DNA polymerase epsilon catalytic subunit

Overview
NameDNA polymerase epsilon catalytic subunit
Smed IDSMED30010451
Length (bp)7073
Neoblast Clusters

Zeng et. al., 2018



▻ Overview

▻ Neoblast Population

▻ Sub-lethal Irradiated Surviving X1 and X2 Cell Population

 

 

Overview

 

Single cell RNA-seq of pluripotent neoblasts and its early progenies


We isolated X1 neoblasts cells enriched in high piwi-1 expression (Neoblast Population), and profiled ∼7,614 individual cells via scRNA-seq. Unsupervised analyses uncovered 12 distinct classes from 7,088 high-quality cells. We designated these classes Nb1 to Nb12 and ordered them based on high (Nb1) to low (Nb12) piwi-1 expression levels. We further defined groups of genes that best classified the cells parsed into 12 distinct cell clusters to generate a scaled expression heat map of discriminative gene sets for each cluster. Expression of each cluster’s gene signatures was validated using multiplex fluorescence in situ hybridization (FISH) co-stained with piwi-1 and largely confirmed the cell clusters revealed by scRNA-seq.

We also tested sub-lethal irradiation exposure. To profile rare pluripotent stem cells (PSCs) and avoid interference from immediate progenitor cells, we determined a time point after sub-lethal irradiation (7 DPI) with minimal piwi-1+ cells, followed by isolation and single-cell RNA-seq of 1,200 individual cells derived from X1 (Piwi-1 high) and X2 (Piwi-1 low) cell populations (Sub-lethal Irradiated Surviving X1 and X2 Cell Population)



Explore this single cell expression dataset with our NB Cluster Shiny App



 

Neoblast Population

 

t-SNE plot shows two-dimensional representation of global gene expression relationships among all neoblasts (n = 7,088 after filter). Cluster identity was assigned based on the top 10 marker genes of each cluster (Table S2), followed by inspection of RNA in situ hybridization patterns. Neoblast groups, Nb.


Expression of DNA polymerase epsilon catalytic subunit (SMED30010451) t-SNE clustered cells

Violin plots show distribution of expression levels for DNA polymerase epsilon catalytic subunit (SMED30010451) in cells (dots) of each of the 12 neoblast clusters.

 

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Sub-lethal Irradiated Surviving X1 and X2 Cell Population

 

t-SNE plot of surviving X1 and X2 cells (n = 1,039 after QC filter) after sub-lethal irradiation. Colors indicate unbiased cell classification via graph-based clustering. SL, sub-lethal irradiated cell groups.

Expression of DNA polymerase epsilon catalytic subunit (SMED30010451) in the t-SNE clustered sub-lethally irradiated X1 and X2 cells.

Violin plots show distribution of expression levels for DNA polymerase epsilon catalytic subunit (SMED30010451) in cells (dots) of each of the 10 clusters of sub-leathally irradiated X1 and X2 cells.

 

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Embryonic Expression

Davies et. al., 2017

Hover the mouse over a column in the graph to view average RPKM values per sample.
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Embryonic Stages: Y: yolk. S2-S8: Stages 2-8. C4: asexual adult. SX: virgin, sexually mature adult.
For further information about sample preparation and analysis for the single animal RNA-Seq experiment, please refer to the Materials and Methods

 

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Anatomical Expression

PAGE et. al., 2020



SMED30010451

has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGE



PAGE Curations: 14

  
Expressed InReference TranscriptGene ModelsPublished TranscriptTranscriptomePublicationSpecimenLifecycleEvidence
X1 cellSMED30010451h1SMcG0006943 SmedASXL_017523SmedAsxl_ww_GCZZ01PMID:26114597
Zhu et al., 2015		FACS sorted cell population asexual adult RNA-sequencing evidence
X1 cellSMED30010451h1SMcG0006943 SmedASXL_017522SmedAsxl_ww_GCZZ01PMID:26114597
Zhu et al., 2015		FACS sorted cell population asexual adult RNA-sequencing evidence
X1 cellSMED30010451h1SMcG0006943 SmedASXL_017524SmedAsxl_ww_GCZZ01PMID:26114597
Zhu et al., 2015		FACS sorted cell population asexual adult RNA-sequencing evidence
X1 cellSMED30010451h1SMcG0006943 SmedASXL_017525SmedAsxl_ww_GCZZ01PMID:26114597
Zhu et al., 2015		FACS sorted cell population asexual adult RNA-sequencing evidence
neoblastSMED30010451h1SMcG0006943 dd_Smed_v4_13980_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018		FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
zeta neoblastSMED30010451h1SMcG0006943 dd_Smed_v4_13980_0_1dd_Smed_v4PMID:28292427
Wurtzel et al., 2017		whole organism asexual adult single-cell RNA-sequencing evidence
neoblastSMED30010451h1SMcG0006943 SMED_03297_V2_1GPL14150_gene_modelsPMID:22385657
Wagner et al., 2012		whole organism asexual adult cDNA to DNA expression microarray evidence
neoblastSMED30010451h1SMcG0006943 SMED_03297_V2_1GPL14150PMID:22385657
Wagner et al., 2012		whole organism asexual adult cDNA to DNA expression microarray evidence
neoblastSMED30010451h1SMcG0007239 SMED_03297_V2_1GPL14150_gene_modelsPMID:22385657
Wagner et al., 2012		whole organism asexual adult cDNA to DNA expression microarray evidence
neoblastSMED30010451h1SMcG0007239 SMED_03297_V2_1GPL14150PMID:22385657
Wagner et al., 2012		whole organism asexual adult cDNA to DNA expression microarray evidence
neoblastSMED30010451h1SMcG0006881 SMED_03297_V2_1GPL14150_gene_modelsPMID:22385657
Wagner et al., 2012		whole organism asexual adult cDNA to DNA expression microarray evidence
neoblastSMED30010451h1SMcG0006881 SMED_03297_V2_1GPL14150PMID:22385657
Wagner et al., 2012		whole organism asexual adult cDNA to DNA expression microarray evidence
neoblastSMED30010451h1SMcG0007542 SMED_03297_V2_1GPL14150_gene_modelsPMID:22385657
Wagner et al., 2012		whole organism asexual adult cDNA to DNA expression microarray evidence
neoblastSMED30010451h1SMcG0007542 SMED_03297_V2_1GPL14150PMID:22385657
Wagner et al., 2012		whole organism asexual adult cDNA to DNA expression microarray evidence
Note: Hover over icons to view figure legend
Homology
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BLAST of DNA polymerase epsilon catalytic subunit vs. Ensembl Human
Match: POLE (DNA polymerase epsilon, catalytic subunit [Source:HGNC Symbol;Acc:HGNC:9177])

HSP 1 Score: 2138.61 bits (5540), Expect = 0.000e+0
Identity = 1092/2325 (46.97%), Postives = 1522/2325 (65.46%), Query Frame = 3 
Query:  102 EKILRLKKNDQIDLVYGFDLHSAIKIRTGWLINMKTTDAIDDNKRLVSAMSYYFLEEDGSKFKSTLIFQPYFYIVTKLGCESEIQTYLMKKYSACLHNIEIIEKEDLDLDNHXXXXXXXXXXXXXHTIDDLVRVRKEIMPKIKQNQKNQESDNDYSKMLTEHFQ--GEKKYEYNARKSALDIMDNAIDIREYDVPYHVRVSIDTAIFIGKWYDVHGSMNIKGPNSTHITPRSDIVDHPEPIVLAYDIETTKLPLKFPDATFDQIMMISYMIDGMGYLICNREIIADDIEDFEFTPRPEFPGPFSVFNEPNEKRTIERFFDHIREVKPNIFVTYNGDFFDWPFVETRAVKHGLDMLDYIGFSKDNQNEYKSRSAIHMDCFKWVQRDSYLPIGAQGLKAVCKAKLRYNPVEVDPEEMCKVAREDPRTLANYSVSDAVATYYLYMKYVHPFIFALCTIIPMDPDEVLRKGSGTLCECLLMVEAFNSNIIFPNKQESKLNPLTNDGHVIESETYVGGHVEAIESGVFRSDIPTKFKIVPEMCKFLRKNLKETLVHVLEVEEKVTVDSVLNFDEVYNAIDEKLEDLEETNIRFECPVIYHLDVAAMYPNIILSNRLQPSALVNEKTCGACDFNVPNAKCKRPMTWKWRGEIMPATKSEYYLIQNQLEKEKFPPKKPSLPMRSFYELDKLEQATVEKERLGKFCRNAYNRKHNTRFEERTAVVCQRENAFYVDTVRAFRDRRYQYKDLTKVSKKRLDELISSENGDASEIKRANGMLVLYDSLQLAHKCILNSFYGYVMRKGARWYSMEMAGIVCSTGAAIIKYAREMIEQIGRPLELDTDGIWCILPASFPQGFEFQTNNPKKRNISFSYPGAMLNLMVQQYFTNDQYHDLVDPAKHTYRIRSENSIFFEVDGPYLAMILPASKEMNKKLKKRYAVFNRDRSLAELKGFEVKRNGELNLIKIFQSSVFESFLKGSSISEVYQHVAIVANYWLDLLYSRASTMPDEELFELISEKRCMSKKLEEYGKQKSTSISTARRLAEFLGDEMVKDAGLSFKFIISKKPEGQQVTDRAIPVAIFQAEESVKRFYLSKWLKSKDLQDFDIRNILDWDYYINRFSSNIQKIITIPAALQEVPNPVPRVAHPDWLHKILMEKDNRFKQQRITDIF-----QTITPSQAAADKMK----DIENCAPISKKKPTGVTSLKRARNKDTVDVYGVQLDMDNLPN-HWRDILGDPVPKGNSKSQFIVWLEFHXXXXXXXXXXXDQSELSKENINPATVKRIKTVKKGIQSGISSFFTRSKQSILEDTWQIIQITDTNVSGIYRVWVLIGQEIHNMKLTVPRTFYVNTRIPKAPGENMYFKQVHKLLPRSRIVYHLYEYNLDETIFIKHRSDILSEFIRNEVEGIYELEVPLLLRVYAKLGCMCSIDRNHFTDQQLSN-NPSSFLLNELKFRSTAQHPYLSPNSIKTTFLFQQKSNRNEIIGWFDPCNNRAHLCLVEQSKPNPDKFQANVVQSWFSREREAFLSLKENESLISVVPEHVQFEVSSHKFEISAFKAINKLLVAHRNEVTTPTFIATKSKMTINELYSNLPALQEYPLVPITINETDVSFNVLDWQRIAIKSALQNFVKYEKLLAEMLERARYLHIPVGNMSKFTNDYRGISDSYDLFYGRFLMKNNFIWWCNDKSEPDLGKKENQDRRMMLVDNDVLNGMIYRNKPGCYPTTCVQLEMTYFPINTIIAMHKVMEIDGTNERLFESMIVPAKTIDQAMIQSKCNAAKRNLNLTSNTMYDDVTAAGPAFKILRNVILQWLDDVRNYKNPVADEHLMGFYKWMKNSRSLFYDPALFKSLQKLMRMVFFKLIEQLNNLGVEVIYGTLNKIVLCTKRTDLMDALVHVEYATKTVRNQDIFSQLDFQYVSGWDYLIWQDVSNYSGIKSDLESVTKEEHNSMVLEELSFVNMTNPSLSMGLSQSQNEDSFLTTEIADSSQIEMNWHLSRYLSPMSGVQLRLIEILQYFMLTNWKIVKDEYKLN-------RLAAKNDVAEEAVNTGTILGSDASLYPSSVQRMEDFLQNEMGYKLYLLVSQL-KDVPRMHNAVPLTTXXXXXXXXXXXSNKTPPLLPLKNKVSLHPIVDLIKTTCHILALDTSARYYVNDWKRNMFKLINFDAYSDQAKWRSPYSSDQSMGDAFRSDLIITVPEVICDNCNVTRDLDLCRDLY---QVRIKNSWWFVCPTCDFPYDRNVIQETLIDQVRCICESNVMQDLKCTKCTNGILETSLAGTENCVKCGNAIQVTQNAASLKEKIKIYADIGKHYDLPYLHMMTSWMLQ 7004
            +++ R +  D++DL +GF+       +TGWLINM  T+ +D++KRL SA+ YYF+++DGS+FK  L ++PYFYI T+ GCE E+ ++L KK+   +  +E + KEDLDL NHL+GLK+ +++L FHT++DLV+VRKEI P +K+N++   + + Y+ +L+   Q  G    E    K   D +DN +D+REYDVPYH+R+SID  I +  WY+V    N        IT R D+V+ P+P+VLA+DIETTKLPLKFPDA  DQIMMISYMIDG GYLI NREI+++DIEDFEFTP+PE+ GPF VFNEP+E   I+R+F+H++E KP I VTYNGDFFDWPFVE RA  HGL M   IGF KD+Q EYK+   IHMDC +WV+RDSYLP+G+  LKA  KAKL Y+PVE+DPE+MC++A E P+TLA YSVSDAVATYYLYMKYVHPFIFALCTIIPM+PDEVLRKGSGTLCE LLMV+AF++NIIFPNKQE + N LT+DGHV++SETYVGGHVEA+ESGVFRSDIP +F++ P    FL + +++TL H LE EEKV V+ V NF+EV + I  KL  L++   R ECP+IYHLDV AMYPNIIL+NRLQPSA+V+E TC ACDFN P A C+R M W+WRGE MPA++SEY+ IQ+QLE EKFPP  P  P R+F+EL + EQA  EK RL  +CR AY + H T+ EER   +CQREN+FYVDTVRAFRDRRY++K L KV KK+L   +  E GDA+E+KR   M VLYDSLQLAHKCILNSFYGYVMRKGARWYSMEMAGIVC TGA II  ARE+IEQIGRPLELDTDGIWC+LP SFP+ F F+T N KK  ++ SYPGAMLN+MV++ FTNDQY +L +P+  TY  RSENSIFFEVDGPYLAMILPASKE  KKLKKRYAVFN D SLAELKGFEVKR GEL LIKIFQSSVFE+FLKGS++ EVY  VA VA+YWLD+LYS+A+ MPD ELFELISE R MS+KLE+YG+QKSTSISTA+RLAEFLGD+MVKDAGLS ++IIS+KPEG  VT+RAIP+AIFQAE +V++ +L KWLKS  LQDFDIR ILDWDYYI R  S IQKIITIPAALQ+V NPVPRV HPDWLHK L+EK++ +KQ++I+++F     + +T ++A+ D  +    D+E+   +    P    ++KR R    V     +   D  P   W++ILG P   G S+ +++VWL FHKKKW++Q   +      +   +   V R   ++ G  +G+ SF  R+ +SIL+  WQI+QI++T+ +G++R+W L+G ++H ++L++PR FYVN R+ KA  E   +++V+++LPRS +VY+LYEY++ E ++ +H ++I +E    ++EG+YE +VPLL R    LGC+C +++     + LS     +F L  L+ RS AQ  YL P SI+  +L+        + G F P   RA + +++  + N    Q   + + +S E    L     E L    P+H  FEV +     +  +AI + L+A++ E   PT IA +S   +  L S +P L+E+PLVPI + +  +++ VLDWQR   +  +++++  +  L++  E +RY HIP+GN+ +  + +       DLF+ R L ++N + W +  + PDLG KE  D  +++  +D     +  N  GCY T CV+L++    +NTI+  H V +++G +     SM +    I QA ++      +     ++   YD+       F+IL+++++ W+ ++  Y N  AD  +M FY+W+++  SL +DPAL ++L  +M+ +F +LI +   LG  VIY   N+I+LCTK+  + DA+ +VEY T ++ +++ F  L   +   W++L+W D SNY GIK     V+   H  +   + +              +   E+     E      +E NW++ ++L   +  Q   + I+  +++  +  +KD  + +       R    + +++EA       G+  +L P  +   +D++ NE+    + +  ++ K V    N+  L+                 P+LP  + +  +P ++ IK  C +L+LDT+    VN   R++ +L++   +S++A++R P  S               +PEVIC +CN  RDLDLC+D        +   W  +C  C  PYD + I+ TL++ ++    +  +QDL C KC  G+ ETS+        C     +T +     E+I I+ +I +HY + YL     W+LQ
Sbjct:   33 KRLERSQWTDKMDLRFGFERLKEPGEKTGWLINMHPTEILDEDKRLGSAVDYYFIQDDGSRFKVALPYKPYFYIATRKGCEREVSSFLSKKFQGKIAKVETVPKEDLDLPNHLVGLKRNYIRLSFHTVEDLVKVRKEISPAVKKNREQDHASDAYTALLSSVLQRGGVITDEEETSKKIADQLDNIVDMREYDVPYHIRLSIDLKIHVAHWYNVRYRGNA---FPVEITRRDDLVERPDPVVLAFDIETTKLPLKFPDAETDQIMMISYMIDGQGYLITNREIVSEDIEDFEFTPKPEYEGPFCVFNEPDEAHLIQRWFEHVQETKPTIMVTYNGDFFDWPFVEARAAVHGLSMQQEIGFQKDSQGEYKAPQCIHMDCLRWVKRDSYLPVGSHNLKAAAKAKLGYDPVELDPEDMCRMATEQPQTLATYSVSDAVATYYLYMKYVHPFIFALCTIIPMEPDEVLRKGSGTLCEALLMVQAFHANIIFPNKQEQEFNKLTDDGHVLDSETYVGGHVEALESGVFRSDIPCRFRMNPAAFDFLLQRVEKTLRHALEEEEKVPVEQVTNFEEVCDEIKSKLASLKDVPSRIECPLIYHLDVGAMYPNIILTNRLQPSAMVDEATCAACDFNKPGANCQRKMAWQWRGEFMPASRSEYHRIQHQLESEKFPPLFPEGPARAFHELSREEQAKYEKRRLADYCRKAYKKIHITKVEERLTTICQRENSFYVDTVRAFRDRRYEFKGLHKVWKKKLSAAV--EVGDAAEVKRCKNMEVLYDSLQLAHKCILNSFYGYVMRKGARWYSMEMAGIVCFTGANIITQARELIEQIGRPLELDTDGIWCVLPNSFPENFVFKTTNVKKPKVTISYPGAMLNIMVKEGFTNDQYQELAEPSSLTYVTRSENSIFFEVDGPYLAMILPASKEEGKKLKKRYAVFNEDGSLAELKGFEVKRRGELQLIKIFQSSVFEAFLKGSTLEEVYGSVAKVADYWLDVLYSKAANMPDSELFELISENRSMSRKLEDYGEQKSTSISTAKRLAEFLGDQMVKDAGLSCRYIISRKPEGSPVTERAIPLAIFQAEPTVRKHFLRKWLKSSSLQDFDIRAILDWDYYIERLGSAIQKIITIPAALQQVKNPVPRVKHPDWLHKKLLEKNDVYKQKKISELFTLEGRRQVTMAEASEDSPRPSAPDMEDFGLVKLPHPAAPVTVKRKR----VLWESQEESQDLTPTVPWQEILGQPPALGTSQEEWLVWLRFHKKKWQLQARQRLARRKRQRLESAEGVLRPGAIRDGPATGLGSFLRRTARSILDLPWQIVQISETSQAGLFRLWALVGSDLHCIRLSIPRVFYVNQRVAKAE-EGASYRKVNRVLPRSNMVYNLYEYSVPEDMYQEHINEINAELSAPDIEGVYETQVPLLFRALVHLGCVCVVNKQLV--RHLSGWEAETFALEHLEMRSLAQFSYLEPGSIRHIYLYHHAQAHKALFGIFIPSQRRASVFVLDTVRSN----QMPSLGALYSAEHGLLLEKVGPELLPP--PKHT-FEVRAETDLKTICRAIQRFLLAYKEERRGPTLIAVQSSWELKRLASEIPVLEEFPLVPICVADK-INYGVLDWQRHGARRMIRHYLNLDTCLSQAFEMSRYFHIPIGNLPEDISTF-----GSDLFFARHLQRHNHLLWLSPTARPDLGGKEADDNCLVMEFDD--QATVEINSSGCYSTVCVELDLQNLAVNTILQSHHVNDMEGAD-----SMGISFDVIQQASLEDMITGGQ---AASAPASYDETALCSNTFRILKSMVVGWVKEITQYHNIYADNQVMHFYRWLRSPSSLLHDPALHRTLHNMMKKLFLQLIAEFKRLGSSVIYANFNRIILCTKKRRVEDAIAYVEYITSSIHSKETFHSLTISFSRCWEFLLWMDPSNYGGIKG---KVSSRIHCGLQDSQKAGGAEDEQENEDDEEERDGEEEEEAEESNVEDLLENNWNILQFLPQAASCQNYFLMIVSAYIVAVYHCMKDGLRRSAPGSTPVRRRGASQLSQEAE------GAVGAL-PGMITFSQDYVANELTQSFFTITQKIQKKVTGSRNSTELSEMF--------------PVLPGSHLLLNNPALEFIKYVCKVLSLDTNITNQVNKLNRDLLRLVDVGEFSEEAQFRDPCRS-------------YVLPEVICRSCNFCRDLDLCKDSSFSEDGAVLPQW--LCSNCQAPYDSSAIEMTLVEVLQKKLMAFTLQDLVCLKC-RGVKETSMPVY---CSCAGDFALTIHTQVFMEQIGIFRNIAQHYGMSYLLETLEWLLQ 2279
[Close]
BLAST of DNA polymerase epsilon catalytic subunit vs. Ensembl Human
Match: POLE (DNA polymerase epsilon, catalytic subunit [Source:HGNC Symbol;Acc:HGNC:9177])

HSP 1 Score: 2090.08 bits (5414), Expect = 0.000e+0
Identity = 1077/2325 (46.32%), Postives = 1498/2325 (64.43%), Query Frame = 3 
Query:  102 EKILRLKKNDQIDLVYGFDLHSAIKIRTGWLINMKTTDAIDDNKRLVSAMSYYFLEEDGSKFKSTLIFQPYFYIVTKLGCESEIQTYLMKKYSACLHNIEIIEKEDLDLDNHXXXXXXXXXXXXXHTIDDLVRVRKEIMPKIKQNQKNQESDNDYSKMLTEHFQ--GEKKYEYNARKSALDIMDNAIDIREYDVPYHVRVSIDTAIFIGKWYDVHGSMNIKGPNSTHITPRSDIVDHPEPIVLAYDIETTKLPLKFPDATFDQIMMISYMIDGMGYLICNREIIADDIEDFEFTPRPEFPGPFSVFNEPNEKRTIERFFDHIREVKPNIFVTYNGDFFDWPFVETRAVKHGLDMLDYIGFSKDNQNEYKSRSAIHMDCFKWVQRDSYLPIGAQGLKAVCKAKLRYNPVEVDPEEMCKVAREDPRTLANYSVSDAVATYYLYMKYVHPFIFALCTIIPMDPDEVLRKGSGTLCECLLMVEAFNSNIIFPNKQESKLNPLTNDGHVIESETYVGGHVEAIESGVFRSDIPTKFKIVPEMCKFLRKNLKETLVHVLEVEEKVTVDSVLNFDEVYNAIDEKLEDLEETNIRFECPVIYHLDVAAMYPNIILSNRLQPSALVNEKTCGACDFNVPNAKCKRPMTWKWRGEIMPATKSEYYLIQNQLEKEKFPPKKPSLPMRSFYELDKLEQATVEKERLGKFCRNAYNRKHNTRFEERTAVVCQRENAFYVDTVRAFRDRRYQYKDLTKVSKKRLDELISSENGDASEIKRANGMLVLYDSLQLAHKCILNSFYGYVMRKGARWYSMEMAGIVCSTGAAIIKYAREMIEQIGRPLELDTDGIWCILPASFPQGFEFQTNNPKKRNISFSYPGAMLNLMVQQYFTNDQYHDLVDPAKHTYRIRSENSIFFEVDGPYLAMILPASKEMNKKLKKRYAVFNRDRSLAELKGFEVKRNGELNLIKIFQSSVFESFLKGSSISEVYQHVAIVANYWLDLLYSRASTMPDEELFELISEKRCMSKKLEEYGKQKSTSISTARRLAEFLGDEMVKDAGLSFKFIISKKPEGQQVTDRAIPVAIFQAEESVKRFYLSKWLKSKDLQDFDIRNILDWDYYINRFSSNIQKIITIPAALQEVPNPVPRVAHPDWLHKILMEKDNRFKQQRITDIF-----QTITPSQAAADKMK----DIENCAPISKKKPTGVTSLKRARNKDTVDVYGVQLDMDNLPN-HWRDILGDPVPKGNSKSQFIVWLEFHXXXXXXXXXXXDQSELSKENINPATVKRIKTVKKGIQSGISSFFTRSKQSILEDTWQIIQITDTNVSGIYRVWVLIGQEIHNMKLTVPRTFYVNTRIPKAPGENMYFKQVHKLLPRSRIVYHLYEYNLDETIFIKHRSDILSEFIRNEVEGIYELEVPLLLRVYAKLGCMCSIDRNHFTDQQLSN-NPSSFLLNELKFRSTAQHPYLSPNSIKTTFLFQQKSNRNEIIGWFDPCNNRAHLCLVEQSKPNPDKFQANVVQSWFSREREAFLSLKENESLISVVPEHVQFEVSSHKFEISAFKAINKLLVAHRNEVTTPTFIATKSKMTINELYSNLPALQEYPLVPITINETDVSFNVLDWQRIAIKSALQNFVKYEKLLAEMLERARYLHIPVGNMSKFTNDYRGISDSYDLFYGRFLMKNNFIWWCNDKSEPDLGKKENQDRRMMLVDNDVLNGMIYRNKPGCYPTTCVQLEMTYFPINTIIAMHKVMEIDGTNERLFESMIVPAKTIDQAMIQSKCNAAKRNLNLTSNTMYDDVTAAGPAFKILRNVILQWLDDVRNYKNPVADEHLMGFYKWMKNSRSLFYDPALFKSLQKLMRMVFFKLIEQLNNLGVEVIYGTLNKIVLCTKRTDLMDALVHVEYATKTVRNQDIFSQLDFQYVSGWDYLIWQDVSNYSGIKSDLESVTKEEHNSMVLEELSFVNMTNPSLSMGLSQSQNEDSFLTTEIADSSQIEMNWHLSRYLSPMSGVQLRLIEILQYFMLTNWKIVKDEYKLN-------RLAAKNDVAEEAVNTGTILGSDASLYPSSVQRMEDFLQNEMGYKLYLLVSQL-KDVPRMHNAVPLTTXXXXXXXXXXXSNKTPPLLPLKNKVSLHPIVDLIKTTCHILALDTSARYYVNDWKRNMFKLINFDAYSDQAKWRSPYSSDQSMGDAFRSDLIITVPEVICDNCNVTRDLDLCRDLY---QVRIKNSWWFVCPTCDFPYDRNVIQETLIDQVRCICESNVMQDLKCTKCTNGILETSLAGTENCVKCGNAIQVTQNAASLKEKIKIYADIGKHYDLPYLHMMTSWMLQ 7004
            +++ R +  D++DL +GF+       +TGWLINM                               L ++PYFYI T+ GCE E+ ++L KK+   +  +E + KEDLDL NHL+GLK+ +++L FHT++DLV+VRKEI P +K+N++   + + Y+ +L+   Q  G    E    K   D +DN +D+REYDVPYH+R+SID  I +  WY+V    N        IT R D+V+ P+P+VLA+DIETTKLPLKFPDA  DQIMMISYMIDG GYLI NREI+++DIEDFEFTP+PE+ GPF VFNEP+E   I+R+F+H++E KP I VTYNGDFFDWPFVE RA  HGL M   IGF KD+Q EYK+   IHMDC +WV+RDSYLP+G+  LKA  KAKL Y+PVE+DPE+MC++A E P+TLA YSVSDAVATYYLYMKYVHPFIFALCTIIPM+PDEVLRKGSGTLCE LLMV+AF++NIIFPNKQE + N LT+DGHV++SETYVGGHVEA+ESGVFRSDIP +F++ P    FL + +++TL H LE EEKV V+ V NF+EV + I  KL  L++   R ECP+IYHLDV AMYPNIIL+NRLQPSA+V+E TC ACDFN P A C+R M W+WRGE MPA++SEY+ IQ+QLE EKFPP  P  P R+F+EL + EQA  EK RL  +CR AY + H T+ EER   +CQREN+FYVDTVRAFRDRRY++K L KV KK+L   +  E GDA+E+KR   M VLYDSLQLAHKCILNSFYGYVMRKGARWYSMEMAGIVC TGA II  ARE+IEQIGRPLELDTDGIWC+LP SFP+ F F+T N KK  ++ SYPGAMLN+MV++ FTNDQY +L +P+  TY  RSENSIFFEVDGPYLAMILPASKE  KKLKKRYAVFN D SLAELKGFEVKR GEL LIKIFQSSVFE+FLKGS++ EVY  VA VA+YWLD+LYS+A+ MPD ELFELISE R MS+KLE+YG+QKSTSISTA+RLAEFLGD+MVKDAGLS ++IIS+KPEG  VT+RAIP+AIFQAE +V++ +L KWLKS  LQDFDIR ILDWDYYI R  S IQKIITIPAALQ+V NPVPRV HPDWLHK L+EK++ +KQ++I+++F     + +T ++A+ D  +    D+E+   +    P    ++KR R    V     +   D  P   W++ILG P   G S+ +++VWL FHKKKW++Q   +      +   +   V R   ++ G  +G+ SF  R+ +SIL+  WQI+QI++T+ +G++R+W L+G ++H ++L++PR FYVN R+ KA  E   +++V+++LPRS +VY+LYEY++ E ++ +H ++I +E    ++EG+YE +VPLL R    LGC+C +++     + LS     +F L  L+ RS AQ  YL P SI+  +L+        + G F P   RA + +++  + N    Q   + + +S E    L     E L    P+H  FEV +     +  +AI + L+A++ E   PT IA +S   +  L S +P L+E+PLVPI + +  +++ VLDWQR   +  +++++  +  L++  E +RY HIP+GN+ +  + +       DLF+ R L ++N + W +  + PDLG KE  D  +++  +D     +  N  GCY T CV+L++    +NTI+  H V +++G +     SM +    I QA ++      +     ++   YD+       F+IL+++++ W+ ++  Y N  AD  +M FY+W+++  SL +DPAL ++L  +M+ +F +LI +   LG  VIY   N+I+LCTK+  + DA+ +VEY T ++ +++ F  L   +   W++L+W D SNY GIK     V+   H  +   + +              +   E+     E      +E NW++ ++L   +  Q   + I+  +++  +  +KD  + +       R    + +++EA       G+  +L P  +   +D++ NE+    + +  ++ K V    N+  L+                 P+LP  + +  +P ++ IK  C +L+LDT+    VN   R++ +L++   +S++A++R P  S               +PEVIC +CN  RDLDLC+D        +   W  +C  C  PYD + I+ TL++ ++    +  +QDL C KC  G+ ETS+        C     +T +     E+I I+ +I +HY + YL     W+LQ
Sbjct:   33 KRLERSQWTDKMDLRFGFERLKEPGEKTGWLINMHPV---------------------------ALPYKPYFYIATRKGCEREVSSFLSKKFQGKIAKVETVPKEDLDLPNHLVGLKRNYIRLSFHTVEDLVKVRKEISPAVKKNREQDHASDAYTALLSSVLQRGGVITDEEETSKKIADQLDNIVDMREYDVPYHIRLSIDLKIHVAHWYNVRYRGNA---FPVEITRRDDLVERPDPVVLAFDIETTKLPLKFPDAETDQIMMISYMIDGQGYLITNREIVSEDIEDFEFTPKPEYEGPFCVFNEPDEAHLIQRWFEHVQETKPTIMVTYNGDFFDWPFVEARAAVHGLSMQQEIGFQKDSQGEYKAPQCIHMDCLRWVKRDSYLPVGSHNLKAAAKAKLGYDPVELDPEDMCRMATEQPQTLATYSVSDAVATYYLYMKYVHPFIFALCTIIPMEPDEVLRKGSGTLCEALLMVQAFHANIIFPNKQEQEFNKLTDDGHVLDSETYVGGHVEALESGVFRSDIPCRFRMNPAAFDFLLQRVEKTLRHALEEEEKVPVEQVTNFEEVCDEIKSKLASLKDVPSRIECPLIYHLDVGAMYPNIILTNRLQPSAMVDEATCAACDFNKPGANCQRKMAWQWRGEFMPASRSEYHRIQHQLESEKFPPLFPEGPARAFHELSREEQAKYEKRRLADYCRKAYKKIHITKVEERLTTICQRENSFYVDTVRAFRDRRYEFKGLHKVWKKKLSAAV--EVGDAAEVKRCKNMEVLYDSLQLAHKCILNSFYGYVMRKGARWYSMEMAGIVCFTGANIITQARELIEQIGRPLELDTDGIWCVLPNSFPENFVFKTTNVKKPKVTISYPGAMLNIMVKEGFTNDQYQELAEPSSLTYVTRSENSIFFEVDGPYLAMILPASKEEGKKLKKRYAVFNEDGSLAELKGFEVKRRGELQLIKIFQSSVFEAFLKGSTLEEVYGSVAKVADYWLDVLYSKAANMPDSELFELISENRSMSRKLEDYGEQKSTSISTAKRLAEFLGDQMVKDAGLSCRYIISRKPEGSPVTERAIPLAIFQAEPTVRKHFLRKWLKSSSLQDFDIRAILDWDYYIERLGSAIQKIITIPAALQQVKNPVPRVKHPDWLHKKLLEKNDVYKQKKISELFTLEGRRQVTMAEASEDSPRPSAPDMEDFGLVKLPHPAAPVTVKRKR----VLWESQEESQDLTPTVPWQEILGQPPALGTSQEEWLVWLRFHKKKWQLQARQRLARRKRQRLESAEGVLRPGAIRDGPATGLGSFLRRTARSILDLPWQIVQISETSQAGLFRLWALVGSDLHCIRLSIPRVFYVNQRVAKAE-EGASYRKVNRVLPRSNMVYNLYEYSVPEDMYQEHINEINAELSAPDIEGVYETQVPLLFRALVHLGCVCVVNKQLV--RHLSGWEAETFALEHLEMRSLAQFSYLEPGSIRHIYLYHHAQAHKALFGIFIPSQRRASVFVLDTVRSN----QMPSLGALYSAEHGLLLEKVGPELLPP--PKHT-FEVRAETDLKTICRAIQRFLLAYKEERRGPTLIAVQSSWELKRLASEIPVLEEFPLVPICVAD-KINYGVLDWQRHGARRMIRHYLNLDTCLSQAFEMSRYFHIPIGNLPEDISTF-----GSDLFFARHLQRHNHLLWLSPTARPDLGGKEADDNCLVMEFDD--QATVEINSSGCYSTVCVELDLQNLAVNTILQSHHVNDMEGAD-----SMGISFDVIQQASLEDMITGGQ---AASAPASYDETALCSNTFRILKSMVVGWVKEITQYHNIYADNQVMHFYRWLRSPSSLLHDPALHRTLHNMMKKLFLQLIAEFKRLGSSVIYANFNRIILCTKKRRVEDAIAYVEYITSSIHSKETFHSLTISFSRCWEFLLWMDPSNYGGIKG---KVSSRIHCGLQDSQKAGGAEDEQENEDDEEERDGEEEEEAEESNVEDLLENNWNILQFLPQAASCQNYFLMIVSAYIVAVYHCMKDGLRRSAPGSTPVRRRGASQLSQEAE------GAVGAL-PGMITFSQDYVANELTQSFFTITQKIQKKVTGSRNSTELSEMF--------------PVLPGSHLLLNNPALEFIKYVCKVLSLDTNITNQVNKLNRDLLRLVDVGEFSEEAQFRDPCRS-------------YVLPEVICRSCNFCRDLDLCKDSSFSEDGAVLPQW--LCSNCQAPYDSSAIEMTLVEVLQKKLMAFTLQDLVCLKC-RGVKETSMPVY---CSCAGDFALTIHTQVFMEQIGIFRNIAQHYGMSYLLETLEWLLQ 2252
[Close]
BLAST of DNA polymerase epsilon catalytic subunit vs. Ensembl Human
Match: POLE (DNA polymerase epsilon, catalytic subunit [Source:HGNC Symbol;Acc:HGNC:9177])

HSP 1 Score: 482.641 bits (1241), Expect = 8.930e-155
Identity = 231/296 (78.04%), Postives = 259/296 (87.50%), Query Frame = 3 
Query: 2403 MLVLYDSLQLAHKCILNSFYGYVMRKGARWYSMEMAGIVCSTGAAIIKYAREMIEQIGRPLELDTDGIWCILPASFPQGFEFQTNNPKKRNISFSYPGAMLNLMVQQYFTNDQYHDLVDPAKHTYRIRSENSIFFEVDGPYLAMILPASKEMNKKLKKRYAVFNRDRSLAELKGFEVKRNGELNLIKIFQSSVFESFLKGSSISEVYQHVAIVANYWLDLLYSRASTMPDEELFELISEKRCMSKKLEEYGKQKSTSISTARRLAEFLGDEMVKDAGLSFKFIISKKPEGQQVTDR 3290
            M VLYDSLQLAHKCILNSFYGYVMRKGARWYSMEMAGIVC TGA II  ARE+IEQIGRPLELDTDGIWC+LP SFP+ F F+T N KK  ++ SYPGAMLN+MV++ FTNDQY +L +P+  TY  RSENSIFFEVDGPYLAMILPASKE  KKLKKRYAVFN D SLAELKGFEVKR GEL LIKIFQSSVFE+FLKGS++ EVY  VA VA+YWLD+LYS+A+ MPD ELFELISE R MS+KLE+YG+QKSTSISTA+RLAEFLGD+MVKDAGLS ++IIS+KPEG  VT+R
Sbjct:    4 MEVLYDSLQLAHKCILNSFYGYVMRKGARWYSMEMAGIVCFTGANIITQARELIEQIGRPLELDTDGIWCVLPNSFPENFVFKTTNVKKPKVTISYPGAMLNIMVKEGFTNDQYQELAEPSSLTYVTRSENSIFFEVDGPYLAMILPASKEEGKKLKKRYAVFNEDGSLAELKGFEVKRRGELQLIKIFQSSVFEAFLKGSTLEEVYGSVAKVADYWLDVLYSKAANMPDSELFELISENRSMSRKLEDYGEQKSTSISTAKRLAEFLGDQMVKDAGLSCRYIISRKPEGSPVTER 299
[Close]
BLAST of DNA polymerase epsilon catalytic subunit vs. Ensembl Human
Match: POLE (DNA polymerase epsilon, catalytic subunit [Source:HGNC Symbol;Acc:HGNC:9177])

HSP 1 Score: 258.84 bits (660), Expect = 1.294e-76
Identity = 134/275 (48.73%), Postives = 191/275 (69.45%), Query Frame = 3 
Query:  102 EKILRLKKNDQIDLVYGFDLHSAIKIRTGWLINMKTTDAIDDNKRLVSAMSYYFLEEDGSKFKSTLIFQPYFYIVTKLGCESEIQTYLMKKYSACLHNIEIIEKEDLDLDNHXXXXXXXXXXXXXHTIDDLVRVRKEIMPKIKQNQKNQESDNDYSKMLTEHFQ--GEKKYEYNARKSALDIMDNAIDIREYDVPYHVRVSIDTAIFIGKWYDVHGSMNIKGPNSTHITPRSDIVDHPEPIVLAYDIETTKLPLKFPDATFDQIMMISYMIDGMG 920
            +++ R +  D++DL +GF+       +TGWLINM  T+ +D++KRL SA+ YYF+++DGS+FK  L ++PYFYI T+ GCE E+ ++L KK+   +  +E + KEDLDL NHL+GLK+ +++L FHT++DLV+VRKEI P +K+N++   + + Y+ +L+   Q  G    E    K   D +DN +D+REYDVPYH+R+SID  I +  WY+V    N        IT R D+V+ P+P+VLA+DIETTKLPLKFPDA  DQIMMISYMIDG G
Sbjct:   33 KRLERSQWTDKMDLRFGFERLKEPGEKTGWLINMHPTEILDEDKRLGSAVDYYFIQDDGSRFKVALPYKPYFYIATRKGCEREVSSFLSKKFQGKIAKVETVPKEDLDLPNHLVGLKRNYIRLSFHTVEDLVKVRKEISPAVKKNREQDHASDAYTALLSSVLQRGGVITDEEETSKKIADQLDNIVDMREYDVPYHIRLSIDLKIHVAHWYNVRYRGN---AFPVEITRRDDLVERPDPVVLAFDIETTKLPLKFPDAETDQIMMISYMIDGQG 304
[Close]
BLAST of DNA polymerase epsilon catalytic subunit vs. Ensembl Human
Match: POLE (DNA polymerase epsilon, catalytic subunit [Source:HGNC Symbol;Acc:HGNC:9177])

HSP 1 Score: 146.747 bits (369), Expect = 6.066e-39
Identity = 72/160 (45.00%), Postives = 117/160 (73.12%), Query Frame = 3 
Query:  102 EKILRLKKNDQIDLVYGFDLHSAIKIRTGWLINMKTTDAIDDNKRLVSAMSYYFLEEDGSKFKSTLIFQPYFYIVTKLGCESEIQTYLMKKYSACLHNIEIIEKEDLDLDNHXXXXXXXXXXXXXHTIDDLVRVRKEIMPKIKQNQKNQESDNDYSKMLT 581
            +++ R +  D++DL +GF+       +TGWLINM  T+ +D++KRL SA+ YYF+++DGS+FK  L ++PYFYI T+ GCE E+ ++L KK+   +  +E + KEDLDL NHL+GLK+ +++L FHT++DLV+VRKEI P +K+N++   + + Y+ +L+
Sbjct:   33 KRLERSQWTDKMDLRFGFERLKEPGEKTGWLINMHPTEILDEDKRLGSAVDYYFIQDDGSRFKVALPYKPYFYIATRKGCEREVSSFLSKKFQGKIAKVETVPKEDLDLPNHLVGLKRNYIRLSFHTVEDLVKVRKEISPAVKKNREQDHASDAYTALLS 192
[Close]
BLAST of DNA polymerase epsilon catalytic subunit vs. Ensembl Celegans
Match: pole-1 (DNA polymerase epsilon catalytic subunit [Source:UniProtKB/TrEMBL;Acc:O62218])

HSP 1 Score: 1504.19 bits (3893), Expect = 0.000e+0
Identity = 834/1965 (42.44%), Postives = 1179/1965 (60.00%), Query Frame = 3 
Query:   57 TEKENDVFEAIERN---EEKILRLKKNDQIDLVYGFDLHSAIKIRTGWLINMKTTDAIDD-NKRLVSAMSYYFLEEDGSKFKSTLIFQPYFYIVTKLGCESEIQTYLMKKYSACLHNIEIIEKEDLDLDNHXXXXXXXXXXXXXHTIDDLVRVRKEIMPKIKQNQKNQESDNDYSKMLTEHFQGEKKYEYNARKSALDIMDNAIDIREYDVPYHVRVSIDTAIFIGKWYDVHGSMNIKGPNSTHITPRSDI-VDHPEPIVLAYDIETTKLPLKFPDATFDQIMMISYMIDGMGYLICNREIIADDIEDFEFTPRPEFPGPFSVFNEPNEKRTIERFFDHIREVKPNIFVTYNGDFFDWPFVETRAVKHGLDMLDYIGFSKDNQNEYKSRSAIHMDCFKWVQRDSYLPIGAQGLKAVCKAKLRYNPVEVDPEEMCKVAREDPRTLANYSVSDAVATYYLYMKYVHPFIFALCTIIPMDPDEVLRKGSGTLCECLLMVEAFNSNIIFPNK----QESKLNPLTNDGHVIESETYVGGHVEAIESGVFRSDIPTKFKIVPEMCKFLRKNLKETLVHVLEVEEKVTVDSVLNFDEVYNAIDEKLEDLEETNIRFECPVIYHLDVAAMYPNIILSNRLQPSALVNEKTCGACDFNVPNAKCKRPMTWKWRGEIMPATKSEYYLIQNQLEKEKF--PPKKPSLPMRSFYELDKLEQATVEKERLGKFCRNAYNRKHNTRFEERTAVVCQRENAFYVDTVRAFRDRRYQYKDLTKVSKKRLDELISSENGDASEIKRANGMLVLYDSLQLAHKCILNSFYGYVMRKGARWYSMEMAGIVCSTGAAIIKYAREMIEQIGRPLELDTDGIWCILPASFPQGFEFQTNNPKKRNISFSYPGAMLNLMVQQYFTNDQYHDLVDPAKHTYRIRSENSIFFEVDGPYLAMILPASKEMNKKLKKRYAVFNRDRSLAELKGFEVKRNGELNLIKIFQSSVFESFLKGSSISEVYQHVAIVANYWLDLLYSRASTMPDEELFELISEKRCMSKKLEEYGKQKSTSISTARRLAEFLGDEMVKDAGLSFKFIISKKPEGQQVTDRAIPVAIFQAEESVKRFYLSKWLKSKDL-QDFDIRNILDWDYYINRFSSNIQKIITIPAALQEVPNPVPRVAHPDWLHKILMEKDNRFKQQRITDIFQTIT-PSQAAADKMK---------------DIENCAPISKKKPTGVTSLKRARNKDTVDVYGVQLDMDNLPNHWRDILGDPVPKGNSKSQFIVWLEFHXXXXXXXXXXXDQSELSKENINPATVKRIKTVKKGIQSGISSFFTRSKQSILEDTWQIIQITDTNVSGIYRVWVLIGQEIHNMKLTVPRTFYVNTRIPKAPGENMYFKQVHKLLPRSRIVYHLYEYNLDETIFIKHRSDILSEFIRNEVEGIYELEVPLLLRVYAKLGCMCSIDRNHFTDQQLSNNPSSFLLNELKFRSTAQHPYLSPNS-IKTTFLFQQKSNRNEIIGWFDPCNNRAHLCLVEQSK---PNPDKFQANVVQSWFSREREAFLSLKENESLISVVPEHVQFEVSSHKFEISAFKAINKLLVAHRNEVTTPTFIATKSKMTINELYSNLPALQEYPLVPITINETDVSFNVLDWQRIAIKSALQNFVKYEKLLAEMLERARYLHIPVGNMSKFTNDYRGISDSYDLFYGRFLMKNNFIWWCNDKSEPDLGKKENQDRRMMLVDNDV-LNGMIYRNKPGCYPTTCVQLEMTYFPINTIIAMHKVMEIDGTNERL-FESMIVPAKTIDQAMIQSKCNAAKRNLNLTSNTMYDDVTAAGPAFKILRNVILQWLDDVRNYKNPVADEHLMGFYKWMKNSRSLFYDPALFKSLQKLMRMVFFKLIEQLNNLGVEVIYGTLNKIVLCTKRTDLMDALVHVEYATKTVRNQDIFSQLDFQYVSGWDYLIWQDVSNYSGIK 5849
            + K++ + +A+E +   +E++  ++ ND+ID   GF  ++ ++ + G+LIN++ ++ +D+  K ++S + Y+F+ +   +FK +  F+PYFYI T  G E ++ +YL KKY A    +E +++EDLDL +HL GLKK ++KL F +  +L+++RKE+MP +++N    + ++ Y+  L  +  G K  +   ++   DI++  +DIREYDVP+H+RVSID  IF+G WYDV G     GPN      R D+ + H +P VLA+DIETTKLPLKFPD   D+IMMISYM+DG G+LI NREI++ DI  FE+TP+ E+ G F+V+NE +E   I +FFDH  +V+PNI VTYNGDFFDWPFVE RA   G +M   IGFSKD+ +EYKSR+ IHMD F+WV+RDSYLP+G+Q LKAV KAKLRY+PVEV+PE MCK+ARE P+ LANYSVSDAV+TYYLYMKYVH FIFALCTIIP+  D+VLRKGSGTLCE LLMVEAF++NI+FPNK    +E++    + DGH +ESETYVGGHVEA+E+GVFR+DIP KF++     + L+  ++ETL   L  E +VT+D V++FDE    + +  + +     R E P IYHLDV AMYPNIIL+NRLQP A+V E+ C  C +N P+A+CKR M W+WRGE+ PAT+ EY  I  QLE E F  PPK        F+ L++ E+  +E +R+  + R  Y + H TR E R   +CQREN FYV+TV+AFRDRRY+YKD+ K +K R D+  +    D + +  +   +VLY+SLQLAHKCILNSFYGYVMRKG+RW+SMEMAGIVC TGA II+ AR+++EQIG PLELDTDGIWC++PASFP+   F+  N K+ +++ SYPGAMLN +V + FTN QYH L      +Y   SENSI+FEVDGPY  MILPASKE  KKLKKRYAVFN D SLAE+KGFE+KR GELN+IK FQ  VF++FL G ++ E Y+ VA  A++WLD+L+S  + + DEELF+LISE R MS+KLE+YG QKSTSISTA+RLAEFLGD+MVKDAGL+  FIISK P G  VT+RAIPVAIF+++  V+  Y+ KW K  D  +D DIR++LDWDYY+ RF S IQKIITIPAALQ + NPVPRV HPDWL   +  K +  +Q RI  IF     PS +  D  K               D ++   I   K  G    KR +N   V    V L+   L  H                 F  W+ F KKKW++      Q +  K  ++      ++ + +G           ++++  +  W I+ +  T  +  + VW+ +  ++H + + + R   V++R P+   +      + ++LP  +    LYE+  DE         + SE   + ++GIYE EVP   R   +LG   SI R    D  +S       L  LK    A  PYL  +  I+T FL++   +   +    D   + A+  +V       PN D    +      S ER       E+          + F V          + + + L  +R   +    +   S      L   LP L  +P V + I E     N +DWQ++  +  LQ++      LA+ LE ARYL +P+GN+      +       DL + R L K+    W    S PDLG KE  D R+ +  N + ++  +  N+     T CV+L+++   +  ++   +V+E +G ++ + F+SM     TI Q   QS    A     + S   YD+  A     K+L+ ++ + +  + +  N  ADE +M   +W+    +L +D AL +S+  L   +   L  +   +G +VI+ T  K+VL T ++   +A    E   +++    +F+ L    V  +D ++W D  N++GI+
Sbjct:    2 SSKDDILAQAVENDSNYKERLALIRSNDEIDAKLGFSRYTGLQEKKGFLINIQPSELVDEQTKVIISVVDYFFISDMDERFKISYPFRPYFYIATLDGFEFQVSSYLSKKYGA-QTAVEHMDREDLDLKDHLSGLKKTYIKLSFTSTVELIKIRKELMPLVRKNTDRIKKESAYADYLARNLSG-KGGDSKDQQLNGDILNQIVDIREYDVPFHMRVSIDEKIFVGLWYDVKGI----GPNRVPTIKRKDLPLFHAKPKVLAFDIETTKLPLKFPDRESDEIMMISYMVDGRGFLIINREIVSADINAFEYTPKAEYIGEFTVWNEKDEAALIRKFFDHFLQVRPNIVVTYNGDFFDWPFVEARAKIRGFNMEREIGFSKDSADEYKSRNCIHMDAFRWVKRDSYLPVGSQNLKAVTKAKLRYDPVEVEPELMCKMAREQPQQLANYSVSDAVSTYYLYMKYVHQFIFALCTIIPLGADDVLRKGSGTLCEALLMVEAFHNNIVFPNKYTGPEETR---FSKDGHRVESETYVGGHVEALEAGVFRADIPAKFRLSVPALEQLKSEIQETLRKELAREFEVTLDQVVDFDEQCAEVQDAFDGMINVPTRLENPRIYHLDVGAMYPNIILTNRLQPCAMVTEEICMGCSYNKPDAECKRTMAWEWRGELTPATRGEYQQIMQQLEAESFGKPPKH-------FHMLERSEREAIEMKRIKDYSRRVYGKTHLTRLEMRETTICQRENHFYVETVKAFRDRRYEYKDMLKKAKGRFDQ--AQATNDLATMTTSKLEMVLYESLQLAHKCILNSFYGYVMRKGSRWFSMEMAGIVCHTGANIIREARKLVEQIGTPLELDTDGIWCLIPASFPENVTFKLKNHKRSSVTVSYPGAMLNALVYEGFTNHQYHTLEKDG--SYSKSSENSIYFEVDGPYQCMILPASKEEGKKLKKRYAVFNLDGSLAEMKGFELKRRGELNIIKHFQGCVFKTFLNGKTLEETYKAVAADADHWLDILHSHGADLTDEELFDLISENRSMSRKLEDYGAQKSTSISTAKRLAEFLGDDMVKDAGLACMFIISKHPIGAPVTERAIPVAIFKSDAKVRSHYIRKWTKQVDFNEDTDIRDMLDWDYYLERFGSCIQKIITIPAALQGISNPVPRVPHPDWLQNKIRNKFDAHRQPRINQIFAACQKPSTSQMDNGKRRRTPDDDVASEDAMDSQDDIIIDDDKENGA---KRQKNTKKVHTTEVVLEKKTLVEH----------------GFDEWMGFLKKKWRV------QRKERKTQLSSKDSDVVEAIVRG-----------AREAEHDKEWHILSVEPTADASFFNVWLAVQGQMHKVIMKIGRRIIVDSRAPRGDRDT-----IRRILPHHKTPGFLYEFRTDENQLTALMDKLYSETCSSTIDGIYESEVPTSFRAVLQLG---SIVR---PDHGISLGGHQLTLENLKPMEKA--PYLPLDQKIRTIFLYKFSQDSRHVYSLIDSSGSAAYFYIVNTGDVQMPNMDSLYTSAYTKMMSTERGQLCHTSES----------MPFTVKRFSSNTECERQLGRALRVYREVSSKTAIVLLLSDTDPFRLARKLPNLGLFPNVQLHITEPSSLLNQIDWQKVVARRVLQHYFNSFFFLADYLEWARYLRVPIGNLPADHALF-----GLDLLFARNLQKSGHALWATRASRPDLGGKEMDDVRLSVDWNPLSIDDTVLLNRETFCETACVELQLSAVAVTALVQRSRVLEAEGADDVVTFDSM----NTIAQ---QSVTGGA-----VNSIACYDEGAAVDATIKVLKQMLTECVRHIAHQGNARADEVVMTVSRWLNTRSALLFDAALTRSVSVLESKLVLLLCAECERIGAKVIHATAQKLVLNTGKSTSEEAKGFAEMLIQSLSTNVVFAALHITPVKFFDAMLWMDAHNHTGIR 1870
[Close]
BLAST of DNA polymerase epsilon catalytic subunit vs. Ensembl Fly
Match: DNApol-epsilon255 (gene:FBgn0264326 transcript:FBtr0084408)

