Signal peptidase complex subunit 2

Overview
NameSignal peptidase complex subunit 2
Smed IDSMED30010710
Length (bp)777
Neoblast Clusters

Zeng et. al., 2018



▻ Overview

▻ Neoblast Population

▻ Sub-lethal Irradiated Surviving X1 and X2 Cell Population

 

 

Overview

 

Single cell RNA-seq of pluripotent neoblasts and its early progenies


We isolated X1 neoblasts cells enriched in high piwi-1 expression (Neoblast Population), and profiled ∼7,614 individual cells via scRNA-seq. Unsupervised analyses uncovered 12 distinct classes from 7,088 high-quality cells. We designated these classes Nb1 to Nb12 and ordered them based on high (Nb1) to low (Nb12) piwi-1 expression levels. We further defined groups of genes that best classified the cells parsed into 12 distinct cell clusters to generate a scaled expression heat map of discriminative gene sets for each cluster. Expression of each cluster’s gene signatures was validated using multiplex fluorescence in situ hybridization (FISH) co-stained with piwi-1 and largely confirmed the cell clusters revealed by scRNA-seq.

We also tested sub-lethal irradiation exposure. To profile rare pluripotent stem cells (PSCs) and avoid interference from immediate progenitor cells, we determined a time point after sub-lethal irradiation (7 DPI) with minimal piwi-1+ cells, followed by isolation and single-cell RNA-seq of 1,200 individual cells derived from X1 (Piwi-1 high) and X2 (Piwi-1 low) cell populations (Sub-lethal Irradiated Surviving X1 and X2 Cell Population)



Explore this single cell expression dataset with our NB Cluster Shiny App



 

Neoblast Population

 

t-SNE plot shows two-dimensional representation of global gene expression relationships among all neoblasts (n = 7,088 after filter). Cluster identity was assigned based on the top 10 marker genes of each cluster (Table S2), followed by inspection of RNA in situ hybridization patterns. Neoblast groups, Nb.


Expression of Signal peptidase complex subunit 2 (SMED30010710) t-SNE clustered cells

Violin plots show distribution of expression levels for Signal peptidase complex subunit 2 (SMED30010710) in cells (dots) of each of the 12 neoblast clusters.

 

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Sub-lethal Irradiated Surviving X1 and X2 Cell Population

 

t-SNE plot of surviving X1 and X2 cells (n = 1,039 after QC filter) after sub-lethal irradiation. Colors indicate unbiased cell classification via graph-based clustering. SL, sub-lethal irradiated cell groups.

Expression of Signal peptidase complex subunit 2 (SMED30010710) in the t-SNE clustered sub-lethally irradiated X1 and X2 cells.

Violin plots show distribution of expression levels for Signal peptidase complex subunit 2 (SMED30010710) in cells (dots) of each of the 10 clusters of sub-leathally irradiated X1 and X2 cells.

 

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Embryonic Expression

Davies et. al., 2017

Hover the mouse over a column in the graph to view average RPKM values per sample.
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Embryonic Stages: Y: yolk. S2-S8: Stages 2-8. C4: asexual adult. SX: virgin, sexually mature adult.
For further information about sample preparation and analysis for the single animal RNA-Seq experiment, please refer to the Materials and Methods

 

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Anatomical Expression

PAGE et. al., 2020



SMED30010710

has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGE



PAGE Curations: 2

  
Expressed InReference TranscriptGene ModelsPublished TranscriptTranscriptomePublicationSpecimenLifecycleEvidence
epidermisSMED30010710SMESG000032194.1 dd_Smed_v4_1482_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018		FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
neoblastSMED30010710SMESG000032194.1 dd_Smed_v4_1482_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018		FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
Note: Hover over icons to view figure legend
Homology
[Close]
BLAST of Signal peptidase complex subunit 2 vs. Ensembl Human
Match: SPCS2 (signal peptidase complex subunit 2 [Source:HGNC Symbol;Acc:HGNC:28962])

HSP 1 Score: 159.073 bits (401), Expect = 1.295e-47
Identity = 79/177 (44.63%), Postives = 110/177 (62.15%), Query Frame = 1 
Query:   64 EKAIKVDKWDTNATKNALDDGFKKILKEQFKFEEKFSLIDGRLLISTISVLCGGVAVLFDWLYPFPASKLVLIICVLLYFILTGLLTCYIMFMERSTFFLAHEKDTAGIDKPIKWNFQSRMKKYQDKYELNVTREDLNTNQVAHMTEKRSIADFFDIKGNLRMDLLEKYVLTLKTNL 594
            +K +K+DKWD +A KN+LDD  KK+L E++K+ E F LIDGRL I TIS     VA+++D+++PFP SK VL +CV+ YF++ G+LT Y  + E+S F +AH KD  G+D    W   S +K++ DKY L +T     T Q       +SIA FFD  G L MD  E  +  L  +L
Sbjct:   43 DKPVKIDKWDGSAVKNSLDDSAKKVLLEKYKYVENFGLIDGRLTICTISCFFAIVALIWDYMHPFPESKPVLALCVISYFVMMGILTIYTSYKEKSIFLVAHRKDPTGMDPDDIWQLSSSLKRFDDKYTLKLTFISGRTKQQREAEFTKSIAKFFDHSGTLVMDAYEPEISRLHDSL 219
[Close]
BLAST of Signal peptidase complex subunit 2 vs. Ensembl Human
Match: SPCS2 (signal peptidase complex subunit 2 [Source:HGNC Symbol;Acc:HGNC:28962])

HSP 1 Score: 159.458 bits (402), Expect = 2.564e-47
Identity = 79/177 (44.63%), Postives = 110/177 (62.15%), Query Frame = 1 
Query:   64 EKAIKVDKWDTNATKNALDDGFKKILKEQFKFEEKFSLIDGRLLISTISVLCGGVAVLFDWLYPFPASKLVLIICVLLYFILTGLLTCYIMFMERSTFFLAHEKDTAGIDKPIKWNFQSRMKKYQDKYELNVTREDLNTNQVAHMTEKRSIADFFDIKGNLRMDLLEKYVLTLKTNL 594
            +K +K+DKWD +A KN+LDD  KK+L E++K+ E F LIDGRL I TIS     VA+++D+++PFP SK VL +CV+ YF++ G+LT Y  + E+S F +AH KD  G+D    W   S +K++ DKY L +T     T Q       +SIA FFD  G L MD  E  +  L  +L
Sbjct:   74 DKPVKIDKWDGSAVKNSLDDSAKKVLLEKYKYVENFGLIDGRLTICTISCFFAIVALIWDYMHPFPESKPVLALCVISYFVMMGILTIYTSYKEKSIFLVAHRKDPTGMDPDDIWQLSSSLKRFDDKYTLKLTFISGRTKQQREAEFTKSIAKFFDHSGTLVMDAYEPEISRLHDSL 250
[Close]
BLAST of Signal peptidase complex subunit 2 vs. Ensembl Human
Match: SPCS2 (signal peptidase complex subunit 2 [Source:HGNC Symbol;Acc:HGNC:28962])

