COP9 signalosome complex subunit 1

Overview


Name	COP9 signalosome complex subunit 1
Smed ID	SMED30010138
Length (bp)	1672

Neoblast Clusters

▻ Sub-lethal Irradiated Surviving X1 and X2 Cell Population

Overview

Single cell RNA-seq of pluripotent neoblasts and its early progenies

We isolated X1 neoblasts cells enriched in high piwi-1 expression (Neoblast Population), and profiled ∼7,614 individual cells via scRNA-seq. Unsupervised analyses uncovered 12 distinct classes from 7,088 high-quality cells. We designated these classes Nb1 to Nb12 and ordered them based on high (Nb1) to low (Nb12) piwi-1 expression levels. We further defined groups of genes that best classified the cells parsed into 12 distinct cell clusters to generate a scaled expression heat map of discriminative gene sets for each cluster. Expression of each cluster’s gene signatures was validated using multiplex fluorescence in situ hybridization (FISH) co-stained with piwi-1 and largely confirmed the cell clusters revealed by scRNA-seq.

We also tested sub-lethal irradiation exposure. To profile rare pluripotent stem cells (PSCs) and avoid interference from immediate progenitor cells, we determined a time point after sub-lethal irradiation (7 DPI) with minimal piwi-1+ cells, followed by isolation and single-cell RNA-seq of 1,200 individual cells derived from X1 (Piwi-1 high) and X2 (Piwi-1 low) cell populations (Sub-lethal Irradiated Surviving X1 and X2 Cell Population)

Explore this single cell expression dataset with our NB Cluster Shiny App

Neoblast Population

t-SNE plot shows two-dimensional representation of global gene expression relationships among all neoblasts (n = 7,088 after filter). Cluster identity was assigned based on the top 10 marker genes of each cluster (Table S2), followed by inspection of RNA in situ hybridization patterns. Neoblast groups, Nb.

Expression of COP9 signalosome complex subunit 1 (SMED30010138) t-SNE clustered cells

Violin plots show distribution of expression levels for COP9 signalosome complex subunit 1 (SMED30010138) in cells (dots) of each of the 12 neoblast clusters.

Sub-lethal Irradiated Surviving X1 and X2 Cell Population

t-SNE plot of surviving X1 and X2 cells (n = 1,039 after QC filter) after sub-lethal irradiation. Colors indicate unbiased cell classification via graph-based clustering. SL, sub-lethal irradiated cell groups.

Expression of COP9 signalosome complex subunit 1 (SMED30010138) in the t-SNE clustered sub-lethally irradiated X1 and X2 cells.

Violin plots show distribution of expression levels for COP9 signalosome complex subunit 1 (SMED30010138) in cells (dots) of each of the 10 clusters of sub-leathally irradiated X1 and X2 cells.

Embryonic Expression

Davies et. al., 2017

Hover the mouse over a column in the graph to view average RPKM values per sample.
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Embryonic Stages: Y: yolk. S2-S8: Stages 2-8. C4: asexual adult. SX: virgin, sexually mature adult.
For further information about sample preparation and analysis for the single animal RNA-Seq experiment, please refer to the Materials and Methods

Anatomical Expression

PAGE et. al., 2020

SMED30010138

has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGE

PAGE Curations: 2

Expressed In	Reference Transcript	Gene Models	Published Transcript	Transcriptome	Publication	Specimen	Lifecycle	Evidence
posterior side	SMED30010138	SMESG000027211.1	dd_Smed_v4_2705_0_1	dd_Smed_v4	PMID:29674431 Fincher et al., 2018
posterior muscle cell	SMED30010138	SMESG000027211.1	dd_Smed_v4_2705_0_1	dd_Smed_v4	PMID:29674431 Fincher et al., 2018

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Homology

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BLAST of COP9 signalosome complex subunit 1 vs. Ensembl Human
Match: GPS1 (G protein pathway suppressor 1 [Source:HGNC Symbol;Acc:HGNC:4549])

HSP 1 Score: 320.857 bits (821), Expect = 4.188e-103
Identity = 182/515 (35.34%), Postives = 289/515 (56.12%), Query Frame = 1

Query:   28 IFCKMSMIEHMQLDLIEEDETISLLNDSPLQEVTE-TTLDLDTYINNYKDFGKYLRLIFIARRCRPLRLEALVIALDWLKQSWNFVEYCKVFNIIATVVRDSIEMADATLTTLIPGVCCRDDFNFQRFQTRVSYETIRLPDGRFLEFDSDWVDKTRRQSNQTIDQLDTDLKNYKANNMAESIRRGCDELASVHMKTGDLLSANKNYTRSRDYCKTDMHELMMCFNVIKVSIYLTHWRHVSSYVDRAETLLENITNGCSSTGSQNRSISDEVSGSWKQSSNTEKVTSDQKDNRQKMKALLHCVVGLVEMYERNFXXXXXXFLQADHDYVSFNSILTANDVALYGTICSLATFDRNALKSMVIQNSNFKMFLENEPTLRDILHNFYNFQYAECLKGMAQIKNQLLLDIYLADHVEYLYREIRNRALCQYFSPYQCADLNKIATCFNTSVPELLQELKPLISTGQLKAKIDSHNNLLLVTSISQQNQVFQRAFHLFNSYEKRFKATFVHNACIRSELY 1569
            +F     +E MQ+D+  +++     N   +  V E  +LDL+ Y  +Y    +  RL FIA  C  LR+EAL +AL ++++++N   Y ++   ++   R S+                      Q     +    +  P       D+ WV+ TR+++   +++LDTDLKNYK N++ ESIRRG D+L   ++  GDL +A K Y+R+RDYC +  H + MC NVIKVS+YL +W HV SYV +AE+                   + E++   ++ S T+ + +            L C  GL E+  R +  AA+  L A  D+  F  +L+ ++VA+YG +C+LATFDR  L+  VI +S+FK+FLE EP +RDI+  FY  +YA CLK + ++K+ LLLD+YLA HV  LY +IRNRAL QYFSPY  AD++++A  FNT+V  L  EL  LI  G + A++DSH+ +L    + Q++  F+++  +   +++R KA  +  A +R++++
Sbjct:    7 VFNLQGAVEPMQIDVDPQEDP---QNAPDVNYVVENPSLDLEQYAASYSGLMRIERLQFIADHCPTLRVEALKMALSFVQRTFNVDMYEEIHRKLSEATRSSLR-------------------ELQNAPDAIPESGVEPP-----ALDTAWVEATRKKALLKLEKLDTDLKNYKGNSIKESIRRGHDDLGDHYLDCGDLSNALKCYSRARDYCTSAKHVINMCLNVIKVSVYLQNWSHVLSYVSKAES-------------------TPEIAERGERDSQTQAILTK-----------LKCAAGLAELAARKYKQAAKCLLLASFDHCDFPELLSPSNVAIYGGLCALATFDRQELQRNVISSSSFKLFLELEPQVRDIIFKFYESKYASCLKMLDEMKDNLLLDMYLAPHVRTLYTQIRNRALIQYFSPYVSADMHRMAAAFNTTVAALEDELTQLILEGLISARVDSHSKILYARDVDQRSTTFEKSLLMGKEFQRRAKAMMLRAAVLRNQIH 464

[Close]

BLAST of COP9 signalosome complex subunit 1 vs. Ensembl Human
Match: GPS1 (G protein pathway suppressor 1 [Source:HGNC Symbol;Acc:HGNC:4549])

HSP 1 Score: 319.316 bits (817), Expect = 1.726e-102
Identity = 185/515 (35.92%), Postives = 291/515 (56.50%), Query Frame = 1

Query:   28 IFCKMSMIEHMQLDLIEEDETISLLNDSPLQEVTE-TTLDLDTYINNYKDFGKYLRLIFIARRCRPLRLEALVIALDWLKQSWNFVEYCKVFNIIATVVRDSIEMADATLTTLIPGVCCRDDFNFQRFQTRVSYETIRLPDGRFLEFDSDWVDKTRRQSNQTIDQLDTDLKNYKANNMAESIRRGCDELASVHMKTGDLLSANKNYTRSRDYCKTDMHELMMCFNVIKVSIYLTHWRHVSSYVDRAETLLENITNGCSSTGSQNRSISDEVSGSWKQSSNTEKVTSDQKDNRQKMKALLHCVVGLVEMYERNFXXXXXXFLQADHDYVSFNSILTANDVALYGTICSLATFDRNALKSMVIQNSNFKMFLENEPTLRDILHNFYNFQYAECLKGMAQIKNQLLLDIYLADHVEYLYREIRNRALCQYFSPYQCADLNKIATCFNTSVPELLQELKPLISTGQLKAKIDSHNNLLLVTSISQQNQVFQRAFHLFNSYEKRFKATFVHNACIRSELY 1569
            +F     +E MQ+D+  +++     N   +  V E  +LDL+ Y  +Y    +  RL FIA  C  LR+EAL +AL ++++++N   Y ++   ++   R+     DA     IP                   E+   P       D+ WV+ TR+++   +++LDTDLKNYK N++ ESIRRG D+L   ++  GDL +A K Y+R+RDYC +  H + MC NVIKVS+YL +W HV SYV +AE+                   + E++   ++ S T+ + +            L C  GL E+  R +  AA+  L A  D+  F  +L+ ++VA+YG +C+LATFDR  L+  VI +S+FK+FLE EP +RDI+  FY  +YA CLK + ++K+ LLLD+YLA HV  LY +IRNRAL QYFSPY  AD++++A  FNT+V  L  EL  LI  G + A++DSH+ +L    + Q++  F+++  +   +++R KA  +  A +R++++
Sbjct:    7 VFNLQGAVEPMQIDVDPQEDP---QNAPDVNYVVENPSLDLEQYAASYSGLMRIERLQFIADHCPTLRVEALKMALSFVQRTFNVDMYEEIHRKLSEATRELQNAPDA-----IP-------------------ESGVEPPA----LDTAWVEATRKKALLKLEKLDTDLKNYKGNSIKESIRRGHDDLGDHYLDCGDLSNALKCYSRARDYCTSAKHVINMCLNVIKVSVYLQNWSHVLSYVSKAES-------------------TPEIAERGERDSQTQAILTK-----------LKCAAGLAELAARKYKQAAKCLLLASFDHCDFPELLSPSNVAIYGGLCALATFDRQELQRNVISSSSFKLFLELEPQVRDIIFKFYESKYASCLKMLDEMKDNLLLDMYLAPHVRTLYTQIRNRALIQYFSPYVSADMHRMAAAFNTTVAALEDELTQLILEGLISARVDSHSKILYARDVDQRSTTFEKSLLMGKEFQRRAKAMMLRAAVLRNQIH 460

[Close]

BLAST of COP9 signalosome complex subunit 1 vs. Ensembl Human
Match: GPS1 (G protein pathway suppressor 1 [Source:HGNC Symbol;Acc:HGNC:4549])

HSP 1 Score: 317.775 bits (813), Expect = 5.908e-102
Identity = 184/515 (35.73%), Postives = 286/515 (55.53%), Query Frame = 1

Query:   28 IFCKMSMIEHMQLDLIEEDETISLLNDSPLQEVTE-TTLDLDTYINNYKDFGKYLRLIFIARRCRPLRLEALVIALDWLKQSWNFVEYCKVFNIIATVVRDSIEMADATLTTLIPGVCCRDDFNFQRFQTRVSYETIRLPDGRFLEFDSDWVDKTRRQSNQTIDQLDTDLKNYKANNMAESIRRGCDELASVHMKTGDLLSANKNYTRSRDYCKTDMHELMMCFNVIKVSIYLTHWRHVSSYVDRAETLLENITNGCSSTGSQNRSISDEVSGSWKQSSNTEKVTSDQKDNRQKMKALLHCVVGLVEMYERNFXXXXXXFLQADHDYVSFNSILTANDVALYGTICSLATFDRNALKSMVIQNSNFKMFLENEPTLRDILHNFYNFQYAECLKGMAQIKNQLLLDIYLADHVEYLYREIRNRALCQYFSPYQCADLNKIATCFNTSVPELLQELKPLISTGQLKAKIDSHNNLLLVTSISQQNQVFQRAFHLFNSYEKRFKATFVHNACIRSELY 1569
            +F     +E MQ+D+  +++     N   +  V E  +LDL+ Y  +Y    +  RL FIA  C  LR+EAL +AL ++++++N   Y ++   ++   R S+                      Q     +    +  P       D+ WV+ TR+++   +++LDTDLKNYK N++ ESIRRG D+L   ++  GDL +A K Y+R+RDYC +  H + MC NVIKVS+YL +W HV SYV +AE+  E I        SQ ++I  +                            L C  GL E+  R +  AA+  L A  D+  F  +L+ ++VA+YG +C+LATFDR  L+  VI +S+FK+FLE EP +RDI+  FY  +YA CLK + ++K+ LLLD+YLA HV  LY +IRNRAL QYFSPY  AD++++A  FNT+V  L  EL  LI  G + A++DSH+ +L    + Q++  F+++  +   +++R KA  +  A +R++++
Sbjct:    7 VFNLQGAVEPMQIDVDPQEDP---QNAPDVNYVVENPSLDLEQYAASYSGLMRIERLQFIADHCPTLRVEALKMALSFVQRTFNVDMYEEIHRKLSEATRSSLR-------------------ELQNAPDAIPESGVEPP-----ALDTAWVEATRKKALLKLEKLDTDLKNYKGNSIKESIRRGHDDLGDHYLDCGDLSNALKCYSRARDYCTSAKHVINMCLNVIKVSVYLQNWSHVLSYVSKAESTPE-IAEQRGERDSQTQAILTK----------------------------LKCAAGLAELAARKYKQAAKCLLLASFDHCDFPELLSPSNVAIYGGLCALATFDRQELQRNVISSSSFKLFLELEPQVRDIIFKFYESKYASCLKMLDEMKDNLLLDMYLAPHVRTLYTQIRNRALIQYFSPYVSADMHRMAAAFNTTVAALEDELTQLILEGLISARVDSHSKILYARDVDQRSTTFEKSLLMGKEFQRRAKAMMLRAAVLRNQIH 465

[Close]

BLAST of COP9 signalosome complex subunit 1 vs. Ensembl Human
Match: GPS1 (G protein pathway suppressor 1 [Source:HGNC Symbol;Acc:HGNC:4549])

HSP 1 Score: 317.775 bits (813), Expect = 2.015e-101
Identity = 184/508 (36.22%), Postives = 289/508 (56.89%), Query Frame = 1

Query:   49 IEHMQLDLIEEDETISLLNDSPLQEVTE-TTLDLDTYINNYKDFGKYLRLIFIARRCRPLRLEALVIALDWLKQSWNFVEYCKVFNIIATVVRDSIEMADATLTTLIPGVCCRDDFNFQRFQTRVSYETIRLPDGRFLEFDSDWVDKTRRQSNQTIDQLDTDLKNYKANNMAESIRRGCDELASVHMKTGDLLSANKNYTRSRDYCKTDMHELMMCFNVIKVSIYLTHWRHVSSYVDRAETLLENITNGCSSTGSQNRSISDEVSGSWKQSSNTEKVTSDQKDNRQKMKALLHCVVGLVEMYERNFXXXXXXFLQADHDYVSFNSILTANDVALYGTICSLATFDRNALKSMVIQNSNFKMFLENEPTLRDILHNFYNFQYAECLKGMAQIKNQLLLDIYLADHVEYLYREIRNRALCQYFSPYQCADLNKIATCFNTSVPELLQELKPLISTGQLKAKIDSHNNLLLVTSISQQNQVFQRAFHLFNSYEKRFKATFVHNACIRSELY 1569
            +E MQ+D+  +++     N   +  V E  +LDL+ Y  +Y    +  RL FIA  C  LR+EAL +AL ++++++N   Y ++   ++   R+     DA     IP                   E+   P       D+ WV+ TR+++   +++LDTDLKNYK N++ ESIRRG D+L   ++  GDL +A K Y+R+RDYC +  H + MC NVIKVS+YL +W HV SYV +AE+                   + E++   ++ S T+ + +            L C  GL E+  R +  AA+  L A  D+  F  +L+ ++VA+YG +C+LATFDR  L+  VI +S+FK+FLE EP +RDI+  FY  +YA CLK + ++K+ LLLD+YLA HV  LY +IRNRAL QYFSPY  AD++++A  FNT+V  L  EL  LI  G + A++DSH+ +L    + Q++  F+++  +   +++R KA  +  A +R++++
Sbjct:   54 VEPMQIDVDPQEDP---QNAPDVNYVVENPSLDLEQYAASYSGLMRIERLQFIADHCPTLRVEALKMALSFVQRTFNVDMYEEIHRKLSEATRELQNAPDA-----IP-------------------ESGVEPPA----LDTAWVEATRKKALLKLEKLDTDLKNYKGNSIKESIRRGHDDLGDHYLDCGDLSNALKCYSRARDYCTSAKHVINMCLNVIKVSVYLQNWSHVLSYVSKAES-------------------TPEIAERGERDSQTQAILTK-----------LKCAAGLAELAARKYKQAAKCLLLASFDHCDFPELLSPSNVAIYGGLCALATFDRQELQRNVISSSSFKLFLELEPQVRDIIFKFYESKYASCLKMLDEMKDNLLLDMYLAPHVRTLYTQIRNRALIQYFSPYVSADMHRMAAAFNTTVAALEDELTQLILEGLISARVDSHSKILYARDVDQRSTTFEKSLLMGKEFQRRAKAMMLRAAVLRNQIH 500

[Close]

BLAST of COP9 signalosome complex subunit 1 vs. Ensembl Human
Match: GPS1 (G protein pathway suppressor 1 [Source:HGNC Symbol;Acc:HGNC:4549])

HSP 1 Score: 316.235 bits (809), Expect = 2.211e-101
Identity = 187/515 (36.31%), Postives = 288/515 (55.92%), Query Frame = 1

Query:   28 IFCKMSMIEHMQLDLIEEDETISLLNDSPLQEVTE-TTLDLDTYINNYKDFGKYLRLIFIARRCRPLRLEALVIALDWLKQSWNFVEYCKVFNIIATVVRDSIEMADATLTTLIPGVCCRDDFNFQRFQTRVSYETIRLPDGRFLEFDSDWVDKTRRQSNQTIDQLDTDLKNYKANNMAESIRRGCDELASVHMKTGDLLSANKNYTRSRDYCKTDMHELMMCFNVIKVSIYLTHWRHVSSYVDRAETLLENITNGCSSTGSQNRSISDEVSGSWKQSSNTEKVTSDQKDNRQKMKALLHCVVGLVEMYERNFXXXXXXFLQADHDYVSFNSILTANDVALYGTICSLATFDRNALKSMVIQNSNFKMFLENEPTLRDILHNFYNFQYAECLKGMAQIKNQLLLDIYLADHVEYLYREIRNRALCQYFSPYQCADLNKIATCFNTSVPELLQELKPLISTGQLKAKIDSHNNLLLVTSISQQNQVFQRAFHLFNSYEKRFKATFVHNACIRSELY 1569
            +F     +E MQ+D+  +++     N   +  V E  +LDL+ Y  +Y    +  RL FIA  C  LR+EAL +AL ++++++N   Y ++   ++   R+     DA     IP                   E+   P       D+ WV+ TR+++   +++LDTDLKNYK N++ ESIRRG D+L   ++  GDL +A K Y+R+RDYC +  H + MC NVIKVS+YL +W HV SYV +AE+  E I        SQ ++I  +                            L C  GL E+  R +  AA+  L A  D+  F  +L+ ++VA+YG +C+LATFDR  L+  VI +S+FK+FLE EP +RDI+  FY  +YA CLK + ++K+ LLLD+YLA HV  LY +IRNRAL QYFSPY  AD++++A  FNT+V  L  EL  LI  G + A++DSH+ +L    + Q++  F+++  +   +++R KA  +  A +R++++
Sbjct:    7 VFNLQGAVEPMQIDVDPQEDP---QNAPDVNYVVENPSLDLEQYAASYSGLMRIERLQFIADHCPTLRVEALKMALSFVQRTFNVDMYEEIHRKLSEATRELQNAPDA-----IP-------------------ESGVEPPA----LDTAWVEATRKKALLKLEKLDTDLKNYKGNSIKESIRRGHDDLGDHYLDCGDLSNALKCYSRARDYCTSAKHVINMCLNVIKVSVYLQNWSHVLSYVSKAESTPE-IAEQRGERDSQTQAILTK----------------------------LKCAAGLAELAARKYKQAAKCLLLASFDHCDFPELLSPSNVAIYGGLCALATFDRQELQRNVISSSSFKLFLELEPQVRDIIFKFYESKYASCLKMLDEMKDNLLLDMYLAPHVRTLYTQIRNRALIQYFSPYVSADMHRMAAAFNTTVAALEDELTQLILEGLISARVDSHSKILYARDVDQRSTTFEKSLLMGKEFQRRAKAMMLRAAVLRNQIH 461

[Close]

BLAST of COP9 signalosome complex subunit 1 vs. Ensembl Celegans
Match: csn-1 (COP9 signalosome complex subunit 1 [Source:UniProtKB/Swiss-Prot;Acc:Q9GS00])