HSP 1 Score: 1843.55 bits (4774), Expect = 0.000e+0
Identity = 941/2023 (46.52%), Postives = 1323/2023 (65.40%), Query Frame = 3 
Query:   96 NEEKILRLKKNDQIDLVYGFDLHSAIKIRTGWLINMKTTDAIDDNKRLVSAMSYYFLEEDGSKFKSTLIFQPYFYIVTKLGCESEIQTYLMKKYSACLHNIEIIEKEDLDLDNHXXXXXXXXXXXXXHTIDDLVRVRKEIMPKIKQNQKNQESDNDYSKMLTEHFQGEKKYEYNAR--KSALDIMDNAIDIREYDVPYHVRVSIDTAIFIGKWYDVHGSMNIKGPNSTHITPRSDIVDHPEPIVLAYDIETTKLPLKFPDATFDQIMMISYMIDGMGYLICNREIIADDIEDFEFTPRPEFPGPFSVFNEPNEKRTIERFFDHIREVKPNIFVTYNGDFFDWPFVETRAVKHGLDMLDYIGFSKDNQNEYKSRSAIHMDCFKWVQRDSYLPIGAQGLKAVCKAKLRYNPVEVDPEEMCKVAREDPRTLANYSVSDAVATYYLYMKYVHPFIFALCTIIPMDPDEVLRKGSGTLCECLLMVEAFNSNIIFPNKQESKLNPLTNDGHVIESETYVGGHVEAIESGVFRSDIPTKFKIVPEMCKFLRKNLKETLVHVLEVEEKVTVDSVLNFDEVYNAIDEKLEDLEETNIRFECPVIYHLDVAAMYPNIILSNRLQPSALVNEKTCGACDFNVPNAKCKRPMTWKWRGEIMPATKSEYYLIQNQLEKEKFPPKKPSLPMRSFYELDKLEQATVEKERLGKFCRNAYNRKHNTRFEERTAVVCQRENAFYVDTVRAFRDRRYQYKDLTKVSKKRLDELISSENGDASEIKRANGMLVLYDSLQLAHKCILNSFYGYVMRKGARWYSMEMAGIVCSTGAAIIKYAREMIEQIGRPLELDTDGIWCILPASFPQGFEFQTNNPKKRNISFSYPGAMLNLMVQQYFTNDQYHDLVDPAKHT---YRIRSENSIFFEVDGPYLAMILPASKEMNKKLKKRYAVFNRDRSLAELKGFEVKRNGELNLIKIFQSSVFESFLKGSSISEVYQHVAIVANYWLDLLYSRASTMPDEELFELISEKRCMSKKLEEYGKQKSTSISTARRLAEFLGDEMVKDAGLSFKFIISKKPEGQQVTDRAIPVAIFQAEESVKRFYLSKWLKSKDLQDFDIRNILDWDYYINRFSSNIQKIITIPAALQEVPNPVPRVAHPDWLHKILMEKDNRFKQQRITDIFQT---ITPSQAAADKMKDIENCAPISKKKPTGVTSLKRARNKDTVDVYGVQLDMDNLPNH--WRDILGDPVPKGNSKSQFIVWLEFHXXXXXXXXXXXDQSELSKENI---NPATVKRIKTVKKGIQSGISSFFTRSKQSILEDTWQIIQITDTNVSGIYRVWVLIGQEIHNMKLTVPRTFYVNTRIPKAPGENMYFKQVHKLLPRSRIVYHLYEYNLDETIFIKHRSDILSEFIRNEVEGIYELEVPLLLRVYAKLGCMCSIDRNHFT--DQQLSNNPSSFLLNELKFRSTAQHPYLSP--NSIKTTFLFQQK--SNRNEIIGWFDPCNNRAHLCLVEQSKPNPDKFQANVVQSWFSREREAFLSLKENESLISVVPEHVQFEVSSHKFEISAFKAINKLLVAHRNEVTTPTFIATKSKMTINELYSNLPALQEYPLVPITINETDVSFNVLDWQRIAIKSALQNFVKYEKLLAEMLERARYLHIPVGNMSKFTNDYRGISDSYDLFYGRFLMKNNFIWWCNDKSEPDLGKKENQDRRMMLVDNDVLNGMIYRNKPGCYPTTCVQLEMTYFPINTIIAMHKVMEIDGTNERLFESMIVPAKTIDQAMIQSKCNAAKRNLNLTSNTMYDDVTAAGPAFKILRNVILQWLDDVRNYKNPVADEHLMGFYKWMKNSRSLFYDPALFKSLQKLMRMVFFKLIEQLNNLGVEVIYGTLNKIVLCTKRTDLMDALVHVEYATKTVRNQDIFSQLDFQYVSGWDYLIWQDVSNYSGIKSDL-----ESVTKEEHNSMVLEELSFVNMTNPSLSMGLSQSQNEDSFLTTEIADSSQIEMNWHLSRYLSPMSGVQLRLIEILQYFM 6092
            NE    + ++ND+ID  YGFD     + RTG+LINM + + +D+++RL++A+  +F++ DGS+FK T+ +QPY  I  +     E+  +L +KYS  +  +E I KEDLDL NHL GL++ ++KL F     + +VR+E+M  +K+NQ+ Q+S+  Y +ML            +A   K   D MD  +DIRE+DVPYHVRVSID  IF G+WY++     ++ P    IT R DI+D PEP+VLA+DIETTKLPLKFPDA  DQ+MMISYMIDG GYLI NREII+ +++DFE+TP+PEF G F VFNE NE + ++RFFDHI EV+P+I VTYNGDFFDWPFVETRA  + LDM   IGFSK     Y SR AIHMDC  WV+RDSYLP+G+QGLKAV KAKLRY+PVE+DPE+MC++A E P+ LANYSVSDAVATYYLYMKYVHPFIFAL TIIPM+PDE+LRKGSGTLCE LLMVEA+++ I++PNK +S+LN L+N+GHV++SETYVGGHVEA+ESGVFR+DIP +F++ P M K L++ +   L H +EVEE + ++ VLN DEV   I + L+ L +   R E PVIYHLDV AMYPNIIL+NRLQPSA+V++  C ACDFN P  +CKR M W WRGE++PA+++E+  IQ QLE EKFPP  P  P R+F+EL K +QA  EK+RL  +CR AY +   T+ E RT+ +CQ+EN+FYVDTVRAFRDRRY+YK LTKV+K  ++  ++S  GDA+EIK A G  VLYDSLQLAHKCILNSFYGYVMR+GARW+SM MAGIVC TG+ II  ARE+IE++GRPLELDTDGIWCILP SFPQ F   T++ KK+ I+ SYP A+LN MV+ +FTNDQYH+L    ++    Y IR ENSIFFEVDGPYLAM+LPA+KE  KKLKKRYAVFN D +LAELKGFEVKR GEL LIK FQSSVFE+FL GS++ E Y  VA VA+YWLD+LYSR S +PD ELFELISE + MSKKLEEYG QKSTSISTA+RLAEFLG++MVKDAGL+ K+IISKKPEG  VT+RAIP+AIFQ+E SV+R +L +WLK   + D DIR++LDW+YYI R    IQKIITIPAALQ + NPVPRV HPDWLHK ++EK++  KQ+RI ++F +     P     DK+ D+E+ A     +      +   R +  ++ +    D +  P    WR  LG P P G ++   + W+ F KKKWK Q+  + ++  + +     +P  V+       G  + +  F  R+++++L+  WQI+Q+   +  G + VW LIG+E+H +KLTVPR FYVN R    P E   +++V+++LPRSR V++LY Y++ E +F  +   +L++    ++EGIYE ++ L  R    +GC+C + R       Q  + +  +F + +L+ R   Q  YL+   N ++  +L+Q    + + EI       + +A +  ++  + N    Q   ++  ++ ER A L     E    +  E   FEV         ++ I + L  ++ E   PT +  ++ ++  +L   +P L E+P   I I++     + LDWQR   ++ +++F+    +L  ML++ RY H+P+GNM   T     +    DLF+ R L ++NF+ W +  + PDLG +E  D R++    + ++  + +NK G YP  CV+L +    ++ ++   ++ E++G +          A T D  M Q         +   +   YD+      AF+++R+++  WL +V   +N  +D  ++ FY+W+++S +L YDPAL +SL  LMR +F ++I +   LG  +IY   N+I+L + +  + DAL +V+Y  +++RN+++F  +   +   W++++W D +N+SGI+  L     E+V+     +M+ +     +          ++   E +    +  D   +E+NW +  +L   +  + +   +L  FM
Sbjct:   29 NEAGYRQSRENDKIDSKYGFDRVKDSQERTGYLINMHSNEVLDEDRRLIAALDLFFIQMDGSRFKCTVAYQPYLLIRPEDNMHLEVARFLGRKYSGQISGLEHITKEDLDLPNHLSGLQQQYIKLSFLNQTAMTKVRRELMSAVKRNQERQKSNTYYMQMLATSLAQSSAGSEDATLGKRQQDYMDCIVDIREHDVPYHVRVSIDLRIFCGQWYNIRCRSGVELPT---ITCRPDILDRPEPVVLAFDIETTKLPLKFPDAQTDQVMMISYMIDGQGYLITNREIISSNVDDFEYTPKPEFEGNFIVFNEENEMQLLQRFFDHIMEVRPHIIVTYNGDFFDWPFVETRAAVYDLDMKQEIGFSKLRDGNYLSRPAIHMDCLCWVKRDSYLPVGSQGLKAVAKAKLRYDPVELDPEDMCRMAVEQPQVLANYSVSDAVATYYLYMKYVHPFIFALNTIIPMEPDEILRKGSGTLCETLLMVEAYHAQIVYPNKHQSELNKLSNEGHVLDSETYVGGHVEALESGVFRADIPCRFRLDPAMVKQLQEQVDAVLRHAIEVEEGIPLEKVLNLDEVRQEIVQGLQGLHDIPNRLEQPVIYHLDVGAMYPNIILTNRLQPSAMVSDLDCAACDFNKPGVRCKRSMDWLWRGEMLPASRNEFQRIQQQLETEKFPPLFPGGPQRAFHELSKEDQAAYEKKRLTDYCRKAYKKTKLTKLETRTSTICQKENSFYVDTVRAFRDRRYEYKGLTKVAKASVNAAVAS--GDAAEIKAAKGREVLYDSLQLAHKCILNSFYGYVMRRGARWHSMPMAGIVCLTGSNIITKAREIIERVGRPLELDTDGIWCILPGSFPQEFTIHTSHEKKKKINISYPNAVLNTMVKDHFTNDQYHELRKDKENNLPKYDIRDENSIFFEVDGPYLAMVLPAAKEEGKKLKKRYAVFNFDGTLAELKGFEVKRRGELQLIKNFQSSVFEAFLAGSTLEECYASVAKVADYWLDVLYSRGSNLPDSELFELISENKSMSKKLEEYGAQKSTSISTAKRLAEFLGEQMVKDAGLACKYIISKKPEGAPVTERAIPLAIFQSEPSVRRHHLRRWLKDNTMGDADIRDVLDWNYYIERLGGTIQKIITIPAALQGLANPVPRVQHPDWLHKKMLEKNDVLKQRRINEMFTSRPKPKPLATEEDKLADMEDLAGKDGGEGAAGCPIVTKRKRIQLEEHD---DEEAQPQATTWRQALGAPPPIGETRKTIVEWVRFQKKKWKWQQDQRQRNRQASKRTRGEDPPVVR-----ATGSTATLGGFLRRAQRTLLDQPWQIVQLVPVDDLGHFTVWALIGEELHKIKLTVPRIFYVNQRSAAPPEEGQLWRKVNRVLPRSRPVFNLYRYSVPEQLFRDNSLGMLADLATPDIEGIYETQMTLEFRALMDMGCICGVQREEARRLAQLATKDLETFSIEQLEQRPQTQVKYLASANNRLRKIYLYQHNTPTAKKEIWSLILMPSKKAFVFALDTVRAN----QMPNMRQLYTAERLALLKNLTAEEQDKIPVEDYTFEVLIEVDVKQIYRHIQRALTTYKQEHQGPTILCLQTALSARKLSLAMPILLEFPQAEIHISDDASLLSGLDWQRQGSRAVIRHFLNLNNVLDLMLDQCRYFHVPIGNMPPDT-----VLFGADLFFARLLQRHNFVLWWSASTRPDLGGREADDSRLLAEFEESIS--VVQNKAGFYPDVCVELALDSLAVSALLQSTRIQEMEGASS---------AITFD-VMPQVSLEEMIGTVPAATLPSYDETALCSAAFRVMRSMVNGWLREVSINRNIFSDFQIVHFYRWVRSSNALLYDPALRRSLNNLMRKMFLRIIAEFKRLGATIIYADFNRIILSSGKKTVSDALGYVDYIVQSLRNKEMFHSIQLSFEQCWNFMLWMDQANFSGIRGKLPKGIDETVSSIVSTTMIRDSERNQDDDEDEEEDSENRDPVESNEAEQDQEDELSLELNWTIGEHLPDENECREKFESLLTLFM 2017

HSP 2 Score: 88.5817 bits (218), Expect = 7.770e-17
Identity = 50/159 (31.45%), Postives = 81/159 (50.94%), Query Frame = 3 
Query: 6417 PIVDLIKTTCHILALDTSARYYVNDWKRNMFKLINFDAYSDQAKWRSPYSSDQSMGDAFRSDLIITVPEVICDNCNVTRDLDLCRDLYQVRIKNSWWFVCPTCDFPYDRNVIQETLIDQVRCICESNVMQDLKCTKCTNGILETSLAGTENCVKCGNAI 6893
            P ++LI+T    L++D +    +N+ +RNM +L+    +SD A+W  P  S               + EVIC  CN  RDLDLC+D ++        ++C  C   YD   I+  ++D ++    S V+QDL+C++C+  I   +LA  E C   GN +
Sbjct: 2055 PGLELIRTLIKALSVDKTLAEQINELRRNMLRLVGIGEFSDLAEWEDPCDSH-------------IINEVICKACNHCRDLDLCKDKHRAMKDGVPVWLCAQCYVAYDNEEIEMRMLDALQRKMMSYVLQDLRCSRCSE-IKRENLA--EFCTCAGNFV 2197
[Close]
BLAST of DNA polymerase epsilon catalytic subunit vs. Ensembl Zebrafish
Match: pole (polymerase (DNA directed), epsilon [Source:ZFIN;Acc:ZDB-GENE-070705-557])

HSP 1 Score: 2111.26 bits (5469), Expect = 0.000e+0
Identity = 1073/2313 (46.39%), Postives = 1509/2313 (65.24%), Query Frame = 3 
Query:  102 EKILRLKKNDQIDLVYGFDLHSAIKIRTGWLINMKTTDAIDDNKRLVSAMSYYFLEEDGSKFKSTLIFQPYFYIVTKLGCESEIQTYLMKKYSACLHNIEIIEKEDLDLDNHXXXXXXXXXXXXXHTIDDLVRVRKEIMPKIKQNQKNQESDNDYSKMLTEHFQGEK---KYEYNARKSALDIMDNAIDIREYDVPYHVRVSIDTAIFIGKWYDVHGSMNIKGPNSTHITPRSDIVDHPEPIVLAYDIETTKLPLKFPDATFDQIMMISYMIDGMGYLICNREIIADDIEDFEFTPRPEFPGPFSVFNEPNEKRTIERFFDHIREVKPNIFVTYNGDFFDWPFVETRAVKHGLDMLDYIGFSKDNQNEYKSRSAIHMDCFKWVQRDSYLPIGAQGLKAVCKAKLRYNPVEVDPEEMCKVAREDPRTLANYSVSDAVATYYLYMKYVHPFIFALCTIIPMDPDEVLRKGSGTLCECLLMVEAFNSNIIFPNKQESKLNPLTNDGHVIESETYVGGHVEAIESGVFRSDIPTKFKIVPEMCKFLRKNLKETLVHVLEVEEKVTVDSVLNFDEVYNAIDEKLEDLEETNIRFECPVIYHLDVAAMYPNIILSNRLQPSALVNEKTCGACDFNVPNAKCKRPMTWKWRGEIMPATKSEYYLIQNQLEKEKFPPKKPSLPMRSFYELDKLEQATVEKERLGKFCRNAYNRKHNTRFEERTAVVCQRENAFYVDTVRAFRDRRYQYKDLTKVSKKRLDELISSENGDASEIKRANGMLVLYDSLQLAHKCILNSFYGYVMRKGARWYSMEMAGIVCSTGAAIIKYAREMIEQIGRPLELDTDGIWCILPASFPQGFEFQTNNPKKRNISFSYPGAMLNLMVQQYFTNDQYHDLVDPAKHTYRIRSENSIFFEVDGPYLAMILPASKEMNKKLKKRYAVFNRDRSLAELKGFEVKRNGELNLIKIFQSSVFESFLKGSSISEVYQHVAIVANYWLDLLYSRASTMPDEELFELISEKRCMSKKLEEYGKQKSTSISTARRLAEFLGDEMVKDAGLSFKFIISKKPEGQQVTDRAIPVAIFQAEESVKRFYLSKWLKSKDLQDFDIRNILDWDYYINRFSSNIQKIITIPAALQEVPNPVPRVAHPDWLHKILMEKDNRFKQQRITDIFQT-----ITPSQAAADKMKDIEN-CAPISKKKPTGVTSLKRARNKDTVDVYGVQLDMDNLPNHWRDILGDPVPKGNSKSQFIVWLEFHXXXXXXXXXXXDQSELSKENINPATVKRIKTV-KKGIQSGISSFFTRSKQSILEDTWQIIQITDTNVSGIYRVWVLIGQEIHNMKLTVPRTFYVNTRIPKAPGENMYFKQVHKLLPRSRIVYHLYEYNLDETIFIKHRSDILSEFIRNEVEGIYELEVPLLLRVYAKLGCMCSIDRNHFTDQQLSNNPSSFLLNELKFRSTAQHPYLSPNSIKTTFLFQQKSNRNEIIGWFDPCNNRAHLCLVEQSKPNPDKFQANVVQSWFSREREAFLSLKENESLISVVPEHVQFEVSSHKFEISAFKAINKLLVAHRNEVTTPTFIATKSKMTINELYSNLPALQEYPLVPITINETDVSFNVLDWQRIAIKSALQNFVKYEKLLAEMLERARYLHIPVGNMSKFTNDYRGISDSYDLFYGRFLMKNNFIWWCNDKSEPDLGKKENQDRRMMLVDNDVLNGMIYRNKPGCYPTTCVQLEMTYFPINTIIAMHKVMEIDGTNERLFESMIVPAKTIDQAMIQSKCNAAKRNLNLTSNTMYDDVTAAGPAFKILRNVILQWLDDVRNYKNPVADEHLMGFYKWMKNSRSLFYDPALFKSLQKLMRMVFFKLIEQLNNLGVEVIYGTLNKIVLCTKRTDLMDALVHVEYATKTVRNQDIFSQLDFQYVSGWDYLIWQDVSNYSGIKSDL-ESVTKEEHNSMVLEELSFVNMTNPSLSMGLSQSQNEDSFLTTEIADSSQIEMNWHLSRYLSPMSGVQLRLIEILQYFMLTNWKIVKDEYKLNRLAAKNDVAEEAVNTGTILGSDASLYPSSVQRMEDFLQNEMGYKLYLLVSQLKDVPRMHNAVPLTTXXXXXXXXXXXSNKTPPLLPLKNKVSLHPIVDLIKTTCHILALDTSARYYVNDWKRNMFKLINFDAYSDQAKWRSPYSSDQSMGDAFRSDLIITVPEVICDNCNVTRDLDLCRD--LYQVRIKNSWWFVCPTCDFPYDRNVIQETLIDQVRCICESNVMQDLKCTKCTNGILETSLAGTENCVKCGNAIQVTQNAASLKEKIKIYADIGKHYDLPYLHMMTSWML 7001
            +++ R +  D +D  +GF+       +TGWLINM  T+ +DD+KR++SA+ YYF++EDG++FK  L ++PYFYI TK   E E+ ++L KK+   +  +E + KEDLDL NHL+GLK+ ++KL F+T+DDL++V++EI P +++N++ ++S++ Y+ ML+    G     + E  + K   + +DN +D+REYDVPYHVRVSID  I +  WY+V    +   P    I  R D+V+ P+P+VLA+DIETTKLPLKFPDA  DQIMMISYMIDG G+LI NREI+++DIEDFEFTP+PE+ GPF++FNEP+E   I+R+F+H+ E KPNIFVTYNGDFFDWPFVE RA + GL M   IGF KDNQ EYK+  AIHMDC +WV+RDSYLP+G+  LKA  KAKL Y+PVE+DPEEMC++A E+P+TLA YSVSDAVATYYLYMKYVHPFIFALCTIIPM+PDEVLRKGSGTLCE LLMV+A++ NI+FPNKQE   N LT+DGHV++SETYVGGHVEA+ESGVFRSDIP +FK+ P    FL + ++ TL H +E EEK+ ++ V NF+EV + I  KL  L+E   R ECP+IYHLDV AMYPNIIL+NRLQPSA+V+E TC ACDFN P A C+R MTW+WRGEIMPA++SE++ IQ QLE EKFPP  P+ P R+F+EL++ EQA  EK+RLG +CR AY + H TR EER   +CQREN+FYVDTVRAFRDRRY++K L KV KK+L    + +NGDA+E+KR   M +LY+SLQLAHKCILNSFYGYVMRKGARWYSMEMAGIVC TGA II  ARE+IEQIGRPLELDTDGIWC+LP +FP+ F  ++ N KK  ++ SYPGAMLN+MV++ FTN QY +LVD A  TY  R+ENSIFFEVDGPYLAMILPASKE  KKLKKRYAVFN D SLAELKGFEVKR GEL LIKIFQSSVFE+FLKG+++ EVY  VA VA+YWLD+LYS+A+ MPD ELFELISE R MS+KLE+YG+QKSTSISTA+RLAEFLGD+MVKDAGLS +++IS+KPEG  VT+RAIP+AIFQAEESVK+ +L KWLK   L D DIR+ILDW YYI R  S IQKIITIPAALQ+V NPVPRV HPDWLHK L+EK++ +KQ++I+++F +     +     AA +  D+E+  AP    +P  + S KR R     D    +     L   WR+ILG P   G ++ + +VWL +HKKKW++Q   + +    +  I+  +      V + G  +G+ SF  R+ +SIL+  WQI+QI +T+  G+Y++W +IG ++H MKL +PR FYVN R+PK   E    K+V+++LPRS +   LY+Y + E ++ +H ++I ++    ++EG+YE +VPLL R   +LGCMC +++ H           +F L  L+ RS AQ  YL P S++  +L+        + G F P   +A + +++  + N    Q   + S +  ER A L  K  E L+   PE   FEV +     + ++A+ ++L+ ++ E   PT IA +S   +  L + +  L+E+P+VP+ + + ++S+NVLDWQR   +  +++++  +  L++  + ARY H+PVGN+ +  + +       DLF  R L K+N + W +  + PDLG KE  D R+++  ++   G +  N  GCY T CV+L++    +NTI+    V +++G       S+ V    I  A ++   +    N    +   YD+       F+IL+++++ W+ ++  Y N  AD  +M FY+W+++  SL YDPAL ++L  +M+ +F +L+ +   LG  VIYG  N+++LCTK+  + DA+ +VEY T ++  ++IF  L   +   W++L+W D +N  G+K  L  S+   EH+S   ++                ++Q ED     E      IE NW++ +YL   +  Q   + I+  ++   +  ++ E + N   A       A         D S  P  +   ++++ +E+    + +  +++       +V L ++               P+LP  +    +P ++ IK  C +L+LD +    VN  KR++ +L++   +S+ A++R P  S               +PEVIC +CN  RDLDLC+D  + Q       WF C  C   YD   I+  L++ ++    S  +QD++C KC  G+ E ++        C     +T    S  E+++++ +I  HY++ +L     W++
Sbjct:   31 KRLERSQFTDSMDERFGFERMKEPGEKTGWLINMHPTEILDDDKRMISAVDYYFIQEDGNRFKVALPYKPYFYIATKKNTEREVISFLSKKFQGKVAKLESVPKEDLDLPNHLVGLKRNYIKLSFNTVDDLIKVKREISPAVRKNREREKSNDAYTSMLSSALVGGSVVTEDEGGSSKKMTEQLDNILDMREYDVPYHVRVSIDLKIHVAHWYNVRYRGSAYPPE---IVRRDDLVERPDPVVLAFDIETTKLPLKFPDAETDQIMMISYMIDGQGFLITNREIVSEDIEDFEFTPKPEYEGPFTIFNEPDEASLIQRWFEHVHETKPNIFVTYNGDFFDWPFVEARAAQLGLSMHREIGFQKDNQGEYKASQAIHMDCLRWVKRDSYLPVGSHNLKAAAKAKLGYDPVELDPEEMCRMATEEPQTLATYSVSDAVATYYLYMKYVHPFIFALCTIIPMEPDEVLRKGSGTLCEALLMVQAYHVNIVFPNKQEQVFNKLTDDGHVLDSETYVGGHVEALESGVFRSDIPCRFKMNPAAFDFLIQRVERTLRHAIEEEEKIPLEQVTNFNEVCDEIKRKLISLKEVPNRIECPLIYHLDVGAMYPNIILTNRLQPSAMVDEATCAACDFNKPGANCQRRMTWQWRGEIMPASRSEFHRIQQQLESEKFPPVFPNGPPRAFHELNREEQARHEKKRLGDYCRKAYKKVHLTRLEERVTTICQRENSFYVDTVRAFRDRRYEFKGLHKVWKKKLS--TAQDNGDAAEVKRCKNMEILYESLQLAHKCILNSFYGYVMRKGARWYSMEMAGIVCYTGANIITQARELIEQIGRPLELDTDGIWCVLPNTFPENFVIKSTNEKKPKVTISYPGAMLNIMVKEGFTNHQYQELVDAASLTYETRAENSIFFEVDGPYLAMILPASKEEGKKLKKRYAVFNEDGSLAELKGFEVKRRGELQLIKIFQSSVFEAFLKGTTLEEVYASVAKVADYWLDVLYSKAANMPDAELFELISENRSMSRKLEDYGEQKSTSISTAKRLAEFLGDQMVKDAGLSCRYVISRKPEGSPVTERAIPLAIFQAEESVKKHFLRKWLKMPSLHDLDIRSILDWSYYIERLGSAIQKIITIPAALQQVKNPVPRVRHPDWLHKKLLEKNDIYKQKKISELFTSEGKRQVAQQTLAAGETPDMEDLAAPQRPVQPAILISTKRKRISQGEDSQ-TETQEQELTQSWREILGPPPAMGATREEILVWLRYHKKKWELQLRQRKERRKRRRLIDGESQPTGGGVIRGGPTTGLGSFLRRTARSILDMPWQIVQIAETSHPGLYKLWAVIGSDLHCMKLNIPRVFYVNQRVPKQE-EAATCKKVNRILPRSGVACFLYQYTVPEDMYQEHINEINADLSAPDIEGVYETQVPLLFRALVQLGCMCMVNK-HVVRDLAGREADTFDLEHLEMRSLAQFSYLEPGSVRHIYLYHHSQGHKALFGLFIPSQRKASIFVLDTVRSN----QMPNLNSLYGAERTALLE-KTTEELLP--PEKHLFEVRAENDIKAIYRALQRILLNYKEERRGPTLIAVQSNWELRRLAAGMTVLEEFPVVPVHVID-EISYNVLDWQRHGARRMIKHYLNLDSCLSQAFDMARYYHLPVGNLPQDISIF-----GSDLFLARHLRKHNHLLWLSPTARPDLGGKEADDSRLVMESDE--RGSMEINSQGCYSTVCVELDIQSLAVNTILQSQHVNDMEGG-----ASIGVSFDVIQHASLEEMMSG---NQGANAVASYDETALCSNTFRILKSMVVGWVREITQYHNVYADNQVMHFYRWLRSPSSLLYDPALHRTLLNMMKKIFLQLVAEFKRLGSSVIYGNFNRLILCTKKRRIDDAIAYVEYITNSIHTKEIFHSLSITFSRCWEFLLWMDPANCGGVKGKLPSSLLYGEHDSEK-KKKDGAEEDGSDDEDEHEENQEEDEEQDREEDVEDLIESNWNIMQYLPQTASCQKYFLMIISAYIAAVYHSMRQELRRNAPGATPIKRRGATQASQQPSGDVSALPGLITFSQEYVSSELTQNFFTITQKIQKKVSSTRSVTLPSEMF-------------PVLPGSHLPLNNPALEFIKYVCQVLSLDANIVNQVNKLKRDLLRLVDVGEFSEDAQFRDPCKS-------------YVLPEVICHHCNFCRDLDLCKDPAVSQDGSVLPQWF-CSNCQAQYDTESIEMALVEALQKKLMSYTLQDVECAKC-KGVKEANMPLY---CSCAGDFNLTFTTKSFSEQVEVFRNIAAHYNMSFLLETIDWII 2280
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BLAST of DNA polymerase epsilon catalytic subunit vs. Ensembl Zebrafish
Match: pole (polymerase (DNA directed), epsilon [Source:ZFIN;Acc:ZDB-GENE-070705-557])

HSP 1 Score: 2053.87 bits (5320), Expect = 0.000e+0
Identity = 1056/2313 (45.65%), Postives = 1494/2313 (64.59%), Query Frame = 3 
Query:  102 EKILRLKKNDQIDLVYGFDLHSAIKIRTGWLINMKTTDAIDDNKRLVSAMSYYFLEEDGSKFKSTLIFQPYFYIVTKLGCESEIQTYLMKKYSACLHNIEIIEKEDLDLDNHXXXXXXXXXXXXXHTIDDLVRVRKEIMPKIKQNQKNQESDNDYSKMLTEHFQGEK---KYEYNARKSALDIMDNAIDIREYDVPYHVRVSIDTAIFIGKWYDVHGSMNIKGPNSTHITPRSDIVDHPEPIVLAYDIETTKLPLKFPDATFDQIMMISYMIDGMGYLICNREIIADDIEDFEFTPRPEFPGPFSVFNEPNEKRTIERFFDHIREVKPNIFVTYNGDFFDWPFVETRAVKHGLDMLDYIGFSKDNQNEYKSRSAIHMDCFKWVQRDSYLPIGAQGLKAVCKAKLRYNPVEVDPEEMCKVAREDPRTLANYSVSDAVATYYLYMKYVHPFIFALCTIIPMDPDEVLRKGSGTLCECLLMVEAFNSNIIFPNKQESKLNPLTNDGHVIESETYVGGHVEAIESGVFRSDIPTKFKIVPEMCKFLRKNLKETLVHVLEVEEKVTVDSVLNFDEVYNAIDEKLEDLEETNIRFECPVIYHLDVAAMYPNIILSNRLQPSALVNEKTCGACDFNVPNAKCKRPMTWKWRGEIMPATKSEYYLIQNQLEKEKFPPKKPSLPMRSFYELDKLEQATVEKERLGKFCRNAYNRKHNTRFEERTAVVCQRENAFYVDTVRAFRDRRYQYKDLTKVSKKRLDELISSENGDASEIKRANGMLVLYDSLQLAHKCILNSFYGYVMRKGARWYSMEMAGIVCSTGAAIIKYAREMIEQIGRPLELDTDGIWCILPASFPQGFEFQTNNPKKRNISFSYPGAMLNLMVQQYFTNDQYHDLVDPAKHTYRIRSENSIFFEVDGPYLAMILPASKEMNKKLKKRYAVFNRDRSLAELKGFEVKRNGELNLIKIFQSSVFESFLKGSSISEVYQHVAIVANYWLDLLYSRASTMPDEELFELISEKRCMSKKLEEYGKQKSTSISTARRLAEFLGDEMVKDAGLSFKFIISKKPEGQQVTDRAIPVAIFQAEESVKRFYLSKWLKSKDLQDFDIRNILDWDYYINRFSSNIQKIITIPAALQEVPNPVPRVAHPDWLHKILMEKDNRFKQQRITDIFQT-----ITPSQAAADKMKDIEN-CAPISKKKPTGVTSLKRARNKDTVDVYGVQLDMDNLPNHWRDILGDPVPKGNSKSQFIVWLEFHXXXXXXXXXXXDQSELSKENINPATVKRIKTV-KKGIQSGISSFFTRSKQSILEDTWQIIQITDTNVSGIYRVWVLIGQEIHNMKLTVPRTFYVNTRIPKAPGENMYFKQVHKLLPRSRIVYHLYEYNLDETIFIKHRSDILSEFIRNEVEGIYELEVPLLLRVYAKLGCMCSIDRNHFTDQQLSNNPSSFLLNELKFRSTAQHPYLSPNSIKTTFLFQQKSNRNEIIGWFDPCNNRAHLCLVEQSKPNPDKFQANVVQSWFSREREAFLSLKENESLISVVPEHVQFEVSSHKFEISAFKAINKLLVAHRNEVTTPTFIATKSKMTINELYSNLPALQEYPLVPITINETDVSFNVLDWQRIAIKSALQNFVKYEKLLAEMLERARYLHIPVGNMSKFTNDYRGISDSYDLFYGRFLMKNNFIWWCNDKSEPDLGKKENQDRRMMLVDNDVLNGMIYRNKPGCYPTTCVQLEMTYFPINTIIAMHKVMEIDGTNERLFESMIVPAKTIDQAMIQSKCNAAKRNLNLTSNTMYDDVTAAGPAFKILRNVILQWLDDVRNYKNPVADEHLMGFYKWMKNSRSLFYDPALFKSLQKLMRMVFFKLIEQLNNLGVEVIYGTLNKIVLCTKRTDLMDALVHVEYATKTVRNQDIFSQLDFQYVSGWDYLIWQDVSNYSGIKSDL-ESVTKEEHNSMVLEELSFVNMTNPSLSMGLSQSQNEDSFLTTEIADSSQIEMNWHLSRYLSPMSGVQLRLIEILQYFMLTNWKIVKDEYKLNRLAAKNDVAEEAVNTGTILGSDASLYPSSVQRMEDFLQNEMGYKLYLLVSQLKDVPRMHNAVPLTTXXXXXXXXXXXSNKTPPLLPLKNKVSLHPIVDLIKTTCHILALDTSARYYVNDWKRNMFKLINFDAYSDQAKWRSPYSSDQSMGDAFRSDLIITVPEVICDNCNVTRDLDLCRD--LYQVRIKNSWWFVCPTCDFPYDRNVIQETLIDQVRCICESNVMQDLKCTKCTNGILETSLAGTENCVKCGNAIQVTQNAASLKEKIKIYADIGKHYDLPYLHMMTSWML 7001
            +++ R +  D +D  +GF+       +TGWLINM  T+ +DD+KR++SA+ YYF++EDG++FK  L ++PYFYI TK   E E+ ++L KK+   +  +E + KEDLDL NHL+GLK+ ++KL F+T+DDL++V++EI P +++N++ ++S++ Y+ ML+    G     + E  + K   + +DN +D+REYDVPYHVRVSID  I +  WY+V    +   P    I  R D+V+ P+P+VLA+DIETTKLPLKFPDA  DQIMMISYMIDG G+LI NREI+++DIEDFEFTP+PE+ GPF++FNEP+E R   ++ +       N  +++  D    PFVE RA + GL M   IGF KDNQ EYK+  AIHMDC +WV+RDSYLP+G+  LKA  KAKL Y+PVE+DPEEMC++A E+P+TLA YSVSDAVATYYLYMKYVHPFIFALCTIIPM+PDEVLRKGSGTLCE LLMV+A++ NI+FPNKQE   N LT+DGHV++SETYVGGHVEA+ESGVFRSDIP +FK+ P    FL + ++ TL H +E EEK+ ++ V NF+EV + I  KL  L+E   R ECP+IYHLDV AMYPNIIL+NRLQPSA+V+E TC ACDFN P A C+R MTW+WRGEIMPA++SE++ IQ QLE EKFPP  P+ P R+F+EL++ EQA  EK+RLG +CR AY + H TR EER   +CQREN+FYVDTVRAFRDRRY++K L KV KK+L    + +NGDA+E+KR   M +LY+SLQLAHKCILNSFYGYVMRKGARWYSMEMAGIVC TGA II  ARE+IEQIGRPLELDTDGIWC+LP +FP+ F  ++ N KK  ++ SYPGAMLN+MV++ FTN QY +LVD A  TY  R+ENSIFFEVDGPYLAMILPASKE  KKLKKRYAVFN D SLAELKGFEVKR GEL LIKIFQSSVFE+FLKG+++ EVY  VA VA+YWLD+LYS+A+ MPD ELFELISE R MS+KLE+YG+QKSTSISTA+RLAEFLGD+MVKDAGLS +++IS+KPEG  VT+RAIP+AIFQAEESVK+ +L KWLK   L D DIR+ILDW YYI R  S IQKIITIPAALQ+V NPVPRV HPDWLHK L+EK++ +KQ++I+++F +     +     AA +  D+E+  AP    +P  + S KR R     D    +     L   WR+ILG P   G ++ + +VWL +HKKKW++Q   + +    +  I+  +      V + G  +G+ SF  R+ +SIL+  WQI+QI +T+  G+Y++W +IG ++H MKL +PR FYVN R+PK   E    K+V+++LPRS +   LY+Y + E ++ +H ++I ++    ++EG+YE +VPLL R   +LGCMC +++ H           +F L  L+ RS AQ  YL P S++  +L+        + G F P   +A + +++  + N    Q   + S +  ER A L  K  E L+   PE   FEV +     + ++A+ ++L+ ++ E   PT IA +S   +  L + +  L+E+P+VP+ + + ++S+NVLDWQR   +  +++++  +  L++  + ARY H+PVGN+ +  + +       DLF  R L K+N + W +  + PDLG KE  D R+++  ++   G +  N  GCY T CV+L++    +NTI+    V +++G       S+ V    I  A ++   +    N    +   YD+       F+IL+++++ W+ ++  Y N  AD  +M FY+W+++  SL YDPAL ++L  +M+ +F +L+ +   LG  VIYG  N+++LCTK+  + DA+ +VEY T ++  ++IF  L   +   W++L+W D +N  G+K  L  S+   EH+S   ++                ++Q ED     E      IE NW++ +YL   +  Q   + I+  ++   +  ++ E + N   A       A         D S  P  +   ++++ +E+    + +  +++       +V L ++               P+LP  +    +P ++ IK  C +L+LD +    VN  KR++ +L++   +S+ A++R P  S               +PEVIC +CN  RDLDLC+D  + Q       WF C  C   YD   I+  L++ ++    S  +QD++C KC  G+ E ++        C     +T    S  E+++++ +I  HY++ +L     W++
Sbjct:   31 KRLERSQFTDSMDERFGFERMKEPGEKTGWLINMHPTEILDDDKRMISAVDYYFIQEDGNRFKVALPYKPYFYIATKKNTEREVISFLSKKFQGKVAKLESVPKEDLDLPNHLVGLKRNYIKLSFNTVDDLIKVKREISPAVRKNREREKSNDAYTSMLSSALVGGSVVTEDEGGSSKKMTEQLDNILDMREYDVPYHVRVSIDLKIHVAHWYNVRYRGSAYPPE---IVRRDDLVERPDPVVLAFDIETTKLPLKFPDAETDQIMMISYMIDGQGFLITNREIVSEDIEDFEFTPKPEYEGPFTIFNEPDEVRLNSKYVN-------NWPLSFR-DGLSTPFVEARAAQLGLSMHREIGFQKDNQGEYKASQAIHMDCLRWVKRDSYLPVGSHNLKAAAKAKLGYDPVELDPEEMCRMATEEPQTLATYSVSDAVATYYLYMKYVHPFIFALCTIIPMEPDEVLRKGSGTLCEALLMVQAYHVNIVFPNKQEQVFNKLTDDGHVLDSETYVGGHVEALESGVFRSDIPCRFKMNPAAFDFLIQRVERTLRHAIEEEEKIPLEQVTNFNEVCDEIKRKLISLKEVPNRIECPLIYHLDVGAMYPNIILTNRLQPSAMVDEATCAACDFNKPGANCQRRMTWQWRGEIMPASRSEFHRIQQQLESEKFPPVFPNGPPRAFHELNREEQARHEKKRLGDYCRKAYKKVHLTRLEERVTTICQRENSFYVDTVRAFRDRRYEFKGLHKVWKKKLS--TAQDNGDAAEVKRCKNMEILYESLQLAHKCILNSFYGYVMRKGARWYSMEMAGIVCYTGANIITQARELIEQIGRPLELDTDGIWCVLPNTFPENFVIKSTNEKKPKVTISYPGAMLNIMVKEGFTNHQYQELVDAASLTYETRAENSIFFEVDGPYLAMILPASKEEGKKLKKRYAVFNEDGSLAELKGFEVKRRGELQLIKIFQSSVFEAFLKGTTLEEVYASVAKVADYWLDVLYSKAANMPDAELFELISENRSMSRKLEDYGEQKSTSISTAKRLAEFLGDQMVKDAGLSCRYVISRKPEGSPVTERAIPLAIFQAEESVKKHFLRKWLKMPSLHDLDIRSILDWSYYIERLGSAIQKIITIPAALQQVKNPVPRVRHPDWLHKKLLEKNDIYKQKKISELFTSEGKRQVAQQTLAAGETPDMEDLAAPQRPVQPAILISTKRKRISQGEDSQ-TETQEQELTQSWREILGPPPAMGATREEILVWLRYHKKKWELQLRQRKERRKRRRLIDGESQPTGGGVIRGGPTTGLGSFLRRTARSILDMPWQIVQIAETSHPGLYKLWAVIGSDLHCMKLNIPRVFYVNQRVPKQE-EAATCKKVNRILPRSGVACFLYQYTVPEDMYQEHINEINADLSAPDIEGVYETQVPLLFRALVQLGCMCMVNK-HVVRDLAGREADTFDLEHLEMRSLAQFSYLEPGSVRHIYLYHHSQGHKALFGLFIPSQRKASIFVLDTVRSN----QMPNLNSLYGAERTALLE-KTTEELLP--PEKHLFEVRAENDIKAIYRALQRILLNYKEERRGPTLIAVQSNWELRRLAAGMTVLEEFPVVPVHVID-EISYNVLDWQRHGARRMIKHYLNLDSCLSQAFDMARYYHLPVGNLPQDISIF-----GSDLFLARHLRKHNHLLWLSPTARPDLGGKEADDSRLVMESDE--RGSMEINSQGCYSTVCVELDIQSLAVNTILQSQHVNDMEGG-----ASIGVSFDVIQHASLEEMMSG---NQGANAVASYDETALCSNTFRILKSMVVGWVREITQYHNVYADNQVMHFYRWLRSPSSLLYDPALHRTLLNMMKKIFLQLVAEFKRLGSSVIYGNFNRLILCTKKRRIDDAIAYVEYITNSIHTKEIFHSLSITFSRCWEFLLWMDPANCGGVKGKLPSSLLYGEHDSEK-KKKDGAEEDGSDDEDEHEENQEEDEEQDREEDVEDLIESNWNIMQYLPQTASCQKYFLMIISAYIAAVYHSMRQELRRNAPGATPIKRRGATQASQQPSGDVSALPGLITFSQEYVSSELTQNFFTITQKIQKKVSSTRSVTLPSEMF-------------PVLPGSHLPLNNPALEFIKYVCQVLSLDANIVNQVNKLKRDLLRLVDVGEFSEDAQFRDPCKS-------------YVLPEVICHHCNFCRDLDLCKDPAVSQDGSVLPQWF-CSNCQAQYDTESIEMALVEALQKKLMSYTLQDVECAKC-KGVKEANMPLY---CSCAGDFNLTFTTKSFSEQVEVFRNIAAHYNMSFLLETIDWII 2272
[Close]
BLAST of DNA polymerase epsilon catalytic subunit vs. Ensembl Xenopus
Match: prmt8 (protein arginine methyltransferase 8 [Source:Xenbase;Acc:XB-GENE-6037618])

HSP 1 Score: 2150.17 bits (5570), Expect = 0.000e+0
Identity = 1084/2320 (46.72%), Postives = 1521/2320 (65.56%), Query Frame = 3 
Query:  102 EKILRLKKNDQIDLVYGFDLHSAIKIRTGWLINMKTTDAIDDNKRLVSAMSYYFLEEDGSKFKSTLIFQPYFYIVTKLGCESEIQTYLMKKYSACLHNIEIIEKEDLDLDNHXXXXXXXXXXXXXHTIDDLVRVRKEIMPKIKQNQKNQESDNDYSKMLTEHFQGEK--KYEYNARKSALDIMDNAIDIREYDVPYHVRVSIDTAIFIGKWYDVHGSMNIKGPNSTHITPRSDIVDHPEPIVLAYDIETTKLPLKFPDATFDQIMMISYMIDGMGYLICNREIIADDIEDFEFTPRPEFPGPFSVFNEPNEKRTIERFFDHIREVKPNIFVTYNGDFFDWPFVETRAVKHGLDMLDYIGFSKDNQNEYKSRSAIHMDCFKWVQRDSYLPIGAQGLKAVCKAKLRYNPVEVDPEEMCKVAREDPRTLANYSVSDAVATYYLYMKYVHPFIFALCTIIPMDPDEVLRKGSGTLCECLLMVEAFNSNIIFPNKQESKLNPLTNDGHVIESETYVGGHVEAIESGVFRSDIPTKFKIVPEMCKFLRKNLKETLVHVLEVEEKVTVDSVLNFDEVYNAIDEKLEDLEETNIRFECPVIYHLDVAAMYPNIILSNRLQPSALVNEKTCGACDFNVPNAKCKRPMTWKWRGEIMPATKSEYYLIQNQLEKEKFPPKKPSLPMRSFYELDKLEQATVEKERLGKFCRNAYNRKHNTRFEERTAVVCQRENAFYVDTVRAFRDRRYQYKDLTKVSKKRLDELISSENGDASEIKRANGMLVLYDSLQLAHKCILNSFYGYVMRKGARWYSMEMAGIVCSTGAAIIKYAREMIEQIGRPLELDTDGIWCILPASFPQGFEFQTNNPKKRNISFSYPGAMLNLMVQQYFTNDQYHDLVDPAKHTYRIRSENSIFFEVDGPYLAMILPASKEMNKKLKKRYAVFNRDRSLAELKGFEVKRNGELNLIKIFQSSVFESFLKGSSISEVYQHVAIVANYWLDLLYSRASTMPDEELFELISEKRCMSKKLEEYGKQKSTSISTARRLAEFLGDEMVKDAGLSFKFIISKKPEGQQVTDRAIPVAIFQAEESVKRFYLSKWLKSKDLQDFDIRNILDWDYYINRFSSNIQKIITIPAALQEVPNPVPRVAHPDWLHKILMEKDNRFKQQRITDIFQ-------TITPSQAAADKMKDIENCAPISKKKPTGVTSLKRARNKDTVDVYGVQLDMDNLPNHWRDILGDPVPKGNSKSQFIVWLEFHXXXXXXXXXXXDQSE----LSKENINPATVKRIKTVKKGIQSGISSFFTRSKQSILEDTWQIIQITDTNVSGIYRVWVLIGQEIHNMKLTVPRTFYVNTRIPKAPGENMYFKQVHKLLPRSRIVYHLYEYNLDETIFIKHRSDILSEFIRNEVEGIYELEVPLLLRVYAKLGCMCSIDRN---HFTDQQLSNNPSSFLLNELKFRSTAQHPYLSPNSIKTTFLFQQKSNRNEIIGWFDPCNNRAHLCLVEQSKPNPDKFQANVVQSWFSREREAFLSLKENESLISVVPEHVQFEVSSHKFEISAFKAINKLLVAHRNEVTTPTFIATKSKMTINELYSNLPALQEYPLVPITINETDVSFNVLDWQRIAIKSALQNFVKYEKLLAEMLERARYLHIPVGNMSKFTNDYRGISDSYDLFYGRFLMKNNFIWWCNDKSEPDLGKKENQDRRMMLVDNDVLNGMIYRNKPGCYPTTCVQLEMTYFPINTIIAMHKVMEIDGTNERLFESMIVPAKTIDQAMIQSKCNAAKRNLNLTSNTMYDDVTAAGPAFKILRNVILQWLDDVRNYKNPVADEHLMGFYKWMKNSRSLFYDPALFKSLQKLMRMVFFKLIEQLNNLGVEVIYGTLNKIVLCTKRTDLMDALVHVEYATKTVRNQDIFSQLDFQYVSGWDYLIWQDVSNYSGIKSDLESVTKEEHNSMVLEELSFVNMTNPSLSMGLSQSQNEDSFLTTEIADSSQIEMNWHLSRYLSPMSGVQLRLIEILQYFMLTNWKIVKDEYKLNRLAAKNDVAEEAVNTGTILGSDASLYPSSVQRMEDFLQNEMGYKLYLLVSQL-KDVPRMHNAVPLTTXXXXXXXXXXXSNKTPPLLPLKNKVSLHPIVDLIKTTCHILALDTSARYYVNDWKRNMFKLINFDAYSDQAKWRSPYSSDQSMGDAFRSDLIITVPEVICDNCNVTRDLDLCRD--LYQVRIKNSWWFVCPTCDFPYDRNVIQETLIDQVRCICESNVMQDLKCTKCTNGILETSLAGTENCVKCGNAIQVTQNAASLKEKIKIYADIGKHYDLPYLHMMTSWMLQ 7004
            +++ R +  D+ID  YGF+       +TGWL+NM   + +D++KRLVSA+ YYF++EDGS+FK  L ++PYFY+ TK GCE E+ ++L KK+   L  +E I KEDLDL NHL+GLK+ ++KL FH++DDL++VRKEI P +++N++   + + Y+ ML+    G      E    K   D M+N +D+REYDVPYHVRVSID  I +  WY++    +   P    IT R D+V+ P+P+VLA+DIETTKLPLKFPDA  DQIMMISYMIDG GYLI NREI+++DIEDFEFTP+PE+ GPF +FNEP+E   I+R+F+H++E KPNI VTYNGDFFDWPFVETRA  HG+ ML  IGF KDNQ EYKS   IHMDC +WV+RDSYLP+G+  LKA  KAKL Y+PVE+DPEEMC++A E+P+ LA YSVSDAVATYY+YMKYVHPFIFALCTIIPM+PDEVLRKGSGTLCE LLMV+A+++NIIFPNKQE+  N LT+DGHV++SETYVGGHVEA+ESGVFRSDIP +FK+ P    FL + ++ TL H +E EEK+ ++ V NF EV   I +KL  L+E   R ECP+IYHLDV AMYPNIIL+NRLQPSA+V+E TC ACDFN P A C+R MTW+WRGE MPA++SEY+ IQ QLE EKFPP  P  P R+F+EL + EQA  EK+RL  +CR AY + H TR EE+   +CQREN+FYVDTVRAFRDRRY++K L KV KK+L    + E+GDA+EIKR   M +LY+SLQLAHKCILNSFYGYVMRKGARWYSMEMAGIVC TGA II  ARE++EQIGRPLELDTDGIWC+LP SFP+ F  ++ N KK  ++ SYPGAMLN++V++ FTN QY +L DPA  TY  RSENSIFFEVDGPYLAMILPASKE  KKLKKRYAVFN D SLAELKGFEVKR GEL LIKIFQSSVFE+FLKGS++ EVY  VA VA+YWLD+LYS+A+ MPD ELFELISE R MS++LE+YG+QKSTSISTA+RLAEFLGD+MVKDAGLS +++IS+KPEG  VT+RAIP+AIFQAE  VKR YL KWLK+  LQD DIR+ILDWDYYI R  S IQKIITIPAALQ+V NPVPRV HPDWLHK L+EK++ +KQ+RI ++F        T    Q  + +  D+E+     + +P    S KR R     D  G   ++  L   WR++LG P P G +K + +VWL +HKKKW++Q   + + +    L   ++ P     I+  +    +G+ SF  R+ +SIL+  WQI+QI +++  G++R+W +IG ++H +KL +PR F+VN RIPK P E   +++V+++LPRS  VYHLYEY + E ++ +H ++I ++    ++EG+YE +VPL++R  ++LGC+C +++    H + ++      +F L  L+ +S AQ+ YL P SI+  +L+        + G F P   ++ + +V+  + N    Q   + + ++ E  A     + E L    PE   FEV +     + ++ I +LL+++++E   PT IA +S   +  L + +P L+E+PLVP+ I + D+S+ VLDWQR   +  +++++  +  L++  E ARY H+PVGN+    + +       DLF+ R L ++N + W +  + PDLG KE  D R+++  ++  +  I  N PGCY T CV+L++    +N+I+  H + +++G       SM +    + QA ++      +     +S   YD+       F+IL+++++ W+ ++  Y N  AD  +M FY+W+++  SL YDPAL ++L  +M+ +F +L+ +   LG  V+Y   N+I+LCTK+  + DA+ +VEY T+++ +++IF  L       W++L+W D +NY G+K  L S      ++   + L               Q  N D   + +  + S +E NW++ +YL   +  Q   + I+  +++  +  +++E + N          +         +D    P  +   +D++ NE+    + +  ++ K V    +A               E ++  P+LP  +    +P ++ IK  C +LALD++    VN  KR++ +L++   +S+ A++R P  S               +PE+IC +CN  RDLDLC+D  + Q       W VC  C   YD + I+  L++ ++    +  +QDL C KC  G+ E ++    N   C     +T +   L E+I ++ +I +HY++ +L     W++Q
Sbjct:   31 KRLERSQWTDKIDAQYGFERIREPGEKTGWLLNMHPNEILDEDKRLVSAVDYYFIQEDGSRFKVALPYKPYFYVATKKGCEREVSSFLSKKFQGKLAKLETIPKEDLDLPNHLVGLKRGYIKLSFHSVDDLIKVRKEISPAVRKNKERDHASDTYTAMLSSALTGNNMGAEEEGPSKKISDQMENIVDMREYDVPYHVRVSIDLKIHVAHWYNIRYRGSSSPPE---ITRRDDLVERPDPVVLAFDIETTKLPLKFPDAETDQIMMISYMIDGQGYLITNREIVSEDIEDFEFTPKPEYEGPFCIFNEPDEAHLIQRWFEHMQETKPNIIVTYNGDFFDWPFVETRASVHGMSMLQEIGFQKDNQGEYKSPPCIHMDCLRWVKRDSYLPVGSHNLKAAAKAKLGYDPVELDPEEMCRMATEEPQVLATYSVSDAVATYYMYMKYVHPFIFALCTIIPMEPDEVLRKGSGTLCEALLMVQAYHANIIFPNKQEAVFNKLTSDGHVLDSETYVGGHVEALESGVFRSDIPCRFKMNPAAFDFLLQRVELTLRHAIEEEEKIPLEQVTNFQEVCEEIKKKLNSLKEVPNRIECPLIYHLDVGAMYPNIILTNRLQPSAMVDEVTCAACDFNKPGATCQRQMTWQWRGEFMPASRSEYHRIQQQLESEKFPPLFPGKPPRAFHELTREEQAKYEKKRLADYCRKAYKKIHVTRLEEKVTTICQRENSFYVDTVRAFRDRRYEFKGLHKVWKKKLSS--ACESGDAAEIKRCKNMEILYESLQLAHKCILNSFYGYVMRKGARWYSMEMAGIVCYTGANIITQARELVEQIGRPLELDTDGIWCVLPNSFPENFVIKSTNAKKPKVTISYPGAMLNILVKEGFTNHQYQELSDPATLTYITRSENSIFFEVDGPYLAMILPASKEEGKKLKKRYAVFNEDGSLAELKGFEVKRRGELQLIKIFQSSVFEAFLKGSTLEEVYASVAKVADYWLDVLYSKAANMPDAELFELISENRSMSRRLEDYGEQKSTSISTAKRLAEFLGDQMVKDAGLSCRYVISRKPEGSPVTERAIPLAIFQAEVGVKRHYLRKWLKNPSLQDLDIRSILDWDYYIERLGSAIQKIITIPAALQQVKNPVPRVRHPDWLHKKLLEKNDIYKQKRINELFTSEGKRQITAQMQQPDSSQTPDMEDFGIGKRLQPAVPISTKRKRVPTAEDSQGDSQNL-ALTQSWREVLGQPPPLGTTKEERLVWLRYHKKKWELQARQRKERQKKRRLEDGDVAPGAGGVIRETQA---AGLGSFLRRTARSILDMPWQIVQIGESSQPGLFRLWAVIGNDLHCIKLNIPRVFFVNQRIPK-PEEGAVYRKVNRILPRSNPVYHLYEYTVPEDMYQEHINEINADLSAPDIEGVYETQVPLIMRAVSQLGCVCMVNKQLVRHLSGRE----ADTFDLEHLEMKSLAQYSYLEPGSIRHIYLYHNSQGHKALFGLFIPSQRKSAVFVVDTVRSN----QMPNLSNMYTAEHTAMQERVDPELL---PPEKHIFEVRAETDLKTVYRGIQRLLLSYKDERRGPTLIAVQSNWNLRRLAAGMPVLEEFPLVPVRITD-DISYGVLDWQRHGARRMIRHYLNLDSCLSQAFEMARYYHLPVGNLPDDVSTF-----GSDLFFSRHLRRHNHLLWLSPSARPDLGGKEADDNRLVMEFDEKASVEI--NNPGCYNTVCVELDIQSLAVNSILQSHHINDLEGAG-----SMGISFDVLQQASLEDMVTGNQ----ASSVASYDETALCSNTFRILKSMVVGWVKEITQYHNVYADNQVMHFYRWLRSPSSLLYDPALHRTLHNMMKKLFLQLVAEFKRLGSSVVYANFNRIILCTKKRRVEDAVAYVEYITQSIHSREIFHSLTISVSRCWEFLLWMDPANYGGVKGKLPSSVHYGESAKKKKALDGEGDDGSEDEEEDDQPVNSDDEQSEDQVEES-LENNWNIVQYLPQAASCQSYFLMIVSAYIVAVYHSMREEMRRNAPGNTPIKRRQNSQVSQEANADGGAMPGLITFSQDYVANELTQNFFTITQKIQKKVTGTRHAT--------------EPSEMFPILPGSHLPLNNPALEFIKYVCEVLALDSNITNQVNKLKRDLLRLVDVGEFSEDAQFRDPCRS-------------YILPEIICRSCNFCRDLDLCKDPAINQDGSVLPQW-VCTNCQAEYDSDGIEMALVEALQKKMMAFTLQDLVCMKC-KGVKEANMPVYCN---CAGDFTLTISVKVLLEQINVFRNIAQHYNMAHLLETIVWIMQ 2279
[Close]
BLAST of DNA polymerase epsilon catalytic subunit vs. Ensembl Xenopus
Match: prmt8 (protein arginine methyltransferase 8 [Source:Xenbase;Acc:XB-GENE-6037618])

