Hydrolase_4 domain-containing protein

Overview
NameHydrolase_4 domain-containing protein
Smed IDSMED30010564
Length (bp)1193
Neoblast Clusters

Zeng et. al., 2018



▻ Overview

▻ Neoblast Population

▻ Sub-lethal Irradiated Surviving X1 and X2 Cell Population

 

 

Overview

 

Single cell RNA-seq of pluripotent neoblasts and its early progenies


We isolated X1 neoblasts cells enriched in high piwi-1 expression (Neoblast Population), and profiled ∼7,614 individual cells via scRNA-seq. Unsupervised analyses uncovered 12 distinct classes from 7,088 high-quality cells. We designated these classes Nb1 to Nb12 and ordered them based on high (Nb1) to low (Nb12) piwi-1 expression levels. We further defined groups of genes that best classified the cells parsed into 12 distinct cell clusters to generate a scaled expression heat map of discriminative gene sets for each cluster. Expression of each cluster’s gene signatures was validated using multiplex fluorescence in situ hybridization (FISH) co-stained with piwi-1 and largely confirmed the cell clusters revealed by scRNA-seq.

We also tested sub-lethal irradiation exposure. To profile rare pluripotent stem cells (PSCs) and avoid interference from immediate progenitor cells, we determined a time point after sub-lethal irradiation (7 DPI) with minimal piwi-1+ cells, followed by isolation and single-cell RNA-seq of 1,200 individual cells derived from X1 (Piwi-1 high) and X2 (Piwi-1 low) cell populations (Sub-lethal Irradiated Surviving X1 and X2 Cell Population)



Explore this single cell expression dataset with our NB Cluster Shiny App



 

Neoblast Population

 

t-SNE plot shows two-dimensional representation of global gene expression relationships among all neoblasts (n = 7,088 after filter). Cluster identity was assigned based on the top 10 marker genes of each cluster (Table S2), followed by inspection of RNA in situ hybridization patterns. Neoblast groups, Nb.


Expression of Hydrolase_4 domain-containing protein (SMED30010564) t-SNE clustered cells

Violin plots show distribution of expression levels for Hydrolase_4 domain-containing protein (SMED30010564) in cells (dots) of each of the 12 neoblast clusters.

 

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Sub-lethal Irradiated Surviving X1 and X2 Cell Population

 

t-SNE plot of surviving X1 and X2 cells (n = 1,039 after QC filter) after sub-lethal irradiation. Colors indicate unbiased cell classification via graph-based clustering. SL, sub-lethal irradiated cell groups.

Expression of Hydrolase_4 domain-containing protein (SMED30010564) in the t-SNE clustered sub-lethally irradiated X1 and X2 cells.

Violin plots show distribution of expression levels for Hydrolase_4 domain-containing protein (SMED30010564) in cells (dots) of each of the 10 clusters of sub-leathally irradiated X1 and X2 cells.

 

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Embryonic Expression

Davies et. al., 2017

Hover the mouse over a column in the graph to view average RPKM values per sample.
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Embryonic Stages: Y: yolk. S2-S8: Stages 2-8. C4: asexual adult. SX: virgin, sexually mature adult.
For further information about sample preparation and analysis for the single animal RNA-Seq experiment, please refer to the Materials and Methods

 

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Anatomical Expression

PAGE et. al., 2020



SMED30010564

has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGE



PAGE Curations: 1

  
Expressed InReference TranscriptGene ModelsPublished TranscriptTranscriptomePublicationSpecimenLifecycleEvidence
nervous systemSMED30010564SMESG000015331.1 SMESG000015322.1 dd_Smed_v4_10349_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018		FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
Note: Hover over icons to view figure legend
Homology
[Close]
BLAST of Hydrolase_4 domain-containing protein vs. Ensembl Human
Match: ABHD12 (abhydrolase domain containing 12 [Source:HGNC Symbol;Acc:HGNC:15868])

HSP 1 Score: 200.675 bits (509), Expect = 6.679e-60
Identity = 122/334 (36.53%), Postives = 192/334 (57.49%), Query Frame = 2 
Query:   59 IYLILQVIGLFTVL-IYVIIPFILYIFPHIFSKIIFLDFVY-NIFTKLDKPEXXXXXXXXXXXXKIVNEYSNCELGAWEILSKVDENRKESCSLKQIEFAEKFSNGNPIILYLHGNSMHRGSNHRLLLYHVLRESGFHILTIDYRGFADSSGSIHNEDEALEDAFVAYNYLKLTAPNSSIFLWGHSLGTGISSLLLQKLSKMNECSAISGVILESPFTSILETMDHIGLTWPWRFMPYFDRIFKKALLNQKLAFNSIENLKETNNIILILHAEDDKVLSFKMGKKLYSTLLSAGK----DVYFKGFSSNLKYGHDYIVNCPELPDIIREFTTKA 1042
            ++L L+ I LF VL +Y+ IPF++ + P I +K+IFL+FV    F  L KP++   N         +    +  +G W  +  V    K +    Q+ + +  ++ +PIILYLHGN+  RG +HR+ LY VL   G+H++T DYRG+ DS G+  +E     DA   ++++K  + ++ +++WGHSLGTG+++ L+++L +    +    +ILESPFT+I E       +  +R+ P FD  F   + +  + F + EN+K  +  +LILHAEDD V+ F++G+KLYS    A       V F  F S+L Y H YI   PELP I+REF  K+
Sbjct:   68 VWLRLRKI-LFCVLGLYIAIPFLIKLCPGIQAKLIFLNFVRVPYFIDLKKPQDQGLNHTCNYY---LQPEEDVTIGVWHTVPAV--WWKNAQGKDQMWYEDALASSHPIILYLHGNAGTRGGDHRVELYKVLSSLGYHVVTFDYRGWGDSVGTP-SERGMTYDALHVFDWIKARSGDNPVYIWGHSLGTGVATNLVRRLCERE--TPPDALILESPFTNIREEAKSHPFSVIYRYFPGFDWFFLDPITSSGIKFANDENVKHISCPLLILHAEDDPVVPFQLGRKLYSIAAPARSFRDFKVQFVPFHSDLGYRHKYIYKSPELPRILREFLGKS 392
[Close]
BLAST of Hydrolase_4 domain-containing protein vs. Ensembl Human
Match: ABHD12 (abhydrolase domain containing 12 [Source:HGNC Symbol;Acc:HGNC:15868])

HSP 1 Score: 195.282 bits (495), Expect = 9.364e-58
Identity = 119/328 (36.28%), Postives = 188/328 (57.32%), Query Frame = 2 
Query:   59 IYLILQVIGLFTVL-IYVIIPFILYIFPHIFSKIIFLDFVY-NIFTKLDKPEXXXXXXXXXXXXKIVNEYSNCELGAWEILSKVDENRKESCSLKQIEFAEKFSNGNPIILYLHGNSMHRGSNHRLLLYHVLRESGFHILTIDYRGFADSSGSIHNEDEALEDAFVAYNYLKLTAPNSSIFLWGHSLGTGISSLLLQKLSKMNECSAISGVILESPFTSILETMDHIGLTWPWRFMPYFDRIFKKALLNQKLAFNSIENLKETNNIILILHAEDDKVLSFKMGKKLYSTLLSAGK----DVYFKGFSSNLKYGHDYIVNCPELPDIIR 1024
            ++L L+ I LF VL +Y+ IPF++ + P I +K+IFL+FV    F  L KP++   N         +    +  +G W  +  V    K +    Q+ + +  ++ +PIILYLHGN+  RG +HR+ LY VL   G+H++T DYRG+ DS G+  +E     DA   ++++K  + ++ +++WGHSLGTG+++ L+++L +    +    +ILESPFT+I E       +  +R+ P FD  F   + +  + F + EN+K  +  +LILHAEDD V+ F++G+KLYS    A       V F  F S+L Y H YI   PELP I+R
Sbjct:   68 VWLRLRKI-LFCVLGLYIAIPFLIKLCPGIQAKLIFLNFVRVPYFIDLKKPQDQGLNHTCNYY---LQPEEDVTIGVWHTVPAV--WWKNAQGKDQMWYEDALASSHPIILYLHGNAGTRGGDHRVELYKVLSSLGYHVVTFDYRGWGDSVGT-PSERGMTYDALHVFDWIKARSGDNPVYIWGHSLGTGVATNLVRRLCERE--TPPDALILESPFTNIREEAKSHPFSVIYRYFPGFDWFFLDPITSSGIKFANDENVKHISCPLLILHAEDDPVVPFQLGRKLYSIAAPARSFRDFKVQFVPFHSDLGYRHKYIYKSPELPRILR 386
[Close]
BLAST of Hydrolase_4 domain-containing protein vs. Ensembl Human
Match: ABHD12 (abhydrolase domain containing 12 [Source:HGNC Symbol;Acc:HGNC:15868])

HSP 1 Score: 176.022 bits (445), Expect = 2.577e-52
Identity = 93/236 (39.41%), Postives = 144/236 (61.02%), Query Frame = 2 
Query:  347 FAEKFSNGNPIILYLHGNSMHRGSNHRLLLYHVLRESGFHILTIDYRGFADSSGSIHNEDEALEDAFVAYNYLKLTAPNSSIFLWGHSLGTGISSLLLQKLSKMNECSAISGVILESPFTSILETMDHIGLTWPWRFMPYFDRIFKKALLNQKLAFNSIENLKETNNIILILHAEDDKVLSFKMGKKLYSTLLSAGK----DVYFKGFSSNLKYGHDYIVNCPELPDIIREFTTKA 1042
            + +  ++ +PIILYLHGN+  RG +HR+ LY VL   G+H++T DYRG+ DS G+  +E     DA   ++++K  + ++ +++WGHSLGTG+++ L+++L +    +    +ILESPFT+I E       +  +R+ P FD  F   + +  + F + EN+K  +  +LILHAEDD V+ F++G+KLYS    A       V F  F S+L Y H YI   PELP I+REF  K+
Sbjct:    3 YEDALASSHPIILYLHGNAGTRGGDHRVELYKVLSSLGYHVVTFDYRGWGDSVGTP-SERGMTYDALHVFDWIKARSGDNPVYIWGHSLGTGVATNLVRRLCERE--TPPDALILESPFTNIREEAKSHPFSVIYRYFPGFDWFFLDPITSSGIKFANDENVKHISCPLLILHAEDDPVVPFQLGRKLYSIAAPARSFRDFKVQFVPFHSDLGYRHKYIYKSPELPRILREFLGKS 235
[Close]
BLAST of Hydrolase_4 domain-containing protein vs. Ensembl Human
Match: ABHD12 (abhydrolase domain containing 12 [Source:HGNC Symbol;Acc:HGNC:15868])

HSP 1 Score: 151.754 bits (382), Expect = 2.409e-43
Identity = 82/213 (38.50%), Postives = 127/213 (59.62%), Query Frame = 2 
Query:  416 SNHRLLLYHVLRESGFHILTIDYRGFADSSGSIHNEDEALEDAFVAYNYLKLTAPNSSIFLWGHSLGTGISSLLLQKLSKMNECSAISGVILESPFTSILETMDHIGLTWPWRFMPYFDRIFKKALLNQKLAFNSIENLKETNNIILILHAEDDKVLSFKMGKKLYSTLLSAGK----DVYFKGFSSNLKYGHDYIVNCPELPDIIREFTTKA 1042
             +HR+ LY VL   G+H++T DYRG+ DS G+  +E     DA   ++++K  + ++ +++WGHSLGTG+++ L+++L +    +    +ILESPFT+I E       +  +R+ P FD  F   + +  + F + EN+K  +  +LILHAEDD V+ F++G+KLYS    A       V F  F S+L Y H YI   PELP I+REF  K+
Sbjct:    1 GDHRVELYKVLSSLGYHVVTFDYRGWGDSVGTP-SERGMTYDALHVFDWIKARSGDNPVYIWGHSLGTGVATNLVRRLCERE--TPPDALILESPFTNIREEAKSHPFSVIYRYFPGFDWFFLDPITSSGIKFANDENVKHISCPLLILHAEDDPVVPFQLGRKLYSIAAPARSFRDFKVQFVPFHSDLGYRHKYIYKSPELPRILREFLGKS 210
[Close]
BLAST of Hydrolase_4 domain-containing protein vs. Ensembl Human
Match: ABHD12B (abhydrolase domain containing 12B [Source:HGNC Symbol;Acc:HGNC:19837])

HSP 1 Score: 149.443 bits (376), Expect = 1.307e-41
Identity = 90/271 (33.21%), Postives = 144/271 (53.14%), Query Frame = 2 
Query:  266 NCELGAWEILSK-----VDENRKESCSLKQIEFAEK-FSNGNPIILYLHGNSMHRGSNHRLLLYHVLRESGFHILTIDYRGFADSSGSIHNEDEALEDAFVAYNYLKLTAPNSSIFLWGHSLGTGISSLLLQKLSKMNECSAISGVILESPFTSILETMDHIGLTWPWRFMPYFDRIFKKALLNQKLAFNSIENLKETNNIILILHAEDDKVLSFKMGKKLYSTLLSAGKD-------VYFKGFSSNLKYGHDYIVNCPELPDIIREFTTK 1039
            +C    W+++ +     V   R E    K   + E    +GNPII+YLHG++ HR ++HRL L  VL + GFH+L++DYRGF DS+G    E+    DA   Y + K  +  + + LWGHSLGTG+++   + L +      +  ++LE+PFT++     +  L   +R +P F R    AL   K+ F + EN+K  ++ +LILH EDD+ +  + GKKLY    +A ++       ++  GF  NL      +   P L   +R+F +K
Sbjct:   21 SCVAAWWDMVDRNLRHTVPSCRGEDAKGKDCCWYEAALRDGNPIIVYLHGSAEHRAASHRLKLVKVLSDGGFHVLSVDYRGFGDSTGK-PTEEGLTTDAICVYEWTKARSGITPVCLWGHSLGTGVATNAAKVLEEKG--CPVDAIVLEAPFTNMWVASINYPLLKIYRNIPGFLRTLMDALRKDKIIFPNDENVKFLSSPLLILHGEDDRTVPLEYGKKLYEIARNAYRNKERVKMVIFPPGFQHNL------LCKSPTLLITVRDFLSK 282
[Close]
BLAST of Hydrolase_4 domain-containing protein vs. Ensembl Celegans
Match: abhd-12 (ABHydrolase Domain containing homolog [Source:UniProtKB/TrEMBL;Acc:Q965S2])

HSP 1 Score: 160.999 bits (406), Expect = 9.824e-46
Identity = 108/334 (32.34%), Postives = 174/334 (52.10%), Query Frame = 2 
Query:   50 LMMIYLILQVIGLFTVLIYVIIPFILYIFPHIFSKIIFLDFVYNIFTKLDKPEXXXXXXXXXXXXKIVNEYSNCELGAWEIL-SKVD-ENRKESCSLKQIEFAEKFSNG-NPIILYLHGNSMHRGSNHRLLLYHVLRESGFHILTIDYRGFADSSGSIHNEDEALEDAFVAYNYLKLTAPNSSIFLWGHSLGTGISSLLLQKLSKMNECSAISGVILESPFTSILETMDHIGL----TWPWRFMPYFDRIFKKALLNQKLAFNSIENLKETNNIILILHAEDDKVLSFKMGKKLYSTLLSAGKDVYFKGFSSNLKYGHDYIVNCPELPDIIREF 1030
            +++I  +L  I +  + I + +P ++Y  P     I FL+F        D  +  + N ++      +   S   +G W IL +K+  E R E     + +F +   +  N II Y HGNS  R   HR+ +Y++L +  +H++  DYRG+ DS G+   E   +ED    Y +LK     + + +WGHS+GTG+S  L+Q LS+  E     G+ILESPF ++ + + +  +    +W   FM   D I  + L +  L   S + ++  +  I+ILHAEDDK+L  K+G+ LY     A +D+  + FSS+   GH +I   PELP+II EF
Sbjct:    6 IVLIQPLLLCITILVLSIVIFLPILVYFLPRYTQFIFFLNF--RRLPNTDYNDLASNNVKSIGRSLHLPGKSG-RIGVWHILPNKLSLEWRTEGKHPTERDFDDMMRDSENQIIFYAHGNSFDRTFYHRVEMYNLLSDCNYHVVCFDYRGYGDSEGT-PTEKGIVEDTKTVYEWLKENCGKTPVIVWGHSMGTGVSCKLVQDLSR--EQQPPCGLILESPFNNLKDAVTNHPIFTVFSWMNDFM--VDHIIIRPLNSVGLTMRSDKRIRLVSCPIIILHAEDDKILPVKLGRALYEAAKDAERDIKIREFSSDYGLGHKFICRYPELPEIIEEF 331
[Close]
BLAST of Hydrolase_4 domain-containing protein vs. Ensembl Celegans
Match: abhd-12 (ABHydrolase Domain containing homolog [Source:UniProtKB/TrEMBL;Acc:Q965S2])

