2-oxoisovalerate dehydrogenase subunit alpha
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Overview
Neoblast Clusters
Zeng et. al., 2018▻ Overview▻ Neoblast Population▻ Sub-lethal Irradiated Surviving X1 and X2 Cell Population
Overview
Single cell RNA-seq of pluripotent neoblasts and its early progeniesWe isolated X1 neoblasts cells enriched in high piwi-1 expression (Neoblast Population), and profiled ∼7,614 individual cells via scRNA-seq. Unsupervised analyses uncovered 12 distinct classes from 7,088 high-quality cells. We designated these classes Nb1 to Nb12 and ordered them based on high (Nb1) to low (Nb12) piwi-1 expression levels. We further defined groups of genes that best classified the cells parsed into 12 distinct cell clusters to generate a scaled expression heat map of discriminative gene sets for each cluster. Expression of each cluster’s gene signatures was validated using multiplex fluorescence in situ hybridization (FISH) co-stained with piwi-1 and largely confirmed the cell clusters revealed by scRNA-seq.We also tested sub-lethal irradiation exposure. To profile rare pluripotent stem cells (PSCs) and avoid interference from immediate progenitor cells, we determined a time point after sub-lethal irradiation (7 DPI) with minimal piwi-1+ cells, followed by isolation and single-cell RNA-seq of 1,200 individual cells derived from X1 (Piwi-1 high) and X2 (Piwi-1 low) cell populations (Sub-lethal Irradiated Surviving X1 and X2 Cell Population)Explore this single cell expression dataset with our NB Cluster Shiny App
Neoblast Population
Sub-lethal Irradiated Surviving X1 and X2 Cell Population
Embryonic Expression
Davies et. al., 2017
Hover the mouse over a column in the graph to view average RPKM values per sample. Embryonic Stages: Y: yolk. S2-S8: Stages 2-8. C4: asexual adult. SX: virgin, sexually mature adult. back to top Anatomical Expression
PAGE et. al., 2020SMED30010036 has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGEPAGE Curations: 7
Homology
BLAST of 2-oxoisovalerate dehydrogenase subunit alpha vs. Ensembl Human
Match: BCKDHA (branched chain keto acid dehydrogenase E1 subunit alpha [Source:HGNC Symbol;Acc:HGNC:986]) HSP 1 Score: 450.284 bits (1157), Expect = 1.098e-144 Identity = 236/393 (60.05%), Postives = 293/393 (74.55%), Query Frame = 2
Query: 125 DKPNFPQSRSEYTSQLNFIYPTDIKGIPLYRVLDGNGNLREDGLDPXXXXXXXXXXXXTMTLLNTMDRILYDSQRQGRISFYMTHYGEEGVQIGSAAALNDGDLIFGQYREAGVGLWRGFTLEEMLNQCYGNKYDSNKGKQMPIHYANKKLNYFSISSVLGTQMPHAVGAAYAFKRAQNGKCVICYFGDGASSVGDAHAALNFSATLDCPVIMLCRNNLYAISTPVHEQXXXXXXXXXXXXXXXATIRVDGNDLIAVYNATKAARELCVNENRPVLIEAMTYRIGSHSTSDDSLAYRSVDEVTWWDKHDNPILRFKFYLKQKNWWSDKEEEAWRNESRKLVVQAIEKAEKTNLPNPLILFEDVYDEMPTRIRSQMNKHYTFLKRNKEHYPISY 1303
DKP FP + +E+ +L FI P I GIP+YRV+D G + DP KE +K+ K+MTLLNTMDRILY+SQRQGRISFYMT+YGEEG +GSAAAL++ DL+FGQYREAGV ++R + LE + QCYGN D KG+QMP+HY K+ ++ +ISS L TQ+P AVGAAYA KRA + VICYFG+GA+S GDAHA NF+ATL+CP+I CRNN YAISTP EQYRGDGI +RG GYGI +IRVDGND+ AVYNATK AR V EN+P LIEAMTYRIG HSTSDDS AYRSVDEV +WDK D+PI R + YL + WW +++E+AWR +SR+ V++A E+AE+ PNP +LF DVY EMP ++R Q L+ EHYP+ +
Sbjct: 50 DKPQFPGASAEFIDKLEFIQPNVISGIPIYRVMDRQGQIINPSEDPHLPKEKVLKLYKSMTLLNTMDRILYESQRQGRISFYMTNYGEEGTHVGSAAALDNTDLVFGQYREAGVLMYRDYPLELFMAQCYGNISDLGKGRQMPVHYGCKERHFVTISSPLATQIPQAVGAAYAAKRANANRVVICYFGEGAASEGDAHAGFNFAATLECPIIFFCRNNGYAISTPTSEQYRGDGIAARGPGYGIMSIRVDGNDVFAVYNATKEARRRAVAENQPFLIEAMTYRIGHHSTSDDSSAYRSVDEVNYWDKQDHPISRLRHYLLSQGWWDEEQEKAWRKQSRRKVMEAFEQAERKPKPNPNLLFSDVYQEMPAQLRKQQESLARHLQTYGEHYPLDH 442
BLAST of 2-oxoisovalerate dehydrogenase subunit alpha vs. Ensembl Human
