TPA_inf: prohormone convertase 2

Query:  475 IVTNQWHVHLHDPATQESANKVAQETGFSVLRNHLNSPNEFVFHHKTVPHVSSVPSWSQHKVLLAHHLVKNAKQVEGFLRRKRGYKPIKKQGRVPLPTINKKGIPGLGESDNIKVDLKLPTDPLFSKEWYIRNTGQADGVKDLDLNVLSAWAQGITGKGVTTAIMDDGIDYLHPDLSKNYNAESSYDFSSNDPYPFPRYTDDWFNSHGTRCAGEISAERDNGICGVGVAYDSKIAGLRMLDQPYMTDLIEAAAMSYDRDNIDIYSASWGPTDDGRTVDGPRNETMRAIVEGVNKGRKGKGSIYVWASXXXXXXXXXXXXXXXXSMWTISINSATNDGETASYDESCSSTLASTFSNGKAWFSLDAGVGTVDLYGQCTLHHSGTSAAAPEAAGVFALALEANSNIGWRDMQHLTVLTSKXXXXXXXXXXXXWTINGAGLEFNHLFGYGVLDAGDMVRVAKKWVNVPERFHCIAGQIDKRYRFNVTKALILEIDTDACKSDIGHRVNYLEHVQAFVSVKSSRRGDITMFLTSPMGTTSMILSHRPKDDDSTRGFTKWPFMTTHTWGENPRGKWKLTVMFDTKDPLSQGIFSEWVLVLHGTQSRPY 2283
            + TN + V LH    ++ A +VA E GF V R    +   + F+H  +       S    + L     VK A Q EGF R+KRGY+ I +                        +D+ +  DPLF+K+WY+ NTGQADG   LDLNV  AW  G TGKGVT  IMDDGIDYLHPDL+ NYNAE+SYDFSSNDPYP+PRYTDDWFNSHGTRCAGE+SA  +N ICGVGVAY+SK+AG+RMLDQP+MTD+IEA+++S+    IDIYSASWGPTD+G+TVDGPR  T++A+ +GVNKGR GKGSIYVWASGDGG+ DDCNCDGYA+SMWTISINSA NDG TA YDESCSSTLASTFSNG+   + +AGV T DLYG CTL HSGTSAAAPEAAGVFALALEAN  + WRDMQHLTVLTSK       D  H W  NG GLEFNHLFGYGVLDAG MV++AK W  VPERFHC+ G +    +   T  L+L + TDAC+    + V YLEHVQA ++V ++RRGD+ + +TSPMGT S++LS RP+DDDS  GF KWPFMTTHTWGE+ RG W L + F    P  +G+  EW L+LHGTQS PY
Sbjct:   10 VFTNHFLVELH-KGGEDKARQVAAEHGFGV-RKLPFAEGLYHFYHNGLAKAKRRRSLHHKQQLERDPRVKMALQQEGFDRKKRGYRDINE------------------------IDINM-NDPLFTKQWYLINTGQADGTPGLDLNVAEAWELGYTGKGVTIGIMDDGIDYLHPDLASNYNAEASYDFSSNDPYPYPRYTDDWFNSHGTRCAGEVSAAANNNICGVGVAYNSKVAGIRMLDQPFMTDIIEASSISHMPQLIDIYSASWGPTDNGKTVDGPRELTLQAMADGVNKGRGGKGSIYVWASGDGGSYDDCNCDGYASSMWTISINSAINDGRTALYDESCSSTLASTFSNGRK-RNPEAGVATTDLYGNCTLRHSGTSAAAPEAAGVFALALEANLGLTWRDMQHLTVLTSK--RNQLHDEVHQWRRNGVGLEFNHLFGYGVLDAGAMVKMAKDWKTVPERFHCVGGSVQDPEKIPSTGKLVLTLTTDACEGK-ENFVRYLEHVQAVITVNATRRGDLNINMTSPMGTKSILLSRRPRDDDSKVGFDKWPFMTTHTWGEDARGTWTLELGFVGSAP-QKGVLKEWTLMLHGTQSAPY 580          

Query:  475 IVTNQWHVHLHDPATQESANKVAQETGFSVLRNHLNSPNEFVFHHKTVPHVSSVPSWSQHKVLLAHHLVKNAKQVEGFLRRKRGYKPIKKQGRVPLPTINKKGIPGLGESDNIKVDLKLPTDPLFSKEWYIRNTGQADGVKDLDLNVLSAWAQGITGKGVTTAIMDDGIDYLHPDLSKNYNAESSYDFSSNDPYPFPRYTDDWFNSHGTRCAGEISAERDNGICGVGVAYDSKIAGLRMLDQPYMTDLIEAAAMSYDRDNIDIYSASWGPTDDGRTVDGPRNETMRAIVEGVNKGRKGKGSIYVWASXXXXXXXXXXXXXXXXSMWTISINSATNDGETASYDESCSSTLASTFSNGKAWFSLDAGVGTVDLYGQCTLHHSGTSAAAPEAAGVFALALEANSNIGWRDMQHLTVLTSKXXXXXXXXXXXXWTINGAGLEFNHLFGYGVLDAGDMVRVAKKWVNVPERFHCIAGQIDKRYRFNVTKALILEIDTDACKSDIGHRVNYLEHVQAFVSVKSSRRGDITMFLTSPMGTTSMILSHRPKDDDSTRGFTKWPFMTTHTWGENPRGKWKLTVMFDTKDPLSQGIFSEWVLVLHGTQSRPY 2283
            + TN + V LH    ++ A +VA E GF V R    +   + F+H  +       S    + L     VK A Q EGF R+KRGY+ I +                        +D+ +  DPLF+K+WY+ NTGQADG   LDLNV  AW  G TGKGVT  IMDDGIDYLHPDL+ NYNAE+SYDFSSNDPYP+PRYTDDWFNSHGTRCAGE+SA  +N ICGVGVAY+SK+AG+RMLDQP+MTD+IEA+++S+    IDIYSASWGPTD+G+TVDGPR  T++A+ +GVNKGR GKGSIYVWASGDGG+ DDCNCDGYA+SMWTISINSA NDG TA YDESCSSTLASTFSNG+   + +AGV T DLYG CTL HSGTSAAAPEAAGVFALALEAN  + WRDMQHLTVLTSK       D  H W  NG GLEFNHLFGYGVLDAG MV++AK W  VPERFHC+ G +    +   T  L+L + TDAC+    + V YLEHVQA ++V ++RRGD+ + +TSPMGT S++LS RP+DDDS  GF KWPFMTTHTWGE+ RG W L + F    P  +G+  EW L+LHGTQS PY
Sbjct:   29 VFTNHFLVELH-KGGEDKARQVAAEHGFGV-RKLPFAEGLYHFYHNGLAKAKRRRSLHHKQQLERDPRVKMALQQEGFDRKKRGYRDINE------------------------IDINM-NDPLFTKQWYLINTGQADGTPGLDLNVAEAWELGYTGKGVTIGIMDDGIDYLHPDLASNYNAEASYDFSSNDPYPYPRYTDDWFNSHGTRCAGEVSAAANNNICGVGVAYNSKVAGIRMLDQPFMTDIIEASSISHMPQLIDIYSASWGPTDNGKTVDGPRELTLQAMADGVNKGRGGKGSIYVWASGDGGSYDDCNCDGYASSMWTISINSAINDGRTALYDESCSSTLASTFSNGRK-RNPEAGVATTDLYGNCTLRHSGTSAAAPEAAGVFALALEANLGLTWRDMQHLTVLTSK--RNQLHDEVHQWRRNGVGLEFNHLFGYGVLDAGAMVKMAKDWKTVPERFHCVGGSVQDPEKIPSTGKLVLTLTTDACEGK-ENFVRYLEHVQAVITVNATRRGDLNINMTSPMGTKSILLSRRPRDDDSKVGFDKWPFMTTHTWGEDARGTWTLELGFVGSAP-QKGVLKEWTLMLHGTQSAPY 599          

Query:  475 IVTNQWHVHLHDPATQESANKVAQETGFSVLRNHLNSPNEFVFHHKTVPHVSSVPSWSQHKVLLAHHLVKNAKQVEGFLRRKRGYKPIKKQGRVPLPTINKKGIPGLGESDNIKVDLKLPTDPLFSKEWYIRNTGQADGVKDLDLNVLSAWAQGITGKGVTTAIMDDGIDYLHPDLSKNYNAESSYDFSSNDPYPFPRYTDDWFNSHGTRCAGEISAERDNGICGVGVAYDSKIAGLRMLDQPYMTDLIEAAAMSYDRDNIDIYSASWGPTDDGRTVDGPRNETMRAIVEGVNKGRKGKGSIYVWASXXXXXXXXXXXXXXXXSMWTISINSATNDGETASYDESCSSTLASTFSNGKAWFSLDAGVGTVDLYGQCTLHHSGTSAAAPEAAGVFALALEANSNIGWRDMQHLTVLTSKXXXXXXXXXXXXWTINGAGLEFNHLFGYGVLDAGDMVRVAKKWVNVPERFHCIAGQIDKRYRFNVTKALILEIDTDACKSDIGHRVNYLEHVQAFVSVKSSRRGDITMFLTSPMGTTSMILSHRPKDDDSTRGFTKWPFMTTHTWGENPRGKWKLTVMFDTKDPLSQGIFSEWVLVLHGTQSRPY 2283
            + TN + V LH    ++ A +VA E GF V +                                    VK A Q EGF R+KRGY+ I +                        +D+ +  DPLF+K+WY+ NTGQADG   LDLNV  AW  G TGKGVT  IMDDGIDYLHPDL+ NYNAE+SYDFSSNDPYP+PRYTDDWFNSHGTRCAGE+SA  +N ICGVGVAY+SK+AG+RMLDQP+MTD+IEA+++S+    IDIYSASWGPTD+G+TVDGPR  T++A+ +GVNKGR GKGSIYVWASGDGG+ DDCNCDGYA+SMWTISINSA NDG TA YDESCSSTLASTFSNG+   + +AGV T DLYG CTL HSGTSAAAPEAAGVFALALEAN  + WRDMQHLTVLTSK       D  H W  NG GLEFNHLFGYGVLDAG MV++AK W  VPERFHC+ G +    +   T  L+L + TDAC+    + V YLEHVQA ++V ++RRGD+ + +TSPMGT S++LS RP+DDDS  GF KWPFMTTHTWGE+ RG W L + F    P  +G+  EW L+LHGTQS PY
Sbjct:   29 VFTNHFLVELH-KGGEDKARQVAAEHGFGVRK------------------------------------VKMALQQEGFDRKKRGYRDINE------------------------IDINM-NDPLFTKQWYLINTGQADGTPGLDLNVAEAWELGYTGKGVTIGIMDDGIDYLHPDLASNYNAEASYDFSSNDPYPYPRYTDDWFNSHGTRCAGEVSAAANNNICGVGVAYNSKVAGIRMLDQPFMTDIIEASSISHMPQLIDIYSASWGPTDNGKTVDGPRELTLQAMADGVNKGRGGKGSIYVWASGDGGSYDDCNCDGYASSMWTISINSAINDGRTALYDESCSSTLASTFSNGRK-RNPEAGVATTDLYGNCTLRHSGTSAAAPEAAGVFALALEANLGLTWRDMQHLTVLTSK--RNQLHDEVHQWRRNGVGLEFNHLFGYGVLDAGAMVKMAKDWKTVPERFHCVGGSVQDPEKIPSTGKLVLTLTTDACEGK-ENFVRYLEHVQAVITVNATRRGDLNINMTSPMGTKSILLSRRPRDDDSKVGFDKWPFMTTHTWGEDARGTWTLELGFVGSAP-QKGVLKEWTLMLHGTQSAPY 564          

Query:  421 MKITWILLFLCEYVVCG-----KIVTNQWHVHLHDPATQESANKVAQETGFSVLRNHLNSPNEFVFHHKTVPHVSSVPSWSQHKVLLAHHLVKNAKQVEGFLRRKRGYKPIKKQGRVPLPTINKKGIPGLGESDNIKVDLKLPTDPLFSKEWYIRNTGQADGVKDLDLNVLSAWAQGITGKGVTTAIMDDGIDYLHPDLSKNYNAESSYDFSSNDPYPFPRYTDDWFNSHGTRCAGEISAERDNGICGVGVAYDSKIAGLRMLDQPYMTDLIEAAAMSYDRDNIDIYSASWGPTDDGRTVDGPRNETMRAIVEGVNKGRKGKGSIYVWAS-XXXXXXXXXXXXXXXXSMWTISINSATNDGETASYDESCSSTLASTFSNGKAWFSLDAGVGTVDLYGQCTLHHSGTSAAAPEAAGVFALALEANSNIGWRDMQHLTVLTSKXXXXXXXXXXXXWTINGAGLEFNHLFGYGVLDAGDMVRVA--KKWVNVPERFHCIAGQIDKRYR-FNVTKALILEIDTDACKSDIGHRVNYLEHVQAFVSVKSSRRGDITMFLTSPMGTTSMILSHRPKDDDSTRGFTKWPFMTTHTWGENPRGKWKLTVMFDTKDPLSQGIFSEWVLVLHGTQSRP 2280
            ++ T  +LF C +         +   N+W   +  P   E+A+ +A+E G+ +L    +  N ++F HK  P  S   ++   K L     V  A+Q     R KR                       L +S      L L  DP+++++WY+++T     +  LDL+V+  W +GITGKGV   ++DDG+++ H D+  NY+ E+SYDF+ ND  PFPRY     N HGTRCAGEI+ + +N  CGVGVAY+SK+ G+RMLD   +TD IEA+++ ++  ++DIYSASWGP DDG+TV+GP     +A   GV +GR+GKGSI+VWAS   G   D+C+CDGY  S++TISI+SA+  G +  Y E CSSTLA+++S+G      D  + + DL+  CT  H+GTSA+AP AAG+FALALEAN N+ WRDMQHL V TS+            W  NGAGL  N  FG+G+L+A  +V +A  + W +VPE+  C+    D   R       +I+EI T AC+    + +  LEHVQ   +++ SRRGD+ + LTS  GT++++L+ R + D S  GF  W FM+ HTWGENP G W L +   +    ++G    W L+LHGT S+P
Sbjct:    8 LQCTAFVLF-CAWCALNSAKAKRQFVNEWAAEI--PGGPEAASAIAEELGYDLLGQIGSLENHYLFKHKNHPRRSRRSAFHITKRLSDDDRVIWAEQQYEKERSKRS---------------------ALRDSA-----LNLFNDPMWNQQWYLQDTRMTAALPKLDLHVIPVWQKGITGKGVVITVLDDGLEWNHTDIYANYDPEASYDFNDNDHDPFPRYDPTNENKHGTRCAGEIAMQANNHKCGVGVAYNSKVGGIRMLDG-IVTDAIEASSIGFNPGHVDIYSASWGPNDDGKTVEGPGRLAQKAFEYGVKQGRQGKGSIFVWASGNGGRQGDNCDCDGYTDSIYTISISSASQQGLSPWYAEKCSSTLATSYSSGDY---TDQRITSADLHNDCTETHTGTSASAPLAAGIFALALEANPNLTWRDMQHLVVWTSE---YDPLANNPGWKKNGAGLMVNSRFGFGLLNAKALVDLADPRTWRSVPEKKECVVKDNDFEPRALKANGEVIIEIPTRACEGQ-ENAIKSLEHVQFEATIEYSRRGDLHVTLTSAAGTSTVLLAERER-DTSPNGFKNWDFMSVHTWGENPIGTWTLRITDMSGRIQNEGRIVNWKLILHGTSSQP 598          

Query:  823 LKLPTDPLFSKEWYIRNTGQADGVKDLDLNVLSAWAQGITGKGVTTAIMDDGIDYLHPDLSKNYNAESSYDFSSNDPYPFPRYTDDWFNSHGTRCAGEISAERDNGICGVGVAYDSKIAGLRMLDQPYMTDLIEAAAMSYDRDNIDIYSASWGPTDDGRTVDGPRNETMRAIVEGVNKGRKGKGSIYVWAS-XXXXXXXXXXXXXXXXSMWTISINSATNDGETASYDESCSSTLASTFSNGKAWFSLDAGVGTVDLYGQCTLHHSGTSAAAPEAAGVFALALEANSNIGWRDMQHLTVLTSKXXXXXXXXXXXXWTINGAGLEFNHLFGYGVLDAGDMVRVA--KKWVNVPERFHCIAGQIDKRYR-FNVTKALILEIDTDACKSDIGHRVNYLEHVQAFVSVKSSRRGDITMFLTSPMGTTSMILSHRPKDDDSTRGFTKWPFMTTHTWGENPRGKWKLTVMFDTKDPLSQGIFSEWVLVLHGTQSRP 2280
            L L  DP+++++WY+++T     +  LDL+V+  W +GITGKGV   ++DDG+++ H D+  NY+ E+SYDF+ ND  PFPRY     N HGTRCAGEI+ + +N  CGVGVAY+SK+ G+RMLD   +TD IEA+++ ++  ++DIYSASWGP DDG+TV+GP     +A   GV +GR+GKGSI+VWAS   G   D+C+CDGY  S++TISI+SA+  G +  Y E CSSTLA+++S+G      D  + + DL+  CT  H+GTSA+AP AAG+FALALEAN N+ WRDMQHL V TS+            W  NGAGL  N  FG+G+L+A  +V +A  + W +VPE+  C+    D   R       +I+EI T AC+    + +  LEHVQ   +++ SRRGD+ + LTS  GT++++L+ R + D S  GF  W FM+ HTWGENP G W L +   +    ++G    W L+LHGT S+P
Sbjct:   71 LNLFNDPMWNQQWYLQDTRMTAALPKLDLHVIPVWQKGITGKGVVITVLDDGLEWNHTDIYANYDPEASYDFNDNDHDPFPRYDPTNENKHGTRCAGEIAMQANNHKCGVGVAYNSKVGGIRMLDG-IVTDAIEASSIGFNPGHVDIYSASWGPNDDGKTVEGPGRLAQKAFEYGVKQGRQGKGSIFVWASGNGGRQGDNCDCDGYTDSIYTISISSASQQGLSPWYAEKCSSTLATSYSSGDY---TDQRITSADLHNDCTETHTGTSASAPLAAGIFALALEANPNLTWRDMQHLVVWTSE---YDPLANNPGWKKNGAGLMVNSRFGFGLLNAKALVDLADPRTWRSVPEKKECVVKDNDFEPRALKANGEVIIEIPTRACEGQ-ENAIKSLEHVQFEATIEYSRRGDLHVTLTSAAGTSTVLLAERER-DTSPNGFKNWDFMSVHTWGENPIGTWTLRITDMSGRIQNEGRIVNWKLILHGTSSQP 551          

Query:  427 ITWILLFLCEYVVCGKIV---TNQWHVHLHDPATQESANKVAQETGFSVLRNHLNSPNEFVFHHKTVPHVSSVPSWSQHKVLLAHHLVKNAKQVEGFLRRKRGYKPIKKQGRVPLPTINKKGIPGLGESDNIKVDLKLPTDPLFSKEWYIRNTGQADGVKDLDLNVLSAWAQGITGKGVTTAIMDDGIDYLHPDLSKNYNAESSYDFSSNDPYPFPRYTDDWFNSHGTRCAGEISAERDNGICGVGVAYDSKIAGLRMLDQPYMTDLIEAAAMSYDRDNIDIYSASWGPTDDGRTVDGPRNETMRAIVEGVNKGRKGKGSIYVWASXXXXXXXXXXXXXXXXSMWTISINSATNDGETASYDESCSSTLASTFSNGKAWFSLDAGVGTVDLYGQCTLHHSGTSAAAPEAAGVFALALEANSNIGWRDMQHLTVLTSKXXX--------------------XXXXXXXXXWTINGAGLEFNHLFGYGVLDAGDMVRVAKKWVNVPERFHCIAGQIDKRYRFNVTKALILEIDTDACKSDIGHRVNYLEHVQAFVSVKSSRRGDITMFLTSPMGTTSMILSHRPKDDDSTRGFTKWPFMTTHTWGENPRGKWKLTVMFDTKDPLSQGIFSEWVLVLHGTQSRPYDKLSSSLEKIIPKLGVVKRQH 2346
            +  I +FL  ++  G+ V   TN +HVHL +    E A+++A+  GF        S NE+ F    + H  +  S   H  L     V + +Q++G+ R KRGY+P++++                 ES      +  P+DPL+  +WY++NTGQA G   LDLNV  AWA G TGK +TTAIMDDG+DY+HPD+  N+NAE+SYDFSSNDP+P+PRYTDDWFNSHGTRCAGEI A RDNG+CGVGVAYD K+AG+RMLDQPYMTDLIEA +M ++   I IYSASWGPTDDG+TVDGPRN TMRAIV GVN+GR G GSI+VWASGDGG  DDCNCDGYAASMWTISINSA N+GE A YDESCSSTLASTFSNG    + + GV T DLYG+CT  HSGTSAAAPEAAGVFALALEAN ++ WRD+QHLTVLTS RN                      H       W +NG GLE+NHLFG+GVLDA +MV +A  W   P R+HC AG ID  +       LILEI+TD C       V YLEHVQA VS  S+RRGD T++L SPMGT +MILS RPKDDDS  GFT WPFMTTHTWGENP GKW+L   F      + G   ++ L+LHGT+  PY+ +   + +   KL  V++ H
Sbjct:    6 VDLICVFLSIFIGIGEAVDVYTNHFHVHLKEGGGLEDAHRIAKRHGFINRGQVAASDNEYHFVQPALVHARTRRSAGHHAKLHNDDEVLHVEQLKGYTRTKRGYRPLEQRL----------------ESQFDFSAVMSPSDPLYGYQWYLKNTGQAGGKARLDLNVERAWAMGFTGKNITTAIMDDGVDYMHPDIKNNFNAEASYDFSSNDPFPYPRYTDDWFNSHGTRCAGEIVAARDNGVCGVGVAYDGKVAGIRMLDQPYMTDLIEANSMGHEPSKIHIYSASWGPTDDGKTVDGPRNATMRAIVRGVNEGRNGLGSIFVWASGDGGEDDDCNCDGYAASMWTISINSAINNGENAHYDESCSSTLASTFSNGGR--NPETGVATTDLYGRCTRSHSGTSAAAPEAAGVFALALEANPSLTWRDLQHLTVLTSSRNSLFDGRCRDFPSLGINDNHRDSHGNCSHFEWQMNGVGLEYNHLFGFGVLDAAEMVMLAMAWKTSPPRYHCTAGLIDTPHEIPADGNLILEINTDGCAGS-QFEVRYLEHVQAVVSFNSTRRGDTTLYLISPMGTRTMILSRRPKDDDSKDGFTNWPFMTTHTWGENPTGKWRLVARFQGPGAHA-GTLKKFELMLHGTREAPYNLIEPIVGQTNKKLDTVQKAH 648          

Query:  832 PTDPLFSKEWYIRNTGQADGVKDLDLNVLSAWAQGITGKGVTTAIMDDGIDYLHPDLSKNYNAESSYDFSSNDPYPFPRYTDDWFNSHGTRCAGEISAERDNGICGVGVAYDSKIAGLRMLDQPYMTDLIEAAAMSYDRDNIDIYSASWGPTDDGRTVDGPRNETMRAIVEGVNKGRKGKGSIYVWASXXXXXXXXXXXXXXXXSMWTISINSATNDGETASYDESCSSTLASTFSNGKAWFSLDAGVGTVDLYGQCTLHHSGTSAAAPEAAGVFALALEANSNIGWRDMQHLTVLTSKXXX--------------------XXXXXXXXXWTINGAGLEFNHLFGYGVLDAGDMVRVAKKWVNVPERFHCIAGQIDKRYRFNVTKALILEIDTDACKSDIGHRVNYLEHVQAFVSVKSSRRGDITMFLTSPMGTTSMILSHRPKDDDSTRGFTKWPFMTTHTWGENPRGKWKLTVMFDTKDPLSQ-GIFSEWVLVLHGTQSRPYDKLSSSLEKIIPKLGVVKRQH 2346
            P+DPL+  +WY++NTGQA G   LDLNV  AWA G TGK +TTAIMDDG+DY+HPD+  N+NAE+SYDFSSNDP+P+PRYTDDWFNSHGTRCAGEI A RDNG+CGVGVAYD K+AG+RMLDQPYMTDLIEA +M ++   I IYSASWGPTDDG+TVDGPRN TMRAIV GVN+GR G GSI+VWASGDGG  DDCNCDGYAASMWTISINSA N+GE A YDESCSSTLASTFSNG    + + GV T DLYG+CT  HSGTSAAAPEAAGVFALALEAN ++ WRD+QHLTVLTS RN                      H       W +NG GLE+NHLFG+GVLDA +MV +A  W   P R+HC AG ID  +       LILEI+TD C       V YLEHVQA VS  S+RRGD T++L SPMGT +MILS RPKDDDS  GFT WPFMTTHTWGENP GKW+L   F  + P +  G   ++ L+LHGT+  PY+ +   + +   KL  V++ H
Sbjct:    3 PSDPLYGYQWYLKNTGQAGGKARLDLNVERAWAMGFTGKNITTAIMDDGVDYMHPDIKNNFNAEASYDFSSNDPFPYPRYTDDWFNSHGTRCAGEIVAARDNGVCGVGVAYDGKVAGIRMLDQPYMTDLIEANSMGHEPSKIHIYSASWGPTDDGKTVDGPRNATMRAIVRGVNEGRNGLGSIFVWASGDGGEDDDCNCDGYAASMWTISINSAINNGENAHYDESCSSTLASTFSNGGR--NPETGVATTDLYGRCTRSHSGTSAAAPEAAGVFALALEANPSLTWRDLQHLTVLTSSRNSLFDGRCRDFPSLGINDNHRDSHGNCSHFEWQMNGVGLEYNHLFGFGVLDAAEMVMLAMAWKTSPPRYHCTAGLIDTPHEIPADGNLILEINTDGCAGSQ-FEVRYLEHVQAVVSFNSTRRGDTTLYLISPMGTRTMILSRRPKDDDSKDGFTNWPFMTTHTWGENPTGKWRLVARF--QGPGAHAGTLKKFELMLHGTREAPYNLIEPIVGQTNKKLDTVQKAH 523          

Query:  832 PTDPLFSKEWYIRNTGQADGVKDLDLNVLSAWAQGITGKGVTTAIMDDGIDYLHPDLSKNYNAESSYDFSSNDPYPFPRYTDDWFNSHGTRCAGEISAERDNGICGVGVAYDSKIAGLRMLDQPYMTDLIEAAAMSYDRDNIDIYSASWGPTDDGRTVDGPRNETMRAIVEGVNKGRKGKGSIYVWASXXXXXXXXXXXXXXXXSMWTISINSATNDGETASYDESCSSTLASTFSNGKAWFSLDAGVGTVDLYGQCTLHHSGTSAAAPEAAGVFALALEANSNIGWRDMQHLTVLTSKXXX--------------------XXXXXXXXXWTINGAGLEFNHLFGYGVLDAGDMVRVAKKWVNVPERFHCIAGQIDKRYRFNVTKALILEIDTDACKSDIGHRVNYLEHVQAFVSVKSSRRGDITMFLTSPMGTTSMILSHRPKDDDSTRGFTKWPFMTTHTWGENPRGKWKLTVMFDTKDPLSQ-GIFSEWVLVLHGTQSRPYDKLSSSLEKIIPKLGVVKRQH 2346
            P+DPL+  +WY++NTGQA G   LDLNV  AWA G TGK +TTAIMDDG+DY+HPD+  N+NAE+SYDFSSNDP+P+PRYTDDWFNSHGTRCAGEI A RDNG+CGVGVAYD K+AG+RMLDQPYMTDLIEA +M ++   I IYSASWGPTDDG+TVDGPRN TMRAIV GVN+GR G GSI+VWASGDGG  DDCNCDGYAASMWTISINSA N+GE A YDESCSSTLASTFSNG    + + GV T DLYG+CT  HSGTSAAAPEAAGVFALALEAN ++ WRD+QHLTVLTS RN                      H       W +NG GLE+NHLFG+GVLDA +MV +A  W   P R+HC AG ID  +       LILEI+TD C       V YLEHVQA VS  S+RRGD T++L SPMGT +MILS RPKDDDS  GFT WPFMTTHTWGENP GKW+L   F  + P +  G   ++ L+LHGT+  PY+ +   + +   KL  V++ H
Sbjct:    3 PSDPLYGYQWYLKNTGQAGGKARLDLNVERAWAMGFTGKNITTAIMDDGVDYMHPDIKNNFNAEASYDFSSNDPFPYPRYTDDWFNSHGTRCAGEIVAARDNGVCGVGVAYDGKVAGIRMLDQPYMTDLIEANSMGHEPSKIHIYSASWGPTDDGKTVDGPRNATMRAIVRGVNEGRNGLGSIFVWASGDGGEDDDCNCDGYAASMWTISINSAINNGENAHYDESCSSTLASTFSNGGR--NPETGVATTDLYGRCTRSHSGTSAAAPEAAGVFALALEANPSLTWRDLQHLTVLTSSRNSLFDGRCRDFPSLGINDNHRDSHGNCSHFEWQMNGVGLEYNHLFGFGVLDAAEMVMLAMAWKTSPPRYHCTAGLIDTPHEIPADGNLILEINTDGCAGSQ-FEVRYLEHVQAVVSFNSTRRGDTTLYLISPMGTRTMILSRRPKDDDSKDGFTNWPFMTTHTWGENPTGKWRLVARF--QGPGAHAGTLKKFELMLHGTREAPYNLIEPIVGQTNKKLDTVQKAH 523          