HSP 1 Score: 160.999 bits (406), Expect = 9.824e-46
Identity = 108/334 (32.34%), Postives = 174/334 (52.10%), Query Frame = 2 
Query:   50 LMMIYLILQVIGLFTVLIYVIIPFILYIFPHIFSKIIFLDFVYNIFTKLDKPEXXXXXXXXXXXXKIVNEYSNCELGAWEIL-SKVD-ENRKESCSLKQIEFAEKFSNG-NPIILYLHGNSMHRGSNHRLLLYHVLRESGFHILTIDYRGFADSSGSIHNEDEALEDAFVAYNYLKLTAPNSSIFLWGHSLGTGISSLLLQKLSKMNECSAISGVILESPFTSILETMDHIGL----TWPWRFMPYFDRIFKKALLNQKLAFNSIENLKETNNIILILHAEDDKVLSFKMGKKLYSTLLSAGKDVYFKGFSSNLKYGHDYIVNCPELPDIIREF 1030
            +++I  +L  I +  + I + +P ++Y  P     I FL+F        D  +  + N ++      +   S   +G W IL +K+  E R E     + +F +   +  N II Y HGNS  R   HR+ +Y++L +  +H++  DYRG+ DS G+   E   +ED    Y +LK     + + +WGHS+GTG+S  L+Q LS+  E     G+ILESPF ++ + + +  +    +W   FM   D I  + L +  L   S + ++  +  I+ILHAEDDK+L  K+G+ LY     A +D+  + FSS+   GH +I   PELP+II EF
Sbjct:    6 IVLIQPLLLCITILVLSIVIFLPILVYFLPRYTQFIFFLNF--RRLPNTDYNDLASNNVKSIGRSLHLPGKSG-RIGVWHILPNKLSLEWRTEGKHPTERDFDDMMRDSENQIIFYAHGNSFDRTFYHRVEMYNLLSDCNYHVVCFDYRGYGDSEGT-PTEKGIVEDTKTVYEWLKENCGKTPVIVWGHSMGTGVSCKLVQDLSR--EQQPPCGLILESPFNNLKDAVTNHPIFTVFSWMNDFM--VDHIIIRPLNSVGLTMRSDKRIRLVSCPIIILHAEDDKILPVKLGRALYEAAKDAERDIKIREFSSDYGLGHKFICRYPELPEIIEEF 331
[Close]
BLAST of Hydrolase_4 domain-containing protein vs. Ensembl Celegans
Match: Y41E3.18 (pep chromosome:WBcel235:IV:15061929:15065748:-1 gene:WBGene00044003.1 transcript:Y41E3.18.1 gene_biotype:protein_coding transcript_biotype:protein_coding gene_symbol:Y41E3.18)

HSP 1 Score: 52.7582 bits (125), Expect = 2.912e-7
Identity = 59/241 (24.48%), Postives = 105/241 (43.57%), Query Frame = 2 
Query:  347 FAEKFSNGNPIILYLHGNSMHRGSNHRLLLYHVLRESGFH---ILTIDYRGFADSSGSIHNEDEALEDAFVAYNYLKL--TAPNSSIFLWGHSLGTGISSLLLQKLSKMNECSAISGVILESPFTSILETMDHIGLTWPWRFMPYFDRIFKKALLNQKLAFNSIENLKETNNIILILHAEDDKVLSFKMGKKLYSTLLSAGKDVYFKGFSSNLKYGHDYIVNCPELPDIIREFTTKAINTK 1054
            FA +F+     +LY H N     S+H + +  ++  + F+   + + DY G+   SG I +E     D    Y ++ L        I L G+S+G+  +  LL    +  +    +GVIL++P TSIL  +  +        M     + KK     +  F +I+ + E    IL++H + DK +  + GK +    ++     +  G +      HD + NC E+   +R F    +N K
Sbjct:  268 FAPRFT-----LLYSHPNGSDL-SDHLIGIPSLIDIARFYRCEVYSYDYTGYG-ISGGIASESNLYSDIQAIYEHITLEKRVDPKKIVLLGYSIGSAATIELL----RHEQDQKPAGVILQAPPTSILRVIGGM--------MGRTKHLEKKTCCIDR--FVTIDKIHEIQIPILVIHGKADKTVPVEHGKLICQRAITKVAPEWVPGAA------HDNVENCREVWRRVRRFVKVELNLK 481
[Close]
BLAST of Hydrolase_4 domain-containing protein vs. Ensembl Celegans
Match: aho-3 (Alpha/beta hydrolase domain-containing protein aho-3 [Source:UniProtKB/Swiss-Prot;Acc:Q21221])

HSP 1 Score: 50.8322 bits (120), Expect = 7.449e-7
Identity = 51/202 (25.25%), Postives = 82/202 (40.59%), Query Frame = 2 
Query:  380 ILYLHGNSMHRGSNHRLLLYHVLRESGFH----ILTIDYRGFADSSGSIHNEDEALEDAFVAYNYLK--LTAPNSSIFLWGHSLGTGISSLLLQKLSKMNECSAISGVILESPFTSILETMDHIGLTWPWRFMPYFDRIFKKALLNQKLAFNSIENLKETNNIILILHAEDDKVLSFKMGKKLYSTLLSAGKDVYFKGFSSN 967
            +L+ HGN++  G      LY +    GFH    + + DY G+  S+G   +E     D   A+  LK     P   I L+G S+GT  S  L  +         ++ ++L SP  S +  +   G T  W                   AF SIE +       L++H  DD+V+ F  G  +Y    ++ + ++  G   N
Sbjct:  115 LLFSHGNAVDLG-QMTSFLYGL----GFHLNCNVFSYDYSGYGCSTGK-PSEKNLYADITAAFELLKSEFGVPKEKIILYGQSIGTVPSVDLASR-------EDLAALVLHSPLMSGMR-VAFPGTTTTWCCD----------------AFPSIEKVPRVKCPTLVIHGTDDEVIDFSHGVSIYERCPTSVEPLWVPGAGHN 286
[Close]
BLAST of Hydrolase_4 domain-containing protein vs. Ensembl Fly
Match: CG15111 (gene:FBgn0034419 transcript:FBtr0086581)

HSP 1 Score: 165.622 bits (418), Expect = 5.678e-47
Identity = 86/226 (38.05%), Postives = 131/226 (57.96%), Query Frame = 2 
Query:  368 GNPIILYLHGNSMHRGSNHRLLLYHVLRESGFHILTIDYRGFADSSGSIHNEDEALEDAFVAYNYLKLTAPNSSIFLWGHSLGTGISSLLLQKLSKMNECSAISGVILESPFTSILETMDHIGLTWPWRFMPYFDRIFKKALLNQKLAFNSIENLKETNNIILILHAEDDKVLSFKMGKKLYSTLLSA----GKDVYFKGFSSNLKYGHDYIVNCPELPDIIREFT 1033
            G  ++LYLHGN+  RGS HR  +Y +LR+  +H+ + DYRG+ADS      E+  + DA + + Y+  T  N  I +WGHSLGTG+++ L  KL+ + E  A  GVILESPFT+I + +        ++ +P+F+    + +   +L F S  ++ E    I+I+HAEDD V+ F +G +LY   L         V F  F ++ KYGH Y+   PELP +I++F 
Sbjct:  162 GGTVVLYLHGNTASRGSGHRSEVYKLLRKLNYHVFSFDYRGYADSDPVPPTEEGVVRDAMMVFEYIANTTSN-PIVVWGHSLGTGVATHLCAKLASLRE-RAPRGVILESPFTNIRDEIRMHPFAKLYKNLPWFNFTISQPMYTNRLRFESDVHVLEFRQPIMIIHAEDDVVVPFNLGYRLYRIALDGRSRTSGPVEFHRFGASRKYGHKYLCRAPELPGLIQKFV 385
[Close]
BLAST of Hydrolase_4 domain-containing protein vs. Ensembl Fly
Match: CG15111 (gene:FBgn0034419 transcript:FBtr0086580)

HSP 1 Score: 165.622 bits (418), Expect = 1.021e-46
Identity = 86/226 (38.05%), Postives = 131/226 (57.96%), Query Frame = 2 
Query:  368 GNPIILYLHGNSMHRGSNHRLLLYHVLRESGFHILTIDYRGFADSSGSIHNEDEALEDAFVAYNYLKLTAPNSSIFLWGHSLGTGISSLLLQKLSKMNECSAISGVILESPFTSILETMDHIGLTWPWRFMPYFDRIFKKALLNQKLAFNSIENLKETNNIILILHAEDDKVLSFKMGKKLYSTLLSA----GKDVYFKGFSSNLKYGHDYIVNCPELPDIIREFT 1033
            G  ++LYLHGN+  RGS HR  +Y +LR+  +H+ + DYRG+ADS      E+  + DA + + Y+  T  N  I +WGHSLGTG+++ L  KL+ + E  A  GVILESPFT+I + +        ++ +P+F+    + +   +L F S  ++ E    I+I+HAEDD V+ F +G +LY   L         V F  F ++ KYGH Y+   PELP +I++F 
Sbjct:  180 GGTVVLYLHGNTASRGSGHRSEVYKLLRKLNYHVFSFDYRGYADSDPVPPTEEGVVRDAMMVFEYIANTTSN-PIVVWGHSLGTGVATHLCAKLASLRE-RAPRGVILESPFTNIRDEIRMHPFAKLYKNLPWFNFTISQPMYTNRLRFESDVHVLEFRQPIMIIHAEDDVVVPFNLGYRLYRIALDGRSRTSGPVEFHRFGASRKYGHKYLCRAPELPGLIQKFV 403
[Close]
BLAST of Hydrolase_4 domain-containing protein vs. Ensembl Zebrafish
Match: abhd12 (abhydrolase domain containing 12 [Source:NCBI gene;Acc:767657])

HSP 1 Score: 194.126 bits (492), Expect = 1.046e-57
Identity = 117/326 (35.89%), Postives = 180/326 (55.21%), Query Frame = 2 
Query:   71 LQVIGLFTVLIYVIIPFILYIFPHIFSKIIFLDFVY-NIFTKLDKPEXXXXXXXXXXXXKIVNEYSNCELGAWEILSKVDENRKESCSLKQIEFAEK-FSNGNPIILYLHGNSMHRGSNHRLLLYHVLRESGFHILTIDYRGFADSSGSIHNEDEALEDAFVAYNYLKLTAPNSSIFLWGHSLGTGISSLLLQKLSKMNECSAISGVILESPFTSILETMDHIGLTWPWRFMPYFDRIFKKALLNQKLAFNSIENLKETNNIILILHAEDDKVLSFKMGKKLYSTLLSA----GKDVYFKGFSSNLKYGHDYIVNCPELPDIIREF 1030
            L+ I ++ + IY+ IP I+ + P I +K++FL+FV    F  L +P++   N  +      +       +G W     V          K  E+ EK F + +P+ILYLHGN+  RG +HR+ LY VL   G+H++T DYRG+ DS GS  +E     DA   Y ++K       +++WGHSLGTG+++ L+++L   +  +    +ILESPFT+I E       +  +R++P FD  F  A+    + F S EN+   +  +LILHAEDD V+ F++GKKLY     +    G  V F  FSS+L Y H +I   P+LP+I+ +F
Sbjct:   58 LRRILIWLLGIYIAIPVIIKVCPSIQAKLVFLNFVRVPYFIDLKRPQDQGMNHTHNF---YLQPEEGINIGVWHT---VPAGMWREAQAKDAEWYEKSFQSSHPVILYLHGNAGTRGGDHRVQLYKVLSSLGYHVVTFDYRGWGDSEGSP-SERGMTSDALFLYQWIKQRIGPKPLYIWGHSLGTGVATNLVRRLC--DRGTPPDALILESPFTNIREEAKSHPFSMVYRYLPGFDWFFLDAISANDIRFASDENVNHISCPVLILHAEDDTVVPFQLGKKLYDLAAQSKSLNGHKVQFIPFSSSLGYRHKFIYKSPQLPNILSDF 374
[Close]
BLAST of Hydrolase_4 domain-containing protein vs. Ensembl Zebrafish
Match: AL953905.1 (pep chromosome:GRCz11:CHR_ALT_CTG17_1_12:21174970:21187708:-1 gene:ENSDARG00000116702.1 transcript:ENSDART00000193692.1 gene_biotype:protein_coding transcript_biotype:protein_coding gene_symbol:AL953905.1)

HSP 1 Score: 162.54 bits (410), Expect = 4.572e-46
Identity = 97/260 (37.31%), Postives = 143/260 (55.00%), Query Frame = 2 
Query:  275 LGAWEILSKVDENRKESCSLKQIEFAEK-FSNGNPIILYLHGNSMHRGSNHRLLLYH----VLRESGFHILTIDYRGFADSSGSIHNEDEALEDAFVAYNYLKLTAPNSSIFLWGHSLGTGISSLLLQKLSKMNECSAISGVILESPFTSILETMDHIGLTWPWRFMPYFDRIFKKALLNQKLAFNSIENLKETNNIILILHAEDDKVLSFKMGKKLYSTLLSA----GKDVYFKGFSSNLKYGHDYIVNCPELPDIIRE 1027
            +G W     V          K  E+ EK F + +P+ILYLHGN+  R +N  L+L      VL   G+H++T DYRG+ DS GS  +E     DA   Y ++K       +++WGHSLGTG+++ L+++L   +  +    +ILESPFT+I E       +  +R++P FD  F  A+    + F S EN+   +  +LILHAEDD V+ F++GKKLY     +    G  V F  FSS+L Y H +I   P+LP+I+ E
Sbjct:   95 IGVWHT---VPAGMWREAQAKDAEWYEKSFQSSHPVILYLHGNAGTRYTNTHLILIKPTNTVLSSLGYHVVTFDYRGWGDSEGSP-SERGMTSDALFLYQWIKQRIGPKPLYIWGHSLGTGVATNLVRRLC--DRGTPPDALILESPFTNIREEAKSHPFSMVYRYLPGFDWFFLDAISANDIRFASDENVNHISCPVLILHAEDDTVVPFQLGKKLYDLAAQSKSLNGHKVQFIPFSSSLGYRHKFIYKSPQLPNILSE 348
[Close]
BLAST of Hydrolase_4 domain-containing protein vs. Ensembl Zebrafish
Match: si:ch211-117n7.7 (si:ch211-117n7.7 [Source:ZFIN;Acc:ZDB-GENE-060503-569])

HSP 1 Score: 146.362 bits (368), Expect = 5.627e-40
Identity = 101/329 (30.70%), Postives = 162/329 (49.24%), Query Frame = 2 
Query:   80 IGLFTVLIY-VIIPFILYIFPHI----FSKIIFLDFVYNIFTKLDKPEXXXXXXXXXXXXKIVNEYSNCELGAWEILSKVDENRKESCSLKQIEFAEK-FSNGNPIILYLHGNSMHRGSNHRLLLYHVLRESGFHILTIDYRGFADSSGSIHNEDEALEDAFVAYNYLKLTAPNSSIFLWGHSLGTGISSLLLQKLSKMNECSAISGVILESPFTSILETMDHI---GLTWPWRFMPYFDRIFKKALLNQKLAFNSIENLKETNNIILILHAEDDKVLSFKMGKKLYSTLLSA-GKDVYFKGFSSNLKYG--HDYIVNCPELPDIIREF 1030
            IGL ++LI    IPF+L++F  I        + L+   N + K ++                        +G W     V E+R +    K +E+ EK   +G+PI +YLHGN+ +R + HR+ + ++L   G+H L +DYRGF DS+G    E     DA   YN++K  + NS + +WGHSLG+G+++    KL  + +     G+ILE  F S     D +     TW +   PY        + N  L F + +NL++  + I+ILH+EDD ++   + +++Y     A   D   K    + KYG  H+ +   P LP+I+REF
Sbjct:   40 IGLVSLLILGATIPFLLHVFSDIDDLSRPSDLGLNHTINFYLKTEE---------------------GVRVGVWHT---VPEHRWKEAQGKNVEWYEKALGDGSPIFMYLHGNTGNRSAPHRIGVANILSALGYHALVMDYRGFGDSTGEP-TEPGLTTDALYLYNWIKKRSGNSLLCVWGHSLGSGVTTNTAVKL--LEQGKKFDGIILEGAFLSGRMAADQVFEHPFTWYYWKFPYIQYFLFNPMKNNNLDFPTDKNLEKIRSPIMILHSEDDHIVPMSVAQEIYRIAKKAQNSDERVKLVPFDGKYGYLHNGLYRDPALPNIVREF 341
[Close]
BLAST of Hydrolase_4 domain-containing protein vs. Ensembl Zebrafish
Match: si:ch211-117n7.6 (si:ch211-117n7.6 [Source:ZFIN;Acc:ZDB-GENE-060503-474])

HSP 1 Score: 134.806 bits (338), Expect = 1.072e-35
Identity = 86/261 (32.95%), Postives = 132/261 (50.57%), Query Frame = 2 
Query:  266 NCELGAWEILSKVDENRKESCSLKQIEFAEK-FSNGNPIILYLHGNSMHRGSNHRLLLYHVLRESGFHILTIDYRGFADSSGSIHNEDEALEDAFVAYNYLKLTAPNSSIFLWGHSLGTGISSLLLQKLSKMNECSAISGVILESPFTSILETMDHIGLTWPWRF--MPYFDRIFKKALLNQKLAFNSIENLKETNNIILILHAEDDKVLSFKMGKKLYSTLLSA---GKDVYFKGFSSNLKYGHDYIVNCPELPDIIREF 1030
               +G W     V E+R +    K  E+ EK   +G+PI +YLHGN  +R + HR+ + +VL   G+H+L +DYRGF DS+G    E     DA   YN++K  + NS + +WGHS+G+G+++ +  KL  + E     G+ILE    S        G  + W +   PY        L N K+ F   ENL++    ILILH++DD V  F + +++Y     A    + V    F     Y H+ +     LP+++REF
Sbjct:   84 GVRVGVWHT---VPEHRWKEAQGKNAEWYEKALGDGSPIFIYLHGNGGNRSALHRIGVANVLSALGYHVLVMDYRGFGDSTGEP-TEPGLTTDALYLYNWIKKRSGNSLVCVWGHSIGSGVTTNVAVKL--LEEGKKFDGIILEGAMLSGRAAAKQYGHPFSWFYWKFPYIQFFLFNPLKNNKIVFPLDENLEKIRTPILILHSKDDHVSPFSVAQEIYRIAKKAQNSDERVKLVLFDGKHGYLHNGLYRDHRLPNMLREF 338
[Close]
BLAST of Hydrolase_4 domain-containing protein vs. Ensembl Zebrafish
Match: si:ch211-117n7.7 (si:ch211-117n7.7 [Source:ZFIN;Acc:ZDB-GENE-060503-569])

