Receptor protein serine/threonine kinase
|
Overview
Neoblast Clusters
Zeng et. al., 2018▻ Overview▻ Neoblast Population▻ Sub-lethal Irradiated Surviving X1 and X2 Cell Population
Overview
Single cell RNA-seq of pluripotent neoblasts and its early progeniesWe isolated X1 neoblasts cells enriched in high piwi-1 expression (Neoblast Population), and profiled ∼7,614 individual cells via scRNA-seq. Unsupervised analyses uncovered 12 distinct classes from 7,088 high-quality cells. We designated these classes Nb1 to Nb12 and ordered them based on high (Nb1) to low (Nb12) piwi-1 expression levels. We further defined groups of genes that best classified the cells parsed into 12 distinct cell clusters to generate a scaled expression heat map of discriminative gene sets for each cluster. Expression of each cluster’s gene signatures was validated using multiplex fluorescence in situ hybridization (FISH) co-stained with piwi-1 and largely confirmed the cell clusters revealed by scRNA-seq.We also tested sub-lethal irradiation exposure. To profile rare pluripotent stem cells (PSCs) and avoid interference from immediate progenitor cells, we determined a time point after sub-lethal irradiation (7 DPI) with minimal piwi-1+ cells, followed by isolation and single-cell RNA-seq of 1,200 individual cells derived from X1 (Piwi-1 high) and X2 (Piwi-1 low) cell populations (Sub-lethal Irradiated Surviving X1 and X2 Cell Population)Explore this single cell expression dataset with our NB Cluster Shiny App
Neoblast Population
Sub-lethal Irradiated Surviving X1 and X2 Cell Population
Embryonic Expression
Davies et. al., 2017
Hover the mouse over a column in the graph to view average RPKM values per sample. Embryonic Stages: Y: yolk. S2-S8: Stages 2-8. C4: asexual adult. SX: virgin, sexually mature adult. back to top Anatomical Expression
PAGE et. al., 2020SMED30010098 has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGEPAGE Curations: 7
Homology
BLAST of Receptor protein serine/threonine kinase vs. Ensembl Human
Match: ACVR1 (activin A receptor type 1 [Source:HGNC Symbol;Acc:HGNC:171]) HSP 1 Score: 320.087 bits (819), Expect = 1.189e-100 Identity = 181/356 (50.84%), Postives = 230/356 (64.61%), Query Frame = 3
Query: 759 TLEKLRDDTCTSGSGSGLPFLVQRTVARQINLLECIGKGKFGEVWKGQFQGELVAVKIFXXXXXXXXXXXXNIYNTVLLRHDNILGYYASDLISNSGCTQLWMVMQYHPLGSLHEYLSANTLTVSTVLKLAHSAAAGLCHLHTRIMGLQGKPAIAHRDVKSKNILVKKNLTCCIADLGLAVFPESMGXXXXXXXXXXXRIVGTKRYMAPELLE----LACFLXXXXXXXXXXXXXXXXXXXXXXIMNIHGENYMESLKAADVYSYSLVLWEILSRTTFDGVIQPYQLPFGENVQSDPSFEEMFKVVVEQGLRPNLSEN--IKAQLNPVVKIMEECWHQRPSIRLSMLRVKKSLFNI 1808
TL L D +CTSGSGSGLPFLVQRTVARQI LLEC+GKG++GEVW+G +QGE VAVKIFSSR+E SW RET +YNTV+LRH+NILG+ ASD+ S TQLW++ YH +GSL++YL TL + L++ S A+GL HLH I G QGKPAIAHRD+KSKNILVKKN CCIADLGLAV + + NN VGTKRYMAPE+L+ + CF +S K D++++ LVLWE+ R +G+++ Y+ PF + V +DPSFE+M KVV RPN+ L + K+M+ECW+Q PS RL+ LR+KK+L I
Sbjct: 179 TLADLLDHSCTSGSGSGLPFLVQRTVARQITLLECVGKGRYGEVWRGSWQGENVAVKIFSSRDEKSWFRETELYNTVMLRHENILGFIASDMTSRHSSTQLWLITHYHEMGSLYDYLQLTTLDTVSCLRIVLSIASGLAHLHIEIFGTQGKPAIAHRDLKSKNILVKKNGQCCIADLGLAVM---HSQSTNQLDVGNNPRVGTKRYMAPEVLDETIQVDCF---------------------------------DSYKRVDIWAFGLVLWEVARRMVSNGIVEDYKPPFYDVVPNDPSFEDMRKVVCVDQQRPNIPNRWFSDPTLTSLAKLMKECWYQNPSARLTALRIKKTLTKI 498
BLAST of Receptor protein serine/threonine kinase vs. Ensembl Human
Match: ACVR1 (activin A receptor type 1 [Source:HGNC Symbol;Acc:HGNC:171]) HSP 1 Score: 320.087 bits (819), Expect = 1.189e-100 Identity = 181/356 (50.84%), Postives = 230/356 (64.61%), Query Frame = 3
Query: 759 TLEKLRDDTCTSGSGSGLPFLVQRTVARQINLLECIGKGKFGEVWKGQFQGELVAVKIFXXXXXXXXXXXXNIYNTVLLRHDNILGYYASDLISNSGCTQLWMVMQYHPLGSLHEYLSANTLTVSTVLKLAHSAAAGLCHLHTRIMGLQGKPAIAHRDVKSKNILVKKNLTCCIADLGLAVFPESMGXXXXXXXXXXXRIVGTKRYMAPELLE----LACFLXXXXXXXXXXXXXXXXXXXXXXIMNIHGENYMESLKAADVYSYSLVLWEILSRTTFDGVIQPYQLPFGENVQSDPSFEEMFKVVVEQGLRPNLSEN--IKAQLNPVVKIMEECWHQRPSIRLSMLRVKKSLFNI 1808
TL L D +CTSGSGSGLPFLVQRTVARQI LLEC+GKG++GEVW+G +QGE VAVKIFSSR+E SW RET +YNTV+LRH+NILG+ ASD+ S TQLW++ YH +GSL++YL TL + L++ S A+GL HLH I G QGKPAIAHRD+KSKNILVKKN CCIADLGLAV + + NN VGTKRYMAPE+L+ + CF +S K D++++ LVLWE+ R +G+++ Y+ PF + V +DPSFE+M KVV RPN+ L + K+M+ECW+Q PS RL+ LR+KK+L I
Sbjct: 179 TLADLLDHSCTSGSGSGLPFLVQRTVARQITLLECVGKGRYGEVWRGSWQGENVAVKIFSSRDEKSWFRETELYNTVMLRHENILGFIASDMTSRHSSTQLWLITHYHEMGSLYDYLQLTTLDTVSCLRIVLSIASGLAHLHIEIFGTQGKPAIAHRDLKSKNILVKKNGQCCIADLGLAVM---HSQSTNQLDVGNNPRVGTKRYMAPEVLDETIQVDCF---------------------------------DSYKRVDIWAFGLVLWEVARRMVSNGIVEDYKPPFYDVVPNDPSFEDMRKVVCVDQQRPNIPNRWFSDPTLTSLAKLMKECWYQNPSARLTALRIKKTLTKI 498
BLAST of Receptor protein serine/threonine kinase vs. Ensembl Human
Match: ACVR1 (activin A receptor type 1 [Source:HGNC Symbol;Acc:HGNC:171]) HSP 1 Score: 320.087 bits (819), Expect = 1.189e-100 Identity = 181/356 (50.84%), Postives = 230/356 (64.61%), Query Frame = 3
Query: 759 TLEKLRDDTCTSGSGSGLPFLVQRTVARQINLLECIGKGKFGEVWKGQFQGELVAVKIFXXXXXXXXXXXXNIYNTVLLRHDNILGYYASDLISNSGCTQLWMVMQYHPLGSLHEYLSANTLTVSTVLKLAHSAAAGLCHLHTRIMGLQGKPAIAHRDVKSKNILVKKNLTCCIADLGLAVFPESMGXXXXXXXXXXXRIVGTKRYMAPELLE----LACFLXXXXXXXXXXXXXXXXXXXXXXIMNIHGENYMESLKAADVYSYSLVLWEILSRTTFDGVIQPYQLPFGENVQSDPSFEEMFKVVVEQGLRPNLSEN--IKAQLNPVVKIMEECWHQRPSIRLSMLRVKKSLFNI 1808
TL L D +CTSGSGSGLPFLVQRTVARQI LLEC+GKG++GEVW+G +QGE VAVKIFSSR+E SW RET +YNTV+LRH+NILG+ ASD+ S TQLW++ YH +GSL++YL TL + L++ S A+GL HLH I G QGKPAIAHRD+KSKNILVKKN CCIADLGLAV + + NN VGTKRYMAPE+L+ + CF +S K D++++ LVLWE+ R +G+++ Y+ PF + V +DPSFE+M KVV RPN+ L + K+M+ECW+Q PS RL+ LR+KK+L I
Sbjct: 179 TLADLLDHSCTSGSGSGLPFLVQRTVARQITLLECVGKGRYGEVWRGSWQGENVAVKIFSSRDEKSWFRETELYNTVMLRHENILGFIASDMTSRHSSTQLWLITHYHEMGSLYDYLQLTTLDTVSCLRIVLSIASGLAHLHIEIFGTQGKPAIAHRDLKSKNILVKKNGQCCIADLGLAVM---HSQSTNQLDVGNNPRVGTKRYMAPEVLDETIQVDCF---------------------------------DSYKRVDIWAFGLVLWEVARRMVSNGIVEDYKPPFYDVVPNDPSFEDMRKVVCVDQQRPNIPNRWFSDPTLTSLAKLMKECWYQNPSARLTALRIKKTLTKI 498
BLAST of Receptor protein serine/threonine kinase vs. Ensembl Human
Match: ACVR1 (activin A receptor type 1 [Source:HGNC Symbol;Acc:HGNC:171]) HSP 1 Score: 320.087 bits (819), Expect = 1.189e-100 Identity = 181/356 (50.84%), Postives = 230/356 (64.61%), Query Frame = 3
Query: 759 TLEKLRDDTCTSGSGSGLPFLVQRTVARQINLLECIGKGKFGEVWKGQFQGELVAVKIFXXXXXXXXXXXXNIYNTVLLRHDNILGYYASDLISNSGCTQLWMVMQYHPLGSLHEYLSANTLTVSTVLKLAHSAAAGLCHLHTRIMGLQGKPAIAHRDVKSKNILVKKNLTCCIADLGLAVFPESMGXXXXXXXXXXXRIVGTKRYMAPELLE----LACFLXXXXXXXXXXXXXXXXXXXXXXIMNIHGENYMESLKAADVYSYSLVLWEILSRTTFDGVIQPYQLPFGENVQSDPSFEEMFKVVVEQGLRPNLSEN--IKAQLNPVVKIMEECWHQRPSIRLSMLRVKKSLFNI 1808
TL L D +CTSGSGSGLPFLVQRTVARQI LLEC+GKG++GEVW+G +QGE VAVKIFSSR+E SW RET +YNTV+LRH+NILG+ ASD+ S TQLW++ YH +GSL++YL TL + L++ S A+GL HLH I G QGKPAIAHRD+KSKNILVKKN CCIADLGLAV + + NN VGTKRYMAPE+L+ + CF +S K D++++ LVLWE+ R +G+++ Y+ PF + V +DPSFE+M KVV RPN+ L + K+M+ECW+Q PS RL+ LR+KK+L I
Sbjct: 179 TLADLLDHSCTSGSGSGLPFLVQRTVARQITLLECVGKGRYGEVWRGSWQGENVAVKIFSSRDEKSWFRETELYNTVMLRHENILGFIASDMTSRHSSTQLWLITHYHEMGSLYDYLQLTTLDTVSCLRIVLSIASGLAHLHIEIFGTQGKPAIAHRDLKSKNILVKKNGQCCIADLGLAVM---HSQSTNQLDVGNNPRVGTKRYMAPEVLDETIQVDCF---------------------------------DSYKRVDIWAFGLVLWEVARRMVSNGIVEDYKPPFYDVVPNDPSFEDMRKVVCVDQQRPNIPNRWFSDPTLTSLAKLMKECWYQNPSARLTALRIKKTLTKI 498
BLAST of Receptor protein serine/threonine kinase vs. Ensembl Human
Match: ACVR1 (activin A receptor type 1 [Source:HGNC Symbol;Acc:HGNC:171]) HSP 1 Score: 320.087 bits (819), Expect = 1.189e-100 Identity = 181/356 (50.84%), Postives = 230/356 (64.61%), Query Frame = 3
Query: 759 TLEKLRDDTCTSGSGSGLPFLVQRTVARQINLLECIGKGKFGEVWKGQFQGELVAVKIFXXXXXXXXXXXXNIYNTVLLRHDNILGYYASDLISNSGCTQLWMVMQYHPLGSLHEYLSANTLTVSTVLKLAHSAAAGLCHLHTRIMGLQGKPAIAHRDVKSKNILVKKNLTCCIADLGLAVFPESMGXXXXXXXXXXXRIVGTKRYMAPELLE----LACFLXXXXXXXXXXXXXXXXXXXXXXIMNIHGENYMESLKAADVYSYSLVLWEILSRTTFDGVIQPYQLPFGENVQSDPSFEEMFKVVVEQGLRPNLSEN--IKAQLNPVVKIMEECWHQRPSIRLSMLRVKKSLFNI 1808
TL L D +CTSGSGSGLPFLVQRTVARQI LLEC+GKG++GEVW+G +QGE VAVKIFSSR+E SW RET +YNTV+LRH+NILG+ ASD+ S TQLW++ YH +GSL++YL TL + L++ S A+GL HLH I G QGKPAIAHRD+KSKNILVKKN CCIADLGLAV + + NN VGTKRYMAPE+L+ + CF +S K D++++ LVLWE+ R +G+++ Y+ PF + V +DPSFE+M KVV RPN+ L + K+M+ECW+Q PS RL+ LR+KK+L I
Sbjct: 179 TLADLLDHSCTSGSGSGLPFLVQRTVARQITLLECVGKGRYGEVWRGSWQGENVAVKIFSSRDEKSWFRETELYNTVMLRHENILGFIASDMTSRHSSTQLWLITHYHEMGSLYDYLQLTTLDTVSCLRIVLSIASGLAHLHIEIFGTQGKPAIAHRDLKSKNILVKKNGQCCIADLGLAVM---HSQSTNQLDVGNNPRVGTKRYMAPEVLDETIQVDCF---------------------------------DSYKRVDIWAFGLVLWEVARRMVSNGIVEDYKPPFYDVVPNDPSFEDMRKVVCVDQQRPNIPNRWFSDPTLTSLAKLMKECWYQNPSARLTALRIKKTLTKI 498
BLAST of Receptor protein serine/threonine kinase vs. Ensembl Celegans
Match: daf-1 (Cell surface receptor daf-1 [Source:UniProtKB/Swiss-Prot;Acc:P20792]) HSP 1 Score: 207.608 bits (527), Expect = 1.479e-57 Identity = 131/346 (37.86%), Postives = 191/346 (55.20%), Query Frame = 3
Query: 789 TSGSGSGLPFLVQRTVARQINLLECIGKGKFGEVWKGQFQGELVAVKIFXXXXXXXXXXXXNIYNTVLLRHDNILGYYASDLISNSGCTQLWMVMQYHPLGSLHEYLSANTLTVSTVLKLAHSAAAGLCHLHTRIMGLQ--GKPAIAHRDVKSKNILVKKNLTCCIADLGLAVF-PESMGXXXXXXXXXXXRIVGTKRYMAPELLELACFLXXXXXXXXXXXXXXXXXXXXXXIMNIHGENYMESLKAADVYSYSLVLWEILSRTTFDGVIQPYQ----LPFGENVQSDPSFEEMFKVVVEQGLRPNLSENIK--AQLNPVVKIMEECWHQRPSIRLSMLRVKKSL 1799
TSGSG G L + T+ QI L +G G+FG V +G ++GE VAVK+F++ +E ++ +ET I+ T +LRH N+L Y SD + T+LW+V +YHP GSLH++L NT+ + T L S A+GL LH +I G + KPA+AHRD+KSKNI+VK +LTC I DLGL++ PE ++ +EN GT RY+APE+L ES + ADVYS+SLV+WE L R DG + P + +P+ E DP +MF VV + LRP + K ++ +++I++ CW+ PS R + +K +
Sbjct: 274 TSGSGMGPTTLHKLTIGGQIRLTGRVGSGRFGNVSRGDYRGEAVAVKVFNALDEPAFHKETEIFETRMLRHPNVLRYIGSDRVDTGFVTELWLVTEYHPSGSLHDFLLENTVNIETYYNLMRSTASGLAFLHNQIGGSKESNKPAMAHRDIKSKNIMVKNDLTCAIGDLGLSLSKPEDAASDIIANENYK---CGTVRYLAPEILNSTMQF-----------------------------TVFESYQCADVYSFSLVMWETLCRCE-DGDVLPREAATVIPYIEWTDRDPQDAQMFDVVCTRRLRPTENPLWKDHPEMKHIMEIIKTCWNGNPSARFTSYICRKRM 586
BLAST of Receptor protein serine/threonine kinase vs. Ensembl Celegans
Match: daf-1 (Cell surface receptor daf-1 [Source:UniProtKB/Swiss-Prot;Acc:P20792]) HSP 1 Score: 204.142 bits (518), Expect = 2.654e-56 Identity = 133/348 (38.22%), Postives = 193/348 (55.46%), Query Frame = 3
Query: 789 TSGSGSGLPFLVQRTVARQINLLECIGKGKFGEVWKGQFQGELVAVKIFXXXXXXXXXXXXNIYNTVLLRHDNILGYYASDLISNSGCTQLWMVMQYHPLGSLHEYLSANTLTVSTVLKLAHSAAAGLCHLHTRIMGLQ--GKPAIAHRDVKSKNILVKKNLTCCIADLGLAVF-PESMGXXXXXXXXXXXRIVGTKRYMAPELLELACFLXXXXXXXXXXXXXXXXXXXXXXIMNIHGENYMESLKAADVYSYSLVLWEILSRTTFDGVIQPYQ----LPFGENVQSDPSFEEMFKVVVEQGLRPNLSENIKAQLNP----VVKIMEECWHQRPSIRLSMLRVKKSL 1799
TSGSG G L + T+ QI L +G G+FG V +G ++GE VAVK+F++ +E ++ +ET I+ T +LRH N+L Y SD + T+LW+V +YHP GSLH++L NT+ + T L S A+GL LH +I G + KPA+AHRD+KSKNI+VK +LTC I DLGL++ PE ++ +EN GT RY+APE+L ES + ADVYS+SLV+WE L R DG + P + +P+ E DP +MF VV + LRP +EN + +P +++I++ CW+ PS R + +K +
Sbjct: 274 TSGSGMGPTTLHKLTIGGQIRLTGRVGSGRFGNVSRGDYRGEAVAVKVFNALDEPAFHKETEIFETRMLRHPNVLRYIGSDRVDTGFVTELWLVTEYHPSGSLHDFLLENTVNIETYYNLMRSTASGLAFLHNQIGGSKESNKPAMAHRDIKSKNIMVKNDLTCAIGDLGLSLSKPEDAASDIIANENYK---CGT-RYLAPEILNSTMQF-----------------------------TVFESYQCADVYSFSLVMWETLCRCE-DGDVLPREAATVIPYIEWTDRDPQDAQMFDVVCTRRLRP--TENPLWKDHPEMKHIMEIIKTCWNGNPSARFTSYICRKRM 585
BLAST of Receptor protein serine/threonine kinase vs. Ensembl Celegans
Match: sma-6 (Serine/threonine-protein kinase sma-6 [Source:UniProtKB/Swiss-Prot;Acc:Q09488]) HSP 1 Score: 192.2 bits (487), Expect = 2.745e-52 Identity = 140/431 (32.48%), Postives = 205/431 (47.56%), Query Frame = 3
Query: 792 SGSGSGLPFLVQRTVARQINLLECIGKGKFGEVWKGQFQGELVAVKIFXXXXXXXXXXXXNIYNTVLLRHDNILGYYASDLISNSGC-TQLWMVMQYHPLGSLHEYL-SANTLTVSTVLKLAHSAAAGLCHLHTRIMGLQG--KPAIAHRDVKSKNILVKKNLTCCIADLGLA-------VFPESMGXXXXXXXXXXXRIVGTKRYMAPELLELACFLXXXXXXXXXXXXXXXXXXXXXXIMNIHGENYMESLKAADVYSYSLVLWEI------------------------------------------LSRTTFDG-----VIQPYQLPFGENVQSDPSFEEMFKVVVEQGLR--PNLS-ENIKAQLNPVVKIMEECWHQRPSIRLSMLRVKKSLFNIVMKYSNLSENPNETLRSNVSSDLVTSHSDFS 1901
SGSGSG L+QRTV + + +++ IG+G++GEV K ++G VAVK F + +E SW E ++Y T ++ H+NIL + A+D+ S T++ ++ YH LGSL +YL TLT L+L HS G+ HLH + G KP IAHRD+KSKNI+VK+ CCIADLGLA + PE VGTKRYMAPEL I N K AD+YS +LV+WE+ L +T +G + + PF V +DP+F+EM V+ + +R P+L+ +N+ A LN + K+ME+ WH P R S L++KK + ++ +++ + S LV S ++ S