HSP 1 Score: 2143.62 bits (5553), Expect = 0.000e+0
Identity = 1084/2320 (46.72%), Postives = 1520/2320 (65.52%), Query Frame = 3 
Query:  102 EKILRLKKNDQIDLVYGFDLHSAIKIRTGWLINMKTTDAIDDNKRLVSAMSYYFLEEDGSKFKSTLIFQPYFYIVTKLGCESEIQTYLMKKYSACLHNIEIIEKEDLDLDNHXXXXXXXXXXXXXHTIDDLVRVRKEIMPKIKQNQKNQESDNDYSKMLTEHFQGEK--KYEYNARKSALDIMDNAIDIREYDVPYHVRVSIDTAIFIGKWYDVHGSMNIKGPNSTHITPRSDIVDHPEPIVLAYDIETTKLPLKFPDATFDQIMMISYMIDGMGYLICNREIIADDIEDFEFTPRPEFPGPFSVFNEPNEKRTIERFFDHIREVKPNIFVTYNGDFFDWPFVETRAVKHGLDMLDYIGFSKDNQNEYKSRSAIHMDCFKWVQRDSYLPIGAQGLKAVCKAKLRYNPVEVDPEEMCKVAREDPRTLANYSVSDAVATYYLYMKYVHPFIFALCTIIPMDPDEVLRKGSGTLCECLLMVEAFNSNIIFPNKQESKLNPLTNDGHVIESETYVGGHVEAIESGVFRSDIPTKFKIVPEMCKFLRKNLKETLVHVLEVEEKVTVDSVLNFDEVYNAIDEKLEDLEETNIRFECPVIYHLDVAAMYPNIILSNRLQPSALVNEKTCGACDFNVPNAKCKRPMTWKWRGEIMPATKSEYYLIQNQLEKEKFPPKKPSLPMRSFYELDKLEQATVEKERLGKFCRNAYNRKHNTRFEERTAVVCQRENAFYVDTVRAFRDRRYQYKDLTKVSKKRLDELISSENGDASEIKRANGMLVLYDSLQLAHKCILNSFYGYVMRKGARWYSMEMAGIVCSTGAAIIKYAREMIEQIGRPLELDTDGIWCILPASFPQGFEFQTNNPKKRNISFSYPGAMLNLMVQQYFTNDQYHDLVDPAKHTYRIRSENSIFFEVDGPYLAMILPASKEMNKKLKKRYAVFNRDRSLAELKGFEVKRNGELNLIKIFQSSVFESFLKGSSISEVYQHVAIVANYWLDLLYSRASTMPDEELFELISEKRCMSKKLEEYGKQKSTSISTARRLAEFLGDEMVKDAGLSFKFIISKKPEGQQVTDRAIPVAIFQAEESVKRFYLSKWLKSKDLQDFDIRNILDWDYYINRFSSNIQKIITIPAALQEVPNPVPRVAHPDWLHKILMEKDNRFKQQRITDIFQ-------TITPSQAAADKMKDIENCAPISKKKPTGVTSLKRARNKDTVDVYGVQLDMDNLPNHWRDILGDPVPKGNSKSQFIVWLEFHXXXXXXXXXXXDQSE----LSKENINPATVKRIKTVKKGIQSGISSFFTRSKQSILEDTWQIIQITDTNVSGIYRVWVLIGQEIHNMKLTVPRTFYVNTRIPKAPGENMYFKQVHKLLPRSRIVYHLYEYNLDETIFIKHRSDILSEFIRNEVEGIYELEVPLLLRVYAKLGCMCSIDRN---HFTDQQLSNNPSSFLLNELKFRSTAQHPYLSPNSIKTTFLFQQKSNRNEIIGWFDPCNNRAHLCLVEQSKPNPDKFQANVVQSWFSREREAFLSLKENESLISVVPEHVQFEVSSHKFEISAFKAINKLLVAHRNEVTTPTFIATKSKMTINELYSNLPALQEYPLVPITINETDVSFNVLDWQRIAIKSALQNFVKYEKLLAEMLERARYLHIPVGNMSKFTNDYRGISDSYDLFYGRFLMKNNFIWWCNDKSEPDLGKKENQDRRMMLVDNDVLNGMIYRNKPGCYPTTCVQLEMTYFPINTIIAMHKVMEIDGTNERLFESMIVPAKTIDQAMIQSKCNAAKRNLNLTSNTMYDDVTAAGPAFKILRNVILQWLDDVRNYKNPVADEHLMGFYKWMKNSRSLFYDPALFKSLQKLMRMVFFKLIEQLNNLGVEVIYGTLNKIVLCTKRTDLMDALVHVEYATKTVRNQDIFSQLDFQYVSGWDYLIWQDVSNYSGIKSDLESVTKEEHNSMVLEELSFVNMTNPSLSMGLSQSQNEDSFLTTEIADSSQIEMNWHLSRYLSPMSGVQLRLIEILQYFMLTNWKIVKDEYKLNRLAAKNDVAEEAVNTGTILGSDASLYPSSVQRMEDFLQNEMGYKLYLLVSQL-KDVPRMHNAVPLTTXXXXXXXXXXXSNKTPPLLPLKNKVSLHPIVDLIKTTCHILALDTSARYYVNDWKRNMFKLINFDAYSDQAKWRSPYSSDQSMGDAFRSDLIITVPEVICDNCNVTRDLDLCRD--LYQVRIKNSWWFVCPTCDFPYDRNVIQETLIDQVRCICESNVMQDLKCTKCTNGILETSLAGTENCVKCGNAIQVTQNAASLKEKIKIYADIGKHYDLPYLHMMTSWMLQ 7004
            +++ R +  D+ID  YGF+       +TGWL+NM   + +D++KRLVSA+ YYF++EDGS+FK  L ++PYFY+ TK GCE E+ ++L KK+   L  +E I KEDLDL NHL+GLK+ ++KL FH++DDL++VRKEI P +++N++   + + Y+ ML+    G      E    K   D M+N +D+REYDVPYHVRVSID  I +  WY++    +   P    IT R D+V+ P+P+VLA+DIETTKLPLKFPDA  DQIMMISYMIDG GYLI NREI+++DIEDFEFTP+PE+ GPF +FNEP+E   I+R+F+H++E KPNI VTYNGDFFDWPFVETRA  HG+ ML  IGF KDNQ EYKS   IHMDC +WV+RDSYLP+G+  LKA  KAKL Y+PVE+DPEEMC++A E+P+ LA YSVSDAVATYY+YMKYVHPFIFALCTIIPM+PDEVLRKGSGTLCE LLMV+A+++NIIFPNKQE+  N LT+DGHV++SETYVGGHVEA+ESGVFRSDIP +FK+ P    FL + ++ TL H +E EEK+ ++ V NF EV   I +KL  L+E   R ECP+IYHLDV AMYPNIIL+NRLQPSA+V+E TC ACDFN P A C+R MTW+WRGE MPA++SEY+ IQ QLE EKFPP  P  P R+F+EL + EQA  EK+RL  +CR AY + H TR EE+   +CQREN+FYVDTVRAFRDRRY++K L KV KK+L    + E+GDA+EIKR   M +LY+SLQLAHKCILNSFYGYVMRKGARWYSMEMAGIVC TGA II  ARE++EQIGRPLELDTDGIWC+LP SFP+ F  ++ N KK  ++ SYPGAMLN++V++ FTN QY +L DPA  TY  RSENSIFFEVDGPYLAMILPASKE  KKLKKRYAVFN D SLAELKGFEVKR GEL LIKIFQSSVFE+FLKGS++ EVY  VA VA+YWLD+LYS+A+ MPD ELFELISE R MS++LE+YG+QKSTSISTA+RLAEFLGD+MVKDAGLS +++IS+KPEG  VT+RAIP+AIFQAE  VKR YL KWLK+  LQD DIR+ILDWDYYI R  S IQKIITIPAALQ+V NPVPRV HPDWLHK L+EK++ +KQ+RI ++F        T    Q  + +  D+E+     + +P    S KR R     D  G   ++  L   WR++LG P P G +K + +VWL +HKKKW++Q   + + +    L   ++ P     I+  +    +G+ SF  R+ +SIL+  WQI+QI +++  G++R+W +IG ++H +KL +PR F+VN RIPK P E   +++V+++LPRS  VYHLYEY + E ++ +H ++I ++    ++EG+YE +VPL++R  ++LGC+C +++    H + ++      +F L  L+ +S AQ+ YL P SI+  +L+        + G F P   ++ + +V+  + N    Q   + + ++ E  A     + E L    PE   FEV +     + ++ I +LL+++++E   PT IA +S   +  L + +P L+E+PLVP+ I + D+S+ VLDWQR   +  +++++  +  L++  E ARY H+PVGN+    + +       DLF+ R L ++N + W +  + PDLG KE  D R+++  ++  +  I  N PGCY T CV+L++    +N+I+  H + +++G       SM +    + QA ++      +     +S   YD+       F+IL+++++ W+ ++  Y N  AD  +M FY+W+++  SL YDPAL ++L  +M+ +F +L+ +   LG  V+Y   N+I+LCTK+  + DA+ +VEY T+++ +++IF  L       W++L+W D +NY G+K  L S       S+   E+   +       +     Q+ED            +E NW++ +YL   +  Q   + I+  +++  +  +++E + N          +         +D    P  +   +D++ NE+    + +  ++ K V    +A               E ++  P+LP  +    +P ++ IK  C +LALD++    VN  KR++ +L++   +S+ A++R P  S               +PE+IC +CN  RDLDLC+D  + Q       W VC  C   YD + I+  L++ ++    +  +QDL C KC  G+ E ++    N   C     +T +   L E+I ++ +I +HY++ +L     W++Q
Sbjct:   36 KRLERSQWTDKIDAQYGFERIREPGEKTGWLLNMHPNEILDEDKRLVSAVDYYFIQEDGSRFKVALPYKPYFYVATKKGCEREVSSFLSKKFQGKLAKLETIPKEDLDLPNHLVGLKRGYIKLSFHSVDDLIKVRKEISPAVRKNKERDHASDTYTAMLSSALTGNNMGAEEEGPSKKISDQMENIVDMREYDVPYHVRVSIDLKIHVAHWYNIRYRGSSSPPE---ITRRDDLVERPDPVVLAFDIETTKLPLKFPDAETDQIMMISYMIDGQGYLITNREIVSEDIEDFEFTPKPEYEGPFCIFNEPDEAHLIQRWFEHMQETKPNIIVTYNGDFFDWPFVETRASVHGMSMLQEIGFQKDNQGEYKSPPCIHMDCLRWVKRDSYLPVGSHNLKAAAKAKLGYDPVELDPEEMCRMATEEPQVLATYSVSDAVATYYMYMKYVHPFIFALCTIIPMEPDEVLRKGSGTLCEALLMVQAYHANIIFPNKQEAVFNKLTSDGHVLDSETYVGGHVEALESGVFRSDIPCRFKMNPAAFDFLLQRVELTLRHAIEEEEKIPLEQVTNFQEVCEEIKKKLNSLKEVPNRIECPLIYHLDVGAMYPNIILTNRLQPSAMVDEVTCAACDFNKPGATCQRQMTWQWRGEFMPASRSEYHRIQQQLESEKFPPLFPGKPPRAFHELTREEQAKYEKKRLADYCRKAYKKIHVTRLEEKVTTICQRENSFYVDTVRAFRDRRYEFKGLHKVWKKKLSS--ACESGDAAEIKRCKNMEILYESLQLAHKCILNSFYGYVMRKGARWYSMEMAGIVCYTGANIITQARELVEQIGRPLELDTDGIWCVLPNSFPENFVIKSTNAKKPKVTISYPGAMLNILVKEGFTNHQYQELSDPATLTYITRSENSIFFEVDGPYLAMILPASKEEGKKLKKRYAVFNEDGSLAELKGFEVKRRGELQLIKIFQSSVFEAFLKGSTLEEVYASVAKVADYWLDVLYSKAANMPDAELFELISENRSMSRRLEDYGEQKSTSISTAKRLAEFLGDQMVKDAGLSCRYVISRKPEGSPVTERAIPLAIFQAEVGVKRHYLRKWLKNPSLQDLDIRSILDWDYYIERLGSAIQKIITIPAALQQVKNPVPRVRHPDWLHKKLLEKNDIYKQKRINELFTSEGKRQITAQMQQPDSSQTPDMEDFGIGKRLQPAVPISTKRKRVPTAEDSQGDSQNL-ALTQSWREVLGQPPPLGTTKEERLVWLRYHKKKWELQARQRKERQKKRRLEDGDVAPGAGGVIRETQA---AGLGSFLRRTARSILDMPWQIVQIGESSQPGLFRLWAVIGNDLHCIKLNIPRVFFVNQRIPK-PEEGAVYRKVNRILPRSNPVYHLYEYTVPEDMYQEHINEINADLSAPDIEGVYETQVPLIMRAVSQLGCVCMVNKQLVRHLSGRE----ADTFDLEHLEMKSLAQYSYLEPGSIRHIYLYHNSQGHKALFGLFIPSQRKSAVFVVDTVRSN----QMPNLSNMYTAEHTAMQERVDPELL---PPEKHIFEVRAETDLKTVYRGIQRLLLSYKDERRGPTLIAVQSNWNLRRLAAGMPVLEEFPLVPVRITD-DISYGVLDWQRHGARRMIRHYLNLDSCLSQAFEMARYYHLPVGNLPDDVSTF-----GSDLFFSRHLRRHNHLLWLSPSARPDLGGKEADDNRLVMEFDEKASVEI--NNPGCYNTVCVELDIQSLAVNSILQSHHINDLEGAG-----SMGISFDVLQQASLEDMVTGNQ----ASSVASYDETALCSNTFRILKSMVVGWVKEITQYHNVYADNQVMHFYRWLRSPSSLLYDPALHRTLHNMMKKLFLQLVAEFKRLGSSVVYANFNRIILCTKKRRVEDAVAYVEYITQSIHSREIFHSLTISVSRCWEFLLWMDPANYGGVKGKLPS-------SVHYGEVRPEDEEEDDQPVNSDDEQSEDQV-------EESLENNWNIVQYLPQAASCQSYFLMIVSAYIVAVYHSMREEMRRNAPGNTPIKRRQNSQVSQEANADGGAMPGLITFSQDYVANELTQNFFTITQKIQKKVTGTRHAT--------------EPSEMFPILPGSHLPLNNPALEFIKYVCEVLALDSNITNQVNKLKRDLLRLVDVGEFSEDAQFRDPCRS-------------YILPEIICRSCNFCRDLDLCKDPAINQDGSVLPQW-VCTNCQAEYDSDGIEMALVEALQKKMMAFTLQDLVCMKC-KGVKEANMPVYCN---CAGDFTLTISVKVLLEQINVFRNIAQHYNMAHLLETIVWIMQ 2271
[Close]
BLAST of DNA polymerase epsilon catalytic subunit vs. Ensembl Xenopus
Match: prmt8 (protein arginine methyltransferase 8 [Source:Xenbase;Acc:XB-GENE-6037618])

HSP 1 Score: 2143.62 bits (5553), Expect = 0.000e+0
Identity = 1085/2320 (46.77%), Postives = 1521/2320 (65.56%), Query Frame = 3 
Query:  102 EKILRLKKNDQIDLVYGFDLHSAIKIRTGWLINMKTTDAIDDNKRLVSAMSYYFLEEDGSKFKSTLIFQPYFYIVTKLGCESEIQTYLMKKYSACLHNIEIIEKEDLDLDNHXXXXXXXXXXXXXHTIDDLVRVRKEIMPKIKQNQKNQESDNDYSKMLTEHFQGEK--KYEYNARKSALDIMDNAIDIREYDVPYHVRVSIDTAIFIGKWYDVHGSMNIKGPNSTHITPRSDIVDHPEPIVLAYDIETTKLPLKFPDATFDQIMMISYMIDGMGYLICNREIIADDIEDFEFTPRPEFPGPFSVFNEPNEKRTIERFFDHIREVKPNIFVTYNGDFFDWPFVETRAVKHGLDMLDYIGFSKDNQNEYKSRSAIHMDCFKWVQRDSYLPIGAQGLKAVCKAKLRYNPVEVDPEEMCKVAREDPRTLANYSVSDAVATYYLYMKYVHPFIFALCTIIPMDPDEVLRKGSGTLCECLLMVEAFNSNIIFPNKQESKLNPLTNDGHVIESETYVGGHVEAIESGVFRSDIPTKFKIVPEMCKFLRKNLKETLVHVLEVEEKVTVDSVLNFDEVYNAIDEKLEDLEETNIRFECPVIYHLDVAAMYPNIILSNRLQPSALVNEKTCGACDFNVPNAKCKRPMTWKWRGEIMPATKSEYYLIQNQLEKEKFPPKKPSLPMRSFYELDKLEQATVEKERLGKFCRNAYNRKHNTRFEERTAVVCQRENAFYVDTVRAFRDRRYQYKDLTKVSKKRLDELISSENGDASEIKRANGMLVLYDSLQLAHKCILNSFYGYVMRKGARWYSMEMAGIVCSTGAAIIKYAREMIEQIGRPLELDTDGIWCILPASFPQGFEFQTNNPKKRNISFSYPGAMLNLMVQQYFTNDQYHDLVDPAKHTYRIRSENSIFFEVDGPYLAMILPASKEMNKKLKKRYAVFNRDRSLAELKGFEVKRNGELNLIKIFQSSVFESFLKGSSISEVYQHVAIVANYWLDLLYSRASTMPDEELFELISEKRCMSKKLEEYGKQKSTSISTARRLAEFLGDEMVKDAGLSFKFIISKKPEGQQVTDRAIPVAIFQAEESVKRFYLSKWLKSKDLQDFDIRNILDWDYYINRFSSNIQKIITIPAALQEVPNPVPRVAHPDWLHKILMEKDNRFKQQRITDIFQ-------TITPSQAAADKMKDIENCAPISKKKPTGVTSLKRARNKDTVDVYGVQLDMDNLPNHWRDILGDPVPKGNSKSQFIVWLEFHXXXXXXXXXXXDQSE----LSKENINPATVKRIKTVKKGIQSGISSFFTRSKQSILEDTWQIIQITDTNVSGIYRVWVLIGQEIHNMKLTVPRTFYVNTRIPKAPGENMYFKQVHKLLPRSRIVYHLYEYNLDETIFIKHRSDILSEFIRNEVEGIYELEVPLLLRVYAKLGCMCSIDRN---HFTDQQLSNNPSSFLLNELKFRSTAQHPYLSPNSIKTTFLFQQKSNRNEIIGWFDPCNNRAHLCLVEQSKPNPDKFQANVVQSWFSREREAFLSLKENESLISVVPEHVQFEVSSHKFEISAFKAINKLLVAHRNEVTTPTFIATKSKMTINELYSNLPALQEYPLVPITINETDVSFNVLDWQRIAIKSALQNFVKYEKLLAEMLERARYLHIPVGNMSKFTNDYRGISDSYDLFYGRFLMKNNFIWWCNDKSEPDLGKKENQDRRMMLVDNDVLNGMIYRNKPGCYPTTCVQLEMTYFPINTIIAMHKVMEIDGTNERLFESMIVPAKTIDQAMIQSKCNAAKRNLNLTSNTMYDDVTAAGPAFKILRNVILQWLDDVRNYKNPVADEHLMGFYKWMKNSRSLFYDPALFKSLQKLMRMVFFKLIEQLNNLGVEVIYGTLNKIVLCTKRTDLMDALVHVEYATKTVRNQDIFSQLDFQYVSGWDYLIWQDVSNYSGIKSDLESVTKEEHNSMVLEELSFVNMTNPSLSMGLSQSQNEDSFLTTEIADSSQIEMNWHLSRYLSPMSGVQLRLIEILQYFMLTNWKIVKDEYKLNRLAAKNDVAEEAVNTGTILGSDASLYPSSVQRMEDFLQNEMGYKLYLLVSQL-KDVPRMHNAVPLTTXXXXXXXXXXXSNKTPPLLPLKNKVSLHPIVDLIKTTCHILALDTSARYYVNDWKRNMFKLINFDAYSDQAKWRSPYSSDQSMGDAFRSDLIITVPEVICDNCNVTRDLDLCRD--LYQVRIKNSWWFVCPTCDFPYDRNVIQETLIDQVRCICESNVMQDLKCTKCTNGILETSLAGTENCVKCGNAIQVTQNAASLKEKIKIYADIGKHYDLPYLHMMTSWMLQ 7004
            +++ R +  D+ID  YGF+       +TGWL+NM   + +D++KRLVSA+ YYF++EDGS+FK  L ++PYFY+ TK GCE E+ ++L KK+   L  +E I KEDLDL NHL+GLK+ ++KL FH++DDL++VRKEI P +++N++   + + Y+ ML+    G      E    K   D M+N +D+REYDVPYHVRVSID  I +  WY++    +   P    IT R D+V+ P+P+VLA+DIETTKLPLKFPDA  DQIMMISYMIDG GYLI NREI+++DIEDFEFTP+PE+ GPF +FNEP+E   I+R+F+H++E KPNI VTYNGDFFDWPFVETRA  HG+ ML  IGF KDNQ EYKS   IHMDC +WV+RDSYLP+G+  LKA  KAKL Y+PVE+DPEEMC++A E+P+ LA YSVSDAVATYY+YMKYVHPFIFALCTIIPM+PDEVLRKGSGTLCE LLMV+A+++NIIFPNKQE+  N LT+DGHV++SETYVGGHVEA+ESGVFRSDIP +FK+ P    FL + ++ TL H +E EEK+ ++ V NF EV   I +KL  L+E   R ECP+IYHLDV AMYPNIIL+NRLQPSA+V+E TC ACDFN P A C+R MTW+WRGE MPA++SEY+ IQ QLE EKFPP  P  P R+F+EL + EQA  EK+RL  +CR AY + H TR EE+   +CQREN+FYVDTVRAFRDRRY++K L KV KK+L    + E+GDA+EIKR   M +LY+SLQLAHKCILNSFYGYVMRKGARWYSMEMAGIVC TGA II  ARE++EQIGRPLELDTDGIWC+LP SFP+ F  ++ N KK  ++ SYPGAMLN++V++ FTN QY +L DPA  TY  RSENSIFFEVDGPYLAMILPASKE  KKLKKRYAVFN D SLAELKGFEVKR GEL LIKIFQSSVFE+FLKGS++ EVY  VA VA+YWLD+LYS+A+ MPD ELFELISE R MS++LE+YG+QKSTSISTA+RLAEFLGD+MVKDAGLS +++IS+KPEG  VT+RAIP+AIFQAE  VKR YL KWLK+  LQD DIR+ILDWDYYI R  S IQKIITIPAALQ+V NPVPRV HPDWLHK L+EK++ +KQ+RI ++F        T    Q  + +  D+E+     + +P    S KR R     D  G   ++  L   WR++LG P P G +K + +VWL +HKKKW++Q   + + +    L   ++ P     I+  +    +G+ SF  R+ +SIL+  WQI+QI +++  G++R+W +IG ++H +KL +PR F+VN RIPK P E   +++V+++LPRS  VYHLYEY + E ++ +H ++I ++    ++EG+YE +VPL++R  ++LGC+C +++    H + ++      +F L  L+ +S AQ+ YL P SI+  +L+        + G F P   ++ + +V+  + N    Q   + + ++ E  A     + E L    PE   FEV +     + ++ I +LL+++++E   PT IA +S   +  L + +P L+E+PLVP+ I + D+S+ VLDWQR   +  +++++  +  L++  E ARY H+PVGN+    + +       DLF+ R L ++N + W +  + PDLG KE  D R+++  ++  +  I  N PGCY T CV+L++    +N+I+  H + +++G       SM +    + QA ++      +     +S   YD+       F+IL+++++ W+ ++  Y N  AD  +M FY+W+++  SL YDPAL ++L  +M+ +F +L+ +   LG  V+Y   N+I+LCTK+  + DA+ +VEY T+++ +++IF  L       W++L+W D +NY G+K  L S       S+   E+               Q  N D   + +  + S +E NW++ +YL   +  Q   + I+  +++  +  +++E + N          +         +D    P  +   +D++ NE+    + +  ++ K V    +A               E ++  P+LP  +    +P ++ IK  C +LALD++    VN  KR++ +L++   +S+ A++R P  S               +PE+IC +CN  RDLDLC+D  + Q       W VC  C   YD + I+  L++ ++    +  +QDL C KC  G+ E ++    N   C     +T +   L E+I ++ +I +HY++ +L     W++Q
Sbjct:   48 KRLERSQWTDKIDAQYGFERIREPGEKTGWLLNMHPNEILDEDKRLVSAVDYYFIQEDGSRFKVALPYKPYFYVATKKGCEREVSSFLSKKFQGKLAKLETIPKEDLDLPNHLVGLKRGYIKLSFHSVDDLIKVRKEISPAVRKNKERDHASDTYTAMLSSALTGNNMGAEEEGPSKKISDQMENIVDMREYDVPYHVRVSIDLKIHVAHWYNIRYRGSSSPPE---ITRRDDLVERPDPVVLAFDIETTKLPLKFPDAETDQIMMISYMIDGQGYLITNREIVSEDIEDFEFTPKPEYEGPFCIFNEPDEAHLIQRWFEHMQETKPNIIVTYNGDFFDWPFVETRASVHGMSMLQEIGFQKDNQGEYKSPPCIHMDCLRWVKRDSYLPVGSHNLKAAAKAKLGYDPVELDPEEMCRMATEEPQVLATYSVSDAVATYYMYMKYVHPFIFALCTIIPMEPDEVLRKGSGTLCEALLMVQAYHANIIFPNKQEAVFNKLTSDGHVLDSETYVGGHVEALESGVFRSDIPCRFKMNPAAFDFLLQRVELTLRHAIEEEEKIPLEQVTNFQEVCEEIKKKLNSLKEVPNRIECPLIYHLDVGAMYPNIILTNRLQPSAMVDEVTCAACDFNKPGATCQRQMTWQWRGEFMPASRSEYHRIQQQLESEKFPPLFPGKPPRAFHELTREEQAKYEKKRLADYCRKAYKKIHVTRLEEKVTTICQRENSFYVDTVRAFRDRRYEFKGLHKVWKKKLSS--ACESGDAAEIKRCKNMEILYESLQLAHKCILNSFYGYVMRKGARWYSMEMAGIVCYTGANIITQARELVEQIGRPLELDTDGIWCVLPNSFPENFVIKSTNAKKPKVTISYPGAMLNILVKEGFTNHQYQELSDPATLTYITRSENSIFFEVDGPYLAMILPASKEEGKKLKKRYAVFNEDGSLAELKGFEVKRRGELQLIKIFQSSVFEAFLKGSTLEEVYASVAKVADYWLDVLYSKAANMPDAELFELISENRSMSRRLEDYGEQKSTSISTAKRLAEFLGDQMVKDAGLSCRYVISRKPEGSPVTERAIPLAIFQAEVGVKRHYLRKWLKNPSLQDLDIRSILDWDYYIERLGSAIQKIITIPAALQQVKNPVPRVRHPDWLHKKLLEKNDIYKQKRINELFTSEGKRQITAQMQQPDSSQTPDMEDFGIGKRLQPAVPISTKRKRVPTAEDSQGDSQNL-ALTQSWREVLGQPPPLGTTKEERLVWLRYHKKKWELQARQRKERQKKRRLEDGDVAPGAGGVIRETQA---AGLGSFLRRTARSILDMPWQIVQIGESSQPGLFRLWAVIGNDLHCIKLNIPRVFFVNQRIPK-PEEGAVYRKVNRILPRSNPVYHLYEYTVPEDMYQEHINEINADLSAPDIEGVYETQVPLIMRAVSQLGCVCMVNKQLVRHLSGRE----ADTFDLEHLEMKSLAQYSYLEPGSIRHIYLYHNSQGHKALFGLFIPSQRKSAVFVVDTVRSN----QMPNLSNMYTAEHTAMQERVDPELL---PPEKHIFEVRAETDLKTVYRGIQRLLLSYKDERRGPTLIAVQSNWNLRRLAAGMPVLEEFPLVPVRITD-DISYGVLDWQRHGARRMIRHYLNLDSCLSQAFEMARYYHLPVGNLPDDVSTF-----GSDLFFSRHLRRHNHLLWLSPSARPDLGGKEADDNRLVMEFDEKASVEI--NNPGCYNTVCVELDIQSLAVNSILQSHHINDLEGAG-----SMGISFDVLQQASLEDMVTGNQ----ASSVASYDETALCSNTFRILKSMVVGWVKEITQYHNVYADNQVMHFYRWLRSPSSLLYDPALHRTLHNMMKKLFLQLVAEFKRLGSSVVYANFNRIILCTKKRRVEDAVAYVEYITQSIHSREIFHSLTISVSRCWEFLLWMDPANYGGVKGKLPS-------SVHYGEVRPQGDDGSEDEEEDDQPVNSDDEQSEDQVEES-LENNWNIVQYLPQAASCQSYFLMIVSAYIVAVYHSMREEMRRNAPGNTPIKRRQNSQVSQEANADGGAMPGLITFSQDYVANELTQNFFTITQKIQKKVTGTRHAT--------------EPSEMFPILPGSHLPLNNPALEFIKYVCEVLALDSNITNQVNKLKRDLLRLVDVGEFSEDAQFRDPCRS-------------YILPEIICRSCNFCRDLDLCKDPAINQDGSVLPQW-VCTNCQAEYDSDGIEMALVEALQKKMMAFTLQDLVCMKC-KGVKEANMPVYCN---CAGDFTLTISVKVLLEQINVFRNIAQHYNMAHLLETIVWIMQ 2289
[Close]
BLAST of DNA polymerase epsilon catalytic subunit vs. Ensembl Xenopus
Match: prmt8 (protein arginine methyltransferase 8 [Source:Xenbase;Acc:XB-GENE-6037618])

HSP 1 Score: 2133.61 bits (5527), Expect = 0.000e+0
Identity = 1074/2277 (47.17%), Postives = 1499/2277 (65.83%), Query Frame = 3 
Query:  102 EKILRLKKNDQIDLVYGFDLHSAIKIRTGWLINMKTTDAIDDNKRLVSAMSYYFLEEDGSKFKSTLIFQPYFYIVTKLGCESEIQTYLMKKYSACLHNIEIIEKEDLDLDNHXXXXXXXXXXXXXHTIDDLVRVRKEIMPKIKQNQKNQESDNDYSKMLTEHFQGEK--KYEYNARKSALDIMDNAIDIREYDVPYHVRVSIDTAIFIGKWYDVHGSMNIKGPNSTHITPRSDIVDHPEPIVLAYDIETTKLPLKFPDATFDQIMMISYMIDGMGYLICNREIIADDIEDFEFTPRPEFPGPFSVFNEPNEKRTIERFFDHIREVKPNIFVTYNGDFFDWPFVETRAVKHGLDMLDYIGFSKDNQNEYKSRSAIHMDCFKWVQRDSYLPIGAQGLKAVCKAKLRYNPVEVDPEEMCKVAREDPRTLANYSVSDAVATYYLYMKYVHPFIFALCTIIPMDPDEVLRKGSGTLCECLLMVEAFNSNIIFPNKQESKLNPLTNDGHVIESETYVGGHVEAIESGVFRSDIPTKFKIVPEMCKFLRKNLKETLVHVLEVEEKVTVDSVLNFDEVYNAIDEKLEDLEETNIRFECPVIYHLDVAAMYPNIILSNRLQPSALVNEKTCGACDFNVPNAKCKRPMTWKWRGEIMPATKSEYYLIQNQLEKEKFPPKKPSLPMRSFYELDKLEQATVEKERLGKFCRNAYNRKHNTRFEERTAVVCQRENAFYVDTVRAFRDRRYQYKDLTKVSKKRLDELISSENGDASEIKRANGMLVLYDSLQLAHKCILNSFYGYVMRKGARWYSMEMAGIVCSTGAAIIKYAREMIEQIGRPLELDTDGIWCILPASFPQGFEFQTNNPKKRNISFSYPGAMLNLMVQQYFTNDQYHDLVDPAKHTYRIRSENSIFFEVDGPYLAMILPASKEMNKKLKKRYAVFNRDRSLAELKGFEVKRNGELNLIKIFQSSVFESFLKGSSISEVYQHVAIVANYWLDLLYSRASTMPDEELFELISEKRCMSKKLEEYGKQKSTSISTARRLAEFLGDEMVKDAGLSFKFIISKKPEGQQVTDRAIPVAIFQAEESVKRFYLSKWLKSKDLQDFDIRNILDWDYYINRFSSNIQKIITIPAALQEVPNPVPRVAHPDWLHKILMEKDNRFKQQRITDIFQ-------TITPSQAAADKMKDIENCAPISKKKPTGVTSLKRARNKDTVDVYGVQLDMDNLPNHWRDILGDPVPKGNSKSQFIVWLEFHXXXXXXXXXXXDQSE----LSKENINPATVKRIKTVKKGIQSGISSFFTRSKQSILEDTWQIIQITDTNVSGIYRVWVLIGQEIHNMKLTVPRTFYVNTRIPKAPGENMYFKQVHKLLPRSRIVYHLYEYNLDETIFIKHRSDILSEFIRNEVEGIYELEVPLLLRVYAKLGCMCSIDRN---HFTDQQLSNNPSSFLLNELKFRSTAQHPYLSPNSIKTTFLFQQKSNRNEIIGWFDPCNNRAHLCLVEQSKPNPDKFQANVVQSWFSREREAFLSLKENESLISVVPEHVQFEVSSHKFEISAFKAINKLLVAHRNEVTTPTFIATKSKMTINELYSNLPALQEYPLVPITINETDVSFNVLDWQRIAIKSALQNFVKYEKLLAEMLERARYLHIPVGNMSKFTNDYRGISDSYDLFYGRFLMKNNFIWWCNDKSEPDLGKKENQDRRMMLVDNDVLNGMIYRNKPGCYPTTCVQLEMTYFPINTIIAMHKVMEIDGTNERLFESMIVPAKTIDQAMIQSKCNAAKRNLNLTSNTMYDDVTAAGPAFKILRNVILQWLDDVRNYKNPVADEHLMGFYKWMKNSRSLFYDPALFKSLQKLMRMVFFKLIEQLNNLGVEVIYGTLNKIVLCTKRTDLMDALVHVEYATKTVRNQDIFSQLDFQYVSGWDYLIWQDVSNYSGIKSDLESVTKEEHNSMVLEELSFVNMTNPSLSMGLSQSQNEDSFLTTEIADSSQIEMNWHLSRYLSPMSGVQLRLIEILQYFMLTNWKIVKDEYKLNRLAAKNDVAEEAVNTGTILGSDASLYPSSVQRMEDFLQNEMGYKLYLLVSQL-KDVPRMHNAVPLTTXXXXXXXXXXXSNKTPPLLPLKNKVSLHPIVDLIKTTCHILALDTSARYYVNDWKRNMFKLINFDAYSDQAKWRSPYSSDQSMGDAFRSDLIITVPEVICDNCNVTRDLDLCRD--LYQVRIKNSWWFVCPTCDFPYDRNVIQETLIDQVRCICESNVMQDLKCTKCTNGILETSLAGTENCV 6875
            +++ R +  D+ID  YGF+       +TGWL+NM   + +D++KRLVSA+ YYF++EDGS+FK  L ++PYFY+ TK GCE E+ ++L KK+   L  +E I KEDLDL NHL+GLK+ ++KL FH++DDL++VRKEI P +++N++   + + Y+ ML+    G      E    K   D M+N +D+REYDVPYHVRVSID  I +  WY++    +   P    IT R D+V+ P+P+VLA+DIETTKLPLKFPDA  DQIMMISYMIDG GYLI NREI+++DIEDFEFTP+PE+ GPF +FNEP+E   I+R+F+H++E KPNI VTYNGDFFDWPFVETRA  HG+ ML  IGF KDNQ EYKS   IHMDC +WV+RDSYLP+G+  LKA  KAKL Y+PVE+DPEEMC++A E+P+ LA YSVSDAVATYY+YMKYVHPFIFALCTIIPM+PDEVLRKGSGTLCE LLMV+A+++NIIFPNKQE+  N LT+DGHV++SETYVGGHVEA+ESGVFRSDIP +FK+ P    FL + ++ TL H +E EEK+ ++ V NF EV   I +KL  L+E   R ECP+IYHLDV AMYPNIIL+NRLQPSA+V+E TC ACDFN P A C+R MTW+WRGE MPA++SEY+ IQ QLE EKFPP  P  P R+F+EL + EQA  EK+RL  +CR AY + H TR EE+   +CQREN+FYVDTVRAFRDRRY++K L KV KK+L    + E+GDA+EIKR   M +LY+SLQLAHKCILNSFYGYVMRKGARWYSMEMAGIVC TGA II  ARE++EQIGRPLELDTDGIWC+LP SFP+ F  ++ N KK  ++ SYPGAMLN++V++ FTN QY +L DPA  TY  RSENSIFFEVDGPYLAMILPASKE  KKLKKRYAVFN D SLAELKGFEVKR GEL LIKIFQSSVFE+FLKGS++ EVY  VA VA+YWLD+LYS+A+ MPD ELFELISE R MS++LE+YG+QKSTSISTA+RLAEFLGD+MVKDAGLS +++IS+KPEG  VT+RAIP+AIFQAE  VKR YL KWLK+  LQD DIR+ILDWDYYI R  S IQKIITIPAALQ+V NPVPRV HPDWLHK L+EK++ +KQ+RI ++F        T    Q  + +  D+E+     + +P    S KR R     D  G   ++  L   WR++LG P P G +K + +VWL +HKKKW++Q   + + +    L   ++ P     I+  +    +G+ SF  R+ +SIL+  WQI+QI +++  G++R+W +IG ++H +KL +PR F+VN RIPK P E   +++V+++LPRS  VYHLYEY + E ++ +H ++I ++    ++EG+YE +VPL++R  ++LGC+C +++    H + ++      +F L  L+ +S AQ+ YL P SI+  +L+        + G F P   ++ + +V+  + N    Q   + + ++ E  A     + E L    PE   FEV +     + ++ I +LL+++++E   PT IA +S   +  L + +P L+E+PLVP+ I + D+S+ VLDWQR   +  +++++  +  L++  E ARY H+PVGN+    + +       DLF+ R L ++N + W +  + PDLG KE  D R+++  ++  +  I  N PGCY T CV+L++    +N+I+  H + +++G       SM +    + QA ++      +     +S   YD+       F+IL+++++ W+ ++  Y N  AD  +M FY+W+++  SL YDPAL ++L  +M+ +F +L+ +   LG  V+Y   N+I+LCTK+  + DA+ +VEY T+++ +++IF  L       W++L+W D +NY G+K  L S      ++   + L               Q  N D   + +  + S +E NW++ +YL   +  Q   + I+  +++  +  +++E + N          +         +D    P  +   +D++ NE+    + +  ++ K V    +A               E ++  P+LP  +    +P ++ IK  C +LALD++    VN  KR++ +L++   +S+ A++R P  S               +PE+IC +CN  RDLDLC+D  + Q       W VC  C   YD + I+  L++ ++    +  +QDL C KC  G+ E ++    NC 
Sbjct:   31 KRLERSQWTDKIDAQYGFERIREPGEKTGWLLNMHPNEILDEDKRLVSAVDYYFIQEDGSRFKVALPYKPYFYVATKKGCEREVSSFLSKKFQGKLAKLETIPKEDLDLPNHLVGLKRGYIKLSFHSVDDLIKVRKEISPAVRKNKERDHASDTYTAMLSSALTGNNMGAEEEGPSKKISDQMENIVDMREYDVPYHVRVSIDLKIHVAHWYNIRYRGSSSPP---EITRRDDLVERPDPVVLAFDIETTKLPLKFPDAETDQIMMISYMIDGQGYLITNREIVSEDIEDFEFTPKPEYEGPFCIFNEPDEAHLIQRWFEHMQETKPNIIVTYNGDFFDWPFVETRASVHGMSMLQEIGFQKDNQGEYKSPPCIHMDCLRWVKRDSYLPVGSHNLKAAAKAKLGYDPVELDPEEMCRMATEEPQVLATYSVSDAVATYYMYMKYVHPFIFALCTIIPMEPDEVLRKGSGTLCEALLMVQAYHANIIFPNKQEAVFNKLTSDGHVLDSETYVGGHVEALESGVFRSDIPCRFKMNPAAFDFLLQRVELTLRHAIEEEEKIPLEQVTNFQEVCEEIKKKLNSLKEVPNRIECPLIYHLDVGAMYPNIILTNRLQPSAMVDEVTCAACDFNKPGATCQRQMTWQWRGEFMPASRSEYHRIQQQLESEKFPPLFPGKPPRAFHELTREEQAKYEKKRLADYCRKAYKKIHVTRLEEKVTTICQRENSFYVDTVRAFRDRRYEFKGLHKVWKKKLSS--ACESGDAAEIKRCKNMEILYESLQLAHKCILNSFYGYVMRKGARWYSMEMAGIVCYTGANIITQARELVEQIGRPLELDTDGIWCVLPNSFPENFVIKSTNAKKPKVTISYPGAMLNILVKEGFTNHQYQELSDPATLTYITRSENSIFFEVDGPYLAMILPASKEEGKKLKKRYAVFNEDGSLAELKGFEVKRRGELQLIKIFQSSVFEAFLKGSTLEEVYASVAKVADYWLDVLYSKAANMPDAELFELISENRSMSRRLEDYGEQKSTSISTAKRLAEFLGDQMVKDAGLSCRYVISRKPEGSPVTERAIPLAIFQAEVGVKRHYLRKWLKNPSLQDLDIRSILDWDYYIERLGSAIQKIITIPAALQQVKNPVPRVRHPDWLHKKLLEKNDIYKQKRINELFTSEGKRQITAQMQQPDSSQTPDMEDFGIGKRLQPAVPISTKRKRVPTAEDSQGDSQNL-ALTQSWREVLGQPPPLGTTKEERLVWLRYHKKKWELQARQRKERQKKRRLEDGDVAPGAGGVIRETQA---AGLGSFLRRTARSILDMPWQIVQIGESSQPGLFRLWAVIGNDLHCIKLNIPRVFFVNQRIPK-PEEGAVYRKVNRILPRSNPVYHLYEYTVPEDMYQEHINEINADLSAPDIEGVYETQVPLIMRAVSQLGCVCMVNKQLVRHLSGRE----ADTFDLEHLEMKSLAQYSYLEPGSIRHIYLYHNSQGHKALFGLFIPSQRKSAVFVVDTVRSN----QMPNLSNMYTAEHTAMQERVDPELL---PPEKHIFEVRAETDLKTVYRGIQRLLLSYKDERRGPTLIAVQSNWNLRRLAAGMPVLEEFPLVPVRITD-DISYGVLDWQRHGARRMIRHYLNLDSCLSQAFEMARYYHLPVGNLPDDVSTF-----GSDLFFSRHLRRHNHLLWLSPSARPDLGGKEADDNRLVMEFDEKASVEI--NNPGCYNTVCVELDIQSLAVNSILQSHHINDLEGAG-----SMGISFDVLQQASLEDMVTGNQ----ASSVASYDETALCSNTFRILKSMVVGWVKEITQYHNVYADNQVMHFYRWLRSPSSLLYDPALHRTLHNMMKKLFLQLVAEFKRLGSSVVYANFNRIILCTKKRRVEDAVAYVEYITQSIHSREIFHSLTISVSRCWEFLLWMDPANYGGVKGKLPSSVHYGESAKKKKALDGEGDDGSEDEEEDDQPVNSDDEQSEDQVEES-LENNWNIVQYLPQAASCQSYFLMIVSAYIVAVYHSMREEMRRNAPGNTPIKRRQNSQVSQEANADGGAMPGLITFSQDYVANELTQNFFTITQKIQKKVTGTRHAT--------------EPSEMFPILPGSHLPLNNPALEFIKYVCEVLALDSNITNQVNKLKRDLLRLVDVGEFSEDAQFRDPCRS-------------YILPEIICRSCNFCRDLDLCKDPAINQDGSVLPQW-VCTNCQAEYDSDGIEMALVEALQKKMMAFTLQDLVCMKC-KGVKEANMPVYCNCA 2239
[Close]
BLAST of DNA polymerase epsilon catalytic subunit vs. Ensembl Xenopus
Match: prmt8 (protein arginine methyltransferase 8 [Source:Xenbase;Acc:XB-GENE-6037618])

HSP 1 Score: 2093.16 bits (5422), Expect = 0.000e+0
Identity = 1069/2320 (46.08%), Postives = 1497/2320 (64.53%), Query Frame = 3 
Query:  102 EKILRLKKNDQIDLVYGFDLHSAIKIRTGWLINMKTTDAIDDNKRLVSAMSYYFLEEDGSKFKSTLIFQPYFYIVTKLGCESEIQTYLMKKYSACLHNIEIIEKEDLDLDNHXXXXXXXXXXXXXHTIDDLVRVRKEIMPKIKQNQKNQESDNDYSKMLTEHFQGEK--KYEYNARKSALDIMDNAIDIREYDVPYHVRVSIDTAIFIGKWYDVHGSMNIKGPNSTHITPRSDIVDHPEPIVLAYDIETTKLPLKFPDATFDQIMMISYMIDGMGYLICNREIIADDIEDFEFTPRPEFPGPFSVFNEPNEKRTIERFFDHIREVKPNIFVTYNGDFFDWPFVETRAVKHGLDMLDYIGFSKDNQNEYKSRSAIHMDCFKWVQRDSYLPIGAQGLKAVCKAKLRYNPVEVDPEEMCKVAREDPRTLANYSVSDAVATYYLYMKYVHPFIFALCTIIPMDPDEVLRKGSGTLCECLLMVEAFNSNIIFPNKQESKLNPLTNDGHVIESETYVGGHVEAIESGVFRSDIPTKFKIVPEMCKFLRKNLKETLVHVLEVEEKVTVDSVLNFDEVYNAIDEKLEDLEETNIRFECPVIYHLDVAAMYPNIILSNRLQPSALVNEKTCGACDFNVPNAKCKRPMTWKWRGEIMPATKSEYYLIQNQLEKEKFPPKKPSLPMRSFYELDKLEQATVEKERLGKFCRNAYNRKHNTRFEERTAVVCQRENAFYVDTVRAFRDRRYQYKDLTKVSKKRLDELISSENGDASEIKRANGMLVLYDSLQLAHKCILNSFYGYVMRKGARWYSMEMAGIVCSTGAAIIKYAREMIEQIGRPLELDTDGIWCILPASFPQGFEFQTNNPKKRNISFSYPGAMLNLMVQQYFTNDQYHDLVDPAKHTYRIRSENSIFFEVDGPYLAMILPASKEMNKKLKKRYAVFNRDRSLAELKGFEVKRNGELNLIKIFQSSVFESFLKGSSISEVYQHVAIVANYWLDLLYSRASTMPDEELFELISEKRCMSKKLEEYGKQKSTSISTARRLAEFLGDEMVKDAGLSFKFIISKKPEGQQVTDRAIPVAIFQAEESVKRFYLSKWLKSKDLQDFDIRNILDWDYYINRFSSNIQKIITIPAALQEVPNPVPRVAHPDWLHKILMEKDNRFKQQRITDIFQ-------TITPSQAAADKMKDIENCAPISKKKPTGVTSLKRARNKDTVDVYGVQLDMDNLPNHWRDILGDPVPKGNSKSQFIVWLEFHXXXXXXXXXXXDQSE----LSKENINPATVKRIKTVKKGIQSGISSFFTRSKQSILEDTWQIIQITDTNVSGIYRVWVLIGQEIHNMKLTVPRTFYVNTRIPKAPGENMYFKQVHKLLPRSRIVYHLYEYNLDETIFIKHRSDILSEFIRNEVEGIYELEVPLLLRVYAKLGCMCSIDRN---HFTDQQLSNNPSSFLLNELKFRSTAQHPYLSPNSIKTTFLFQQKSNRNEIIGWFDPCNNRAHLCLVEQSKPNPDKFQANVVQSWFSREREAFLSLKENESLISVVPEHVQFEVSSHKFEISAFKAINKLLVAHRNEVTTPTFIATKSKMTINELYSNLPALQEYPLVPITINETDVSFNVLDWQRIAIKSALQNFVKYEKLLAEMLERARYLHIPVGNMSKFTNDYRGISDSYDLFYGRFLMKNNFIWWCNDKSEPDLGKKENQDRRMMLVDNDVLNGMIYRNKPGCYPTTCVQLEMTYFPINTIIAMHKVMEIDGTNERLFESMIVPAKTIDQAMIQSKCNAAKRNLNLTSNTMYDDVTAAGPAFKILRNVILQWLDDVRNYKNPVADEHLMGFYKWMKNSRSLFYDPALFKSLQKLMRMVFFKLIEQLNNLGVEVIYGTLNKIVLCTKRTDLMDALVHVEYATKTVRNQDIFSQLDFQYVSGWDYLIWQDVSNYSGIKSDLESVTKEEHNSMVLEELSFVNMTNPSLSMGLSQSQNEDSFLTTEIADSSQIEMNWHLSRYLSPMSGVQLRLIEILQYFMLTNWKIVKDEYKLNRLAAKNDVAEEAVNTGTILGSDASLYPSSVQRMEDFLQNEMGYKLYLLVSQL-KDVPRMHNAVPLTTXXXXXXXXXXXSNKTPPLLPLKNKVSLHPIVDLIKTTCHILALDTSARYYVNDWKRNMFKLINFDAYSDQAKWRSPYSSDQSMGDAFRSDLIITVPEVICDNCNVTRDLDLCRD--LYQVRIKNSWWFVCPTCDFPYDRNVIQETLIDQVRCICESNVMQDLKCTKCTNGILETSLAGTENCVKCGNAIQVTQNAASLKEKIKIYADIGKHYDLPYLHMMTSWMLQ 7004
            +++ R +  D+ID  YGF+       +TGWL+NM                               L ++PYFY+ TK GCE E+ ++L KK+   L  +E I KEDLDL NHL+GLK+ ++KL FH++DDL++VRKEI P +++N++   + + Y+ ML+    G      E    K   D M+N +D+REYDVPYHVRVSID  I +  WY++    +   P    IT R D+V+ P+P+VLA+DIETTKLPLKFPDA  DQIMMISYMIDG GYLI NREI+++DIEDFEFTP+PE+ GPF +FNEP+E   I+R+F+H++E KPNI VTYNGDFFDWPFVETRA  HG+ ML  IGF KDNQ EYKS   IHMDC +WV+RDSYLP+G+  LKA  KAKL Y+PVE+DPEEMC++A E+P+ LA YSVSDAVATYY+YMKYVHPFIFALCTIIPM+PDEVLRKGSGTLCE LLMV+A+++NIIFPNKQE+  N LT+DGHV++SETYVGGHVEA+ESGVFRSDIP +FK+ P    FL + ++ TL H +E EEK+ ++ V NF EV   I +KL  L+E   R ECP+IYHLDV AMYPNIIL+NRLQPSA+V+E TC ACDFN P A C+R MTW+WRGE MPA++SEY+ IQ QLE EKFPP  P  P R+F+EL + EQA  EK+RL  +CR AY + H TR EE+   +CQREN+FYVDTVRAFRDRRY++K L KV KK+L    + E+GDA+EIKR   M +LY+SLQLAHKCILNSFYGYVMRKGARWYSMEMAGIVC TGA II  ARE++EQIGRPLELDTDGIWC+LP SFP+ F  ++ N KK  ++ SYPGAMLN++V++ FTN QY +L DPA  TY  RSENSIFFEVDGPYLAMILPASKE  KKLKKRYAVFN D SLAELKGFEVKR GEL LIKIFQSSVFE+FLKGS++ EVY  VA VA+YWLD+LYS+A+ MPD ELFELISE R MS++LE+YG+QKSTSISTA+RLAEFLGD+MVKDAGLS +++IS+KPEG  VT+RAIP+AIFQAE  VKR YL KWLK+  LQD DIR+ILDWDYYI R  S IQKIITIPAALQ+V NPVPRV HPDWLHK L+EK++ +KQ+RI ++F        T    Q  + +  D+E+     + +P    S KR R     D  G   ++  L   WR++LG P P G +K + +VWL +HKKKW++Q   + + +    L   ++ P     I+  +    +G+ SF  R+ +SIL+  WQI+QI +++  G++R+W +IG ++H +KL +PR F+VN RIPK P E   +++V+++LPRS  VYHLYEY + E ++ +H ++I ++    ++EG+YE +VPL++R  ++LGC+C +++    H + ++      +F L  L+ +S AQ+ YL P SI+  +L+        + G F P   ++ + +V+  + N    Q   + + ++ E  A     + E L    PE   FEV +     + ++ I +LL+++++E   PT IA +S   +  L + +P L+E+PLVP+ I + D+S+ VLDWQR   +  +++++  +  L++  E ARY H+PVGN+    + +       DLF+ R L ++N + W +  + PDLG KE  D R+++  ++  +  I  N PGCY T CV+L++    +N+I+  H + +++G       SM +    + QA ++      +     +S   YD+       F+IL+++++ W+ ++  Y N  AD  +M FY+W+++  SL YDPAL ++L  +M+ +F +L+ +   LG  V+Y   N+I+LCTK+  + DA+ +VEY T+++ +++IF  L       W++L+W D +NY G+K  L S     +               P  S      Q+ED     ++ +S  +E NW++ +YL   +  Q   + I+  +++  +  +++E + N          +         +D    P  +   +D++ NE+    + +  ++ K V    +A               E ++  P+LP  +    +P ++ IK  C +LALD++    VN  KR++ +L++   +S+ A++R P  S               +PE+IC +CN  RDLDLC+D  + Q       W VC  C   YD + I+  L++ ++    +  +QDL C KC  G+ E ++    N   C     +T +   L E+I ++ +I +HY++ +L     W++Q
Sbjct:   20 KRLERSQWTDKIDAQYGFERIREPGEKTGWLLNMHPV---------------------------ALPYKPYFYVATKKGCEREVSSFLSKKFQGKLAKLETIPKEDLDLPNHLVGLKRGYIKLSFHSVDDLIKVRKEISPAVRKNKERDHASDTYTAMLSSALTGNNMGAEEEGPSKKISDQMENIVDMREYDVPYHVRVSIDLKIHVAHWYNIRYRGSSSPPE---ITRRDDLVERPDPVVLAFDIETTKLPLKFPDAETDQIMMISYMIDGQGYLITNREIVSEDIEDFEFTPKPEYEGPFCIFNEPDEAHLIQRWFEHMQETKPNIIVTYNGDFFDWPFVETRASVHGMSMLQEIGFQKDNQGEYKSPPCIHMDCLRWVKRDSYLPVGSHNLKAAAKAKLGYDPVELDPEEMCRMATEEPQVLATYSVSDAVATYYMYMKYVHPFIFALCTIIPMEPDEVLRKGSGTLCEALLMVQAYHANIIFPNKQEAVFNKLTSDGHVLDSETYVGGHVEALESGVFRSDIPCRFKMNPAAFDFLLQRVELTLRHAIEEEEKIPLEQVTNFQEVCEEIKKKLNSLKEVPNRIECPLIYHLDVGAMYPNIILTNRLQPSAMVDEVTCAACDFNKPGATCQRQMTWQWRGEFMPASRSEYHRIQQQLESEKFPPLFPGKPPRAFHELTREEQAKYEKKRLADYCRKAYKKIHVTRLEEKVTTICQRENSFYVDTVRAFRDRRYEFKGLHKVWKKKLSS--ACESGDAAEIKRCKNMEILYESLQLAHKCILNSFYGYVMRKGARWYSMEMAGIVCYTGANIITQARELVEQIGRPLELDTDGIWCVLPNSFPENFVIKSTNAKKPKVTISYPGAMLNILVKEGFTNHQYQELSDPATLTYITRSENSIFFEVDGPYLAMILPASKEEGKKLKKRYAVFNEDGSLAELKGFEVKRRGELQLIKIFQSSVFEAFLKGSTLEEVYASVAKVADYWLDVLYSKAANMPDAELFELISENRSMSRRLEDYGEQKSTSISTAKRLAEFLGDQMVKDAGLSCRYVISRKPEGSPVTERAIPLAIFQAEVGVKRHYLRKWLKNPSLQDLDIRSILDWDYYIERLGSAIQKIITIPAALQQVKNPVPRVRHPDWLHKKLLEKNDIYKQKRINELFTSEGKRQITAQMQQPDSSQTPDMEDFGIGKRLQPAVPISTKRKRVPTAEDSQGDSQNL-ALTQSWREVLGQPPPLGTTKEERLVWLRYHKKKWELQARQRKERQKKRRLEDGDVAPGAGGVIRETQA---AGLGSFLRRTARSILDMPWQIVQIGESSQPGLFRLWAVIGNDLHCIKLNIPRVFFVNQRIPK-PEEGAVYRKVNRILPRSNPVYHLYEYTVPEDMYQEHINEINADLSAPDIEGVYETQVPLIMRAVSQLGCVCMVNKQLVRHLSGRE----ADTFDLEHLEMKSLAQYSYLEPGSIRHIYLYHNSQGHKALFGLFIPSQRKSAVFVVDTVRSN----QMPNLSNMYTAEHTAMQERVDPELL---PPEKHIFEVRAETDLKTVYRGIQRLLLSYKDERRGPTLIAVQSNWNLRRLAAGMPVLEEFPLVPVRITD-DISYGVLDWQRHGARRMIRHYLNLDSCLSQAFEMARYYHLPVGNLPDDVSTF-----GSDLFFSRHLRRHNHLLWLSPSARPDLGGKEADDNRLVMEFDEKASVEI--NNPGCYNTVCVELDIQSLAVNSILQSHHINDLEGAG-----SMGISFDVLQQASLEDMVTGNQ----ASSVASYDETALCSNTFRILKSMVVGWVKEITQYHNVYADNQVMHFYRWLRSPSSLLYDPALHRTLHNMMKKLFLQLVAEFKRLGSSVVYANFNRIILCTKKRRVEDAVAYVEYITQSIHSREIFHSLTISVSRCWEFLLWMDPANYGGVKGKLPSSV--HYGEGDDGSEDEEEDDQPVNS---DDEQSED-----QVEES--LENNWNIVQYLPQAASCQSYFLMIVSAYIVAVYHSMREEMRRNAPGNTPIKRRQNSQVSQEANADGGAMPGLITFSQDYVANELTQNFFTITQKIQKKVTGTRHAT--------------EPSEMFPILPGSHLPLNNPALEFIKYVCEVLALDSNITNQVNKLKRDLLRLVDVGEFSEDAQFRDPCRS-------------YILPEIICRSCNFCRDLDLCKDPAINQDGSVLPQW-VCTNCQAEYDSDGIEMALVEALQKKMMAFTLQDLVCMKC-KGVKEANMPVYCN---CAGDFTLTISVKVLLEQINVFRNIAQHYNMAHLLETIVWIMQ 2230
[Close]
BLAST of DNA polymerase epsilon catalytic subunit vs. Ensembl Mouse
Match: Pole (polymerase (DNA directed), epsilon [Source:MGI Symbol;Acc:MGI:1196391])