HSP 1 Score: 134.42 bits (337), Expect = 1.359e-35
Identity = 99/329 (30.09%), Postives = 156/329 (47.42%), Query Frame = 2 
Query:   80 IGLFTVLIY-VIIPFILYIFPHI----FSKIIFLDFVYNIFTKLDKPEXXXXXXXXXXXXKIVNEYSNCELGAWEILSKVDENRKESCSLKQIEFAEK-FSNGNPIILYLHGNSMHRGSNHRLLLYHVLRESGFHILTIDYRGFADSSGSIHNEDEALEDAFVAYNYLKLTAPNSSIFLWGHSLGTGISSLLLQKLSKMNECSAISGVILESPFTSILETMDHI---GLTWPWRFMPYFDRIFKKALLNQKLAFNSIENLKETNNIILILHAEDDKVLSFKMGKKLYSTLLSA-GKDVYFKGFSSNLKYG--HDYIVNCPELPDIIREF 1030
            IGL ++LI    IPF+L++F  I        + L+   N + K ++                        +G W     V E+R +    K +E+ EK   +G+PI +YLHGN+ +R          +L   G+H L +DYRGF DS+G    E     DA   YN++K  + NS + +WGHSLG+G+++    KL  + +     G+ILE  F S     D +     TW +   PY        + N  L F + +NL++  + I+ILH+EDD ++   + +++Y     A   D   K    + KYG  H+ +   P LP+I+REF
Sbjct:   40 IGLVSLLILGATIPFLLHVFSDIDDLSRPSDLGLNHTINFYLKTEE---------------------GVRVGVWHT---VPEHRWKEAQGKNVEWYEKALGDGSPIFMYLHGNTGNR---------QILSALGYHALVMDYRGFGDSTGEP-TEPGLTTDALYLYNWIKKRSGNSLLCVWGHSLGSGVTTNTAVKL--LEQGKKFDGIILEGAFLSGRMAADQVFEHPFTWYYWKFPYIQYFLFNPMKNNNLDFPTDKNLEKIRSPIMILHSEDDHIVPMSVAQEIYRIAKKAQNSDERVKLVPFDGKYGYLHNGLYRDPALPNIVREF 332
[Close]
BLAST of Hydrolase_4 domain-containing protein vs. Ensembl Xenopus
Match: abhd12 (abhydrolase domain containing 12 [Source:NCBI gene;Acc:100216158])

HSP 1 Score: 185.267 bits (469), Expect = 1.339e-53
Identity = 112/325 (34.46%), Postives = 180/325 (55.38%), Query Frame = 2 
Query:   71 LQVIGLFTVLIYVIIPFILYIFPHIFSKIIFLDFV-YNIFTKLDKPEXXXXXXXXXXXXKIVNEYSNCELGAWEILSKVDENRKESCSLKQIEFAEKFSNGNPIILYLHGNSMHRGSNHRLLLYHVLRESGFHILTIDYRGFADSSGSIHNEDEALEDAFVAYNYLKLTAPNSSIFLWGHSLGTGISSLLLQKLSKMNECSAISGVILESPFTSILETMDHIGLTWPWRFMPYFDRIFKKALLNQKLAFNSIENLKETNNIILILHAEDDKVLSFKMGKKLYSTLLSAGK----DVYFKGFSSNLKYGHDYIVNCPELPDIIREF 1030
            L++  +F + +Y+ IPF++ I P I ++++FL+ V +  F  L +PE+   N       +   + S   +G W  +  V     +   L+  E  E  S   P+ILYLHGN+  RG +HR+ LY VL   G+H+++ DYRG+ DS GS  +E     DA   ++++K  + ++ +++WGHSLGTG+++ L+++L +    +    +ILESPFT+I E       +  +R+ P FD  F   +    + F + +N+K  +  +LILHAEDD V+ F +GKKLY+    A       V F  F  +L Y H YI   PEL  I+R+F
Sbjct:  114 LRMFLIFLLGLYIAIPFLVKICPAIQTQLVFLNLVRFPYFIDLKRPEDQGLNHTCNFYLQPEEDVS---IGVWHTVPAVLWKDAQGKDLEWYE--EVLSTSYPVILYLHGNAGTRGGDHRVQLYKVLSSMGYHVISFDYRGWGDSVGS-PSESGMTYDALHVFDWIKARSGDNPVYIWGHSLGTGVATNLVRRLCERE--TPPDSLILESPFTNIREEAKSHPFSVIYRYFPGFDWFFLDPITASGIKFANDDNVKYISCPLLILHAEDDPVIPFHLGKKLYNIAAPARSLRDYKVQFVPFHKDLGYRHKYIYRSPELRQILRDF 430
[Close]
BLAST of Hydrolase_4 domain-containing protein vs. Ensembl Xenopus
Match: ENSXETT00000040869.1 (loc683510 [Source:Xenbase;Acc:XB-GENE-920177])

HSP 1 Score: 167.933 bits (424), Expect = 8.949e-48
Identity = 113/333 (33.93%), Postives = 175/333 (52.55%), Query Frame = 2 
Query:   62 YLILQVIGLFTVLIYVIIPFILYIFPHIFSKIIFLDFVYNIFT-KLDKPEXXXXXXXXXXXXKIVNEYSN--------CELGAWEIL--SKVDENRKESCSLKQIEFAEKFSNGNPIILYLHGNSMHRGSNHRLLLYHVLRESGFHILTIDYRGFADSSGSIHNEDEALEDAFVAYNYLKLTAPNSSIFLWGHSLGTGISSLLLQKLSKMNECSAISGVILESPFTSILETMDHIGLTWPWRFMPYFDRIFKKALLNQKLAFNSIENLKETNNIILILHAEDDKVLSFKMGKKLYSTLLSA--GKDVYFKGFSSNLKYGHDYIVNCPELPDII 1021
            YL   V+ L    IY+ +PFI+ +FP + +K+++L+ +   F+  L  P+             I+N  +N          +G W  L  S+ +E + +     Q  + E  S+ NP+I+YLHGN   R  +HR+ L  VL  +GFH+L++DYRG+ADS+G    E+    D+   Y ++K  +  + + +WGHSLG+G+++   +KL +M   SA   VILESP+T+I E   +      +   P F+  F        + F S EN+K     ILILHAEDD V+   M KKL+   L +   KDV    F ++L Y H+ I   P+L +II
Sbjct:   52 YLKTSVVVLLC--IYISVPFIIRLFPALLAKVVYLNILKVPFSVDLRNPKL------------ILNHTTNFYLTTEDGVTVGVWHTLPVSRWEEAKHKD----QAWYEEALSDVNPVIIYLHGNGGTRAVDHRVQLVKVLSAAGFHVLSLDYRGYADSTGE-PTENGITTDSVYLYEWVKARSRGTPVCIWGHSLGSGVATNAARKLQEMG--SAADVVILESPYTNIREAGAYHPFGSIYHNFPGFEYFFLDTFTLNNIVFPSDENVKLLTTPILILHAEDDTVVPSFMAKKLHDIALKSQNSKDVKLVLFRADLGYQHENIYKDPKLSEII 363
[Close]
BLAST of Hydrolase_4 domain-containing protein vs. Ensembl Xenopus
Match: abhd12 (abhydrolase domain containing 12 [Source:NCBI gene;Acc:100216158])

HSP 1 Score: 158.303 bits (399), Expect = 7.125e-45
Identity = 104/318 (32.70%), Postives = 168/318 (52.83%), Query Frame = 2 
Query:   86 LFTVLIYVIIPFILYIFPHIFSKIIFLDFV-YNIFTKLDKPEXXXXXXXXXXXXKIVNEYSNCELGAWEILSKVDENRKESCSLKQIEFAEKFSNGNPIILYLHGNSMHRGSNHRLLLYHVLRESGFHILTIDYRGFADSSGSIHNEDEALEDAFVAYNYLKLTAPNSSIFLWGHSLGTGISSLLLQKLSKMNECSAISGVILESPFTSILETMDHIGLTWPWRFMPYFDRIFKKALLNQKLAFNSIENLKETNNIILILHAEDDKVLSFKMGKKLYSTLLSAGK----DVYFKGFSSNLKYGHDYIVNCPELPDIIR 1024
            +F + +Y+ IPF++ I P I ++++FL+ V +  F  L +PE+   N       +   + S   +G W  +  V     +   L+  E  E  S   P+ILYLHGN+   G+          R  G+H+++ DYRG+ DS GS  +E     DA   ++++K  + ++ +++WGHSLGTG+++ L+++L +    +    +ILESPFT+I E       +  +R+ P FD  F   +    + F + +N+K  +  +LILHAEDD V+ F +GKKLY+    A       V F  F  +L Y H YI   PEL  I+R
Sbjct:    4 IFLLGLYIAIPFLVKICPAIQTQLVFLNLVRFPYFIDLKRPEDQGLNHTCNFYLQPEEDVS---IGVWHTVPAVLWKDAQGKDLEWYE--EVLSTSYPVILYLHGNA---GT----------RSMGYHVISFDYRGWGDSVGS-PSESGMTYDALHVFDWIKARSGDNPVYIWGHSLGTGVATNLVRRLCERE--TPPDSLILESPFTNIREEAKSHPFSVIYRYFPGFDWFFLDPITASGIKFANDDNVKYISCPLLILHAEDDPVIPFHLGKKLYNIAAPARSLRDYKVQFVPFHKDLGYRHKYIYRSPELRQILR 300
[Close]
BLAST of Hydrolase_4 domain-containing protein vs. Ensembl Xenopus
Match: abhd12 (abhydrolase domain containing 12 [Source:NCBI gene;Acc:100216158])

HSP 1 Score: 158.688 bits (400), Expect = 7.526e-45
Identity = 104/323 (32.20%), Postives = 169/323 (52.32%), Query Frame = 2 
Query:   71 LQVIGLFTVLIYVIIPFILYIFPHIFSKIIFLDFV-YNIFTKLDKPEXXXXXXXXXXXXKIVNEYSNCELGAWEILSKVDENRKESCSLKQIEFAEKFSNGNPIILYLHGNSMHRGSNHRLLLYHVLRESGFHILTIDYRGFADSSGSIHNEDEALEDAFVAYNYLKLTAPNSSIFLWGHSLGTGISSLLLQKLSKMNECSAISGVILESPFTSILETMDHIGLTWPWRFMPYFDRIFKKALLNQKLAFNSIENLKETNNIILILHAEDDKVLSFKMGKKLYSTLLSAGK----DVYFKGFSSNLKYGHDYIVNCPELPDIIR 1024
            L++  +F + +Y+ IPF++ I P I ++++FL+ V +  F  L +PE+   N       +   + S   +G W  +  V     +   L+  E  E  S   P+ILYLHGN+               R  G+H+++ DYRG+ DS GS  +E     DA   ++++K  + ++ +++WGHSLGTG+++ L+++L +    +    +ILESPFT+I E       +  +R+ P FD  F   +    + F + +N+K  +  +LILHAEDD V+ F +GKKLY+    A       V F  F  +L Y H YI   PEL  I+R
Sbjct:   17 LRMFLIFLLGLYIAIPFLVKICPAIQTQLVFLNLVRFPYFIDLKRPEDQGLNHTCNFYLQPEEDVS---IGVWHTVPAVLWKDAQGKDLEWYE--EVLSTSYPVILYLHGNAG-------------TRSMGYHVISFDYRGWGDSVGS-PSESGMTYDALHVFDWIKARSGDNPVYIWGHSLGTGVATNLVRRLCERE--TPPDSLILESPFTNIREEAKSHPFSVIYRYFPGFDWFFLDPITASGIKFANDDNVKYISCPLLILHAEDDPVIPFHLGKKLYNIAAPARSLRDYKVQFVPFHKDLGYRHKYIYRSPELRQILR 318
[Close]
BLAST of Hydrolase_4 domain-containing protein vs. Ensembl Xenopus
Match: abhd12 (abhydrolase domain containing 12 [Source:NCBI gene;Acc:100216158])

HSP 1 Score: 159.458 bits (402), Expect = 2.598e-44
Identity = 104/323 (32.20%), Postives = 169/323 (52.32%), Query Frame = 2 
Query:   71 LQVIGLFTVLIYVIIPFILYIFPHIFSKIIFLDFV-YNIFTKLDKPEXXXXXXXXXXXXKIVNEYSNCELGAWEILSKVDENRKESCSLKQIEFAEKFSNGNPIILYLHGNSMHRGSNHRLLLYHVLRESGFHILTIDYRGFADSSGSIHNEDEALEDAFVAYNYLKLTAPNSSIFLWGHSLGTGISSLLLQKLSKMNECSAISGVILESPFTSILETMDHIGLTWPWRFMPYFDRIFKKALLNQKLAFNSIENLKETNNIILILHAEDDKVLSFKMGKKLYSTLLSAGK----DVYFKGFSSNLKYGHDYIVNCPELPDIIR 1024
            L++  +F + +Y+ IPF++ I P I ++++FL+ V +  F  L +PE+   N       +   + S   +G W  +  V     +   L+  E  E  S   P+ILYLHGN+               R  G+H+++ DYRG+ DS GS  +E     DA   ++++K  + ++ +++WGHSLGTG+++ L+++L +    +    +ILESPFT+I E       +  +R+ P FD  F   +    + F + +N+K  +  +LILHAEDD V+ F +GKKLY+    A       V F  F  +L Y H YI   PEL  I+R
Sbjct:   99 LRMFLIFLLGLYIAIPFLVKICPAIQTQLVFLNLVRFPYFIDLKRPEDQGLNHTCNFYLQPEEDVS---IGVWHTVPAVLWKDAQGKDLEWYE--EVLSTSYPVILYLHGNAG-------------TRSMGYHVISFDYRGWGDSVGSP-SESGMTYDALHVFDWIKARSGDNPVYIWGHSLGTGVATNLVRRLCERE--TPPDSLILESPFTNIREEAKSHPFSVIYRYFPGFDWFFLDPITASGIKFANDDNVKYISCPLLILHAEDDPVIPFHLGKKLYNIAAPARSLRDYKVQFVPFHKDLGYRHKYIYRSPELRQILR 400
[Close]
BLAST of Hydrolase_4 domain-containing protein vs. Ensembl Mouse
Match: Abhd12 (abhydrolase domain containing 12 [Source:MGI Symbol;Acc:MGI:1923442])

HSP 1 Score: 191.815 bits (486), Expect = 1.170e-56
Identity = 115/333 (34.53%), Postives = 188/333 (56.46%), Query Frame = 2 
Query:   59 IYLILQVIGLFTVLIYVIIPFILYIFPHIFSKIIFLDFVY-NIFTKLDKPEXXXXXXXXXXXXKIVNEYSNCELGAWEILSKVDENRKESCSLKQIEFAEKFSNGNPIILYLHGNSMHRGSNHRLLLYHVLRESGFHILTIDYRGFADSSGSIHNEDEALEDAFVAYNYLKLTAPNSSIFLWGHSLGTGISSLLLQKLSKMNECSAISGVILESPFTSILETMDHIGLTWPWRFMPYFDRIFKKALLNQKLAFNSIENLKETNNIILILHAEDDKVLSFKMGKKLYSTLLSAGK----DVYFKGFSSNLKYGHDYIVNCPELPDIIREFTTKA 1042
            ++  L+ I L  +  Y+ IPF++ + P I +K+IFL+FV    F  L KP++   N       +  ++ +   +G W  +  V    K +    Q+ + +  ++ + IILYLHGN+  RG +HR+ LY VL   G+H++T DYRG+ DS G+  +E     DA   ++++K  + ++ +++WGHSLGTG+++ L+++L +    +    +ILESPFT+I E       +  +R+ P FD  F   + +  + F + EN+K  +  +LILHAEDD V+ F +G+KLY+    +       V F  F S+L Y H YI   PELP I+REF  K+
Sbjct:   68 LWFRLRKILLCVLGFYIAIPFLVKLCPGIQAKLIFLNFVRVPYFIDLKKPQDQGLNHTCNYYLQPEDDVT---IGVWHTIPSV--WWKNAQGKDQMWYEDALASNHAIILYLHGNAGTRGGDHRVELYKVLSSLGYHVVTFDYRGWGDSVGTP-SERGMTYDALHVFDWIKARSGDNPVYIWGHSLGTGVATNLVRRLCERE--TPPDALILESPFTNIREEAKSHPFSVIYRYFPGFDWFFLDPITSSGIKFANDENMKHISCPLLILHAEDDPVVPFHLGRKLYNIAAPSRSFRDFKVQFIPFHSDLGYRHKYIYKSPELPRILREFLGKS 392
[Close]
BLAST of Hydrolase_4 domain-containing protein vs. Ensembl Mouse
Match: Abhd12b (abhydrolase domain containing 12B [Source:MGI Symbol;Acc:MGI:2685650])

