Thioredoxin-like protein

Overview


Name	Thioredoxin-like protein
Smed ID	SMED30010531
Length (bp)	607

Neoblast Clusters

▻ Sub-lethal Irradiated Surviving X1 and X2 Cell Population

Overview

Single cell RNA-seq of pluripotent neoblasts and its early progenies

We isolated X1 neoblasts cells enriched in high piwi-1 expression (Neoblast Population), and profiled ∼7,614 individual cells via scRNA-seq. Unsupervised analyses uncovered 12 distinct classes from 7,088 high-quality cells. We designated these classes Nb1 to Nb12 and ordered them based on high (Nb1) to low (Nb12) piwi-1 expression levels. We further defined groups of genes that best classified the cells parsed into 12 distinct cell clusters to generate a scaled expression heat map of discriminative gene sets for each cluster. Expression of each cluster’s gene signatures was validated using multiplex fluorescence in situ hybridization (FISH) co-stained with piwi-1 and largely confirmed the cell clusters revealed by scRNA-seq.

We also tested sub-lethal irradiation exposure. To profile rare pluripotent stem cells (PSCs) and avoid interference from immediate progenitor cells, we determined a time point after sub-lethal irradiation (7 DPI) with minimal piwi-1+ cells, followed by isolation and single-cell RNA-seq of 1,200 individual cells derived from X1 (Piwi-1 high) and X2 (Piwi-1 low) cell populations (Sub-lethal Irradiated Surviving X1 and X2 Cell Population)

Explore this single cell expression dataset with our NB Cluster Shiny App

Neoblast Population

t-SNE plot shows two-dimensional representation of global gene expression relationships among all neoblasts (n = 7,088 after filter). Cluster identity was assigned based on the top 10 marker genes of each cluster (Table S2), followed by inspection of RNA in situ hybridization patterns. Neoblast groups, Nb.

Expression of Thioredoxin-like protein (SMED30010531) t-SNE clustered cells

Violin plots show distribution of expression levels for Thioredoxin-like protein (SMED30010531) in cells (dots) of each of the 12 neoblast clusters.

Sub-lethal Irradiated Surviving X1 and X2 Cell Population

t-SNE plot of surviving X1 and X2 cells (n = 1,039 after QC filter) after sub-lethal irradiation. Colors indicate unbiased cell classification via graph-based clustering. SL, sub-lethal irradiated cell groups.

Expression of Thioredoxin-like protein (SMED30010531) in the t-SNE clustered sub-lethally irradiated X1 and X2 cells.

Violin plots show distribution of expression levels for Thioredoxin-like protein (SMED30010531) in cells (dots) of each of the 10 clusters of sub-leathally irradiated X1 and X2 cells.

Embryonic Expression

Davies et. al., 2017

Hover the mouse over a column in the graph to view average RPKM values per sample.
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Embryonic Stages: Y: yolk. S2-S8: Stages 2-8. C4: asexual adult. SX: virgin, sexually mature adult.
For further information about sample preparation and analysis for the single animal RNA-Seq experiment, please refer to the Materials and Methods

Anatomical Expression

PAGE et. al., 2020

SMED30010531

has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGE

PAGE Curations: 2

Expressed In	Reference Transcript	Gene Models	Published Transcript	Transcriptome	Publication	Specimen	Lifecycle	Evidence
parenchymal cell	SMED30010531	SMESG000079775.1	dd_Smed_v4_5223_0_1	dd_Smed_v4	PMID:29674431 Fincher et al., 2018
muscle cell	SMED30010531	SMESG000079775.1	dd_Smed_v4_5223_0_1	dd_Smed_v4	PMID:29674431 Fincher et al., 2018

Note: Hover over icons to view figure legend

Homology

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BLAST of Thioredoxin-like protein vs. Ensembl Human
Match: TXNL4A (thioredoxin like 4A [Source:HGNC Symbol;Acc:HGNC:30551])

HSP 1 Score: 271.166 bits (692), Expect = 1.076e-93
Identity = 125/142 (88.03%), Postives = 133/142 (93.66%), Query Frame = 1

Query:   61 MSYMLPHLANGWQVDQAILSEEDRVVIIRFGHDWDPQCMVMDETLFKIAEKVKNFAVFYLVDVTEVPDFNKMYELYDPCTVMFFYRNRHIMIDLGTGNNNKINWPIEHDQEMIDIIETVFRGARKGRGLVVSPKDYSTKYRY 486
            MSYMLPHL NGWQVDQAILSEEDRVV+IRFGHDWDP CM MDE L+ IAEKVKNFAV YLVD+TEVPDFNKMYELYDPCTVMFF+RN+HIMIDLGTGNNNKINW +E  QEM+DIIETV+RGARKGRGLVVSPKDYSTKYRY
Sbjct:    1 MSYMLPHLHNGWQVDQAILSEEDRVVVIRFGHDWDPTCMKMDEVLYSIAEKVKNFAVIYLVDITEVPDFNKMYELYDPCTVMFFFRNKHIMIDLGTGNNNKINWAMEDKQEMVDIIETVYRGARKGRGLVVSPKDYSTKYRY 142

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BLAST of Thioredoxin-like protein vs. Ensembl Human
Match: TXNL4A (thioredoxin like 4A [Source:HGNC Symbol;Acc:HGNC:30551])

HSP 1 Score: 166.392 bits (420), Expect = 5.201e-53
Identity = 76/86 (88.37%), Postives = 80/86 (93.02%), Query Frame = 1

Query:   61 MSYMLPHLANGWQVDQAILSEEDRVVIIRFGHDWDPQCMVMDETLFKIAEKVKNFAVFYLVDVTEVPDFNKMYELYDPCTVMFFYR 318
            MSYMLPHL NGWQVDQAILSEEDRVV+IRFGHDWDP CM MDE L+ IAEKVKNFAV YLVD+TEVPDFNKMYELYDPCTVMFF+R
Sbjct:    1 MSYMLPHLHNGWQVDQAILSEEDRVVVIRFGHDWDPTCMKMDEVLYSIAEKVKNFAVIYLVDITEVPDFNKMYELYDPCTVMFFFR 86

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BLAST of Thioredoxin-like protein vs. Ensembl Human
Match: TXNL4A (thioredoxin like 4A [Source:HGNC Symbol;Acc:HGNC:30551])

HSP 1 Score: 162.925 bits (411), Expect = 9.951e-52
Identity = 75/85 (88.24%), Postives = 79/85 (92.94%), Query Frame = 1

Query:   61 MSYMLPHLANGWQVDQAILSEEDRVVIIRFGHDWDPQCMVMDETLFKIAEKVKNFAVFYLVDVTEVPDFNKMYELYDPCTVMFFY 315
            MSYMLPHL NGWQVDQAILSEEDRVV+IRFGHDWDP CM MDE L+ IAEKVKNFAV YLVD+TEVPDFNKMYELYDPCTVMFF+
Sbjct:    1 MSYMLPHLHNGWQVDQAILSEEDRVVVIRFGHDWDPTCMKMDEVLYSIAEKVKNFAVIYLVDITEVPDFNKMYELYDPCTVMFFF 85

[Close]

BLAST of Thioredoxin-like protein vs. Ensembl Human
Match: TXNL4A (thioredoxin like 4A [Source:HGNC Symbol;Acc:HGNC:30551])

HSP 1 Score: 139.428 bits (350), Expect = 1.151e-42
Identity = 63/71 (88.73%), Postives = 68/71 (95.77%), Query Frame = 1

Query:  274 MYELYDPCTVMFFYRNRHIMIDLGTGNNNKINWPIEHDQEMIDIIETVFRGARKGRGLVVSPKDYSTKYRY 486
            MYELYDPCTVMFF+RN+HIMIDLGTGNNNKINW +E  QEM+DIIETV+RGARKGRGLVVSPKDYSTKYRY
Sbjct:    1 MYELYDPCTVMFFFRNKHIMIDLGTGNNNKINWAMEDKQEMVDIIETVYRGARKGRGLVVSPKDYSTKYRY 71

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Query:  274 MYELYDPCTVMFFYRNRHIMIDLGTGNNNKINWPIEHDQEMIDIIETVFRGARKGRGLVVSPKDYSTKYRY 486
            MYELYDPCTVMFF+RN+HIMIDLGTGNNNKINW +E  QEM+DIIETV+RGARKGRGLVVSPKDYSTKYRY
Sbjct:    1 MYELYDPCTVMFFFRNKHIMIDLGTGNNNKINWAMEDKQEMVDIIETVYRGARKGRGLVVSPKDYSTKYRY 71