Match: AC011462.1 (novel protein) HSP 1 Score: 451.055 bits (1159), Expect = 2.034e-144 Identity = 236/393 (60.05%), Postives = 293/393 (74.55%), Query Frame = 2
Query: 125 DKPNFPQSRSEYTSQLNFIYPTDIKGIPLYRVLDGNGNLREDGLDPXXXXXXXXXXXXTMTLLNTMDRILYDSQRQGRISFYMTHYGEEGVQIGSAAALNDGDLIFGQYREAGVGLWRGFTLEEMLNQCYGNKYDSNKGKQMPIHYANKKLNYFSISSVLGTQMPHAVGAAYAFKRAQNGKCVICYFGDGASSVGDAHAALNFSATLDCPVIMLCRNNLYAISTPVHEQXXXXXXXXXXXXXXXATIRVDGNDLIAVYNATKAARELCVNENRPVLIEAMTYRIGSHSTSDDSLAYRSVDEVTWWDKHDNPILRFKFYLKQKNWWSDKEEEAWRNESRKLVVQAIEKAEKTNLPNPLILFEDVYDEMPTRIRSQMNKHYTFLKRNKEHYPISY 1303
DKP FP + +E+ +L FI P I GIP+YRV+D G + DP KE +K+ K+MTLLNTMDRILY+SQRQGRISFYMT+YGEEG +GSAAAL++ DL+FGQYREAGV ++R + LE + QCYGN D KG+QMP+HY K+ ++ +ISS L TQ+P AVGAAYA KRA + VICYFG+GA+S GDAHA NF+ATL+CP+I CRNN YAISTP EQYRGDGI +RG GYGI +IRVDGND+ AVYNATK AR V EN+P LIEAMTYRIG HSTSDDS AYRSVDEV +WDK D+PI R + YL + WW +++E+AWR +SR+ V++A E+AE+ PNP +LF DVY EMP ++R Q L+ EHYP+ +
Sbjct: 84 DKPQFPGASAEFIDKLEFIQPNVISGIPIYRVMDRQGQIINPSEDPHLPKEKVLKLYKSMTLLNTMDRILYESQRQGRISFYMTNYGEEGTHVGSAAALDNTDLVFGQYREAGVLMYRDYPLELFMAQCYGNISDLGKGRQMPVHYGCKERHFVTISSPLATQIPQAVGAAYAAKRANANRVVICYFGEGAASEGDAHAGFNFAATLECPIIFFCRNNGYAISTPTSEQYRGDGIAARGPGYGIMSIRVDGNDVFAVYNATKEARRRAVAENQPFLIEAMTYRIGHHSTSDDSSAYRSVDEVNYWDKQDHPISRLRHYLLSQGWWDEEQEKAWRKQSRRKVMEAFEQAERKPKPNPNLLFSDVYQEMPAQLRKQQESLARHLQTYGEHYPLDH 476
BLAST of 2-oxoisovalerate dehydrogenase subunit alpha vs. Ensembl Human
Match: BCKDHA (branched chain keto acid dehydrogenase E1 subunit alpha [Source:HGNC Symbol;Acc:HGNC:986]) HSP 1 Score: 435.647 bits (1119), Expect = 4.209e-139 Identity = 236/418 (56.46%), Postives = 293/418 (70.10%), Query Frame = 2
Query: 125 DKPNFPQSRSEYTSQLNFIYPTDIKGIPLYRVLDGNGNLREDGLDPXXXXXXXXXXXXTMTLLNTMDRILYDSQRQGRISFYMTHYGEEGVQIGSAAALNDGDLIFGQYREAGVGLWRGFTLEEMLNQCYGNKYDSNKGKQMPIHYANKKLNYFSISSVLGTQMPHAVGAAYAFKRAQNGKCVICYFGDGASSVGDAHAALNFSATLDCPVIMLCRNNLYAISTPVHEQXXXXXXXXXXXXXXXATIRVDGNDLIAVYNATKAARELCVNENRPVLIEAMTY-------------------------RIGSHSTSDDSLAYRSVDEVTWWDKHDNPILRFKFYLKQKNWWSDKEEEAWRNESRKLVVQAIEKAEKTNLPNPLILFEDVYDEMPTRIRSQMNKHYTFLKRNKEHYPISY 1303
DKP FP + +E+ +L FI P I GIP+YRV+D G + DP KE +K+ K+MTLLNTMDRILY+SQRQGRISFYMT+YGEEG +GSAAAL++ DL+FGQYREAGV ++R + LE + QCYGN D KG+QMP+HY K+ ++ +ISS L TQ+P AVGAAYA KRA + VICYFG+GA+S GDAHA NF+ATL+CP+I CRNN YAISTP EQYRGDGI +RG GYGI +IRVDGND+ AVYNATK AR V EN+P LIEAMTY RIG HSTSDDS AYRSVDEV +WDK D+PI R + YL + WW +++E+AWR +SR+ V++A E+AE+ PNP +LF DVY EMP ++R Q L+ EHYP+ +
Sbjct: 28 DKPQFPGASAEFIDKLEFIQPNVISGIPIYRVMDRQGQIINPSEDPHLPKEKVLKLYKSMTLLNTMDRILYESQRQGRISFYMTNYGEEGTHVGSAAALDNTDLVFGQYREAGVLMYRDYPLELFMAQCYGNISDLGKGRQMPVHYGCKERHFVTISSPLATQIPQAVGAAYAAKRANANRVVICYFGEGAASEGDAHAGFNFAATLECPIIFFCRNNGYAISTPTSEQYRGDGIAARGPGYGIMSIRVDGNDVFAVYNATKEARRRAVAENQPFLIEAMTYSSSPILPPDPHSREPTLTWGPLPLCRIGHHSTSDDSSAYRSVDEVNYWDKQDHPISRLRHYLLSQGWWDEEQEKAWRKQSRRKVMEAFEQAERKPKPNPNLLFSDVYQEMPAQLRKQQESLARHLQTYGEHYPLDH 445
BLAST of 2-oxoisovalerate dehydrogenase subunit alpha vs. Ensembl Human
Match: BCKDHA (branched chain keto acid dehydrogenase E1 subunit alpha [Source:HGNC Symbol;Acc:HGNC:986]) HSP 1 Score: 320.472 bits (820), Expect = 1.959e-98 Identity = 179/308 (58.12%), Postives = 213/308 (69.16%), Query Frame = 2
Query: 125 DKPNFPQSRSEYTSQLNFIYPTDIKGIPLYRVLDGNGNLREDGLDPXXXXXXXXXXXXTMTLLNTMDRILYDSQRQGRISFYMTHYGEEGVQIGSAAALNDGDLIFGQYREAGVGLWRGFTLEEMLNQCYGNKYDSNKGKQMPIHYANKKLNYFSISSVLGTQMPHAVGAAYAFKRAQNGKCVICYFGDGASSVGDAHAALNFSATLDCPVIMLCRNNLYAISTPVHEQXXXXXXXXXXXXXXXATIRVDGNDLIAVYNATKAARELCVNENRPVLIEAMTYRIGSHSTSDDSLAYRSVDEVTWWDKH 1048