HSP 1 Score: 2129.75 bits (5517), Expect = 0.000e+0
Identity = 1099/2337 (47.03%), Postives = 1523/2337 (65.17%), Query Frame = 3 
Query:  102 EKILRLKKNDQIDLVYGFDLHSAIKIRTGWLINMKTTDAIDDNKRLVSAMSYYFLEEDGSKFKSTLIFQPYFYIVTKLGCESEIQTYLMKKYSACLHNIEIIEKEDLDLDNHXXXXXXXXXXXXXHTIDDLVRVRKEIMPKIKQNQKNQESDNDYSKMLTEHFQGEKKY--EYNARKSALDIMDNAIDIREYDVPYHVRVSIDTAIFIGKWYDVHGSMNIKGPNSTHITPRSDIVDHPEPIVLAYDIETTKLPLKFPDATFDQIMMISYMIDGMGYLICNREIIADDIEDFEFTPRPEFPGPFSVFNEPNEKRTIERFFDHIREVKPNIFVTYNGDFFDWPFVETRAVKHGLDMLDYIGFSKDNQNEYKSRSAIHMDCFKWVQRDSYLPIGAQGLKAVCKAKLRYNPVEVDPEEMCKVAREDPRTLANYSVSDAVATYYLYMKYVHPFIFALCTIIPMDPDEVLRKGSGTLCECLLMVEAFNSNIIFPNKQESKLNPLTNDGHVIESETYVGGHVEAIESGVFRSDIPTKFKIVPEMCKFLRKNLKETLVHVLEVEEKVTVDSVLNFDEVYNAIDEKLEDLEETNIRFECPVIYHLDVAAMYPNIILSNRLQPSALVNEKTCGACDFNVPNAKCKRPMTWKWRGEIMPATKSEYYLIQNQLEKEKFPPKKPSLPMRSFYELDKLEQATVEKERLGKFCRNAYNRKHNTRFEERTAVVCQRENAFYVDTVRAFRDRRYQYKDLTKVSKKRLDELISSENGDASEIKRANGMLVLYDSLQLAHKCILNSFYGYVMRKGARWYSMEMAGIVCSTGAAIIKYAREMIEQIGRPLELDTDGIWCILPASFPQGFEFQTNNPKKRNISFSYPGAMLNLMVQQYFTNDQYHDLVDPAKHTYRIRSENSIFFEVDGPYLAMILPASKEMNKKLKKRYAVFNRDRSLAELKGFEVKRNGELNLIKIFQSSVFESFLKGSSISEVYQHVAIVANYWLDLLYSRASTMPDEELFELISEKRCMSKKLEEYGKQKSTSISTARRLAEFLGDEMVKDAGLSFKFIISKKPEGQQVTDRAIPVAIFQAEESVKRFYLSKWLKSKDLQDFDIRNILDWDYYINRFSSNIQKIITIPAALQEVPNPVPRVAHPDWLHKILMEKDNRFKQQRITDIF-----QTITPSQAAADKMK----DIENCAPISKKKPTGVTSLKRAR----NKDTVDVYGVQLDMDNLPNHWRDILGDPVPKGNSKSQFIVWLEFHXXXXXXXXXXXDQSELS---KENINPAT-VKRIKTVKKGIQSGISSFFTRSKQSILEDTWQIIQITDTNVSGIYRVWVLIGQEIHNMKLTVPRTFYVNTRIPKAPGENMYFKQVHKLLPRSRIVYHLYEYNLDETIFIKHRSDILSEFIRNEVEGIYELEVPLLLRVYAKLGCMCSIDRNHFTDQQLSNNPSSFLLNELKFRSTAQHPYLSPNSIKTTFLFQQKSNRNEIIGWFDPCNNRAHLCLVEQSKPNPDKFQANVVQSWFSREREAFLSLKENESLISVVPEHVQFEVSSHKFEISAFKAINKLLVAHRNEVTTPTFIATKSKMTINELYSNLPALQEYPLVPITINETDVSFNVLDWQRIAIKSALQNFVKYEKLLAEMLERARYLHIPVGNMSKFTNDYRGISDSYDLFYGRFLMKNNFIWWCNDKSEPDLGKKENQDRRMMLVDNDVLNGMIYRNKPGCYPTTCVQLEMTYFPINTIIAMHKVMEIDGTNERLFESMIVPAKTIDQAMIQSKCNAAKRNLNLTSNTMYDDVTAAGPAFKILRNVILQWLDDVRNYKNPVADEHLMGFYKWMKNSRSLFYDPALFKSLQKLMRMVFFKLIEQLNNLGVEVIYGTLNKIVLCTKRTDLMDALVHVEYATKTVRNQDIFSQLDFQYVSGWDYLIWQDVSNYSGIKSDLESVTKEEHNSMVLEELSFVNMTNPSLSMGLSQSQNEDSFLTTEIADSSQIEMNWHLSRYLSPMSGVQLRLIEILQYFMLTNWKIVKDEYK--------LNRLAAKNDVAEEAVNTGTILGSDASLYPSSVQRMEDFLQNEMGYKLYLLVSQL-KDVPRMHNAVPLTTXXXXXXXXXXXSNKTPPLLPLKNKVSLHPIVDLIKTTCHILALDTSARYYVNDWKRNMFKLINFDAYSDQAKWRSPYSSDQSMGDAFRSDLIITVPEVICDNCNVTRDLDLCRD---LYQVRIKNSWWFVCPTCDFPYDRNVIQETLIDQVRCICESNVMQDLKCTKCTNGILETSLAGTENCVKCGNAIQVTQNAASLKEKIKIYADIGKHYDLPYLHMMTSWMLQGEDLS 7019
            +++ R +  D++DL +GF+       RTGWLINM  T+ +D++KRLVSA+ YYF+++DGS+FK  L + PYFYI  + GC+ E+ ++L KK+   +  +E + KEDLDL NHL+GLK+ ++KL FHT++DLV+VRKEI P +K+N++   + ++Y+ ML+   QG      E    K   D +DN +D+REYDVPYH+R+SID  I +  WY+V    N        IT R D+V+ P+P+VLA+DIETTKLPLKFPDA  DQIMMISYMIDG GYLI NREI+++DIEDFEFTP+PE+ GPF VFNEP+E   I+R+F+HI+E KP I VTYNGDFFDWPFVE RA  HGL M   IGF KD+Q EYK+   IHMDC +WV+RDSYLP+G+  LKA  KAKL Y+PVE+DPE+MC++A E P+TLA YSVSDAVATYYLYMKYVHPFIFALCTIIPM+PDEVLRKGSGTLCE LLMV+AF++NIIFPNKQE + N LT+DGH++++ETYVGGHVEA+ESGVFRSDIP +F++ P    FL + +++T+ H +E EEKV V+   NF EV   I  KL  L++   R ECP+IYHLDV AMYPNIIL+NRLQPSA+V+E TC ACDFN P A C+R M W+WRGE MPA++SEY+ IQ+QLE EKFPP  P  P R+F+EL + EQA  EK RL  +CR AY + H T+ EER   +CQREN+FYVDTVRAFRDRRY++K L KV KK+L   +  E GDASE+KR   M +LYDSLQLAHKCILNSFYGYVMRKGARWYSMEMAGIVC TGA II  ARE+IEQIGRPLELDTDGIWC+LP SFP+ F  +T N KK  ++ SYPGAMLN+MV++ FTN QY +L +P+  TY   SENSIFFEVDGPYLAMILPASKE  KKLKKRYAVFN D SLAELKGFEVKR GEL LIKIFQSSVFE+FLKGS++ EVY  VA VA+YWLD+LYS+A+ MPD ELFELISE R MS+KLE+YG+QKSTSISTA+RLAEFLGD+MVKDAGLS ++IIS+KPEG  VT+RAIP+AIFQAE +V++ +L KWLKS  LQDFDIR ILDWDYYI R  S IQKIITIPAALQ+V NPVPRV HPDWLHK L+EK++ +KQ++I+++F     + I  +QA+ + +     D+E+         T   + KR R     K++ D+         L   W+++LG P   G ++ +++VWL+FHKKKW++Q     Q  L+   K+ +  A  + R+  +++G  +G+ SF  R+ +SI++  WQIIQI++T  +G++R+W +IG ++H +KL++PR FYVN R+ KA     Y ++V++ LPRS IVY+LYEY++ E ++ +H ++I +E    ++EG+YE +VPLL R   +LGC+C +++   T         +F L  L+ RS AQ  YL P SI+  +L+        + G F P   RA + +++  + N    Q   + + +S E    L  K +  L+   P+H  FEV +     +  +AI + L+A++ E   PT IA +S   +  L S +P L+E+PLVPI + +  +S+ VLDWQR   +  +++++  +  L++  E +RY HIPVGN+ +  + +       DLF+ R L  +N + W +  S PDLG KE  D R+++  +D     +  N  GCY T CV+L++    +NTI+  H V +++G       SM +    I QA ++        N   ++   YD+       F+IL+++++ W+ ++  Y N  AD  +M FY+W+++  SL +DPAL ++L  +M+ +F +LI +   LG  V+Y   N+I+LCTK+  + DAL +VEY T ++ +++IF  L   +   W++L+W D SNY GIK  + S     H   V E+ S              + + E+    +E+ D   +E NW++ ++L   +  Q   + I+  +++  ++ +K+E +        + R  A     E    TG++        P  +   +D++ NE+    + +  ++ K V    N                E ++  P+LP  + +  +P ++ IK  C +L+LDT+    VN   R++ +L++   +S++A++R P  S               +PEVIC +CN  RDLDLC+D        I   W  +C  C  PYD + I+  L++ ++    +  +QDL C KC  G+ ET +        C     +T       E+I+I+ +I K+Y + YL     W+LQ   +S
Sbjct:   33 KRLERSQWTDKMDLRFGFERLKEPGERTGWLINMHPTEILDEDKRLVSAVDYYFIQDDGSRFKVALPYMPYFYIAARKGCDREVSSFLSKKFQGKIAKLENVPKEDLDLPNHLVGLKRSYIKLSFHTVEDLVKVRKEISPAVKKNREQDHASDEYTTMLSSILQGGSVITDEDETSKKIADQLDNIVDMREYDVPYHIRLSIDLRIHVAHWYNVRFRGN---AFPVEITRRDDLVERPDPVVLAFDIETTKLPLKFPDAETDQIMMISYMIDGQGYLITNREIVSEDIEDFEFTPKPEYEGPFCVFNEPDEVHLIQRWFEHIQETKPTIMVTYNGDFFDWPFVEARAAIHGLSMYQEIGFQKDSQGEYKAPQCIHMDCLRWVKRDSYLPVGSHNLKAAAKAKLGYDPVELDPEDMCRMATEQPQTLATYSVSDAVATYYLYMKYVHPFIFALCTIIPMEPDEVLRKGSGTLCEALLMVQAFHANIIFPNKQEQEFNKLTDDGHMLDAETYVGGHVEALESGVFRSDIPCRFRMNPAAFDFLLQRVEKTMRHAIEEEEKVPVEQATNFQEVCEQIKTKLTSLKDVPNRIECPLIYHLDVGAMYPNIILTNRLQPSAIVDEATCAACDFNKPGASCQRKMAWQWRGEFMPASRSEYHRIQHQLESEKFPPLFPEGPARAFHELSREEQAKYEKRRLADYCRKAYKKIHVTKVEERLTTICQRENSFYVDTVRAFRDRRYEFKGLHKVWKKKLSAAV--EVGDASEVKRCKNMEILYDSLQLAHKCILNSFYGYVMRKGARWYSMEMAGIVCFTGANIITQARELIEQIGRPLELDTDGIWCVLPNSFPENFVIKTTNAKKPKLTISYPGAMLNIMVKEGFTNHQYQELTEPSSLTYVTHSENSIFFEVDGPYLAMILPASKEEGKKLKKRYAVFNEDGSLAELKGFEVKRRGELQLIKIFQSSVFEAFLKGSTLEEVYGSVAKVADYWLDVLYSKAANMPDSELFELISENRSMSRKLEDYGEQKSTSISTAKRLAEFLGDQMVKDAGLSCRYIISRKPEGSPVTERAIPLAIFQAEPTVRKHFLRKWLKSSSLQDFDIRTILDWDYYIERLGSAIQKIITIPAALQQVKNPVPRVKHPDWLHKKLLEKNDIYKQKKISELFVLEGKRQIVMAQASENSLSLCTPDMEDIGLTKPHHSTVPVATKRKRVWETQKESQDI--------ALTVPWQEVLGQPPSLGTTQEEWLVWLQFHKKKWQLQA----QQRLALRKKQRLESAEDMPRLGPIREGPSTGLGSFLRRTARSIMDLPWQIIQISETRQAGLFRLWAIIGNDLHCIKLSIPRVFYVNQRVAKAEDGPAY-RKVNRALPRSNIVYNLYEYSVPEDMYQEHINEINTELSVPDIEGVYETQVPLLFRALVQLGCVCVVNK-QLTRHLSGWEAETFALEHLEMRSLAQFSYLEPGSIRHIYLYHHTQGHKALFGVFIPSQRRASVFVLDTVRSN----QMPGLSALYSSEHSLLLD-KVDPKLLP-PPKHT-FEVRAETNLKTICRAIQRFLLAYKEERRGPTLIAVQSSWELCRLTSEIPVLEEFPLVPIRVAD-KISYAVLDWQRHGARRMIRHYLNLDLCLSQAFEMSRYFHIPVGNLPEDISTF-----GSDLFFARHLQHHNHLLWLSPTSRPDLGGKEADDNRLVMEFDD--RATVEINSSGCYSTVCVELDIQNLAVNTILQSHHVNDMEGAG-----SMGISFDVIQQASLEDMVTG---NQAASALANYDETALCSSTFRILKSMVVGWVKEITQYHNIYADNQVMHFYRWLQSPCSLLHDPALHRTLHNMMKKLFLQLIAEFKRLGSSVVYANFNRIILCTKKRRIEDALAYVEYITNSIHSKEIFHSLTISFSRCWEFLLWMDPSNYGGIKGKVPSSI---HCGQVKEQDSQAREETDEEEEDKEKDEEEEGMGESEVED--LLENNWNILQFLPQAASCQSYFLMIVSAYIVAVYQSMKEELRHSAPGSTPVKRKGASQFSQESEGATGSL--------PGMITFSQDYVANELTQSFFTITQKIQKKVTGSRNTT--------------EPSEMFPVLPGSHLLLNNPALEFIKYVCKVLSLDTNITNQVNKLNRDLLRLVDVGEFSEEAQFRDPCHS-------------YVLPEVICHSCNFCRDLDLCKDSSFSQDGAILPQW--LCSNCQAPYDSSAIESALVEALQRKLMAFTLQDLVCLKC-RGMKETHMPVY---CSCAGDFTLTIRTEVFMEQIRIFQNIAKYYSMSYLQETIEWLLQTSPVS 2281
[Close]
BLAST of DNA polymerase epsilon catalytic subunit vs. Ensembl Mouse
Match: Pole (polymerase (DNA directed), epsilon [Source:MGI Symbol;Acc:MGI:1196391])

HSP 1 Score: 147.902 bits (372), Expect = 1.058e-39
Identity = 74/160 (46.25%), Postives = 117/160 (73.12%), Query Frame = 3 
Query:  102 EKILRLKKNDQIDLVYGFDLHSAIKIRTGWLINMKTTDAIDDNKRLVSAMSYYFLEEDGSKFKSTLIFQPYFYIVTKLGCESEIQTYLMKKYSACLHNIEIIEKEDLDLDNHXXXXXXXXXXXXXHTIDDLVRVRKEIMPKIKQNQKNQESDNDYSKMLT 581
            +++ R +  D++DL +GF+       RTGWLINM  T+ +D++KRLVSA+ YYF+++DGS+FK  L + PYFYI  + GC+ E+ ++L KK+   +  +E + KEDLDL NHL+GLK+ ++KL FHT++DLV+VRKEI P +K+N++   + ++Y+ ML+
Sbjct:   33 KRLERSQWTDKMDLRFGFERLKEPGERTGWLINMHPTEILDEDKRLVSAVDYYFIQDDGSRFKVALPYMPYFYIAARKGCDREVSSFLSKKFQGKIAKLENVPKEDLDLPNHLVGLKRSYIKLSFHTVEDLVKVRKEISPAVKKNREQDHASDEYTTMLS 192
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BLAST of DNA polymerase epsilon catalytic subunit vs. Ensembl Mouse
Match: Pole (polymerase (DNA directed), epsilon [Source:MGI Symbol;Acc:MGI:1196391])

HSP 1 Score: 140.198 bits (352), Expect = 1.047e-34
Identity = 108/435 (24.83%), Postives = 196/435 (45.06%), Query Frame = 3 
Query: 5751 VRNQDIFSQLDFQYVSGWDYLIWQDVSNYSGIKSDLESVTKEEHNSMVLEELSFVNMTNPSLSMGLSQSQNEDSFLTTEIADSSQIEMNWHLSRYLSPMSGVQLRLIEILQYFMLTNWKIVKDEYK--------LNRLAAKNDVAEEAVNTGTILGSDASLYPSSVQRMEDFLQNEMGYKLYLLVSQL-KDVPRMHNAVPLTTXXXXXXXXXXXSNKTPPLLPLKNKVSLHPIVDLIKTTCHILALDTSARYYVNDWKRNMFKLINFDAYSDQAKWRSPYSSDQSMGDAFRSDLIITVPEVICDNCNVTRDLDLCRDLYQVR---IKNSWWFVCPTCDFPYDRNVIQETLIDQVRCICESNVMQDLKCTKCTNGILETSLAGTENCVKCGNAIQVTQNAASLKEKIKIYADIGKHYDLPYLHMMTSWMLQGEDLS 7019
            + +++IF  L   +   W++L+W D SNY GIK  + S     H   V E+ S              + + E+    +E+ D   +E NW++ ++L   +  Q   + I+  +++  ++ +K+E +        + R  A     E    TG++        P  +   +D++ NE+    + +  ++ K V    N                E ++  P+LP  + +  +P ++ IK  C +L+LDT+    VN   R++ +L++   +S++A++R P  S               +PEVIC +CN  RDLDLC+D    +   I   W  +C  C  PYD + I+  L++ ++    +  +QDL C KC  G+ ET +        C     +T       E+I+I+ +I K+Y + YL     W+LQ   +S
Sbjct:   17 IHSKEIFHSLTISFSRCWEFLLWMDPSNYGGIKGKVPSSI---HCGQVKEQDSQAREETDEEEEDKEKDEEEEGMGESEVED--LLENNWNILQFLPQAASCQSYFLMIVSAYIVAVYQSMKEELRHSAPGSTPVKRKGASQFSQESEGATGSL--------PGMITFSQDYVANELTQSFFTITQKIQKKVTGSRNTT--------------EPSEMFPVLPGSHLLLNNPALEFIKYVCKVLSLDTNITNQVNKLNRDLLRLVDVGEFSEEAQFRDPCHS-------------YVLPEVICHSCNFCRDLDLCKDSSFSQDGAILPQW--LCSNCQAPYDSSAIESALVEALQRKLMAFTLQDLVCLKC-RGMKETHMPVY---CSCAGDFTLTIRTEVFMEQIRIFQNIAKYYSMSYLQETIEWLLQTSPVS 405
[Close]
BLAST of DNA polymerase epsilon catalytic subunit vs. UniProt/SwissProt
Match: sp|Q07864|DPOE1_HUMAN (DNA polymerase epsilon catalytic subunit A OS=Homo sapiens OX=9606 GN=POLE PE=1 SV=5)

HSP 1 Score: 2138.61 bits (5540), Expect = 0.000e+0
Identity = 1092/2325 (46.97%), Postives = 1522/2325 (65.46%), Query Frame = 3 
Query:  102 EKILRLKKNDQIDLVYGFDLHSAIKIRTGWLINMKTTDAIDDNKRLVSAMSYYFLEEDGSKFKSTLIFQPYFYIVTKLGCESEIQTYLMKKYSACLHNIEIIEKEDLDLDNHXXXXXXXXXXXXXHTIDDLVRVRKEIMPKIKQNQKNQESDNDYSKMLTEHFQ--GEKKYEYNARKSALDIMDNAIDIREYDVPYHVRVSIDTAIFIGKWYDVHGSMNIKGPNSTHITPRSDIVDHPEPIVLAYDIETTKLPLKFPDATFDQIMMISYMIDGMGYLICNREIIADDIEDFEFTPRPEFPGPFSVFNEPNEKRTIERFFDHIREVKPNIFVTYNGDFFDWPFVETRAVKHGLDMLDYIGFSKDNQNEYKSRSAIHMDCFKWVQRDSYLPIGAQGLKAVCKAKLRYNPVEVDPEEMCKVAREDPRTLANYSVSDAVATYYLYMKYVHPFIFALCTIIPMDPDEVLRKGSGTLCECLLMVEAFNSNIIFPNKQESKLNPLTNDGHVIESETYVGGHVEAIESGVFRSDIPTKFKIVPEMCKFLRKNLKETLVHVLEVEEKVTVDSVLNFDEVYNAIDEKLEDLEETNIRFECPVIYHLDVAAMYPNIILSNRLQPSALVNEKTCGACDFNVPNAKCKRPMTWKWRGEIMPATKSEYYLIQNQLEKEKFPPKKPSLPMRSFYELDKLEQATVEKERLGKFCRNAYNRKHNTRFEERTAVVCQRENAFYVDTVRAFRDRRYQYKDLTKVSKKRLDELISSENGDASEIKRANGMLVLYDSLQLAHKCILNSFYGYVMRKGARWYSMEMAGIVCSTGAAIIKYAREMIEQIGRPLELDTDGIWCILPASFPQGFEFQTNNPKKRNISFSYPGAMLNLMVQQYFTNDQYHDLVDPAKHTYRIRSENSIFFEVDGPYLAMILPASKEMNKKLKKRYAVFNRDRSLAELKGFEVKRNGELNLIKIFQSSVFESFLKGSSISEVYQHVAIVANYWLDLLYSRASTMPDEELFELISEKRCMSKKLEEYGKQKSTSISTARRLAEFLGDEMVKDAGLSFKFIISKKPEGQQVTDRAIPVAIFQAEESVKRFYLSKWLKSKDLQDFDIRNILDWDYYINRFSSNIQKIITIPAALQEVPNPVPRVAHPDWLHKILMEKDNRFKQQRITDIF-----QTITPSQAAADKMK----DIENCAPISKKKPTGVTSLKRARNKDTVDVYGVQLDMDNLPN-HWRDILGDPVPKGNSKSQFIVWLEFHXXXXXXXXXXXDQSELSKENINPATVKRIKTVKKGIQSGISSFFTRSKQSILEDTWQIIQITDTNVSGIYRVWVLIGQEIHNMKLTVPRTFYVNTRIPKAPGENMYFKQVHKLLPRSRIVYHLYEYNLDETIFIKHRSDILSEFIRNEVEGIYELEVPLLLRVYAKLGCMCSIDRNHFTDQQLSN-NPSSFLLNELKFRSTAQHPYLSPNSIKTTFLFQQKSNRNEIIGWFDPCNNRAHLCLVEQSKPNPDKFQANVVQSWFSREREAFLSLKENESLISVVPEHVQFEVSSHKFEISAFKAINKLLVAHRNEVTTPTFIATKSKMTINELYSNLPALQEYPLVPITINETDVSFNVLDWQRIAIKSALQNFVKYEKLLAEMLERARYLHIPVGNMSKFTNDYRGISDSYDLFYGRFLMKNNFIWWCNDKSEPDLGKKENQDRRMMLVDNDVLNGMIYRNKPGCYPTTCVQLEMTYFPINTIIAMHKVMEIDGTNERLFESMIVPAKTIDQAMIQSKCNAAKRNLNLTSNTMYDDVTAAGPAFKILRNVILQWLDDVRNYKNPVADEHLMGFYKWMKNSRSLFYDPALFKSLQKLMRMVFFKLIEQLNNLGVEVIYGTLNKIVLCTKRTDLMDALVHVEYATKTVRNQDIFSQLDFQYVSGWDYLIWQDVSNYSGIKSDLESVTKEEHNSMVLEELSFVNMTNPSLSMGLSQSQNEDSFLTTEIADSSQIEMNWHLSRYLSPMSGVQLRLIEILQYFMLTNWKIVKDEYKLN-------RLAAKNDVAEEAVNTGTILGSDASLYPSSVQRMEDFLQNEMGYKLYLLVSQL-KDVPRMHNAVPLTTXXXXXXXXXXXSNKTPPLLPLKNKVSLHPIVDLIKTTCHILALDTSARYYVNDWKRNMFKLINFDAYSDQAKWRSPYSSDQSMGDAFRSDLIITVPEVICDNCNVTRDLDLCRDLY---QVRIKNSWWFVCPTCDFPYDRNVIQETLIDQVRCICESNVMQDLKCTKCTNGILETSLAGTENCVKCGNAIQVTQNAASLKEKIKIYADIGKHYDLPYLHMMTSWMLQ 7004
            +++ R +  D++DL +GF+       +TGWLINM  T+ +D++KRL SA+ YYF+++DGS+FK  L ++PYFYI T+ GCE E+ ++L KK+   +  +E + KEDLDL NHL+GLK+ +++L FHT++DLV+VRKEI P +K+N++   + + Y+ +L+   Q  G    E    K   D +DN +D+REYDVPYH+R+SID  I +  WY+V    N        IT R D+V+ P+P+VLA+DIETTKLPLKFPDA  DQIMMISYMIDG GYLI NREI+++DIEDFEFTP+PE+ GPF VFNEP+E   I+R+F+H++E KP I VTYNGDFFDWPFVE RA  HGL M   IGF KD+Q EYK+   IHMDC +WV+RDSYLP+G+  LKA  KAKL Y+PVE+DPE+MC++A E P+TLA YSVSDAVATYYLYMKYVHPFIFALCTIIPM+PDEVLRKGSGTLCE LLMV+AF++NIIFPNKQE + N LT+DGHV++SETYVGGHVEA+ESGVFRSDIP +F++ P    FL + +++TL H LE EEKV V+ V NF+EV + I  KL  L++   R ECP+IYHLDV AMYPNIIL+NRLQPSA+V+E TC ACDFN P A C+R M W+WRGE MPA++SEY+ IQ+QLE EKFPP  P  P R+F+EL + EQA  EK RL  +CR AY + H T+ EER   +CQREN+FYVDTVRAFRDRRY++K L KV KK+L   +  E GDA+E+KR   M VLYDSLQLAHKCILNSFYGYVMRKGARWYSMEMAGIVC TGA II  ARE+IEQIGRPLELDTDGIWC+LP SFP+ F F+T N KK  ++ SYPGAMLN+MV++ FTNDQY +L +P+  TY  RSENSIFFEVDGPYLAMILPASKE  KKLKKRYAVFN D SLAELKGFEVKR GEL LIKIFQSSVFE+FLKGS++ EVY  VA VA+YWLD+LYS+A+ MPD ELFELISE R MS+KLE+YG+QKSTSISTA+RLAEFLGD+MVKDAGLS ++IIS+KPEG  VT+RAIP+AIFQAE +V++ +L KWLKS  LQDFDIR ILDWDYYI R  S IQKIITIPAALQ+V NPVPRV HPDWLHK L+EK++ +KQ++I+++F     + +T ++A+ D  +    D+E+   +    P    ++KR R    V     +   D  P   W++ILG P   G S+ +++VWL FHKKKW++Q   +      +   +   V R   ++ G  +G+ SF  R+ +SIL+  WQI+QI++T+ +G++R+W L+G ++H ++L++PR FYVN R+ KA  E   +++V+++LPRS +VY+LYEY++ E ++ +H ++I +E    ++EG+YE +VPLL R    LGC+C +++     + LS     +F L  L+ RS AQ  YL P SI+  +L+        + G F P   RA + +++  + N    Q   + + +S E    L     E L    P+H  FEV +     +  +AI + L+A++ E   PT IA +S   +  L S +P L+E+PLVPI + +  +++ VLDWQR   +  +++++  +  L++  E +RY HIP+GN+ +  + +       DLF+ R L ++N + W +  + PDLG KE  D  +++  +D     +  N  GCY T CV+L++    +NTI+  H V +++G +     SM +    I QA ++      +     ++   YD+       F+IL+++++ W+ ++  Y N  AD  +M FY+W+++  SL +DPAL ++L  +M+ +F +LI +   LG  VIY   N+I+LCTK+  + DA+ +VEY T ++ +++ F  L   +   W++L+W D SNY GIK     V+   H  +   + +              +   E+     E      +E NW++ ++L   +  Q   + I+  +++  +  +KD  + +       R    + +++EA       G+  +L P  +   +D++ NE+    + +  ++ K V    N+  L+                 P+LP  + +  +P ++ IK  C +L+LDT+    VN   R++ +L++   +S++A++R P  S               +PEVIC +CN  RDLDLC+D        +   W  +C  C  PYD + I+ TL++ ++    +  +QDL C KC  G+ ETS+        C     +T +     E+I I+ +I +HY + YL     W+LQ
Sbjct:   33 KRLERSQWTDKMDLRFGFERLKEPGEKTGWLINMHPTEILDEDKRLGSAVDYYFIQDDGSRFKVALPYKPYFYIATRKGCEREVSSFLSKKFQGKIAKVETVPKEDLDLPNHLVGLKRNYIRLSFHTVEDLVKVRKEISPAVKKNREQDHASDAYTALLSSVLQRGGVITDEEETSKKIADQLDNIVDMREYDVPYHIRLSIDLKIHVAHWYNVRYRGNA---FPVEITRRDDLVERPDPVVLAFDIETTKLPLKFPDAETDQIMMISYMIDGQGYLITNREIVSEDIEDFEFTPKPEYEGPFCVFNEPDEAHLIQRWFEHVQETKPTIMVTYNGDFFDWPFVEARAAVHGLSMQQEIGFQKDSQGEYKAPQCIHMDCLRWVKRDSYLPVGSHNLKAAAKAKLGYDPVELDPEDMCRMATEQPQTLATYSVSDAVATYYLYMKYVHPFIFALCTIIPMEPDEVLRKGSGTLCEALLMVQAFHANIIFPNKQEQEFNKLTDDGHVLDSETYVGGHVEALESGVFRSDIPCRFRMNPAAFDFLLQRVEKTLRHALEEEEKVPVEQVTNFEEVCDEIKSKLASLKDVPSRIECPLIYHLDVGAMYPNIILTNRLQPSAMVDEATCAACDFNKPGANCQRKMAWQWRGEFMPASRSEYHRIQHQLESEKFPPLFPEGPARAFHELSREEQAKYEKRRLADYCRKAYKKIHITKVEERLTTICQRENSFYVDTVRAFRDRRYEFKGLHKVWKKKLSAAV--EVGDAAEVKRCKNMEVLYDSLQLAHKCILNSFYGYVMRKGARWYSMEMAGIVCFTGANIITQARELIEQIGRPLELDTDGIWCVLPNSFPENFVFKTTNVKKPKVTISYPGAMLNIMVKEGFTNDQYQELAEPSSLTYVTRSENSIFFEVDGPYLAMILPASKEEGKKLKKRYAVFNEDGSLAELKGFEVKRRGELQLIKIFQSSVFEAFLKGSTLEEVYGSVAKVADYWLDVLYSKAANMPDSELFELISENRSMSRKLEDYGEQKSTSISTAKRLAEFLGDQMVKDAGLSCRYIISRKPEGSPVTERAIPLAIFQAEPTVRKHFLRKWLKSSSLQDFDIRAILDWDYYIERLGSAIQKIITIPAALQQVKNPVPRVKHPDWLHKKLLEKNDVYKQKKISELFTLEGRRQVTMAEASEDSPRPSAPDMEDFGLVKLPHPAAPVTVKRKR----VLWESQEESQDLTPTVPWQEILGQPPALGTSQEEWLVWLRFHKKKWQLQARQRLARRKRQRLESAEGVLRPGAIRDGPATGLGSFLRRTARSILDLPWQIVQISETSQAGLFRLWALVGSDLHCIRLSIPRVFYVNQRVAKAE-EGASYRKVNRVLPRSNMVYNLYEYSVPEDMYQEHINEINAELSAPDIEGVYETQVPLLFRALVHLGCVCVVNKQLV--RHLSGWEAETFALEHLEMRSLAQFSYLEPGSIRHIYLYHHAQAHKALFGIFIPSQRRASVFVLDTVRSN----QMPSLGALYSAEHGLLLEKVGPELLPP--PKHT-FEVRAETDLKTICRAIQRFLLAYKEERRGPTLIAVQSSWELKRLASEIPVLEEFPLVPICVADK-INYGVLDWQRHGARRMIRHYLNLDTCLSQAFEMSRYFHIPIGNLPEDISTF-----GSDLFFARHLQRHNHLLWLSPTARPDLGGKEADDNCLVMEFDD--QATVEINSSGCYSTVCVELDLQNLAVNTILQSHHVNDMEGAD-----SMGISFDVIQQASLEDMITGGQ---AASAPASYDETALCSNTFRILKSMVVGWVKEITQYHNIYADNQVMHFYRWLRSPSSLLHDPALHRTLHNMMKKLFLQLIAEFKRLGSSVIYANFNRIILCTKKRRVEDAIAYVEYITSSIHSKETFHSLTISFSRCWEFLLWMDPSNYGGIKG---KVSSRIHCGLQDSQKAGGAEDEQENEDDEEERDGEEEEEAEESNVEDLLENNWNILQFLPQAASCQNYFLMIVSAYIVAVYHCMKDGLRRSAPGSTPVRRRGASQLSQEAE------GAVGAL-PGMITFSQDYVANELTQSFFTITQKIQKKVTGSRNSTELSEMF--------------PVLPGSHLLLNNPALEFIKYVCKVLSLDTNITNQVNKLNRDLLRLVDVGEFSEEAQFRDPCRS-------------YVLPEVICRSCNFCRDLDLCKDSSFSEDGAVLPQW--LCSNCQAPYDSSAIEMTLVEVLQKKLMAFTLQDLVCLKC-RGVKETSMPVY---CSCAGDFALTIHTQVFMEQIGIFRNIAQHYGMSYLLETLEWLLQ 2279
[Close]
BLAST of DNA polymerase epsilon catalytic subunit vs. UniProt/SwissProt
Match: sp|Q9WVF7|DPOE1_MOUSE (DNA polymerase epsilon catalytic subunit A OS=Mus musculus OX=10090 GN=Pole PE=1 SV=3)

HSP 1 Score: 2129.75 bits (5517), Expect = 0.000e+0
Identity = 1099/2337 (47.03%), Postives = 1523/2337 (65.17%), Query Frame = 3 
Query:  102 EKILRLKKNDQIDLVYGFDLHSAIKIRTGWLINMKTTDAIDDNKRLVSAMSYYFLEEDGSKFKSTLIFQPYFYIVTKLGCESEIQTYLMKKYSACLHNIEIIEKEDLDLDNHXXXXXXXXXXXXXHTIDDLVRVRKEIMPKIKQNQKNQESDNDYSKMLTEHFQGEKKY--EYNARKSALDIMDNAIDIREYDVPYHVRVSIDTAIFIGKWYDVHGSMNIKGPNSTHITPRSDIVDHPEPIVLAYDIETTKLPLKFPDATFDQIMMISYMIDGMGYLICNREIIADDIEDFEFTPRPEFPGPFSVFNEPNEKRTIERFFDHIREVKPNIFVTYNGDFFDWPFVETRAVKHGLDMLDYIGFSKDNQNEYKSRSAIHMDCFKWVQRDSYLPIGAQGLKAVCKAKLRYNPVEVDPEEMCKVAREDPRTLANYSVSDAVATYYLYMKYVHPFIFALCTIIPMDPDEVLRKGSGTLCECLLMVEAFNSNIIFPNKQESKLNPLTNDGHVIESETYVGGHVEAIESGVFRSDIPTKFKIVPEMCKFLRKNLKETLVHVLEVEEKVTVDSVLNFDEVYNAIDEKLEDLEETNIRFECPVIYHLDVAAMYPNIILSNRLQPSALVNEKTCGACDFNVPNAKCKRPMTWKWRGEIMPATKSEYYLIQNQLEKEKFPPKKPSLPMRSFYELDKLEQATVEKERLGKFCRNAYNRKHNTRFEERTAVVCQRENAFYVDTVRAFRDRRYQYKDLTKVSKKRLDELISSENGDASEIKRANGMLVLYDSLQLAHKCILNSFYGYVMRKGARWYSMEMAGIVCSTGAAIIKYAREMIEQIGRPLELDTDGIWCILPASFPQGFEFQTNNPKKRNISFSYPGAMLNLMVQQYFTNDQYHDLVDPAKHTYRIRSENSIFFEVDGPYLAMILPASKEMNKKLKKRYAVFNRDRSLAELKGFEVKRNGELNLIKIFQSSVFESFLKGSSISEVYQHVAIVANYWLDLLYSRASTMPDEELFELISEKRCMSKKLEEYGKQKSTSISTARRLAEFLGDEMVKDAGLSFKFIISKKPEGQQVTDRAIPVAIFQAEESVKRFYLSKWLKSKDLQDFDIRNILDWDYYINRFSSNIQKIITIPAALQEVPNPVPRVAHPDWLHKILMEKDNRFKQQRITDIF-----QTITPSQAAADKMK----DIENCAPISKKKPTGVTSLKRAR----NKDTVDVYGVQLDMDNLPNHWRDILGDPVPKGNSKSQFIVWLEFHXXXXXXXXXXXDQSELS---KENINPAT-VKRIKTVKKGIQSGISSFFTRSKQSILEDTWQIIQITDTNVSGIYRVWVLIGQEIHNMKLTVPRTFYVNTRIPKAPGENMYFKQVHKLLPRSRIVYHLYEYNLDETIFIKHRSDILSEFIRNEVEGIYELEVPLLLRVYAKLGCMCSIDRNHFTDQQLSNNPSSFLLNELKFRSTAQHPYLSPNSIKTTFLFQQKSNRNEIIGWFDPCNNRAHLCLVEQSKPNPDKFQANVVQSWFSREREAFLSLKENESLISVVPEHVQFEVSSHKFEISAFKAINKLLVAHRNEVTTPTFIATKSKMTINELYSNLPALQEYPLVPITINETDVSFNVLDWQRIAIKSALQNFVKYEKLLAEMLERARYLHIPVGNMSKFTNDYRGISDSYDLFYGRFLMKNNFIWWCNDKSEPDLGKKENQDRRMMLVDNDVLNGMIYRNKPGCYPTTCVQLEMTYFPINTIIAMHKVMEIDGTNERLFESMIVPAKTIDQAMIQSKCNAAKRNLNLTSNTMYDDVTAAGPAFKILRNVILQWLDDVRNYKNPVADEHLMGFYKWMKNSRSLFYDPALFKSLQKLMRMVFFKLIEQLNNLGVEVIYGTLNKIVLCTKRTDLMDALVHVEYATKTVRNQDIFSQLDFQYVSGWDYLIWQDVSNYSGIKSDLESVTKEEHNSMVLEELSFVNMTNPSLSMGLSQSQNEDSFLTTEIADSSQIEMNWHLSRYLSPMSGVQLRLIEILQYFMLTNWKIVKDEYK--------LNRLAAKNDVAEEAVNTGTILGSDASLYPSSVQRMEDFLQNEMGYKLYLLVSQL-KDVPRMHNAVPLTTXXXXXXXXXXXSNKTPPLLPLKNKVSLHPIVDLIKTTCHILALDTSARYYVNDWKRNMFKLINFDAYSDQAKWRSPYSSDQSMGDAFRSDLIITVPEVICDNCNVTRDLDLCRD---LYQVRIKNSWWFVCPTCDFPYDRNVIQETLIDQVRCICESNVMQDLKCTKCTNGILETSLAGTENCVKCGNAIQVTQNAASLKEKIKIYADIGKHYDLPYLHMMTSWMLQGEDLS 7019
            +++ R +  D++DL +GF+       RTGWLINM  T+ +D++KRLVSA+ YYF+++DGS+FK  L + PYFYI  + GC+ E+ ++L KK+   +  +E + KEDLDL NHL+GLK+ ++KL FHT++DLV+VRKEI P +K+N++   + ++Y+ ML+   QG      E    K   D +DN +D+REYDVPYH+R+SID  I +  WY+V    N        IT R D+V+ P+P+VLA+DIETTKLPLKFPDA  DQIMMISYMIDG GYLI NREI+++DIEDFEFTP+PE+ GPF VFNEP+E   I+R+F+HI+E KP I VTYNGDFFDWPFVE RA  HGL M   IGF KD+Q EYK+   IHMDC +WV+RDSYLP+G+  LKA  KAKL Y+PVE+DPE+MC++A E P+TLA YSVSDAVATYYLYMKYVHPFIFALCTIIPM+PDEVLRKGSGTLCE LLMV+AF++NIIFPNKQE + N LT+DGH++++ETYVGGHVEA+ESGVFRSDIP +F++ P    FL + +++T+ H +E EEKV V+   NF EV   I  KL  L++   R ECP+IYHLDV AMYPNIIL+NRLQPSA+V+E TC ACDFN P A C+R M W+WRGE MPA++SEY+ IQ+QLE EKFPP  P  P R+F+EL + EQA  EK RL  +CR AY + H T+ EER   +CQREN+FYVDTVRAFRDRRY++K L KV KK+L   +  E GDASE+KR   M +LYDSLQLAHKCILNSFYGYVMRKGARWYSMEMAGIVC TGA II  ARE+IEQIGRPLELDTDGIWC+LP SFP+ F  +T N KK  ++ SYPGAMLN+MV++ FTN QY +L +P+  TY   SENSIFFEVDGPYLAMILPASKE  KKLKKRYAVFN D SLAELKGFEVKR GEL LIKIFQSSVFE+FLKGS++ EVY  VA VA+YWLD+LYS+A+ MPD ELFELISE R MS+KLE+YG+QKSTSISTA+RLAEFLGD+MVKDAGLS ++IIS+KPEG  VT+RAIP+AIFQAE +V++ +L KWLKS  LQDFDIR ILDWDYYI R  S IQKIITIPAALQ+V NPVPRV HPDWLHK L+EK++ +KQ++I+++F     + I  +QA+ + +     D+E+         T   + KR R     K++ D+         L   W+++LG P   G ++ +++VWL+FHKKKW++Q     Q  L+   K+ +  A  + R+  +++G  +G+ SF  R+ +SI++  WQIIQI++T  +G++R+W +IG ++H +KL++PR FYVN R+ KA     Y ++V++ LPRS IVY+LYEY++ E ++ +H ++I +E    ++EG+YE +VPLL R   +LGC+C +++   T         +F L  L+ RS AQ  YL P SI+  +L+        + G F P   RA + +++  + N    Q   + + +S E    L  K +  L+   P+H  FEV +     +  +AI + L+A++ E   PT IA +S   +  L S +P L+E+PLVPI + +  +S+ VLDWQR   +  +++++  +  L++  E +RY HIPVGN+ +  + +       DLF+ R L  +N + W +  S PDLG KE  D R+++  +D     +  N  GCY T CV+L++    +NTI+  H V +++G       SM +    I QA ++        N   ++   YD+       F+IL+++++ W+ ++  Y N  AD  +M FY+W+++  SL +DPAL ++L  +M+ +F +LI +   LG  V+Y   N+I+LCTK+  + DAL +VEY T ++ +++IF  L   +   W++L+W D SNY GIK  + S     H   V E+ S              + + E+    +E+ D   +E NW++ ++L   +  Q   + I+  +++  ++ +K+E +        + R  A     E    TG++        P  +   +D++ NE+    + +  ++ K V    N                E ++  P+LP  + +  +P ++ IK  C +L+LDT+    VN   R++ +L++   +S++A++R P  S               +PEVIC +CN  RDLDLC+D        I   W  +C  C  PYD + I+  L++ ++    +  +QDL C KC  G+ ET +        C     +T       E+I+I+ +I K+Y + YL     W+LQ   +S
Sbjct:   33 KRLERSQWTDKMDLRFGFERLKEPGERTGWLINMHPTEILDEDKRLVSAVDYYFIQDDGSRFKVALPYMPYFYIAARKGCDREVSSFLSKKFQGKIAKLENVPKEDLDLPNHLVGLKRSYIKLSFHTVEDLVKVRKEISPAVKKNREQDHASDEYTTMLSSILQGGSVITDEDETSKKIADQLDNIVDMREYDVPYHIRLSIDLRIHVAHWYNVRFRGN---AFPVEITRRDDLVERPDPVVLAFDIETTKLPLKFPDAETDQIMMISYMIDGQGYLITNREIVSEDIEDFEFTPKPEYEGPFCVFNEPDEVHLIQRWFEHIQETKPTIMVTYNGDFFDWPFVEARAAIHGLSMYQEIGFQKDSQGEYKAPQCIHMDCLRWVKRDSYLPVGSHNLKAAAKAKLGYDPVELDPEDMCRMATEQPQTLATYSVSDAVATYYLYMKYVHPFIFALCTIIPMEPDEVLRKGSGTLCEALLMVQAFHANIIFPNKQEQEFNKLTDDGHMLDAETYVGGHVEALESGVFRSDIPCRFRMNPAAFDFLLQRVEKTMRHAIEEEEKVPVEQATNFQEVCEQIKTKLTSLKDVPNRIECPLIYHLDVGAMYPNIILTNRLQPSAIVDEATCAACDFNKPGASCQRKMAWQWRGEFMPASRSEYHRIQHQLESEKFPPLFPEGPARAFHELSREEQAKYEKRRLADYCRKAYKKIHVTKVEERLTTICQRENSFYVDTVRAFRDRRYEFKGLHKVWKKKLSAAV--EVGDASEVKRCKNMEILYDSLQLAHKCILNSFYGYVMRKGARWYSMEMAGIVCFTGANIITQARELIEQIGRPLELDTDGIWCVLPNSFPENFVIKTTNAKKPKLTISYPGAMLNIMVKEGFTNHQYQELTEPSSLTYVTHSENSIFFEVDGPYLAMILPASKEEGKKLKKRYAVFNEDGSLAELKGFEVKRRGELQLIKIFQSSVFEAFLKGSTLEEVYGSVAKVADYWLDVLYSKAANMPDSELFELISENRSMSRKLEDYGEQKSTSISTAKRLAEFLGDQMVKDAGLSCRYIISRKPEGSPVTERAIPLAIFQAEPTVRKHFLRKWLKSSSLQDFDIRTILDWDYYIERLGSAIQKIITIPAALQQVKNPVPRVKHPDWLHKKLLEKNDIYKQKKISELFVLEGKRQIVMAQASENSLSLCTPDMEDIGLTKPHHSTVPVATKRKRVWETQKESQDI--------ALTVPWQEVLGQPPSLGTTQEEWLVWLQFHKKKWQLQA----QQRLALRKKQRLESAEDMPRLGPIREGPSTGLGSFLRRTARSIMDLPWQIIQISETRQAGLFRLWAIIGNDLHCIKLSIPRVFYVNQRVAKAEDGPAY-RKVNRALPRSNIVYNLYEYSVPEDMYQEHINEINTELSVPDIEGVYETQVPLLFRALVQLGCVCVVNK-QLTRHLSGWEAETFALEHLEMRSLAQFSYLEPGSIRHIYLYHHTQGHKALFGVFIPSQRRASVFVLDTVRSN----QMPGLSALYSSEHSLLLD-KVDPKLLP-PPKHT-FEVRAETNLKTICRAIQRFLLAYKEERRGPTLIAVQSSWELCRLTSEIPVLEEFPLVPIRVAD-KISYAVLDWQRHGARRMIRHYLNLDLCLSQAFEMSRYFHIPVGNLPEDISTF-----GSDLFFARHLQHHNHLLWLSPTSRPDLGGKEADDNRLVMEFDD--RATVEINSSGCYSTVCVELDIQNLAVNTILQSHHVNDMEGAG-----SMGISFDVIQQASLEDMVTG---NQAASALANYDETALCSSTFRILKSMVVGWVKEITQYHNIYADNQVMHFYRWLQSPCSLLHDPALHRTLHNMMKKLFLQLIAEFKRLGSSVVYANFNRIILCTKKRRIEDALAYVEYITNSIHSKEIFHSLTISFSRCWEFLLWMDPSNYGGIKGKVPSSI---HCGQVKEQDSQAREETDEEEEDKEKDEEEEGMGESEVED--LLENNWNILQFLPQAASCQSYFLMIVSAYIVAVYQSMKEELRHSAPGSTPVKRKGASQFSQESEGATGSL--------PGMITFSQDYVANELTQSFFTITQKIQKKVTGSRNTT--------------EPSEMFPVLPGSHLLLNNPALEFIKYVCKVLSLDTNITNQVNKLNRDLLRLVDVGEFSEEAQFRDPCHS-------------YVLPEVICHSCNFCRDLDLCKDSSFSQDGAILPQW--LCSNCQAPYDSSAIESALVEALQRKLMAFTLQDLVCLKC-RGMKETHMPVY---CSCAGDFTLTIRTEVFMEQIRIFQNIAKYYSMSYLQETIEWLLQTSPVS 2281
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BLAST of DNA polymerase epsilon catalytic subunit vs. UniProt/SwissProt
Match: sp|Q9VCN1|DPOE1_DROME (DNA polymerase epsilon catalytic subunit 1 OS=Drosophila melanogaster OX=7227 GN=DNApol-epsilon255 PE=1 SV=3)

HSP 1 Score: 1843.55 bits (4774), Expect = 0.000e+0
Identity = 941/2023 (46.52%), Postives = 1323/2023 (65.40%), Query Frame = 3 
Query:   96 NEEKILRLKKNDQIDLVYGFDLHSAIKIRTGWLINMKTTDAIDDNKRLVSAMSYYFLEEDGSKFKSTLIFQPYFYIVTKLGCESEIQTYLMKKYSACLHNIEIIEKEDLDLDNHXXXXXXXXXXXXXHTIDDLVRVRKEIMPKIKQNQKNQESDNDYSKMLTEHFQGEKKYEYNAR--KSALDIMDNAIDIREYDVPYHVRVSIDTAIFIGKWYDVHGSMNIKGPNSTHITPRSDIVDHPEPIVLAYDIETTKLPLKFPDATFDQIMMISYMIDGMGYLICNREIIADDIEDFEFTPRPEFPGPFSVFNEPNEKRTIERFFDHIREVKPNIFVTYNGDFFDWPFVETRAVKHGLDMLDYIGFSKDNQNEYKSRSAIHMDCFKWVQRDSYLPIGAQGLKAVCKAKLRYNPVEVDPEEMCKVAREDPRTLANYSVSDAVATYYLYMKYVHPFIFALCTIIPMDPDEVLRKGSGTLCECLLMVEAFNSNIIFPNKQESKLNPLTNDGHVIESETYVGGHVEAIESGVFRSDIPTKFKIVPEMCKFLRKNLKETLVHVLEVEEKVTVDSVLNFDEVYNAIDEKLEDLEETNIRFECPVIYHLDVAAMYPNIILSNRLQPSALVNEKTCGACDFNVPNAKCKRPMTWKWRGEIMPATKSEYYLIQNQLEKEKFPPKKPSLPMRSFYELDKLEQATVEKERLGKFCRNAYNRKHNTRFEERTAVVCQRENAFYVDTVRAFRDRRYQYKDLTKVSKKRLDELISSENGDASEIKRANGMLVLYDSLQLAHKCILNSFYGYVMRKGARWYSMEMAGIVCSTGAAIIKYAREMIEQIGRPLELDTDGIWCILPASFPQGFEFQTNNPKKRNISFSYPGAMLNLMVQQYFTNDQYHDLVDPAKHT---YRIRSENSIFFEVDGPYLAMILPASKEMNKKLKKRYAVFNRDRSLAELKGFEVKRNGELNLIKIFQSSVFESFLKGSSISEVYQHVAIVANYWLDLLYSRASTMPDEELFELISEKRCMSKKLEEYGKQKSTSISTARRLAEFLGDEMVKDAGLSFKFIISKKPEGQQVTDRAIPVAIFQAEESVKRFYLSKWLKSKDLQDFDIRNILDWDYYINRFSSNIQKIITIPAALQEVPNPVPRVAHPDWLHKILMEKDNRFKQQRITDIFQT---ITPSQAAADKMKDIENCAPISKKKPTGVTSLKRARNKDTVDVYGVQLDMDNLPNH--WRDILGDPVPKGNSKSQFIVWLEFHXXXXXXXXXXXDQSELSKENI---NPATVKRIKTVKKGIQSGISSFFTRSKQSILEDTWQIIQITDTNVSGIYRVWVLIGQEIHNMKLTVPRTFYVNTRIPKAPGENMYFKQVHKLLPRSRIVYHLYEYNLDETIFIKHRSDILSEFIRNEVEGIYELEVPLLLRVYAKLGCMCSIDRNHFT--DQQLSNNPSSFLLNELKFRSTAQHPYLSP--NSIKTTFLFQQK--SNRNEIIGWFDPCNNRAHLCLVEQSKPNPDKFQANVVQSWFSREREAFLSLKENESLISVVPEHVQFEVSSHKFEISAFKAINKLLVAHRNEVTTPTFIATKSKMTINELYSNLPALQEYPLVPITINETDVSFNVLDWQRIAIKSALQNFVKYEKLLAEMLERARYLHIPVGNMSKFTNDYRGISDSYDLFYGRFLMKNNFIWWCNDKSEPDLGKKENQDRRMMLVDNDVLNGMIYRNKPGCYPTTCVQLEMTYFPINTIIAMHKVMEIDGTNERLFESMIVPAKTIDQAMIQSKCNAAKRNLNLTSNTMYDDVTAAGPAFKILRNVILQWLDDVRNYKNPVADEHLMGFYKWMKNSRSLFYDPALFKSLQKLMRMVFFKLIEQLNNLGVEVIYGTLNKIVLCTKRTDLMDALVHVEYATKTVRNQDIFSQLDFQYVSGWDYLIWQDVSNYSGIKSDL-----ESVTKEEHNSMVLEELSFVNMTNPSLSMGLSQSQNEDSFLTTEIADSSQIEMNWHLSRYLSPMSGVQLRLIEILQYFM 6092
            NE    + ++ND+ID  YGFD     + RTG+LINM + + +D+++RL++A+  +F++ DGS+FK T+ +QPY  I  +     E+  +L +KYS  +  +E I KEDLDL NHL GL++ ++KL F     + +VR+E+M  +K+NQ+ Q+S+  Y +ML            +A   K   D MD  +DIRE+DVPYHVRVSID  IF G+WY++     ++ P    IT R DI+D PEP+VLA+DIETTKLPLKFPDA  DQ+MMISYMIDG GYLI NREII+ +++DFE+TP+PEF G F VFNE NE + ++RFFDHI EV+P+I VTYNGDFFDWPFVETRA  + LDM   IGFSK     Y SR AIHMDC  WV+RDSYLP+G+QGLKAV KAKLRY+PVE+DPE+MC++A E P+ LANYSVSDAVATYYLYMKYVHPFIFAL TIIPM+PDE+LRKGSGTLCE LLMVEA+++ I++PNK +S+LN L+N+GHV++SETYVGGHVEA+ESGVFR+DIP +F++ P M K L++ +   L H +EVEE + ++ VLN DEV   I + L+ L +   R E PVIYHLDV AMYPNIIL+NRLQPSA+V++  C ACDFN P  +CKR M W WRGE++PA+++E+  IQ QLE EKFPP  P  P R+F+EL K +QA  EK+RL  +CR AY +   T+ E RT+ +CQ+EN+FYVDTVRAFRDRRY+YK LTKV+K  ++  ++S  GDA+EIK A G  VLYDSLQLAHKCILNSFYGYVMR+GARW+SM MAGIVC TG+ II  ARE+IE++GRPLELDTDGIWCILP SFPQ F   T++ KK+ I+ SYP A+LN MV+ +FTNDQYH+L    ++    Y IR ENSIFFEVDGPYLAM+LPA+KE  KKLKKRYAVFN D +LAELKGFEVKR GEL LIK FQSSVFE+FL GS++ E Y  VA VA+YWLD+LYSR S +PD ELFELISE + MSKKLEEYG QKSTSISTA+RLAEFLG++MVKDAGL+ K+IISKKPEG  VT+RAIP+AIFQ+E SV+R +L +WLK   + D DIR++LDW+YYI R    IQKIITIPAALQ + NPVPRV HPDWLHK ++EK++  KQ+RI ++F +     P     DK+ D+E+ A     +      +   R +  ++ +    D +  P    WR  LG P P G ++   + W+ F KKKWK Q+  + ++  + +     +P  V+       G  + +  F  R+++++L+  WQI+Q+   +  G + VW LIG+E+H +KLTVPR FYVN R    P E   +++V+++LPRSR V++LY Y++ E +F  +   +L++    ++EGIYE ++ L  R    +GC+C + R       Q  + +  +F + +L+ R   Q  YL+   N ++  +L+Q    + + EI       + +A +  ++  + N    Q   ++  ++ ER A L     E    +  E   FEV         ++ I + L  ++ E   PT +  ++ ++  +L   +P L E+P   I I++     + LDWQR   ++ +++F+    +L  ML++ RY H+P+GNM   T     +    DLF+ R L ++NF+ W +  + PDLG +E  D R++    + ++  + +NK G YP  CV+L +    ++ ++   ++ E++G +          A T D  M Q         +   +   YD+      AF+++R+++  WL +V   +N  +D  ++ FY+W+++S +L YDPAL +SL  LMR +F ++I +   LG  +IY   N+I+L + +  + DAL +V+Y  +++RN+++F  +   +   W++++W D +N+SGI+  L     E+V+     +M+ +     +          ++   E +    +  D   +E+NW +  +L   +  + +   +L  FM
Sbjct:   29 NEAGYRQSRENDKIDSKYGFDRVKDSQERTGYLINMHSNEVLDEDRRLIAALDLFFIQMDGSRFKCTVAYQPYLLIRPEDNMHLEVARFLGRKYSGQISGLEHITKEDLDLPNHLSGLQQQYIKLSFLNQTAMTKVRRELMSAVKRNQERQKSNTYYMQMLATSLAQSSAGSEDATLGKRQQDYMDCIVDIREHDVPYHVRVSIDLRIFCGQWYNIRCRSGVELPT---ITCRPDILDRPEPVVLAFDIETTKLPLKFPDAQTDQVMMISYMIDGQGYLITNREIISSNVDDFEYTPKPEFEGNFIVFNEENEMQLLQRFFDHIMEVRPHIIVTYNGDFFDWPFVETRAAVYDLDMKQEIGFSKLRDGNYLSRPAIHMDCLCWVKRDSYLPVGSQGLKAVAKAKLRYDPVELDPEDMCRMAVEQPQVLANYSVSDAVATYYLYMKYVHPFIFALNTIIPMEPDEILRKGSGTLCETLLMVEAYHAQIVYPNKHQSELNKLSNEGHVLDSETYVGGHVEALESGVFRADIPCRFRLDPAMVKQLQEQVDAVLRHAIEVEEGIPLEKVLNLDEVRQEIVQGLQGLHDIPNRLEQPVIYHLDVGAMYPNIILTNRLQPSAMVSDLDCAACDFNKPGVRCKRSMDWLWRGEMLPASRNEFQRIQQQLETEKFPPLFPGGPQRAFHELSKEDQAAYEKKRLTDYCRKAYKKTKLTKLETRTSTICQKENSFYVDTVRAFRDRRYEYKGLTKVAKASVNAAVAS--GDAAEIKAAKGREVLYDSLQLAHKCILNSFYGYVMRRGARWHSMPMAGIVCLTGSNIITKAREIIERVGRPLELDTDGIWCILPGSFPQEFTIHTSHEKKKKINISYPNAVLNTMVKDHFTNDQYHELRKDKENNLPKYDIRDENSIFFEVDGPYLAMVLPAAKEEGKKLKKRYAVFNFDGTLAELKGFEVKRRGELQLIKNFQSSVFEAFLAGSTLEECYASVAKVADYWLDVLYSRGSNLPDSELFELISENKSMSKKLEEYGAQKSTSISTAKRLAEFLGEQMVKDAGLACKYIISKKPEGAPVTERAIPLAIFQSEPSVRRHHLRRWLKDNTMGDADIRDVLDWNYYIERLGGTIQKIITIPAALQGLANPVPRVQHPDWLHKKMLEKNDVLKQRRINEMFTSRPKPKPLATEEDKLADMEDLAGKDGGEGAAGCPIVTKRKRIQLEEHD---DEEAQPQATTWRQALGAPPPIGETRKTIVEWVRFQKKKWKWQQDQRQRNRQASKRTRGEDPPVVR-----ATGSTATLGGFLRRAQRTLLDQPWQIVQLVPVDDLGHFTVWALIGEELHKIKLTVPRIFYVNQRSAAPPEEGQLWRKVNRVLPRSRPVFNLYRYSVPEQLFRDNSLGMLADLATPDIEGIYETQMTLEFRALMDMGCICGVQREEARRLAQLATKDLETFSIEQLEQRPQTQVKYLASANNRLRKIYLYQHNTPTAKKEIWSLILMPSKKAFVFALDTVRAN----QMPNMRQLYTAERLALLKNLTAEEQDKIPVEDYTFEVLIEVDVKQIYRHIQRALTTYKQEHQGPTILCLQTALSARKLSLAMPILLEFPQAEIHISDDASLLSGLDWQRQGSRAVIRHFLNLNNVLDLMLDQCRYFHVPIGNMPPDT-----VLFGADLFFARLLQRHNFVLWWSASTRPDLGGREADDSRLLAEFEESIS--VVQNKAGFYPDVCVELALDSLAVSALLQSTRIQEMEGASS---------AITFD-VMPQVSLEEMIGTVPAATLPSYDETALCSAAFRVMRSMVNGWLREVSINRNIFSDFQIVHFYRWVRSSNALLYDPALRRSLNNLMRKMFLRIIAEFKRLGATIIYADFNRIILSSGKKTVSDALGYVDYIVQSLRNKEMFHSIQLSFEQCWNFMLWMDQANFSGIRGKLPKGIDETVSSIVSTTMIRDSERNQDDDEDEEEDSENRDPVESNEAEQDQEDELSLELNWTIGEHLPDENECREKFESLLTLFM 2017

HSP 2 Score: 88.5817 bits (218), Expect = 7.789e-16
Identity = 50/159 (31.45%), Postives = 81/159 (50.94%), Query Frame = 3 
Query: 6417 PIVDLIKTTCHILALDTSARYYVNDWKRNMFKLINFDAYSDQAKWRSPYSSDQSMGDAFRSDLIITVPEVICDNCNVTRDLDLCRDLYQVRIKNSWWFVCPTCDFPYDRNVIQETLIDQVRCICESNVMQDLKCTKCTNGILETSLAGTENCVKCGNAI 6893
            P ++LI+T    L++D +    +N+ +RNM +L+    +SD A+W  P  S               + EVIC  CN  RDLDLC+D ++        ++C  C   YD   I+  ++D ++    S V+QDL+C++C+  I   +LA  E C   GN +
Sbjct: 2055 PGLELIRTLIKALSVDKTLAEQINELRRNMLRLVGIGEFSDLAEWEDPCDSH-------------IINEVICKACNHCRDLDLCKDKHRAMKDGVPVWLCAQCYVAYDNEEIEMRMLDALQRKMMSYVLQDLRCSRCSE-IKRENLA--EFCTCAGNFV 2197
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BLAST of DNA polymerase epsilon catalytic subunit vs. UniProt/SwissProt
Match: sp|Q4PFV5|DPOE_USTMA (DNA polymerase epsilon catalytic subunit A OS=Ustilago maydis (strain 521 / FGSC 9021) OX=237631 GN=POL2 PE=3 SV=1)