Query:  472 KIVTNQWHVHLHDPATQESANKVAQETGFSVLRNHLNSPNEFVFHHKTVPHVSSVPSWSQHKVLLAHHL-VKNAKQVEGFLRRKRGYKPIKKQGRVPLPTINKKGIPGLGESDNIKVDLKLPTDPLFSKEWYI-RNTGQADGVKDLDLNVLSAWAQGITGKGVTTAIMDDGIDYLHPDLSKNYNAESSYDFSSNDPYPFPRYTDDWFNSHGTRCAGEISAERDNGICGVGVAYDSKIAGLRMLDQPYMTDLIEAAAMSYDRDNIDIYSASWGPTDDGRTVDGPRNETMRAIVEGVNKGRKGKGSIYVWAS-XXXXXXXXXXXXXXXXSMWTISINSATNDGETASYDESCSSTLASTFSNGKAWFSLDAGVGTVDLYGQCTLHHSGTSAAAPEAAGVFALALEANSNIGWRDMQHLTVLTSKXXXXXXXXXXXXWTINGAGLEFNHLFGYGVLDAGDMVRVAKKWVNVPERFHCIAGQIDKRYRFNVTKALILEIDTDACKSDIG-HRVNYLEHVQAFVSVKSSRRGDITMFLTSPMGTTSMILSHRPKDDDSTRGFTKWPFMTTHTWGENPRGKWKLTVMFDTKDPLSQGIFSEWVLVLHGT 2268
            +  TN+W V +     +E AN++A + G++ L   +     ++F        SS  + S     L H   V   +Q     R KRGY+ I++        I ++   G   S +       P DPL++  WY+ R    +D    +D NV  AW  G TGKGV   I+DDG++  HPD+S NY+  +SYD +  D  P PRY     N HGTRCAGE++A  +N +C VG+AY++ I G+RMLD   +TD +EAA++ ++ D IDIYSASWGP DDGRTVDGP   T  A  +G+  GRKGKGSI+VWAS   G  AD CNCDGY  S++T+SI+SAT +G    Y E+CSSTLA+T+S+G     +   + T DL+  CT  H+GTSA+AP AAG+ ALALEAN N+ WRD+QH+ + T+K        R  +WT NG G   +H FGYG++DAG MV++AK W  V E+  C      +         L L++ +D C      ++V+Y+EHVQA V++K+ +RGD+ ++LTSP GT S +L+ R + D S  GFT W FMTTH WGE   G W L +  D  D        +W LVL+GT
Sbjct:   56 RTYTNEWAVRIAGGKVEE-ANRLANKYGYTNLGPIIPGDEYYLFRDDRKKSRSSRKTRSLSANQLQHEEDVMWMEQQVAKRRVKRGYRRIRRH--TDDNDIFEEDDDGTQISKSRNRKHPDPNDPLWTDMWYLNRGEHHSDSTTRMDHNVKEAWDLGYTGKGVVVTILDDGLERTHPDISPNYDERASYDVNDRDNDPMPRYEFSDENRHGTRCAGEVAAIFNNSLCIVGIAYNANIGGIRMLDGD-VTDAVEAASVGHNADYIDIYSASWGPDDDGRTVDGPAKLTRSAFEKGITMGRKGKGSIFVWASGNGGKDADSCNCDGYTNSIYTLSISSATENGNIPWYSEACSSTLATTYSSGATGEKM---ILTTDLHHACTNMHTGTSASAPLAAGIVALALEANPNLTWRDLQHIVIRTAK----PINLRAGDWTTNGVGRNVSHSFGYGLMDAGAMVKLAKIWKKVDEQHRCRQFYPSRYKNIPNGNRLQLQLYSDGCYGGADENKVSYVEHVQAIVTLKAPKRGDLQIYLTSPSGTKSTLLTKRAR-DTSRSGFTDWAFMTTHNWGEQAAGLWILEIDNDGWDDAE---LVKWELVLYGT 643          

Query:  472 KIVTNQWHVHLHDPATQESANKVAQETGFSVLRNHLNSPNEFVFHHKTVPHVSSVPSWSQHKVLLAHHL-VKNAKQVEGFLRRKRGYKPIKKQGRVPLPTINKKGIPGLGESDNIKVDLKLPTDPLFSKEWYI-RNTGQADGVKDLDLNVLSAWAQGITGKGVTTAIMDDGIDYLHPDLSKNYNAESSYDFSSNDPYPFPRYTDDWFNSHGTRCAGEISAERDNGICGVGVAYDSKIAGLRMLDQPYMTDLIEAAAMSYDRDNIDIYSASWGPTDDGRTVDGPRNETMRAIVEGVNKGRKGKGSIYVWAS-XXXXXXXXXXXXXXXXSMWTISINSATNDGETASYDESCSSTLASTFSNGKAWFSLDAGVGTVDLYGQCTLHHSGTSAAAPEAAGVFALALEANSNIGWRDMQHLTVLTSKXXXXXXXXXXXXWTINGAGLEFNHLFGYGVLDAGDMVRVAKKWVNVPERFHCIAGQIDKRYRFNVTKALILEIDTDACKSDIG-HRVNYLEHVQAFVSVKSSRRGDITMFLTSPMGTTSMILSHRPKDDDSTRGFTKWPFMTTHTWGENPRGKWKLTVMFDTKDPLSQGIFSEWVLVLHGT 2268
            +  TN+W V +     +E AN++A + G++ L   +     ++F        SS  + S     L H   V   +Q     R KRGY+ I++        I ++   G   S +       P DPL++  WY+ R    +D    +D NV  AW  G TGKGV   I+DDG++  HPD+S NY+  +SYD +  D  P PRY     N HGTRCAGE++A  +N +C VG+AY++ I G+RMLD   +TD +EAA++ ++ D IDIYSASWGP DDGRTVDGP   T  A  +G+  GRKGKGSI+VWAS   G  AD CNCDGY  S++T+SI+SAT +G    Y E+CSSTLA+T+S+G     +   + T DL+  CT  H+GTSA+AP AAG+ ALALEAN N+ WRD+QH+ + T+K        R  +WT NG G   +H FGYG++DAG MV++AK W  V E+  C      +         L L++ +D C      ++V+Y+EHVQA V++K+ +RGD+ ++LTSP GT S +L+ R + D S  GFT W FMTTH WGE   G W L +  D  D        +W LVL+GT
Sbjct:   56 RTYTNEWAVRIAGGKVEE-ANRLANKYGYTNLGPIIPGDEYYLFRDDRKKSRSSRKTRSLSANQLQHEEDVMWMEQQVAKRRVKRGYRRIRRH--TDDNDIFEEDDDGTQISKSRNRKHPDPNDPLWTDMWYLNRGEHHSDSTTRMDHNVKEAWDLGYTGKGVVVTILDDGLERTHPDISPNYDERASYDVNDRDNDPMPRYEFSDENRHGTRCAGEVAAIFNNSLCIVGIAYNANIGGIRMLDGD-VTDAVEAASVGHNADYIDIYSASWGPDDDGRTVDGPAKLTRSAFEKGITMGRKGKGSIFVWASGNGGKDADSCNCDGYTNSIYTLSISSATENGNIPWYSEACSSTLATTYSSGATGEKM---ILTTDLHHACTNMHTGTSASAPLAAGIVALALEANPNLTWRDLQHIVIRTAK----PINLRAGDWTTNGVGRNVSHSFGYGLMDAGAMVKLAKIWKKVDEQHRCRQFYPSRYKNIPNGNRLQLQLYSDGCYGGADENKVSYVEHVQAIVTLKAPKRGDLQIYLTSPSGTKSTLLTKRAR-DTSRSGFTDWAFMTTHNWGEQAAGLWILEIDNDGWDDAE---LVKWELVLYGT 643          

Query:  475 IVTNQWHVHLHDPATQESANKVAQETGFSVLRNHLNSP-NEFVFHHKTVPHVSSVPSWSQHKVLLAHHLVKNAKQVEGFLRRKRGYKPIKKQGRVPLPTIN-KKGIPGLGESDNIKVDLKLPTDPLFSKEWYIRNTGQADGVKDLDLNVLSAWAQGITGKGVTTAIMDDGIDYLHPDLSKNYNAESSYDFSSNDPYPFPRYTDDWFNSHGTRCAGEISAERDNGICGVGVAYDSKIAGLRMLDQPYMTDLIEAAAMSYDRDNIDIYSASWGPTDDGRTVDGPRNETMRAIVEGVNKGRKGKGSIYVWASXXXXXXXXXXXXXXXXSMWTISINSATNDGETASYDESCSSTLASTFSNGKAWFSLDAGVGTVDLYGQCTLHHSGTSAAAPEAAGVFALALEANSNIGWRDMQHLTVLTSKXXXXXXXXXXXXWTINGAGLEFNHLFGYGVLDAGDMVRVAKKWVNVPERFHCIAGQIDKRYRFNVTKALILEIDTDACKSDIGHRVNYLEHVQAFVSVKSSRRGDITMFLTSPMGTTSMILSHRPKDDDSTRGFTKWPFMTTHTWGENPRGKWKLTVMFDTKDPLSQGIFSEWVLVLHGTQSRPYDKLSSSLEKIIPKLGVVKRQHASNRF 2361
            + T+ + V          A+ VA + GF  L   + +  +E+ F H+T+PH  S  S +  + L +H  V  A Q  GF R KRG +P        +P I+  K    +GE + I  +   PTDP F  +WY++NTGQ  G   LDLNV +AWAQGITGK VTTAIMDDG+DY+HPDL  NYNAE+SYDFSSNDP+P+PRYTDDWFNSHGTRCAGE++A RDNGICGVGVAYDSKIAG+RMLDQPYMTDLIEA +M ++   I IYSASWGPTDDG+TVDGPRN TMRAIV+GVN+GR G G+IYVWASGDGG  DDCNCDGYAASMWTISINSA NDG+ A YDESCSSTLASTFSNG      + GV T DLYG+CT  HSGTSAAAPEAAGVFALALEAN  + WRD+QHLTVLTSKRN L D   R +WT+NG GLEFNHLFG+GVLDAG MV ++K+W +VP R+HC AG++ +     + ++L  EI TDACK      VNYLEHVQA +S  +SRRGD+ +FLTSPMGT SMILS R  DDD   GFTKWPFMTTH+WGE P+G WKL   F++      G   EW LVLHGT+  PY  L  S      KL +VK+ H   + 
Sbjct:   39 VFTSSFLVRFRRGVDNSFAHDVADKYGFDNLGPLVGADGHEYHFKHRTLPHARSRRSLTHTRALKSHPAVHTAVQQPGFKRVKRGLRPA-------VPAIHGMKFDLKVGEGNRIDEE---PTDPYFPMQWYLKNTGQNGGKVRLDLNVQAAWAQGITGKNVTTAIMDDGVDYMHPDLKFNYNAEASYDFSSNDPFPYPRYTDDWFNSHGTRCAGEVAAARDNGICGVGVAYDSKIAGIRMLDQPYMTDLIEANSMGHEPHKIHIYSASWGPTDDGKTVDGPRNATMRAIVQGVNEGRNGLGNIYVWASGDGGEEDDCNCDGYAASMWTISINSAINDGQNAHYDESCSSTLASTFSNGAK--DPNTGVATTDLYGKCTTTHSGTSAAAPEAAGVFALALEANPQLTWRDIQHLTVLTSKRNSLFDAKNRFHWTMNGVGLEFNHLFGFGVLDAGAMVTLSKQWHSVPPRYHCEAGELTQPQAIVMGRSLFWEIKTDACKG-TDTEVNYLEHVQAVISANASRRGDLELFLTSPMGTKSMILSRRANDDDHRDGFTKWPFMTTHSWGEYPQGTWKLEARFNSPQ-TRHGNLLEWSLVLHGTKEAPYRTLHPSSPH--SKLAIVKKAHEDKKM 653          

Query:  475 IVTNQWHVHLHDPATQESANKVAQETGFSVLRNHLNS-PNEFVFHHKTVPHVSSVPSWSQHKVLLAHHLVKNAKQVEGFLRRKRG--YKPIKKQGRVPLPTINKKGIPGLGESDNIKVDLKLPTDPLFSKEWYIRNTGQADGVKDLDLNVLSAWAQGITGKGVTTAIMDDGIDYLHPDLSKNYNAESSYDFSSNDPYPFPRYTDDWFNSHGTRCAGEISAERDNGICGVGVAYDSKIAGLRMLDQPYMTDLIEAAAMSYDRDNIDIYSASWGPTDDGRTVDGPRNETMRAIVEGVNKGRKGKGSIYVWAS-XXXXXXXXXXXXXXXXSMWTISINSATNDGETASYDESCSSTLASTFSNGKAWFSLDAGVGTVDLYGQ------CTLHHSGTSAAAPEAAGVFALALEANSNIGWRDMQHLTVLTSKXXXXXXXXXXXXWTINGAGLEFNHLFGYGVLDAGDMVRVAKKWVNVPERFHCIAGQ--IDKRYRFNVTKALILEIDTDACKSDIGHRVNYLEHVQAFVSVKSSRRGDITMFLTSPMGTTSMILSHRPKDDDSTRGFTKWPFMTTHTWGENPRGKWKLTVMFDTKDPLSQ-GIFSEWVLVLHGTQSRPYDKLSSSLEKIIPKL 2325
            I TN++ V++  PA ++ A+ +A + GF + R  + S  N ++F H  V   S   S      L + + VK  +Q    +RRKR   Y+ +     + L + +++      E  ++      P DPLF ++WY+ N G  DG   LD+NV  AW +G TGKGV  +I+DDGI   HPDL++NY+ E+S+D + ND  P P+  D+  N HGTRCAGE++A   N  CGVGVAY++ I G+RMLD   + D++EA A+S +  +IDIYSASWGP DDG TVDGP     RA + GV  GR+GKGSI+VWAS   G   D CNCDGY  S++T+SI+SAT  G    Y E CSSTLA+T+S+G      D  V TVD+ G       CT+ H+GTSA+AP AAG+ ALALEAN  + WRDMQ+L V TS+       ++ + WT+NG   +++H FGYG++DAG MV +A++W +VP +  C + +   D++        L   +D + C   I + V YLEHVQ  ++++   RG++ + LTSPMGTTS +L  RP+D   +  F  WPF++ H WGE   G+W L V+   +  ++Q GI S+W L+ +GT ++P  +L S L    P+L
Sbjct:  238 IYTNEFAVNI--PAGKQMADVIATKHGF-INRGQIGSLDNYYLFQHHHVSKRSLRSSRKHQGALKSENEVKWMQQQHEKVRRKRDGPYQDLPTYKSISLASHSQRM-----EYRDVSSHFIFP-DPLFKEQWYL-NGGAKDG---LDMNVGPAWQKGYTGKGVVVSILDDGIQTNHPDLAQNYDPEASFDINGNDSDPTPQ--DNGDNKHGTRCAGEVAAVAFNNFCGVGVAYNASIGGVRMLDGK-VNDVVEAQALSLNPSHIDIYSASWGPEDDGSTVDGPGPLARRAFIYGVTSGRQGKGSIFVWASGNGGRYTDSCNCDGYTNSIFTLSISSATQAGFKPWYLEECSSTLATTYSSGTPGH--DKSVATVDMDGSLRPDHICTVEHTGTSASAPLAAGICALALEANPELTWRDMQYLVVYTSR---PAPLEKENGWTLNGVKRKYSHKFGYGLMDAGAMVSLAEQWTSVPPQHICKSRENNEDRKIDGAYGSTLSTHMDVNGCAGTI-NEVRYLEHVQCRITLRFFPRGNLRILLTSPMGTTSTLLFERPRDIVKSN-FDDWPFLSVHFWGEKAEGRWTLQVINGGRRRVNQPGILSKWQLIFYGTSTQPM-RLKSELLNSSPQL 843          

Query:  475 IVTNQWHVHLHDPATQESANKVAQETGFSVLRNHLNS-PNEFVFHHKTVPHVSSVPSWSQHKVLLAHHLVKNAKQVEGFLRRKRG-----------YKPIKKQGRV---PLP-------TINKKGIPGLGESDNIKVDLKLPTDPLFSKEWYI--RNTGQADGVKDLDLNVLSAWAQGITGKGVTTAIMDDGIDYLHPDLSKNYNAESSYDFSSNDPYPFPRYTDDWFNSHGTRCAGEISAERDNGICGVGVAYDSKIAGLRMLDQPYMTDLIEAAAMSYDRDNIDIYSASWGPTDDGRTVDGPRNETMRAIVEGVNKGRKGKGSIYVWAS-XXXXXXXXXXXXXXXXSMWTISINSATNDGETASYDESCSSTLASTFSNGKAWFSLDAGVGTVDLYGQ------CTLHHSGTSAAAPEAAGVFALALEANSNIGWRDMQHLTVLTSKXXXXXXXXXXXXWTINGAGLEFNHLFGYGVLDAGDMVRVAKKWVNVPERFHCIAGQ--IDKRYRFNVTKALILEIDTDACKSDIGHRVNYLEHVQAFVSVKSSRRGDITMFLTSPMGTTSMILSHRPKDDDSTRGFTKWPFMTTHTWGENPRGKWKLTVMFDTKDPLSQ-GIFSEWVLVLHGTQSRPYDKLSSSLEKIIPKL 2325
            I TN++ V++  PA ++ A+ +A + GF + R  + S  N ++F H  V   S   S      L + + VK  +Q    +RRKR            Y  +++ G     P P       +I+        E  ++      P DPLF ++WY+  +N G  DG   LD+NV  AW +G TGKGV  +I+DDGI   HPDL++NY+ E+S+D + ND  P P+  D+  N HGTRCAGE++A   N  CGVGVAY++ I G+RMLD   + D++EA A+S +  +IDIYSASWGP DDG TVDGP     RA + GV  GR+GKGSI+VWAS   G   D CNCDGY  S++T+SI+SAT  G    Y E CSSTLA+T+S+G      D  V TVD+ G       CT+ H+GTSA+AP AAG+ ALALEAN  + WRDMQ+L V TS+       ++ + WT+NG   +++H FGYG++DAG MV +A++W +VP +  C + +   D++        L   +D + C   I + V YLEHVQ  ++++   RG++ + LTSPMGTTS +L  RP+D   +  F  WPF++ H WGE   G+W L V+   +  ++Q GI S+W L+ +GT ++P  +L S L    P+L
Sbjct:  238 IYTNEFAVNI--PAGKQMADVIATKHGF-INRGQIGSLDNYYLFQHHHVSKRSLRSSRKHQGALKSENEVKWMQQQHEKVRRKRDGPYQDLPTYSPYNLLRQHGGYVVDPNPHLSFSPESISLASHSQRMEYRDVSSHFIFP-DPLFKEQWYLVSKNGGAKDG---LDMNVGPAWQKGYTGKGVVVSILDDGIQTNHPDLAQNYDPEASFDINGNDSDPTPQ--DNGDNKHGTRCAGEVAAVAFNNFCGVGVAYNASIGGVRMLDGK-VNDVVEAQALSLNPSHIDIYSASWGPEDDGSTVDGPGPLARRAFIYGVTSGRQGKGSIFVWASGNGGRYTDSCNCDGYTNSIFTLSISSATQAGFKPWYLEECSSTLATTYSSGTPGH--DKSVATVDMDGSLRPDHICTVEHTGTSASAPLAAGICALALEANPELTWRDMQYLVVYTSR---PAPLEKENGWTLNGVKRKYSHKFGYGLMDAGAMVSLAEQWTSVPPQHICKSRENNEDRKIDGAYGSTLSTHMDVNGCAGTI-NEVRYLEHVQCRITLRFFPRGNLRILLTSPMGTTSTLLFERPRDIVKSN-FDDWPFLSVHFWGEKAEGRWTLQVINGGRRRVNQPGILSKWQLIFYGTSTQPM-RLKSELLNSSPQL 870          

Query:  475 IVTNQWHVHLHDPATQESANKVAQETGFSVLRNHLNS-PNEFVFHHKTVPHVSSVPSWSQHKVLLAHHLVKNAKQVEGFLRRKRG-----------YKPIKKQGRV---PLP-------TINKKGIPGLGESDNIKVDLKLPTDPLFSKEWYI--RNTGQADGVKDLDLNVLSAWAQGITGKGVTTAIMDDGIDYLHPDLSKNYNAESSYDFSSNDPYPFPRYTDDWFNSHGTRCAGEISAERDNGICGVGVAYDSKIAGLRMLDQPYMTDLIEAAAMSYDRDNIDIYSASWGPTDDGRTVDGPRNETMRAIVEGVNKGRKGKGSIYVWAS-XXXXXXXXXXXXXXXXSMWTISINSATNDGETASYDESCSSTLASTFSNGKAWFSLDAGVGTVDLYGQ------CTLHHSGTSAAAPEAAGVFALALEANSNIGWRDMQHLTVLTSKXXXXXXXXXXXXWTINGAGLEFNHLFGYGVLDAGDMVRVAKKWVNVPERFHCIAGQ--IDKRYRFNVTKALILEIDTDACKSDIGHRVNYLEHVQAFVSVKSSRRGDITMFLTSPMGTTSMILSHRPKDDDSTRGFTKWPFMTTHTWGENPRGKWKLTVMFDTKDPLSQ-GIFSEWVLVLHGTQSRPYDKLSSSLEKIIPKL 2325
            I TN++ V++  PA ++ A+ +A + GF + R  + S  N ++F H  V   S   S      L + + VK  +Q    +RRKR            Y  +++ G     P P       +I+        E  ++      P DPLF ++WY+  +N G  DG   LD+NV  AW +G TGKGV  +I+DDGI   HPDL++NY+ E+S+D + ND  P P+  D+  N HGTRCAGE++A   N  CGVGVAY++ I G+RMLD   + D++EA A+S +  +IDIYSASWGP DDG TVDGP     RA + GV  GR+GKGSI+VWAS   G   D CNCDGY  S++T+SI+SAT  G    Y E CSSTLA+T+S+G      D  V TVD+ G       CT+ H+GTSA+AP AAG+ ALALEAN  + WRDMQ+L V TS+       ++ + WT+NG   +++H FGYG++DAG MV +A++W +VP +  C + +   D++        L   +D + C   I + V YLEHVQ  ++++   RG++ + LTSPMGTTS +L  RP+D   +  F  WPF++ H WGE   G+W L V+   +  ++Q GI S+W L+ +GT ++P  +L S L    P+L
Sbjct:  238 IYTNEFAVNI--PAGKQMADVIATKHGF-INRGQIGSLDNYYLFQHHHVSKRSLRSSRKHQGALKSENEVKWMQQQHEKVRRKRDGPYQDLPTYSPYNLLRQHGGYVVDPNPHLSFSPESISLASHSQRMEYRDVSSHFIFP-DPLFKEQWYLVSKNGGAKDG---LDMNVGPAWQKGYTGKGVVVSILDDGIQTNHPDLAQNYDPEASFDINGNDSDPTPQ--DNGDNKHGTRCAGEVAAVAFNNFCGVGVAYNASIGGVRMLDGK-VNDVVEAQALSLNPSHIDIYSASWGPEDDGSTVDGPGPLARRAFIYGVTSGRQGKGSIFVWASGNGGRYTDSCNCDGYTNSIFTLSISSATQAGFKPWYLEECSSTLATTYSSGTPGH--DKSVATVDMDGSLRPDHICTVEHTGTSASAPLAAGICALALEANPELTWRDMQYLVVYTSR---PAPLEKENGWTLNGVKRKYSHKFGYGLMDAGAMVSLAEQWTSVPPQHICKSRENNEDRKIDGAYGSTLSTHMDVNGCAGTI-NEVRYLEHVQCRITLRFFPRGNLRILLTSPMGTTSTLLFERPRDIVKSN-FDDWPFLSVHFWGEKAEGRWTLQVINGGRRRVNQPGILSKWQLIFYGTSTQPM-RLKSELLNSSPQL 870          

Query:  475 IVTNQWHVHLHDPATQESANKVAQETGFSVLRNHLNS-PNEFVFHHKTVPHVSSVPSWSQHKVLLAHHLVKNAKQVEGFLRRKRG-----------YKPIKKQGRV---PLP-------TINKKGIPGLGESDNIKVDLKLPTDPLFSKEWYI--RNTGQADGVKDLDLNVLSAWAQGITGKGVTTAIMDDGIDYLHPDLSKNYNAESSYDFSSNDPYPFPRYTDDWFNSHGTRCAGEISAERDNGICGVGVAYDSKIAGLRMLDQPYMTDLIEAAAMSYDRDNIDIYSASWGPTDDGRTVDGPRNETMRAIVEGVNKGRKGKGSIYVWAS-XXXXXXXXXXXXXXXXSMWTISINSATNDGETASYDESCSSTLASTFSNGKAWFSLDAGVGTVDLYGQ------CTLHHSGTSAAAPEAAGVFALALEANSNIGWRDMQHLTVLTSKXXXXXXXXXXXXWTINGAGLEFNHLFGYGVLDAGDMVRVAKKWVNVPERFHCIAGQ--IDKRYRFNVTKALILEIDTDACKSDIGHRVNYLEHVQAFVSVKSSRRGDITMFLTSPMGTTSMILSHRPKDDDSTRGFTKWPFMTTHTWGENPRGKWKLTVMFDTKDPLSQ-GIFSEWVLVLHGTQSRPYDKLSSSLEKIIPKL 2325
            I TN++ V++  PA ++ A+ +A + GF + R  + S  N ++F H  V   S   S      L + + VK  +Q    +RRKR            Y  +++ G     P P       +I+        E  ++      P DPLF ++WY+  +N G  DG   LD+NV  AW +G TGKGV  +I+DDGI   HPDL++NY+ E+S+D + ND  P P+  D+  N HGTRCAGE++A   N  CGVGVAY++ I G+RMLD   + D++EA A+S +  +IDIYSASWGP DDG TVDGP     RA + GV  GR+GKGSI+VWAS   G   D CNCDGY  S++T+SI+SAT  G    Y E CSSTLA+T+S+G      D  V TVD+ G       CT+ H+GTSA+AP AAG+ ALALEAN  + WRDMQ+L V TS+       ++ + WT+NG   +++H FGYG++DAG MV +A++W +VP +  C + +   D++        L   +D + C   I + V YLEHVQ  ++++   RG++ + LTSPMGTTS +L  RP+D   +  F  WPF++ H WGE   G+W L V+   +  ++Q GI S+W L+ +GT ++P  +L S L    P+L
Sbjct:  238 IYTNEFAVNI--PAGKQMADVIATKHGF-INRGQIGSLDNYYLFQHHHVSKRSLRSSRKHQGALKSENEVKWMQQQHEKVRRKRDGPYQDLPTYSPYNLLRQHGGYVVDPNPHLSFSPESISLASHSQRMEYRDVSSHFIFP-DPLFKEQWYLVSKNGGAKDG---LDMNVGPAWQKGYTGKGVVVSILDDGIQTNHPDLAQNYDPEASFDINGNDSDPTPQ--DNGDNKHGTRCAGEVAAVAFNNFCGVGVAYNASIGGVRMLDGK-VNDVVEAQALSLNPSHIDIYSASWGPEDDGSTVDGPGPLARRAFIYGVTSGRQGKGSIFVWASGNGGRYTDSCNCDGYTNSIFTLSISSATQAGFKPWYLEECSSTLATTYSSGTPGH--DKSVATVDMDGSLRPDHICTVEHTGTSASAPLAAGICALALEANPELTWRDMQYLVVYTSR---PAPLEKENGWTLNGVKRKYSHKFGYGLMDAGAMVSLAEQWTSVPPQHICKSRENNEDRKIDGAYGSTLSTHMDVNGCAGTI-NEVRYLEHVQCRITLRFFPRGNLRILLTSPMGTTSTLLFERPRDIVKSN-FDDWPFLSVHFWGEKAEGRWTLQVINGGRRRVNQPGILSKWQLIFYGTSTQPM-RLKSELLNSSPQL 870          

Query:  475 IVTNQWHVHLHDPATQESANKVAQETGFSVLRNHLNSPNEFVFHHKTVPHVSSVPSW-SQHKVLLAHHLVKNAKQVEGFLRRKRGYKPIKKQGRVPLPTINKKGIPGLGESDNIKVDLKLPTDPLFSKEWYIRNTGQADGVKDLDLNVLSAWAQGITGKGVTTAIMDDGIDYLHPDLSKNYNAESSYDFSSNDPYPFPRYTDDWFNSHGTRCAGEISAERDNGICGVGVAYDSKIAGLRMLDQPYMTDLIEAAAMSYDRDNIDIYSASWGPTDDGRTVDGPRNETMRAIVEGVNKGRKGKGSIYVWASXXXXXXXXXXXXXXXXSMWTISINSATNDGETASYDESCSSTLASTFSNGKAWFSLDAGVGTVDLYGQCTLHHSGTSAAAPEAAGVFALALEANSNIGWRDMQHLTVLTSKXXXXXXXXXXXXWTINGAGLEFNHLFGYGVLDAGDMVRVAKKWVNVPERFHCIAGQIDKRYRFNVTKALILEIDTDACKSDIGHRVNYLEHVQAFVSVKSSRRGDITMFLTSPMGTTSMILSHRPKDDDSTRGFTKWPFMTTHTWGENPRGKWKLTVMFDTKDPLSQGIFSEWVLVLHGTQSRPY 2283
             +T  + V + + A  E A K+A E GF   R      + F F+   +P      S   QH  L + H VKN    EGF R+KRGY+ +                       N  V++   +DPLF+K+WY+ NTGQADG   LDLNV  AW+ G TGKGVT AIMDDGIDYLHPDL+ NYNAE+S+DFSSNDPYP+PRYTDDWFNSHGTRCAGE+SA  +N ICGVGVAY+SK+AG+RMLDQP+MTD+IEA+++S+    IDIYSASWGPTDDG+TVDGPR  T++A+ +GVNKGR GKGSIYVWASGDGG+ DDCNCDGYA+SMWTISINSA NDG TA YDESCSSTLASTFSNG+   + +AGV T DLYG CTL HSGTSAAAPEAAGVFALALEAN N+ WRD+QHLTVLTSK       D  H W  NG GLEFNHLFGYGVLDAG MV++A+ W  VPERFHC+AG +   ++      L+L I TDAC+    + V YLEHVQA ++V +SRRGD+ + +TSPMGT S++LS RP+DDD+  GF KWPFMTTHTWGE+PRG W L V F ++  +  G+  EW L+LHGTQS PY
Sbjct:   33 FITGHFLVQMRE-AAPEDAQKLALEHGFESARKLPFGEDLFHFYPLEMPKTRRKRSLHQQHHRLASDHRVKNVFPQEGFGRQKRGYRDLP----------------------NTDVNM---SDPLFTKQWYLINTGQADGTPGLDLNVAEAWSLGFTGKGVTIAIMDDGIDYLHPDLASNYNAEASFDFSSNDPYPYPRYTDDWFNSHGTRCAGEVSAVSNNNICGVGVAYNSKVAGIRMLDQPFMTDIIEASSISHMPQVIDIYSASWGPTDDGKTVDGPRELTLQAMADGVNKGRGGKGSIYVWASGDGGSYDDCNCDGYASSMWTISINSAINDGRTALYDESCSSTLASTFSNGRK-RNPEAGVATTDLYGNCTLRHSGTSAAAPEAAGVFALALEANPNLTWRDLQHLTVLTSK--RNKLHDEVHQWRRNGVGLEFNHLFGYGVLDAGGMVKLARDWKTVPERFHCVAGSMQDIHKIQSGNKLLLSISTDACQGK-DNFVRYLEHVQAVITVNASRRGDLNINMTSPMGTKSILLSRRPRDDDAKVGFDKWPFMTTHTWGEDPRGPWLLEVGFQSQSDMQSGLLKEWTLMLHGTQSAPY 606          