DKP FP + +E+ +L FI P I GIP+YRV+D G + DP GRISFYMT+YGEEG +GSAAAL++ DL+FGQYREAGV ++R + LE + QCYGN D KG+QMP+HY K+ ++ +ISS L TQ+P AVGAAYA KRA + VICYFG+GA+S GDAHA NF+ATL+CP+I CRNN YAISTP EQYRGDGI +RG GYGI +IRVDGND+ AVYNATK AR V EN+P LIEAMTYRIG HSTSDDS AYRSVDEV +WDK
Sbjct: 50 DKPQFPGASAEFIDKLEFIQPNVISGIPIYRVMDRQGQIINPSEDP-----------------------------HGRISFYMTNYGEEGTHVGSAAALDNTDLVFGQYREAGVLMYRDYPLELFMAQCYGNISDLGKGRQMPVHYGCKERHFVTISSPLATQIPQAVGAAYAAKRANANRVVICYFGEGAASEGDAHAGFNFAATLECPIIFFCRNNGYAISTPTSEQYRGDGIAARGPGYGIMSIRVDGNDVFAVYNATKEARRRAVAENQPFLIEAMTYRIGHHSTSDDSSAYRSVDEVNYWDKQ 328
BLAST of 2-oxoisovalerate dehydrogenase subunit alpha vs. Ensembl Human
Match: BCKDHA (branched chain keto acid dehydrogenase E1 subunit alpha [Source:HGNC Symbol;Acc:HGNC:986]) HSP 1 Score: 186.808 bits (473), Expect = 4.358e-53 Identity = 108/209 (51.67%), Postives = 134/209 (64.11%), Query Frame = 2
Query: 176 FIYPTDIKGIPLYRVLDGNGNLREDGLDPXXXXXXXXXXXXTMTLLNTMDRILYDSQRQGRISFYMTHYGEEGVQIGSAAALNDGDLIFGQYREA-------------------------------GVGLWRGFTLEEMLNQCYGNKYDSNKGKQMPIHYANKKLNYFSISSVLGTQMPHAVGAAYAFKRAQNGKCVICYFGDGASSVG 709
FI P I GIP+YRV+D G + DP KE +K+ K+MTLLNTMDRILY+SQRQGRISFYMT+YGEEG +GSAAAL++ DL+FGQYREA GV ++R + LE + QCYGN D KG+QMP+HY K+ ++ +ISS L TQ+P AVGAAYA KRA + VICYFG+GA+S G
Sbjct: 3 FIQPNVISGIPIYRVMDRQGQIINPSEDPHLPKEKVLKLYKSMTLLNTMDRILYESQRQGRISFYMTNYGEEGTHVGSAAALDNTDLVFGQYREAEARPHHVAQAGLQLLGSSDPPTSASQSAGITGVLMYRDYPLELFMAQCYGNISDLGKGRQMPVHYGCKERHFVTISSPLATQIPQAVGAAYAAKRANANRVVICYFGEGAASEG 211
BLAST of 2-oxoisovalerate dehydrogenase subunit alpha vs. Ensembl Celegans
Match: bckd-1A (2-oxoisovalerate dehydrogenase subunit alpha, mitochondrial [Source:UniProtKB/Swiss-Prot;Acc:O45924]) HSP 1 Score: 422.165 bits (1084), Expect = 9.322e-135 Identity = 217/384 (56.51%), Postives = 277/384 (72.14%), Query Frame = 2
Query: 149 RSEYTSQLNFIYPTDIKGIPLYRVLDGNGNLREDGLDPXXXXXXXXXXXXTMTLLNTMDRILYDSQRQGRISFYMTHYGEEGVQIGSAAALNDGDLIFGQYREAGVGLWRGFTLEEMLNQCYGNKYDSNKGKQMPIHYANKKLNYFSISSVLGTQMPHAVGAAYAFKRAQ-NGKCVICYFGDGASSVGDAHAALNFSATLDCPVIMLCRNNLYAISTPVHEQXXXXXXXXXXXXXXXATIRVDGNDLIAVYNATKAARELCVNENRPVLIEAMTYRIGSHSTSDDSLAYRSVDEVTWWDKHDNPILRFKFYLKQKNWWSDKEEEAWRNESRKLVVQAIEKAEKTNLPNPLILFEDVYDEMPTRIRSQMNKHYTFLKRNKEHYPI 1297
++ +T +L + D +P+YRV + G++ + DP F ++ S+K+ KTMT LN MDRILYDSQRQGRISFYMT +GEEG +GSAAAL DLI+GQYREAGV LWRG+T+E +NQCYGN D KG+QMP+H+ K+ N+ +ISS L TQ+P AVG+AYAFK+ + N + + YFGDGA+S GDAHAA NF+ATL CP+I CRNN YAISTP EQY GDGI +G YG+ TIRVDGNDL+AVYNATK AR + + NRPVLIEAMTYR+G HSTSDDS AYRS DEV W D+PI RFK Y+ ++ WW++++E W+ E +K V+ AEK + LFEDVYDE+P R+R Q ++ + KEHYP+
Sbjct: 42 KAAFTEKLEIVNADDTPALPIYRVTNAVGDVIDKSQDPNFDEQTSLKMYKTMTQLNIMDRILYDSQRQGRISFYMTSFGEEGNHVGSAAALEPQDLIYGQYREAGVLLWRGYTMENFMNQCYGNADDLGKGRQMPMHFGTKERNFVTISSPLTTQLPQAVGSAYAFKQQKDNNRIAVVYFGDGAASEGDAHAAFNFAATLKCPIIFFCRNNGYAISTPTSEQYGGDGIAGKGPAYGLHTIRVDGNDLLAVYNATKEARRVALT-NRPVLIEAMTYRLGHHSTSDDSTAYRSSDEVQTWGDKDHPITRFKKYITERGWWNEEKEMEWQKEVKKRVLTEFAAAEKRKKAHYHDLFEDVYDELPLRLRRQRDELDAHVAEYKEHYPM 424
BLAST of 2-oxoisovalerate dehydrogenase subunit alpha vs. Ensembl Celegans
Match: bckd-1A (2-oxoisovalerate dehydrogenase subunit alpha, mitochondrial [Source:UniProtKB/Swiss-Prot;Acc:O45924]) HSP 1 Score: 422.165 bits (1084), Expect = 9.996e-135 Identity = 217/384 (56.51%), Postives = 277/384 (72.14%), Query Frame = 2
Query: 149 RSEYTSQLNFIYPTDIKGIPLYRVLDGNGNLREDGLDPXXXXXXXXXXXXTMTLLNTMDRILYDSQRQGRISFYMTHYGEEGVQIGSAAALNDGDLIFGQYREAGVGLWRGFTLEEMLNQCYGNKYDSNKGKQMPIHYANKKLNYFSISSVLGTQMPHAVGAAYAFKRAQ-NGKCVICYFGDGASSVGDAHAALNFSATLDCPVIMLCRNNLYAISTPVHEQXXXXXXXXXXXXXXXATIRVDGNDLIAVYNATKAARELCVNENRPVLIEAMTYRIGSHSTSDDSLAYRSVDEVTWWDKHDNPILRFKFYLKQKNWWSDKEEEAWRNESRKLVVQAIEKAEKTNLPNPLILFEDVYDEMPTRIRSQMNKHYTFLKRNKEHYPI 1297