HSP 1 Score: 1568.52 bits (4060), Expect = 0.000e+0
Identity = 915/2403 (38.08%), Postives = 1349/2403 (56.14%), Query Frame = 3 
Query:   33 KNNQFKNPTEKE-----NDVFEAIERN---EEKILRLKKNDQIDLVYGFDLHSAIKIRTGWLINMKTTDAID-DNKRLVSAMSYYFLEEDGSKFKSTLIFQPYFYIVTKLGCESEIQTYLMKKYSACLHNIEIIEKEDLDLDNHXXXXXXXXXXXXXHTIDDLVRVRKEIMPKIKQNQKNQESDNDYSKMLT--------------------------EHFQGEKKYEYNARKSALDIMDNAIDIREYDVPYHVRVSIDTAIFIGKWYDVHGSMNIKGPNSTHITPRSDIVDHPEPIVLAYDIETTKLPLKFPDATFDQIMMISYMIDGMGYLICNREIIADDIEDFEFTPRPEFPGPFSVFNEPNEKRTIERFFDHIREVKPNIFVTYNGDFFDWPFVETRAVKHGLDMLDYIGFSKDNQNEYKSRSAIHMDCFKWVQRDSYLPIGAQGLKAVCKAKLRYNPVEVDPEEMCKVAREDPRTLANYSVSDAVATYYLYMKYVHPFIFALCTIIPMDPDEVLRKGSGTLCECLLMVEAFNSNIIFPNKQESKLNPLTN--DGHVIESETYVGGHVEAIESGVFRSDIPTKFKIVPEMCKFLRKNLKETLVHVLEVEEKVTVDSVLNFDEVYNAIDEKLEDLEETNIRFECPVIYHLDVAAMYPNIILSNRLQPSALVNEKTCGACDFNVPNAKCKRPMTWKWRGEIMPATKSEYYLIQNQLEKEKFPPKKPSLPMRSFYELDKLEQATVEKERLGKFCRNAYNRKHNTRFEERTAVVCQRENAFYVDTVRAFRDRRYQYKDLTKVSKKRLDELISSENGDASEIKRANGMLVLYDSLQLAHKCILNSFYGYVMRKGARWYSMEMAGIVCSTGAAIIKYAREMIEQIGRPLELDTDGIWCILPASFPQGFEFQTNNPKKRNISFSYPGAMLNLMVQQYFTNDQYHDLVDPAKHTYRIRSENSIFFEVDGPYLAMILPASKEMNKKLKKRYAVFNRDRSLAELKGFEVKRNGELNLIKIFQSSVFESFLKGSSISEVYQHVAIVANYWLDLLYSRASTMPDEELFELISEKRCMSKKLEEYGKQKSTSISTARRLAEFLGDEMVKDAGLSFKFIISKKPEGQQVTDRAIPVAIFQAEESVKRFYLSKWLKSKDLQDFDIRNILDWDYYINRFSSNIQKIITIPAALQEVPNPVPRVAHPDWLHKILMEKDNRFKQQRITDIFQTITPSQAAADKMKDIENCAPISKKKPTGVTSLKRARNKDTVDVYGVQLDMDNLPNHWRDILGDPVPKGNSKSQFIVWLEFHXXXXXXXXXXXDQSELSKENINPATVKRIKTVKKGIQSGISSFFTRSKQSILEDTWQIIQITDTNVSGIYRVWVLIGQEIHNMKLTVPRTFYVNTRIPKAPGENMYFKQVH------KLLPRSRIVYHLYEYNLDETIFIKHRSDILSEFIRNEVEGIYELEVPLLLRVYAKLGCMCSIDRNHFTDQQLSNNPSSFLLNELKFRSTA----QHPYLSPNS-IKTTFLFQQKSNRNEIIGWFDPCNNRAHLCLVEQSK----PNPDKFQANVVQSWFSREREAFLSLKENESLISVVPEHVQFEVSSHKFEISAFKAINKLLVAHRNEVTTPTFIATKSKMTINELYSNLPALQEYPLVPITINETDVSFNVLDWQRIAIKSALQNFVKYEKLLAEMLERARYLHIPVGNMSKFTNDYRGISDSYDLFYGRFLMKNNFIWWCNDKSEPDLGKKENQDRRMMLVDNDVLNGMIYRNKPGCYPTTCVQLEMTYFPINTIIAMHKVMEIDGTNERL-FESMIVPAKTIDQAMIQSKCNAAKRNLNLTSNTMYDDVTAAGPAFKILRNVILQWLDDVRNYKNPVADEHLMGFYKWMKNSRSLFYDPALFKSLQKLMRMVFFKLIEQLNNLGVEVIYGTLNKIVLCTKRTDLMDALVHVEYATKTVRNQDIFSQLDFQYVSGWDYLIWQDVSNYSGIKSDLESVTKEEHNSMVLEELSFVNMTNPSLSMGLSQSQNEDSFLTTEIADSSQIEMNWHLSRYLSPMSGVQLRLIEILQYFMLTNWKIVK--------DEYKLNRLAAKNDVAEEAV---NTGTILG----SDASLYPSSVQRMEDFLQNEMGYKLYLLVSQLKDVPRMH----NAVPLTTXXXXXXXXXXXSNK---TPPLLPLKNKVSLHPIVDLIKTTCHILALDTSARYYVNDWKRNMFKLINFDAYSDQAKWRSPYSSDQSMGDAFRSDLIITVPEVICDNCNVTRDLDLCR--DLYQVRIKNSWW---FVCPTCDFPYDRNVIQETLIDQVRCICESNVMQDLKCTKCTNGILETSLAGTENCVKCGNAIQVTQNAASLKEKIKIYADIGKHYDLPYLHMMTSWML 7001
            ++  FK+ TEK        + + +E     EE+   LK+ D+ID   GF      + R  WL+NM  T   D D+    S + +YF+E+D S FK+T+++QPYF +  + G ES ++ +L ++Y   + +I+   KEDL L NHL+G ++++L+L F  + DL+ VRKE++P  K  QK   + + Y+ +L+                          + + G +K    A  SALD  +  +DIREYD+PY++RV+ID  + +G WYDV     I   N        D V   +P+V+A+DIETTK PLKFPDA  D +MMISYMIDG G+LI NREI+++DIEDFE+TPR E+ GPF +FNEP+E   ++RFF H RE +P +  TYNGD FD+PF++ RA  HGL+M+  IGF+KD+ NEYKSR+  H+DCF+WVQRDSYLP G+QGLKAV  AKL Y+P+E+DPE M   A E P+TLA YSVSDAVATYYLYMKYVHPFIF+LC IIP++PDEVLRKGSGTLCE LLMV+AF  NII PN+ E   +P+ N   GH++ESETYVGGHVEA+E+GVFRSDI T F++ P   + L  +L   L   +  E K+ +D + N+DEV   I   LE + +  +R +CP+IYHLDVAAMYPNI+LS RLQP ++V+E  C  CD+N P  KC + M W WRGE  PA + E  +I+N L  E FPPK   L  R++ +LD  E+  +  +RLG + R  Y + H ++   R AV+CQREN FY++TVR FRDRRY+YK L K  KK LD+  +    D  E K+   M+VLYDSLQLAHKCILNSFYGYVMRKGARWYSMEMAGI C TGA+II+ A+E++++IGRPLELDTDGIWC+LP  FP+ F F+    KK  IS  YP  MLN +V + FTN QYH+LVD     Y +RSENSIFFE+DGPY AMILP+SKE +K LKKRYAVFN D SLAELKGFEVKR GEL LIK FQ  +FE FL G++++E Y  VA VAN WLD+LYS+ ST+ DEEL +LI+E + MSK L+EYG  KST+I+TA+RLAEFLG +M+KD GL+ KFIIS KP G  VT+RA+PVA+F AE SVK +YL K+L+   + DFDIRNILDW+YYI RF   IQK+ITIPAA+Q+V NPVPRV HPDWLHK +  ++++FKQ+++TD+F+        A K   IE C           T+LK A    + D+   + +++ +     DI  D          +  W+   KKKW+ Q++ + +   ++ N   A +    ++ KG    + S F++   ++    W I+QI  T+  G YR+W+ I Q + ++KL VPR FYVN +    P E+++   V+      K LPR     HLY   +DE ++ +  S   +      VEG+YE ++PL +R   +LG  C   RN    +      + F L +L   ++      H YLS  + I+  +L+    +   +I  F P      + +V+ +     PN +   A+ V     R +     L+E   +     + ++ +V  H     AFKAI K L + +        +A  +        S++P++ E+P++ I     +     L WQ  + +  LQ +++    +   ++ A +  +P+ NM K    +       D+ + R L+K + + W +    PDLG +E         D       +  +  G Y T C+++ +    +++++    V E++G+     FE     +  +D+           R    T+  + D V  +   F  ++ ++  W    R  ++P A      F++W  +  S  ++PAL + L  LM+    +L+ +   LG  ++Y + N++ L T +    +A+ +  Y    V ++++F  +    +  W+YL+W D +N+ G+ +D +S+                        +  +  Q +++    ++A +  +EMNW++  +L P++ VQ +    +  F+ + ++  +        +   L  +   N  A+      + G + G     D +    + +   D + + M  KL   +S+LK   +      NA     +D++  +     ++   + P+LP       +P+++ IKTT  +L+L       V+  KRN+  +I    +S +A++R+P                  +P VIC  CN  R LDLCR  DL      N      + C  C FPY+   ++  L++      ES  +QDL+C KC   + +T+L    +C +C  +  +        +++K    I + + L    M    ML
Sbjct:   28 RSGSFKSATEKAIANAAAQLVKGVEDGSAVEERFQELKERDEIDEKLGFHRLEQGQTRQAWLVNMHPTLLRDPDHPTGKSGVDFYFIEDDASMFKATVLYQPYFLVGCRPGTESSVEEWLRRRYEGLVQSIQRDRKEDLKLPNHLLGNQRLYLRLTFLNVQDLLSVRKELLPIAKAAQKKLSAVDTYADVLSAASAAASASLGIQLDSDGHNAALDPDDGWTGARK---RAAASALDPAECLVDIREYDIPYYLRVAIDQDVRVGLWYDVSFEDGIVSLNMV-----KDRVKRADPVVMAFDIETTKQPLKFPDAETDAVMMISYMIDGQGFLITNREIVSEDIEDFEYTPRDEYEGPFIIFNEPDELGVLQRFFSHFREARPTVVATYNGDLFDFPFIDARARAHGLNMMSEIGFAKDSDNEYKSRATAHLDCFRWVQRDSYLPQGSQGLKAVTVAKLGYDPMELDPELMTPYAIEQPQTLAQYSVSDAVATYYLYMKYVHPFIFSLCNIIPLNPDEVLRKGSGTLCETLLMVQAFKGNIIMPNRHE---DPVGNTYKGHLLESETYVGGHVEALEAGVFRSDIETDFRVDPAAIQQLIDDLDAALQFSIREEGKLDLDDIENYDEVKAEIRTMLEVMRDQPVRKDCPLIYHLDVAAMYPNIMLSYRLQPDSMVSEAMCATCDYNRPGMKCDKRMDWAWRGEYFPAKRDEVNMIRNALSNETFPPKAAHLARRTYDDLDPNERTALLHKRLGDYSRKVYRKTHESKTVIREAVICQRENPFYINTVRDFRDRRYEYKGLHKTWKKNLDK--ADSLNDTIEAKK---MIVLYDSLQLAHKCILNSFYGYVMRKGARWYSMEMAGITCLTGASIIQMAKELVDRIGRPLELDTDGIWCMLPGVFPENFNFKVKGGKKFGIS--YPCTMLNHLVHEKFTNHQYHELVDKQTGKYEVRSENSIFFELDGPYKAMILPSSKEEDKLLKKRYAVFNTDGSLAELKGFEVKRRGELQLIKDFQKQIFEKFLLGTTLNECYAAVAKVANQWLDVLYSKGSTLHDEELIDLIAENKSMSKTLQEYGSLKSTAITTAKRLAEFLGAQMIKDKGLACKFIISAKPFGAPVTERAVPVALFNAEPSVKHYYLKKFLRDNSITDFDIRNILDWNYYIERFGGVIQKLITIPAAMQKVSNPVPRVRHPDWLHKRVAAREDKFKQRKLTDVFR-------PAAKPTSIEAC-----------TTLKPAAAVASADIVENEPEVEEVAP---DITVD----------YSGWVAVMKKKWRKQRLQRAKERKARANGGGAFIS--SSLGKGT---VGSMFSKRSANMATAVWDIVQICATSRPGEYRLWISIDQHLQSLKLKVPRQFYVNFK--SQPSESVFLSGVYRAERLVKTLPRDAPCRHLYRITVDEDVYQEQESHFSNLIHHPNVEGVYEKQLPLDVRALIQLGSTCVYGRNSQAPKLSRALDTGFHLQDLSAPTSVDISPNHKYLSGGAGIRYFYLYHAHRDGRHVISLFSP-EGEIKMHIVDSAGLRQVPNVETMYADRVAHMRKRGK-----LEEGSGVFE-YSDTMRVDVRVHTSTTRAFKAITKELGSLKAAKQGSAMLALCTSKDQAYYESHIPSVAEFPIIKIAAAALEDELPALGWQLYSARRMLQCYLRASNWIRGWIDLASHFDLPLCNMEKDFTIF-----GADIDFARRLVKQDMVLWWSPHPRPDLGGREQDIHAQSRWDE---QESLEISHAGAYSTVCLEVGLVDLAVDSVLQSGSVNEMEGSTSGFAFEGA---SHNLDE---------YSRGTVETATILGDSVLTSA-VFAAVKGMVKAWYTTKRRNRSPYAALLSDNFWRWASSDGSALFEPALQRFLFGLMKKTLLQLLAEFKRLGASIVYASFNRLFLLTSKPTAANAMAYSRYLLTAVTSRELFKHVQLDIIHYWEYLLWMDTANFGGVIADTDSL------------------------VAPTDEQAQEASAANQVA-TFNVEMNWNIQTFL-PLA-VQEKFSVAVGSFIYSLYEYKRRAALAGEHERTPLRAVVEPNTPADPVTLHGDGGQVNGDGGKDDRTALAPAAKFTSDLINHTMTRKLLKHLSELKSSMQTSSDEINAAIARDEDEEYIDMLTTEHRRMWSFPVLPGSWLTPSNPLLEFIKTTNAVLSLAKDHAIEVSILKRNLLDMIKVREFSPEAEFRNPCEP-------------FKLPLVICTFCNDDRTLDLCRDADLMPSAASNGGGAPKWKCAKCQFPYNIAALEMRLVNTANAYLESFHLQDLRCNKC-GALKQTNL--QPHC-ECSGSFGLMVTRKETLKRLKSLKTIAEFHGLETTAMAVESML 2302
[Close]
BLAST of DNA polymerase epsilon catalytic subunit vs. UniProt/SwissProt
Match: sp|O93845|DPOE_EMENI (DNA polymerase epsilon catalytic subunit A OS=Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) OX=227321 GN=pol2 PE=3 SV=2)

HSP 1 Score: 1504.96 bits (3895), Expect = 0.000e+0
Identity = 821/1972 (41.63%), Postives = 1163/1972 (58.98%), Query Frame = 3 
Query:   51 NPTEKENDVFEAIERNE-----EKILRLKKNDQIDLVYGFDLHSAIKIRTGWLINMKTTDAIDDN-KRLVSAMSYYFLEEDGSKFKSTLIFQPYFYIVTKLGCESEIQTYLMKKYSACLHNIEIIEKEDLDLDNHXXXXXXXXXXXXXHTIDDLVRVRKEIMPKIKQNQKNQESDNDYSKMLTEHFQGEKKYEYNARKSALDIMDNAIDIREYDVPYHVRVSIDTAIFIGKWYDVHGSMNIKGPNSTHITPRSDIVDHPEPIVLAYDIETTKLPLKFPDATFDQIMMISYMIDGMGYLICNREIIADDIEDFEFTPRPEFPGPFSVFNEPNEKRTIERFFDHIREVKPNIFVTYNGDFFDWPFVETRAVKHGLDMLDYIGFSKDNQNEYKSRSAIHMDCFKWVQRDSYLPIGAQGLKAVCKAKLRYNPVEVDPEEMCKVAREDPRTLANYSVSDAVATYYLYMKYVHPFIFALCTIIPMDPDEVLRKGSGTLCECLLMVEAFNSNIIFPNKQESKLNPLTNDGHVIESETYVGGHVEAIESGVFRSDIPTKFKIVPEMCKFLRKNLKETLVHVLEVEEKVTVDSVLNFDEVYNAIDEKLEDLEETNIRFECPVIYHLDVAAMYPNIILSNRLQPSALVNEKTCGACDFNVPNAKCKRPMTWKWRGEIMPATKSEYYLIQNQLEKEKFPPKKPSLPMRSFYELDKLEQATVEKERLGKFCRNAYNRKHNTRFEERTAVVCQRENAFYVDTVRAFRDRRYQYKDLTKVSKKRLDELISSENGDASEIKRANGMLVLYDSLQLAHKCILNSFYGYVMRKGARWYSMEMAGIVCSTGAAIIKYAREMIEQIGRPLELDTDGIWCILPASFPQGFEFQTNNPKKRNISFSYPGAMLNLMVQQYFTNDQYHDLVDPAKHTYRIRSENSIFFEVDGPYLAMILPASKEMNKKLKKRYAVFNRDRSLAELKGFEVKRNGELNLIKIFQSSVFESFLKGSSISEVYQHVAIVANYWLDLLYSRASTMPDEELFELISEKRCMSKKLEEYGKQKSTSISTARRLAEFLGDEMVKDAGLSFKFIISKKPEGQQVTDRAIPVAIFQAEESVKRFYLSKWLKSKDLQDFDIRNILDWDYYINRFSSNIQKIITIPAALQEVPNPVPRVAHPDWLHKILMEKDNRFKQQRITDIF---------------------QTITPSQAAADKMKDIENCAPISKKKPTGVTSLKRARNKDTVDVYGVQLDMDNLPNHWRDILGDPVPKGNSKSQFIVWLEFHXXXXXXXXXXXDQSELSKENINPATVKRIKTVKKGIQSG---ISSFFTRSKQSILEDTWQIIQITDTNVSGIYRVWVLIGQEIHNMKLTVPRTFYVNTR---IPKAPGENMYFKQVHKLLPRSRIVYHLYEYNLDETIFIKHRSDILSEFIRNEVEGIYELEVPLLLRVYAKLGCMCSID---RNHFTDQQLSNNPSSFLLNELKFRSTAQHPYLSPNSIKTTFLFQQKSNRNEIIGWFDPCNNRAHLCLVEQSK-----PNPDKFQANVVQSWFSREREAFLSLKENESLISVVPEHVQFEVSSHKFEISAFKAINKLLVAHRNEVTTPTFIATKSKMTINELYSNLPALQEYPLVPITINETDVSFNVLDWQRIAIKSALQNFVKYEKLLAEMLERARYLHIPVGNMSKFTNDYRGISDSYDLFYGRFLMKNNFIWWCNDKSEPDLGKKENQDRRMMLVDNDVLNGMIYRNKPGCYPTTCVQLEMTYFPINTIIAMHKVMEIDGTNERLFESMIVPAKTIDQAMIQSKCNAAKRNLNLTSNTMYDDVTAAGPAFKILRNVILQWLDDVRNYKNPVADEHLMGFYKWMKNSRSLFYDPALFKSLQKLMRMVFFKLIEQLNNLGVEVIYGTLNKIVLCTKRTDLMDALVHVEYATKTVRNQDIFSQLDFQYVSGWDYLIWQDVSNYSG 5843
            NP   +   F ++  +E     EK   ++  + ID   GF    A + R GWLINM +T   D N     + + YYFL++DG  FK+T+ + PYF I  K G E+E++ +  + +   +  I+ + KEDL L NHL+G ++ FL+L F  +  L+ VRK ++P  ++N+KN                       N   +A D +   IDIREYDVPYHVRV+ID  I IGKWY V  +  I       +T   + +   +P+VLA+DIETTKLPLKFPD+  DQIMMISYMIDG G+LI NREI+++DI+DFE+TP+PE+ GPF +FNEPNE+  IERFF+HI+E KP +  TYNGDFFDWPFVE RA   G+DM   IGF K++++ Y+S    HMDCF WV RDSYLP G++GLKAV  AKL Y+P E+DPE M   A E P+TLA YSVSDAVATYYLYMKY+HPFIF+LCTI+P++PD+ LRKG+GTLCE LLMV+A+  NI+ PNK +        +GH++ESETYVGGHVE+IE+GVFRSDIP  F I P     L ++L   L   +EVEEK ++D V N++EV   I + L DL E   R E P IYHLDVA+MYPNI+++NRLQP +L+ E  C ACDFN P   C R + W WRGE +PA + EY +I+  ++ E+FP +    PMR+F EL   EQA + K+RL  + +  Y++ H+++   R A++CQREN FYVDTVR+FRDRRY +K   KV K + + L SS    A+EI+ A  M+VLYDSLQLAHK ILNSFYGYVMRKG+RWYSMEMAG+ C TGA II+ ARE++E+IGRPLELDTDGIWC+LP +FP+ F F   N KK  I  SYP  MLN +V   +TN QY  L +PA   Y   SENSIFFEVDGPY AMILP SKE +K LKKRYAVFN D SLAELKGFEVKR GEL LIKIFQ+ +F+ FL+G++++E Y  VA VA+ WLD+LY   +T+ DEEL ELISE R M+K LEEYG QKSTSI+TARRLAEFLG++MVKD GL+ K+IIS +P    VT+RAIPV IF AE+S+KR +L KWLK  D  D D R+++DWDYY+ R  S +QK+ITIPAALQ++ NPVPRVAHP+WL + + ++D+RFKQ ++TD+F                           +A AD M+ +++ +P   +K +G       + K ++D +       +LP     I  D          ++ +L+                +   +    A ++R +   +   +G   +S  F    + +   TWQ++Q+ +T+  GI R +VLI ++IH + + VPR  Y+N +   +P         ++V+  LP      HL++  L E  F++    I        VEG+YE  +PL LR   KLG +C+ D   R    D         F L+ L  R++++  YL  + +   FL+   S   +I   F    N AH+ ++ +++     PN DK  + ++      + +      + +       E + F  +       A+  ++ L+   RN+ + P  +  +S+   + L  ++P L+EYP++ +    +D++   L WQ    K  + +++     +  +   ARY  +P+ N+   ++D R +    D+ Y R L +NN + W +  ++PD    E  D    +       GM   N PG Y T CV+LE+    INTI+    + E +G +     S++ P+    ++                S  +Y +   A     +LR ++  W  +     N +AD  +    +W+++  S  YD +L + ++ L R  F +L+ +   +G  V++ +  +++L T +T++ +A  + +Y  K++R    F  +D      WDYL+W D  NY G
Sbjct:   21 NPKRTKTVEFSSLRSSEATSQDEKFEAIRLANSIDESLGFPRFEAGEKRVGWLINMHSTSIEDPNVPGGRAGVDYYFLDDDGGSFKATVEYDPYFLIAVKTGHEAEVEEWCRRMFEGLIKKIKRVVKEDLKLPNHLLGHRRTFLQLDFANVSHLLEVRKTLLPLAEKNRKNARP--------------------NGTTNASDFI---IDIREYDVPYHVRVAIDKDIRIGKWYTVEATHGI-----ISLTCLEERLTRADPVVLAFDIETTKLPLKFPDSVIDQIMMISYMIDGQGFLITNREIVSEDIDDFEYTPKPEYSGPFMIFNEPNERAVIERFFEHIKEAKPTVIATYNGDFFDWPFVEARASVLGIDMYKEIGFRKNSEDIYQSDHCAHMDCFAWVNRDSYLPQGSRGLKAVTVAKLGYDPDELDPELMTPYASERPQTLAEYSVSDAVATYYLYMKYIHPFIFSLCTILPLNPDDTLRKGTGTLCEMLLMVQAYKGNIVLPNKHKDPPEAFY-EGHLLESETYVGGHVESIEAGVFRSDIPVPFNIDPTAVDELLRDLDAALKFSIEVEEKKSLDDVTNYEEVKGQIAKLLTDLRENPHRNEVPFIYHLDVASMYPNIMITNRLQPDSLIQESNCAACDFNRPGKTCDRRLPWAWRGEFLPAKRDEYNMIRQAVQNERFPGRTKKSPMRAFTELSAEEQAAIVKKRLQDYSKKIYHKIHDSKTMVREAIICQRENPFYVDTVRSFRDRRYDFKGKQKVWKGKTESLKSS-GAPAAEIEEAKKMIVLYDSLQLAHKVILNSFYGYVMRKGSRWYSMEMAGVTCLTGARIIQMARELVERIGRPLELDTDGIWCMLPGTFPENFSFTLKNGKKLGI--SYPCVMLNHLVHGSYTNHQYQSLANPATFRYETHSENSIFFEVDGPYRAMILPTSKEEDKNLKKRYAVFNDDGSLAELKGFEVKRRGELKLIKIFQTQIFKFFLEGTTLAETYAAVARVADRWLDVLYEHGATLADEELIELISENRSMTKTLEEYGNQKSTSITTARRLAEFLGEQMVKDKGLNCKYIISARPRNTPVTERAIPVTIFSAEDSIKRHFLRKWLKD-DPGDMDPRSVIDWDYYLERLGSVVQKLITIPAALQKIRNPVPRVAHPEWLQRRINKQDDRFKQVKMTDMFGKSEKNPLSDISTNIIDHRVQHADNLDEAMADSMEKLKSSSP---QKASGKRKHPENQTKTSLDPFA------SLPAKMPSIDDD----------YVGFLK--------------YQKQKWKIQKQARLRRRQLFGERANTGGDSLSHLFRNQAELLYISTWQVLQLAETSRPGIVRAFVLIDRKIHALTIKVPRCVYINLKQDSLPDVEVPECEVEKVNHTLPNGHPSVHLFKLTLSEETFLREADKIHVLLQHPSVEGVYERNIPLNLRAVLKLGSICTFDEAQRGVLGD----GLERGFDLSTL-CRTSSEQQYLQDSPLAYHFLYHVSSGEKQIFAIFSSTKNEAHIVILNRARDVQGLPNVDKIYSELLARKLQGQGDQAEGAFQYQ-------EKIHFRTTQITTRRKAYLEVSDLIKKLRNDESLPAIMIIQSQQR-SRLCHDIPILKEYPILSVKPEVSDMNLPPLGWQSFIAKRLVTHYLYLSSWVQHLTMLARYGDVPLCNLE--SDDPRFL---IDISYARRLQQNNVVLWWSSTAKPDHAGYEKDD----ITGPLERVGMPCVNVPGSYTTVCVELEVRNLAINTILTSSIINEAEGAD-----SLLAPSDPSAESS--------------GSGVLYSEKAFASAGAVVLREMVKHWWSEACQGNN-MADIMVQHLIRWVESPASCLYDRSLHQYVRMLSRKSFQQLMAEFRRVGSNVVFASPTRLLLQTSKTEVGNAYAYSQYVLKSIRANPSFHFIDLDIKEYWDYLVWYDEYNYGG 1884

HSP 2 Score: 79.337 bits (194), Expect = 4.504e-13
Identity = 59/218 (27.06%), Postives = 101/218 (46.33%), Query Frame = 3 
Query: 6378 PPLLPLKNKVSLHPIVDLIKTTCHILALDTSARYYVNDWKRNMFKLINFDAYSDQAKWRSPYSSDQSMGDAFRSDLIITVPEVICDNCNVTRDLDLCRDLYQVRIKNSWW----------FVCPTCDFPYDRNVIQETLIDQVRCICESNVMQDLKCTKCTNGILETSLAGTENCVKCGNAIQVTQNAASLKEKIKIYADIGKHYDLPYLHMMTSWML 7001
            P +L   N+   +P+++L+K    +L+L  +        +R +  L     +S + ++ +P SS             + +PE+ C  C + RDLDLCRD   +  + S            + CP C   YDR   +E LI QV  +  +   QDLKC+KC  G L+ S    E+C  C      T N A +++++K+   + K ++L  L ++   +L
Sbjct: 2004 PGVLTDPNEEKRNPVLELVKLLMQVLSLSKTTALETRLLRRELLALFEVREFSKEGRFENPGSS-------------LKIPELTCSACCLIRDLDLCRDEDVLPERGSGSGPDSATSSRPWCCPFCQTEYDRLAQEEMLIGQVWGMVVAWQTQDLKCSKC--GTLKIS-EFMEHC-SCSGQWTETMNRADIEKRLKVLESVAKFHELKLLQVVVEEVL 2204
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BLAST of DNA polymerase epsilon catalytic subunit vs. TrEMBL
Match: V4A1X9 (DNA polymerase epsilon catalytic subunit OS=Lottia gigantea OX=225164 GN=LOTGIDRAFT_217825 PE=3 SV=1)

HSP 1 Score: 2174.82 bits (5634), Expect = 0.000e+0
Identity = 1111/2330 (47.68%), Postives = 1542/2330 (66.18%), Query Frame = 3 
Query:   90 ERNEEKILRLKKNDQIDLVYGFDLHSAIKIRTGWLINMKTTDAIDDNKRLVSAMSYYFLEEDGSKFKSTLIFQPYFYIVTKLGCESEIQTYLMKKYSACLHNIEIIEKEDLDLDNHXXXXXXXXXXXXXHTIDDLVRVRKEIMPKIKQNQKNQESDNDYSKMLTEHFQGEKKYEYNARKSALDIMDNAIDIREYDVPYHVRVSIDTAIFIGKWYDVHGSMNIKGPNSTHITPRSDIVDHPEPIVLAYDIETTKLPLKFPDATFDQIMMISYMIDGMGYLICNREIIADDIEDFEFTPRPEFPGPFSVFNEPNEKRTIERFFDHIREVKPNIFVTYNGDFFDWPFVETRAVKHGLDMLDYIGFSKDNQNEYKSRSAIHMDCFKWVQRDSYLPIGAQGLKAVCKAKLRYNPVEVDPEEMCKVAREDPRTLANYSVSDAVATYYLYMKYVHPFIFALCTIIPMDPDEVLRKGSGTLCECLLMVEAFNSNIIFPNKQESKLNPLTNDGHVIESETYVGGHVEAIESGVFRSDIPTKFKIVPEMCKFLRKNLKETLVHVLEVEEKVTVDSVLNFDEVYNAIDEKLEDLEETNIRFECPVIYHLDVAAMYPNIILSNRLQPSALVNEKTCGACDFNVPNAKCKRPMTWKWRGEIMPATKSEYYLIQNQLEKEKFPPKKPSLPMRSFYELDKLEQATVEKERLGKFCRNAYNRKHNTRFEERTAVVCQRENAFYVDTVRAFRDRRYQYKDLTKVSKKRLDELISSENGDASEIKRANGMLVLYDSLQLAHKCILNSFYGYVMRKGARWYSMEMAGIVCSTGAAIIKYAREMIEQIGRPLELDTDGIWCILPASFPQGFEFQTNNPKKRNISFSYPGAMLNLMVQQYFTNDQYHDLVDPAKHTYRIRSENSIFFEVDGPYLAMILPASKEMNKKLKKRYAVFNRDRSLAELKGFEVKRNGELNLIKIFQSSVFESFLKGSSISEVYQHVAIVANYWLDLLYSRASTMPDEELFELISEKRCMSKKLEEYGKQKSTSISTARRLAEFLGDEMVKDAGLSFKFIISKKPEGQQVTDRAIPVAIFQAEESVKRFYLSKWLKSKDLQDFDIRNILDWDYYINRFSSNIQKIITIPAALQEVPNPVPRVAHPDWLHKILMEKDNRFKQQRITDIF-------QTITPSQAA----ADKMKDIENCAPISKKKPTG-----VTSLKRAR---NKDTVDVYGVQLDMDNLPNHWRDILGDPVPKGNSKSQFIVWLEFHXXXXXXXXXXXDQSELSKENINPATVKRIKTVKKGIQSGISSFFTRSKQSILEDTWQIIQITDTNVSGIYRVWVLIGQEIHNMKLTVPRTFYVNTRIPKAPGENMYFKQVHKLLPRSRIVYHLYEYNLDETIFIKHRSDILSEFIRNEVEGIYELEVPLLLRVYAKLGCMCSIDRNHFTDQQLSNNPSSFLLNELKFRSTAQHPYLSPNSIKTTFLFQQKSNRNEIIGWFDPCNNRAHLCLVEQSKPNPDKFQANVVQSWFSREREAFLSLKENESLISVVPEHVQFEVSSHKFEISAFKAINKLLVAHRNEVTTPTFIATKSKMTINELYSNLPALQEYPLVPITINETDVSFNVLDWQRIAIKSALQNFVKYEKLLAEMLERARYLHIPVGNMSKFTNDYRGISDSYDLFYGRFLMKNNFIWWCNDKSEPDLGKKENQDRRMMLVDNDVLNGM--IYRNKPGCYPTTCVQLEMTYFPINTIIAMHKVMEIDGTNERL-FESMIVPAKTIDQAMIQSKCNAAKRNLNLTSNTMYDDVTAAGPAFKILRNVILQWLDDVRNYKNPVADEHLMGFYKWMKNSRSLFYDPALFKSLQKLMRMVFFKLIEQLNNLGVEVIYGTLNKIVLCTKRTDLMDALVHVEYATKTVRNQDIFSQLDFQYVSGWDYLIWQDVSNYSGIKSDLES--VTKEEHNSMVLEELSFVNMTNPSLSMGLSQSQNEDSFLTTEIADSSQIEMNWHLSRYLSPMSGVQLRLIEILQYFMLTNWKIVKDEYKLNRLAAKNDVAEEAVNTG-TILGSDASLYPSSVQRMEDFLQNEMGYKLYLLVSQLKDVPRMHNAVPLTTXXXXXXXXXXXSNKTPPLLPLKNKVSLHPIVDLIKTTCHILALDTSARYYVNDWKRNMFKLINFDAYSDQAKWRSPYSSDQSMGDAFRSDLIITVPEVICDNCNVTRDLDLCRDLYQVRIKNSWWFVCPTCDFPYDRNVIQETLIDQVRCICESNVMQDLKCTKCTNGILETSLAGTENCVKCGNAIQVTQNAASLKEKIKIYADIGKHYDLPYLHMMTSWMLQ 7004
            +  E+++ +  +ND+IDL +G++ +   +  TGWLINM  TD +D NKRL+SA+ YYFL+EDG +FK+TL F+PYFY++TK  CE E+ ++L +K+S  +  IE + KEDLDL NHL+GLK+  LKL F ++++L +V++E+   IK+N++ +++++ Y+ MLT H  GE   E +  K   D M+N +DIREYDVPYHVRVSID  IF+G WY + G    +G     IT R D+VD P+P+VLAYDIETTKLPLKFPD+  DQIMMISYMIDG GYLICNREII+ D+EDFE+TPRPEF GPF +FNEP+E  TI+RF DHI EVKP+I+VTYNGDFFDWPFVE RA  HG+D+   IG +KD Q EYKSR++IHMDCFKWV+RDSYLP+G+Q LKAV KAKLRY+PVE+DPEEMC++A E P+ +ANYSVSDAVATYYLYMKYVHPFIFALCTIIPM PDEVLRKGSGTLCE LLMV+A+++NI+FPNKQES LN LT+DGHV++SETYVGGHVEAIESGV+R+D+PT+F++VPE  + L  N+  T+   +EVEEK+ +D V NF E+ + + EKL  L +   R E P+IYHLDV AMYPNIIL+NRLQP A+V+E TC ACDFN P AKC+R ++W WRGE MPA+++E++ IQ QLE EKFPP  P    R+F++L++ EQAT+EK+RL  +CR AY +  +TR EER A VCQREN+FYVDTVRAFRDRRY++K LTKV K +L +  + +  DA+EIK+ANGM+VLYDSLQLAHKCILNSFYGYVMRKGARWYSMEMAGIVC TGA II  ARE++EQIGRPLELDTDGIWCILPA+FP+ +  ++ NPKK  ++ SYPGAMLN+MV+  FTNDQY +L DP    Y +RSENSIFFEVDGPYLAMILPASKE  KKLKKRYAVFN D SLAELKGFEVKR GEL LIKIFQSSVFE+FLKG ++ E Y+ VA +A+YWLD+LYS+A+ MPD ELFELI+E R MSKKLEEYG QKSTSISTA+RLAEFLGD+MVKDAGLS +++ISKKPEG  VT+RAIP+AIFQAE S+KR YL KWLK +DL DFDIR ILDW YYI R    IQKIITIPAALQ VPNPVPR+ HPDWL K L+E+++ FKQ++I+++F       Q +  SQ A     + +KDIE+   I  K   G       S KR R     D++D+     +     N WR+ LG P P G +K +  +W+E+HKKKW++Q   K   +  +  ++ +T       +     G+  F  ++ +S+++  WQI+Q+ +T+  G +++W LIG ++H MKL VPR FYVN + PK  GE   +K+  K LPRS  V++LY+Y++ E ++++H +DI ++    ++EG+YE +VPL  R   +LGC+ +++R  F  Q       +F ++ L FR+ AQ PYL   SIK  + +       ++ G F P + +  + +V+  + +    Q   + + ++ ER   ++   +E   S+ P    FE    K     ++ I ++L A+++E   PTFIA +S +    L S +P L ++PLVPI I ++D  +NVLDWQR+  +   Q+++  + +L  M+E+ RYLHIP+GNM K    Y       DLF+ R L K+N + WC+    PDLG KE  D R+ +     L G   I  N PG YPT CV+L++T   +NTII    V + +G +  + F++M  P  +++  M+Q +  A       T  T YD+       F+IL+ ++  W+ DV  Y N  AD  ++ FY+W+++  SL YDPAL ++L  +M+ VF +LI +   LG E++YG  N+++LCTK+  L+DAL +VEY T +++++++F  +D  Y   W+ L+W D +NY G++  L         ++    +  S            L++S +E         D  ++EMNW++  +L      Q     ++  ++L+ +  + +E +  R    N       ++  T +  D S  PS++   ++ +Q E+  +++ L  +++          L+ +  +  + E         LPL N     P ++ +K  C +L+LD++    VN  KR++ KLI    +S +++++ P              L   +PEVIC +CN  RDLDLCRD Y  +      + C  C   YD + I+++L++ +     S ++QDLKC+KC  GI + ++   +    C      T +    +++++ +  I +HY +  L     W+++
Sbjct:   14 DSTEKRLQKANQNDEIDLRFGYERYKDPQEITGWLINMHPTDILDGNKRLISAVDYYFLQEDGGRFKATLPFKPYFYVITKKDCEREVASFLTRKFSGKISAIESVTKEDLDLANHLVGLKRKMLKLSFLSVEELNKVKREVFSAIKKNKEREKANDAYTSMLTSHLTGE---ENSVSKKLSDQMENMMDIREYDVPYHVRVSIDKEIFVGHWYTIRG----RGSEPPEITRRDDLVDRPDPVVLAYDIETTKLPLKFPDSATDQIMMISYMIDGQGYLICNREIISQDVEDFEYTPRPEFEGPFIIFNEPDEIATIQRFIDHILEVKPHIYVTYNGDFFDWPFVEARAGFHGIDLEREIGVTKDTQGEYKSRTSIHMDCFKWVKRDSYLPVGSQNLKAVAKAKLRYDPVELDPEEMCRLASEQPQVMANYSVSDAVATYYLYMKYVHPFIFALCTIIPMQPDEVLRKGSGTLCEALLMVQAYHANIVFPNKQESILNRLTDDGHVLDSETYVGGHVEAIESGVYRADVPTRFRMVPEAFQTLIDNVDRTMKFCIEVEEKIPIDQVTNFQEICDDVKEKLAMLRDCPNRLENPIIYHLDVGAMYPNIILTNRLQPPAIVDEATCAACDFNKPGAKCQRDLSWMWRGEFMPASRNEFHRIQQQLENEKFPPFFPGGEQRAFHQLNREEQATIEKKRLADYCRKAYKKTKSTRMEERVATVCQRENSFYVDTVRAFRDRRYEFKGLTKVWKGKLSD--AEKKKDAAEIKKANGMVVLYDSLQLAHKCILNSFYGYVMRKGARWYSMEMAGIVCYTGANIICRAREIVEQIGRPLELDTDGIWCILPATFPENYVVKSTNPKKSKVTISYPGAMLNIMVKDVFTNDQYQELEDPVAMKYSVRSENSIFFEVDGPYLAMILPASKEEGKKLKKRYAVFNFDGSLAELKGFEVKRRGELQLIKIFQSSVFEAFLKGKTLEECYEAVAKIADYWLDVLYSKAANMPDSELFELIAENRSMSKKLEEYGSQKSTSISTAKRLAEFLGDQMVKDAGLSCRYVISKKPEGAPVTERAIPLAIFQAEPSIKRHYLRKWLKRQDLNDFDIREILDWQYYIERLGGTIQKIITIPAALQSVPNPVPRIPHPDWLRKKLLERNDVFKQKKISEMFSVSARPVQDLVYSQGAIPSSQNGVKDIED---IGNKGHNGNKNGMAISHKRKRIQSGNDSMDLTDSTQNTQQSQN-WREALGPPPPMGKTKEERKIWVEYHKKKWELQAKEKQDRKRQRTELDISTSMSTTPAR-----GLGGFLRKTARSMMDMPWQIVQLAETSNPGQFKLWALIGSDLHAMKLVVPRIFYVNQKTPKQ-GEGELWKKSIKTLPRSHPVFNLYQYSVPEDVYLQHINDINADLSSPDIEGVYETQVPLEFRALIQLGCVVTVNR-EFARQMSGRETDTFEMDNLDFRTLAQFPYLETGSIKHLYFYHHACGTKQLYGLFLPMSKKGTVFVVDTVRSD----QMPNITALYNAERNNKVTKGADED--SLPPAGHTFEYKLEKDIRQVYRTIQRMLSAYKDEKRGPTFIAVQSSLDFAHLVSVIPGLTDFPLVPIHIADSDNLYNVLDWQRVGCRRLFQHYLNVDIILQAMMEQCRYLHIPIGNMPKDITLY-----GCDLFFARHLYKHNHLLWCSPTERPDLGGKEADDNRLCM----ELQGSTPIELNNPGHYPTVCVELDITSLAVNTIIESGHVNDQEGASAAISFDTM--PQSSLED-MVQGQGAA-------TMLTSYDETALCSTTFRILKTMVHGWVRDVTTYSNVFADNQIIHFYRWLRSPSSLLYDPALRRTLHNMMKKVFMQLIAEFKRLGSEIVYGNFNRLILCTKKRQLVDALSYVEYITNSIKSRELFHLIDMSYEQCWELLMWLDQANYGGVRGKLTQNNNNNNNNDDKKDDGDSDGEEIVAEQEEELNKSDSE---------DEPEVEMNWNMMLFLPESGACQTNFNMLIAGYILSVYNQMLEEQR--RFTPGNTPLHNRFDSSQTPVVIDTSATPSTITFSQNLVQGELAQQMFALTQKVQK--------KLSGNRSNHGDIEKFPQLPGSHLPLNN-----PALEFVKCVCKVLSLDSNVTIQVNKLKRDLLKLICVGEFSSESQYQDPC-------------LSYILPEVICKSCNHVRDLDLCRDPYLCQDSPGSSWACIQCHLEYDISEIEQSLLEAINRKSMSYILQDLKCSKC-KGIKDNNM---KKYCSCAGEFSNTLDIEEYRKQLRTFRGIARHYKMVLLLETVEWIMK 2257
[Close]
BLAST of DNA polymerase epsilon catalytic subunit vs. TrEMBL
Match: I3K7A9 (DNA polymerase epsilon catalytic subunit OS=Oreochromis niloticus OX=8128 GN=pole PE=3 SV=1)

HSP 1 Score: 2165.96 bits (5611), Expect = 0.000e+0
Identity = 1097/2314 (47.41%), Postives = 1533/2314 (66.25%), Query Frame = 3 
Query:  102 EKILRLKKNDQIDLVYGFDLHSAIKIRTGWLINMKTTDAIDDNKRLVSAMSYYFLEEDGSKFKSTLIFQPYFYIVTKLGCESEIQTYLMKKYSACLHNIEIIEKEDLDLDNHXXXXXXXXXXXXXHTIDDLVRVRKEIMPKIKQNQKNQESDNDYSKMLTEHFQGEKKY---EYNARKSALDIMDNAIDIREYDVPYHVRVSIDTAIFIGKWYDVHGSMNIKGPNSTHITPRSDIVDHPEPIVLAYDIETTKLPLKFPDATFDQIMMISYMIDGMGYLICNREIIADDIEDFEFTPRPEFPGPFSVFNEPNEKRTIERFFDHIREVKPNIFVTYNGDFFDWPFVETRAVKHGLDMLDYIGFSKDNQNEYKSRSAIHMDCFKWVQRDSYLPIGAQGLKAVCKAKLRYNPVEVDPEEMCKVAREDPRTLANYSVSDAVATYYLYMKYVHPFIFALCTIIPMDPDEVLRKGSGTLCECLLMVEAFNSNIIFPNKQESKLNPLTNDGHVIESETYVGGHVEAIESGVFRSDIPTKFKIVPEMCKFLRKNLKETLVHVLEVEEKVTVDSVLNFDEVYNAIDEKLEDLEETNIRFECPVIYHLDVAAMYPNIILSNRLQPSALVNEKTCGACDFNVPNAKCKRPMTWKWRGEIMPATKSEYYLIQNQLEKEKFPPKKPSLPMRSFYELDKLEQATVEKERLGKFCRNAYNRKHNTRFEERTAVVCQRENAFYVDTVRAFRDRRYQYKDLTKVSKKRLDELISSENGDASEIKRANGMLVLYDSLQLAHKCILNSFYGYVMRKGARWYSMEMAGIVCSTGAAIIKYAREMIEQIGRPLELDTDGIWCILPASFPQGFEFQTNNPKKRNISFSYPGAMLNLMVQQYFTNDQYHDLVDPAKHTYRIRSENSIFFEVDGPYLAMILPASKEMNKKLKKRYAVFNRDRSLAELKGFEVKRNGELNLIKIFQSSVFESFLKGSSISEVYQHVAIVANYWLDLLYSRASTMPDEELFELISEKRCMSKKLEEYGKQKSTSISTARRLAEFLGDEMVKDAGLSFKFIISKKPEGQQVTDRAIPVAIFQAEESVKRFYLSKWLKSKDLQDFDIRNILDWDYYINRFSSNIQKIITIPAALQEVPNPVPRVAHPDWLHKILMEKDNRFKQQRITDIFQTITPSQAA-----ADKMKDIENCA-PISKKKPTGVTSLKRARNKDTVDVYGVQLDMDNLPNHWRDILGDPVPKGNSKSQFIVWLEFHXXXXXXXXXXXDQSELSKENIN-PATVKRIKTVKKGIQSGISSFFTRSKQSILEDTWQIIQITDTNVSGIYRVWVLIGQEIHNMKLTVPRTFYVNTRIPKAPGENMYFKQVHKLLPRSRIVYHLYEYNLDETIFIKHRSDILSEFIRNEVEGIYELEVPLLLRVYAKLGCMCSIDRNHFTDQQLSNNPSSFLLNELKFRSTAQHPYLSPNSIKTTFLFQQKSNRNEIIGWFDPCNNRAHLCLVEQSKPNPDKFQANVVQSWFSREREAFLSLKENESLISVVPEHVQFEVSSHKFEISAFKAINKLLVAHRNEVTTPTFIATKSKMTINELYSNLPALQEYPLVPITINETDVSFNVLDWQRIAIKSALQNFVKYEKLLAEMLERARYLHIPVGNMSKFTNDYRGISDSYDLFYGRFLMKNNFIWWCNDKSEPDLGKKENQDRRMMLVDNDVLNGMIYRNKPGCYPTTCVQLEMTYFPINTIIAMHKVMEIDGTNERLFESMIVPAKTIDQAMIQSKCNAAKRNLNLTSNTMYDDVTAAGPAFKILRNVILQWLDDVRNYKNPVADEHLMGFYKWMKNSRSLFYDPALFKSLQKLMRMVFFKLIEQLNNLGVEVIYGTLNKIVLCTKRTDLMDALVHVEYATKTVRNQDIFSQLDFQYVSGWDYLIWQDVSNYSGIKSDLES--VTKEEHNSMVLEELSFVNMTNPSLSMGLSQSQNEDSFLTTEIADSSQIEMNWHLSRYLSPMSGVQLRLIEILQYFMLTNWKIVKDEYKLNRLAAKNDVAEEAVNTGTILGSDASLYPSSVQRMEDFLQNEMGYKLYLLVSQLKDVPRMHNAVPLTTXXXXXXXXXXXSNKTPPLLPLKNKVSLHPIVDLIKTTCHILALDTSARYYVNDWKRNMFKLINFDAYSDQAKWRSPYSSDQSMGDAFRSDLIITVPEVICDNCNVTRDLDLCRD--LYQVRIKNSWWFVCPTCDFPYDRNVIQETLIDQVRCICESNVMQDLKCTKCTNGILETSLAGTENCVKCGNAIQVTQNAASLKEKIKIYADIGKHYDLPYLHMMTSWML 7001
            +++ R +  D++D  +GFD       +TGWLINM   + +D++KR++SA+ YYF++EDGS+FK +L F+PYFYI TK  CE E+ +YL KK+   +  +EI+ KEDLDL NHL+GLK+ ++KL F+T+DDLV+V++EI P +++N++ ++S++ Y+ ML+    G       E    KS  D +DN +D+REYDVPYHVRVSID  I +  WY+V    +   P    I  R D+V+ P+P+VLA+DIETTKLPLKFPDA  DQIMMISYMIDG G+LI NREI++++IEDFEFTP+PE+ GPF+VFNE NE   I+R+FDH++E KPNIFVTYNGDFFDWPF+E RA  HGL M   IGF KDNQ EYK+  AIHMDC +WV+RDSYLP+G+  LKA  KAKL Y+PVE+DPEEMC++A E+P+TLA YSVSDAVATYYLYMKYVHPFIFALCTIIPM+PDEVLRKGSGTLCE LLMV+AF++NIIFPNKQE   N LT+DGHV++SETYVGGHVEA+ESGVFRSDIP +FK+ P    FL + ++ T+ H +E EEK+ ++ V NF+EV + I +KL  L+E   R ECP+IYHLDV AMYPNIIL+NRLQPSA+V+E TC ACDFN P A C+R MTW+WRGEIMPA++SE++ IQ QLE EKFPP  P+ P R+F+ L + EQA  EK+RL  +C+ AY + H T+ EER   +CQREN+FYVDTVRAFRDRRY++K L KV KK+L    + ++GDA+E+KR   M +LY+SLQLAHKCILNSFYGYVMRKGARWYSMEMAGIVC TGA II  ARE+IEQIGRPLELDTDGIWC+LP +FP+ F  +T+N KK  ++ SYPGAMLN+MV++ FTNDQYH+LVDPA  TY IR+ENSIFFEVDGPYLAMILPASKE  KKLKKRYAVFN D SLAELKGFEVKR GEL LIKIFQSSVFE+FLKG+++ EVY  VA VA+YWLD+LYS+A+ MPD ELF+LISE R MS+KLE+YG+QKSTSISTA+RLAEFLGD+MVKDAGLS +++IS+KPEG  VT+RAIP+AIFQAE SVK+ +L KWLK   L D DIR+ILDW YYI R  S IQKIITIPAALQ+V NPVPRV HPDWLHK L+EK++ +KQ++I+++F +    Q A     A    DIE+   P    +P  + S KR R     D      D++ L   WR+ILG P PKG ++ +  VWL +HKKKW++Q   + + +  +  ++  A       ++ G  +G+ SF  R+ +SIL+  WQI+QI +T+  G+Y++W +IG ++H MKL +PR FYVN ++PK   E   +K+V+++LPRS +VY+LYEY++ E ++ +H ++I ++    ++EG+YE +VPLL R   +LGC+C +++ H           +F L  L+ RS AQ  YL P S++  +L+        + G F P   +A + +++  + N    Q   + + ++ ER A L  K  E L+   PE   FEV +     +  +A+ ++L+ ++ E   PT IA +S   +  L + +P L+E+P+VP+ + + ++S+NVLDWQR+  +  +++++  +  L++  + ARY H+PVGN+ +  + +       DLF  R L K+N + W +  S PDLG KE  D R+++ ++D   G +  N  GCY T CV+L++    +NTI+    V +++G       S+ V    I QA ++   +  +    L S   YD+       F+IL+++++ W+ ++  Y N  AD  +M FY+W+++  SL YDPAL ++L  +M+ VF +L+ +   LG  V+YG  N+I+LCTK+  + DA+ +VEY T ++ +++IF  L   +   W++L+W D +NY G+K  L S  +  EE            +          +  + +    T E+ D   IE NW++ +YL   +  Q   + I+  ++   +  +K+E + N   A                 D S  P  +   ++++ +E+   ++ +  +++       +V  T++               P+LP  +    +P ++ IK  C +L+LD +    VN  KR++ +L++   +SD+A++R P +S               +PEVIC +CN  RDLDLC+D  + Q       WF C  C   YD N I+  L++ ++    S  +QDL C+KC  G+ ETS+       KC     +T +A S  E+I ++ +I  HY++ +L     W+L
Sbjct:   32 KRLERSQFTDEMDARFGFDRMKEPGEKTGWLINMHPAEILDEDKRMISAVDYYFIQEDGSRFKVSLPFKPYFYIATKKNCEREVISYLSKKFQGKVAKLEILPKEDLDLPNHLVGLKRNYIKLAFNTVDDLVKVKREIAPAVRKNREREQSNDAYTSMLSSALSGGNVTSVDEDGMSKSISDQLDNIVDMREYDVPYHVRVSIDLKIHVAHWYNVRYRGSAYPPE---IVRRDDLVERPDPVVLAFDIETTKLPLKFPDAETDQIMMISYMIDGQGFLITNREIVSENIEDFEFTPKPEYEGPFTVFNEDNEAALIQRWFDHVQETKPNIFVTYNGDFFDWPFIEVRAALHGLSMHREIGFQKDNQGEYKASQAIHMDCLRWVKRDSYLPVGSHNLKAAAKAKLGYDPVELDPEEMCRMATEEPQTLATYSVSDAVATYYLYMKYVHPFIFALCTIIPMEPDEVLRKGSGTLCEALLMVQAFHANIIFPNKQEQIFNKLTDDGHVLDSETYVGGHVEALESGVFRSDIPCRFKMNPAAFDFLLQRVERTMRHAVEEEEKIPLEQVTNFNEVCDEIKKKLTSLKEVPNRIECPLIYHLDVGAMYPNIILTNRLQPSAMVDEATCAACDFNKPGATCQRRMTWQWRGEIMPASRSEFHRIQQQLESEKFPPLFPNGPPRAFHTLTREEQAKHEKKRLADYCKKAYKKTHVTKLEERVTTICQRENSFYVDTVRAFRDRRYEFKGLHKVWKKKLSS--AQDSGDAAEVKRCKNMEILYESLQLAHKCILNSFYGYVMRKGARWYSMEMAGIVCFTGANIITQARELIEQIGRPLELDTDGIWCVLPNTFPENFVVKTSNEKKPKVTISYPGAMLNIMVKEGFTNDQYHELVDPASVTYNIRAENSIFFEVDGPYLAMILPASKEEGKKLKKRYAVFNEDGSLAELKGFEVKRRGELQLIKIFQSSVFEAFLKGTTLEEVYASVAKVADYWLDVLYSKAANMPDAELFDLISENRSMSRKLEDYGEQKSTSISTAKRLAEFLGDQMVKDAGLSCRYVISRKPEGSPVTERAIPLAIFQAEPSVKKHFLRKWLKMPSLHDMDIRSILDWSYYIERLGSAIQKIITIPAALQQVKNPVPRVRHPDWLHKKLLEKNDIYKQKKISELFTSEGKRQIAHQPLEAGPAADIEDFGMPPRPLQPAILISTKRKRASQGDDSQVESQDLE-LTQSWREILGPPPPKGKTREEHQVWLRYHKKKWELQLKQRKERKKRRRLLDGEAQPVGGGVIRGGPITGLGSFLRRTARSILDMPWQIVQIAETSHPGLYKLWAVIGNDLHCMKLNIPRVFYVNQKVPKQE-EGATYKKVNRMLPRSNMVYYLYEYSVPEDMYQEHINEINADLSAPDIEGVYETQVPLLFRALVQLGCVCMVNK-HVVRDMAGREADAFDLEHLEMRSLAQFSYLEPGSVRHMYLYHHSQGHKALFGLFIPSQRKASIFVLDTVRSN----QMPNLSNLYTAERTALLE-KTTEELLP--PEKHTFEVRAENDMKAISRALQRILLNYKEERRGPTLIAVQSNWELRRLTAGMPVLEEFPVVPVHVVD-EISYNVLDWQRLGARRMIRHYLNLDSCLSQAFDMARYYHLPVGNLPQDVSIF-----GSDLFLARHLRKHNHLLWLSPTSRPDLGGKEADDSRLVMENDD--RGSVEINAQGCYSTACVELDLQSLAVNTILQSQHVNDMEGG-----ASLGVSFDVIQQASLEDMMSGNQGASALAS---YDETALCSNTFRILKSMVVGWVREITQYHNVYADNQVMHFYRWLRSPSSLLYDPALHRTLHNMMKKVFLQLVAEFKRLGSTVVYGNFNRIILCTKKRRIDDAIGYVEYITNSIHSKEIFHSLSISFSRCWEFLLWMDPANYGGVKGKLPSSVMYGEEGAQQKKTRQEEGDEDGSEDEDEENAEEEDGDGETDEVED--LIESNWNIMQYLPQTASCQKYFLMIVSAYIAAVYHSMKEELRRNGPGATPVKRRGNSQASQQAIGDLSALPGMISFSQEYVSSELTQNIFTITQKIQKKVTGTRSVTHTSEMF-------------PILPGSHLPLNNPALEFIKYVCQVLSLDANIVNQVNKLKRDLLRLVDVGEFSDEAQFRDPCNS-------------YILPEVICHHCNFCRDLDLCKDPSVAQDGSVLPQWF-CSNCQAQYDTNSIEMALVEALQKKLMSYTLQDLVCSKC-KGVKETSMPLY---CKCAGDFDLTFSAKSFSEQIAVFRNIASHYNMSFLEETLGWLL 2281
[Close]
BLAST of DNA polymerase epsilon catalytic subunit vs. TrEMBL
Match: A0A1S3INV5 (DNA polymerase epsilon catalytic subunit OS=Lingula unguis OX=7574 GN=LOC106165766 PE=3 SV=1)

