Integrator complex subunit 1

Overview
NameIntegrator complex subunit 1
Smed IDSMED30010495
Length (bp)1041
Neoblast Clusters

Zeng et. al., 2018



▻ Overview

▻ Neoblast Population

▻ Sub-lethal Irradiated Surviving X1 and X2 Cell Population

 

 

Overview

 

Single cell RNA-seq of pluripotent neoblasts and its early progenies


We isolated X1 neoblasts cells enriched in high piwi-1 expression (Neoblast Population), and profiled ∼7,614 individual cells via scRNA-seq. Unsupervised analyses uncovered 12 distinct classes from 7,088 high-quality cells. We designated these classes Nb1 to Nb12 and ordered them based on high (Nb1) to low (Nb12) piwi-1 expression levels. We further defined groups of genes that best classified the cells parsed into 12 distinct cell clusters to generate a scaled expression heat map of discriminative gene sets for each cluster. Expression of each cluster’s gene signatures was validated using multiplex fluorescence in situ hybridization (FISH) co-stained with piwi-1 and largely confirmed the cell clusters revealed by scRNA-seq.

We also tested sub-lethal irradiation exposure. To profile rare pluripotent stem cells (PSCs) and avoid interference from immediate progenitor cells, we determined a time point after sub-lethal irradiation (7 DPI) with minimal piwi-1+ cells, followed by isolation and single-cell RNA-seq of 1,200 individual cells derived from X1 (Piwi-1 high) and X2 (Piwi-1 low) cell populations (Sub-lethal Irradiated Surviving X1 and X2 Cell Population)



Explore this single cell expression dataset with our NB Cluster Shiny App



 

Neoblast Population

 

t-SNE plot shows two-dimensional representation of global gene expression relationships among all neoblasts (n = 7,088 after filter). Cluster identity was assigned based on the top 10 marker genes of each cluster (Table S2), followed by inspection of RNA in situ hybridization patterns. Neoblast groups, Nb.


Expression of Integrator complex subunit 1 (SMED30010495) t-SNE clustered cells

Violin plots show distribution of expression levels for Integrator complex subunit 1 (SMED30010495) in cells (dots) of each of the 12 neoblast clusters.

 

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Sub-lethal Irradiated Surviving X1 and X2 Cell Population

 

t-SNE plot of surviving X1 and X2 cells (n = 1,039 after QC filter) after sub-lethal irradiation. Colors indicate unbiased cell classification via graph-based clustering. SL, sub-lethal irradiated cell groups.

Expression of Integrator complex subunit 1 (SMED30010495) in the t-SNE clustered sub-lethally irradiated X1 and X2 cells.

Violin plots show distribution of expression levels for Integrator complex subunit 1 (SMED30010495) in cells (dots) of each of the 10 clusters of sub-leathally irradiated X1 and X2 cells.

 

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Embryonic Expression

Davies et. al., 2017

Hover the mouse over a column in the graph to view average RPKM values per sample.
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Embryonic Stages: Y: yolk. S2-S8: Stages 2-8. C4: asexual adult. SX: virgin, sexually mature adult.
For further information about sample preparation and analysis for the single animal RNA-Seq experiment, please refer to the Materials and Methods

 

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Anatomical Expression

PAGE et. al., 2020



SMED30010495

has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGE



PAGE Curations: 11

  
Expressed InReference TranscriptGene ModelsPublished TranscriptTranscriptomePublicationSpecimenLifecycleEvidence
nervous systemSMED30010495h1SMcG0020326 dd_Smed_v4_2322_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018		FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
cephalic gangliaSMED30010495h1SMcG0020326 dd_Smed_v4_2322_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018		FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
non-ciliated neuronSMED30010495h1SMcG0020326 dd_Smed_v4_2322_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018		FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
nervous systemSMED30010495h1SMcG0020920 dd_Smed_v4_2322_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018		FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
cephalic gangliaSMED30010495h1SMcG0020920 dd_Smed_v4_2322_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018		FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
non-ciliated neuronSMED30010495h1SMcG0020920 dd_Smed_v4_2322_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018		FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
Smed sexual biotypeSMED30010495h1SMcG0020920 Contig42742uc_Smed_v2PMID:29674431
Fincher et al., 2018		FACS sorted cell population adult hermaphrodite single-cell RNA-sequencing evidence
Smed sexual biotypeSMED30010495h1SMcG0020920 Contig42742newmark_estsPMID:29674431
Fincher et al., 2018		FACS sorted cell population adult hermaphrodite single-cell RNA-sequencing evidence
epidermisSMED30010495h1SMcG0020326 dd_Smed_v4_2322_0_1dd_Smed_v4PMID:28292427
Wurtzel et al., 2017		whole organism asexual adult single-cell RNA-sequencing evidence
epidermisSMED30010495h1SMcG0020920 dd_Smed_v4_2322_0_1dd_Smed_v4PMID:28292427
Wurtzel et al., 2017		whole organism asexual adult single-cell RNA-sequencing evidence
epidermisSMED30010495h1SMcG0020920 dd_Smed_v4_2837_0_1dd_Smed_v4PMID:28292427
Wurtzel et al., 2017		whole organism asexual adult single-cell RNA-sequencing evidence
Note: Hover over icons to view figure legend
Homology
[Close]
BLAST of Integrator complex subunit 1 vs. Ensembl Human
Match: INTS1 (integrator complex subunit 1 [Source:HGNC Symbol;Acc:HGNC:24555])

HSP 1 Score: 91.2781 bits (225), Expect = 2.566e-19
Identity = 72/268 (26.87%), Postives = 125/268 (46.64%), Query Frame = 3 
Query:  258 SIKTVLITSNKPIKTYLSQCLAIFVICKKYPSLFTKPVVLDCLVNILSYNGKESSSISSLANSFKPQSSTQVNPSSIGKIKPFHIAICNIILFSLKDVIKWPIQLVKAYLEDSFGDRIWVDLPECYLFVQNIETAFPIPGIDPRTLFPMSAFSDQMVDVINSNGDDKISIPTEQMDHSELRSCNALNKILTGLTAEELLK--------SRYDHCKPSIDAMIAGYIKDILDRRFMADTQSRPIIRTFCTLAAIPEVRGAAVAKSDNWL 1037
            ++K + +T  KP  T     L++  + K  P++F    V++ L ++L    +  +SI+     FK + ++ V+           +  CN+++ + ++   WP   VK Y+EDS G+RIWVD P C  FV NI+TAF    + PR++  +   + ++   + +      S+  E+   +EL            L AEE L          RY+    S++  +   ++D L+RR   D  SR ++R   +     EVR  AV K + WL
Sbjct:  145 AVKQLKVTRAKPDSTLY---LSLMYLAKIKPNIFATEGVIEALCSLL----RRDASIN-----FKAKGNSLVS-----------VLACNLLMAAYEEDENWPEIFVKVYIEDSLGERIWVDSPHCKTFVDNIQTAFNTR-MPPRSVL-LQGEAGRVAGDLGAGSSPHPSLTEEEDSQTEL------------LIAEEKLSPEQEGQLMPRYEELAESVEEYVLDMLRDQLNRRQPIDNVSRNLLRLLTSTCGYKEVRLLAVQKLEMWL 375
[Close]
BLAST of Integrator complex subunit 1 vs. Ensembl Fly
Match: IntS1 (gene:FBgn0034964 transcript:FBtr0072168)

HSP 1 Score: 57.7658 bits (138), Expect = 1.044e-8
Identity = 45/185 (24.32%), Postives = 84/185 (45.41%), Query Frame = 3 
Query:  504 FHIAICNIILFSLKDVIKWPIQLVKAYLEDSFGDRIWVDLPECYLFVQNIETAFP--IPGI-----DPRTLFPMSAFSDQMVDVINSNGDDKISIPTEQMDHSELRSCNALNKILTGLTAEELLKSRYDHCKPSIDAMIAGYIKDILDRRFMADTQSRPIIRTFCTLAAIPEVRGAAVAKSDNWL 1037
             HI   N++     ++ +WP  L++ Y++D+  +R W D   C   V+NI  AF    P I     D  +  P        + V + +GD+     T+ +D S L + +    I   +      KSR+      +   ++  I+D L++R   D  +R  ++  CT + I EVR  ++++ + W+
Sbjct:  179 LHILFANLLTRGFMEISQWPEVLLRIYIDDAVNERYWADNELCAPLVKNICAAFKTRTPHISLLRWDVSSSLPSGQAHRDSMTVDDDSGDNS----TQSLDASPLNTES--EPIPDAMCTT---KSRFS--DAVVQKHVSDAIRDQLNKRQQQDNYTRNFLKFLCTTSGIAEVRCLSISRLELWI 352
[Close]
BLAST of Integrator complex subunit 1 vs. Ensembl Zebrafish
Match: ints1 (integrator complex subunit 1 [Source:ZFIN;Acc:ZDB-GENE-030131-6523])