++ +T +L + D +P+YRV + G++ + DP F ++ S+K+ KTMT LN MDRILYDSQRQGRISFYMT +GEEG +GSAAAL DLI+GQYREAGV LWRG+T+E +NQCYGN D KG+QMP+H+ K+ N+ +ISS L TQ+P AVG+AYAFK+ + N + + YFGDGA+S GDAHAA NF+ATL CP+I CRNN YAISTP EQY GDGI +G YG+ TIRVDGNDL+AVYNATK AR + + NRPVLIEAMTYR+G HSTSDDS AYRS DEV W D+PI RFK Y+ ++ WW++++E W+ E +K V+ AEK + LFEDVYDE+P R+R Q ++ + KEHYP+
Sbjct: 41 KAAFTEKLEIVNADDTPALPIYRVTNAVGDVIDKSQDPNFDEQTSLKMYKTMTQLNIMDRILYDSQRQGRISFYMTSFGEEGNHVGSAAALEPQDLIYGQYREAGVLLWRGYTMENFMNQCYGNADDLGKGRQMPMHFGTKERNFVTISSPLTTQLPQAVGSAYAFKQQKDNNRIAVVYFGDGAASEGDAHAAFNFAATLKCPIIFFCRNNGYAISTPTSEQYGGDGIAGKGPAYGLHTIRVDGNDLLAVYNATKEARRVALT-NRPVLIEAMTYRLGHHSTSDDSTAYRSSDEVQTWGDKDHPITRFKKYITERGWWNEEKEMEWQKEVKKRVLTEFAAAEKRKKAHYHDLFEDVYDELPLRLRRQRDELDAHVAEYKEHYPM 423
BLAST of 2-oxoisovalerate dehydrogenase subunit alpha vs. Ensembl Celegans
Match: pdha-1 (Probable pyruvate dehydrogenase E1 component subunit alpha, mitochondrial [Source:UniProtKB/Swiss-Prot;Acc:P52899]) HSP 1 Score: 136.346 bits (342), Expect = 4.832e-34 Identity = 94/313 (30.03%), Postives = 151/313 (48.24%), Query Frame = 2
Query: 302 MTLLNTMDRILYDSQRQGRI-SFYMTHYGEEGVQIGSAAALNDGDLIFGQYREAGVGLWRGFTLEEMLNQCYGNKYDSNKGKQMPIHYANKKLNYFSISSVLGTQMPHAVGAAYAFK-RAQNGKCVICYFGDGASSVGDAHAALNFSATLDCPVIMLCRNNLYAISTPVHEQXXXXXXXXXXXXXXXATIRVDGNDLIAVYNATKAARELCVNENRPVLIEAMTYRIGSHSTSDDSLAYRSVDEVTWWDKHDNPILRFKFYLKQKNWWSDKEEEAWRNESRKLVVQAIEKAEKTNLPNPLILFEDVYDEMPTR 1234
M ++ M+ + ++ +I F + G+E +G AA+ +GD + YR G G T+ E+L + G + GK +H K N++ + ++G Q P G A A K R Q CV Y GDGA++ G A N + D PV+ +C NN + + T + G + I VDG D++AV ATK A+E C + P+++E TYR HS SD +YR+ +E+ K +PI FK + + +++E +A E RK V +A++ A + P L+ D+Y P +
Sbjct: 62 MQVIRRMESAAGNLYKEKKIRGFCHLYSGQEACAVGMKAAMTEGDAVITAYRCHGWTWLLGATVTEVLAELTGRVAGNVHGKGGSMHMYTK--NFYGGNGIVGAQQPLGAGVALAMKYREQKNVCVTLY-GDGAANQGQLFEATNMAKLWDLPVLFVCENNGFGMGTTA--ERSSASTEYYTRGDYVPGIWVDGMDILAVREATKWAKEYCDSGKGPLMMEMATYRYHGHSMSDPGTSYRTREEIQEVRKTRDPITGFKDRIITSSLATEEELKAIDKEVRKEVDEALKIATSDGVLPPEALYADIYHNTPAQ 369
BLAST of 2-oxoisovalerate dehydrogenase subunit alpha vs. Ensembl Celegans
Match: pdha-1 (Probable pyruvate dehydrogenase E1 component subunit alpha, mitochondrial [Source:UniProtKB/Swiss-Prot;Acc:P52899]) HSP 1 Score: 136.346 bits (342), Expect = 4.832e-34 Identity = 94/313 (30.03%), Postives = 151/313 (48.24%), Query Frame = 2
Query: 302 MTLLNTMDRILYDSQRQGRI-SFYMTHYGEEGVQIGSAAALNDGDLIFGQYREAGVGLWRGFTLEEMLNQCYGNKYDSNKGKQMPIHYANKKLNYFSISSVLGTQMPHAVGAAYAFK-RAQNGKCVICYFGDGASSVGDAHAALNFSATLDCPVIMLCRNNLYAISTPVHEQXXXXXXXXXXXXXXXATIRVDGNDLIAVYNATKAARELCVNENRPVLIEAMTYRIGSHSTSDDSLAYRSVDEVTWWDKHDNPILRFKFYLKQKNWWSDKEEEAWRNESRKLVVQAIEKAEKTNLPNPLILFEDVYDEMPTR 1234
M ++ M+ + ++ +I F + G+E +G AA+ +GD + YR G G T+ E+L + G + GK +H K N++ + ++G Q P G A A K R Q CV Y GDGA++ G A N + D PV+ +C NN + + T + G + I VDG D++AV ATK A+E C + P+++E TYR HS SD +YR+ +E+ K +PI FK + + +++E +A E RK V +A++ A + P L+ D+Y P +
Sbjct: 62 MQVIRRMESAAGNLYKEKKIRGFCHLYSGQEACAVGMKAAMTEGDAVITAYRCHGWTWLLGATVTEVLAELTGRVAGNVHGKGGSMHMYTK--NFYGGNGIVGAQQPLGAGVALAMKYREQKNVCVTLY-GDGAANQGQLFEATNMAKLWDLPVLFVCENNGFGMGTTA--ERSSASTEYYTRGDYVPGIWVDGMDILAVREATKWAKEYCDSGKGPLMMEMATYRYHGHSMSDPGTSYRTREEIQEVRKTRDPITGFKDRIITSSLATEEELKAIDKEVRKEVDEALKIATSDGVLPPEALYADIYHNTPAQ 369
BLAST of 2-oxoisovalerate dehydrogenase subunit alpha vs. Ensembl Celegans
Match: pdha-1 (Probable pyruvate dehydrogenase E1 component subunit alpha, mitochondrial [Source:UniProtKB/Swiss-Prot;Acc:P52899]) HSP 1 Score: 136.346 bits (342), Expect = 4.832e-34 Identity = 94/313 (30.03%), Postives = 151/313 (48.24%), Query Frame = 2