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BLAST of Thioredoxin-like protein vs. Ensembl Celegans
Match: Y54G2A.75 (pep chromosome:WBcel235:IV:2890888:2891636:1 gene:WBGene00235102.1 transcript:Y54G2A.75.1 gene_biotype:protein_coding transcript_biotype:protein_coding gene_symbol:Y54G2A.75)

HSP 1 Score: 264.618 bits (675), Expect = 1.478e-91
Identity = 119/142 (83.80%), Postives = 132/142 (92.96%), Query Frame = 1

Query:   61 MSYMLPHLANGWQVDQAILSEEDRVVIIRFGHDWDPQCMVMDETLFKIAEKVKNFAVFYLVDVTEVPDFNKMYELYDPCTVMFFYRNRHIMIDLGTGNNNKINWPIEHDQEMIDIIETVFRGARKGRGLVVSPKDYSTKYRY 486
            MSYMLPHL NGWQVDQAIL+EEDRVV++RFGHDWDP CM MDETLFKIA KVKNFAV YLVD+T+VPDFNKMYELYDPCT MFF+RN+HIM+DLGTGNNNKINW +   QE+IDIIETV+RGARKGRGLV+SPKDYSTKY+Y
Sbjct:    1 MSYMLPHLENGWQVDQAILAEEDRVVVVRFGHDWDPTCMQMDETLFKIAPKVKNFAVVYLVDITKVPDFNKMYELYDPCTAMFFFRNKHIMVDLGTGNNNKINWAVTDGQELIDIIETVYRGARKGRGLVISPKDYSTKYKY 142

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BLAST of Thioredoxin-like protein vs. Ensembl Fly
Match: Dim1 (gene:FBgn0031601 transcript:FBtr0077435)

HSP 1 Score: 272.707 bits (696), Expect = 1.123e-94
Identity = 125/142 (88.03%), Postives = 134/142 (94.37%), Query Frame = 1

Query:   61 MSYMLPHLANGWQVDQAILSEEDRVVIIRFGHDWDPQCMVMDETLFKIAEKVKNFAVFYLVDVTEVPDFNKMYELYDPCTVMFFYRNRHIMIDLGTGNNNKINWPIEHDQEMIDIIETVFRGARKGRGLVVSPKDYSTKYRY 486
            MSYMLPHL NGWQVDQAILSEEDRVV+IRFGHDWDP CM MDE ++ IAEKVKNFAV YLVD+TEVPDFNKMYELYDPCTVMFF+RN+HIMIDLGTGNNNKINWP+E  QEMIDI+ETV+RGARKGRGLVVSPKDYSTKYRY
Sbjct:    1 MSYMLPHLHNGWQVDQAILSEEDRVVVIRFGHDWDPACMKMDEVMYSIAEKVKNFAVIYLVDITEVPDFNKMYELYDPCTVMFFFRNKHIMIDLGTGNNNKINWPLEDKQEMIDIVETVYRGARKGRGLVVSPKDYSTKYRY 142

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BLAST of Thioredoxin-like protein vs. Ensembl Zebrafish
Match: txnl4a (thioredoxin-like 4A [Source:ZFIN;Acc:ZDB-GENE-041010-25])

HSP 1 Score: 270.396 bits (690), Expect = 1.396e-93
Identity = 124/142 (87.32%), Postives = 133/142 (93.66%), Query Frame = 1

Query:   61 MSYMLPHLANGWQVDQAILSEEDRVVIIRFGHDWDPQCMVMDETLFKIAEKVKNFAVFYLVDVTEVPDFNKMYELYDPCTVMFFYRNRHIMIDLGTGNNNKINWPIEHDQEMIDIIETVFRGARKGRGLVVSPKDYSTKYRY 486
            MSYMLPHL NGWQVDQAILSEEDRV++IRFGHDWDP CM MDE L+ IAEKVKNFAV YLVD+TEVPDFNKMYELYDPCTVMFF+RN+HIMIDLGTGNNNKINW +E  QEMIDI+ETV+RGARKGRGLVVSPKDYSTKYRY
Sbjct:    1 MSYMLPHLHNGWQVDQAILSEEDRVIVIRFGHDWDPTCMKMDEVLYSIAEKVKNFAVIYLVDITEVPDFNKMYELYDPCTVMFFFRNKHIMIDLGTGNNNKINWTMEDKQEMIDIVETVYRGARKGRGLVVSPKDYSTKYRY 142

[Close]

Query:   61 MSYMLPHLANGWQVDQAILSEEDRVVIIRFGHDWDPQCMVMDETLFKIAEKVKNFAVFYLVDVTEVPDFNKMYELYDPCTVMFFYRNRHIMIDLGTGNNNKINWPIEHDQEMIDIIETVFRGARKGRGLVVSPKDYSTKYRY 486
            MSYMLPHL NGWQVDQAILSEEDRV++IRFGHDWDP CM MDE L+ IAEKVKNFAV YLVD+TEVPDFNKMYELYDPCTVMFF+RN+HIMIDLGTGNNNKINW +E  QEMIDI+ETV+RGARKGRGLVVSPKDYSTKYRY
Sbjct:    1 MSYMLPHLHNGWQVDQAILSEEDRVIVIRFGHDWDPTCMKMDEVLYSIAEKVKNFAVIYLVDITEVPDFNKMYELYDPCTVMFFFRNKHIMIDLGTGNNNKINWTMEDKQEMIDIVETVYRGARKGRGLVVSPKDYSTKYRY 142

[Close]

BLAST of Thioredoxin-like protein vs. Ensembl Zebrafish
Match: txnl4b (thioredoxin-like 4B [Source:ZFIN;Acc:ZDB-GENE-051030-63])

HSP 1 Score: 102.834 bits (255), Expect = 1.464e-27
Identity = 50/136 (36.76%), Postives = 85/136 (62.50%), Query Frame = 1

Query:   61 MSYMLPHLANGWQVDQAILSEEDRVVIIRFGHDWDPQCMVMDETLFKIAEKVKNFAVFYLVDVTEVPDFNKMYEL-YDPCTVMFFYRNRHIMIDLGTGNNNKINWPIEHDQEMIDIIETVFRGARKGRGLVVSPKD 465
            MS  LP L++   +D+AI S  ++V+++RFG D D  C+ +DE L K A  + N A  YLVDV   P +++ +++ + P TV FF+  +H+ +D G+ ++ K     +  Q+ +D+IE ++RGA +G+ +V SP D
Sbjct:    1 MSLFLPKLSSKKDIDEAIKSVAEKVLVLRFGRDEDSVCLQIDEILSKTAHDLSNMASIYLVDVDSAPVYSRYFDISFIPSTV-FFFNGQHMKVDYGSPDHTKFVGSFKSKQDFMDLIEVIYRGAMRGKLIVQSPID 135

[Close]

Query:   61 MSYMLPHLANGWQVDQAILSEEDRVVIIRFGHDWDPQCMVMDETLFKIAEKVKNFAVFYLVDVTEVPDFNKMYEL-YDPCTVMFFYRNRHIMIDLGTGNNNKINWPIEHDQEMIDIIETVFRGARKGRGLVVSPKD 465
            MS  LP L++   +D+AI S  ++V+++RFG D D  C+ +DE L K A  + N A  YLVDV   P +++ +++ + P TV FF+  +H+ +D G+ ++ K     +  Q+ +D+IE ++RGA +G+ +V SP D
Sbjct:    1 MSLFLPKLSSKKDIDEAIKSVAEKVLVLRFGRDEDSVCLQIDEILSKTAHDLSNMASIYLVDVDSAPVYSRYFDISFIPSTV-FFFNGQHMKVDYGSPDHTKFVGSFKSKQDFMDLIEVIYRGAMRGKLIVQSPID 135

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BLAST of Thioredoxin-like protein vs. Ensembl Xenopus
Match: txnl4a (thioredoxin like 4A [Source:NCBI gene;Acc:549400])

HSP 1 Score: 270.011 bits (689), Expect = 2.616e-93
Identity = 124/142 (87.32%), Postives = 133/142 (93.66%), Query Frame = 1