HSP 1 Score: 85.5001 bits (210), Expect = 1.027e-17
Identity = 75/290 (25.86%), Postives = 127/290 (43.79%), Query Frame = 3 
Query:  195 IDQTVKQENGGSEATLINFL-NSIKTVLITSNKPIKTYLSQCLAIFVICKKYPSLFTKPVVLDCLVNILSYNGKESSSISSLANSFKPQSSTQVNPSSIGKIKPFHIAICNIILFSLKDVIKWPIQLVKAYLEDSFGDRIWVDLPECYLFVQNIETAFPIPGIDPRTLFPMSAFSDQMVDVINSNGDDKISIPTEQMDHSELRSCNALNKILTGLTAEELLK--------SRYDHCKPSIDAMIAGYIKDILDRRFMADTQSRPIIRTFCTLAAIPEVRGAAVAKSDNWL 1037
            +D+    E  G++  +   L  ++K + +   KP  T     L++  + K  P++F    V++ L ++L    +  +SI+     FK + +  V+           +  CN+++ + ++   WP   VK Y+EDS G+RIWVD   C  FV NI+TAF    + P+++   +       D+   N     S P E    +EL            L AEE L          RY+    S++  +   ++D L+RR   D  SR ++R         EVR  AV + + WL
Sbjct:  121 LDEIEAAEAEGNDDRIEGVLCGAVKQLKMNRAKPDMTLY---LSLMFLAKIKPNVFATEGVIEALCSLL----RRDASIN-----FKAKGNNLVS-----------VLACNLLMAAYEEDENWPEIFVKVYIEDSLGERIWVDSSHCKTFVDNIQTAF-TTKMPPKSMLLQTETGRSGGDLSAGNSPHP-STPDEDEGQTEL------------LIAEEKLSPEDDGQVMPRYEELAESVEEYVLDVLRDQLNRRQPMDNVSRNLLRLLTATCGYKEVRLMAVQRLEMWL 373
[Close]
BLAST of Integrator complex subunit 1 vs. Ensembl Zebrafish
Match: ints1 (integrator complex subunit 1 [Source:ZFIN;Acc:ZDB-GENE-030131-6523])

HSP 1 Score: 85.5001 bits (210), Expect = 1.027e-17
Identity = 75/290 (25.86%), Postives = 127/290 (43.79%), Query Frame = 3 
Query:  195 IDQTVKQENGGSEATLINFL-NSIKTVLITSNKPIKTYLSQCLAIFVICKKYPSLFTKPVVLDCLVNILSYNGKESSSISSLANSFKPQSSTQVNPSSIGKIKPFHIAICNIILFSLKDVIKWPIQLVKAYLEDSFGDRIWVDLPECYLFVQNIETAFPIPGIDPRTLFPMSAFSDQMVDVINSNGDDKISIPTEQMDHSELRSCNALNKILTGLTAEELLK--------SRYDHCKPSIDAMIAGYIKDILDRRFMADTQSRPIIRTFCTLAAIPEVRGAAVAKSDNWL 1037
            +D+    E  G++  +   L  ++K + +   KP  T     L++  + K  P++F    V++ L ++L    +  +SI+     FK + +  V+           +  CN+++ + ++   WP   VK Y+EDS G+RIWVD   C  FV NI+TAF    + P+++   +       D+   N     S P E    +EL            L AEE L          RY+    S++  +   ++D L+RR   D  SR ++R         EVR  AV + + WL
Sbjct:  121 LDEIEAAEAEGNDDRIEGVLCGAVKQLKMNRAKPDMTLY---LSLMFLAKIKPNVFATEGVIEALCSLL----RRDASIN-----FKAKGNNLVS-----------VLACNLLMAAYEEDENWPEIFVKVYIEDSLGERIWVDSSHCKTFVDNIQTAF-TTKMPPKSMLLQTETGRSGGDLSAGNSPHP-STPDEDEGQTEL------------LIAEEKLSPEDDGQVMPRYEELAESVEEYVLDVLRDQLNRRQPMDNVSRNLLRLLTATCGYKEVRLMAVQRLEMWL 373
[Close]
BLAST of Integrator complex subunit 1 vs. Ensembl Xenopus
Match: exosc5 (exosome component 5 [Source:Xenbase;Acc:XB-GENE-6257997])

HSP 1 Score: 91.2781 bits (225), Expect = 1.991e-19
Identity = 80/300 (26.67%), Postives = 135/300 (45.00%), Query Frame = 3 
Query:  165 DLNPKTFLTSIDQTVKQENGGSEATLINFL-NSIKTVLITSNKPIKTYLSQCLAIFVICKKYPSLFTKPVVLDCLVNILSYNGKESSSISSLANSFKPQSSTQVNPSSIGKIKPFHIAICNIILFSLKDVIKWPIQLVKAYLEDSFGDRIWVDLPECYLFVQNIETAFPIPGIDPRTLFPMSAFSDQMVDVINSNGDDKISIPTEQMDHSELRSCNALNKILTGLTAEELLK--------SRYDHCKPSIDAMIAGYIKDILDRRFMADTQSRPIIRTFCTLAAIPEVRGAAVAKSDNWL 1037
            ++ P + L  ID +   E+ G++  +   L  ++K + +   KP  T     L++  + K  P++F    V++ L ++L    +  ++I+     FK + ++ V+           +  CN+++ + ++   WP   VK Y+EDS G+RIWVD   C  FV NI+TAF    + P+++   S       D+   N     S+P E+   SEL            L AEE L          RYD    S++      ++D L+RR   D  SR ++R         EVR  AV + + WL
Sbjct:  116 EVPPASLLDDIDAS---ESDGNDDRIEGVLCGAVKQLKMNRAKPDPTLY---LSLMYLAKMKPNIFATEGVIEALCSLL----RRDATIN-----FKAKGNSLVS-----------VLACNLLMAAYEEDENWPEIFVKVYIEDSLGERIWVDSQHCKTFVDNIQTAF-CTKMPPKSMVLHSETGRTAGDLSAGNSPHP-SMPDEEDSQSEL------------LIAEEKLSPEDEGQVMPRYDELAESVEEYALDMLRDQLNRRQPMDNVSRNLLRLLTATCGYKEVRMMAVQRLEMWL 375
[Close]
BLAST of Integrator complex subunit 1 vs. Ensembl Xenopus
Match: exosc5 (exosome component 5 [Source:Xenbase;Acc:XB-GENE-6257997])

HSP 1 Score: 91.2781 bits (225), Expect = 2.059e-19
Identity = 80/300 (26.67%), Postives = 135/300 (45.00%), Query Frame = 3 
Query:  165 DLNPKTFLTSIDQTVKQENGGSEATLINFL-NSIKTVLITSNKPIKTYLSQCLAIFVICKKYPSLFTKPVVLDCLVNILSYNGKESSSISSLANSFKPQSSTQVNPSSIGKIKPFHIAICNIILFSLKDVIKWPIQLVKAYLEDSFGDRIWVDLPECYLFVQNIETAFPIPGIDPRTLFPMSAFSDQMVDVINSNGDDKISIPTEQMDHSELRSCNALNKILTGLTAEELLK--------SRYDHCKPSIDAMIAGYIKDILDRRFMADTQSRPIIRTFCTLAAIPEVRGAAVAKSDNWL 1037
            ++ P + L  ID +   E+ G++  +   L  ++K + +   KP  T     L++  + K  P++F    V++ L ++L    +  ++I+     FK + ++ V+           +  CN+++ + ++   WP   VK Y+EDS G+RIWVD   C  FV NI+TAF    + P+++   S       D+   N     S+P E+   SEL            L AEE L          RYD    S++      ++D L+RR   D  SR ++R         EVR  AV + + WL
Sbjct:  116 EVPPASLLDDIDAS---ESDGNDDRIEGVLCGAVKQLKMNRAKPDPTLY---LSLMYLAKMKPNIFATEGVIEALCSLL----RRDATIN-----FKAKGNSLVS-----------VLACNLLMAAYEEDENWPEIFVKVYIEDSLGERIWVDSQHCKTFVDNIQTAF-CTKMPPKSMVLHSETGRTAGDLSAGNSPHP-SMPDEEDSQSEL------------LIAEEKLSPEDEGQVMPRYDELAESVEEYALDMLRDQLNRRQPMDNVSRNLLRLLTATCGYKEVRMMAVQRLEMWL 375
[Close]
BLAST of Integrator complex subunit 1 vs. Ensembl Xenopus
Match: exosc5 (exosome component 5 [Source:Xenbase;Acc:XB-GENE-6257997])