HSP 1 Score: 154.451 bits (389), Expect = 8.658e-46
Identity = 79/178 (44.38%), Postives = 110/178 (61.80%), Query Frame = 1 
Query:   64 EKAIKVDKWDTNATKNALDDGFKKILKEQFKFEEKFSLIDGRLLISTISVLCGGVAVLFDWLYPFPASKLVLIICVL-LYFILTGLLTCYIMFMERSTFFLAHEKDTAGIDKPIKWNFQSRMKKYQDKYELNVTREDLNTNQVAHMTEKRSIADFFDIKGNLRMDLLEKYVLTLKTNL 594
            +K +K+DKWD +A KN+LDD  KK+L E++K+ E F LIDGRL I TIS     VA+++D+++PFP SK VL +CV+  YF++ G+LT Y  + E+S F +AH KD  G+D    W   S +K++ DKY L +T     T Q       +SIA FFD  G L MD  E  +  L  +L
Sbjct:   43 DKPVKIDKWDGSAVKNSLDDSAKKVLLEKYKYVENFGLIDGRLTICTISCFFAIVALIWDYMHPFPESKPVLALCVISSYFVMMGILTIYTSYKEKSIFLVAHRKDPTGMDPDDIWQLSSSLKRFDDKYTLKLTFISGRTKQQREAEFTKSIAKFFDHSGTLVMDAYEPEISRLHDSL 220
[Close]
BLAST of Signal peptidase complex subunit 2 vs. Ensembl Human
Match: SPCS2 (signal peptidase complex subunit 2 [Source:HGNC Symbol;Acc:HGNC:28962])

HSP 1 Score: 127.102 bits (318), Expect = 5.575e-36
Identity = 58/119 (48.74%), Postives = 82/119 (68.91%), Query Frame = 1 
Query:   64 EKAIKVDKWDTNATKNALDDGFKKILKEQFKFEEKFSLIDGRLLISTISVLCGGVAVLFDWLYPFPASKLVLIICVLLYFILTGLLTCYIMFMERSTFFLAHEKDTAGIDKPIKWNFQS 420
            +K +K+DKWD +A KN+LDD  KK+L E++K+ E F LIDGRL I TIS     VA+++D+++PFP SK VL +CV+ YF++ G+LT Y  + E+S F +AH KD  G+D    W   S
Sbjct:   47 DKPVKIDKWDGSAVKNSLDDSAKKVLLEKYKYVENFGLIDGRLTICTISCFFAIVALIWDYMHPFPESKPVLALCVISYFVMMGILTIYTSYKEKSIFLVAHRKDPTGMDPDDIWQLSS 165
[Close]
BLAST of Signal peptidase complex subunit 2 vs. Ensembl Human
Match: SPCS2 (signal peptidase complex subunit 2 [Source:HGNC Symbol;Acc:HGNC:28962])

HSP 1 Score: 56.225 bits (134), Expect = 3.086e-9
Identity = 32/84 (38.10%), Postives = 42/84 (50.00%), Query Frame = 1 
Query:  343 ERSTFFLAHEKDTAGIDKPIKWNFQSRMKKYQDKYELNVTREDLNTNQVAHMTEKRSIADFFDIKGNLRMDLLEKYVLTLKTNL 594
            E+S F +AH KD  G+D    W   S +K++ DKY L +T     T Q       +SIA FFD  G L MD  E  +  L  +L
Sbjct:   67 EKSIFLVAHRKDPTGMDPDDIWQLSSSLKRFDDKYTLKLTFISGRTKQQREAEFTKSIAKFFDHSGTLVMDAYEPEISRLHDSL 150
[Close]
BLAST of Signal peptidase complex subunit 2 vs. Ensembl Celegans
Match: spcs-2 (Probable signal peptidase complex subunit 2 [Source:UniProtKB/Swiss-Prot;Acc:Q9XWW1])

HSP 1 Score: 98.5969 bits (244), Expect = 2.773e-25
Identity = 62/180 (34.44%), Postives = 97/180 (53.89%), Query Frame = 1 
Query:   58 MPEKAIKV-DKWDTNATKNALDDGFKKILKEQFKFEEKFSLIDGRLLISTISVLCGGVAVLFDWLYPFPASKLVLIICVLLYFILTGLLTCYIMFMERSTFFLAHEKDTAGIDKPIKWNFQSRMKKYQDKYELNVTREDLNTNQVAHMTEKRSIADFFDIKGNLRMDLLEKYVLTLKTNL 594
            M ++ +KV +KWD    KNALD+  KKIL ++  + E  +L++ RLLIS I V     A  +D+  PFP SK+VL +C + YFI  G+L  Y  ++E+   + A E D     +  KW + S +K + DKY L+   +    +    +T  +SI  + D  G + + L++K V  L   L
Sbjct:    1 MTDEPVKVVNKWDGPTVKNALDEVVKKILNDKVGWTESHNLMNLRLLISFIGVAFSAFACGYDYYEPFPKSKIVLAVCSVSYFICMGILQMYQWYVEKDCIYEATEVDGK---QSRKWAWSSEIKAHDDKYTLSAEFKKEGRSGQGKIT--KSIGAYIDNDGEIIVPLVKKEVDDLYNRL 175
[Close]
BLAST of Signal peptidase complex subunit 2 vs. Ensembl Celegans
Match: spcs-2 (Probable signal peptidase complex subunit 2 [Source:UniProtKB/Swiss-Prot;Acc:Q9XWW1])

HSP 1 Score: 98.5969 bits (244), Expect = 2.773e-25
Identity = 62/180 (34.44%), Postives = 97/180 (53.89%), Query Frame = 1 
Query:   58 MPEKAIKV-DKWDTNATKNALDDGFKKILKEQFKFEEKFSLIDGRLLISTISVLCGGVAVLFDWLYPFPASKLVLIICVLLYFILTGLLTCYIMFMERSTFFLAHEKDTAGIDKPIKWNFQSRMKKYQDKYELNVTREDLNTNQVAHMTEKRSIADFFDIKGNLRMDLLEKYVLTLKTNL 594
            M ++ +KV +KWD    KNALD+  KKIL ++  + E  +L++ RLLIS I V     A  +D+  PFP SK+VL +C + YFI  G+L  Y  ++E+   + A E D     +  KW + S +K + DKY L+   +    +    +T  +SI  + D  G + + L++K V  L   L
Sbjct:    1 MTDEPVKVVNKWDGPTVKNALDEVVKKILNDKVGWTESHNLMNLRLLISFIGVAFSAFACGYDYYEPFPKSKIVLAVCSVSYFICMGILQMYQWYVEKDCIYEATEVDGK---QSRKWAWSSEIKAHDDKYTLSAEFKKEGRSGQGKIT--KSIGAYIDNDGEIIVPLVKKEVDDLYNRL 175
[Close]
BLAST of Signal peptidase complex subunit 2 vs. Ensembl Fly
Match: Spase25 (gene:FBgn0030306 transcript:FBtr0340293)

HSP 1 Score: 108.997 bits (271), Expect = 7.677e-29
Identity = 64/184 (34.78%), Postives = 103/184 (55.98%), Query Frame = 1 
Query:   64 EKAIKVDKWDTNATKNALDDGFKK-ILKEQFKFEEKFSLIDGRLLISTISVLCGGVAVLFDWLYPFPASKLVLIICVLLYFILTGLLTCYIMFMERSTFFLAHEKDTAGIDKPIKWNFQSRMKKYQDKYELNVTREDLNTNQVAHMTEKRSIADFFDIKGNLRMDLLEKYVLTLKTNLESKKTN 612
            E+ +KV+KWD +A K+ALDD  K  +L ++ + +E+F L++ RL +  ++V    +A  +D+ +PFP S+ VL+  VL YF L G+LT +  F E+ TF +A +KD    ++   W   S M+KY DKY L ++  D    +    +  +S A F D  G +  +L+   V  L   L + K N
Sbjct:   12 EELVKVNKWDGSAVKHALDDAVKTCLLGDRPQLKEQFGLVNTRLALCALAVSVAIMAHAWDFTHPFPESRPVLLFSVLAYFALLGILTLHSSFREKGTFAVALQKDK---ERERLWEASSDMRKYDDKYLLTLSVRDTKNGKRREQSSNKSCAAFIDQNGIVLDNLVANEVNRLFNALAADKKN 192
[Close]
BLAST of Signal peptidase complex subunit 2 vs. Ensembl Fly
Match: Spase25 (gene:FBgn0030306 transcript:FBtr0073506)