Query:   61 MSYMLPHLANGWQVDQAILSEEDRVVIIRFGHDWDPQCMVMDETLFKIAEKVKNFAVFYLVDVTEVPDFNKMYELYDPCTVMFFYRNRHIMIDLGTGNNNKINWPIEHDQEMIDIIETVFRGARKGRGLVVSPKDYSTKYRY 486
            MSYMLPHL NGWQVDQAILSEEDRV++IRFGHDWDP CM MDE L+ IAEKVKNFAV YLVD+TEVPDFNKMYELYDPCTVMFF+RN+HIMIDLGTGNNNKINW +E  QEMIDI+ETV+RGARKGRGLVVSPKDYSTKYRY
Sbjct:    1 MSYMLPHLHNGWQVDQAILSEEDRVLVIRFGHDWDPTCMKMDEVLYSIAEKVKNFAVIYLVDITEVPDFNKMYELYDPCTVMFFFRNKHIMIDLGTGNNNKINWAMEDKQEMIDIVETVYRGARKGRGLVVSPKDYSTKYRY 142

[Close]

BLAST of Thioredoxin-like protein vs. Ensembl Xenopus
Match: txnl4b (thioredoxin like 4B [Source:NCBI gene;Acc:549092])

HSP 1 Score: 103.219 bits (256), Expect = 1.314e-27
Identity = 50/143 (34.97%), Postives = 88/143 (61.54%), Query Frame = 1

Query:   61 MSYMLPHLANGWQVDQAILSEEDRVVIIRFGHDWDPQCMVMDETLFKIAEKVKNFAVFYLVDVTEVPDFNKMYEL-YDPCTVMFFYRNRHIMIDLGTGNNNKINWPIEHDQEMIDIIETVFRGARKGRGLVVSPKDYSTKYRY 486
            MS++LP L++   VD AI +  ++V+++RFG D D  C+ +D+ L K +  +   A  Y+VDV +VP + + +++ Y P T+ FF+  +H+ +D G+ ++ K     +  Q+ ID+IE ++RGA +G+ +V SP D     RY
Sbjct:    1 MSFLLPKLSSKRDVDHAIKTTSEKVLVLRFGRDEDHVCLQLDDILSKTSHDLSKMATIYIVDVDKVPVYTRYFDISYIPSTI-FFFNGQHMKVDYGSPDHTKFVGSFKTKQDFIDLIEVIYRGAMRGKLIVQSPIDPQNIPRY 142

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BLAST of Thioredoxin-like protein vs. Ensembl Mouse
Match: Txnl4a (thioredoxin-like 4A [Source:MGI Symbol;Acc:MGI:1351613])

HSP 1 Score: 271.166 bits (692), Expect = 7.388e-94
Identity = 125/142 (88.03%), Postives = 133/142 (93.66%), Query Frame = 1

Query:   61 MSYMLPHLANGWQVDQAILSEEDRVVIIRFGHDWDPQCMVMDETLFKIAEKVKNFAVFYLVDVTEVPDFNKMYELYDPCTVMFFYRNRHIMIDLGTGNNNKINWPIEHDQEMIDIIETVFRGARKGRGLVVSPKDYSTKYRY 486
            MSYMLPHL NGWQVDQAILSEEDRVV+IRFGHDWDP CM MDE L+ IAEKVKNFAV YLVD+TEVPDFNKMYELYDPCTVMFF+RN+HIMIDLGTGNNNKINW +E  QEM+DIIETV+RGARKGRGLVVSPKDYSTKYRY
Sbjct:    1 MSYMLPHLHNGWQVDQAILSEEDRVVVIRFGHDWDPTCMKMDEVLYSIAEKVKNFAVIYLVDITEVPDFNKMYELYDPCTVMFFFRNKHIMIDLGTGNNNKINWAMEDKQEMVDIIETVYRGARKGRGLVVSPKDYSTKYRY 142

[Close]

BLAST of Thioredoxin-like protein vs. Ensembl Mouse
Match: Txnl4a (thioredoxin-like 4A [Source:MGI Symbol;Acc:MGI:1351613])

HSP 1 Score: 178.718 bits (452), Expect = 4.030e-58
Identity = 82/93 (88.17%), Postives = 87/93 (93.55%), Query Frame = 1

Query:   61 MSYMLPHLANGWQVDQAILSEEDRVVIIRFGHDWDPQCMVMDETLFKIAEKVKNFAVFYLVDVTEVPDFNKMYELYDPCTVMFFYRNRHIMID 339
            MSYMLPHL NGWQVDQAILSEEDRVV+IRFGHDWDP CM MDE L+ IAEKVKNFAV YLVD+TEVPDFNKMYELYDPCTVMFF+RN+HIMID
Sbjct:    1 MSYMLPHLHNGWQVDQAILSEEDRVVVIRFGHDWDPTCMKMDEVLYSIAEKVKNFAVIYLVDITEVPDFNKMYELYDPCTVMFFFRNKHIMID 93

[Close]

BLAST of Thioredoxin-like protein vs. Ensembl Mouse
Match: Txnl4b (thioredoxin-like 4B [Source:MGI Symbol;Acc:MGI:2443724])

HSP 1 Score: 109.383 bits (272), Expect = 3.597e-30
Identity = 52/136 (38.24%), Postives = 86/136 (63.24%), Query Frame = 1

Query:   61 MSYMLPHLANGWQVDQAILSEEDRVVIIRFGHDWDPQCMVMDETLFKIAEKVKNFAVFYLVDVTEVPDFNKMYEL-YDPCTVMFFYRNRHIMIDLGTGNNNKINWPIEHDQEMIDIIETVFRGARKGRGLVVSPKD 465
            MS++LP L +  +VDQAI S  ++V+++RFG D DP C+ +D+ L K +  +   A  YLVDV   P + + +++ Y P TV FF+  +H+ +D G+ ++ K     +  Q+ ID+IE ++RGA +G+ +V SP D
Sbjct:    1 MSFLLPKLTSKKEVDQAIKSTAEKVLVLRFGRDEDPVCLQLDDILSKTSADLSKMAAIYLVDVDHTPVYTQYFDISYIPSTV-FFFNGQHMKVDYGSPDHTKFVGSFKTKQDFIDLIEVIYRGAMRGKLIVQSPID 135

[Close]

Query:   61 MSYMLPHLANGWQVDQAILSEEDRVVIIRFGHDWDPQCMVMDETLFKIAEKVKNFAVFYLVDVTEVPDFNKMYEL-YDPCTVMFFYRNRHIMIDLGTGNNNKINWPIEHDQEMIDIIETVFRGARKGRGLVVSPKD 465
            MS++LP L +  +VDQAI S  ++V+++RFG D DP C+ +D+ L K +  +   A  YLVDV   P + + +++ Y P TV FF+  +H+ +D G+ ++ K     +  Q+ ID+IE ++RGA +G+ +V SP D
Sbjct:    1 MSFLLPKLTSKKEVDQAIKSTAEKVLVLRFGRDEDPVCLQLDDILSKTSADLSKMAAIYLVDVDHTPVYTQYFDISYIPSTV-FFFNGQHMKVDYGSPDHTKFVGSFKTKQDFIDLIEVIYRGAMRGKLIVQSPID 135

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BLAST of Thioredoxin-like protein vs. UniProt/SwissProt
Match: sp|P83877|TXN4A_MOUSE (Thioredoxin-like protein 4A OS=Mus musculus OX=10090 GN=Txnl4a PE=1 SV=1)

HSP 1 Score: 271.166 bits (692), Expect = 5.168e-93
Identity = 125/142 (88.03%), Postives = 133/142 (93.66%), Query Frame = 1

Query:   61 MSYMLPHLANGWQVDQAILSEEDRVVIIRFGHDWDPQCMVMDETLFKIAEKVKNFAVFYLVDVTEVPDFNKMYELYDPCTVMFFYRNRHIMIDLGTGNNNKINWPIEHDQEMIDIIETVFRGARKGRGLVVSPKDYSTKYRY 486
            MSYMLPHL NGWQVDQAILSEEDRVV+IRFGHDWDP CM MDE L+ IAEKVKNFAV YLVD+TEVPDFNKMYELYDPCTVMFF+RN+HIMIDLGTGNNNKINW +E  QEM+DIIETV+RGARKGRGLVVSPKDYSTKYRY
Sbjct:    1 MSYMLPHLHNGWQVDQAILSEEDRVVVIRFGHDWDPTCMKMDEVLYSIAEKVKNFAVIYLVDITEVPDFNKMYELYDPCTVMFFFRNKHIMIDLGTGNNNKINWAMEDKQEMVDIIETVYRGARKGRGLVVSPKDYSTKYRY 142

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BLAST of Thioredoxin-like protein vs. UniProt/SwissProt
Match: sp|P83876|TXN4A_HUMAN (Thioredoxin-like protein 4A OS=Homo sapiens OX=9606 GN=TXNL4A PE=1 SV=1)