Sbjct: 247 SGSGSGQAALIQRTVRQDLTIIKTIGQGRYGEVRKALYRGSYVAVKTFYTTDEDSWKNERDVYQTNMINHENILQFVAADIWSEEDSMTKMLLITDYHELGSLSDYLCREETLTTDEALRLIHSCICGIEHLHAAVHGTGSFRKPEIAHRDIKSKNIIVKRPNVCCIADLGLALRYQNDKILPEKFNVQ-----------VGTKRYMAPEL-----------------------------ISNKLNPKDFSQFKMADIYSMALVMWEVAIRVEVNTCEEVLTVDETSPDHSASSGIGESVSSSGNISRMHLQKTNVEGHSTSLKAKQHVPPFDGIVHNDPNFDEMNDVICVRRIRPPPDLAWKNVPA-LNELSKLMEDSWHSIPHFRHSALKLKKEMAELIKNPDRQNQSQRKVEFQQQDSGLVESATNQS 636
BLAST of Receptor protein serine/threonine kinase vs. Ensembl Celegans
Match: daf-4 (Cell surface receptor daf-4 [Source:UniProtKB/Swiss-Prot;Acc:P50488]) HSP 1 Score: 124.405 bits (311), Expect = 1.126e-29 Identity = 104/353 (29.46%), Postives = 168/353 (47.59%), Query Frame = 3
Query: 819 LVQRTVARQINLLECIGKGKFGEVWKGQF-----QGELVAVKIFXXXXXXXXXXXXNIY---NTVLLRHDNILGYYASDLISNSGCTQLWMVMQYHPLGSLHEYLSANTLTVSTVLKLAHSAAAGLCHLHTRIMGLQGKP--AIAHRDVKSKNILVKKNLTCCIADLGLAVFPESMGXXXXXXXXXXXRIVGTKRYMAPELLELACFLXXXXXXXXXXXXXXXXXXXXXXIMNIHGENYMESLKAADVYSYSLVLWEILSRTTFDGVIQP--YQLPFGENVQSDPSFEEMFKVVVEQGLRPNLSENI--KAQLNPVVKIMEECWHQRPSIRLSMLRVKKSLFNIVMKYSNLSE 1835
+V+ I + I KG+FG+V+K Q+ + LVAVK + +++S+ E I+ N + +I+ + ++ I + + W+V ++H SL+E L N +++++ ++ S GL LH G P I HRD+KSKNILVK ++T CIAD GLA + + +++ VGTKRYM+PE+LE A E + KA DVYS LV+WE++SRT +P YQ+PF + + DP+ M VV + RP + I ++ + K+ EE W R++ ++N +M + SE
Sbjct: 78 MVETPKELPITDFQLISKGRFGKVFKAQYTPDSGEKRLVAVKKLNEFQKASFLAEKRIFDELNEYPKWYKSIVEFVCAEKIGD----EYWIVTEFHERLSLYELLKNNVISITSANRIIMSMIDGLQFLHDDRPYFFGHPKKPIIHRDIKSKNILVKSDMTTCIADFGLARI-----YSYDIEQSDLLGQVGTKRYMSPEMLEGAT------------------------------EFTPTAFKAMDVYSMGLVMWEVISRTKLHQTDEPPNYQMPF-QVIGFDPTIGLMRNYVVSKKERPQWRDEIIKHEYMSLLKKVTEEMWDPEACARITAGCAFARVWNHIMSSPDSSE 390
BLAST of Receptor protein serine/threonine kinase vs. Ensembl Celegans
Match: daf-4 (Cell surface receptor daf-4 [Source:UniProtKB/Swiss-Prot;Acc:P50488]) HSP 1 Score: 124.79 bits (312), Expect = 1.516e-29 Identity = 104/353 (29.46%), Postives = 168/353 (47.59%), Query Frame = 3
Query: 819 LVQRTVARQINLLECIGKGKFGEVWKGQF-----QGELVAVKIFXXXXXXXXXXXXNIY---NTVLLRHDNILGYYASDLISNSGCTQLWMVMQYHPLGSLHEYLSANTLTVSTVLKLAHSAAAGLCHLHTRIMGLQGKP--AIAHRDVKSKNILVKKNLTCCIADLGLAVFPESMGXXXXXXXXXXXRIVGTKRYMAPELLELACFLXXXXXXXXXXXXXXXXXXXXXXIMNIHGENYMESLKAADVYSYSLVLWEILSRTTFDGVIQP--YQLPFGENVQSDPSFEEMFKVVVEQGLRPNLSENI--KAQLNPVVKIMEECWHQRPSIRLSMLRVKKSLFNIVMKYSNLSE 1835
+V+ I + I KG+FG+V+K Q+ + LVAVK + +++S+ E I+ N + +I+ + ++ I + + W+V ++H SL+E L N +++++ ++ S GL LH G P I HRD+KSKNILVK ++T CIAD GLA + + +++ VGTKRYM+PE+LE A E + KA DVYS LV+WE++SRT +P YQ+PF + + DP+ M VV + RP + I ++ + K+ EE W R++ ++N +M + SE
Sbjct: 145 MVETPKELPITDFQLISKGRFGKVFKAQYTPDSGEKRLVAVKKLNEFQKASFLAEKRIFDELNEYPKWYKSIVEFVCAEKIGD----EYWIVTEFHERLSLYELLKNNVISITSANRIIMSMIDGLQFLHDDRPYFFGHPKKPIIHRDIKSKNILVKSDMTTCIADFGLARI-----YSYDIEQSDLLGQVGTKRYMSPEMLEGAT------------------------------EFTPTAFKAMDVYSMGLVMWEVISRTKLHQTDEPPNYQMPF-QVIGFDPTIGLMRNYVVSKKERPQWRDEIIKHEYMSLLKKVTEEMWDPEACARITAGCAFARVWNHIMSSPDSSE 457
BLAST of Receptor protein serine/threonine kinase vs. Ensembl Fly
Match: sax (gene:FBgn0003317 transcript:FBtr0088833) HSP 1 Score: 297.36 bits (760), Expect = 6.157e-92 Identity = 168/368 (45.65%), Postives = 232/368 (63.04%), Query Frame = 3
Query: 726 VISATDSGRGVTLEKLRDDTCTSGSGSGLPFLVQRTVARQINLLECIGKGKFGEVWKGQFQGELVAVKIFXXXXXXXXXXXXNIYNTVLLRHDNILGYYASDLISNSGCTQLWMVMQYHPLGSLHEYLSANTLTVSTVLKLAHSAAAGLCHLHTRIMGLQGKPAIAHRDVKSKNILVKKNLTCCIADLGLAVFPESMGXXXXXXXXXXXRIVGTKRYMAPELL----ELACFLXXXXXXXXXXXXXXXXXXXXXXIMNIHGENYMESLKAADVYSYSLVLWEILSRTTFDGVIQPYQLPFGENVQSDPSFEEMFKVVVEQGLRPNLSENIKAQ--LNPVVKIMEECWHQRPSIRLSMLRVKKSLFNIV 1811
++ AT +G TL + + TSGSGSGLP LVQRT+A+Q+ L+ECIG+GK+GEVW+G + GE +AVKIF SR+E SW RET IY+T+LLRH+NILG+ SD+ S + CTQLW++ Y+PLGSL ++L+ N L+ + ++ + S A GL HLHT I G QGKPA+AHRD+KSKNILV N +C IAD GLAV + + + NN VGTKRYMAPE+L +L CF E+L+ D+Y++ LVLWE+ RT G+ + Y++PF + V DPSFE+M KVV RP++ + + + K+M+ECWHQ P +RL LR+KK++ +
Sbjct: 190 LLRATSAGDS-TLREYLQHSVTSGSGSGLPLLVQRTLAKQVTLIECIGRGKYGEVWRGHWHGESIAVKIFFSRDEESWKRETEIYSTILLRHENILGFIGSDMTSRNSCTQLWLMTHYYPLGSLFDHLNRNALSHNDMVWICLSIANGLVHLHTEIFGKQGKPAMAHRDLKSKNILVTSNGSCVIADFGLAV---THSHVTGQLDLGNNPKVGTKRYMAPEVLDESIDLECF---------------------------------EALRRTDIYAFGLVLWEVCRRTISCGIAEEYKVPFYDVVPMDPSFEDMRKVVCIDNYRPSIPNRWSSDSLMTGMSKLMKECWHQNPDVRLPALRIKKTIHKLA 520
BLAST of Receptor protein serine/threonine kinase vs. Ensembl Fly
Match: sax (gene:FBgn0003317 transcript:FBtr0308825) HSP 1 Score: 297.745 bits (761), Expect = 1.672e-91 Identity = 168/368 (45.65%), Postives = 232/368 (63.04%), Query Frame = 3
Query: 726 VISATDSGRGVTLEKLRDDTCTSGSGSGLPFLVQRTVARQINLLECIGKGKFGEVWKGQFQGELVAVKIFXXXXXXXXXXXXNIYNTVLLRHDNILGYYASDLISNSGCTQLWMVMQYHPLGSLHEYLSANTLTVSTVLKLAHSAAAGLCHLHTRIMGLQGKPAIAHRDVKSKNILVKKNLTCCIADLGLAVFPESMGXXXXXXXXXXXRIVGTKRYMAPELL----ELACFLXXXXXXXXXXXXXXXXXXXXXXIMNIHGENYMESLKAADVYSYSLVLWEILSRTTFDGVIQPYQLPFGENVQSDPSFEEMFKVVVEQGLRPNLSENIKAQ--LNPVVKIMEECWHQRPSIRLSMLRVKKSLFNIV 1811
++ AT +G TL + + TSGSGSGLP LVQRT+A+Q+ L+ECIG+GK+GEVW+G + GE +AVKIF SR+E SW RET IY+T+LLRH+NILG+ SD+ S + CTQLW++ Y+PLGSL ++L+ N L+ + ++ + S A GL HLHT I G QGKPA+AHRD+KSKNILV N +C IAD GLAV + + + NN VGTKRYMAPE+L +L CF E+L+ D+Y++ LVLWE+ RT G+ + Y++PF + V DPSFE+M KVV RP++ + + + K+M+ECWHQ P +RL LR+KK++ +
Sbjct: 237 LLRATSAGDS-TLREYLQHSVTSGSGSGLPLLVQRTLAKQVTLIECIGRGKYGEVWRGHWHGESIAVKIFFSRDEESWKRETEIYSTILLRHENILGFIGSDMTSRNSCTQLWLMTHYYPLGSLFDHLNRNALSHNDMVWICLSIANGLVHLHTEIFGKQGKPAMAHRDLKSKNILVTSNGSCVIADFGLAV---THSHVTGQLDLGNNPKVGTKRYMAPEVLDESIDLECF---------------------------------EALRRTDIYAFGLVLWEVCRRTISCGIAEEYKVPFYDVVPMDPSFEDMRKVVCIDNYRPSIPNRWSSDSLMTGMSKLMKECWHQNPDVRLPALRIKKTIHKLA 567
BLAST of Receptor protein serine/threonine kinase vs. Ensembl Fly
Match: sax (gene:FBgn0003317 transcript:FBtr0088832) HSP 1 Score: 297.36 bits (760), Expect = 1.765e-91 Identity = 168/368 (45.65%), Postives = 232/368 (63.04%), Query Frame = 3
Query: 726 VISATDSGRGVTLEKLRDDTCTSGSGSGLPFLVQRTVARQINLLECIGKGKFGEVWKGQFQGELVAVKIFXXXXXXXXXXXXNIYNTVLLRHDNILGYYASDLISNSGCTQLWMVMQYHPLGSLHEYLSANTLTVSTVLKLAHSAAAGLCHLHTRIMGLQGKPAIAHRDVKSKNILVKKNLTCCIADLGLAVFPESMGXXXXXXXXXXXRIVGTKRYMAPELL----ELACFLXXXXXXXXXXXXXXXXXXXXXXIMNIHGENYMESLKAADVYSYSLVLWEILSRTTFDGVIQPYQLPFGENVQSDPSFEEMFKVVVEQGLRPNLSENIKAQ--LNPVVKIMEECWHQRPSIRLSMLRVKKSLFNIV 1811
++ AT +G TL + + TSGSGSGLP LVQRT+A+Q+ L+ECIG+GK+GEVW+G + GE +AVKIF SR+E SW RET IY+T+LLRH+NILG+ SD+ S + CTQLW++ Y+PLGSL ++L+ N L+ + ++ + S A GL HLHT I G QGKPA+AHRD+KSKNILV N +C IAD GLAV + + + NN VGTKRYMAPE+L +L CF E+L+ D+Y++ LVLWE+ RT G+ + Y++PF + V DPSFE+M KVV RP++ + + + K+M+ECWHQ P +RL LR+KK++ +
Sbjct: 225 LLRATSAGDS-TLREYLQHSVTSGSGSGLPLLVQRTLAKQVTLIECIGRGKYGEVWRGHWHGESIAVKIFFSRDEESWKRETEIYSTILLRHENILGFIGSDMTSRNSCTQLWLMTHYYPLGSLFDHLNRNALSHNDMVWICLSIANGLVHLHTEIFGKQGKPAMAHRDLKSKNILVTSNGSCVIADFGLAV---THSHVTGQLDLGNNPKVGTKRYMAPEVLDESIDLECF---------------------------------EALRRTDIYAFGLVLWEVCRRTISCGIAEEYKVPFYDVVPMDPSFEDMRKVVCIDNYRPSIPNRWSSDSLMTGMSKLMKECWHQNPDVRLPALRIKKTIHKLA 555
BLAST of Receptor protein serine/threonine kinase vs. Ensembl Fly
Match: babo (gene:FBgn0011300 transcript:FBtr0300599) HSP 1 Score: 286.189 bits (731), Expect = 4.512e-87 Identity = 169/346 (48.84%), Postives = 224/346 (64.74%), Query Frame = 3
Query: 789 TSGSGS-GLPFLVQRTVARQINLLECIGKGKFGEVWKGQFQGELVAVKIFXXXXXXXXXXXXNIYNTVLLRHDNILGYYASDLISNSGCTQLWMVMQYHPLGSLHEYLSANTLTVSTVLKLAHSAAAGLCHLHTRIMGLQGKPAIAHRDVKSKNILVKKNLTCCIADLGLAVFPESMGXXXXXXXXXXXRIVGTKRYMAPELLELACFLXXXXXXXXXXXXXXXXXXXXXXIMNIHGENYMESLKAADVYSYSLVLWEILSRTTFDGVIQPYQLPFGENVQSDPSFEEMFKVVVEQGLRPNLSENIKAQ--LNPVVKIMEECWHQRPSIRLSMLRVKKSLFNIVMK 1817
TSGSGS GLP LVQR++ARQ+ L IGKG+FGEVW+G+++GE VAVKIFSSREE SW RE IY TV+LRH+NILG+ A+D N TQLW+V YH GSL +YL+ + + +T+L ++ S A GL HLH I+G +GKPAIAHRD+KSKNILVK NL+C I DLGLAV + N+ + + +R VGTKRYMAPE+L+ + MN + + +S K ADVY++ L+LWEI R + YQLP+ + VQ DPS EEM KVV + RPN+ A L+ + K+M+ECW+ P RL+ LR+KK+L +I ++
Sbjct: 277 TSGSGSAGLPLLVQRSIARQVQLCHVIGKGRFGEVWRGRWRGENVAVKIFSSREECSWFREAEIYQTVMLRHENILGFIAADNKDNGTWTQLWLVTDYHENGSLFDYLTTHPVDTNTMLNMSLSIATGLAHLHMDIVGTRGKPAIAHRDLKSKNILVKSNLSCAIGDLGLAV--RHVEKNDSVDIPSTHR-VGTKRYMAPEVLDES--------------------------MN---DQHFDSYKRADVYAFGLILWEIARRCNMGMIYDEYQLPYYDVVQPDPSIEEMKKVVCIEKCRPNIPNRWHASDVLHNMAKVMKECWYPNPVARLTALRIKKTLASISVE 590
BLAST of Receptor protein serine/threonine kinase vs. Ensembl Fly
Match: babo (gene:FBgn0011300 transcript:FBtr0088659) HSP 1 Score: 286.574 bits (732), Expect = 4.768e-87 Identity = 169/346 (48.84%), Postives = 224/346 (64.74%), Query Frame = 3
Query: 789 TSGSGS-GLPFLVQRTVARQINLLECIGKGKFGEVWKGQFQGELVAVKIFXXXXXXXXXXXXNIYNTVLLRHDNILGYYASDLISNSGCTQLWMVMQYHPLGSLHEYLSANTLTVSTVLKLAHSAAAGLCHLHTRIMGLQGKPAIAHRDVKSKNILVKKNLTCCIADLGLAVFPESMGXXXXXXXXXXXRIVGTKRYMAPELLELACFLXXXXXXXXXXXXXXXXXXXXXXIMNIHGENYMESLKAADVYSYSLVLWEILSRTTFDGVIQPYQLPFGENVQSDPSFEEMFKVVVEQGLRPNLSENIKAQ--LNPVVKIMEECWHQRPSIRLSMLRVKKSLFNIVMK 1817
TSGSGS GLP LVQR++ARQ+ L IGKG+FGEVW+G+++GE VAVKIFSSREE SW RE IY TV+LRH+NILG+ A+D N TQLW+V YH GSL +YL+ + + +T+L ++ S A GL HLH I+G +GKPAIAHRD+KSKNILVK NL+C I DLGLAV + N+ + + +R VGTKRYMAPE+L+ + MN + + +S K ADVY++ L+LWEI R + YQLP+ + VQ DPS EEM KVV + RPN+ A L+ + K+M+ECW+ P RL+ LR+KK+L +I ++
Sbjct: 283 TSGSGSAGLPLLVQRSIARQVQLCHVIGKGRFGEVWRGRWRGENVAVKIFSSREECSWFREAEIYQTVMLRHENILGFIAADNKDNGTWTQLWLVTDYHENGSLFDYLTTHPVDTNTMLNMSLSIATGLAHLHMDIVGTRGKPAIAHRDLKSKNILVKSNLSCAIGDLGLAV--RHVEKNDSVDIPSTHR-VGTKRYMAPEVLDES--------------------------MN---DQHFDSYKRADVYAFGLILWEIARRCNMGMIYDEYQLPYYDVVQPDPSIEEMKKVVCIEKCRPNIPNRWHASDVLHNMAKVMKECWYPNPVARLTALRIKKTLASISVE 596
BLAST of Receptor protein serine/threonine kinase vs. Ensembl Zebrafish
Match: acvr1l (activin A receptor, type 1 like [Source:ZFIN;Acc:ZDB-GENE-990415-9]) HSP 1 Score: 320.857 bits (821), Expect = 3.909e-101 Identity = 182/356 (51.12%), Postives = 238/356 (66.85%), Query Frame = 3
Query: 759 TLEKLRDDTCTSGSGSGLPFLVQRTVARQINLLECIGKGKFGEVWKGQFQGELVAVKIFXXXXXXXXXXXXNIYNTVLLRHDNILGYYASDLISNSGCTQLWMVMQYHPLGSLHEYLSANTLTVSTVLKLAHSAAAGLCHLHTRIMGLQGKPAIAHRDVKSKNILVKKNLTCCIADLGLAVFPESMGXXXXXXXXXXXRIVGTKRYMAPELL----ELACFLXXXXXXXXXXXXXXXXXXXXXXIMNIHGENYMESLKAADVYSYSLVLWEILSRTTFDGVIQPYQLPFGENVQSDPSFEEMFKVVVEQGLRPNLSEN--IKAQLNPVVKIMEECWHQRPSIRLSMLRVKKSLFNI 1808
TL L D +CTSGSGSGLPFLVQRTVARQI+L+EC+GKG++GEVW+GQ+QGE VAVKIFSSR+E SW RET IYNTVLLRH+NILG+ ASD+ S + TQLW++ YH GSL++YL + ++ L +A S A+GL HLHT I G +GKPAIAHRD+KSKNILVKK+L CCIADLGLAV + ++ + NN VGTKRYMAPE+L + CF ++ K D++++ LVLWEI RT +G+++ Y+ PF + V +DPSF++M KVV + RP + L+ +VK+M+ECW+Q PS RL+ LR+KK+L I
Sbjct: 176 TLADLMDHSCTSGSGSGLPFLVQRTVARQISLVECVGKGRYGEVWRGQWQGENVAVKIFSSRDEKSWFRETEIYNTVLLRHENILGFMASDMTSRNSSTQLWLITHYHENGSLYDYLQRVAVEMADGLHMAASIASGLVHLHTEIFGTEGKPAIAHRDLKSKNILVKKDLQCCIADLGLAV---THTQSDNQLDVGNNPKVGTKRYMAPEVLDETIQTDCF---------------------------------DAYKRVDIWAFGLVLWEIARRTISNGIVEEYKPPFYDLVPNDPSFDDMRKVVCVEQQRPFIPNRWFSDPTLSALVKLMKECWYQNPSARLTALRIKKTLDKI 495
BLAST of Receptor protein serine/threonine kinase vs. Ensembl Zebrafish
Match: acvr1l (activin A receptor, type 1 like [Source:ZFIN;Acc:ZDB-GENE-990415-9]) HSP 1 Score: 320.857 bits (821), Expect = 3.909e-101 Identity = 182/356 (51.12%), Postives = 238/356 (66.85%), Query Frame = 3
Query: 759 TLEKLRDDTCTSGSGSGLPFLVQRTVARQINLLECIGKGKFGEVWKGQFQGELVAVKIFXXXXXXXXXXXXNIYNTVLLRHDNILGYYASDLISNSGCTQLWMVMQYHPLGSLHEYLSANTLTVSTVLKLAHSAAAGLCHLHTRIMGLQGKPAIAHRDVKSKNILVKKNLTCCIADLGLAVFPESMGXXXXXXXXXXXRIVGTKRYMAPELL----ELACFLXXXXXXXXXXXXXXXXXXXXXXIMNIHGENYMESLKAADVYSYSLVLWEILSRTTFDGVIQPYQLPFGENVQSDPSFEEMFKVVVEQGLRPNLSEN--IKAQLNPVVKIMEECWHQRPSIRLSMLRVKKSLFNI 1808
TL L D +CTSGSGSGLPFLVQRTVARQI+L+EC+GKG++GEVW+GQ+QGE VAVKIFSSR+E SW RET IYNTVLLRH+NILG+ ASD+ S + TQLW++ YH GSL++YL + ++ L +A S A+GL HLHT I G +GKPAIAHRD+KSKNILVKK+L CCIADLGLAV + ++ + NN VGTKRYMAPE+L + CF ++ K D++++ LVLWEI RT +G+++ Y+ PF + V +DPSF++M KVV + RP + L+ +VK+M+ECW+Q PS RL+ LR+KK+L I
Sbjct: 176 TLADLMDHSCTSGSGSGLPFLVQRTVARQISLVECVGKGRYGEVWRGQWQGENVAVKIFSSRDEKSWFRETEIYNTVLLRHENILGFMASDMTSRNSSTQLWLITHYHENGSLYDYLQRVAVEMADGLHMAASIASGLVHLHTEIFGTEGKPAIAHRDLKSKNILVKKDLQCCIADLGLAV---THTQSDNQLDVGNNPKVGTKRYMAPEVLDETIQTDCF---------------------------------DAYKRVDIWAFGLVLWEIARRTISNGIVEEYKPPFYDLVPNDPSFDDMRKVVCVEQQRPFIPNRWFSDPTLSALVKLMKECWYQNPSARLTALRIKKTLDKI 495
BLAST of Receptor protein serine/threonine kinase vs. Ensembl Zebrafish
Match: acvrl1 (activin A receptor like type 1 [Source:ZFIN;Acc:ZDB-GENE-021003-1]) HSP 1 Score: 316.235 bits (809), Expect = 1.816e-99 Identity = 178/354 (50.28%), Postives = 231/354 (65.25%), Query Frame = 3