HSP 1 Score: 108.997 bits (271), Expect = 7.677e-29
Identity = 64/184 (34.78%), Postives = 103/184 (55.98%), Query Frame = 1 
Query:   64 EKAIKVDKWDTNATKNALDDGFKK-ILKEQFKFEEKFSLIDGRLLISTISVLCGGVAVLFDWLYPFPASKLVLIICVLLYFILTGLLTCYIMFMERSTFFLAHEKDTAGIDKPIKWNFQSRMKKYQDKYELNVTREDLNTNQVAHMTEKRSIADFFDIKGNLRMDLLEKYVLTLKTNLESKKTN 612
            E+ +KV+KWD +A K+ALDD  K  +L ++ + +E+F L++ RL +  ++V    +A  +D+ +PFP S+ VL+  VL YF L G+LT +  F E+ TF +A +KD    ++   W   S M+KY DKY L ++  D    +    +  +S A F D  G +  +L+   V  L   L + K N
Sbjct:   12 EELVKVNKWDGSAVKHALDDAVKTCLLGDRPQLKEQFGLVNTRLALCALAVSVAIMAHAWDFTHPFPESRPVLLFSVLAYFALLGILTLHSSFREKGTFAVALQKDK---ERERLWEASSDMRKYDDKYLLTLSVRDTKNGKRREQSSNKSCAAFIDQNGIVLDNLVANEVNRLFNALAADKKN 192
[Close]
BLAST of Signal peptidase complex subunit 2 vs. Ensembl Fly
Match: Spase25 (gene:FBgn0030306 transcript:FBtr0340294)

HSP 1 Score: 108.997 bits (271), Expect = 7.677e-29
Identity = 64/184 (34.78%), Postives = 103/184 (55.98%), Query Frame = 1 
Query:   64 EKAIKVDKWDTNATKNALDDGFKK-ILKEQFKFEEKFSLIDGRLLISTISVLCGGVAVLFDWLYPFPASKLVLIICVLLYFILTGLLTCYIMFMERSTFFLAHEKDTAGIDKPIKWNFQSRMKKYQDKYELNVTREDLNTNQVAHMTEKRSIADFFDIKGNLRMDLLEKYVLTLKTNLESKKTN 612
            E+ +KV+KWD +A K+ALDD  K  +L ++ + +E+F L++ RL +  ++V    +A  +D+ +PFP S+ VL+  VL YF L G+LT +  F E+ TF +A +KD    ++   W   S M+KY DKY L ++  D    +    +  +S A F D  G +  +L+   V  L   L + K N
Sbjct:   12 EELVKVNKWDGSAVKHALDDAVKTCLLGDRPQLKEQFGLVNTRLALCALAVSVAIMAHAWDFTHPFPESRPVLLFSVLAYFALLGILTLHSSFREKGTFAVALQKDK---ERERLWEASSDMRKYDDKYLLTLSVRDTKNGKRREQSSNKSCAAFIDQNGIVLDNLVANEVNRLFNALAADKKN 192
[Close]
BLAST of Signal peptidase complex subunit 2 vs. Ensembl Zebrafish
Match: spcs2 (signal peptidase complex subunit 2 [Source:NCBI gene;Acc:541342])

HSP 1 Score: 160.999 bits (406), Expect = 6.290e-49
Identity = 80/181 (44.20%), Postives = 115/181 (63.54%), Query Frame = 1 
Query:   64 EKAIKVDKWDTNATKNALDDGFKKILKEQFKFEEKFSLIDGRLLISTISVLCGGVAVLFDWLYPFPASKLVLIICVLLYFILTGLLTCYIMFMERSTFFLAHEKDTAGIDKPIKWNFQSRMKKYQDKYELNVTREDLNTNQVAHMTEKRSIADFFDIKGNLRMDLLEKYVLTLKTNLESKK 606
            EK +K+DKWD  A KN+LDD  KK+L E++ + E F+L+DGRL I T+S L   VA+++D+L+PFP SK VL  CV+ YFI+ G+LT Y  + E++ F +A +KD AG+D    W   S +K++ D+Y L ++  D  T Q       +S++ FFD  G L MD  EKYV  L   L ++K
Sbjct:   18 EKPVKIDKWDGAAVKNSLDDAAKKVLIEKYGYLESFNLVDGRLFICTVSCLFAIVALIWDYLHPFPESKPVLACCVVSYFIMMGILTLYTSYKEKNIFLVAMQKDPAGMDPDHNWCLSSSLKRFDDQYTLRMSFTDGKTKQSRETEFTKSVSVFFDENGTLVMDQYEKYVSKLHDTLATEK 198
[Close]
BLAST of Signal peptidase complex subunit 2 vs. Ensembl Zebrafish
Match: spcs2 (signal peptidase complex subunit 2 [Source:NCBI gene;Acc:541342])

HSP 1 Score: 159.458 bits (402), Expect = 3.050e-48
Identity = 79/181 (43.65%), Postives = 114/181 (62.98%), Query Frame = 1 
Query:   64 EKAIKVDKWDTNATKNALDDGFKKILKEQFKFEEKFSLIDGRLLISTISVLCGGVAVLFDWLYPFPASKLVLIICVLLYFILTGLLTCYIMFMERSTFFLAHEKDTAGIDKPIKWNFQSRMKKYQDKYELNVTREDLNTNQVAHMTEKRSIADFFDIKGNLRMDLLEKYVLTLKTNLESKK 606
            EK +K+DKWD  A KN+LDD  KK+L E++ + E F+L+DGRL I T+S L   VA+++D+L+PFP SK VL  C+  YFI+ G+LT Y  + E++ F +A +KD AG+D    W   S +K++ D+Y L ++  D  T Q       +S++ FFD  G L MD  EKYV  L   L ++K
Sbjct:   18 EKPVKIDKWDGAAVKNSLDDAAKKVLIEKYGYLESFNLVDGRLFICTVSCLFAIVALIWDYLHPFPESKPVLACCINTYFIMMGILTLYTSYKEKNIFLVAMQKDPAGMDPDHNWCLSSSLKRFDDQYTLRMSFTDGKTKQSRETEFTKSVSVFFDENGTLVMDQYEKYVSKLHDTLATEK 198
[Close]
BLAST of Signal peptidase complex subunit 2 vs. Ensembl Mouse
Match: Spcs2 (signal peptidase complex subunit 2 homolog (S. cerevisiae) [Source:MGI Symbol;Acc:MGI:1913874])

HSP 1 Score: 160.229 bits (404), Expect = 1.121e-48
Identity = 79/181 (43.65%), Postives = 113/181 (62.43%), Query Frame = 1 
Query:   64 EKAIKVDKWDTNATKNALDDGFKKILKEQFKFEEKFSLIDGRLLISTISVLCGGVAVLFDWLYPFPASKLVLIICVLLYFILTGLLTCYIMFMERSTFFLAHEKDTAGIDKPIKWNFQSRMKKYQDKYELNVTREDLNTNQVAHMTEKRSIADFFDIKGNLRMDLLEKYVLTLKTNLESKK 606
            +K +K+DKWD +A KN+LDD  KK+L E++K+ E F LIDGRL I TIS     VA+++D+++PFP SK VL +CV+ YF++ G+LT Y  + E+S F +AH KD  G+D    W   S +K++ DKY L +T     T Q       +SIA FFD  G L MD  E  +  L  +L +++
Sbjct:    7 DKPVKIDKWDGSAVKNSLDDSAKKVLLEKYKYVENFGLIDGRLTICTISCFFAIVALIWDYMHPFPESKPVLALCVISYFVMMGILTIYTSYKEKSIFLVAHRKDPTGMDPDDIWQLSSSLKRFDDKYTLKLTFISGRTKQQREAEFTKSIAKFFDHSGTLVMDAYEPEISRLHDSLATER 187
[Close]
BLAST of Signal peptidase complex subunit 2 vs. Ensembl Mouse
Match: Spcs2 (signal peptidase complex subunit 2 homolog (S. cerevisiae) [Source:MGI Symbol;Acc:MGI:1913874])