HSP 1 Score: 144.05 bits (362), Expect = 6.107e-39
Identity = 100/317 (31.55%), Postives = 158/317 (49.84%), Query Frame = 2 
Query:  128 YIFPHIFSKIIFLDFV-YNIFTKLDKPEXXXXXXXXXXXXKIVNEYSNCE----LGAWE-ILSKVDENRKESCSLKQIEFAEKFSNGNPIILYLHGNSMHRGSNHRLLLYHVLRESGFHILTIDYRGFADSSGSIHNEDEALEDAFVAYNYLKLTAPNSSIFLWGHSLGTGISSLLLQKLSKMNECSAISGVILESPFTSILETMDHIGLTWPWRFMPYFDRIFKKALLNQKLAFNSIENLKETNNIILILHAEDDKVLSFKMGKKLYSTLLSAGKD-------VYFKGFSSNLKYGHDYIVNCPELPDIIREFTTK 1039
            +IFP + + +I+L+ +   I   L +PE              VN +   E    LG W  + S   E  K  C   +  +    S+GNPII+YLHG+ ++R    R+ L  VL + GFH+L++DYRGF DS+     E+    D    Y + K  +  + + LWGHSLGTG+++   + L        +  +ILE+PFT+I     +  L   +  +P   R F  AL  +K+ F + EN+K  ++ +LILH EDD+ +  + GK+LY    SA ++       V+  GF       HDY+   P L   +R+F ++
Sbjct:   60 HIFPPLMNMLIYLNCITAPILVDLKRPETKIA--------HTVNFFLKPEPKVLLGIWHTVPSYRGEEAKGKC---RCWYEASLSDGNPIIIYLHGSGINRAFCGRIKLTQVLSDGGFHVLSVDYRGFGDST-GTTTEEGLTTDIICVYEWTKARSGRTPVCLWGHSLGTGVATNAARVLEAKG--CPVDAIILEAPFTNIWAATINFPLVKMYWKLPGCLRTFVDALKEEKIVFPNDENVKFLSSPLLILHGEDDRTVPLEFGKQLYEIARSAYRNKERVKMVVFPPGFH------HDYLFKSPMLLSTVRDFLSE 356
[Close]
BLAST of Hydrolase_4 domain-containing protein vs. Ensembl Mouse
Match: Abhd12b (abhydrolase domain containing 12B [Source:MGI Symbol;Acc:MGI:2685650])

HSP 1 Score: 137.887 bits (346), Expect = 2.110e-37
Identity = 84/251 (33.47%), Postives = 132/251 (52.59%), Query Frame = 2 
Query:  308 ENRKESCSLKQIEFAEKFSNGNPIILYLHGNSMHRGSNHRLLLYHVLRESGFHILTIDYRGFADSSGSIHNEDEALEDAFVAYNYLKLTAPNSSIFLWGHSLGTGISSLLLQKLSKMNECSAISGVILESPFTSILETMDHIGLTWPWRFMPYFDRIFKKALLNQKLAFNSIENLKETNNIILILHAEDDKVLSFKMGKKLYSTLLSAGKD-------VYFKGFSSNLKYGHDYIVNCPELPDIIREFTTK 1039
            E  K  C   +  +    S+GNPII+YLHG+ ++R    R+ L  VL + GFH+L++DYRGF DS+     E+    D    Y + K  +  + + LWGHSLGTG+++   + L        +  +ILE+PFT+I     +  L   +  +P   R F  AL  +K+ F + EN+K  ++ +LILH EDD+ +  + GK+LY    SA ++       V+  GF       HDY+   P L   +R+F ++
Sbjct:   41 EEAKGKC---RCWYEASLSDGNPIIIYLHGSGINRAFCGRIKLTQVLSDGGFHVLSVDYRGFGDST-GTTTEEGLTTDIICVYEWTKARSGRTPVCLWGHSLGTGVATNAARVLEAKG--CPVDAIILEAPFTNIWAATINFPLVKMYWKLPGCLRTFVDALKEEKIVFPNDENVKFLSSPLLILHGEDDRTVPLEFGKQLYEIARSAYRNKERVKMVVFPPGFH------HDYLFKSPMLLSTVRDFLSE 279
[Close]
BLAST of Hydrolase_4 domain-containing protein vs. Ensembl Mouse
Match: Abhd12 (abhydrolase domain containing 12 [Source:MGI Symbol;Acc:MGI:1923442])

HSP 1 Score: 126.716 bits (317), Expect = 4.039e-33
Identity = 74/221 (33.48%), Postives = 129/221 (58.37%), Query Frame = 2 
Query:   59 IYLILQVIGLFTVLIYVIIPFILYIFPHIFSKIIFLDFVY-NIFTKLDKPEXXXXXXXXXXXXKIVNEYSNCELGAWEILSKVDENRKESCSLKQIEFAEKFSNGNPIILYLHGNSMHRGSNHRLLLYHVLRESGFHILTIDYRGFADSSGSIHNEDEALEDAFVAYNYLKLTAPNSSIFLWGHSLGTGISSLLLQKLSKMNECSAISGVILESPFTSILE 718
            ++  L+ I L  +  Y+ IPF++ + P I +K+IFL+FV    F  L KP++   N       +  ++ +   +G W  +  V    K +    Q+ + +  ++ + IILYLHGN+  RG +HR+ LY VL   G+H++T DYRG+ DS G+  +E     DA   ++++K  + ++ +++WGHSLGTG+++ L+++L +    +    +ILESPFT+I E
Sbjct:   68 LWFRLRKILLCVLGFYIAIPFLVKLCPGIQAKLIFLNFVRVPYFIDLKKPQDQGLNHTCNYYLQPEDDVT---IGVWHTIPSV--WWKNAQGKDQMWYEDALASNHAIILYLHGNAGTRGGDHRVELYKVLSSLGYHVVTFDYRGWGDSVGTP-SERGMTYDALHVFDWIKARSGDNPVYIWGHSLGTGVATNLVRRLCERE--TPPDALILESPFTNIRE 280
[Close]
BLAST of Hydrolase_4 domain-containing protein vs. Ensembl Mouse
Match: Abhd17a (abhydrolase domain containing 17A [Source:MGI Symbol;Acc:MGI:106388])

HSP 1 Score: 55.4546 bits (132), Expect = 3.752e-8
Identity = 62/242 (25.62%), Postives = 107/242 (44.21%), Query Frame = 2 
Query:  257 EYSNCELGAWEI-LSKVDENRKESCSLKQIEFAEKFSNGNPIILYLHGNSMHRGSNHRLLLYHVLRESGFHILTIDYRGFADSSGSIHNEDEALEDAFVAYNYLKLT---APNSSIFLWGHSLGTGISSLLLQKLSKMNECSAISGVILESPFTSILETMDHIGLTWPWRFMPY-FDRIFKKALLNQKLAFNSIENLKETNNIILILHAEDDKVLSFKMGKKLYSTLLSAGKDVYFKGFSSN 967
            +Y   EL   E+ ++K     + +C   +     +++     +L+ HGN++  G      +    R  G +I + DY G+  SSG   +E     D   A+  L+     +P+ SI L+G S+GT    +    L+   EC+A   V+L SP TS +       + +P     Y FD            AF +IE + +  + +LI+H  +D+V+ F  G  LY     A + ++ +G   N
Sbjct:   77 QYGQRELDTIEVFVTKSARANRIACMYVRCVPGARYT-----VLFSHGNAVDLGQMCSFYVGLGTR-IGCNIFSYDYSGYGISSGR-PSEKNLYADIDAAWQALRTRYGISPD-SIILYGQSIGT----VPTVDLASRYECAA---VVLHSPLTSGMR------VAFPDTKKTYCFD------------AFPNIEKVSKITSPVLIIHGTEDEVIDFSHGLALYERCPKAVEPLWVEGAGHN 285
[Close]
BLAST of Hydrolase_4 domain-containing protein vs. UniProt/SwissProt
Match: sp|Q8N2K0|ABD12_HUMAN (Lysophosphatidylserine lipase ABHD12 OS=Homo sapiens OX=9606 GN=ABHD12 PE=1 SV=2)

HSP 1 Score: 200.675 bits (509), Expect = 3.207e-59
Identity = 122/334 (36.53%), Postives = 192/334 (57.49%), Query Frame = 2 
Query:   59 IYLILQVIGLFTVL-IYVIIPFILYIFPHIFSKIIFLDFVY-NIFTKLDKPEXXXXXXXXXXXXKIVNEYSNCELGAWEILSKVDENRKESCSLKQIEFAEKFSNGNPIILYLHGNSMHRGSNHRLLLYHVLRESGFHILTIDYRGFADSSGSIHNEDEALEDAFVAYNYLKLTAPNSSIFLWGHSLGTGISSLLLQKLSKMNECSAISGVILESPFTSILETMDHIGLTWPWRFMPYFDRIFKKALLNQKLAFNSIENLKETNNIILILHAEDDKVLSFKMGKKLYSTLLSAGK----DVYFKGFSSNLKYGHDYIVNCPELPDIIREFTTKA 1042
            ++L L+ I LF VL +Y+ IPF++ + P I +K+IFL+FV    F  L KP++   N         +    +  +G W  +  V    K +    Q+ + +  ++ +PIILYLHGN+  RG +HR+ LY VL   G+H++T DYRG+ DS G+  +E     DA   ++++K  + ++ +++WGHSLGTG+++ L+++L +    +    +ILESPFT+I E       +  +R+ P FD  F   + +  + F + EN+K  +  +LILHAEDD V+ F++G+KLYS    A       V F  F S+L Y H YI   PELP I+REF  K+
Sbjct:   68 VWLRLRKI-LFCVLGLYIAIPFLIKLCPGIQAKLIFLNFVRVPYFIDLKKPQDQGLNHTCNYY---LQPEEDVTIGVWHTVPAV--WWKNAQGKDQMWYEDALASSHPIILYLHGNAGTRGGDHRVELYKVLSSLGYHVVTFDYRGWGDSVGTP-SERGMTYDALHVFDWIKARSGDNPVYIWGHSLGTGVATNLVRRLCERE--TPPDALILESPFTNIREEAKSHPFSVIYRYFPGFDWFFLDPITSSGIKFANDENVKHISCPLLILHAEDDPVVPFQLGRKLYSIAAPARSFRDFKVQFVPFHSDLGYRHKYIYKSPELPRILREFLGKS 392
[Close]
BLAST of Hydrolase_4 domain-containing protein vs. UniProt/SwissProt
Match: sp|Q08DW9|ABD12_BOVIN (Lysophosphatidylserine lipase ABHD12 OS=Bos taurus OX=9913 GN=ABHD12 PE=2 SV=1)

HSP 1 Score: 198.749 bits (504), Expect = 2.122e-58
Identity = 117/329 (35.56%), Postives = 188/329 (57.14%), Query Frame = 2 
Query:   71 LQVIGLFTVLIYVIIPFILYIFPHIFSKIIFLDFVY-NIFTKLDKPEXXXXXXXXXXXXKIVNEYSNCELGAWEILSKVDENRKESCSLKQIEFAEKFSNGNPIILYLHGNSMHRGSNHRLLLYHVLRESGFHILTIDYRGFADSSGSIHNEDEALEDAFVAYNYLKLTAPNSSIFLWGHSLGTGISSLLLQKLSKMNECSAISGVILESPFTSILETMDHIGLTWPWRFMPYFDRIFKKALLNQKLAFNSIENLKETNNIILILHAEDDKVLSFKMGKKLYSTLLSAGK----DVYFKGFSSNLKYGHDYIVNCPELPDIIREFTTKA 1042
            L+ I  F + +YV IPF++ + P I +K+IFL+FV    F  L +P++   N         +    +  +G W  +  V    K +    Q+ + +  S+ +PIILYLHGN+  RG +HR+ LY VL   G+H++T DYRG+ DS G+  +E     DA   ++++K+ + ++ +++WGHSLGTG+++ L+++L +    +    +ILESPFT+I E       +  +R+ P FD  F   + +  + F + EN+K  +  +LILHAEDD V+ F++G+KLY+    +       V F  F S+L Y H YI   PELP I+REF  K+
Sbjct:   72 LRKILFFVLGLYVAIPFLIKLCPGIQAKLIFLNFVRVPYFIDLKRPQDQGLNHTCNYY---LQPEEDVTIGVWHTVPTV--WWKNAQGKDQMWYEDALSSSHPIILYLHGNAGTRGGDHRVELYKVLSSLGYHVVTFDYRGWGDSVGTP-SERGMTYDALHVFDWIKVRSGDNPVYIWGHSLGTGVATNLVRRLCERE--TPPDALILESPFTNIREEAKSHPFSVIYRYFPGFDWFFLDPITSSGIQFANDENVKHISCSLLILHAEDDPVVPFQLGRKLYNIAAPSRSFRDFKVQFIPFHSDLGYRHKYIYKSPELPRILREFLGKS 392
[Close]
BLAST of Hydrolase_4 domain-containing protein vs. UniProt/SwissProt
Match: sp|Q4R766|ABD12_MACFA (Lysophosphatidylserine lipase ABHD12 OS=Macaca fascicularis OX=9541 GN=ABHD12 PE=2 SV=1)

HSP 1 Score: 196.823 bits (499), Expect = 1.020e-57
Identity = 121/334 (36.23%), Postives = 191/334 (57.19%), Query Frame = 2 
Query:   59 IYLILQVIGLFTVL-IYVIIPFILYIFPHIFSKIIFLDFVY-NIFTKLDKPEXXXXXXXXXXXXKIVNEYSNCELGAWEILSKVDENRKESCSLKQIEFAEKFSNGNPIILYLHGNSMHRGSNHRLLLYHVLRESGFHILTIDYRGFADSSGSIHNEDEALEDAFVAYNYLKLTAPNSSIFLWGHSLGTGISSLLLQKLSKMNECSAISGVILESPFTSILETMDHIGLTWPWRFMPYFDRIFKKALLNQKLAFNSIENLKETNNIILILHAEDDKVLSFKMGKKLYSTLLSAGK----DVYFKGFSSNLKYGHDYIVNCPELPDIIREFTTKA 1042
            ++L L+ I LF VL +Y+ IPF++ + P I +K+IFL+FV    F  L KP++   N         +    +  +G W  +  V    K +    Q+ + +  ++ + IILYLHGN+  RG +HR+ LY VL   G+H++T DYRG+ DS G+  +E     DA   ++++K  + ++ +++WGHSLGTG+++ L+++L +    +    +ILESPFT+I E       +  +R+ P FD  F   + +  + F + EN+K  +  +LILHAEDD V+ F++G+KLYS    A       V F  F S+L Y H YI   PELP I+REF  K+
Sbjct:   68 LWLRLRKI-LFCVLGLYIAIPFLIKLCPGIQAKLIFLNFVRVPYFIDLKKPQDQGLNHTCNYY---LQPEEDVTIGVWHTVPAV--WWKNAQGKDQMWYEDALASSHAIILYLHGNAGTRGGDHRVELYKVLSSLGYHVVTFDYRGWGDSVGTP-SERGMTYDALHVFDWIKARSGDNPVYIWGHSLGTGVATNLVRRLCERE--TPPDALILESPFTNIREEAKSHPFSVIYRYFPGFDWFFLDPITSSGIKFANDENVKHISCPLLILHAEDDPVVPFQLGRKLYSIAAPARSFRDFKVQFVPFHSDLGYRHKYIYKSPELPRILREFLGKS 392
[Close]
BLAST of Hydrolase_4 domain-containing protein vs. UniProt/SwissProt
Match: sp|Q6AYT7|ABD12_RAT (Lysophosphatidylserine lipase ABHD12 OS=Rattus norvegicus OX=10116 GN=Abhd12 PE=2 SV=1)

HSP 1 Score: 195.282 bits (495), Expect = 3.960e-57
Identity = 116/333 (34.83%), Postives = 189/333 (56.76%), Query Frame = 2 
Query:   59 IYLILQVIGLFTVLIYVIIPFILYIFPHIFSKIIFLDFVY-NIFTKLDKPEXXXXXXXXXXXXKIVNEYSNCELGAWEILSKVDENRKESCSLKQIEFAEKFSNGNPIILYLHGNSMHRGSNHRLLLYHVLRESGFHILTIDYRGFADSSGSIHNEDEALEDAFVAYNYLKLTAPNSSIFLWGHSLGTGISSLLLQKLSKMNECSAISGVILESPFTSILETMDHIGLTWPWRFMPYFDRIFKKALLNQKLAFNSIENLKETNNIILILHAEDDKVLSFKMGKKLYSTLLSAGK----DVYFKGFSSNLKYGHDYIVNCPELPDIIREFTTKA 1042
            ++  L+ I L  +  Y+ IPF++ + P I +K+IFL+FV    F  L KP++   N       +  ++ +   +G W  +  V    K +    Q+ + +  ++ +PIILYLHGN+  RG +HR+ LY VL   G+H++T DYRG+ DS G+  +E     DA   ++++K  + ++ +++WGHSLGTG+++ L+++L +    +    +ILESPFT+I E       +  +R+ P FD  F   + +  + F + EN+K  +  +LILHAEDD V+ F +G+KLY+    +       V F  F S+L Y H YI   PELP I+REF  K+
Sbjct:   68 LWFRLRKILLCVLGFYIAIPFLVKLCPGIQAKLIFLNFVRVPYFIDLKKPQDQGLNHTCNYYLQPEDDVT---IGVWHTIPSV--WWKNAQGKDQMWYEDALASNHPIILYLHGNAGTRGGDHRVELYKVLSSLGYHVVTFDYRGWGDSVGTP-SERGMTYDALHVFDWIKARSGDNPVYIWGHSLGTGVATNLVRRLCERE--TPPDALILESPFTNIREEAKSHPFSVIYRYFPGFDWFFLDPITSSGIKFANDENMKHISCPLLILHAEDDPVVPFHLGRKLYNIAAPSRSFRDFKVQFIPFHSDLGYRHKYIYKSPELPRILREFLGKS 392
[Close]
BLAST of Hydrolase_4 domain-containing protein vs. UniProt/SwissProt
Match: sp|Q08C93|ABD12_DANRE (Lysophosphatidylserine lipase ABHD12 OS=Danio rerio OX=7955 GN=abhd12 PE=2 SV=1)