HSP 1 Score: 142.895 bits (359), Expect = 3.835e-36
Identity = 107/460 (23.26%), Postives = 207/460 (45.00%), Query Frame = 1

Query:  124 VTETTLDLDTYINNYKDFGKYLRLIFIARRCRPLRLEALVIALDWLKQ-SWNFVEYCKVFNIIATVVRDSIEMADATLTTLIPGVCCRDDFNFQRFQTRVSYETIRLPDGRFLEFDSDWVDKTRRQSNQTIDQLDTDLKNYKANNMAESIRRGCDELASVHMKTGDLLSANKNYTRS-RDYCKTDMHELMMCFNVIKVSIYLTHWRHVSSYVDRAETLLENITNGCSSTGSQNRSISDEVSGSWKQSSNTEKVTSDQKDNRQKMK-ALLHCVVG--LVEMYERNFXXXXXXFLQADHDYVSFNSILTANDVALYGTICSLATFDRNALKSMVIQNSNFKMFLENEPTLRDILHNFYNFQYAECLKGMAQIKNQLLLDIYLADHVEYLYREIRNRALCQYFSPYQCADLNKIATCFNTSVPELLQELKPLISTGQLKAKIDSHNNLLLVTSISQQNQVFQR 1488
            V E+ +D+++   +Y     +LR  FIAR C  LR +A +  +++LK+ + +   Y   FN + +      E+A             R +F  ++   ++               D  W+++       T DQL  + K +K   + ES RR  ++L   +M  G +  A + Y+R  RDYC    H + M  N ++V+I    W  + +  + A   L++  +   ++    ++       +                NRQ ++ AL  C+    L+++  + ++      LQ   + +     +T++D+ +YG + ++AT  R  LK  V  N  F+  LE+EP L ++L ++ + ++  C + M  +K +LLLD +++ +V+ L+ +IR + + QY  PY    +  +A     S  EL   L  LI    +  KID +  ++ +     +N + +R
Sbjct:   79 VNESAIDIESLACSYDSNAFFLRARFIARHCPILRADAYISLINYLKEHTTDITHYVAFFNELES------ELA-------------RKEFKNRQLNFQIPLR------------DQKWIEENGATWQSTTDQLQAEYKRHKDEGVKESTRRAMEDLFQHYMMAGKIDEAIRLYSRGIRDYCTQLKHSINMWINWMEVAICANDWGKLDTVTNTAYRSLKDADDAEKNSQQSQQAPPQRGENAPYMVERDPNAPIQTLTNRQLIETALAKCLAAQVLLKLRNKRYSQVVETILQIKTECLQSKWFVTSSDLGIYGMLSAMATMSRADLKLQVSGNGTFRKLLESEPQLIELLGSYTSSRFGRCFEIMRSVKPRLLLDPFISRNVDELFEKIRQKCVLQYLQPYSTIKMATMAEAVGMSSAELQLSLLELIEQKHVSLKIDQNEGIVRILDERDENAILKR 507

[Close]

BLAST of COP9 signalosome complex subunit 1 vs. Ensembl Celegans
Match: rpn-7 (26S proteasome non-ATPase regulatory subunit 6 [Source:UniProtKB/Swiss-Prot;Acc:Q20585])

HSP 1 Score: 86.6557 bits (213), Expect = 4.875e-18
Identity = 77/347 (22.19%), Postives = 157/347 (45.24%), Query Frame = 1

Query:  466 DSDWVDKTRRQSNQTIDQLDTDLKNYKANNMAESIRRGCDELASVHMKTGDLLSANKNYTRSRDYCKTDMHELMMCFNVIKVSIYLTHWRHVSSYVDRAETLLENITNGCSSTGSQNRSISDEVSGSWKQSSNTEKVTSDQKDNRQKMKALLHCVVGLVEMYERNFXXXXXXFLQADHDYVSFNSILTANDVALYGTICSLATFDRNALKSMVIQNSNFKMFLENEP------TLRDILHNFYNFQYAECLKGMAQIKNQLL-LDIYLADHVEYLYREIRNRALCQYFSPYQCADLNKIATCFNTSVPELLQELKPLISTGQLKAKIDSHNNLLLVTSISQQNQVFQ 1485
            D+  +   +  + + ID++  ++++ + N     +R+G       + + GD  +A K YT + +      + + + F +I+V ++      ++ ++ +A+ L+E                     G W            ++ NR      L     L  M  R+FA AA  FL+A   + S+  ++T  ++ LY  I +    DR  L++ VI+ +  +  L           +R+ L ++Y+  Y      +A ++++    D YL+ H  Y  R +R+RA  Q+ +PY+   ++ +A  F  S   + +EL  LI+TGQL+ +ID+ N ++ V     +N +++
Sbjct:   80 DATQLAAMKAANQKKIDEITAEVEDAEKNLGESEVRQGLLRKFEYYCQIGDKDNALKAYTATYEKTVGMGYRIDVVFAMIRVGLFFLDHHLINKFITKAKELMEQ-------------------GGDW------------ERKNR------LRSYEALYRMSVRDFAGAADLFLEAVPTFGSY-ELMTYENLILYTVITTTFALDRPDLRTKVIRCNEVQEQLTGGGLNGTLIPVREYLESYYDCHYDRFFIQLAALESERFKFDRYLSPHFNYYSRGMRHRAYEQFLTPYKTVRIDMMAKDFGVSRAFIDRELHRLIATGQLQCRIDAVNGVIEVNHRDSKNHLYK 388

[Close]

BLAST of COP9 signalosome complex subunit 1 vs. Ensembl Fly
Match: CSN1b (gene:FBgn0027057 transcript:FBtr0075074)

HSP 1 Score: 300.442 bits (768), Expect = 3.827e-95
Identity = 152/369 (41.19%), Postives = 229/369 (62.06%), Query Frame = 1

Query:  463 FDSDWVDKTRRQSNQTIDQLDTDLKNYKANNMAESIRRGCDELASVHMKTGDLLSANKNYTRSRDYCKTDMHELMMCFNVIKVSIYLTHWRHVSSYVDRAETLLENITNGCSSTGSQNRSISDEVSGSWKQSSNTEKVTSDQKDNRQKMKALLHCVVGLVEMYERNFXXXXXXFLQADHDYVSFNSILTANDVALYGTICSLATFDRNALKSMVIQNSNFKMFLENEPTLRDILHNFYNFQYAECLKGMAQIKNQLLLDIYLADHVEYLYREIRNRALCQYFSPYQCADLNKIATCFNTSVPELLQELKPLISTGQLKAKIDSHNNLLLVTSISQQNQVFQRAFHLFNSYEKRFKATFVHNACIRSELY 1569
            +D+ WVD   +++   +++LD+DLKNYK+N++ ESIRRG D+LA  ++  GDL +A K Y+R+RDYC +  H + MC NVIKVSIYL +W HV SY+ +AE                  S  D   GS              K+   ++   L C  GL E+ ++ +  AA+ FL A+ D+  F  +++ ++VA+YG +C+LATFDR  LK +VI +++FK+FLE EP LRDI+  FY  +YA CL  + +I++ LL+D+Y+A HV  LY +IRNRAL QYFSPY  AD++K+A  FN+SV +L  E+  LI  GQ++A+IDSHN +L      Q+N  F+RA  +   Y++  +   +  A ++S ++
Sbjct:  158 YDAAWVDTKMKKAALKLEKLDSDLKNYKSNSIKESIRRGHDDLADHYLSCGDLTNALKCYSRARDYCTSGKHVVNMCLNVIKVSIYLQNWAHVMSYISKAE------------------STPDFAEGS--------------KEANAQVHTRLECAAGLAELQQKKYKVAAKHFLNANFDHCDFPEMISTSNVAVYGGLCALATFDRQELKRLVIASTSFKLFLELEPQLRDIIFKFYESKYASCLTLLDEIRDNLLVDMYIAPHVTTLYTKIRNRALIQYFSPYMSADMHKMAMAFNSSVGDLENEVMQLILDGQIQARIDSHNKILFAKEADQRNSTFERALIMGKQYQRHTRMLVLRAAMLKSHIH 494

[Close]

BLAST of COP9 signalosome complex subunit 1 vs. Ensembl Fly
Match: CSN1a (gene:FBgn0028838 transcript:FBtr0080671)

HSP 1 Score: 161.77 bits (408), Expect = 2.237e-44
Identity = 114/390 (29.23%), Postives = 187/390 (47.95%), Query Frame = 1

Query:  130 ETTLDLDTYINNYKDFGKYLRLIFIARRCRPLRLEALVIALDWLKQSWNFVEYCKVFNIIATVVRDSIEMADATLTTLIPGVCCRDDFNFQRFQTRVSYETIRLPDGRFL-EFDSDWVDKTRRQSNQTIDQLDTDLKNYKANNMAESIRRGCDELASVHMKTGDLLSANKNYTRSRDYCKTDMHELMMCFNVIKVSIYLTHWRHVSSYVDRAETLLENITNGCSSTGSQNRSISDEVSGSWKQSSNTEKVTSDQKDNRQKMKALLHCVVGLVEMYERNFXXXXXXFLQADHDYVSFNSILTANDVALYGTICSLATFDRNALKSMVIQNSNFKMFLENEPTLRDILHNFYNFQYAECLKGMAQIKNQLLLDIYLADHVEYLYREIRNRAL 1296
            ET L L +Y + Y D  + +RL FIA+ C  L + AL +AL+ +K ++N   Y +++  +   V       D        G       N +   T  S  +     GR +  +DS WV+    ++   + +LD +L   K+N+ +  +RR  +E+   H K+G+L  A K Y R+R YC +  + + M  N+I+VSIY+ +W HV +Y+D A+           + G +N +                          Q++ A L CV GL  +  + + +AA+ FL   +    ++ I+   DV LY  +C+LATFDR  L+   I +  FK F +  P +  IL  FY  ++  C+  + +I+N + LD+YL+ HV  LY  I  R L
Sbjct:    6 ETMLHLPSYADRYTDIPRLIRLKFIAQVCPELSVLALELALNHVKTTYNVKLYDELYKTLCVEV-------DRKYPNQSKG-------NEELHTTGGSEPSTSSGRGRVVVPYDSYWVEDNIMEATLMLQELDAELNFKKSNSGSSYVRRILEEIGDHHEKSGNLQMAVKFYARARPYCTSSENVINMFRNLIRVSIYMENWWHVLTYIDEAKQY---------AYGFENLA--------------------------QEVPARLSCVAGLAHLGLKIYKSAAQYFLSTPYGRYDYDKIVAPEDVTLYAGLCALATFDRETLQLNAINSEAFKPFFQLSPKMWTILAKFYAGEFDACMTLLREIENHVRLDVYLSPHVSALYDLIMARML 346

[Close]

BLAST of COP9 signalosome complex subunit 1 vs. Ensembl Fly
Match: Rpn7 (gene:FBgn0028688 transcript:FBtr0084294)

HSP 1 Score: 85.8853 bits (211), Expect = 1.103e-17
Identity = 73/340 (21.47%), Postives = 139/340 (40.88%), Query Frame = 1

Query:  466 DSDWVDKTRRQSNQTIDQLDTDLKNYKANNMAESIRRGCDELASVHMKTGDLLSANKNYTRSRDYCKTDMHELMMCFNVIKVSIYLTHWRHVSSYVDRAETLLENITNGCSSTGSQNRSISDEVSGSWKQSSNTEKVTSDQKDNRQKMKALLHCVVGLVEMYERNFXXXXXXFLQADHDYVSFNSILTANDVALYGTICSLATFDRNALKSMVIQNSNFKMFLENEPTLRDILHNFYNFQYAECLKGMAQIKNQLLLDIYLADHVEYLYREIRNRALCQYFSPYQCADLNKIATCFNTSVPELLQELKPLISTGQLKAKIDSHNNLLLVTSISQQNQVFQ 1485
            D D + + +  +   ++QLD  +++ + N     +R    + +    + GD  +A   + ++ +   +  H L + F++I++ ++      ++  +D+A+ L+E                     G W              D R ++K       G+  +  R+F AAA  FL     + S+  ++       Y    ++    RN L+  VI+ S  +  L   P ++  L + YN QY      +A ++ QL LD  +  H  Y  RE+R     Q    Y+   L  +A  F  +V  + QEL   I+ G+L AK+D    ++       +N  +Q
Sbjct:   66 DKDLLARMKENNRVEVEQLDAAIEDAEKNLGEMEVREANLKKSEYLCRIGDKAAAETAFRKTYEKTVSLGHRLDIVFHLIRLGLFYLDHDLITRNIDKAKYLIEE-------------------GGDW--------------DRRNRLK----VYQGVYSVAVRDFKAAATFFLDTVSTFTSY-ELMDYPTFVRYTVYVAMIALPRNELRDKVIKGSEIQEVLHGLPDVKQFLFSLYNCQYENFYVHLAGVEKQLRLDYLIHPHYRYYVREMRILGYTQLLESYRSLTLQYMAESFGVTVEYIDQELARFIAAGRLHAKVDRVGGIVETNRPDNKNWQYQ 367

[Close]

BLAST of COP9 signalosome complex subunit 1 vs. Ensembl Zebrafish
Match: gps1 (G protein pathway suppressor 1 [Source:ZFIN;Acc:ZDB-GENE-041111-240])

HSP 1 Score: 327.02 bits (837), Expect = 1.010e-105
Identity = 188/516 (36.43%), Postives = 290/516 (56.20%), Query Frame = 1

Query:   28 IFCKMSMIEHMQLDLIEEDETISLLNDSPLQEVTETTLDLDTYINNYKDFGKYLRLIFIARRCRPLRLEALVIALDWLKQSWNFVEYCKVFNIIATVVRDSIEMADATLTTLIPGVCCRDDFNFQRFQTRVSYETIRLPDGRF--LEFDSDWVDKTRRQSNQTIDQLDTDLKNYKANNMAESIRRGCDELASVHMKTGDLLSANKNYTRSRDYCKTDMHELMMCFNVIKVSIYLTHWRHVSSYVDRAETLLENITNGCSSTGSQNRSISDEVSGSWKQSSNTEKVTSDQKDNRQKMKALLHCVVGLVEMYERNFXXXXXXFLQADHDYVSFNSILTANDVALYGTICSLATFDRNALKSMVIQNSNFKMFLENEPTLRDILHNFYNFQYAECLKGMAQIKNQLLLDIYLADHVEYLYREIRNRALCQYFSPYQCADLNKIATCFNTSVPELLQELKPLISTGQLKAKIDSHNNLLLVTSISQQNQVFQRAFHLFNSYEKRFKATFVHNACIRSELY 1569
            +F     +E MQ+D   +++  +  + + +  V   TLDL+ Y ++Y    +  RL FIA  C  LR+EAL +AL ++++++N   Y ++   +    R+   + DA                              +P+G       D+ W + TR+++   +++LDTDLKNYK N++ ESIRRG D+L   ++  GDL +A K Y+R+RDYC +  H + MC NVIKVS+YL +W HV SYV +AE+  E I        SQN+++  +                            L C  GL E+  R +  AA+ FLQA  D+  F  +L+ ++VA+YG +C+LATFDR  L+  VI +S+FK+FLE EP +RDI+  FY  +YA CLK + ++K+ LLLD+YLA HV  LY +IRNRAL QYFSPY  AD+NK+A  FNT+V  L  EL  LI  G + A+IDSH+ +L    + Q++  F+++  +   +++R KA  +  A +R++++
Sbjct:    7 VFNFQGSVEPMQIDADPQEDQQNAPDTNYV--VENPTLDLEQYASSYSGLMRIERLQFIADHCPQLRVEALKMALSFVQRTFNVDVYEEIHRKLTEATREVQGVPDA------------------------------VPEGAVEPPPLDTAWAESTRKKALLKLEKLDTDLKNYKGNSIKESIRRGHDDLGDHYLDCGDLSNALKCYSRARDYCTSAKHVINMCLNVIKVSVYLQNWSHVLSYVSKAESTPE-IAEQRGERDSQNQAVLTK----------------------------LKCAAGLAELASRKYKPAAKCFLQASFDHCDFPELLSPSNVAVYGGLCALATFDRQELQRNVISSSSFKLFLELEPQVRDIIFKFYESKYASCLKMLDEMKDNLLLDMYLAPHVRTLYTQIRNRALIQYFSPYVSADMNKMAVAFNTTVAALEDELTQLILEGLINARIDSHSKILYARDVDQRSTTFEKSLQMGKEFQRRAKAMILRAAVLRNQIH 461

[Close]

BLAST of COP9 signalosome complex subunit 1 vs. Ensembl Zebrafish
Match: gps1 (G protein pathway suppressor 1 [Source:ZFIN;Acc:ZDB-GENE-041111-240])

HSP 1 Score: 325.479 bits (833), Expect = 5.076e-105
Identity = 187/514 (36.38%), Postives = 288/514 (56.03%), Query Frame = 1

Query:   28 IFCKMSMIEHMQLDLIEEDETISLLNDSPLQEVTETTLDLDTYINNYKDFGKYLRLIFIARRCRPLRLEALVIALDWLKQSWNFVEYCKVFNIIATVVRDSIEMADATLTTLIPGVCCRDDFNFQRFQTRVSYETIRLPDGRFLEFDSDWVDKTRRQSNQTIDQLDTDLKNYKANNMAESIRRGCDELASVHMKTGDLLSANKNYTRSRDYCKTDMHELMMCFNVIKVSIYLTHWRHVSSYVDRAETLLENITNGCSSTGSQNRSISDEVSGSWKQSSNTEKVTSDQKDNRQKMKALLHCVVGLVEMYERNFXXXXXXFLQADHDYVSFNSILTANDVALYGTICSLATFDRNALKSMVIQNSNFKMFLENEPTLRDILHNFYNFQYAECLKGMAQIKNQLLLDIYLADHVEYLYREIRNRALCQYFSPYQCADLNKIATCFNTSVPELLQELKPLISTGQLKAKIDSHNNLLLVTSISQQNQVFQRAFHLFNSYEKRFKATFVHNACIRSELY 1569
            +F     +E MQ+D   +++  +  + + +  V   TLDL+ Y ++Y    +  RL FIA  C  LR+EAL +AL ++++++N   Y ++   +    R  +E+                    Q     V    +  P       D+ W + TR+++   +++LDTDLKNYK N++ ESIRRG D+L   ++  GDL +A K Y+R+RDYC +  H + MC NVIKVS+YL +W HV SYV +AE+  E I        SQN+++  +                            L C  G  E+  R +  AA+ FLQA  D+  F  +L+ ++VA+YG +C+LATFDR  L+  VI +S+FK+FLE EP +RDI+  FY  +YA CLK + ++K+ LLLD+YLA HV  LY +IRNRAL QYFSPY  AD+NK+A  FNT+V  L  EL  LI  G + A+IDSH+ +L    + Q++  F+++  +   +++R KA  +  A +R++++
Sbjct:    7 VFNFQGSVEPMQIDADPQEDQQNAPDTNYV--VENPTLDLEQYASSYSGLMRIERLQFIADHCPQLRVEALKMALSFVQRTFNVDVYEEIHRKLTEATRQFLEV--------------------QGVPDAVPEGAVEPP-----PLDTAWAESTRKKALLKLEKLDTDLKNYKGNSIKESIRRGHDDLGDHYLDCGDLSNALKCYSRARDYCTSAKHVINMCLNVIKVSVYLQNWSHVLSYVSKAESTPE-IAEQRGERDSQNQAVLTK----------------------------LKCAAGKAELASRKYKPAAKCFLQASFDHCDFPELLSPSNVAVYGGLCALATFDRQELQRNVISSSSFKLFLELEPQVRDIIFKFYESKYASCLKMLDEMKDNLLLDMYLAPHVRTLYTQIRNRALIQYFSPYVSADMNKMAVAFNTTVAALEDELTQLILEGLINARIDSHSKILYARDVDQRSTTFEKSLQMGKEFQRRAKAMILRAAVLRNQIH 464

[Close]

BLAST of COP9 signalosome complex subunit 1 vs. Ensembl Zebrafish
Match: gps1 (G protein pathway suppressor 1 [Source:ZFIN;Acc:ZDB-GENE-041111-240])

HSP 1 Score: 315.464 bits (807), Expect = 5.258e-101
Identity = 188/537 (35.01%), Postives = 290/537 (54.00%), Query Frame = 1