HSP 1 Score: 271.166 bits (692), Expect = 5.168e-93
Identity = 125/142 (88.03%), Postives = 133/142 (93.66%), Query Frame = 1

Query:   61 MSYMLPHLANGWQVDQAILSEEDRVVIIRFGHDWDPQCMVMDETLFKIAEKVKNFAVFYLVDVTEVPDFNKMYELYDPCTVMFFYRNRHIMIDLGTGNNNKINWPIEHDQEMIDIIETVFRGARKGRGLVVSPKDYSTKYRY 486
            MSYMLPHL NGWQVDQAILSEEDRVV+IRFGHDWDP CM MDE L+ IAEKVKNFAV YLVD+TEVPDFNKMYELYDPCTVMFF+RN+HIMIDLGTGNNNKINW +E  QEM+DIIETV+RGARKGRGLVVSPKDYSTKYRY
Sbjct:    1 MSYMLPHLHNGWQVDQAILSEEDRVVVIRFGHDWDPTCMKMDEVLYSIAEKVKNFAVIYLVDITEVPDFNKMYELYDPCTVMFFFRNKHIMIDLGTGNNNKINWAMEDKQEMVDIIETVYRGARKGRGLVVSPKDYSTKYRY 142

[Close]

BLAST of Thioredoxin-like protein vs. UniProt/SwissProt
Match: sp|Q9FE62|YLS8_ARATH (Thioredoxin-like protein YLS8 OS=Arabidopsis thaliana OX=3702 GN=YLS8 PE=2 SV=1)

HSP 1 Score: 244.973 bits (624), Expect = 1.159e-82
Identity = 109/142 (76.76%), Postives = 126/142 (88.73%), Query Frame = 1

Query:   61 MSYMLPHLANGWQVDQAILSEEDRVVIIRFGHDWDPQCMVMDETLFKIAEKVKNFAVFYLVDVTEVPDFNKMYELYDPCTVMFFYRNRHIMIDLGTGNNNKINWPIEHDQEMIDIIETVFRGARKGRGLVVSPKDYSTKYRY 486
            MSY+LPHL +GW VDQ+IL+EE+R+V+IRFGHDWD  CM MDE L  +AE +KNFAV YLVD+TEVPDFN MYELYDP TVMFF+RN+HIMIDLGTGNNNKINW ++  QE IDIIETV+RGARKGRGLV++PKDYSTKYRY
Sbjct:    1 MSYLLPHLHSGWAVDQSILAEEERLVVIRFGHDWDETCMQMDEVLASVAETIKNFAVIYLVDITEVPDFNTMYELYDPSTVMFFFRNKHIMIDLGTGNNNKINWALKDKQEFIDIIETVYRGARKGRGLVIAPKDYSTKYRY 142

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BLAST of Thioredoxin-like protein vs. UniProt/SwissProt
Match: sp|P87215|DIMI_SCHPO (Mitosis protein dim1 OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) OX=284812 GN=dim1 PE=1 SV=1)

HSP 1 Score: 234.187 bits (596), Expect = 1.739e-78
Identity = 106/142 (74.65%), Postives = 125/142 (88.03%), Query Frame = 1

Query:   61 MSYMLPHLANGWQVDQAILSEEDRVVIIRFGHDWDPQCMVMDETLFKIAEKVKNFAVFYLVDVTEVPDFNKMYELYDPCTVMFFYRNRHIMIDLGTGNNNKINWPIEHDQEMIDIIETVFRGARKGRGLVVSPKDYSTKYRY 486
            MSY LPHL +GW VDQAILSE++R+V+IRFG D D +C+  DE L++IAEKV N AV YLVD+ EVPDFNKMYELYD  T+MFFYRN+H+MIDLGTGNNNKINWP+E  QEMIDIIET+FRGARKG+GLV+SPKDYST++RY
Sbjct:    1 MSYFLPHLHSGWHVDQAILSEQERLVVIRFGRDHDEECIKQDEVLYRIAEKVVNMAVIYLVDIDEVPDFNKMYELYDRTTIMFFYRNKHMMIDLGTGNNNKINWPLEDKQEMIDIIETIFRGARKGKGLVISPKDYSTRHRY 142

[Close]

BLAST of Thioredoxin-like protein vs. UniProt/SwissProt
Match: sp|Q75BD8|DIB1_ASHGO (Spliceosomal protein DIB1 OS=Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056) OX=284811 GN=DIB1 PE=3 SV=1)

HSP 1 Score: 201.06 bits (510), Expect = 2.382e-65
Identity = 92/138 (66.67%), Postives = 113/138 (81.88%), Query Frame = 1

Query:   64 SYMLPHLANGWQVDQAILSEEDRVVIIRFGHDWDPQCMVMDETLFKIAEKVKNFAVFYLVDVTEVPDFNKMYELYDPCTVMFFYRNRHIMIDLGTGNNNKINWPIEHDQEMIDIIETVFRGARKGRGLVVSPKDYSTK 477
            S  LPHL +GW VDQAI++EE+R+V+IRFG D D  CM+MDE L+ IAEKV NFA  Y+ D TEVPDFN+MYEL DP TVMFFY+N+H+  D GTGNNNK+N+ +++ QEMIDIIETVFRGAR+ +GLVVSP DY+ K
Sbjct:    3 SVFLPHLHSGWHVDQAIVTEEERLVVIRFGSDSDRSCMLMDEILYSIAEKVVNFAAIYVCDTTEVPDFNEMYELQDPMTVMFFYKNKHMRCDFGTGNNNKMNFVVDNKQEMIDIIETVFRGARRNKGLVVSPYDYNYK 140

[Close]

BLAST of Thioredoxin-like protein vs. TrEMBL
Match: G7YQE2 (U5 snRNP protein DIM1 family OS=Clonorchis sinensis OX=79923 GN=CLF_107061 PE=4 SV=1)

HSP 1 Score: 284.263 bits (726), Expect = 8.752e-95
Identity = 131/142 (92.25%), Postives = 136/142 (95.77%), Query Frame = 1

Query:   61 MSYMLPHLANGWQVDQAILSEEDRVVIIRFGHDWDPQCMVMDETLFKIAEKVKNFAVFYLVDVTEVPDFNKMYELYDPCTVMFFYRNRHIMIDLGTGNNNKINWPIEHDQEMIDIIETVFRGARKGRGLVVSPKDYSTKYRY 486
            MSYML HL NGWQVDQAILSEEDRVV+IRFGHDWDP CMVMDETLFKIAEKVKNFAV YLVD+T+VPDFNKMYELYDPCTVMFFYRN+HIMIDLGTGNNNKINWPIE  QEM+DIIETVFRGARKGRGLVVSPKDYSTKYRY
Sbjct:   71 MSYMLSHLTNGWQVDQAILSEEDRVVVIRFGHDWDPSCMVMDETLFKIAEKVKNFAVIYLVDITKVPDFNKMYELYDPCTVMFFYRNKHIMIDLGTGNNNKINWPIEDGQEMLDIIETVFRGARKGRGLVVSPKDYSTKYRY 212

[Close]

BLAST of Thioredoxin-like protein vs. TrEMBL
Match: A0A2H1CC82 (Thioredoxin-like protein OS=Fasciola hepatica OX=6192 GN=D915_004921 PE=3 SV=1)

HSP 1 Score: 281.567 bits (719), Expect = 9.473e-95
Identity = 131/142 (92.25%), Postives = 136/142 (95.77%), Query Frame = 1

Query:   61 MSYMLPHLANGWQVDQAILSEEDRVVIIRFGHDWDPQCMVMDETLFKIAEKVKNFAVFYLVDVTEVPDFNKMYELYDPCTVMFFYRNRHIMIDLGTGNNNKINWPIEHDQEMIDIIETVFRGARKGRGLVVSPKDYSTKYRY 486
            MSYML HL NGWQVDQAILSEEDRVVIIRFGHDWDP CMVMDETLFKIAEKVKNFAV YLVD+T+VPDFNKMYELYDPCT+MFFYRN+HIMIDLGTGNNNKINWPIE  QEMIDI+ETVFRGARKGRGLVVSPKDYSTKYRY
Sbjct:    1 MSYMLSHLTNGWQVDQAILSEEDRVVIIRFGHDWDPSCMVMDETLFKIAEKVKNFAVIYLVDITKVPDFNKMYELYDPCTIMFFYRNKHIMIDLGTGNNNKINWPIEDAQEMIDIVETVFRGARKGRGLVVSPKDYSTKYRY 142