HSP 1 Score: 194.126 bits (492), Expect = 7.897e-57
Identity = 117/326 (35.89%), Postives = 180/326 (55.21%), Query Frame = 2 
Query:   71 LQVIGLFTVLIYVIIPFILYIFPHIFSKIIFLDFVY-NIFTKLDKPEXXXXXXXXXXXXKIVNEYSNCELGAWEILSKVDENRKESCSLKQIEFAEK-FSNGNPIILYLHGNSMHRGSNHRLLLYHVLRESGFHILTIDYRGFADSSGSIHNEDEALEDAFVAYNYLKLTAPNSSIFLWGHSLGTGISSLLLQKLSKMNECSAISGVILESPFTSILETMDHIGLTWPWRFMPYFDRIFKKALLNQKLAFNSIENLKETNNIILILHAEDDKVLSFKMGKKLYSTLLSA----GKDVYFKGFSSNLKYGHDYIVNCPELPDIIREF 1030
            L+ I ++ + IY+ IP I+ + P I +K++FL+FV    F  L +P++   N  +      +       +G W     V          K  E+ EK F + +P+ILYLHGN+  RG +HR+ LY VL   G+H++T DYRG+ DS GS  +E     DA   Y ++K       +++WGHSLGTG+++ L+++L   +  +    +ILESPFT+I E       +  +R++P FD  F  A+    + F S EN+   +  +LILHAEDD V+ F++GKKLY     +    G  V F  FSS+L Y H +I   P+LP+I+ +F
Sbjct:   58 LRRILIWLLGIYIAIPVIIKVCPSIQAKLVFLNFVRVPYFIDLKRPQDQGMNHTHNF---YLQPEEGINIGVWHT---VPAGMWREAQAKDAEWYEKSFQSSHPVILYLHGNAGTRGGDHRVQLYKVLSSLGYHVVTFDYRGWGDSEGSP-SERGMTSDALFLYQWIKQRIGPKPLYIWGHSLGTGVATNLVRRLC--DRGTPPDALILESPFTNIREEAKSHPFSMVYRYLPGFDWFFLDAISANDIRFASDENVNHISCPVLILHAEDDTVVPFQLGKKLYDLAAQSKSLNGHKVQFIPFSSSLGYRHKFIYKSPQLPNILSDF 374
[Close]
BLAST of Hydrolase_4 domain-containing protein vs. TrEMBL
Match: A0A3S1HTN8 (AB hydrolase-1 domain-containing protein OS=Elysia chlorotica OX=188477 GN=EGW08_006341 PE=4 SV=1)

HSP 1 Score: 212.616 bits (540), Expect = 1.201e-61
Identity = 120/331 (36.25%), Postives = 188/331 (56.80%), Query Frame = 2 
Query:   74 QVIGLFTVLIYVIIPFILYIFPHIFSKIIFLDFV-YNIFTKLDKPEXXXXXXXXXXXXKIVNEYSNCELGAWEILSKVDENRKESCSLKQIEFAEKFSNGNPIILYLHGNSMHRGSNHRLLLYHVLRESGFHILTIDYRGFADSSGSIHNEDEALEDAFVAYNYLKLTAPNSSIFLWGHSLGTGISSLLLQKLSKMNECSAISGVILESPFTSILETMDHIGLTWPWRFMPYFDRIFKKALLNQKLAFNSIENLKETNNIILILHAEDDKVLSFKMGKKLY----STLLSAGKDVYFKGFSSNLKYGHDYIVNCPELPDIIREFTTKAINT 1051
            ++  L   LIY+ IP  +   P I  +++F + + +  F  L  P +F           + ++     +GAW +L K     +    L    F ++  NG  + LYLHGNS  RGS+HR+ LY +L    FH++TIDYRG+ DSSG+  +E+  ++D++  Y +LK    ++ IFLWGHSLGTG+++ L + L   NE    +G++LESPF ++++   H   + P+R +P+FD IF K+L  Q + F S E++      I+ILHAEDD ++ F +G+KLY    +T  +  K+V F  F  +L YGH  I   PE+ DI+R+F  K  N+
Sbjct:   44 KITTLTLFLIYIGIPIFVRSNPWIMPRVVFANLLRWPPFVNLSSPADFGLVNARHFFLDVEDD---VRIGAWHVLPKSMHEERGLVPLDS--FEKELKNGKKVFLYLHGNSGTRGSHHRVQLYKLLASLDFHVITIDYRGYGDSSGTP-SEEGVVKDSYFIYKWLKQRIGDTKIFLWGHSLGTGVTTKLAKILC--NEGDHPAGIVLESPFNNMIDAATHHPFSLPFRMLPWFDWIFLKSLGEQGIYFKSDESILSVTPHIMILHAEDDLIVPFDLGQKLYLKAKATRTAYTKNVEFVAFKGDLGYGHKLIYQAPEMGDIVRQFIQKCENS 366
[Close]
BLAST of Hydrolase_4 domain-containing protein vs. TrEMBL
Match: A0A0V1AB74 (Monoacylglycerol lipase ABHD12 OS=Trichinella patagoniensis OX=990121 GN=abhd12 PE=4 SV=1)

HSP 1 Score: 207.608 bits (527), Expect = 3.688e-60
Identity = 114/323 (35.29%), Postives = 181/323 (56.04%), Query Frame = 2 
Query:   83 GLFTVLIYVIIPFILYIFPHIFSKIIFLDFVYNIFTKLDKPEXXXXXXXXXXXXKIVNEYSNCELGAWEILSKVDENRKESCSLKQIEFAEKFSNGN-PIILYLHGNSMHRGSNHRLLLYHVLRESGFHILTIDYRGFADSSGSIHNEDEALEDAFVAYNYLKLTAPNSSIFLWGHSLGTGISSLLLQKLSKMNECSAISGVILESPFTSILETMDHIGLTWPWRFMPYFDRIFKKALLNQKLAFNSIENLKETNNIILILHAEDDKVLSFKMGKKLYSTLLSAGKDVYFKGFSSNLKYGHDYIVNCPELPDIIREFTTKAIN 1048
            G F V +Y I+P +LY+FP+I   +IF+  V   FT    P  +   + +   +  +      +LG W +L K   +  ES  L + EF   F +   P++LY HGN+  R ++HR+ LY++  E  +H++T DYRGFADS+GS  +E+   +DA+  Y +++  +  +S+  WGHSLGT +++     L     C    G++LE+PF ++ + + +   T  +R+ P+F  IF   LL   + F S E++K     ILILHAEDD ++  ++ ++L+   LSA +D  FK FS   KYGH +IV  PELP I + F  K  +
Sbjct:   12 GSFLVFLYGIVPLLLYLFPNIELSLIFMSAVNWPFTNYSDPRAYGVKYDSRNFY--LTSSDGIKLGVWHMLPK---SLHESSVLNEKEFGTVFDDERYPVVLYFHGNTWSRCASHRIQLYNIFTELNYHVVTFDYRGFADSTGSA-SEEGMNKDAYTVYQWIRTHSNRTSVLFWGHSLGTAVATRFAADLCLSGNCPL--GLVLEAPFNNMFDAVKNHPFTSMYRWHPWFAEIFTYPLLKYNVHFKSDEHIKNVYCPILILHAEDDNIIPSQLARQLHEAALSADRDSTFKEFSRTKKYGHKFIVREPELPTITKNFVKKCTS 326
[Close]
BLAST of Hydrolase_4 domain-containing protein vs. TrEMBL
Match: A0A2C9LK55 (Hydrolase_4 domain-containing protein OS=Biomphalaria glabrata OX=6526 GN=106055449 PE=4 SV=1)

HSP 1 Score: 207.994 bits (528), Expect = 4.740e-60
Identity = 126/331 (38.07%), Postives = 189/331 (57.10%), Query Frame = 2 
Query:   59 IYLILQVIGLFTVLIYVIIPFILYIFPHIFSKIIFLDFV-YNIFTKLDKPEXXXXXXXXXXXXKIVNEYSNCELGAWEILSKVDENRKESCSLKQIEFAEKFSNGNPIILYLHGNSMHRGSNHRLLLYHVLRESGFHILTIDYRGFADSSGSIHNEDEALEDAFVAYNYLKLTAPNSSIFLWGHSLGTGISSLLLQKLSKMNECSAISGVILESPFTSILETMDHIGLTWPWRFMPYFDRIFKKALLNQKLAFNSIENLKETNNIILILHAEDDKVLSFKMGKKLYSTLL-SAGKD-VYFKGFSSNLKYGHDYIVNCPELPDIIREFTTKA 1042
            ++L  ++  +    IYV IP  +     I  +IIFL+ V +  FT L KP +F  N         +N     ++G W +L    ++  +S ++   +F ++ SNG  + LYLHGNS  RGS HR+ LY +L +  FH++ IDYRG+ DS+G    E+  + D++  Y +LK    +S IFLWGHSLGTG+++ L + L +  +  A  G++LE+PF +I +   H   + P+R +PYF+ +F   L    L FNS ENL      I+ILHAEDD ++ F +G+KLY+    S G D V F  F ++L YGH  I   P+LP +IREF  K+
Sbjct:   30 VWLCAKITFITLFFIYVAIPVFVKANQWIMPRIIFLNIVRWPPFTDLTKPHDFGLNNTRNFY---LNTQEGVKIGVWHVLPVSVQS--DSNNIPWDKFEDELSNGKMVFLYLHGNSGTRGSYHRVQLYKILAQLDFHVIAIDYRGYGDSTGHP-TENGVVFDSYTIYKWLKSRVGDSKIFLWGHSLGTGVTAKLAKLLCEEEDHPA--GIVLEAPFNNIRDAAFHHPFSAPYRSLPYFEYVFVDPLKEHGLFFNSEENLASVIPHIMILHAEDDLIVPFHLGEKLYAKAKESRGHDKVQFVSFEASLGYGHKLIYKAPQLPSLIREFVAKS 352
[Close]
BLAST of Hydrolase_4 domain-containing protein vs. TrEMBL
Match: A0A2C9LKK5 (Hydrolase_4 domain-containing protein OS=Biomphalaria glabrata OX=6526 GN=106055449 PE=4 SV=1)

HSP 1 Score: 207.608 bits (527), Expect = 1.162e-59
Identity = 126/331 (38.07%), Postives = 188/331 (56.80%), Query Frame = 2 
Query:   59 IYLILQVIGLFTVLIYVIIPFILYIFPHIFSKIIFLDFV-YNIFTKLDKPEXXXXXXXXXXXXKIVNEYSNCELGAWEILSKVDENRKESCSLKQIEFAEKFSNGNPIILYLHGNSMHRGSNHRLLLYHVLRESGFHILTIDYRGFADSSGSIHNEDEALEDAFVAYNYLKLTAPNSSIFLWGHSLGTGISSLLLQKLSKMNECSAISGVILESPFTSILETMDHIGLTWPWRFMPYFDRIFKKALLNQKLAFNSIENLKETNNIILILHAEDDKVLSFKMGKKLYSTLL-SAGKD-VYFKGFSSNLKYGHDYIVNCPELPDIIREFTTKA 1042
            ++L  ++  +    IYV IP  +     I  +IIFL+ V +  FT L KP +F  N         +N     ++G W +L      + +S ++   +F ++ SNG  + LYLHGNS  RGS HR+ LY +L +  FH++ IDYRG+ DS+G    E+  + D++  Y +LK    +S IFLWGHSLGTG+++ L + L +  +  A  G++LE+PF +I +   H   + P+R +PYF+ +F   L    L FNS ENL      I+ILHAEDD ++ F +G+KLY+    S G D V F  F ++L YGH  I   P+LP +IREF  K+
Sbjct:   54 VWLCAKITFITLFFIYVAIPVFVKANQWIMPRIIFLNIVRWPPFTDLTKPHDFGLNNTRNFY---LNTQEGVKIGVWHVLPV--SVQSDSNNIPWDKFEDELSNGKMVFLYLHGNSGTRGSYHRVQLYKILAQLDFHVIAIDYRGYGDSTGHP-TENGVVFDSYTIYKWLKSRVGDSKIFLWGHSLGTGVTAKLAKLLCEEEDHPA--GIVLEAPFNNIRDAAFHHPFSAPYRSLPYFEYVFVDPLKEHGLFFNSEENLASVIPHIMILHAEDDLIVPFHLGEKLYAKAKESRGHDKVQFVSFEASLGYGHKLIYKAPQLPSLIREFVAKS 376
[Close]
BLAST of Hydrolase_4 domain-containing protein vs. TrEMBL
Match: A0A0V0S838 (Monoacylglycerol lipase ABHD12 OS=Trichinella nelsoni OX=6336 GN=abhd12 PE=4 SV=1)

HSP 1 Score: 206.068 bits (523), Expect = 1.405e-59
Identity = 114/325 (35.08%), Postives = 181/325 (55.69%), Query Frame = 2 
Query:   77 VIGLFTVLIYVIIPFILYIFPHIFSKIIFLDFVYNIFTKLDKPEXXXXXXXXXXXXKIVNEYSNCELGAWEILSKVDENRKESCSLKQIEFAEKFSNGN-PIILYLHGNSMHRGSNHRLLLYHVLRESGFHILTIDYRGFADSSGSIHNEDEALEDAFVAYNYLKLTAPNSSIFLWGHSLGTGISSLLLQKLSKMNECSAISGVILESPFTSILETMDHIGLTWPWRFMPYFDRIFKKALLNQKLAFNSIENLKETNNIILILHAEDDKVLSFKMGKKLYSTLLSAGKDVYFKGFSSNLKYGHDYIVNCPELPDIIREFTTKAIN 1048
            + G F V +Y I+P +LY+FP+I   +IF+  V   FT    P  +   + +   +  +      +LG W +L K   +  ES  L + EF   F +   P++LY HGN+  R ++HR+ LY++  E  +H++T DYRGFADS+GS  +E+   +DA   Y +++  +  +S+  WGHSLGT +++     L     C    G++LE+PF ++ + + +   T  +R+ P+F  IF   LL   + F S E++K     ILILHAEDD ++  ++ ++L+   LSA +D  FK FS   KYGH +IV  PELP I + F  K  +
Sbjct:   10 LAGSFLVFLYGIVPLLLYLFPNIELSLIFMSAVNWPFTNYSDPRAYGVKYDSRNFY--LTSSDGIKLGVWHMLPK---SLHESSVLNEKEFGTVFDDERYPVVLYFHGNTWSRCASHRIQLYNIFTELNYHVVTFDYRGFADSTGSA-SEEGMNKDAHTVYQWIRTHSNRTSVLFWGHSLGTAVATRFAADLCLSGNCPL--GLVLEAPFNNMFDAVKNHPFTSMYRWHPWFAEIFTYPLLKYNVHFKSDEHIKNVYCPILILHAEDDNIIPSQLARQLHEAALSADRDSTFKEFSRTKKYGHKFIVREPELPTITKNFVKKCTS 326
[Close]
BLAST of Hydrolase_4 domain-containing protein vs. Ensembl Cavefish
Match: abhd12 (abhydrolase domain containing 12 [Source:NCBI gene;Acc:767657])

HSP 1 Score: 196.052 bits (497), Expect = 1.155e-57
Identity = 122/342 (35.67%), Postives = 184/342 (53.80%), Query Frame = 2 
Query:   20 TINTKLISPVLMMIYLILQVIGLFTVLIYVIIPFILYIFPHIFSKIIFLDFVY-NIFTKLDKPEXXXXXXXXXXXXKIVNEYSNCELGAWEILSKVDENRKESCSLKQIEFAEKFSNGNPIILYLHGNSMHRGSNHRLLLYHVLRESGFHILTIDYRGFADSSGSIHNEDEALEDAFVAYNYLKLTAPNSSIFLWGHSLGTGISSLLLQKLSKMNECSAISGVILESPFTSILETMDHIGLTWPWRFMPYFDRIFKKALLNQKLAFNSIENLKETNNIILILHAEDDKVLSFKMGKKLYSTLLSA----GKDVYFKGFSSNLKYGHDYIVNCPELPDIIREF 1030
            T+  KL    LM     L+ I L+ + IY+ IP I+ +FP I +K++FL+FV    F  L +P++   N         +       +G W  +  V    KE+       F +   +  P++LYLHGN+  RG +HR+ LY VL   G+H++T DYRG+ DS GS  +E    +DA   Y +LK      S+++WGHSLGTG+++ L+++L   +  +    VILESPFT+I E       +  +R++P FD  F  A+    + F S EN+   +  +LILHAEDD V+   +GKKLY+    +    G  V F  F S+L Y H +I   P+LP I+ +F
Sbjct:  129 TMGRKLRRTGLMWR---LRRIFLWVLGIYIAIPLIIKLFPAIQAKLVFLNFVRVPYFIDLKRPQDQGLNHTRNF---YLQPEEGVNIGVWHTVPAVLW--KEAQGKDGEWFEKSLQSTQPVMLYLHGNAGTRGGDHRVQLYKVLSSLGYHVVTFDYRGWGDSEGSP-SERGMTQDALHLYQWLKQRIGRKSLYIWGHSLGTGVATNLVRRLC--DRGTPPDAVILESPFTNIREEAKSHPFSMVYRYLPGFDWFFLDAITANDIRFASDENVNHISCPVLILHAEDDAVVPLHLGKKLYNIAAQSKSLNGHKVQFIPFPSSLGYRHKFIYRSPQLPHILSDF 459
[Close]
BLAST of Hydrolase_4 domain-containing protein vs. Ensembl Cavefish
Match: ENSAMXT00000041282.1 (monoacylglycerol lipase ABHD12-like [Source:NCBI gene;Acc:103035174])