HSP 1 Score: 160.614 bits (405), Expect = 2.358e-48
Identity = 79/181 (43.65%), Postives = 113/181 (62.43%), Query Frame = 1 
Query:   64 EKAIKVDKWDTNATKNALDDGFKKILKEQFKFEEKFSLIDGRLLISTISVLCGGVAVLFDWLYPFPASKLVLIICVLLYFILTGLLTCYIMFMERSTFFLAHEKDTAGIDKPIKWNFQSRMKKYQDKYELNVTREDLNTNQVAHMTEKRSIADFFDIKGNLRMDLLEKYVLTLKTNLESKK 606
            +K +K+DKWD +A KN+LDD  KK+L E++K+ E F LIDGRL I TIS     VA+++D+++PFP SK VL +CV+ YF++ G+LT Y  + E+S F +AH KD  G+D    W   S +K++ DKY L +T     T Q       +SIA FFD  G L MD  E  +  L  +L +++
Sbjct:   43 DKPVKIDKWDGSAVKNSLDDSAKKVLLEKYKYVENFGLIDGRLTICTISCFFAIVALIWDYMHPFPESKPVLALCVISYFVMMGILTIYTSYKEKSIFLVAHRKDPTGMDPDDIWQLSSSLKRFDDKYTLKLTFISGRTKQQREAEFTKSIAKFFDHSGTLVMDAYEPEISRLHDSLATER 223
[Close]
BLAST of Signal peptidase complex subunit 2 vs. Ensembl Mouse
Match: Spcs2 (signal peptidase complex subunit 2 homolog (S. cerevisiae) [Source:MGI Symbol;Acc:MGI:1913874])

HSP 1 Score: 160.614 bits (405), Expect = 4.119e-48
Identity = 79/181 (43.65%), Postives = 113/181 (62.43%), Query Frame = 1 
Query:   64 EKAIKVDKWDTNATKNALDDGFKKILKEQFKFEEKFSLIDGRLLISTISVLCGGVAVLFDWLYPFPASKLVLIICVLLYFILTGLLTCYIMFMERSTFFLAHEKDTAGIDKPIKWNFQSRMKKYQDKYELNVTREDLNTNQVAHMTEKRSIADFFDIKGNLRMDLLEKYVLTLKTNLESKK 606
            +K +K+DKWD +A KN+LDD  KK+L E++K+ E F LIDGRL I TIS     VA+++D+++PFP SK VL +CV+ YF++ G+LT Y  + E+S F +AH KD  G+D    W   S +K++ DKY L +T     T Q       +SIA FFD  G L MD  E  +  L  +L +++
Sbjct:   69 DKPVKIDKWDGSAVKNSLDDSAKKVLLEKYKYVENFGLIDGRLTICTISCFFAIVALIWDYMHPFPESKPVLALCVISYFVMMGILTIYTSYKEKSIFLVAHRKDPTGMDPDDIWQLSSSLKRFDDKYTLKLTFISGRTKQQREAEFTKSIAKFFDHSGTLVMDAYEPEISRLHDSLATER 249
[Close]
BLAST of Signal peptidase complex subunit 2 vs. Ensembl Mouse
Match: Spcs2 (signal peptidase complex subunit 2 homolog (S. cerevisiae) [Source:MGI Symbol;Acc:MGI:1913874])

HSP 1 Score: 160.614 bits (405), Expect = 5.257e-48
Identity = 79/181 (43.65%), Postives = 113/181 (62.43%), Query Frame = 1 
Query:   64 EKAIKVDKWDTNATKNALDDGFKKILKEQFKFEEKFSLIDGRLLISTISVLCGGVAVLFDWLYPFPASKLVLIICVLLYFILTGLLTCYIMFMERSTFFLAHEKDTAGIDKPIKWNFQSRMKKYQDKYELNVTREDLNTNQVAHMTEKRSIADFFDIKGNLRMDLLEKYVLTLKTNLESKK 606
            +K +K+DKWD +A KN+LDD  KK+L E++K+ E F LIDGRL I TIS     VA+++D+++PFP SK VL +CV+ YF++ G+LT Y  + E+S F +AH KD  G+D    W   S +K++ DKY L +T     T Q       +SIA FFD  G L MD  E  +  L  +L +++
Sbjct:   77 DKPVKIDKWDGSAVKNSLDDSAKKVLLEKYKYVENFGLIDGRLTICTISCFFAIVALIWDYMHPFPESKPVLALCVISYFVMMGILTIYTSYKEKSIFLVAHRKDPTGMDPDDIWQLSSSLKRFDDKYTLKLTFISGRTKQQREAEFTKSIAKFFDHSGTLVMDAYEPEISRLHDSLATER 257
[Close]
BLAST of Signal peptidase complex subunit 2 vs. Ensembl Mouse
Match: Spcs2 (signal peptidase complex subunit 2 homolog (S. cerevisiae) [Source:MGI Symbol;Acc:MGI:1913874])

HSP 1 Score: 130.568 bits (327), Expect = 3.111e-37
Identity = 59/123 (47.97%), Postives = 85/123 (69.11%), Query Frame = 1 
Query:   64 EKAIKVDKWDTNATKNALDDGFKKILKEQFKFEEKFSLIDGRLLISTISVLCGGVAVLFDWLYPFPASKLVLIICVLLYFILTGLLTCYIMFMERSTFFLAHEKDTAGIDKPIKWNFQSRMKK 432
            +K +K+DKWD +A KN+LDD  KK+L E++K+ E F LIDGRL I TIS     VA+++D+++PFP SK VL +CV+ YF++ G+LT Y  + E+S F +AH KD  G+D    W   S +K+
Sbjct:   43 DKPVKIDKWDGSAVKNSLDDSAKKVLLEKYKYVENFGLIDGRLTICTISCFFAIVALIWDYMHPFPESKPVLALCVISYFVMMGILTIYTSYKEKSIFLVAHRKDPTGMDPDDIWQLSSSLKR 165
[Close]
BLAST of Signal peptidase complex subunit 2 vs. UniProt/SwissProt
Match: sp|Q5M8Y1|SPCS2_XENTR (Probable signal peptidase complex subunit 2 OS=Xenopus tropicalis OX=8364 GN=spcs2 PE=2 SV=1)

HSP 1 Score: 164.851 bits (416), Expect = 1.588e-49
Identity = 84/181 (46.41%), Postives = 116/181 (64.09%), Query Frame = 1 
Query:   64 EKAIKVDKWDTNATKNALDDGFKKILKEQFKFEEKFSLIDGRLLISTISVLCGGVAVLFDWLYPFPASKLVLIICVLLYFILTGLLTCYIMFMERSTFFLAHEKDTAGIDKPIKWNFQSRMKKYQDKYELNVTREDLNTNQVAHMTEKRSIADFFDIKGNLRMDLLEKYVLTLKTNLESKK 606
            +K +K+DKWD +A KN+LDD  KK+L E++++ E F LIDGRL+I TIS +   VA+++D+L+PFP SK VL ICV+ YF++ G+LT Y  + E+S F +AH KD AG+D    W+  S +K++ DKY L VT     T         +SIA FFD  G L MDL E  V  L  +L  +K
Sbjct:   18 DKPVKIDKWDGSAVKNSLDDAAKKVLLEKYRYVENFCLIDGRLIICTISCVFAIVALVWDYLHPFPESKPVLAICVISYFLMMGILTIYTSYKEKSIFLVAHRKDPAGMDPDDIWHLSSSLKRFDDKYTLKVTYISGKTKAQRDAEFTKSIARFFDDNGTLVMDLFEPEVSKLHDSLAMEK 198
[Close]
BLAST of Signal peptidase complex subunit 2 vs. UniProt/SwissProt
Match: sp|Q5BJI9|SPCS2_DANRE (Probable signal peptidase complex subunit 2 OS=Danio rerio OX=7955 GN=spcs2 PE=2 SV=1)