Query:  421 MKITWILLFLCEYV--VCGKIVTNQWHVHLHDPATQESANKVAQETGFSVLRNHLNSPNEFVFHHKTVPHVSSVPSWSQHKVLLAHHLVKNAKQVEGFLRRKRGYKPIKKQGRVPLPTINKKGIPGLGESDNIKVDLKLPTDPLFSKEWYIRNTGQADGVKDLDLNVLSAWAQGITGKGVTTAIMDDGIDYLHPDLSKNYNAESSYDFSSNDPYPFPRYTDDWFNSHGTRCAGEISAERDNGICGVGVAYDSKIAGLRMLDQPYMTDLIEAAAMSYDRDNIDIYSASWGPTDDGRTVDGPRNETMRAIVEGVNKGRKGKGSIYVWAS-XXXXXXXXXXXXXXXXSMWTISINSATNDGETASYDESCSSTLASTFSNGKAWFSLDAGVGTVDLYGQCTLHHSGTSAAAPEAAGVFALALEANSNIGWRDMQHLTVLTSKXXXXXXXXXXXXWTINGAGLEFNHLFGYGVLDAGDMVRVA--KKWVNVPERFHCIAGQIDKRYRFNVTKA---LILEIDTDACKSDIGHRVNYLEHVQAFVSVKSSRRGDITMFLTSPMGTTSMILSHRPKDDDSTRGFTKWPFMTTHTWGENPRGKWKLTVMFDTKDPLSQGIFSEWVLVLHGTQSRP 2280
            M +  +L  +C  V     +   N+W V +  P   ++A  +A E G+ ++R      N ++F         S PS ++     A H+ K   + +     ++ Y+  ++  R PL      G+    E  +  VD KL  DP+++++WY+++T  +  +  LDL+V+  W +GITGKGV   ++DDG+++ H D+  NY+  +SYDF+ NDP PFPRY     N HGTRCAGEI+ + DN  CGVGVAY+SK+ G+RMLD   +TD IEA+++ Y+ D++DIYSASWGP DDG+TV+GP     +A   G+ KGR GKGSI+VWAS   G   D+C+CDGY  S++TISI+SA+  G +  Y E CSSTLA+ +S+G      D  + + DL+ +CT  H+GTSA+AP AAG+FALALE N ++ WRD+QHL V TS+            W  NGAGL  N  FG+G+L+A  +V +A  K W +VPE+  CI    D+ ++    KA   + +EI T AC     + V  LEHVQ  VS++ +RRGD+ + LTSP GTT+++L+ R + D S+ GF  W FM+ HTWGENP G W L +   +    ++G    W L+LHGT  +P
Sbjct:    8 MLLCSVLALVCALVSSAVDRQYLNEWAVEI--PGGVQNARSIADEFGYQLVRQIGALENHYLFKRH------SHPSRTKRS---ADHITKRLSEDDRVSWAEQQYEK-RRAKRAPL------GV----ECKDCSVD-KLFDDPMWNQQWYLQDTRTSSSLPKLDLHVIPVWKKGITGKGVVITVLDDGLEWNHTDIYPNYDPAASYDFNDNDPDPFPRYDSTNENKHGTRCAGEIAMQADNNKCGVGVAYNSKVGGIRMLDG-IVTDAIEASSIGYNPDHVDIYSASWGPNDDGKTVEGPGRLAQKAFEYGIQKGRGGKGSIFVWASGNGGRQGDNCDCDGYTDSLYTISISSASQQGLSPWYAEKCSSTLATAYSSGDY---TDQRITSADLHNECTETHTGTSASAPLAAGIFALALEQNPDLTWRDLQHLVVWTSE---FDPLANNPGWKRNGAGLMVNSRFGFGLLNAKALVDLADPKVWKHVPEKKQCIVR--DETFQPRPLKAAGEISIEIPTKACAGQ-ANSVMSLEHVQVEVSIEYTRRGDLHITLTSPSGTTTVLLAERER-DTSSNGFRNWAFMSVHTWGENPTGTWILKITDTSGRMENEGQIISWKLILHGTSEKP 601          

Query:  421 MKITWILLFLCEYV--VCGKIVTNQWHVHLHDPATQESANKVAQETGFSVLRNHLNSPNEFVFHHKTVPHVSSVPSWSQHKVLLAHHLVKNAKQVEGFLRRKRGYKPIKKQGRVPLPTINKKGIPGLGESDNIKVDLKLPTDPLFSKEWYIRNTGQADGVKDLDLNVLSAWAQGITGKGVTTAIMDDGIDYLHPDLSKNYNAESSYDFSSNDPYPFPRYTDDWFNSHGTRCAGEISAERDNGICGVGVAYDSKIAGLRMLDQPYMTDLIEAAAMSYDRDNIDIYSASWGPTDDGRTVDGPRNETMRAIVEGVNKGRKGKGSIYVWAS-XXXXXXXXXXXXXXXXSMWTISINSATNDGETASYDESCSSTLASTFSNGKAWFSLDAGVGTVDLYGQCTLHHSGTSAAAPEAAGVFALALEANSNIGWRDMQHLTVLTSKXXXXXXXXXXXXWTINGAGLEFNHLFGYGVLDAGDMVRVA--KKWVNVPERFHCIAGQIDKRYRFNVTKA---LILEIDTDACKSDIGHRVNYLEHVQAFVSVKSSRRGDITMFLTSPMGTTSMILSHRPKDDDSTRGFTKWPFMTTHTWGENPRGKWKLTVMFDTKDPLSQGIFSEWVLVLHGTQSRP 2280
            M +  +L  +C  V     +   N+W V +  P   ++A  +A E G+ ++R      N ++F         S PS ++     A H+ K   + +     ++ Y+  ++  R PL      G+    E  +  VD KL  DP+++++WY+++T  +  +  LDL+V+  W +GITGKGV   ++DDG+++ H D+  NY+  +SYDF+ NDP PFPRY     N HGTRCAGEI+ + DN  CGVGVAY+SK+ G+RMLD   +TD IEA+++ Y+ D++DIYSASWGP DDG+TV+GP     +A   G+ KGR GKGSI+VWAS   G   D+C+CDGY  S++TISI+SA+  G +  Y E CSSTLA+ +S+G      D  + + DL+ +CT  H+GTSA+AP AAG+FALALE N ++ WRD+QHL V TS+            W  NGAGL  N  FG+G+L+A  +V +A  K W +VPE+  CI    D+ ++    KA   + +EI T AC     + V  LEHVQ  VS++ +RRGD+ + LTSP GTT+++L+ R + D S+ GF  W FM+ HTWGENP G W L +   +    ++G    W L+LHGT  +P
Sbjct:    8 MLLCSVLALVCALVSSAVDRQYLNEWAVEI--PGGVQNARSIADEFGYQLVRQIGALENHYLFKRH------SHPSRTKRS---ADHITKRLSEDDRVSWAEQQYEK-RRAKRAPL------GV----ECKDCSVD-KLFDDPMWNQQWYLQDTRTSSSLPKLDLHVIPVWKKGITGKGVVITVLDDGLEWNHTDIYPNYDPAASYDFNDNDPDPFPRYDSTNENKHGTRCAGEIAMQADNNKCGVGVAYNSKVGGIRMLDG-IVTDAIEASSIGYNPDHVDIYSASWGPNDDGKTVEGPGRLAQKAFEYGIQKGRGGKGSIFVWASGNGGRQGDNCDCDGYTDSLYTISISSASQQGLSPWYAEKCSSTLATAYSSGDY---TDQRITSADLHNECTETHTGTSASAPLAAGIFALALEQNPDLTWRDLQHLVVWTSE---FDPLANNPGWKRNGAGLMVNSRFGFGLLNAKALVDLADPKVWKHVPEKKQCIVR--DETFQPRPLKAAGEISIEIPTKACAGQ-ANSVMSLEHVQVEVSIEYTRRGDLHITLTSPSGTTTVLLAERER-DTSSNGFRNWAFMSVHTWGENPTGTWILKITDTSGRMENEGQIISWKLILHGTSEKP 601          

Query:  472 KIVTNQWHVHLHDPATQESANKVAQETGFSVLRNHLNSPNEFV-FHHKTVPHVSSVPSWSQHKVLLAHHLVKNAKQVEGFLRRKRGYKPIKKQGRVPLPTINKKGIPGLGESDNIKVDLKLPTDPLFSKEWYIRNTGQADGVKDLDLNVLSAWAQGITGKGVTTAIMDDGIDYLHPDLSKNYNAESSYDFSSNDPYPFPRYTDDWFNSHGTRCAGEISAERDNGICGVGVAYDSKIAGLRMLDQPYMTDLIEAAAMSYDRDNIDIYSASWGPTDDGRTVDGPRNETMRAIVEGVNKGRKGKGSIYVWASXXXXXXX-XXXXXXXXXSMWTISINSATNDGETASYDESCSSTLASTFSNGKAWFSLDAGVGTVDLYGQCTLHHSGTSAAAPEAAGVFALALEANSNIGWRDMQHLTVLTSKXXXXXXXXXXXXWTINGAGLEFNHLFGYGVLDAGDMVRVAKKWVNVPERFHCIAGQIDKRYRFNVTKALILEIDTDACKSDIGHRVNYLEHVQAFVSVKSSRRGDITMFLTSPMGTTSMILSHRPKDDDSTRGFTKWPFMTTHTWGENPRGKWKLTVMFDTKDPLSQGIFSEWVLVLHGTQS 2274
            K+ TN W VH+     +E A+++A++  F    NH N   ++  F H+TV   S       H  L     V  A+Q     R+KR                            ++  +   PTDP F+++WY+ N         LDLNV +AW QG+TG+GV  +I+DDGI+  HPDL +NY+ ++SYD +  DP P PRYT    N HGTRCAGE++A  DN ICGVGVAY+++I G+RMLD   +TD++EA ++S +  +IDIYSASWGP DDG+TVDGP      A   GV +GR G+GSI+VWASG+GG     CNCDGY  S++T+SI+S+T +G    Y E+CSSTLAST+S+G      +  + T DL  +CT  H+GTSA+AP AAG+ ALALEAN N+ WRDMQHL V TS           ++W ING G   +H +GYG+LDAG +V +AK W NV  +  C+   + +    N+   L++    DAC + + + V+ LEHVQA +++  +RRG++ ++L SP GT S +L  RP  D S+ GF  W FMTTH+W E+PRG+W L +  +       G  +++ LVL+GT S
Sbjct:   28 KVYTNTWAVHIE--GGEEEADRIARKHSFV---NHGNVFGDYYHFRHRTVVKRSLSEHRGTHIRLHTEPQVMWAEQQVVKRRKKR----------------------------DVYYE---PTDPKFAQQWYLYNQDH------LDLNVKNAWKQGVTGQGVVVSILDDGIEKNHPDLVQNYDPDASYDVNDGDPDPQPRYTQLNDNRHGTRCAGEVAAVADNDICGVGVAYNARIGGVRMLDGE-VTDVVEAQSLSLNPQHIDIYSASWGPEDDGKTVDGPAKLAKEAFQRGVIEGRGGRGSIFVWASGNGGRMKDSCNCDGYTNSIYTLSISSSTQNGNVPWYSEACSSTLASTYSSGGV---NEKQIVTTDLRQKCTDSHTGTSASAPLAAGIIALALEANKNLTWRDMQHLVVRTSN----PAHLTTNDWKINGVGRRVSHSYGYGLLDAGAIVALAKNWTNVGPQHKCVLSLVSEPR--NIGSYLVINKTVDAC-TGMANFVSSLEHVQAQLTLSYNRRGNLAIYLISPQGTRSTLLPPRPH-DYSSEGFNDWAFMTTHSWDEDPRGEWTLEIK-NVAGTSDYGTLTQFTLVLYGTAS 575          

Query:  472 KIVTNQWHVHLHDPATQESANKVAQETGFSVLRNHLNSPNEFV-FHHKTVPHVSSVPSWSQHKVLLAHHLVKNAKQVEGFLRRKRGYKPIKKQGRVPLPTINKKGIPGLGESDNIKVDLKLPTDPLFSKEWYIRNTGQADGVKDLDLNVLSAWAQGITGKGVTTAIMDDGIDYLHPDLSKNYNAESSYDFSSNDPYPFPRYTDDWFNSHGTRCAGEISAERDNGICGVGVAYDSKIAGLRMLDQPYMTDLIEAAAMSYDRDNIDIYSASWGPTDDGRTVDGPRNETMRAIVEGVNKGRKGKGSIYVWASXXXXXXX-XXXXXXXXXSMWTISINSATNDGETASYDESCSSTLASTFSNGKAWFSLDAGVGTVDLYGQCTLHHSGTSAAAPEAAGVFALALEANSNIGWRDMQHLTVLTSKXXXXXXXXXXXXWTINGAGLEFNHLFGYGVLDAGDMVRVAKKWVNVPERFHCIAGQIDKRYRFNVTKALILEIDTDACKSDIGHRVNYLEHVQAFVSVKSSRRGDITMFLTSPMGTTSMILSHRPKDDDSTRGFTKWPFMTTHTWGENPRGKWKLTVMFDTKDPLSQGIFSEWVLVLHGTQS 2274
            K+ TN W VH+     +E A+++A++  F    NH N   ++  F H+TV   S       H  L     V  A+Q     R+KR                            ++  +   PTDP F+++WY+ N         LDLNV +AW QG+TG+GV  +I+DDGI+  HPDL +NY+ ++SYD +  DP P PRYT    N HGTRCAGE++A  DN ICGVGVAY+++I G+RMLD   +TD++EA ++S +  +IDIYSASWGP DDG+TVDGP      A   GV +GR G+GSI+VWASG+GG     CNCDGY  S++T+SI+S+T +G    Y E+CSSTLAST+S+G      +  + T DL  +CT  H+GTSA+AP AAG+ ALALEAN N+ WRDMQHL V TS           ++W ING G   +H +GYG+LDAG +V +AK W NV  +  C+   + +    N+   L++    DAC + + + V+ LEHVQA +++  +RRG++ ++L SP GT S +L  RP  D S+ GF  W FMTTH+W E+PRG+W L +  +       G  +++ LVL+GT S
Sbjct:   28 KVYTNTWAVHIE--GGEEEADRIARKHSFV---NHGNVFGDYYHFRHRTVVKRSLSEHRGTHIRLHTEPQVMWAEQQVVKRRKKR----------------------------DVYYE---PTDPKFAQQWYLYNQDH------LDLNVKNAWKQGVTGQGVVVSILDDGIEKNHPDLVQNYDPDASYDVNDGDPDPQPRYTQLNDNRHGTRCAGEVAAVADNDICGVGVAYNARIGGVRMLDGE-VTDVVEAQSLSLNPQHIDIYSASWGPEDDGKTVDGPAKLAKEAFQRGVIEGRGGRGSIFVWASGNGGRMKDSCNCDGYTNSIYTLSISSSTQNGNVPWYSEACSSTLASTYSSGGV---NEKQIVTTDLRQKCTDSHTGTSASAPLAAGIIALALEANKNLTWRDMQHLVVRTSN----PAHLTTNDWKINGVGRRVSHSYGYGLLDAGAIVALAKNWTNVGPQHKCVLSLVSEPR--NIGSYLVINKTVDAC-TGMANFVSSLEHVQAQLTLSYNRRGNLAIYLISPQGTRSTLLPPRPH-DYSSEGFNDWAFMTTHSWDEDPRGEWTLEIK-NVAGTSDYGTLTQFTLVLYGTAS 575          

Query:  436 ILLFLCEYVVCG--KIVTNQWHVHLHDPATQESANKVAQETGFSVLRNHLNSPNEFVFHHKTVPHVSSVPSWSQHKVLLAHHLVKNAKQVEGFLRRKRGYKPIKKQGRVPLPTINKKGIPGLGESDNIKVDLKLPTDPLFSKEWYIRNTGQADGVKDLDLNVLSAWAQGITGKGVTTAIMDDGIDYLHPDLSKNYNAESSYDFSSNDPYPFPRYTDDWFNSHGTRCAGEISAERDNGICGVGVAYDSKIAGLRMLDQPYMTDLIEAAAMSYDRDNIDIYSASWGPTDDGRTVDGPRNETMRAIVEGVNKGRKGKGSIYVWASXXXXXXXXXXXXXXXXSMWTISINSATNDGETASYDESCSSTLASTFSNGKAWFSLDAGVGTVDLYGQCTLHHSGTSAAAPEAAGVFALALEANSNIGWRDMQHLTVLTSKXXXXXXXXXXXXWTINGAGLEFNHLFGYGVLDAGDMVRVAKKWVNVPERFHCIAGQIDKRYRFNVTKALILEIDTDACKSDIGHRVNYLEHVQAFVSVKSSRRGDITMFLTSPMGTTSMILSHRPKDDDSTRGFTKWPFMTTHTWGENPRGKWKLTVMFDTKDPLSQGIFSEWVLVLHGTQSRPY 2283
            ++L L   +V     ++T+ + V L +    E A ++A E GFS  R    + + + F+        S  S ++ K L     +    Q EGF R+KRGY+ I                      ++I +++    DPLF+K+WY+ NTGQADG   LDLNV  AW  G TG+GVT AIMDDGIDYLHPDL+ NYNAE+SYDFSSNDPYP+PRYTDDWFNSHGTRCAGE+SA  +N ICGVGVAY+SK+AG+RMLDQP+MTD+IEA+++S+    IDIYSASWGPTDDG+TVDGPR  T++A+ +GVNKGR GKGSIYVWASGDGG+ DDCNCDGYA+SMWTISINSA NDG TA YDESCSSTLASTFSNG+   + +AGV T DLYG CTL HSGTSAAAPEAAGVFALALEAN  + WRD+QHLTVLTSK       D  H W  NG GLEFNHLFGYGVLDAG MV++A +W  VPERFHCI G I +  R      LIL + TDAC+    + V YLEHVQA ++V S+RRGD+ + +TSPMGT S++LS RP+DDDS  GF KWPFMTTHTWGE+PRG W L V F    P  +G+  EW L+LHGTQS PY
Sbjct:   14 LVLHLASVLVSAGRPVLTDHFLVDLREGGEAE-AKQLAAEYGFSGTRKLPFTQSLYHFYGNGKTTSRSRRSVNKKKHLAMDPKINKVVQQEGFHRKKRGYRDI----------------------NDIDINMN---DPLFTKQWYLINTGQADGTPGLDLNVAEAWELGYTGRGVTIAIMDDGIDYLHPDLASNYNAEASYDFSSNDPYPYPRYTDDWFNSHGTRCAGEVSAAANNNICGVGVAYNSKVAGIRMLDQPFMTDIIEASSISHMPQVIDIYSASWGPTDDGKTVDGPRELTLQAMADGVNKGRGGKGSIYVWASGDGGSYDDCNCDGYASSMWTISINSAINDGRTALYDESCSSTLASTFSNGRK-RNPEAGVATTDLYGNCTLRHSGTSAAAPEAAGVFALALEANPGLTWRDLQHLTVLTSK--RNQLHDEVHKWRRNGVGLEFNHLFGYGVLDAGAMVKMANEWKTVPERFHCIGGAIQEPRRIPSDGKLILTLSTDACEGK-ENFVRYLEHVQAVITVNSTRRGDLNINMTSPMGTKSILLSRRPRDDDSKVGFDKWPFMTTHTWGEDPRGTWVLEVGFVGSMP-EKGVLKEWTLMLHGTQSAPY 600          

Query:  475 IVTNQWHVHLHDPATQESANKVAQETGFSVLRNHLNSPNEFVFHHKTVPHVSSVPSWSQHKVLLAHHLVKNAKQVEGFLRRKRGYKPIKKQGRVPLPTINKKGIPGLGESDNIKVDLKLPTDPLFSKEWYIRNTGQADGVKDLDLNVLSAWAQGITGKGVTTAIMDDGIDYLHPDLSKNYNAESSYDFSSNDPYPFPRYTDDWFNSHGTRCAGEISAERDNGICGVGVAYDSKIAGLRMLDQPYMTDLIEAAAMSYDRDNIDIYSASWGPTDDGRTVDGPRNETMRAIVEGVNKGRKGKGSIYVWASXXXXXXXXXXXXXXXXSMWTISINSATNDGETASYDESCSSTLASTFSNGKAWFSLDAGVGTVDLYGQCTLHHSGTSAAAPEAAGVFALALEANSNIGWRDMQHLTVLTSKXXXXXXXXXXXXWTINGAGLEFNHLFGYGVLDAGDMVRVAKKWVNVPERFHCIAGQIDKRYRFNVTKALILEIDTDACKSDIGHRVNYLEHVQAFVSVKSSRRGDITMFLTSPMGTTSMILSHRPKDDDSTRGFTKWPFMTTHTWGENPRGKWKLTVMFDTKDPLSQGIFSEWVLVLHGTQSRPY 2283
            ++T+ + V L +    E A ++A E GFS  R    + + + F+        S  S ++ K L     +    Q EGF R+KRGY+ I                      ++I +++    DPLF+K+WY+ NTGQADG   LDLNV  AW  G TG+GVT AIMDDGIDYLHPDL+ NYNAE+SYDFSSNDPYP+PRYTDDWFNSHGTRCAGE+SA  +N ICGVGVAY+SK+AG+RMLDQP+MTD+IEA+++S+    IDIYSASWGPTDDG+TVDGPR  T++A+ +GVNKGR GKGSIYVWASGDGG+ DDCNCDGYA+SMWTISINSA NDG TA YDESCSSTLASTFSNG+   + +AGV T DLYG CTL HSGTSAAAPEAAGVFALALEAN  + WRD+QHLTVLTSK       D  H W  NG GLEFNHLFGYGVLDAG MV++A +W  VPERFHCI G I +  R      LIL + TDAC+    + V YLEHVQA ++V S+RRGD+ + +TSPMGT S++LS RP+DDDS  GF KWPFMTTHTWGE+PRG W L V F    P  +G+  EW L+LHGTQS PY
Sbjct:   17 VLTDHFLVDLREGGEAE-AKQLAAEYGFSGTRKLPFTQSLYHFYGNGKTTSRSRRSVNKKKHLAMDPKINKVVQQEGFHRKKRGYRDI----------------------NDIDINMN---DPLFTKQWYLINTGQADGTPGLDLNVAEAWELGYTGRGVTIAIMDDGIDYLHPDLASNYNAEASYDFSSNDPYPYPRYTDDWFNSHGTRCAGEVSAAANNNICGVGVAYNSKVAGIRMLDQPFMTDIIEASSISHMPQVIDIYSASWGPTDDGKTVDGPRELTLQAMADGVNKGRGGKGSIYVWASGDGGSYDDCNCDGYASSMWTISINSAINDGRTALYDESCSSTLASTFSNGRK-RNPEAGVATTDLYGNCTLRHSGTSAAAPEAAGVFALALEANPGLTWRDLQHLTVLTSK--RNQLHDEVHKWRRNGVGLEFNHLFGYGVLDAGAMVKMANEWKTVPERFHCIGGAIQEPRRIPSDGKLILTLSTDACEGK-ENFVRYLEHVQAVITVNSTRRGDLNINMTSPMGTKSILLSRRPRDDDSKVGFDKWPFMTTHTWGEDPRGTWVLEVGFVGSMP-EKGVLKEWTLMLHGTQSAPY 588          

Query:  436 ILLFLCEYVVCG--KIVTNQWHVHLHDPATQESANKVAQETGFSVLRNHLNSPNEFVFHHKTVPHVSSVPSWSQHKVLLAHHLVKNAKQVEGFLRRKRGYKPIKKQGRVPLPTINKKGIPGLGESDNIKVDLKLPTDPLFSKEWYIRNTGQADGVKDLDLNVLSAWAQGITGKGVTTAIMDDGIDYLHPDLSKNYNAESSYDFSSNDPYPFPRYTDDWFNSHGTRCAGEISAERDNGICGVGVAYDSKIAGLRMLDQPYMTDLIEAAAMSYDRDNIDIYSASWGPTDDGRTVDGPRNETMRAIVEGVNKGRKGKGSIYVWASXXXXXXXXXXXXXXXXSMWTISINSATNDGETASYDESCSSTLASTFSNGKAWFSLDAGVGTVDLYGQCTLHHSGTSAAAPEAAGVFALALEANSNIGWRDMQHLTVLTSKXXXXXXXXXXXXWTINGAGLEFNHLFGYGVLDAGDMVRVAKKWVNVPERFHCIAGQIDKRYRFNVTKALILEIDTDACKSDIGHRVNYLEHVQAFVSVKSSRRGDITMFLTSPMGTTSMILSHRPKDDDSTRGFTKWPFMTTHTWGENPRGKWKLTVMFDTKDPLSQGIFSEWVLVLHGTQSRPY 2283
            ++L L   +V     ++T+ + V L +    E A ++A E GFS  R    + + + F+        S  S ++ K L     +    Q EGF R+KRGY+ I                      ++I +++    DPLF+K+WY+ NTGQADG   LDLNV  AW  G TG+GVT AIMDDGIDYLHPDL+ NYNAE+SYDFSSNDPYP+PRYTDDWFNSHGTRCAGE+SA  +N ICGVGVAY+SK+AG+RMLDQP+MTD+IEA+++S+    IDIYSASWGPTDDG+TVDGPR  T++A+ +GVNKGR GKGSIYVWASGDGG+ DDCNCDGYA+SMWTISINSA NDG TA YDESCSSTLASTFSNG+   + +AGV T DLYG CTL HSGTSAAAPEAAGVFALALEAN  + WRD+QHLTVLTSK       D  H W  NG GLEFNHLFGYGVLDAG MV++A +W  VPERFHCI G I +  R      LIL + TDAC+    + V YLEHVQA ++V S+RRGD+ + +TSPMGT S++LS RP+DDDS  GF KWPFMTTHTWGE+PRG W L V F    P  +G+  EW L+LHGTQS PY
Sbjct:   14 LVLHLASVLVSAGRPVLTDHFLVDLREGGEAE-AKQLAAEYGFSGTRKLPFTQSLYHFYGNGKTTSRSRRSVNKKKHLAMDPKINKVVQQEGFHRKKRGYRDI----------------------NDIDINMN---DPLFTKQWYLINTGQADGTPGLDLNVAEAWELGYTGRGVTIAIMDDGIDYLHPDLASNYNAEASYDFSSNDPYPYPRYTDDWFNSHGTRCAGEVSAAANNNICGVGVAYNSKVAGIRMLDQPFMTDIIEASSISHMPQVIDIYSASWGPTDDGKTVDGPRELTLQAMADGVNKGRGGKGSIYVWASGDGGSYDDCNCDGYASSMWTISINSAINDGRTALYDESCSSTLASTFSNGRK-RNPEAGVATTDLYGNCTLRHSGTSAAAPEAAGVFALALEANPGLTWRDLQHLTVLTSK--RNQLHDEVHKWRRNGVGLEFNHLFGYGVLDAGAMVKMANEWKTVPERFHCIGGAIQEPRRIPSDGKLILTLSTDACEGK-ENFVRYLEHVQAVITVNSTRRGDLNINMTSPMGTKSILLSRRPRDDDSKVGFDKWPFMTTHTWGEDPRGTWVLEVGFVGSMP-EKGVLKEWTLMLHGTQSAPY 600          