Query: 744 SGRGVTLEKLRDDTCTSGSGSGLPFLVQRTVARQINLLECIGKGKFGEVWKGQFQGELVAVKIFXXXXXXXXXXXXNIYNTVLLRHDNILGYYASDLISNSGCTQLWMVMQYHPLGSLHEYLSANTLTVSTVLKLAHSAAAGLCHLHTRIMGLQGKPAIAHRDVKSKNILVKKNLTCCIADLGLAVFPESMGXXXXXXXXXXXRIVGTKRYMAPELLELACFLXXXXXXXXXXXXXXXXXXXXXXIMNIHGENYMESLKAADVYSYSLVLWEILSRTTFDGVIQPYQLPFGENVQSDPSFEEMFKVVVEQGLRPNLSENIKAQ--LNPVVKIMEECWHQRPSIRLSMLRVKKSL 1799
SG T + D+ CTSGSG+GLP+LVQRT+ARQI+L+EC+GKG++GEVW+G + GE VAVKIFSSR+E SW RET IYNTV LRH+NILG+ ASD+ S + TQLW+V +H LGSL+++L +TL L++ S A+GL HLHT I+ QGKPAIAHRD+KS+NILVK+N CCIADLGLAV + + N VGTKRYMAPE+L+ + + ES K D+++ LVLWEI RT +G+++ Y+ PF + V SDPSFEEM KVV RP+L + + L+ + KIM+ECW Q PS RL+ LRV+KSL
Sbjct: 160 SGGDPTYGDIFDEFCTSGSGTGLPYLVQRTMARQISLVECVGKGRYGEVWRGTWMGESVAVKIFSSRDEQSWFRETEIYNTVQLRHENILGFIASDMTSKNSSTQLWLVTHFHELGSLYDFLQYSTLDPEGCLRMCLSIASGLVHLHTEILSTQGKPAIAHRDLKSRNILVKRNGQCCIADLGLAVI---HSQSTDYLDVGTNPRVGTKRYMAPEVLDETIRV-----------------------------DVFESYKQTDIWALGLVLWEITRRTIVNGIVEEYRPPFFDMVPSDPSFEEMKKVVCVDQHRPSLHNRLHSHPILSAIAKIMKECWFQSPSARLTALRVRKSL 481
BLAST of Receptor protein serine/threonine kinase vs. Ensembl Zebrafish
Match: acvrl1 (activin A receptor like type 1 [Source:ZFIN;Acc:ZDB-GENE-021003-1]) HSP 1 Score: 316.235 bits (809), Expect = 2.134e-99 Identity = 178/354 (50.28%), Postives = 231/354 (65.25%), Query Frame = 3
Query: 744 SGRGVTLEKLRDDTCTSGSGSGLPFLVQRTVARQINLLECIGKGKFGEVWKGQFQGELVAVKIFXXXXXXXXXXXXNIYNTVLLRHDNILGYYASDLISNSGCTQLWMVMQYHPLGSLHEYLSANTLTVSTVLKLAHSAAAGLCHLHTRIMGLQGKPAIAHRDVKSKNILVKKNLTCCIADLGLAVFPESMGXXXXXXXXXXXRIVGTKRYMAPELLELACFLXXXXXXXXXXXXXXXXXXXXXXIMNIHGENYMESLKAADVYSYSLVLWEILSRTTFDGVIQPYQLPFGENVQSDPSFEEMFKVVVEQGLRPNLSENIKAQ--LNPVVKIMEECWHQRPSIRLSMLRVKKSL 1799
SG T + D+ CTSGSG+GLP+LVQRT+ARQI+L+EC+GKG++GEVW+G + GE VAVKIFSSR+E SW RET IYNTV LRH+NILG+ ASD+ S + TQLW+V +H LGSL+++L +TL L++ S A+GL HLHT I+ QGKPAIAHRD+KS+NILVK+N CCIADLGLAV + + N VGTKRYMAPE+L+ + + ES K D+++ LVLWEI RT +G+++ Y+ PF + V SDPSFEEM KVV RP+L + + L+ + KIM+ECW Q PS RL+ LRV+KSL
Sbjct: 163 SGGDPTYGDIFDEFCTSGSGTGLPYLVQRTMARQISLVECVGKGRYGEVWRGTWMGESVAVKIFSSRDEQSWFRETEIYNTVQLRHENILGFIASDMTSKNSSTQLWLVTHFHELGSLYDFLQYSTLDPEGCLRMCLSIASGLVHLHTEILSTQGKPAIAHRDLKSRNILVKRNGQCCIADLGLAVI---HSQSTDYLDVGTNPRVGTKRYMAPEVLDETIRV-----------------------------DVFESYKQTDIWALGLVLWEITRRTIVNGIVEEYRPPFFDMVPSDPSFEEMKKVVCVDQHRPSLHNRLHSHPILSAIAKIMKECWFQSPSARLTALRVRKSL 484
BLAST of Receptor protein serine/threonine kinase vs. Ensembl Zebrafish
Match: tgfbr1b (transforming growth factor, beta receptor 1 b [Source:ZFIN;Acc:ZDB-GENE-091027-1]) HSP 1 Score: 315.849 bits (808), Expect = 3.200e-99 Identity = 185/351 (52.71%), Postives = 231/351 (65.81%), Query Frame = 3
Query: 753 GVTLEKLRDDTCTSGSGSGLPFLVQRTVARQINLLECIGKGKFGEVWKGQFQGELVAVKIFXXXXXXXXXXXXNIYNTVLLRHDNILGYYASDLISNSGCTQLWMVMQYHPLGSLHEYLSANTLTVSTVLKLAHSAAAGLCHLHTRIMGLQGKPAIAHRDVKSKNILVKKNLTCCIADLGLAVFPESMGXXXXXXXXXXXRIVGTKRYMAPELLELACFLXXXXXXXXXXXXXXXXXXXXXXIMNIHGENYMESLKAADVYSYSLVLWEILSRTTFDGVIQPYQLPFGENVQSDPSFEEMFKVVVEQGLRPNLSENIKA--QLNPVVKIMEECWHQRPSIRLSMLRVKKSL 1799
G TL+ L D TSGSGSGLP LVQRT+AR I L E IGKG+FGEVW+G+++GE VAVKIFSSREE SW RE IY TV+LRH+NILG+ A+D N TQLW+V YH GSL +YL+ T+TV ++KL+ S A+GL HLH I+G QGKPAIAHRD+KSKNILVKKN TCCIADLGLAV +S + N VGTKRYMAPE+L+ + +N+ + ES K AD+Y+ LV WEI SR + G+ + YQLP+ + VQSDPS EEM +VV EQ LRPN+ ++ L + KIM ECW+ + RL+ LR+KK+L
Sbjct: 176 GTTLKDLIYDMTTSGSGSGLPLLVQRTIARTIILQESIGKGRFGEVWRGRWRGEEVAVKIFSSREERSWFREAEIYQTVMLRHENILGFIAADNKDNGTWTQLWLVSDYHEHGSLFDYLNRYTVTVEGMIKLSLSTASGLAHLHMEIVGTQGKPAIAHRDLKSKNILVKKNGTCCIADLGLAVRHDS---ATDTIDIAPNHRVGTKRYMAPEVLDDS--------------------------INM---KHFESFKRADIYAMGLVFWEIASRCSIGGIHEDYQLPYHDLVQSDPSVEEMRRVVCEQKLRPNIPNRWQSCEALRVMAKIMRECWYANGAARLTALRIKKTL 494
BLAST of Receptor protein serine/threonine kinase vs. Ensembl Xenopus
Match: acvr1 (activin A receptor type 1 [Source:NCBI gene;Acc:550111]) HSP 1 Score: 323.168 bits (827), Expect = 2.227e-102 Identity = 181/356 (50.84%), Postives = 230/356 (64.61%), Query Frame = 3
Query: 759 TLEKLRDDTCTSGSGSGLPFLVQRTVARQINLLECIGKGKFGEVWKGQFQGELVAVKIFXXXXXXXXXXXXNIYNTVLLRHDNILGYYASDLISNSGCTQLWMVMQYHPLGSLHEYLSANTLTVSTVLKLAHSAAAGLCHLHTRIMGLQGKPAIAHRDVKSKNILVKKNLTCCIADLGLAVFPESMGXXXXXXXXXXXRIVGTKRYMAPELLE----LACFLXXXXXXXXXXXXXXXXXXXXXXIMNIHGENYMESLKAADVYSYSLVLWEILSRTTFDGVIQPYQLPFGENVQSDPSFEEMFKVVVEQGLRPNLSEN--IKAQLNPVVKIMEECWHQRPSIRLSMLRVKKSLFNI 1808
TL ++ D +CTSGSGSGLPFLVQRTVARQI L EC+GKG++GEVW+G +QGE VAVKIFSSR+E SW RET +YNTVLLRH+NILG+ ASD+ S + TQLW++ YH LGSL++YL TL T L++ S A+GL HLH I G QGKPAI+HRD+KSKN+LVKKN CCIADLGLAV N + N VGTKRYMAPE+L+ + CF +S K D+Y++ LVLWE+ R +G+++ Y+ PF + V +DPSFE+M KVV RPN+ L + K+M+ECW+Q PS RL+ LR+KK+L I
Sbjct: 138 TLAEMLDHSCTSGSGSGLPFLVQRTVARQITLAECVGKGRYGEVWRGLWQGESVAVKIFSSRDEKSWFRETELYNTVLLRHENILGFIASDMTSRNSSTQLWLITHYHELGSLYDYLQVTTLDSVTCLRIVLSIASGLAHLHVEIFGTQGKPAISHRDLKSKNVLVKKNGQCCIADLGLAVMHSQTTNQLDVGNNPR---VGTKRYMAPEVLDETIQVDCF---------------------------------DSYKRVDIYAFGLVLWEVARRMVSNGIVEEYKPPFYDVVPNDPSFEDMKKVVCVDQQRPNIPNRWFSDPTLTALAKLMKECWYQNPSARLTALRIKKTLTKI 457
BLAST of Receptor protein serine/threonine kinase vs. Ensembl Xenopus
Match: acvr1 (activin A receptor type 1 [Source:NCBI gene;Acc:550111]) HSP 1 Score: 323.939 bits (829), Expect = 3.619e-102 Identity = 181/356 (50.84%), Postives = 230/356 (64.61%), Query Frame = 3
Query: 759 TLEKLRDDTCTSGSGSGLPFLVQRTVARQINLLECIGKGKFGEVWKGQFQGELVAVKIFXXXXXXXXXXXXNIYNTVLLRHDNILGYYASDLISNSGCTQLWMVMQYHPLGSLHEYLSANTLTVSTVLKLAHSAAAGLCHLHTRIMGLQGKPAIAHRDVKSKNILVKKNLTCCIADLGLAVFPESMGXXXXXXXXXXXRIVGTKRYMAPELL----ELACFLXXXXXXXXXXXXXXXXXXXXXXIMNIHGENYMESLKAADVYSYSLVLWEILSRTTFDGVIQPYQLPFGENVQSDPSFEEMFKVVVEQGLRPNLSEN--IKAQLNPVVKIMEECWHQRPSIRLSMLRVKKSLFNI 1808
TL ++ D +CTSGSGSGLPFLVQRTVARQI L EC+GKG++GEVW+G +QGE VAVKIFSSR+E SW RET +YNTVLLRH+NILG+ ASD+ S + TQLW++ YH LGSL++YL TL T L++ S A+GL HLH I G QGKPAI+HRD+KSKN+LVKKN CCIADLGLAV N + N VGTKRYMAPE+L ++ CF +S K D+Y++ LVLWE+ R +G+++ Y+ PF + V +DPSFE+M KVV RPN+ L + K+M+ECW+Q PS RL+ LR+KK+L I
Sbjct: 178 TLAEMLDHSCTSGSGSGLPFLVQRTVARQITLAECVGKGRYGEVWRGLWQGESVAVKIFSSRDEKSWFRETELYNTVLLRHENILGFIASDMTSRNSSTQLWLITHYHELGSLYDYLQVTTLDSVTCLRIVLSIASGLAHLHVEIFGTQGKPAISHRDLKSKNVLVKKNGQCCIADLGLAVMHSQTTNQLDVGNNPR---VGTKRYMAPEVLDETIQVDCF---------------------------------DSYKRVDIYAFGLVLWEVARRMVSNGIVEEYKPPFYDVVPNDPSFEDMKKVVCVDQQRPNIPNRWFSDPTLTALAKLMKECWYQNPSARLTALRIKKTLTKI 497
BLAST of Receptor protein serine/threonine kinase vs. Ensembl Xenopus
Match: acvr1 (activin A receptor type 1 [Source:NCBI gene;Acc:550111]) HSP 1 Score: 323.939 bits (829), Expect = 3.961e-102 Identity = 181/356 (50.84%), Postives = 230/356 (64.61%), Query Frame = 3
Query: 759 TLEKLRDDTCTSGSGSGLPFLVQRTVARQINLLECIGKGKFGEVWKGQFQGELVAVKIFXXXXXXXXXXXXNIYNTVLLRHDNILGYYASDLISNSGCTQLWMVMQYHPLGSLHEYLSANTLTVSTVLKLAHSAAAGLCHLHTRIMGLQGKPAIAHRDVKSKNILVKKNLTCCIADLGLAVFPESMGXXXXXXXXXXXRIVGTKRYMAPELL----ELACFLXXXXXXXXXXXXXXXXXXXXXXIMNIHGENYMESLKAADVYSYSLVLWEILSRTTFDGVIQPYQLPFGENVQSDPSFEEMFKVVVEQGLRPNLSEN--IKAQLNPVVKIMEECWHQRPSIRLSMLRVKKSLFNI 1808
TL ++ D +CTSGSGSGLPFLVQRTVARQI L EC+GKG++GEVW+G +QGE VAVKIFSSR+E SW RET +YNTVLLRH+NILG+ ASD+ S + TQLW++ YH LGSL++YL TL T L++ S A+GL HLH I G QGKPAI+HRD+KSKN+LVKKN CCIADLGLAV N + N VGTKRYMAPE+L ++ CF +S K D+Y++ LVLWE+ R +G+++ Y+ PF + V +DPSFE+M KVV RPN+ L + K+M+ECW+Q PS RL+ LR+KK+L I
Sbjct: 176 TLAEMLDHSCTSGSGSGLPFLVQRTVARQITLAECVGKGRYGEVWRGLWQGESVAVKIFSSRDEKSWFRETELYNTVLLRHENILGFIASDMTSRNSSTQLWLITHYHELGSLYDYLQVTTLDSVTCLRIVLSIASGLAHLHVEIFGTQGKPAISHRDLKSKNVLVKKNGQCCIADLGLAVMHSQTTNQLDVGNNPR---VGTKRYMAPEVLDETIQVDCF---------------------------------DSYKRVDIYAFGLVLWEVARRMVSNGIVEEYKPPFYDVVPNDPSFEDMKKVVCVDQQRPNIPNRWFSDPTLTALAKLMKECWYQNPSARLTALRIKKTLTKI 495
BLAST of Receptor protein serine/threonine kinase vs. Ensembl Xenopus
Match: acvr1 (activin A receptor type 1 [Source:NCBI gene;Acc:550111]) HSP 1 Score: 323.939 bits (829), Expect = 4.255e-102 Identity = 181/356 (50.84%), Postives = 230/356 (64.61%), Query Frame = 3
Query: 759 TLEKLRDDTCTSGSGSGLPFLVQRTVARQINLLECIGKGKFGEVWKGQFQGELVAVKIFXXXXXXXXXXXXNIYNTVLLRHDNILGYYASDLISNSGCTQLWMVMQYHPLGSLHEYLSANTLTVSTVLKLAHSAAAGLCHLHTRIMGLQGKPAIAHRDVKSKNILVKKNLTCCIADLGLAVFPESMGXXXXXXXXXXXRIVGTKRYMAPELL----ELACFLXXXXXXXXXXXXXXXXXXXXXXIMNIHGENYMESLKAADVYSYSLVLWEILSRTTFDGVIQPYQLPFGENVQSDPSFEEMFKVVVEQGLRPNLSEN--IKAQLNPVVKIMEECWHQRPSIRLSMLRVKKSLFNI 1808
TL ++ D +CTSGSGSGLPFLVQRTVARQI L EC+GKG++GEVW+G +QGE VAVKIFSSR+E SW RET +YNTVLLRH+NILG+ ASD+ S + TQLW++ YH LGSL++YL TL T L++ S A+GL HLH I G QGKPAI+HRD+KSKN+LVKKN CCIADLGLAV N + N VGTKRYMAPE+L ++ CF +S K D+Y++ LVLWE+ R +G+++ Y+ PF + V +DPSFE+M KVV RPN+ L + K+M+ECW+Q PS RL+ LR+KK+L I
Sbjct: 177 TLAEMLDHSCTSGSGSGLPFLVQRTVARQITLAECVGKGRYGEVWRGLWQGESVAVKIFSSRDEKSWFRETELYNTVLLRHENILGFIASDMTSRNSSTQLWLITHYHELGSLYDYLQVTTLDSVTCLRIVLSIASGLAHLHVEIFGTQGKPAISHRDLKSKNVLVKKNGQCCIADLGLAVMHSQTTNQLDVGNNPR---VGTKRYMAPEVLDETIQVDCF---------------------------------DSYKRVDIYAFGLVLWEVARRMVSNGIVEEYKPPFYDVVPNDPSFEDMKKVVCVDQQRPNIPNRWFSDPTLTALAKLMKECWYQNPSARLTALRIKKTLTKI 496
BLAST of Receptor protein serine/threonine kinase vs. Ensembl Xenopus
Match: acvr1 (activin A receptor type 1 [Source:NCBI gene;Acc:550111]) HSP 1 Score: 323.939 bits (829), Expect = 4.871e-102 Identity = 181/356 (50.84%), Postives = 230/356 (64.61%), Query Frame = 3
Query: 759 TLEKLRDDTCTSGSGSGLPFLVQRTVARQINLLECIGKGKFGEVWKGQFQGELVAVKIFXXXXXXXXXXXXNIYNTVLLRHDNILGYYASDLISNSGCTQLWMVMQYHPLGSLHEYLSANTLTVSTVLKLAHSAAAGLCHLHTRIMGLQGKPAIAHRDVKSKNILVKKNLTCCIADLGLAVFPESMGXXXXXXXXXXXRIVGTKRYMAPELLE----LACFLXXXXXXXXXXXXXXXXXXXXXXIMNIHGENYMESLKAADVYSYSLVLWEILSRTTFDGVIQPYQLPFGENVQSDPSFEEMFKVVVEQGLRPNLSEN--IKAQLNPVVKIMEECWHQRPSIRLSMLRVKKSLFNI 1808
TL ++ D +CTSGSGSGLPFLVQRTVARQI L EC+GKG++GEVW+G +QGE VAVKIFSSR+E SW RET +YNTVLLRH+NILG+ ASD+ S + TQLW++ YH LGSL++YL TL T L++ S A+GL HLH I G QGKPAI+HRD+KSKN+LVKKN CCIADLGLAV N + N VGTKRYMAPE+L+ + CF +S K D+Y++ LVLWE+ R +G+++ Y+ PF + V +DPSFE+M KVV RPN+ L + K+M+ECW+Q PS RL+ LR+KK+L I
Sbjct: 182 TLAEMLDHSCTSGSGSGLPFLVQRTVARQITLAECVGKGRYGEVWRGLWQGESVAVKIFSSRDEKSWFRETELYNTVLLRHENILGFIASDMTSRNSSTQLWLITHYHELGSLYDYLQVTTLDSVTCLRIVLSIASGLAHLHVEIFGTQGKPAISHRDLKSKNVLVKKNGQCCIADLGLAVMHSQTTNQLDVGNNPR---VGTKRYMAPEVLDETIQVDCF---------------------------------DSYKRVDIYAFGLVLWEVARRMVSNGIVEEYKPPFYDVVPNDPSFEDMKKVVCVDQQRPNIPNRWFSDPTLTALAKLMKECWYQNPSARLTALRIKKTLTKI 501
BLAST of Receptor protein serine/threonine kinase vs. Ensembl Mouse
Match: Tgfbr1 (transforming growth factor, beta receptor I [Source:MGI Symbol;Acc:MGI:98728]) HSP 1 Score: 316.235 bits (809), Expect = 2.184e-100 Identity = 184/351 (52.42%), Postives = 227/351 (64.67%), Query Frame = 3
Query: 753 GVTLEKLRDDTCTSGSGSGLPFLVQRTVARQINLLECIGKGKFGEVWKGQFQGELVAVKIFXXXXXXXXXXXXNIYNTVLLRHDNILGYYASDLISNSGCTQLWMVMQYHPLGSLHEYLSANTLTVSTVLKLAHSAAAGLCHLHTRIMGLQGKPAIAHRDVKSKNILVKKNLTCCIADLGLAVFPESMGXXXXXXXXXXXRIVGTKRYMAPELLELACFLXXXXXXXXXXXXXXXXXXXXXXIMNIHGENYMESLKAADVYSYSLVLWEILSRTTFDGVIQPYQLPFGENVQSDPSFEEMFKVVVEQGLRPNLSENIKA--QLNPVVKIMEECWHQRPSIRLSMLRVKKSL 1799
G TL+ L D TSGSGSGLP LVQRT+AR I L E IGKG+FGEVW+G+++GE VAVKIFSSREE SW RE IY TV+LRH+NILG+ A+D N TQLW+V YH GSL +YL+ T+TV ++KLA S A+GL HLH I+G QGKPAIAHRD+KSKNILVKKN TCCIADLGLAV +S + N VGTKRYMAPE+L+ + + + ES K AD+Y+ LV WEI R + G+ + YQLP+ + V SDPS EEM KVV EQ LRPN+ ++ L + KIM ECW+ + RL+ LR+KK+L
Sbjct: 91 GTTLKDLIYDMTTSGSGSGLPLLVQRTIARTIVLQESIGKGRFGEVWRGKWRGEEVAVKIFSSREERSWFREAEIYQTVMLRHENILGFIAADNKDNGTWTQLWLVSDYHEHGSLFDYLNRYTVTVEGMIKLALSTASGLAHLHMEIVGTQGKPAIAHRDLKSKNILVKKNGTCCIADLGLAVRHDS---ATDTIDIAPNHRVGTKRYMAPEVLDDSINM-----------------------------KHFESFKRADIYAMGLVFWEIARRCSIGGIHEDYQLPYYDLVPSDPSVEEMRKVVCEQKLRPNIPNRWQSCEALRVMAKIMRECWYANGAARLTALRIKKTL 409
BLAST of Receptor protein serine/threonine kinase vs. Ensembl Mouse
Match: Tgfbr1 (transforming growth factor, beta receptor I [Source:MGI Symbol;Acc:MGI:98728]) HSP 1 Score: 315.464 bits (807), Expect = 6.573e-100 Identity = 184/351 (52.42%), Postives = 227/351 (64.67%), Query Frame = 3
Query: 753 GVTLEKLRDDTCTSGSGSGLPFLVQRTVARQINLLECIGKGKFGEVWKGQFQGELVAVKIFXXXXXXXXXXXXNIYNTVLLRHDNILGYYASDLISNSGCTQLWMVMQYHPLGSLHEYLSANTLTVSTVLKLAHSAAAGLCHLHTRIMGLQGKPAIAHRDVKSKNILVKKNLTCCIADLGLAVFPESMGXXXXXXXXXXXRIVGTKRYMAPELLELACFLXXXXXXXXXXXXXXXXXXXXXXIMNIHGENYMESLKAADVYSYSLVLWEILSRTTFDGVIQPYQLPFGENVQSDPSFEEMFKVVVEQGLRPNLSENIKA--QLNPVVKIMEECWHQRPSIRLSMLRVKKSL 1799