HSP 1 Score: 160.229 bits (404), Expect = 9.487e-48
Identity = 80/181 (44.20%), Postives = 115/181 (63.54%), Query Frame = 1 
Query:   64 EKAIKVDKWDTNATKNALDDGFKKILKEQFKFEEKFSLIDGRLLISTISVLCGGVAVLFDWLYPFPASKLVLIICVLLYFILTGLLTCYIMFMERSTFFLAHEKDTAGIDKPIKWNFQSRMKKYQDKYELNVTREDLNTNQVAHMTEKRSIADFFDIKGNLRMDLLEKYVLTLKTNLESKK 606
            EK +K+DKWD  A KN+LDD  KK+L E++ + E F+L+DGRL I T+S L   VA+++D+L+PFP SK VL  CV+ YFI+ G+LT Y  + E++ F +A +KD AG+D    W   S +K++ D+Y L ++  D  T Q       +S++ FFD  G L MD  EKYV  L   L ++K
Sbjct:   18 EKPVKIDKWDGAAVKNSLDDAAKKVLIEKYGYLESFNLVDGRLFICTVSCLFTIVALIWDYLHPFPESKPVLACCVVSYFIMMGILTLYTSYKEKNIFLVAMQKDPAGMDPDHSWCLSSSLKRFDDQYTLRMSFTDGKTKQSRETEFTKSVSVFFDENGTLVMDQYEKYVSKLHDTLATEK 198
[Close]
BLAST of Signal peptidase complex subunit 2 vs. UniProt/SwissProt
Match: sp|Q28250|SPCS2_CANLF (Signal peptidase complex subunit 2 OS=Canis lupus familiaris OX=9615 GN=SPCS2 PE=1 SV=1)

HSP 1 Score: 160.614 bits (405), Expect = 1.614e-47
Identity = 79/181 (43.65%), Postives = 113/181 (62.43%), Query Frame = 1 
Query:   64 EKAIKVDKWDTNATKNALDDGFKKILKEQFKFEEKFSLIDGRLLISTISVLCGGVAVLFDWLYPFPASKLVLIICVLLYFILTGLLTCYIMFMERSTFFLAHEKDTAGIDKPIKWNFQSRMKKYQDKYELNVTREDLNTNQVAHMTEKRSIADFFDIKGNLRMDLLEKYVLTLKTNLESKK 606
            +K +K+DKWD +A KN+LDD  KK+L E++K+ E F LIDGRL I TIS     VA+++D+++PFP SK VL +CV+ YF++ G+LT Y  + E+S F +AH KD  G+D    W   S +K++ DKY L +T     T Q       +SIA FFD  G L MD  E  +  L  +L +++
Sbjct:   43 DKPVKIDKWDGSAVKNSLDDSAKKVLLEKYKYVENFGLIDGRLTICTISCFFAIVALIWDYMHPFPESKPVLALCVISYFVMMGILTIYTSYKEKSIFLVAHRKDPTGMDPDDIWQLSSSLKRFDDKYTLKLTFISGRTKQQREAEFTKSIAKFFDHSGTLVMDAYEPEISRLHDSLATER 223
[Close]
BLAST of Signal peptidase complex subunit 2 vs. UniProt/SwissProt
Match: sp|Q9CYN2|SPCS2_MOUSE (Signal peptidase complex subunit 2 OS=Mus musculus OX=10090 GN=Spcs2 PE=1 SV=1)

HSP 1 Score: 160.614 bits (405), Expect = 1.649e-47
Identity = 79/181 (43.65%), Postives = 113/181 (62.43%), Query Frame = 1 
Query:   64 EKAIKVDKWDTNATKNALDDGFKKILKEQFKFEEKFSLIDGRLLISTISVLCGGVAVLFDWLYPFPASKLVLIICVLLYFILTGLLTCYIMFMERSTFFLAHEKDTAGIDKPIKWNFQSRMKKYQDKYELNVTREDLNTNQVAHMTEKRSIADFFDIKGNLRMDLLEKYVLTLKTNLESKK 606
            +K +K+DKWD +A KN+LDD  KK+L E++K+ E F LIDGRL I TIS     VA+++D+++PFP SK VL +CV+ YF++ G+LT Y  + E+S F +AH KD  G+D    W   S +K++ DKY L +T     T Q       +SIA FFD  G L MD  E  +  L  +L +++
Sbjct:   43 DKPVKIDKWDGSAVKNSLDDSAKKVLLEKYKYVENFGLIDGRLTICTISCFFAIVALIWDYMHPFPESKPVLALCVISYFVMMGILTIYTSYKEKSIFLVAHRKDPTGMDPDDIWQLSSSLKRFDDKYTLKLTFISGRTKQQREAEFTKSIAKFFDHSGTLVMDAYEPEISRLHDSLATER 223
[Close]
BLAST of Signal peptidase complex subunit 2 vs. UniProt/SwissProt
Match: sp|Q5RAY6|SPCS2_PONAB (Signal peptidase complex subunit 2 OS=Pongo abelii OX=9601 GN=SPCS2 PE=2 SV=1)

HSP 1 Score: 159.073 bits (401), Expect = 5.768e-47
Identity = 79/177 (44.63%), Postives = 110/177 (62.15%), Query Frame = 1 
Query:   64 EKAIKVDKWDTNATKNALDDGFKKILKEQFKFEEKFSLIDGRLLISTISVLCGGVAVLFDWLYPFPASKLVLIICVLLYFILTGLLTCYIMFMERSTFFLAHEKDTAGIDKPIKWNFQSRMKKYQDKYELNVTREDLNTNQVAHMTEKRSIADFFDIKGNLRMDLLEKYVLTLKTNL 594
            +K +K+DKWD +A KN+LDD  KK+L E++K+ E F LIDGRL I TIS     VA+++D+++PFP SK VL +CV+ YF++ G+LT Y  + E+S F +AH KD  G+D    W   S +K++ DKY L +T     T Q       +SIA FFD  G L MD  E  +  L  +L
Sbjct:   43 DKPVKIDKWDGSAVKNSLDDSAKKVLLEKYKYVENFGLIDGRLTICTISCFFAIVALIWDYMHPFPESKPVLALCVISYFVMMGILTIYTSYKEKSIFLVAHRKDPTGMDPDDIWQLSSSLKRFDDKYTLKLTFISGRTKQQREAEFTKSIAKFFDHSGTLVMDAYEPEISRLHDSL 219
[Close]
BLAST of Signal peptidase complex subunit 2 vs. TrEMBL
Match: A0A267FVI3 (Uncharacterized protein OS=Macrostomum lignano OX=282301 GN=BOX15_Mlig001430g4 PE=4 SV=1)