HSP 1 Score: 2165.58 bits (5610), Expect = 0.000e+0
Identity = 1116/2354 (47.41%), Postives = 1541/2354 (65.46%), Query Frame = 3 
Query:   54 PTEKENDVFEAIERNEEKILRLKKNDQIDLVYGFDLHSAIKIRTGWLINMKTTDAIDDNKRLVSAMSYYFLEEDGSKFKSTLIFQPYFYIVTKLGCESEIQTYLMKKYSACLHNIEIIEKEDLDLDNHXXXXXXXXXXXXXHTIDDLVRVRKEIMPKIKQNQKNQESDNDYSKMLTEHFQGEKKYEYNARKSALDIMDNAIDIREYDVPYHVRVSIDTAIFIGKWYDVHGSMNIKGPNSTHITPRSDIVDHPEPIVLAYDIETTKLPLKFPDATFDQIMMISYMIDGMGYLICNREIIADDIEDFEFTPRPEFPGPFSVFNEPNEKRTIERFFDHIREVKPNIFVTYNGDFFDWPFVETRAVKHGLDMLDYIGFSKDNQNEYKSRSAIHMDCFKWVQRDSYLPIGAQGLKAVCKAKLRYNPVEVDPEEMCKVAREDPRTLANYSVSDAVATYYLYMKYVHPFIFALCTIIPMDPDEVLRKGSGTLCECLLMVEAFNSNIIFPNKQESKLNPLTNDGHVIESETYVGGHVEAIESGVFRSDIPTKFKIVPEMCKFLRKNLKETLVHVLEVEEKVTVDSVLNFDEVYNAIDEKLEDLEETNIRFECPVIYHLDVAAMYPNIILSNRLQPSALVNEKTCGACDFNVPNAKCKRPMTWKWRGEIMPATKSEYYLIQNQLEKEKFPPKKPSLPMRSFYELDKLEQATVEKERLGKFCRNAYNRKHNTRFEERTAVVCQRENAFYVDTVRAFRDRRYQYKDLTKVSKKRLDELISSENGDASEIKRANGMLVLYDSLQLAHKCILNSFYGYVMRKGARWYSMEMAGIVCSTGAAIIKYAREMIEQIGRPLELDTDGIWCILPASFPQGFEFQTNNPKKRNISFSYPGAMLNLMVQQYFTNDQYHDLVDPAKHTYRIRSENSIFFEVDGPYLAMILPASKEMNKKLKKRYAVFNRDRSLAELKGFEVKRNGELNLIKIFQSSVFESFLKGSSISEVYQHVAIVANYWLDLLYSRASTMPDEELFELISEKRCMSKKLEEYGKQKSTSISTARRLAEFLGDEMVKDAGLSFKFIISKKPEGQQVTDRAIPVAIFQAEESVKRFYLSKWLKSKDLQDFDIRNILDWDYYINRFSSNIQKIITIPAALQEVPNPVPRVAHPDWLHKILMEKDNRFKQQRITDIFQTI----TPSQAAADKM------KDIENCAPISKKKPTG-----VTSLKRARNK-DTVDVYGVQLDMDNLPNHWRDILGDPVPKGNSKSQFIVWLEFHXXXXXXXXXXXDQSELSKENINPATVKRIKTVKKGIQSGISSFFTRSKQSILEDTWQIIQITDTNVSGIYRVWVLIGQEIHNMKLTVPRTFYVNTRIPKAPGENMYFKQVHKLLPRSRIVYHLYEYNLDETIFIKHRSDILSEFIRNEVEGIYELEVPLLLRVYAKLGCMCSIDRNHFTDQQLSNNPSSFLLNELKFRSTAQHPYLSPNSIKTTFLFQQKSNRNEIIGWFDPCNNRAHLCLVEQSKPNPDKFQANVVQSWFSREREAFLSLKENESLISVVPEHVQFEVSSHKFEI-------SAFKAINKLLVAHRNEVTTPTFIATKSKMTINELYSNLPALQEYPLVPITINETDVSFNVLDWQRIAIKSALQNFVKYEKLLAEMLERARYLHIPVGNMSKFTNDYRGISDSYDLFYGRFLMKNNFIWWCNDKSEPDLGKKENQDRRMMLVDNDVLNGMIYRNKPGCYPTTCVQLEMTYFPINTIIAMHKVMEIDGTNERLFESMIVPAKTIDQAMIQSKCNAAKRNLNLTSNTMYDDVTAAGPAFKILRNVILQWLDDVRNYKNPVADEHLMGFYKWMKNSRSLFYDPALFKSLQKLMRMVFFKLIEQLNNLGVEVIYGTLNKIVLCTKRTDLMDALVHVEYATKTVRNQDIFSQLDFQYVSGWDYLIWQDVSNYSGIKS--DLESVTKEEHNSMVLEELSFVNMTNPSLS----MGLSQSQNEDSFLTTEIADSSQIEMNWHLSRYLSPMSGVQLRLIEILQYFMLTNWKIVKDEYKL----NRLAAKNDVAEEAVNTGTILGS-DASLYPSSVQRMEDFLQNEMGYKLYLLVSQL-KDVPRMHNAVPLTTXXXXXXXXXXXSNKTPPLLPLKNKVSLHPIVDLIKTTCHILALDTSARYYVNDWKRNMFKLINFDAYSDQAKWRSPYSSDQSMGDAFRSDLIITVPEVICDNCNVTRDLDLCRD--LYQVRIKNSWWFVCPTCDFPYDRNVIQETLIDQVRCICESNVMQDLKCTKCTNGILETSLAGTENCVKCGNAIQVTQNAASLKEKIKIYADIGKHYDLPYLHMMTSWMLQ 7004
            P+ KE D     +  ++++ R   N+++D+ +G+D H     + GWLINM   D +D++K+LVSA+ YYF+++DG +FK +L F+PYFY+ TK  CE E+ ++LMKKY+  +  +E + KEDLDL NHL+GLK+ +LKL F +++DL++V+K+I P +K+N+   +S + YS+MLT H  G+      ++K A D M+N IDIRE+DVPYHVRVSID  I IG WY V G    +G     I  R D+V+ P+P+VLAYDIETTKLPLKFPD++ DQIMMISYMIDG GYLICNREI+A D+EDFE+TPRPEF GPF VFNEP+E  TI++F DHI EVKPNIFVTYNGD FDWPFVE RA  H +D+   IGF+KD+  EYKSR  IHMDCF+WV+RDSYLP+G+Q LKAV KAKLRY+PVE+DPEEMC++A E P+ LANYSVSDAVATYYLYMKYVHPFIFALCTIIPM+PDEVLRKGSGTLCE LLMV+A+++NI+FPNKQE   N L++DGHV+++ETYVGGHVEA+ESGVFR+DIP +F++VPE  + L   +++T+ H +E EE + +D+V NFDEV   I EKL  L +   R E P+IYHLDV AMYPNIIL+NRLQPSA V+E TC ACDFN P A C+R MTW WRGE+MPA++SEY+ IQ QLE EKFPP  P    R+F+EL + EQA+ EK+RL  +CR AY + H TR EER A VCQREN+FYVDTVRAFRDRRY++K LTKV K ++ E  + +  D +EIKRANG+LVLYDSLQLAHKCILNSFYGYVMRKGARWY MEMAGIVC TGA II  ARE+IEQIGRPLELDTDGIWCILPASFP+ +  +T NPKK  ++ SY GAMLN+MV+  +TN QYH+LVDP    Y +R+ENSIFFEVDGPYL+MILPASKE  KKLKKRYAVFN D SLAELKGFEVKR GEL LIKIFQSSVFE+FLKGS+  E Y  VA VA+YWLD+LYS+A+ MPD ELFELISE R MS+KL +YG QKSTSISTA+RLAEFLGD+MVKDAGL+ KF+ISKKPEG  VT+RAIP+AIFQAE  VK+ YL KWLKS  + DFDIR ILDW+YYI R  S +QKIITIPAALQ V NPVPRV HPDWLHK L+EK++ +KQ+RI +IF  +     P +++   M       DIE+    S KK  G     VT+  R R + D     GV  +  +L   WR++LG P P G +K +   WLEFHKKKW+ Q+  + Q +  +             ++ G  +G+  FF ++ +++ +  WQI+QI +T   G++R+W LIG ++H +KLTVPR FYVN +  K  GE   +++V++ LPRS  V++LYEYN+ E ++++H ++I ++    ++EG+YE  VPL  R   KLGC+ ++++  F        P +F +  L FR+ AQ PYL P S+K  +L+        I G F P + +  + +V+  + N    Q   + + F+ ER        N+   S + E +    + H F++          +AI +LL A+++E    T IA +S      L S +P L ++P+VP+   ++   ++VLDWQR+  +  +Q+++  E +L  M+E+ RY HIP+GNM K    +       DLF+ R L K+N + WC+    PDLG KE  D R++    +  +  I  N  G Y T C++L++    +NTI+    V + +G +   F++   P  +++  M+Q +  A       T    YD+       F+IL++++  W+ DV +Y N  AD  ++ FY+W++++ +L YDPAL ++L  +M+ +F +LI +   LG  ++Y + N+++L TK+  + DA+ +VEY T ++R ++++  +D QY   W++L+W D +NY G+K   D+ S+T+EE      E+           S     G  + ++E+    ++  D   IEMNW++  YL   +  Q     I+  ++L  +K V++E +     N    +   ++    T   + S D +  P+ V+  ++ ++ ++  +++ +  ++ K +    N +     +              P+LP  +    +P ++ +K  C +L LD++    V   KR++ KLI    +S+ A+WR P              L  T+PEVIC  CN  RDLDLCRD  L Q     S W  CP C+  YD + I++ L+D V+      V+QDLKC KC +G+ E+++  ++ C  C      T +   L +K++ + +I  HY++  L  +  W+L+
Sbjct:   13 PSGKE-DGGNREDSTDKRLRRALFNEEVDIRFGYDRHKDTYEKVGWLINMHPGDVLDEDKKLVSAVDYYFVQDDGGRFKVSLPFKPYFYVATKANCEREVASFLMKKYAGKMAAVETVNKEDLDLHNHLVGLKRTYLKLSFSSVEDLMKVKKDINPAVKKNKDRAKSQDAYSEMLTSHLAGDTGSSVMSKKIA-DQMENIIDIREHDVPYHVRVSIDKRIHIGHWYAVRG----RGAGPPEIRRREDLVETPDPVVLAYDIETTKLPLKFPDSSTDQIMMISYMIDGQGYLICNREIVAQDVEDFEYTPRPEFEGPFIVFNEPDEMGTIQKFIDHIIEVKPNIFVTYNGDSFDWPFVEARAAFHSIDLEREIGFAKDSMGEYKSRPCIHMDCFRWVKRDSYLPVGSQNLKAVAKAKLRYDPVELDPEEMCRMANEQPQVLANYSVSDAVATYYLYMKYVHPFIFALCTIIPMEPDEVLRKGSGTLCEALLMVQAYHANIVFPNKQEQVFNKLSDDGHVLDTETYVGGHVEALESGVFRADIPCRFRMVPEAFQGLIDKVEKTMKHAIEEEEGIPLDTVTNFDEVCAEIIEKLSRLRDCPNRLENPIIYHLDVGAMYPNIILTNRLQPSANVDEATCAACDFNRPGALCQRKMTWTWRGEVMPASRSEYHRIQQQLENEKFPPAFPDGKPRAFHELSREEQASFEKKRLADYCRKAYKKTHVTRIEERVATVCQRENSFYVDTVRAFRDRRYEFKGLTKVWKNKVSE--AEKKKDPAEIKRANGLLVLYDSLQLAHKCILNSFYGYVMRKGARWYCMEMAGIVCHTGANIIMQARELIEQIGRPLELDTDGIWCILPASFPENYVIKTTNPKKSKVTISYSGAMLNIMVKDSYTNPQYHELVDPKTLKYEVRAENSIFFEVDGPYLSMILPASKEEGKKLKKRYAVFNFDGSLAELKGFEVKRRGELQLIKIFQSSVFEAFLKGSTREECYACVAKVADYWLDVLYSKAANMPDSELFELISENRSMSRKLSDYGGQKSTSISTAKRLAEFLGDQMVKDAGLACKFVISKKPEGSPVTERAIPLAIFQAEPGVKKHYLKKWLKSPSMSDFDIRAILDWEYYIERLGSCVQKIITIPAALQGVANPVPRVRHPDWLHKKLLEKNDIYKQKRINEIFAPVPKPNPPEESSESPMDTSQNVGDIEDIGDKSHKKQNGVHLVSVTTNNRKRGRGDAESSQGVSQEDSDLTKSWREVLGAPPPLGKTKEEHRAWLEFHKKKWEFQRRQRQQQQKRRRLDTGFEPTGGSVIRSGPATGLGGFFRKTARAMFDLPWQIVQIAETGHPGLFRLWALIGTDLHAIKLTVPRIFYVNQKSAKE-GEGQMWRKVNRTLPRSHPVFNLYEYNVPEDVYLEHINEISADLSSPDIEGVYETHVPLSFRALVKLGCVVTVNK-EFIKLMGGREPETFDIEHLDFRTLAQFPYLEPGSMKHIYLYHHVCGHKMIFGLFFPMSKKGSVFVVDTVRSN----QMPNMTALFNAER-------NNKVTKSNMAEEL-LPAAGHTFDVRVETDVRQVHRAIQRLLSAYKDEKRGATLIAVQSPHDFQHLTSAMPGLTDFPMVPVHYLDSPELYSVLDWQRMGSRRMVQHYLNLEIVLQTMMEQCRYFHIPLGNMPKDPTMF-----GCDLFFARHLQKHNHVLWCSRSERPDLGGKEADDNRLLTEFEE--SSSIEINNSGSYSTVCIELDLASLAVNTILESQHVNDYEGASLVNFDT--TPQVSLED-MVQGQGAA-------TMLASYDETALCSATFRILKSMVQGWVRDVTHYGNVFADYQIVHFYRWLRHTGALLYDPALRRTLHNMMKKLFMQLIAEFKRLGSNIVYASFNRVILSTKKRRISDAIAYVEYITNSIRAKELYRCIDIQYKECWEFLMWLDAANYGGVKGKFDVPSLTEEEEAQSQREKERQKEKEGDEGSDDEDEGGLEKEDEEVLNLSDDDDDPVIEMNWNIVHYLPEAAACQTNFNMIVAGYILAVYKQVQEEARSMTPGNTPIRRRHTSQSQTQTNPAVKSMDGAATPAQVEFSQNLIEGDLTQQMFGITQKIQKKIAGNRNTLGDAATEF-------------PILPGSHLPLSNPALEFVKAVCKVLELDSNISLPVMKMKRDLLKLIGVGEFSNDAEWRDPC-------------LSYTLPEVICKTCNYIRDLDLCRDPLLLQEGESMSVW-QCPQCNNEYDTDEIEQALVDAVQRKSMGYVLQDLKCKKC-HGVKESNM--SKYCT-CAGDFSNTVSLEDLGKKLRTFRNIASHYNMAQLLEVVEWILK 2296
[Close]
BLAST of DNA polymerase epsilon catalytic subunit vs. TrEMBL
Match: A0A2R2MT89 (DNA polymerase epsilon catalytic subunit OS=Lingula unguis OX=7574 GN=LOC106166515 PE=3 SV=1)

HSP 1 Score: 2159.41 bits (5594), Expect = 0.000e+0
Identity = 1113/2344 (47.48%), Postives = 1536/2344 (65.53%), Query Frame = 3 
Query:   90 ERNEEKILRLKKNDQIDLVYGFDLHSAIKIRTGWLINMKTTDAIDDNKRLVSAMSYYFLEEDGSKFKSTLIFQPYFYIVTKLGCESEIQTYLMKKYSACLHNIEIIEKEDLDLDNHXXXXXXXXXXXXXHTIDDLVRVRKEIMPKIKQNQKNQESDNDYSKMLTEHFQGEKKYEYNARKSALDIMDNAIDIREYDVPYHVRVSIDTAIFIGKWYDVHGSMNIKGPNSTHITPRSDIVDHPEPIVLAYDIETTKLPLKFPDATFDQIMMISYMIDGMGYLICNREIIADDIEDFEFTPRPEFPGPFSVFNEPNEKRTIERFFDHIREVKPNIFVTYNGDFFDWPFVETRAVKHGLDMLDYIGFSKDNQNEYKSRSAIHMDCFKWVQRDSYLPIGAQGLKAVCKAKLRYNPVEVDPEEMCKVAREDPRTLANYSVSDAVATYYLYMKYVHPFIFALCTIIPMDPDEVLRKGSGTLCECLLMVEAFNSNIIFPNKQESKLNPLTNDGHVIESETYVGGHVEAIESGVFRSDIPTKFKIVPEMCKFLRKNLKETLVHVLEVEEKVTVDSVLNFDEVYNAIDEKLEDLEETNIRFECPVIYHLDVAAMYPNIILSNRLQPSALVNEKTCGACDFNVPNAKCKRPMTWKWRGEIMPATKSEYYLIQNQLEKEKFPPKKPSLPMRSFYELDKLEQATVEKERLGKFCRNAYNRKHNTRFEERTAVVCQRENAFYVDTVRAFRDRRYQYKDLTKVSKKRLDELISSENGDASEIKRANGMLVLYDSLQLAHKCILNSFYGYVMRKGARWYSMEMAGIVCSTGAAIIKYAREMIEQIGRPLELDTDGIWCILPASFPQGFEFQTNNPKKRNISFSYPGAMLNLMVQQYFTNDQYHDLVDPAKHTYRIRSENSIFFEVDGPYLAMILPASKEMNKKLKKRYAVFNRDRSLAELKGFEVKRNGELNLIKIFQSSVFESFLKGSSISEVYQHVAIVANYWLDLLYSRASTMPDEELFELISEKRCMSKKLEEYGKQKSTSISTARRLAEFLGDEMVKDAGLSFKFIISKKPEGQQVTDRAIPVAIFQAEESVKRFYLSKWLKSKDLQDFDIRNILDWDYYINRFSSNIQKIITIPAALQEVPNPVPRVAHPDWLHKILMEKDNRFKQQRITDIFQTI----TPSQAAADKM------KDIENCAPISKKKPTGV-------TSLKRARNKDTVDVYGVQLDMDNLPNHWRDILGDPVPKGNSKSQFIVWLEFHXXXXXXXXXXXDQSELSKENINPATVKRIKTVKKGIQSGISSFFTRSKQSILEDTWQIIQITDTNVSGIYRVWVLIGQEIHNMKLTVPRTFYVNTRIPKAPGENMYFKQVHKLLPRSRIVYHLYEYNLDETIFIKHRSDILSEFIRNEVEGIYELEVPLLLRVYAKLGCMCSIDRNHFTDQQLSNNPSSFLLNELKFRSTAQHPYLSPNSIKTTFLFQQKSNRNEIIGWFDPCNNRAHLCLVEQSKPNPDKFQANVVQSWFSREREAFLSLKENESLISVVPEHVQFEVSSHKFEI-------SAFKAINKLLVAHRNEVTTPTFIATKSKMTINELYSNLPALQEYPLVPITINETDVSFNVLDWQRIAIKSALQNFVKYEKLLAEMLERARYLHIPVGNMSKFTNDYRGISDSYDLFYGRFLMKNNFIWWCNDKSEPDLGKKENQDRRMMLVDNDVLNGMIYRNKPGCYPTTCVQLEMTYFPINTIIAMHKVMEIDGTNERLFESMIVPAKTIDQAMIQSKCNAAKRNLNLTSNTMYDDVTAAGPAFKILRNVILQWLDDVRNYKNPVADEHLMGFYKWMKNSRSLFYDPALFKSLQKLMRMVFFKLIEQLNNLGVEVIYGTLNKIVLCTKRTDLMDALVHVEYATKTVRNQDIFSQLDFQYVSGWDYLIWQDVSNYSGIKS--DLESVTKEEHNSMV-----LEELSFVNMTNPSLSMGLSQSQNEDSFLTTEIADSSQIEMNWHLSRYLSPMSGVQLRLIEILQYFMLTNWKIVKDEYKL----NRLAAKNDVAEEAVNTGTILGS-DASLYPSSVQRMEDFLQNEMGYKLYLLVSQL-KDVPRMHNAVPLTTXXXXXXXXXXXSNKTPPLLPLKNKVSLHPIVDLIKTTCHILALDTSARYYVNDWKRNMFKLINFDAYSDQAKWRSPYSSDQSMGDAFRSDLIITVPEVICDNCNVTRDLDLCRD--LYQVRIKNSWWFVCPTCDFPYDRNVIQETLIDQVRCICESNVMQDLKCTKCTNGILETSLAGTENCVKCGNAIQVTQNAASLKEKIKIYADIGKHYDLPYLHMMTSWMLQ 7004
            +  ++++ R + N+++D+ +G+D H     + GWLINM   D +D++K+LVSA+ YYF+++DG +FK +L F+PYFY+ TK  CE E+ ++LMKKY+  +  +E + KEDLDL NHL+GLK+ +LKL F +++DL++V+K+I P +K+N+   +S + YS+MLT H  G+      ++K A D M+N IDIRE+DVPYHVRVSID  I IG WY V G    +G     I  R D+V+ P+P+VLAYDIETTKLPLKFPD++ DQIMMISYMIDG GYLICNREI+A D+EDFE+TPRPEF GPF VFNEP+E  TI++F DHI EVKPNIFVTYNGD FDWPFVE RA  H +D+   IGF+KD+  EYKSR  IHMDCF+WV+RDSYLP+G+Q LKAV KAKLRY+PVE+DPEEMC++A E P+ LANYSVSDAVATYYLYMKYVHPFIFALCTIIPM+PDEVLRKGSGTLCE LLMV+A+++NI+FPNKQE   N L++DGHV+++ETYVGGHVEA+ESGVFR+DIP +F++VPE  + L   +++T+ H +E EE + +D+V NFDEV + I EKL  L +   R E P+IYHLDV AMYPNIIL+NRLQPSA V+E TC ACDFN P A C+R MTW WRGE+MPA++SEY+ IQ QLE EKFPP  P    R+F+EL + EQA+ EK+RL  +CR AY + H TR EER A VCQREN+FYVDTVRAFRDRRY++K LTKV K ++ E  + +  D +EIKRANG+LVLYDSLQLAHKCILNSFYGYVMRKGARWY MEMAGIVC TGA II  ARE+IEQIGRPLELDTDGIWCILPASFP+ +  +T NPKK  ++ SY GAMLN+MV+  +TN QYH+LVDP    Y +R+ENSIFFEVDGPYL+MILPASKE  KKLKKRYAVFN D SLAELKGFEVKR GEL LIKIFQSSVFE+FLKGS+  E Y  VA VA+YWLD+LYS+A+ MPD ELFELISE R MS+KL +YG QKSTSISTA+RLAEFLGD+MVKDAGL+ KF+ISKKPEG  VT+RAIP+AIFQAE  VK+ YL KWLKS  + DFDIR ILDW+YYI R  S +QKIITIPAALQ V NPVPRV HPDWLHK L+EK++ +KQ+RI +IF  +     P +++   M       DIE+    S KK  G+        + KR R        G Q D D L   W ++LG P P G +K +   WLEFHKKKW+ Q+  + Q +  +             ++ G  +G+  FF ++ +++ +  WQI+QI +T   G++R+W LIG ++H +KLTVPR FYVN +  K  GE   +++V++ LPRS  V++LYEYN+ E ++++H ++I ++    ++EG+YE  VPL  R   KLGC+ ++++  F        P +F +  L FR+ AQ PYL P S+K  +L+        I G F P + +  + +V+  + N    Q   + + F+ ER        N+   S + E +    + H F++          +AI +LL A+++E    T IA +S      L S +P L ++P+VP+   ++   ++VLDWQR+  +  +Q+++  E +L  M+E+ RY HIP+GNM K    +       DLF+ R L K+N + WC+    PDLG KE  D R++    +  +  I  N  G Y T C++L++    +NTI+    V + +G +   F++   P  +++  M+Q +  A       T    YD+       F+IL++++  W+ DV +Y N  AD  ++ FY+W++++ +L YDPAL ++L  +M+ +F +LI +   LG  ++Y + N+++L TK+  + DA+ +VEY T ++R ++++  +D QY   W++L+W D +NY G+K   D+ S+T+EE          L+E      ++     GL +   E   L+ +  D   IEMNW++  YL   +  Q     I+  ++L  +K V++E +     N    +   ++    T   + S D +  P+ V+  ++ ++ ++  +++ +  ++ K +    N +     +              P+LP  +    +P ++ +K  C +L LD++    V   KR++ KLI    +S+ A+WR P              L  T+PEVIC  CN  RDLDLCRD  L Q     S W  CP C+  YD + I++ L+D V+      V+QDLKC KC +G+ E+++  ++ C  C      T +   L +K++ + +I  HY++  L  +  W+L+
Sbjct:    2 DSTDKRLRRAQFNEEVDIRFGYDRHKDTYEKVGWLINMHPGDVLDEDKKLVSAVDYYFVQDDGGRFKVSLPFKPYFYVATKANCEREVASFLMKKYAGKMVAVETVNKEDLDLHNHLVGLKRTYLKLSFSSVEDLMKVKKDINPAVKKNKDRAKSQDAYSEMLTSHLAGDTGSSVMSKKIA-DQMENIIDIREHDVPYHVRVSIDKRIHIGHWYAVRG----RGAGPPEIRRREDLVETPDPVVLAYDIETTKLPLKFPDSSTDQIMMISYMIDGQGYLICNREIVAQDVEDFEYTPRPEFEGPFIVFNEPDEMGTIQKFIDHIIEVKPNIFVTYNGDSFDWPFVEARAAFHSIDLEREIGFAKDSMGEYKSRPCIHMDCFRWVKRDSYLPVGSQNLKAVAKAKLRYDPVELDPEEMCRMANEQPQVLANYSVSDAVATYYLYMKYVHPFIFALCTIIPMEPDEVLRKGSGTLCEALLMVQAYHANIVFPNKQEQVFNKLSDDGHVLDTETYVGGHVEALESGVFRADIPCRFRMVPEAFQGLIDKVEKTMKHAIEEEEGIPLDTVTNFDEVCSEIIEKLSRLRDCPNRLENPIIYHLDVGAMYPNIILTNRLQPSANVDEATCAACDFNRPGALCQRKMTWTWRGEVMPASRSEYHRIQQQLENEKFPPAFPDGKPRAFHELSREEQASFEKKRLADYCRKAYKKTHVTRIEERVATVCQRENSFYVDTVRAFRDRRYEFKGLTKVWKNKVAE--AEKKKDPAEIKRANGLLVLYDSLQLAHKCILNSFYGYVMRKGARWYCMEMAGIVCHTGANIIMQARELIEQIGRPLELDTDGIWCILPASFPENYVVKTTNPKKSKVTISYSGAMLNIMVKDSYTNPQYHELVDPKTLKYEVRAENSIFFEVDGPYLSMILPASKEEGKKLKKRYAVFNFDGSLAELKGFEVKRRGELQLIKIFQSSVFEAFLKGSTREECYACVAKVADYWLDVLYSKAANMPDSELFELISENRSMSRKLSDYGGQKSTSISTAKRLAEFLGDQMVKDAGLACKFVISKKPEGSPVTERAIPLAIFQAEPGVKKHYLKKWLKSPSMSDFDIRAILDWEYYIERLGSCVQKIITIPAALQGVANPVPRVRHPDWLHKKLLEKNDIYKQKRINEIFAPVPKPNPPEESSESPMDTSQNVGDIEDIGDKSHKKQNGLHLVSVTTNNRKRGRGDAESSQGGSQEDSD-LTKSWGEVLGAPPPLGKTKEEHRAWLEFHKKKWEFQRRQRQQQQKRRRLDTGFEPTGGSVIRSGPATGLGGFFRKTARAMFDLPWQIVQIAETGHPGLFRLWALIGTDLHAIKLTVPRIFYVNQKSAKE-GEGQMWRKVNRTLPRSHPVFNLYEYNVPEDVYLEHINEISADLSSPDIEGVYETHVPLGFRALVKLGCVVTVNKE-FIKLMGGREPETFDIEHLDFRTLAQFPYLEPGSMKHIYLYHHVCGHKMIFGLFFPMSKKGSVFVVDTVRSN----QMPNMTALFNAER-------NNKVTKSNMAEEL-LPAAGHTFDVRVETDVRQVHRAIQRLLSAYKDEKRGATLIAVQSPHDFQHLTSAMPGLTDFPMVPVHYLDSPELYSVLDWQRMGSRRMVQHYLNLEIVLQTMMEQCRYFHIPLGNMPKDPTMF-----GCDLFFARHLQKHNHVLWCSRSERPDLGGKEADDNRLLTEFEE--SSSIEINNSGSYSTVCIELDLASLAVNTILESQHVNDYEGASLVNFDT--TPQVSLED-MVQGQGAA-------TMLASYDETALCSATFRILKSMVQGWVRDVTHYGNVFADYQIVHFYRWLRHTGALLYDPALRRTLHNMMKKLFMQLIAEFKRLGSNIVYASFNRVILSTKKRRISDAIAYVEYITNSIRAKELYRCIDIQYKECWEFLMWLDAANYGGVKGKFDVPSLTEEEEAQSQREKERLKEKEGDEGSDDEDDGGLEKEDEEVLNLSDDDDDDPVIEMNWNIVHYLPEAAACQTNFNMIVAGYILAVYKQVQEEARSMTPGNTPIRRRHTSQSQTQTNPAVKSMDGAATPAQVEFSQNLIEGDLTQQMFGITQKIQKKIAGNRNTLGDAATEF-------------PILPGSHLPLSNPALEFVKAVCKVLELDSNISLPVMKMKRDLLKLIGVGEFSNDAEWRDPC-------------LSYTLPEVICKTCNYIRDLDLCRDPLLLQEGESMSVW-QCPQCNNEYDTDEIEQALVDAVQRKSMGYVLQDLKCKKC-HGVKESNM--SKYCT-CAGDFSNTVSLEDLGQKLRTFRNIASHYNMAQLLEVVEWILK 2275
[Close]
BLAST of DNA polymerase epsilon catalytic subunit vs. TrEMBL
Match: I3K7B0 (DNA polymerase epsilon catalytic subunit OS=Oreochromis niloticus OX=8128 GN=pole PE=3 SV=1)

HSP 1 Score: 2158.64 bits (5592), Expect = 0.000e+0
Identity = 1098/2320 (47.33%), Postives = 1536/2320 (66.21%), Query Frame = 3 
Query:  102 EKILRLKKNDQIDLVYGFDLHSAIKIRTGWLINMKTTDAIDDNKRLVSAMSYYFLEEDGSKFKSTLIFQPYFYIVTKLGCESEIQTYLMKKYSACLHNIEIIEKEDLDLDNHXXXXXXXXXXXXXHTIDDLVRVRKEIMPKIKQNQKNQESDNDYSKMLTEHFQGEKKY---EYNARKSALDIMDNAIDIREYDVPYHVRVSIDTAIFIGKWYDVHGSMNIKGPNSTHITPRSDIVDHPEPIVLAYDIETTKLPLKFPDATFDQIMMISYMIDGMGYLICNREIIADDIEDFEFTPRPEFPGPFSVFNEPNEKRTIERFFDHIREVKPNIFVTYNGDFFDWPFVETRAVKHGLDMLDYIGFSKDNQNEYKSRSAIHMDCFKWVQRDSYLPIGAQGLKAVCKAKLRYNPVEVDPEEMCKVAREDPRTLANYSVSDAVATYYLYMKYVHPFIFALCTIIPMDPDEVLRKGSGTLCECLLMVEAFNSNIIFPNKQESKLNPLTNDGHVIESETYVGGHVEAIESGVFRSDIPTKFKIVPEMCKFLRKNLKETLVHVLEVEEKVTVDSVLNFDEVYNAIDEKLEDLEETNIRFECPVIYHLDVAAMYPNIILSNRLQPSALVNEKTCGACDFNVPNAKCKRPMTWKWRGEIMPATKSEYYLIQNQLEKEKFPPKKPSLPMRSFYELDKLEQATVEKERLGK--FCRNAYNRKHNTRFEERTAVVCQRENAFYVDTVRAFRDRRYQYKDLTKVSKKRLDELISSENGDASEIKRANGMLVLYDSLQLAHKCILNSFYGYVMRKGARWYSMEMAGIVCSTGAAIIKYAREMIEQIGRPLELDTDGIWCILPASFPQGFEFQTNNPKKRNISFSYPGAMLNLMVQQYFTNDQYHDLVDPAKHTYRIRSENSIFFEVDGPYLAMILPASKEMNKKLKKRYAVFNRDRSLAELKGFEVKRNGELNLIKIFQSSVFESFLKGSSISEVYQHVAIVANYWLDLLYSRASTMPDEELFELISEKRCMSKKLEEYGKQKSTSISTARRLAEFLGDEMVKDAGLSFKFIISKKPEGQQVTDRAIPVAIFQAEESVKRFYLSKWLKSKDLQDFDIRNILDWDYYINRFSSNIQKIITIPAALQEVPNPVPRVAHPDWLHKILMEKDNRFKQQRITDIF------QTITPSQAA-----ADKMKDIENCA-PISKKKPTGVTSLKRARNKDTVDVYGVQLDMDNLPNHWRDILGDPVPKGNSKSQFIVWLEFHXXXXXXXXXXXDQSELSKENIN-PATVKRIKTVKKGIQSGISSFFTRSKQSILEDTWQIIQITDTNVSGIYRVWVLIGQEIHNMKLTVPRTFYVNTRIPKAPGENMYFKQVHKLLPRSRIVYHLYEYNLDETIFIKHRSDILSEFIRNEVEGIYELEVPLLLRVYAKLGCMCSIDRNHFTDQQLSNNPSSFLLNELKFRSTAQHPYLSPNSIKTTFLFQQKSNRNEIIGWFDPCNNRAHLCLVEQSKPNPDKFQANVVQSWFSREREAFLSLKENESLISVVPEHVQFEVSSHKFEISAFKAINKLLVAHRNEVTTPTFIATKSKMTINELYSNLPALQEYPLVPITINETDVSFNVLDWQRIAIKSALQNFVKYEKLLAEMLERARYLHIPVGNMSKFTNDYRGISDSYDLFYGRFLMKNNFIWWCNDKSEPDLGKKENQDRRMMLVDNDVLNGMIYRNKPGCYPTTCVQLEMTYFPINTIIAMHKVMEIDGTNERLFESMIVPAKTIDQAMIQSKCNAAKRNLNLTSNTMYDDVTAAGPAFKILRNVILQWLDDVRNYKNPVADEHLMGFYKWMKNSRSLFYDPALFKSLQKLMRMVFFKLIEQLNNLGVEVIYGTLNKIVLCTKRTDLMDALVHVEYATKTVRNQDIFSQLDFQYVSGWDYLIWQDVSNYSGIKSDLESVTKEEHNSMVLEELSFVNMTNPSLSMGLSQSQNEDSFLTTEIADSSQIEMNWHLSRYLSPMSGVQLRLIEILQYFMLTNWKIVKDEYKLNRLAAKNDVAEEAVNTGTILGSDASLYPSSVQRMEDFLQNEMGYKLYLLVSQLKDVPRMHNAVPLTTXXXXXXXXXXXSNKTPPLLPLKNKVSLHPIVDLIKTTCHILALDTSARYYVNDWKRNMFKLINFDAYSDQAKWRSPYSSDQSMGDAFRSDLIITVPEVICDNCNVTRDLDLCRD--LYQVRIKNSWWFVCPTCDFPYDRNVIQETLIDQVRCICESNVMQDLKCTKCTNGILETSLAGTENCVKCGNAIQVTQNAASLKEKIKIYADIGKHYDLPYLHMMTSWML 7001
            +++ R +  D++D  +GFD       +TGWLINM   + +D++KR++SA+ YYF++EDGS+FK +L F+PYFYI TK  CE E+ +YL KK+   +  +EI+ KEDLDL NHL+GLK+ ++KL F+T+DDLV+V++EI P +++N++ ++S++ Y+ ML+    G       E    KS  D +DN +D+REYDVPYHVRVSID  I +  WY+V    +   P    I  R D+V+ P+P+VLA+DIETTKLPLKFPDA  DQIMMISYMIDG G+LI NREI++++IEDFEFTP+PE+ GPF+VFNE NE   I+R+FDH++E KPNIFVTYNGDFFDWPF+E RA  HGL M   IGF KDNQ EYK+  AIHMDC +WV+RDSYLP+G+  LKA  KAKL Y+PVE+DPEEMC++A E+P+TLA YSVSDAVATYYLYMKYVHPFIFALCTIIPM+PDEVLRKGSGTLCE LLMV+AF++NIIFPNKQE   N LT+DGHV++SETYVGGHVEA+ESGVFRSDIP +FK+ P    FL + ++ T+ H +E EEK+ ++ V NF+EV + I +KL  L+E   R ECP+IYHLDV AMYPNIIL+NRLQPSA+V+E TC ACDFN P A C+R MTW+WRGEIMPA++SE++ IQ QLE EKFPP  P+ P R+F+ L + EQA  EK+RL +  +C+ AY + H T+ EER   +CQREN+FYVDTVRAFRDRRY++K L KV KK+L    + ++GDA+E+KR   M +LY+SLQLAHKCILNSFYGYVMRKGARWYSMEMAGIVC TGA II  ARE+IEQIGRPLELDTDGIWC+LP +FP+ F  +T+N KK  ++ SYPGAMLN+MV++ FTNDQYH+LVDPA  TY IR+ENSIFFEVDGPYLAMILPASKE  KKLKKRYAVFN D SLAELKGFEVKR GEL LIKIFQSSVFE+FLKG+++ EVY  VA VA+YWLD+LYS+A+ MPD ELF+LISE R MS+KLE+YG+QKSTSISTA+RLAEFLGD+MVKDAGLS +++IS+KPEG  VT+RAIP+AIFQAE SVK+ +L KWLK   L D DIR+ILDW YYI R  S IQKIITIPAALQ+V NPVPRV HPDWLHK L+EK++ +KQ++I+++F      Q    SQ A     A    DIE+   P    +P  + S KR R     D      D++ L   WR+ILG P PKG ++ +  VWL +HKKKW++Q   + + +  +  ++  A       ++ G  +G+ SF  R+ +SIL+  WQI+QI +T+  G+Y++W +IG ++H MKL +PR FYVN ++PK   E   +K+V+++LPRS +VY+LYEY++ E ++ +H ++I ++    ++EG+YE +VPLL R   +LGC+C +++ H           +F L  L+ RS AQ  YL P S++  +L+        + G F P   +A + +++  + N    Q   + + ++ ER A L  K  E L+   PE   FEV +     +  +A+ ++L+ ++ E   PT IA +S   +  L + +P L+E+P+VP+ + + ++S+NVLDWQR+  +  +++++  +  L++  + ARY H+PVGN+ +  + +       DLF  R L K+N + W +  S PDLG KE  D R+++ ++D   G +  N  GCY T CV+L++    +NTI+    V +++G       S+ V    I QA ++   +    N   ++   YD+       F+IL+++++ W+ ++  Y N  AD  +M FY+W+++  SL YDPAL ++L  +M+ VF +L+ +   LG  V+YG  N+I+LCTK+  + DA+ +VEY T ++ +++IF  L   +   W++L+W D +NY G+K  L S   E        +       +       ++ ++ D   T E+ D   IE NW++ +YL   +  Q   + I+  ++   +  +K+E + N   A                 D S  P  +   ++++ +E+   ++ +  +++       +V  T++               P+LP  +    +P ++ IK  C +L+LD +    VN  KR++ +L++   +SD+A++R P +S               +PEVIC +CN  RDLDLC+D  + Q       WF C  C   YD N I+  L++ ++    S  +QDL C+KC  G+ ETS+       KC     +T +A S  E+I ++ +I  HY++ +L     W+L
Sbjct:   32 KRLERSQFTDEMDARFGFDRMKEPGEKTGWLINMHPAEILDEDKRMISAVDYYFIQEDGSRFKVSLPFKPYFYIATKKNCEREVISYLSKKFQGKVAKLEILPKEDLDLPNHLVGLKRNYIKLAFNTVDDLVKVKREIAPAVRKNREREQSNDAYTSMLSSALSGGNVTSVDEDGMSKSISDQLDNIVDMREYDVPYHVRVSIDLKIHVAHWYNVRYRGSAYPPE---IVRRDDLVERPDPVVLAFDIETTKLPLKFPDAETDQIMMISYMIDGQGFLITNREIVSENIEDFEFTPKPEYEGPFTVFNEDNEAALIQRWFDHVQETKPNIFVTYNGDFFDWPFIEVRAALHGLSMHREIGFQKDNQGEYKASQAIHMDCLRWVKRDSYLPVGSHNLKAAAKAKLGYDPVELDPEEMCRMATEEPQTLATYSVSDAVATYYLYMKYVHPFIFALCTIIPMEPDEVLRKGSGTLCEALLMVQAFHANIIFPNKQEQIFNKLTDDGHVLDSETYVGGHVEALESGVFRSDIPCRFKMNPAAFDFLLQRVERTMRHAVEEEEKIPLEQVTNFNEVCDEIKKKLTSLKEVPNRIECPLIYHLDVGAMYPNIILTNRLQPSAMVDEATCAACDFNKPGATCQRRMTWQWRGEIMPASRSEFHRIQQQLESEKFPPLFPNGPPRAFHTLTREEQAKHEKKRLAESDYCKKAYKKTHVTKLEERVTTICQRENSFYVDTVRAFRDRRYEFKGLHKVWKKKLSS--AQDSGDAAEVKRCKNMEILYESLQLAHKCILNSFYGYVMRKGARWYSMEMAGIVCFTGANIITQARELIEQIGRPLELDTDGIWCVLPNTFPENFVVKTSNEKKPKVTISYPGAMLNIMVKEGFTNDQYHELVDPASVTYNIRAENSIFFEVDGPYLAMILPASKEEGKKLKKRYAVFNEDGSLAELKGFEVKRRGELQLIKIFQSSVFEAFLKGTTLEEVYASVAKVADYWLDVLYSKAANMPDAELFDLISENRSMSRKLEDYGEQKSTSISTAKRLAEFLGDQMVKDAGLSCRYVISRKPEGSPVTERAIPLAIFQAEPSVKKHFLRKWLKMPSLHDMDIRSILDWSYYIERLGSAIQKIITIPAALQQVKNPVPRVRHPDWLHKKLLEKNDIYKQKKISELFTSEGKRQVRLTSQIAHQPLEAGPAADIEDFGMPPRPLQPAILISTKRKRASQGDDSQVESQDLE-LTQSWREILGPPPPKGKTREEHQVWLRYHKKKWELQLKQRKERKKRRRLLDGEAQPVGGGVIRGGPITGLGSFLRRTARSILDMPWQIVQIAETSHPGLYKLWAVIGNDLHCMKLNIPRVFYVNQKVPKQE-EGATYKKVNRMLPRSNMVYYLYEYSVPEDMYQEHINEINADLSAPDIEGVYETQVPLLFRALVQLGCVCMVNK-HVVRDMAGREADAFDLEHLEMRSLAQFSYLEPGSVRHMYLYHHSQGHKALFGLFIPSQRKASIFVLDTVRSN----QMPNLSNLYTAERTALLE-KTTEELLP--PEKHTFEVRAENDMKAISRALQRILLNYKEERRGPTLIAVQSNWELRRLTAGMPVLEEFPVVPVHVVD-EISYNVLDWQRLGARRMIRHYLNLDSCLSQAFDMARYYHLPVGNLPQDVSIF-----GSDLFLARHLRKHNHLLWLSPTSRPDLGGKEADDSRLVMENDD--RGSVEINAQGCYSTACVELDLQSLAVNTILQSQHVNDMEGG-----ASLGVSFDVIQQASLEDMMSG---NQGASALASYDETALCSNTFRILKSMVVGWVREITQYHNVYADNQVMHFYRWLRSPSSLLYDPALHRTLHNMMKKVFLQLVAEFKRLGSTVVYGNFNRIILCTKKRRIDDAIGYVEYITNSIHSKEIFHSLSISFSRCWEFLLWMDPANYGGVKGKLPSSVMEGAQQKKTRQEEGDEDGSEDEDEENAEEEDGDG-ETDEVED--LIESNWNIMQYLPQTASCQKYFLMIVSAYIAAVYHSMKEELRRNGPGATPVKRRGNSQASQQAIGDLSALPGMISFSQEYVSSELTQNIFTITQKIQKKVTGTRSVTHTSEMF-------------PILPGSHLPLNNPALEFIKYVCQVLSLDANIVNQVNKLKRDLLRLVDVGEFSDEAQFRDPCNS-------------YILPEVICHHCNFCRDLDLCKDPSVAQDGSVLPQWF-CSNCQAQYDTNSIEMALVEALQKKLMSYTLQDLVCSKC-KGVKETSMPLY---CKCAGDFDLTFSAKSFSEQIAVFRNIASHYNMSFLEETLGWLL 2286
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BLAST of DNA polymerase epsilon catalytic subunit vs. Ensembl Cavefish
Match: pole (polymerase (DNA directed), epsilon [Source:ZFIN;Acc:ZDB-GENE-070705-557])

HSP 1 Score: 2038.08 bits (5279), Expect = 0.000e+0
Identity = 998/1929 (51.74%), Postives = 1358/1929 (70.40%), Query Frame = 3 
Query:  102 EKILRLKKNDQIDLVYGFDLHSAIKIRTGWLINMKTTDAIDDNKRLVSAMSYYFLEEDGSKFKSTLIFQPYFYIVTKLGCESEIQTYLMKKYSACLHNIEIIEKEDLDLDNHXXXXXXXXXXXXXHTIDDLVRVRKEIMPKIKQNQKNQESDNDYSKMLTEHFQGEKKY---EYNARKSALDIMDNAIDIREYDVPYHVRVSIDTAIFIGKWYDVHGSMNIKGPNSTHITPRSDIVDHPEPIVLAYDIETTKLPLKFPDATFDQIMMISYMIDGMGYLICNREIIADDIEDFEFTPRPEFPGPFSVFNEPNEKRTIERFFDHIREVKPNIFVTYNGDFFDWPFVETRAVKHGLDMLDYIGFSKDNQNEYKSRSAIHMDCFKWVQRDSYLPIGAQGLKAVCKAKLRYNPVEVDPEEMCKVAREDPRTLANYSVSDAVATYYLYMKYVHPFIFALCTIIPMDPDEVLRKGSGTLCECLLMVEAFNSNIIFPNKQESKLNPLTNDGHVIESETYVGGHVEAIESGVFRSDIPTKFKIVPEMCKFLRKNLKETLVHVLEVEEKVTVDSVLNFDEVYNAIDEKLEDLEETNIRFECPVIYHLDVAAMYPNIILSNRLQPSALVNEKTCGACDFNVPNAKCKRPMTWKWRGEIMPATKSEYYLIQNQLEKEKFPPKKPSLPMRSFYELDKLEQATVEKERLGKFCRNAYNRKHNTRFEERTAVVCQRENAFYVDTVRAFRDRRYQYKDLTKVSKKRLDELISSENGDASEIKRANGMLVLYDSLQLAHKCILNSFYGYVMRKGARWYSMEMAGIVCSTGAAIIKYAREMIEQIGRPLELDTDGIWCILPASFPQGFEFQTNNPKKRNISFSYPGAMLNLMVQQYFTNDQYHDLVDPAKHTYRIRSENSIFFEVDGPYLAMILPASKEMNKKLKKRYAVFNRDRSLAELKGFEVKRNGELNLIKIFQSSVFESFLKGSSISEVYQHVAIVANYWLDLLYSRASTMPDEELFELISEKRCMSKKLEEYGKQKSTSISTARRLAEFLGDEMVKDAGLSFKFIISKKPEGQQVTDRAIPVAIFQAEESVKRFYLSKWLKSKDLQDFDIRNILDWDYYINRFSSNIQKIITIPAALQEVPNPVPRVAHPDWLHKILMEKDNRFKQQRITDIFQTITPSQAAADKMK---DIENCA-PISKKKPTGVTSLKRARNKDTVDVYGVQLDMDNLPNHWRDILGDPVPKGNSKSQFIVWLEFHXXXXXXXXXXXDQSELSKENIN-PATVKRIKTVKKGIQSGISSFFTRSKQSILEDTWQIIQITDTNVSGIYRVWVLIGQEIHNMKLTVPRTFYVNTRIPKAPGENMYFKQVHKLLPRSRIVYHLYEYNLDETIFIKHRSDILSEFIRNEVEGIYELEVPLLLRVYAKLGCMCSIDRNHFTDQQLSNNPSSFLLNELKFRSTAQHPYLSPNSIKTTFLFQQKSNRNEIIGWFDPCNNRAHLCLVEQSKPNPDKFQANVVQSWFSREREAFLSLKENESLISVVPEHVQFEVSSHKFEISAFKAINKLLVAHRNEVTTPTFIATKSKMTINELYSNLPALQEYPLVPITINETDVSFNVLDWQRIAIKSALQNFVKYEKLLAEMLERARYLHIPVGNMSKFTNDYRGISDSYDLFYGRFLMKNNFIWWCNDKSEPDLGKKENQDRRMMLVDNDVLNGMIYRNKPGCYPTTCVQLEMTYFPINTIIAMHKVMEIDGTNERLFESMIVPAKTIDQAMIQSKCNAAKRNLNLTSNTMYDDVTAAGPAFKILRNVILQWLDDVRNYKNPVADEHLMGFYKWMKNSRSLFYDPALFKSLQKLMRMVFFKLIEQLNNLGVEVIYGTLNKIVLCTKRTDLMDALVHVEYATKTVRNQDIFSQLDFQYVSGWDYLIWQDVSNYSGIKSDLES 5864
            +++ R +  D +D  +GF+       +TGWLINM  T+ +DD+KR++SA+ YYF++EDGS+FK  L F+PYFYI TK  CE E+ +YL KKY   +  +EI+ KEDLDL NHL+GLK+ ++KL F+T+DDL++V++EI P +++N++ ++S++ Y+ ML     G       E    K   D +DN +D+REYDVPYHVR+SID  I +  WY+V    +   P    I  R D+V+ P+P+VLA+DIETTKLPLKFPDA  DQIMMISYMIDG G+LI NREI+++DIEDFEFTP+PE+ GPF+VFNE +E   I+R+F+H++E KPNIFVTYNGDFFDWPFVETRA  HGL M   IGF KDNQ EYK+  AIHMDC +WV+RDSYLP+G+  LKA  KAKL Y+PVE+DPEEMC++A E+P+TLA YSVSDAVATYYLYMKYVHPFIFALCTIIPM+PDEVLRKGSGTLCE LLMV+AF++NI+FPNKQE   N LTNDGHV++SETYVGGHVEA+ESGVFRSDIP +FK+ P    FL + ++ TL H +E EE + ++ V NF+EV + I +KL  L+E   R ECP+IYHLDV AMYPNIIL+NRLQPSA+V+E TC ACDFN P A C+R MTW+WRGEIMPA++SE++ IQ QLE EKFPP  P+   R+F+EL++ EQA  EK+RLG +CR AY + H TR EER   +CQREN+FYVDTVRAFRDRRY++K L KV KK+L    + E GDA+E+KR   M +LY+SLQLAHKCILNSFYGYVMRKGARWYSMEMAGIVC TGA II  ARE+IEQIGRPLELDTDGIWC+LP +FP+ F  ++ N KK  ++ SYPGAMLN+MV++ FTN QY +LVDPA  TY  R+ENSIFFEVDGPYLAMILPASKE  KKLKKRYAVFN D SLAELKGFEVKR GEL LIKIFQSSVFE+FLKG+++  VY  VA VA+YWLD+LYS+A+ MPD ELFELISE R MS+KLE+YG+QKSTSISTA+RLAEFLGD+MVKDAGLS +FIIS+KPEG  VT+RAIP+AIFQAE SVK+ YL KWLK   L D DIR+ILDW YYI R  S IQKIITIPAALQ+V NPVPRV HPDWLHK L+EK++ +KQ++I+++F +    Q    K+    D+E+   P    +P  + S KR R     D      +++ L   WR+ILG P PKG +K + +VWL +HKKKW++Q   + +    +  ++  A       ++ G  +G+ SF  R+ +SIL+  WQI+QI +T+  G+Y++W +IG ++H MKL +PR FYVN R+PK   E   +K+V+++LPRS +VY+LY+Y++ E ++ +H ++I ++    ++EG+YE +VPLL R  A+LGC+C +++     +       +F L  L+ RS AQ  YL P S++  +L+        + G F P   +A++ +++  + N    Q   + + +  ER A L  K +E L+   PE   FEV +     + ++A+ ++L++++ E   PT IA +S   +  L + +  L+E+P+VP+ + + ++S+NVLDWQR   +  +++++  +  L++  + ARY H+PVGN+ +  + +       DLF  R L K+N + W +  + PDLG KE  D R+++  ++   G +  N  GCY T CV+L++    +NTI+    + +++G       S+ V    I Q+ ++   +    N   ++   YD+       F+IL+++++ W+ ++  Y N  AD  +M FY+W+++  SL YDPAL  +L  +M+ +F +L+ +   LG  V+YG  N+I+L TK+  + DA+ +VEY T ++ +++IF  L   +   W++L+W D +NY G+K  L S
Sbjct:   32 KRLERSQFTDGMDTRFGFERMKEPGEKTGWLINMHPTEILDDDKRMISAVDYYFIQEDGSRFKVALPFKPYFYIATKKNCEREVVSYLSKKYQGKVAKLEIVPKEDLDLPNHLVGLKRNYIKLSFNTVDDLIKVKREISPAVRKNREREKSNDAYTSMLCSVLAGGNMMTTDEDGTSKKMSDQLDNIVDMREYDVPYHVRLSIDLKIHVAHWYNVRYRGSAYPPE---IVRRDDLVERPDPVVLAFDIETTKLPLKFPDAETDQIMMISYMIDGQGFLITNREIVSEDIEDFEFTPKPEYEGPFTVFNEADEAALIQRWFEHVQETKPNIFVTYNGDFFDWPFVETRAAVHGLSMHQEIGFQKDNQGEYKASQAIHMDCLRWVKRDSYLPVGSHNLKAAAKAKLSYDPVELDPEEMCRMATEEPQTLATYSVSDAVATYYLYMKYVHPFIFALCTIIPMEPDEVLRKGSGTLCEALLMVQAFHANIVFPNKQEQVFNKLTNDGHVLDSETYVGGHVEALESGVFRSDIPCRFKMNPAAFDFLLQRVERTLRHAVEEEENIPLEQVTNFNEVCDEIKKKLISLKEVPNRIECPLIYHLDVGAMYPNIILTNRLQPSAMVDEATCAACDFNKPGANCQRRMTWQWRGEIMPASRSEFHRIQQQLESEKFPPLFPNGRPRAFHELNREEQARHEKKRLGDYCRKAYKKVHLTRLEERVTTICQRENSFYVDTVRAFRDRRYEFKGLHKVWKKKLSS--AQEIGDAAEVKRCKNMEILYESLQLAHKCILNSFYGYVMRKGARWYSMEMAGIVCHTGANIITQARELIEQIGRPLELDTDGIWCVLPNTFPENFVIKSTNEKKPKVTISYPGAMLNIMVKEGFTNHQYQELVDPASLTYETRAENSIFFEVDGPYLAMILPASKEEGKKLKKRYAVFNEDGSLAELKGFEVKRRGELQLIKIFQSSVFEAFLKGTTLERVYDSVAKVADYWLDVLYSKAANMPDAELFELISENRSMSRKLEDYGEQKSTSISTAKRLAEFLGDQMVKDAGLSCRFIISRKPEGSPVTERAIPLAIFQAEASVKKHYLRKWLKMPSLHDLDIRSILDWSYYIERLGSAIQKIITIPAALQQVKNPVPRVRHPDWLHKKLLEKNDIYKQKKISELFTSEGKRQVTQQKLDEAPDMEDFGVPQRPLQPAILISTKRKRASQGEDSQAESQELE-LTQSWREILGPPPPKGTTKEERLVWLRYHKKKWELQIRQRKERRKKRRLMDGEAQPTGGGVIRGGPTTGLGSFLRRTARSILDMPWQIVQIAETSHPGLYKLWAVIGSDLHCMKLNIPRVFYVNQRVPKQE-EGATYKKVNRILPRSNVVYYLYQYSVPEDMYQEHINEINADLSAPDIEGVYETQVPLLFRALAQLGCVCMVNK-QVVRELAGREADTFDLEHLEMRSLAQFSYLEPGSVRHMYLYHHSQGHKALFGLFIPSQRKANVFVLDTVRSN----QMPNLSTLYGAERTALLE-KTSEDLLP--PEKHLFEVRAENDIKAIYRALQRILLSYKEERRGPTLIAVQSNWDLRRLAAGMGVLEEFPVVPVHVTD-EISYNVLDWQRHGARRMIKHYLNLDSCLSQAFDMARYYHLPVGNLPEDISIF-----GSDLFLARHLRKHNHLLWLSPTARPDLGGKEADDSRLVMESDE--RGSVEINTQGCYSTVCVELDIQSLAVNTILQSQHINDMEGG-----ASLGVSFDVIQQSSLEDMMSG---NQGASAVASYDETALCSNTFRILKSMVVGWVREITQYHNVYADNQVMHFYRWLRSPSSLLYDPALHCTLLNMMKKLFLQLVAEFKRLGSSVLYGNFNRIILSTKKRRIDDAIAYVEYITNSIHSREIFHSLSITFSRCWEFLMWMDPANYGGVKGKLPS 1929
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BLAST of DNA polymerase epsilon catalytic subunit vs. Ensembl Sea Lamprey
Match: ENSPMAT00000002970.1 (pep scaffold:Pmarinus_7.0:GL476977:35626:117313:1 gene:ENSPMAG00000002616.1 transcript:ENSPMAT00000002970.1 gene_biotype:protein_coding transcript_biotype:protein_coding)