G TL+ L D TSGSGSGLP LVQRT+AR I L E IGKG+FGEVW+G+++GE VAVKIFSSREE SW RE IY TV+LRH+NILG+ A+D N TQLW+V YH GSL +YL+ T+TV ++KLA S A+GL HLH I+G QGKPAIAHRD+KSKNILVKKN TCCIADLGLAV +S + N VGTKRYMAPE+L+ + + + ES K AD+Y+ LV WEI R + G+ + YQLP+ + V SDPS EEM KVV EQ LRPN+ ++ L + KIM ECW+ + RL+ LR+KK+L
Sbjct: 105 GTTLKDLIYDMTTSGSGSGLPLLVQRTIARTIVLQESIGKGRFGEVWRGKWRGEEVAVKIFSSREERSWFREAEIYQTVMLRHENILGFIAADNKDNGTWTQLWLVSDYHEHGSLFDYLNRYTVTVEGMIKLALSTASGLAHLHMEIVGTQGKPAIAHRDLKSKNILVKKNGTCCIADLGLAVRHDS---ATDTIDIAPNHRVGTKRYMAPEVLDDSINM-----------------------------KHFESFKRADIYAMGLVFWEIARRCSIGGIHEDYQLPYYDLVPSDPSVEEMRKVVCEQKLRPNIPNRWQSCEALRVMAKIMRECWYANGAARLTALRIKKTL 423
BLAST of Receptor protein serine/threonine kinase vs. Ensembl Mouse
Match: Acvr1 (activin A receptor, type 1 [Source:MGI Symbol;Acc:MGI:87911]) HSP 1 Score: 317.775 bits (813), Expect = 7.032e-100 Identity = 180/356 (50.56%), Postives = 230/356 (64.61%), Query Frame = 3
Query: 759 TLEKLRDDTCTSGSGSGLPFLVQRTVARQINLLECIGKGKFGEVWKGQFQGELVAVKIFXXXXXXXXXXXXNIYNTVLLRHDNILGYYASDLISNSGCTQLWMVMQYHPLGSLHEYLSANTLTVSTVLKLAHSAAAGLCHLHTRIMGLQGKPAIAHRDVKSKNILVKKNLTCCIADLGLAVFPESMGXXXXXXXXXXXRIVGTKRYMAPELL----ELACFLXXXXXXXXXXXXXXXXXXXXXXIMNIHGENYMESLKAADVYSYSLVLWEILSRTTFDGVIQPYQLPFGENVQSDPSFEEMFKVVVEQGLRPNLSEN--IKAQLNPVVKIMEECWHQRPSIRLSMLRVKKSLFNI 1808
TL +L D +CTSGSGSGLPFLVQRTVARQI LLEC+GKG++GEVW+G +QGE VAVKIFSSR+E SW RET +YNTV+LRH+NILG+ ASD+ S TQLW++ YH +GSL++YL TL + L++ S A+GL HLH I G QGK AIAHRD+KSKNILVKKN CCIADLGLAV + + NN VGTKRYMAPE+L ++ CF +S K D++++ LVLWE+ R +G+++ Y+ PF + V +DPSFE+M KVV RPN+ L + K+M+ECW+Q PS RL+ LR+KK+L I
Sbjct: 179 TLAELLDHSCTSGSGSGLPFLVQRTVARQITLLECVGKGRYGEVWRGSWQGENVAVKIFSSRDEKSWFRETELYNTVMLRHENILGFIASDMTSRHSSTQLWLITHYHEMGSLYDYLQLTTLDTVSCLRIVLSIASGLAHLHIEIFGTQGKSAIAHRDLKSKNILVKKNGQCCIADLGLAVM---HSQSTNQLDVGNNPRVGTKRYMAPEVLDETIQVDCF---------------------------------DSYKRVDIWAFGLVLWEVARRMVSNGIVEDYKPPFYDVVPNDPSFEDMRKVVCVDQQRPNIPNRWFSDPTLTSLAKLMKECWYQNPSARLTALRIKKTLTKI 498
BLAST of Receptor protein serine/threonine kinase vs. Ensembl Mouse
Match: Acvr1 (activin A receptor, type 1 [Source:MGI Symbol;Acc:MGI:87911]) HSP 1 Score: 317.775 bits (813), Expect = 7.032e-100 Identity = 180/356 (50.56%), Postives = 230/356 (64.61%), Query Frame = 3
Query: 759 TLEKLRDDTCTSGSGSGLPFLVQRTVARQINLLECIGKGKFGEVWKGQFQGELVAVKIFXXXXXXXXXXXXNIYNTVLLRHDNILGYYASDLISNSGCTQLWMVMQYHPLGSLHEYLSANTLTVSTVLKLAHSAAAGLCHLHTRIMGLQGKPAIAHRDVKSKNILVKKNLTCCIADLGLAVFPESMGXXXXXXXXXXXRIVGTKRYMAPELL----ELACFLXXXXXXXXXXXXXXXXXXXXXXIMNIHGENYMESLKAADVYSYSLVLWEILSRTTFDGVIQPYQLPFGENVQSDPSFEEMFKVVVEQGLRPNLSEN--IKAQLNPVVKIMEECWHQRPSIRLSMLRVKKSLFNI 1808
TL +L D +CTSGSGSGLPFLVQRTVARQI LLEC+GKG++GEVW+G +QGE VAVKIFSSR+E SW RET +YNTV+LRH+NILG+ ASD+ S TQLW++ YH +GSL++YL TL + L++ S A+GL HLH I G QGK AIAHRD+KSKNILVKKN CCIADLGLAV + + NN VGTKRYMAPE+L ++ CF +S K D++++ LVLWE+ R +G+++ Y+ PF + V +DPSFE+M KVV RPN+ L + K+M+ECW+Q PS RL+ LR+KK+L I
Sbjct: 179 TLAELLDHSCTSGSGSGLPFLVQRTVARQITLLECVGKGRYGEVWRGSWQGENVAVKIFSSRDEKSWFRETELYNTVMLRHENILGFIASDMTSRHSSTQLWLITHYHEMGSLYDYLQLTTLDTVSCLRIVLSIASGLAHLHIEIFGTQGKSAIAHRDLKSKNILVKKNGQCCIADLGLAVM---HSQSTNQLDVGNNPRVGTKRYMAPEVLDETIQVDCF---------------------------------DSYKRVDIWAFGLVLWEVARRMVSNGIVEDYKPPFYDVVPNDPSFEDMRKVVCVDQQRPNIPNRWFSDPTLTSLAKLMKECWYQNPSARLTALRIKKTLTKI 498
BLAST of Receptor protein serine/threonine kinase vs. Ensembl Mouse
Match: Acvr1 (activin A receptor, type 1 [Source:MGI Symbol;Acc:MGI:87911]) HSP 1 Score: 317.775 bits (813), Expect = 7.032e-100 Identity = 180/356 (50.56%), Postives = 230/356 (64.61%), Query Frame = 3
Query: 759 TLEKLRDDTCTSGSGSGLPFLVQRTVARQINLLECIGKGKFGEVWKGQFQGELVAVKIFXXXXXXXXXXXXNIYNTVLLRHDNILGYYASDLISNSGCTQLWMVMQYHPLGSLHEYLSANTLTVSTVLKLAHSAAAGLCHLHTRIMGLQGKPAIAHRDVKSKNILVKKNLTCCIADLGLAVFPESMGXXXXXXXXXXXRIVGTKRYMAPELL----ELACFLXXXXXXXXXXXXXXXXXXXXXXIMNIHGENYMESLKAADVYSYSLVLWEILSRTTFDGVIQPYQLPFGENVQSDPSFEEMFKVVVEQGLRPNLSEN--IKAQLNPVVKIMEECWHQRPSIRLSMLRVKKSLFNI 1808
TL +L D +CTSGSGSGLPFLVQRTVARQI LLEC+GKG++GEVW+G +QGE VAVKIFSSR+E SW RET +YNTV+LRH+NILG+ ASD+ S TQLW++ YH +GSL++YL TL + L++ S A+GL HLH I G QGK AIAHRD+KSKNILVKKN CCIADLGLAV + + NN VGTKRYMAPE+L ++ CF +S K D++++ LVLWE+ R +G+++ Y+ PF + V +DPSFE+M KVV RPN+ L + K+M+ECW+Q PS RL+ LR+KK+L I
Sbjct: 179 TLAELLDHSCTSGSGSGLPFLVQRTVARQITLLECVGKGRYGEVWRGSWQGENVAVKIFSSRDEKSWFRETELYNTVMLRHENILGFIASDMTSRHSSTQLWLITHYHEMGSLYDYLQLTTLDTVSCLRIVLSIASGLAHLHIEIFGTQGKSAIAHRDLKSKNILVKKNGQCCIADLGLAVM---HSQSTNQLDVGNNPRVGTKRYMAPEVLDETIQVDCF---------------------------------DSYKRVDIWAFGLVLWEVARRMVSNGIVEDYKPPFYDVVPNDPSFEDMRKVVCVDQQRPNIPNRWFSDPTLTSLAKLMKECWYQNPSARLTALRIKKTLTKI 498
BLAST of Receptor protein serine/threonine kinase vs. UniProt/SwissProt
Match: sp|Q90ZK6|ACVR1_CHICK (Activin receptor type-1 OS=Gallus gallus OX=9031 GN=ACVR1 PE=2 SV=1) HSP 1 Score: 322.783 bits (826), Expect = 6.165e-101 Identity = 180/352 (51.14%), Postives = 232/352 (65.91%), Query Frame = 3
Query: 759 TLEKLRDDTCTSGSGSGLPFLVQRTVARQINLLECIGKGKFGEVWKGQFQGELVAVKIFXXXXXXXXXXXXNIYNTVLLRHDNILGYYASDLISNSGCTQLWMVMQYHPLGSLHEYLSANTLTVSTVLKLAHSAAAGLCHLHTRIMGLQGKPAIAHRDVKSKNILVKKNLTCCIADLGLAVFPESMGXXXXXXXXXXXRIVGTKRYMAPELLELACFLXXXXXXXXXXXXXXXXXXXXXXIMNIHGENYMESLKAADVYSYSLVLWEILSRTTFDGVIQPYQLPFGENVQSDPSFEEMFKVVVEQGLRPNLSEN--IKAQLNPVVKIMEECWHQRPSIRLSMLRVKKSLFNI 1808
TL L D +CTSGSGSGLPFLVQRTVARQI L+EC+GKG++GEVW+GQ+QGE VAVKIFSSR+E SW RET +YNTVLLRH+NILG+ ASD+ S + TQLW++ YH +GSL++YL TL + L++ S A+GL HLH I G QGKPAI+HRD+KSKNILVKKN CCIADLGLAV + + NN VGTKRYMAPE+L+ I + + +S K D++++ LVLWE+ R +G+++ Y+ PF + V +DPSFE+M KVV RPN+ L + K+M+ECW+Q PS RL+ LR+KK+L I
Sbjct: 174 TLADLLDHSCTSGSGSGLPFLVQRTVARQITLVECVGKGRYGEVWRGQWQGENVAVKIFSSRDEKSWFRETELYNTVLLRHENILGFIASDMTSRNSSTQLWLITHYHEMGSLYDYLQLTTLDTVSCLRIVLSIASGLAHLHIEIFGTQGKPAISHRDLKSKNILVKKNGQCCIADLGLAVM---HSQSTNQLDVGNNPRVGTKRYMAPEVLD----------------------------ETIQADCF-DSYKRVDIWAFGLVLWEVARRMVSNGIVEDYKPPFYDLVPNDPSFEDMRKVVCVDQQRPNIPNRWFSDPTLTSLAKLMKECWYQNPSARLTALRIKKTLTKI 493
BLAST of Receptor protein serine/threonine kinase vs. UniProt/SwissProt
Match: sp|Q28041|ACVR1_BOVIN (Activin receptor type-1 OS=Bos taurus OX=9913 GN=ACVR1 PE=2 SV=1) HSP 1 Score: 320.472 bits (820), Expect = 4.619e-100 Identity = 181/356 (50.84%), Postives = 230/356 (64.61%), Query Frame = 3
Query: 759 TLEKLRDDTCTSGSGSGLPFLVQRTVARQINLLECIGKGKFGEVWKGQFQGELVAVKIFXXXXXXXXXXXXNIYNTVLLRHDNILGYYASDLISNSGCTQLWMVMQYHPLGSLHEYLSANTLTVSTVLKLAHSAAAGLCHLHTRIMGLQGKPAIAHRDVKSKNILVKKNLTCCIADLGLAVFPESMGXXXXXXXXXXXRIVGTKRYMAPELLE----LACFLXXXXXXXXXXXXXXXXXXXXXXIMNIHGENYMESLKAADVYSYSLVLWEILSRTTFDGVIQPYQLPFGENVQSDPSFEEMFKVVVEQGLRPNLSEN--IKAQLNPVVKIMEECWHQRPSIRLSMLRVKKSLFNI 1808
TL L D +CTSGSGSGLPFLVQRTVARQI LLEC+GKG++GEVW+G +QGE VAVKIFSSR+E SW RET +YNTV+LRH+NILG+ ASD+ S TQLW++ YH +GSL++YL TL + L++ S A+GL HLH I G QGKPAIAHRD+KSKNILVKKN CCIADLGLAV + + NN VGTKRYMAPE+L+ + CF +S K D++++ LVLWE+ R +G+++ Y+ PF + V +DPSFE+M KVV RPN+ L + K+M+ECW+Q PS RL+ LR+KK+L I
Sbjct: 179 TLADLLDHSCTSGSGSGLPFLVQRTVARQITLLECVGKGRYGEVWRGSWQGENVAVKIFSSRDEKSWFRETELYNTVMLRHENILGFIASDMTSRHSSTQLWLITHYHEMGSLYDYLQLTTLDTVSCLRIVLSIASGLAHLHIEIFGTQGKPAIAHRDLKSKNILVKKNGQCCIADLGLAVM---HSQSTNQLDVGNNPRVGTKRYMAPEVLDETIQVDCF---------------------------------DSYKRVDIWAFGLVLWEVARRMVSNGIVEDYKPPFYDVVPNDPSFEDMRKVVCVDQQRPNIPNRWFSDPTLTSLAKLMKECWYQNPSARLTALRIKKTLTKI 498
BLAST of Receptor protein serine/threonine kinase vs. UniProt/SwissProt
Match: sp|Q04771|ACVR1_HUMAN (Activin receptor type-1 OS=Homo sapiens OX=9606 GN=ACVR1 PE=1 SV=1) HSP 1 Score: 320.087 bits (819), Expect = 5.711e-100 Identity = 181/356 (50.84%), Postives = 230/356 (64.61%), Query Frame = 3
Query: 759 TLEKLRDDTCTSGSGSGLPFLVQRTVARQINLLECIGKGKFGEVWKGQFQGELVAVKIFXXXXXXXXXXXXNIYNTVLLRHDNILGYYASDLISNSGCTQLWMVMQYHPLGSLHEYLSANTLTVSTVLKLAHSAAAGLCHLHTRIMGLQGKPAIAHRDVKSKNILVKKNLTCCIADLGLAVFPESMGXXXXXXXXXXXRIVGTKRYMAPELLE----LACFLXXXXXXXXXXXXXXXXXXXXXXIMNIHGENYMESLKAADVYSYSLVLWEILSRTTFDGVIQPYQLPFGENVQSDPSFEEMFKVVVEQGLRPNLSEN--IKAQLNPVVKIMEECWHQRPSIRLSMLRVKKSLFNI 1808
TL L D +CTSGSGSGLPFLVQRTVARQI LLEC+GKG++GEVW+G +QGE VAVKIFSSR+E SW RET +YNTV+LRH+NILG+ ASD+ S TQLW++ YH +GSL++YL TL + L++ S A+GL HLH I G QGKPAIAHRD+KSKNILVKKN CCIADLGLAV + + NN VGTKRYMAPE+L+ + CF +S K D++++ LVLWE+ R +G+++ Y+ PF + V +DPSFE+M KVV RPN+ L + K+M+ECW+Q PS RL+ LR+KK+L I
Sbjct: 179 TLADLLDHSCTSGSGSGLPFLVQRTVARQITLLECVGKGRYGEVWRGSWQGENVAVKIFSSRDEKSWFRETELYNTVMLRHENILGFIASDMTSRHSSTQLWLITHYHEMGSLYDYLQLTTLDTVSCLRIVLSIASGLAHLHIEIFGTQGKPAIAHRDLKSKNILVKKNGQCCIADLGLAVM---HSQSTNQLDVGNNPRVGTKRYMAPEVLDETIQVDCF---------------------------------DSYKRVDIWAFGLVLWEVARRMVSNGIVEDYKPPFYDVVPNDPSFEDMRKVVCVDQQRPNIPNRWFSDPTLTSLAKLMKECWYQNPSARLTALRIKKTLTKI 498
BLAST of Receptor protein serine/threonine kinase vs. UniProt/SwissProt
Match: sp|P80201|ACVR1_RAT (Activin receptor type-1 OS=Rattus norvegicus OX=10116 GN=Acvr1 PE=2 SV=1) HSP 1 Score: 317.775 bits (813), Expect = 4.331e-99 Identity = 180/356 (50.56%), Postives = 230/356 (64.61%), Query Frame = 3
Query: 759 TLEKLRDDTCTSGSGSGLPFLVQRTVARQINLLECIGKGKFGEVWKGQFQGELVAVKIFXXXXXXXXXXXXNIYNTVLLRHDNILGYYASDLISNSGCTQLWMVMQYHPLGSLHEYLSANTLTVSTVLKLAHSAAAGLCHLHTRIMGLQGKPAIAHRDVKSKNILVKKNLTCCIADLGLAVFPESMGXXXXXXXXXXXRIVGTKRYMAPELL----ELACFLXXXXXXXXXXXXXXXXXXXXXXIMNIHGENYMESLKAADVYSYSLVLWEILSRTTFDGVIQPYQLPFGENVQSDPSFEEMFKVVVEQGLRPNLSEN--IKAQLNPVVKIMEECWHQRPSIRLSMLRVKKSLFNI 1808
TL +L D +CTSGSGSGLPFLVQRTVARQI LLEC+GKG++GEVW+G +QGE VAVKIFSSR+E SW RET +YNTV+LRH+NILG+ ASD+ S TQLW++ YH +GSL++YL TL + L++ S A+GL HLH I G QGK AIAHRD+KSKNILVKKN CCIADLGLAV + + NN VGTKRYMAPE+L ++ CF +S K D++++ LVLWE+ R +G+++ Y+ PF + V +DPSFE+M KVV RPN+ L + K+M+ECW+Q PS RL+ LR+KK+L I
Sbjct: 179 TLAELLDHSCTSGSGSGLPFLVQRTVARQITLLECVGKGRYGEVWRGSWQGENVAVKIFSSRDEKSWFRETELYNTVMLRHENILGFIASDMTSRHSSTQLWLITHYHEMGSLYDYLQLTTLDTVSCLRIVLSIASGLAHLHIEIFGTQGKSAIAHRDLKSKNILVKKNGQCCIADLGLAVM---HSQSTNQLDVGNNPRVGTKRYMAPEVLDETIQVDCF---------------------------------DSYKRVDIWAFGLVLWEVARRMVSNGIVEDYKPPFYDVVPNDPSFEDMRKVVCVDQQRPNIPNRWFSDPTLTSLAKLMKECWYQNPSARLTALRIKKTLTKI 498
BLAST of Receptor protein serine/threonine kinase vs. UniProt/SwissProt
Match: sp|P37172|ACVR1_MOUSE (Activin receptor type-1 OS=Mus musculus OX=10090 GN=Acvr1 PE=2 SV=2) HSP 1 Score: 317.775 bits (813), Expect = 4.919e-99 Identity = 180/356 (50.56%), Postives = 230/356 (64.61%), Query Frame = 3
Query: 759 TLEKLRDDTCTSGSGSGLPFLVQRTVARQINLLECIGKGKFGEVWKGQFQGELVAVKIFXXXXXXXXXXXXNIYNTVLLRHDNILGYYASDLISNSGCTQLWMVMQYHPLGSLHEYLSANTLTVSTVLKLAHSAAAGLCHLHTRIMGLQGKPAIAHRDVKSKNILVKKNLTCCIADLGLAVFPESMGXXXXXXXXXXXRIVGTKRYMAPELL----ELACFLXXXXXXXXXXXXXXXXXXXXXXIMNIHGENYMESLKAADVYSYSLVLWEILSRTTFDGVIQPYQLPFGENVQSDPSFEEMFKVVVEQGLRPNLSEN--IKAQLNPVVKIMEECWHQRPSIRLSMLRVKKSLFNI 1808
TL +L D +CTSGSGSGLPFLVQRTVARQI LLEC+GKG++GEVW+G +QGE VAVKIFSSR+E SW RET +YNTV+LRH+NILG+ ASD+ S TQLW++ YH +GSL++YL TL + L++ S A+GL HLH I G QGK AIAHRD+KSKNILVKKN CCIADLGLAV + + NN VGTKRYMAPE+L ++ CF +S K D++++ LVLWE+ R +G+++ Y+ PF + V +DPSFE+M KVV RPN+ L + K+M+ECW+Q PS RL+ LR+KK+L I
Sbjct: 179 TLAELLDHSCTSGSGSGLPFLVQRTVARQITLLECVGKGRYGEVWRGSWQGENVAVKIFSSRDEKSWFRETELYNTVMLRHENILGFIASDMTSRHSSTQLWLITHYHEMGSLYDYLQLTTLDTVSCLRIVLSIASGLAHLHIEIFGTQGKSAIAHRDLKSKNILVKKNGQCCIADLGLAVM---HSQSTNQLDVGNNPRVGTKRYMAPEVLDETIQVDCF---------------------------------DSYKRVDIWAFGLVLWEVARRMVSNGIVEDYKPPFYDVVPNDPSFEDMRKVVCVDQQRPNIPNRWFSDPTLTSLAKLMKECWYQNPSARLTALRIKKTLTKI 498
BLAST of Receptor protein serine/threonine kinase vs. TrEMBL
Match: A0A060VY66 (Receptor protein serine/threonine kinase OS=Oncorhynchus mykiss OX=8022 GN=GSONMT00069678001 PE=3 SV=1) HSP 1 Score: 330.487 bits (846), Expect = 1.525e-103 Identity = 184/358 (51.40%), Postives = 234/358 (65.36%), Query Frame = 3
Query: 759 TLEKLRDDTCTSGSGSGLPFLVQRTVARQINLLECIGKGKFGEVWKGQFQGELVAVKIFXXXXXXXXXXXXNIYNTVLLRHDNILGYYASDLISNSGCTQLWMVMQYHPLGSLHEYLSANTLTVSTVLKLAHSAAAGLCHLHTRIMGLQGKPAIAHRDVKSKNILVKKNLTCCIADLGLAV--FPESMGXXXXXXXXXXXRIVGTKRYMAPELLE----LACFLXXXXXXXXXXXXXXXXXXXXXXIMNIHGENYMESLKAADVYSYSLVLWEILSRTTFDGVIQPYQLPFGENVQSDPSFEEMFKVVVEQGLRPNLSEN--IKAQLNPVVKIMEECWHQRPSIRLSMLRVKKSLFNI 1808
TL L D +CTSGSGSGLPFLVQRTVARQI L EC+GKG++GEVW+GQ+QGE VAVKIFSSR+E SW RET IYNTVLLRH+NILG+ ASD+ S + TQLW++ +H +GSL++YL +TL ++ L++A S A+GL HLH I G QGKPAIAHRD+KSKNILV KN CCIADLGLAV F ++ + + VGTKRYMAPE+L+ + CF ES K D++++ LVLWEI T +G+++ Y+ PF + V SDPSFE+M KVV RPN+ L + K+M+ECW+Q PS RL+ LR+KK+L I