HSP 1 Score: 174.866 bits (442), Expect = 4.090e-51
Identity = 88/178 (49.44%), Postives = 115/178 (64.61%), Query Frame = 1 
Query:   73 IKVDKWDTNATKNALDDGFKKILKEQFKFEEKFSLIDGRLLISTISVLCGGVAVLFDWLYPFPASKLVLIICVLLYFILTGLLTCYIMFMERSTFFLAHEKDTAGIDKPIKWNFQSRMKKYQDKYELNVTREDLNTNQVAHMTEKRSIADFFDIKGNLRMDLLEKYVLTLKTNLESKK 606
            IK+DKWD NA KNALDD  KKI+ E +   E F LIDGRL + +I+V C   A+L+D+LYPFPASK VLIICV  YFILTG+++ Y+++ E   F++  EKD AGID   KW  QS +KKY D+Y L +T     + Q   +    S+ +FFD +G L  DL E  V  LK +L + K
Sbjct:    8 IKIDKWDGNALKNALDDAAKKIMNESYGLVESFKLIDGRLALCSIAVSCSLFALLWDFLYPFPASKTVLIICVACYFILTGVISVYLLYFEGGVFYVGLEKDKAGIDPDDKWTLQSSLKKYDDQYCLKITYTGGVSKQTRSVERVCSVTEFFDEEGTLCYDLYEATVKGLKDSLSADK 185
[Close]
BLAST of Signal peptidase complex subunit 2 vs. TrEMBL
Match: A0A267F085 (Uncharacterized protein OS=Macrostomum lignano OX=282301 GN=BOX15_Mlig001430g1 PE=4 SV=1)

HSP 1 Score: 173.711 bits (439), Expect = 1.278e-50
Identity = 87/178 (48.88%), Postives = 115/178 (64.61%), Query Frame = 1 
Query:   73 IKVDKWDTNATKNALDDGFKKILKEQFKFEEKFSLIDGRLLISTISVLCGGVAVLFDWLYPFPASKLVLIICVLLYFILTGLLTCYIMFMERSTFFLAHEKDTAGIDKPIKWNFQSRMKKYQDKYELNVTREDLNTNQVAHMTEKRSIADFFDIKGNLRMDLLEKYVLTLKTNLESKK 606
            IK+DKWD NA KNALDD  KKI+ E +   E F LIDGRL + +++V C   A+L+D+LYPFPASK VLIICV  YFILTG+++ Y+++ E   F++  EKD AGID   KW  QS +KKY D+Y L +T     + Q   +    S+ +FFD +G L  DL E  V  LK +L + K
Sbjct:    8 IKIDKWDGNALKNALDDAAKKIMNESYGLVESFKLIDGRLALCSMAVSCSLFALLWDFLYPFPASKTVLIICVACYFILTGVISVYLLYFEGGVFYVGLEKDKAGIDPDDKWTLQSSLKKYDDQYCLKITYTGGVSKQTRSVERVCSVTEFFDEEGTLCYDLYEATVKGLKDSLSADK 185
[Close]
BLAST of Signal peptidase complex subunit 2 vs. TrEMBL
Match: A0A267DU08 (Uncharacterized protein OS=Macrostomum lignano OX=282301 GN=BOX15_Mlig025826g3 PE=4 SV=1)

HSP 1 Score: 172.94 bits (437), Expect = 2.247e-50
Identity = 87/178 (48.88%), Postives = 114/178 (64.04%), Query Frame = 1 
Query:   73 IKVDKWDTNATKNALDDGFKKILKEQFKFEEKFSLIDGRLLISTISVLCGGVAVLFDWLYPFPASKLVLIICVLLYFILTGLLTCYIMFMERSTFFLAHEKDTAGIDKPIKWNFQSRMKKYQDKYELNVTREDLNTNQVAHMTEKRSIADFFDIKGNLRMDLLEKYVLTLKTNLESKK 606
            IK+DKWD NA KNALDD  KKI+ E +   E F LIDGRL + +I+V C   A+L+D+LYPFPASK VLIICV  YFILTG+++ Y+++ E   F++  EKD  GID   KW  QS +KKY D+Y L +T     + Q   +    S+ +FFD +G L  DL E  V  LK +L + K
Sbjct:    8 IKIDKWDGNALKNALDDAAKKIMNESYGLVESFKLIDGRLALCSIAVSCSLFALLWDFLYPFPASKTVLIICVACYFILTGVISVYLLYFEGGVFYVGLEKDKTGIDPDDKWTLQSSLKKYDDQYCLKITYTGGVSKQTRSVERVCSVTEFFDEEGTLCYDLYEATVKGLKDSLSADK 185
[Close]
BLAST of Signal peptidase complex subunit 2 vs. TrEMBL
Match: E9GSF7 (Uncharacterized protein OS=Daphnia pulex OX=6669 GN=DAPPUDRAFT_305755 PE=4 SV=1)

HSP 1 Score: 171.014 bits (432), Expect = 1.863e-49
Identity = 83/184 (45.11%), Postives = 117/184 (63.59%), Query Frame = 1 
Query:   61 PEKAIKVDKWDTNATKNALDDGFKKILKEQFKFEEKFSLIDGRLLISTISVLCGGVAVLFDWLYPFPASKLVLIICVLLYFILTGLLTCYIMFMERSTFFLAHEKDTAGIDKPIKWNFQSRMKKYQDKYELNVTREDLNTNQVAHMTEKRSIADFFDIKGNLRMDLLEKYVLTLKTNLESKKTN 612
            P K +KV+KWD  A KNALDD  K++L ++F + E F+L+DGRL I T++V   G A+L+D+L+PFP SK+VL+ CVL YF+L G+LT Y    E+  F   ++KDTAG+D    W   S + KY D+YEL ++ +D  T +V     KRS+A +FD  G L M+ +E  V  L   L S + N
Sbjct:   10 PAKVLKVNKWDGAAVKNALDDAVKEVLVDKFNYTENFALVDGRLAICTLAVGIAGFALLWDYLHPFPESKIVLLACVLGYFLLMGVLTLYTTHKEKGIFVSVYQKDTAGVDPVNSWEASSSLNKYDDQYELVLSYKDGKTKKVREAKSKRSVAQYFDCNGVLLMEYVEPEVSKLHNGLLSGRKN 193
[Close]
BLAST of Signal peptidase complex subunit 2 vs. TrEMBL
Match: A0A162BP07 (Signal peptidase complex subunit 2 OS=Daphnia magna OX=35525 GN=APZ42_010462 PE=4 SV=1)

HSP 1 Score: 167.548 bits (423), Expect = 3.402e-48
Identity = 82/184 (44.57%), Postives = 119/184 (64.67%), Query Frame = 1 
Query:   61 PEKAIKVDKWDTNATKNALDDGFKKILKEQFKFEEKFSLIDGRLLISTISVLCGGVAVLFDWLYPFPASKLVLIICVLLYFILTGLLTCYIMFMERSTFFLAHEKDTAGIDKPIKWNFQSRMKKYQDKYELNVTREDLNTNQVAHMTEKRSIADFFDIKGNLRMDLLEKYVLTLKTNLESKKTN 612
            P K +KV+KWD  A KNALDD  K++L ++F + E F+L+DGRL I T++V   G A+L+D+L+PFP SK+VL++CVL YF+L G+LT Y    E+  F  A++KD+AG D    W   S + KY D YEL ++ +D  T ++     KRS+A +FD  G L M+L+E  V  L  +L S + +
Sbjct:   10 PAKVLKVNKWDGAAVKNALDDAVKEVLVDKFNYTENFALVDGRLAICTLAVGIAGFALLWDYLHPFPQSKIVLLVCVLGYFLLMGVLTLYTTHKEKGIFVSAYQKDSAGGDAVNSWEASSSLNKYDDLYELVLSYKDGKTKKIREAKSKRSVAQYFDDNGVLLMELVEPEVKKLHNSLLSGRKS 193
[Close]
BLAST of Signal peptidase complex subunit 2 vs. Ensembl Cavefish
Match: spcs2 (signal peptidase complex subunit 2 [Source:NCBI gene;Acc:541342])