HSP 1 Score: 91.2781 bits (225), Expect = 2.265e-19
Identity = 80/300 (26.67%), Postives = 135/300 (45.00%), Query Frame = 3 
Query:  165 DLNPKTFLTSIDQTVKQENGGSEATLINFL-NSIKTVLITSNKPIKTYLSQCLAIFVICKKYPSLFTKPVVLDCLVNILSYNGKESSSISSLANSFKPQSSTQVNPSSIGKIKPFHIAICNIILFSLKDVIKWPIQLVKAYLEDSFGDRIWVDLPECYLFVQNIETAFPIPGIDPRTLFPMSAFSDQMVDVINSNGDDKISIPTEQMDHSELRSCNALNKILTGLTAEELLK--------SRYDHCKPSIDAMIAGYIKDILDRRFMADTQSRPIIRTFCTLAAIPEVRGAAVAKSDNWL 1037
            ++ P + L  ID +   E+ G++  +   L  ++K + +   KP  T     L++  + K  P++F    V++ L ++L    +  ++I+     FK + ++ V+           +  CN+++ + ++   WP   VK Y+EDS G+RIWVD   C  FV NI+TAF    + P+++   S       D+   N     S+P E+   SEL            L AEE L          RYD    S++      ++D L+RR   D  SR ++R         EVR  AV + + WL
Sbjct:  116 EVPPASLLDDIDAS---ESDGNDDRIEGVLCGAVKQLKMNRAKPDPTLY---LSLMYLAKMKPNIFATEGVIEALCSLL----RRDATIN-----FKAKGNSLVS-----------VLACNLLMAAYEEDENWPEIFVKVYIEDSLGERIWVDSQHCKTFVDNIQTAF-CTKMPPKSMVLHSETGRTAGDLSAGNSPHP-SMPDEEDSQSEL------------LIAEEKLSPEDEGQVMPRYDELAESVEEYALDMLRDQLNRRQPMDNVSRNLLRLLTATCGYKEVRMMAVQRLEMWL 375
[Close]
BLAST of Integrator complex subunit 1 vs. Ensembl Xenopus
Match: exosc5 (exosome component 5 [Source:Xenbase;Acc:XB-GENE-6257997])

HSP 1 Score: 90.8929 bits (224), Expect = 2.481e-19
Identity = 80/300 (26.67%), Postives = 135/300 (45.00%), Query Frame = 3 
Query:  165 DLNPKTFLTSIDQTVKQENGGSEATLINFL-NSIKTVLITSNKPIKTYLSQCLAIFVICKKYPSLFTKPVVLDCLVNILSYNGKESSSISSLANSFKPQSSTQVNPSSIGKIKPFHIAICNIILFSLKDVIKWPIQLVKAYLEDSFGDRIWVDLPECYLFVQNIETAFPIPGIDPRTLFPMSAFSDQMVDVINSNGDDKISIPTEQMDHSELRSCNALNKILTGLTAEELLK--------SRYDHCKPSIDAMIAGYIKDILDRRFMADTQSRPIIRTFCTLAAIPEVRGAAVAKSDNWL 1037
            ++ P + L  ID +   E+ G++  +   L  ++K + +   KP  T     L++  + K  P++F    V++ L ++L    +  ++I+     FK + ++ V+           +  CN+++ + ++   WP   VK Y+EDS G+RIWVD   C  FV NI+TAF    + P+++   S       D+   N     S+P E+   SEL            L AEE L          RYD    S++      ++D L+RR   D  SR ++R         EVR  AV + + WL
Sbjct:  118 EVPPASLLDDIDAS---ESDGNDDRIEGVLCGAVKQLKMNRAKPDPTLY---LSLMYLAKMKPNIFATEGVIEALCSLL----RRDATIN-----FKAKGNSLVS-----------VLACNLLMAAYEEDENWPEIFVKVYIEDSLGERIWVDSQHCKTFVDNIQTAF-CTKMPPKSMVLHSETGRTAGDLSAGNSPHP-SMPDEEDSQSEL------------LIAEEKLSPEDEGQVMPRYDELAESVEEYALDMLRDQLNRRQPMDNVSRNLLRLLTATCGYKEVRMMAVQRLEMWL 377
[Close]
BLAST of Integrator complex subunit 1 vs. Ensembl Xenopus
Match: exosc5 (exosome component 5 [Source:Xenbase;Acc:XB-GENE-6257997])

HSP 1 Score: 90.8929 bits (224), Expect = 2.536e-19
Identity = 80/300 (26.67%), Postives = 135/300 (45.00%), Query Frame = 3 
Query:  165 DLNPKTFLTSIDQTVKQENGGSEATLINFL-NSIKTVLITSNKPIKTYLSQCLAIFVICKKYPSLFTKPVVLDCLVNILSYNGKESSSISSLANSFKPQSSTQVNPSSIGKIKPFHIAICNIILFSLKDVIKWPIQLVKAYLEDSFGDRIWVDLPECYLFVQNIETAFPIPGIDPRTLFPMSAFSDQMVDVINSNGDDKISIPTEQMDHSELRSCNALNKILTGLTAEELLK--------SRYDHCKPSIDAMIAGYIKDILDRRFMADTQSRPIIRTFCTLAAIPEVRGAAVAKSDNWL 1037
            ++ P + L  ID +   E+ G++  +   L  ++K + +   KP  T     L++  + K  P++F    V++ L ++L    +  ++I+     FK + ++ V+           +  CN+++ + ++   WP   VK Y+EDS G+RIWVD   C  FV NI+TAF    + P+++   S       D+   N     S+P E+   SEL            L AEE L          RYD    S++      ++D L+RR   D  SR ++R         EVR  AV + + WL
Sbjct:  105 EVPPASLLDDIDAS---ESDGNDDRIEGVLCGAVKQLKMNRAKPDPTLY---LSLMYLAKMKPNIFATEGVIEALCSLL----RRDATIN-----FKAKGNSLVS-----------VLACNLLMAAYEEDENWPEIFVKVYIEDSLGERIWVDSQHCKTFVDNIQTAF-CTKMPPKSMVLHSETGRTAGDLSAGNSPHP-SMPDEEDSQSEL------------LIAEEKLSPEDEGQVMPRYDELAESVEEYALDMLRDQLNRRQPMDNVSRNLLRLLTATCGYKEVRMMAVQRLEMWL 364
[Close]
BLAST of Integrator complex subunit 1 vs. Ensembl Mouse
Match: Ints1 (integrator complex subunit 1 [Source:MGI Symbol;Acc:MGI:1915760])

HSP 1 Score: 88.5817 bits (218), Expect = 1.292e-18
Identity = 67/260 (25.77%), Postives = 123/260 (47.31%), Query Frame = 3 
Query:  258 SIKTVLITSNKPIKTYLSQCLAIFVICKKYPSLFTKPVVLDCLVNILSYNGKESSSISSLANSFKPQSSTQVNPSSIGKIKPFHIAICNIILFSLKDVIKWPIQLVKAYLEDSFGDRIWVDLPECYLFVQNIETAFPIPGIDPRTLFPMSAFSDQMVDVINSNGDDKISIPTEQMDHSELRSCNALNKILTGLTAEELLKSRYDHCKPSIDAMIAGYIKDILDRRFMADTQSRPIIRTFCTLAAIPEVRGAAVAKSDNWL 1037
            ++K + +T  KP  T     L++  + K  P++F    V++ L ++L    +  +S++     FK + ++ V+           +  CN+++ + ++   WP   VK Y+EDS G+RIWVD P C  FV NI+TAF    + P+++  +     +    + +      S+  E+   +EL    A  K+      + + + RYD    S++  +   ++D L+RR   D  SR ++R         EVR  AV + + WL
Sbjct:  172 AVKQLKVTRAKPDSTLY---LSLMYLAKIKPNIFATEGVIEALCSLL----RRDASVN-----FKAKGNSLVS-----------VLACNLLMAAYEEDENWPEIFVKVYIEDSLGERIWVDSPHCRTFVDNIQTAFNTK-MPPKSVL-LQGEGARSGGELGAGSSPHPSLTEEEDSQTEL--LIAEEKLSPEQEGQLMPRPRYDELTESVEEYVLDMLRDQLNRRQPIDNVSRNLLRLLTATCGYKEVRLLAVQRLEMWL 404
[Close]
BLAST of Integrator complex subunit 1 vs. Ensembl Mouse
Match: Ints1 (integrator complex subunit 1 [Source:MGI Symbol;Acc:MGI:1915760])