Sbjct: 26 TLADLLDHSCTSGSGSGLPFLVQRTVARQITLNECVGKGRYGEVWRGQWQGESVAVKIFSSRDEKSWFRETEIYNTVLLRHENILGFIASDMTSRNSSTQLWLITHFHEMGSLYDYLQLSTLDTASCLRMALSIASGLAHLHVEIFGTQGKPAIAHRDLKSKNILVNKNGQCCIADLGLAVMHFQDTNELDVGNNPK-----VGTKRYMAPEVLDDSIQMDCF---------------------------------ESFKRVDIWAFGLVLWEIARSTVSNGIVEDYKPPFHDAVPSDPSFEDMKKVVCVDQQRPNIPNRWFSDPTLTSIAKLMKECWYQNPSARLTALRIKKTLTKI 345
BLAST of Receptor protein serine/threonine kinase vs. TrEMBL
Match: A0A3P8VSG8 (Receptor protein serine/threonine kinase OS=Cynoglossus semilaevis OX=244447 PE=3 SV=1) HSP 1 Score: 333.183 bits (853), Expect = 1.210e-102 Identity = 190/358 (53.07%), Postives = 236/358 (65.92%), Query Frame = 3
Query: 759 TLEKLRDDTCTSGSGSGLPFLVQRTVARQINLLECIGKGKFGEVWKGQFQGELVAVKIFXXXXXXXXXXXXNIYNTVLLRHDNILGYYASDLISNSGCTQLWMVMQYHPLGSLHEYLSANTLTVSTVLKLAHSAAAGLCHLHTRIMGLQGKPAIAHRDVKSKNILVKKNLTCCIADLGLAV--FPESMGXXXXXXXXXXXRIVGTKRYMAPELL----ELACFLXXXXXXXXXXXXXXXXXXXXXXIMNIHGENYMESLKAADVYSYSLVLWEILSRTTFDGVIQPYQLPFGENVQSDPSFEEMFKVVVEQGLRPNLSEN--IKAQLNPVVKIMEECWHQRPSIRLSMLRVKKSLFNI 1808
TL L D +CTSGSGSGLPFLVQRTVARQI L EC+GKG+FGEVW+GQ+QGE VAVKIFSSR+E SW RET IYNTVLLRH+NILG+ ASD+ S + TQLW++ +H +GSL++YL +TL S+ L++A S A+GL HLH I G QGKPAIAHRD+KSKNILVKKN CCIADLGLAV F ++ + NN VGTKRYMAPE+L ++ CF ES K D+++ LVLWEI RT +G+++ Y+ PF + V SDPSFE+M KVV RPN+ L + K+M+ECW+Q PS RL+ LR+KK+L I
Sbjct: 165 TLADLLDHSCTSGSGSGLPFLVQRTVARQITLNECVGKGRFGEVWRGQWQGESVAVKIFSSRDEKSWFRETEIYNTVLLRHENILGFIASDMTSRNSSTQLWLITHFHEMGSLYDYLQLSTLDASSCLRMALSIASGLAHLHVEIFGTQGKPAIAHRDLKSKNILVKKNGQCCIADLGLAVMHFQDT-----NELDVGNNPKVGTKRYMAPEVLDDSIQMDCF---------------------------------ESFKRVDIWALGLVLWEIARRTVSNGIVEDYKPPFHDVVPSDPSFEDMKKVVCVDQQRPNIPNRWFSDPTLTSMAKLMKECWYQNPSARLTALRIKKTLTKI 484
BLAST of Receptor protein serine/threonine kinase vs. TrEMBL
Match: M4A6D2 (Receptor protein serine/threonine kinase OS=Xiphophorus maculatus OX=8083 PE=3 SV=2) HSP 1 Score: 331.643 bits (849), Expect = 3.363e-102 Identity = 185/358 (51.68%), Postives = 236/358 (65.92%), Query Frame = 3
Query: 759 TLEKLRDDTCTSGSGSGLPFLVQRTVARQINLLECIGKGKFGEVWKGQFQGELVAVKIFXXXXXXXXXXXXNIYNTVLLRHDNILGYYASDLISNSGCTQLWMVMQYHPLGSLHEYLSANTLTVSTVLKLAHSAAAGLCHLHTRIMGLQGKPAIAHRDVKSKNILVKKNLTCCIADLGLAV--FPESMGXXXXXXXXXXXRIVGTKRYMAPELL----ELACFLXXXXXXXXXXXXXXXXXXXXXXIMNIHGENYMESLKAADVYSYSLVLWEILSRTTFDGVIQPYQLPFGENVQSDPSFEEMFKVVVEQGLRPNLSEN--IKAQLNPVVKIMEECWHQRPSIRLSMLRVKKSLFNI 1808
TL L D +CTSGSGSGLPFLVQRTVARQI L EC+GKG++GEVW+GQ+QGE VAVKIFSSR+E SW RET IYNTVLLRH+NILG+ ASD+ S + TQLW++ +H +GSL++YL +TL S+ L++A S A+GL HLH I G QGKPAIAHRD+KSKN+LVKKN CCIADLGLAV F ++ + + VGTKRYMAPE+L ++ CF ES K D+++ LVLWE+ RT +G+++ Y+ PF + V SDPSFE+M KVV RPN+ L+ + K+M+ECW+Q PS RL+ LR+KK+L I
Sbjct: 154 TLADLLDHSCTSGSGSGLPFLVQRTVARQITLNECVGKGRYGEVWRGQWQGESVAVKIFSSRDEKSWFRETEIYNTVLLRHENILGFIASDMTSRNSSTQLWLITHFHEMGSLYDYLQLSTLDASSCLRMALSIASGLAHLHVEIFGTQGKPAIAHRDLKSKNVLVKKNGQCCIADLGLAVMHFQDTNELDVGNNPK-----VGTKRYMAPEVLDDSIQMDCF---------------------------------ESFKRVDIWALGLVLWEVARRTVSNGIVEDYKPPFHDVVPSDPSFEDMKKVVCVDQQRPNIPNRWFSDPTLSSLAKLMKECWYQNPSARLTALRIKKTLTKI 473
BLAST of Receptor protein serine/threonine kinase vs. TrEMBL
Match: A0A3B5KQ18 (Receptor protein serine/threonine kinase OS=Xiphophorus couchianus OX=32473 PE=3 SV=1) HSP 1 Score: 331.643 bits (849), Expect = 4.275e-102 Identity = 185/358 (51.68%), Postives = 236/358 (65.92%), Query Frame = 3
Query: 759 TLEKLRDDTCTSGSGSGLPFLVQRTVARQINLLECIGKGKFGEVWKGQFQGELVAVKIFXXXXXXXXXXXXNIYNTVLLRHDNILGYYASDLISNSGCTQLWMVMQYHPLGSLHEYLSANTLTVSTVLKLAHSAAAGLCHLHTRIMGLQGKPAIAHRDVKSKNILVKKNLTCCIADLGLAV--FPESMGXXXXXXXXXXXRIVGTKRYMAPELL----ELACFLXXXXXXXXXXXXXXXXXXXXXXIMNIHGENYMESLKAADVYSYSLVLWEILSRTTFDGVIQPYQLPFGENVQSDPSFEEMFKVVVEQGLRPNLSEN--IKAQLNPVVKIMEECWHQRPSIRLSMLRVKKSLFNI 1808
TL L D +CTSGSGSGLPFLVQRTVARQI L EC+GKG++GEVW+GQ+QGE VAVKIFSSR+E SW RET IYNTVLLRH+NILG+ ASD+ S + TQLW++ +H +GSL++YL +TL S+ L++A S A+GL HLH I G QGKPAIAHRD+KSKN+LVKKN CCIADLGLAV F ++ + + VGTKRYMAPE+L ++ CF ES K D+++ LVLWE+ RT +G+++ Y+ PF + V SDPSFE+M KVV RPN+ L+ + K+M+ECW+Q PS RL+ LR+KK+L I
Sbjct: 162 TLADLLDHSCTSGSGSGLPFLVQRTVARQITLNECVGKGRYGEVWRGQWQGESVAVKIFSSRDEKSWFRETEIYNTVLLRHENILGFIASDMTSRNSSTQLWLITHFHEMGSLYDYLQLSTLDASSCLRMALSIASGLAHLHVEIFGTQGKPAIAHRDLKSKNVLVKKNGQCCIADLGLAVMHFQDTNELDVGNNPK-----VGTKRYMAPEVLDDSIQMDCF---------------------------------ESFKRVDIWALGLVLWEVARRTVSNGIVEDYKPPFHDVVPSDPSFEDMKKVVCVDQQRPNIPNRWFSDPTLSSLAKLMKECWYQNPSARLTALRIKKTLTKI 481
BLAST of Receptor protein serine/threonine kinase vs. TrEMBL
Match: A0A3P9NSJ5 (Receptor protein serine/threonine kinase OS=Poecilia reticulata OX=8081 PE=3 SV=1) HSP 1 Score: 331.257 bits (848), Expect = 5.368e-102 Identity = 185/358 (51.68%), Postives = 236/358 (65.92%), Query Frame = 3
Query: 759 TLEKLRDDTCTSGSGSGLPFLVQRTVARQINLLECIGKGKFGEVWKGQFQGELVAVKIFXXXXXXXXXXXXNIYNTVLLRHDNILGYYASDLISNSGCTQLWMVMQYHPLGSLHEYLSANTLTVSTVLKLAHSAAAGLCHLHTRIMGLQGKPAIAHRDVKSKNILVKKNLTCCIADLGLAV--FPESMGXXXXXXXXXXXRIVGTKRYMAPELL----ELACFLXXXXXXXXXXXXXXXXXXXXXXIMNIHGENYMESLKAADVYSYSLVLWEILSRTTFDGVIQPYQLPFGENVQSDPSFEEMFKVVVEQGLRPNLSEN--IKAQLNPVVKIMEECWHQRPSIRLSMLRVKKSLFNI 1808
TL L D +CTSGSGSGLPFLVQRTVARQI L EC+GKG++GEVW+GQ+QGE VAVKIFSSR+E SW RET IYNTVLLRH+NILG+ ASD+ S + TQLW++ +H +GSL++YL +TL S+ L++A S A+GL HLH I G QGKPAIAHRD+KSKN+LVKKN CCIADLGLAV F ++ + + VGTKRYMAPE+L ++ CF ES K D+++ LVLWE+ RT +G+++ Y+ PF + V SDPSFE+M KVV RPN+ L+ + K+M+ECW+Q PS RL+ LR+KK+L I
Sbjct: 160 TLADLLDHSCTSGSGSGLPFLVQRTVARQITLNECVGKGRYGEVWRGQWQGESVAVKIFSSRDEKSWFRETEIYNTVLLRHENILGFIASDMTSRNSSTQLWLITHFHEMGSLYDYLQLSTLDASSCLRMALSIASGLAHLHVEIFGTQGKPAIAHRDLKSKNVLVKKNGQCCIADLGLAVMHFQDTNELDVGNNPK-----VGTKRYMAPEVLDDSIQMDCF---------------------------------ESFKRVDIWALGLVLWEVARRTVSNGIVEDYKPPFHDVVPSDPSFEDMKKVVCVDQQRPNIPNRWFSDPTLSSLAKLMKECWYQNPSARLTALRIKKTLTKI 479
BLAST of Receptor protein serine/threonine kinase vs. Ensembl Cavefish
Match: ACVR1 (activin receptor type-1 [Source:NCBI gene;Acc:103030586]) HSP 1 Score: 329.717 bits (844), Expect = 8.888e-105 Identity = 187/356 (52.53%), Postives = 234/356 (65.73%), Query Frame = 3
Query: 759 TLEKLRDDTCTSGSGSGLPFLVQRTVARQINLLECIGKGKFGEVWKGQFQGELVAVKIFXXXXXXXXXXXXNIYNTVLLRHDNILGYYASDLISNSGCTQLWMVMQYHPLGSLHEYLSANTLTVSTVLKLAHSAAAGLCHLHTRIMGLQGKPAIAHRDVKSKNILVKKNLTCCIADLGLAVFPESMGXXXXXXXXXXXRIVGTKRYMAPELL----ELACFLXXXXXXXXXXXXXXXXXXXXXXIMNIHGENYMESLKAADVYSYSLVLWEILSRTTFDGVIQPYQLPFGENVQSDPSFEEMFKVVVEQGLRPNLSEN--IKAQLNPVVKIMEECWHQRPSIRLSMLRVKKSLFNI 1808
TL L D +CTSGSGSGLPFLVQRTVARQI L EC+GKG++GEVW+GQ+QGE VAVKIFSSR+E SW RET IYNTVLLRH+NILG+ ASD+ S + TQLW++ YH +GSL++YL +TL + L++A S A+GL HLH I G QGKPAIAHRD+KSKNILV KN CCIADLGLAV + + NN VGTKRYMAPE+L ++ CF ES K D++++ LVLWEI RT +G+++ Y+ PF + V SDPSFE+M KVV RPN+ + L + K+M+ECW+Q PS RL+ LR+KK+L I
Sbjct: 162 TLADLLDHSCTSGSGSGLPFLVQRTVARQITLNECVGKGRYGEVWRGQWQGENVAVKIFSSRDEKSWFRETEIYNTVLLRHENILGFIASDMTSRNSSTQLWLITHYHEMGSLYDYLQLSTLDAPSCLRMALSIASGLAHLHVEIFGTQGKPAIAHRDLKSKNILVNKNGQCCIADLGLAVMHYQ---DTNELDVGNNPKVGTKRYMAPEVLDDSIQVDCF---------------------------------ESYKRVDIWAFGLVLWEIARRTVSNGIVEDYKPPFHDVVPSDPSFEDMKKVVCIDQQRPNIPNRWFSDSTLTSIAKLMKECWYQNPSARLTALRIKKTLTKI 481
BLAST of Receptor protein serine/threonine kinase vs. Ensembl Cavefish
Match: acvr1l (activin A receptor, type 1 like [Source:ZFIN;Acc:ZDB-GENE-990415-9]) HSP 1 Score: 323.553 bits (828), Expect = 9.922e-103 Identity = 187/364 (51.37%), Postives = 241/364 (66.21%), Query Frame = 3
Query: 735 ATDSGRGVTLEKLRDDTCTSGSGSGLPFLVQRTVARQINLLECIGKGKFGEVWKGQFQGELVAVKIFXXXXXXXXXXXXNIYNTVLLRHDNILGYYASDLISNSGCTQLWMVMQYHPLGSLHEYLSANTLTVSTVLKLAHSAAAGLCHLHTRIMGLQGKPAIAHRDVKSKNILVKKNLTCCIADLGLAVFPESMGXXXXXXXXXXXRIVGTKRYMAPELLELA----CFLXXXXXXXXXXXXXXXXXXXXXXIMNIHGENYMESLKAADVYSYSLVLWEILSRTTFDGVIQPYQLPFGENVQSDPSFEEMFKVVVEQGLRPNLSEN--IKAQLNPVVKIMEECWHQRPSIRLSMLRVKKSLFNI 1808
A G G TL L D +CTSGSGSGLPFLVQRTVARQI+L+EC+GKG++GEVW+GQ+QGE VAVKIFSSR+E SW RET IYNTVLLRH+NILG+ ASD+ S + TQLW++ YH GSL++YL + ++ L++A S A+GL HLHT I G +GKPAIAHRD+KSKNILVKK+L CCIADLGLAV + + NN VGTKRYMAPE+L+ + CF ++ K D++++ LVLWEI RT +G+++ Y+ PF + V +DPSFEEM KVV + RP + L+ +VK+M+ECW+Q PS RL+ LR+KK+L I
Sbjct: 132 APSVGDG-TLADLLDHSCTSGSGSGLPFLVQRTVARQISLVECVGKGRYGEVWRGQWQGENVAVKIFSSRDEKSWFRETEIYNTVLLRHENILGFMASDMTSRNSSTQLWLITHYHENGSLYDYLQRVAVDMAHGLQMAASVASGLVHLHTEIFGTEGKPAIAHRDLKSKNILVKKDLRCCIADLGLAV---THSQADNQLNVGNNPKVGTKRYMAPEVLDESIQTDCF---------------------------------DAYKRVDIWAFGLVLWEIARRTYSNGIVEEYKPPFYDLVPNDPSFEEMRKVVCVEQQRPFIPNRWFSDPTLSALVKLMKECWYQNPSARLTALRIKKTLDKI 458
BLAST of Receptor protein serine/threonine kinase vs. Ensembl Cavefish
Match: ACVR1 (activin receptor type-1 [Source:NCBI gene;Acc:103030586]) HSP 1 Score: 330.102 bits (845), Expect = 1.282e-102 Identity = 187/356 (52.53%), Postives = 234/356 (65.73%), Query Frame = 3
Query: 759 TLEKLRDDTCTSGSGSGLPFLVQRTVARQINLLECIGKGKFGEVWKGQFQGELVAVKIFXXXXXXXXXXXXNIYNTVLLRHDNILGYYASDLISNSGCTQLWMVMQYHPLGSLHEYLSANTLTVSTVLKLAHSAAAGLCHLHTRIMGLQGKPAIAHRDVKSKNILVKKNLTCCIADLGLAVFPESMGXXXXXXXXXXXRIVGTKRYMAPELLE----LACFLXXXXXXXXXXXXXXXXXXXXXXIMNIHGENYMESLKAADVYSYSLVLWEILSRTTFDGVIQPYQLPFGENVQSDPSFEEMFKVVVEQGLRPNLSEN--IKAQLNPVVKIMEECWHQRPSIRLSMLRVKKSLFNI 1808
TL L D +CTSGSGSGLPFLVQRTVARQI L EC+GKG++GEVW+GQ+QGE VAVKIFSSR+E SW RET IYNTVLLRH+NILG+ ASD+ S + TQLW++ YH +GSL++YL +TL + L++A S A+GL HLH I G QGKPAIAHRD+KSKNILV KN CCIADLGLAV + + NN VGTKRYMAPE+L+ + CF ES K D++++ LVLWEI RT +G+++ Y+ PF + V SDPSFE+M KVV RPN+ + L + K+M+ECW+Q PS RL+ LR+KK+L I
Sbjct: 349 TLADLLDHSCTSGSGSGLPFLVQRTVARQITLNECVGKGRYGEVWRGQWQGENVAVKIFSSRDEKSWFRETEIYNTVLLRHENILGFIASDMTSRNSSTQLWLITHYHEMGSLYDYLQLSTLDAPSCLRMALSIASGLAHLHVEIFGTQGKPAIAHRDLKSKNILVNKNGQCCIADLGLAVMHYQ---DTNELDVGNNPKVGTKRYMAPEVLDDSIQVDCF---------------------------------ESYKRVDIWAFGLVLWEIARRTVSNGIVEDYKPPFHDVVPSDPSFEDMKKVVCIDQQRPNIPNRWFSDSTLTSIAKLMKECWYQNPSARLTALRIKKTLTKI 668
BLAST of Receptor protein serine/threonine kinase vs. Ensembl Cavefish
Match: acvr1l (activin A receptor, type 1 like [Source:ZFIN;Acc:ZDB-GENE-990415-9]) HSP 1 Score: 323.168 bits (827), Expect = 6.139e-102 Identity = 187/364 (51.37%), Postives = 241/364 (66.21%), Query Frame = 3
Query: 735 ATDSGRGVTLEKLRDDTCTSGSGSGLPFLVQRTVARQINLLECIGKGKFGEVWKGQFQGELVAVKIFXXXXXXXXXXXXNIYNTVLLRHDNILGYYASDLISNSGCTQLWMVMQYHPLGSLHEYLSANTLTVSTVLKLAHSAAAGLCHLHTRIMGLQGKPAIAHRDVKSKNILVKKNLTCCIADLGLAVFPESMGXXXXXXXXXXXRIVGTKRYMAPELLELA----CFLXXXXXXXXXXXXXXXXXXXXXXIMNIHGENYMESLKAADVYSYSLVLWEILSRTTFDGVIQPYQLPFGENVQSDPSFEEMFKVVVEQGLRPNLSEN--IKAQLNPVVKIMEECWHQRPSIRLSMLRVKKSLFNI 1808
A G G TL L D +CTSGSGSGLPFLVQRTVARQI+L+EC+GKG++GEVW+GQ+QGE VAVKIFSSR+E SW RET IYNTVLLRH+NILG+ ASD+ S + TQLW++ YH GSL++YL + ++ L++A S A+GL HLHT I G +GKPAIAHRD+KSKNILVKK+L CCIADLGLAV + + NN VGTKRYMAPE+L+ + CF ++ K D++++ LVLWEI RT +G+++ Y+ PF + V +DPSFEEM KVV + RP + L+ +VK+M+ECW+Q PS RL+ LR+KK+L I
Sbjct: 176 APSVGDG-TLADLLDHSCTSGSGSGLPFLVQRTVARQISLVECVGKGRYGEVWRGQWQGENVAVKIFSSRDEKSWFRETEIYNTVLLRHENILGFMASDMTSRNSSTQLWLITHYHENGSLYDYLQRVAVDMAHGLQMAASVASGLVHLHTEIFGTEGKPAIAHRDLKSKNILVKKDLRCCIADLGLAV---THSQADNQLNVGNNPKVGTKRYMAPEVLDESIQTDCF---------------------------------DAYKRVDIWAFGLVLWEIARRTYSNGIVEEYKPPFYDLVPNDPSFEEMRKVVCVEQQRPFIPNRWFSDPTLSALVKLMKECWYQNPSARLTALRIKKTLDKI 502
BLAST of Receptor protein serine/threonine kinase vs. Ensembl Cavefish
Match: acvrl1 (activin receptor type-1-like [Source:NCBI gene;Acc:103041954]) HSP 1 Score: 317.39 bits (812), Expect = 5.940e-100 Identity = 178/357 (49.86%), Postives = 233/357 (65.27%), Query Frame = 3
Query: 744 SGRGVTLEKLRDDTCTSGSGSGLPFLVQRTVARQINLLECIGKGKFGEVWKGQFQGELVAVKIFXXXXXXXXXXXXNIYNTVLLRHDNILGYYASDLISNSGCTQLWMVMQYHPLGSLHEYLSANTLTVSTVLKLAHSAAAGLCHLHTRIMGLQGKPAIAHRDVKSKNILVKKNLTCCIADLGLAVFPESMGXXXXXXXXXXXRIVGTKRYMAPELLELACFLXXXXXXXXXXXXXXXXXXXXXXIMNIHGENYMESLKAADVYSYSLVLWEILSRTTFDGVIQPYQLPFGENVQSDPSFEEMFKVVVEQGLRPNLSENIKAQ--LNPVVKIMEECWHQRPSIRLSMLRVKKSLFNI 1808
SG T + D+ CTSGSG+GLP+LVQRT+ARQI+L+EC+GKG++GEVW+G + GE VAVKIFSSR+E SW RET IYNTV LRH+NILG+ ASD+ S + TQLW+V +H LGSL+++L +TL L++ S A+GL HLHT I+ QGKPAIAHRD+KS+NILVK+N CCIADLGLAV + + N VGTKRYMAPE+L+ + + + ES K D+++ LVLWEI RT +G+++ Y+LPF + V SDPSFEEM KVV RP L + + L+ + KIM+ECW Q PS RL+ LRV+K+L +