HSP 1 Score: 153.68 bits (387), Expect = 4.933e-46
Identity = 81/181 (44.75%), Postives = 112/181 (61.88%), Query Frame = 1 
Query:   64 EKAIKVDKWDTNATKNALDDGFKKILKEQFKFEEKFSLIDGRLLISTISVLCGGVAVLFDWLYPFPASKLVLIICVLLYFILTGLLTCYIMFMERSTFFLAHEKDTAGIDKPIKWNFQSRMKKYQDKYELNVTREDLNTNQVAHMTEKRSIADFFDIKGNLRMDLLEKYVLTLKTNLESKK 606
            EK +K+DKWD  A KN+LDD  KK+L E++ + E F+L+DGRL I T+S L   VA+++D+L+PFP SK VL  CV +YFI+ G+LT Y  + E++ F +A +KD AG+D    W   S + K+ D+Y L  +  D  T Q       +S+  FFD  G L MD  EKYV  L   L S+K
Sbjct:   20 EKPVKIDKWDGAAVKNSLDDAAKKVLIEKYGYVENFNLVDGRLFICTVSCLFAIVALVWDYLHPFPESKPVLACCV-IYFIMMGILTLYTSYKEKNIFLVAVQKDPAGMDPDHTWQLSSSL-KFDDQYTLKASFTDGKTKQYRETEFTKSVGVFFDENGTLVMDQYEKYVTKLHDTLTSEK 198
[Close]
BLAST of Signal peptidase complex subunit 2 vs. Ensembl Nematostella
Match: EDO43323 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7RZ11])

HSP 1 Score: 151.754 bits (382), Expect = 1.074e-45
Identity = 81/184 (44.02%), Postives = 112/184 (60.87%), Query Frame = 1 
Query:   61 PEKAIKVDKWDTNATKNALDDGFKKILKEQFKFEEKFSLIDGRLLISTISVLCGGVAVLFDWLYPFPASKLVLIICVLLYFILTGLLTCYIMFMERSTFFLAHEKDTAGIDKPIKWNFQSRMKKYQDKYELNVTREDLNTNQVAHMTEKRSIADFFDIKGNLRMDLLEKYVLTLKTNLESKKTN 612
            PEK +KVDKWD NA KNALDD  KK+L E+F ++E   L D RL I TIS L    A+ +D+LYPFPASK  LI CVL YF +  +LT +  F E++    A EKD AG+     W  +S +K+Y   Y L ++ +D  TN+    + ++S+A +FD  G L  +L EK V  L  +L ++K +
Sbjct:   19 PEKPVKVDKWDGNAVKNALDDAAKKVLTERFGYQEDHKLTDIRLGICTISCLFALGALAYDYLYPFPASKPALIFCVLSYFTMMTILTMFTTFKEKNYIMFAIEKDDAGVGPDHMWTLRSSLKRYDPNYMLTMSYKDGETNREREQSLEKSVASWFDENGVLIFELFEKDVKELHQSLCAEKKD 202
[Close]
BLAST of Signal peptidase complex subunit 2 vs. Ensembl Medaka
Match: spcs2 (signal peptidase complex subunit 2 [Source:NCBI gene;Acc:101161867])

HSP 1 Score: 131.724 bits (330), Expect = 1.009e-37
Identity = 71/181 (39.23%), Postives = 102/181 (56.35%), Query Frame = 1 
Query:   64 EKAIKVDKWDTNATKNALDDGFKKILKEQFKFEEKFSLIDGRLLISTISVLCGGVAVLFDWLYPFPASKLVLIICVLLYFILTGLLTCYIMFMERSTFFLAHEKDTAGIDKPIKWNFQSRMKKYQDKYELNVTREDLNTNQVAHMTEKRSIADFFDIKGNLRMDLLEKYVLTLKTNLESKK 606
            EK +K+DKWD  A KN+LDD  KK+L E++ + E F L+DGRLLI T+S L   +A+++D+L+PFP S+ VL  CV                 E++ F +A ++D AG+D    W   S +K++ D+Y L V+  D  T +       +S++ FFD  G L MD  EK V  L   L S K
Sbjct:   19 EKPVKIDKWDGAAVKNSLDDAAKKVLLEKYGYVENFQLVDGRLLICTVSCLFAMLALVWDYLHPFPESRPVLACCV-----------------EKNIFLVALQRDPAGMDPDHVWQLASSLKRFDDQYSLRVSFTDGKTRRSREADFTKSVSAFFDQNGTLVMDQFEKSVSRLHDALASDK 182
[Close]
BLAST of Signal peptidase complex subunit 2 vs. Planmine SMEST
Match: SMESG000032194.1 (SMESG000032194.1)