HSP 1 Score: 87.0409 bits (214), Expect = 3.490e-18
Identity = 70/268 (26.12%), Postives = 122/268 (45.52%), Query Frame = 3 
Query:  258 SIKTVLITSNKPIKTYLSQCLAIFVICKKYPSLFTKPVVLDCLVNILSYNGKESSSISSLANSFKPQSSTQVNPSSIGKIKPFHIAICNIILFSLKDVIKWPIQLVKAYLEDSFGDRIWVDLPECYLFVQNIETAFPIPGIDPRTLFPMSAFSDQMVDVINSNGDDKISIPTEQMDHSELRSCNALNKILTGLTAEELLK--------SRYDHCKPSIDAMIAGYIKDILDRRFMADTQSRPIIRTFCTLAAIPEVRGAAVAKSDNWL 1037
            ++K + +T  KP  T     L++  + K  P++F    V++ L ++L    +  +S++     FK + ++ V+           +  CN+++ + ++   WP   VK Y+EDS G+RIWVD P C  FV NI+TAF    + P+++  +     +    + +      S+  E+   +EL            L AEE L          RYD    S++  +   ++D L+RR   D  SR ++R         EVR  AV + + WL
Sbjct:  172 AVKQLKVTRAKPDSTLY---LSLMYLAKIKPNIFATEGVIEALCSLL----RRDASVN-----FKAKGNSLVS-----------VLACNLLMAAYEEDENWPEIFVKVYIEDSLGERIWVDSPHCRTFVDNIQTAFNTK-MPPKSVL-LQGEGARSGGELGAGSSPHPSLTEEEDSQTEL------------LIAEEKLSPEQEGQLMPRYDELTESVEEYVLDMLRDQLNRRQPIDNVSRNLLRLLTATCGYKEVRLLAVQRLEMWL 402
[Close]
BLAST of Integrator complex subunit 1 vs. UniProt/SwissProt
Match: sp|Q8N201|INT1_HUMAN (Integrator complex subunit 1 OS=Homo sapiens OX=9606 GN=INTS1 PE=1 SV=2)

HSP 1 Score: 91.2781 bits (225), Expect = 1.232e-18
Identity = 72/268 (26.87%), Postives = 125/268 (46.64%), Query Frame = 3 
Query:  258 SIKTVLITSNKPIKTYLSQCLAIFVICKKYPSLFTKPVVLDCLVNILSYNGKESSSISSLANSFKPQSSTQVNPSSIGKIKPFHIAICNIILFSLKDVIKWPIQLVKAYLEDSFGDRIWVDLPECYLFVQNIETAFPIPGIDPRTLFPMSAFSDQMVDVINSNGDDKISIPTEQMDHSELRSCNALNKILTGLTAEELLK--------SRYDHCKPSIDAMIAGYIKDILDRRFMADTQSRPIIRTFCTLAAIPEVRGAAVAKSDNWL 1037
            ++K + +T  KP  T     L++  + K  P++F    V++ L ++L    +  +SI+     FK + ++ V+           +  CN+++ + ++   WP   VK Y+EDS G+RIWVD P C  FV NI+TAF    + PR++  +   + ++   + +      S+  E+   +EL            L AEE L          RY+    S++  +   ++D L+RR   D  SR ++R   +     EVR  AV K + WL
Sbjct:  145 AVKQLKVTRAKPDSTLY---LSLMYLAKIKPNIFATEGVIEALCSLL----RRDASIN-----FKAKGNSLVS-----------VLACNLLMAAYEEDENWPEIFVKVYIEDSLGERIWVDSPHCKTFVDNIQTAFNTR-MPPRSVL-LQGEAGRVAGDLGAGSSPHPSLTEEEDSQTEL------------LIAEEKLSPEQEGQLMPRYEELAESVEEYVLDMLRDQLNRRQPIDNVSRNLLRLLTSTCGYKEVRLLAVQKLEMWL 375
[Close]
BLAST of Integrator complex subunit 1 vs. UniProt/SwissProt
Match: sp|Q6P4S8|INT1_MOUSE (Integrator complex subunit 1 OS=Mus musculus OX=10090 GN=Ints1 PE=1 SV=2)

HSP 1 Score: 88.5817 bits (218), Expect = 9.278e-18
Identity = 67/260 (25.77%), Postives = 123/260 (47.31%), Query Frame = 3 
Query:  258 SIKTVLITSNKPIKTYLSQCLAIFVICKKYPSLFTKPVVLDCLVNILSYNGKESSSISSLANSFKPQSSTQVNPSSIGKIKPFHIAICNIILFSLKDVIKWPIQLVKAYLEDSFGDRIWVDLPECYLFVQNIETAFPIPGIDPRTLFPMSAFSDQMVDVINSNGDDKISIPTEQMDHSELRSCNALNKILTGLTAEELLKSRYDHCKPSIDAMIAGYIKDILDRRFMADTQSRPIIRTFCTLAAIPEVRGAAVAKSDNWL 1037
            ++K + +T  KP  T     L++  + K  P++F    V++ L ++L    +  +S++     FK + ++ V+           +  CN+++ + ++   WP   VK Y+EDS G+RIWVD P C  FV NI+TAF    + P+++  +     +    + +      S+  E+   +EL    A  K+      + + + RYD    S++  +   ++D L+RR   D  SR ++R         EVR  AV + + WL
Sbjct:  145 AVKQLKVTRAKPDSTLY---LSLMYLAKIKPNIFATEGVIEALCSLL----RRDASVN-----FKAKGNSLVS-----------VLACNLLMAAYEEDENWPEIFVKVYIEDSLGERIWVDSPHCRTFVDNIQTAFNTK-MPPKSVL-LQGEGARSGGELGAGSSPHPSLTEEEDSQTEL--LIAEEKLSPEQEGQLMPRPRYDELTESVEEYVLDMLRDQLNRRQPIDNVSRNLLRLLTATCGYKEVRLLAVQRLEMWL 377
[Close]
BLAST of Integrator complex subunit 1 vs. UniProt/SwissProt
Match: sp|Q9W1C5|INT1_DROME (Integrator complex subunit 1 OS=Drosophila melanogaster OX=7227 GN=IntS1 PE=1 SV=2)

HSP 1 Score: 57.7658 bits (138), Expect = 1.046e-7
Identity = 45/185 (24.32%), Postives = 84/185 (45.41%), Query Frame = 3 
Query:  504 FHIAICNIILFSLKDVIKWPIQLVKAYLEDSFGDRIWVDLPECYLFVQNIETAFP--IPGI-----DPRTLFPMSAFSDQMVDVINSNGDDKISIPTEQMDHSELRSCNALNKILTGLTAEELLKSRYDHCKPSIDAMIAGYIKDILDRRFMADTQSRPIIRTFCTLAAIPEVRGAAVAKSDNWL 1037
             HI   N++     ++ +WP  L++ Y++D+  +R W D   C   V+NI  AF    P I     D  +  P        + V + +GD+     T+ +D S L + +    I   +      KSR+      +   ++  I+D L++R   D  +R  ++  CT + I EVR  ++++ + W+
Sbjct:  179 LHILFANLLTRGFMEISQWPEVLLRIYIDDAVNERYWADNELCAPLVKNICAAFKTRTPHISLLRWDVSSSLPSGQAHRDSMTVDDDSGDNS----TQSLDASPLNTES--EPIPDAMCTT---KSRFS--DAVVQKHVSDAIRDQLNKRQQQDNYTRNFLKFLCTTSGIAEVRCLSISRLELWI 352
[Close]
BLAST of Integrator complex subunit 1 vs. UniProt/SwissProt
Match: sp|Q54NC8|INT1_DICDI (Integrator complex subunit 1 homolog OS=Dictyostelium discoideum OX=44689 GN=ints1 PE=3 SV=1)