Sbjct: 155 SGGDPTYGDIFDEFCTSGSGTGLPYLVQRTMARQISLVECVGKGRYGEVWRGTWMGESVAVKIFSSRDEQSWFRETEIYNTVQLRHENILGFIASDMTSKNSSTQLWLVTHFHELGSLYDFLQYSTLDPEGCLRMCLSVASGLVHLHTEILSTQGKPAIAHRDLKSRNILVKRNGQCCIADLGLAVIHSQSNDYLDVGTNPR---VGTKRYMAPEVLDESIRV-----------------------------DVFESYKQTDIWALGLVLWEITRRTIVNGIVEEYRLPFFDVVPSDPSFEEMKKVVCVDQYRPCLHNRLHSHPILSTIAKIMKECWFQSPSARLTALRVRKTLAKL 479
BLAST of Receptor protein serine/threonine kinase vs. Ensembl Sea Lamprey
Match: ENSPMAT00000005861.1 (pep scaffold:Pmarinus_7.0:GL476493:320276:325221:1 gene:ENSPMAG00000005274.1 transcript:ENSPMAT00000005861.1 gene_biotype:protein_coding transcript_biotype:protein_coding) HSP 1 Score: 317.775 bits (813), Expect = 4.319e-103 Identity = 181/352 (51.42%), Postives = 228/352 (64.77%), Query Frame = 3
Query: 771 LRDDTCTSGSGSGLPFLVQRTVARQINLLECIGKGKFGEVWKGQFQGELVAVKIFXXXXXXXXXXXXNIYNTVLLRHDNILGYYASDLISNSGCTQLWMVMQYHPLGSLHEYLSANTLTVSTVLKLAHSAAAGLCHLHTRIMGLQGKPAIAHRDVKSKNILVKKNLTCCIADLGLAVFPESMGXXXXXXXXXXXRIVGTKRYMAPEL----LELACFLXXXXXXXXXXXXXXXXXXXXXXIMNIHGENYMESLKAADVYSYSLVLWEILSRTTFDGVIQPYQLPFGENVQSDPSFEEMFKVVVEQGLRPNLSENI--KAQLNPVVKIMEECWHQRPSIRLSMLRVKKSLFNI 1808
L D +CTSGSGSGLPFLVQRTVARQI L+EC+GKG++GEVW+GQ+QGE VAVKIFSSR+E SW RET IYNTVLLRH+NILG+ ASD+ S + TQLW++ YH GSL+++L L S+ L+LA S AAGL HLH I G GKPAIAHRD+KSKNILVK N CCIADLGLAV + + +N VGT R+MAPE+ L+ CF ++ K AD+++ LVLWEI RT +G+ + Y++PF + V SDPSF+EM KVV + RPN+ L + K+M+ECW+Q PS RL+ LR+KK+L I
Sbjct: 2 LLDHSCTSGSGSGLPFLVQRTVARQITLIECVGKGRYGEVWRGQWQGENVAVKIFSSRDEKSWCRETEIYNTVLLRHENILGFIASDMTSRNSSTQLWLITHYHECGSLYDWLQRWPLEASSCLRLALSVAAGLSHLHGEIFGTHGKPAIAHRDLKSKNILVKGNGQCCIADLGLAVMHSQEWSRLDIGQNPR---VGTVRFMAPEVLDETLQTDCF---------------------------------DAYKRADIWALGLVLWEIARRTLSNGIAEEYRVPFHDAVPSDPSFDEMKKVVCVEQQRPNIPNRWFSDPSLTALAKLMKECWYQNPSARLTALRIKKTLAKI 317
BLAST of Receptor protein serine/threonine kinase vs. Ensembl Sea Lamprey
Match: ENSPMAT00000005886.1 (pep scaffold:Pmarinus_7.0:GL476493:320297:325703:1 gene:ENSPMAG00000005274.1 transcript:ENSPMAT00000005886.1 gene_biotype:protein_coding transcript_biotype:protein_coding) HSP 1 Score: 305.834 bits (782), Expect = 1.703e-98 Identity = 178/350 (50.86%), Postives = 224/350 (64.00%), Query Frame = 3
Query: 789 TSGSGSGLPFLVQRTVARQINLLECIGKGKFGEVWKGQFQGELVAVKIFXXXXXXXXXXXXNIYNTVLLRHDNILGYYASDLISNSGCTQLWMVMQYHPLGSLHEYLSANTLTVSTVLKLAHSAAAGLCHLHTRIMGLQGKPAIAHRDVKSKNILVKKNLTCCIADLGLAVFPESMGXXXXXXXXXXXRIVGTKRYMAPEL----LELACFLXXXXXXXXXXXXXXXXXXXXXXIMNIHGENYMESLKAADVYSYSLVLWEILSRTTFD----GVIQPYQLPFGENVQSDPSFEEMFKVVVEQGLRPNLSENI--KAQLNPVVKIMEECWHQRPSIRLSMLRVKKSLFNI 1808
TSGSGSGLPFLVQRTVARQI L+EC+GKG++GEVW+GQ+QGE VAVKIFSSR+E SW RET IYNTVLLRH+NILG+ ASD+ S + TQLW++ YH GSL+++L L S+ L+LA S AAGL HLH I G GKPAIAHRD+KSKNILVK N CCIADLGLAV + + +N VGT R+MAPE+ L+ CF ++ K AD+++ LVLWEI RT + G+ + Y++PF + V SDPSF+EM KVV + RPN+ L + K+M+ECW+Q PS RL+ LR+KK+L I
Sbjct: 1 TSGSGSGLPFLVQRTVARQITLIECVGKGRYGEVWRGQWQGENVAVKIFSSRDEKSWCRETEIYNTVLLRHENILGFIASDMTSRNSSTQLWLITHYHECGSLYDWLQRWPLEASSCLRLALSVAAGLSHLHGEIFGTHGKPAIAHRDLKSKNILVKGNGQCCIADLGLAVMHSQEWSRLDIGQNPR---VGTVRFMAPEVLDETLQTDCF---------------------------------DAYKRADIWALGLVLWEIARRTLSNVLSLGIAEEYRVPFHDAVPSDPSFDEMKKVVCVEQQRPNIPNRWFSDPSLTALAKLMKECWYQNPSARLTALRIKKTLAKI 314
BLAST of Receptor protein serine/threonine kinase vs. Ensembl Sea Lamprey
Match: ENSPMAT00000006012.1 (pep scaffold:Pmarinus_7.0:GL476493:425401:440684:1 gene:ENSPMAG00000005387.1 transcript:ENSPMAT00000006012.1 gene_biotype:protein_coding transcript_biotype:protein_coding) HSP 1 Score: 305.064 bits (780), Expect = 8.121e-96 Identity = 176/351 (50.14%), Postives = 232/351 (66.10%), Query Frame = 3
Query: 753 GVTLEKLRDDTCTSGSGSGLPFLVQRTVARQINLLECIGKGKFGEVWKGQFQGELVAVKIFXXXXXXXXXXXXNIYNTVLLRHDNILGYYASDLISNSGCTQLWMVMQYHPLGSLHEYLSANTLTVSTVLKLAHSAAAGLCHLHTRIMGLQGKPAIAHRDVKSKNILVKKNLTCCIADLGLAVFPESMGXXXXXXXXXXXRIVGTKRYMAPELLELACFLXXXXXXXXXXXXXXXXXXXXXXIMNIHGENYMESLKAADVYSYSLVLWEILSRTTFDGVIQPYQLPFGENVQSDPSFEEMFKVVVEQGLRPNLSENIKA--QLNPVVKIMEECWHQRPSIRLSMLRVKKSL 1799
G ++ L D+T T+GSGSGLP LVQRT+AR I L + IGKG+FGEVW+G+++GE VAVKIFSSREE SW RE IY TV+LRH+NILG+ A+D N TQLW+V YH LGSL +YL+ +L+V ++K + S A+GL HLH I+G QGKPAIAHRD+KSKNILVK+N TCCIADLGLAV +S ++ ++ NN VGTKRYMAPE+L+ +N+ + +S K D+Y++ LVLWEI R G+ + YQLP+ + V DPS ++M +VV EQ LRPN+ ++ L + ++M ECW+ S RL+ LRVKKSL
Sbjct: 178 GTSIRDLYDNT-TTGSGSGLPLLVQRTIARTIMLQDSIGKGRFGEVWRGRWRGEDVAVKIFSSREERSWFREAEIYQTVMLRHENILGFIAADNKDNGTWTQLWLVSDYHELGSLFDYLNRFSLSVEELVKFSLSVASGLAHLHMDIVGTQGKPAIAHRDIKSKNILVKRNRTCCIADLGLAVRHDSTTDSIDIAPNNR---VGTKRYMAPEVLD--------------------------DTINM---KHFDSFKRGDIYAFGLVLWEISRRCVVGGITEDYQLPYHDMVSPDPSVDDMRRVVCEQSLRPNVPNRWQSSESLRVMGRVMRECWYANASARLTALRVKKSL 495
BLAST of Receptor protein serine/threonine kinase vs. Ensembl Sea Lamprey
Match: ENSPMAT00000003828.1 (pep scaffold:Pmarinus_7.0:GL476610:23057:33770:1 gene:ENSPMAG00000003465.1 transcript:ENSPMAT00000003828.1 gene_biotype:protein_coding transcript_biotype:protein_coding) HSP 1 Score: 301.212 bits (770), Expect = 1.727e-94 Identity = 179/351 (51.00%), Postives = 227/351 (64.67%), Query Frame = 3
Query: 753 GVTLEKLRDDTCTSGSGSGLPFLVQRTVARQINLLECIGKGKFGEVWKGQFQGELVAVKIFXXXXXXXXXXXXNIYNTVLLRHDNILGYYASDLISNSGCTQLWMVMQYHPLGSLHEYLSANTLTVSTVLKLAHSAAAGLCHLHTRIMGLQGKPAIAHRDVKSKNILVKKNLTCCIADLGLAVFPESMGXXXXXXXXXXXRIVGTKRYMAPELLELACFLXXXXXXXXXXXXXXXXXXXXXXIMNIHGENYMESLKAADVYSYSLVLWEILSRTTFDGVIQPYQLPFGENVQSDPSFEEMFKVVVEQGLRPNLSENIKA--QLNPVVKIMEECWHQRPSIRLSMLRVKKSL 1799
G +++ L + TSGSGSGLP LVQRT+AR + L E IGKG+FGEVW+G+++GE VAVKIFSSREE SW RE IY TV+LRH+NILG+ A+D N TQLW+V YH GSL +YL+ T+T + ++A S A+GL HLH I+G QGKPAIAHRD+KSKNILVKKN TC IADLGLAV +S + ++ NN VGTKRYMAPE+L+ L + +S K AD+Y+ LV WEI R T GV+ YQLP+ + V SDPS EEM +VV +Q LRP++ + L+ V KIM+ECW+ + RL+ LRVKKSL
Sbjct: 181 GASIKDLLYEMTTSGSGSGLPLLVQRTIARTVALQESIGKGRFGEVWRGKWRGEDVAVKIFSSREERSWFREAEIYQTVMLRHENILGFIAADNKDNGTWTQLWLVSDYHEHGSLFDYLNRYTVTEEGMARMALSIASGLAHLHMEIVGTQGKPAIAHRDLKSKNILVKKNGTCAIADLGLAVRHDSATDTIDIAPNNR---VGTKRYMAPEVLDDTINL-----------------------------KHFDSFKRADMYALGLVYWEIARRCTQGGVLDEYQLPYYDVVPSDPSVEEMRRVVCDQKLRPSIPTRWHSCKMLHIVAKIMQECWYHNAAARLTALRVKKSL 499
BLAST of Receptor protein serine/threonine kinase vs. Ensembl Sea Lamprey
Match: ENSPMAT00000006990.1 (pep scaffold:Pmarinus_7.0:GL476821:19527:36497:1 gene:ENSPMAG00000006293.1 transcript:ENSPMAT00000006990.1 gene_biotype:protein_coding transcript_biotype:protein_coding) HSP 1 Score: 298.13 bits (762), Expect = 1.504e-93 Identity = 186/352 (52.84%), Postives = 233/352 (66.19%), Query Frame = 3
Query: 759 TLEKLRDDTCTSGSGSGLPFLVQRTVARQINLLECIGKGKFGEVWKGQFQGELVAVKIFXXXXXXXXXXXXNIYNTVLLRHDNILGYYASDLISNSGCTQLWMVMQYHPLGSLHEYLSANTLTVSTVLKLAHSAAAGLCHLHTRIMGLQGKPAIAHRDVKSKNILVKKNLTCCIADLGLAVFPESMGXXXXXXXXXXXRIVGTKRYMAPELLELACFLXXXXXXXXXXXXXXXXXXXXXXIMNIHGENYMESLKAADVYSYSLVLWEILSRTTFDGVIQPYQLPFGENVQSDPSFEEMFKVVVEQGLRPNLSEN--IKAQLNPVVKIMEECWHQRPSIRLSMLRVKKSLFNI 1808
TL L D +CTSGSGSGLPFLVQRTVARQI L++C+GKG+FGEVW+G +QGE VAVKIFSSR+E SW RET IYNTV LRH+NILG+ ASD+ S + TQLW+V +H GSL+++L A TL + L+LA SAAAGL HLH I+G QGKP IAHRD+KSKNILVK N CCIADLGLAV M N L +N VGTKRYMAPELL+ + I + + +S K ADV+++ LVLWEI RT +G+ + Y++PF + V DPSF+EM K+V RP + L + ++M+ECW+Q PS RL+ LR+KK+L I
Sbjct: 149 TLADLFDHSCTSGSGSGLPFLVQRTVARQITLVDCVGKGRFGEVWRGHWQGENVAVKIFSSRDEHSWVRETEIYNTVSLRHENILGFIASDMTSRNSSTQLWLVTHFHETGSLYDHLHAATLDAAACLRLALSAAAGLAHLHVEIVGTQGKPGIAHRDIKSKNILVKDNGQCCIADLGLAVMHSQMTNMLDLGQNPR---VGTKRYMAPELLDDS----------------------------IQADCF-DSFKRADVWAFGLVLWEIARRTVNNGIAEEYKVPFHDIVPCDPSFDEMRKLVCVDQQRPTIPNRWFSDPMLAALARVMKECWYQNPSARLTGLRIKKTLAKI 468
BLAST of Receptor protein serine/threonine kinase vs. Ensembl Yeast
Match: TOS3 (Protein kinase; related to and functionally redundant with Elm1p and Sak1p for the phosphorylation and activation of Snf1p; functionally orthologous to LKB1, a mammalian kinase associated with Peutz-Jeghers cancer-susceptibility syndrome; TOS3 has a paralog, SAK1, that arose from the whole genome duplication [Source:SGD;Acc:S000003147]) HSP 1 Score: 57.7658 bits (138), Expect = 4.308e-9 Identity = 53/214 (24.77%), Postives = 98/214 (45.79%), Query Frame = 3
Query: 819 LVQRTVARQINLLECIGKGKFGEV--WKGQFQGELVAVKIFXXXXXXXXXX--------XXNIYNTVLLR--HDNILGYYASDLISNSGCTQLWMVMQYHPLGSLH---------EYLSANTLTVSTVLKLAHSAAAGLCHLHTRIMGLQGKPAIAHRDVKSKNILVKKNLTCCIADLGLAVFPE--SMGXXXXXXXXXXXRIVGTKRYMAPEL 1391
L +R + +L +G G++G+V + G LVA+KI + E+ S N V+ R H+N++ Y +++++ T++++V++Y G + + + + LT K+ +GL +LH++ I HRD+K N+L+ N T I+D G+A+ S + +R +GT + APEL
Sbjct: 41 LTKRQILNNFEILATLGNGQYGKVKLARDLGTGALVAIKILNRFEKRSGYSLQLKVENPRVNQEIEVMKRCHHENVVELY--EILNDPESTKVYLVLEYCSRGPVKWCPENKMEIKAVGPSILTFQQSRKVVLDVVSGLEYLHSQ--------GITHRDIKPSNLLISSNGTVKISDFGVAMSTATGSTNIQSSHEQLLKSRALGTPAFFAPEL 244
BLAST of Receptor protein serine/threonine kinase vs. Ensembl Yeast
Match: SPS1 (Putative protein serine/threonine kinase; localizes to the nucleus and cytoplasm; required for efficient spore packaging, prospore membrane development and closure and localization of enzymes involved in spore wall synthesis; interacts with and required for Ssp1p phosphorylation and turnover; member of the GCKIII subfamily of STE20 kinases; multiply phosphorylated on S/T residues; interacts with 14-3-3 proteins, Bmh1p and Bmh2p; expressed at the end of meiosis [Source:SGD;Acc:S000002931]) HSP 1 Score: 55.4546 bits (132), Expect = 1.792e-8 Identity = 52/185 (28.11%), Postives = 81/185 (43.78%), Query Frame = 3
Query: 861 CIGKGKFGEVWKG--QFQGELVAVKI--FXXXXXXXXXXXXNIYNTVLLRHDNILGYYASDLISNSGCTQLWMVMQYHPLGSLHEYLS---ANTLTVSTVLKLAHSAAAGLCHLHTRIMGLQGKPAIAHRDVKSKNILVKKNLTCCIADLGLAVFPESMGXXXXXXXXXXXRIVGTKRYMAPELL 1394
CIG+G FG+V+K + E+VA+K+ +E I+ L+ I Y A+ L S +W+VM+Y GS + L N L V + H GL +LH + HRD+K+ NIL+ + + D G++ S + VGT +MAPE++
Sbjct: 23 CIGRGNFGDVYKAVDRVTQEIVAIKVVNLEHSDEDIELLAQEIFFLAELKSPLITNYIATMLEDVS----MWIVMEYCGGGSCSDLLKRSYVNGLPEEKVSFIIHEVTLGLKYLHEQ--------RKIHRDIKAANILLNEEGMVKLGDFGVSGHIRS--------TLKRDTFVGTPYWMAPEVV 187
BLAST of Receptor protein serine/threonine kinase vs. Ensembl Yeast
Match: CDC15 (Protein kinase of the Mitotic Exit Network; localized to the spindle pole bodies at late anaphase; promotes mitotic exit by directly switching on the kinase activity of Dbf2p; required for spindle disassembly after meiosis II; relocalizes to the cytoplasm upon DNA replication stress [Source:SGD;Acc:S000000072]) HSP 1 Score: 53.5286 bits (127), Expect = 9.098e-8 Identity = 52/198 (26.26%), Postives = 91/198 (45.96%), Query Frame = 3
Query: 822 VQRTVAR--QINLLECIGKGKFGEVWKG--QFQGELVAVK-IFXXXXXXXXXXXXNIYNTVLLRHDNILGYYASDLISNSGCTQLWMVMQYHPLGSLHEYLSANTLTVSTVLKLAHSAAA--GLCHLHTRIMGLQGKPAIAHRDVKSKNILVKKNLTCCIADLGLAVFPESMGXXXXXXXXXXXRIVGTKRYMAPELL 1394
+QR + Q +L + IG+G +G V+K + ++VA+K + +E I L H+NI+ Y+ I S +L+++++Y GSL +S ++ +S + GL +LH + HRD+K+ NIL+ + T +AD G++ S + GT +MAPE+L
Sbjct: 15 IQRASEKSVQYHLKQVIGRGSYGVVYKAINKHTDQVVAIKEVVYENDEELNDIMAEISLLKNLNHNNIVKYHG--FIRKS--YELYILLEYCANGSLRRLISRSSTGLSENESKTYVTQTLLGLKYLHGE--------GVIHRDIKAANILLSADNTVKLADFGVSTIVNSSALT----------LAGTLNWMAPEIL 190
BLAST of Receptor protein serine/threonine kinase vs. Ensembl Yeast
Match: KIC1 (Protein kinase of the PAK/Ste20 family, required for cell integrity; physically interacts with Cdc31p (centrin), which is a component of the spindle pole body; part of the RAM network that regulates cellular polarity and morphogenesis [Source:SGD;Acc:S000001144]) HSP 1 Score: 50.447 bits (119), Expect = 8.783e-7 Identity = 47/184 (25.54%), Postives = 77/184 (41.85%), Query Frame = 3
Query: 858 ECIGKGKFGEVWKGQ--FQGELVAVKIFXXXXXXXXXXXXN---IYNTVLLRHDNILGYYASDLISNSGCTQLWMVMQYHPLGSLHEYLSANTLTVSTVLKLAHSAAAGLCHLHTRIMGLQGKPAIAHRDVKSKNILVKKNLTCCIADLGLAVFPESMGXXXXXXXXXXXRIVGTKRYMAPELL 1394
E IG+GKFG V+KG G + A+K+ + +S + + L + NI YY S L T LW++M++ GSL L + + + L +H K + HRD+K+ N+L+ + D G+A + + GT +MAPE++
Sbjct: 27 EVIGRGKFGVVYKGYNVKTGRVYAIKVLNLDSDSDEVEDVQREIQFLASLKQISNITRYYGSYLKD----TSLWIIMEHCAGGSLRSLLRPGKIDEKYIGVIMRELLVALKCIH--------KDNVIHRDIKAANVLITNEGNVKLCDFGVAA-------QVNQTSLRRQTMAGTPYWMAPEVI 191
BLAST of Receptor protein serine/threonine kinase vs. Ensembl Yeast
Match: STE20 (Cdc42p-activated signal transducing kinase; involved in pheromone response, pseudohyphal/invasive growth, vacuole inheritance, down-regulation of sterol uptake; GBB motif binds Ste4p; member of the PAK (p21-activated kinase) family [Source:SGD;Acc:S000000999]) HSP 1 Score: 49.6766 bits (117), Expect = 1.531e-6 Identity = 48/181 (26.52%), Postives = 79/181 (43.65%), Query Frame = 3