HSP 1 Score: 1974.52 bits (5114), Expect = 0.000e+0
Identity = 1023/2342 (43.68%), Postives = 1466/2342 (62.60%), Query Frame = 3 
Query:  105 KILRLKKNDQIDLVYGFDLHSAIKIRTGWLINMKTTDAIDDNKRLVSAMSYYFLEEDGSKFKSTLIFQPYFYIVTKLGCESEIQTYLMKKYSACLHNIEIIEKEDLDLDNHXXXXXXXXXXXXXHTIDDLVRVRKEIMPKIKQNQKNQESDNDYSKMLTEHFQGE---KKYEYNARKSALDIMDNAIDIREYDVPYHVRVSIDTAIFIGKWYDVHGSMNIKGPN-STHITPRSDIVDHPEPIVLAYDIETTKLPLKFPDATFDQIMMISYMIDGMGYLICNREIIADDIEDFEFTPRPEFPGPFSVFNEPNEKRTIERFFDHIREVKPNIFVTYNGDFFDWPFVETRAVKHGLDMLDYIGFSKDNQNEYKSRSAIHMDCFKWVQRDSYLPIGAQGLKAVCKAKLRYNPVEVDPEEMCKVAREDPRTLANYSVSDAVATYYLYMKYVHPFIFALCTIIPMDPDEVLRKGSGTLCECLLMVEAFNSNIIFPNKQESKLNPLTNDGHVIESETYVGGHVEAIESGVFRSDIPTKFKIVPEMCKFLRKNLKETLVHVLEVEEKVTVDSVLNFDEVYNAIDEKLEDLEETNIRFECPVIYHLDVAAMYPNIILSNRLQPSALVNEKTCGACDFNVPNAKCKRPMTWKWRGEIMPATKSEYYLIQNQLEKEKFPPKKPSLPMRSFYELDKLEQATVEKERLGKFCRNAYNRKHNTRFEERTAVVCQRENAFYVDTVRAFRDRRYQYKDLTKVSKKRLDELISSENGDASEIKRANGMLVLYDSLQLAHKCILNSFYGYVMRKGARWYSMEMAGIVCSTGAAIIKYAREMIEQIGRPLELDTDGIWCILPASFPQGFEFQTNNPKKRNISFSYPGAMLNLMVQQYFTNDQYH--DLVDPAKHTYRIRSENSIFFEVDGPYLAMILPASKEMNKKLK---KRYAVFNRDRSLAELKGFEVKRNGELNLIKIFQSSVFESFLKGSSISEVYQHVAIVANYWLDLLYSRASTMPDEELFELISEKRCMSKKLEEYGKQKSTSISTARRLAEFLGDEMVKDAGLSFKFIISKKPEGQQVTDRAIPVAIFQAEESVKRFYLSKWLKSKDLQDFDIRNILDWDYYINRFSSNIQKIITIPAALQEVPNPVPRVAHPDWLHKILMEKDNRFKQQRITDIFQT---------ITPSQAAADKMKDIENCAPISKKKPTGVTSLKRARNKDTVDVYGVQLDMDNLPNHWRDILGDPVPKGNSKSQFIVWLEFHXXX-XXXXXXXXDQSE---LSKENINPATVKRIKTVKKG--IQSGISSFFTRSKQSILEDTWQIIQITDTNVSGIYRVWVLIGQEIHNMKLTVPRTFYVNTRIPKAPGENMYFKQVHKLLPRSRIVYHLYEYNLDETIFIKHRSDILSEFIRNEVEGIYELEVPLLLRVYAKLGCMCSIDRNHFTDQQLSNNPSSFLLNELKFRSTAQHPYLSPNSIKTTFLFQQKSNRNEIIGWFDPCNNRAHLCLVEQSKPNPDKFQANVVQSWFSREREAFLSLKENESLISVVPEHVQFEVSSHKFEISAFKAINKLLVAHRNEVTTPTFIATKSKMTINELYSNLPALQEYPLV---------PITINETDVSFNVLDWQRIAIKSALQNFVKYEKLLAEMLERARYLHIPVGNMSKFTNDYRGISDSYDLFYGRFLMKNNFIWWCNDKSEPDLGKKENQDRRMMLVDNDVLNGMIYRNKPGCYPTTCVQLEMTYFPINTIIAMHKVMEIDGTNERLFESMIVPAKTIDQAMIQSKCNAAKRNLNLTSNTMYDDVTAAGPAFKILRNVILQWLDDVRNYKNPVADEHLMGFYKWMKNSRSLFYDPALFKSLQKLMRMVFF--KLIEQLNNLGVEVIYGTLNKIVLCTKRTDLMDALVHVEYATKTVRNQDIFSQLDFQYVSGWDYLIWQDVSNYSGIKSDLESVTKEEHNSMVLEELSFVNMTNPSLSMGLSQSQNEDSFLTTEIADSSQIEMNWHLSRYLSPMSGVQLRLIEILQYFMLTNWKIVKDEYKLNRLAAKNDVAEEAVNTGTILGSDASLYPSSVQRMEDFLQNEMGYKLYLLVSQL-KDVPRMHNAVPLTTXXXXXXXXXXXSNKTPPLLPLKNKVSLHPIVDLIKTTCHILALDTSARYYVNDWKRNMFKLINFDAYSDQAKWRSPYSSDQSMGDAFRSDLIITVPEVICDNCNVTRDLDLCRD--LYQVRIKNSWWFVCPTCDFPYDRNVIQETLIDQVRCICESNVMQDLKCTKCTNGILETSLAGTENCVKCGNAIQVTQNAASLKEKIKIYADIGKHYDLPYLHMMTSWMLQGEDL 7016
            ++ R ++ D++DL +GF         TGWLINM  TD +D++KRL SA+ YYF+ EDGS+FK  L F+PYFY+ TK GCE E+ ++L +++   L  IE++ KEDLDL NHL+GLK+ ++KL F T +DL++VRK++ P I++N++ ++S++ Y+ ML+    G     + E N++K + D M+N  DIREYDVPYHVRV+ID  I +  WY+V     I+G      IT R D+V+ P+P+VLA+DIETTKLPLKFPDA  DQIMMISYM+DG GYLI NRE++++DIEDFEFTP+PE+ GPF++FNE +E   ++RFFDH+ E KPNIFVTYNGD FDWPFVE RA+ HGLD+L   GF KD+Q EYK+  A+HMDC +WV+RDSYLP+G+  LKA  KAKL Y+PVE+DPEEMC++A E+ +TLA YSVSDAVATYY+YMKYVHPFIFALCTIIPM+PDEVLRKGSGTLCE LLMV+AF++NI+FPNKQ+ + N LT DGHV++SETYVGGHVEA+E GVFRSDIP +FK+ P + + L + ++ TL H LE EEK+ +D V NF EV   +  KL  L+E   R ECP+IYHLDV AMYPNIIL+NRLQPSA+V+E TC ACDFN P A C+R M W+WRGE MPAT+SE++ IQ QLE EKFP   P  P R+F+ L + +QA  EK+RL  +C  AY +   TR EER   VCQREN+FYVDTVRAFRDRRY +K L KV K++L    ++++GDA+E+KR   M +LYDSLQLAHKCILNSFYGYVMRKGARWYSMEMAGIVC TGA II  ARE++EQIGRPLELDTDGIWC LP+SFP+ F F T++ +K  ++ SYPGAMLN++V+  +  + +    L  P +      +  ++ F      +A++L +S++    L+   K YAVFN D SLAELKGFEVKR GEL LIKIFQSSVFE+FLKGS++ EVY  VA VA+YWLD+LYS+A+ MPD+ELFELI+E R MS+KLE+YG QKSTSISTARRLAEFLGD+MVKDAGLS +F+IS++PEG  VT+RAIP+AIFQAE SV + YL KWLKS   QDFDIR+ILDWDYYI R  S IQKIITIPAALQ+V NPVPRV HPDWLHK L+EK + +KQ++I ++F           ++  QA A  ++D+E+    S+  P G   +   R +  V+    +     L   WR+ILG P   G +  +   W+ FHKKK     +  KD+S+          P T      ++ G  + +G+  F  R+ +S+L   WQI+QI +   +G++RVW ++G E+H +KL +PR FYVN R+ K P E   +++V+++LPRS  V +LYEY + E ++ +H + I ++     +EG+YE +VPL+ R   +LGC+C++ R     QQ + +  +F L +L+ RS AQ+ YL P +I+  +L+        ++G F P   +A + +V+  + N    Q   +   F+ ER A L+    E L    PEH  FEV        A++ + +LL+++++    PT +A +S      + S +P L  +P+V         P    +   S +VLDWQR   +  ++ +++ +  LA M + ARYLH+PVGN+      +       DLF+ R L +NN + W +    PDLG KE  D R+     D  +  I  + P  Y   C +L++    +N ++  H + +++G           P  ++   M     +    N  L S   YD+       F++L+ +++ W+ ++  ++N  AD  +  F++W+ +  SL YDPAL ++L   M+ +F   +LI +   LG +++Y   N+I++CT++  + DA+ ++EY T+++ +++IF  +   Y   W+ L+W D  NY+GI   L     E+       + S V + +   S        +      +  D S+++ +W+L+ +L   +  Q   + I+  +++  +  +++E K N       V      + +   ++    P +    ++++  E+ + L+ +  ++ + V    NA  L+                 P LP  +    +P ++     C +L+LD +    V+  +R++ +L++   +S  A++R P              L + +PE+IC +CN  RD+DLCR+  L Q       W  C  C   YD   +Q  L++ V+    S+V+QDL C KC  G+ E ++        C    Q+   A    E++K++ +I +HY +P+L    +W+LQG  +
Sbjct:   20 RLERSRQVDEMDLKFGFVRLRDPGEHTGWLINMHPTDILDEDKRLTSAVDYYFIREDGSRFKVALPFKPYFYVATKKGCEREVSSFLSRRFQGKLSGIEMVAKEDLDLPNHLVGLKRTYIKLSFITTEDLIKVRKDVFPAIRKNREREKSNDAYTSMLSSALSGGNLLAEDEGNSKKMS-DQMENITDIREYDVPYHVRVAIDLKIHVAHWYNV----RIRGSAFPPEITRRDDLVERPDPVVLAFDIETTKLPLKFPDAETDQIMMISYMVDGQGYLITNREVVSEDIEDFEFTPKPEYEGPFTIFNEADEAGLLQRFFDHLHETKPNIFVTYNGDSFDWPFVERRALAHGLDLLIETGFQKDSQGEYKATQALHMDCLRWVKRDSYLPVGSHNLKAAAKAKLGYDPVELDPEEMCRMAAEEAQTLATYSVSDAVATYYMYMKYVHPFIFALCTIIPMEPDEVLRKGSGTLCEALLMVQAFHANIVFPNKQQEEFNRLTGDGHVLDSETYVGGHVEALECGVFRSDIPCRFKMNPGVFEELMEKVETTLKHALEEEEKIPLDKVNNFSEVCEEVRSKLRALQEVPSRIECPLIYHLDVGAMYPNIILTNRLQPSAMVDEATCAACDFNKPGASCQRRMAWQWRGEFMPATRSEFHRIQQQLESEKFPSMFPGGPPRAFHTLSREDQAKYEKKRLADYCHKAYKKVRVTRMEERMTTVCQRENSFYVDTVRAFRDRRYDFKGLHKVWKRKLGS--AADSGDAAEVKRCRNMEILYDSLQLAHKCILNSFYGYVMRKGARWYSMEMAGIVCHTGANIIMQARELVEQIGRPLELDTDGIWCALPSSFPENFIFHTSSAEKPKVTVSYPGAMLNILVKSGYDKNMFTFWKLCQPKQIKPTTFTNKTLIFSGYPISIAILLTSSRKRVSHLQVFFKWYAVFNEDGSLAELKGFEVKRRGELQLIKIFQSSVFEAFLKGSNLQEVYAAVAKVADYWLDVLYSKAANMPDQELFELIAENRSMSRKLEDYGAQKSTSISTARRLAEFLGDQMVKDAGLSCRFVISRRPEGAPVTERAIPLAIFQAEPSVSKHYLRKWLKSPSQQDFDIRSILDWDYYIERLGSAIQKIITIPAALQQVKNPVPRVRHPDWLHKKLLEKSDAYKQKKINELFTASEKRQLTVKVSGQQAGAASVEDMEDFG-ASQLTPLGPVPMATKRKRAEVESQDRESQDLELTQTWREILGPPPSIGTTAEEMATWIRFHKKKWEIQTRQRKDRSKRRRCGSGEGGPTTHGARGPLRGGGALNTGLGGFLMRAARSLLSTPWQIVQIAEGTQAGMFRVWCVVGTELHVVKLHIPRIFYVNQRVAK-PDEGPNYRKVNRVLPRSNPVLNLYEYTVAEELYQQHLNQINADLAAPHIEGVYETQVPLMFRALVQLGCVCTVSRES-ARQQGALDVDTFQLEQLEMRSLAQYSYLEPGTIRHMYLYHCSQGSKALLGLFIPTQRKASVFVVDTVRSN----QMPNLGVVFTAERAALLASLGEELLPP--PEH-GFEVRVETDLKQAYRGLQRLLLSYKDSRKGPTLVAVESAWPSQRVRSAMPVLDNFPVVWVGGAGATSPAGPADDPPSLSVLDWQRQGGRHMVRAYLRVDSTLARMFDVARYLHVPVGNLPDDVEAF-----GCDLFFARHLRRNNHLLWLSATGRPDLGGKEADDGRLACDTRDAKSFHI--SCPSAYHAVCAELDIQSLAVNAVLQSHHINDLEGGASGGVSFDSAPQASLADMMT----SGTSSNTALAS---YDEAALCSNTFRVLKGMVVGWVREISRFQNAYADNQVTHFHRWVSSPASLLYDPALHRTLHTAMKKLFLQCRLISEFKRLGSQIVYADFNRIIVCTRKHHIEDAIAYMEYVTRSINSREIFHSISISYSRCWETLLWLDSCNYAGIVGQLPPALLEKIRKRKPSDGSNVEI-DYECSEEEDDGNEDGGDDEEDALDESRLDNHWNLALFLPQAASCQTYFLTIVTAYIMAVYHSLQEEMKRNE-PGDTPVKRRGHGSQSTQAANKDGLPGTTSFCQEYVAGELTHNLFTITQKIQRRVTGRRNADGLSPLF--------------PELPGSHLPLANPALEFASFVCGVLSLDGAVALQVSKLRRDLLRLLDVGEFSSDAEFRDPC-------------LSLVLPELICHHCNYCRDIDLCREPALAQDGSVLPKW-QCTNCSADYDVEQVQAALVETVQKKIMSHVLQDLVCEKC-KGVKEANMPAF---CDCAGDFQLAHPAQEFVEQLKVFRNIARHYAMPFLLETVNWILQGSSV 2296
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BLAST of DNA polymerase epsilon catalytic subunit vs. Ensembl Yeast
Match: POL2 (Catalytic subunit of DNA polymerase (II) epsilon; a chromosomal DNA replication polymerase that exhibits processivity and proofreading exonuclease activity; participates in leading-strand synthesis during DNA replication; also involved in DNA synthesis during DNA repair; interacts extensively with Mrc1p [Source:SGD;Acc:S000005206])

HSP 1 Score: 1392.87 bits (3604), Expect = 0.000e+0
Identity = 854/2346 (36.40%), Postives = 1254/2346 (53.45%), Query Frame = 3 
Query:  102 EKILRLKKNDQIDLVYGFDLH--------------SAIKIRTGWLINMKTT--------------DAIDDNKRL-----VSAMSYYFLEEDGSKFKSTLIFQPYFYIVTKLGCESEIQTYLMKKY-SACLHNIEIIEKEDLDLDNHXXXXXXXXXXXXXHTIDDLVRVRKEIMPKIKQNQKNQESDNDYSKMLTEHFQGEKKYEYNARKSALDIMDNAIDIREYDVPYHVRVSIDTAIFIGKWYDVHGSMNIKGPNSTHITPRSDIVDHPEPIVLAYDIETTKLPLKFPDATFDQIMMISYMIDGMGYLICNREIIADDIEDFEFTPRPEFPGPFSVFNEPNEKRTIERFFDHIREVKPNIFVTYNGDFFDWPFVETRAVKHGLDMLDYIGFSKDNQNEYKSRSAIHMDCFKWVQRDSYLPIGAQGLKAVCKAKLRYNPVEVDPEEMCKVAREDPRTLANYSVSDAVATYYLYMKYVHPFIFALCTIIPMDPDEVLRKGSGTLCECLLMVEAFNSNIIFPNKQESKLNPLTNDGHVIESETYVGGHVEAIESGVFRSDIPTKFKIVPEMCKFLRKNLKETLVHVLEVEEKVTVDSVLNFDEVYNAIDEKLEDLEETNIRFECPVIYHLDVAAMYPNIILSNRLQPSALVNEKTCGACDFNVPNAKCKRPMTWKWRGEIMPATKSEYYLIQNQLEKEKFPPKK--PSLPMRSFYELDKLEQATVEKERLGKFCRNAYNRKHNTRFEERTAVVCQRENAFYVDTVRAFRDRRYQYKDLTKVSKKRLDELISSENGDASEIKRANGMLVLYDSLQLAHKCILNSFYGYVMRKGARWYSMEMAGIVCSTGAAIIKYAREMIEQIGRPLELDTDGIWCILPASFPQGFEFQTNNPKKRNISFSYPGAMLNLMVQQYFTNDQYHDLVDPAKHTYRIRSENSIFFEVDGPYLAMILPASKEMNKKLKKRYAVFNRDRSLAELKGFEVKRNGELNLIKIFQSSVFESFLKGSSISEVYQHVAIVANYWLDLLYSRASTMPDEELFELISEKRCMSKKLEEYGKQKSTSISTARRLAEFLGDEMVKDAGLSFKFIISKKPEGQQVTDRAIPVAIFQAEESVKRFYLSKWLKSKDLQDFDIRNILDWDYYINRFSSNIQKIITIPAALQEVPNPVPRVAHPDWLHKILMEKDNRFKQQRITDIFQTITPSQAAADKMKDIENCAPISKKKPTGVTSLKRARNKDTVDVYGVQLDMDNLPNHWRDILGDPVPKGNSKSQFIVWLEFHXXXXXXXXXXXDQSELSKENINPATVKRIKTVKKGIQSGISSFFTRSKQSILEDTWQIIQITDTNVSGIYRVWVLIGQEIHNMKLTVPRTFYVNTR---IPKAPGENMYFKQVHKLLPRSRIVY-----HLYEYNLDETIFIKHRSDILSEFIRNEVEGIYELEVPLLLRVYAKLGCMCSIDRNHFTDQQLSNNPSSFLLNELKFRSTAQHPYLSPNSIKTTFLFQQKSNRN-EIIGWFDPCNNRAHLCLVEQSKPNPDKFQANVVQSWFSREREAFLSLKENESLISVVPEHVQFEVSSHKFEISAFKAINKLLVAHRNEVT------TPTFIATKSKMTINELYSNLPALQEYPLVPITINETDVSFNVLDWQRIAIKSALQNFVKYEKLLAEMLERARYLHIPVGNMSKFTNDYRGISDSYDLFYGRFLMKNNFIWWCNDKSE-PDLGKKENQ-DRRMMLVDNDVLNGMIYRNKPGCYPTTCVQLEMTYFPINTIIAMHKVMEIDGTNERLFESMIVPAKTIDQAMIQSKCNAAKRNLNLTSNTMYDDVTAAGPAFKILRNVILQWLDDVRNYKNPVADEHLMGFYKWMKNSRSLFYDPALFKSLQKLMRMVFFKLIEQLNNLGVEVIYGTLNKIVLCTKRTDLMDALVHVEYATKTVRNQDIFSQLDFQYVSGWDYLIWQDVSNYSGIKSDLESVTKEEHNSMVLEELSFVNMTNPSLSMGLSQSQNEDSFLTTEIADSSQIEMNWHLSRYLSPMSGVQLRLIEILQYFMLTNWKIVKDEYKLNRLAAKNDVAEEAVNTGTILGSDASLYPSSVQRMEDFLQNEM-GYKLYLLVSQLKDVPRMHNAVPLTTXXXXXXXXXXXSNKTPPLLPLKNKVSLHPIVDLIKTTCHILALDTSARYYVNDWKRNMFKLINFDAYSDQAKWRSPYSSDQSMGDAFRSDLIITVPEVICDNCNVTRDLDLCRDLYQVRIKNSWWFVCPTCDFPYDRNVIQETLIDQVRCICESNVMQDLKCTKCTNGILETSLAGTENCVKCGNAIQVTQNAASLKEKIKIYADIGKHYDLPYL 6977
            +++L   K D ID + GF+ +                I  R GWL NM  T                 +D +R+     +S + +YFL+E+G  FKST+++ PYF+I             L+KKY  +CL +++II KEDL +DNHL+GL+K  +KL F   + L   RK + P ++ N  N    N Y+        G +K         +D      DIREYDVPYHVRVSID  I +GKWY V     I+             +   +P+V+A+DIETTK PLKFPD+  DQIMMISYMIDG G+LI NREII++DIEDFE+TP+PE+PG F++FNE +E   ++RFF+HIR+V+P +  T+NGDFFDWPF+  R+  HGLDM D IGF+ D + EYKS    HMDCF+WV+RDSYLP G+QGLKAV ++KL YNP+E+DPE M   A E P+ L+ YSVSDAVATYYLYMKYVHPFIF+LCTIIP++PDE LRKG+GTLCE LLMV+A+  NI+ PNK    +     DGH++ESETYVGGHVE++E+GVFRSD+  +FKI P     L + L E L   +EVE K +VD V NF+E+ N I +KL +L+E NIR E P+IYH+DVA+MYPNI+ +NRLQP ++  E+ C +CDFN P   C R + W WRGE  P+   EY +I+  L+ E FP K       + +F EL   +Q    K+RL ++ R  Y+R   +   ER A+VCQREN FYVDTV++FRDRRY++K L K  K  L ++  S+     E K+   M+VLYDSLQLAHK ILNSFYGYVMRKG+RWYSMEMAGI C TGA II+ AR ++E++GRPLELDTDGIWCILP SFP+ + F   N KK  +  SYP +MLN  V Q FTN QY +L DP  + Y   SEN+IFFEVDGPY AMILP+SKE  K +KKRYAVFN D SLAELKGFE+KR GEL LIK FQS +F+ FL+G ++   Y  VA V N WLD+L S    + DE+L  LI E R MSK L+EY  QKSTSI+TARRL +FLG++MVKD GL  K+IIS KP    VT+RAIPVAIF A+  +KR +L +W     L+D DIR I+DW YY  R  S IQKIITIPAALQ V NPVPRV HPDWL + +  K+++FKQ  +T  F   T +     K+KDIE+    + ++      + R   K  V     +   + L N   D L  P    +    ++ WL + K KWKIQ   + + +    N N +  +          S + S   +  +S    TW+++Q  D+   G+  V+V I  ++ N+   +P+T Y+  +   +P    +N   ++    LP +          L++  L E++F++ + +  S F    V G++E  +    R    LG   +  R+             F + +L      +  YLS  S+   +L    ++   E    F    +   + +++ S     +  A+ +   + +  E      E  S +  + E +        FE   F  I+KL      E T         F+       I +L   +  L + P+V +++NE  V    L+WQ   +K  + + +     ++ +++ ++Y +IP+ N+   + DY       D+ Y R L K N + W N+K+  PD G  +N  D     + ND     I  N  G Y    + + +    +NTI+    + + +G++                 ++ +      ++  + S + +     +  A  +LR ++ +W D+    +N  AD  +     W++N  +  +D  L   +  L +    +L+ + + LG  ++Y   N+I++ T +    +   + +Y  K VR   +FS LD      WD LIW D  N+SG+                               + + + +N+D    ++          W L ++LSP+   +        + M+    ++K +    +L +      + VN                Q  ED ++N + G+        +K V ++          +   + + E++   P+LP  +    +P+++L+K+ CH++ L  S    +   ++ + K+     ++  A+++ P              L + VP+ +C+ C    D+D C+   +        F C  C   +++ ++QE LI ++R   ES ++QDL+C++C     +   A   +C  C  A + T    S+ +K+ ++  + K+Y    L
Sbjct:   35 QQLLNASKIDDIDSMMGFERYVPPQYNGRFDAKDIDQIPGRVGWLTNMHATLVSQETLSSGSNGGGNSNDGERVTTNQGISGVDFYFLDEEGGSFKSTVVYDPYFFIACNDESRVNDVEELVKKYLESCLKSLQIIRKEDLTMDNHLLGLQKTLIKLSFVNSNQLFEARKLLRPILQDNANNNVQRNIYNVAAN----GSEK---------VDAKHLIEDIREYDVPYHVRVSIDKDIRVGKWYKVTQQGFIEDTRK---------IAFADPVVMAFDIETTKPPLKFPDSAVDQIMMISYMIDGEGFLITNREIISEDIEDFEYTPKPEYPGFFTIFNENDEVALLQRFFEHIRDVRPTVISTFNGDFFDWPFIHNRSKIHGLDMFDEIGFAPDAEGEYKSSYCSHMDCFRWVKRDSYLPQGSQGLKAVTQSKLGYNPIELDPELMTPYAFEKPQHLSEYSVSDAVATYYLYMKYVHPFIFSLCTIIPLNPDETLRKGTGTLCEMLLMVQAYQHNILLPNKHTDPIERFY-DGHLLESETYVGGHVESLEAGVFRSDLKNEFKIDPSAIDELLQELPEALKFSVEVENKSSVDKVTNFEEIKNQITQKLLELKENNIRNELPLIYHVDVASMYPNIMTTNRLQPDSIKAERDCASCDFNRPGKTCARKLKWAWRGEFFPSKMDEYNMIKRALQNETFPNKNKFSKKKVLTFDELSYADQVIHIKKRLTEYSRKVYHRVKVSEIVEREAIVCQRENPFYVDTVKSFRDRRYEFKGLAKTWKGNLSKIDPSDKHARDEAKK---MIVLYDSLQLAHKVILNSFYGYVMRKGSRWYSMEMAGITCLTGATIIQMARALVERVGRPLELDTDGIWCILPKSFPETYFFTLENGKK--LYLSYPCSMLNYRVHQKFTNHQYQELKDPLNYIYETHSENTIFFEVDGPYKAMILPSSKEEGKGIKKRYAVFNEDGSLAELKGFELKRRGELQLIKNFQSDIFKVFLEGDTLEGCYSAVASVCNRWLDVLDSHGLMLEDEDLVSLICENRSMSKTLKEYEGQKSTSITTARRLGDFLGEDMVKDKGLQCKYIISSKPFNAPVTERAIPVAIFSADIPIKRSFLRRWTLDPSLEDLDIRTIIDWGYYRERLGSAIQKIITIPAALQGVSNPVPRVEHPDWLKRKIATKEDKFKQTSLTKFFSK-TKNVPTMGKIKDIEDLFEPTVEEDNAKIKIARTTKKKAVS----KRKRNQLTNE-EDPLVLPSEIPSMDEDYVGWLNYQKIKWKIQARDRKRRDQLFGNTNSSRER----------SALGSMIRKQAESYANSTWEVLQYKDSGEPGVLEVFVTINGKVQNITFHIPKTIYMKFKSQTMPLQKIKNCLIEKSSASLPNNPKTSNPAGGQLFKITLPESVFLEEKENCTSIFNDENVLGVFEGTITPHQRAIMDLGASVTF-RSKAMGALGKGIQQGFEMKDLSMAENER--YLSGFSMDIGYLLHFPTSIGYEFFSLFKSWGDTITILVLKPSN-QAQEINASSLGQIYKQMFEKKKGKIETYSYLVDIKEDIN-------FEFVYFTDISKLYRRLSQETTKLKEERGLQFLLLLQSPFITKLLGTIRLLNQMPIVKLSLNE--VLLPQLNWQPTLLKKLVNHVLSSGSWISHLIKLSQYSNIPICNLRLDSMDY-----IIDVLYARKLKKENIVLWWNEKAPLPDHGGIQNDFDLNTSWIMNDSEFPKI--NNSGVYDNVVLDVGVDNLTVNTILTSALINDAEGSD-----------------LVNNNMGIDDKDAVINSPSEFVHDAFSNDALNVLRGMLKEWWDEALK-ENSTADLLVNSLASWVQNPNAKLFDGLLRYHVHNLTKKALLQLVNEFSALGSTIVYADRNQILIKTNKYSPENCYAYSQYMMKAVRTNPMFSYLDLNIKRYWDLLIWMDKFNFSGLA-----------------------------CIEIEEKENQDYTAVSQ----------WQLKKFLSPIYQPEFE-----DWMMIILDSMLKTKQSYLKLNSGTQRPTQIVNVKK-------------QDKEDSVENSLNGFSHLFSKPLMKRVKKL-----FKNQQEFILDPQYEADYVIPVLPGSHLNVKNPLLELVKSLCHVMLLSKSTILEIRTLRKELLKIFELREFAKVAEFKDP-------------SLSLVVPDFLCEYCFFISDIDFCKAAPES------IFSCVRCHKAFNQVLLQEHLIQKLRSDIESYLIQDLRCSRCHKVKRDYMSA---HC-PCAGAWEGTLPRESIVQKLNVFKQVAKYYGFDIL 2213
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BLAST of DNA polymerase epsilon catalytic subunit vs. Ensembl Nematostella
Match: EDO36342 (DNA polymerase [Source:UniProtKB/TrEMBL;Acc:A7SIT9])

HSP 1 Score: 2088.15 bits (5409), Expect = 0.000e+0
Identity = 1070/2325 (46.02%), Postives = 1495/2325 (64.30%), Query Frame = 3 
Query:   99 EEKILRLKKNDQIDLVYGFDLHSAIKIRTGWLINMKTTDAIDDNKRLVSAMSYYFLEEDGSKFKSTLIFQPYFYIVTKLGCESEIQTYLMKKYSACLHNIEIIEKEDLDLDNHXXXXXXXXXXXXXHTIDDLVRVRKEIMPKIKQNQKNQESDNDYSKMLTEHFQGEKKYEYNARKSALDIMDNAIDIREYDVPYHVRVSIDTAIFIGKWYDVHGSMNIKGPNSTHITPRSDIVDHPEPIVLAYDIETTKLPLKFPDATFDQIMMISYMIDGMGYLICNREIIADDIEDFEFTPRPEFPGPFSVFNEPNEKRTIERFFDHIREVKPNIFVTYNGDFFDWPFVETRAVKHGLDMLDYIGFSKDNQNEYKSRSAIHMDCFKWVQRDSYLPIGAQGLKAVCKAKLRYNPVEVDPEEMCKVAREDPRTLANYSVSDAVATYYLYMKYVHPFIFALCTIIPMDPDEVLRKGSGTLCECLLMVEAFNSNIIFPNKQESKLNPLTNDGHVIESETYVGGHVEAIESGVFRSDIPTKFKIVPEMCKFLRKNLKETLVHVLEVEEKVTVDSVLNFDEVYNAIDEKLEDLEETNIRFECPVIYHLDVAAMYPNIILSNRLQPSALVNEKTCGACDFNVPNAKCKRPMTWKWRGEIMPATKSEYYLIQNQLEKEKFPPKKPSLPMRSFYELDKLEQATVEKERLGKFCRNAYNRKHNTRFEERTAVVCQRENAFYVDTVRAFRDRRYQYKDLTKVSKKRLDELISSENGDASEIKRANGMLVLYDSLQLAHKCILNSFYGYVMRKGARWYSMEMAGIVCSTGAAIIKYAREMIEQIGRPLELDTDGIWCILPASFPQGFEFQTNNPKKRNISFSYPGAMLNLMVQQYFTNDQYHDLVDPAKHTYRIRSENSIFFEVDGPYLAMILPASKEMNKKLKKRYAVFNRDRSLAELKGFEVKRNGELNLIKIFQSSVFESFLKGSSISEVYQHVAIVANYWLDLLYSRASTMPDEELFELISEKRCMSKKLEEYGKQKSTSISTARRLAEFLGDEMVKDAGLSFKFIISKKPEGQQVTDRAIPVAIFQAEESVKRFYLSKWLKSKDLQDFDIRNILDWDYYINRFSSNIQKIITIPAALQEVPNPVPRVAHPDWLHKILMEKDNRFKQQRITDIFQTITPSQA------AADKMKDIENCAPISKKKPTGV----TSLKRARNKDTVDVYGVQ-----LDMDNLPNHWRDILGDPVPKGNSKSQFIVWLEFHXXX-XXXXXXXXDQSELSKENINPATVKRIKTVKKGIQSGISSFFTRSKQSILEDTWQIIQITDTNVSGIYRVWVLIGQEIHNMKLTVPRTFYVNTRIPKAPGENMYFKQVHKLLPRSRIVYHLYEYNLDETIFIKHRSDILSEFIRNEVEGIYELEVPLLLRVYAKLGCMCSIDRNHFTDQQLSNNPSSFLLNELKFRSTAQHPYLSPNSIKTTFLFQQKSNRNEIIGWFDPCNNRAHLCLVEQSKPNPDKFQANVVQSWFSREREAF-LSLKENESLISVVPEHVQFEVSSHKFEISAFKAINKLLVAHRNEVTTPTFIATKSKMTINELYSNLPALQEYPLVPITINETDVSFNVLDWQRIAIKSALQNFVKYEKLLAEMLERARYLHIPVGNMSKFTNDYRGISDSYDLFYGRFLMKNNFIWWCNDKSEPDLGKKENQDRRMMLVDNDVLNGMIYRNKPGCYPTTCVQLEMTYFPINTIIAMHKVMEIDGTNERLFESMIVPAKTIDQAMIQSKCNAAKRNLNLTSNTMYDDVTAAGPAFKILRNVILQWLDDVRNYKNPVADEHLMGFYKWMKNSRSLFYDPALFKSLQKLMRMVFFKLIEQLNNLGVEVIYGTLNKIVLCTKRTDLMDALVHVEYATKTVRNQDIFSQLDFQYVSGWDYLIWQDVSNYSGIKSDLESVTKEEHNSMVLEELSFVNMTNPSLSMGLSQSQNEDSFLTTEIADSSQIEMNWHLSRYLSPMSGVQLRLIEILQYFMLTNWKIVKDEYKLNRLAAKNDVAEEAVNTGTILGSDASLYPSSVQRMEDFLQNEMGYKLYLLVSQLKDVPRMHNAVPLTTXXXXXXXXXXXSNKTP----PLLPLKNKVSLHPIVDLIKTTCHILALDTSARYYVNDWKRNMFKLINFDAYSDQAKWRSPYSSDQSMGDAFRSDLIITVPEVICDNCNVTRDLDLCRD--LYQVRIKNSWWFVCPTCDFPYDRNVIQETLIDQVRCICESNVMQDLKCTKCTNGILETSLAGTENCVKCGNAIQVTQNAASLKEKIKIYADIGKHYDLPYLHMMTSWMLQ 7004
            E ++LR++  D +D  YGF+ H     + GWLINM  T+ +DD+K+L+SA+  YF+++DG +F+  L F+PYFYI+ K   + E+ T+L +K+   +  IE ++KEDLDL NHL+GLK+ ++KL FHT++DL+++++EIMP + +N++  ++   YS  +     G    E +  K   D  +N IDIREYDVPYHVRV+ID  I +G WY    +  ++G     I  R D++D P+P+VLA+DIETTKLPLKFPD+  D IMMISYMIDG G+LI NREI+++DIEDFE+TP+PE+ G F+  NEP+E+  + RFF+HI EVKPNIFVTYNGD FDWPFVE RA  HG++M++ IGFS D+  EYKSR AIHMD F+WV+RDSYLP+G+Q LKA  KAKLRY+P+E+DPEEMC++A E P+ L+NYSVSDAVATYYLYMKYVHPFIFALCTIIPM+PDEVLRKGSGTLCE LLMV+AF++NIIFPNKQE   N LTNDGHV++SETYVGGHVEA+ESGVFRSDIP +F++VPE  + L  +++ T+ H +E EEK+  D+V+NFDEV N I  KL  L +T  R E P+IYHLDV AMYPNIIL+NRLQPSA+V+E TC ACDFN P ++C+R MTW WRGE MPA+++EY  I+ QLE E+ P   P    RSF++L   EQA +EK+RL  +C  AY +   TR EER   +CQREN+FYVDTVRAFRDRRY++K L KV K++L   + S  GD  EIK      VLYDSLQLAHKCILNSFYGYVMRKGARWYSMEMAGIVC TGA II  ARE++EQIGRPLELDTDGIWC+LPASFP+ ++  T NPKK  ++ SYPGAMLN+MV+ +FTNDQYH+L DP    Y IR+ENSIFFEVDGPY AMILPASKE  KKLKKRYAVFN D SLAELKGFEVKR GEL LIK FQSSVFE FL+G ++ EVYQ VA VAN+WLD+LYS+A  MPD ELF+LI E R MSK LEEYG+QKSTSISTA+RLAEFLGD+MVKD GLS KFIISKKPEG  VT+RAIP+AIFQ E+ V++ YL +WLK   L  FDIR ILDW+YYI R +S IQKIITIPAALQ V NPVPR  HP WLHK L+EK++ FKQQRI+++F  + P +       A+ ++ DIE+ A       T       + KR R  D  D          LD  +L   WR++LGDP   G S  +   W+ F KKK     +   ++  L KE  +   +    T      +G+SSF  +  +++L+  WQI+QI +T   G++RVW LIG ++H +K+ +PR  Y+N+R P+   E   +++V + LPRS    HLYEY++ ET+F +H S + ++    E+EGIYE +VPLL R   KLGC+CS+++  F       +  +F L++L+F++ A+  YL   ++KT +L+   S+   +IG F P   ++ + +++  + N    Q   +   F+ ER A      E++   S+ PE+  FE+        A++A+ +LL+ ++ E   PT +  +S   ++ L S++P L ++PLVP+  +++D  +NVLDWQR A +  ++++++ +  +   LE ARY H+P+GN+S     +     + DLF+ R L K+N I W +    PDLG KE+ D R+ L+ ++V +  +  N  GCYPT CV+L +    +NTI+    + + +G          +P  ++++ ++Q   N A      TS T YD+      AF+IL+ ++  WL +V  Y+N  AD  LM FY+W+ +  ++ YDPAL + +Q++++ +F +L+ +   LG  +I+ + +KI++ TK+  + DAL +V++  K+++++D+F  +D    S W+YL+W D +N+ G++  L S   E+ N    ++   V    P       ++ NED           +IEMNW++ +YL   +  Q     ++   +   +K   +E ++        +     ++ +    ++S  P  V   ++ +Q EM  +L+ +  +++                    G+  SNK P    P+LP  +    +P ++ +   C +LALD++  + VN  +R++ KLI    +S +A ++ P              L   +PEVIC+ CN  RDLDLCRD  +            CP C   Y+   I+  LI  V+      V+QDLKC KC  GI +++++      KC      T +     EK+K + +I +HY +  L     W+++
Sbjct:    3 ESRMLRIQSQDVMDNKYGFERHKDATEKLGWLINMHPTEILDDDKKLISALDLYFIQDDGERFRVALPFKPYFYILAKKDTDREVATWLNRKFGGAIAKIETVQKEDLDLYNHLVGLKRNYIKLSFHTVNDLMKIKREIMPAVNKNKEQAKNTPVYS--MISGANGFDDKEDSTHKRVTDQKENIIDIREYDVPYHVRVAIDLKIHVGHWY----TAKVRGGLYPEIIRRDDLLDRPDPVVLAFDIETTKLPLKFPDSATDSIMMISYMIDGQGFLIINREIVSEDIEDFEYTPKPEYEGQFTCINEPDEEGLLRRFFEHILEVKPNIFVTYNGDSFDWPFVEARASHHGINMMEEIGFSPDSAGEYKSRPAIHMDAFRWVKRDSYLPVGSQNLKATTKAKLRYDPIELDPEEMCRMASEQPQELSNYSVSDAVATYYLYMKYVHPFIFALCTIIPMEPDEVLRKGSGTLCEALLMVQAFHANIIFPNKQEQVFNKLTNDGHVLDSETYVGGHVEALESGVFRSDIPCRFRLVPEAFQKLIDSVENTMKHAIEEEEKIPFDTVINFDEVCNDIKAKLGSLRDTPARLENPLIYHLDVGAMYPNIILTNRLQPSAMVDEATCAACDFNKPGSQCQRAMTWTWRGEYMPASRNEYQTIRQQLEAERIPGLNPGDAPRSFHQLSTAEQAQMEKKRLQDYCHKAYRKIRVTRIEERQTTICQRENSFYVDTVRAFRDRRYEFKGLLKVWKRKLGTAVQS--GDPEEIKSCKSKEVLYDSLQLAHKCILNSFYGYVMRKGARWYSMEMAGIVCHTGANIITRAREIVEQIGRPLELDTDGIWCVLPASFPENYQVVTTNPKKSKVAISYPGAMLNIMVKTHFTNDQYHELSDPENLMYDIRAENSIFFEVDGPYKAMILPASKEEGKKLKKRYAVFNEDGSLAELKGFEVKRRGELQLIKNFQSSVFEQFLQGKTLDEVYQAVAKVANFWLDVLYSKAQNMPDNELFDLICENRSMSKTLEEYGEQKSTSISTAKRLAEFLGDQMVKDKGLSCKFIISKKPEGSPVTERAIPLAIFQTEDGVRKHYLRRWLKDNSLVSFDIREILDWEYYIERLNSAIQKIITIPAALQGVSNPVPRCIHPPWLHKRLLEKNDVFKQQRISEMFSRLPPKEGHSSGGPASSQVTDIEDMANGGTASATNGLIRPVATKRKRGYDDGDTPTTGTGKGYLDQIDLSKSWRELLGDPPKWGPSDEEKNAWVAFQKKKWAHQARQRAERKRLRKEATD---MGMTFTSGGSATTGLSSFIRQKTRTLLDTPWQIVQIAETPTPGLFRVWSLIGSDLHAVKVNIPRILYINSRTPREE-EGTMWRKVSRTLPRSHAAIHLYEYSVKETLFTEHSSALATDLSSPEIEGIYESQVPLLTRALIKLGCVCSVNK-LFAKICRGKDIDTFELDQLEFKTLAESSYLDNFNMKTIYLYHSYSDNKAMIGVFMPGQRKSSVFVIDTVRNN----QMPSLSLMFNTERSARKKKADEDDESFSLPPENHTFEIRVDTNARQAWRAVQRLLMGYKEEKRGPTMVLVQSAWDLSHLTSSVPVLGDFPLVPLPYSDSDAQYNVLDWQRHASRRMIRHYLEVDIYVQAQLEHARYFHVPIGNVSTDPTLF-----AADLFFARHLQKHNHILWMSPTDRPDLGGKEDDDNRLGLMTDEVES--VEFNSSGCYPTVCVELSIDGLAVNTILQSAHINDFEGGAGTGISFDNLPQASLEE-LVQGGSNTA------TSLTTYDEAALCSTAFRILKGMVHSWLHEVSAYQNQYADAQLMHFYRWLSSPSAMLYDPALCRMVQRMIKKLFLQLVGEFKRLGSTIIFASFSKIIISTKKRSVSDALAYVDFILKSIQSKDLFHSIDITPTSCWEYLMWLDKANHGGVRGKLPS--DEDTNGETEDDEDDVLPCTP-------ENNNED----------GEIEMNWNIVKYLPTGASCQNFFQIVIAGHIHAMYKHALEERRIIE-PGTTPIRRRGGSSQSQRAKESSTTPGHVNFAQERIQGEMTQQLFSITQKIQHT----------------LSGDRSSNKDPSSEFPILPGSHLPLNNPALEFVNYVCKVLALDSNTHHQVNKLRRDLLKLIGIGEFSQEATFKDPC-------------LSFVLPEVICEYCNACRDLDLCRDPCIVPAEGNKPASCQCPNCLNEYNMEAIEHQLISAVQKRSMGYVLQDLKCVKC-KGIKDSNMS---RYCKCAGNFTHTSSVDDFAEKMKTFRNIARHYTMTMLLETVEWIMK 2243
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BLAST of DNA polymerase epsilon catalytic subunit vs. Ensembl Medaka
Match: POLE (DNA polymerase epsilon, catalytic subunit [Source:HGNC Symbol;Acc:HGNC:9177])

HSP 1 Score: 1373.22 bits (3553), Expect = 0.000e+0
Identity = 673/1096 (61.41%), Postives = 847/1096 (77.28%), Query Frame = 3 
Query:  102 EKILRLKKNDQIDLVYGFDLHSAIKIRTGWLINMKTTDAIDDNKRLVSAMSYYFLEEDGSK--FKSTLIFQPYFYIVTKLGCESEIQTYLMKKYSACLHNIEIIEKEDLDLDNHXXXXXXXXXXXXXHTIDDLVRVRKEIMPKIKQNQKNQESDNDYSKMLTEHFQG---EKKYEYNARKSALDIMDNAIDIREYDVPYHVRVSIDTAIFIGKWYDVHGSMNIKGPNSTHITPRSDIVDHPEPIVLAYDIETTKLPLKFPDATFDQIMMISYMIDGMGYLICNREIIADDIEDFEFTPRPEFPGPFSVFNEPNEKRTIERFFDHIREVKPNIFVTYNGDFFDWPFVETRAVKHGLDMLDYIGFSKDNQNEYKSRSAIHMDCFKWVQRDSYLPIGAQGLKAVCKAKLRYNPVEVDPEEMCKVAREDPRTLANYSVSDAVATYYLYMKYVHPFIFALCTIIPMDPDEVLRKGSGTLCECLLMVEAFNSNIIFPNKQESKLNPLTNDGHVIESETYVGGHVEAIESGVFRSDIPTKFKIVPEMCKFLRKNLKETLVHVLEVEEKVTVDSVLNFDEVYNAIDEKLEDLEETNIRFECPVIYHLDVAAMYPNIILSNRLQPSALVNEKTCGACDFNVPNAKCKRPMTWKWRGEIMPATKSEYYLIQNQLEKEKFPPKKPSLPMRSFYELDKLEQATVEKERLGKFCRNAYNRKHNTRFEERTAVVCQRENAFYVDTVRAFRDRRYQYKDLTKVSKKRLDELISSENGDASEIKRANGMLVLYDSLQLAHKCILNSFYGYVMRKGARWYSMEMAGIVCSTGAAIIKYAREMIEQIGRPLELDTDGIWCILPASFPQGFEFQTNNPKKRNISFSYPGAMLNLMVQQYFTNDQYHDLVDPAKHTYRIRSENSIFFEVDGPYLAMILPASKEMNKKLKKRYAVFNRDRSLAELKGFEVKRNGELNLIKIFQSSVFESFLKGSSISEVYQHVAIVANYWLDLLYSRASTMPDEELFELISEKRCMSKKLEEYGKQKSTSISTARRLAEFLGDEMVKDAGLSFKFIISKKPEGQQVTDRAIPVAIFQAEESVKRFYLSKWLKSKDLQ 3374
            +++ R +  D +D  +GFD       +TGWLINM  T+ +D++KR++SA+ YYF++EDGS+  F S+LIF         L  + E+ +YL KK+   +  +E++ KEDLDL NHL+GLK+ ++KL F+T+DDL++V++EI P +++N++ ++S ++Y+ ML+    G       E    KS +D +DN +D+REYDVPYHVR+SID  I +  WY+V    N        I  R D+V+ P+P+VLA+DIETTKLPLKFPDA  DQIMMISYMIDG G+LI NREI++++IEDFEFTP+PE+ GPF+VFNE NE   I+R+FDH++E KPNIFVTYNGDFFDWPFVETRA  HGL+M   IGF KD+Q EYKS  AIHMDC +WV+RDSYLP+G+  LKA  KAKL Y+PVE+DPEEMC++A E+P+TLA YSVSDAVATYYLYMKYVHPFIFALCTIIPM+PDEVLRKGSGTLCE LLMV+AF++NI+FPNKQE   N LT+DGHV++SETYVGGHVEA+ESGVFRSDIP +FK+ P    FL + ++ T+ H +E EEK+ ++ V NF+EV + I EKL  L+E   R ECP+IYHLDV AMYPNIIL+NRLQ +++  ++   A +                RG      +SE++ IQ QLE EK PP  P+ P R+F+ L++ EQA  EK+RL  +C+ AY + H TR E+R   +CQREN+FYVDTVRAFRDRRY++K L KV KK+L    + ++GDA+E+KR   M +LY+SLQLAHKCILNSFYGYVMRKGARWYSMEMAGIVC TGA II  ARE+IEQIGRPLELDTDGIWC+LP +FP+ F  +T+N KK  ++ SYPGAMLN+MV++ FTNDQYH+LVDPA  TY  R+ENSIFFEVDGPYLAMILPASKE  KKLKKRYAVFN D SLAELKGFE+KR GEL LIKIFQSSVFE+FLKG+++ EVY  VA VA+YWLD+LYS+A+ MPD ELF+LISE R MS+KLE+YG+QKSTSISTA+RLAEFLGD+MVKDAGLS +++IS+KPEG  VT+RAIP+AIFQAE SVK+ +L KWLK    Q
Sbjct:   26 KRLERSQFTDDMDARFGFDRMKEPGEKTGWLINMHPTEILDEDKRMISAVDYYFIQEDGSRWPFPSSLIF--------ILLQKREVISYLSKKFQGKVAKLEMLPKEDLDLPNHLVGLKRNYIKLSFNTVDDLIKVKREIAPAVRKNREREQSHDEYTSMLSSALSGVGVTTADEDGMSKSIVDQLDNVVDMREYDVPYHVRLSIDLKIHVAHWYNVRYRSN---AYPLEIIRRDDLVERPDPVVLAFDIETTKLPLKFPDAESDQIMMISYMIDGQGFLITNREIVSENIEDFEFTPKPEYEGPFTVFNEDNEAALIQRWFDHVQETKPNIFVTYNGDFFDWPFVETRAAVHGLNMHREIGFQKDSQGEYKSSQAIHMDCLRWVKRDSYLPVGSHNLKAAAKAKLGYDPVELDPEEMCRMATEEPQTLATYSVSDAVATYYLYMKYVHPFIFALCTIIPMEPDEVLRKGSGTLCEALLMVQAFHANIVFPNKQEQAFNKLTDDGHVLDSETYVGGHVEALESGVFRSDIPCRFKMNPAAFDFLLQRVERTMRHAIEEEEKIPLEQVTNFNEVCDEIKEKLTSLKEVPNRIECPLIYHLDVGAMYPNIILTNRLQVNSVDLKEDGLAVE----------------RGN----HRSEFHRIQQQLESEKLPPLFPNGPPRAFHTLNREEQAKHEKKRLADYCKKAYKKTHVTRLEQRVTTICQRENSFYVDTVRAFRDRRYEFKGLHKVWKKKLS--AAQDSGDAAEVKRCKNMEILYESLQLAHKCILNSFYGYVMRKGARWYSMEMAGIVCYTGANIITQARELIEQIGRPLELDTDGIWCVLPNTFPENFVVKTSNEKKPKVTISYPGAMLNIMVKEGFTNDQYHELVDPASLTYNTRAENSIFFEVDGPYLAMILPASKEEGKKLKKRYAVFNEDGSLAELKGFEIKRRGELQLIKIFQSSVFEAFLKGTTLEEVYTSVAKVADYWLDVLYSKAANMPDAELFDLISENRSMSRKLEDYGEQKSTSISTAKRLAEFLGDQMVKDAGLSCRYVISRKPEGSPVTERAIPLAIFQAESSVKKHFLRKWLKMPTCQ 1088
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BLAST of DNA polymerase epsilon catalytic subunit vs. Ensembl Medaka
Match: ENSORLT00000046570.1 (pep primary_assembly:ASM223467v1:9:13294875:13297325:1 gene:ENSORLG00000028840.1 transcript:ENSORLT00000046570.1 gene_biotype:protein_coding transcript_biotype:protein_coding)

HSP 1 Score: 138.272 bits (347), Expect = 2.988e-34
Identity = 102/424 (24.06%), Postives = 194/424 (45.75%), Query Frame = 3 
Query: 5748 TVRNQDIFSQLDFQYVSGWDYLIWQDVSNYSGIKSDLESVTKEEHNSMVLEELSFVNMTNPSLSMGLSQSQNEDSFLTTEIADSSQIEMNWHLSRYLSPMSGVQLRLIEILQYFMLTNWKIVKDEYKLNRLAA---KNDVAEEAVNTGTILGSDASLYPSSVQRMEDFLQNEMGYKLYLLVSQL-KDVPRMHNAVPLTTXXXXXXXXXXXSNKTPPLLPLKNKVSLHPIVDLIKTTCHILALDTSARYYVNDWKRNMFKLINFDAYSDQAKWRSPYSSDQSMGDAFRSDLIITVPEVICDNCNVTRDLDLCRD--LYQVRIKNSWWFVCPTCDFPYDRNVIQETLIDQVRCICESNVMQDLKCTKCTNGILETSLAGTENCVKCGNAIQVTQNAASLKEKIKIYADIGKHYDLPYLHMMTSWML 7001
            ++ +++IF  L   +   W +L+W D SNY G+K  + S            ++ +   T         Q + ++          + IE NW++  YL   +  Q   + I+  ++   +  +K+E + N   A   K  V  +A      LG D +  P  +   ++++ +E+   ++ +  ++ K V    N                ++++  P+LP  +    +P ++ +K  C +L+LDT+    VN  KR++ +L++   +SD+A++R P +S               +PEVIC +CN  RDLDLC+D  + Q       WF C  C   Y+ + ++ +LI+ ++    S  +QDL C KC  G+ E ++       +C     +T +A S  E+I ++ +I  HY++ +L     W+L
Sbjct:   19 SIHSREIFHSLSISFSRCWQFLLWMDPSNYGGVKGKVSS------------DVLYGEKTR--------QGEEDEDGNEESDDVENLIESNWNIMHYLPQTASCQQYFLMIVSAYIAAVYHSMKEELRRNAPGATPVKRRVGSQASQQA--LG-DLTALPGMISFSQEYVASELTQNIFTITQKIQKKVAGTRNVT--------------QTSEMFPVLPGSHLPLNNPALEFVKYVCQVLSLDTNIVNQVNKLKRDLLRLVDVGEFSDEAQFRDPCNS-------------YILPEVICHHCNFCRDLDLCKDPSVAQDGAVVPQWF-CSNCQAQYETDSVEVSLIEALQKKLMSYTLQDLVCNKC-KGVKEANMPLY---CRCAGDFSLTFSAKSFSEQIMVFRNIASHYNMRFLEETIDWLL 387
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BLAST of DNA polymerase epsilon catalytic subunit vs. Planmine SMEST
Match: SMESG000044635.1 (SMESG000044635.1)

HSP 1 Score: 4749.11 bits (12317), Expect = 0.000e+0
Identity = 2317/2332 (99.36%), Postives = 2322/2332 (99.57%), Query Frame = 3 
Query:   24 MNTKNNQFKNPTEKENDVFEAIERNEEKILRLKKNDQIDLVYGFDLHSAIKIRTGWLINMKTTDAIDDNKRLVSAMSYYFLEEDGSKFKSTLIFQPYFYIVTKLGCESEIQTYLMKKYSACLHNIEIIEKEDLDLDNHXXXXXXXXXXXXXHTIDDLVRVRKEIMPKIKQNQKNQESDNDYSKMLTEHFQGEKKYEYNARKSALDIMDNAIDIREYDVPYHVRVSIDTAIFIGKWYDVHGSMNIKGPNSTHITPRSDIVDHPEPIVLAYDIETTKLPLKFPDATFDQIMMISYMIDGMGYLICNREIIADDIEDFEFTPRPEFPGPFSVFNEPNEKRTIERFFDHIREVKPNIFVTYNGDFFDWPFVETRAVKHGLDMLDYIGFSKDNQNEYKSRSAIHMDCFKWVQRDSYLPIGAQGLKAVCKAKLRYNPVEVDPEEMCKVAREDPRTLANYSVSDAVATYYLYMKYVHPFIFALCTIIPMDPDEVLRKGSGTLCECLLMVEAFNSNIIFPNKQESKLNPLTNDGHVIESETYVGGHVEAIESGVFRSDIPTKFKIVPEMCKFLRKNLKETLVHVLEVEEKVTVDSVLNFDEVYNAIDEKLEDLEETNIRFECPVIYHLDVAAMYPNIILSNRLQPSALVNEKTCGACDFNVPNAKCKRPMTWKWRGEIMPATKSEYYLIQNQLEKEKFPPKKPSLPMRSFYELDKLEQATVEKERLGKFCRNAYNRKHNTRFEERTAVVCQRENAFYVDTVRAFRDRRYQYKDLTKVSKKRLDELISSENGDASEIKRANGMLVLYDSLQLAHKCILNSFYGYVMRKGARWYSMEMAGIVCSTGAAIIKYAREMIEQIGRPLELDTDGIWCILPASFPQGFEFQTNNPKKRNISFSYPGAMLNLMVQQYFTNDQYHDLVDPAKHTYRIRSENSIFFEVDGPYLAMILPASKEMNKKLKKRYAVFNRDRSLAELKGFEVKRNGELNLIKIFQSSVFESFLKGSSISEVYQHVAIVANYWLDLLYSRASTMPDEELFELISEKRCMSKKLEEYGKQKSTSISTARRLAEFLGDEMVKDAGLSFKFIISKKPEGQQVTDRAIPVAIFQAEESVKRFYLSKWLKSKDLQDFDIRNILDWDYYINRFSSNIQKIITIPAALQEVPNPVPRVAHPDWLHKILMEKDNRFKQQRITDIFQTITPSQAAADKMKDIENCAPISKKKPTGVTSLKRARNKDTVDVYGVQLDMDNLPNHWRDILGDPVPKGNSKSQFIVWLEFHXXXXXXXXXXXDQSELSKENINPATVKRIKTVKKGIQSGISSFFTRSKQSILEDTWQIIQITDTNVSGIYRVWVLIGQEIHNMKLTVPRTFYVNTRIPKAPGENMYFKQVHKLLPRSRIVYHLYEYNLDETIFIKHRSDILSEFIRNEVEGIYELEVPLLLRVYAKLGCMCSIDRNHFTDQQLSNNPSSFLLNELKFRSTAQHPYLSPNSIKTTFLFQQKSNRNEIIGWFDPCNNRAHLCLVEQSKPNPDKFQANVVQSWFSREREAFLSLKENESLISVVPEHVQFEVSSHKFEISAFKAINKLLVAHRNEVTTPTFIATKSKMTINELYSNLPALQEYPLVPITINETDVSFNVLDWQRIAIKSALQNFVKYEKLLAEMLERARYLHIPVGNMSKFTNDYRGISDSYDLFYGRFLMKNNFIWWCNDKSEPDLGKKENQDRRMMLVDNDVLNGMIYRNKPGCYPTTCVQLEMTYFPINTIIAMHKVMEIDGTNERLFESMIVPAKTIDQAMIQSKCNAAKRNLNLTSNTMYDDVTAAGPAFKILRNVILQWLDDVRNYKNPVADEHLMGFYKWMKNSRSLFYDPALFKSLQKLMRMVFFKLIEQLNNLGVEVIYGTLNKIVLCTKRTDLMDALVHVEYATKTVRNQDIFSQLDFQYVSGWDYLIWQDVSNYSGIKSDLESVTKEEHNSMVLEELSFVNMTNPSLSMGLSQSQNEDSFLTTEIADSSQIEMNWHLSRYLSPMSGVQLRLIEILQYFMLTNWKIVKDEYKLNRLAAKNDVAEEAVNTGTILGSDASLYPSSVQRMEDFLQNEMGYKLYLLVSQLKDVPRMHNAVPLTTXXXXXXXXXXXSNKTPPLLPLKNKVSLHPIVDLIKTTCHILALDTSARYYVNDWKRNMFKLINFDAYSDQAKWRSPYSSDQSMGDAFRSDLIITVPEVICDNCNVTRDLDLCRDLYQVRIKNSWWFVCPTCDFPYDRNVIQETLIDQVRCICESNVMQDLKCTKCTNGILETSLAGTENCVKCGNAIQVTQNAASLKEKIKIYADIGKHYDLPYLHMMTSWMLQGEDLS 7019
            MNTKNNQFKNPTEKENDVFEAIERNEEKILRLKKNDQIDLVYGFDLHSAIKIRTGWLINMKTTDAIDDNKRLVSAMSYYFLEEDGSKFKSTLIFQPYFYIVTKLGCESEIQTYLMKKYSACLHNIEIIEKEDLDLDNHLIGLKKIFLKLIFHTIDDLVRVRKEIMPKIKQNQKNQESDNDYSKMLTEHFQGEKKYEYNARKSALDIMDNAIDIREYDVPYHVRVSIDTAIFIGKWYDVHGSMNIKGPNSTHITPRSDIVDHPEPIVLAYDIETTKLPLKFPDATFDQIMMISYMIDGMGYLICNREIIADDIEDFEFTPRPEFPGPFSVFNEPNEKRTIERFFDHIREVKPNIFVTYNGDFFDWPFVETRAVKHGLDMLDYIGFSKDNQNEYKSRSAIHMDCFKWVQRDSYLPIGAQGLKAVCKAKLRYNPVEVDPEEMCKVAREDPRTLANYSVSDAVATYYLYMKYVHPFIFALCTIIPMDPDEVLRKGSGTLCECLLMVEAFNSNIIFPNKQESKLNPLTNDGHVIESETYVGGHVEAIESGVFRSDIPTKFKIVPEMCKFLRKNLKETLVHVLEVEEKVTVDSVLNFDEVYNAIDEKLEDLEETNIRFECPVIYHLDVAAMYPNIILSNRLQPSALVNEKTCGACDFNVPNAKCKRPMTWKWRGEIMPATKSEYYLIQNQLEKEKFPPKKP LPMRSFYELDKLEQATVEKERLGKFCRNAYNRKHNTRFEERTAVVCQRENAFYVDTVRAFRDRRYQYKDLTKVSKKRLDELISSENGDASEIKRANGMLVLYDSLQLAHKCILNSFYGYVMRKGARWYSMEMAGIVCSTGAAIIKYAREMIEQIGRPLELDTDGIWCILPASFPQGFEFQTNNPKKRNISFSYPGAMLNLMVQQYFTNDQYHDLVDPAKHTYRIRSENSIFFEVDGPYLAMILPASKEMNKKLKKRYAVFNRDRSLAELKGFEVKRNGELNLIKIFQSSVFESFLKGSSISEVYQHVAIVANYWLDLLYSRAS+MPDEELFELISEKRCMSKKLEEYGKQKSTSISTARRLAEFLGDEMVKDAGLSFKFIISKKPEGQQVTDRAIPVAIFQAEESVKRFYLSKWLKSKDLQDFDIRNILDWDYYINRFSSNIQKIITIPAALQEVPNPVPRVAHPDWLHKILMEKDNRFKQQRITD+FQTITPSQAAADKMKDIENCAPISKKKPT VTSLKRARN DTVDVYGVQLDMDNLPNHWRDILGDPVPKGN+KSQFIVWLEFHKKKWKIQKIIK QSELSKENINPATVKRIKTVKKGIQSGISSFFTRSKQSILEDTWQIIQITDTNVSG YRVWVLIGQEIHNMKLTVPRTFYVNTRIPKAPGENMYFKQVHKLLPRSRIVYHLYEYNLDETIFIKHRSDILSEFIRNEVEGIYELEVPLLLRVYAKLGCMCSIDRNHFTDQQLSNNPSSFLLNELKFRSTAQHPYLSPNSIKTTFLFQ KSNRNEIIGWFDPCNNRAHLCLVEQSKPNPDKFQANVVQSWFSREREAFLSLKENESLISVVPEHVQFEVSSHKFEISAFKAINKLLVAHRNEVTTPTFIATKSKMTINELYSNLPALQEYPLVPITI ETDVSFNVLDWQRIAIKSALQNFVKYEKLLAEMLERARYLHIPVGNMSKFTNDYRGISDSYDLFYGRFLMKNNFIWWCNDKSEPDLGKKENQDRRMMLVDND LNGMIYRNKPGCYPTTCVQLEMTYFPINTIIAMHKVMEIDGTNERLFESMIVPAKTIDQAMIQSKCNAAKRN+NLTSNTMYDDVTAAGPAFKILRNVILQWLDDVRNYKNPVADEHLMGFYKWMKNSRSLFYDPALFKSLQKLMRMVFFKLIEQLNNLGVEVIYGTLNKIVLCTKRTDLMDALVHVEYATKTVRNQDIFSQLDFQYVSGWDYLIWQDVSNYSGIKSDLESVTKEEHNSMVLEELSFVNMTNPSLSMGLSQSQNEDSFLTTEIADSSQIEMNWHLSRYLSPMSGVQLRLIEILQYFMLTNWKIVKDEYKLNRLAAKNDVAEEAVNTGTILGSDASLYPSSVQRMEDFLQNEMGYKLYLLVSQLKDVPRMHNAVPLTT DDDDKEG+DESNKTPPLLPLKNKVSLHPIVDLIKTTCHILALDTSARYYVNDWKRNMFKLINFDAYSDQAKWRSPYSSDQSMGDAFRSDLIITVPEVICDNCNVTRDLDLCRDLYQVRIKNSWWFVCPTCDFPYDRNVIQETLIDQVRCICESNVMQDLKCTKCTNGILETSLAGTENCVKCGNAIQVTQNAASLKEKIKIYADIGKHYDLPYLHMMTSWML GEDLS
Sbjct:    1 MNTKNNQFKNPTEKENDVFEAIERNEEKILRLKKNDQIDLVYGFDLHSAIKIRTGWLINMKTTDAIDDNKRLVSAMSYYFLEEDGSKFKSTLIFQPYFYIVTKLGCESEIQTYLMKKYSACLHNIEIIEKEDLDLDNHLIGLKKIFLKLIFHTIDDLVRVRKEIMPKIKQNQKNQESDNDYSKMLTEHFQGEKKYEYNARKSALDIMDNAIDIREYDVPYHVRVSIDTAIFIGKWYDVHGSMNIKGPNSTHITPRSDIVDHPEPIVLAYDIETTKLPLKFPDATFDQIMMISYMIDGMGYLICNREIIADDIEDFEFTPRPEFPGPFSVFNEPNEKRTIERFFDHIREVKPNIFVTYNGDFFDWPFVETRAVKHGLDMLDYIGFSKDNQNEYKSRSAIHMDCFKWVQRDSYLPIGAQGLKAVCKAKLRYNPVEVDPEEMCKVAREDPRTLANYSVSDAVATYYLYMKYVHPFIFALCTIIPMDPDEVLRKGSGTLCECLLMVEAFNSNIIFPNKQESKLNPLTNDGHVIESETYVGGHVEAIESGVFRSDIPTKFKIVPEMCKFLRKNLKETLVHVLEVEEKVTVDSVLNFDEVYNAIDEKLEDLEETNIRFECPVIYHLDVAAMYPNIILSNRLQPSALVNEKTCGACDFNVPNAKCKRPMTWKWRGEIMPATKSEYYLIQNQLEKEKFPPKKPGLPMRSFYELDKLEQATVEKERLGKFCRNAYNRKHNTRFEERTAVVCQRENAFYVDTVRAFRDRRYQYKDLTKVSKKRLDELISSENGDASEIKRANGMLVLYDSLQLAHKCILNSFYGYVMRKGARWYSMEMAGIVCSTGAAIIKYAREMIEQIGRPLELDTDGIWCILPASFPQGFEFQTNNPKKRNISFSYPGAMLNLMVQQYFTNDQYHDLVDPAKHTYRIRSENSIFFEVDGPYLAMILPASKEMNKKLKKRYAVFNRDRSLAELKGFEVKRNGELNLIKIFQSSVFESFLKGSSISEVYQHVAIVANYWLDLLYSRASSMPDEELFELISEKRCMSKKLEEYGKQKSTSISTARRLAEFLGDEMVKDAGLSFKFIISKKPEGQQVTDRAIPVAIFQAEESVKRFYLSKWLKSKDLQDFDIRNILDWDYYINRFSSNIQKIITIPAALQEVPNPVPRVAHPDWLHKILMEKDNRFKQQRITDMFQTITPSQAAADKMKDIENCAPISKKKPTEVTSLKRARNNDTVDVYGVQLDMDNLPNHWRDILGDPVPKGNNKSQFIVWLEFHKKKWKIQKIIKHQSELSKENINPATVKRIKTVKKGIQSGISSFFTRSKQSILEDTWQIIQITDTNVSGTYRVWVLIGQEIHNMKLTVPRTFYVNTRIPKAPGENMYFKQVHKLLPRSRIVYHLYEYNLDETIFIKHRSDILSEFIRNEVEGIYELEVPLLLRVYAKLGCMCSIDRNHFTDQQLSNNPSSFLLNELKFRSTAQHPYLSPNSIKTTFLFQHKSNRNEIIGWFDPCNNRAHLCLVEQSKPNPDKFQANVVQSWFSREREAFLSLKENESLISVVPEHVQFEVSSHKFEISAFKAINKLLVAHRNEVTTPTFIATKSKMTINELYSNLPALQEYPLVPITIGETDVSFNVLDWQRIAIKSALQNFVKYEKLLAEMLERARYLHIPVGNMSKFTNDYRGISDSYDLFYGRFLMKNNFIWWCNDKSEPDLGKKENQDRRMMLVDNDALNGMIYRNKPGCYPTTCVQLEMTYFPINTIIAMHKVMEIDGTNERLFESMIVPAKTIDQAMIQSKCNAAKRNMNLTSNTMYDDVTAAGPAFKILRNVILQWLDDVRNYKNPVADEHLMGFYKWMKNSRSLFYDPALFKSLQKLMRMVFFKLIEQLNNLGVEVIYGTLNKIVLCTKRTDLMDALVHVEYATKTVRNQDIFSQLDFQYVSGWDYLIWQDVSNYSGIKSDLESVTKEEHNSMVLEELSFVNMTNPSLSMGLSQSQNEDSFLTTEIADSSQIEMNWHLSRYLSPMSGVQLRLIEILQYFMLTNWKIVKDEYKLNRLAAKNDVAEEAVNTGTILGSDASLYPSSVQRMEDFLQNEMGYKLYLLVSQLKDVPRMHNAVPLTT-DDDDKEGDDESNKTPPLLPLKNKVSLHPIVDLIKTTCHILALDTSARYYVNDWKRNMFKLINFDAYSDQAKWRSPYSSDQSMGDAFRSDLIITVPEVICDNCNVTRDLDLCRDLYQVRIKNSWWFVCPTCDFPYDRNVIQETLIDQVRCICESNVMQDLKCTKCTNGILETSLAGTENCVKCGNAIQVTQNAASLKEKIKIYADIGKHYDLPYLHMMTSWMLLGEDLS 2331
[Close]
BLAST of DNA polymerase epsilon catalytic subunit vs. Planmine SMEST
Match: SMESG000044635.1 (SMESG000044635.1)