Query:   28 IFCKMSMIEHMQLDLIEEDETISLLNDSPLQEVTETTLDLDTYINNYKDFGKYLRLIFIARRCRPLRLEALVIALDWLKQSWNFVEYCKVFNIIATVVRDSIEMADATLTTLIPGVCCRDDFNFQRFQTRVSYETIRLPDGRF--LEFDSDWVDKTRRQSNQTIDQLDTDLKNYKANNMAESIRRGCDELASVHMKTGDLLSANKNYTRSRDYCKTDMHELMMCFNVIKVSIYLTHWRHVSSYVDRAETLLENITNGCSSTGSQNRSISDEVSGSWKQSSNTEKVTSDQKDNRQKMKALLHCVVGLVEMYERNFXXXXXXFLQADHDYVSFNSILTANDVALYGTICSLATFDRNALKSMVIQNSNFKMFLENEPTLRDILHNFYNFQYAECLKGMAQIKNQLLLDIYLADHVEYLYREIRNRALCQYFSPYQCADLNKIATCFNTSVPELLQELKPLISTGQLKAKIDSHN---------------------NLLLVTSISQQNQVFQRAFHLFNSYEKRFKATFVHNACIRSELY 1569
            +F     +E MQ+D   +++  +  + + +  V   TLDL+ Y ++Y    +  RL FIA  C  LR+EAL +AL ++++++N   Y ++   +    R+   + DA                              +P+G       D+ W + TR+++   +++LDTDLKNYK N++ ESIRRG D+L   ++  GDL +A K Y+R+RDYC +  H + MC NVIKVS+YL +W HV SYV +AE+  E I        SQN+++  +                            L C  GL E+  R +  AA+ FLQA  D+  F  +L+ ++VA+YG +C+LATFDR  L+  VI +S+FK+FLE EP +RDI+  FY  +YA CLK + ++K+ LLLD+YLA HV  LY +IRNRAL QYFSPY  AD+NK+A  FNT+V  L  EL  LI  G + A+IDSH+                      +L    + Q++  F+++  +   +++R KA  +  A +R++++
Sbjct:    7 VFNFQGSVEPMQIDADPQEDQQNAPDTNYV--VENPTLDLEQYASSYSGLMRIERLQFIADHCPQLRVEALKMALSFVQRTFNVDVYEEIHRKLTEATREVQGVPDA------------------------------VPEGAVEPPPLDTAWAESTRKKALLKLEKLDTDLKNYKGNSIKESIRRGHDDLGDHYLDCGDLSNALKCYSRARDYCTSAKHVINMCLNVIKVSVYLQNWSHVLSYVSKAESTPE-IAEQRGERDSQNQAVLTK----------------------------LKCAAGLAELASRKYKPAAKCFLQASFDHCDFPELLSPSNVAVYGGLCALATFDRQELQRNVISSSSFKLFLELEPQVRDIIFKFYESKYASCLKMLDEMKDNLLLDMYLAPHVRTLYTQIRNRALIQYFSPYVSADMNKMAVAFNTTVAALEDELTQLILEGLINARIDSHSKEIRQMGSASHNLERSSDMRKKILYARDVDQRSTTFEKSLQMGKEFQRRAKAMILRAAVLRNQIH 482

[Close]

BLAST of COP9 signalosome complex subunit 1 vs. Ensembl Zebrafish
Match: psmd6 (proteasome 26S subunit, non-ATPase 6 [Source:ZFIN;Acc:ZDB-GENE-040426-1038])

HSP 1 Score: 81.6481 bits (200), Expect = 3.297e-16
Identity = 76/340 (22.35%), Postives = 138/340 (40.59%), Query Frame = 1

Query:  466 DSDWVDKTRRQSNQTIDQLDTDLKNYKANNMAESIRRGCDELASVHMKTGDLLSANKNYTRSRDYCKTDMHELMMCFNVIKVSIYLTHWRHVSSYVDRAETLLENITNGCSSTGSQNRSISDEVSGSWKQSSNTEKVTSDQKDNRQKMKALLHCVVGLVEMYERNFXXXXXXFLQADHDYVSFNSILTANDVALYGTICSLATFDRNALKSMVIQNSNFKMFLENEPTLRDILHNFYNFQYAECLKGMAQIKNQLLLDIYLADHVEYLYREIRNRALCQYFSPYQCADLNKIATCFNTSVPELLQELKPLISTGQLKAKIDSHNNLLLVTSISQQNQVFQ 1485
            DSD + K ++ +   + +LD  L++ + N     IR      A   ++ GD   A   + ++ D      H L + F ++++ ++      ++   ++A++L+E                     G W             + NR K+   L+CV        R+F  AA  FL     + S+  +     V     +C +A   R  L+  VI+ +     L + P +R  L + Y  +Y+   + +A+++ ++  D   A H  Y  RE+R  A  Q    Y+   L  +A  F  S   + QEL   I+ G+L  KID  N ++       +N  +Q
Sbjct:   63 DSDLLSKMKKANEDELKRLDDVLEDAEKNLGESEIRDAMMAKAEYLIRIGDKEGALTAFRKTYDKTVALGHRLDIVFYLLRIGLFYMDNDLITRNTEKAKSLIEE-------------------GGDW------------DRRNRLKVYQGLYCVAI------RDFKQAAELFLDTVSTFTSYELMDYKTFVTYTVYVCMIA-LKRPDLREKVIKGAEILEVLHSLPAVRQYLFSLYECRYSVFFQSLARVEQEMKQDWLFAPHYRYYVREMRILAYSQLLESYRSLTLGYMAEAFGVSTEFIDQELSRFIAAGRLHCKIDKVNEIVETNRPDSKNWQYQ 364

[Close]

BLAST of COP9 signalosome complex subunit 1 vs. Ensembl Xenopus
Match: gps1 (G protein pathway suppressor 1 [Source:NCBI gene;Acc:493337])

HSP 1 Score: 327.405 bits (838), Expect = 8.192e-105
Identity = 191/511 (37.38%), Postives = 292/511 (57.14%), Query Frame = 1

Query:   43 SMIEHMQLDLIEEDETISLLNDSPLQEVTETTLDLDTYINNYKDFGKYLRLIFIARRCRPLRLEALVIALDWLKQSWNFVEYCKVFNIIATVVRDSIEMADATLTTLIPGVCCRDDFNFQRFQTRVSYETIRLPDGRF--LEFDSDWVDKTRRQSNQTIDQLDTDLKNYKANNMAESIRRGCDELASVHMKTGDLLSANKNYTRSRDYCKTDMHELMMCFNVIKVSIYLTHWRHVSSYVDRAETLLENITNGCSSTGSQNRSISDEVSGSWKQSSNTEKVTSDQKDNRQKMKALLHCVVGLVEMYERNFXXXXXXFLQADHDYVSFNSILTANDVALYGTICSLATFDRNALKSMVIQNSNFKMFLENEPTLRDILHNFYNFQYAECLKGMAQIKNQLLLDIYLADHVEYLYREIRNRALCQYFSPYQCADLNKIATCFNTSVPELLQELKPLISTGQLKAKIDSHNNLLLVTSISQQNQVFQRAFHLFNSYEKRFKATFVHNACIRSELY 1569
            S +E MQ+D   +D+  ++ + S +  V   TLDL+ Y ++Y    +  RL FIA RC  LR+EAL +AL ++++++N   Y  +   +    R+     DA                              +P+G       D+ WV+ TR+++   +++LDTDLKNYK N++ ESIRRG D+L   ++  GDL +A K Y+R+RDYC +  H + MC NVIKVS+YL +W HV SYV +AE+  E               I+++     ++ S T+ V +            L C  GL E+  R +  AA+ FL A  D+  F  +L+ ++VA+YG +C+LATFDR  L+  VI +S+FK+FLE EP +RDI+  FY  +YA CLK + ++K+ LLLD+YLA HV  LY +IRNRAL QYFSPY  AD+ K+AT FNT+V  L  EL  LI  G + A+IDSH+ +L    + Q++  F+++  +   +++R KA  +  A +R++++
Sbjct:   85 SAVEPMQIDADPQDDQQNVPDVSYV--VENPTLDLEQYASSYSGLMRIERLQFIADRCPQLRVEALKMALSFVQRTFNVDVYEDIHRKLTEASREVQNAPDA------------------------------VPEGSMEPPPLDTTWVEATRKKALLKLEKLDTDLKNYKGNSIKESIRRGHDDLGDHYLDCGDLSNALKCYSRARDYCTSAKHVINMCLNVIKVSVYLQNWSHVLSYVSKAESTPE---------------IAEQ---RGERDSQTQSVLTK-----------LKCAAGLAELAARKYKQAAKCFLLASFDHCDFPELLSPSNVAVYGGLCALATFDRQELQRNVISSSSFKLFLELEPQVRDIIFKFYESKYASCLKMLDEMKDNLLLDMYLAPHVRTLYTQIRNRALIQYFSPYVSADMFKMATAFNTTVSALEDELTQLILEGLINARIDSHSKILYARDVDQRSTTFEKSLQMGREFQRRAKAMILRAAVLRNQIH 534

[Close]

BLAST of COP9 signalosome complex subunit 1 vs. Ensembl Xenopus
Match: gps1 (G protein pathway suppressor 1 [Source:NCBI gene;Acc:493337])

HSP 1 Score: 289.656 bits (740), Expect = 1.338e-90
Identity = 180/516 (34.88%), Postives = 280/516 (54.26%), Query Frame = 1

Query:   43 SMIEHMQLDLIEEDETISLLNDSPLQEVTETTLDLDTYINNYKDFGKYLRLIFIARRCRPLRLEALVIALDWLKQSWNFVEYCKVFNIIATVVRDSIEMADATLTTLIPGVCCRDDFNFQRFQTRVSYETIRLPDGRF--LEFDSDWVDKTRRQSNQTIDQLDTDLKNYKANNMAESIRR-----GCDELASVHMKTGDLLSANKNYTRSRDYCKTDMHELMMCFNVIKVSIYLTHWRHVSSYVDRAETLLENITNGCSSTGSQNRSISDEVSGSWKQSSNTEKVTSDQKDNRQKMKALLHCVVGLVEMYERNFXXXXXXFLQADHDYVSFNSILTANDVALYGTICSLATFDRNALKSMVIQNSNFKMFLENEPTLRDILHNFYNFQYAECLKGMAQIKNQLLLDIYLADHVEYLYREIRNRALCQYFSPYQCADLNKIATCFNTSVPELLQELKPLISTGQLKAKIDSHNNLLLVTSISQQNQVFQRAFHLFNSYEKRFKATFVHNACIRSELY 1569
            S +E MQ+D   +D+  ++ + S +  V   TLDL+ Y ++Y    +  RL FIA RC  LR+EAL +AL ++++++N   Y  +   +    R+     DA                              +P+G       D+ WV+ TR+++   +++LDTDLKNYK N++ ESIR      G D+L   ++  GDL +A K Y+R+RDYC +  H + MC NVIKV      ++  S++                +  S   S  +      ++ S T+ V +            L C  GL E+  R +  AA+ FL A  D+  F  +L+ ++VA+YG +C+LATFDR  L+  VI +S+FK+FLE EP +RDI+  FY  +YA CLK + ++K+ LLLD+YLA HV  LY +IRNRAL QYFSPY  AD+ K+AT FNT+V  L  EL  LI  G + A+IDSH+ +L    + Q++  F+++  +   +++R KA  +  A +R++++
Sbjct:   52 SAVEPMQIDADPQDDQQNVPDVSYV--VENPTLDLEQYASSYSGLMRIERLQFIADRCPQLRVEALKMALSFVQRTFNVDVYEDIHRKLTEASREVQNAPDA------------------------------VPEGSMEPPPLDTTWVEATRKKALLKLEKLDTDLKNYKGNSIKESIRYVHSILGHDDLGDHYLDCGDLSNALKCYSRARDYCTSAKHVINMCLNVIKV------FKIDSAF----------------AIQSHTESTPEIAEQRGERDSQTQSVLTK-----------LKCAAGLAELAARKYKQAAKCFLLASFDHCDFPELLSPSNVAVYGGLCALATFDRQELQRNVISSSSFKLFLELEPQVRDIIFKFYESKYASCLKMLDEMKDNLLLDMYLAPHVRTLYTQIRNRALIQYFSPYVSADMFKMATAFNTTVSALEDELTQLILEGLINARIDSHSKILYARDVDQRSTTFEKSLQMGREFQRRAKAMILRAAVLRNQIH 502

[Close]

BLAST of COP9 signalosome complex subunit 1 vs. Ensembl Xenopus
Match: gps1 (G protein pathway suppressor 1 [Source:NCBI gene;Acc:493337])

HSP 1 Score: 285.804 bits (730), Expect = 6.863e-90
Identity = 178/511 (34.83%), Postives = 277/511 (54.21%), Query Frame = 1

Query:   58 MQLDLIEEDETISLLNDSPLQEVTETTLDLDTYINNYKDFGKYLRLIFIARRCRPLRLEALVIALDWLKQSWNFVEYCKVFNIIATVVRDSIEMADATLTTLIPGVCCRDDFNFQRFQTRVSYETIRLPDGRF--LEFDSDWVDKTRRQSNQTIDQLDTDLKNYKANNMAESIRR-----GCDELASVHMKTGDLLSANKNYTRSRDYCKTDMHELMMCFNVIKVSIYLTHWRHVSSYVDRAETLLENITNGCSSTGSQNRSISDEVSGSWKQSSNTEKVTSDQKDNRQKMKALLHCVVGLVEMYERNFXXXXXXFLQADHDYVSFNSILTANDVALYGTICSLATFDRNALKSMVIQNSNFKMFLENEPTLRDILHNFYNFQYAECLKGMAQIKNQLLLDIYLADHVEYLYREIRNRALCQYFSPYQCADLNKIATCFNTSVPELLQELKPLISTGQLKAKIDSHNNLLLVTSISQQNQVFQRAFHLFNSYEKRFKATFVHNACIRSELY 1569
            MQ+D   +D+  ++ + S +  V   TLDL+ Y ++Y    +  RL FIA RC  LR+EAL +AL ++++++N   Y  +   +    R+     DA                              +P+G       D+ WV+ TR+++   +++LDTDLKNYK N++ ESIR      G D+L   ++  GDL +A K Y+R+RDYC +  H + MC NVIKV      ++  S++                +  S   S  +      ++ S T+ V +            L C  GL E+  R +  AA+ FL A  D+  F  +L+ ++VA+YG +C+LATFDR  L+  VI +S+FK+FLE EP +RDI+  FY  +YA CLK + ++K+ LLLD+YLA HV  LY +IRNRAL QYFSPY  AD+ K+AT FNT+V  L  EL  LI  G + A+IDSH+ +L    + Q++  F+++  +   +++R KA  +  A +R++++
Sbjct:    1 MQIDADPQDDQQNVPDVSYV--VENPTLDLEQYASSYSGLMRIERLQFIADRCPQLRVEALKMALSFVQRTFNVDVYEDIHRKLTEASREVQNAPDA------------------------------VPEGSMEPPPLDTTWVEATRKKALLKLEKLDTDLKNYKGNSIKESIRYVHSILGHDDLGDHYLDCGDLSNALKCYSRARDYCTSAKHVINMCLNVIKV------FKIDSAF----------------AIQSHTESTPEIAEQRGERDSQTQSVLTK-----------LKCAAGLAELAARKYKQAAKCFLLASFDHCDFPELLSPSNVAVYGGLCALATFDRQELQRNVISSSSFKLFLELEPQVRDIIFKFYESKYASCLKMLDEMKDNLLLDMYLAPHVRTLYTQIRNRALIQYFSPYVSADMFKMATAFNTTVSALEDELTQLILEGLINARIDSHSKILYARDVDQRSTTFEKSLQMGREFQRRAKAMILRAAVLRNQIH 446

[Close]

BLAST of COP9 signalosome complex subunit 1 vs. Ensembl Xenopus
Match: psmd9 (proteasome 26S subunit, non-ATPase 9 [Source:Xenbase;Acc:XB-GENE-5727784])

HSP 1 Score: 89.3521 bits (220), Expect = 2.003e-18
Identity = 77/340 (22.65%), Postives = 138/340 (40.59%), Query Frame = 1

Query:  466 DSDWVDKTRRQSNQTIDQLDTDLKNYKANNMAESIRRGCDELASVHMKTGDLLSANKNYTRSRDYCKTDMHELMMCFNVIKVSIYLTHWRHVSSYVDRAETLLENITNGCSSTGSQNRSISDEVSGSWKQSSNTEKVTSDQKDNRQKMKALLHCVVGLVEMYERNFXXXXXXFLQADHDYVSFNSILTANDVALYGTICSLATFDRNALKSMVIQNSNFKMFLENEPTLRDILHNFYNFQYAECLKGMAQIKNQLLLDIYLADHVEYLYREIRNRALCQYFSPYQCADLNKIATCFNTSVPELLQELKPLISTGQLKAKIDSHNNLLLVTSISQQNQVFQ 1485
            D D ++K ++ + + + +LD +L++ + N     IR      A    + GD   A   + ++ D      H L + F ++++ ++      ++   ++A +L+E                     G W             + NR K+   L+CV        R+F  AA  FL     + S+  ++       Y    S+   DR  L+  VI+ +     L + PT+R  L + Y  +Y    + +A ++ +L  D   A H  Y  RE+R +A  Q    Y+   L  +A  F   V  + QEL   I+ G+L  KID  N ++       +N  +Q
Sbjct:  110 DMDLLNKMKKANEEELKRLDDELEDAEKNLGESEIRDAMMARAEYLCRIGDKEGALTAFRKTYDKTVALGHRLDIVFYLLRIGLFYMDNDLITRNTEKARSLIEE-------------------GGDW------------DRRNRLKVYQGLYCVAI------RDFKQAADLFLDTVSTFTSYE-LMDYKTFVTYTVYVSMIALDRPDLREKVIKGAEILEVLHSLPTVRQYLFSLYECRYGVFFQSLAAVEQELKKDWLFASHYRYYVREMRIQAYGQLLESYRSLTLGYMAEAFGVGVEFIDQELSRFIAAGRLHCKIDKVNEIVETNRPDSKNWQYQ 411

[Close]

BLAST of COP9 signalosome complex subunit 1 vs. Ensembl Mouse
Match: Gps1 (G protein pathway suppressor 1 [Source:MGI Symbol;Acc:MGI:2384801])

HSP 1 Score: 330.102 bits (845), Expect = 6.410e-107
Identity = 188/515 (36.50%), Postives = 292/515 (56.70%), Query Frame = 1

Query:   28 IFCKMSMIEHMQLDLIEEDETISLLNDSPLQEVTE-TTLDLDTYINNYKDFGKYLRLIFIARRCRPLRLEALVIALDWLKQSWNFVEYCKVFNIIATVVRDSIEMADATLTTLIPGVCCRDDFNFQRFQTRVSYETIRLPDGRFLEFDSDWVDKTRRQSNQTIDQLDTDLKNYKANNMAESIRRGCDELASVHMKTGDLLSANKNYTRSRDYCKTDMHELMMCFNVIKVSIYLTHWRHVSSYVDRAETLLENITNGCSSTGSQNRSISDEVSGSWKQSSNTEKVTSDQKDNRQKMKALLHCVVGLVEMYERNFXXXXXXFLQADHDYVSFNSILTANDVALYGTICSLATFDRNALKSMVIQNSNFKMFLENEPTLRDILHNFYNFQYAECLKGMAQIKNQLLLDIYLADHVEYLYREIRNRALCQYFSPYQCADLNKIATCFNTSVPELLQELKPLISTGQLKAKIDSHNNLLLVTSISQQNQVFQRAFHLFNSYEKRFKATFVHNACIRSELY 1569
            +F     +E MQ+D+  +++     N   +  V E  TLDL+ Y  +Y    +  RL FIA RC PLR+EAL +AL ++++++N   Y ++   ++   R+     DA                       +    +  P       D+ WV+ TR+++   +++LDTDLKNYK N++ ESIRRG D+L   ++  GDL +A K Y+R+RDYC +  H + MC NVIKVS+YL +W HV SYV +AE+                   + E++   ++ S T+ + +            L C  GL E+  R +  AA+ FL A  D+  F  +L+ ++VA+YG +C+LATFDR  L+  VI +S+FK+FLE EP +RDI+  FY  +YA CLK + ++K+ LLLD+YLA HV  LY +IRNRAL QYFSPY  AD++K+A  FNT+V  L  EL  LI  G + A+IDSH+ +L    + Q++  F+++  +   +++R KA  +  A +R++++
Sbjct:    7 VFNLQGAVEPMQIDVDPQEDP---QNAPDVNYVVENPTLDLEQYAASYSGLMRIERLQFIADRCPPLRVEALKMALSFVQRTFNVDMYEEIHRKLSEATRELQNAPDA-----------------------IPESGVEPP-----PLDTAWVEATRKKALLKLEKLDTDLKNYKGNSIKESIRRGHDDLGDHYLDCGDLSNALKCYSRARDYCTSAKHVINMCLNVIKVSVYLQNWSHVLSYVSKAES-------------------TPEIAERGERDSQTQAILTK-----------LKCAAGLAELAARKYKQAAKCFLLASFDHCDFPELLSPSNVAVYGGLCALATFDRQELQRNVISSSSFKLFLELEPQVRDIIFKFYESKYASCLKMLDEMKDNLLLDMYLAPHVRTLYTQIRNRALIQYFSPYVSADMHKMAAAFNTTVAALEDELTQLILEGLINARIDSHSKILYARDVDQRSTTFEKSLLMGKEFQRRAKAMILRAAVLRNQIH 460

[Close]

BLAST of COP9 signalosome complex subunit 1 vs. Ensembl Mouse
Match: Gps1 (G protein pathway suppressor 1 [Source:MGI Symbol;Acc:MGI:2384801])