HSP 1 Score: 54.299 bits (129), Expect = 1.124e-6
Identity = 40/137 (29.20%), Postives = 63/137 (45.99%), Query Frame = 3 
Query:  261 IKTVLITSNKPIKTYLSQC--LAIFVICKKYPSLFTKPVVLDCLVNILSYNGKESSSISSLANSFKPQSSTQVNPSSIGKIKPFHIAICNIILFSLKDVIKWPIQLVKAYLEDSFGDRIWVDLPECYLFVQNIETAF 665
            IK++L+     +     +C  +++ VICK+ P+LF+     D L  +LS   K+ + +    N                      I  CN+++     +  WP+ L  AYL+D+ GDR WV+   C  FV NI TAF
Sbjct:  183 IKSMLMVLKSSVGNEPDKCAFISLLVICKRSPTLFSH---FDLLEPLLSLLKKDPTHVQKKNNLLS-------------------ILACNLLMAGYDHIQDWPVYLFCAYLDDAIGDRYWVEDQYCKTFVNNIITAF 297
[Close]
BLAST of Integrator complex subunit 1 vs. TrEMBL
Match: A0A183WHH8 (DUF3677 domain-containing protein OS=Trichobilharzia regenti OX=157069 GN=TRE_LOCUS11583 PE=4 SV=1)

HSP 1 Score: 121.324 bits (303), Expect = 6.535e-27
Identity = 114/434 (26.27%), Postives = 184/434 (42.40%), Query Frame = 3 
Query:   69 VAASNLIALGNSSKPRYNNLSLASTVKKVKTD--DLNPKTFLTSIDQTVK-QENGGSEATLINFLNSIKTVLITSNKPIKTYLSQ-------------------CLAIFVICKKYPSLFTKPVVLDCLVNILSYNGKESSSISSLANSFKPQSSTQVNPSSIGKIKPFHIAICNIILFSLKDVIKWPIQLVKAYLEDSFGDRIWVDLPECYLFVQNIETAFPIPGIDPRTLFPM-------SAFSDQMVDVIN-----------------------SNGDDKISIPT--EQMDHSELRS---------------CNALNKILTG-------LTAEELLKSRYDHCKP--SIDAMIAGYIKDILDRRFMAD--------------------------------TQSRPIIRTFCTLAAIPEVRGAAVAKSDNWLS 1040
            + + +LI+LG  SK +  +++  + VKKVK+   +++P   +T ++  V   +N  +++ +I  LN +KT   + +  + T LS                     L + V+ + +P+LFT+P VLD L+ ILS + +E      L  S    + T +    + +I+  H+ I NI+  +L    KWP +L+K YLEDS  +R+WVD  EC LFV N+ETAFP    DPR LF +       S  ++Q    IN                       ++ D  +SIP   E+ + SE  S               CN  +  +TG        +   L    Y   +P  +++ +I   ++D L RR                                    TQ R ++RT     AI EVRG    + + WL+
Sbjct:   11 IPSGDLISLG--SKSKKVSVAHGNPVKKVKSQSIEVDPSELVTRVEAAVSTNDNNLADSLIIAALNQLKTA--SGHGNLSTSLSSGSDFRPASSGSSSRLLPGVSLGLLVLVQDHPNLFTRPAVLDHLILILSLSPRE------LGISLPSTAITTI----MARIRGLHVLIANILYLALNSQAKWPSKLIKVYLEDSLTNRVWVDQDECRLFVLNLETAFPKTFGDPRGLFTVLSSHQNGSVGANQASGTINYSTPATSGNAVLNVLGFAGIQPSTSSDPSVSIPLHCEKDEISEAVSDVLKNQNNAVSRRTGCNISSNFMTGNNIYSFCQSGSSLAGLTYRSSRPVSAVEVIIINTLRDALGRRSGTTPSSSQANTTTSNTPSSSVISSSTSTSITGGDATQLRNLLRTLGMAVAIAEVRGLVATRMEPWLT 430
[Close]
BLAST of Integrator complex subunit 1 vs. TrEMBL
Match: G4VEU2 (Host cell factor-related OS=Schistosoma mansoni OX=6183 GN=Smp_210070 PE=4 SV=1)

HSP 1 Score: 115.931 bits (289), Expect = 1.725e-24
Identity = 102/422 (24.17%), Postives = 182/422 (43.13%), Query Frame = 3 
Query:   42 MKQNPKKGKVAASNLIALGNSSKPRYNNLSLASTVKKVKTD--DLNPKTFLTSIDQTVK-QENGGSEATLINFLNSIKT-----------VLITSNKPIKTYLSQ------CLAIFVICKKYPSLFTKPVVLDCLVNILSYNGKESSSISSLANSFKPQSSTQVNPSSIGKIKPFHIAICNIILFSLKDVIKWPIQLVKAYLEDSFGDRIWVDLPECYLFVQNIETAFPIPGIDPRTLFPM-------SAFSDQMVDVINSN----------------------GDDKISIPTEQMDHSELRSC---------NALNKILTGLTAEELLKSRYDHCKPSIDAMIAGYIKDILDRR-------FMAD------------------------TQSRPIIRTFCTLAAIPEVRGAAVAKSDNWLS 1040
            M+++ K+  + + +LI+LG+ SK    ++S  +  KK KT   +++P   +T ++  +   +N   E  + + LN +KT              +  +P+ + L         L + V+ + +P++F +P VLD L+ ILS + +E      L  S    + T +    + +I+  H+ I NI+  +L +  KWP +LVK YLEDS  +R+WVD  EC LFV N+ET FP    DPR LF +       S  S+Q     N +                      G D + + + Q +  E+             ++ + + G      +  R++ C+ +++ ++   ++D L RR         A+                         Q R ++RT    A I E+RG    + + WL+
Sbjct:    1 MREH-KRAAIPSGDLISLGSKSKKV--SVSHGNPAKKTKTQSIEVDPSELVTRVEAALSANDNNLVEFLVSSALNQLKTSSGHGTLGSSLSSGSDFRPVHSGLGSRLLPGISLGLLVLAQDHPNVFIRPTVLDQLILILSLSPRE------LGISLPSAAITTI----MARIRGLHVLIANILYLALSNQAKWPSKLVKVYLEDSLANRVWVDQDECRLFVLNLETVFPKTFGDPRGLFSILLSNQNGSIGSNQSGGSANCSTSTPSVNAVFNVLGLTGIQPYLGSDPLVLGSTQYERDEISEAVSNVLKSQSTSVTRTIFGCDISSHVLPRFEACRQAVEVIVINTLRDALGRRSGNTPSTLQANATNASTSSSVISTSSSTSVTSGDAAQLRNLLRTLGMAAGISEIRGLVANRLEPWLT 409
[Close]
BLAST of Integrator complex subunit 1 vs. TrEMBL
Match: A0A3Q0KVB5 (Host cell factor-related OS=Schistosoma mansoni OX=6183 PE=4 SV=1)

HSP 1 Score: 115.546 bits (288), Expect = 2.200e-24
Identity = 102/422 (24.17%), Postives = 182/422 (43.13%), Query Frame = 3 
Query:   42 MKQNPKKGKVAASNLIALGNSSKPRYNNLSLASTVKKVKTD--DLNPKTFLTSIDQTVK-QENGGSEATLINFLNSIKT-----------VLITSNKPIKTYLSQ------CLAIFVICKKYPSLFTKPVVLDCLVNILSYNGKESSSISSLANSFKPQSSTQVNPSSIGKIKPFHIAICNIILFSLKDVIKWPIQLVKAYLEDSFGDRIWVDLPECYLFVQNIETAFPIPGIDPRTLFPM-------SAFSDQMVDVINSN----------------------GDDKISIPTEQMDHSELRSC---------NALNKILTGLTAEELLKSRYDHCKPSIDAMIAGYIKDILDRR-------FMAD------------------------TQSRPIIRTFCTLAAIPEVRGAAVAKSDNWLS 1040
            M+++ K+  + + +LI+LG+ SK    ++S  +  KK KT   +++P   +T ++  +   +N   E  + + LN +KT              +  +P+ + L         L + V+ + +P++F +P VLD L+ ILS + +E      L  S    + T +    + +I+  H+ I NI+  +L +  KWP +LVK YLEDS  +R+WVD  EC LFV N+ET FP    DPR LF +       S  S+Q     N +                      G D + + + Q +  E+             ++ + + G      +  R++ C+ +++ ++   ++D L RR         A+                         Q R ++RT    A I E+RG    + + WL+
Sbjct:    1 MREH-KRAAIPSGDLISLGSKSKKV--SVSHGNPAKKTKTQSIEVDPSELVTRVEAALSANDNNLVEFLVSSALNQLKTSSGHGTLGSSLSSGSDFRPVHSGLGSRLLPGISLGLLVLAQDHPNVFIRPTVLDQLILILSLSPRE------LGISLPSAAITTI----MARIRGLHVLIANILYLALSNQAKWPSKLVKVYLEDSLANRVWVDQDECRLFVLNLETVFPKTFGDPRGLFSILLSNQNGSIGSNQSGGSANCSTSTPSVNAVFNVLGLTGIQPYLGSDPLVLGSTQYERDEISEAVSNVLKSQSTSVTRTIFGCDISSHVLPRFEACRQAVEVIVINTLRDALGRRSGNTPSTLQANATNASTSSSVISTSSSTSVTSGDAAQLRNLLRTLGMAAGISEIRGLVANRLEPWLT 409
[Close]
BLAST of Integrator complex subunit 1 vs. TrEMBL
Match: A0A5K4F1D2 (Host cell factor-related OS=Schistosoma mansoni OX=6183 PE=4 SV=1)