[Close]

BLAST of Thioredoxin-like protein vs. TrEMBL
Match: A0A4S2LLX3 (Thioredoxin-like protein OS=Opisthorchis felineus OX=147828 GN=CRM22_006246 PE=3 SV=1)

HSP 1 Score: 280.796 bits (717), Expect = 1.731e-94
Identity = 131/142 (92.25%), Postives = 136/142 (95.77%), Query Frame = 1

Query:   61 MSYMLPHLANGWQVDQAILSEEDRVVIIRFGHDWDPQCMVMDETLFKIAEKVKNFAVFYLVDVTEVPDFNKMYELYDPCTVMFFYRNRHIMIDLGTGNNNKINWPIEHDQEMIDIIETVFRGARKGRGLVVSPKDYSTKYRY 486
            MSYML HL NGWQVDQAILSEEDRVV+IRFGHDWDP CMVMDETLFKIAEKVKNFAV YLVD+T+VPDFNKMYELYDPCTVMFFYRN+HIMIDLGTGNNNKINWPIE  QEM+DIIETVFRGARKGRGLVVSPKDYSTKYRY
Sbjct:    1 MSYMLSHLTNGWQVDQAILSEEDRVVVIRFGHDWDPSCMVMDETLFKIAEKVKNFAVIYLVDITKVPDFNKMYELYDPCTVMFFYRNKHIMIDLGTGNNNKINWPIEDGQEMLDIIETVFRGARKGRGLVVSPKDYSTKYRY 142

[Close]

BLAST of Thioredoxin-like protein vs. TrEMBL
Match: Q5DGY8 (Thioredoxin-like protein OS=Schistosoma japonicum OX=6182 GN=EWB00_009574 PE=2 SV=1)

HSP 1 Score: 278.1 bits (710), Expect = 2.252e-93
Identity = 129/142 (90.85%), Postives = 135/142 (95.07%), Query Frame = 1

Query:   61 MSYMLPHLANGWQVDQAILSEEDRVVIIRFGHDWDPQCMVMDETLFKIAEKVKNFAVFYLVDVTEVPDFNKMYELYDPCTVMFFYRNRHIMIDLGTGNNNKINWPIEHDQEMIDIIETVFRGARKGRGLVVSPKDYSTKYRY 486
            MSYML HL NGWQVDQAILSEEDRVV+IRFGHDWDP CMVMDETLFKIAE+VKNFAV YLVD+TEVPDFNKMYELYDPCTVMFFYRN+HIMIDLGTGNNNKINWPIE  QE IDI+ETV+RGARKGRGLVVSPKDYSTKYRY
Sbjct:    1 MSYMLSHLTNGWQVDQAILSEEDRVVVIRFGHDWDPSCMVMDETLFKIAERVKNFAVTYLVDITEVPDFNKMYELYDPCTVMFFYRNKHIMIDLGTGNNNKINWPIEDAQEFIDIVETVYRGARKGRGLVVSPKDYSTKYRY 142

[Close]

BLAST of Thioredoxin-like protein vs. TrEMBL
Match: A0A075A812 (Thioredoxin-like protein OS=Opisthorchis viverrini OX=6198 GN=T265_02055 PE=3 SV=1)

HSP 1 Score: 278.87 bits (712), Expect = 2.966e-93
Identity = 130/141 (92.20%), Postives = 135/141 (95.74%), Query Frame = 1

Query:   61 MSYMLPHLANGWQVDQAILSEEDRVVIIRFGHDWDPQCMVMDETLFKIAEKVKNFAVFYLVDVTEVPDFNKMYELYDPCTVMFFYRNRHIMIDLGTGNNNKINWPIEHDQEMIDIIETVFRGARKGRGLVVSPKDYSTKYR 483
            MSYML HL NGWQVDQAILSEEDRVV+IRFGHDWDP CMVMDETLFKIAEKVKNFAV YLVD+T+VPDFNKMYELYDPCTVMFFYRN+HIMIDLGTGNNNKINWPIE  QEM+DIIETVFRGARKGRGLVVSPKDYSTKYR
Sbjct:    1 MSYMLSHLTNGWQVDQAILSEEDRVVVIRFGHDWDPSCMVMDETLFKIAEKVKNFAVIYLVDITKVPDFNKMYELYDPCTVMFFYRNKHIMIDLGTGNNNKINWPIEDGQEMLDIIETVFRGARKGRGLVVSPKDYSTKYR 141

[Close]

BLAST of Thioredoxin-like protein vs. Ensembl Cavefish
Match: txnl4a (thioredoxin like 4A [Source:NCBI gene;Acc:103026813])

HSP 1 Score: 269.626 bits (688), Expect = 2.046e-93
Identity = 124/142 (87.32%), Postives = 133/142 (93.66%), Query Frame = 1

Query:   61 MSYMLPHLANGWQVDQAILSEEDRVVIIRFGHDWDPQCMVMDETLFKIAEKVKNFAVFYLVDVTEVPDFNKMYELYDPCTVMFFYRNRHIMIDLGTGNNNKINWPIEHDQEMIDIIETVFRGARKGRGLVVSPKDYSTKYRY 486
            MSYMLPHL NGWQVDQAILSEEDRV++IRFGHDWDP CM MDE L+ IAEKVKNFAV YLVD+TEVPDFNKMYELYDPCTVMFF+RN+HIMIDLGTGNNNKINW +E  QEMIDI+ETV+RGARKGRGLVVSPKDYSTKYRY
Sbjct:    1 MSYMLPHLHNGWQVDQAILSEEDRVLVIRFGHDWDPTCMKMDEVLYSIAEKVKNFAVIYLVDITEVPDFNKMYELYDPCTVMFFFRNKHIMIDLGTGNNNKINWTMEDKQEMIDIVETVYRGARKGRGLVVSPKDYSTKYRY 142

[Close]

BLAST of Thioredoxin-like protein vs. Ensembl Cavefish
Match: txnl4b (thioredoxin like 4B [Source:NCBI gene;Acc:103044485])

HSP 1 Score: 105.531 bits (262), Expect = 1.033e-28
Identity = 52/136 (38.24%), Postives = 87/136 (63.97%), Query Frame = 1

Query:   61 MSYMLPHLANGWQVDQAILSEEDRVVIIRFGHDWDPQCMVMDETLFKIAEKVKNFAVFYLVDVTEVPDFNKMYEL-YDPCTVMFFYRNRHIMIDLGTGNNNKINWPIEHDQEMIDIIETVFRGARKGRGLVVSPKD 465
            MS  LP L++  +VD+A+ +  ++V+++RFG D D  CM +DE L K +  +KN    YLVDV +VP + + +++ Y P TV FF+  +H+ +D G+ ++ K     +  Q+ ID+IE ++RGA +G+ +V SP D
Sbjct:    1 MSLFLPKLSSKKEVDEAVKAVAEKVLVLRFGRDEDSVCMQLDEILSKTSHDLKNMTSIYLVDVDKVPVYTRYFDISYIPSTV-FFFNGQHMKVDYGSPDHTKFIGCFKTKQDFIDLIEVIYRGAMRGKLIVQSPID 135

[Close]

BLAST of Thioredoxin-like protein vs. Ensembl Sea Lamprey
Match: txnl4b (thioredoxin-like 4B [Source:ZFIN;Acc:ZDB-GENE-051030-63])

HSP 1 Score: 112.079 bits (279), Expect = 5.453e-32
Identity = 51/135 (37.78%), Postives = 84/135 (62.22%), Query Frame = 1

Query:   61 MSYMLPHLANGWQVDQAILSEEDRVVIIRFGHDWDPQCMVMDETLFKIAEKVKNFAVFYLVDVTEVPDFNKMYELYDPCTVMFFYRNRHIMIDLGTGNNNKINWPIEHDQEMIDIIETVFRGARKGRGLVVSPKD 465
            MSYMLPHL +  +VD AI +  DRV+++RFG   +P C  +DETL+K +  +   A  YLVDV  VP +   +++    + +FF+  +H+ +D G+ ++ K     +  Q+ ID++E ++RGA +G+ +V SP D
Sbjct:    1 MSYMLPHLGSKAEVDAAIRNVADRVLVLRFGRSEEPSCRHLDETLWKTSHDLSKMAEIYLVDVGAVPVYTHYFDITVTPSTIFFFNGQHMKVDYGSPDHTKFVGSFKSKQDFIDLVEVIYRGAMRGKLMVRSPID 135

[Close]