Query:  475 IVTNQWHVHLHDPATQESANKVAQETGFSVLRNHLNSPNEFVFHHKTVPHVSSVPSWSQHKVLLAHHLVKNAKQVEGFLRRKRGYKPIKKQGRVPLPTINKKGIPGLGESDNIKVDLKLPTDPLFSKEWYIRNTGQADGVKDLDLNVLSAWAQGITGKGVTTAIMDDGIDYLHPDLSKNYNAESSYDFSSNDPYPFPRYTDDWFNSHGTRCAGEISAERDNGICGVGVAYDSKIAGLRMLDQPYMTDLIEAAAMSYDRDNIDIYSASWGPTDDGRTVDGPRNETMRAIVEGVNKGRKGKGSIYVWASXXXXXXXXXXXXXXXXSMWTISINSATNDGETASYDESCSSTLASTFSNGKAWFSLDAGVGTVDLYGQCTLHHSGTSAAAPEAAGVFALALEANSNIGWRDMQHLTVLTSKXXXXXXXXXXXXWTINGAGLEFNHLFGYGVLDAGDMVRVAKKWVNVPERFHCIAGQIDKRYRFNVTKALILEIDTDACKSDIGHRVNYLEHVQAFVSVKSSRRGDITMFLTSPMGTTSMILSHRPKDDDSTRGFTKWPFMTTHTWGENPRGKWKLTVMFDTKDPLSQGIFSEWVLVLHGTQSRPY 2283
            ++T+ + V L +    E A ++A E GFS  R    + + + F+        S  S ++ K L     +    Q EGF R+KRGY+ I                      ++I +++    DPLF+K+WY+ NTGQADG   LDLNV  AW  G TG+GVT AIMDDGIDYLHPDL+ NYNAE+SYDFSSNDPYP+PRYTDDWFNSHGTRCAGE+SA  +N ICGVGVAY+SK+AG+RMLDQP+MTD+IEA+++S+    IDIYSASWGPTDDG+TVDGPR  T++A+ +GVNKGR GKGSIYVWASGDGG+ DDCNCDGYA+SMWTISINSA NDG TA YDESCSSTLASTFSNG+   + +AGV T DLYG CTL HSGTSAAAPEAAGVFALALEAN  + WRD+QHLTVLTSK       D  H W  NG GLEFNHLFGYGVLDAG MV++A +W  VPERFHCI G I +  R      LIL + TDAC+    + V YLEHVQA ++V S+RRGD+ + +TSPMGT S++LS RP+DDDS  GF KWPFMTTHTWGE+PRG W L V F    P  +G+  EW L+LHGTQS PY
Sbjct:   26 VLTDHFLVDLREGGEAE-AKQLAAEYGFSGTRKLPFTQSLYHFYGNGKTTSRSRRSVNKKKHLAMDPKINKVVQQEGFHRKKRGYRDI----------------------NDIDINMN---DPLFTKQWYLINTGQADGTPGLDLNVAEAWELGYTGRGVTIAIMDDGIDYLHPDLASNYNAEASYDFSSNDPYPYPRYTDDWFNSHGTRCAGEVSAAANNNICGVGVAYNSKVAGIRMLDQPFMTDIIEASSISHMPQVIDIYSASWGPTDDGKTVDGPRELTLQAMADGVNKGRGGKGSIYVWASGDGGSYDDCNCDGYASSMWTISINSAINDGRTALYDESCSSTLASTFSNGRK-RNPEAGVATTDLYGNCTLRHSGTSAAAPEAAGVFALALEANPGLTWRDLQHLTVLTSK--RNQLHDEVHKWRRNGVGLEFNHLFGYGVLDAGAMVKMANEWKTVPERFHCIGGAIQEPRRIPSDGKLILTLSTDACEGK-ENFVRYLEHVQAVITVNSTRRGDLNINMTSPMGTKSILLSRRPRDDDSKVGFDKWPFMTTHTWGEDPRGTWVLEVGFVGSMP-EKGVLKEWTLMLHGTQSAPY 597          

Query:  676 LVKNAKQVEGFLRRKRGYKPIKKQGRVPLPTINKKGIPGLGESDNIKVDLKLPTDPLFSKEWYIRNTGQADGVKDLDLNVLSAWAQGITGKGVTTAIMDDGIDYLHPDLSKNYNAESSYDFSSNDPYPFPRYTDDWFNSHGTRCAGEISAERDNGICGVGVAYDSKIAGLRMLDQPYMTDLIEAAAMSYDRDNIDIYSASWGPTDDGRTVDGPRNETMRAIVEGVNKGRKGKGSIYVWASXXXXXXXXXXXXXXXXSMWTISINSATNDGETASYDESCSSTLASTFSNGKAWFSLDAGVGTVDLYGQCTLHHSGTSAAAPEAAGVFALALEANSNIGWRDMQHLTVLTSKXXXXXXXXXXXXWTINGAGLEFNHLFGYGVLDAGDMVRVAKKWVNVPERFHCIAGQIDKRYRFNVTKALILEIDTDACKSDIGHRVNYLEHVQAFVSVKSSRRGDITMFLTSPMGTTSMILSHRPKDDDSTRGFTKWPFMTTHTWGENPRGKWKLTVMFDTKDPLSQGIFSEWVLVLHGTQSRPY 2283
            L+    Q EGF R+KRGY+ I                      ++I +++    DPLF+K+WY+ NTGQADG   LDLNV  AW  G TG+GVT AIMDDGIDYLHPDL+ NYNAE+SYDFSSNDPYP+PRYTDDWFNSHGTRCAGE+SA  +N ICGVGVAY+SK+AG+RMLDQP+MTD+IEA+++S+    IDIYSASWGPTDDG+TVDGPR  T++A+ +GVNKGR GKGSIYVWASGDGG+ DDCNCDGYA+SMWTISINSA NDG TA YDESCSSTLASTFSNG+   + +AGV T DLYG CTL HSGTSAAAPEAAGVFALALEAN  + WRD+QHLTVLTSK       D  H W  NG GLEFNHLFGYGVLDAG MV++A +W  VPERFHCI G I +  R      LIL + TDAC+    + V YLEHVQA ++V S+RRGD+ + +TSPMGT S++LS RP+DDDS  GF KWPFMTTHTWGE+PRG W L V F    P  +G+  EW L+LHGTQS PY
Sbjct:   72 LINKVVQQEGFHRKKRGYRDI----------------------NDIDINMN---DPLFTKQWYLINTGQADGTPGLDLNVAEAWELGYTGRGVTIAIMDDGIDYLHPDLASNYNAEASYDFSSNDPYPYPRYTDDWFNSHGTRCAGEVSAAANNNICGVGVAYNSKVAGIRMLDQPFMTDIIEASSISHMPQVIDIYSASWGPTDDGKTVDGPRELTLQAMADGVNKGRGGKGSIYVWASGDGGSYDDCNCDGYASSMWTISINSAINDGRTALYDESCSSTLASTFSNGRK-RNPEAGVATTDLYGNCTLRHSGTSAAAPEAAGVFALALEANPGLTWRDLQHLTVLTSK--RNQLHDEVHKWRRNGVGLEFNHLFGYGVLDAGAMVKMANEWKTVPERFHCIGGAIQEPRRIPSDGKLILTLSTDACEGK-ENFVRYLEHVQAVITVNSTRRGDLNINMTSPMGTKSILLSRRPRDDDSKVGFDKWPFMTTHTWGEDPRGTWVLEVGFVGSMP-EKGVLKEWTLMLHGTQSAPY 577          

Query:  475 IVTNQWHVHLHDPATQESANKVAQETGFSVLRNHLNSPNEFVFHHKTVPHVSSVPSWSQHKVLLAHHLVKNAKQVEGFLRRKRGYKPIKKQGRVPLPTINKKGIPGLGESDNIKVDLKLPTDPLFSKEWYIRNTGQADGVKDLDLNVLSAWAQGITGKGVTTAIMDDGIDYLHPDLSKNYNAESSYDFSSNDPYPFPRYTDDWFNSHGTRCAGEISAERDNGICGVGVAYDSKIAGLRMLDQPYMTDLIEAAAMSYDRDNIDIYSASWGPTDDGRTVDGPRNETMRAIVEGVNKGRKGKGSIYVWASXXXXXXXXXXXXXXXXSMWTISINSATNDGETASYDESCSSTLASTFSNGKAWFSLDAGVGTVDLYGQCTLHHSGTSAAAPEAAGVFALALEANSNIGWRDMQHLTVLTSKXXXXXXXXXXXXWTINGAGLEFNHLFGYGVLDAGDMVRVAKKWVNVPERFHCIAGQIDKRYRFNVTKALILEIDTDACKSDIGHRVNYLEHVQAFVSVKSSRRGDITMFLTSPMGTTSMILSHRPKDDDSTRGFTKWPFMTTHTWGENPRGKWKLTVMFDTKDPLSQGIFSEWVLVLHGTQSRPYDKLSSSLEKIIPKLGVVKRQHASNRFSQ 2367
            + TN + V LH    +E A +VA E GF V R    +   + F+H  +       S    + L     +K A Q EGF R+KRGY+ I +                        +D+ +  DPLF+K+WY+ NTGQADG   LDLNV  AW  G TGKGVT  IMDDGIDYLHPDL+ NYNA++SYDFSSNDPYP+PRYTDDWFNSHGTRCAGE+SA   N ICGVGVAY+SK+AG+RMLDQP+MTD+IEA+++S+    IDIYSASWGPTD+G+TVDGPR  T++A+ +GVNKGR GKGSIYVWASGDGG+ DDCNCDGYA+SMWTISINSA NDG TA YDESCSSTLASTFSNG+   + +AGV T DLYG CTL HSGTSAAAPEAAGVFALALEAN ++ WRDMQHLTVLTSK       D  H W  NG GLEFNHLFGYGVLDAG MV++AK W  VPERFHC+ G +    +   T  L+L + T+AC+    + V YLEHVQA ++V ++RRGD+ + +TSPMGT S++LS RP+DDDS  GF KWPFMTTHTWGE+ RG W L + F    P  +G+  EW L+LHGTQS PY  +   +     KL + K+Q       +
Sbjct:   28 VFTNHFLVELHKDG-EEEARQVAAEHGFGV-RKLPFAEGLYHFYHNGLAKAKRRRSLHHKRQLERDPRIKMALQQEGFDRKKRGYRDINE------------------------IDINM-NDPLFTKQWYLFNTGQADGTPGLDLNVAEAWELGYTGKGVTIGIMDDGIDYLHPDLAYNYNADASYDFSSNDPYPYPRYTDDWFNSHGTRCAGEVSAAASNNICGVGVAYNSKVAGIRMLDQPFMTDIIEASSISHMPQLIDIYSASWGPTDNGKTVDGPRELTLQAMADGVNKGRGGKGSIYVWASGDGGSYDDCNCDGYASSMWTISINSAINDGRTALYDESCSSTLASTFSNGRK-RNPEAGVATTDLYGNCTLRHSGTSAAAPEAAGVFALALEANLDLTWRDMQHLTVLTSK--RNQLHDEVHQWRRNGVGLEFNHLFGYGVLDAGAMVKMAKDWKTVPERFHCVGGSVQNPEKIPPTGKLVLTLKTNACEGK-ENFVRYLEHVQAVITVNATRRGDLNINMTSPMGTKSILLSRRPRDDDSKVGFDKWPFMTTHTWGEDARGTWTLELGFVGSAP-QKGLLKEWTLMLHGTQSAPY--IDQVVRDYQSKLAMSKKQELEEELDE 624          

Query:  445 FLCEYVVCGKI-----VTNQWHVHLHDPATQESANKVAQETGFSVLRNHLNSPNEFVFHHKTVPHVSSVPSWSQHKVLLAHHLVKNAKQVEGFLRRKRGYKPIKKQGRVPLPTINKKGIPGLGESDNIKVDLKLPTDPLFSKEWYIRNTGQADGVKDLDLNVLSAWAQGITGKGVTTAIMDDGIDYLHPDLSKNYNAESSYDFSSNDPYPFPRYTDDWFNSHGTRCAGEISAERDNGICGVGVAYDSKIAGLRMLDQPYMTDLIEAAAMSYDRDNIDIYSASWGPTDDGRTVDGPRNETMRAIVEGVNKGRKGKGSIYVWAS-XXXXXXXXXXXXXXXXSMWTISINSATNDGETASYDESCSSTLASTFSNGKAWFSLDAGVGTVDLYGQCTLHHSGTSAAAPEAAGVFALALEANSNIGWRDMQHLTVLTSKXXXXXXXXXXXXWTINGAGLEFNHLFGYGVLDAGDMVRVA--KKWVNVPERFHCIAGQIDKRYRFNVTKA---LILEIDTDACKSDIGHRVNYLEHVQAFVSVKSSRRGDITMFLTSPMGTTSMILSHRPKDDDSTRGFTKWPFMTTHTWGENPRGKWKLTVMFDTKDPLSQGIFSEWVLVLHGTQSRP 2280
            F C +     +       N+W   +  P  QE+A+ +A+E G+ +L    +  N ++F HK+ P  S   +    K L     V  A+Q      ++R  + ++K                          L L  DP+++++WY+++T     +  LDL+V+  W +GITGKGV   ++DDG+++ H D+  NY+ E+SYDF+ ND  PFPRY     N HGTRCAGEI+ + +N  CGVGVAY+SK+ G+RMLD   +TD IEA+++ ++  ++DIYSASWGP DDG+TV+GP     +A   GV +GR+GKGSI+VWAS   G   D+C+CDGY  S++TISI+SA+  G +  Y E CSSTLA+++S+G      D  + + DL+  CT  H+GTSA+AP AAG+FALALEAN N+ WRDMQHL V TS+            W  NGAGL  N  FG+G+L+A  +V +A  + W NVPE+  C+    D  +     KA   +I+EI T AC+    + +  LEHVQ   +++ SRRGD+ + LTS +GT++++L+ R + D S  GF  W FM+ HTWGENP G W L +   +    ++G    W L+LHGT S+P
Sbjct:   15 FFCVWCALNSVKAKRQFVNEWAAEI--PGGQEAASAIAEELGYDLLGQIGSLENHYLFKHKSHPRRSRRSALHITKRLSDDDRVTWAEQQ---YEKERSKRSVQKDSA-----------------------LDLFNDPMWNQQWYLQDTRMTAALPKLDLHVIPVWEKGITGKGVVITVLDDGLEWNHTDIYANYDPEASYDFNDNDHDPFPRYDLTNENKHGTRCAGEIAMQANNHKCGVGVAYNSKVGGIRMLDG-IVTDAIEASSIGFNPGHVDIYSASWGPNDDGKTVEGPGRLAQKAFEYGVKQGRQGKGSIFVWASGNGGRQGDNCDCDGYTDSIYTISISSASQQGLSPWYAEKCSSTLATSYSSGDY---TDQRITSADLHNDCTETHTGTSASAPLAAGIFALALEANPNLTWRDMQHLVVWTSE---YDPLASNPGWKKNGAGLMVNSRFGFGLLNAKALVDLADPRTWRNVPEKKECVVK--DNNFEPRALKANGEVIVEIPTRACEGQ-ENAIKSLEHVQFEATIEYSRRGDLHVTLTSAVGTSTVLLAERER-DTSPNGFKNWDFMSVHTWGENPVGTWTLKITDMSGRMQNEGRIVNWKLILHGTSSQP 598          

Query:  472 KIVTNQWHVHLHDPATQESANKVAQETGFSVLRNHLNSPNEFVFHHKTVPHVSSVPSWSQHKVLLAHHLVKNAKQVEGFLRRKRGYKPIKKQGRVPLPTINKKGIPGLGESDNIKVDLKLPTDPLFSKEWYIRNTGQADGVKDLDLNVLSAWAQGITGKGVTTAIMDDGIDYLHPDLSKNYNAESSYDFSSNDPYPFPRYTDDWFNSHGTRCAGEISAERDNGICGVGVAYDSKIAGLRMLDQPYMTDLIEAAAMSYDRDNIDIYSASWGPTDDGRTVDGPRNETMRAIVEGVNKGRKGKGSIYVWASXXXXXXX-XXXXXXXXXSMWTISINSATNDGETASYDESCSSTLASTFSNGKAWFSLDAGVGTVDLYGQCTLHHSGTSAAAPEAAGVFALALEANSNIGWRDMQHLTVLTSKXXXXXXXXXXXXWTINGAGLEFNHLFGYGVLDAGDMVRVAKKWVNVPERFHCIAGQI----DKRYRFNVTKALILEIDTDACKSDIGHRVNYLEHVQAFVSVKSSRRGDITMFLTSPMGTTSMILSHRPKDDDSTRGFTKWPFMTTHTWGENPRGKWKLTVMFDTKDPLSQGIFSEWVLVLHGT 2268
            KI TN W VH+  P     A++VAQ+ GF  L       + + F H+ V   S  P   +H  L     VK  +Q     R KR                                  + PTDP F ++WY+       GV   DLNV  AWAQG TG G+  +I+DDGI+  HPDL+ NY+  +S+D +  DP P PRYT    N HGTRCAGE++A  +NG+CGVGVAY+++I G+RMLD   +TD +EA ++  + ++I IYSASWGP DDG+TVDGP      A   GV++GR G GSI+VWASG+GG     CNCDGY  S++T+SI+SAT  G    Y E+CSSTLA+T+S+G      +  + T DL  +CT  H+GTSA+AP AAG+ AL LEAN N+ WRDMQHL V TSK           +W  NG G + +H +GYG+LDAG MV +A+ W  V  +  CI   +    D   R  V KA+       AC  +  H +  LEHVQA +++  +RRGD+ + L SPMGT S +L+ RP  D S  GF  W FMTTH+W E+P G+W L +  +T +  + G  +++ LVL+GT
Sbjct:   28 KIFTNTWAVHI--PGGPAVADRVAQKHGFHNLGQIFG--DYYHFWHRAVTKRSLSPHRPRHSRLQREPQVKWLEQQVAKRRAKRDV-------------------------------YQEPTDPKFPQQWYL------SGVTQRDLNVKEAWAQGFTGHGIVVSILDDGIEKNHPDLAGNYDPGASFDVNDQDPDPQPRYTQMNDNRHGTRCAGEVAAVANNGVCGVGVAYNARIGGVRMLDG-EVTDAVEARSLGLNPNHIHIYSASWGPEDDGKTVDGPARLAEEAFFRGVSQGRGGLGSIFVWASGNGGREHDSCNCDGYTNSIYTLSISSATQFGNVPWYSEACSSTLATTYSSGN---QNEKQIVTTDLRQKCTESHTGTSASAPLAAGIIALTLEANKNLTWRDMQHLVVQTSK----PAHLNADDWATNGVGRKVSHSYGYGLLDAGAMVALAQNWTTVAPQRKCIVEILVEPKDIGKRLEVRKAVT------ACLGEPNH-ITRLEHVQARLTLSYNRRGDLAIHLISPMGTRSTLLAARPH-DYSADGFNDWAFMTTHSWDEDPAGEWVLEIE-NTSEANNYGTLTKFTLVLYGT 573          

Query:  472 KIVTNQWHVHLHDPATQESANKVAQETGFSVLRNHLNSPNEFVFHHKTVPHVSSVPSWSQHKVLLAHHLVKNAKQVEGFLRRKRGYKPIKKQGRVPLPTINKKGIPGLGESDNIKVDLKLPTDPLFSKEWYIRNTGQADGVKDLDLNVLSAWAQGITGKGVTTAIMDDGIDYLHPDLSKNYNAESSYDFSSNDPYPFPRYTDDWFNSHGTRCAGEISAERDNGICGVGVAYDSKIAGLRMLDQPYMTDLIEAAAMSYDRDNIDIYSASWGPTDDGRTVDGPRNETMRAIVEGVNKGRKGKGSIYVWASXXXXXXX-XXXXXXXXXSMWTISINSATNDGETASYDESCSSTLASTFSNGKAWFSLDAGVGTVDLYGQCTLHHSGTSAAAPEAAGVFALALEANSNIGWRDMQHLTVLTSKXXXXXXXXXXXXWTINGAGLEFNHLFGYGVLDAGDMVRVAKKWVNVPERFHCIAGQI----DKRYRFNVTKALILEIDTDACKSDIGHRVNYLEHVQAFVSVKSSRRGDITMFLTSPMGTTSMILSHRPKDDDSTRGFTKWPFMTTHTWGENPRGKWKLTVMFDTKDPLSQGIFSEWVLVLHGT 2268
            KI TN W VH+  P     A++VAQ+ GF  L       + + F H+ V   S  P   +H  L     VK  +Q     R KR                                  + PTDP F ++WY+       GV   DLNV  AWAQG TG G+  +I+DDGI+  HPDL+ NY+  +S+D +  DP P PRYT    N HGTRCAGE++A  +NG+CGVGVAY+++I G+RMLD   +TD +EA ++  + ++I IYSASWGP DDG+TVDGP      A   GV++GR G GSI+VWASG+GG     CNCDGY  S++T+SI+SAT  G    Y E+CSSTLA+T+S+G      +  + T DL  +CT  H+GTSA+AP AAG+ AL LEAN N+ WRDMQHL V TSK           +W  NG G + +H +GYG+LDAG MV +A+ W  V  +  CI   +    D   R  V KA+       AC  +  H +  LEHVQA +++  +RRGD+ + L SPMGT S +L+ RP  D S  GF  W FMTTH+W E+P G+W L +  +T +  + G  +++ LVL+GT
Sbjct:   28 KIFTNTWAVHI--PGGPAVADRVAQKHGFHNLGQIFG--DYYHFWHRAVTKRSLSPHRPRHSRLQREPQVKWLEQQVAKRRAKRDV-------------------------------YQEPTDPKFPQQWYL------SGVTQRDLNVKEAWAQGFTGHGIVVSILDDGIEKNHPDLAGNYDPGASFDVNDQDPDPQPRYTQMNDNRHGTRCAGEVAAVANNGVCGVGVAYNARIGGVRMLDG-EVTDAVEARSLGLNPNHIHIYSASWGPEDDGKTVDGPARLAEEAFFRGVSQGRGGLGSIFVWASGNGGREHDSCNCDGYTNSIYTLSISSATQFGNVPWYSEACSSTLATTYSSGN---QNEKQIVTTDLRQKCTESHTGTSASAPLAAGIIALTLEANKNLTWRDMQHLVVQTSK----PAHLNADDWATNGVGRKVSHSYGYGLLDAGAMVALAQNWTTVAPQRKCIVEILVEPKDIGKRLEVRKAVT------ACLGEPNH-ITRLEHVQARLTLSYNRRGDLAIHLISPMGTRSTLLAARPH-DYSADGFNDWAFMTTHSWDEDPAGEWVLEIE-NTSEANNYGTLTKFTLVLYGT 573          

Query:  472 KIVTNQWHVHLHDPATQESANKVAQETGFSVLRNHLNSPNEFVFHHKTVPHVSSVPSWSQHKVLLAHHLVKNAKQVEGFLRRKRGYKPIKKQGRVPLPTINKKGIPGLGESDNIKVDLKLPTDPLFSKEWYIRNTGQADGVKDLDLNVLSAWAQGITGKGVTTAIMDDGIDYLHPDLSKNYNAESSYDFSSNDPYPFPRYTDDWFNSHGTRCAGEISAERDNGICGVGVAYDSKIAGLRMLDQPYMTDLIEAAAMSYDRDNIDIYSASWGPTDDGRTVDGPRNETMRAIVEGVNKGRKGKGSIYVWASXXXXXXX-XXXXXXXXXSMWTISINSATNDGETASYDESCSSTLASTFSNGKAWFSLDAGVGTVDLYGQCTLHHSGTSAAAPEAAGVFALALEANSNIGWRDMQHLTVLTSKXXXXXXXXXXXXWTINGAGLEFNHLFGYGVLDAGDMVRVAKKWVNVPERFHCIAGQI----DKRYRFNVTKALILEIDTDACKSDIGHRVNYLEHVQAFVSVKSSRRGDITMFLTSPMGTTSMILSHRPKDDDSTRGFTKWPFMTTHTWGENPRGKWKLTVMFDTKDPLSQGIFSEWVLVLHGT 2268
            KI TN W VH+  P     A++VAQ+ GF  L       + + F H+ V   S  P   +H  L     VK  +Q     R KR                                  + PTDP F ++WY+       GV   DLNV  AWAQG TG G+  +I+DDGI+  HPDL+ NY+  +S+D +  DP P PRYT    N HGTRCAGE++A  +NG+CGVGVAY+++I G+RMLD   +TD +EA ++  + ++I IYSASWGP DDG+TVDGP      A   GV++GR G GSI+VWASG+GG     CNCDGY  S++T+SI+SAT  G    Y E+CSSTLA+T+S+G      +  + T DL  +CT  H+GTSA+AP AAG+ AL LEAN N+ WRDMQHL V TSK           +W  NG G + +H +GYG+LDAG MV +A+ W  V  +  CI   +    D   R  V KA+       AC  +  H +  LEHVQA +++  +RRGD+ + L SPMGT S +L+ RP  D S  GF  W FMTTH+W E+P G+W L +  +T +  + G  +++ LVL+GT
Sbjct:   28 KIFTNTWAVHI--PGGPAVADRVAQKHGFHNLGQIFG--DYYHFWHRAVTKRSLSPHRPRHSRLQREPQVKWLEQQVAKRRAKRDV-------------------------------YQEPTDPKFPQQWYL------SGVTQRDLNVKEAWAQGFTGHGIVVSILDDGIEKNHPDLAGNYDPGASFDVNDQDPDPQPRYTQMNDNRHGTRCAGEVAAVANNGVCGVGVAYNARIGGVRMLDG-EVTDAVEARSLGLNPNHIHIYSASWGPEDDGKTVDGPARLAEEAFFRGVSQGRGGLGSIFVWASGNGGREHDSCNCDGYTNSIYTLSISSATQFGNVPWYSEACSSTLATTYSSGN---QNEKQIVTTDLRQKCTESHTGTSASAPLAAGIIALTLEANKNLTWRDMQHLVVQTSK----PAHLNADDWATNGVGRKVSHSYGYGLLDAGAMVALAQNWTTVAPQRKCIVEILVEPKDIGKRLEVRKAVT------ACLGEPNH-ITRLEHVQARLTLSYNRRGDLAIHLISPMGTRSTLLAARPH-DYSADGFNDWAFMTTHSWDEDPAGEWVLEIE-NTSEANNYGTLTKFTLVLYGT 573          

Query:  442 LFLCEYVVCGK---IVTNQWHVHLHDPATQESANKVAQETGFSVLRNHLNSPNEFVFHHKTVPHVSSVPSWSQHKVLLAHHLVKNAKQVEGFLRRKRGYKPIKKQGRVPLPTINKKGIPGLGESDNIKVDLKLPTDPLFSKEWYIRNTGQADGVKDLDLNVLSAWAQGITGKGVTTAIMDDGIDYLHPDLSKNYNAESSYDFSSNDPYPFPRYTDDWFNSHGTRCAGEISAERDNGICGVGVAYDSKIAGLRMLDQPYMTDLIEAAAMSYDRDNIDIYSASWGPTDDGRTVDGPRNETMRAIVEGVNKGRKGKGSIYVWASXXXXXXXXXXXXXXXXSMWTISINSATNDGETASYDESCSSTLASTFSNGKAWFSLDAGVGTVDLYGQCTLHHSGTSAAAPEAAGVFALALEANSNIGWRDMQHLTVLTSKXXXXXXXXXXXXWTINGAGLEFNHLFGYGVLDAGDMVRVAKKWVNVPERFHCIAGQIDKRYRFNVTKALILEIDTDACKSDIGHRVNYLEHVQAFVSVKSSRRGDITMFLTSPMGTTSMILSHRPKDDDSTRGFTKWPFMTTHTWGENPRGKWKLTVMFDTKDPLSQGIFSEWVLVLHGTQSRPYDKLSSSLEKIIPKLGVVKRQHASNRFSQ 2367
            L  C  V       + TN + V LH    +E A +VA E GF V R    +   + F+H  +       S    + L     +K A Q EGF R+KRGY+ I +                        +D+ +  DPLF+K+WY+ NTGQADG   LDLNV  AW  G TGKGVT  IMDDGIDYLHPDL+ NYN+++SYDFSSNDPYP+PRYTDDWFNSHGTRCAGE+SA   N ICGVGVAY+SK+AG+RMLDQP+MTD+IEA+++S+    IDIYSASWGPTD+G+TVDGPR  T++A+ +GVNKGR GKGSIYVWASGDGG+ DDCNCDGYA+SMWTISINSA NDG TA YDESCSSTLASTFSNG+   + +AGV T DLYG CTL HSGTSAAAPEAAGVFALALEAN ++ WRDMQHLTVLTSK       D  H W  NG GLEFNHLFGYGVLDAG MV++AK W  VPERFHC+ G +    +   T  L+L + T+AC+    + V YLEHVQA ++V ++RRGD+ + +TSPMGT S++LS RP+DDDS  GF KWPFMTTHTWGE+ RG W L + F    P  +G+  EW L+LHGTQS PY  +   +     KL + K+Q       +
Sbjct:   14 LLFCVMVFASAERPVFTNHFLVELHKDG-EEEARQVAAEHGFGV-RKLPFAEGLYHFYHNGLAKAKRRRSLHHKRQLERDPRIKMALQQEGFDRKKRGYRDINE------------------------IDINM-NDPLFTKQWYLFNTGQADGTPGLDLNVAEAWELGYTGKGVTIGIMDDGIDYLHPDLAYNYNSDASYDFSSNDPYPYPRYTDDWFNSHGTRCAGEVSAAASNNICGVGVAYNSKVAGIRMLDQPFMTDIIEASSISHMPQLIDIYSASWGPTDNGKTVDGPRELTLQAMADGVNKGRGGKGSIYVWASGDGGSYDDCNCDGYASSMWTISINSAINDGRTALYDESCSSTLASTFSNGRK-RNPEAGVATTDLYGNCTLRHSGTSAAAPEAAGVFALALEANVDLTWRDMQHLTVLTSK--RNQLHDEVHQWRRNGVGLEFNHLFGYGVLDAGAMVKMAKDWKTVPERFHCVGGSVQNPEKIPPTGKLVLTLQTNACEGK-ENFVRYLEHVQAVITVNATRRGDLNINMTSPMGTKSILLSRRPRDDDSKVGFDKWPFMTTHTWGEDARGTWTLELGFVGSAP-QKGLLKEWTLMLHGTQSAPY--IDQVVRDYQSKLAMSKKQELEEELDE 624          