HSP 1 Score: 115.546 bits (288), Expect = 2.205e-24
Identity = 102/422 (24.17%), Postives = 182/422 (43.13%), Query Frame = 3 
Query:   42 MKQNPKKGKVAASNLIALGNSSKPRYNNLSLASTVKKVKTD--DLNPKTFLTSIDQTVK-QENGGSEATLINFLNSIKT-----------VLITSNKPIKTYLSQ------CLAIFVICKKYPSLFTKPVVLDCLVNILSYNGKESSSISSLANSFKPQSSTQVNPSSIGKIKPFHIAICNIILFSLKDVIKWPIQLVKAYLEDSFGDRIWVDLPECYLFVQNIETAFPIPGIDPRTLFPM-------SAFSDQMVDVINSN----------------------GDDKISIPTEQMDHSELRSC---------NALNKILTGLTAEELLKSRYDHCKPSIDAMIAGYIKDILDRR-------FMAD------------------------TQSRPIIRTFCTLAAIPEVRGAAVAKSDNWLS 1040
            M+++ K+  + + +LI+LG+ SK    ++S  +  KK KT   +++P   +T ++  +   +N   E  + + LN +KT              +  +P+ + L         L + V+ + +P++F +P VLD L+ ILS + +E      L  S    + T +    + +I+  H+ I NI+  +L +  KWP +LVK YLEDS  +R+WVD  EC LFV N+ET FP    DPR LF +       S  S+Q     N +                      G D + + + Q +  E+             ++ + + G      +  R++ C+ +++ ++   ++D L RR         A+                         Q R ++RT    A I E+RG    + + WL+
Sbjct:    1 MREH-KRAAIPSGDLISLGSKSKKV--SVSHGNPAKKTKTQSIEVDPSELVTRVEAALSANDNNLVEFLVSSALNQLKTSSGHGTLGSSLSSGSDFRPVHSGLGSRLLPGISLGLLVLAQDHPNVFIRPTVLDQLILILSLSPRE------LGISLPSAAITTI----MARIRGLHVLIANILYLALSNQAKWPSKLVKVYLEDSLANRVWVDQDECRLFVLNLETVFPKTFGDPRGLFSILLSNQNGSIGSNQSGGSANCSTSTPSVNAVFNVLGLTGIQPYLGSDPLVLGSTQYERDEISEAVSNVLKSQSTSVTRTIFGCDISSHVLPRFEACRQAVEVIVINTLRDALGRRSGNTPSTLQANATNASTSSSVISTSSSTSVTSGDAAQLRNLLRTLGMAAGISEIRGLVANRLEPWLT 409
[Close]
BLAST of Integrator complex subunit 1 vs. TrEMBL
Match: A0A5K3F0J6 (Uncharacterized protein OS=Mesocestoides corti OX=53468 PE=4 SV=1)

HSP 1 Score: 109.383 bits (272), Expect = 2.430e-22
Identity = 101/407 (24.82%), Postives = 180/407 (44.23%), Query Frame = 3 
Query:   57 KKGKVAASNLIALGNSSKPRYNNLSLAST-----VKKVKTDDLNPKT-FLTSIDQTVKQEN-GGSEATLINFLNSIKTVLITSN-----------KPIKTYLSQC-------LAIFVICKKY--PSLFTKPVVLDCLVNILSYNGKESSSISSLANSFKPQSSTQVNPSSIGKIKPFHIAICNIILFSLKDVIKWPIQLVKAYLEDSFGDRIWVDLPECYLFVQNIETAFPIPGIDPRTLFPMSAFSDQMVDVINS---------------------NGDDKISIPTEQMDHSELRSCNALN--KILTGLTAEELLKSRYDHCKPSIDAMIAGYIKDILDRRFMADTQ-----------------------------SRPIIRTFCTLAAIPEVRGAAVAKSDNWLS 1040
            KK +   S LI+L + +KP+   LS+ S       KK+++++  P + F++ ++  +   N   +EA ++  LN I+  +I++            +P     S         L + VI K    P +F++  VL+ L  +LS++ +E+S      N       T V      K +  H  + N+++ +L D  KWP +LVK+YLEDS  DR+WVDL EC  FV N+ETAFP    DPR+LF +   S Q+   + +                     N +  ++        + L++ + L+  KI+ G     ++ +R++  + ++D +I   +++ L RR    T                              +R +IRT    + + EVR  +  + + WL+
Sbjct:    5 KKNQPPTSGLISL-SGAKPK--RLSVDSPRGGPPQKKLRSENQVPSSEFVSRVESLLASGNLPEAEALIVAVLNQIRENIISTPSVGTSGSLGLPRPSGHAHSSSRLPPAYSLGLLVIAKHQNAPGVFSRVPVLEQLCTLLSWSLRENS-----INRLPSAVMTNVT----AKFRGLHAFVANLLMVALSDQTKWPTKLVKSYLEDSLSDRVWVDLDECKAFVLNLETAFPPVVGDPRSLFAVLCSSSQLSAGVQAALGLTTTGTSLHQPTSVELPQNTESTVATDLTDAVSAALQAAHLLHPAKIIHGGDPSRMVSNRFESGRAAVDVIILNTLREALSRRGTVSTNLGLSATPAETSSGSGASGVSLPSTGEVVYTRCLIRTLAMTSGLAEVRSLSAQRLEPWLT 399
[Close]
BLAST of Integrator complex subunit 1 vs. Ensembl Cavefish
Match: ints1 (integrator complex subunit 1 [Source:ZFIN;Acc:ZDB-GENE-030131-6523])

HSP 1 Score: 87.4261 bits (215), Expect = 2.092e-18
Identity = 76/283 (26.86%), Postives = 131/283 (46.29%), Query Frame = 3 
Query:  195 IDQTVKQENGGSEATLINFL-NSIKTVLITSNKP-IKTYLSQCLAIFVICKKYPSLFTKPVVLDCLVNILSYNGKESSSISSLANSFKPQSSTQVNPSSIGKIKPFHIAICNIILFSLKDVIKWPIQLVKAYLEDSFGDRIWVDLPECYLFVQNIETAFPIPGIDPRTLFPMSAFSDQMVDVINSNGDDKISIPTEQMDHSELRSCNALNKILTGLTAEELLKSRYDHCKPSIDAMIAGYIKDILDRRFMADTQSRPIIRTFCTLAAIPEVRGAAVAKSDNWL 1037
            +D+    E+ G++  +   L  ++K + +   KP +  YLS    +  + K  P+LF    V++ L ++L    +  +SI+     FK + ++ V+           +  CN+++ + ++   WP   VK Y+EDS G+RIWVD   C  FV NI+TAF    + P+++   +       D+   N     S P E  + +EL     + +       EE +  RYD    S++  +   +KD L+RR   D  SR ++R         EVR  AV + + WL
Sbjct:  121 LDEIEAAESEGNDDRIEGVLCGAVKQLKMNRAKPDVTLYLS----LMFLAKIKPNLFATEGVIEALCSLL----RRDASIN-----FKAKGNSLVS-----------VLACNLLMAAYEEDENWPEIFVKVYIEDSLGERIWVDSSHCKTFVDNIQTAF-TTKMPPKSMLLQTETGRPGGDLSAGNSPHP-STPDEDDNQTEL----LIAEEKLSPEEEEQVMPRYDELAESVEDYVLDMLKDQLNRRQPMDNVSRNLLRLLTATCGYKEVRLMAVQRLEMWL 373
[Close]
BLAST of Integrator complex subunit 1 vs. Ensembl Nematostella
Match: EDO38544 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7SCM5])