BLAST of Thioredoxin-like protein vs. Ensembl Yeast
Match: DIB1 (17-kDa component of the U4/U6aU5 tri-snRNP; plays an essential role in pre-mRNA splicing; human ortholog TXNL4A (the human U5-specific 15-kDa protein) complements yeast dib1 null mutant [Source:SGD;Acc:S000006286])

HSP 1 Score: 192.586 bits (488), Expect = 7.547e-64
Identity = 88/138 (63.77%), Postives = 109/138 (78.99%), Query Frame = 1

Query:   64 SYMLPHLANGWQVDQAILSEEDRVVIIRFGHDWDPQCMVMDETLFKIAEKVKNFAVFYLVDVTEVPDFNKMYELYDPCTVMFFYRNRHIMIDLGTGNNNKINWPIEHDQEMIDIIETVFRGARKGRGLVVSPKDYSTK 477
            S +LP L  GW VDQAI++E  R+V+IRFG   D QCM+MDE L  IAE+V+NFAV YL D+ EV DF++MYEL DP TVMFFY N+H+M D GTGNNNK+N+ ++  QEMIDI+ET+FRGARK +GLVVSP DY+ K
Sbjct:    3 SVLLPQLRTGWHVDQAIVTETKRLVVIRFGRKNDRQCMIMDELLSSIAERVRNFAVIYLCDIDEVSDFDEMYELTDPMTVMFFYHNKHMMCDFGTGNNNKLNFIVDDKQEMIDILETIFRGARKNKGLVVSPYDYNHK 140

[Close]

BLAST of Thioredoxin-like protein vs. Ensembl Nematostella
Match: EDO41309 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7S4M2])

HSP 1 Score: 264.618 bits (675), Expect = 6.983e-92
Identity = 118/142 (83.10%), Postives = 132/142 (92.96%), Query Frame = 1

Query:   61 MSYMLPHLANGWQVDQAILSEEDRVVIIRFGHDWDPQCMVMDETLFKIAEKVKNFAVFYLVDVTEVPDFNKMYELYDPCTVMFFYRNRHIMIDLGTGNNNKINWPIEHDQEMIDIIETVFRGARKGRGLVVSPKDYSTKYRY 486
            MSYMLPHL NGWQVDQAI+SEED+VV+IRFGHDWDP CM MDE L+ IA+K KNFAVFYLVD+T+ PDFNKMYELYDPCT+MFFYRN+HIMIDLGTGNNNKINW ++  QEM+DI+ETV+RGARKGRGLVVSPKDYSTKYRY
Sbjct:    1 MSYMLPHLQNGWQVDQAIMSEEDKVVVIRFGHDWDPTCMKMDELLYSIADKCKNFAVFYLVDITQCPDFNKMYELYDPCTIMFFYRNKHIMIDLGTGNNNKINWALDDKQEMVDIVETVYRGARKGRGLVVSPKDYSTKYRY 142

[Close]

BLAST of Thioredoxin-like protein vs. Ensembl Nematostella
Match: EDO37547 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7SFF2])

HSP 1 Score: 102.834 bits (255), Expect = 3.773e-28
Identity = 49/135 (36.30%), Postives = 80/135 (59.26%), Query Frame = 1

Query:   61 MSYMLPHLANGWQVDQAILSEEDRVVIIRFGHDWDPQCMVMDETLFKIAEKVKNFAVFYLVDVTEVPDFNKMYELYDPCTVMFFYRNRHIMIDLGTGNNNKINWPIEHDQEMIDIIETVFRGARKGRGLVVSPKD 465
            MSY+L  L    +VD AI S ED+V+++RFG + DP CM +D+ L K  + +   A  Y+VDV EVP + + +++      +FF+  +H+ +D  T ++ K        Q+ ID++E + RGA +G+ +V SP D
Sbjct:    1 MSYLLNKLRTKKEVDNAIKSTEDKVLVLRFGREADPVCMQLDDILAKTNQALSRMADIYIVDVDEVPAYTQYFDVTLIPATVFFFNGQHMKVDYSTPDHTKFIGSFHTKQDFIDLVEVICRGAMRGKLIVTSPID 135

[Close]

BLAST of Thioredoxin-like protein vs. Ensembl Medaka
Match: txnl4a (thioredoxin like 4A [Source:NCBI gene;Acc:101166315])

HSP 1 Score: 271.937 bits (694), Expect = 2.321e-94
Identity = 125/142 (88.03%), Postives = 134/142 (94.37%), Query Frame = 1

Query:   61 MSYMLPHLANGWQVDQAILSEEDRVVIIRFGHDWDPQCMVMDETLFKIAEKVKNFAVFYLVDVTEVPDFNKMYELYDPCTVMFFYRNRHIMIDLGTGNNNKINWPIEHDQEMIDIIETVFRGARKGRGLVVSPKDYSTKYRY 486
            MSYMLPHL NGWQVDQAILSEEDRV++IRFGHDWDP CM MDE L+ IAEKVKNFAV YLVD+TEVPDFNKMYELYDPCTVMFF+RN+HIMIDLGTGNNNKINWP+E  QEMIDI+ETV+RGARKGRGLVVSPKDYSTKYRY
Sbjct:    1 MSYMLPHLHNGWQVDQAILSEEDRVLVIRFGHDWDPTCMKMDEVLYSIAEKVKNFAVIYLVDITEVPDFNKMYELYDPCTVMFFFRNKHIMIDLGTGNNNKINWPMEDKQEMIDIVETVYRGARKGRGLVVSPKDYSTKYRY 142

[Close]

BLAST of Thioredoxin-like protein vs. Ensembl Medaka
Match: txnl4b (thioredoxin like 4B [Source:NCBI gene;Acc:101174817])

HSP 1 Score: 92.8189 bits (229), Expect = 8.333e-24
Identity = 47/136 (34.56%), Postives = 78/136 (57.35%), Query Frame = 1

Query:   61 MSYMLPHLANGWQVDQAILSEEDRVVIIRFGHDWDPQCMVMDETLFKIAEKVKNFAVFYLVDVTEVPDFNKMYEL-YDPCTVMFFYRNRHIMIDLGTGNNNKINWPIEHDQEMIDIIETVFRGARKGRGLVVSPKD 465
            MS  LP L     +D  I    ++VV++RFG D D  C+ +DE L K A  + N A  Y++DV +   + + +++ Y P TV FF+  +H+ +D G+ ++ K     +  Q+  D+IE ++RGA +G+ +V SP D
Sbjct:    1 MSLFLPKLTTKKDIDDVIKGVAEKVVVLRFGRDEDSVCLQLDEILSKTAHDLSNMASIYIIDVDKALIYTRYFDISYIPSTV-FFFNGQHMKVDYGSPDHTKFVGSFKTKQDFKDLIEVIYRGAMRGKMIVRSPID 135

[Close]

BLAST of Thioredoxin-like protein vs. Planmine SMEST
Match: SMESG000079775.1 (SMESG000079775.1)

HSP 1 Score: 254.218 bits (648), Expect = 1.122e-87
Identity = 126/142 (88.73%), Postives = 126/142 (88.73%), Query Frame = 1

Query:   61 MSYMLPHLANGWQVDQAILSEEDRVVIIRFGHDWDPQCMVMDETLFKIAEKVKNFAVFYLVDVTEVPDFNKMYELYDPCTVMFFYRNRHIMIDLGTGNNNKINWPIEHDQEMIDIIETVFRGARKGRGLVVSPKDYSTKYRY 486
            MSYMLPHLANGWQVDQAILSEEDRVVIIRFGHDWDPQCMVMDETLFKIAEKVKNFAVFYLVDVTEVPDFNKM                HIMIDLGTGNNNKINWPIEHDQEMIDIIETVFRGARKGRGLVVSPKDYSTKYRY
Sbjct:    1 MSYMLPHLANGWQVDQAILSEEDRVVIIRFGHDWDPQCMVMDETLFKIAEKVKNFAVFYLVDVTEVPDFNKM----------------HIMIDLGTGNNNKINWPIEHDQEMIDIIETVFRGARKGRGLVVSPKDYSTKYRY 126

[Close]

BLAST of Thioredoxin-like protein vs. Planmine SMEST
Match: SMESG000079775.1 (SMESG000079775.1)

HSP 1 Score: 248.054 bits (632), Expect = 2.489e-85
Identity = 122/142 (85.92%), Postives = 122/142 (85.92%), Query Frame = 1