Query:  475 IVTNQWHVHLHDPATQESANKVAQETGFSVLRNHLNSPNEFVFHHKTVPHVSSVPSWSQHKVLLAHHLVKNAKQVEGFLRRKRGYKPIKKQGRVPLPTINKKGIPGLGESDNIKVDLKLPTDPLFSKEWYIRNTGQADGVKDLDLNVLSAWAQGITGKGVTTAIMDDGIDYLHPDLSKNYNAESSYDFSSNDPYPFPRYTDDWFNSHGTRCAGEISAERDNGICGVGVAYDSKIAGLRMLDQPYMTDLIEAAAMSYDRDNIDIYSASWGPTDDGRTVDGPRNETMRAIVEGVNKGRKGKGSIYVWASXXXXXXXXXXXXXXXXSMWTISINSATNDGETASYDESCSSTLASTFSNGKAWFSLDAGVGTVDLYGQCTLHHSGTSAAAPEAAGVFALALEANSNIGWRDMQHLTVLTSKXXXXXXXXXXXXWTINGAGLEFNHLFGYGVLDAGDMVRVAKKWVNVPERFHCIAGQIDKRYRFNVTKALILEIDTDACKSDIGHRVNYLEHVQAFVSVKSSRRGDITMFLTSPMGTTSMILSHRPKDDDSTRGFTKWPFMTTHTWGENPRGKWKLTVMFDTKDPLSQGIFSEWVLVLHGTQSRPY 2283
            + TN + V LH     E A +VA E GF V R    +   + F+H  +       S    + L     VK A Q EGF R+KRGY+ I +                        +D+ +  DPLF+K+WY+ NTGQADG   LDLNV  AW  G TGKGVT  IMDDGIDYLHPDL+ NYNAE+SYDFSSNDPYP+PRYTDDWFNSHGTRCAGE+SA  +N ICGVGVAY+SK+AG+RMLDQP+MTD+IEA+++S+    IDIYSASWGPTD+G+TVDGPR  T++A+ +GVNKGR GKGSIYVWASGDGG+ DDCNCDGYA+SMWTISINSA NDG TA YDESCSSTLASTFSNG+   + +AGV T DLYG CTL HSGTSAAAPEAAGVFALALEAN  + WRDMQHLTVLTSK       D  H W  NG GLEFNHLFGYGVLDAG MV++AK W  VPERFHC+ G +    +   T  L+L + TDAC+    + V YLEHVQA ++V ++RRGD+ + +TSPMGT S++LS RP+DDDS  GF KWPFMTTHTWGE+ RG W L + F    P  +G+  EW L+LHGTQS PY
Sbjct:   29 VFTNHFLVELHKGGEDE-ARQVAAEHGFGV-RKLPFAEGLYHFYHNGLAKAKRRRSLHHKQQLERDPRVKMALQQEGFDRKKRGYRDINE------------------------IDINM-NDPLFTKQWYLINTGQADGTPGLDLNVAEAWELGYTGKGVTIGIMDDGIDYLHPDLASNYNAEASYDFSSNDPYPYPRYTDDWFNSHGTRCAGEVSAAANNNICGVGVAYNSKVAGIRMLDQPFMTDIIEASSISHMPQLIDIYSASWGPTDNGKTVDGPRELTLQAMADGVNKGRGGKGSIYVWASGDGGSYDDCNCDGYASSMWTISINSAINDGRTALYDESCSSTLASTFSNGRK-RNPEAGVATTDLYGNCTLRHSGTSAAAPEAAGVFALALEANLGLTWRDMQHLTVLTSK--RNQLHDEVHQWRRNGVGLEFNHLFGYGVLDAGAMVKMAKDWKTVPERFHCVGGSVQDPEKIPSTGKLVLTLTTDACEGK-ENFVRYLEHVQAVITVNATRRGDLNINMTSPMGTKSILLSRRPRDDDSKVGFDKWPFMTTHTWGEDARGTWTLELGFVGSAP-QKGVLKEWTLMLHGTQSAPY 599          

Query:  475 IVTNQWHVHLHDPATQESANKVAQETGFSVLRNHLNSPNEFVFHHKTVPHVSSVPSWSQHKVLLAHHLVKNAKQVEGFLRRKRGYKPIKKQGRVPLPTINKKGIPGLGESDNIKVDLKLPTDPLFSKEWYIRNTGQADGVKDLDLNVLSAWAQGITGKGVTTAIMDDGIDYLHPDLSKNYNAESSYDFSSNDPYPFPRYTDDWFNSHGTRCAGEISAERDNGICGVGVAYDSKIAGLRMLDQPYMTDLIEAAAMSYDRDNIDIYSASWGPTDDGRTVDGPRNETMRAIVEGVNKGRKGKGSIYVWASXXXXXXXXXXXXXXXXSMWTISINSATNDGETASYDESCSSTLASTFSNGKAWFSLDAGVGTVDLYGQCTLHHSGTSAAAPEAAGVFALALEANSNIGWRDMQHLTVLTSKXXXXXXXXXXXXWTINGAGLEFNHLFGYGVLDAGDMVRVAKKWVNVPERFHCIAGQIDKRYRFNVTKALILEIDTDACKSDIGHRVNYLEHVQAFVSVKSSRRGDITMFLTSPMGTTSMILSHRPKDDDSTRGFTKWPFMTTHTWGENPRGKWKLTVMFDTKDPLSQGIFSEWVLVLHGTQSRPY 2283
            + TN + V LH    ++ A +VA E GF V R    +   + F+H  +       S    + L     VK A Q EGF R+KRGY+ I +                        +D+ +  DPLF+K+WY+ NTGQADG   LDLNV  AW  G TGKGVT  IMDDGIDYLHPDL+ NYNAE+SYDFSSNDPYP+PRYTDDWFNSHGTRCAGE+SA  +N ICGVGVAY+SK+AG+RMLDQP+MTD+IEA+++S+    IDIYSASWGPTD+G+TVDGPR  T++A+ +GVNKGR GKGSIYVWASGDGG+ DDCNCDGYA+SMWTISINSA NDG TA YDESCSSTLASTFSNG+   + +AGV T DLYG CTL HSGTSAAAPEAAGVFALALEAN  + WRDMQHLTVLTSK       D  H W  NG GLEFNHLFGYGVLDAG MV++AK W  VPERFHC+ G +    +   T  L+L + TDAC+    + V YLEHVQA ++V ++RRGD+ + +TSPMGT S++LS RP+DDDS  GF KWPFMTTHTWGE+ RG W L + F    P  +G+  EW L+LHGTQS PY
Sbjct:   29 VFTNHFLVELH-KGGEDKARQVAAEHGFGV-RKLPFAEGLYHFYHNGLAKAKRRRSLHHKQQLERDPRVKMALQQEGFDRKKRGYRDINE------------------------IDINM-NDPLFTKQWYLINTGQADGTPGLDLNVAEAWELGYTGKGVTIGIMDDGIDYLHPDLASNYNAEASYDFSSNDPYPYPRYTDDWFNSHGTRCAGEVSAAANNNICGVGVAYNSKVAGIRMLDQPFMTDIIEASSISHMPQLIDIYSASWGPTDNGKTVDGPRELTLQAMADGVNKGRGGKGSIYVWASGDGGSYDDCNCDGYASSMWTISINSAINDGRTALYDESCSSTLASTFSNGRK-RNPEAGVATTDLYGNCTLRHSGTSAAAPEAAGVFALALEANLGLTWRDMQHLTVLTSK--RNQLHDEVHQWRRNGVGLEFNHLFGYGVLDAGAMVKMAKDWKTVPERFHCVGGSVQDPEKIPSTGKLVLTLTTDACEGK-ENFVRYLEHVQAVITVNATRRGDLNINMTSPMGTKSILLSRRPRDDDSKVGFDKWPFMTTHTWGEDARGTWTLELGFVGSAP-QKGVLKEWTLMLHGTQSAPY 599          

Query:  427 ITWILLFLCEYVVCGKIV---TNQWHVHLHDPATQESANKVAQETGFSVLRNHLNSPNEFVFHHKTVPHVSSVPSWSQHKVLLAHHLVKNAKQVEGFLRRKRGYKPIKKQGRVPLPTINKKGIPGLGESDNIKVDLKLPTDPLFSKEWYIRNTGQADGVKDLDLNVLSAWAQGITGKGVTTAIMDDGIDYLHPDLSKNYNAESSYDFSSNDPYPFPRYTDDWFNSHGTRCAGEISAERDNGICGVGVAYDSKIAGLRMLDQPYMTDLIEAAAMSYDRDNIDIYSASWGPTDDGRTVDGPRNETMRAIVEGVNKGRKGKGSIYVWASXXXXXXXXXXXXXXXXSMWTISINSATNDGETASYDESCSSTLASTFSNGKAWFSLDAGVGTVDLYGQCTLHHSGTSAAAPEAAGVFALALEANSNIGWRDMQHLTVLTSKXXX--------------------XXXXXXXXXWTINGAGLEFNHLFGYGVLDAGDMVRVAKKWVNVPERFHCIAGQIDKRYRFNVTKALILEIDTDACKSDIGHRVNYLEHVQAFVSVKSSRRGDITMFLTSPMGTTSMILSHRPKDDDSTRGFTKWPFMTTHTWGENPRGKWKLTVMFDTKDPLSQGIFSEWVLVLHGTQSRPYDKLSSSLEKIIPKLGVVKRQH 2346
            +  I +FL  ++  G+ V   TN +HVHL +    E A+++A+  GF        S NE+ F    + H  +  S   H  L     V + +Q++G+ R KRGY+P++++                 ES      +  P+DPL+  +WY++NTGQA G   LDLNV  AWA G TGK +TTAIMDDG+DY+HPD+  N+NAE+SYDFSSNDP+P+PRYTDDWFNSHGTRCAGEI A RDNG+CGVGVAYD K+AG+RMLDQPYMTDLIEA +M ++   I IYSASWGPTDDG+TVDGPRN TMRAIV GVN+GR G GSI+VWASGDGG  DDCNCDGYAASMWTISINSA N+GE A YDESCSSTLASTFSNG    + + GV T DLYG+CT  HSGTSAAAPEAAGVFALALEAN ++ WRD+QHLTVLTS RN                      H       W +NG GLE+NHLFG+GVLDA +MV +A  W   P R+HC AG ID  +       LILEI+TD C       V YLEHVQA VS  S+RRGD T++L SPMGT +MILS RPKDDDS  GFT WPFMTTHTWGENP GKW+L   F      + G   ++ L+LHGT+  PY+ +   + +   KL  V++ H
Sbjct:    6 VDLICVFLSIFIGIGEAVDVYTNHFHVHLKEGGGLEDAHRIAKRHGFINRGQVAASDNEYHFVQPALVHARTRRSAGHHAKLHNDDEVLHVEQLKGYTRTKRGYRPLEQRL----------------ESQFDFSAVMSPSDPLYGYQWYLKNTGQAGGKARLDLNVERAWAMGFTGKNITTAIMDDGVDYMHPDIKNNFNAEASYDFSSNDPFPYPRYTDDWFNSHGTRCAGEIVAARDNGVCGVGVAYDGKVAGIRMLDQPYMTDLIEANSMGHEPSKIHIYSASWGPTDDGKTVDGPRNATMRAIVRGVNEGRNGLGSIFVWASGDGGEDDDCNCDGYAASMWTISINSAINNGENAHYDESCSSTLASTFSNGGR--NPETGVATTDLYGRCTRSHSGTSAAAPEAAGVFALALEANPSLTWRDLQHLTVLTSSRNSLFDGRCRDFPSLGINDNHRDSHGNCSHFEWQMNGVGLEYNHLFGFGVLDAAEMVMLAMAWKTSPPRYHCTAGLIDTPHEIPADGNLILEINTDGCAGS-QFEVRYLEHVQAVVSFNSTRRGDTTLYLISPMGTRTMILSRRPKDDDSKDGFTNWPFMTTHTWGENPTGKWRLVARFQGPGAHA-GTLKKFELMLHGTREAPYNLIEPIVGQTNKKLDTVQKAH 648          

Query:  475 IVTNQWHVHLHDPATQESANKVAQETGFSVLRNHLNSPNEFVFHHKTVPHVSSVPSWSQHKVLLAHHLVKNAKQVEGFLRRKRGYKPIKKQGRVPLPTINKKGIPGLGESDNIKVDLKLPTDPLFSKEWYIRNTGQADGVKDLDLNVLSAWAQGITGKGVTTAIMDDGIDYLHPDLSKNYNAESSYDFSSNDPYPFPRYTDDWFNSHGTRCAGEISAERDNGICGVGVAYDSKIAGLRMLDQPYMTDLIEAAAMSYDRDNIDIYSASWGPTDDGRTVDGPRNETMRAIVEGVNKGRKGKGSIYVWASXXXXXXXXXXXXXXXXSMWTISINSATNDGETASYDESCSSTLASTFSNGKAWFSLDAGVGTVDLYGQCTLHHSGTSAAAPEAAGVFALALEANSNIGWRDMQHLTVLTSKXXXXXXXXXXXXWTINGAGLEFNHLFGYGVLDAGDMVRVAKKWVNVPERFHCIAGQIDKRYRFNVTKALILEIDTDACKSDIGHRVNYLEHVQAFVSVKSSRRGDITMFLTSPMGTTSMILSHRPKDDDSTRGFTKWPFMTTHTWGENPRGKWKLTVMFDTKDPLSQGIFSEWVLVLHGTQSRPYDKLSSSLEKIIPKLGVVKRQHASNRFSQ 2367
            + TN + V LH    +E A +VA E GF V R    +   + F+H  +       S    + L     +K A Q EGF R+KRGY+ I +                        +D+ +  DPLF+K+WY+ NTGQADG   LDLNV  AW  G TGKGVT  IMDDGIDYLHPDL+ NYNA++SYDFSSNDPYP+PRYTDDWFNSHGTRCAGE+SA   N ICGVGVAY+SK+AG+RMLDQP+MTD+IEA+++S+    IDIYSASWGPTD+G+TVDGPR  T++A+ +GVNKGR GKGSIYVWASGDGG+ DDCNCDGYA+SMWTISINSA NDG TA YDESCSSTLASTFSNG+   + +AGV T DLYG CTL HSGTSAAAPEAAGVFALALEAN ++ WRDMQHLTVLTSK       D  H W  NG GLEFNHLFGYGVLDAG MV++AK W  VPERFHC+ G +    +   T  L+L + T+AC+    + V YLEHVQA ++V ++RRGD+ + +TSPMGT S++LS RP+DDDS  GF KWPFMTTHTWGE+ RG W L + F    P  +G+  EW L+LHGTQS PY  +   +     KL + K+Q       +
Sbjct:   28 VFTNHFLVELHKDG-EEEARQVAAEHGFGV-RKLPFAEGLYHFYHNGLAKAKRRRSLHHKRQLERDPRIKMALQQEGFDRKKRGYRDINE------------------------IDINM-NDPLFTKQWYLFNTGQADGTPGLDLNVAEAWELGYTGKGVTIGIMDDGIDYLHPDLAYNYNADASYDFSSNDPYPYPRYTDDWFNSHGTRCAGEVSAAASNNICGVGVAYNSKVAGIRMLDQPFMTDIIEASSISHMPQLIDIYSASWGPTDNGKTVDGPRELTLQAMADGVNKGRGGKGSIYVWASGDGGSYDDCNCDGYASSMWTISINSAINDGRTALYDESCSSTLASTFSNGRK-RNPEAGVATTDLYGNCTLRHSGTSAAAPEAAGVFALALEANLDLTWRDMQHLTVLTSK--RNQLHDEVHQWRRNGVGLEFNHLFGYGVLDAGAMVKMAKDWKTVPERFHCVGGSVQNPEKIPPTGKLVLTLKTNACEGK-ENFVRYLEHVQAVITVNATRRGDLNINMTSPMGTKSILLSRRPRDDDSKVGFDKWPFMTTHTWGEDARGTWTLELGFVGSAP-QKGLLKEWTLMLHGTQSAPY--IDQVVRDYQSKLAMSKKQELEEELDE 624          

Query:  421 MKITWILLFLCEYVVCGKIVTNQWHVHLHDPATQESANKVAQETGFSVLRNHLNSPNEFVFHHKTVPHVSSVPSWSQHKVLLAHHLVKNAKQVEGFLRRKRGYKPIKKQGRVPLPTINKKGIPGLGESDNIKVDLKLPTDPLFSKEWYIRNTGQADGVKDLDLNVLSAWAQGITGKGVTTAIMDDGIDYLHPDLSKNYNAESSYDFSSNDPYPFPRYTDDWFNSHGTRCAGEISAERDNGICGVGVAYDSKIAGLRMLDQPYMTDLIEAAAMSYDRDNIDIYSASWGPTDDGRTVDGPRNETMRAIVEGVNKGRKGKGSIYVWASXXXXXXXXXXXXXXXXSMWTISINSATNDGETASYDESCSSTLASTFSNGKAWFSLDAGVGTVDLYGQCTLHHSGTSAAAPEAAGVFALALEANSNIGWRDMQHLTVLTSKXXXXXXXXXXXXWTINGAGLEFNHLFGYGVLDAGDMVRVAKKWVNVPERFHCIAGQIDKRYRFNVTKALILEIDTDACKSDIGHRVNYLEHVQAFVSVKSSRRGDITMFLTSPMGTTSMILSHRPKDDDSTRGFTKWPFMTTHTWGENPRGKWKLTVMFDTKDPLSQGIFSEWVLVLHGTQSRPYDKLSSSLEKIIPKLGVVKRQHASNRFSQ 2367
            MKITWILLFLCEYVVCGKIVTNQWHVHLHDPATQESANKVAQETGFSVLRNHLNSPNEFVFHHKTVPHVSSVPSWSQHKVLLAHHLVKNAKQVEGFLRRKRGYKPIKKQGRVPLPTINKKGIPGLGESDNIKVDLKLPTDPLFSKEWYIRNTGQADGVKDLDLNVLSAWAQGITGKGVTTAIMDDGIDYLHPDLSKNYNAESSYDFSSNDPYPFPRYTDDWFNSHGTRCAGEISAERDNGICGVGVAYDSKIAGLRMLDQPYMTDLIEAAAMSYDRDNIDIYSASWGPTDDGRTVDGPRNETMRAIVEGVNKGRKGKGSIYVWASGDGGAADDCNCDGYAASMWTISINSATNDGETASYDESCSSTLASTFSNGKAWFSLDAGVGTVDLYGQCTLHHSGTSAAAPEAAGVFALALEANSNIGWRDMQHLTVLTSKRNHLHDRDRRHNWTINGAGLEFNHLFGYGVLDAGDMVRVAKKWVNVPERFHCIAGQIDKRYRFNVTKALILEIDTDACKSDIGHRVNYLEHVQAFVSVKSSRRGDITMFLTSPMGTTSMILSHRPKDDDSTRGFTKWPFMTTHTWGENPRGKWKLTVMFDTKDPLSQGIFSEWVLVLHGTQSRPYDKLSSSLEKIIPKLGVVKRQHASNRFSQ
Sbjct:    1 MKITWILLFLCEYVVCGKIVTNQWHVHLHDPATQESANKVAQETGFSVLRNHLNSPNEFVFHHKTVPHVSSVPSWSQHKVLLAHHLVKNAKQVEGFLRRKRGYKPIKKQGRVPLPTINKKGIPGLGESDNIKVDLKLPTDPLFSKEWYIRNTGQADGVKDLDLNVLSAWAQGITGKGVTTAIMDDGIDYLHPDLSKNYNAESSYDFSSNDPYPFPRYTDDWFNSHGTRCAGEISAERDNGICGVGVAYDSKIAGLRMLDQPYMTDLIEAAAMSYDRDNIDIYSASWGPTDDGRTVDGPRNETMRAIVEGVNKGRKGKGSIYVWASGDGGAADDCNCDGYAASMWTISINSATNDGETASYDESCSSTLASTFSNGKAWFSLDAGVGTVDLYGQCTLHHSGTSAAAPEAAGVFALALEANSNIGWRDMQHLTVLTSKRNHLHDRDRRHNWTINGAGLEFNHLFGYGVLDAGDMVRVAKKWVNVPERFHCIAGQIDKRYRFNVTKALILEIDTDACKSDIGHRVNYLEHVQAFVSVKSSRRGDITMFLTSPMGTTSMILSHRPKDDDSTRGFTKWPFMTTHTWGENPRGKWKLTVMFDTKDPLSQGIFSEWVLVLHGTQSRPYDKLSSSLEKIIPKLGVVKRQHASNRFSQ 649          

Query:  436 ILLFLCEYVVCG------KIVTNQWHVHLHDPATQESANKVAQETGFSVLRNHLNSPNEFVFHHKTVPHVSSVPSWSQH-KVLLAHHLVKNAKQVEGFLRRKRGYKPIKK-QGRVPLPTINKKGIPGLGESDNIKVDLKLPTDPLFSKEWYIRNTGQADGVKDLDLNVLSAWAQGITGKGVTTAIMDDGIDYLHPDLSKNYNAESSYDFSSNDPYPFPRYTDDWFNSHGTRCAGEISAERDNGICGVGVAYDSKIAGLRMLDQPYMTDLIEAAAMSYDRDNIDIYSASWGPTDDGRTVDGPRNETMRAIVEGVNKGRKGKGSIYVWASXXXXXXXXXXXXXXXXSMWTISINSATNDGETASYDESCSSTLASTFSNGKAWFSLDAGVGTVDLYGQCTLHHSGTSAAAPEAAGVFALALEANSNIGWRDMQHLTVLTSKXXXXXXXXXXXXWTINGAGLEFNHLFGYGVLDAGDMVRVAKKWVNVPERFHCIAGQIDKRYRFNVTKALILEIDTDACKSDIGHRVNYLEHVQAFVSVKSSRRGDITMFLTSPMGTTSMILSHRPKDDDSTRGFTKWPFMTTHTWGENPRGKWKLTVMFDTKDPLSQGIFSEWVLVLHGTQSRPYDKLSSSLEKIIPKLGVVKRQHASNRFSQ 2367
            ILL  C  V+         + TN +HV L     +E A +VA++TG  ++R HL    EF + H  VP   SV   S+H + +  H  V    Q+EGF R KRG+KP K  Q R       K+       SD        PTDP+F KEWYI+NTGQA G   LDLNVL AW +G+TG GVTTAIMDDGIDY+HPDL+ NYN E+SYDFSSNDPYP+PRYTDDWFNSHGTRCAGEIS++RDNGICGVGVAY SKIAGLRMLDQPYMTDLIEAAAMSY RD IDIYSASWGPTDDG+TVDGPRNETMRAIVEGVNKGR GKGSI+VWASGDGG  DDCNCDGYAASMWTISINSATNDGETA YDESCSSTLASTFSNGKA  +LDAGV TVDLYG+CTLHHSGTSAAAPEAAGVFALALEANSN+ WRDMQHL VLTSKRNHL+D + +H+WT+N AGLEFNHLFGYGVLDAGD+V+ A+ W  VPERFHCIAG++ + Y FNV  A+ +EIDTDACK D  HR+NY+EHVQAF+++KS+RRGD+T+FLT+P GTTS+ILS RPKD DS  GFT WPFMTTH WGE+PRGKWKL V  D  D    G+ SEWVLV+HGTQ +PY KL S L     K+ V+K+ H    +++
Sbjct:    7 ILLGWCLLVIAAVTSSKESLFTNHFHVTLKS-GNEEVAKRVARDTGLRLVRRHLGKDTEFHYVHDQVPEADSV--LSRHLRSIADHEDVTRVVQLEGFKRVKRGFKPAKATQSR------QKRS----ASSDE-------PTDPMFKKEWYIKNTGQAGGYPGLDLNVLPAWKEGVTGNGVTTAIMDDGIDYMHPDLAHNYNMEASYDFSSNDPYPYPRYTDDWFNSHGTRCAGEISSKRDNGICGVGVAYGSKIAGLRMLDQPYMTDLIEAAAMSYKRDIIDIYSASWGPTDDGKTVDGPRNETMRAIVEGVNKGRNGKGSIFVWASGDGGPDDDCNCDGYAASMWTISINSATNDGETALYDESCSSTLASTFSNGKA-STLDAGVATVDLYGKCTLHHSGTSAAAPEAAGVFALALEANSNLTWRDMQHLVVLTSKRNHLYDPNGKHDWTVNSAGLEFNHLFGYGVLDAGDIVKTARDWKTVPERFHCIAGEVKRLYHFNVQNAIEMEIDTDACKDDPKHRINYIEHVQAFITLKSTRRGDVTVFLTAPTGTTSLILSKRPKDADSKVGFTSWPFMTTHMWGESPRGKWKLKVALDATDASVHGVISEWVLVIHGTQEQPYKKLRSGLSS---KIDVIKKIHEKKSYTE 634          

Query:  469 GKIVTNQWHVHLHDPAT-----QESANKVAQETGFSVLRNH-LNSPNEFVFHHKTVPHVSSVPSWSQHKVLLAHHLVKNAKQVEGFLRRKRGYKPIKKQGRVPLPTINKKGIPGLGESDNIKVDLKLPTDPLFSKEWYIRNTGQADGVKDLDLNVLSAWAQGITGKGVTTAIMDDGIDYLHPDLSKNYNAESSYDFSSNDPYPFPRYTDDWFNSHGTRCAGEISAERDNGICGVGVAYDSKIAGLRMLDQPYMTDLIEAAAMSYDRDNIDIYSASWGPTDDGRTVDGPRNETMRAIVEGVNKGRKGKGSIYVWASXXXXXXXXXXXXXXXXSMWTISINSATNDGETASYDESCSSTLASTFSNGKAWFSLDAGVGTVDLYGQCTLHHSGTSAAAPEAAGVFALALEANSNIGWRDMQHLTVLTSKXXXXXXXXXXXXWTINGAGLEFNHLFGYGVLDAGDMVRVAKKWVNVPERFHCIAGQIDKRYRFNVTKALILEIDTDACKSDIGHRVNYLEHVQAFVSVKSSRRGDITMFLTSPMGTTSMILSHRPKDDDSTRGFTKWPFMTTHTWGENPRGKWKLTVMFD--TKDPLSQGIFSEWVLVLHGTQSRPYDKLSSSLEKIIPKLGVVKRQHASNRFS 2364
            GKI TNQW V L          + SAN++A+E GF  L  H    PNEFVF H  +P+    PS+  +  L  H  + NA Q+EGF+RRKRGY+P+       L  IN      L + +    +L+  TDPLF  EWY+ N GQADGV  LDLNVL+AW+Q ITG+GV TAIMDDG+DYLHPD++ NY AE+SYDFSSND +P+PRYTDDWFNSHGTRCAGE++A   NG+CGVGVA  SK+AGLRMLDQPYMTDLIEAAAM+Y RD IDIYSASWGPTDDG TVDGPRN+TMRA+V+GVNKGRKGKGS+YVWASGDGG  DDCNCDGYAASMWTISINS TNDG TA YDESC+STLASTFSNGK+ F  DAGVGT+DLYG CTLHHSGTSAAAPEAAGVFALALEA + + WRD+QHLTVLTSKRNHL+DR   HNWTINGAGLEFNHLFG+GVLDAGDMV +AKKW  VPERFHC+AG  + R    + + + LE+DTDAC ++  ++VNYLEHVQAF+++K++RRGDIT+FLTSPM TTSM+L  RPKD D+TRGFTKWPFMTTH W ENPRGKW LT+  D  +KDPL  GI +EW+LV+HGTQ  PY  LS S   I PKLG+VK+QH + RF+
Sbjct:   19 GKIHTNQWLVKLKHNGNDRDELKRSANEIARELGFITLNEHNYGEPNEFVFTHIGLPYARGTPSYIHNHRLNKHPSIDNAIQIEGFVRRKRGYRPLTDDN---LSRINIPKARVLTDKEKELSELRSKTDPLFESEWYLHNIGQADGVPGLDLNVLAAWSQNITGRGVITAIMDDGVDYLHPDIAGNYAAEASYDFSSNDAFPYPRYTDDWFNSHGTRCAGEVAAIAGNGVCGVGVAPGSKVAGLRMLDQPYMTDLIEAAAMAYARDLIDIYSASWGPTDDGTTVDGPRNQTMRALVDGVNKGRKGKGSLYVWASGDGGENDDCNCDGYAASMWTISINSVTNDGHTAVYDESCASTLASTFSNGKSPFLRDAGVGTIDLYGNCTLHHSGTSAAAPEAAGVFALALEAQNELTWRDIQHLTVLTSKRNHLYDRQHNHNWTINGAGLEFNHLFGFGVLDAGDMVHLAKKWKTVPERFHCVAGTFNGRKIARLGQPIFLELDTDACMNNPINQVNYLEHVQAFITIKATRRGDITLFLTSPMNTTSMLLRRRPKDADNTRGFTKWPFMTTHMWSENPRGKWLLTIGLDSNSKDPLGYGILTEWILVIHGTQQPPYAHLSDSTINIAPKLGIVKKQHETKRFN 655          