HSP 1 Score: 156.762 bits (395), Expect = 6.052e-44
Identity = 105/325 (32.31%), Postives = 167/325 (51.38%), Query Frame = 2 
Query:   86 LFTVLIYVIIPFILYIFPHIFSKIIFLDFVYNIFTKLDKPEXXXXXXXXXXXXKIVNEYSNCE----LGAWEILSKVDENRKESCSLKQIEFAEK-FSNGNPIILYLHGNSMHRGSNHRLLLYHVLRESGFHILTIDYRGFADSSGSIHNEDEALEDAFVAYNYLKLTAPNSSIFLWGHSLGTGISSLLLQKLSKMNECSAISGVILESPFTSIL--ETMDHIGLTWPWRFMPYFDRIFKKALLNQKLAFNSIENLKETNNIILILHAEDDKVLSFKMGKKLYS---TLLSAGKDVYFKGFSSNLKYGHDYIVNCPELPDIIREF 1030
            L   ++YV    I  +FP     +++   +   F  L +P        +      VN Y + E    LG W     V E++ +    K +E+ EK   +G+P+ +YLHGN+ +R + HR+ + ++L   G+H + +DYRGF DS G    E     DA   YN++K    +S + +WGHSLGTG+++ L  KL +  +   + GVILE  F S+   E   H    + W+F PY    F+ ++ N KL+F S ENLK+    +LILH++DD ++ + + ++LYS   T + +   V    F  +  Y H+ +   P LP IIR F
Sbjct:   42 LVLCVLYVASRVIPRLFPAFVQHMVYSHAIL-WFVDLSRP-------ADLALNHTVNMYLSSEEGITLGVWHT---VPEHKWKEAQGKDLEWYEKSLGDGSPVFIYLHGNTNNRAAPHRIGVANILSSLGYHAVVMDYRGFGDSIGEP-TEPGLTTDALYLYNWVKARCKDSPLVIWGHSLGTGVATNLAVKLQE--QGKPVDGVILEGAFNSLRLPEGFPHAFTWYYWKF-PYIQFFFQDSMKNNKLSFPSAENLKKMTTPLLILHSKDDHLVPYWVAEELYSIAKTAMKSDDRVRLVLFDGSHGYLHNGLYRDPALPGIIRTF 351
[Close]
BLAST of Hydrolase_4 domain-containing protein vs. Ensembl Cavefish
Match: ENSAMXT00000021496.2 (monoacylglycerol lipase ABHD12-like [Source:NCBI gene;Acc:103035683])

HSP 1 Score: 145.206 bits (365), Expect = 1.396e-39
Identity = 97/325 (29.85%), Postives = 166/325 (51.08%), Query Frame = 2 
Query:  122 ILYIFPHIFSKIIFLDFVYNI--------FTKLDKPEXXXXXXXXXXXXKIVNEYSNCE----LGAWEILSKVDENRKESCSLKQIEFAEK-FSNGNPIILYLHGNSMHRGSNHRLLLYHVLRESGFHILTIDYRGFADSSGSIHNEDEALEDAFVAYNYLKLTAPNSSIFLWGHSLGTGISSLLLQKLSKMNECSAISGVILESPFTSILETMDHIGLTWPWRFMPYFDRIFKKALLNQKLAFNSIENLKETNNIILILHAEDDKVLSFKMGKKLYSTLLSA---GKDVYFKGFSSNLKYGHDYIVNCPELPDIIREFTTKAIN 1048
            +LY  P +  ++ F  FV ++        F  L +P        +      +N Y + E    LG W     V E++ +    K +E+ EK   +G+P+ +YLH N  +R + HR+ + ++L   G+H + +DYRGF DS+G    E+  + D+   Y+++K+ + +S + +WGHS+GT +++    KL +  + +   GV++E  FT  +        TW +   P++   F       K A ++ +NLK+    +LILH+EDD+V+ F M ++LYST  SA    + V    F  +L Y H+ +   P LP I+REF    I+
Sbjct:   46 VLYAAPRVIPRL-FPAFVQHMVYSHAILWFVDLSRP-------ADLALNHTINMYLSSEEGITLGVWHT---VPEHKWKEAQGKDLEWYEKSLGDGSPVFIYLHANMHNRAAPHRIGVANLLSSLGYHAVVMDYRGFGDSTGEP-TENGLITDSLYLYHWVKVRSKDSLVIIWGHSIGTLVATNTAVKLQE--QGNPADGVMIEGAFTDAINEKYGPPFTWFYLKFPWY--FFSAPPKESKRAESNADNLKKMRTPLLILHSEDDQVVPFTMAQELYSTAKSAPNLKEQVKLISFDGSLGYRHNGLYRDPALPGILREFVQSLIS 354
[Close]
BLAST of Hydrolase_4 domain-containing protein vs. Ensembl Cavefish
Match: ENSAMXT00000031554.1 (monoacylglycerol lipase ABHD12-like [Source:NCBI gene;Acc:103035683])

HSP 1 Score: 144.436 bits (363), Expect = 3.101e-39
Identity = 96/319 (30.09%), Postives = 164/319 (51.41%), Query Frame = 2 
Query:  122 ILYIFPHIFSKIIFLDFVYNI--------FTKLDKPEXXXXXXXXXXXXKIVNEYSNCE----LGAWEILSKVDENRKESCSLKQIEFAEK-FSNGNPIILYLHGNSMHRGSNHRLLLYHVLRESGFHILTIDYRGFADSSGSIHNEDEALEDAFVAYNYLKLTAPNSSIFLWGHSLGTGISSLLLQKLSKMNECSAISGVILESPFTSILETMDHIGLTWPWRFMPYFDRIFKKALLNQKLAFNSIENLKETNNIILILHAEDDKVLSFKMGKKLYSTLLSA---GKDVYFKGFSSNLKYGHDYIVNCPELPDIIREF 1030
            +LY  P +  ++ F  FV ++        F  L +P        +      +N Y + E    LG W     V E++ +    K +E+ EK   +G+P+ +YLH N  +R + HR+ + ++L   G+H + +DYRGF DS+G    E+  + D+   Y+++K+ + +S + +WGHS+GT +++    KL +  + +   GV++E  FT  +        TW +   P++   F       K A ++ +NLK+    +LILH+EDD+V+ F M ++LYST  SA    + V    F  +L Y H+ +   P LP I+REF
Sbjct:   46 VLYAAPRVIPRL-FPAFVQHMVYSHAILWFVDLSRP-------ADLALNHTINMYLSSEEGITLGVWHT---VPEHKWKEAQGKDLEWYEKSLGDGSPVFIYLHANMHNRAAPHRIGVANLLSSLGYHAVVMDYRGFGDSTGEP-TENGLITDSLYLYHWVKVRSKDSLVIIWGHSIGTLVATNTAVKLQE--QGNPADGVMIEGAFTDAINEKYGPPFTWFYLKFPWY--FFSAPPKESKRAESNADNLKKMRTPLLILHSEDDQVVPFTMAQELYSTAKSAPNLKEQVKLISFDGSLGYRHNGLYRDPALPGILREF 348
[Close]
BLAST of Hydrolase_4 domain-containing protein vs. Ensembl Sea Lamprey
Match: ENSPMAT00000005892.1 (pep scaffold:Pmarinus_7.0:GL476342:292888:300705:-1 gene:ENSPMAG00000005303.1 transcript:ENSPMAT00000005892.1 gene_biotype:protein_coding transcript_biotype:protein_coding)

HSP 1 Score: 198.749 bits (504), Expect = 4.135e-61
Identity = 116/315 (36.83%), Postives = 174/315 (55.24%), Query Frame = 2 
Query:   95 VLIYVIIPFILYIFPHIFSKIIFLDFV-YNIFTKLDKPEXXXXXXXXXXXXKIVNEYSNCE----LGAWEILSKVDENRKESCSLKQIEFAEKFSNGNPIILYLHGNSMHRGSNHRLLLYHVLRESGFHILTIDYRGFADSSGSIHNEDEALEDAFVAYNYLKLTAPNSSIFLWGHSLGTGISSLLLQKLSKMNECSAISGVILESPFTSILETMDHIGLTWPWRFMPYFDRIFKKALLNQKLAFNSIENLKETNNIILILHAEDDKVLSFKMGKKLYSTLLSAGKDVYFKGFSSNLKYGHDYIVNCPELPDIIR 1024
            ++IYV +P ++ + P I +KI+FL+F+    F +L  P        +       N+Y   E    LG W  +       KE+    Q  +     NG P+ +Y HGN+  RG +HR+ LY VL  SGFH++T+DYRG+ DS+G+   E+    DA   Y + +  A    +++WGHSLGTG+++ + +KL +  + +    VILE+PFT+I E  D   L   ++  P FD  F  ++ +  + F S EN  E N  +LILHAEDD ++ F +GKKLY    SA  +V F  F++NL Y H Y+ + P LP IIR
Sbjct:   12 LVIYVAVPILVKVCPTIQAKIVFLNFIRVPFFIELHDP-------LSLGLNHTTNQYLTPEPGVRLGVWHTVPA--SQWKEAEGKDQQWYDAALGNGAPVFVYFHGNAGTRGGHHRVELYKVLSASGFHVVTLDYRGWGDSTGT-PTEEGITADAIFVYKWAQQRA-AGPVYIWGHSLGTGVATNVGRKLCE--QGAPPGAVILEAPFTNIREEADSHPLAQIYKIFPAFDWFFLDSITDSGVRFASDENASELNCPLLILHAEDDHIVPFHLGKKLYDIAASAKVNVEFVPFAANLGYRHKYVYSDPGLPLIIR 313
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BLAST of Hydrolase_4 domain-containing protein vs. Ensembl Sea Lamprey
Match: ENSPMAT00000005685.1 (pep scaffold:Pmarinus_7.0:GL490231:2586:6570:1 gene:ENSPMAG00000005151.1 transcript:ENSPMAT00000005685.1 gene_biotype:protein_coding transcript_biotype:protein_coding)

HSP 1 Score: 54.6842 bits (130), Expect = 1.275e-9
Identity = 39/123 (31.71%), Postives = 59/123 (47.97%), Query Frame = 2 
Query:   86 LFTVLIYVIIPFILYIFPHIFSKIIFLDFVYNIFT-KLDKPEXXXXXXXXXXXXKIVNEYSNCELGAWEIL--SKVDENRKESCSLKQIEFAEKFSNGNPIILYLHGNSMHRGSNHRLLLYHV 445
            LF +  YV++PFI+ +FP I  K++F +FV    T +L  PE           +  +   S   LG W  +  S   + R +        + +   +G PIILYLHGN+  R   +R+ LY V
Sbjct:   16 LFILGFYVLVPFIVKLFPTIAMKLVFNNFVRVPTTEQLLDPETHFGLNHTRNFY--IQPESGVTLGVWHTVPASLGQQARGKDSGW----YEDSLGSGRPIILYLHGNAASRAGAYRVQLYKV 132
[Close]
BLAST of Hydrolase_4 domain-containing protein vs. Ensembl Sea Lamprey
Match: abhd17b (abhydrolase domain containing 17B [Source:ZFIN;Acc:ZDB-GENE-040718-244])

HSP 1 Score: 46.9802 bits (110), Expect = 3.167e-6
Identity = 48/199 (24.12%), Postives = 86/199 (43.22%), Query Frame = 2 
Query:  380 ILYLHGNSMHRGSNHRLLLYHVLRES-GFHILTIDYRGFADSSG--SIHNEDEALEDAFVAYNYLKLTAPNSSIFLWGHSLGTGISSLLLQKLSKMNECSAISGVILESPFTSILETMDHIGLTWPWRFMPYFDRIFKKALLNQKLAFNSIENLKETNNIILILHAEDDKVLSFKMGKKLYSTLLSAGKDVYFKGFSSN 967
            +L+ HGN++  G       Y  L      ++ + DY G+  SSG  S  N    ++ AF A        P+  + L+G S+GT    +    L+   EC+   GV+L SP  S L  +   G+   + F P                F SIE + + ++ +L++H  +D+V+    G  +++      + ++ +G   N
Sbjct:  100 LLFSHGNAVDLG--QMCGFYADLAAKLNCNVFSYDYSGYGASSGKPSERNLYADIDAAFQALRTRYGLTPDK-VVLYGQSIGT----VPTVDLASRYECA---GVVLHSPLASGLRVL-FPGIARTYCFDP----------------FPSIEKISKVSSPVLVIHGTEDEVVDLSHGLAIHARCRRPAEPLWVEGAGHN 271
[Close]
BLAST of Hydrolase_4 domain-containing protein vs. Ensembl Nematostella
Match: EDO48697 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7RIF7])

HSP 1 Score: 140.584 bits (353), Expect = 3.344e-40
Identity = 71/184 (38.59%), Postives = 114/184 (61.96%), Query Frame = 2 
Query:  362 SNGNPIILYLHGNSMHRGSNHRLLLYHVLRESGFHILTIDYRGFADSSGSIHNEDEAL-EDAFVAYNYLKLTAPNSSIFLWGHSLGTGISSLLLQKLSKMNECSAISGVILESPFTSILET-MDHIGLTWPWRFMPYFDRIFKKALLNQKLAFNSIENLKETNNIILILHAEDDKVLSFKMGKK 907
             +G PI LYLHGN+ +R   HR+ LY VL +  FH++T DYRGFADS G  H  +E L ED    + ++K  +  + +++WGHSLG+G+++ + ++L++M   +   G+ILE+ F S+ +  +DH  L  P++F+PYF  +  ++    K  F + + L   N  +L+LH  DD ++ FK GKK
Sbjct:    2 GDGQPIFLYLHGNAFNRAEPHRVALYQVLSKLSFHVVTFDYRGFADSEG--HPSEEGLIEDGLTVWKWIKRRSKKAPVYIWGHSLGSGVATGVAERLTQMR--APPKGLILEAAFNSVYDAGLDH-SLAKPFKFLPYFHEVVMESF---KGVFETDKRLGNVNCPVLMLHDHDDDIIPFKYGKK 177
[Close]
BLAST of Hydrolase_4 domain-containing protein vs. Ensembl Nematostella
Match: EDO36646 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7SI15])

HSP 1 Score: 53.5286 bits (127), Expect = 5.956e-8
Identity = 55/202 (27.23%), Postives = 94/202 (46.53%), Query Frame = 2 
Query:  374 PIILYLHGNSMHRGSNHRLLLYHVLR-ESGFHILTIDYRGFADSSGSIHNEDEALEDAFVAYNYL--KLTAPNSSIFLWGHSLGTGISSLLLQKLSKMNECSAISGVILESPFTSILETMDHIGLTWPWRFMPYFDRIFKKALLNQKLAFNSIENLKETNNIILILHAEDDKVLSFKMGKKLYSTLLSAGKDV-YFKGFSSN 967
            P +L+ HGN+ + G  HRL+    L  + G ++L ++YRG+  S GS       L DA  + ++L  +     + I ++G SLG  ++  L+   + +    A+   ++E+ F SI    +   L      +PYF   F+         FNS+  +       L L    D+++  KM K LY +  S+ K +  F+G S N
Sbjct:   88 PTVLFFHGNAGNVG--HRLMNAKALHSQCGCNVLLVEYRGYGKSEGSPSEHGFQL-DAQASMDHLLSRTDIDPTQIIVFGRSLGGAVAIDLVSHPAYVQRAFAL---VVENTFVSIPAMANT--LIAGLHRLPYF--CFRN-------KFNSLSKIPNARVPTLFLSGMADQLIPPKMMKMLYQSSGSSLKKLEQFEGGSHN 272
[Close]
BLAST of Hydrolase_4 domain-containing protein vs. Ensembl Nematostella
Match: EDO45743 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7RS48])

HSP 1 Score: 50.447 bits (119), Expect = 4.456e-7
Identity = 55/205 (26.83%), Postives = 88/205 (42.93%), Query Frame = 2 
Query:  365 NGNPIILYLHGNSMHRGSNHRLLLYHVLRESGFHILTIDYRGFADSSGSIHNEDEALEDAFVAYNYLKLT---APNSSIFLWGHSLGTGISSLLLQKLSKMNECSAISGVILESPFTSILE-TMDHIGLTWPWRFMPYFDRIFKKALLNQKLAFNSIENLKETNNIILILHAEDDKVLSFKMGKKLYSTLLSAGKDVYFKGFSSN 967
            N    +L+ HGN++  G      +    R +  +I + DY G+  S+G   +E     D   A+N L+     +P + I L+G S+GT    +    L+   EC    GVIL SP TS +         TW       FD            AF SIE + +  + +L++H  +D+V+ F  G  +Y     A   ++ +G   N
Sbjct:   88 NARFTLLFSHGNAVDLGQMSSFYVGLGTRIN-CNIFSYDYSGYGVSTGK-PSEKNLYSDIDAAWNALRTRYGISPEN-IVLYGQSIGT----VPTIDLASRFECG---GVILHSPLTSGMRVAFPETKRTW------CFD------------AFPSIEKVSKIVSPVLVVHGTEDEVIDFSHGLAIYERCPRAVDPLWVEGAGHN 264
[Close]
BLAST of Hydrolase_4 domain-containing protein vs. Ensembl Medaka
Match: abhd12 (abhydrolase domain containing 12 [Source:NCBI gene;Acc:101170699])