Query: 302 MTLLNTMDRILYDSQRQGRI-SFYMTHYGEEGVQIGSAAALNDGDLIFGQYREAGVGLWRGFTLEEMLNQCYGNKYDSNKGKQMPIHYANKKLNYFSISSVLGTQMPHAVGAAYAFK-RAQNGKCVICYFGDGASSVGDAHAALNFSATLDCPVIMLCRNNLYAISTPVHEQXXXXXXXXXXXXXXXATIRVDGNDLIAVYNATKAARELCVNENRPVLIEAMTYRIGSHSTSDDSLAYRSVDEVTWWDKHDNPILRFKFYLKQKNWWSDKEEEAWRNESRKLVVQAIEKAEKTNLPNPLILFEDVYDEMPTR 1234
M ++ M+ + ++ +I F + G+E +G AA+ +GD + YR G G T+ E+L + G + GK +H K N++ + ++G Q P G A A K R Q CV Y GDGA++ G A N + D PV+ +C NN + + T + G + I VDG D++AV ATK A+E C + P+++E TYR HS SD +YR+ +E+ K +PI FK + + +++E +A E RK V +A++ A + P L+ D+Y P +
Sbjct: 62 MQVIRRMESAAGNLYKEKKIRGFCHLYSGQEACAVGMKAAMTEGDAVITAYRCHGWTWLLGATVTEVLAELTGRVAGNVHGKGGSMHMYTK--NFYGGNGIVGAQQPLGAGVALAMKYREQKNVCVTLY-GDGAANQGQLFEATNMAKLWDLPVLFVCENNGFGMGTTA--ERSSASTEYYTRGDYVPGIWVDGMDILAVREATKWAKEYCDSGKGPLMMEMATYRYHGHSMSDPGTSYRTREEIQEVRKTRDPITGFKDRIITSSLATEEELKAIDKEVRKEVDEALKIATSDGVLPPEALYADIYHNTPAQ 369
BLAST of 2-oxoisovalerate dehydrogenase subunit alpha vs. Ensembl Fly
Match: CG8199 (gene:FBgn0037709 transcript:FBtr0082067) HSP 1 Score: 414.846 bits (1065), Expect = 7.709e-132 Identity = 211/398 (53.02%), Postives = 279/398 (70.10%), Query Frame = 2
Query: 119 SADKPNFPQSRSEYTSQLNFIYPTDIKGIPLYRVLDGNGNLREDGLDPXXXXXXXXXXXXTMTLLNTMDRILYDSQRQGRISFYMTHYGEEGVQIGSAAALNDGDLIFGQYREAGVGLWRGFTLEEMLNQCYGNKYDSNKGKQMPIHYANKKLNYFSISSVLGTQMPHAVGAAYAFK-RAQNGKCVICYFGDGASSVGDAHAALNFSATLDCPVIMLCRNNLYAISTPVHEQ-XXXXXXXXXXXXXXXATIRVDGNDLIAVYNATKAARELCVNENRPVLIEAMTYRIGSHSTSDDSLAYRSVDEVTWWDKHDNPILRFKFYLKQKNWWSDKEEEAWRNESRKLVVQAIEKAEKTNLPNPLILFEDVYDEMPTRI---RSQMNKHYTFLKRNKEHYPI 1297
S D NFP +++ + S+LN I P D IP+YRV+D +G + ++ DP+ +E K+ + M LLNTMD+ILY+SQRQGRISFYMT++GEE IGSAAAL DLI+GQYREAGV +WRGF +++ ++QCYGN D +GKQMP+HY +++LN+ +ISS L TQMP AVGAAYA K R N CV+CYFG+GA+S GDAHAA NF+ATL CP I+ CRNN +AISTP HEQ G +GYGI TIRVDG D+ AVYNA KAARE + EN+PV+ EA+ YR+G HSTSDDS AYR +E+ W+ ++PI + K Y+ K W+ + E + + RK V++ I +EK PN +FE VY EMP + RS++ KH ++ +KEHYP+
Sbjct: 40 SEDYANFPGAKAPFVSKLNLIQPEDYAPIPIYRVMDQDGYIADETQDPQLGREVVEKMFRDMVLLNTMDKILYESQRQGRISFYMTNFGEEASHIGSAAALEMRDLIYGQYREAGVLVWRGFRIDQFIDQCYGNTDDLGRGKQMPVHYGSRELNFVTISSPLSTQMPQAVGAAYAMKLRPNNDACVVCYFGEGAASEGDAHAAFNFAATLGCPAILFCRNNGFAISTPSHEQYKGDGIAGRGPMGYGITTIRVDGTDVFAVYNAMKAAREYVLKENKPVVFEALAYRVGHHSTSDDSTAYRPAEEIEIWNSVEHPISKLKRYMVHKGWFDETVENEYVKDIRKKVLKQIAVSEKKLKPNWREMFEGVYAEMPDHLIEQRSELEKH---IEAHKEHYPL 434
BLAST of 2-oxoisovalerate dehydrogenase subunit alpha vs. Ensembl Fly
Match: Pdha (gene:FBgn0028325 transcript:FBtr0070710) HSP 1 Score: 105.531 bits (262), Expect = 5.795e-24 Identity = 84/286 (29.37%), Postives = 130/286 (45.45%), Query Frame = 2
Query: 362 SFYMTHYGEEGVQIGSAAALNDGDLIFGQYREAGVGLWRGFTLEEMLNQCYGNKYDSNKGKQMPIH-YANKKLNYFSISSVLGTQMPHAVGAAYAFKRAQNGKCVICYFGDGASSVGDAHAALNFSATLDCPVIMLCRNNLYAISTPVHEQXXXXXXXXXXXXXXXATIRVDGNDLIAVYNATKAARELCVNENRPVLIEAMTYRIGSHSTSDDSLAYRSVDEVTWWDKHDNPILRFKFYLKQKNWWSDKEEEAWRNESRKLVVQAIEKAEKTNLPNPLILFEDVY 1216
F + G+E +G AA+ D D I YR G G + +L + G + +GK +H YA N++ + ++G Q+P G A K NG + +GDGA++ G A N + PVI +C NN Y + T + G + I VDG D++AV +AT+ A VN + P+++E TYR HS SD +YR+ +E+ + +PI FK + + E +A + RK V +A A+ L+ DVY
Sbjct: 22 GFCHLYSGQEACAVGMKAAMRDVDNIISAYRVHGWTYLMGVSPSGVLAELTGVQGGCARGKGGSMHMYAP---NFYGGNGIVGAQVPLGAGVGLACKYKGNGGMCLALYGDGAANQGQVFEAYNMAYLWKLPVIFVCENNNYGMGTS--SERASCNTDYYTRGDALPGIWVDGMDVLAVRSATEFAINY-VNTHGPLVMETNTYRYSGHSMSDPGTSYRTREEIQEVRQKRDPITSFKELCIELGLITTDEVKAIDLKVRKEVDEATAFAKSDAELGVSHLWTDVY 301
BLAST of 2-oxoisovalerate dehydrogenase subunit alpha vs. Ensembl Fly
Match: Pdha (gene:FBgn0028325 transcript:FBtr0070708) HSP 1 Score: 105.145 bits (261), Expect = 2.086e-23 Identity = 84/286 (29.37%), Postives = 130/286 (45.45%), Query Frame = 2