Query:  436 ILLFLCEYVVCGKIVTNQWHVHLHDPAT-----QESANKVAQETGFSVLRNH-LNSPNEFVFHHKTVPHVSSVPSWSQHKVLLAHHLVKNAKQVEGFLRRKRGYKPIKKQGRVPLPTINKKGIPGLGESDNIKVDLKLPTDPLFSKEWYIRNTGQADGVKDLDLNVLSAWAQGITGKGVTTAIMDDGIDYLHPDLSKNYNAESSYDFSSNDPYPFPRYTDDWFNSHGTRCAGEISAERDNGICGVGVAYDSKIAGLRMLDQPYMTDLIEAAAMSYDRDNIDIYSASWGPTDDGRTVDGPRNETMRAIVEGVNKGRKGKGSIYVWASXXXXXXXXXXXXXXXXSMWTISINSATNDGETASYDESCSSTLASTFSNGKAWFSLDAGVGTVDLYGQCTLHHSGTSAAAPEAAGVFALALEANSNIGWRDMQHLTVLTSKXXXXXXXXXXXXWTINGAGLEFNHLFGYGVLDAGDMVRVAKKWVNVPERFHCIAGQIDKRYRFNVTKALILEIDTDACKSDIGHRVNYLEHVQAFVSVKSSRRGDITMFLTSPMGTTSMILSHRPKDDDSTRGFTKWPFMTTHTWGENPRGKWKLTVMFD--TKDPLSQGIFSEWVLVLHGTQSRPYDKLSSSLEKIIPKLGVVKRQHASNRFS 2364
            I+  +   +  GKI TNQW V L          + SAN++A+E GF  L  H    PNEFVF H  +P+    PS+  +  L  H  + NA Q+EGF+RRKRGY+P+       L  IN      L + +    +L+  TDPLF  EWY+ N GQADGV  LDLNVL+AW+Q ITG+GV TAIMDDG+DYLHPD++ NY AE+SYDFSSND +P+PRYTDDWFNSHGTRCAGE++A   NG+CGVGVA  SK+AGLRMLDQPYMTDLIEAAAM+Y RD IDIYSASWGPTDDG TVDGPRN+TMRA+V+GVNKGRKGKGS+YVWASGDGG  DDCNCDGYAASMWTISINS TNDG TA YDESC+STLASTFSNGK+ F  DAGVGT+DLYG CTLHHSGTSAAAPEAAGVFALALEA + + WRD+QHLTVLTSKRNHL+DR   HNWTINGAGLEFNHLFG+GVLDAGDMV +AKKW  VPERFHC+AG  + R    + + + LE+DTDAC ++  ++VNYLEHVQAF+++K++RRGDIT+FLTSPM TTSM+L  RPKD D+TRGFTKWPFMTTH W ENPRGKW LT+  D  +KDPL   I +EW+LV+HGTQ  PY  LS S   I PKLG+VK+QH + RF+
Sbjct:    8 IIYHIITQISYGKIHTNQWLVKLKHNGNDRDELKRSANEIARELGFITLNEHNYGEPNEFVFTHIGLPYARGTPSYIHNHRLNKHPSIDNAIQIEGFVRRKRGYRPLTDDN---LSRINIPKARVLTDKEKELSELRSKTDPLFESEWYLHNIGQADGVPGLDLNVLAAWSQNITGRGVITAIMDDGVDYLHPDIAGNYAAEASYDFSSNDAFPYPRYTDDWFNSHGTRCAGEVAAIAGNGVCGVGVAPGSKVAGLRMLDQPYMTDLIEAAAMAYARDLIDIYSASWGPTDDGTTVDGPRNQTMRALVDGVNKGRKGKGSLYVWASGDGGENDDCNCDGYAASMWTISINSVTNDGHTAVYDESCASTLASTFSNGKSPFLRDAGVGTIDLYGNCTLHHSGTSAAAPEAAGVFALALEAQNELTWRDIQHLTVLTSKRNHLYDRQHNHNWTINGAGLEFNHLFGFGVLDAGDMVHLAKKWKTVPERFHCVAGTFNGRKIARLGQPIFLELDTDACMNNPINQVNYLEHVQAFITIKATRRGDITLFLTSPMNTTSMLLRRRPKDADNTRGFTKWPFMTTHMWSENPRGKWLLTIGLDSNSKDPLGYAILTEWILVVHGTQQPPYAHLSDSTINIAPKLGIVKKQHETKRFN 655          

Query:  436 ILLFLCEYVVCG------KIVTNQWHVHLHDPATQESANKVAQETGFSVLRNHLNSPNEFVFHHKTVPHVSSVPSWSQHKVLLAHHLVKNAKQVEGFLRRKRGYKPIKK-QGRVPLPTINKKGIPGLGESDNIKVDLKLPTDPLFSKEWYIRNTGQADGVKDLDLNVLSAWAQGITGKGVTTAIMDDGIDYLHPDLSKNYNAESSYDFSSNDPYPFPRYTDDWFNSHGTRCAGEISAERDNGICGVGVAYDSKIAGLRMLDQPYMTDLIEAAAMSYDRDNIDIYSASWGPTDDGRTVDGPRNETMRAIVEGVNKGRKGKGSIYVWASXXXXXXXXXXXXXXXXSMWTISINSATNDGETASYDESCSSTLASTFSNGKAWFSLDAGVGTVDLYGQCTLHHSGTSAAAPEAAGVFALALEANSNIGWRDMQHLTVLTSKXXXXXXXXXXXXWTINGAGLEFNHLFGYGVLDAGDMVRVAKKWVNVPERFHCIAGQIDKRYRFNVTKALILEIDTDACKSDIGHRVNYLEHVQAFVSVKSSRRGDITMFLTSPMGTTSMILSHRPKDDDSTRGFTKWPFMTTHTWGENPRGKWKLTVMFDTKDPLSQGIFSEWVLVLHGTQSRPYDKLSSSLEKIIPKLGVVKRQHASNRFSQ 2367
            ILL  C  V+         + TN +HV L     +E A +VA++TG  ++R HL    EF + H  VP   SV S    + +  H  V    Q+EGF R KRG+KP K  Q R       K+       SD        PTDP+F KEWYI+NTGQA G   LDLNVL AW +G+TG GVTTAIMDDGIDY+HPDL+ NYN E+SYDFSSNDPYP+PRYTDDWFNSHGTRCAGEIS++RDNGICGVGVAY SKIAGLRMLDQPYMTDLIEAAAMSY RD IDIYSASWGPTDDG+TVDGPRNETMRAIVEGVNKGR GKGSI+VWASGDGG  DDCNCDGYAASMWTISINSATNDGETA YDESCSSTLASTFSNGKA  +LDAGV TVDLYG+CTLHHSGTSAAAPEAAGVFALALEANSN+ WRDMQHL VLTSKRNHL+D + +H+WT+N AGLEFNHLFGYGVLDAGD+V+ A+ W  VPERFHCIAG++ + Y FNV  A+ +EIDTDACK D  HR+NY+EHVQAF+++KS+RRGD+T+FLT+P GTTS+ILS R KD DS  GFT WPFMTTH WGE+PRGKWKL V  D  D    G+ SEWVLV+HGTQ +PY KL S L     K+ V+K+ H    +++
Sbjct:    7 ILLGWCLLVIAAVTSSKESLFTNHFHVTLK-SGNEEVAKRVARDTGLRLVRRHLGKDTEFHYVHDQVPEADSVLS-RHLRSIADHEDVARVVQLEGFKRVKRGFKPAKATQSR------QKRS----ASSDE-------PTDPMFKKEWYIKNTGQAGGYPGLDLNVLPAWKEGVTGNGVTTAIMDDGIDYMHPDLAHNYNMEASYDFSSNDPYPYPRYTDDWFNSHGTRCAGEISSKRDNGICGVGVAYGSKIAGLRMLDQPYMTDLIEAAAMSYKRDIIDIYSASWGPTDDGKTVDGPRNETMRAIVEGVNKGRNGKGSIFVWASGDGGPDDDCNCDGYAASMWTISINSATNDGETALYDESCSSTLASTFSNGKA-STLDAGVATVDLYGKCTLHHSGTSAAAPEAAGVFALALEANSNLTWRDMQHLVVLTSKRNHLYDPNGKHDWTVNSAGLEFNHLFGYGVLDAGDIVKTARDWKTVPERFHCIAGEVKRLYHFNVQNAIEMEIDTDACKDDPKHRINYIEHVQAFITLKSTRRGDVTVFLTAPTGTTSLILSKRQKDADSKVGFTSWPFMTTHMWGESPRGKWKLKVALDATDASVHGVISEWVLVIHGTQEQPYKKLRSGLSS---KIDVIKKIHEKKSYTE 634          

Query:  496 VHLHDPATQESANKVAQETGFSVLRNHLNSPNEFVFHHKTVPHVSSVPSWSQHKVLLAHHLVKNAKQVEGFLRRKRGYKPIKKQGRVPLPTINKKGIPGLGESDNIKVDLKLPTDPLFSKEWYIRNTGQADGVKDLDLNVLSAWAQGITGKGVTTAIMDDGIDYLHPDLSKNYNAESSYDFSSNDPYPFPRYTDDWFNSHGTRCAGEISAERDNGICGVGVAYDSKIAGLRMLDQPYMTDLIEAAAMSYDRDNIDIYSASWGPTDDGRTVDGPRNETMRAIVEGVNKGRKGKGSIYVWASXXXXXXXXXXXXXXXXSMWTISINSATNDGETASYDESCSSTLASTFSNGKAWFSLDAGVGTVDLYGQCTLHHSGTSAAAPEAAGVFALALEANSNIGWRDMQHLTVLTSKXXXXXXXXXXXXWTINGAGLEFNHLFGYGVLDAGDMVRVAKKWVNVPERFHCIAGQIDKRYRFNVTKALILEIDTDACKSDIGHRVNYLEHVQAFVSVKSSRRGDITMFLTSPMGTTSMILSHRPKDDDSTRGFTKWPFMTTHTWGENPRGKWKLTVMFDTKDPLSQGIFSEWVLVLHGTQSRPY 2283
            V LH+ A  E A+++A + GF   R        F F+ +  P      S    + L     VKN    EGF R+KRGY+ I                      ++I V +    DPLFSK+WY+ NTGQADG   LDLNV  AW  G TGKGVT AIMDDGIDYLHPDL+ NYNAE+SYDFSSNDPYP+PRYTDDWFNSHGTRCAGE+SA  +N ICGVGVAY+SK+AG+RMLDQP+MTD+IEA+++S+    IDIYSASWGPTDDG+TVDGPR  T++A+ +GVNKGR GKGSIYVWASGDGG+ DDCNCDGYA+SMWTISINSA NDG TA YDESCSSTLASTFSNG+   + +AGV T DLYG CTL HSGTSAAAPEAAGVFALALEAN N+ WRDMQHLTVLTSK       D  H W  NG GLEFNHLFGYGVLDAG MV++A+ W  VPERFHC+AG + + ++    + L L I TDAC+      V YLEHVQA V+V +SRRGD+ + +TSPMGT S++LS RP+D D+  GF KWPFMTTHTWGE+PRG W L V F    P S G+  EW L+LHGTQS PY
Sbjct:   37 VQLHEGA-DEDAHQLAVDYGFGSARKLPFGERLFHFYPRDTPKTRRKRSLRHRQRLEKDRRVKNVIAQEGFDRQKRGYRDI----------------------NDIDVSM---NDPLFSKQWYLINTGQADGTPGLDLNVAEAWKMGYTGKGVTIAIMDDGIDYLHPDLASNYNAEASYDFSSNDPYPYPRYTDDWFNSHGTRCAGEVSAVSNNNICGVGVAYNSKVAGIRMLDQPFMTDIIEASSISHMPQVIDIYSASWGPTDDGKTVDGPRELTLQAMADGVNKGRGGKGSIYVWASGDGGSYDDCNCDGYASSMWTISINSAINDGRTALYDESCSSTLASTFSNGRK-RNPEAGVATTDLYGNCTLRHSGTSAAAPEAAGVFALALEANPNLTWRDMQHLTVLTSK--RNKLHDEVHQWRRNGVGLEFNHLFGYGVLDAGGMVKLAQDWKTVPERFHCVAGSVQEMHKIQSGEKLSLSISTDACQGKENF-VRYLEHVQAVVTVNASRRGDLNINMTSPMGTKSILLSRRPRDADAKVGFDKWPFMTTHTWGEDPRGTWLLEVGFQGDAPQS-GMLKEWTLMLHGTQSAPY 601          

Query:  472 KIVTNQWHVHLHDPATQESANKVAQETGFSVLRNHLNSPNEFV-FHHKTVPHVSSVPSWSQHKVLLAHHLVKNAKQVEGFLRRKRGYKPIKKQGRVPLPTINKKGIPGLGESDNIKVDLKLPTDPLFSKEWYIRNTGQADGVKDLDLNVLSAWAQGITGKGVTTAIMDDGIDYLHPDLSKNYNAESSYDFSSNDPYPFPRYTDDWFNSHGTRCAGEISAERDNGICGVGVAYDSKIAGLRMLDQPYMTDLIEAAAMSYDRDNIDIYSASWGPTDDGRTVDGPRNETMRAIVEGVNKGRKGKGSIYVWASXXXXXXX-XXXXXXXXXSMWTISINSATNDGETASYDESCSSTLASTFSNGKAWFSLDAGVGTVDLYGQCTLHHSGTSAAAPEAAGVFALALEANSNIGWRDMQHLTVLTSKXXXXXXXXXXXXWTINGAGLEFNHLFGYGVLDAGDMVRVAKKWVNVPERFHCIAGQIDKRYRFNVTKALILEIDTDACKSDIGHRVNYLEHVQAFVSVKSSRRGDITMFLTSPMGTTSMILSHRPKDDDSTRGFTKWPFMTTHTWGENPRGKWKLTVMFDTKDPLSQ-GIFSEWVLVLHGTQS 2274
            K+ TN W VH+     +E AN++A++  F    NH N   ++  F H+ V   S       H  L     V  A+Q     R+KR                                    P DP F+++WY+ N+   D      LNV  AW QG+TGKGV  +I+DDGI+  HPDL +NY+ ++SYD +  DP P PRYT    N HGTRCAGE++A  +N ICGVGVAY++KI G+RMLD   +TD +EA ++S +  +IDIYSASWGP DDG+TVDGP      A + GV +GR G GSI+VWASG+GG     CNCDGY  S++T+SI+S+T  G    Y E+CSSTLA+T+S+G      +  + T DL  +CT  H+GTSA+AP AAG+ ALALEAN N+ WRDMQHL V TS            +W  NG G + +H +GYG+LDA  +V +AK W NV  +  C+   + +    N+   L++  + D+C       V+ LEH QA +++  +RRG++ ++L SP GT S +L+ RP  D S+ GF  W FMTTH+W E+PRG+W L +  + K  LS  G  +++ L+L+GT S
Sbjct:   28 KVYTNTWAVHI--TGGEEEANRLARKHDFI---NHGNIFGDYYHFRHRRVVKRSLSEHRGTHIRLHREPQVSWAEQQVVKRRKKRDI-------------------------------YSEPADPKFAQQWYLYNSNHRD------LNVKEAWKQGVTGKGVVVSILDDGIEMNHPDLERNYDPDASYDVNDGDPDPQPRYTQLNDNRHGTRCAGEVAAVANNDICGVGVAYNAKIGGVRMLDGE-VTDAVEAQSLSLNPQHIDIYSASWGPEDDGKTVDGPAKLAKDAFLRGVTEGRGGLGSIFVWASGNGGREKDSCNCDGYTNSIYTLSISSSTQYGNVPWYSEACSSTLATTYSSGGL---NEKQIITTDLRQKCTDSHTGTSASAPLAAGIIALALEANKNLTWRDMQHLVVRTSN----PAHLTTDDWRTNGVGRKVSHSYGYGLLDAAAIVALAKNWTNVGPQQKCVLSLVSEPK--NIGSHLVISKNVDSCAGKPNF-VSSLEHAQAQLTLSYNRRGNLAIYLISPQGTRSTLLAGRPH-DYSSEGFNDWAFMTTHSWDEDPRGEWTLEI--ENKAGLSDFGTLTQFTLILYGTAS 575          

Query:  472 KIVTNQWHVHLHDPATQESANKVAQETGFSVLRNHLNSPNEFV-FHHKTVPHVSSVPSWSQHKVLLAHHLVKNAKQVEGFLRRKRGYKPIKKQGRVPLPTINKKGIPGLGESDNIKVDLKLPTDPLFSKEWYIRNTGQADGVKDLDLNVLSAWAQGITGKGVTTAIMDDGIDYLHPDLSKNYNAESSYDFSSNDPYPFPRYTDDWFNSHGTRCAGEISAERDNGICGVGVAYDSKIAGLRMLDQPYMTDLIEAAAMSYDRDNIDIYSASWGPTDDGRTVDGPRNETMRAIVEGVNKGRKGKGSIYVWASXXXXXXX-XXXXXXXXXSMWTISINSATNDGETASYDESCSSTLASTFSNGKAWFSLDAGVGTVDLYGQCTLHHSGTSAAAPEAAGVFALALEANSNIGWRDMQHLTVLTSKXXXXXXXXXXXXWTINGAGLEFNHLFGYGVLDAGDMVRVAKKWVNVPERFHCIAGQIDKRYRFNVTKALILEIDTDACKSDIGHRVNYLEHVQAFVSVKSSRRGDITMFLTSPMGTTSMILSHRPKDDDSTRGFTKWPFMTTHTWGENPRGKWKLTVMFDTKDPLSQ-GIFSEWVLVLHGTQS 2274
            K+ TN W VH+     +E AN++A++  F    NH N   ++  F H+ V   S       H  L     V  A+Q     R+KR                                    P DP F+++WY+ N+   D      LNV  AW QG+TGKGV  +I+DDGI+  HPDL +NY+ ++SYD +  DP P PRYT    N HGTRCAGE++A  +N ICGVGVAY++KI G+RMLD   +TD +EA ++S +  +IDIYSASWGP DDG+TVDGP      A + GV +GR G GSI+VWASG+GG     CNCDGY  S++T+SI+S+T  G    Y E+CSSTLA+T+S+G      +  + T DL  +CT  H+GTSA+AP AAG+ ALALEAN N+ WRDMQHL V TS            +W  NG G + +H +GYG+LDA  +V +AK W NV  +  C+   + +    N+   L++  + D+C       V+ LEH QA +++  +RRG++ ++L SP GT S +L+ RP  D S+ GF  W FMTTH+W E+PRG+W L +  + K  LS  G  +++ L+L+GT S
Sbjct:   28 KVYTNTWAVHI--TGGEEEANRLARKHDFI---NHGNIFGDYYHFRHRRVVKRSLSEHRGTHIRLHREPQVSWAEQQVVKRRKKRDI-------------------------------YSEPADPKFAQQWYLYNSNHRD------LNVKEAWKQGVTGKGVVVSILDDGIEMNHPDLERNYDPDASYDVNDGDPDPQPRYTQLNDNRHGTRCAGEVAAVANNDICGVGVAYNAKIGGVRMLDGE-VTDAVEAQSLSLNPQHIDIYSASWGPEDDGKTVDGPAKLAKDAFLRGVTEGRGGLGSIFVWASGNGGREKDSCNCDGYTNSIYTLSISSSTQYGNVPWYSEACSSTLATTYSSGGL---NEKQIITTDLRQKCTDSHTGTSASAPLAAGIIALALEANKNLTWRDMQHLVVRTSN----PAHLTTDDWRTNGVGRKVSHSYGYGLLDAAAIVALAKNWTNVGPQQKCVLSLVSEPK--NIGSHLVISKNVDSCAGKPNF-VSSLEHAQAQLTLSYNRRGNLAIYLISPQGTRSTLLAGRPH-DYSSEGFNDWAFMTTHSWDEDPRGEWTLEI--ENKAGLSDFGTLTQFTLILYGTAS 575          

Query:  475 IVTNQWHVHLHDPATQESANKVAQETGFSVLRNHLNSPNEFVFHHKTVPHVSSVPSWSQHKVLLAHHLVKNAKQVEGFLRRKRGYKPIKKQGRVPLPTINKKGIPGLGESDNIKVDLKLPTDPLFSKEWYIRNTGQADGVKDLDLNVLSAWAQGITGKGVTTAIMDDGIDYLHPDLSKNYNAESSYDFSSNDPYPFPRYTDDWFNSHGTRCAGEISAERDNGICGVGVAYDSKIAGLRMLDQPYMTDLIEAAAMSYDRDNIDIYSASWGPTDDGRTVDGPRNETMRAIVEGVNKGRKGKGSIYVWASXXXXXXX-XXXXXXXXXSMWTISINSATNDGETASYDESCSSTLASTFSNGKAWFSLDAGVGTVDLYGQCTLHHSGTSAAAPEAAGVFALALEANSNIGWRDMQHLTVLTSKXXXXXXXXXXXXWTINGAGLEFNHLFGYGVLDAGDMVRVAKKWVNVPERFHCIAGQIDKRYRFNVTKALILEIDTDACKSDIGHRVNYLEHVQAFVSVKSSRRGDITMFLTSPMGTTSMILSHRPKDDDSTRGFTKWPFMTTHTWGENPRGKWKLTVMFDTKDPLSQGIFSEWVLVLHGTQSRPYDKLSSSLEK 2310
            + T+ W VH+     +E A ++A +  F    N     + + F H++V   S       H  L +   V  A+Q     RRKR                                    PTDP F ++WY+ N  + D      L+V  AWAQG TG+GV   I+DDGI+  HPDL++NY+ ++SYD +  DP P PRYT    N HGTRCAGE++A  +NG+CGVGVAY+++I G+RMLD   +TD++EA ++S +  +I IYSASWGP DDG+TVDGP      A ++GV +GR G GSI+VWASG+GG     CNCDGY  S++T+SI+S T  G    Y E+CSSTLA+T+S+G      +  + T DL  +CT  H+GTSA+AP AAG+ ALALEAN N+ WRDMQHL V TS            +W  NG G   +H +GYG+LDA  MV +A+ W +V  +  C+   + +    +V   L+     +AC       V+ LEHVQA +++  S RG++ + L SP+GT S +L  RP+ D+S  GF  W FMTTH W E+PRG+W L +  +       G+ S++ L L+GT S   D  +S   K
Sbjct:   29 LYTDSWAVHIR--GGEEEAQRIAHKHNFIYHGNVFG--DYYHFQHRSVVKRSLSGHRGVHVRLQSEPQVVWAEQQVAKRRRKRDI-------------------------------YSEPTDPKFPQQWYLYNPNRRD------LHVKEAWAQGFTGRGVVITILDDGIEKDHPDLAQNYDPDASYDVNDRDPDPQPRYTQLNDNRHGTRCAGEVAAAANNGVCGVGVAYNARIGGVRMLDGE-VTDVVEAQSLSLNLQHIHIYSASWGPEDDGKTVDGPAKLAKEAFLQGVTEGRGGLGSIFVWASGNGGREKDSCNCDGYTNSIYTLSISSTTQYGNVPWYSEACSSTLATTYSSGNL---NEKQIVTTDLRKKCTDSHTGTSASAPLAAGIIALALEANMNLTWRDMQHLVVRTSH----PAHLITSDWRTNGVGRLVSHSYGYGLLDASAMVALARNWSSVGPQHKCVIDMLTEPR--DVRNHLMFSKSVEACSGQPDF-VSSLEHVQARLTLSYSHRGNLAIHLISPLGTRSTLLHPRPQ-DNSAEGFNDWAFMTTHAWDEDPRGEWTLEIE-NVAGLSDYGVLSQFTLFLYGTGSSATDLSASDFSK 587          

Query:  472 KIVTNQWHVHLHDPATQESANKVAQETGFSVLRNHLNSPNEFVFHHKTVPHVSSVPSWSQHKVLLAHHLVKNAKQVEGFLRRKRGYKPIKKQGRVPLPTINKKGIPGLGESDNIKVDLKLPTDPLFSKEWYIRNTGQADGVKDLDLNVLSAWAQGITGKGVTTAIMDDGIDYLHPDLSKNYNAESSYDFSSNDPYPFPRYTDDWFNSHGTRCAGEISAERDNGICGVGVAYDSKIAGLRMLDQPYMTDLIEAAAMSYDRDNIDIYSASWGPTDDGRTVDGPRNETMRAIVEGVNKGRKGKGSIYVWASXXXXXXXXXXXXXX-XXSMWTISINSATNDGETASYDESCSSTLASTFSNGKAWFSLDAGVGTVDLYGQCTLHHSGTSAAAPEAAGVFALALEANSNIGWRDMQHLTVLTSKXXXXXXXXXXXXWTINGAGLEFNHLFGYGVLDAGDMVRVAKKWVNVPERFHCIAGQIDKRYRFNVTKALILEIDTDACKSDIGHRVNYLEHVQAFVSVKSSRRGDITMFLTSPMGTTSMILSHRPKDDDSTRGFTKWPFMTTHTWGENPRGKWKLTVMF--DTKDPLSQGIFSEWVLVLHGTQSRPYDK 2289
            ++ TN+W V +     QE+A+ +A++ GF  +       + + F H      S+V S   H       L+    +VE +++++  ++ +K+  R                    +    L  DP +S  WYI      D     D+N+ + W +G TG GV  +I+DDG++ LHPDL +NY+A +S+D + ND  P PRY     N HGTRCAG ++A  +N +C VG+AY+++I G+RMLD   MTD++EA ++S  +  IDIYS+SWGP DDG+TVDGP      A+  G+ KGRKG+GSI+VWASG+GG   D         S++TIS+ S T  G    Y E CSSTLA+T+S+G+   S   G+ T DL  +CT  HSGTSA+AP AAG+ AL LEAN  + WRD+QH+ V TS+           +W  NGAG + +HL+G+G++DA  MV+ A+ W  VP +  C    +      +  K L L   +  C +     V Y+EHV   V++   RRGD+++ LTSP GT S +L+ RP +D ST GF KW FMTTH WGE   G W L +      K     G   EW LV +GT S PY +
Sbjct:   28 RLFTNRWAVRIR--GGQENADLIAEKYGFLNMGQIGGLKDHYNFLHPGGMKRSTVESRGNHS------LISTESEVE-WIQQQMVHRRVKRTERAS------------------QTHSTLFNDPKWSSMWYI----HCDHNCLTDMNIKAVWRRGYTGNGVVVSILDDGVERLHPDLKQNYDARASHDVNGNDSDPTPRYDATNENKHGTRCAGVVAAAANNSLCMVGIAYNARIGGVRMLDGD-MTDMVEAQSLSLRQQYIDIYSSSWGPDDDGKTVDGPGPLARLALENGIRKGRKGRGSIFVWASGNGGQRKDHCSCDGYTNSIFTISLGSTTQSGRKPWYLEECSSTLATTYSSGE---SQGLGIVTTDLRQRCTDEHSGTSASAPIAAGIIALTLEANPLLTWRDVQHIIVKTSR----RGHLSAPDWQSNGAGYDVSHLYGFGLMDAEAMVKEAETWREVPTQHVCEERTVQNARVISPEKVLRLLYKSSGCSAQRTQHVAYVEHVIIRVTITHPRRGDLSIALTSPAGTKSQLLALRP-NDHSTDGFVKWEFMTTHCWGEKAAGDWILEIRDSPSLKRNTRPGKLMEWALVFYGTSSHPYQR 596          

Query: 1354 KGRKGKGSIYVWASXXXXXXXXXXXXXXXXSMWTISINSATNDGETASYDESCSSTLASTFSNGKAWFSLDAGVGTVDLYGQCTLHHSGTSAAAPEAAGVFALALEANSNIGWRDMQHLTVL-----TSKXXXXXXXXXXXXWTINGAGLEFNHLFGYGVLDAGDMVRVAKKWVNVPERFHCIAGQIDKRYRFNVTKALILEIDTDACKSDIGHRVNYLEHVQAFVSVKSSRRGDITMFLTSPMGTTSMILSHRPKDDDSTRGFTKWPFMTTHTWGENPRGKWKLTVMFDTKDPLS-------QGIFSEWVLVLHGTQSRPYDKLSSSLEKIIPKLGVVKRQHASNRFSQ 2367
            +GR GKGS+YVWASGDGG+ DDCNCDGYA+SMWTISINSA NDG TA YDESCSSTLASTFSNG+     +AGV T DLYG CTL HSGTSAAAPEAAGVFALA+EA   + W      +V       S+ +           T + A   F      G L       + K+        H  A + +          L+L +DTDAC+    H V YLEHVQ  V+V ++RRGD+T+ LTSPMGT S++L  RP+D DS  GF +WPFMTTHTWGE+PRG+W L V F               G+ SEW L+LHGT S PY  +   +     KL + +RQ       +
Sbjct:    1 QGRGGKGSVYVWASGDGGSYDDCNCDGYASSMWTISINSAINDGRTALYDESCSSTLASTFSNGRK-KDPEAGVATTDLYGNCTLRHSGTSAAAPEAAGVFALAIEAK-GVEWLHNTSASVSLLPHSRSQSHPETAPCIARRTTTSDANRAFFVTKSRGFLGICHDFHLQKQPTT-----HLTAFRGEDVCAVPGQGRLVLTVDTDACEGRADH-VRYLEHVQVVVTVNATRRGDLTLNLTSPMGTRSLLLGRRPRDSDSRVGFHRWPFMTTHTWGEDPRGRWTLEVGFADGAEGPAAAAAARSGVLSEWTLMLHGTHSPPY--VGQVVHDSGSKLAMSRRQELEQELGE 340          

Query: 1933 LILEIDTDACKSDIGHRVNYLEHVQAFVSVKSSRRGDITMFLTSPMGTTSMILSHRPKDDDSTRGFTKWPFMTTHTWGENPRGKWKLTVMFDTKDPLS-------QGIFSEWVLVLHGTQSRPYDKLSSSLEKIIPKLGVVKRQ 2343
            L+L +DTDAC+    H V YLEHVQ  V+V ++RRGD+T+ LTSPMGT S++L  RP+D DS  GF +WPFMTTHTWGE+PRG+W L V F               G+ SEW L+LHGT S PY  +   +     KL + +RQ
Sbjct:  215 LVLTVDTDACEGRADH-VRYLEHVQVVVTVNATRRGDLTLNLTSPMGTRSLLLGRRPRDSDSRVGFHRWPFMTTHTWGEDPRGRWTLEVGFADGAEGPAAAAAARSGVLSEWTLMLHGTHSPPY--VGQVVHDSGSKLAMSRRQ 355          