HSP 1 Score: 328.946 bits (842), Expect = 2.305e-106
Identity = 191/520 (36.73%), Postives = 291/520 (55.96%), Query Frame = 1

Query:   28 IFCKMSMIEHMQLDLIEEDETISLLNDSPLQEVTE-TTLDLDTYINNYKDFGKYLRLIFIARRCRPLRLEALVIALDWLKQSWNFVEYCKVFNIIATVVRDSIEMADATLTTLIPGVCCRDDFNFQRFQTRVSYETIRLPDGRFLEFDSDWVDKTRRQSNQTIDQLDTDLKNYKANNMAESIRRGCDELASVHMKTGDLLSANKNYTRSRDYCKTDMHELMMCFNVIKVSIYLTHWRHVSSYVDRAETLLENITNGCSSTGSQNRSISDEVSGSWKQSSNTEKVTSDQKDNRQKMKALLHCVVGLVEMYERNFXXXXXXFLQADHDYVSFNSILTANDVALYGTICSLATFDRNALKSMVIQNSNFKMFLENEPTLRDILHNFYNFQYAECLKGMAQIKNQLLLDIYLADHVEYLYREIRNRALCQYFSPYQCADLNKIATCFNTSVPELLQELKPLISTGQLKAKIDSHNNLLLVTSISQQNQVFQRAFHLFNSYEKRFKATFVHNACIRSELYQNVNT 1584
            +F     +E MQ+D+  +++     N   +  V E  TLDL+ Y  +Y    +  RL FIA RC PLR+EAL +AL ++++++N   Y ++   ++   R+     DA                       +    +  P       D+ WV+ TR+++   +++LDTDLKNYK N++ ESIRRG D+L   ++  GDL +A K Y+R+RDYC +  H + MC NVIKVS+YL +W HV SYV +AE+  E I        SQ ++I  +                            L C  GL E+  R +  AA+ FL A  D+  F  +L+ ++VA+YG +C+LATFDR  L+  VI +S+FK+FLE EP +RDI+  FY  +YA CLK + ++K+ LLLD+YLA HV  LY +IRNRAL QYFSPY  AD++K+A  FNT+V  L  EL  LI  G + A+IDSH+ +L    + Q++  F+++  +   +++R KA  +  A +R++++  V +
Sbjct:    7 VFNLQGAVEPMQIDVDPQEDP---QNAPDVNYVVENPTLDLEQYAASYSGLMRIERLQFIADRCPPLRVEALKMALSFVQRTFNVDMYEEIHRKLSEATRELQNAPDA-----------------------IPESGVEPP-----PLDTAWVEATRKKALLKLEKLDTDLKNYKGNSIKESIRRGHDDLGDHYLDCGDLSNALKCYSRARDYCTSAKHVINMCLNVIKVSVYLQNWSHVLSYVSKAESTPE-IAEQRGERDSQTQAILTK----------------------------LKCAAGLAELAARKYKQAAKCFLLASFDHCDFPELLSPSNVAVYGGLCALATFDRQELQRNVISSSSFKLFLELEPQVRDIIFKFYESKYASCLKMLDEMKDNLLLDMYLAPHVRTLYTQIRNRALIQYFSPYVSADMHKMAAAFNTTVAALEDELTQLILEGLINARIDSHSKILYARDVDQRSTTFEKSLLMGKEFQRRAKAMILRAAVLRNQIHVKVKS 466

[Close]

BLAST of COP9 signalosome complex subunit 1 vs. Ensembl Mouse
Match: Gps1 (G protein pathway suppressor 1 [Source:MGI Symbol;Acc:MGI:2384801])

HSP 1 Score: 327.405 bits (838), Expect = 8.072e-106
Identity = 190/515 (36.89%), Postives = 289/515 (56.12%), Query Frame = 1

Query:   28 IFCKMSMIEHMQLDLIEEDETISLLNDSPLQEVTE-TTLDLDTYINNYKDFGKYLRLIFIARRCRPLRLEALVIALDWLKQSWNFVEYCKVFNIIATVVRDSIEMADATLTTLIPGVCCRDDFNFQRFQTRVSYETIRLPDGRFLEFDSDWVDKTRRQSNQTIDQLDTDLKNYKANNMAESIRRGCDELASVHMKTGDLLSANKNYTRSRDYCKTDMHELMMCFNVIKVSIYLTHWRHVSSYVDRAETLLENITNGCSSTGSQNRSISDEVSGSWKQSSNTEKVTSDQKDNRQKMKALLHCVVGLVEMYERNFXXXXXXFLQADHDYVSFNSILTANDVALYGTICSLATFDRNALKSMVIQNSNFKMFLENEPTLRDILHNFYNFQYAECLKGMAQIKNQLLLDIYLADHVEYLYREIRNRALCQYFSPYQCADLNKIATCFNTSVPELLQELKPLISTGQLKAKIDSHNNLLLVTSISQQNQVFQRAFHLFNSYEKRFKATFVHNACIRSELY 1569
            +F     +E MQ+D+  +++     N   +  V E  TLDL+ Y  +Y    +  RL FIA RC PLR+EAL +AL ++++++N   Y ++   ++   R+     DA                       +    +  P       D+ WV+ TR+++   +++LDTDLKNYK N++ ESIRRG D+L   ++  GDL +A K Y+R+RDYC +  H + MC NVIKVS+YL +W HV SYV +AE+  E I        SQ ++I  +                            L C  GL E+  R +  AA+ FL A  D+  F  +L+ ++VA+YG +C+LATFDR  L+  VI +S+FK+FLE EP +RDI+  FY  +YA CLK + ++K+ LLLD+YLA HV  LY +IRNRAL QYFSPY  AD++K+A  FNT+V  L  EL  LI  G + A+IDSH+ +L    + Q++  F+++  +   +++R KA  +  A +R++++
Sbjct:    7 VFNLQGAVEPMQIDVDPQEDP---QNAPDVNYVVENPTLDLEQYAASYSGLMRIERLQFIADRCPPLRVEALKMALSFVQRTFNVDMYEEIHRKLSEATRELQNAPDA-----------------------IPESGVEPP-----PLDTAWVEATRKKALLKLEKLDTDLKNYKGNSIKESIRRGHDDLGDHYLDCGDLSNALKCYSRARDYCTSAKHVINMCLNVIKVSVYLQNWSHVLSYVSKAESTPE-IAEQRGERDSQTQAILTK----------------------------LKCAAGLAELAARKYKQAAKCFLLASFDHCDFPELLSPSNVAVYGGLCALATFDRQELQRNVISSSSFKLFLELEPQVRDIIFKFYESKYASCLKMLDEMKDNLLLDMYLAPHVRTLYTQIRNRALIQYFSPYVSADMHKMAAAFNTTVAALEDELTQLILEGLINARIDSHSKILYARDVDQRSTTFEKSLLMGKEFQRRAKAMILRAAVLRNQIH 461

[Close]

BLAST of COP9 signalosome complex subunit 1 vs. Ensembl Mouse
Match: Gps1 (G protein pathway suppressor 1 [Source:MGI Symbol;Acc:MGI:2384801])

HSP 1 Score: 327.405 bits (838), Expect = 2.736e-105
Identity = 188/508 (37.01%), Postives = 291/508 (57.28%), Query Frame = 1

Query:   49 IEHMQLDLIEEDETISLLNDSPLQEVTE-TTLDLDTYINNYKDFGKYLRLIFIARRCRPLRLEALVIALDWLKQSWNFVEYCKVFNIIATVVRDSIEMADATLTTLIPGVCCRDDFNFQRFQTRVSYETIRLPDGRFLEFDSDWVDKTRRQSNQTIDQLDTDLKNYKANNMAESIRRGCDELASVHMKTGDLLSANKNYTRSRDYCKTDMHELMMCFNVIKVSIYLTHWRHVSSYVDRAETLLENITNGCSSTGSQNRSISDEVSGSWKQSSNTEKVTSDQKDNRQKMKALLHCVVGLVEMYERNFXXXXXXFLQADHDYVSFNSILTANDVALYGTICSLATFDRNALKSMVIQNSNFKMFLENEPTLRDILHNFYNFQYAECLKGMAQIKNQLLLDIYLADHVEYLYREIRNRALCQYFSPYQCADLNKIATCFNTSVPELLQELKPLISTGQLKAKIDSHNNLLLVTSISQQNQVFQRAFHLFNSYEKRFKATFVHNACIRSELY 1569
            +E MQ+D+  +++     N   +  V E  TLDL+ Y  +Y    +  RL FIA RC PLR+EAL +AL ++++++N   Y ++   ++   R+     DA                       +    +  P       D+ WV+ TR+++   +++LDTDLKNYK N++ ESIRRG D+L   ++  GDL +A K Y+R+RDYC +  H + MC NVIKVS+YL +W HV SYV +AE+  E               I+++     ++ S T+ + +            L C  GL E+  R +  AA+ FL A  D+  F  +L+ ++VA+YG +C+LATFDR  L+  VI +S+FK+FLE EP +RDI+  FY  +YA CLK + ++K+ LLLD+YLA HV  LY +IRNRAL QYFSPY  AD++K+A  FNT+V  L  EL  LI  G + A+IDSH+ +L    + Q++  F+++  +   +++R KA  +  A +R++++
Sbjct:   53 VEPMQIDVDPQEDP---QNAPDVNYVVENPTLDLEQYAASYSGLMRIERLQFIADRCPPLRVEALKMALSFVQRTFNVDMYEEIHRKLSEATRELQNAPDA-----------------------IPESGVEPP-----PLDTAWVEATRKKALLKLEKLDTDLKNYKGNSIKESIRRGHDDLGDHYLDCGDLSNALKCYSRARDYCTSAKHVINMCLNVIKVSVYLQNWSHVLSYVSKAESTPE---------------IAEQ---RGERDSQTQAILTK-----------LKCAAGLAELAARKYKQAAKCFLLASFDHCDFPELLSPSNVAVYGGLCALATFDRQELQRNVISSSSFKLFLELEPQVRDIIFKFYESKYASCLKMLDEMKDNLLLDMYLAPHVRTLYTQIRNRALIQYFSPYVSADMHKMAAAFNTTVAALEDELTQLILEGLINARIDSHSKILYARDVDQRSTTFEKSLLMGKEFQRRAKAMILRAAVLRNQIH 500

[Close]

BLAST of COP9 signalosome complex subunit 1 vs. Ensembl Mouse
Match: Psmd6 (proteasome (prosome, macropain) 26S subunit, non-ATPase, 6 [Source:MGI Symbol;Acc:MGI:1913663])

HSP 1 Score: 83.5741 bits (205), Expect = 7.430e-17
Identity = 74/342 (21.64%), Postives = 138/342 (40.35%), Query Frame = 1

Query:  460 EFDSDWVDKTRRQSNQTIDQLDTDLKNYKANNMAESIRRGCDELASVHMKTGDLLSANKNYTRSRDYCKTDMHELMMCFNVIKVSIYLTHWRHVSSYVDRAETLLENITNGCSSTGSQNRSISDEVSGSWKQSSNTEKVTSDQKDNRQKMKALLHCVVGLVEMYERNFXXXXXXFLQADHDYVSFNSILTANDVALYGTICSLATFDRNALKSMVIQNSNFKMFLENEPTLRDILHNFYNFQYAECLKGMAQIKNQLLLDIYLADHVEYLYREIRNRALCQYFSPYQCADLNKIATCFNTSVPELLQELKPLISTGQLKAKIDSHNNLLLVTSISQQNQVFQ 1485
            + D D + K ++ + + + +LD +L++ + N     IR      A    + GD   A   + ++ D      H L + F ++++ ++      ++   ++A++L+E                     G W             + NR K+   L+CV        R+F  AA  FL     + S+  ++       Y    S+   +R  L+  VI+ +     L + P +R  L + Y  +Y+   + +A ++ ++  D   A H  Y  RE+R  A  Q    Y+   L  +A  F   V  + QEL   I+ G+L  KID  N ++       +N  +Q
Sbjct:   64 QMDVDLLSKMKKANEEELKRLDEELEDAEKNLGESEIRDAMMAKAEYLCQIGDKEGALTAFRKTYDKTVALGHRLDIVFYLLRIGLFYMDNDLITRNTEKAKSLIEE-------------------GGDW------------DRRNRLKVYQGLYCVAI------RDFKQAAELFLDTVSTFTSYE-LMDYKTFVTYTVYVSMIALERPDLREKVIKGAEILEVLHSLPAVRQYLFSLYECRYSVFFQSLAIVEQEMKKDWLFAPHYRYYVREMRIHAYSQLLESYRSLTLGYMAEAFGVGVDFIDQELSRFIAAGRLHCKIDKVNEIVETNRPDSKNWQYQ 367

[Close]

BLAST of COP9 signalosome complex subunit 1 vs. UniProt/SwissProt
Match: sp|Q6NRT5|CSN1_XENLA (COP9 signalosome complex subunit 1 OS=Xenopus laevis OX=8355 GN=csn1 PE=2 SV=1)

HSP 1 Score: 331.257 bits (848), Expect = 1.833e-106
Identity = 193/516 (37.40%), Postives = 295/516 (57.17%), Query Frame = 1

Query:   28 IFCKMSMIEHMQLDLIEEDETISLLNDSPLQEVTETTLDLDTYINNYKDFGKYLRLIFIARRCRPLRLEALVIALDWLKQSWNFVEYCKVFNIIATVVRDSIEMADATLTTLIPGVCCRDDFNFQRFQTRVSYETIRLPDGRF--LEFDSDWVDKTRRQSNQTIDQLDTDLKNYKANNMAESIRRGCDELASVHMKTGDLLSANKNYTRSRDYCKTDMHELMMCFNVIKVSIYLTHWRHVSSYVDRAETLLENITNGCSSTGSQNRSISDEVSGSWKQSSNTEKVTSDQKDNRQKMKALLHCVVGLVEMYERNFXXXXXXFLQADHDYVSFNSILTANDVALYGTICSLATFDRNALKSMVIQNSNFKMFLENEPTLRDILHNFYNFQYAECLKGMAQIKNQLLLDIYLADHVEYLYREIRNRALCQYFSPYQCADLNKIATCFNTSVPELLQELKPLISTGQLKAKIDSHNNLLLVTSISQQNQVFQRAFHLFNSYEKRFKATFVHNACIRSELY 1569
            +F   S +E MQ+D   +D+  ++ + + +  V   TLDL+ Y ++Y    +  RL FIA RC  LR+EAL +AL ++++++N   Y  +   +A   R+     DA                              +P+G       D+ WV+ TR+++   +++LDTDLKNYK N++ ESIRRG D+L   ++  GDL +A K Y+R+RDYC +  H + MC NVIKVS+YL +W HV SYV +AE+  E               I+++     ++ S T+ V +            L C  GL E+  R +  AA+ FL A  D+  F  +L+ ++VA+YG +C+LATFDR  L+  VI +S+FK+FLE EP +RDI+  FY  +YA CLK + +IK+ LLLD+YLA HV  LY +IRNRAL QYFSPY  AD+ K+AT FNT+V  L  EL  LI  G + A+IDSH+ +L    + Q++  F+++  +   +++R KA  +  A +R++++
Sbjct:    7 VFNLQSAVEPMQIDADPQDDQQNMPDVNYV--VENPTLDLEQYASSYSGLMRIERLQFIADRCPQLRVEALKMALSFVQRTFNVDVYEDIHRKLAEASREVQNAPDA------------------------------VPEGSMEPPALDTSWVEATRKKALLKLEKLDTDLKNYKGNSIKESIRRGHDDLGDHYLDCGDLSNALKCYSRARDYCTSAKHVINMCLNVIKVSVYLQNWSHVLSYVSKAESTPE---------------IAEQ---RGERDSQTQAVLTK-----------LKCAAGLAELAARKYKQAAKCFLLASFDHCDFPELLSPSNVAVYGGLCALATFDRQELQRNVISSSSFKLFLELEPQVRDIIFKFYESKYASCLKMLDEIKDNLLLDMYLAPHVRTLYTQIRNRALIQYFSPYVSADMYKMATAFNTTVSALEDELTQLILEGLINARIDSHSKILYARDVDQRSTTFEKSLQMGREFQRRAKAMILRAAVLRNQIH 461

[Close]

BLAST of COP9 signalosome complex subunit 1 vs. UniProt/SwissProt
Match: sp|Q99LD4|CSN1_MOUSE (COP9 signalosome complex subunit 1 OS=Mus musculus OX=10090 GN=Gps1 PE=1 SV=1)

HSP 1 Score: 324.709 bits (831), Expect = 4.411e-104
Identity = 183/482 (37.97%), Postives = 274/482 (56.85%), Query Frame = 1

Query:  124 VTETTLDLDTYINNYKDFGKYLRLIFIARRCRPLRLEALVIALDWLKQSWNFVEYCKVFNIIATVVRDSIEMADATLTTLIPGVCCRDDFNFQRFQTRVSYETIRLPDGRFLEFDSDWVDKTRRQSNQTIDQLDTDLKNYKANNMAESIRRGCDELASVHMKTGDLLSANKNYTRSRDYCKTDMHELMMCFNVIKVSIYLTHWRHVSSYVDRAETLLENITNGCSSTGSQNRSISDEVSGSWKQSSNTEKVTSDQKDNRQKMKALLHCVVGLVEMYERNFXXXXXXFLQADHDYVSFNSILTANDVALYGTICSLATFDRNALKSMVIQNSNFKMFLENEPTLRDILHNFYNFQYAECLKGMAQIKNQLLLDIYLADHVEYLYREIRNRALCQYFSPYQCADLNKIATCFNTSVPELLQELKPLISTGQLKAKIDSHNNLLLVTSISQQNQVFQRAFHLFNSYEKRFKATFVHNACIRSELY 1569
            V   TLDL+ Y  +Y    +  RL FIA RC PLR+EAL +AL ++++++N   Y ++   ++   R+     DA                       +    +  P       D+ WV+ TR+++   +++LDTDLKNYK N++ ESIRRG D+L   ++  GDL +A K Y+R+RDYC +  H + MC NVIKVS+YL +W HV SYV +AE+  E I        SQ ++I  +                            L C  GL E+  R +  AA+ FL A  D+  F  +L+ ++VA+YG +C+LATFDR  L+  VI +S+FK+FLE EP +RDI+  FY  +YA CLK + ++K+ LLLD+YLA HV  LY +IRNRAL QYFSPY  AD++K+A  FNT+V  L  EL  LI  G + A+IDSH+ +L    + Q++  F+++  +   +++R KA  +  A +R++++
Sbjct:   21 VENPTLDLEQYAASYSGLMRIERLQFIADRCPPLRVEALKMALSFVQRTFNVDMYEEIHRKLSEATRELQNAPDA-----------------------IPESGVEPP-----PLDTAWVEATRKKALLKLEKLDTDLKNYKGNSIKESIRRGHDDLGDHYLDCGDLSNALKCYSRARDYCTSAKHVINMCLNVIKVSVYLQNWSHVLSYVSKAESTPE-IAEQRGERDSQTQAILTK----------------------------LKCAAGLAELAARKYKQAAKCFLLASFDHCDFPELLSPSNVAVYGGLCALATFDRQELQRNVISSSSFKLFLELEPQVRDIIFKFYESKYASCLKMLDEMKDNLLLDMYLAPHVRTLYTQIRNRALIQYFSPYVSADMHKMAAAFNTTVAALEDELTQLILEGLINARIDSHSKILYARDVDQRSTTFEKSLLMGKEFQRRAKAMILRAAVLRNQIH 445

[Close]

BLAST of COP9 signalosome complex subunit 1 vs. UniProt/SwissProt
Match: sp|P97834|CSN1_RAT (COP9 signalosome complex subunit 1 OS=Rattus norvegicus OX=10116 GN=Gps1 PE=1 SV=1)

HSP 1 Score: 323.939 bits (829), Expect = 8.495e-104
Identity = 182/482 (37.76%), Postives = 274/482 (56.85%), Query Frame = 1