Query: 362 SFYMTHYGEEGVQIGSAAALNDGDLIFGQYREAGVGLWRGFTLEEMLNQCYGNKYDSNKGKQMPIH-YANKKLNYFSISSVLGTQMPHAVGAAYAFKRAQNGKCVICYFGDGASSVGDAHAALNFSATLDCPVIMLCRNNLYAISTPVHEQXXXXXXXXXXXXXXXATIRVDGNDLIAVYNATKAARELCVNENRPVLIEAMTYRIGSHSTSDDSLAYRSVDEVTWWDKHDNPILRFKFYLKQKNWWSDKEEEAWRNESRKLVVQAIEKAEKTNLPNPLILFEDVY 1216
F + G+E +G AA+ D D I YR G G + +L + G + +GK +H YA N++ + ++G Q+P G A K NG + +GDGA++ G A N + PVI +C NN Y + T + G + I VDG D++AV +AT+ A VN + P+++E TYR HS SD +YR+ +E+ + +PI FK + + E +A + RK V +A A+ L+ DVY
Sbjct: 93 GFCHLYSGQEACAVGMKAAMRDVDNIISAYRVHGWTYLMGVSPSGVLAELTGVQGGCARGKGGSMHMYAP---NFYGGNGIVGAQVPLGAGVGLACKYKGNGGMCLALYGDGAANQGQVFEAYNMAYLWKLPVIFVCENNNYGMGTS--SERASCNTDYYTRGDALPGIWVDGMDVLAVRSATEFAINY-VNTHGPLVMETNTYRYSGHSMSDPGTSYRTREEIQEVRQKRDPITSFKELCIELGLITTDEVKAIDLKVRKEVDEATAFAKSDAELGVSHLWTDVY 372
BLAST of 2-oxoisovalerate dehydrogenase subunit alpha vs. Ensembl Fly
Match: Pdha (gene:FBgn0028325 transcript:FBtr0070709) HSP 1 Score: 105.145 bits (261), Expect = 2.086e-23 Identity = 84/286 (29.37%), Postives = 130/286 (45.45%), Query Frame = 2
Query: 362 SFYMTHYGEEGVQIGSAAALNDGDLIFGQYREAGVGLWRGFTLEEMLNQCYGNKYDSNKGKQMPIH-YANKKLNYFSISSVLGTQMPHAVGAAYAFKRAQNGKCVICYFGDGASSVGDAHAALNFSATLDCPVIMLCRNNLYAISTPVHEQXXXXXXXXXXXXXXXATIRVDGNDLIAVYNATKAARELCVNENRPVLIEAMTYRIGSHSTSDDSLAYRSVDEVTWWDKHDNPILRFKFYLKQKNWWSDKEEEAWRNESRKLVVQAIEKAEKTNLPNPLILFEDVY 1216
F + G+E +G AA+ D D I YR G G + +L + G + +GK +H YA N++ + ++G Q+P G A K NG + +GDGA++ G A N + PVI +C NN Y + T + G + I VDG D++AV +AT+ A VN + P+++E TYR HS SD +YR+ +E+ + +PI FK + + E +A + RK V +A A+ L+ DVY
Sbjct: 93 GFCHLYSGQEACAVGMKAAMRDVDNIISAYRVHGWTYLMGVSPSGVLAELTGVQGGCARGKGGSMHMYAP---NFYGGNGIVGAQVPLGAGVGLACKYKGNGGMCLALYGDGAANQGQVFEAYNMAYLWKLPVIFVCENNNYGMGTS--SERASCNTDYYTRGDALPGIWVDGMDVLAVRSATEFAINY-VNTHGPLVMETNTYRYSGHSMSDPGTSYRTREEIQEVRQKRDPITSFKELCIELGLITTDEVKAIDLKVRKEVDEATAFAKSDAELGVSHLWTDVY 372
BLAST of 2-oxoisovalerate dehydrogenase subunit alpha vs. Ensembl Fly
Match: Pdha (gene:FBgn0028325 transcript:FBtr0070711) HSP 1 Score: 105.531 bits (262), Expect = 2.992e-23 Identity = 84/286 (29.37%), Postives = 130/286 (45.45%), Query Frame = 2
Query: 362 SFYMTHYGEEGVQIGSAAALNDGDLIFGQYREAGVGLWRGFTLEEMLNQCYGNKYDSNKGKQMPIH-YANKKLNYFSISSVLGTQMPHAVGAAYAFKRAQNGKCVICYFGDGASSVGDAHAALNFSATLDCPVIMLCRNNLYAISTPVHEQXXXXXXXXXXXXXXXATIRVDGNDLIAVYNATKAARELCVNENRPVLIEAMTYRIGSHSTSDDSLAYRSVDEVTWWDKHDNPILRFKFYLKQKNWWSDKEEEAWRNESRKLVVQAIEKAEKTNLPNPLILFEDVY 1216
F + G+E +G AA+ D D I YR G G + +L + G + +GK +H YA N++ + ++G Q+P G A K NG + +GDGA++ G A N + PVI +C NN Y + T + G + I VDG D++AV +AT+ A VN + P+++E TYR HS SD +YR+ +E+ + +PI FK + + E +A + RK V +A A+ L+ DVY
Sbjct: 137 GFCHLYSGQEACAVGMKAAMRDVDNIISAYRVHGWTYLMGVSPSGVLAELTGVQGGCARGKGGSMHMYAP---NFYGGNGIVGAQVPLGAGVGLACKYKGNGGMCLALYGDGAANQGQVFEAYNMAYLWKLPVIFVCENNNYGMGTS--SERASCNTDYYTRGDALPGIWVDGMDVLAVRSATEFAINY-VNTHGPLVMETNTYRYSGHSMSDPGTSYRTREEIQEVRQKRDPITSFKELCIELGLITTDEVKAIDLKVRKEVDEATAFAKSDAELGVSHLWTDVY 416
BLAST of 2-oxoisovalerate dehydrogenase subunit alpha vs. Ensembl Zebrafish
Match: bckdha (branched chain keto acid dehydrogenase E1 subunit alpha [Source:ZFIN;Acc:ZDB-GENE-050522-376]) HSP 1 Score: 469.544 bits (1207), Expect = 3.908e-152 Identity = 237/395 (60.00%), Postives = 293/395 (74.18%), Query Frame = 2
Query: 119 SADKPNFPQSRSEYTSQLNFIYPTDIKGIPLYRVLDGNGNLREDGLDPXXXXXXXXXXXXTMTLLNTMDRILYDSQRQGRISFYMTHYGEEGVQIGSAAALNDGDLIFGQYREAGVGLWRGFTLEEMLNQCYGNKYDSNKGKQMPIHYANKKLNYFSISSVLGTQMPHAVGAAYAFKRAQNGKCVICYFGDGASSVGDAHAALNFSATLDCPVIMLCRNNLYAISTPVHEQXXXXXXXXXXXXXXXATIRVDGNDLIAVYNATKAARELCVNENRPVLIEAMTYRIGSHSTSDDSLAYRSVDEVTWWDKHDNPILRFKFYLKQKNWWSDKEEEAWRNESRKLVVQAIEKAEKTNLPNPLILFEDVYDEMPTRIRSQMNKHYTFLKRNKEHYPISY 1303