Query: 864 IGKGKFGEVWKGQFQGELVAVKIFXXXXXXXXXXXXNIYNTVLL----RHDNILGYYASDLISNSGCTQLWMVMQYHPLGSLHEYLSANTLTVSTVLKLAHSAAAGLCHLHTRIMGLQGKPAIAHRDVKSKNILVKKNLTCCIADLGLAVFPESMGXXXXXXXXXXXRIVGTKRYMAPELL 1394
IG+G G V+ G V+V I E +E I N +L+ +H NI+ + S ++ LW++M+Y GSL + ++ LT + + +GL LH++ + HRD+KS NIL+ + D G + +VGT +MAPE++
Sbjct: 626 IGQGASGGVYTAYEIGTNVSVAIKQMNLEKQPKKEL-IINEILVMKGSKHPNIVNFIDSYVLKG----DLWVIMEYMEGGSLTDVVTHCILTEGQIGAVCRETLSGLEFLHSK--------GVLHRDIKSDNILLSMEGDIKLTDFGFCAQINELNLKRTT-------MVGTPYWMAPEVV 786
BLAST of Receptor protein serine/threonine kinase vs. Ensembl Nematostella
Match: EDO41833 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7S365]) HSP 1 Score: 303.908 bits (777), Expect = 5.087e-95 Identity = 174/359 (48.47%), Postives = 230/359 (64.07%), Query Frame = 3
Query: 753 GVTLEKLRDDTCTSGSGSGLPFLVQRTVARQINLLECIGKGKFGEVWKGQFQGELVAVKIFXXXXXXXXXXXXNIYNTVLLRHDNILGYYASDLISNSGCTQLWMVMQYHPLGSLHEYLSANTLTVSTVLKLAHSAAAGLCHLHTRIMGLQGKPAIAHRDVKSKNILVKKNLTCCIADLGLAV--FPESMGXXXXXXXXXXXRIVGTKRYMAPELLELACFLXXXXXXXXXXXXXXXXXXXXXXIMNIHGENYMESLKAADVYSYSLVLWEILSRTTFD--GVIQPYQLPFGENVQSDPSFEEMFKVVVEQGLRPNLSEN--IKAQLNPVVKIMEECWHQRPSIRLSMLRVKKSLFNIV 1811
G TL+ D + S SGSGLP LVQRT+A+Q+ L++ +GKG++GEVWK ++ GE VAVKIF S E SW RET IY TVLLRH++ILG+ ASD+I + TQ++++M YHPLGSL+++L + L KLA SAAAG+ HLH I+G QGKP IAHRD+KSKNILVK+NLTCCIAD GLAV PE+ G + N VGTKRYM+PE+L I E++ + K AD+YS++LVLWEI R D G+ + Y++P+ + V +DP+FEEM +VVV + RPN+ L + K+M ECW Q+P+ RL+ LRVKKSL +V
Sbjct: 181 GETLKDYFDQS--SASGSGLPLLVQRTIAKQVTLVQSVGKGRYGEVWKARWHGEDVAVKIFLSHCEKSWMRETEIYQTVLLRHESILGFIASDIIGSGQVTQMYLIMDYHPLGSLYDFLRGHQLNKKITGKLAFSAAAGIAHLHAEILGTQGKPMIAHRDIKSKNILVKENLTCCIADFGLAVKYIPETKGIDLNKDTNR----VGTKRYMSPEVLS----------------------------QTIDPESF-SAYKMADMYSFALVLWEISRRCISDETGLCEEYEVPYFDAVSNDPTFEEMKRVVVLERRRPNIPNRWFRDEMLRTMGKLMAECWSQQPAARLTALRVKKSLSKLV 504
BLAST of Receptor protein serine/threonine kinase vs. Ensembl Nematostella
Match: EDO49083 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7RI35]) HSP 1 Score: 297.36 bits (760), Expect = 4.028e-92 Identity = 168/346 (48.55%), Postives = 217/346 (62.72%), Query Frame = 3
Query: 789 TSGSGSGLPFLVQRTVARQINLLECIGKGKFGEVWKGQFQGELVAVKIFXXXXXXXXXXXXNIYNTVLLRHDNILGYYASDLISNSGCTQLWMVMQYHPLGSLHEYLSANTLTVSTVLKLAHSAAAGLCHLHTRIMGLQ---GKPAIAHRDVKSKNILVKKNLTCCIADLGLAVFPESMGXXXXXXXXXXXRIVGTKRYMAPELLELACFLXXXXXXXXXXXXXXXXXXXXXXIMNIHGENYMESLKAADVYSYSLVLWEILSRTTFDGVIQPYQLPFGENVQSDPSFEEMFKVVVEQGLRPNLSENIKAQ--LNPVVKIMEECWHQRPSIRLSMLRVKKSLFNIV 1811
+SGSGSGLP LVQRTVAR+ L+E IGKG++GEVWKG +QGE VA+KIFS+ +E+SW RET IYNTV+LRHDNILG+ A+D+ S T +W++M YH GSL+++L+ +T T+ +LA SAA+GL HLHT I G KPAIAHRD+KSKNILVK N TC + DLGLAV S + N VGT+RYMAPE+LE + S K ADVY++ LVLWEI R G+++ YQ PF + VQSDPS +EM KVVV + RP+L L + K++ ECW+ P+ RL+ LR+KKSL ++
Sbjct: 198 SSGSGSGLPLLVQRTVARETQLIESIGKGRYGEVWKGVYQGESVAIKIFSTTDEASWKRETEIYNTVMLRHDNILGFIAADVHSRKSTTYMWLIMHYHEQGSLYDFLNRSTFDAETLCRLALSAASGLAHLHTEIFGTNRTGSKPAIAHRDIKSKNILVKSNYTCAVGDLGLAVM-YSQDKDSVDMGENPKIAVGTRRYMAPEILEETI-----------------------------NAKCINSFKRADVYAFGLVLWEIARRYVSGGIVEEYQPPFYDMVQSDPSIDEMKKVVVTENKRPSLPNRWTGDPTLQVMSKLIRECWNPNPAARLTSLRIKKSLLKLM 513
BLAST of Receptor protein serine/threonine kinase vs. Ensembl Nematostella
Match: EDO30434 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7T0S6]) HSP 1 Score: 278.1 bits (710), Expect = 1.397e-85 Identity = 163/342 (47.66%), Postives = 213/342 (62.28%), Query Frame = 3
Query: 789 TSGSGSGLPFLVQRTVARQINLLECIGKGKFGEVWKGQFQGELVAVKIFXXXXXXXXXXXXNIYNTVLLRHDNILGYYASDLISNSGCTQLWMVMQYHPLGSLHEYLSANTLTVSTVLKLAHSAAAGLCHLHTRIMGLQGKPAIAHRDVKSKNILVKKNLTCCIADLGLAVFPESMGXXXXXXXXXXXRIVGTKRYMAPELLELACFLXXXXXXXXXXXXXXXXXXXXXXIMNIHGENYMESLKAADVYSYSLVLWEILSRTTFDGVIQPYQLPFGENVQSDPSFEEMFKVVVEQGLRPN-----LSENIKAQLNPVVKIMEECWHQRPSIRLSMLRVKKSL 1799
++GSGSGLP LVQRTVARQI +E IG G++G+V++GQ++GE VAVKIFSSREE SW RE IY TV+LRH+NILG+ A+D N TQLW++ YH GSL++YL TL + ++LKL S A+GL HLH I+G QGKPAIAHRD+KS+NILVK N TCCIADLGLAV S + + VGT+RYMAPE LE ++ + N + K D+Y++ LVLWEI R + YQLP+ + + DPS EE++KVV + RP+ L + + + V K+M+ECWH P RL LR+KK+L
Sbjct: 163 STGSGSGLPLLVQRTVARQITPIELIGSGRYGDVYRGQWRGEDVAVKIFSSREECSWFREAQIYQTVMLRHENILGFIAADNKDNGAWTQLWLITDYHANGSLYDYLQRVTLDMKSMLKLTISIASGLAHLHMEIIGTQGKPAIAHRDLKSRNILVKDNGTCCIADLGLAVCHNS---EQDTLDIPYGNRVGTRRYMAPEFLE-----------------------DSNQVRNFC------AYKHGDIYAFGLVLWEITRRCICSDKCEDYQLPYFDKICVDPSIEEVWKVVCLEKYRPSHPNYWLQDQVMMR---VAKLMQECWHHSPEARLPALRIKKTL 469
BLAST of Receptor protein serine/threonine kinase vs. Ensembl Nematostella
Match: EDO49370 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7RG69]) HSP 1 Score: 183.341 bits (464), Expect = 1.154e-50 Identity = 122/344 (35.47%), Postives = 183/344 (53.20%), Query Frame = 3
Query: 822 VQRTVARQINLLECIGKGKFG-EVWKGQFQGELVAVKIFXXXXXXXXXXXXNIYNTVLLRHDNILGYYASDLISNSGC-----TQLWMVMQYHPLGSLHEYLSANTLTVSTVLKLAHSAAAGLCHLHTRIMGLQG---KPAIAHRDVKSKNILVKKNLTCCIADLGLAV-FPESMGXXXXXXXXXXXRIVGTKRYMAPELLELACFLXXXXXXXXXXXXXXXXXXXXXXIMNIHGENYMESLKAADVYSYSLVLWEILSR-TTFDGVIQPYQLPFGENVQSDPSFEEMFKVVVEQGLRPNLSENIK--AQLNPVVKIMEECWHQRPSIRLSMLRVKKSLFNIVM 1814
+Q R I LLE + +G+FG VWK ++ VAVKIF +E ++W E + Y L H+N+L + ++ S T+ W++ +H GSL ++L +L ++ +L+LA S GL +LH+ + + KP IAHRDVKSKNILVK +LTCCI+D GLA+ F +S E + VGTKRYMAPE+LE A + ES D+Y+ LVLWE+LSR + D ++ Y+LPF + V PS E+M +VVV++ +RP ++ + A L +++ +EECW Q RL+ V + L + +
Sbjct: 136 LQDVNRRPIQLLEVVSQGQFGVTVWKAKYSINTVAVKIFPHQEFTAWVNERDFYKLCGLDHENVLTFIGDEVHHESQYNGQIYTEYWLITDFHENGSLSDFLKQRSLDLAELLQLASSVCDGLAYLHSDVPAINNSSHKPCIAHRDVKSKNILVKSDLTCCISDFGLALKFDQSDKLGETHGQ------VGTKRYMAPEVLEGAISFT------------------------------RESFLRIDMYACGLVLWELLSRFSVHDDPVEDYRLPFEQEVGLHPSLEDMQQVVVQKKMRPQFKDSWRCHAALRVIIQTIEECWDQDGEARLTSHCVAQRLKQVAI 443
BLAST of Receptor protein serine/threonine kinase vs. Ensembl Nematostella
Match: EDO41379 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7S4E9]) HSP 1 Score: 142.51 bits (358), Expect = 5.337e-37 Identity = 100/327 (30.58%), Postives = 159/327 (48.62%), Query Frame = 3
Query: 843 QINLLECIGKGKFGEVWKGQFQGELVAVKIFXXXXXXXXXXXXNIYNTVLLRHDNILGYYASDLISNSGCTQLWMVMQYHPLGSLHEYLSANTLTVSTVLKLAHSAAAGLCHLHTRIMGLQGKPAIAHRDVKSKNILVKKNLTCCIADLGLAVFPESMGXXXXXXXXXXXRIVGTKRYMAPELLELACFLXXXXXXXXXXXXXXXXXXXXXXIMNIHGENYMESLKAADVYSYSLVLWEILSR--TTFDGVIQPYQLPFGENVQSDPSFEEMFKVVVEQGLRPNLSENIK---AQLNPVVKIMEECWHQRPSIRLSMLRVKKSLFNI 1808
Q+ L + IG+G++G VWKG E++AVK+F + W E +++ + L H +IL ++A+ + + ++ +YHP GSL YL +++ + + S +AGL LH KP+ AHRD+ SKNILVK + +C +AD G A+ VGT RYMAPE+L+ A +N+H + +LK DVY+ SLV+WE+ R F + PY+ PF + + E M VV++ LRP + K + L + + +E+CW Q RL L +K + ++
Sbjct: 96 QLTLGQLIGQGRYGTVWKGTMFNEVMAVKVFGAEHRLFWQAEKDLF-SALDHHPSILRFFAACERETNSSPEYLLLSEYHPRGSLQNYLRQHSVCWREMCIMGSSMSAGLAFLHQD----ANKPSFAHRDINSKNILVKVDGSCVLADFGFAMNVSDATKPADDGTLITE--VGTLRYMAPEVLDGA--------------------------VNLH--DIQGALKQIDVYAMSLVIWEVSMRCEDIFGKQVPPYKAPFEAELGPMITSEHMHTYVVQKKLRPGFPDAWKRNHSGLRFLKETIEDCWDQDGDARLLALCIKDRMSDL 387
BLAST of Receptor protein serine/threonine kinase vs. Ensembl Medaka
Match: ENSORLT00000020918.2 (activin A receptor type 1 [Source:NCBI gene;Acc:101173900]) HSP 1 Score: 327.405 bits (838), Expect = 1.077e-103 Identity = 184/354 (51.98%), Postives = 234/354 (66.10%), Query Frame = 3
Query: 759 TLEKLRDDTCTSGSGSGLPFLVQRTVARQINLLECIGKGKFGEVWKGQFQGELVAVKIFXXXXXXXXXXXXNIYNTVLLRHDNILGYYASDLISNSGCTQLWMVMQYHPLGSLHEYLSANTLTVSTVLKLAHSAAAGLCHLHTRIMGLQGKPAIAHRDVKSKNILVKKNLTCCIADLGLAV--FPESMGXXXXXXXXXXXRIVGTKRYMAPELLELACFLXXXXXXXXXXXXXXXXXXXXXXIMNIHGENYMESLKAADVYSYSLVLWEILSRTTFDGVIQPYQLPFGENVQSDPSFEEMFKVVVEQGLRPNLSENIKAQ--LNPVVKIMEECWHQRPSIRLSMLRVKKSLFNI 1808
TL L D +CTSGSGSGLPFLVQRTVARQI L EC+GKG++GEVW+GQ+QGE VAVKIFSSR+E SW RET IYNTVLLRH+NILG+ ASD+ S + TQLW++ +H +GSL++YL +TL L++A S A+GL HLH I G QGKPAIAHRD+KSKNILVKKN CCIADLGLAV F ++ + + VGTKRYMAPE+L+ + + + ES K D+++ LVLWEI RT +G+++ Y+ PF + V SDPSFE+M KVV RPN+ + L + K+M+ECW+Q PS RL+ LR+KK+L I
Sbjct: 171 TLADLLDHSCTSGSGSGLPFLVQRTVARQITLNECVGKGRYGEVWRGQWQGESVAVKIFSSRDEKSWFRETEIYNTVLLRHENILGFIASDMTSRNSSTQLWLITHFHEMGSLYDYLQLSTLDAPGCLRMALSIASGLAHLHVEIFGTQGKPAIAHRDLKSKNILVKKNGQCCIADLGLAVMHFQDTNELDVGNNPK-----VGTKRYMAPEVLDDSIQM-----------------------------DSFESYKRVDIWALGLVLWEIARRTVSNGIVEDYKPPFHDVVPSDPSFEDMKKVVCVDQQRPNIPNRWFSDLTLTSMAKLMKECWYQNPSARLTALRIKKTLTKI 490
BLAST of Receptor protein serine/threonine kinase vs. Ensembl Medaka
Match: ENSORLT00000020917.2 (activin A receptor type 1 [Source:NCBI gene;Acc:101173900]) HSP 1 Score: 325.479 bits (833), Expect = 7.798e-101 Identity = 187/354 (52.82%), Postives = 236/354 (66.67%), Query Frame = 3
Query: 759 TLEKLRDDTCTSGSGSGLPFLVQRTVARQINLLECIGKGKFGEVWKGQFQGELVAVKIFXXXXXXXXXXXXNIYNTVLLRHDNILGYYASDLISNSGCTQLWMVMQYHPLGSLHEYLSANTLTVSTVLKLAHSAAAGLCHLHTRIMGLQGKPAIAHRDVKSKNILVKKNLTCCIADLGLAV--FPESMGXXXXXXXXXXXRIVGTKRYMAPELLELACFLXXXXXXXXXXXXXXXXXXXXXXIMNIHGENYMESLKAADVYSYSLVLWEILSRTTFDGVIQPYQLPFGENVQSDPSFEEMFKVVVEQGLRPNLSEN--IKAQLNPVVKIMEECWHQRPSIRLSMLRVKKSLFNI 1808
TL L D +CTSGSGSGLPFLVQRTVARQI L EC+GKG++GEVW+GQ+QGE VAVKIFSSR+E SW RET IYNTVLLRH+NILG+ ASD+ S + TQLW++ +H +GSL++YL +TL L++A S A+GL HLH I G QGKPAIAHRD+KSKNILVKKN CCIADLGLAV F ++ + NN VGTKRYMAPE+L+ +I +++ ES K D+++ LVLWEI RT +G+++ Y+ PF + V SDPSFE+M KVV RPN+ L + K+M+ECW+Q PS RL+ LR+KK+L I
Sbjct: 351 TLADLLDHSCTSGSGSGLPFLVQRTVARQITLNECVGKGRYGEVWRGQWQGESVAVKIFSSRDEKSWFRETEIYNTVLLRHENILGFIASDMTSRNSSTQLWLITHFHEMGSLYDYLQLSTLDAPGCLRMALSIASGLAHLHVEIFGTQGKPAIAHRDLKSKNILVKKNGQCCIADLGLAVMHFQDT-----NELDVGNNPKVGTKRYMAPEVLD----------------------------DSIQMDSF-ESYKRVDIWALGLVLWEIARRTVSNGIVEDYKPPFHDVVPSDPSFEDMKKVVCVDQQRPNIPNRWFSDLTLTSMAKLMKECWYQNPSARLTALRIKKTLTKI 670
BLAST of Receptor protein serine/threonine kinase vs. Ensembl Medaka
Match: bmpr1aa (bone morphogenetic protein receptor type-1A [Source:NCBI gene;Acc:101169384]) HSP 1 Score: 313.153 bits (801), Expect = 5.288e-98 Identity = 171/343 (49.85%), Postives = 231/343 (67.35%), Query Frame = 3
Query: 789 TSGSGSGLPFLVQRTVARQINLLECIGKGKFGEVWKGQFQGELVAVKIFXXXXXXXXXXXXNIYNTVLLRHDNILGYYASDLISNSGCTQLWMVMQYHPLGSLHEYLSANTLTVSTVLKLAHSAAAGLCHLHTRIMGLQGKPAIAHRDVKSKNILVKKNLTCCIADLGLAVFPESMGXXXXXXXXXXXRIVGTKRYMAPELLELACFLXXXXXXXXXXXXXXXXXXXXXXIMNIHGENYMESLKAADVYSYSLVLWEILSRTTFDGVIQPYQLPFGENVQSDPSFEEMFKVVVEQGLRPNLSE--NIKAQLNPVVKIMEECWHQRPSIRLSMLRVKKSLFNIV 1811
+SGSGSGLP LVQRT+A+QI ++ IGKG++GEVW G+++GE VAVK+F +REE+SW RET IY TVL+RH+NILG+ A+D+ + TQL+++ YH GSL +YL + TL T+L+LA+SAA GLCHLHT I G QGKPAIAHRD+KSKNILVKKN TCCIADLGLAV ++ + + VGT+RYMAPE+L+ + MN +N+ ++ AD+YSY LV+WE+ R G+++ YQLP+ + V SDPS+E+M +VV +GLRP S N L ++K+M ECW P+ RL++LRVKK+L +V
Sbjct: 205 SSGSGSGLPLLVQRTIAKQIQMVRQIGKGRYGEVWLGRWRGEKVAVKVFFTREEASWFRETEIYQTVLMRHENILGFIAADIKGSGAFTQLFLITDYHESGSLFDYLKSTTLDTQTLLRLAYSAACGLCHLHTEIYGTQGKPAIAHRDLKSKNILVKKNGTCCIADLGLAV---KFNSDTNEVDVPLSTRVGTRRYMAPEVLDES--------------------------MN---KNHFQAYVMADIYSYGLVVWEMARRCVTGGIVEDYQLPYYDTVPSDPSYEDMLEVVCVKGLRPTASNRWNSDECLRAMLKLMSECWAHNPTSRLTILRVKKTLAKMV 515
BLAST of Receptor protein serine/threonine kinase vs. Ensembl Medaka
Match: bmpr1aa (bone morphogenetic protein receptor type-1A [Source:NCBI gene;Acc:101169384]) HSP 1 Score: 312.768 bits (800), Expect = 7.088e-98 Identity = 171/343 (49.85%), Postives = 231/343 (67.35%), Query Frame = 3
Query: 789 TSGSGSGLPFLVQRTVARQINLLECIGKGKFGEVWKGQFQGELVAVKIFXXXXXXXXXXXXNIYNTVLLRHDNILGYYASDLISNSGCTQLWMVMQYHPLGSLHEYLSANTLTVSTVLKLAHSAAAGLCHLHTRIMGLQGKPAIAHRDVKSKNILVKKNLTCCIADLGLAVFPESMGXXXXXXXXXXXRIVGTKRYMAPELLELACFLXXXXXXXXXXXXXXXXXXXXXXIMNIHGENYMESLKAADVYSYSLVLWEILSRTTFDGVIQPYQLPFGENVQSDPSFEEMFKVVVEQGLRPNLSE--NIKAQLNPVVKIMEECWHQRPSIRLSMLRVKKSLFNIV 1811
+SGSGSGLP LVQRT+A+QI ++ IGKG++GEVW G+++GE VAVK+F +REE+SW RET IY TVL+RH+NILG+ A+D+ + TQL+++ YH GSL +YL + TL T+L+LA+SAA GLCHLHT I G QGKPAIAHRD+KSKNILVKKN TCCIADLGLAV ++ + + VGT+RYMAPE+L+ + MN +N+ ++ AD+YSY LV+WE+ R G+++ YQLP+ + V SDPS+E+M +VV +GLRP S N L ++K+M ECW P+ RL++LRVKK+L +V
Sbjct: 206 SSGSGSGLPLLVQRTIAKQIQMVRQIGKGRYGEVWLGRWRGEKVAVKVFFTREEASWFRETEIYQTVLMRHENILGFIAADIKGSGAFTQLFLITDYHESGSLFDYLKSTTLDTQTLLRLAYSAACGLCHLHTEIYGTQGKPAIAHRDLKSKNILVKKNGTCCIADLGLAV---KFNSDTNEVDVPLSTRVGTRRYMAPEVLDES--------------------------MN---KNHFQAYVMADIYSYGLVVWEMARRCVTGGIVEDYQLPYYDTVPSDPSYEDMLEVVCVKGLRPTASNRWNSDECLRAMLKLMSECWAHNPTSRLTILRVKKTLAKMV 516