Query:  124 VTETTLDLDTYINNYKDFGKYLRLIFIARRCRPLRLEALVIALDWLKQSWNFVEYCKVFNIIATVVRDSIEMADATLTTLIPGVCCRDDFNFQRFQTRVSYETIRLPDGRFLEFDSDWVDKTRRQSNQTIDQLDTDLKNYKANNMAESIRRGCDELASVHMKTGDLLSANKNYTRSRDYCKTDMHELMMCFNVIKVSIYLTHWRHVSSYVDRAETLLENITNGCSSTGSQNRSISDEVSGSWKQSSNTEKVTSDQKDNRQKMKALLHCVVGLVEMYERNFXXXXXXFLQADHDYVSFNSILTANDVALYGTICSLATFDRNALKSMVIQNSNFKMFLENEPTLRDILHNFYNFQYAECLKGMAQIKNQLLLDIYLADHVEYLYREIRNRALCQYFSPYQCADLNKIATCFNTSVPELLQELKPLISTGQLKAKIDSHNNLLLVTSISQQNQVFQRAFHLFNSYEKRFKATFVHNACIRSELY 1569
            V   TLDL+ Y  +Y    +  RL FIA RC PLR+EAL +AL ++++++N   Y ++   ++   R+     DA                       +    +  P       D+ WV+ TR+++   +++LDTDLKNYK N++ ESIRRG D+L   ++  GDL +A K Y+R+RDYC +  H + MC NVIKVS+YL +W HV SYV +AE+  E I        SQ ++I  +                            L C  GL E+  R +  AA+ FL A  D+  F  +L+ ++VA+YG +C+LATFDR  L+  VI +S+FK+FLE EP +RDI+  FY  +YA CLK + ++K+ LLLD+YLA HV  LY +IRNRAL QYFSPY  AD++K+A  FNT+V  L  EL  +I  G + A+IDSH+ +L    + Q++  F+++  +   +++R KA  +  A +R++++
Sbjct:   21 VENPTLDLEQYAASYSGLMRIERLQFIADRCPPLRVEALKMALSFVQRTFNVDMYEEIHRKLSEATRELQNAPDA-----------------------IPESGVEPP-----PLDTAWVEATRKKALLKLEKLDTDLKNYKGNSIKESIRRGHDDLGDHYLDCGDLSNALKCYSRARDYCTSAKHVINMCLNVIKVSVYLQNWSHVLSYVSKAESTPE-IAEQRGERDSQTQAILTK----------------------------LKCAAGLAELAARKYKQAAKCFLLASFDHCDFPELLSPSNVAVYGGLCALATFDRQELQRNVISSSSFKLFLELEPQVRDIIFKFYESKYASCLKMLDEMKDNLLLDMYLAPHVRTLYTQIRNRALIQYFSPYVSADMHKMAAAFNTTVAALEDELTQVILEGLINARIDSHSKILYARDVDQRSTTFEKSLLMGKEFQRRAKAMILRAAVLRNQIH 445

[Close]

BLAST of COP9 signalosome complex subunit 1 vs. UniProt/SwissProt
Match: sp|Q13098|CSN1_HUMAN (COP9 signalosome complex subunit 1 OS=Homo sapiens OX=9606 GN=GPS1 PE=1 SV=4)

HSP 1 Score: 317.775 bits (813), Expect = 2.837e-101
Identity = 184/515 (35.73%), Postives = 286/515 (55.53%), Query Frame = 1

Query:   28 IFCKMSMIEHMQLDLIEEDETISLLNDSPLQEVTE-TTLDLDTYINNYKDFGKYLRLIFIARRCRPLRLEALVIALDWLKQSWNFVEYCKVFNIIATVVRDSIEMADATLTTLIPGVCCRDDFNFQRFQTRVSYETIRLPDGRFLEFDSDWVDKTRRQSNQTIDQLDTDLKNYKANNMAESIRRGCDELASVHMKTGDLLSANKNYTRSRDYCKTDMHELMMCFNVIKVSIYLTHWRHVSSYVDRAETLLENITNGCSSTGSQNRSISDEVSGSWKQSSNTEKVTSDQKDNRQKMKALLHCVVGLVEMYERNFXXXXXXFLQADHDYVSFNSILTANDVALYGTICSLATFDRNALKSMVIQNSNFKMFLENEPTLRDILHNFYNFQYAECLKGMAQIKNQLLLDIYLADHVEYLYREIRNRALCQYFSPYQCADLNKIATCFNTSVPELLQELKPLISTGQLKAKIDSHNNLLLVTSISQQNQVFQRAFHLFNSYEKRFKATFVHNACIRSELY 1569
            +F     +E MQ+D+  +++     N   +  V E  +LDL+ Y  +Y    +  RL FIA  C  LR+EAL +AL ++++++N   Y ++   ++   R S+                      Q     +    +  P       D+ WV+ TR+++   +++LDTDLKNYK N++ ESIRRG D+L   ++  GDL +A K Y+R+RDYC +  H + MC NVIKVS+YL +W HV SYV +AE+  E I        SQ ++I  +                            L C  GL E+  R +  AA+  L A  D+  F  +L+ ++VA+YG +C+LATFDR  L+  VI +S+FK+FLE EP +RDI+  FY  +YA CLK + ++K+ LLLD+YLA HV  LY +IRNRAL QYFSPY  AD++++A  FNT+V  L  EL  LI  G + A++DSH+ +L    + Q++  F+++  +   +++R KA  +  A +R++++
Sbjct:    7 VFNLQGAVEPMQIDVDPQEDP---QNAPDVNYVVENPSLDLEQYAASYSGLMRIERLQFIADHCPTLRVEALKMALSFVQRTFNVDMYEEIHRKLSEATRSSLR-------------------ELQNAPDAIPESGVEPP-----ALDTAWVEATRKKALLKLEKLDTDLKNYKGNSIKESIRRGHDDLGDHYLDCGDLSNALKCYSRARDYCTSAKHVINMCLNVIKVSVYLQNWSHVLSYVSKAESTPE-IAEQRGERDSQTQAILTK----------------------------LKCAAGLAELAARKYKQAAKCLLLASFDHCDFPELLSPSNVAIYGGLCALATFDRQELQRNVISSSSFKLFLELEPQVRDIIFKFYESKYASCLKMLDEMKDNLLLDMYLAPHVRTLYTQIRNRALIQYFSPYVSADMHRMAAAFNTTVAALEDELTQLILEGLISARVDSHSKILYARDVDQRSTTFEKSLLMGKEFQRRAKAMMLRAAVLRNQIH 465

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BLAST of COP9 signalosome complex subunit 1 vs. UniProt/SwissProt
Match: sp|Q9VVU5|CSN1_DROME (COP9 signalosome complex subunit 1b OS=Drosophila melanogaster OX=7227 GN=CSN1b PE=2 SV=1)

HSP 1 Score: 300.442 bits (768), Expect = 3.837e-94
Identity = 152/369 (41.19%), Postives = 229/369 (62.06%), Query Frame = 1

Query:  463 FDSDWVDKTRRQSNQTIDQLDTDLKNYKANNMAESIRRGCDELASVHMKTGDLLSANKNYTRSRDYCKTDMHELMMCFNVIKVSIYLTHWRHVSSYVDRAETLLENITNGCSSTGSQNRSISDEVSGSWKQSSNTEKVTSDQKDNRQKMKALLHCVVGLVEMYERNFXXXXXXFLQADHDYVSFNSILTANDVALYGTICSLATFDRNALKSMVIQNSNFKMFLENEPTLRDILHNFYNFQYAECLKGMAQIKNQLLLDIYLADHVEYLYREIRNRALCQYFSPYQCADLNKIATCFNTSVPELLQELKPLISTGQLKAKIDSHNNLLLVTSISQQNQVFQRAFHLFNSYEKRFKATFVHNACIRSELY 1569
            +D+ WVD   +++   +++LD+DLKNYK+N++ ESIRRG D+LA  ++  GDL +A K Y+R+RDYC +  H + MC NVIKVSIYL +W HV SY+ +AE                  S  D   GS              K+   ++   L C  GL E+ ++ +  AA+ FL A+ D+  F  +++ ++VA+YG +C+LATFDR  LK +VI +++FK+FLE EP LRDI+  FY  +YA CL  + +I++ LL+D+Y+A HV  LY +IRNRAL QYFSPY  AD++K+A  FN+SV +L  E+  LI  GQ++A+IDSHN +L      Q+N  F+RA  +   Y++  +   +  A ++S ++
Sbjct:  158 YDAAWVDTKMKKAALKLEKLDSDLKNYKSNSIKESIRRGHDDLADHYLSCGDLTNALKCYSRARDYCTSGKHVVNMCLNVIKVSIYLQNWAHVMSYISKAE------------------STPDFAEGS--------------KEANAQVHTRLECAAGLAELQQKKYKVAAKHFLNANFDHCDFPEMISTSNVAVYGGLCALATFDRQELKRLVIASTSFKLFLELEPQLRDIIFKFYESKYASCLTLLDEIRDNLLVDMYIAPHVTTLYTKIRNRALIQYFSPYMSADMHKMAMAFNSSVGDLENEVMQLILDGQIQARIDSHNKILFAKEADQRNSTFERALIMGKQYQRHTRMLVLRAAMLKSHIH 494

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BLAST of COP9 signalosome complex subunit 1 vs. TrEMBL
Match: R7UZX3 (PCI domain-containing protein OS=Capitella teleta OX=283909 GN=CAPTEDRAFT_174845 PE=4 SV=1)

HSP 1 Score: 354.755 bits (909), Expect = 2.516e-113
Identity = 195/498 (39.16%), Postives = 297/498 (59.64%), Query Frame = 1

Query:   58 MQLDLI-EEDETISLLNDSPLQEVTETTLDLDTYINNYKDFGKYLRLIFIARRCRPLRLEALVIALDWLKQSWNFVEYCKVFNIIATVVRDSIEMADATLTTLIPGVCCRDDFNFQRFQTRVSYETIRLPDGRFLEFDSDWVDKTRRQSNQTIDQLDTDLKNYKANNMAESIRRGCDELASVHMKTGDLLSANKNYTRSRDYCKTDMHELMMCFNVIKVSIYLTHWRHVSSYVDRAETLLENITNGCSSTGSQNRSISDEVSGSWKQSSNTEKVTSDQKDNRQKMKALLHCVVGLVEMYERNFXXXXXXFLQADHDYVSFNSILTANDVALYGTICSLATFDRNALKSMVIQNSNFKMFLENEPTLRDILHNFYNFQYAECLKGMAQIKNQLLLDIYLADHVEYLYREIRNRALCQYFSPYQCADLNKIATCFNTSVPELLQELKPLISTGQLKAKIDSHNNLLLVTSISQQNQVFQRAFHLFNSYEKRFKATFVHNA 1548
            MQ+D + EE++ + + +      V  T LDL+TY  +Y+   K  RL+F+A  C PLR+EAL +AL  +  ++N      ++  I   ++D+I    + L   + G+                     +P       D+ W++ T +++   +++LDTDLKNYK+N++ ESIRRG D+L   ++  GDL +A K Y+R+RDYC +  H + MC NVIKVS+YL +W HV SYV++AE+  +               +S++++                KD+ Q +   L C  GL E+  + + +AA+ FLQA+ D+  F  +++AN+VA+YG +C+LA+FDR  L+  VI +S+FK+FLE EP LRDILH FY+ +YA CLK + QIK+ LLLD+YLA HV  LY +IRNRALCQYFSPY  AD+N++A+ FNT+V  L  EL  LI  GQ+ A+IDSHN +L   +  Q+N  F+++  +   Y++R KA  + +A
Sbjct:    1 MQVDGVQEENDNVEVAH----HLVENTNLDLETYAGSYRGLAKLHRLLFVAEHCPPLRVEALRMALSHVMTTYN----SNMYQEIHKSLQDAITGRQSILPDTLVGI------------------VHNVP-----SLDTQWIESTAKKAALKLEKLDTDLKNYKSNSIKESIRRGHDDLGDHYLDCGDLSNALKCYSRARDYCTSAKHVVNMCLNVIKVSVYLQNWSHVLSYVNKAESTPQ---------------VSEQLN----------------KDSGQAVVTRLKCAAGLAELATKKYKSAAKYFLQANFDHCEFPELISANNVAMYGALCALASFDRQELQKHVISSSSFKLFLELEPQLRDILHQFYDSKYASCLKLLHQIKDNLLLDLYLAPHVSALYTQIRNRALCQYFSPYASADMNRMASAFNTTVSALEDELMLLILDGQINARIDSHNKILYAKNDDQRNSTFEKSVAMGVDYQRRSKALILRSA 436

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BLAST of COP9 signalosome complex subunit 1 vs. TrEMBL
Match: K1RS36 (COP9 signalosome complex subunit 1 OS=Crassostrea gigas OX=29159 GN=CGI_10020637 PE=4 SV=1)

HSP 1 Score: 351.288 bits (900), Expect = 4.158e-112
Identity = 193/503 (38.37%), Postives = 281/503 (55.86%), Query Frame = 1

Query:   67 DLIEEDETISLLNDSPLQEVTETTLDLDTYINNYKDFGKYLRLIFIARRCRPLRLEALVIALDWLKQSWNFVEYCKVFNIIATVVRDSIEMADATLTTL--IPGVCCRDDFNFQRFQTRVSYETIRLPDGRFLEFDSDWVDKTRRQSNQTIDQLDTDLKNYKANNMAESIRRGCDELASVHMKTGDLLSANKNYTRSRDYCKTDMHELMMCFNVIKVSIYLTHWRHVSSYVDRAETLLENITNGCSSTGSQNRSISDEVSGSWKQSSNTEKVTSDQKDNRQKMKALLHCVVGLVEMYERNFXXXXXXFLQADHDYVSFNSILTANDVALYGTICSLATFDRNALKSMVIQNSNFKMFLENEPTLRDILHNFYNFQYAECLKGMAQIKNQLLLDIYLADHVEYLYREIRNRALCQYFSPYQCADLNKIATCFNTSVPELLQELKPLISTGQLKAKIDSHNNLLLVTSISQQNQVFQRAFHLFNSYEKRFKATFVHNACIRSELY 1569
            D +EED  +          V  TTLDL+ Y   Y    K  RL+FIA  C  LR+EAL +AL ++  ++N   Y ++   +   V  S  + DA    +  +P +                              D+ W++ T +++   +++LDTDLKNYK+N++ ESIRRG D+L   ++  GDL +A K Y+R+RDYC +  H + MC NVIKVS+YL +W HV SYV++AE                               S  E      KD  Q +   L C  GL ++  + + +AA+ FLQA+ DY  F  +L+  +VA YG +C+LA+FDR  L+  VI +S+FK+FLE EP LRDI+H FY  +YA CLK + +IK+ LLLD+YLA HV  LY +IRNRALCQYFSPY  AD+ K+A  FNT+VP L  E+  LI  GQ+ A+IDSHN +L      Q++  F+++F +   Y++R KA  + +A +R++++
Sbjct:   11 DNVEEDRYV----------VENTTLDLEQYAAQYSGLAKLNRLLFIADHCPMLRVEALRMALAYVMNTYNTSLYQQIHRKLQEAVTSSSSLPDAVAGAIHNVPSL------------------------------DTQWIETTSKKAALKLEKLDTDLKNYKSNSIKESIRRGHDDLGDHYLDYGDLSNALKCYSRARDYCTSPKHVVNMCLNVIKVSVYLQNWSHVQSYVNKAE-------------------------------STPEMAEQHGKDGGQIVLTKLKCAAGLADLATKKYKSAAKYFLQANFDYCDFPELLSPCNVATYGALCALASFDRQELQKNVISSSSFKLFLELEPQLRDIIHKFYESKYASCLKLLGEIKDNLLLDMYLAPHVNVLYTQIRNRALCQYFSPYLSADMRKMAEAFNTTVPALEDEIMQLILDGQVNARIDSHNKILYAKDTDQRSSTFEKSFAMGKEYQRRTKALILRSAMLRNQIH 442

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BLAST of COP9 signalosome complex subunit 1 vs. TrEMBL
Match: V3Z109 (PCI domain-containing protein OS=Lottia gigantea OX=225164 GN=LOTGIDRAFT_184282 PE=4 SV=1)

HSP 1 Score: 348.591 bits (893), Expect = 7.875e-111
Identity = 191/509 (37.52%), Postives = 294/509 (57.76%), Query Frame = 1

Query:   43 SMIEHMQLDLIEEDETISLLNDSPLQEVTETTLDLDTYINNYKDFGKYLRLIFIARRCRPLRLEALVIALDWLKQSWNFVEYCKVFNIIATVVRDSIEMADATLTTLIPGVCCRDDFNFQRFQTRVSYETIRLPDGRFLEFDSDWVDKTRRQSNQTIDQLDTDLKNYKANNMAESIRRGCDELASVHMKTGDLLSANKNYTRSRDYCKTDMHELMMCFNVIKVSIYLTHWRHVSSYVDRAETLLENITNGCSSTGSQNRSISDEVSGSWKQSSNTEKVTSDQKDNRQKMKALLHCVVGLVEMYERNFXXXXXXFLQADHDYVSFNSILTANDVALYGTICSLATFDRNALKSMVIQNSNFKMFLENEPTLRDILHNFYNFQYAECLKGMAQIKNQLLLDIYLADHVEYLYREIRNRALCQYFSPYQCADLNKIATCFNTSVPELLQELKPLISTGQLKAKIDSHNNLLLVTSISQQNQVFQRAFHLFNSYEKRFKATFVHNACIRSELY 1569
            S +E MQ+D I+E+   +  + + +  V   TLDL+ Y   Y    K  RL+F+A  C  LR+EAL +AL +   ++N      ++ +I    +++I     T ++++P                V+   +  P       D+ W++ T +++   +++LDTDLKNYK+N++ ESIRRG D+L   ++  GDL +A K Y+R+RDYC    H + MC NVIKVS+YL +W HV SYV++AE                                 T + T   K+  Q ++  L C  GL ++    + +AA+ FLQ+  D+  F  +++ ++V  YG++C+LATFDR  L+  VI +S FK FLE EP LRDILH F+  +YA CLK + +IK+ LLLD+YLA H+  LY +IRNRALCQYFSPY  AD+ K+A+ FNT++P L  EL  LI  GQ+KA+IDSHN +L    I ++++ F++A  +   Y++R KA  + +A IR++++
Sbjct:   12 SAVEPMQVDAIQEENDNTEASHNYV--VENPTLDLEQYSAQYTGLAKLHRLMFVADHCPSLRVEALRMALSYSMTTYN----ANLYQVIHQKTQEAI-----TASSVLPDA--------------VAGAILNTP-----ALDTQWIETTAKKAALKLEKLDTDLKNYKSNSIKESIRRGHDDLGDHYLDCGDLSNALKCYSRARDYCTNPKHVVNMCLNVIKVSVYLQNWSHVQSYVNKAEA--------------------------------TPEATEHGKNGGQAIQTKLKCAAGLADLATCKYKSAAKYFLQSSFDHCDFPELISPSNVTTYGSLCALATFDRQELQKNVITSSTFKQFLELEPQLRDILHRFHESKYASCLKLLGEIKDNLLLDMYLAPHINTLYTQIRNRALCQYFSPYLSADMRKMASAFNTTLPALEDELMQLILEGQIKARIDSHNKILYAKDIDERSRTFEKAVAMGKEYQRRSKALVLRSAVIRNQIH 458

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BLAST of COP9 signalosome complex subunit 1 vs. TrEMBL
Match: A0A210QT24 (COP9 signalosome complex subunit 1 OS=Mizuhopecten yessoensis OX=6573 GN=KP79_PYT05670 PE=4 SV=1)

HSP 1 Score: 348.591 bits (893), Expect = 8.690e-111
Identity = 196/508 (38.58%), Postives = 289/508 (56.89%), Query Frame = 1

Query:   49 IEHMQLDL-IEEDETISLLNDSPLQEVTETTLDLDTYINNYKDFGKYLRLIFIARRCRPLRLEALVIALDWLKQSWNFVEYCKVFNIIATVVRDSIEMADATLTTLIPGVCCRDDFNFQRFQTRVSYETIRLPDGRFLEFDSDWVDKTRRQSNQTIDQLDTDLKNYKANNMAESIRRGCDELASVHMKTGDLLSANKNYTRSRDYCKTDMHELMMCFNVIKVSIYLTHWRHVSSYVDRAETLLENITNGCSSTGSQNRSISDEVSGSWKQSSNTEKVTSDQKDNRQKMKALLHCVVGLVEMYERNFXXXXXXFLQADHDYVSFNSILTANDVALYGTICSLATFDRNALKSMVIQNSNFKMFLENEPTLRDILHNFYNFQYAECLKGMAQIKNQLLLDIYLADHVEYLYREIRNRALCQYFSPYQCADLNKIATCFNTSVPELLQELKPLISTGQLKAKIDSHNNLLLVTSISQQNQVFQRAFHLFNSYEKRFKATFVHNACIRSELY 1569
            +E MQ+D   EE++ +    DS  Q V  T+LDL+ Y + Y    +  R +FIA  C  LR+EAL +AL ++  ++N   Y ++   +   V  S  + DA     + GV                     +P       D+ W++ T +++   +++LDTDLKNYK+N++ ESIRRG D+L   H+  GDL +A K Y+R+RDYC    H + MC NVIKVS+YL +W HV SYV++AE+  E   +G                                KD  Q +   L C  GL ++  + + +AA+ FL A+ D+  F  +L+A++VA YG  C+LA+FDR  L+  VI +S+FK+FLE EP LRDILH FY  +YA CLK + +IK+ LLLD+YLA HV  LY +IRNRALCQYFSPY  AD+ K+A  FNTSV  L  EL  LI  GQ+ A+IDSHN +L      Q++  F+++  +   Y++R +A  + +A ++++++
Sbjct:   14 VEPMQVDAQPEENDNV---EDSQYQ-VENTSLDLEQYASQYTGLARLKRQLFIAEHCPSLRVEALRMALSYVMTTYNTNLYQEIHRKLQEAVASSSSLPDA-----VAGV------------------VHNMP-----ALDTQWIETTAKKAALKLEKLDTDLKNYKSNSIKESIRRGHDDLGDHHLDCGDLSNALKCYSRARDYCTISKHVVNMCLNVIKVSVYLQNWSHVQSYVNKAESTPEMAEHG--------------------------------KDGGQAVLTKLKCAAGLADLATKKYKSAAKYFLLANFDFCDFPELLSASNVATYGVFCALASFDRQELQKNVISSSSFKLFLELEPQLRDILHKFYESKYASCLKLLGEIKDNLLLDMYLAPHVNVLYSQIRNRALCQYFSPYLSADMRKMAEAFNTSVGGLEDELMQLILEGQINARIDSHNKILYAKDTDQRSTTFEKSLTMGKEYQRRTRALILRSAILKNQIH 457