Query: 1354 KGRKGKGSIYVWASXXXXXXXXXXXXXXXXSMWTISINSATNDGETASYDESCSSTLASTFSNGKAWFSLDAGVGTVDLYGQCTLHHSGTSAAAPEAAGVFALALEAN 1677
            +GR GKGS+YVWASGDGG+ DDCNCDGYA+SMWTISINSA NDG TA YDESCSSTLASTFSNG+     +AGV T DLYG CTL HSGTSAAAPEAAGVFALA+EAN
Sbjct:    1 QGRGGKGSVYVWASGDGGSYDDCNCDGYASSMWTISINSAINDGRTALYDESCSSTLASTFSNGRKK-DPEAGVATTDLYGNCTLRHSGTSAAAPEAAGVFALAIEAN 107          

Query:  742 KQGRVPLPTINKKGIPGLGESDNIKVDLKLP-TDPLFSKEWYIRNTGQADGVKDLDLNVLSAWAQGITGKGVTTAIMDDGIDYLHPDLSKNYNAESSYDFSSNDPYPFPRYTDDWFNSHGTRCAGEISAERDNGICGVGVAYDSKIAGLRMLDQPYMTDLIEAAAMSYDRDNIDIYSASWGPTDDGRTVDGPRNETMRAIVEGVNKGRKGKGSIYVWAS 1395
            +Q R  L ++ +KG+         +V   LP  DP F K+W+++      G   +DLNV   W +G+TGKGV  A++DDG+++  PDL  NY AE SYD +  D  P P  T D  + HGTRCAGEI+A  +N +CGVG AYDS++AG+R+LD P +TD +EA A +       IYS SWGP DDG+TVDGP      A+  GV  GR+G G+I+V AS
Sbjct:   54 RQHRSVLWSVEQKGLR--------RVKRSLPFNDPKFPKQWHLQRNTHTPG---MDLNVTGVWERGVTGKGVVVAVVDDGVEHTLPDLQSNYCAEGSYDLTDGDQDPRPG-TGDQESRHGTRCAGEIAAVANNSLCGVGAAYDSRVAGIRLLDGP-LTDHMEATAFNTHYQLNHIYSCSWGPDDDGKTVDGPHVLGQSALQRGVVGGRRGFGTIFVVAS 259          

Query:  832 PTDPLFSKEWYIRNTGQADGVKDLDLNVLSAWAQGITGKGVTTAIMDDGIDYLHPDLSKNYNAESSYDFSSNDPYPFPRYTD 1077
            PTDP +  +WY+ N+   D      LNVL+AW+QG++G+GV  +I+DDGI+  HPDL  NY+  +SYD +SNDP P PRYT+
Sbjct:  115 PTDPKYLLQWYLHNSVHHD------LNVLAAWSQGVSGRGVVVSILDDGIEKNHPDLVSNYDPMASYDVNSNDPDPQPRYTE 190          

Query:  742 KQGRVPLPTINKKGIPGLGESDNIKVDLKLPTDPLFSKEWYIRNTGQADGVKDLDLNVLSAWAQGITGKGVTTAIMDDGIDYLHPDLSKNYNAESSYDFSSNDPYPFPRYTDDWFNSHGTRCAGEISAERDNGICGVGVAYDSKIAGLRMLDQPYMTDLIEAAAMSYDRDNIDIYSASWGPTDDGRTVDGPRNETMRAIVEGVNKGRKGKGSIYVWAS-XXXXXXXXXXXXXXXXSMWTISINSATNDGETASYDESCSSTLASTFSNGKAWFSLDAGVGTVDLYGQCTLHHSGTSAAAPEAAGVFALALEANSNIGWRDMQHLTVLTSKXXXXXXXXXXXXWTINGAGLEFNHLFGYGVLDAGDMVRVAKKWVNVPERFHCIAGQIDKRYRFNVTKALILEIDTDACKSDIGHRVNYLEHVQAFVSVKSSRRGDITMFLTSPMGTTSMILSHRPKDDDSTRGFTKWPFMTTHTWGENPRGKWKLTVMFDTKDPLSQGIFSEWVLVLHG 2265
            K+  VP P ++   +P     D + ++     DPLF ++W++ N          D+NVL  W   ITG GV  AI+DDG+DY + DL  N+ AE S+DF+ N   P PR +DD+   HGTRCAGEI+A++ N  CGVGV Y++KI+G+R+L     T+  EAA++ Y  D  DIYS SWGP DDGR + GP +   +A+V+GV +GR  KG+IYV+AS   G   D+CN DGY  S+++I+I +  +      Y E CS+ +A T+S+G   +     + + D+ G+C+  H GTSAAAP AAGV+ L LEAN N+ WRD+Q+L++L++      +++   +W  +  G +++H +G+G +DA  ++ ++K W NV  +       +      N T+  +  + T + KS        +EHV   V + +  RG  T+ L SP G  S +   RP+ D S+ GF  W FM+   WGEN  G WK+ V   T +   +  F  W L L G
Sbjct:  108 KRLPVPAPPMDSSLLPVKEAEDKLSIN-----DPLFERQWHLVNPS----FPGSDINVLDLWYNNITGAGVVAAIVDDGLDYENEDLKDNFCAEGSWDFNDNTNLPKPRLSDDY---HGTRCAGEIAAKKGNNFCGVGVGYNAKISGIRILSGDITTE-DEAASLIYGLDVNDIYSCSWGPADDGRHLQGPSDLVKKALVKGVTEGRDSKGAIYVFASGNGGTRGDNCNYDGYTNSIYSITIGAIDHKDLHPPYSEGCSAVMAVTYSSGSGEY-----IHSSDINGRCSNSHGGTSAAAPLAAGVYTLLLEANPNLTWRDVQYLSILSA---VGLEKNADGDWRDSAMGKKYSHRYGFGKIDAHKLIEMSKTWENVNAQTWFYLPTLYVSQSTNSTEETLESVITISEKSLQDANFKRIEHVTVTVDIDTEIRGTTTVDLISPAGIISNLGVVRPR-DVSSEGFKDWTFMSVAHWGENGVGDWKIKVK--TTENGHRIDFHSWRLKLFG 592          

Query:  472 KIVTNQWHVHLHDPATQESANKVAQETGFSVLRNHLNSPNEFVFHHKTVPHVSSVPSWSQHKVLLAHHLVKNAKQVEGFLRRKRGYKPIKKQGRVPLPTINKKGIPGLGESDNIKVDLKLPTDPLFSKEWYIRNTGQADGVKDLDLNVLSAWAQGITGKGVTTAIMDDGIDYLHPDLSKNYNAESSYDFSSNDPYPFPRYTDDWFNSHGTRCAGEISAERDNGICGVGVAYDSKIAGLRMLDQPYMTDLIEAAAMSYDRDNIDIYSASWGPTDDGRTVDGPRNETMRAIVEGVNKGRKGKGSIYVWAS-XXXXXXXXXXXXXXXXSMWTISINSATNDGETASYDESCSSTLASTFSNGKAWFSLDAGVGTVDLYGQCTLHHSGTSAAAPEAAGVFALALEANSNIGWRDMQHLTVLTSKXXXXXXXXXXXXWTINGAGLEFNHLFGYGVLDAGDMVRVAK--KWVNVPERFHCIAGQIDKRYR-FNVTKALILEIDTDACKSDIGHRVNYLEHVQAFVSVKSSRRGDITMFLTSPMGTTSMILSHRPKDDDSTRGFTKWPFMTTHTWGENPRGKWKLTVMFDTKDPLSQGIFSEWVLVLHGTQSRP 2280
            ++ TN W +H++     E A +VA+  GF  +         +   H + P  S   +  +   L  H  V   +Q    +R KRG+   +   R  +P                        DPL+  +WY+ +  +     DLD++V+  W +GI+GKGV   I+DDGI++ H DL KNY+  +S+D +  D  PFPRY     N HGTRCAGE++AE +N  CGVGVA++++I G+RMLD   +TD +EA ++S +   IDIYSASWGP+DDG TV+GP      A + G+ KGR G GSI+VWAS   G   D CNCDGY  S++T+SI+SA++ GE+  Y ESCSSTLA+TFS+G      +  + T DL+  CT  H+GTSA+AP AAG+FALALE N  + WRDMQH+ V TS            +W+ NG  L  N  FG+G+L A  +V +A    +V VPE+  C  GQI++  + F   K L +++    C S  G  + YLEHVQ  VS+   RRGD+ ++LTSPMGT S +LS R K+D S  GF+KWPFMTTH+WGE+PRG W L +     +  + G   EW L+LHGT+ +P
Sbjct:   39 RVYTNGWAIHVN--GGIEEAKEVAKAHGFEKVEPIGTLEGYYHLEHPSHPSRSRRSAEDRTDQLRQHRHVTWVEQQHEKVREKRGFYHDRMVARGIVPRFK---------------------DPLWDAQWYLDDKRKD---TDLDIHVIPVWKKGISGKGVVVTILDDGIEHNHTDLIKNYDPNASWDVNDGDNDPFPRYDPTNENKHGTRCAGEVAAEANNTKCGVGVAFNARIGGVRMLDG-RVTDKVEAESLSLNPQYIDIYSASWGPSDDGATVEGPGTLATAAFLNGIQKGRGGLGSIFVWASGNGGRHGDSCNCDGYTDSIYTLSISSASDHGESPWYSESCSSTLATTFSSGA---HGEKRIVTTDLHNTCTERHTGTSASAPLAAGIFALALEVNPKLTWRDMQHIVVHTSN---HLPLKHDQDWSKNGIDLMVNRKFGFGLLVAEKIVDMANPATYVTVPEKRFC-RGQINQDAKVFKWDKPLTIQLPATGC-SGTGDEIRYLEHVQLMVSLDYVRRGDLVIYLTSPMGTKSCLLSPR-KEDSSNEGFSKWPFMTTHSWGEDPRGTWTLEIKDLGDNKANHGTLREWQLILHGTKDKP 609          

Query:  457 YVVCGK-IVTNQWHVHLHDPATQESANKVAQETGFSVLRNHLNSPNEFVFHHKTVPHVSSVPSWSQHKVLLAHHLVKNAKQVEGFLRRKRGYKPIKKQGRVPLPTINKKGIPGLGESDNIKVDLKLPTDPLFSKEWYIRNTGQADGVKDLDLNVLSAWAQGITGKGVTTAIMDDGIDYLHPDLSKNYNAESSYDFSSNDPYPFPRYTDDWFNSHGTRCAGEISAERDNGICGVGVAYDSKIAGLRMLDQPYMTDLIEAAAMSYDRDNIDIYSASWGPTDDGRTVDGPRNETMRAIVEGVNKGRKGKGSIYVWASXXXXXXX-XXXXXXXXXSMWTISINSATNDGETASYDESCSSTLASTFSNGKAWFSLDAGVGTVDLYGQCTLHHSGTSAAAPEAAGVFALALEANSNIGWRDMQHLTVLTSKXXXXXXXXXXXXWTINGAGLEFNHLFGYGVLDAGDMVRVAK--KWVNVPERFHCIAGQIDKRYRFNVTKALILEIDTDACKSDIGHRVNYLEHVQAFVSVKSSRRGDITMFLTSPMGTTSMILSHRPKDDDSTRGFTKWPFMTTHTWGENPRGKWKLTVMFDTKDPLSQGIFSEWVLVLHGTQSRPYDKLSSS 2301
            +V+  K + TN W ++      QE  + +A + GF   R+       ++  H+                 L    V  AKQ +   R+KRG+                                    DPLF+ +WY+ N GQ  G K LD+NVL  W + ITGK V   I+DDGI+Y HPDL +NY+ E+SYD++  D  PFPRY+ D  N HGTRCAGE++A + N  CGVGVAY+++I G+RMLD   +TD++E  ++S     IDIYS+SWGP DDGRTVDGP     RA  +G+ KGR+G GSI+VWA+G+GG  +  CNCDGY  S++TISI +  + G++  Y E+C STL  T+S+G+     D  + T DL+ +CT  H+GTSAAAP AAG+FAL LEAN  + WRD+QHL V TSK            W  NGAG   N+ +G+GVLD+  +V +A+  KW    E+  C                L L +D   C S   + V  LEHV+ +V+++  RRG I++ L SP GT S +L  R K D S  GF  WPFMT  +W ENP GKWKL V        + G F  W +   GT  RP   +++S
Sbjct:   20 FVLASKPLYTNTWVIYTD--KGQEYVDNLAAKHGFKSHRDGGGLEGFYILEHQRTSKRMRRSLVHHSTNFLRDPHVSYAKQQKILRRQKRGF-----------------------------------VDPLFNDQWYLNNYGQTPGPKGLDINVLPVWRKNITGKNVVVTILDDGIEYTHPDLQQNYDKEASYDYNHYDSDPFPRYSPDNINKHGTRCAGEVAAIK-NTHCGVGVAYNARIGGIRMLDGD-VTDIVEGKSLSLKTGYIDIYSSSWGPDDDGRTVDGPGPMAKRAFRDGIKKGRRGLGSIFVWATGNGGRYNDYCNCDGYITSIYTISIGAINDKGKSPWYAENCPSTLGVTYSSGQT-NGPDLQIVTTDLHHKCTKEHTGTSAAAPLAAGIFALVLEANPKLTWRDLQHLVVNTSK----KTDAGDSEWITNGAGHHVNNKYGFGVLDSAALVELAQSPKWRTAEEQHVCREPGSSSSQEIPKNGELTLTLDATGC-SGKSNCVTRLEHVRVYVTLRHDRRGAISIVLISPSGTRSDLLKQRSK-DFSNNGFKNWPFMTVFSWNENPVGKWKLVVR---NHASTAGTFDRWFIKFFGTCQRPRKNITAS 589          

Query:  481 TNQWHVHLHDPATQESANKVAQETGFSVLRNHLNSPNEFVFHHKTVPHVSSVPSWSQHKVLLAHHLVKNAKQVEGFLRRKRGYKPIKKQGRVPLPTINKKGIPGLGESDNIKVDLKLPTDPLFSKEWYIRNTGQADGVKDLDLNVLSAWAQGITGKGVTTAIMDDGIDYLHPDLSKNYNAESSYDFSSNDPYPFPRYTDDWFNSHGTRCAGEISAERDNGICGVGVAYDSKIAGLRMLDQPYMTDLIEAAAMSYDRDNIDIYSASWGPTDDGRTVDGPRNETMRAIVEGVNKGRKGKGSIYVWASXXXXXXXXXXXXXX-XXSMWTISINSATNDGETASYDESCSSTLASTFSNGKAWFSLDAGVGTVDLYGQCTLHHSGTSAAAPEAAGVFALALEANSNIGWRDMQHLTVLTSKXXXXXXXXXXXXWTINGAGLEFNHLFGYGVLDAGDMVRVAKKWVNVPERFHCIAGQ--IDKRYRFNVTKALILEIDTDACKSDIGHRVNYLEHVQAFVSVKSSRRGDITMFLTSPMGTTSMILSHRPKDDDSTRGFTKWPFMTTHTWGENPRGKWKLTVMFDTKDPLSQ 2229
            TN W V +  P  ++   ++++  GF+++    N    +   H  V  ++   +  +   LL    V+ A+Q +  L R R                 K GI               PTDP+F++ WY+ NTGQ  G   +D+NV+  W +GITG+GV   ++DDG+D+ HPDL  NY   +S+DF+ ND  P PR  D   N HGTRCAGEI+A  ++ ICG GVAY++KI G+RMLD    TD +EA ++ +     D+YS  WGP DDG+T   P     +A+  G  KGR GKG+I+VWA+G+GG  DD         S++T+SI    + G +A Y E CSSTLA TF+ G      +  + T DL G+CT    GTS+AAP AAG+ AL LE N ++ WRD+QH+ V T+K            W  NGAGL FNH FG+G LDA  MV  ++ W NVP +  C              V  +L ++I T  C   I   +N+LEHV   VS    RRGD+++ LTSP GT + +LS R + DDS  G  KW FMT H WGENPRG WKL V+    +PL++
Sbjct:    6 TNTWAVEIEHPFEEKYVREISKRHGFTIIGKIGNLKGHYHLRHDDVDELNKEHNRDKTDRLLLEDNVRWAEQ-QKILHRVR-----------------KDGI---------------PTDPMFTEMWYLMNTGQTGGPVGVDINVIPVWKRGITGRGVVVTVLDDGMDHNHPDLKPNYEPCASHDFNDNDQDPAPRDIDP-DNCHGTRCAGEIAAVANDSICGAGVAYNAKIGGVRMLDGK-ATDALEACSLGFANQVTDVYSNCWGPKDDGKTFGKPGPLAAKALKSGAEKGRGGKGNIFVWATGNGGLTDDDCNCDGYTTSIYTVSIGCIGDHGLSAYYTELCSSTLAVTFNGGAHREKEENKMITTDLKGKCTEQFKGTSSAAPLAAGMVALMLEQNPSLTWRDVQHIIVHTAK----MTSPVDDGWRTNGAGLHFNHKFGFGRLDADAMVEKSRVWKNVPVQRTCTGASSVTGDEKDIPVGGSLDIQIPTGGCMGTIA-EINHLEHVVLTVSFIHRRRGDVSLLLTSPSGTKNEMLSTR-RYDDSKEGLDKWSFMTVHCWGENPRGFWKLNVI---DNPLNE 547          

Query:  838 DPLFSKEWYIRNTGQADGVKDLDLNVLSAWAQGITGKGVTTAIMDDGIDYLHPDLSKNYNAESSYDFSSNDPYPFPRYTDDWFNSHGTRCAGEISAERDNGICGVGVAYDSKIAGLRMLDQPYMTDLIEAAAMSYDRDNIDIYSASWGPTDDGRTVDGPRNETMRAIVEGVNKGRKGKGSIYVWAS-XXXXXXXXXXXXXXXXSMWTISINSATNDGETASYDESCSSTLASTFSNGKAWFSLDAGVGTVDLYGQCTLHHSGTSAAAPEAAGVFALALEANSNIGWRDMQHLTVLTSKXXXXXXXXXXXXWTINGAGLEFNHLFGYGVLDAGDMVRVAKKWVNVPER---FHCIAGQIDKRYRFNVTKALILEIDTDACKSDIGHRVNYLEHVQAFVSVKSSRRGDITMFLTSPMGTTSMILSHRPKDDDSTRGFTKWPFMTTHTWGENPRGKWKLTVMFDTKDP 2220
            DPLF ++W++       G +  D +VL  W  G+ GK V  +I+DDGI+Y H DL +NY+  +SYDF+SND  P PRYT +  N HGTRCAGE++A+ +N +CGVGVA  +K+ G+RMLD   +TD +EA ++S +  +IDIYSASWGP DDG+TVDGP     +A  +G+ KGR GKGSIYVWAS   G  +D+CNCDGY  S++T+SI+S T  G +  Y E+CSSTLAS FS+G +W   +  + TVD+  +CT  H+GTSA+AP AAG+ A+ALE N N+ WRDMQH+ V T   + L+  D       NG G   +H FGYG+LDA  +V++A+ W  VP +   F  I  +I          AL +  +   C +   + + YLEHV+  +S+ S +RGDI+++LTSP GT S +L  R + D+S  GF  W FMTTH+W ENP G W L + F+ K P
Sbjct:    1 DPLFEEQWHLA------GYEAFDHHVLPVWQMGVYGKDVVVSILDDGIEYTHDDLKENYDKLASYDFNSNDADPAPRYTWNDENRHGTRCAGEVAAQMNNSVCGVGVAPKAKVGGVRMLDGD-VTDAVEAGSLSLNPQHIDIYSASWGPDDDGKTVDGPARLARKAFTDGIEKGRGGKGSIYVWASGNGGRTSDNCNCDGYTNSIYTLSISSVTEIGNSPWYSEACSSTLASAFSSG-SWN--NRKIVTVDVRNRCTKTHTGTSASAPLAAGILAMALEVNRNLTWRDMQHIVVRTCTMDKLNMHDV----VTNGVGRLVSHTFGYGLLDATRLVKLARVWRTVPPQRVSFLFIYRKIPD------DGALTVRTEATGC-TGTANEIRYLEHVECIISLDSVKRGDISIYLTSPRGTRSTLLGKRIR-DNSQNGFHDWAFMTTHSWEENPTGTWTLEI-FNEKTP 442          

Query:  475 IVTNQWHVHLHDPATQESANKVAQETGFSVLRNHLNSPNEFVFHHKTVPHVSSVPSWSQHKVLLAHHLVKNAKQVEGFLRRKRGYKPIKKQGRVPLPTINKKGIPGLGESDNIKVDLKLPTDPLFSKEWYIRNTGQADGVKDLDLNVLSAWAQGITGKGVTTAIMDDGIDYLHPDLSKNYNAESSYDFSSNDPYPFPRYTDDWFNSHGTRCAGEISAERDNGICGVGVAYDSKIAGLRMLDQPYMTDLIEAAAMSYDRDNIDIYSASWGPTDDGRTVDGPRNETMRAIVEGVNKGRKGKGSIYVWASXXXXXXXXXXXXXX-XXSMWTISINSATNDGETASYDESCSSTLASTFSNGKAWFSLDAGVGTVDLYGQCTLHHSGTSAAAPEAAGVFALALEANSNIGWRDMQHLTVLTSKXXXXXXXXXXXXWTINGAGLEFNHLFGYGVLDAGDMVRVAKKWVNVPERFHCIAGQIDKRYRFNVTKALILEIDTDACKSDIGHRVNYLEHVQAFVSVKSSRRGDITMFLTSPMGTTSMILSHRPKDDDSTRGFTKWPFMTTHTWGENPRGKWKLTVMFDTKDPLSQGI 2235
            + TN W V L D A  E+A+++A + GF+ L   + S   + +H K V      P     + L  H   +   Q +  L  +R +   + +  +                        +P DP F  +WY+ N GQ+ G   +D++V+ AW + ITG+GV  +I+DDG+D+ HPDL  N++ ++SYDF+  DP P PR +D   N HGTRCAGE++A  +N +CGVGVAY++ I G+RMLD    TD++E +++S+    IDIYS  WGP DDG+T   P      A+++G  KGR G+G+IYVWA+G+GG  DD         S++TISI    + G +A Y E CSSTL  TF+ G      +  + T DL+ +CT    GTS+AAP AAG+ AL LEAN N+ WRD+QHL V T++            W  NGAG  FNH FG+G LDA  MV+ AK W +V  +  C       +        L + IDT AC S     +  LEHV   VS +  RRGD+++ L SP GT + +LS R + DDS  G   W FMT H WGENP+G+W + V  D    L++G+
Sbjct:    1 MFTNSWAVQL-DSAEVEAADRIAAKHGFTNL-GQVGSLKGY-YHFKHV----HKPGNRARRELHVHEKTRLLMQEDEVLWAQRQHVLARTRKYI------------------------VPHDPKFHDQWYLFNDGQSTGPAGVDIDVVPAWNRNITGRGVVVSILDDGVDHTHPDLRDNFDQKASYDFNDMDPDPRPRDSDP-DNCHGTRCAGEVAAA-NNDVCGVGVAYNANIGGVRMLDG-QATDVLEGSSLSFQSAYIDIYSNCWGPKDDGKTFGKPGKLAQEALMQGALKGRGGRGNIYVWATGNGGLTDDDCNCDGYTTSIYTISIGCIGDHGLSAYYTELCSSTLGVTFNGGSHREREENKMVTTDLHHKCTEEFKGTSSAAPLAAGMIALVLEANPNLSWRDVQHLVVETAQ----VTSPVDEGWMKNGAGYHFNHKFGFGRLDADAMVKRAKTWKSVAPQRICHGPSSSTQQEIPTGGTLSITIDTIAC-SGTDKMLTKLEHVTLTVSFQHRRRGDVSIDLFSPSGTRNEMLSTR-RYDDSKNGLHDWTFMTVHNWGENPKGEWVMNVT-DNLSALNKGV 547          

Query:  439 LLFLCEYVVCGKIVTNQWHVHLHDPATQESANKVAQETGFSVLRNHLNSPNEFVFHHKTVPHVSSVPSWSQHKVLLAHHLVKNAKQVEGFLRRKRGYKPIKKQGRVPLPTINKKGIPGLGESDNIKVDLKLPTDPLFSKEWYIRNTGQADGVKDLDLNVLSAWAQGITGKGVTTAIMDDGIDYLHPDLSKNYNAESSYDFSSNDPYPFPRYTDDWFNSHGTRCAGEISAERDNGICGVGVAYDSKIAGLRMLDQPYMTDLIEAAAMSYDRDNIDIYSASWGPTDDGRTVDGPRNETMRAIVEGVNKGRKGKGSIYVWASXXXXXXXXXXXXXXXXSMWTISINSATNDGETASYDESCSSTLASTFSNGKAWFSLDAGVGTVDLYGQCTLHHSGTSAAAPEAAGVFALALEANSNIGWRDMQHLTVLTSKXXXXXXXXXXXXWTINGAGLEFNHLFGYGVLDAGDMVRVAKKWVNVPERFHCIAGQIDKRYRFNVTKALILEIDTDACKSDIGHRVNYLEHVQAFVSVKSSRRGDITMFLTSPMGTTSMILSHRPKDDDSTRGFTKWPFMTTHTWGENPRGKWKLTVMFDTKDPLSQGIFSEWVLVLHGTQSRPY 2283
            LLF  E      ++T    V LH+ A Q+ A+++A + GF   R        F F+ +      S  S    + L  +  VKN  + EGF R+KRGY+ I                      ++I+V++   +DPLF+K+WY+ NTGQADG   LDLNV  AW  G TGKGVT AIMDDGIDYLHPDL+ NYNA++SYDFSSNDP+PFPRYTDDWFNSHGTRCAGE+SA  +N ICGVGVAY+SK+AG+RMLDQP+MTD+IEA+++S+    IDIYSASWGPTDDG+TVDGPR  T++A+ +GVNKGR GKGSIYVWASGDGG+ DDCNCDGYA+SMWTISINSA NDG TA YDESCSSTLASTFSNG+   + +AGV T DLYG CTL HSGTSAAAPEAAGVFALALEAN N+ WRDMQHL+VLTSK       D  H W  NG GLEFNHLFGYGVLDAG MV++AK+W  VPERFHC+AG I + ++      L+L I+T+AC+    + V YLEHVQA V+V ++RRGD+ + +TSPMGT S++LS RP+DDDS  GF KWPFMTTHTWGE+PRG W L V F    P  +G+  EW ++LHGTQS PY
Sbjct:   20 LLFATE--AAEGVLTEHLLVQLHEDA-QDEAHQLAAQHGFQSARKLPFGDGLFHFYPQDTSKRRSKRSARIKQWLQNNRRVKNVIEQEGFRRQKRGYRNI----------------------NDIEVNM---SDPLFTKQWYLINTGQADGTPGLDLNVAEAWQLGYTGKGVTIAIMDDGIDYLHPDLASNYNADASYDFSSNDPFPFPRYTDDWFNSHGTRCAGEVSAAANNNICGVGVAYNSKVAGIRMLDQPFMTDIIEASSISHMPQTIDIYSASWGPTDDGKTVDGPRELTLQAMADGVNKGRGGKGSIYVWASGDGGSYDDCNCDGYASSMWTISINSAINDGRTALYDESCSSTLASTFSNGRK-RNPEAGVATTDLYGNCTLRHSGTSAAAPEAAGVFALALEANPNLTWRDMQHLSVLTSK--RNQLHDEVHQWRRNGVGLEFNHLFGYGVLDAGGMVKMAKEWKTVPERFHCVAGSIQEPHKIQSGNKLVLAINTEACEGK-DNFVRYLEHVQAVVTVNATRRGDLNINMTSPMGTKSLLLSRRPRDDDSKVGFDKWPFMTTHTWGEDPRGTWVLEVGFQGDQP-QRGVLKEWTVMLHGTQSAPY 601          

Query:  439 LLFLCEYVVCGKIVTNQWHVHLHDPATQESANKVAQETGFSVLRNHLNSPNEFVFHHKTVPHVSSVPSWSQHKVLLAHHLVKNAKQVEGFLRRKRGYKPIKKQGRVPLPTINKKGIPGLGESDNIKVDLKLPTDPLFSKEWYIRNTGQADGVKDLDLNVLSAWAQGITGKGVTTAIMDDGIDYLHPDLSKNYNAESSYDFSSNDPYPFPRYTDDWFNSHGTRCAGEISAERDNGICGVGVAYDSKIAGLRMLDQPYMTDLIEAAAMSYDRDNIDIYSASWGPTDDGRTVDGPRNETMRAIVEGVNKGRKGKGSIYVWASXXXXXXXXXXXXXXXXSMWTISINSATNDGETASYDESCSSTLASTFSNGKAWFSLDAGVGTVDLYGQCTLHHSGTSAAAPEAAGVFALALEANSNIGWRDMQHLTVLTSKXXXXXXXXXXXXWTINGAGLEFNHLFGYGVLDAGDMVRVAKKWVNVPERFHCIAGQIDKRYRFNVTKALILEIDTDACKSDIGHRVNYLEHVQAFVSVKSSRRGDITMFLTSPMGTTSMILSHRPKDDDSTRGFTKWPFMTTHTWGENPRGKWKLTVMFDTKDPLSQGIFSEWVLVLHGTQSRPY 2283
            LLF  E      ++T    V LH+ A Q+ A+++A + GF   R        F F+ +      S  S    + L  +  VKN  + EGF R+KRGY+ I                      ++I+V++   +DPLF+K+WY+ NTGQADG   LDLNV  AW  G TGKGVT AIMDDGIDYLHPDL+ NYNA++SYDFSSNDP+PFPRYTDDWFNSHGTRCAGE+SA  +N ICGVGVAY+SK+AG+RMLDQP+MTD+IEA+++S+    IDIYSASWGPTDDG+TVDGPR  T++A+ +GVNKGR GKGSIYVWASGDGG+ DDCNCDGYA+SMWTISINSA NDG TA YDESCSSTLASTFSNG+   + +AGV T DLYG CTL HSGTSAAAPEAAGVFALALEAN N+ WRDMQHL+VLTSK       D  H W  NG GLEFNHLFGYGVLDAG MV++AK+W  VPERFHC+AG I + ++      L+L I+T+AC+    + V YLEHVQA V+V ++RRGD+ + +TSPMGT S++LS RP+DDDS  GF KWPFMTTHTWGE+PRG W L V F    P  +G+  EW ++LHGTQS PY
Sbjct:   20 LLFATE--AAEGVLTEHLLVQLHEDA-QDEAHQLAAQHGFQSARKLPFGDGLFHFYPQDTSKRRSKRSARIKQWLQNNRRVKNVIEQEGFRRQKRGYRNI----------------------NDIEVNM---SDPLFTKQWYLINTGQADGTPGLDLNVAEAWQLGYTGKGVTIAIMDDGIDYLHPDLASNYNADASYDFSSNDPFPFPRYTDDWFNSHGTRCAGEVSAAANNNICGVGVAYNSKVAGIRMLDQPFMTDIIEASSISHMPQTIDIYSASWGPTDDGKTVDGPRELTLQAMADGVNKGRGGKGSIYVWASGDGGSYDDCNCDGYASSMWTISINSAINDGRTALYDESCSSTLASTFSNGRK-RNPEAGVATTDLYGNCTLRHSGTSAAAPEAAGVFALALEANPNLTWRDMQHLSVLTSK--RNQLHDEVHQWRRNGVGLEFNHLFGYGVLDAGGMVKMAKEWKTVPERFHCVAGSIQEPHKIQSGNKLVLAINTEACEGK-DNFVRYLEHVQAVVTVNATRRGDLNINMTSPMGTKSLLLSRRPRDDDSKVGFDKWPFMTTHTWGEDPRGTWVLEVGFQGDQP-QRGVLKEWTVMLHGTQSAPY 601          

