELHKWEIIHRDIKHDPFLF*
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Annotated Terms
The following terms have been associated with this transcript:
Vocabulary: Planarian Anatomy
TermDefinition
PLANA:0000026gut
PLANA:0000070intestinal phagocyte
PLANA:0000421tail
Vocabulary: INTERPRO
TermDefinition
IPR000719Prot_kinase_dom
IPR017441Protein_kinase_ATP_BS
IPR011009Kinase-like_dom_sf
Vocabulary: molecular function
TermDefinition
GO:0004672protein kinase activity
GO:0005524ATP binding
GO:0000166nucleotide binding
GO:0004674protein serine/threonine kinase activity
GO:0004693cyclin-dependent protein serine/threonine kinase activity
GO:0016301kinase activity
GO:0016740transferase activity
Vocabulary: biological process
TermDefinition
GO:0006468protein phosphorylation
GO:0016310phosphorylation
GO:0051726regulation of cell cycle
Vocabulary: cellular component
TermDefinition
GO:0005737cytoplasm