HSP 1 Score: 4744.87 bits (12306), Expect = 0.000e+0
Identity = 2313/2328 (99.36%), Postives = 2318/2328 (99.57%), Query Frame = 3 
Query:   36 NNQFKNPTEKENDVFEAIERNEEKILRLKKNDQIDLVYGFDLHSAIKIRTGWLINMKTTDAIDDNKRLVSAMSYYFLEEDGSKFKSTLIFQPYFYIVTKLGCESEIQTYLMKKYSACLHNIEIIEKEDLDLDNHXXXXXXXXXXXXXHTIDDLVRVRKEIMPKIKQNQKNQESDNDYSKMLTEHFQGEKKYEYNARKSALDIMDNAIDIREYDVPYHVRVSIDTAIFIGKWYDVHGSMNIKGPNSTHITPRSDIVDHPEPIVLAYDIETTKLPLKFPDATFDQIMMISYMIDGMGYLICNREIIADDIEDFEFTPRPEFPGPFSVFNEPNEKRTIERFFDHIREVKPNIFVTYNGDFFDWPFVETRAVKHGLDMLDYIGFSKDNQNEYKSRSAIHMDCFKWVQRDSYLPIGAQGLKAVCKAKLRYNPVEVDPEEMCKVAREDPRTLANYSVSDAVATYYLYMKYVHPFIFALCTIIPMDPDEVLRKGSGTLCECLLMVEAFNSNIIFPNKQESKLNPLTNDGHVIESETYVGGHVEAIESGVFRSDIPTKFKIVPEMCKFLRKNLKETLVHVLEVEEKVTVDSVLNFDEVYNAIDEKLEDLEETNIRFECPVIYHLDVAAMYPNIILSNRLQPSALVNEKTCGACDFNVPNAKCKRPMTWKWRGEIMPATKSEYYLIQNQLEKEKFPPKKPSLPMRSFYELDKLEQATVEKERLGKFCRNAYNRKHNTRFEERTAVVCQRENAFYVDTVRAFRDRRYQYKDLTKVSKKRLDELISSENGDASEIKRANGMLVLYDSLQLAHKCILNSFYGYVMRKGARWYSMEMAGIVCSTGAAIIKYAREMIEQIGRPLELDTDGIWCILPASFPQGFEFQTNNPKKRNISFSYPGAMLNLMVQQYFTNDQYHDLVDPAKHTYRIRSENSIFFEVDGPYLAMILPASKEMNKKLKKRYAVFNRDRSLAELKGFEVKRNGELNLIKIFQSSVFESFLKGSSISEVYQHVAIVANYWLDLLYSRASTMPDEELFELISEKRCMSKKLEEYGKQKSTSISTARRLAEFLGDEMVKDAGLSFKFIISKKPEGQQVTDRAIPVAIFQAEESVKRFYLSKWLKSKDLQDFDIRNILDWDYYINRFSSNIQKIITIPAALQEVPNPVPRVAHPDWLHKILMEKDNRFKQQRITDIFQTITPSQAAADKMKDIENCAPISKKKPTGVTSLKRARNKDTVDVYGVQLDMDNLPNHWRDILGDPVPKGNSKSQFIVWLEFHXXXXXXXXXXXDQSELSKENINPATVKRIKTVKKGIQSGISSFFTRSKQSILEDTWQIIQITDTNVSGIYRVWVLIGQEIHNMKLTVPRTFYVNTRIPKAPGENMYFKQVHKLLPRSRIVYHLYEYNLDETIFIKHRSDILSEFIRNEVEGIYELEVPLLLRVYAKLGCMCSIDRNHFTDQQLSNNPSSFLLNELKFRSTAQHPYLSPNSIKTTFLFQQKSNRNEIIGWFDPCNNRAHLCLVEQSKPNPDKFQANVVQSWFSREREAFLSLKENESLISVVPEHVQFEVSSHKFEISAFKAINKLLVAHRNEVTTPTFIATKSKMTINELYSNLPALQEYPLVPITINETDVSFNVLDWQRIAIKSALQNFVKYEKLLAEMLERARYLHIPVGNMSKFTNDYRGISDSYDLFYGRFLMKNNFIWWCNDKSEPDLGKKENQDRRMMLVDNDVLNGMIYRNKPGCYPTTCVQLEMTYFPINTIIAMHKVMEIDGTNERLFESMIVPAKTIDQAMIQSKCNAAKRNLNLTSNTMYDDVTAAGPAFKILRNVILQWLDDVRNYKNPVADEHLMGFYKWMKNSRSLFYDPALFKSLQKLMRMVFFKLIEQLNNLGVEVIYGTLNKIVLCTKRTDLMDALVHVEYATKTVRNQDIFSQLDFQYVSGWDYLIWQDVSNYSGIKSDLESVTKEEHNSMVLEELSFVNMTNPSLSMGLSQSQNEDSFLTTEIADSSQIEMNWHLSRYLSPMSGVQLRLIEILQYFMLTNWKIVKDEYKLNRLAAKNDVAEEAVNTGTILGSDASLYPSSVQRMEDFLQNEMGYKLYLLVSQLKDVPRMHNAVPLTTXXXXXXXXXXXSNKTPPLLPLKNKVSLHPIVDLIKTTCHILALDTSARYYVNDWKRNMFKLINFDAYSDQAKWRSPYSSDQSMGDAFRSDLIITVPEVICDNCNVTRDLDLCRDLYQVRIKNSWWFVCPTCDFPYDRNVIQETLIDQVRCICESNVMQDLKCTKCTNGILETSLAGTENCVKCGNAIQVTQNAASLKEKIKIYADIGKHYDLPYLHMMTSWMLQGEDLS 7019
            NNQFKNPTEKENDVFEAIERNEEKILRLKKNDQIDLVYGFDLHSAIKIRTGWLINMKTTDAIDDNKRLVSAMSYYFLEEDGSKFKSTLIFQPYFYIVTKLGCESEIQTYLMKKYSACLHNIEIIEKEDLDLDNHLIGLKKIFLKLIFHTIDDLVRVRKEIMPKIKQNQKNQESDNDYSKMLTEHFQGEKKYEYNARKSALDIMDNAIDIREYDVPYHVRVSIDTAIFIGKWYDVHGSMNIKGPNSTHITPRSDIVDHPEPIVLAYDIETTKLPLKFPDATFDQIMMISYMIDGMGYLICNREIIADDIEDFEFTPRPEFPGPFSVFNEPNEKRTIERFFDHIREVKPNIFVTYNGDFFDWPFVETRAVKHGLDMLDYIGFSKDNQNEYKSRSAIHMDCFKWVQRDSYLPIGAQGLKAVCKAKLRYNPVEVDPEEMCKVAREDPRTLANYSVSDAVATYYLYMKYVHPFIFALCTIIPMDPDEVLRKGSGTLCECLLMVEAFNSNIIFPNKQESKLNPLTNDGHVIESETYVGGHVEAIESGVFRSDIPTKFKIVPEMCKFLRKNLKETLVHVLEVEEKVTVDSVLNFDEVYNAIDEKLEDLEETNIRFECPVIYHLDVAAMYPNIILSNRLQPSALVNEKTCGACDFNVPNAKCKRPMTWKWRGEIMPATKSEYYLIQNQLEKEKFPPKKP LPMRSFYELDKLEQATVEKERLGKFCRNAYNRKHNTRFEERTAVVCQRENAFYVDTVRAFRDRRYQYKDLTKVSKKRLDELISSENGDASEIKRANGMLVLYDSLQLAHKCILNSFYGYVMRKGARWYSMEMAGIVCSTGAAIIKYAREMIEQIGRPLELDTDGIWCILPASFPQGFEFQTNNPKKRNISFSYPGAMLNLMVQQYFTNDQYHDLVDPAKHTYRIRSENSIFFEVDGPYLAMILPASKEMNKKLKKRYAVFNRDRSLAELKGFEVKRNGELNLIKIFQSSVFESFLKGSSISEVYQHVAIVANYWLDLLYSRAS+MPDEELFELISEKRCMSKKLEEYGKQKSTSISTARRLAEFLGDEMVKDAGLSFKFIISKKPEGQQVTDRAIPVAIFQAEESVKRFYLSKWLKSKDLQDFDIRNILDWDYYINRFSSNIQKIITIPAALQEVPNPVPRVAHPDWLHKILMEKDNRFKQQRITD+FQTITPSQAAADKMKDIENCAPISKKKPT VTSLKRARN DTVDVYGVQLDMDNLPNHWRDILGDPVPKGN+KSQFIVWLEFHKKKWKIQKIIK QSELSKENINPATVKRIKTVKKGIQSGISSFFTRSKQSILEDTWQIIQITDTNVSG YRVWVLIGQEIHNMKLTVPRTFYVNTRIPKAPGENMYFKQVHKLLPRSRIVYHLYEYNLDETIFIKHRSDILSEFIRNEVEGIYELEVPLLLRVYAKLGCMCSIDRNHFTDQQLSNNPSSFLLNELKFRSTAQHPYLSPNSIKTTFLFQ KSNRNEIIGWFDPCNNRAHLCLVEQSKPNPDKFQANVVQSWFSREREAFLSLKENESLISVVPEHVQFEVSSHKFEISAFKAINKLLVAHRNEVTTPTFIATKSKMTINELYSNLPALQEYPLVPITI ETDVSFNVLDWQRIAIKSALQNFVKYEKLLAEMLERARYLHIPVGNMSKFTNDYRGISDSYDLFYGRFLMKNNFIWWCNDKSEPDLGKKENQDRRMMLVDND LNGMIYRNKPGCYPTTCVQLEMTYFPINTIIAMHKVMEIDGTNERLFESMIVPAKTIDQAMIQSKCNAAKRN+NLTSNTMYDDVTAAGPAFKILRNVILQWLDDVRNYKNPVADEHLMGFYKWMKNSRSLFYDPALFKSLQKLMRMVFFKLIEQLNNLGVEVIYGTLNKIVLCTKRTDLMDALVHVEYATKTVRNQDIFSQLDFQYVSGWDYLIWQDVSNYSGIKSDLESVTKEEHNSMVLEELSFVNMTNPSLSMGLSQSQNEDSFLTTEIADSSQIEMNWHLSRYLSPMSGVQLRLIEILQYFMLTNWKIVKDEYKLNRLAAKNDVAEEAVNTGTILGSDASLYPSSVQRMEDFLQNEMGYKLYLLVSQLKDVPRMHNAVPLTT DDDDKEG+DESNKTPPLLPLKNKVSLHPIVDLIKTTCHILALDTSARYYVNDWKRNMFKLINFDAYSDQAKWRSPYSSDQSMGDAFRSDLIITVPEVICDNCNVTRDLDLCRDLYQVRIKNSWWFVCPTCDFPYDRNVIQETLIDQVRCICESNVMQDLKCTKCTNGILETSLAGTENCVKCGNAIQVTQNAASLKEKIKIYADIGKHYDLPYLHMMTSWML GEDLS
Sbjct:   25 NNQFKNPTEKENDVFEAIERNEEKILRLKKNDQIDLVYGFDLHSAIKIRTGWLINMKTTDAIDDNKRLVSAMSYYFLEEDGSKFKSTLIFQPYFYIVTKLGCESEIQTYLMKKYSACLHNIEIIEKEDLDLDNHLIGLKKIFLKLIFHTIDDLVRVRKEIMPKIKQNQKNQESDNDYSKMLTEHFQGEKKYEYNARKSALDIMDNAIDIREYDVPYHVRVSIDTAIFIGKWYDVHGSMNIKGPNSTHITPRSDIVDHPEPIVLAYDIETTKLPLKFPDATFDQIMMISYMIDGMGYLICNREIIADDIEDFEFTPRPEFPGPFSVFNEPNEKRTIERFFDHIREVKPNIFVTYNGDFFDWPFVETRAVKHGLDMLDYIGFSKDNQNEYKSRSAIHMDCFKWVQRDSYLPIGAQGLKAVCKAKLRYNPVEVDPEEMCKVAREDPRTLANYSVSDAVATYYLYMKYVHPFIFALCTIIPMDPDEVLRKGSGTLCECLLMVEAFNSNIIFPNKQESKLNPLTNDGHVIESETYVGGHVEAIESGVFRSDIPTKFKIVPEMCKFLRKNLKETLVHVLEVEEKVTVDSVLNFDEVYNAIDEKLEDLEETNIRFECPVIYHLDVAAMYPNIILSNRLQPSALVNEKTCGACDFNVPNAKCKRPMTWKWRGEIMPATKSEYYLIQNQLEKEKFPPKKPGLPMRSFYELDKLEQATVEKERLGKFCRNAYNRKHNTRFEERTAVVCQRENAFYVDTVRAFRDRRYQYKDLTKVSKKRLDELISSENGDASEIKRANGMLVLYDSLQLAHKCILNSFYGYVMRKGARWYSMEMAGIVCSTGAAIIKYAREMIEQIGRPLELDTDGIWCILPASFPQGFEFQTNNPKKRNISFSYPGAMLNLMVQQYFTNDQYHDLVDPAKHTYRIRSENSIFFEVDGPYLAMILPASKEMNKKLKKRYAVFNRDRSLAELKGFEVKRNGELNLIKIFQSSVFESFLKGSSISEVYQHVAIVANYWLDLLYSRASSMPDEELFELISEKRCMSKKLEEYGKQKSTSISTARRLAEFLGDEMVKDAGLSFKFIISKKPEGQQVTDRAIPVAIFQAEESVKRFYLSKWLKSKDLQDFDIRNILDWDYYINRFSSNIQKIITIPAALQEVPNPVPRVAHPDWLHKILMEKDNRFKQQRITDMFQTITPSQAAADKMKDIENCAPISKKKPTEVTSLKRARNNDTVDVYGVQLDMDNLPNHWRDILGDPVPKGNNKSQFIVWLEFHKKKWKIQKIIKHQSELSKENINPATVKRIKTVKKGIQSGISSFFTRSKQSILEDTWQIIQITDTNVSGTYRVWVLIGQEIHNMKLTVPRTFYVNTRIPKAPGENMYFKQVHKLLPRSRIVYHLYEYNLDETIFIKHRSDILSEFIRNEVEGIYELEVPLLLRVYAKLGCMCSIDRNHFTDQQLSNNPSSFLLNELKFRSTAQHPYLSPNSIKTTFLFQHKSNRNEIIGWFDPCNNRAHLCLVEQSKPNPDKFQANVVQSWFSREREAFLSLKENESLISVVPEHVQFEVSSHKFEISAFKAINKLLVAHRNEVTTPTFIATKSKMTINELYSNLPALQEYPLVPITIGETDVSFNVLDWQRIAIKSALQNFVKYEKLLAEMLERARYLHIPVGNMSKFTNDYRGISDSYDLFYGRFLMKNNFIWWCNDKSEPDLGKKENQDRRMMLVDNDALNGMIYRNKPGCYPTTCVQLEMTYFPINTIIAMHKVMEIDGTNERLFESMIVPAKTIDQAMIQSKCNAAKRNMNLTSNTMYDDVTAAGPAFKILRNVILQWLDDVRNYKNPVADEHLMGFYKWMKNSRSLFYDPALFKSLQKLMRMVFFKLIEQLNNLGVEVIYGTLNKIVLCTKRTDLMDALVHVEYATKTVRNQDIFSQLDFQYVSGWDYLIWQDVSNYSGIKSDLESVTKEEHNSMVLEELSFVNMTNPSLSMGLSQSQNEDSFLTTEIADSSQIEMNWHLSRYLSPMSGVQLRLIEILQYFMLTNWKIVKDEYKLNRLAAKNDVAEEAVNTGTILGSDASLYPSSVQRMEDFLQNEMGYKLYLLVSQLKDVPRMHNAVPLTT-DDDDKEGDDESNKTPPLLPLKNKVSLHPIVDLIKTTCHILALDTSARYYVNDWKRNMFKLINFDAYSDQAKWRSPYSSDQSMGDAFRSDLIITVPEVICDNCNVTRDLDLCRDLYQVRIKNSWWFVCPTCDFPYDRNVIQETLIDQVRCICESNVMQDLKCTKCTNGILETSLAGTENCVKCGNAIQVTQNAASLKEKIKIYADIGKHYDLPYLHMMTSWMLLGEDLS 2351
[Close]
BLAST of DNA polymerase epsilon catalytic subunit vs. Planmine SMEST
Match: SMESG000030246.1 (SMESG000030246.1)

HSP 1 Score: 604.749 bits (1558), Expect = 0.000e+0
Identity = 299/325 (92.00%), Postives = 308/325 (94.77%), Query Frame = 3 
Query: 6045 MSGVQLRLIEILQYFMLTNWKIVKDEYKLNRLAAKNDVAEEAVNTGTILGSDASLYPSSVQRMEDFLQNEMGYKLYLLVSQLKDVPRMHNAVPLTTXXXXXXXXXXXSNKTPPLLPLKNKVSLHPIVDLIKTTCHILALDTSARYYVNDWKRNMFKLINFDAYSDQAKWRSPYSSDQSMGDAFRSDLIITVPEVICDNCNVTRDLDLCRDLYQVRIKNSWWFVCPTCDFPYDRNVIQETLIDQVRCICESNVMQDLKCTKCTNGILETSLAGTENCVKCGNAIQVTQNAASLKEKIKIYADIGKHYDLPYLHMMTSWMLQGEDLS 7019
            MSGVQLRLIEILQYFML NWKIVKDEYKLNRL+AKNDVAEEA+N GTILGSDASLYPSSVQRMEDFLQNEMGYKLYLLVSQLKDVP MH+AVPLTTDDDDDKE +D SNKTPPLLPLKNKVSLHPIVDLIKT  HILALDT ARYYVNDWKRNMFKLINFDAYSDQAKWRSPYSSDQS  DAF+SDLIITVPEVICDNCNVTRDLDLC+DLYQ+RIKNSWWFVCPTCDFPYDRNVIQETLIDQVRCIC SN MQ+LKCTKCTNGILETS AGTENCVK GNAIQVTQNA SLKEKIKIYADIGKHYDLPYL+MM SWMLQGE LS
Sbjct:    1 MSGVQLRLIEILQYFMLANWKIVKDEYKLNRLSAKNDVAEEALNNGTILGSDASLYPSSVQRMEDFLQNEMGYKLYLLVSQLKDVPPMHHAVPLTTDDDDDKECDDVSNKTPPLLPLKNKVSLHPIVDLIKTMRHILALDTFARYYVNDWKRNMFKLINFDAYSDQAKWRSPYSSDQSTADAFKSDLIITVPEVICDNCNVTRDLDLCKDLYQMRIKNSWWFVCPTCDFPYDRNVIQETLIDQVRCICGSNEMQNLKCTKCTNGILETSFAGTENCVKFGNAIQVTQNATSLKEKIKIYADIGKHYDLPYLYMMASWMLQGEHLS 325
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BLAST of DNA polymerase epsilon catalytic subunit vs. Planmine SMEST
Match: SMESG000044742.1 (SMESG000044742.1)

HSP 1 Score: 510.375 bits (1313), Expect = 8.000e-166
Identity = 258/302 (85.43%), Postives = 270/302 (89.40%), Query Frame = 3 
Query: 3537 DNRFKQQRITDIFQTITPSQAAADKMKDIENCAPISKKKPTGVTSLKRARNKDTVDVYGVQLDMDNLPNHWRDILGDPVPKGNSKSQFIVWLEFHXXXXXXXXXXXDQSELSKENINPATVKRIKTVKKGIQSGISSFFTRSKQSILEDTWQIIQITDTNVSGIYRVWVLIGQEIHNMKLTVPRTFYVNTRIPKAPGENMYFKQVHKLLPRSRIVYHLYEYNLDETIFIKHRSDILSEFIRNEVEGIYELEVPLLLRVYAKLGCMCSIDRNHFTDQQLSNNPSSFLLNELKFRSTAQHPYLS 4442
            D    QQRITD+FQTITPSQ+AADKMKDIENCAPISKKKPTGVTSLKRARNKDTVDVYGVQLDMDNLPNH+RD+LG+ VPKGNSKSQ + W EFH+KKWKIQKI  DQSE SK               K IQSGISSFFTRSKQSILEDTWQIIQITDT+VSG YRV  LIGQ++HN+KLTVPRTFYVNTRIPKAPGENMYFKQV+KLLPRSRIVYHLYEYNLDETIFIKHRSDILSEFIRNEVEGIYELEVPLLLRVYAKLG MCSIDRNHFTDQQL NNPSSFLLNELKFRSTAQHPYLS
Sbjct:  181 DEMIMQQRITDLFQTITPSQSAADKMKDIENCAPISKKKPTGVTSLKRARNKDTVDVYGVQLDMDNLPNHYRDVLGNLVPKGNSKSQSLAWPEFHEKKWKIQKIFNDQSEFSK---------------KIIQSGISSFFTRSKQSILEDTWQIIQITDTDVSGTYRVLALIGQKMHNIKLTVPRTFYVNTRIPKAPGENMYFKQVYKLLPRSRIVYHLYEYNLDETIFIKHRSDILSEFIRNEVEGIYELEVPLLLRVYAKLGYMCSIDRNHFTDQQLQNNPSSFLLNELKFRSTAQHPYLS 467

HSP 2 Score: 96.2857 bits (238), Expect = 8.000e-166
Identity = 49/62 (79.03%), Postives = 54/62 (87.10%), Query Frame = 1 
Query: 4447 IQSKPPFYSNRNPTETKLSAGLIRVTTELIFV*LNNLNRIPINSKRMLSNLGSQEKGKLFYH 4632
            + SK PFYS+ + TETKLSAG+IRVTTELIFV LNN NRIPINSK MLSNLGSQ+K KLFYH
Sbjct:  466 LSSKQPFYSSISQTETKLSAGMIRVTTELIFVSLNNQNRIPINSKLMLSNLGSQKKEKLFYH 527

HSP 3 Score: 122.094 bits (305), Expect = 4.084e-28
Identity = 56/66 (84.85%), Postives = 62/66 (93.94%), Query Frame = 3 
Query: 3024 QHVAIVANYWLDLLYSRASTMPDEELFELISEKRCMSKKLEEYGKQKSTSISTARRLAEFLGDEMV 3221
            QHVA  ANYWLDLLYS+AS MPD+ELFELISEKRCMS KLEEYGKQKSTSISTA+R++EFLGDEM+
Sbjct:  119 QHVASNANYWLDLLYSKASIMPDDELFELISEKRCMSTKLEEYGKQKSTSISTAKRISEFLGDEMI 184
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BLAST of DNA polymerase epsilon catalytic subunit vs. Planmine SMEST
Match: SMESG000044744.1 (SMESG000044744.1)

HSP 1 Score: 479.559 bits (1233), Expect = 7.664e-155
Identity = 238/263 (90.49%), Postives = 243/263 (92.40%), Query Frame = 3 
Query: 6231 MEDFLQNEMGYKLYLLVSQLKDVPRMHNAVPLTTXXXXXXXXXXXSNKTPPLLPLKNKVSLHPIVDLIKTTCHILALDTSARYYVNDWKRNMFKLINFDAYSDQAKWRSPYSSDQSMGDAFRSDLIITVPEVICDNCNVTRDLDLCRDLYQVRIKNSWWFVCPTCDFPYDRNVIQETLIDQVRCICESNVMQDLKCTKCTNGILETSLAGTENCVKCGNAIQVTQNAASLKEKIKIYADIGKHYDLPYLHMMTSWMLQGEDLS 7019
            MEDFLQNEM YKLYLLVSQLKDV  MH+AVPLTTD+DDDKE +D SNKTPPLLPLKNKVSLHPIVDLIKT  HILALDTSARYYVNDWKRNMF  INFDAY DQAKWRSPYSSDQS  DAF+SDLIITVPEVICDNCNVTRDLDLCRDLYQVRIKN WWFVCPTCDF YDRNVIQETLIDQVRCICESN MQ+LKCTKCTNGILETSLAGTENCVKCGNAIQVTQNA SLKEKIK YADIGKHYDLPYLH M SWMLQGE LS
Sbjct:    1 MEDFLQNEMRYKLYLLVSQLKDVSPMHHAVPLTTDNDDDKECDDVSNKTPPLLPLKNKVSLHPIVDLIKTMRHILALDTSARYYVNDWKRNMFNFINFDAYFDQAKWRSPYSSDQSTADAFKSDLIITVPEVICDNCNVTRDLDLCRDLYQVRIKNRWWFVCPTCDFRYDRNVIQETLIDQVRCICESNEMQNLKCTKCTNGILETSLAGTENCVKCGNAIQVTQNATSLKEKIKKYADIGKHYDLPYLHTMASWMLQGEHLS 263
The following BLAST results are available for this feature:
BLAST of DNA polymerase epsilon catalytic subunit vs. Ensembl Human
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Human e!99)
Total hits: 5
Match NameE-valueIdentityDescription
POLE0.000e+046.97DNA polymerase epsilon, catalytic subunit [Source:... [more]
POLE0.000e+046.32DNA polymerase epsilon, catalytic subunit [Source:... [more]
POLE8.930e-15578.04DNA polymerase epsilon, catalytic subunit [Source:... [more]
POLE1.294e-7648.73DNA polymerase epsilon, catalytic subunit [Source:... [more]
POLE6.066e-3945.00DNA polymerase epsilon, catalytic subunit [Source:... [more]
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BLAST of DNA polymerase epsilon catalytic subunit vs. Ensembl Celegans
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99)
Total hits: 1
Match NameE-valueIdentityDescription
pole-10.000e+042.44DNA polymerase epsilon catalytic subunit [Source:... [more]
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BLAST of DNA polymerase epsilon catalytic subunit vs. Ensembl Fly
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99)
Total hits: 1
Match NameE-valueIdentityDescription
DNApol-epsilon2557.770e-1746.52gene:FBgn0264326 transcript:FBtr0084408[more]
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BLAST of DNA polymerase epsilon catalytic subunit vs. Ensembl Zebrafish
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99)
Total hits: 2
Match NameE-valueIdentityDescription
pole0.000e+046.39polymerase (DNA directed), epsilon [Source:ZFIN;Ac... [more]
pole0.000e+045.65polymerase (DNA directed), epsilon [Source:ZFIN;Ac... [more]
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BLAST of DNA polymerase epsilon catalytic subunit vs. Ensembl Xenopus
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99)
Total hits: 5
Match NameE-valueIdentityDescription
prmt80.000e+046.72protein arginine methyltransferase 8 [Source:Xenba... [more]
prmt80.000e+046.72protein arginine methyltransferase 8 [Source:Xenba... [more]
prmt80.000e+046.77protein arginine methyltransferase 8 [Source:Xenba... [more]
prmt80.000e+047.17protein arginine methyltransferase 8 [Source:Xenba... [more]
prmt80.000e+046.08protein arginine methyltransferase 8 [Source:Xenba... [more]
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BLAST of DNA polymerase epsilon catalytic subunit vs. Ensembl Mouse
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99)
Total hits: 3
Match NameE-valueIdentityDescription
Pole0.000e+047.03polymerase (DNA directed), epsilon [Source:MGI Sym... [more]
Pole1.058e-3946.25polymerase (DNA directed), epsilon [Source:MGI Sym... [more]
Pole1.047e-3424.83polymerase (DNA directed), epsilon [Source:MGI Sym... [more]
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BLAST of DNA polymerase epsilon catalytic subunit vs. UniProt/SwissProt
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt)
Total hits: 5
Match NameE-valueIdentityDescription
sp|Q07864|DPOE1_HUMAN0.000e+046.97DNA polymerase epsilon catalytic subunit A OS=Homo... [more]
sp|Q9WVF7|DPOE1_MOUSE0.000e+047.03DNA polymerase epsilon catalytic subunit A OS=Mus ... [more]
sp|Q9VCN1|DPOE1_DROME7.789e-1646.52DNA polymerase epsilon catalytic subunit 1 OS=Dros... [more]
sp|Q4PFV5|DPOE_USTMA0.000e+038.08DNA polymerase epsilon catalytic subunit A OS=Usti... [more]
sp|O93845|DPOE_EMENI4.504e-1341.63DNA polymerase epsilon catalytic subunit A OS=Emer... [more]
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BLAST of DNA polymerase epsilon catalytic subunit vs. TrEMBL
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL)
Total hits: 5
Match NameE-valueIdentityDescription
V4A1X90.000e+047.68DNA polymerase epsilon catalytic subunit OS=Lottia... [more]
I3K7A90.000e+047.41DNA polymerase epsilon catalytic subunit OS=Oreoch... [more]
A0A1S3INV50.000e+047.41DNA polymerase epsilon catalytic subunit OS=Lingul... [more]
A0A2R2MT890.000e+047.48DNA polymerase epsilon catalytic subunit OS=Lingul... [more]
I3K7B00.000e+047.33DNA polymerase epsilon catalytic subunit OS=Oreoch... [more]
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BLAST of DNA polymerase epsilon catalytic subunit vs. Ensembl Cavefish
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99)
Total hits: 1
Match NameE-valueIdentityDescription
pole0.000e+051.74polymerase (DNA directed), epsilon [Source:ZFIN;Ac... [more]
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BLAST of DNA polymerase epsilon catalytic subunit vs. Ensembl Sea Lamprey
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99)
Total hits: 1
Match NameE-valueIdentityDescription
ENSPMAT00000002970.10.000e+043.68pep scaffold:Pmarinus_7.0:GL476977:35626:117313:1 ... [more]
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BLAST of DNA polymerase epsilon catalytic subunit vs. Ensembl Yeast
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46)
Total hits: 1
Match NameE-valueIdentityDescription
POL20.000e+036.40Catalytic subunit of DNA polymerase (II) epsilon; ... [more]
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BLAST of DNA polymerase epsilon catalytic subunit vs. Ensembl Nematostella
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46)
Total hits: 1
Match NameE-valueIdentityDescription
EDO363420.000e+046.02DNA polymerase [Source:UniProtKB/TrEMBL;Acc:A7SIT... [more]
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BLAST of DNA polymerase epsilon catalytic subunit vs. Ensembl Medaka
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99)
Total hits: 2
Match NameE-valueIdentityDescription
POLE0.000e+061.41DNA polymerase epsilon, catalytic subunit [Source:... [more]
ENSORLT00000046570.12.988e-3424.06pep primary_assembly:ASM223467v1:9:13294875:132973... [more]
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BLAST of DNA polymerase epsilon catalytic subunit vs. Planmine SMEST
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST)
Total hits: 5
Match NameE-valueIdentityDescription
SMESG000044635.10.000e+099.36SMESG000044635.1[more]
SMESG000044635.10.000e+099.36SMESG000044635.1[more]
SMESG000030246.10.000e+092.00SMESG000030246.1[more]
SMESG000044742.18.000e-16685.43SMESG000044742.1[more]
SMESG000044744.17.664e-15590.49SMESG000044744.1[more]
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Sequences
The following sequences are available for this feature:

transcript sequence

>SMED30010451 ID=SMED30010451|Name=DNA polymerase epsilon catalytic subunit|organism=Schmidtea mediterranea sexual|type=transcript|length=7073bp
CCGATCTATTTTAAATTTCTTTTATGAATACTAAGAATAATCAATTTAAA
AATCCCACTGAGAAGGAAAATGACGTATTTGAAGCAATTGAAAGAAATGA
AGAAAAAATATTACGTTTAAAAAAGAATGATCAAATTGATTTAGTATACG
GTTTTGATCTGCATTCGGCGATAAAAATTCGAACGGGATGGCTGATAAAT
ATGAAGACCACAGACGCTATTGATGACAATAAAAGACTAGTTAGTGCCAT
GTCATATTACTTCTTAGAAGAAGATGGCTCGAAATTTAAGTCCACATTAA
TATTCCAGCCATATTTTTATATAGTTACAAAATTAGGCTGTGAAAGCGAA
ATCCAAACATATTTAATGAAAAAATATTCAGCATGTTTGCATAATATAGA
AATTATCGAAAAAGAAGATCTTGATCTCGACAATCATTTAATTGGATTGA
AGAAAATTTTTTTAAAATTAATTTTTCATACTATTGATGACTTGGTTCGG
GTTCGAAAGGAAATAATGCCTAAAATTAAGCAAAATCAAAAGAATCAGGA
ATCCGACAATGATTACTCGAAAATGCTCACTGAACACTTTCAAGGTGAAA
AGAAATATGAATATAATGCGAGAAAATCGGCATTGGACATCATGGACAAC
GCAATAGATATTCGTGAATATGACGTGCCATATCATGTGAGAGTGTCAAT
TGATACGGCAATATTTATCGGCAAATGGTACGATGTACATGGCTCTATGA
ATATCAAAGGACCTAATTCGACTCATATAACTCCAAGATCCGATATAGTT
GACCATCCTGAACCGATCGTCCTTGCATACGACATCGAAACTACAAAGTT
ACCATTGAAATTTCCCGACGCAACATTCGATCAAATCATGATGATTTCCT
ATATGATCGACGGAATGGGATATTTGATTTGCAATCGAGAAATAATCGCT
GACGATATTGAGGATTTTGAATTTACGCCCCGGCCAGAATTCCCCGGGCC
GTTTTCGGTGTTTAATGAGCCGAATGAAAAAAGGACAATCGAACGGTTTT
TCGATCACATTCGAGAAGTAAAACCTAATATTTTCGTCACTTACAACGGG
GATTTTTTCGATTGGCCGTTTGTAGAAACCCGGGCCGTGAAACACGGGTT
GGACATGTTAGATTATATTGGGTTTAGTAAGGACAATCAGAATGAGTACA
AGAGTCGTTCGGCTATCCATATGGACTGTTTCAAATGGGTCCAAAGAGAT
AGCTACCTACCTATCGGCGCTCAAGGATTGAAGGCGGTTTGCAAGGCCAA
ATTACGATATAATCCAGTCGAAGTTGATCCGGAAGAAATGTGTAAAGTCG
CGAGAGAAGATCCCAGAACGTTGGCAAATTACTCAGTCTCAGATGCTGTC
GCAACGTATTATTTATACATGAAATACGTTCATCCTTTTATATTTGCATT
GTGCACGATTATTCCCATGGATCCCGATGAAGTGCTGCGCAAAGGCAGTG
GAACTCTCTGTGAATGTCTATTGATGGTGGAAGCATTCAACTCGAACATT
ATATTTCCCAATAAGCAGGAATCCAAATTGAATCCCCTCACCAATGATGG
GCATGTAATAGAATCTGAAACCTATGTCGGAGGTCACGTCGAAGCCATTG
AATCCGGAGTGTTTAGATCGGACATTCCAACGAAATTCAAAATCGTCCCT
GAAATGTGTAAATTTTTGCGGAAGAACCTAAAAGAAACGCTCGTTCATGT
GCTGGAAGTCGAAGAGAAAGTCACAGTTGATTCGGTTTTAAATTTCGATG
AAGTTTACAATGCAATAGATGAGAAATTAGAAGATTTAGAAGAGACAAAC
ATTCGATTCGAGTGTCCGGTGATATATCATTTGGATGTGGCAGCTATGTA
TCCGAATATCATCCTTTCGAATCGTTTGCAACCGTCCGCTCTTGTCAATG
AGAAAACCTGCGGTGCTTGTGATTTCAACGTACCAAATGCTAAATGCAAA
CGGCCAATGACATGGAAATGGCGAGGCGAAATTATGCCTGCCACAAAATC
AGAATATTATCTCATTCAAAACCAACTGGAAAAAGAGAAATTTCCTCCAA
AGAAACCCAGCTTGCCGATGCGCTCATTTTATGAATTAGACAAACTCGAA
CAAGCCACAGTGGAAAAGGAGCGACTGGGGAAATTCTGTCGAAACGCATA
TAATCGAAAACATAACACTCGGTTTGAAGAAAGAACGGCTGTTGTCTGCC
AAAGAGAAAACGCATTTTATGTCGACACCGTTCGAGCTTTTCGGGATCGT
CGGTATCAATATAAAGATCTGACAAAAGTATCGAAAAAACGATTGGATGA
ATTGATTTCAAGTGAAAATGGTGACGCATCGGAAATCAAGCGTGCAAACG
GAATGTTGGTGTTGTATGATTCGCTTCAATTGGCCCACAAATGCATTCTG
AACTCGTTTTATGGATACGTAATGCGCAAAGGTGCTCGCTGGTACAGTAT
GGAAATGGCGGGAATCGTTTGTTCTACTGGAGCTGCCATCATAAAATATG
CAAGAGAGATGATTGAACAAATCGGCCGACCTCTTGAGCTTGATACCGAT
GGAATCTGGTGTATTCTCCCGGCTAGTTTTCCTCAGGGCTTTGAATTCCA
AACGAATAATCCGAAAAAAAGAAACATCTCGTTCTCTTATCCAGGCGCTA
TGTTGAATCTGATGGTGCAACAATATTTCACCAATGATCAATATCATGAT
CTAGTTGATCCTGCAAAACACACCTATCGAATCCGATCGGAAAATTCGAT
ATTTTTCGAAGTGGACGGCCCGTATCTGGCGATGATTTTACCGGCATCTA
AAGAAATGAATAAGAAATTGAAAAAACGTTACGCAGTATTCAATAGGGAT
CGTTCTCTTGCTGAATTAAAAGGATTTGAAGTAAAACGTAACGGAGAACT
AAATCTTATCAAAATATTTCAATCTTCTGTTTTTGAATCTTTCCTTAAAG
GATCATCGATCAGTGAGGTTTACCAGCATGTTGCAATCGTTGCCAATTAT
TGGCTGGATCTTTTGTATTCCAGGGCTTCCACTATGCCCGATGAAGAGCT
TTTTGAACTGATTTCCGAGAAAAGATGCATGTCGAAGAAATTAGAGGAAT
ATGGAAAACAGAAGTCAACATCGATTAGCACAGCAAGGCGTTTGGCAGAA
TTCCTCGGTGACGAGATGGTGAAAGATGCAGGATTATCATTTAAATTTAT
AATTTCAAAAAAGCCCGAAGGGCAACAAGTAACTGACCGAGCAATTCCAG
TTGCGATTTTTCAGGCTGAAGAATCAGTGAAACGATTCTATTTAAGTAAA
TGGCTGAAATCGAAGGATTTACAAGATTTCGACATCAGAAATATCCTCGA
CTGGGACTATTACATCAACAGATTTAGCAGTAATATACAGAAAATCATTA
CAATTCCAGCTGCTTTGCAAGAGGTTCCTAATCCCGTTCCACGTGTCGCT
CATCCGGATTGGTTGCATAAAATCCTTATGGAAAAGGATAACAGATTCAA
GCAGCAAAGGATTACAGATATTTTCCAGACAATTACACCCAGTCAAGCAG
CCGCTGATAAAATGAAGGACATTGAGAACTGTGCTCCGATATCCAAGAAA
AAACCAACTGGAGTCACCTCATTGAAGCGAGCCAGAAATAAGGATACAGT
TGACGTATACGGGGTACAGCTGGACATGGATAATTTACCAAATCATTGGC
GTGATATACTTGGGGATCCAGTCCCTAAAGGTAATAGTAAGTCCCAATTC
ATTGTGTGGCTGGAGTTCCACAAAAAGAAATGGAAAATTCAAAAGATAAT
CAAAGACCAATCAGAATTGAGTAAAGAAAATATCAATCCTGCCACGGTAA
AACGAATAAAAACTGTTAAAAAAGGAATTCAGAGTGGAATATCTTCGTTT
TTTACTCGATCCAAACAATCGATCCTGGAGGATACTTGGCAGATTATCCA
AATCACCGACACAAATGTTTCTGGAATCTATCGTGTTTGGGTATTAATTG
GCCAGGAAATTCACAACATGAAGTTGACAGTTCCTCGTACATTCTATGTA
AACACGAGAATCCCCAAAGCACCCGGAGAAAATATGTATTTTAAACAAGT
TCACAAGTTATTGCCGAGATCTCGTATTGTCTATCACCTTTACGAGTACA
ATCTTGACGAGACGATTTTTATCAAGCATCGATCAGACATTTTATCGGAA
TTCATTAGGAACGAAGTGGAAGGAATATATGAATTAGAAGTGCCGTTATT
GTTGCGAGTTTACGCAAAATTGGGGTGCATGTGTTCCATCGATCGGAATC
ACTTCACTGATCAACAGCTGTCAAATAATCCCTCGAGTTTCCTATTAAAT
GAACTGAAATTCCGATCAACTGCCCAGCATCCATATCTTTCACCAAATTC
AATCAAAACCACCTTTCTATTCCAACAGAAATCCAACAGAAACGAAATTA
TCGGCTGGTTTGATCCGTGTAACAACCGAGCTCATCTTTGTCTAGTTGAA
CAATCTAAACCGAATCCCGATAAATTCCAAGCGAATGTTGTCCAATCTTG
GTTCTCAAGAGAAAGGGAAGCTTTTTTATCATTAAAAGAAAATGAATCCT
TGATATCAGTCGTACCAGAACATGTGCAATTCGAGGTTTCCAGTCACAAA
TTTGAAATAAGCGCCTTCAAGGCAATCAACAAGCTGTTAGTGGCACACCG
AAATGAAGTGACTACCCCAACATTTATTGCAACAAAATCCAAAATGACAA
TTAATGAATTATATTCAAACTTGCCTGCCTTACAAGAATATCCCTTGGTG
CCGATCACAATCAATGAAACTGACGTCTCCTTTAATGTGCTCGATTGGCA
ACGAATCGCCATCAAATCCGCCCTCCAGAACTTTGTTAAGTATGAAAAGT
TATTGGCGGAAATGCTGGAACGTGCAAGATATCTCCATATTCCGGTGGGG
AACATGAGCAAATTCACCAATGATTATCGAGGAATTTCCGATAGCTATGA
TTTGTTTTATGGAAGATTTCTGATGAAAAACAATTTCATTTGGTGGTGCA
ATGATAAATCGGAACCGGATTTGGGTAAGAAAGAAAACCAAGATCGTCGT
ATGATGCTTGTCGATAATGATGTGCTGAATGGAATGATTTACCGCAACAA
ACCCGGTTGTTATCCGACTACTTGTGTCCAATTAGAAATGACTTATTTTC
CCATCAATACGATCATTGCTATGCATAAAGTTATGGAAATAGATGGCACC
AATGAAAGACTGTTTGAGTCAATGATAGTTCCAGCAAAAACAATTGATCA
AGCAATGATACAGTCCAAATGTAATGCCGCCAAACGCAACCTGAATCTAA
CCAGCAACACCATGTATGATGACGTCACTGCAGCCGGACCGGCTTTTAAA
ATCCTGAGGAATGTCATCCTTCAATGGCTGGATGATGTGAGAAACTACAA
AAATCCGGTTGCCGATGAACATTTAATGGGATTCTATAAATGGATGAAAA
ATTCCCGATCTTTGTTTTATGATCCGGCATTATTCAAATCTCTTCAGAAA
TTAATGAGAATGGTCTTTTTCAAACTGATAGAGCAACTGAATAATCTCGG
AGTAGAAGTGATTTATGGGACTCTGAATAAAATTGTGCTCTGTACAAAAC
GGACTGATTTAATGGACGCGCTGGTACATGTTGAATATGCAACGAAAACC
GTGAGAAATCAAGACATTTTCAGTCAGCTCGACTTTCAATATGTTTCCGG
TTGGGACTATTTGATATGGCAGGACGTCAGTAATTATAGCGGAATCAAAT
CCGATCTGGAATCGGTAACGAAAGAAGAGCACAATTCGATGGTGTTAGAA
GAACTTTCATTTGTGAATATGACGAATCCATCATTGTCGATGGGCTTATC
CCAGAGCCAGAATGAGGACAGCTTTTTGACTACGGAAATCGCTGACAGCA
GTCAAATTGAAATGAATTGGCATTTGTCGCGATATTTATCACCAATGAGT
GGCGTCCAATTGAGATTGATTGAGATATTGCAATATTTCATGCTGACCAA
TTGGAAAATAGTAAAGGATGAATACAAATTGAACCGATTGGCTGCTAAGA
ATGACGTTGCAGAGGAAGCAGTGAATACCGGGACGATATTGGGTTCCGAT
GCCAGCCTTTATCCAAGCAGTGTTCAGCGAATGGAAGATTTCCTGCAGAA
TGAAATGGGATACAAATTGTATTTATTGGTGTCGCAATTGAAGGATGTTC
CCCGGATGCACAATGCAGTCCCGTTGACAACTGATGATGATGATGACAAG
GAGGGTGAAGATGAAAGCAACAAAACTCCACCTTTGTTGCCGTTGAAAAA
TAAAGTTTCCCTTCATCCAATCGTCGATTTGATTAAAACAACGTGTCACA
TTCTGGCTCTCGATACGTCCGCTCGTTATTACGTCAATGATTGGAAACGG
AACATGTTCAAATTGATCAATTTTGATGCCTATTCCGATCAAGCAAAATG
GCGATCACCATATTCGTCGGATCAATCAATGGGAGACGCTTTCAGATCAG
ATTTGATTATTACAGTGCCGGAAGTGATTTGTGACAATTGCAATGTTACA
CGAGACCTGGATTTGTGTAGGGATCTTTATCAAGTACGCATTAAGAACAG
CTGGTGGTTTGTGTGTCCCACATGTGACTTTCCGTATGACAGAAATGTGA
TCCAGGAAACTCTGATCGACCAAGTAAGATGTATCTGTGAATCGAATGTG
ATGCAGGACTTGAAATGCACTAAATGTACAAACGGAATATTGGAAACATC
TTTAGCCGGGACAGAAAATTGTGTAAAATGTGGTAATGCGATTCAAGTCA
CCCAAAATGCGGCATCCTTGAAAGAAAAGATCAAAATTTATGCAGATATC
GGTAAACATTACGATTTGCCATATCTTCACATGATGACTTCCTGGATGTT
GCAGGGGGAGGACTTATCATAGATGTTATTTAATTTGATTTTAAATAGAT
TTTTAGTGTCTTTTCAAAAAAAA
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protein sequence of SMED30010451-orf-1

>SMED30010451-orf-1 ID=SMED30010451-orf-1|Name=SMED30010451-orf-1|organism=Schmidtea mediterranea sexual|type=polypeptide|length=2333bp
MNTKNNQFKNPTEKENDVFEAIERNEEKILRLKKNDQIDLVYGFDLHSAI
KIRTGWLINMKTTDAIDDNKRLVSAMSYYFLEEDGSKFKSTLIFQPYFYI
VTKLGCESEIQTYLMKKYSACLHNIEIIEKEDLDLDNHLIGLKKIFLKLI
FHTIDDLVRVRKEIMPKIKQNQKNQESDNDYSKMLTEHFQGEKKYEYNAR
KSALDIMDNAIDIREYDVPYHVRVSIDTAIFIGKWYDVHGSMNIKGPNST
HITPRSDIVDHPEPIVLAYDIETTKLPLKFPDATFDQIMMISYMIDGMGY
LICNREIIADDIEDFEFTPRPEFPGPFSVFNEPNEKRTIERFFDHIREVK
PNIFVTYNGDFFDWPFVETRAVKHGLDMLDYIGFSKDNQNEYKSRSAIHM
DCFKWVQRDSYLPIGAQGLKAVCKAKLRYNPVEVDPEEMCKVAREDPRTL
ANYSVSDAVATYYLYMKYVHPFIFALCTIIPMDPDEVLRKGSGTLCECLL
MVEAFNSNIIFPNKQESKLNPLTNDGHVIESETYVGGHVEAIESGVFRSD
IPTKFKIVPEMCKFLRKNLKETLVHVLEVEEKVTVDSVLNFDEVYNAIDE
KLEDLEETNIRFECPVIYHLDVAAMYPNIILSNRLQPSALVNEKTCGACD
FNVPNAKCKRPMTWKWRGEIMPATKSEYYLIQNQLEKEKFPPKKPSLPMR
SFYELDKLEQATVEKERLGKFCRNAYNRKHNTRFEERTAVVCQRENAFYV
DTVRAFRDRRYQYKDLTKVSKKRLDELISSENGDASEIKRANGMLVLYDS
LQLAHKCILNSFYGYVMRKGARWYSMEMAGIVCSTGAAIIKYAREMIEQI
GRPLELDTDGIWCILPASFPQGFEFQTNNPKKRNISFSYPGAMLNLMVQQ
YFTNDQYHDLVDPAKHTYRIRSENSIFFEVDGPYLAMILPASKEMNKKLK
KRYAVFNRDRSLAELKGFEVKRNGELNLIKIFQSSVFESFLKGSSISEVY
QHVAIVANYWLDLLYSRASTMPDEELFELISEKRCMSKKLEEYGKQKSTS
ISTARRLAEFLGDEMVKDAGLSFKFIISKKPEGQQVTDRAIPVAIFQAEE
SVKRFYLSKWLKSKDLQDFDIRNILDWDYYINRFSSNIQKIITIPAALQE
VPNPVPRVAHPDWLHKILMEKDNRFKQQRITDIFQTITPSQAAADKMKDI
ENCAPISKKKPTGVTSLKRARNKDTVDVYGVQLDMDNLPNHWRDILGDPV
PKGNSKSQFIVWLEFHKKKWKIQKIIKDQSELSKENINPATVKRIKTVKK
GIQSGISSFFTRSKQSILEDTWQIIQITDTNVSGIYRVWVLIGQEIHNMK
LTVPRTFYVNTRIPKAPGENMYFKQVHKLLPRSRIVYHLYEYNLDETIFI
KHRSDILSEFIRNEVEGIYELEVPLLLRVYAKLGCMCSIDRNHFTDQQLS
NNPSSFLLNELKFRSTAQHPYLSPNSIKTTFLFQQKSNRNEIIGWFDPCN
NRAHLCLVEQSKPNPDKFQANVVQSWFSREREAFLSLKENESLISVVPEH
VQFEVSSHKFEISAFKAINKLLVAHRNEVTTPTFIATKSKMTINELYSNL
PALQEYPLVPITINETDVSFNVLDWQRIAIKSALQNFVKYEKLLAEMLER
ARYLHIPVGNMSKFTNDYRGISDSYDLFYGRFLMKNNFIWWCNDKSEPDL
GKKENQDRRMMLVDNDVLNGMIYRNKPGCYPTTCVQLEMTYFPINTIIAM
HKVMEIDGTNERLFESMIVPAKTIDQAMIQSKCNAAKRNLNLTSNTMYDD
VTAAGPAFKILRNVILQWLDDVRNYKNPVADEHLMGFYKWMKNSRSLFYD
PALFKSLQKLMRMVFFKLIEQLNNLGVEVIYGTLNKIVLCTKRTDLMDAL
VHVEYATKTVRNQDIFSQLDFQYVSGWDYLIWQDVSNYSGIKSDLESVTK
EEHNSMVLEELSFVNMTNPSLSMGLSQSQNEDSFLTTEIADSSQIEMNWH
LSRYLSPMSGVQLRLIEILQYFMLTNWKIVKDEYKLNRLAAKNDVAEEAV
NTGTILGSDASLYPSSVQRMEDFLQNEMGYKLYLLVSQLKDVPRMHNAVP
LTTDDDDDKEGEDESNKTPPLLPLKNKVSLHPIVDLIKTTCHILALDTSA
RYYVNDWKRNMFKLINFDAYSDQAKWRSPYSSDQSMGDAFRSDLIITVPE
VICDNCNVTRDLDLCRDLYQVRIKNSWWFVCPTCDFPYDRNVIQETLIDQ
VRCICESNVMQDLKCTKCTNGILETSLAGTENCVKCGNAIQVTQNAASLK
EKIKIYADIGKHYDLPYLHMMTSWMLQGEDLS*
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Annotated Terms
The following terms have been associated with this transcript:
Vocabulary: Planarian Anatomy
TermDefinition
PLANA:0000014zeta neoblast
PLANA:0000070intestinal phagocyte
PLANA:0000429neoblast
PLANA:0002109X1 cell
Vocabulary: INTERPRO
TermDefinition
IPR042087DNA_pol_B_C
IPR036397RNaseH_sf
IPR029703POL2
IPR013697DNA_pol_e_suA_C
IPR006172DNA-dir_DNA_pol_B
IPR006134DNA-dir_DNA_pol_B_multi_dom
IPR006133DNA-dir_DNA_pol_B_exonuc
IPR012337RNaseH-like_sf
Vocabulary: molecular function
TermDefinition
GO:0008270zinc ion binding
GO:0003887DNA-directed DNA polymerase activity
GO:0003676nucleic acid binding
GO:0000166nucleotide binding
GO:0003677DNA binding
GO:00084083'-5' exonuclease activity
GO:0003682chromatin binding
GO:0008310single-stranded DNA 3'-5' exodeoxyribonuclease activity
GO:0016740transferase activity
GO:0016779nucleotidyltransferase activity
GO:0046872metal ion binding
GO:0051536iron-sulfur cluster binding
GO:00515394 iron, 4 sulfur cluster binding
Vocabulary: cellular component
TermDefinition
GO:0005634nucleus
GO:0005654nucleoplasm
GO:0005886plasma membrane
GO:0008622epsilon DNA polymerase complex
Vocabulary: biological process
TermDefinition
GO:0006260DNA replication
GO:0000082G1/S transition of mitotic cell cycle
GO:0000278mitotic cell cycle
GO:0000731DNA synthesis involved in DNA repair
GO:0006272leading strand elongation
GO:0006281DNA repair
GO:0006287base-excision repair, gap-filling
GO:0006297nucleotide-excision repair, DNA gap filling
GO:0006974cellular response to DNA damage stimulus
GO:0045004DNA replication proofreading
GO:0048568embryonic organ development
GO:0071897DNA biosynthetic process
GO:0090305nucleic acid phosphodiester bond hydrolysis
InterPro
Analysis Name: Schmidtea mediteranean smed_20140614 Interproscan
Date Performed: 2020-05-01
IPR TermIPR DescriptionSourceSource TermSource DescriptionAlignment
NoneNo IPR availableCOILSCoilCoilcoord: 1630..1650
NoneNo IPR availableCOILSCoilCoilcoord: 2330..2331
NoneNo IPR availablePANTHERPTHR10670:SF0DNA POLYMERASE EPSILON CATALYTIC SUBUNIT Acoord: 31..2324
NoneNo IPR availableCDDcd05535POLBc_epsiloncoord: 526..1149
e-value: 0.0
score: 1112.36
NoneNo IPR availableCDDcd05779DNA_polB_epsilon_exocoord: 263..466
e-value: 1.35042E-137
score: 425.521
NoneNo IPR availableSUPERFAMILYSSF56672DNA/RNA polymerasescoord: 491..1142
IPR013697DNA polymerase epsilon, catalytic subunit A, C-terminalSMARTSM01159DUF1744_2coord: 1522..1941
e-value: 4.1E-87
score: 305.4
IPR013697DNA polymerase epsilon, catalytic subunit A, C-terminalPFAMPF08490DUF1744coord: 1525..1941
e-value: 5.8E-94
score: 314.9
IPR006172DNA-directed DNA polymerase, family BSMARTSM00486polmehr3coord: 262..867
e-value: 7.5E-77
score: 271.3
IPR042087DNA polymerase family B, C-terminal domainGENE3DG3DSA:1.10.132.60coord: 949..1069
e-value: 2.7E-7
score: 32.4
IPR006133DNA-directed DNA polymerase, family B, exonuclease domainPFAMPF03104DNA_pol_B_exo1coord: 81..422
e-value: 1.3E-71
score: 241.5
IPR006134DNA-directed DNA polymerase, family B, multifunctional domainPFAMPF00136DNA_pol_Bcoord: 617..1142
e-value: 3.1E-11
score: 42.7
IPR036397Ribonuclease H superfamilyGENE3DG3DSA:3.30.420.10coord: 266..464
e-value: 1.7E-58
score: 199.5
IPR029703DNA polymerase epsilon catalytic subunitPANTHERPTHR10670DNA POLYMERASE EPSILON CATALYTIC SUBUNIT Acoord: 31..2324
IPR012337Ribonuclease H-like superfamilySUPERFAMILYSSF53098Ribonuclease H-likecoord: 63..512