[Close]

BLAST of COP9 signalosome complex subunit 1 vs. TrEMBL
Match: A0A2T7PZD5 (PCI domain-containing protein OS=Pomacea canaliculata OX=400727 GN=C0Q70_01392 PE=4 SV=1)

HSP 1 Score: 344.739 bits (883), Expect = 3.011e-109
Identity = 194/508 (38.19%), Postives = 293/508 (57.68%), Query Frame = 1

Query:   49 IEHMQLD-LIEEDETISLLNDSPLQEVTETTLDLDTYINNYKDFGKYLRLIFIARRCRPLRLEALVIALDWLKQSWNFVEYCKVFNIIATVVRDSIEMADATLTTLIPGVCCRDDFNFQRFQTRVSYETIRLPDGRFLEFDSDWVDKTRRQSNQTIDQLDTDLKNYKANNMAESIRRGCDELASVHMKTGDLLSANKNYTRSRDYCKTDMHELMMCFNVIKVSIYLTHWRHVSSYVDRAETLLENITNGCSSTGSQNRSISDEVSGSWKQSSNTEKVTSDQKDNRQKMKALLHCVVGLVEMYERNFXXXXXXFLQADHDYVSFNSILTANDVALYGTICSLATFDRNALKSMVIQNSNFKMFLENEPTLRDILHNFYNFQYAECLKGMAQIKNQLLLDIYLADHVEYLYREIRNRALCQYFSPYQCADLNKIATCFNTSVPELLQELKPLISTGQLKAKIDSHNNLLLVTSISQQNQVFQRAFHLFNSYEKRFKATFVHNACIRSELY 1569
            +E MQ+D   EE++ +    + P   V   +LDL+ Y   Y    +  RL+FIA  C  LR+EAL +AL+++  ++N      ++ II   ++++     A L + +P                V+     +P       D  W++ T +++   +++LDTDLKNYK+N++ ESIRRG D+L   ++  GDL +A K Y+R+RDYC    H + MC NVIKVS+YL +W HV SYV++AE+  E  +   ++  +Q+R                                 L C  GL ++  R + +AA+ FLQ   D+  F  +L+ ++VA+YG +C+LA+FDR  L+  VI +S+FK FLE EP LRDILHNFY+ +YA CLK +A+I++ LLLD+YLA HV  LY +IRNRALCQYFSPY  AD+ K+A  FNTSV  L  EL  LI  GQ+ A+IDSHN +L      Q++  F+RA  +   Y++R KA  + +A ++++++
Sbjct:   13 VEPMQVDGAPEENDNV---EEEPQYTVENPSLDLEQYAAQYSGLARLNRLMFIADHCPSLRIEALRMALNYVLTTYN----TNLYGIIHRKLQEA-----AALNSGLPDA--------------VAGSVHSVP-----PLDVQWMETTAKKAAFKLEKLDTDLKNYKSNSIKESIRRGHDDLGDHYLDCGDLSNALKCYSRARDYCTNPKHVVNMCLNVIKVSVYLQNWSHVLSYVNKAESTPETESAKEANLTTQSR---------------------------------LKCAAGLADLATRKYKSAAKYFLQTSFDHCDFPELLSPSNVAMYGALCALASFDRQELQVNVISSSSFKQFLELEPQLRDILHNFYDSKYASCLKLLAEIRDNLLLDMYLAPHVSSLYTQIRNRALCQYFSPYLSADMRKMAAAFNTSVGALEDELMQLILDGQINARIDSHNKILYAKDTDQRSSTFERALAIGREYQRRTKALVLRSAVLKNQIH 456

[Close]

BLAST of COP9 signalosome complex subunit 1 vs. Ensembl Cavefish
Match: gps1 (G protein pathway suppressor 1 [Source:NCBI gene;Acc:103026457])

HSP 1 Score: 327.791 bits (839), Expect = 4.306e-106
Identity = 189/516 (36.63%), Postives = 290/516 (56.20%), Query Frame = 1

Query:   28 IFCKMSMIEHMQLDLIEEDETISLLNDSPLQEVTETTLDLDTYINNYKDFGKYLRLIFIARRCRPLRLEALVIALDWLKQSWNFVEYCKVFNIIATVVRDSIEMADATLTTLIPGVCCRDDFNFQRFQTRVSYETIRLPDGRF--LEFDSDWVDKTRRQSNQTIDQLDTDLKNYKANNMAESIRRGCDELASVHMKTGDLLSANKNYTRSRDYCKTDMHELMMCFNVIKVSIYLTHWRHVSSYVDRAETLLENITNGCSSTGSQNRSISDEVSGSWKQSSNTEKVTSDQKDNRQKMKALLHCVVGLVEMYERNFXXXXXXFLQADHDYVSFNSILTANDVALYGTICSLATFDRNALKSMVIQNSNFKMFLENEPTLRDILHNFYNFQYAECLKGMAQIKNQLLLDIYLADHVEYLYREIRNRALCQYFSPYQCADLNKIATCFNTSVPELLQELKPLISTGQLKAKIDSHNNLLLVTSISQQNQVFQRAFHLFNSYEKRFKATFVHNACIRSELY 1569
            +F     +E MQ+D   +++  +  + + +  V   TLDL+ Y ++Y    +  RL FIA  C  LR+EAL +AL ++++++N   Y ++   +    R+   + DA                              +P+G       D+ W + TR+++   +++LDTDLKNYK N++ ESIRRG D+L   ++  GDL +A K Y+R+RDYC +  H + MC NVIKVS+YL +W HV SYV +AE+  E I        SQN+S+  +                            L C  GL E+  R +  AA+ FLQA  D+  F  +L+ ++VA+YG +C+LATFDR  L+  VI +S+FK+FLE EP +RDI+  FY  +YA CLK + ++K+ LLLD+YLA HV  LY +IRNRAL QYFSPY  AD+NK+A  FNT+V  L  EL  LI  G + A+IDSH+ +L    + Q++  F+++  +   +++R KA  +  A +R++++
Sbjct:    7 VFNFQGSVEPMQIDADPQEDQQNAPDTNYV--VENPTLDLEQYASSYSGLMRIERLQFIADHCPQLRVEALKMALSFVQRTFNVDVYEEIHRKLTEATREVQGVPDA------------------------------VPEGAVEPPPLDTAWAESTRKKALLKLEKLDTDLKNYKGNSIKESIRRGHDDLGDHYLDCGDLSNALKCYSRARDYCTSAKHVINMCLNVIKVSVYLQNWSHVLSYVSKAESTPE-IAEQRGERDSQNQSVLTK----------------------------LKCAAGLAELASRKYKPAAKCFLQASFDHCDFPELLSPSNVAVYGGLCALATFDRQELQRNVISSSSFKLFLELEPQVRDIIFKFYESKYASCLKMLDEMKDNLLLDMYLAPHVRTLYTQIRNRALIQYFSPYVSADMNKMAIAFNTTVAALEDELTQLILEGLINARIDSHSKILYARDVDQRSTTFEKSLQMGKEFQRRAKAMILRAAVLRNQIH 461

[Close]

BLAST of COP9 signalosome complex subunit 1 vs. Ensembl Cavefish
Match: gps1 (G protein pathway suppressor 1 [Source:NCBI gene;Acc:103026457])

HSP 1 Score: 327.02 bits (837), Expect = 1.478e-105
Identity = 184/484 (38.02%), Postives = 275/484 (56.82%), Query Frame = 1

Query:  124 VTETTLDLDTYINNYKDFGKYLRLIFIARRCRPLRLEALVIALDWLKQSWNFVEYCKVFNIIATVVRDSIEMADATLTTLIPGVCCRDDFNFQRFQTRVSYETIRLPDGRF--LEFDSDWVDKTRRQSNQTIDQLDTDLKNYKANNMAESIRRGCDELASVHMKTGDLLSANKNYTRSRDYCKTDMHELMMCFNVIKVSIYLTHWRHVSSYVDRAETLLENITNGCSSTGSQNRSISDEVSGSWKQSSNTEKVTSDQKDNRQKMKALLHCVVGLVEMYERNFXXXXXXFLQADHDYVSFNSILTANDVALYGTICSLATFDRNALKSMVIQNSNFKMFLENEPTLRDILHNFYNFQYAECLKGMAQIKNQLLLDIYLADHVEYLYREIRNRALCQYFSPYQCADLNKIATCFNTSVPELLQELKPLISTGQLKAKIDSHNNLLLVTSISQQNQVFQRAFHLFNSYEKRFKATFVHNACIRSELY 1569
            V   TLDL+ Y ++Y    +  RL FIA  C  LR+EAL +AL ++++++N   Y ++   +    R+   + DA                              +P+G       D+ W + TR+++   +++LDTDLKNYK N++ ESIRRG D+L   ++  GDL +A K Y+R+RDYC +  H + MC NVIKVS+YL +W HV SYV +AE+  E I        SQN+S+  +                            L C  GL E+  R +  AA+ FLQA  D+  F  +L+ ++VA+YG +C+LATFDR  L+  VI +S+FK+FLE EP +RDI+  FY  +YA CLK + ++K+ LLLD+YLA HV  LY +IRNRAL QYFSPY  AD+NK+A  FNT+V  L  EL  LI  G + A+IDSH+ +L    + Q++  F+++  +   +++R KA  +  A +R++++
Sbjct:   58 VENPTLDLEQYASSYSGLMRIERLQFIADHCPQLRVEALKMALSFVQRTFNVDVYEEIHRKLTEATREVQGVPDA------------------------------VPEGAVEPPPLDTAWAESTRKKALLKLEKLDTDLKNYKGNSIKESIRRGHDDLGDHYLDCGDLSNALKCYSRARDYCTSAKHVINMCLNVIKVSVYLQNWSHVLSYVSKAESTPE-IAEQRGERDSQNQSVLTK----------------------------LKCAAGLAELASRKYKPAAKCFLQASFDHCDFPELLSPSNVAVYGGLCALATFDRQELQRNVISSSSFKLFLELEPQVRDIIFKFYESKYASCLKMLDEMKDNLLLDMYLAPHVRTLYTQIRNRALIQYFSPYVSADMNKMAIAFNTTVAALEDELTQLILEGLINARIDSHSKILYARDVDQRSTTFEKSLQMGKEFQRRAKAMILRAAVLRNQIH 482

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BLAST of COP9 signalosome complex subunit 1 vs. Ensembl Cavefish
Match: gps1 (G protein pathway suppressor 1 [Source:NCBI gene;Acc:103026457])

HSP 1 Score: 327.405 bits (838), Expect = 3.587e-105
Identity = 184/484 (38.02%), Postives = 275/484 (56.82%), Query Frame = 1

Query:  124 VTETTLDLDTYINNYKDFGKYLRLIFIARRCRPLRLEALVIALDWLKQSWNFVEYCKVFNIIATVVRDSIEMADATLTTLIPGVCCRDDFNFQRFQTRVSYETIRLPDGRF--LEFDSDWVDKTRRQSNQTIDQLDTDLKNYKANNMAESIRRGCDELASVHMKTGDLLSANKNYTRSRDYCKTDMHELMMCFNVIKVSIYLTHWRHVSSYVDRAETLLENITNGCSSTGSQNRSISDEVSGSWKQSSNTEKVTSDQKDNRQKMKALLHCVVGLVEMYERNFXXXXXXFLQADHDYVSFNSILTANDVALYGTICSLATFDRNALKSMVIQNSNFKMFLENEPTLRDILHNFYNFQYAECLKGMAQIKNQLLLDIYLADHVEYLYREIRNRALCQYFSPYQCADLNKIATCFNTSVPELLQELKPLISTGQLKAKIDSHNNLLLVTSISQQNQVFQRAFHLFNSYEKRFKATFVHNACIRSELY 1569
            V   TLDL+ Y ++Y    +  RL FIA  C  LR+EAL +AL ++++++N   Y ++   +    R+   + DA                              +P+G       D+ W + TR+++   +++LDTDLKNYK N++ ESIRRG D+L   ++  GDL +A K Y+R+RDYC +  H + MC NVIKVS+YL +W HV SYV +AE+  E I        SQN+S+  +                            L C  GL E+  R +  AA+ FLQA  D+  F  +L+ ++VA+YG +C+LATFDR  L+  VI +S+FK+FLE EP +RDI+  FY  +YA CLK + ++K+ LLLD+YLA HV  LY +IRNRAL QYFSPY  AD+NK+A  FNT+V  L  EL  LI  G + A+IDSH+ +L    + Q++  F+++  +   +++R KA  +  A +R++++
Sbjct:   95 VENPTLDLEQYASSYSGLMRIERLQFIADHCPQLRVEALKMALSFVQRTFNVDVYEEIHRKLTEATREVQGVPDA------------------------------VPEGAVEPPPLDTAWAESTRKKALLKLEKLDTDLKNYKGNSIKESIRRGHDDLGDHYLDCGDLSNALKCYSRARDYCTSAKHVINMCLNVIKVSVYLQNWSHVLSYVSKAESTPE-IAEQRGERDSQNQSVLTK----------------------------LKCAAGLAELASRKYKPAAKCFLQASFDHCDFPELLSPSNVAVYGGLCALATFDRQELQRNVISSSSFKLFLELEPQVRDIIFKFYESKYASCLKMLDEMKDNLLLDMYLAPHVRTLYTQIRNRALIQYFSPYVSADMNKMAIAFNTTVAALEDELTQLILEGLINARIDSHSKILYARDVDQRSTTFEKSLQMGKEFQRRAKAMILRAAVLRNQIH 519

[Close]

BLAST of COP9 signalosome complex subunit 1 vs. Ensembl Cavefish
Match: gps1 (G protein pathway suppressor 1 [Source:NCBI gene;Acc:103026457])

HSP 1 Score: 304.679 bits (779), Expect = 6.210e-97
Identity = 176/440 (40.00%), Postives = 250/440 (56.82%), Query Frame = 1

Query:  124 VTETTLDLDTYINNYKDFGKYLRLIFIARRCRPLRLEALVIALDWLKQSWNFVEYCKVFNIIATVVRDSIEMADATLTTLIPGVCCRDDFNFQRFQTRVSYETIRLPDGRF--LEFDSDWVDKTRRQSNQTIDQLDTDLKNYKANNMAESIRRGCDELASVHMKTGDLLSANKNYTRSRDYCKTDMHELMMCFNVIKVSIYLTHWRHVSSYVDRAETLLENITNGCSSTGSQNRSISDEVSGSWKQSSNTEKVTSDQKDNRQKMKALLHCVVGLVEMYERNFXXXXXXFLQADHDYVSFNSILTANDVALYGTICSLATFDRNALKSMVIQNSNFKMFLENEPTLRDILHNFYNFQYAECLKGMAQIKNQLLLDIYLADHVEYLYREIRNRALCQYFSPYQCADLNKIATCFNTSVPELLQELKPLISTGQLKAKIDSHN 1437
            V   TLDL+ Y ++Y    +  RL FIA  C  LR+EAL +AL ++++++N   Y ++   +    R+   + DA                              +P+G       D+ W + TR+++   +++LDTDLKNYK N++ ESIRRG D+L   ++  GDL +A K Y+R+RDYC +  H + MC NVIKVS+YL +W HV SYV +AE+  E I        SQN+S+  +                            L C  GL E+  R +  AA+ FLQA  D+  F  +L+ ++VA+YG +C+LATFDR  L+  VI +S+FK+FLE EP +RDI+  FY  +YA CLK + ++K+ LLLD+YLA HV  LY +IRNRAL QYFSPY  AD+NK+A  FNT+V  L  EL  LI  G + A+IDSH+
Sbjct:   95 VENPTLDLEQYASSYSGLMRIERLQFIADHCPQLRVEALKMALSFVQRTFNVDVYEEIHRKLTEATREVQGVPDA------------------------------VPEGAVEPPPLDTAWAESTRKKALLKLEKLDTDLKNYKGNSIKESIRRGHDDLGDHYLDCGDLSNALKCYSRARDYCTSAKHVINMCLNVIKVSVYLQNWSHVLSYVSKAESTPE-IAEQRGERDSQNQSVLTK----------------------------LKCAAGLAELASRKYKPAAKCFLQASFDHCDFPELLSPSNVAVYGGLCALATFDRQELQRNVISSSSFKLFLELEPQVRDIIFKFYESKYASCLKMLDEMKDNLLLDMYLAPHVRTLYTQIRNRALIQYFSPYVSADMNKMAIAFNTTVAALEDELTQLILEGLINARIDSHS 475

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BLAST of COP9 signalosome complex subunit 1 vs. Ensembl Cavefish
Match: psmd6 (proteasome 26S subunit, non-ATPase 6 [Source:ZFIN;Acc:ZDB-GENE-040426-1038])

HSP 1 Score: 80.4925 bits (197), Expect = 4.612e-16
Identity = 76/340 (22.35%), Postives = 137/340 (40.29%), Query Frame = 1

Query:  466 DSDWVDKTRRQSNQTIDQLDTDLKNYKANNMAESIRRGCDELASVHMKTGDLLSANKNYTRSRDYCKTDMHELMMCFNVIKVSIYLTHWRHVSSYVDRAETLLENITNGCSSTGSQNRSISDEVSGSWKQSSNTEKVTSDQKDNRQKMKALLHCVVGLVEMYERNFXXXXXXFLQADHDYVSFNSILTANDVALYGTICSLATFDRNALKSMVIQNSNFKMFLENEPTLRDILHNFYNFQYAECLKGMAQIKNQLLLDIYLADHVEYLYREIRNRALCQYFSPYQCADLNKIATCFNTSVPELLQELKPLISTGQLKAKIDSHNNLLLVTSISQQNQVFQ 1485
            DSD + K ++ +   + +LD  L++ + N     IR      A   ++ GD   A   + ++ D      H L + F ++++ ++      ++   ++A++L+E                     G W             + NR K+   L+CV        R+F  AA  FL     + S+  +     V     +C +A   R  L+  VI+ +     L + P +R  L + Y  +Y+   + +A+++  +  D   A H  Y  RE+R  A  Q    Y+   L  +A  F  S   + QEL   I+ G+L  KID  N ++       +N  +Q
Sbjct:   35 DSDLLGKMKKANEDELKRLDDVLEDAEKNLGESEIRDAMMAKAEYLIRIGDKEGALTAFRKTYDKTVALGHRLDIVFYLLRIGLFYMDNDLITRNTEKAKSLIEE-------------------GGDW------------DRRNRLKVYQGLYCVAI------RDFKQAAELFLDTVSTFTSYELMDYKTFVTYTVYVCMIA-LKRPDLREKVIKGAEILEVLHSLPDVRQYLFSLYECRYSIFFQSLARVEQDMKRDWLFAPHYRYYVREMRILAYSQLLESYRSLTLGYMAEAFGVSTEFIDQELSRFIAAGRLHCKIDKVNEIVETNRPDSKNWQYQ 336

[Close]

BLAST of COP9 signalosome complex subunit 1 vs. Ensembl Sea Lamprey
Match: psmd6 (proteasome 26S subunit, non-ATPase 6 [Source:ZFIN;Acc:ZDB-GENE-040426-1038])

HSP 1 Score: 78.9518 bits (193), Expect = 4.409e-16
Identity = 73/340 (21.47%), Postives = 137/340 (40.29%), Query Frame = 1

Query:  466 DSDWVDKTRRQSNQTIDQLDTDLKNYKANNMAESIRRGCDELASVHMKTGDLLSANKNYTRSRDYCKTDMHELMMCFNVIKVSIYLTHWRHVSSYVDRAETLLENITNGCSSTGSQNRSISDEVSGSWKQSSNTEKVTSDQKDNRQKMKALLHCVVGLVEMYERNFXXXXXXFLQADHDYVSFNSILTANDVALYGTICSLATFDRNALKSMVIQNSNFKMFLENEPTLRDILHNFYNFQYAECLKGMAQIKNQLLLDIYLADHVEYLYREIRNRALCQYFSPYQCADLNKIATCFNTSVPELLQELKPLISTGQLKAKIDSHNNLLLVTSISQQNQVFQ 1485
            D+  + + R  +   + +LD  L++ + N     IR      A    + GD  S+   + ++ +      H L + F +I++ ++      ++  +D+A++L+E                     G W              D R ++K       G+  +  R+F  AA  FL     + S+  ++       +    S+   +R  L+  VI+ +     L   P +R  L + Y   YA   + +A+++ ++  D   A H +Y  RE+R  A  Q    Y+   L+ +A  F  SV  + QEL   I+ G+L  KID  N ++       +N  +Q
Sbjct:   66 DAPLLARMRAANEAELARLDAALEDAERNLGESEIRDAMLARAEHLSRIGDKESSLTAFRKTFEKTVALGHRLDIVFYLIRIGLFYLDNDLITRNIDKAKSLIEE-------------------GGDW--------------DRRNRLK----VYQGVYLLAIRDFKGAAELFLDTVSTFTSYE-LMDYRTFVTHTVYVSMIALERPDLREKVIKGAEILEVLHGLPAVRQYLFSLYECHYASFFQSLAKVEQEMKADRLFAPHYQYYVREMRILAYSQLLESYRSLTLSYMAQAFGVSVEFVDQELSRFIAAGRLHCKIDKVNEIVETNRPDSKNWQYQ 367