S +KP FP + +E+ L FI P I GIP+YRV+D G + DP+ SKE + + MTLLNTMDRILY+SQRQGRISFYMT+YGEEG IGSAAAL+ DL+FGQYREAGV ++RGF L+ + QCY N D KG+QMP+HY +K LN+ +ISS L TQ+P A GAAYA KR + VICYFG+GA+S GDAHA NFSATL+CP+I CRNN YAISTP +EQYRGDGI +RG GYG+ +IRVDGND+ AVYNATK AR V EN+P LIEAMTYRIG HSTSDDS AYRSVDEV +WDK D+PI R + Y+ ++WW + EE AWR +SRKLV++A E+AE+ PNP ++F DVYDEM I Q + + +++ KEHYP+ +
Sbjct: 49 SDEKPQFPGASAEFIDHLEFIQPNVISGIPVYRVMDRQGQIINPSEDPQLSKETVLNFYQKMTLLNTMDRILYESQRQGRISFYMTNYGEEGTHIGSAAALDPSDLVFGQYREAGVLMYRGFPLDLFMAQCYANADDLGKGRQMPVHYGSKDLNFVTISSPLATQIPQAAGAAYAVKRENANRVVICYFGEGAASEGDAHAGFNFSATLECPLIFFCRNNGYAISTPTNEQYRGDGIAARGPGYGLMSIRVDGNDVFAVYNATKEARRRAVAENQPFLIEAMTYRIGHHSTSDDSSAYRSVDEVNYWDKQDHPISRLRHYMTARDWWGEDEERAWRKQSRKLVMEAFERAERRLKPNPDLMFTDVYDEMVPHIAKQKDSMWRHVQQYKEHYPLDH 443
BLAST of 2-oxoisovalerate dehydrogenase subunit alpha vs. Ensembl Zebrafish
Match: bckdha (branched chain keto acid dehydrogenase E1 subunit alpha [Source:ZFIN;Acc:ZDB-GENE-050522-376]) HSP 1 Score: 469.544 bits (1207), Expect = 3.908e-152 Identity = 237/395 (60.00%), Postives = 293/395 (74.18%), Query Frame = 2
Query: 119 SADKPNFPQSRSEYTSQLNFIYPTDIKGIPLYRVLDGNGNLREDGLDPXXXXXXXXXXXXTMTLLNTMDRILYDSQRQGRISFYMTHYGEEGVQIGSAAALNDGDLIFGQYREAGVGLWRGFTLEEMLNQCYGNKYDSNKGKQMPIHYANKKLNYFSISSVLGTQMPHAVGAAYAFKRAQNGKCVICYFGDGASSVGDAHAALNFSATLDCPVIMLCRNNLYAISTPVHEQXXXXXXXXXXXXXXXATIRVDGNDLIAVYNATKAARELCVNENRPVLIEAMTYRIGSHSTSDDSLAYRSVDEVTWWDKHDNPILRFKFYLKQKNWWSDKEEEAWRNESRKLVVQAIEKAEKTNLPNPLILFEDVYDEMPTRIRSQMNKHYTFLKRNKEHYPISY 1303
S +KP FP + +E+ L FI P I GIP+YRV+D G + DP+ SKE + + MTLLNTMDRILY+SQRQGRISFYMT+YGEEG IGSAAAL+ DL+FGQYREAGV ++RGF L+ + QCY N D KG+QMP+HY +K LN+ +ISS L TQ+P A GAAYA KR + VICYFG+GA+S GDAHA NFSATL+CP+I CRNN YAISTP +EQYRGDGI +RG GYG+ +IRVDGND+ AVYNATK AR V EN+P LIEAMTYRIG HSTSDDS AYRSVDEV +WDK D+PI R + Y+ ++WW + EE AWR +SRKLV++A E+AE+ PNP ++F DVYDEM I Q + + +++ KEHYP+ +
Sbjct: 49 SDEKPQFPGASAEFIDHLEFIQPNVISGIPVYRVMDRQGQIINPSEDPQLSKETVLNFYQKMTLLNTMDRILYESQRQGRISFYMTNYGEEGTHIGSAAALDPSDLVFGQYREAGVLMYRGFPLDLFMAQCYANADDLGKGRQMPVHYGSKDLNFVTISSPLATQIPQAAGAAYAVKRENANRVVICYFGEGAASEGDAHAGFNFSATLECPLIFFCRNNGYAISTPTNEQYRGDGIAARGPGYGLMSIRVDGNDVFAVYNATKEARRRAVAENQPFLIEAMTYRIGHHSTSDDSSAYRSVDEVNYWDKQDHPISRLRHYMTARDWWGEDEERAWRKQSRKLVMEAFERAERRLKPNPDLMFTDVYDEMVPHIAKQKDSMWRHVQQYKEHYPLDH 443
BLAST of 2-oxoisovalerate dehydrogenase subunit alpha vs. Ensembl Zebrafish
Match: pdha1a (pyruvate dehydrogenase E1 alpha 1 subunit a [Source:ZFIN;Acc:ZDB-GENE-040426-2719]) HSP 1 Score: 127.872 bits (320), Expect = 8.004e-31 Identity = 104/374 (27.81%), Postives = 166/374 (44.39%), Query Frame = 2
Query: 152 SEYTSQLNFIYPTDIKGIPLYRVLDGNGN----LREDGLDPXXXXXXXXXXXXTMTLLNTMDRILYDSQRQGRISFYMTHY-GEEGVQIGSAAALNDGDLIFGQYREAGVGLWRGFTLEEMLNQCYGNKYDSNKGKQMPIHYANKKLNYFSISSVLGTQMPHAVGAAYAFKRAQNGKCVICYFGDGASSVGDAHAALNFSATLDCPVIMLCRNNLYAISTPVHEQXXXXXXXXXXXXXXXATIRVDGNDLIAVYNATKAARELCVNENRPVLIEAMTYRIGSHSTSDDSLAYRSVDEVTWWDKHDNPILRFKFYLKQKNWWSDKEEEAWRNESRKLVVQAIEKAEKTNLPNPLILFEDV-----YDEMPTRIRS 1243
+++T Q F DIK ++++ +G RE+GL +TM + M+ +Q I + Y G+E +G A +N D + YR G L RG T+ E++ + G + KGK +H K +++ + ++G Q+P G A A K + +C +GDGA++ G N ++ P I +C NN Y + T V + G I +RVDG D++ V ATK A E C + P+L+E TYR HS SD ++YR+ +E+ +PI K + N S +E + E RK IE A + +P ED+ Y++ P +R
Sbjct: 38 ADFTPQATF----DIKKCDVHKLEEGPAVQAVLTREEGLQ----------YYRTMQTMRRMELKADQLYKQKIIRGFCHLYDGQEACAVGIEAGINLSDHLITAYRAHGYTLTRGGTVREIMAELTGRRGGIAKGKGGSMHMYTK--HFYGGNGIVGAQVPLGAGVALACKYQGKNELCVCLYGDGAANQGQIFETYNMASLWKLPCIFICENNKYGMGTSV--ERAAASTDYYKRGDFIPGLRVDGMDVLCVREATKFAAEHCRSGKGPILMELQTYRYHGHSMSDPGVSYRTREEIQEVRSKSDPISLLKDRMLSNNMASVEELKEIDVEVRK----EIEDAAQFATTDPEPPLEDLCNHIFYNDPPLEVRG 389