HSP 1 Score: 379.022 bits (972), Expect = 3.011e-135
Identity = 185/185 (100.00%), Postives = 185/185 (100.00%), Query Frame = 1 
Query:   58 MPEKAIKVDKWDTNATKNALDDGFKKILKEQFKFEEKFSLIDGRLLISTISVLCGGVAVLFDWLYPFPASKLVLIICVLLYFILTGLLTCYIMFMERSTFFLAHEKDTAGIDKPIKWNFQSRMKKYQDKYELNVTREDLNTNQVAHMTEKRSIADFFDIKGNLRMDLLEKYVLTLKTNLESKKTN 612
            MPEKAIKVDKWDTNATKNALDDGFKKILKEQFKFEEKFSLIDGRLLISTISVLCGGVAVLFDWLYPFPASKLVLIICVLLYFILTGLLTCYIMFMERSTFFLAHEKDTAGIDKPIKWNFQSRMKKYQDKYELNVTREDLNTNQVAHMTEKRSIADFFDIKGNLRMDLLEKYVLTLKTNLESKKTN
Sbjct:    1 MPEKAIKVDKWDTNATKNALDDGFKKILKEQFKFEEKFSLIDGRLLISTISVLCGGVAVLFDWLYPFPASKLVLIICVLLYFILTGLLTCYIMFMERSTFFLAHEKDTAGIDKPIKWNFQSRMKKYQDKYELNVTREDLNTNQVAHMTEKRSIADFFDIKGNLRMDLLEKYVLTLKTNLESKKTN 185
The following BLAST results are available for this feature:
BLAST of Signal peptidase complex subunit 2 vs. Ensembl Human
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Human e!99)
Total hits: 5
Match NameE-valueIdentityDescription
SPCS21.295e-4744.63signal peptidase complex subunit 2 [Source:HGNC Sy... [more]
SPCS22.564e-4744.63signal peptidase complex subunit 2 [Source:HGNC Sy... [more]
SPCS28.658e-4644.38signal peptidase complex subunit 2 [Source:HGNC Sy... [more]
SPCS25.575e-3648.74signal peptidase complex subunit 2 [Source:HGNC Sy... [more]
SPCS23.086e-938.10signal peptidase complex subunit 2 [Source:HGNC Sy... [more]
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BLAST of Signal peptidase complex subunit 2 vs. Ensembl Celegans
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99)
Total hits: 2
Match NameE-valueIdentityDescription
spcs-22.773e-2534.44Probable signal peptidase complex subunit 2 [Sour... [more]
spcs-22.773e-2534.44Probable signal peptidase complex subunit 2 [Sour... [more]
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BLAST of Signal peptidase complex subunit 2 vs. Ensembl Fly
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99)
Total hits: 3
Match NameE-valueIdentityDescription
Spase257.677e-2934.78gene:FBgn0030306 transcript:FBtr0340293[more]
Spase257.677e-2934.78gene:FBgn0030306 transcript:FBtr0073506[more]
Spase257.677e-2934.78gene:FBgn0030306 transcript:FBtr0340294[more]
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BLAST of Signal peptidase complex subunit 2 vs. Ensembl Zebrafish
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99)
Total hits: 2
Match NameE-valueIdentityDescription
spcs26.290e-4944.20signal peptidase complex subunit 2 [Source:NCBI ge... [more]
spcs23.050e-4843.65signal peptidase complex subunit 2 [Source:NCBI ge... [more]
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BLAST of Signal peptidase complex subunit 2 vs. Ensembl Xenopus
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99)
Total hits: 0
Match NameE-valueIdentityDescription
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BLAST of Signal peptidase complex subunit 2 vs. Ensembl Mouse
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99)
Total hits: 5
Match NameE-valueIdentityDescription
Spcs21.121e-4843.65signal peptidase complex subunit 2 homolog (S. cer... [more]
Spcs22.358e-4843.65signal peptidase complex subunit 2 homolog (S. cer... [more]
Spcs24.119e-4843.65signal peptidase complex subunit 2 homolog (S. cer... [more]
Spcs25.257e-4843.65signal peptidase complex subunit 2 homolog (S. cer... [more]
Spcs23.111e-3747.97signal peptidase complex subunit 2 homolog (S. cer... [more]
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BLAST of Signal peptidase complex subunit 2 vs. UniProt/SwissProt
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt)
Total hits: 5
Match NameE-valueIdentityDescription
sp|Q5M8Y1|SPCS2_XENTR1.588e-4946.41Probable signal peptidase complex subunit 2 OS=Xen... [more]
sp|Q5BJI9|SPCS2_DANRE9.487e-4844.20Probable signal peptidase complex subunit 2 OS=Dan... [more]
sp|Q28250|SPCS2_CANLF1.614e-4743.65Signal peptidase complex subunit 2 OS=Canis lupus ... [more]
sp|Q9CYN2|SPCS2_MOUSE1.649e-4743.65Signal peptidase complex subunit 2 OS=Mus musculus... [more]
sp|Q5RAY6|SPCS2_PONAB5.768e-4744.63Signal peptidase complex subunit 2 OS=Pongo abelii... [more]
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BLAST of Signal peptidase complex subunit 2 vs. TrEMBL
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL)
Total hits: 5
Match NameE-valueIdentityDescription
A0A267FVI34.090e-5149.44Uncharacterized protein OS=Macrostomum lignano OX=... [more]
A0A267F0851.278e-5048.88Uncharacterized protein OS=Macrostomum lignano OX=... [more]
A0A267DU082.247e-5048.88Uncharacterized protein OS=Macrostomum lignano OX=... [more]
E9GSF71.863e-4945.11Uncharacterized protein OS=Daphnia pulex OX=6669 G... [more]
A0A162BP073.402e-4844.57Signal peptidase complex subunit 2 OS=Daphnia magn... [more]
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BLAST of Signal peptidase complex subunit 2 vs. Ensembl Cavefish
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99)
Total hits: 1
Match NameE-valueIdentityDescription
spcs24.933e-4644.75signal peptidase complex subunit 2 [Source:NCBI ge... [more]
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BLAST of Signal peptidase complex subunit 2 vs. Ensembl Sea Lamprey
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99)
Total hits: 0
Match NameE-valueIdentityDescription
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BLAST of Signal peptidase complex subunit 2 vs. Ensembl Yeast
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46)
Total hits: 0
Match NameE-valueIdentityDescription
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BLAST of Signal peptidase complex subunit 2 vs. Ensembl Nematostella
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46)
Total hits: 1
Match NameE-valueIdentityDescription
EDO433231.074e-4544.02Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7... [more]
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BLAST of Signal peptidase complex subunit 2 vs. Ensembl Medaka
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99)
Total hits: 1
Match NameE-valueIdentityDescription
spcs21.009e-3739.23signal peptidase complex subunit 2 [Source:NCBI ge... [more]
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BLAST of Signal peptidase complex subunit 2 vs. Planmine SMEST
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST)
Total hits: 1
Match NameE-valueIdentityDescription
SMESG000032194.13.011e-135100.00SMESG000032194.1[more]
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Sequences
The following sequences are available for this feature:

transcript sequence

>SMED30010710 ID=SMED30010710|Name=Signal peptidase complex subunit 2|organism=Schmidtea mediterranea sexual|type=transcript|length=777bp
TGTAACACGCATCTTTTTAATTATATTTACGTCATTTTATAGATAACATT
ATTATAGATGCCGGAAAAAGCCATTAAAGTCGATAAGTGGGATACTAATG
CTACTAAAAATGCTTTGGATGATGGATTCAAGAAGATATTGAAAGAGCAA
TTTAAATTTGAAGAAAAGTTTTCGTTAATTGATGGTAGGTTGCTAATAAG
TACAATTTCTGTTCTATGTGGTGGTGTCGCAGTTCTGTTTGATTGGCTGT
ATCCATTCCCAGCGTCAAAATTAGTGTTAATAATTTGTGTTTTATTGTAT
TTTATATTAACTGGTCTTTTGACGTGTTATATTATGTTCATGGAAAGGTC
TACCTTCTTTTTAGCTCATGAAAAAGATACTGCTGGAATTGATAAACCAA
TTAAATGGAATTTTCAGTCTCGAATGAAGAAATATCAGGATAAATATGAA
TTGAATGTTACTCGTGAAGATCTGAACACAAATCAGGTAGCACACATGAC
GGAAAAACGATCAATTGCCGATTTTTTCGACATCAAAGGCAATTTACGAA
TGGACTTATTGGAGAAATACGTTTTAACACTAAAAACAAATTTAGAATCC
AAGAAAACCAACTAAGGAAACCGCCGAAATATTGGATTTTTATGATTTTG
TGGTGAGAGTGTGTGTATGTGATTGTGTGTGTGTTTTATGCCTAGCAATG
AGTCTGTTAAATTTGGTAAAATGTTAATGTTTTTTTTTGTATTTTTGTCT
TGTGCAAATATATTCAGTTGAATTTCT
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protein sequence of SMED30010710-orf-1

>SMED30010710-orf-1 ID=SMED30010710-orf-1|Name=SMED30010710-orf-1|organism=Schmidtea mediterranea sexual|type=polypeptide|length=186bp
MPEKAIKVDKWDTNATKNALDDGFKKILKEQFKFEEKFSLIDGRLLISTI
SVLCGGVAVLFDWLYPFPASKLVLIICVLLYFILTGLLTCYIMFMERSTF
FLAHEKDTAGIDKPIKWNFQSRMKKYQDKYELNVTREDLNTNQVAHMTEK
RSIADFFDIKGNLRMDLLEKYVLTLKTNLESKKTN*
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Annotated Terms
The following terms have been associated with this transcript:
Vocabulary: Planarian Anatomy
TermDefinition
PLANA:0002032epidermal cell
Vocabulary: INTERPRO
TermDefinition
IPR009582SigPept_cplx_su2
Vocabulary: biological process
TermDefinition
GO:0006465signal peptide processing
GO:0006508proteolysis
GO:0045047protein targeting to ER
Vocabulary: cellular component
TermDefinition
GO:0005787signal peptidase complex
GO:0016021integral component of membrane
GO:0005783endoplasmic reticulum
GO:0005789endoplasmic reticulum membrane
GO:0016020membrane
GO:0031090organelle membrane
GO:0043231intracellular membrane-bounded organelle
Vocabulary: molecular function
TermDefinition
GO:0008233peptidase activity
GO:0016787hydrolase activity
InterPro
Analysis Name: Schmidtea mediteranean smed_20140614 Interproscan
Date Performed: 2020-05-01
IPR TermIPR DescriptionSourceSource TermSource DescriptionAlignment
IPR009582Signal peptidase complex subunit 2PFAMPF06703SPC25coord: 17..174
e-value: 2.7E-39
score: 134.5
IPR009582Signal peptidase complex subunit 2PANTHERPTHR13085MICROSOMAL SIGNAL PEPTIDASE 25 KDA SUBUNITcoord: 4..183
NoneNo IPR availableTMHMMTMhelixcoord: 72..94
NoneNo IPR availableTMHMMTMhelixcoord: 45..67