HSP 1 Score: 195.667 bits (496), Expect = 1.547e-58
Identity = 120/326 (36.81%), Postives = 182/326 (55.83%), Query Frame = 2 
Query:   71 LQVIGLFTVLIYVIIPFILYIFPHIFSKIIFLDFVY-NIFTKLDKPEXXXXXXXXXXXXKIVNEYSNCELGAWEILSKVDENRKESCSLKQIEFAEKFSNGNPIILYLHGNSMHRGSNHRLLLYHVLRESGFHILTIDYRGFADSSGSIHNEDEALEDAFVAYNYLKLT-APNSSIFLWGHSLGTGISSLLLQKLSKMNECSAISGVILESPFTSILETMDHIGLTWPWRFMPYFDRIFKKALLNQKLAFNSIENLKETNNIILILHAEDDKVLSFKMGKKLYSTLLSA----GKDVYFKGFSSNLKYGHDYIVNCPELPDIIREF 1030
            ++ I L  ++IYV IP I+ IFP I +K++FL+FV    F  L +P++   N  +      +   S  + G W  +    +  +E+       +   FS+ NP+ILYLHGN+  RG +HR+ LY VL   G+H++T DYRG+ DS GS  +E     DA   Y++LK        +++WGHSLGTG+++ L+++L   +  +    +ILESPFT+I E       +  +R++P FD  F  A+    + F S EN+   +  +LILHAEDD V+ F +GKKLYS    +    G  V F  F ++L Y H +I   PELP I+ +F
Sbjct:   49 IKRIFLVLMIIYVSIPCIVKIFPSIQAKLVFLNFVRVPFFIDLKRPQDHGLNHTHNFY---LEPESGLKAGVWHTVPA--QMWREAQGKDGNWYLSTFSSSNPVILYLHGNAGTRGGDHRVQLYKVLSSLGYHVVTFDYRGWGDSEGSP-SEGGMTSDALFVYDWLKQQIGKTKPLYIWGHSLGTGVATNLVRRLC--DRGNPPDALILESPFTNIREEAKCHPFSMVYRYLPGFDWFFLDAITANNIRFASDENVNHISCPMLILHAEDDTVVPFYLGKKLYSMASRSQSLTGHKVQFVPFPASLGYKHKFIYRSPELPSILSDF 366
[Close]
BLAST of Hydrolase_4 domain-containing protein vs. Ensembl Medaka
Match: ENSORLT00000035678.1 (abhydrolase domain containing 12B [Source:NCBI gene;Acc:101159055])

HSP 1 Score: 163.31 bits (412), Expect = 1.021e-46
Identity = 100/320 (31.25%), Postives = 165/320 (51.56%), Query Frame = 2 
Query:  101 IYVIIPFILYIFPHIFSKIIFLDFV-YNIFTKLDKPEXXXXXXXXXXXXKIVNEYSNCELGAW-EILSKVDENRKESCSLKQIE-FAEKFSNGNPIILYLHGNSMHRGSNHRLLLYHVLRESGFHILTIDYRGFADSSGSIHNEDEAL-EDAFVAYNYLKLTAPNSSIFLWGHSLGTGISSLLLQKLSKMNECSAISGVILESPFTSILETMDHIGLTWPWRFMPYFDRIFKKALLNQKLAFNSIENLKETNNIILILHAEDDKVLSFKMGKKLYSTLLSAGKD------VYFKGFSSNLKYGHDYIVNCPELPDIIREF 1030
            +Y  +P  LY+FP + S  +F   +    F  L +P++              N Y N E   W  +   +  ++ E+ S +  + + E   +G P+I+YLHGN   R   HR+ L  +L  +GFH+L++DYRGF DSSG  H  +  L  DA     + K  +  S + LWGHSLG+G+++    +L +    +A+  +ILE+P+T I +   ++ LT  + F+P         L   ++ F + +NLK     +LILHAEDD V+  +MG++LY   L A ++      V    + ++L + H  I   P LP+I+++F
Sbjct:   11 VYASVPVFLYLFPWLLSHAVFAHLLRVPFFVDLSRPQDVLN--------HTCNFYLNTEEDVWVGVWHTLPASQWEAASGRSADWYQEALGDGQPVIIYLHGNVGTRALRHRVELVTLLSAAGFHVLSLDYRGFGDSSG--HPSEAGLTSDALYLQQWAKTRSGGSPVCLWGHSLGSGVATNAAVRLQEGE--AAVDALILEAPYTRIGDVAANLLLTKIYTFLPGLKDFLFDLLEKNQIEFANDKNLKTLTCPLLILHAEDDNVVPHRMGQQLYQVSLEAQREFGTDDRVAMVSYPADLGFSHSNIYMDPSLPEIVKKF 318
[Close]
BLAST of Hydrolase_4 domain-containing protein vs. Ensembl Medaka
Match: si:ch211-117n7.7 (monoacylglycerol lipase ABHD12 [Source:NCBI gene;Acc:101159289])

HSP 1 Score: 146.747 bits (369), Expect = 3.063e-40
Identity = 101/343 (29.45%), Postives = 168/343 (48.98%), Query Frame = 2 
Query:   35 LISPVLMMIYLILQVIGLFTVLIYVIIPFILYIFPHIFSKIIF-LDFVYNIFTKLDKPEXXXXXXXXXXXXKIVNEYSNCE----LGAWEILSKVDENRKESCSLKQIE-FAEKFSNGNPIILYLHGNSMHRGSNHRLLLYHVLRESGFHILTIDYRGFADSSGSIHNEDEALEDAFVAYNYLKLTAPNSSIFLWGHSLGTGISSLLLQKLSKMNECSAISGVILESPFTSILETMDHIGLTWPWRFMPYFDR---IFKKALLNQKLAFNSIENLKETNNIILILHAEDDKVLSFKMGKKLYSTLLSA--GKDVYFKGFSSNLKYGHDYIVNCPELPDIIREF 1030
            L+  V +  ++   ++  F V+I  +IP  L + P I  + ++        F  L +P +F+ N         +N Y   E    LG W     V  +R      K +  +     +G+P+ +Y HGN+  R + HR+ +  +L   G+H+L  DYRGF DS+G    E     DA   YN++K  + +S + +WGHSLGTG+++    KL  +++     GVILE  F S  + + +   TW +  +P  +    +F K L    + F S +NLK+  + IL LH+EDD ++  ++ ++ Y    +A     V    F  +L Y H+ +   P+LP II+EF
Sbjct:    8 LVESVRLQPWIKWGLLAAFVVVI--VIPVTLVVMPEILQQFVYKYRLRVPFFVDLSRPADFSLN-------HTINMYLTTEEGISLGVWH---TVPAHRLGEAQGKDLAWYQNSLRDGSPVFIYFHGNTGTRAAVHRVGVAKLLSALGYHVLVPDYRGFGDSTGE-PTESGLTTDATYLYNWVKARSGDSLVVIWGHSLGTGVTTNTAVKL--LDQGVVFDGVILEGAFNSQRQQIPYDPFTWYYCRLPSLESLCYLFAKPLAKDTIMFPSEQNLKKMKSPILFLHSEDDHLVPIEIARQTYEVAANAQSSNRVRLVTFDGSLGYLHNGLYRDPKLPGIIKEF 335
[Close]
BLAST of Hydrolase_4 domain-containing protein vs. Ensembl Medaka
Match: si:ch211-117n7.7 (monoacylglycerol lipase ABHD12 [Source:NCBI gene;Acc:101159289])

HSP 1 Score: 145.591 bits (366), Expect = 1.072e-39
Identity = 95/326 (29.14%), Postives = 158/326 (48.47%), Query Frame = 2 
Query:   86 LFTVLIYVIIPFILYIFPHIFSKIIF-LDFVYNIFTKLDKPEXXXXXXXXXXXXKIVNEYSNCE----LGAWEILSKVDENRKESCSLKQIE-FAEKFSNGNPIILYLHGNSMHRGSNHRLLLYHVLRESGFHILTIDYRGFADSSGSIHNEDEALEDAFVAYNYLKLTAPNSSIFLWGHSLGTGISSLLLQKLSKMNECSAISGVILESPFTSILETMDHIGLTWPWRFMPYFDR---IFKKALLNQKLAFNSIENLKETNNIILILHAEDDKVLSFKMGKKLYSTLLSA--GKDVYFKGFSSNLKYGHDYIVNCPELPDIIREF 1030
            L   ++ ++IP  L + P I  + ++        F  L +P        ++     +N Y   E    LG W     V  +R      K +  +     +G+P+ +Y HGN+  R + HR+ +  +L   G+H+L  DYRGF DS+G    E     DA   YN++K  + +S + +WGHSLGTG+++    KL  +++     GVILE  F S  + + +   TW +  +P  +    +F K L    + F S +NLK+  + IL LH+EDD ++  ++ ++ Y    +A     V    F  +L Y H+ +   P+LP II+EF
Sbjct:   39 LAAFVVVIVIPVTLVVMPEILQQFVYKYRLRVPFFVDLSRP-------ADFSLNHTINMYLTTEEGISLGVWHT---VPAHRLGEAQGKDLAWYQNSLRDGSPVFIYFHGNTGTRAAVHRVGVAKLLSALGYHVLVPDYRGFGDSTGE-PTESGLTTDATYLYNWVKARSGDSLVVIWGHSLGTGVTTNTAVKL--LDQGVVFDGVILEGAFNSQRQQIPYDPFTWYYCRLPSLESLCYLFAKPLAKDTIMFPSEQNLKKMKSPILFLHSEDDHLVPIEIARQTYEVAANAQSSNRVRLVTFDGSLGYLHNGLYRDPKLPGIIKEF 351
[Close]
BLAST of Hydrolase_4 domain-containing protein vs. Ensembl Medaka
Match: ENSORLT00000011241.2 (abhydrolase domain containing 12B [Source:NCBI gene;Acc:101159055])

HSP 1 Score: 121.709 bits (304), Expect = 3.991e-31
Identity = 90/317 (28.39%), Postives = 148/317 (46.69%), Query Frame = 2 
Query:  101 IYVIIPFILYIFPHIFSKIIFLDFV-YNIFTKLDKPEXXXXXXXXXXXXKIVNEYSNCELGAW-EILSKVDENRKESCSLKQIE-FAEKFSNGNPIILYLHGNSMHRGSNHRLLLY--HVLRESGFHILTIDYRGFADSSGSIHNEDEAL-EDAFVAYNYLKLTAPNSSIFLWGHSLGTGISSLLLQKLSKMNECSAISGVILESPFTSILETMDHIGLTWPWRFMPYFDRIFKKALLNQKLAFNSIENLKETNNIILILHAEDDKVLSFKMGKKL-YSTLLSAGKD--VYFKGFSSNLKYGHDYIVNCPELPDIIR 1024
            +Y  +P  LY+FP + S  +F   +    F  L +P++              N Y N E   W  +   +  ++ E+ S +  + + E   +G P+I+YLHGN   R     + L+   +L  +GFH+L++DYRGF DSSG  H  +  L  DA     + K  +  S + LWGHSLG+G+++    +L +       SG        +  E +  I     + F+P         L   ++ F + +NLK     +LILHAEDD V+  +MG+++        G D  V    + ++L + H  I   P LP+I++
Sbjct:   15 VYASVPVFLYLFPWLLSHAVFAHLLRVPFFVDLSRPQDVLN--------HTCNFYLNTEEDVWVGVWHTLPASQWEAASGRSADWYQEALGDGQPVIIYLHGNVGTR----SVFLWDPQLLSAAGFHVLSLDYRGFGDSSG--HPSEAGLTSDALYLQQWAKTRSGGSPVCLWGHSLGSGVATNAAVRLQEGGGALLPSGCHGNRKDKTTKEKLFGI-----YTFLPGLKDFLFDLLEKNQIEFANDKNLKTLTCPLLILHAEDDNVVPHRMGQQVSLEAQREFGTDDRVAMVSYPADLGFSHSNIYMDPSLPEIVK 312
[Close]
BLAST of Hydrolase_4 domain-containing protein vs. Planmine SMEST
Match: SMESG000015331.1 (SMESG000015331.1)

HSP 1 Score: 547.74 bits (1410), Expect = 0.000e+0
Identity = 267/267 (100.00%), Postives = 267/267 (100.00%), Query Frame = 2 
Query:  287 EILSKVDENRKESCSLKQIEFAEKFSNGNPIILYLHGNSMHRGSNHRLLLYHVLRESGFHILTIDYRGFADSSGSIHNEDEALEDAFVAYNYLKLTAPNSSIFLWGHSLGTGISSLLLQKLSKMNECSAISGVILESPFTSILETMDHIGLTWPWRFMPYFDRIFKKALLNQKLAFNSIENLKETNNIILILHAEDDKVLSFKMGKKLYSTLLSAGKDVYFKGFSSNLKYGHDYIVNCPELPDIIREFTTKAINTKKIGDTKHVNNI 1087
            EILSKVDENRKESCSLKQIEFAEKFSNGNPIILYLHGNSMHRGSNHRLLLYHVLRESGFHILTIDYRGFADSSGSIHNEDEALEDAFVAYNYLKLTAPNSSIFLWGHSLGTGISSLLLQKLSKMNECSAISGVILESPFTSILETMDHIGLTWPWRFMPYFDRIFKKALLNQKLAFNSIENLKETNNIILILHAEDDKVLSFKMGKKLYSTLLSAGKDVYFKGFSSNLKYGHDYIVNCPELPDIIREFTTKAINTKKIGDTKHVNNI
Sbjct:   38 EILSKVDENRKESCSLKQIEFAEKFSNGNPIILYLHGNSMHRGSNHRLLLYHVLRESGFHILTIDYRGFADSSGSIHNEDEALEDAFVAYNYLKLTAPNSSIFLWGHSLGTGISSLLLQKLSKMNECSAISGVILESPFTSILETMDHIGLTWPWRFMPYFDRIFKKALLNQKLAFNSIENLKETNNIILILHAEDDKVLSFKMGKKLYSTLLSAGKDVYFKGFSSNLKYGHDYIVNCPELPDIIREFTTKAINTKKIGDTKHVNNI 304
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BLAST of Hydrolase_4 domain-containing protein vs. Planmine SMEST
Match: SMESG000015331.1 (SMESG000015331.1)

HSP 1 Score: 547.354 bits (1409), Expect = 0.000e+0
Identity = 267/267 (100.00%), Postives = 267/267 (100.00%), Query Frame = 2 
Query:  287 EILSKVDENRKESCSLKQIEFAEKFSNGNPIILYLHGNSMHRGSNHRLLLYHVLRESGFHILTIDYRGFADSSGSIHNEDEALEDAFVAYNYLKLTAPNSSIFLWGHSLGTGISSLLLQKLSKMNECSAISGVILESPFTSILETMDHIGLTWPWRFMPYFDRIFKKALLNQKLAFNSIENLKETNNIILILHAEDDKVLSFKMGKKLYSTLLSAGKDVYFKGFSSNLKYGHDYIVNCPELPDIIREFTTKAINTKKIGDTKHVNNI 1087
            EILSKVDENRKESCSLKQIEFAEKFSNGNPIILYLHGNSMHRGSNHRLLLYHVLRESGFHILTIDYRGFADSSGSIHNEDEALEDAFVAYNYLKLTAPNSSIFLWGHSLGTGISSLLLQKLSKMNECSAISGVILESPFTSILETMDHIGLTWPWRFMPYFDRIFKKALLNQKLAFNSIENLKETNNIILILHAEDDKVLSFKMGKKLYSTLLSAGKDVYFKGFSSNLKYGHDYIVNCPELPDIIREFTTKAINTKKIGDTKHVNNI
Sbjct:    6 EILSKVDENRKESCSLKQIEFAEKFSNGNPIILYLHGNSMHRGSNHRLLLYHVLRESGFHILTIDYRGFADSSGSIHNEDEALEDAFVAYNYLKLTAPNSSIFLWGHSLGTGISSLLLQKLSKMNECSAISGVILESPFTSILETMDHIGLTWPWRFMPYFDRIFKKALLNQKLAFNSIENLKETNNIILILHAEDDKVLSFKMGKKLYSTLLSAGKDVYFKGFSSNLKYGHDYIVNCPELPDIIREFTTKAINTKKIGDTKHVNNI 272
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BLAST of Hydrolase_4 domain-containing protein vs. Planmine SMEST
Match: SMESG000046033.1 (SMESG000046033.1)

HSP 1 Score: 395.586 bits (1015), Expect = 3.216e-137
Identity = 197/327 (60.24%), Postives = 253/327 (77.37%), Query Frame = 2 
Query:   95 VLIYVIIPFILYIFPHIFSKIIFLDFVY-NIFTKLDKPEXXXXXXXXXXXXKIVNEYSNCELGAWEILSKVDE-NRKESCSLKQIEFAEKFSNGNPIILYLHGNSMHRGSNHRLLLYHVLRESGFHILTIDYRGFADSSGSIHNEDEALEDAFVAYNYLKLTAPNSSIFLWGHSLGTGISSLLLQKLSKMNECSAISGVILESPFTSILETMDHIGLTWPWRFMPYFDRIFKKALLNQKLAFNSIENLKETNNIILILHAEDDKVLSFKMGKKLYSTLLSAGKDVYFKGFSSNLKYGHDYIVNCPELPDIIREFTTKAINTKKIGDT 1069
            + IY++ P I+Y++P I +K I L+  +  +FT L KP+ F F   NWR  +I N YS CELGAWEI+ K DE N K+   L + EF + FSNG PII+Y HG +MHRGS+HR+ LYH+LR SG+HILT+DY+GF DSSGSI++E+E LEDAFV Y Y K  APNS +F+WGHSLGTGISSLLL+KLS ++ C++I G+ILESPFTSILETMDHI  TWPWR+MPYF+ IFK++L++QK+ F+SIENLK  N  I+ILHAEDD++L F+MG+KLYSTL S GK+V+FKGFSS   YGH +I+  PELP++IREFT  A+  K  G +
Sbjct:    3 ITIYILFPLIIYLYPWILAKCILLNTAFITVFTNLKKPDYFKFTKGNWRYLRIKNNYSKCELGAWEIICKEDEINNKDK--LNKEEFMKIFSNGRPIIIYFHGITMHRGSSHRVELYHMLRNSGYHILTVDYKGFGDSSGSINDEEELLEDAFVTYQYAKKVAPNSPLFVWGHSLGTGISSLLLKKLSNIDGCASIDGLILESPFTSILETMDHICFTWPWRYMPYFNCIFKQSLIDQKITFSSIENLKVVNVPIIILHAEDDRILKFEMGQKLYSTLKSEGKNVFFKGFSSKFGYGHKHIIRYPELPNLIREFTNGALTQKLSGHS 327
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BLAST of Hydrolase_4 domain-containing protein vs. Planmine SMEST
Match: SMESG000046035.1 (SMESG000046035.1)