[Close]

BLAST of COP9 signalosome complex subunit 1 vs. Ensembl Nematostella
Match: EDO36846 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7SHI2])

HSP 1 Score: 330.487 bits (846), Expect = 9.019e-108
Identity = 192/524 (36.64%), Postives = 288/524 (54.96%), Query Frame = 1

Query:   49 IEHMQLDLIEEDETISLLNDSPLQEVTE-------TTLDLDTYINNYKDFGKYLRLIFIARRCRPLRLEALVIALDWLKQSWNFVEYCKVFNIIATVVRDSIEMADATLTTLIPGVCCRDDFNFQRFQTRVSYETIRLPDGRFLEFDSDWVDKTRRQSNQTIDQLDTDLKNYKANNMAESIRRGCDELASVHMKTGDLLSANKNYTRSRDYCKTDMHELMMCFNVIKVSIYLTHWRHVSSYVDRAETLLENITNGCSSTGSQNRSISDEVSGSWKQSSNTEKVTSDQKDNRQKMKALLHCVVGLVEMYERNFXXXXXXFLQADHDYVSFNSILTANDVALYGTICSLATFDRNALKSMVIQNSNFKMFLENEPTLRDILHNFYNFQYAECLKGMAQIKNQLLLDIYLADHVEYLYREIRNRALCQYFSPYQCADLNKIATCFNTSVPELLQELKPLISTGQLKAKIDSHNNLLLVTSISQQNQVFQRAFHLFNSYEKRFKATFVHNACIRSELYQNVNTAQNYG 1599
            IE MQ+DL  E +          Q+ TE        TLDLD Y +NY    K  RL+F+A+ C  L +++L IA+ ++KQ++N   Y         +++  IE             C R                    D      ++ WV+ T +++   +++LDTDLKNYK+N++ ESIRRG D+L   + + GDL +A K Y+RSRDYC +  H + MC NVIKVSI++ +W HV +YV++AE                                NT ++T  ++ + Q     L C  GL E+  R + +AAR FLQA  D+     +L++N+VA+YG +C+LA+FDR  L+  V+ +S+FK+FLE EP LRD+L+ F+  QYA CLK +  +K+  +LD+YLA H+  LY +IR RAL QYFSPY  AD++K+A  FNT+V +L  EL  LI  GQ+ A+IDSHN +L    + Q++  F++A  +   Y+KR KA  +  A +R+++     T  + G
Sbjct:   14 IEPMQVDLAPESD----------QQATEEEFIVEGATLDLDVYASNYTGLTKLNRLLFVAKHCPSLEIDSLRIAIIFVKQTFNVQLY-------QDIIQKLIE------------ACSRQS------------------DMETPSVETTWVETTSKKAALKLEKLDTDLKNYKSNSIKESIRRGHDDLGDHYFECGDLNNALKCYSRSRDYCTSAKHVVNMCLNVIKVSIHMGNWSHVLNYVNKAE--------------------------------NTTELTEKERGSSQTTLTKLKCAAGLAELATRKYKSAARYFLQASFDHCDCPELLSSNNVAIYGGLCALASFDRQELQKKVLSSSSFKLFLELEPQLRDVLYKFHESQYATCLKLLDDLKDNFMLDMYLAQHITKLYSQIRKRALIQYFSPYVSADMSKMAHAFNTTVHQLEDELSQLILDGQINARIDSHNKVLYARDVDQRSTTFEKALEMGKEYQKRTKALILRAAILRNQIIVKSPTRDSTG 458

[Close]

BLAST of COP9 signalosome complex subunit 1 vs. Ensembl Nematostella
Match: EDO30816 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7SZN8])

HSP 1 Score: 74.3294 bits (181), Expect = 2.871e-14
Identity = 72/340 (21.18%), Postives = 135/340 (39.71%), Query Frame = 1

Query:  466 DSDWVDKTRRQSNQTIDQLDTDLKNYKANNMAESIRRGCDELASVHMKTGDLLSANKNYTRSRDYCKTDMHELMMCFNVIKVSIYLTHWRHVSSYVDRAETLLENITNGCSSTGSQNRSISDEVSGSWKQSSNTEKVTSDQKDNRQKMKALLHCVVGLVEMYERNFXXXXXXFLQADHDYVSFNSILTANDVALYGTICSLATFDRNALKSMVIQNSNFKMFLENEPTLRDILHNFYNFQYAECLKGMAQIKNQLLLDIYLADHVEYLYREIRNRALCQYFSPYQCADLNKIATCFNTSVPELLQELKPLISTGQLKAKIDSHNNLLLVTSISQQNQVFQ 1485
            D   ++K ++++ + +++LD  LK+ + N     IR             GD   A   + +S D      ++L + F  I++ ++      ++  + +A+ L+E                     G W              D R ++K       G+  M  R+F AAA  FL++   + S+  ++          + S+ + +R  L+  VI  +     L   P ++  L + Y   Y+E    +AQ++  L  D  ++ H  Y  RE+R  A  Q    Y+   L  +A  F  S   + +EL   I+ G+L  KID    ++       +N  +Q
Sbjct:   66 DKPLLEKMKQKNTEKLEELDKTLKDAEENLGETEIRDALFARGEYLCSIGDKEGAITAFRKSYDKAVALGYKLDILFYRIRIGLFYLDNDMITKNISKAKELIEE-------------------GGDW--------------DRRNRLK----VYQGIYFMSIRDFKAAASNFLESISTFTSY-ELMDYQTFVTNTILTSMISLERVDLRKKVINGAEILEVLHQLPVIKQFLVSLYECHYSEFFTALAQVEQMLKQDRLMSPHYRYYVREMRILAYTQLLESYRSLTLQYMANAFGVSEEFIDKELSRFIAAGRLNCKIDKVGGIVETNRPDHKNWQYQ 367

[Close]

BLAST of COP9 signalosome complex subunit 1 vs. Ensembl Medaka
Match: gps1 (G protein pathway suppressor 1 [Source:NCBI gene;Acc:101160817])

HSP 1 Score: 319.701 bits (818), Expect = 5.924e-103
Identity = 190/523 (36.33%), Postives = 289/523 (55.26%), Query Frame = 1

Query:   28 IFCKMSMIEHMQLDL-IEEDETISLLNDSPLQEVTE-TTLDLDTYINNYKDFGKYLRLIFIARRCRPLRLEALVIALDWLKQSWNFVEYCKVFNIIATVVRDSIEMADATLTTLIPGVCCRDDFNFQRFQTRVSYETIRLPDGRFLE--FDSDWVDKTRRQSNQTIDQLDTDLKNYKANNMAESIRRGCDELASVHMKTGDLLSANKNYTRSRDYCKTDMHELMMCFNVIKVSIYLTHWRHVSSYVDRAETLLENITNGCSSTGSQNRSISDEVSGSWKQSSNTEKVTSDQKDNRQKMKALLHCVVGLVEMYERNFXXXXXXFLQADHDYVS-----FNSILTANDVALYGTICSLATFDRNALKSMVIQNSNFKMFLENEPTLRDILHNFYNFQYAECLKGMAQIKNQLLLDIYLADHVEYLYREIRNRALCQYFSPYQCADLNKIATCFNTSVPELLQELKPLISTGQLKAKIDSHNNLLLVTSISQQNQVFQRAFHLFNSYEKRFKATFVHNACIRSELY 1569
            +F     +E MQ+D   +ED+     N   +  + E  TLDL+ +  +Y    +  RL FIA  C  LR+EAL +AL ++++++N   Y ++   +    RD  ++ D                               +PDG       DS W + TR+++   +++LDTDLKNYK N++ ESIRRG D+L   ++  GDL +A K Y+R+RDYC +  H + MC NVIKVS+YL +W HV SYV++AE+  E I         QN+++  +                            L C  GL E+  R +  AA+ FLQA  D+       F  +L+ ++VA+YG +C+LATFDR  L+  VI +S+FK+FLE EP +RDI+  FY  +YA CLK +  +K+ LLLD+YLA H++ LY +IRNRAL QYFSPY  AD+ K+A  FNT+V  L  EL  LI  G + A+IDSH+ +L    + Q++  F+++ H+   +++R KA  +  A +R++++
Sbjct:    7 VFNFQGSVEPMQIDADPQEDQQ----NAQDINYIVENPTLDLEQHATSYSGLMRIERLQFIAEHCPQLRVEALKMALTFVQRTFNVDAYEEIHRKLTEATRDLQDVPDT------------------------------VPDGGAAPPPLDSAWAESTRKKALLKLEKLDTDLKNYKGNSIKESIRRGHDDLGDHYLDCGDLSNALKCYSRARDYCTSAKHVINMCLNVIKVSVYLQNWSHVLSYVNKAESTPE-IAEQRGERDGQNQAVLTK----------------------------LKCAAGLAELASRKYKPAAKCFLQASFDHCDCPEFVFLQLLSPSNVAVYGGLCALATFDRQELQRNVISSSSFKLFLELEPQIRDIIFKFYESKYASCLKLLDDMKDNLLLDMYLAPHIKILYSQIRNRALIQYFSPYVSADMTKMAQAFNTTVAALEDELTQLILEGLVNARIDSHSKILYARDVDQRSTTFEKSLHMGKEFQRRAKAMILRAAVLRNQIH 466

[Close]

BLAST of COP9 signalosome complex subunit 1 vs. Ensembl Medaka
Match: psmd6 (proteasome 26S subunit, non-ATPase 6 [Source:NCBI gene;Acc:101172070])

HSP 1 Score: 82.4185 bits (202), Expect = 1.709e-16
Identity = 74/342 (21.64%), Postives = 143/342 (41.81%), Query Frame = 1

Query:  460 EFDSDWVDKTRRQSNQTIDQLDTDLKNYKANNMAESIRRGCDELASVHMKTGDLLSANKNYTRSRDYCKTDMHELMMCFNVIKVSIYLTHWRHVSSYVDRAETLLENITNGCSSTGSQNRSISDEVSGSWKQSSNTEKVTSDQKDNRQKMKALLHCVVGLVEMYERNFXXXXXXFLQADHDYVSFNSILTANDVALYGTICSLATFDRNALKSMVIQNSNFKMFLENEPTLRDILHNFYNFQYAECLKGMAQIKNQLLLDIYLADHVEYLYREIRNRALCQYFSPYQCADLNKIATCFNTSVPELLQELKPLISTGQLKAKIDSHNNLLLVTSISQQNQVFQ 1485
            + D++ + K ++ +++ + +LD  L++ + N     IR      A   ++ GD   A   + ++ D      H L + F ++++ ++      ++   ++A++L+E                     G W             + NR K+   L+CV        R+F  AA  FL     + S+  +     V     +C +A  +R  L+  VI+ +     L + P++R  L + Y  +Y+   + +A ++ ++  D   A H  Y  RE+R +A  Q    Y+   L  +A  F  S   + QEL   I+ G+L  KID  N ++       +N  +Q
Sbjct:   64 QLDTELLSKMKKANDEELKRLDDVLEDAEKNLGESEIRDVMMAKAEYLIRIGDKEGALTAFRKTYDKTVALGHRLDIVFYLLRIGLFYMDSDLITRNSEKAKSLIEE-------------------GGDW------------DRRNRLKVYQGLYCVAI------RDFKQAAELFLDTVSTFTSYELMDYKTFVTYTVYVCMIA-LERPDLREKVIKGAEILEVLHSLPSVRQYLFSLYECRYSAFFQSLAMVEQEMKKDWLFAPHYRYYVREMRIQAYSQLLESYRSLTLGYMAEAFGVSTEFIDQELSRFIAAGRLHCKIDKVNEIVETNRPDSKNWQYQ 367

[Close]

BLAST of COP9 signalosome complex subunit 1 vs. Planmine SMEST
Match: SMESG000027211.1 (SMESG000027211.1)

HSP 1 Score: 1082.78 bits (2799), Expect = 0.000e+0
Identity = 525/525 (100.00%), Postives = 525/525 (100.00%), Query Frame = 1

Query:   40 MSMIEHMQLDLIEEDETISLLNDSPLQEVTETTLDLDTYINNYKDFGKYLRLIFIARRCRPLRLEALVIALDWLKQSWNFVEYCKVFNIIATVVRDSIEMADATLTTLIPGVCCRDDFNFQRFQTRVSYETIRLPDGRFLEFDSDWVDKTRRQSNQTIDQLDTDLKNYKANNMAESIRRGCDELASVHMKTGDLLSANKNYTRSRDYCKTDMHELMMCFNVIKVSIYLTHWRHVSSYVDRAETLLENITNGCSSTGSQNRSISDEVSGSWKQSSNTEKVTSDQKDNRQKMKALLHCVVGLVEMYERNFXXXXXXFLQADHDYVSFNSILTANDVALYGTICSLATFDRNALKSMVIQNSNFKMFLENEPTLRDILHNFYNFQYAECLKGMAQIKNQLLLDIYLADHVEYLYREIRNRALCQYFSPYQCADLNKIATCFNTSVPELLQELKPLISTGQLKAKIDSHNNLLLVTSISQQNQVFQRAFHLFNSYEKRFKATFVHNACIRSELYQNVNTAQNYGDVQMD 1614
            MSMIEHMQLDLIEEDETISLLNDSPLQEVTETTLDLDTYINNYKDFGKYLRLIFIARRCRPLRLEALVIALDWLKQSWNFVEYCKVFNIIATVVRDSIEMADATLTTLIPGVCCRDDFNFQRFQTRVSYETIRLPDGRFLEFDSDWVDKTRRQSNQTIDQLDTDLKNYKANNMAESIRRGCDELASVHMKTGDLLSANKNYTRSRDYCKTDMHELMMCFNVIKVSIYLTHWRHVSSYVDRAETLLENITNGCSSTGSQNRSISDEVSGSWKQSSNTEKVTSDQKDNRQKMKALLHCVVGLVEMYERNFAAAARAFLQADHDYVSFNSILTANDVALYGTICSLATFDRNALKSMVIQNSNFKMFLENEPTLRDILHNFYNFQYAECLKGMAQIKNQLLLDIYLADHVEYLYREIRNRALCQYFSPYQCADLNKIATCFNTSVPELLQELKPLISTGQLKAKIDSHNNLLLVTSISQQNQVFQRAFHLFNSYEKRFKATFVHNACIRSELYQNVNTAQNYGDVQMD
Sbjct:    1 MSMIEHMQLDLIEEDETISLLNDSPLQEVTETTLDLDTYINNYKDFGKYLRLIFIARRCRPLRLEALVIALDWLKQSWNFVEYCKVFNIIATVVRDSIEMADATLTTLIPGVCCRDDFNFQRFQTRVSYETIRLPDGRFLEFDSDWVDKTRRQSNQTIDQLDTDLKNYKANNMAESIRRGCDELASVHMKTGDLLSANKNYTRSRDYCKTDMHELMMCFNVIKVSIYLTHWRHVSSYVDRAETLLENITNGCSSTGSQNRSISDEVSGSWKQSSNTEKVTSDQKDNRQKMKALLHCVVGLVEMYERNFAAAARAFLQADHDYVSFNSILTANDVALYGTICSLATFDRNALKSMVIQNSNFKMFLENEPTLRDILHNFYNFQYAECLKGMAQIKNQLLLDIYLADHVEYLYREIRNRALCQYFSPYQCADLNKIATCFNTSVPELLQELKPLISTGQLKAKIDSHNNLLLVTSISQQNQVFQRAFHLFNSYEKRFKATFVHNACIRSELYQNVNTAQNYGDVQMD 525

[Close]

BLAST of COP9 signalosome complex subunit 1 vs. Planmine SMEST
Match: SMESG000027211.1 (SMESG000027211.1)

HSP 1 Score: 1068.91 bits (2763), Expect = 0.000e+0
Identity = 519/519 (100.00%), Postives = 519/519 (100.00%), Query Frame = 1

Query:   58 MQLDLIEEDETISLLNDSPLQEVTETTLDLDTYINNYKDFGKYLRLIFIARRCRPLRLEALVIALDWLKQSWNFVEYCKVFNIIATVVRDSIEMADATLTTLIPGVCCRDDFNFQRFQTRVSYETIRLPDGRFLEFDSDWVDKTRRQSNQTIDQLDTDLKNYKANNMAESIRRGCDELASVHMKTGDLLSANKNYTRSRDYCKTDMHELMMCFNVIKVSIYLTHWRHVSSYVDRAETLLENITNGCSSTGSQNRSISDEVSGSWKQSSNTEKVTSDQKDNRQKMKALLHCVVGLVEMYERNFXXXXXXFLQADHDYVSFNSILTANDVALYGTICSLATFDRNALKSMVIQNSNFKMFLENEPTLRDILHNFYNFQYAECLKGMAQIKNQLLLDIYLADHVEYLYREIRNRALCQYFSPYQCADLNKIATCFNTSVPELLQELKPLISTGQLKAKIDSHNNLLLVTSISQQNQVFQRAFHLFNSYEKRFKATFVHNACIRSELYQNVNTAQNYGDVQMD 1614
            MQLDLIEEDETISLLNDSPLQEVTETTLDLDTYINNYKDFGKYLRLIFIARRCRPLRLEALVIALDWLKQSWNFVEYCKVFNIIATVVRDSIEMADATLTTLIPGVCCRDDFNFQRFQTRVSYETIRLPDGRFLEFDSDWVDKTRRQSNQTIDQLDTDLKNYKANNMAESIRRGCDELASVHMKTGDLLSANKNYTRSRDYCKTDMHELMMCFNVIKVSIYLTHWRHVSSYVDRAETLLENITNGCSSTGSQNRSISDEVSGSWKQSSNTEKVTSDQKDNRQKMKALLHCVVGLVEMYERNFAAAARAFLQADHDYVSFNSILTANDVALYGTICSLATFDRNALKSMVIQNSNFKMFLENEPTLRDILHNFYNFQYAECLKGMAQIKNQLLLDIYLADHVEYLYREIRNRALCQYFSPYQCADLNKIATCFNTSVPELLQELKPLISTGQLKAKIDSHNNLLLVTSISQQNQVFQRAFHLFNSYEKRFKATFVHNACIRSELYQNVNTAQNYGDVQMD
Sbjct:    1 MQLDLIEEDETISLLNDSPLQEVTETTLDLDTYINNYKDFGKYLRLIFIARRCRPLRLEALVIALDWLKQSWNFVEYCKVFNIIATVVRDSIEMADATLTTLIPGVCCRDDFNFQRFQTRVSYETIRLPDGRFLEFDSDWVDKTRRQSNQTIDQLDTDLKNYKANNMAESIRRGCDELASVHMKTGDLLSANKNYTRSRDYCKTDMHELMMCFNVIKVSIYLTHWRHVSSYVDRAETLLENITNGCSSTGSQNRSISDEVSGSWKQSSNTEKVTSDQKDNRQKMKALLHCVVGLVEMYERNFAAAARAFLQADHDYVSFNSILTANDVALYGTICSLATFDRNALKSMVIQNSNFKMFLENEPTLRDILHNFYNFQYAECLKGMAQIKNQLLLDIYLADHVEYLYREIRNRALCQYFSPYQCADLNKIATCFNTSVPELLQELKPLISTGQLKAKIDSHNNLLLVTSISQQNQVFQRAFHLFNSYEKRFKATFVHNACIRSELYQNVNTAQNYGDVQMD 519

[Close]

BLAST of COP9 signalosome complex subunit 1 vs. Planmine SMEST
Match: SMESG000066079.1 (SMESG000066079.1)

HSP 1 Score: 87.0409 bits (214), Expect = 3.965e-18
Identity = 74/343 (21.57%), Postives = 143/343 (41.69%), Query Frame = 1