Query:  595 FVFHHKTVPHVSSVPSWSQHKVLLAHHLVKNAKQVEGFLRRKRGYKPIKKQGRVPLPTINKKGIPGLGESDNIKVDLKLPTDPLFSKEWYIRNTGQADGVKDLDLNVLSAWAQGITGKGVTTAIMDDGIDYLHPDLSKNYNAESSYDFSSNDPYPFPRYTDDWFNSHGTRCAGEISAERDNGICGVGVAYDSKIAGLRMLDQPYMTDLIEAAAMSYDRDNIDIYSASWGPTDDGRTVDGPRNETMRAIVEGVNKGRKGKGSIYVWASXXXXXXXXXXXXXXXXSMWTISINSATNDGETASYDESCSSTLASTFSNGKAWFSLDAGVGTVDLYGQCTLHHSGTSAAAPEAAGVFALALEANSNIGWRDMQHLTVLTSKXXXXXXXXXXXXWTINGAGLEFNHLFGYGVLDAGDMVRVAKKWVNVPERFHCIAGQIDKRYRFNVTKALILEIDTDACKSDIGHRVNYLEHVQAFVSVKSSRRGDITMFLTSPMGTTSMILSHRPKDDDSTRGFTKWPFMTTHTWGENPRGKWKLTVMFDTKDPLSQGIFSEWVLVLHGTQSRPY 2283
            F F+ +      S  S    + L  +  VKN  + EGF R+KRGY+ I                      ++I+V++   +DPLF+K+WY+ NTGQADG   LDLNV  AW  G TGKGVT AIMDDGIDYLHPDL+ NYNA++SYDFSSNDP+PFPRYTDDWFNSHGTRCAGE+SA  +N ICGVGVAY+SK+AG+RMLDQP+MTD+IEA+++S+    IDIYSASWGPTDDG+TVDGPR  T++A+ +GVNKGR GKGSIYVWASGDGG+ DDCNCDGYA+SMWTISINSA NDG TA YDESCSSTLASTFSNG+   + +AGV T DLYG CTL HSGTSAAAPEAAGVFALALEAN N+ WRDMQHL+VLTSK       D  H W  NG GLEFNHLFGYGVLDAG MV++AK+W  VPERFHC+AG I + ++      L+L I+T+AC+    + V YLEHVQA V+V ++RRGD+ + +TSPMGT S++LS RP+DDDS  GF KWPFMTTHTWGE+PRG W L V F    P  +G+  EW ++LHGTQS PY
Sbjct:    9 FHFYPQDTSKRRSKRSARIKQWLQNNRRVKNVIEQEGFRRQKRGYRNI----------------------NDIEVNM---SDPLFTKQWYLINTGQADGTPGLDLNVAEAWQLGYTGKGVTIAIMDDGIDYLHPDLASNYNADASYDFSSNDPFPFPRYTDDWFNSHGTRCAGEVSAAANNNICGVGVAYNSKVAGIRMLDQPFMTDIIEASSISHMPQTIDIYSASWGPTDDGKTVDGPRELTLQAMADGVNKGRGGKGSIYVWASGDGGSYDDCNCDGYASSMWTISINSAINDGRTALYDESCSSTLASTFSNGRK-RNPEAGVATTDLYGNCTLRHSGTSAAAPEAAGVFALALEANPNLTWRDMQHLSVLTSK--RNQLHDEVHQWRRNGVGLEFNHLFGYGVLDAGGMVKMAKEWKTVPERFHCVAGSIQEPHKIQSGNKLVLAINTEACEGK-DNFVRYLEHVQAVVTVNATRRGDLNINMTSPMGTKSLLLSRRPRDDDSKVGFDKWPFMTTHTWGEDPRGTWVLEVGFQGDQP-QRGVLKEWTVMLHGTQSAPY 541          

Query:  439 LLFLCEYVVCGKIVTNQWHVHLHDPATQESANKVAQETGFSVLRNHLNSPNEFVFHHKTVPHVSSVPSWSQHKVLLAHHLVKNAKQVEGFLRRKRGYKPIKKQGRVPLPTINKKGIPGLGESDNIKVDLKLPTDPLFSKEWYIRNTGQADGVKDLDLNVLSAWAQGITGKGVTTAIMDDGIDYLHPDLSKNYNAESSYDFSSNDPYPFPRYTDDWFNSHGTRCAGEISAERDNGICGVGVAYDSKIAGLRMLDQPYMTDLIEAAAMSYDRDNIDIYSASWGPTDDGRTVDGPRNETMRAIVEGVNKGRKGKGSIYVWASXXXXXXXXXXXXXXXXSMWTISINSATNDGETASYDESCSSTLASTFSNGKAWFSLDAGVGTVDLYGQCTLHHSGTSAAAPEAAGVFALALEANSNIGWRDMQHLTVLTSKXXXXXXXXXXXXWTINGAGLEFNHLFGYGVLDAGDMVRVAKKWVNVPERFHCIAGQIDKRYRFNVTKALILEIDTDACKSDIGHRVNYLEHVQAFVSVKSSRRGDITMFLTSPMGTTSMILSHRPKDDDSTRGFTKWPFMTTHTWGENPRGKWKLTVMFDTKDPLSQGIFSEWVLVLHGTQSRPY 2283
            LLF  E      ++T    V LH+ A Q+ A+++A + GF   R                                    VKN  + EGF R+KRGY+ I                      ++I+V++   +DPLF+K+WY+ NTGQADG   LDLNV  AW  G TGKGVT AIMDDG   L   L+   NA++SYDFSSNDP+PFPRYTDDWFNSHGTRCAGE+SA  +N ICGVGVAY+SK+AG+RMLDQP+MTD+IEA+++S+    IDIYSASWGPTDDG+TVDGPR  T++A+ +GVNKGR GKGSIYVWASGDGG+ DDCNCDGYA+SMWTISINSA NDG TA YDESCSSTLASTFSNG+   + +AGV T DLYG CTL HSGTSAAAPEAAGVFALALEAN N+ WRDMQHL+VLTSK       D  H W  NG GLEFNHLFGYGVLDAG MV++AK+W  VPERFHC+AG I + ++      L+L I+T+AC+    + V YLEHVQA V+V ++RRGD+ + +TSPMGT S++LS RP+DDDS  GF KWPFMTTHTWGE+PRG W L V F    P  +G+  EW ++LHGTQS PY
Sbjct:   20 LLFATE--AAEGVLTEHLLVQLHEDA-QDEAHQLAAQHGFQSARK-----------------------------------VKNVIEQEGFRRQKRGYRNI----------------------NDIEVNM---SDPLFTKQWYLINTGQADGTPGLDLNVAEAWQLGYTGKGVTIAIMDDGEWRLVVTLT---NADASYDFSSNDPFPFPRYTDDWFNSHGTRCAGEVSAAANNNICGVGVAYNSKVAGIRMLDQPFMTDIIEASSISHMPQTIDIYSASWGPTDDGKTVDGPRELTLQAMADGVNKGRGGKGSIYVWASGDGGSYDDCNCDGYASSMWTISINSAINDGRTALYDESCSSTLASTFSNGRK-RNPEAGVATTDLYGNCTLRHSGTSAAAPEAAGVFALALEANPNLTWRDMQHLSVLTSK--RNQLHDEVHQWRRNGVGLEFNHLFGYGVLDAGGMVKMAKEWKTVPERFHCVAGSIQEPHKIQSGNKLVLAINTEACEGK-DNFVRYLEHVQAVVTVNATRRGDLNINMTSPMGTKSLLLSRRPRDDDSKVGFDKWPFMTTHTWGEDPRGTWVLEVGFQGDQP-QRGVLKEWTVMLHGTQSAPY 563          

Query:  484 NQWHVHLHDPATQESANKVAQETGFSVLRNHLNSPNEFVFHHKTVPHVSSVPSWSQHKVLLAHHLVKNAKQVEGFLRRKRGYKPIKKQGRVPLPTINKKGIPGLGESDNIKVDLKLPTDPLFSKEWYIRNTGQADGVKDLDLNVLSAWAQGITGKGVTTAIMDDGIDYLHPDLSKNYNAESSYDFSSNDPYPFPRYTDDWFNSHGTRCAGEISAERDNGICGVGVAYDSKIAGLRMLDQPYMTDLIEAAAMSYDRDNIDIYSASWGPTDDGRTVDGPRNETMRAIVEGVNKGRKGKGSIYVWAS-XXXXXXXXXXXXXXXXSMWTISINSATNDGETASYDESCSSTLASTFSNGKAWFSLDAGVGTVDLYGQCTLHHSGTSAAAPEAAGVFALALEANSNIGWRDMQHLTVLTSKXXXXXXXXXXXXWTINGAGLEFNHLFGYGVLDAGDMVRVA--KKWVNVPERFHCIAGQIDKRYRFNVTKA---LILEIDTDACKSDIGHRVNYLEHVQAFVSVKSSRRGDITMFLTSPMGTTSMILSHRPKDDDSTRGFTKWPFMTTHTWGENPRGKWKLTVMFDTKDPLSQGIFSEWVLVLHGTQSRP 2280
            N+W V +  P    +A  +A+E  + ++R      + ++  H+  PH              A H+ +   + +  L  ++ Y+  +          NK+ +  + E  +  VD KL  DP+++++WY+++T  +  +  LDL+V+  W +GITGKGV   ++DDG+++ H D+  NY+A +SYDF+ NDP PFPRY     N HGTRCAGEI+ + DN  CGVGVAY+SK+ G+RMLD   +TD IEA+++ ++ +++DIYSASWGP DDG+TV+GP     +A   G+ KGR GKGSI+VWAS   G   D+C+CDGY  S++TISI+SA+  G +  Y E CSSTLA+ +S+G      D  + + DL+ +CT  H+GTSA+AP AAG+FALALE N N+ WRD+QH+ V TS+            W  NGAGL  N  FG+G+L+A  +V +A    W +VPE+  CI    D  ++    KA   + +EI T AC     + V  LEH+Q   S++ +RRGD+ + LTSP GTT+++L+ R + D S  GF  W FM+ HTWGE+P G W L +   +    ++G    W L+LHGT  +P
Sbjct:   35 NEWAVEI--PGGLSAAEAIARELDYELVRQIGALDDHYLLKHRRHPH---------RMKRSADHITRQLSEDDRVLWAEQQYEKRR----------NKRAV--IRECRDCSVD-KLFDDPMWNQQWYLQDTRTSSSLPKLDLHVIPVWQKGITGKGVVITVLDDGLEWNHTDIYSNYDAAASYDFNDNDPDPFPRYDSTNENKHGTRCAGEIAMQADNNKCGVGVAYNSKVGGIRMLDG-IVTDAIEASSIGFNPNHVDIYSASWGPNDDGKTVEGPGRLAQKAFEYGIQKGRGGKGSIFVWASGNGGRQGDNCDCDGYTDSIYTISISSASQQGLSPWYAEKCSSTLATAYSSGDY---TDQRITSADLHNECTQTHTGTSASAPLAAGIFALALEQNPNLTWRDLQHIIVWTSE---FDPLANNPGWKRNGAGLMVNSRFGFGLLNAKALVDLADPATWKHVPEKKICIVR--DDSFQPRELKAAGEITIEIPTKACAGQ-ENAVRSLEHLQVEASIEYTRRGDLHITLTSPAGTTTVLLAERER-DTSANGFRNWDFMSVHTWGEDPAGTWTLKITDTSGRMENKGRILSWKLILHGTSEKP 604          

Query:  421 MKITWILLFLCEYVVCGKIVTNQWHVHLHDPATQESANKVAQETGFSVLRNHLNSPNEFVFHHKTVPHVSSVPSWSQHKVLLAHHLVKNAKQVEGFLRRKRGYKPIKKQGRVPLPTINKKGIPGLGESDNIKVDLKLPTDPLFSKEWYIRNTGQADGVKDLDLNVLSAWAQGITGKGVTTAIMDDGIDYLHPDLSKNYNAESSYDFSSNDPYPFPRYTDDWFNSHGTRCAGEISAERDNGICGVGVAYDSKIAGLRMLDQPYMTDLIEAAAMSYDRDNIDIYSASWGPTDDGRTVDGPRNETMRAIVEGVNKGRKGKGSIYVWASXXXXXXXXXXXXXXXXSMWTISINSATNDGETASYDESCSSTLASTFSNGKAWFSLDAGVGTVDLYGQCTLHHSGTSAAAPEAAGVFALALEANSNIGWRDMQHLTVLTSKXXXXXXXXXXXXWTINGAGLEFNHLFGYGVLDAGDMVRVAKKWVNVPERFHCIAGQIDKRYRFNVTKALILEIDTDACKSDIGHRVNYLEHVQAFVSVKSSRRGDITMFLTSPMGTTSMILSHRPKDDDSTRGFTKWPFMTTHTWGENPRGKWKLTVMFDTKDPLSQGIFSEWVLVLHGTQSRPYDKLSSSLEKIIPKLGVVKRQHASNRFSQ 2367
            MKITWILLFLCEYVVCGKIVTNQWHVHLHDPATQESANKVAQETGFSVLRNHLNSPNEFVFHHKTVPHVSSVPSWSQHKVLLAHHLVKNAKQVEGFLRRKRGYKPIKKQGRVPLPTINKKGIPGLGESDNIKVDLKLPTDPLFSKEWYIRNTGQADGVKDLDLNVLSAWAQGITGKGVTTAIMDDGIDYLHPDLSKNYNAESSYDFSSNDPYPFPRYTDDWFNSHGTRCAGEISAERDNGICGVGVAYDSKIAGLRMLDQPYMTDLIEAAAMSYDRDNIDIYSASWGPTDDGRTVDGPRNETMRAIVEGVNKGRKGKGSIYVWASGDGGAADDCNCDGYAASMWTISINSATNDGETASYDESCSSTLASTFSNGKAWFSLDAGVGTVDLYGQCTLHHSGTSAAAPEAAGVFALALEANSNIGWRDMQHLTVLTSKRNHLHDRDRRHNWTINGAGLEFNHLFGYGVLDAGDMVRVAKKWVNVPERFHCIAGQIDKRYRFNVTKALILEIDTDACKSDIGHRVNYLEHVQAFVSVKSSRRGDITMFLTSPMGTTSMILSHRPKDDDSTRGFTKWPFMTTHTWGENPRGKWKLTVMFDTKDPLSQGIFSEWVLVLHGTQSRPYDKLSSSLEKIIPKLGVVKRQHASNRFSQ
Sbjct:    1 MKITWILLFLCEYVVCGKIVTNQWHVHLHDPATQESANKVAQETGFSVLRNHLNSPNEFVFHHKTVPHVSSVPSWSQHKVLLAHHLVKNAKQVEGFLRRKRGYKPIKKQGRVPLPTINKKGIPGLGESDNIKVDLKLPTDPLFSKEWYIRNTGQADGVKDLDLNVLSAWAQGITGKGVTTAIMDDGIDYLHPDLSKNYNAESSYDFSSNDPYPFPRYTDDWFNSHGTRCAGEISAERDNGICGVGVAYDSKIAGLRMLDQPYMTDLIEAAAMSYDRDNIDIYSASWGPTDDGRTVDGPRNETMRAIVEGVNKGRKGKGSIYVWASGDGGAADDCNCDGYAASMWTISINSATNDGETASYDESCSSTLASTFSNGKAWFSLDAGVGTVDLYGQCTLHHSGTSAAAPEAAGVFALALEANSNIGWRDMQHLTVLTSKRNHLHDRDRRHNWTINGAGLEFNHLFGYGVLDAGDMVRVAKKWVNVPERFHCIAGQIDKRYRFNVTKALILEIDTDACKSDIGHRVNYLEHVQAFVSVKSSRRGDITMFLTSPMGTTSMILSHRPKDDDSTRGFTKWPFMTTHTWGENPRGKWKLTVMFDTKDPLSQGIFSEWVLVLHGTQSRPYDKLSSSLEKIIPKLGVVKRQHASNRFSQ 649          

Query:  811 IKVDLKLPTDPLFSKEWYIRNTGQADGVKDLDLNVLSAWAQGITGKGVTTAIMDDGIDYLHPDLSKNYNAESSYDFSSNDPYPFPRY-----TDDWFNSHGTRCAGEISAERDNGICGVGVAYDSKIAGLRMLDQPYMTDLIEAAAMSYDRDNIDIYSASWGPTDDGRTVDGPRNETMRAIVEGVNKGRKGKGSIYVWAS-XXXXXXXXXXXXXXXXSMWTISINSATNDGETASYDESCSSTLASTFSNGKAWFSLDA-GVGTVDLYGQCTLHHSGTSAAAPEAAGVFALALEANSNIGWRDMQHLTVLTSKXXXXXXXXXXXXWTINGAGLEFNHLFGYGVLDAGDMVRVAKKWVNVPERFHC--IAGQIDKRYRFNVTKALILEIDTDACKSDIGHRVNYLEHVQAFVSVKSSRRGDITMFLTSPMGTTSMILSHRPKDDDSTRGFTKWPFMTTHTWGENPRGKWKLTVM-FDTKDPLSQGIFSEWVLVLHGTQSRPYDKLSSSLEK 2310
            ++V   +  DP + K WY+         K+  +N++SAW +G  G+ V  +I+DDGI+  HPDL +NY+  +SYD  SND  P PRY     T    N HGTRCAG+++A  +N ICGVGVAY + I G+RMLD   ++D +E+ ++     +IDIYSASWGP DDG+TVDGP      A  +G+ KGR G GSI+VWAS   G   D+CNCDGY  S++T+ +N+ +  G+   Y E CSSTLA T+S+G    S+D   + T D+  +CT  HSGTSA+AP AAG+ ALAL AN  + WRDMQHL V+T++        R  +W+ N AG E++H FG+G++DAG MV +A  W  VPE+  C  +A               +L I TDAC  +   RV YLEHVQA +S++S++RG++ ++L SP  +TS +L+ R ++D ++ GF  WPFM+ H WGE   G WKLT+  +D +  L       W L+L+GT + P  + +S+  K
Sbjct:   99 VRVKRHIVNDPKWYKMWYLNKMN-----KENSMNIISAWKKGYRGQNVVVSILDDGIEKDHPDLKENYDPNASYDIISNDNNPEPRYISSNNTKIKDNHHGTRCAGQVAATANNRICGVGVAYKANIGGIRMLDGE-VSDSVESHSLRLFYQHIDIYSASWGPEDDGKTVDGPGELAKIAFEDGILKGRNGLGSIFVWASGNGGKNHDNCNCDGYTNSIFTLGVNAVSEIGDAPWYAEKCSSTLAVTYSSG----SMDERAIITTDVNHECTEQHSGTSASAPFAAGICALALSANRFLTWRDMQHLVVITAR----KANLRAVDWSTNAAGKEYSHSFGFGLMDAGAMVDLALNWTTVPEQHICHYVAPMQGGPISLKPYANEVLSITTDACSDNSKKRVRYLEHVQAKISLRSTKRGEVELWLISPSRSTSKLLTKR-RNDVASAGFHHWPFMSVHFWGEEAPGTWKLTIYSYDAEVTLIN-----WSLILYGTDTLPSHRQNSTHTK 588          

Query:  835 TDPLFSKEWYIRNTGQADGVKDLDLNVLSAWAQGITGKGVTTAIMDDGIDYLHPDLSKNYNAESSYDFSS--NDPYPFPRYTDDWFNSHGTRCAGEISAERDNGICGVGVAYDSKIAGLRMLDQPYMTDLIEAAAMSYDRDNIDIYSASWGPTDDGRTVDGPRNETMRAIVEGVNKGRKGKGSIYVWASXXXXXXXXXXXXXXXXSMWTISINSATNDGETAS-YDESCSSTLASTFSNGKAWFSLDAGVGTVDLYGQCTLHHSGTSAAAPEAAGVFALALEANSNIGWRDMQHLTVLTSKXXXXXXXXXXXXWTINGAGLEFNHLFGYGVLDAGDMVRVAKKWVNVPERFHCIAGQIDKRYRFNVTKALILEIDTDACKSDIGHRVNYLEHVQAFVSVKSSRRGDITMFLTSPMGTTSMILSHRPKDDDSTRG---FTKWPFMTTHTWGENPRGKWKLTV-MFDTKDPLSQGIFSEWVLVLHGTQSRPYDKLSS 2298
            +DPLF K+WY+  +      K +D+NV  AW  G TGKGVT +I+DDGIDY H DL +NY+ E+S+D +   NDP P  + T+   N HGTRCAGE+SA+ +N  CGVG+AY+S+I  +RMLD   +TD +EA A+S+ + +IDIYS SWGP D+G+ V+GP      A  +G+  GR G G+IYVWASG+GG   D       AS       S+ ++      Y ESC+STLAST+S+G  +   +  + + DL  +C   H+GTSA+AP AAG+ AL +EANSN+ WRD+Q++ VLTS            N+ +NGA  + ++L+G+G++D+G +VR+ + W  +P    C      K+        + L + TD C     ++VNY+EHV  ++ +   +RGD+ + L SP GT S IL +RP   D  RG   F  WP M+   WGE   G+W + +  + TK   S G++S + L ++GT+  P   +S+
Sbjct:    9 SDPLFKKQWYLIRS--QFNTKLVDMNVKEAWELGYTGKGVTISILDDGIDYRHDDLKENYDPEASFDINGDDNDPLPNLKSTE---NRHGTRCAGEVSAKANNSKCGVGIAYNSRIGAVRMLDGD-VTDRVEAEALSFKQQHIDIYSGSWGPDDNGQKVEGPAILAKSAFKKGIRYGRNGLGNIYVWASGNGGKKSDSCACDGYASSIYTISISSVSENNRKPWYLESCASTLASTYSSGDGY---EQKIISTDLNNKCAFDHTGTSASAPLAAGIIALLIEANSNLTWRDVQYIIVLTSN----PHPFIDGNFIVNGANKKVSNLYGFGLMDSGKLVRIGRLWHKLPSHHFCKISYNGKKISLKDKFTVKLSVKTDGCPGK--NKVNYVEHVILYLKLDYDKRGDLRIILISPSGTRSEILPYRPH--DFARGPSTFDIWPLMSVQFWGEKASGEWSVEINNYGTKFSKSNGVWSNFELKIYGTEKWPIRLISA 486          

Query:  907 LNVLSAWAQGITGKGVTTAIMDDGIDYLHPDLSKNYNAESSYDFSS--NDPYPFPRYTDDWFNSHGTRCAGEISAERDNGICGVGVAYDSKIAGLRMLDQPYMTDLIEAAAMSYDRDNIDIYSASWGPTDDGRTVDGPRNETMRAIVEGVNKGRKGKGSIYVWASXXXXXXXXXXXXXXXXSMWTISINSATNDGETAS-YDESCSSTLASTFSNGKAWFSLDAGVGTVDLYGQCTLHHSGTSAAAPEAAGVFALALEANSNIGWRDMQHLTVLTSKXXXXXXXXXXXXWTINGAGLEFNHLFGYGVLDAGDMVRVAKKWVNVPERFHCIAGQIDKRYRFNVTKALILEIDTDACKSDIGHRVNYLEHVQAFVSVKSSRRGDITMFLTSPMGTTSMILSHRPKDDDSTRG---FTKWPFMTTHTWGENPRGKWKLTV-MFDTKDPLSQGIFSEWVLVLHGTQSRPYDKLSS 2298
            +NV  AW  G TGKGVT +I+DDGIDY H DL +NY+ E+S+D +   NDP P  + T+   N HGTRCAGE+SA+ +N  CGVG+AY+S+I  +RMLD   +TD +EA A+S+ + +IDIYS SWGP D+G+ V+GP      A  +G+  GR G G+IYVWASG+GG   D       AS       S+ ++      Y ESC+STLAST+S+G  +   +  + + DL  +C   H+GTSA+AP AAG+ AL +EANSN+ WRD+Q++ VLTS            N+ +NGA  + ++L+G+G++D+G +VR+ + W  +P    C      K+        + L + TD C     ++VNY+EHV  ++ +   +RGD+ + L SP GT S IL +RP   D  RG   F  WP M+   WGE   G+W + +  + TK   S G++S + L ++GT+  P   +S+
Sbjct:    1 MNVKEAWELGYTGKGVTISILDDGIDYRHDDLKENYDPEASFDINGDDNDPLPNLKSTE---NRHGTRCAGEVSAKANNSKCGVGIAYNSRIGAVRMLDGD-VTDRVEAEALSFKQQHIDIYSGSWGPDDNGQKVEGPAILAKSAFKKGIRYGRNGLGNIYVWASGNGGKKSDSCACDGYASSIYTISISSVSENNRKPWYLESCASTLASTYSSGDGY---EQKIISTDLNNKCAFDHTGTSASAPLAAGIIALLIEANSNLTWRDVQYIIVLTSN----PHPFIDGNFIVNGANKKVSNLYGFGLMDSGKLVRIGRLWHKLPSHHFCKISYNGKKISLKDKFTVKLSVKTDGCPGK--NKVNYVEHVILYLKLDYDKRGDLRIILISPSGTRSEILPYRPH--DFARGPSTFDIWPLMSVQFWGEKASGEWSVEINNYGTKFSKSNGVWSNFELKIYGTEKWPIRLISA 456          

Query:  907 LNVLSAWAQGITGKGVTTAIMDDGIDYLHPDLSKNYNAESSYDFSS--NDPYPFPRYTDDWFNSHGTRCAGEISAERDNGICGVGVAYDSKIAGLRMLDQPYMTDLIEAAAMSYDRDNIDIYSASWGPTDDGRTVDGPRNETMRAIVEGVNKGRKGKGSIYVWASXXXXXXXXXXXXXXXXSMWTISINSATNDGETAS-YDESCSSTLASTFSNGKAWFSLDAGVGTVDLYGQCTLHHSGTSAAAPEAAGVFALALEANSNIGWRDMQHLTVLTSKXXXXXXXXXXXXWTINGAGLEFNHLFGYGVLDAGDMVRVAKKWVNVPERFHCIAGQIDKRYRFNVTKALILEIDTDACKSDIGHRVNYLEHVQAFVSVKSSRRGDITMFLTSPMGTTSMILSHRPKDDDSTRG---FTKWPFMTTHTWGENPRGKWKLTV-MFDTKDPLSQGIFSEWVLVLHGTQSRPYDKLSS 2298
            +NV  AW  G TGKGVT +I+DDGIDY H DL +NY+ E+S+D +   NDP P  + T+   N HGTRCAGE+SA+ +N  CGVG+AY+S+I  +RMLD   +TD +EA A+S+ + +IDIYS SWGP D+G+ V+GP      A  +G+  GR G G+IYVWASG+GG   D       AS       S+ ++      Y ESC+STLAST+S+G  +   +  + + DL  +C   H+GTSA+AP AAG+ AL +EANSN+ WRD+Q++ VLTS            N+ +NGA  + ++L+G+G++D+G +VR+ + W  +P    C      K+        + L + TD C     ++VNY+EHV  ++ +   +RGD+ + L SP GT S IL +RP   D  RG   F  WP M+   WGE   G+W + +  + TK   S G++S + L ++GT+  P   +S+
Sbjct:    1 MNVKEAWELGYTGKGVTISILDDGIDYRHDDLKENYDPEASFDINGDDNDPLPNLKSTE---NRHGTRCAGEVSAKANNSKCGVGIAYNSRIGAVRMLDGD-VTDRVEAEALSFKQQHIDIYSGSWGPDDNGQKVEGPAILAKSAFKKGIRYGRNGLGNIYVWASGNGGKKSDSCACDGYASSIYTISISSVSENNRKPWYLESCASTLASTYSSGDGY---EQKIISTDLNNKCAFDHTGTSASAPLAAGIIALLIEANSNLTWRDVQYIIVLTSN----PHPFIDGNFIVNGANKKVSNLYGFGLMDSGKLVRIGRLWHKLPSHHFCKISYNGKKISLKDKFTVKLSVKTDGCPGK--NKVNYVEHVILYLKLDYDKRGDLRIILISPSGTRSEILPYRPH--DFARGPSTFDIWPLMSVQFWGEKASGEWSVEINNYGTKFSKSNGVWSNFELKIYGTEKWPIRLISA 456