HSP 1 Score: 66.2402 bits (160), Expect = 6.146e-12
Identity = 48/157 (30.57%), Postives = 76/157 (48.41%), Query Frame = 3 
Query:  201 QTVKQENGGSEATLINFL-NSIKTVLITSNKPIK-TYLSQCLAIFVICKKYPSLFTKPVVLDCLVNILSYNGKESSSISSLANSFKPQSSTQVNPSSIGKIKPFHIAICNIILFSLKDVIKWPIQLVKAYLEDSFGDRIWVDLPECYLFVQNIETAF 665
            Q ++ E+ G    +   L  S++++    NKP    YL+    +  + K  P LF  P +++ L +IL    K   SI+   N    +++  + P          +   NI+L+  ++  +WP   VK Y+EDS GDR+WVD   C  FV NI TAF
Sbjct:    9 QVLEAESNGDRLRVQGLLLGSVRSLKANRNKPDPIAYLN----LLYLAKHKPDLFGAPRIIEALTSIL----KRDISINIKTN----KTTAALVP----------VMAANILLYIYQEEDEWPESFVKVYIEDSLGDRVWVDNEACQSFVDNILTAF 143
[Close]
BLAST of Integrator complex subunit 1 vs. Ensembl Medaka
Match: ints1 (integrator complex subunit 1 [Source:NCBI gene;Acc:100304460])

HSP 1 Score: 85.1149 bits (209), Expect = 1.260e-17
Identity = 72/290 (24.83%), Postives = 131/290 (45.17%), Query Frame = 3 
Query:  195 IDQTVKQENGGSEATLINFL-NSIKTVLITSNKPIKTYLSQCLAIFVICKKYPSLFTKPVVLDCLVNILSYNGKESSSISSLANSFKPQSSTQVNPSSIGKIKPFHIAICNIILFSLKDVIKWPIQLVKAYLEDSFGDRIWVDLPECYLFVQNIETAFPIPGIDPRTLFPMSAFSDQMVDVINSNGDDKISIPTEQMDHSELRSCNALNKILTGLTAEELLK--------SRYDHCKPSIDAMIAGYIKDILDRRFMADTQSRPIIRTFCTLAAIPEVRGAAVAKSDNWL 1037
            +D+    E+ G++  +   L  ++K + +   KP  T     L++  + K  P++F    +++ L ++L    +  +SI+     FK + ++ V+           +  CN+++ + ++   WP   VK Y+EDS G+RIWVD   C  FV NI+TAF    + P+++  + A + +    +++      S P E    +EL            L AEE L          RY+    S++  +   ++D L+RR   D  SR ++R         E R  AV + + WL
Sbjct:  122 LDEIEASESEGNDDRIEGLLCGAVKQLKLNRAKPDTTLY---LSLMFLAKIKPNVFATEGIIEALCSLL----RRDASIN-----FKAKGNSLVS-----------VLACNLLMAAYEEDENWPEIFVKVYIEDSLGERIWVDSSHCKNFVDNIQTAFGT-KMPPKSML-LQADTGRTAGDLSAGSSPHPSTPDEDDSQTEL------------LIAEEKLSPEDEGQIMPRYEELSESVEDYVLDVLRDQLNRRQPMDNVSRNLLRLLTAACGYKETRLMAVQRLEMWL 374
[Close]
BLAST of Integrator complex subunit 1 vs. Ensembl Medaka
Match: ints1 (integrator complex subunit 1 [Source:NCBI gene;Acc:100304460])

HSP 1 Score: 85.1149 bits (209), Expect = 1.293e-17
Identity = 72/290 (24.83%), Postives = 131/290 (45.17%), Query Frame = 3 
Query:  195 IDQTVKQENGGSEATLINFL-NSIKTVLITSNKPIKTYLSQCLAIFVICKKYPSLFTKPVVLDCLVNILSYNGKESSSISSLANSFKPQSSTQVNPSSIGKIKPFHIAICNIILFSLKDVIKWPIQLVKAYLEDSFGDRIWVDLPECYLFVQNIETAFPIPGIDPRTLFPMSAFSDQMVDVINSNGDDKISIPTEQMDHSELRSCNALNKILTGLTAEELLK--------SRYDHCKPSIDAMIAGYIKDILDRRFMADTQSRPIIRTFCTLAAIPEVRGAAVAKSDNWL 1037
            +D+    E+ G++  +   L  ++K + +   KP  T     L++  + K  P++F    +++ L ++L    +  +SI+     FK + ++ V+           +  CN+++ + ++   WP   VK Y+EDS G+RIWVD   C  FV NI+TAF    + P+++  + A + +    +++      S P E    +EL            L AEE L          RY+    S++  +   ++D L+RR   D  SR ++R         E R  AV + + WL
Sbjct:  122 LDEIEASESEGNDDRIEGLLCGAVKQLKLNRAKPDTTLY---LSLMFLAKIKPNVFATEGIIEALCSLL----RRDASIN-----FKAKGNSLVS-----------VLACNLLMAAYEEDENWPEIFVKVYIEDSLGERIWVDSSHCKNFVDNIQTAFGT-KMPPKSML-LQADTGRTAGDLSAGSSPHPSTPDEDDSQTEL------------LIAEEKLSPEDEGQIMPRYEELSESVEDYVLDVLRDQLNRRQPMDNVSRNLLRLLTAACGYKETRLMAVQRLEMWL 374
[Close]
BLAST of Integrator complex subunit 1 vs. Planmine SMEST
Match: SMESG000016869.1 (SMESG000016869.1)