BLAST of Receptor protein serine/threonine kinase vs. Ensembl Medaka
Match: acvr1l (activin receptor type-1 [Source:NCBI gene;Acc:101166428]) HSP 1 Score: 311.997 bits (798), Expect = 9.524e-98 Identity = 180/356 (50.56%), Postives = 233/356 (65.45%), Query Frame = 3
Query: 759 TLEKLRDDTCTSGSGSGLPFLVQRTVARQINLLECIGKGKFGEVWKGQFQGELVAVKIFXXXXXXXXXXXXNIYNTVLLRHDNILGYYASDLISNSGCTQLWMVMQYHPLGSLHEYLSANTLTVSTVLKLAHSAAAGLCHLHTRIMGLQGKPAIAHRDVKSKNILVKKNLTCCIADLGLAVFPESMGXXXXXXXXXXXRIVGTKRYMAPELLELA----CFLXXXXXXXXXXXXXXXXXXXXXXIMNIHGENYMESLKAADVYSYSLVLWEILSRTTFDGVIQPYQLPFGENVQSDPSFEEMFKVVVEQGLRPNLSEN--IKAQLNPVVKIMEECWHQRPSIRLSMLRVKKSLFNI 1808
TL L D +CTSGSGSGLPFLVQRTVARQ +LLEC+GKG++GEVW+GQ+QGE VAVKIFSSR+E SW RET IY+TVLLRH+NIL + ASD+ S + TQLW++ YH GSL++YL + S L +A S A GL HLHT I+G +GK AIAHRD+KSKNILV K L CCIADLGLAV + + L + +N VGTKRYMAPE+L+ + CF ++ K D++++ LVLWEI RT +G+++ Y+ PF + V +DPSFE+M KVV + RP + L+ +VK+M+ECW+Q PS RL+ LR+KK+L I
Sbjct: 178 TLADLLDQSCTSGSGSGLPFLVQRTVARQTSLLECVGKGRYGEVWRGQWQGENVAVKIFSSRDEKSWFRETEIYSTVLLRHENILEFMASDMTSRNSSTQLWLITHYHENGSLYDYLQRVAVETSEGLAMAASVACGLVHLHTEIIGTEGKAAIAHRDLKSKNILVTKELRCCIADLGLAV---THTQADNLLDVGSNPKVGTKRYMAPEVLDDSIQTDCF---------------------------------DAYKRVDIWAFGLVLWEIARRTYSNGIVEEYKPPFYDQVPNDPSFEDMKKVVCVEQQRPFIPNRWFSDPTLSALVKLMKECWYQNPSARLTALRIKKTLDKI 497
BLAST of Receptor protein serine/threonine kinase vs. Planmine SMEST
Match: SMESG000068827.1 (SMESG000068827.1) HSP 1 Score: 1146.34 bits (2964), Expect = 0.000e+0 Identity = 614/616 (99.68%), Postives = 615/616 (99.84%), Query Frame = 3
Query: 78 MQNDTVIHCRCKPKSECFRYSSKGNTCATNEGCFKSVNTKKGELTMGCFKNKTHHYLMHCKVKTWTDMEIKCCQDRDFCNDHLYLPSENLLNTTQSMSDSIFSRSNTDLRWVIAIVLPICLVIIMAGLITMFWNSLWNHKRKLHLKLEYQSKYYPDSSLLAIKTPLFSFPCNTNIFNSTNHRNNINWPIETFTGTGLPXXXXXXXXXXXXXXTATTVISATDSGRGVTLEKLRDDTCTSGSGSGLPFLVQRTVARQINLLECIGKGKFGEVWKGQFQGELVAVKIFXXXXXXXXXXXXNIYNTVLLRHDNILGYYASDLISNSGCTQLWMVMQYHPLGSLHEYLSANTLTVSTVLKLAHSAAAGLCHLHTRIMGLQGKPAIAHRDVKSKNILVKKNLTCCIADLGLAVFPESMGXXXXXXXXXXXRIVGTKRYMAPELLELACFLXXXXXXXXXXXXXXXXXXXXXXIMNIHGENYMESLKAADVYSYSLVLWEILSRTTFDGVIQPYQLPFGENVQSDPSFEEMFKVVVEQGLRPNLSENIKAQLNPVVKIMEECWHQRPSIRLSMLRVKKSLFNIVMKYSNLSENPNETLRSNVSSDLVTSHSDFSQLCNSSRS 1925
MQNDTVIHCRCKPKSECFRYSSKGNTCATNEGCFKSVNTKKGELTMGCFKNKTHHYLMHCKVKTWTDMEIKCCQDRDFCNDHLYLPSENL+NTTQSMSDSIFSRSNTDLRWVIAIVLPICLVIIMAGLITMFWNSLWNHKRKLHLKLEYQSKYYPDSSLLAIKTPLFSFPCNTNIFNSTNHRNNINWPIETFTGTGLPGSKNSSGVGVKSNGTATTVISATDSGRGVTLEKLRDDTCTSGSGSGLPFLVQRTVARQINLLECIGKGKFGEVWKGQFQGELVAVKIFSSREESSWTRETNIYNTVLLRHDNILGYYASDLISNSGCTQLWMVMQYHPLGSLHEYLSANTLTVSTVLKLAHSAAAGLCHLHTRIMGLQGKPAIAHRDVKSKNILVKKNLTCCIADLGLAVFPESMGNNEQLSENNNNRIVGTKRYMAPELLELACFLSNNQSENFNSNNIHLN SSTSSIMNIHGENYMESLKAADVYSYSLVLWEILSRTTFDGVIQPYQLPFGENVQSDPSFEEMFKVVVEQGLRPNLSENIKAQLNPVVKIMEECWHQRPSIRLSMLRVKKSLFNIVMKYSNLSENPNETLRSNVSSDLVTSHSDFSQLCNSSRS
Sbjct: 1 MQNDTVIHCRCKPKSECFRYSSKGNTCATNEGCFKSVNTKKGELTMGCFKNKTHHYLMHCKVKTWTDMEIKCCQDRDFCNDHLYLPSENLVNTTQSMSDSIFSRSNTDLRWVIAIVLPICLVIIMAGLITMFWNSLWNHKRKLHLKLEYQSKYYPDSSLLAIKTPLFSFPCNTNIFNSTNHRNNINWPIETFTGTGLPGSKNSSGVGVKSNGTATTVISATDSGRGVTLEKLRDDTCTSGSGSGLPFLVQRTVARQINLLECIGKGKFGEVWKGQFQGELVAVKIFSSREESSWTRETNIYNTVLLRHDNILGYYASDLISNSGCTQLWMVMQYHPLGSLHEYLSANTLTVSTVLKLAHSAAAGLCHLHTRIMGLQGKPAIAHRDVKSKNILVKKNLTCCIADLGLAVFPESMGNNEQLSENNNNRIVGTKRYMAPELLELACFLSNNQSENFNSNNIHLNISSTSSIMNIHGENYMESLKAADVYSYSLVLWEILSRTTFDGVIQPYQLPFGENVQSDPSFEEMFKVVVEQGLRPNLSENIKAQLNPVVKIMEECWHQRPSIRLSMLRVKKSLFNIVMKYSNLSENPNETLRSNVSSDLVTSHSDFSQLCNSSRS 616
BLAST of Receptor protein serine/threonine kinase vs. Planmine SMEST
Match: SMESG000019732.1 (SMESG000019732.1) HSP 1 Score: 305.834 bits (782), Expect = 5.137e-95 Identity = 214/579 (36.96%), Postives = 308/579 (53.20%), Query Frame = 3
Query: 96 IHCRCKPKSECFRYSSKGNTCATNEGCFKSVN---TKKGELTMGCFKNKTHHYLMHCKVKTWTDMEIKCCQDRDFCNDHLYLPSENLLNTTQSMSDSIFSRSNTDLRWVIAIVLPICLVIIMAGLITMFWNSLWNHKRKLHLKLEY-----QSKYYPDSSLLAIKTPLFSFPCNTNIFNSTNHRNNINWPIETFTGTGLPXXXXXXXXXXXXXXTATTVISATDSGRGVTLEKLRDDTCTSGSGSGLPFLVQRTVARQINLLECIGKGKFGEVWKGQFQGELVAVKIFXXXXXXXXXXXXNIYNTVLLRHDNILGYYASDLISNSGCTQLWMVMQYHPLGSLHEYLSANTLTVSTVLKLAHSAAAGLCHLHTRIM-GLQGKPAIAHRDVKSKNILVKKNLTCCIADLGLAVFPESMGXXXXXXXXXXXRIVGTKRYMAPELLELACFLXXXXXXXXXXXXXXXXXXXXXXIMNIHGENYMESLKAADVYSYSLVLWEILSRTTFDG--VIQPYQLPFGENVQSDPSFEEMFKVVVEQGLRPNLSENIKAQLNPVVKIMEECWHQRPSIRLSMLRVKKSL 1799
I C C + CF C T GCFK ++ G++ + C K H + + T +KCC D + CN + N + S F N I V+P C+ ++ +I + + ++H +LKL ++ Y S + ++ C ++ NS NH + E ++G LP + + R L D+CTSGSGSG+PFLVQRT+ARQ+ L+ IGKG+FGEVWKG + GE+VAVKIFSSR+E+SW RET+IYNT LLRH NILGYYASD++S GCTQLW++ YH LGSL++YL + ++ + + L HS AAGL HLHT I+ G QGKP+IAHRD+KSKNIL+ K CIADLGL+V S N+ ++I GT+RYMAPE+L C + N + S + + E +AD+Y+++LV+WE+L+RT G I Y++P+ + V DPS EM ++V RP L ++ + + ++ E W ++ R S LR+KK+L
Sbjct: 3 ISCICN-YAHCFE-----KKCKTYFGCFKLISLYGNDTGKIYLDCLKESIHDSYI---CQNSTKSLVKCC-DFNLCNKN-----STFNNNIKPNQISNFDE-NDYYSLSIKFVIPFCVAAMILLVICLIMFNKYHHNLSRYLKLYSNFTISRTNYTRQLSENQTEFKPYADDCERSLSNSNNHSRFV----ENYSGL-LPLN--------------------EEEARYNRQSSLHCDSCTSGSGSGMPFLVQRTIARQVQLINGIGKGRFGEVWKGAYYGEMVAVKIFSSRDETSWARETHIYNTYLLRHPNILGYYASDMVSRFGCTQLWLITHYHALGSLYDYLHSTVISFNECVSLLHSTAAGLSHLHTEIISGPQGKPSIAHRDLKSKNILIIKPGEACIADLGLSVLQSSTNCLCPSPVNSKHKI-GTRRYMAPEILA-DCLCPDTDFTIENCLADPTSPSIATVTQHEACPIRFEHFISADIYAFALVMWEVLTRTFLSGQKTIMEYKVPYQDIVPLDPSTPEMRQLVCVDKFRPELPDSKSVFVLELNAMIRESWSEKSQTRPSALRLKKNL 538
BLAST of Receptor protein serine/threonine kinase vs. Planmine SMEST
Match: SMESG000006023.1 (SMESG000006023.1) HSP 1 Score: 237.269 bits (604), Expect = 3.302e-68 Identity = 176/552 (31.88%), Postives = 269/552 (48.73%), Query Frame = 3
Query: 225 KNKTHHYLMHCKVKTW--------TDMEIKCCQDRDFCNDHLYLPSENLLNTTQSMSDSIFSRSNTDLRWVIAIVLPICLVIIMAGLITMFWNSLWNHKRKLHLKLEYQSKYYPDSSLLAIKTPLFSFPCNTNIFN---STNHRNNINWPIETFTGTGLPXXXXXXXXXXXXXXTATTVISATDSGRGVTLEKLRDDTCTSGSGSGLPFLVQRTVARQINLLECIGKGKFGEVWKGQFQGELVAVKIFXXXXXXXXXXXXNIYNTVLLRHDNILGYYASDLISNSGCTQLWMVMQYHPLGSLHEYLSANTLTVSTVLKLAHSAAAGLCHLHTRIMGLQGKPAIAHRDVKSKNILVKKNLTCCIADLGLAVFPESMGXXXXXXXXXXXRIVGTKRYMAPELLELACFLXXXXXXXXXXXXXXXXXXXXXXIMNIHGENYMESLKAADVYSYSLVLWEILSR---TTFDGVIQPYQLPFGENVQSDPSFEEMFKVVVEQGLRPNLSENIKAQLNP---VVKIMEECWHQRPSIRLSMLRVKKSLFNIVMKYSNL 1829
K+ HY M C + + +E +CC+ ++H P + L + IF R V+ P +++ MA LI + + + +Y SK YP ++ L + C +F+ S R++ N P + + G+ +E +C SGSG G+P + +RT A I+L++ +G+G+FG VW G++ G+ VAVKIFSSR+E SW RE ++Y LRH N+LG+ +D N T+LW+V YH GSL EYL A+ +++ +K+ S GL +LHT I GL GKP IAHRD+KS+NILVK CCI DLGLAV + + VGT+RYMAPE++ I N +E+ K AD+YSYSLV+WEIL R ++ + Y++P+ V +DPS EEM ++ ++ +RP ++ + LNP + K + E W + P+ RL+++R+KK + N + S L
Sbjct: 94 KDGIPHYGMGCDGRNFWLQSTCLNAKVESRCCR-----SNHCNYPDSDDLKHMMDQAGIIFPR-------VVETGNPKIVIVCMALLIGVSVVVIIAIVSFKVARRKYLSKKYPQTTDLPHHSFYHKLLCFNKLFSIVRSFRRRSSCNLPSDRDDNKDY---------------RDNLISPFYRPFNGMKIENSFQLSC-SGSGFGMPVMTRRTAATDISLIQAVGEGRFGTVWLGKWNGDNVAVKIFSSRDEVSWAREKDMYQQNFLRHSNVLGFVTTDRRDNGLATELWLVTDYHENGSLFEYLRAHIISIEQAVKMTRSITNGLAYLHTEINGLDGKPGIAHRDLKSRNILVKSCGECCIGDLGLAV------RLIEDCSTLDLNNVGTRRYMAPEII-------------------LDKIVQPDMIYN----GGLEAFKKADIYSYSLVIWEILRRCECSSLNISASAYEMPYQNLVSNDPSIEEMKSIICDRKIRPPINSSWD-NLNPLKDISKSVRESWFEEPASRLNIMRLKKIMNNAWNEISTL 587
BLAST of Receptor protein serine/threonine kinase vs. Planmine SMEST
Match: SMESG000070956.1 (SMESG000070956.1) HSP 1 Score: 166.777 bits (421), Expect = 9.792e-44 Identity = 114/317 (35.96%), Postives = 169/317 (53.31%), Query Frame = 3
Query: 864 IGKGKFGEVWKG------QFQGELVAVKIFXXXXXXXXXXXXNIYNTVLLR---HDNILGYYASDLISNSGCTQLWMVMQYHPLGSLHEYLSANTLTVSTVLKLAHSAAAGLCHLHTRIMGLQGKPAIAHRDVKSKNILVKKNLTCCIADLGLAVFPESMGXXXXXXXXXXXRIVGTKRYMAPELLELACFLXXXXXXXXXXXXXXXXXXXXXXIMNIHGENYMESLKAADVYSYSLVLWEILSRTTFDGV-IQPYQLPFGENVQSDPSFEEMFKVVVEQGLRPNLSENIKAQLNPVVKI---MEECWHQRPSIRLS 1775
+ +G+FG+VW G + + ++VA+KIFS +E + +L+ H NIL Y+ ++ T+LW+V++Y+PLGSL YL +T+T S +L++ + AAGL HLH+ + IAHRD+KSKNIL+K+N T CIAD GLA+ ++ N+ VGT YMAPE+LE + I+ + Y S D++S SLV WE+LSR F + I+ +Q PF E V +PSFE++ + V + LRP +EN L V+K + ECW + P RLS
Sbjct: 277 LAQGRFGQVWSGIIETRNEHKKQIVAIKIFSDNKEGKKSWRNESTVYSILQNGPHPNILKYFGAERRMKDSITELWLVVEYYPLGSLWNYLKKSTVTWSDLLQICQNIAAGLAHLHSFSKPINS--PIAHRDIKSKNILLKENYTACIADFGLAICHQNTDNSFNNR-------VGTLSYMAPEILEGS----------------------------INFDIY--SFLKIDIFSMSLVFWEVLSRFQFSDLHIKDFQNPFQEIVGENPSFEQLRQCVTIKKLRPAFNENW-INLPDVIKFWKTITECWDEDPDARLS 553
BLAST of Receptor protein serine/threonine kinase vs. Planmine SMEST
Match: SMESG000060769.1 (SMESG000060769.1) HSP 1 Score: 126.716 bits (317), Expect = 1.742e-30 Identity = 109/346 (31.50%), Postives = 163/346 (47.11%), Query Frame = 3
Query: 873 GKFGEVWKGQF-----QGEL--VAVKIFXXXXXXXXXXXXNIYNTVLLRHDNILGYYASD-LISNSGCTQLWMVMQYHPLGSLHEYLSANTLTVST---VLKLAHSAAAGLCHLHTR-----IMGLQGKPAIAHRDVKSKNILVKKNLTCCIADLGLAVFPESMGXXXXXXXXXXXRIVGTKRYMAPELLELACFLXXXXXXXXXXXXXXXXXXXXXXIMNIHGENYMESLKAADVYSYSLVLWEILSR-TTFDGVIQ-------PYQLPFGENVQSDPSFEEMFKVVVEQGLRPNLSENIK--AQLNPVVKIMEECWHQRPSIRLSMLRVKKSLFNIVMKYSNLS 1832
GKFGE+W G+ G + VA+KI R+ESSW E ++Y + R IL Y D +++N+ + W+V QY GSL++ LS + T VL + A GL +LH + GKP+IAHRD+KS+NIL+K + CIADLGLAV + + L VGT+RYMAPE+LE A +N ++++ D+Y+ +L++WE+ S+ T F G+ + Y PF + + + E + VV RP L + + + + ECW + RLS V + L + K SN S
Sbjct: 188 GKFGEIWSGKLISDHSNGAIGNVAIKILRPRDESSWETEIDMYRYIRNRCSRILRYIGCDKIVTNNEIEEFWLVTQYIEYGSLYDCLSDSVRTKPNWFQVLNVCLDIAGGLSYLHEDGSYQTSAHISGKPSIAHRDLKSRNILIKADWKACIADLGLAVSFQGNRSLSDLHLQ-----VGTQRYMAPEVLEGA--------------------------INFSRDSFL----GIDIYAMALIMWEVFSQCTDFQGLAECEASEPSVYMQPFEQELGIHITMESLQSWVVNDNKRPQLPSQYSGFSDGQSLWRTIVECWDRDAEARLSAGCVYERLMTLYQKASNSS 498 The following BLAST results are available for this feature:
BLAST of Receptor protein serine/threonine kinase vs. Ensembl Human
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Human e!99) Total hits: 5
BLAST of Receptor protein serine/threonine kinase vs. Ensembl Celegans
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99) Total hits: 5
BLAST of Receptor protein serine/threonine kinase vs. Ensembl Fly
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99) Total hits: 5
BLAST of Receptor protein serine/threonine kinase vs. Ensembl Zebrafish
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99) Total hits: 5
BLAST of Receptor protein serine/threonine kinase vs. Ensembl Xenopus
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99) Total hits: 5
BLAST of Receptor protein serine/threonine kinase vs. Ensembl Mouse
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99) Total hits: 5
BLAST of Receptor protein serine/threonine kinase vs. UniProt/SwissProt
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt) Total hits: 5
BLAST of Receptor protein serine/threonine kinase vs. TrEMBL
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL) Total hits: 5
BLAST of Receptor protein serine/threonine kinase vs. Ensembl Cavefish
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99) Total hits: 5
BLAST of Receptor protein serine/threonine kinase vs. Ensembl Sea Lamprey
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99) Total hits: 5
BLAST of Receptor protein serine/threonine kinase vs. Ensembl Yeast
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46) Total hits: 5
BLAST of Receptor protein serine/threonine kinase vs. Ensembl Nematostella
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46) Total hits: 5
BLAST of Receptor protein serine/threonine kinase vs. Ensembl Medaka
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99) Total hits: 5
BLAST of Receptor protein serine/threonine kinase vs. Planmine SMEST
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST) Total hits: 5
Analyses
This transcript is derived from or has results from the following analyses Sequences
The following sequences are available for this feature:
transcript sequence >SMED30010098 ID=SMED30010098|Name=Receptor protein serine/threonine kinase|organism=Schmidtea mediterranea sexual|type=transcript|length=2171bpback to top protein sequence of SMED30010098-orf-1 >SMED30010098-orf-1 ID=SMED30010098-orf-1|Name=SMED30010098-orf-1|organism=Schmidtea mediterranea sexual|type=polypeptide|length=617bp MQNDTVIHCRCKPKSECFRYSSKGNTCATNEGCFKSVNTKKGELTMGCFKback to top Annotated Terms
The following terms have been associated with this transcript:
InterPro
Analysis Name: Schmidtea mediteranean smed_20140614 Interproscan
Date Performed: 2020-05-01
|