Query:   61 MSYMLPHLANGWQVDQAILSEEDRVVIIRFGHDWDPQCMVMDETLFKIAEKVKNFAVFYLVDVTEVPDFNKMYELYDPCTVMFFYRNRHIMIDLGTGNNNKINWPIEHDQEMIDIIETVFRGARKGRGLVVSPKDYSTKYRY 486
            MSYMLPHLANGWQVDQAILSEEDRVVIIRFGHDWDPQCMVMDETLFKIAEK                    MYELYDPCTVMFFYRNRHIMIDLGTGNNNKINWPIEHDQEMIDIIETVFRGARKGRGLVVSPKDYSTKYRY
Sbjct:    1 MSYMLPHLANGWQVDQAILSEEDRVVIIRFGHDWDPQCMVMDETLFKIAEK--------------------MYELYDPCTVMFFYRNRHIMIDLGTGNNNKINWPIEHDQEMIDIIETVFRGARKGRGLVVSPKDYSTKYRY 122

[Close]

BLAST of Thioredoxin-like protein vs. Planmine SMEST
Match: SMESG000079775.1 (SMESG000079775.1)

HSP 1 Score: 241.506 bits (615), Expect = 8.556e-83
Identity = 119/139 (85.61%), Postives = 119/139 (85.61%), Query Frame = 1

Query:   70 MLPHLANGWQVDQAILSEEDRVVIIRFGHDWDPQCMVMDETLFKIAEKVKNFAVFYLVDVTEVPDFNKMYELYDPCTVMFFYRNRHIMIDLGTGNNNKINWPIEHDQEMIDIIETVFRGARKGRGLVVSPKDYSTKYRY 486
            MLPHLANGWQVDQAILSEEDRVVIIRFGHDWDPQCMVMDETLFKIAEK                    MYELYDPCTVMFFYRNRHIMIDLGTGNNNKINWPIEHDQEMIDIIETVFRGARKGRGLVVSPKDYSTKYRY
Sbjct:    1 MLPHLANGWQVDQAILSEEDRVVIIRFGHDWDPQCMVMDETLFKIAEK--------------------MYELYDPCTVMFFYRNRHIMIDLGTGNNNKINWPIEHDQEMIDIIETVFRGARKGRGLVVSPKDYSTKYRY 119

[Close]

BLAST of Thioredoxin-like protein vs. Planmine SMEST
Match: SMESG000079775.1 (SMESG000079775.1)

HSP 1 Score: 111.694 bits (278), Expect = 3.966e-33
Identity = 51/51 (100.00%), Postives = 51/51 (100.00%), Query Frame = 1

Query:   61 MSYMLPHLANGWQVDQAILSEEDRVVIIRFGHDWDPQCMVMDETLFKIAEK 213
            MSYMLPHLANGWQVDQAILSEEDRVVIIRFGHDWDPQCMVMDETLFKIAEK
Sbjct:    1 MSYMLPHLANGWQVDQAILSEEDRVVIIRFGHDWDPQCMVMDETLFKIAEK 51

HSP 2 Score: 47.7506 bits (112), Expect = 3.966e-33
Identity = 22/25 (88.00%), Postives = 24/25 (96.00%), Query Frame = 2

Query:  251 QKFLILIKCMSCMILALSCFFIGTG 325
            +KFLILI+CMSCMIL LSCFFIGTG
Sbjct:   51 KKFLILIRCMSCMILVLSCFFIGTG 75

[Close]

BLAST of Thioredoxin-like protein vs. Planmine SMEST
Match: SMESG000079775.1 (SMESG000079775.1)

HSP 1 Score: 104.76 bits (260), Expect = 4.686e-31
Identity = 48/48 (100.00%), Postives = 48/48 (100.00%), Query Frame = 1

Query:   70 MLPHLANGWQVDQAILSEEDRVVIIRFGHDWDPQCMVMDETLFKIAEK 213
            MLPHLANGWQVDQAILSEEDRVVIIRFGHDWDPQCMVMDETLFKIAEK
Sbjct:    1 MLPHLANGWQVDQAILSEEDRVVIIRFGHDWDPQCMVMDETLFKIAEK 48

HSP 2 Score: 47.7506 bits (112), Expect = 4.686e-31
Identity = 22/25 (88.00%), Postives = 24/25 (96.00%), Query Frame = 2

Query:  251 QKFLILIKCMSCMILALSCFFIGTG 325
            +KFLILI+CMSCMIL LSCFFIGTG
Sbjct:   48 KKFLILIRCMSCMILVLSCFFIGTG 72

The following BLAST results are available for this feature:

BLAST of Thioredoxin-like protein vs. Ensembl Human
BLAST of Thioredoxin-like protein vs. Ensembl Celegans
BLAST of Thioredoxin-like protein vs. Ensembl Fly
BLAST of Thioredoxin-like protein vs. Ensembl Zebrafish
BLAST of Thioredoxin-like protein vs. Ensembl Xenopus
BLAST of Thioredoxin-like protein vs. Ensembl Mouse
BLAST of Thioredoxin-like protein vs. UniProt/SwissProt
BLAST of Thioredoxin-like protein vs. TrEMBL
BLAST of Thioredoxin-like protein vs. Ensembl Cavefish
BLAST of Thioredoxin-like protein vs. Ensembl Sea Lamprey
BLAST of Thioredoxin-like protein vs. Ensembl Yeast
BLAST of Thioredoxin-like protein vs. Ensembl Nematostella
BLAST of Thioredoxin-like protein vs. Ensembl Medaka
BLAST of Thioredoxin-like protein vs. Planmine SMEST

BLAST of Thioredoxin-like protein vs. Ensembl Human
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Human e!99)
Total hits: 5


Match Name	E-value	Identity	Description
TXNL4A	1.076e-93	88.03	thioredoxin like 4A [Source:HGNC Symbol;Acc:HGNC:3...	[more]
TXNL4A	5.201e-53	88.37	thioredoxin like 4A [Source:HGNC Symbol;Acc:HGNC:3...	[more]
TXNL4A	9.951e-52	88.24	thioredoxin like 4A [Source:HGNC Symbol;Acc:HGNC:3...	[more]
TXNL4A	1.151e-42	88.73	thioredoxin like 4A [Source:HGNC Symbol;Acc:HGNC:3...	[more]
TXNL4A	1.151e-42	88.73	thioredoxin like 4A [Source:HGNC Symbol;Acc:HGNC:3...	[more]

BLAST of Thioredoxin-like protein vs. Ensembl Celegans
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99)
Total hits: 1


Match Name	E-value	Identity	Description
Y54G2A.75	1.478e-91	83.80	pep chromosome:WBcel235:IV:2890888:2891636:1 gene:...	[more]

BLAST of Thioredoxin-like protein vs. Ensembl Fly
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99)
Total hits: 1


Match Name	E-value	Identity	Description
Dim1	1.123e-94	88.03	gene:FBgn0031601 transcript:FBtr0077435	[more]

BLAST of Thioredoxin-like protein vs. Ensembl Zebrafish
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99)
Total hits: 4


Match Name	E-value	Identity	Description
txnl4a	1.396e-93	87.32	thioredoxin-like 4A [Source:ZFIN;Acc:ZDB-GENE-0410...	[more]
txnl4a	1.396e-93	87.32	thioredoxin-like 4A [Source:ZFIN;Acc:ZDB-GENE-0410...	[more]
txnl4b	1.464e-27	36.76	thioredoxin-like 4B [Source:ZFIN;Acc:ZDB-GENE-0510...	[more]
txnl4b	1.464e-27	36.76	thioredoxin-like 4B [Source:ZFIN;Acc:ZDB-GENE-0510...	[more]

BLAST of Thioredoxin-like protein vs. Ensembl Xenopus
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99)
Total hits: 2


Match Name	E-value	Identity	Description
txnl4a	2.616e-93	87.32	thioredoxin like 4A [Source:NCBI gene;Acc:549400]	[more]
txnl4b	1.314e-27	34.97	thioredoxin like 4B [Source:NCBI gene;Acc:549092]	[more]

BLAST of Thioredoxin-like protein vs. Ensembl Mouse
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99)
Total hits: 4


Match Name	E-value	Identity	Description
Txnl4a	7.388e-94	88.03	thioredoxin-like 4A [Source:MGI Symbol;Acc:MGI:135...	[more]
Txnl4a	4.030e-58	88.17	thioredoxin-like 4A [Source:MGI Symbol;Acc:MGI:135...	[more]
Txnl4b	3.597e-30	38.24	thioredoxin-like 4B [Source:MGI Symbol;Acc:MGI:244...	[more]
Txnl4b	3.597e-30	38.24	thioredoxin-like 4B [Source:MGI Symbol;Acc:MGI:244...	[more]