Query:  457 LEFDSDWVDKTRRQSNQTIDQLDTDLKNYKANNMAESIRRGCDELASVHMKTGDLLSANKNYTRSRDYCKTDMHELMMCFNVIKVSIYLTHWRHVSSYVDRAETLLENITNGCSSTGSQNRSISDEVSGSWKQSSNTEKVTSDQKDNRQKMKALLHCVVGLVEMYERNFXXXXXXFLQADHDYVSFNSILTANDVALYGTICSLATFDRNALKSMVIQNSNFKMFLENEPTLRDILHNFYNFQYAECLKGMAQIKNQLLLDIYLADHVEYLYREIRNRALCQYFSPYQCADLNKIATCFNTSVPELLQELKPLISTGQLKAKIDSHNNLLLVTSISQQNQVFQ 1485
            +  D+  ++K +  +   + +LD ++KN + N+    +R      A    K G    A   +    +      + L + F++I++  +    + ++  +++A  L+E                     G W              D R ++K       GL  +  R F  AA  FL+A   + S+  ++      +Y  + S+ +  R+ L+  V++ S     L + P++++ L + Y  +Y++  + +A I+N + +D YL  H  Y  RE+R  A  Q+   Y    +  ++  F  S+  L  EL   IS G+L  KID  N ++  T     N  +Q
Sbjct:   62 IPMDNSLLEKMKSANEDKLKELDNNIKNAEENHGDTEVREAMIAKAHYLSKIGAREKALDQFNLILEKTLMLGYRLDLTFHLIRIGFFFNDRKLITKNIEKANNLIEE-------------------GGDW--------------DRRNRLK----VYKGLYSLSIREFENAANHFLEAVATFTSY-ELMDYKTFIIYTVLASMISLKRSDLRDKVVRGSEILEVLHSLPSVKEFLMSLYECRYSDFFRYLAGIENYMKIDSYLCPHYRYYIREMRILAYKQHLESYNSLSVINMSKLFGISIEFLDNELSRFISNGRLACKIDQVNGIIETTRPDSVNSQYQ 366

[Close]

BLAST of COP9 signalosome complex subunit 1 vs. Planmine SMEST
Match: SMESG000066093.1 (SMESG000066093.1)

HSP 1 Score: 87.0409 bits (214), Expect = 3.975e-18
Identity = 74/343 (21.57%), Postives = 143/343 (41.69%), Query Frame = 1

Query:  457 LEFDSDWVDKTRRQSNQTIDQLDTDLKNYKANNMAESIRRGCDELASVHMKTGDLLSANKNYTRSRDYCKTDMHELMMCFNVIKVSIYLTHWRHVSSYVDRAETLLENITNGCSSTGSQNRSISDEVSGSWKQSSNTEKVTSDQKDNRQKMKALLHCVVGLVEMYERNFXXXXXXFLQADHDYVSFNSILTANDVALYGTICSLATFDRNALKSMVIQNSNFKMFLENEPTLRDILHNFYNFQYAECLKGMAQIKNQLLLDIYLADHVEYLYREIRNRALCQYFSPYQCADLNKIATCFNTSVPELLQELKPLISTGQLKAKIDSHNNLLLVTSISQQNQVFQ 1485
            +  D+  ++K +  +   + +LD ++KN + N+    +R      A    K G    A   +    +      + L + F++I++  +    + ++  +++A  L+E                     G W              D R ++K       GL  +  R F  AA  FL+A   + S+  ++      +Y  + S+ +  R+ L+  V++ S     L + P++++ L + Y  +Y++  + +A I+N + +D YL  H  Y  RE+R  A  Q+   Y    +  ++  F  S+  L  EL   IS G+L  KID  N ++  T     N  +Q
Sbjct:   62 IPMDNSLLEKMKSTNEDKLKELDNNIKNAEENHGDTEVREAMIAKAHYLSKIGAREKALDQFNLILEKTLMLGYRLDLTFHLIRIGFFFNDRKLITKNIEKANNLIEE-------------------GGDW--------------DRRNRLK----VYKGLYSLSIREFENAANHFLEAVATFTSY-ELMDYKTFIIYTVLASMISLKRSDLRDKVVRGSEILEVLHSLPSVKEFLMSLYECRYSDFFRYLAGIENYMKIDSYLCPHYRYYIREMRILAYKQHLESYNSLSVINMSKLFGISIEFLDNELSRFISNGRLACKIDQVNGIIETTRPDSVNSQYQ 366

The following BLAST results are available for this feature:

BLAST of COP9 signalosome complex subunit 1 vs. Ensembl Human
BLAST of COP9 signalosome complex subunit 1 vs. Ensembl Celegans
BLAST of COP9 signalosome complex subunit 1 vs. Ensembl Fly
BLAST of COP9 signalosome complex subunit 1 vs. Ensembl Zebrafish
BLAST of COP9 signalosome complex subunit 1 vs. Ensembl Xenopus
BLAST of COP9 signalosome complex subunit 1 vs. Ensembl Mouse
BLAST of COP9 signalosome complex subunit 1 vs. UniProt/SwissProt
BLAST of COP9 signalosome complex subunit 1 vs. TrEMBL
BLAST of COP9 signalosome complex subunit 1 vs. Ensembl Cavefish
BLAST of COP9 signalosome complex subunit 1 vs. Ensembl Sea Lamprey
BLAST of COP9 signalosome complex subunit 1 vs. Ensembl Yeast
BLAST of COP9 signalosome complex subunit 1 vs. Ensembl Nematostella
BLAST of COP9 signalosome complex subunit 1 vs. Ensembl Medaka
BLAST of COP9 signalosome complex subunit 1 vs. Planmine SMEST

BLAST of COP9 signalosome complex subunit 1 vs. Ensembl Human
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Human e!99)
Total hits: 5


Match Name	E-value	Identity	Description
GPS1	4.188e-103	35.34	G protein pathway suppressor 1 [Source:HGNC Symbol...	[more]
GPS1	1.726e-102	35.92	G protein pathway suppressor 1 [Source:HGNC Symbol...	[more]
GPS1	5.908e-102	35.73	G protein pathway suppressor 1 [Source:HGNC Symbol...	[more]
GPS1	2.015e-101	36.22	G protein pathway suppressor 1 [Source:HGNC Symbol...	[more]
GPS1	2.211e-101	36.31	G protein pathway suppressor 1 [Source:HGNC Symbol...	[more]

BLAST of COP9 signalosome complex subunit 1 vs. Ensembl Celegans
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99)
Total hits: 2


Match Name	E-value	Identity	Description
csn-1	3.835e-36	23.26	COP9 signalosome complex subunit 1 [Source:UniPro...	[more]
rpn-7	4.875e-18	22.19	26S proteasome non-ATPase regulatory subunit 6 [S...	[more]

BLAST of COP9 signalosome complex subunit 1 vs. Ensembl Fly
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99)
Total hits: 3


Match Name	E-value	Identity	Description
CSN1b	3.827e-95	41.19	gene:FBgn0027057 transcript:FBtr0075074	[more]
CSN1a	2.237e-44	29.23	gene:FBgn0028838 transcript:FBtr0080671	[more]
Rpn7	1.103e-17	21.47	gene:FBgn0028688 transcript:FBtr0084294	[more]

BLAST of COP9 signalosome complex subunit 1 vs. Ensembl Zebrafish
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99)
Total hits: 4


Match Name	E-value	Identity	Description
gps1	1.010e-105	36.43	G protein pathway suppressor 1 [Source:ZFIN;Acc:ZD...	[more]
gps1	5.076e-105	36.38	G protein pathway suppressor 1 [Source:ZFIN;Acc:ZD...	[more]
gps1	5.258e-101	35.01	G protein pathway suppressor 1 [Source:ZFIN;Acc:ZD...	[more]
psmd6	3.297e-16	22.35	proteasome 26S subunit, non-ATPase 6 [Source:ZFIN;...	[more]

BLAST of COP9 signalosome complex subunit 1 vs. Ensembl Xenopus
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99)
Total hits: 4


Match Name	E-value	Identity	Description
gps1	8.192e-105	37.38	G protein pathway suppressor 1 [Source:NCBI gene;A...	[more]
gps1	1.338e-90	34.88	G protein pathway suppressor 1 [Source:NCBI gene;A...	[more]
gps1	6.863e-90	34.83	G protein pathway suppressor 1 [Source:NCBI gene;A...	[more]
psmd9	2.003e-18	22.65	proteasome 26S subunit, non-ATPase 9 [Source:Xenba...	[more]

BLAST of COP9 signalosome complex subunit 1 vs. Ensembl Mouse
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99)
Total hits: 5


Match Name	E-value	Identity	Description
Gps1	6.410e-107	36.50	G protein pathway suppressor 1 [Source:MGI Symbol;...	[more]
Gps1	2.305e-106	36.73	G protein pathway suppressor 1 [Source:MGI Symbol;...	[more]
Gps1	8.072e-106	36.89	G protein pathway suppressor 1 [Source:MGI Symbol;...	[more]
Gps1	2.736e-105	37.01	G protein pathway suppressor 1 [Source:MGI Symbol;...	[more]
Psmd6	7.430e-17	21.64	proteasome (prosome, macropain) 26S subunit, non-A...	[more]

BLAST of COP9 signalosome complex subunit 1 vs. UniProt/SwissProt
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt)
Total hits: 5


Match Name	E-value	Identity	Description
sp\|Q6NRT5\|CSN1_XENLA	1.833e-106	37.40	COP9 signalosome complex subunit 1 OS=Xenopus laev...	[more]
sp\|Q99LD4\|CSN1_MOUSE	4.411e-104	37.97	COP9 signalosome complex subunit 1 OS=Mus musculus...	[more]
sp\|P97834\|CSN1_RAT	8.495e-104	37.76	COP9 signalosome complex subunit 1 OS=Rattus norve...	[more]
sp\|Q13098\|CSN1_HUMAN	2.837e-101	35.73	COP9 signalosome complex subunit 1 OS=Homo sapiens...	[more]
sp\|Q9VVU5\|CSN1_DROME	3.837e-94	41.19	COP9 signalosome complex subunit 1b OS=Drosophila ...	[more]

BLAST of COP9 signalosome complex subunit 1 vs. TrEMBL
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL)
Total hits: 5


Match Name	E-value	Identity	Description
R7UZX3	2.516e-113	39.16	PCI domain-containing protein OS=Capitella teleta ...	[more]
K1RS36	4.158e-112	38.37	COP9 signalosome complex subunit 1 OS=Crassostrea ...	[more]
V3Z109	7.875e-111	37.52	PCI domain-containing protein OS=Lottia gigantea O...	[more]
A0A210QT24	8.690e-111	38.58	COP9 signalosome complex subunit 1 OS=Mizuhopecten...	[more]
A0A2T7PZD5	3.011e-109	38.19	PCI domain-containing protein OS=Pomacea canalicul...	[more]

BLAST of COP9 signalosome complex subunit 1 vs. Ensembl Cavefish
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99)
Total hits: 5


Match Name	E-value	Identity	Description
gps1	4.306e-106	36.63	G protein pathway suppressor 1 [Source:NCBI gene;A...	[more]
gps1	1.478e-105	38.02	G protein pathway suppressor 1 [Source:NCBI gene;A...	[more]
gps1	3.587e-105	38.02	G protein pathway suppressor 1 [Source:NCBI gene;A...	[more]
gps1	6.210e-97	40.00	G protein pathway suppressor 1 [Source:NCBI gene;A...	[more]
psmd6	4.612e-16	22.35	proteasome 26S subunit, non-ATPase 6 [Source:ZFIN;...	[more]

BLAST of COP9 signalosome complex subunit 1 vs. Ensembl Sea Lamprey
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99)
Total hits: 1


Match Name	E-value	Identity	Description
psmd6	4.409e-16	21.47	proteasome 26S subunit, non-ATPase 6 [Source:ZFIN;...	[more]

BLAST of COP9 signalosome complex subunit 1 vs. Ensembl Yeast
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46)
Total hits: 0


Match Name	E-value	Identity	Description

BLAST of COP9 signalosome complex subunit 1 vs. Ensembl Nematostella
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46)
Total hits: 2


Match Name	E-value	Identity	Description
EDO36846	9.019e-108	36.64	Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7...	[more]
EDO30816	2.871e-14	21.18	Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7...	[more]

BLAST of COP9 signalosome complex subunit 1 vs. Ensembl Medaka
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99)
Total hits: 2


Match Name	E-value	Identity	Description
gps1	5.924e-103	36.33	G protein pathway suppressor 1 [Source:NCBI gene;A...	[more]
psmd6	1.709e-16	21.64	proteasome 26S subunit, non-ATPase 6 [Source:NCBI ...	[more]

BLAST of COP9 signalosome complex subunit 1 vs. Planmine SMEST
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST)
Total hits: 4


Match Name	E-value	Identity	Description
SMESG000027211.1	0.000e+0	100.00	SMESG000027211.1	[more]
SMESG000027211.1	0.000e+0	100.00	SMESG000027211.1	[more]
SMESG000066079.1	3.965e-18	21.57	SMESG000066079.1	[more]
SMESG000066093.1	3.975e-18	21.57	SMESG000066093.1	[more]

Analyses

This transcript is derived from or has results from the following analyses


Analysis Name	Date Performed
Embryonic Stages	2016-07-25
Schmidtea mediterranea smed_20140614 BLASTX Human e!99	2016-08-08
Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99	2016-08-08
Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL	2020-05-01
Schmidtea mediterranea Sexual smed_20140614 transcriptome	2016-07-25
Schmidtea mediteranean smed_20140614 Interproscan	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST	2020-05-08

Sequences

The following sequences are available for this feature:

transcript sequence
protein sequence

transcript sequence

>SMED30010138 ID=SMED30010138|Name=COP9 signalosome complex subunit 1|organism=Schmidtea mediterranea sexual|type=transcript|length=1672bp
CAAAAATTATAAATCGCATATTTTACAATTTTTTGTAAAATGTCAATGAT
TGAACATATGCAATTAGATTTGATTGAAGAAGATGAAACTATTAGTTTAT
TAAATGATAGTCCACTTCAAGAGGTTACCGAAACTACTTTGGATTTAGAT
ACATATATTAATAATTATAAGGACTTTGGAAAATATCTACGGCTCATTTT
TATCGCTAGACGGTGTAGACCATTGCGCCTTGAAGCTTTGGTAATTGCAT
TGGATTGGCTTAAACAGTCATGGAATTTTGTGGAGTATTGTAAAGTTTTC
AATATAATCGCTACAGTTGTTCGAGATTCAATTGAAATGGCTGATGCTAC
ATTGACAACTTTAATTCCAGGCGTTTGCTGTAGAGATGATTTTAATTTTC
AAAGATTTCAAACCAGAGTTTCTTATGAAACTATTAGATTACCTGATGGC
AGGTTTTTGGAATTTGATTCTGATTGGGTAGACAAGACACGTCGTCAGTC
TAACCAGACGATAGACCAATTGGATACTGATTTGAAAAATTACAAAGCGA
ATAACATGGCCGAAAGTATTCGTCGAGGTTGTGATGAATTGGCATCAGTT
CATATGAAGACTGGGGATTTGTTAAGTGCCAATAAGAATTACACAAGGTC
GAGGGATTACTGCAAAACCGATATGCACGAGTTGATGATGTGCTTCAATG
TAATCAAGGTGTCGATATATCTGACACATTGGCGTCATGTTTCATCGTAT
GTGGATCGGGCAGAAACGCTGCTGGAAAACATTACAAACGGTTGCAGTTC
CACTGGTTCCCAAAACCGTTCCATAAGTGACGAAGTATCAGGCTCATGGA
AACAATCAAGCAACACAGAAAAAGTGACATCTGACCAAAAGGATAACCGG
CAAAAGATGAAAGCATTGCTCCACTGCGTTGTTGGTCTTGTGGAAATGTA
TGAAAGGAATTTCGCCGCTGCCGCTAGAGCTTTCCTTCAGGCCGATCACG
ACTACGTCTCATTCAACAGCATTCTCACCGCCAATGATGTCGCTCTCTAT
GGAACAATTTGCTCCCTGGCAACGTTTGATAGGAACGCCCTTAAGAGCAT
GGTCATACAGAATTCGAACTTCAAAATGTTTCTCGAGAACGAGCCAACAC
TGCGAGATATTCTTCATAATTTCTACAATTTCCAGTACGCAGAATGTCTT
AAGGGAATGGCACAAATCAAGAATCAGTTGCTACTGGATATCTATCTCGC
TGATCACGTCGAGTACCTTTATAGGGAGATCAGGAACCGTGCATTGTGTC
AGTATTTTAGTCCATATCAATGTGCCGATCTGAACAAGATTGCCACATGC
TTCAACACTTCTGTCCCCGAACTACTCCAGGAATTGAAACCCTTGATCAG
CACCGGCCAATTGAAAGCAAAAATCGATTCTCACAATAATCTATTGCTCG
TCACAAGCATCAGTCAACAGAATCAAGTATTTCAAAGAGCATTTCATCTG
TTCAATAGCTATGAAAAACGATTCAAGGCAACTTTTGTCCATAACGCATG
CATTCGATCGGAATTGTATCAAAATGTGAATACCGCCCAGAATTATGGAG
ATGTACAGATGGATTACCAGTAAATTTACTTATTGCTTTTTTTGTTCCAA
TAAATACGTTCTTTGAAAAAAA

protein sequence of SMED30010138-orf-1

>SMED30010138-orf-1 ID=SMED30010138-orf-1|Name=SMED30010138-orf-1|organism=Schmidtea mediterranea sexual|type=polypeptide|length=528bp
MSMIEHMQLDLIEEDETISLLNDSPLQEVTETTLDLDTYINNYKDFGKYL
RLIFIARRCRPLRLEALVIALDWLKQSWNFVEYCKVFNIIATVVRDSIEM
ADATLTTLIPGVCCRDDFNFQRFQTRVSYETIRLPDGRFLEFDSDWVDKT
RRQSNQTIDQLDTDLKNYKANNMAESIRRGCDELASVHMKTGDLLSANKN
YTRSRDYCKTDMHELMMCFNVIKVSIYLTHWRHVSSYVDRAETLLENITN
GCSSTGSQNRSISDEVSGSWKQSSNTEKVTSDQKDNRQKMKALLHCVVGL
VEMYERNFAAAARAFLQADHDYVSFNSILTANDVALYGTICSLATFDRNA
LKSMVIQNSNFKMFLENEPTLRDILHNFYNFQYAECLKGMAQIKNQLLLD
IYLADHVEYLYREIRNRALCQYFSPYQCADLNKIATCFNTSVPELLQELK
PLISTGQLKAKIDSHNNLLLVTSISQQNQVFQRAFHLFNSYEKRFKATFV
HNACIRSELYQNVNTAQNYGDVQMDYQ*

Annotated Terms

The following terms have been associated with this transcript:

Vocabulary: **Planarian Anatomy**
Term	Definition
PLANA:0000101	muscle cell
PLANA:0000142	posterior region of the whole animal

Vocabulary: **INTERPRO**
Term	Definition
IPR033008	CSN1
IPR036390	WH_DNA-bd_sf
IPR000717	PCI_dom
IPR019585	Rpn7/CSN1
IPR011991	WHTH_DNA-bd_dom

Vocabulary: **molecular function**
Term	Definition
GO:0005515	protein binding

Vocabulary: **biological process**
Term	Definition
GO:0000338	protein deneddylation

Vocabulary: **cellular component**
Term	Definition
GO:0008180	COP9 signalosome

InterPro

Analysis Name: Schmidtea mediteranean smed_20140614 Interproscan
Date Performed: 2020-05-01


IPR Term	IPR Description	Source	Source Term	Source Description	Alignment
None	No IPR available	COILS	Coil	Coil	coord: 151..171
None	No IPR available	SMART	SM00753	PINT	coord: 405..488 e-value: 5.8E-10 score: 49.1
None	No IPR available	GENE3D	G3DSA:1.25.40.570		coord: 263..425 e-value: 1.1E-51 score: 177.9
None	No IPR available	MOBIDB_LITE	mobidb-lite	disorder_prediction	coord: 256..277
None	No IPR available	MOBIDB_LITE	mobidb-lite	disorder_prediction	coord: 256..284
None	No IPR available	PANTHER	PTHR14145	26S PROTESOME SUBUNIT 6	coord: 22..514
IPR000717	Proteasome component (PCI) domain	SMART	SM00088	PINT_4	coord: 405..488 e-value: 5.8E-10 score: 49.1
IPR000717	Proteasome component (PCI) domain	PFAM	PF01399	PCI	coord: 370..471 e-value: 6.4E-15 score: 55.6
IPR000717	Proteasome component (PCI) domain	PROSITE	PS50250	PCI	coord: 307..476 score: 17.229
IPR019585	26S proteasome regulatory subunit Rpn7/COP9 signalosome complex subunit 1	PFAM	PF10602	RPN7	coord: 143..353 e-value: 1.2E-43 score: 148.8
IPR033008	COP9 signalosome complex subunit 1	PANTHER	PTHR14145:SF2	COP9 SIGNALOSOME COMPLEX SUBUNIT 1	coord: 22..514
IPR036390	Winged helix DNA-binding domain superfamily	SUPERFAMILY	SSF46785	"Winged helix" DNA-binding domain	coord: 400..480

Main menu

COP9 signalosome complex subunit 1

Zeng et. al., 2018

▻ Overview

▻ Neoblast Population

▻ Sub-lethal Irradiated Surviving X1 and X2 Cell Population

Overview

Single cell RNA-seq of pluripotent neoblasts and its early progenies

Explore this single cell expression dataset with our NB Cluster Shiny App

Neoblast Population

Sub-lethal Irradiated Surviving X1 and X2 Cell Population

Davies et. al., 2017

PAGE et. al., 2020

has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGE

PAGE Curations: 2

Owlery

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