HSP 1 Score: 681.019 bits (1756), Expect = 0.000e+0
Identity = 333/333 (100.00%), Postives = 333/333 (100.00%), Query Frame = 3 
Query:   42 MKQNPKKGKVAASNLIALGNSSKPRYNNLSLASTVKKVKTDDLNPKTFLTSIDQTVKQENGGSEATLINFLNSIKTVLITSNKPIKTYLSQCLAIFVICKKYPSLFTKPVVLDCLVNILSYNGKESSSISSLANSFKPQSSTQVNPSSIGKIKPFHIAICNIILFSLKDVIKWPIQLVKAYLEDSFGDRIWVDLPECYLFVQNIETAFPIPGIDPRTLFPMSAFSDQMVDVINSNGDDKISIPTEQMDHSELRSCNALNKILTGLTAEELLKSRYDHCKPSIDAMIAGYIKDILDRRFMADTQSRPIIRTFCTLAAIPEVRGAAVAKSDNWLS 1040
            MKQNPKKGKVAASNLIALGNSSKPRYNNLSLASTVKKVKTDDLNPKTFLTSIDQTVKQENGGSEATLINFLNSIKTVLITSNKPIKTYLSQCLAIFVICKKYPSLFTKPVVLDCLVNILSYNGKESSSISSLANSFKPQSSTQVNPSSIGKIKPFHIAICNIILFSLKDVIKWPIQLVKAYLEDSFGDRIWVDLPECYLFVQNIETAFPIPGIDPRTLFPMSAFSDQMVDVINSNGDDKISIPTEQMDHSELRSCNALNKILTGLTAEELLKSRYDHCKPSIDAMIAGYIKDILDRRFMADTQSRPIIRTFCTLAAIPEVRGAAVAKSDNWLS
Sbjct:    1 MKQNPKKGKVAASNLIALGNSSKPRYNNLSLASTVKKVKTDDLNPKTFLTSIDQTVKQENGGSEATLINFLNSIKTVLITSNKPIKTYLSQCLAIFVICKKYPSLFTKPVVLDCLVNILSYNGKESSSISSLANSFKPQSSTQVNPSSIGKIKPFHIAICNIILFSLKDVIKWPIQLVKAYLEDSFGDRIWVDLPECYLFVQNIETAFPIPGIDPRTLFPMSAFSDQMVDVINSNGDDKISIPTEQMDHSELRSCNALNKILTGLTAEELLKSRYDHCKPSIDAMIAGYIKDILDRRFMADTQSRPIIRTFCTLAAIPEVRGAAVAKSDNWLS 333
The following BLAST results are available for this feature:
BLAST of Integrator complex subunit 1 vs. Ensembl Human
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Human e!99)
Total hits: 1
Match NameE-valueIdentityDescription
INTS12.566e-1926.87integrator complex subunit 1 [Source:HGNC Symbol;A... [more]
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BLAST of Integrator complex subunit 1 vs. Ensembl Celegans
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99)
Total hits: 0
Match NameE-valueIdentityDescription
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BLAST of Integrator complex subunit 1 vs. Ensembl Fly
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99)
Total hits: 1
Match NameE-valueIdentityDescription
IntS11.044e-824.32gene:FBgn0034964 transcript:FBtr0072168[more]
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BLAST of Integrator complex subunit 1 vs. Ensembl Zebrafish
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99)
Total hits: 2
Match NameE-valueIdentityDescription
ints11.027e-1725.86integrator complex subunit 1 [Source:ZFIN;Acc:ZDB-... [more]
ints11.027e-1725.86integrator complex subunit 1 [Source:ZFIN;Acc:ZDB-... [more]
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BLAST of Integrator complex subunit 1 vs. Ensembl Xenopus
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99)
Total hits: 5
Match NameE-valueIdentityDescription
exosc51.991e-1926.67exosome component 5 [Source:Xenbase;Acc:XB-GENE-62... [more]
exosc52.059e-1926.67exosome component 5 [Source:Xenbase;Acc:XB-GENE-62... [more]
exosc52.265e-1926.67exosome component 5 [Source:Xenbase;Acc:XB-GENE-62... [more]
exosc52.481e-1926.67exosome component 5 [Source:Xenbase;Acc:XB-GENE-62... [more]
exosc52.536e-1926.67exosome component 5 [Source:Xenbase;Acc:XB-GENE-62... [more]
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BLAST of Integrator complex subunit 1 vs. Ensembl Mouse
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99)
Total hits: 2
Match NameE-valueIdentityDescription
Ints11.292e-1825.77integrator complex subunit 1 [Source:MGI Symbol;Ac... [more]
Ints13.490e-1826.12integrator complex subunit 1 [Source:MGI Symbol;Ac... [more]
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BLAST of Integrator complex subunit 1 vs. UniProt/SwissProt
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt)
Total hits: 4
Match NameE-valueIdentityDescription
sp|Q8N201|INT1_HUMAN1.232e-1826.87Integrator complex subunit 1 OS=Homo sapiens OX=96... [more]
sp|Q6P4S8|INT1_MOUSE9.278e-1825.77Integrator complex subunit 1 OS=Mus musculus OX=10... [more]
sp|Q9W1C5|INT1_DROME1.046e-724.32Integrator complex subunit 1 OS=Drosophila melanog... [more]
sp|Q54NC8|INT1_DICDI1.124e-629.20Integrator complex subunit 1 homolog OS=Dictyostel... [more]
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BLAST of Integrator complex subunit 1 vs. TrEMBL
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL)
Total hits: 5
Match NameE-valueIdentityDescription
A0A183WHH86.535e-2726.27DUF3677 domain-containing protein OS=Trichobilharz... [more]
G4VEU21.725e-2424.17Host cell factor-related OS=Schistosoma mansoni OX... [more]
A0A3Q0KVB52.200e-2424.17Host cell factor-related OS=Schistosoma mansoni OX... [more]
A0A5K4F1D22.205e-2424.17Host cell factor-related OS=Schistosoma mansoni OX... [more]
A0A5K3F0J62.430e-2224.82Uncharacterized protein OS=Mesocestoides corti OX=... [more]
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BLAST of Integrator complex subunit 1 vs. Ensembl Cavefish
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99)
Total hits: 1
Match NameE-valueIdentityDescription
ints12.092e-1826.86integrator complex subunit 1 [Source:ZFIN;Acc:ZDB-... [more]
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BLAST of Integrator complex subunit 1 vs. Ensembl Sea Lamprey
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99)
Total hits: 0
Match NameE-valueIdentityDescription
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BLAST of Integrator complex subunit 1 vs. Ensembl Yeast
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46)
Total hits: 0
Match NameE-valueIdentityDescription
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BLAST of Integrator complex subunit 1 vs. Ensembl Nematostella
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46)
Total hits: 1
Match NameE-valueIdentityDescription
EDO385446.146e-1230.57Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7... [more]
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BLAST of Integrator complex subunit 1 vs. Ensembl Medaka
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99)
Total hits: 2
Match NameE-valueIdentityDescription
ints11.260e-1724.83integrator complex subunit 1 [Source:NCBI gene;Acc... [more]
ints11.293e-1724.83integrator complex subunit 1 [Source:NCBI gene;Acc... [more]
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BLAST of Integrator complex subunit 1 vs. Planmine SMEST
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST)
Total hits: 1
Match NameE-valueIdentityDescription
SMESG000016869.10.000e+0100.00SMESG000016869.1[more]
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Sequences
The following sequences are available for this feature:

transcript sequence

>SMED30010495 ID=SMED30010495|Name=Integrator complex subunit 1|organism=Schmidtea mediterranea sexual|type=transcript|length=1041bp
GTTTGTTTGAATAATATAGTATTTATGCAACTAAATTAAATATGAAACAA
AATCCCAAAAAAGGAAAAGTTGCAGCAAGCAATTTAATTGCACTTGGTAA
TAGTAGTAAACCTCGATATAATAATTTGTCGCTTGCATCAACTGTGAAAA
AAGTTAAAACTGATGATTTAAATCCAAAAACATTCTTAACATCTATAGAT
CAAACTGTTAAACAAGAAAACGGTGGTAGTGAAGCGACATTAATTAATTT
TCTTAATTCCATAAAAACAGTTCTTATAACAAGTAATAAACCTATTAAAA
CATACTTGAGTCAATGCTTGGCTATCTTTGTTATTTGTAAAAAATATCCT
TCTTTGTTTACAAAACCGGTGGTATTAGATTGTCTCGTAAATATATTGAG
TTACAATGGCAAAGAATCATCGAGTATTTCAAGCTTAGCAAACTCATTTA
AACCACAATCATCGACTCAAGTCAATCCATCTTCTATTGGGAAAATAAAA
CCATTTCATATCGCAATATGCAACATAATTCTTTTCAGTTTAAAAGATGT
AATAAAATGGCCAATTCAACTAGTGAAAGCGTATTTAGAGGACAGTTTTG
GTGATCGGATCTGGGTGGATCTGCCGGAATGCTATTTATTCGTACAAAAC
ATCGAAACCGCCTTTCCCATTCCAGGAATTGATCCGCGCACCCTTTTTCC
GATGAGCGCATTCAGTGATCAAATGGTCGACGTGATCAACTCTAACGGGG
ACGATAAAATATCGATTCCCACCGAGCAGATGGACCACAGTGAGCTGCGA
TCTTGCAACGCACTCAACAAGATATTGACCGGACTGACTGCGGAGGAGCT
GCTGAAGTCTCGATACGATCACTGCAAGCCGTCAATCGATGCGATGATTG
CGGGATACATAAAGGATATTCTCGACCGGCGCTTCATGGCAGACACCCAA
TCGAGGCCAATTATTAGGACTTTCTGCACTCTTGCTGCCATTCCAGAGGT
CCGCGGGGCCGCCGTTGCCAAATCTGATAATTGGCTATCGG
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protein sequence of SMED30010495-orf-1

>SMED30010495-orf-1 ID=SMED30010495-orf-1|Name=SMED30010495-orf-1|organism=Schmidtea mediterranea sexual|type=polypeptide|length=333bp
MKQNPKKGKVAASNLIALGNSSKPRYNNLSLASTVKKVKTDDLNPKTFLT
SIDQTVKQENGGSEATLINFLNSIKTVLITSNKPIKTYLSQCLAIFVICK
KYPSLFTKPVVLDCLVNILSYNGKESSSISSLANSFKPQSSTQVNPSSIG
KIKPFHIAICNIILFSLKDVIKWPIQLVKAYLEDSFGDRIWVDLPECYLF
VQNIETAFPIPGIDPRTLFPMSAFSDQMVDVINSNGDDKISIPTEQMDHS
ELRSCNALNKILTGLTAEELLKSRYDHCKPSIDAMIAGYIKDILDRRFMA
DTQSRPIIRTFCTLAAIPEVRGAAVAKSDNWLS
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Annotated Terms
The following terms have been associated with this transcript:
Vocabulary: Planarian Anatomy
TermDefinition
PLANA:0000034epidermis
PLANA:0000099neuron
Vocabulary: INTERPRO
TermDefinition
IPR038902INTS1
Vocabulary: cellular component
TermDefinition
GO:0005634nucleus
GO:0005654nucleoplasm
GO:0016020membrane
GO:0016021integral component of membrane
GO:0031965nuclear membrane
GO:0032039integrator complex
Vocabulary: biological process
TermDefinition
GO:0016180snRNA processing
GO:0034474U2 snRNA 3'-end processing
GO:0042795snRNA transcription from RNA polymerase II promoter
InterPro
Analysis Name: Schmidtea mediteranean smed_20140614 Interproscan
Date Performed: 2020-05-01
IPR TermIPR DescriptionSourceSource TermSource DescriptionAlignment
IPR038902Integrator complex subunit 1PANTHERPTHR21224UNCHARACTERIZEDcoord: 63..332