BLAST of Thioredoxin-like protein vs. UniProt/SwissProt
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt)
Total hits: 5


Match Name	E-value	Identity	Description
sp\|P83877\|TXN4A_MOUSE	5.168e-93	88.03	Thioredoxin-like protein 4A OS=Mus musculus OX=100...	[more]
sp\|P83876\|TXN4A_HUMAN	5.168e-93	88.03	Thioredoxin-like protein 4A OS=Homo sapiens OX=960...	[more]
sp\|Q9FE62\|YLS8_ARATH	1.159e-82	76.76	Thioredoxin-like protein YLS8 OS=Arabidopsis thali...	[more]
sp\|P87215\|DIMI_SCHPO	1.739e-78	74.65	Mitosis protein dim1 OS=Schizosaccharomyces pombe ...	[more]
sp\|Q75BD8\|DIB1_ASHGO	2.382e-65	66.67	Spliceosomal protein DIB1 OS=Ashbya gossypii (stra...	[more]

BLAST of Thioredoxin-like protein vs. TrEMBL
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL)
Total hits: 5


Match Name	E-value	Identity	Description
G7YQE2	8.752e-95	92.25	U5 snRNP protein DIM1 family OS=Clonorchis sinensi...	[more]
A0A2H1CC82	9.473e-95	92.25	Thioredoxin-like protein OS=Fasciola hepatica OX=6...	[more]
A0A4S2LLX3	1.731e-94	92.25	Thioredoxin-like protein OS=Opisthorchis felineus ...	[more]
Q5DGY8	2.252e-93	90.85	Thioredoxin-like protein OS=Schistosoma japonicum ...	[more]
A0A075A812	2.966e-93	92.20	Thioredoxin-like protein OS=Opisthorchis viverrini...	[more]

BLAST of Thioredoxin-like protein vs. Ensembl Cavefish
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99)
Total hits: 2


Match Name	E-value	Identity	Description
txnl4a	2.046e-93	87.32	thioredoxin like 4A [Source:NCBI gene;Acc:10302681...	[more]
txnl4b	1.033e-28	38.24	thioredoxin like 4B [Source:NCBI gene;Acc:10304448...	[more]

BLAST of Thioredoxin-like protein vs. Ensembl Sea Lamprey
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99)
Total hits: 1


Match Name	E-value	Identity	Description
txnl4b	5.453e-32	37.78	thioredoxin-like 4B [Source:ZFIN;Acc:ZDB-GENE-0510...	[more]

BLAST of Thioredoxin-like protein vs. Ensembl Yeast
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46)
Total hits: 1


Match Name	E-value	Identity	Description
DIB1	7.547e-64	63.77	17-kDa component of the U4/U6aU5 tri-snRNP; plays ...	[more]

BLAST of Thioredoxin-like protein vs. Ensembl Nematostella
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46)
Total hits: 2


Match Name	E-value	Identity	Description
EDO41309	6.983e-92	83.10	Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7...	[more]
EDO37547	3.773e-28	36.30	Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7...	[more]

BLAST of Thioredoxin-like protein vs. Ensembl Medaka
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99)
Total hits: 2


Match Name	E-value	Identity	Description
txnl4a	2.321e-94	88.03	thioredoxin like 4A [Source:NCBI gene;Acc:10116631...	[more]
txnl4b	8.333e-24	34.56	thioredoxin like 4B [Source:NCBI gene;Acc:10117481...	[more]

BLAST of Thioredoxin-like protein vs. Planmine SMEST
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST)
Total hits: 5


Match Name	E-value	Identity	Description
SMESG000079775.1	1.122e-87	88.73	SMESG000079775.1	[more]
SMESG000079775.1	2.489e-85	85.92	SMESG000079775.1	[more]
SMESG000079775.1	8.556e-83	85.61	SMESG000079775.1	[more]
SMESG000079775.1	3.966e-33	100.00	SMESG000079775.1	[more]
SMESG000079775.1	4.686e-31	100.00	SMESG000079775.1	[more]

Analyses

This transcript is derived from or has results from the following analyses


Analysis Name	Date Performed
Embryonic Stages	2016-07-25
Schmidtea mediterranea smed_20140614 BLASTX Human e!99	2016-08-08
Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99	2016-08-08
Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL	2020-05-01
Schmidtea mediterranea Sexual smed_20140614 transcriptome	2016-07-25
Schmidtea mediteranean smed_20140614 Interproscan	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST	2020-05-08

Sequences

The following sequences are available for this feature:

transcript sequence
protein sequence

transcript sequence

>SMED30010531 ID=SMED30010531|Name=Thioredoxin-like protein|organism=Schmidtea mediterranea sexual|type=transcript|length=607bp
TGATTATTATTTACTATATTAATTATATAATTTAAATATCAGAAAATTTA
ATATTGAAATATGTCGTATATGCTACCTCATTTAGCAAATGGTTGGCAGG
TGGACCAGGCAATTTTGTCAGAAGAAGATAGAGTTGTTATCATTCGATTT
GGTCATGATTGGGATCCACAGTGCATGGTCATGGATGAAACATTATTTAA
AATTGCTGAAAAAGTAAAAAATTTTGCAGTATTTTATCTAGTTGACGTTA
CAGAAGTTCCTGATTTTAATAAAATGTATGAGCTGTATGATCCTTGCACT
GTCATGTTTTTTTATCGGAACAGGCATATAATGATTGATTTGGGTACTGG
AAATAATAATAAAATCAACTGGCCAATCGAGCATGATCAAGAAATGATTG
ATATTATCGAGACTGTTTTCAGAGGAGCTCGAAAGGGCCGTGGATTAGTT
GTTTCACCTAAAGATTATTCAACAAAATACCGTTATTAATAAATATTTTT
TTAATCATAAATGTCCAAATTAATTTGTTTTAACTTGATATATCAGATTT
AATTTAACTGATTAGTATTAAGTATTATTTGTGTTATATTTTCCAATTGA
GAATATA

protein sequence of SMED30010531-orf-1

>SMED30010531-orf-1 ID=SMED30010531-orf-1|Name=SMED30010531-orf-1|organism=Schmidtea mediterranea sexual|type=polypeptide|length=143bp
MSYMLPHLANGWQVDQAILSEEDRVVIIRFGHDWDPQCMVMDETLFKIAE
KVKNFAVFYLVDVTEVPDFNKMYELYDPCTVMFFYRNRHIMIDLGTGNNN
KINWPIEHDQEMIDIIETVFRGARKGRGLVVSPKDYSTKYRY*

Annotated Terms

The following terms have been associated with this transcript:

Vocabulary: **cellular component**
Term	Definition
GO:0005634	nucleus
GO:0005682	U5 snRNP
GO:0046540	U4/U6 x U5 tri-snRNP complex
GO:0005681	spliceosomal complex

Vocabulary: **biological process**
Term	Definition
GO:0006397	mRNA processing
GO:0008380	RNA splicing
GO:0000398	mRNA splicing, via spliceosome

Vocabulary: **INTERPRO**
Term	Definition
IPR036249	Thioredoxin-like_sf
IPR004123	Dim1
IPR012336	Thioredoxin-like_fold

InterPro

Analysis Name: Schmidtea mediteranean smed_20140614 Interproscan
Date Performed: 2020-05-01


IPR Term	IPR Description	Source	Source Term	Source Description	Alignment
IPR004123	Dim1 family	SMART	SM01410	DIM1_2	coord: 4..136 e-value: 1.6E-94 score: 330.0
IPR004123	Dim1 family	PFAM	PF02966	DIM1	coord: 4..136 e-value: 2.1E-66 score: 221.7
IPR004123	Dim1 family	PIRSF	PIRSF017199	Dim1	coord: 1..142 e-value: 7.1E-74 score: 243.7
IPR004123	Dim1 family	PANTHER	PTHR12052	THIOREDOXIN-LIKE PROTEN 4A, 4B	coord: 1..142
IPR004123	Dim1 family	CDD	cd02954	DIM1	coord: 10..123 e-value: 4.51402E-74 score: 214.466
IPR036249	Thioredoxin-like superfamily	GENE3D	G3DSA:3.40.30.10		coord: 1..141 e-value: 3.2E-75 score: 252.3
IPR036249	Thioredoxin-like superfamily	SUPERFAMILY	SSF52833	Thioredoxin-like	coord: 3..137
None	No IPR available	PANTHER	PTHR12052:SF9		coord: 1..142