HSP 1 Score: 219.55 bits (558), Expect = 3.461e-69
Identity = 113/273 (41.39%), Postives = 164/273 (60.07%), Query Frame = 2 
Query:  245 KIVNEYSNCELGAWEILSKVDENRKESCSLKQIEFAEKFSNGNPIILYLHGNSMHRGSNHRLLLYHVLRESGFHILTIDYRGFADSSGSIHNEDEALEDAFVAYNYLKLTAPNSSIFLWGHSLGTGISSLLLQKLSKMNECSAISGVILESPFTSILETMDHIGLTWPWRFMPYFDRIFKKALLNQKLAFNSIENLKETNNIILILHAEDDKVLSFKMGKKLYSTLLSAGKDVYFKGFSSNLKYGHDYIVNCPELPDIIREFTTKAINTKKIG 1063
            +I N   N ELGAW+I+  +D+       L + EF   F+N  PI+L +                      GFH+LTIDYRG+ DS G++ NE++ALED F+ + YL   APNSS+F+WGHSLGTGISS+ + KL+ +     +  ++LE+PFTSI + M++      WR M YF+ +F+++ +NQKL FNS +NL      ILI+HAEDD+V+S +MG++LYS++     D +FK FS  L+ GH  I     LP +I++FT  A+     G
Sbjct:    8 RIRNTNYNYELGAWQIIC-IDDETPGYVPLNKAEFETIFANNRPILLKI----------------------GFHVLTIDYRGYGDSPGTLQNENDALEDTFITFKYLMSIAPNSSVFVWGHSLGTGISSIFVNKLASLGLKYNVMALVLEAPFTSIPDFMNYTPYLGLWRIMFYFNLVFQQSAINQKLTFNSTKNLATFFAPILIMHAEDDQVISVEMGQQLYSSIFDIKTDTFFKRFSYLLQLGHSGITTYDNLPKLIKDFTAAALAQNFTG 257
[Close]
BLAST of Hydrolase_4 domain-containing protein vs. Planmine SMEST
Match: SMESG000018264.1 (SMESG000018264.1)

HSP 1 Score: 211.075 bits (536), Expect = 2.574e-65
Identity = 131/328 (39.94%), Postives = 182/328 (55.49%), Query Frame = 2 
Query:  122 ILYIFPHIFSKIIFLDFVYNIFT--------------KLDKPEXXXXXXXXXXXXKIVNEYSNCELGAWEILSKVDENRKESCSLKQIEFAEKFSNGNPIILYLHGNSMHRGSNHRLLLYHVLRESGFHILTIDYRGFADSSGSIHNEDEALEDAFVAYNYLKLTAPNSSIFLWGHSLGTGISSLLLQKLSKMNECSAISGVILESPFTSILETMDHIGLTWPWRFMPYFDRIFKKALLNQKLAFNSIENLKETNNIILILHAEDDKVLSFKMGKKLYSTLLSAGKDVYFKGFSSNLKYGHDYIVNCPELPDIIREFTTKAINTKKIG 1063
            I+Y+FP IF K++F   +    +               L  PENF FN +N+RNF+I N   N EL AW+I+ K DE       L + EF   F+N  PI+LY HGN   RG+ +R+  YH+LR++GFH+L +DYRGF +S G++  ED+ALEDAF+ + YL   APNSS+F+WGHSLGTGISSLL+ K          S + ++S    +  T   +                       KL FN+ +NL+     ILI+HAE+D V++F MG++LYS+L    KDV+FK FS  L +GH  I     LP +I++F   A      G
Sbjct:    2 IVYVFPSIFIKVVFQGLLIYFASLMHLCHLGSSKRTDYLKYPENFRFNMRNFRNFRIKNAEYNYELSAWQIICKDDET-PGYVPLNKTEFERIFANNRPILLYFHGNRGSRGAYYRVDFYHLLRKNGFHVLAVDYRGFGESDGTLETEDDALEDAFLTFRYLTKIAPNSSVFVWGHSLGTGISSLLVHK----------SSLYIDSRCPIVFSTFSVVAA--------------------HKLTFNNTKNLETFFAPILIMHAEEDNVVNFVMGQQLYSSLFDKKKDVFFKRFSYLLNFGHLRITRYYNLPKLIKDFANAAQKQNSTG 298
The following BLAST results are available for this feature:
BLAST of Hydrolase_4 domain-containing protein vs. Ensembl Human
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Human e!99)
Total hits: 5
Match NameE-valueIdentityDescription
ABHD126.679e-6036.53abhydrolase domain containing 12 [Source:HGNC Symb... [more]
ABHD129.364e-5836.28abhydrolase domain containing 12 [Source:HGNC Symb... [more]
ABHD122.577e-5239.41abhydrolase domain containing 12 [Source:HGNC Symb... [more]
ABHD122.409e-4338.50abhydrolase domain containing 12 [Source:HGNC Symb... [more]
ABHD12B1.307e-4133.21abhydrolase domain containing 12B [Source:HGNC Sym... [more]
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BLAST of Hydrolase_4 domain-containing protein vs. Ensembl Celegans
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99)
Total hits: 4
Match NameE-valueIdentityDescription
abhd-129.824e-4632.34ABHydrolase Domain containing homolog [Source:Uni... [more]
abhd-129.824e-4632.34ABHydrolase Domain containing homolog [Source:Uni... [more]
Y41E3.182.912e-724.48pep chromosome:WBcel235:IV:15061929:15065748:-1 ge... [more]
aho-37.449e-725.25Alpha/beta hydrolase domain-containing protein aho... [more]
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BLAST of Hydrolase_4 domain-containing protein vs. Ensembl Fly
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99)
Total hits: 2
Match NameE-valueIdentityDescription
CG151115.678e-4738.05gene:FBgn0034419 transcript:FBtr0086581[more]
CG151111.021e-4638.05gene:FBgn0034419 transcript:FBtr0086580[more]
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BLAST of Hydrolase_4 domain-containing protein vs. Ensembl Zebrafish
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99)
Total hits: 5
Match NameE-valueIdentityDescription
abhd121.046e-5735.89abhydrolase domain containing 12 [Source:NCBI gene... [more]
AL953905.14.572e-4637.31pep chromosome:GRCz11:CHR_ALT_CTG17_1_12:21174970:... [more]
si:ch211-117n7.75.627e-4030.70si:ch211-117n7.7 [Source:ZFIN;Acc:ZDB-GENE-060503-... [more]
si:ch211-117n7.61.072e-3532.95si:ch211-117n7.6 [Source:ZFIN;Acc:ZDB-GENE-060503-... [more]
si:ch211-117n7.71.359e-3530.09si:ch211-117n7.7 [Source:ZFIN;Acc:ZDB-GENE-060503-... [more]
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BLAST of Hydrolase_4 domain-containing protein vs. Ensembl Xenopus
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99)
Total hits: 5
Match NameE-valueIdentityDescription
abhd121.339e-5334.46abhydrolase domain containing 12 [Source:NCBI gene... [more]
ENSXETT00000040869.18.949e-4833.93loc683510 [Source:Xenbase;Acc:XB-GENE-920177][more]
abhd127.125e-4532.70abhydrolase domain containing 12 [Source:NCBI gene... [more]
abhd127.526e-4532.20abhydrolase domain containing 12 [Source:NCBI gene... [more]
abhd122.598e-4432.20abhydrolase domain containing 12 [Source:NCBI gene... [more]
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BLAST of Hydrolase_4 domain-containing protein vs. Ensembl Mouse
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99)
Total hits: 5
Match NameE-valueIdentityDescription
Abhd121.170e-5634.53abhydrolase domain containing 12 [Source:MGI Symbo... [more]
Abhd12b6.107e-3931.55abhydrolase domain containing 12B [Source:MGI Symb... [more]
Abhd12b2.110e-3733.47abhydrolase domain containing 12B [Source:MGI Symb... [more]
Abhd124.039e-3333.48abhydrolase domain containing 12 [Source:MGI Symbo... [more]
Abhd17a3.752e-825.62abhydrolase domain containing 17A [Source:MGI Symb... [more]
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BLAST of Hydrolase_4 domain-containing protein vs. UniProt/SwissProt
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt)
Total hits: 5
Match NameE-valueIdentityDescription
sp|Q8N2K0|ABD12_HUMAN3.207e-5936.53Lysophosphatidylserine lipase ABHD12 OS=Homo sapie... [more]
sp|Q08DW9|ABD12_BOVIN2.122e-5835.56Lysophosphatidylserine lipase ABHD12 OS=Bos taurus... [more]
sp|Q4R766|ABD12_MACFA1.020e-5736.23Lysophosphatidylserine lipase ABHD12 OS=Macaca fas... [more]
sp|Q6AYT7|ABD12_RAT3.960e-5734.83Lysophosphatidylserine lipase ABHD12 OS=Rattus nor... [more]
sp|Q08C93|ABD12_DANRE7.897e-5735.89Lysophosphatidylserine lipase ABHD12 OS=Danio reri... [more]
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BLAST of Hydrolase_4 domain-containing protein vs. TrEMBL
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL)
Total hits: 5
Match NameE-valueIdentityDescription
A0A3S1HTN81.201e-6136.25AB hydrolase-1 domain-containing protein OS=Elysia... [more]
A0A0V1AB743.688e-6035.29Monoacylglycerol lipase ABHD12 OS=Trichinella pata... [more]
A0A2C9LK554.740e-6038.07Hydrolase_4 domain-containing protein OS=Biomphala... [more]
A0A2C9LKK51.162e-5938.07Hydrolase_4 domain-containing protein OS=Biomphala... [more]
A0A0V0S8381.405e-5935.08Monoacylglycerol lipase ABHD12 OS=Trichinella nels... [more]
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BLAST of Hydrolase_4 domain-containing protein vs. Ensembl Cavefish
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99)
Total hits: 4
Match NameE-valueIdentityDescription
abhd121.155e-5735.67abhydrolase domain containing 12 [Source:NCBI gene... [more]
ENSAMXT00000041282.16.052e-4432.31monoacylglycerol lipase ABHD12-like [Source:NCBI g... [more]
ENSAMXT00000021496.21.396e-3929.85monoacylglycerol lipase ABHD12-like [Source:NCBI g... [more]
ENSAMXT00000031554.13.101e-3930.09monoacylglycerol lipase ABHD12-like [Source:NCBI g... [more]
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BLAST of Hydrolase_4 domain-containing protein vs. Ensembl Sea Lamprey
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99)
Total hits: 3
Match NameE-valueIdentityDescription
ENSPMAT00000005892.14.135e-6136.83pep scaffold:Pmarinus_7.0:GL476342:292888:300705:-... [more]
ENSPMAT00000005685.11.275e-931.71pep scaffold:Pmarinus_7.0:GL490231:2586:6570:1 gen... [more]
abhd17b3.167e-624.12abhydrolase domain containing 17B [Source:ZFIN;Acc... [more]
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BLAST of Hydrolase_4 domain-containing protein vs. Ensembl Yeast
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46)
Total hits: 0
Match NameE-valueIdentityDescription
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BLAST of Hydrolase_4 domain-containing protein vs. Ensembl Nematostella
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46)
Total hits: 3
Match NameE-valueIdentityDescription
EDO486973.344e-4038.59Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7... [more]
EDO366465.956e-827.23Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7... [more]
EDO457434.456e-726.83Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7... [more]
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BLAST of Hydrolase_4 domain-containing protein vs. Ensembl Medaka
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99)
Total hits: 5
Match NameE-valueIdentityDescription
abhd121.547e-5836.81abhydrolase domain containing 12 [Source:NCBI gene... [more]
ENSORLT00000035678.11.021e-4631.25abhydrolase domain containing 12B [Source:NCBI gen... [more]
si:ch211-117n7.73.063e-4029.45monoacylglycerol lipase ABHD12 [Source:NCBI gene;A... [more]
si:ch211-117n7.71.072e-3929.14monoacylglycerol lipase ABHD12 [Source:NCBI gene;A... [more]
ENSORLT00000011241.23.991e-3128.39abhydrolase domain containing 12B [Source:NCBI gen... [more]
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BLAST of Hydrolase_4 domain-containing protein vs. Planmine SMEST
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST)
Total hits: 5
Match NameE-valueIdentityDescription
SMESG000015331.10.000e+0100.00SMESG000015331.1[more]
SMESG000015331.10.000e+0100.00SMESG000015331.1[more]
SMESG000046033.13.216e-13760.24SMESG000046033.1[more]
SMESG000046035.13.461e-6941.39SMESG000046035.1[more]
SMESG000018264.12.574e-6539.94SMESG000018264.1[more]
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Sequences
The following sequences are available for this feature:

transcript sequence

>SMED30010564 ID=SMED30010564|Name=Hydrolase_4 domain-containing protein|organism=Schmidtea mediterranea sexual|type=transcript|length=1193bp
TTTAATTTAATTTCATATTACTATTAATACGAAATTAATTAGCCCAGTGT
TAATGATGATATATTTAATTTTACAAGTTATTGGACTATTTACAGTGCTC
ATTTACGTTATCATACCTTTTATTTTATATATTTTTCCTCATATTTTTTC
TAAAATAATATTTTTAGATTTCGTTTATAACATTTTTACAAAATTGGATA
AACCCGAAAATTTTAATTTCAATTTCCAAAACTGGCGAAATTTTAAGATA
GTTAATGAATATTCGAATTGCGAATTAGGAGCATGGGAAATATTGAGCAA
AGTCGATGAGAATCGGAAAGAGTCCTGCTCTTTGAAACAAATTGAATTCG
CTGAAAAGTTTTCCAATGGAAATCCAATCATTCTATATTTACACGGAAAT
TCCATGCATCGAGGTTCTAATCACAGATTACTACTCTATCACGTTTTGAG
GGAATCAGGTTTTCACATATTGACAATTGACTACAGAGGTTTTGCTGATT
CTTCTGGTTCTATCCACAATGAAGACGAAGCTCTCGAAGATGCGTTTGTT
GCCTATAATTATTTAAAACTTACTGCCCCAAATAGCTCCATATTTTTATG
GGGACATTCTCTTGGAACTGGCATTTCTTCATTACTTCTACAAAAATTGT
CAAAAATGAATGAATGTTCAGCGATTTCCGGAGTCATATTAGAATCCCCA
TTTACATCAATCTTAGAGACAATGGATCATATTGGCTTGACATGGCCGTG
GCGATTCATGCCTTATTTCGATCGAATTTTTAAGAAGGCTCTTCTTAATC
AAAAATTAGCGTTTAATTCTATTGAAAACCTCAAGGAAACTAATAATATA
ATACTGATTTTACATGCAGAAGATGATAAAGTTTTATCGTTTAAAATGGG
TAAAAAGTTATATTCTACTTTGCTTTCGGCTGGGAAGGATGTATATTTTA
AGGGTTTTAGCAGTAATCTCAAATATGGTCATGATTATATCGTTAATTGT
CCGGAATTACCTGATATAATAAGAGAATTTACAACTAAAGCTATAAATAC
GAAAAAGATTGGCGACACAAAACATGTTAATAACATCTGATTTCATTCCC
GAATAGAATTGTGTTTAGTTAGCTGTAGTCTGTATTAAAATTTAGTCGTT
TTGTTTTGAATTGAAAAAAGAATAATCTTTGTTTTATTTAGAT
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protein sequence of SMED30010564-orf-1

>SMED30010564-orf-1 ID=SMED30010564-orf-1|Name=SMED30010564-orf-1|organism=Schmidtea mediterranea sexual|type=polypeptide|length=346bp
MMIYLILQVIGLFTVLIYVIIPFILYIFPHIFSKIIFLDFVYNIFTKLDK
PENFNFNFQNWRNFKIVNEYSNCELGAWEILSKVDENRKESCSLKQIEFA
EKFSNGNPIILYLHGNSMHRGSNHRLLLYHVLRESGFHILTIDYRGFADS
SGSIHNEDEALEDAFVAYNYLKLTAPNSSIFLWGHSLGTGISSLLLQKLS
KMNECSAISGVILESPFTSILETMDHIGLTWPWRFMPYFDRIFKKALLNQ
KLAFNSIENLKETNNIILILHAEDDKVLSFKMGKKLYSTLLSAGKDVYFK
GFSSNLKYGHDYIVNCPELPDIIREFTTKAINTKKIGDTKHVNNI*
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Annotated Terms
The following terms have been associated with this transcript:
Vocabulary: molecular function
TermDefinition
GO:0004622lysophospholipase activity
GO:0047372acylglycerol lipase activity
Vocabulary: INTERPRO
TermDefinition
IPR026605ABHD12
IPR029058AB_hydrolase
IPR022742Hydrolase_4
Vocabulary: cellular component
TermDefinition
GO:0016021integral component of membrane
GO:0016020membrane
InterPro
Analysis Name: Schmidtea mediteranean smed_20140614 Interproscan
Date Performed: 2020-05-01
IPR TermIPR DescriptionSourceSource TermSource DescriptionAlignment
IPR022742Serine aminopeptidase, S33PFAMPF12146Hydrolase_4coord: 109..258
e-value: 3.9E-14
score: 52.5
NoneNo IPR availablePANTHERPTHR12277UNCHARACTERIZEDcoord: 7..330
NoneNo IPR availableTMHMMTMhelixcoord: 5..27
IPR026605Lysophosphatidylserine lipase ABHD12PANTHERPTHR12277:SF61MONOACYLGLYCEROL LIPASE ABHD12coord: 7..330
IPR029058Alpha/Beta hydrolase foldSUPERFAMILYSSF53474alpha/beta-Hydrolasescoord: 104..327