BLAST of 2-oxoisovalerate dehydrogenase subunit alpha vs. Ensembl Zebrafish
Match: pdha1a (pyruvate dehydrogenase E1 alpha 1 subunit a [Source:ZFIN;Acc:ZDB-GENE-040426-2719]) HSP 1 Score: 127.487 bits (319), Expect = 8.594e-31 Identity = 104/374 (27.81%), Postives = 166/374 (44.39%), Query Frame = 2
Query: 152 SEYTSQLNFIYPTDIKGIPLYRVLDGNGN----LREDGLDPXXXXXXXXXXXXTMTLLNTMDRILYDSQRQGRISFYMTHY-GEEGVQIGSAAALNDGDLIFGQYREAGVGLWRGFTLEEMLNQCYGNKYDSNKGKQMPIHYANKKLNYFSISSVLGTQMPHAVGAAYAFKRAQNGKCVICYFGDGASSVGDAHAALNFSATLDCPVIMLCRNNLYAISTPVHEQXXXXXXXXXXXXXXXATIRVDGNDLIAVYNATKAARELCVNENRPVLIEAMTYRIGSHSTSDDSLAYRSVDEVTWWDKHDNPILRFKFYLKQKNWWSDKEEEAWRNESRKLVVQAIEKAEKTNLPNPLILFEDV-----YDEMPTRIRS 1243
+++T Q F DIK ++++ +G RE+GL +TM + M+ +Q I + Y G+E +G A +N D + YR G L RG T+ E++ + G + KGK +H K +++ + ++G Q+P G A A K + +C +GDGA++ G N ++ P I +C NN Y + T V + G I +RVDG D++ V ATK A E C + P+L+E TYR HS SD ++YR+ +E+ +PI K + N S +E + E RK IE A + +P ED+ Y++ P +R
Sbjct: 31 ADFTPQATF----DIKKCDVHKLEEGPAVQAVLTREEGLQ----------YYRTMQTMRRMELKADQLYKQKIIRGFCHLYDGQEACAVGIEAGINLSDHLITAYRAHGYTLTRGGTVREIMAELTGRRGGIAKGKGGSMHMYTK--HFYGGNGIVGAQVPLGAGVALACKYQGKNELCVCLYGDGAANQGQIFETYNMASLWKLPCIFICENNKYGMGTSV--ERAAASTDYYKRGDFIPGLRVDGMDVLCVREATKFAAEHCRSGKGPILMELQTYRYHGHSMSDPGVSYRTREEIQEVRSKSDPISLLKDRMLSNNMASVEELKEIDVEVRK----EIEDAAQFATTDPEPPLEDLCNHIFYNDPPLEVRG 382
BLAST of 2-oxoisovalerate dehydrogenase subunit alpha vs. Ensembl Zebrafish
Match: pdha1a (pyruvate dehydrogenase E1 alpha 1 subunit a [Source:ZFIN;Acc:ZDB-GENE-040426-2719]) HSP 1 Score: 127.487 bits (319), Expect = 8.594e-31 Identity = 104/374 (27.81%), Postives = 166/374 (44.39%), Query Frame = 2
Query: 152 SEYTSQLNFIYPTDIKGIPLYRVLDGNGN----LREDGLDPXXXXXXXXXXXXTMTLLNTMDRILYDSQRQGRISFYMTHY-GEEGVQIGSAAALNDGDLIFGQYREAGVGLWRGFTLEEMLNQCYGNKYDSNKGKQMPIHYANKKLNYFSISSVLGTQMPHAVGAAYAFKRAQNGKCVICYFGDGASSVGDAHAALNFSATLDCPVIMLCRNNLYAISTPVHEQXXXXXXXXXXXXXXXATIRVDGNDLIAVYNATKAARELCVNENRPVLIEAMTYRIGSHSTSDDSLAYRSVDEVTWWDKHDNPILRFKFYLKQKNWWSDKEEEAWRNESRKLVVQAIEKAEKTNLPNPLILFEDV-----YDEMPTRIRS 1243
+++T Q F DIK ++++ +G RE+GL +TM + M+ +Q I + Y G+E +G A +N D + YR G L RG T+ E++ + G + KGK +H K +++ + ++G Q+P G A A K + +C +GDGA++ G N ++ P I +C NN Y + T V + G I +RVDG D++ V ATK A E C + P+L+E TYR HS SD ++YR+ +E+ +PI K + N S +E + E RK IE A + +P ED+ Y++ P +R
Sbjct: 31 ADFTPQATF----DIKKCDVHKLEEGPAVQAVLTREEGLQ----------YYRTMQTMRRMELKADQLYKQKIIRGFCHLYDGQEACAVGIEAGINLSDHLITAYRAHGYTLTRGGTVREIMAELTGRRGGIAKGKGGSMHMYTK--HFYGGNGIVGAQVPLGAGVALACKYQGKNELCVCLYGDGAANQGQIFETYNMASLWKLPCIFICENNKYGMGTSV--ERAAASTDYYKRGDFIPGLRVDGMDVLCVREATKFAAEHCRSGKGPILMELQTYRYHGHSMSDPGVSYRTREEIQEVRSKSDPISLLKDRMLSNNMASVEELKEIDVEVRK----EIEDAAQFATTDPEPPLEDLCNHIFYNDPPLEVRG 382
BLAST of 2-oxoisovalerate dehydrogenase subunit alpha vs. Ensembl Xenopus
Match: h6pd (hexose-6-phosphate dehydrogenase (glucose 1-dehydrogenase) [Source:Xenbase;Acc:XB-GENE-988586]) HSP 1 Score: 473.011 bits (1216), Expect = 1.158e-153 Identity = 245/411 (59.61%), Postives = 299/411 (72.75%), Query Frame = 2
Query: 86 KFNVLVSLYCTSADKPNFPQSRSEYTSQLNFIYPTDIKGIPLYRVLDGNGNLREDGLDPXXXXXXXXXXXXTMTLLNTMDRILYDSQRQGRISFYMTHYGEEGVQIGSAAALNDGDLIFGQYREAGVGLWRGFTLEEMLNQCYGNKYDSNKGKQMPIHYANKKLNYFSISSVLGTQMPHAVGAAYAFKRAQNGKCVICYFGDGASSVGDAHAALNFSATLDCPVIMLCRNNLYAISTPVHEQXXXXXXXXXXXXXXXATIRVDGNDLIAVYNATKAARELCVNENRPVLIEAMTYRIGSHSTSDDSLAYRSVDEVTWWDKHDNPILRFKFYLKQKNWWSDKEEEAWRNESRKLVVQAIEKAEKTNLPNPLILFEDVYDEMPTRIRSQMNKHYTFLKRNKEHYPISYDSPEK 1318
K + S + + +KP FP + +++ L FI P I GIP+YRV+D G + DPK KE +K TMTLLNTMDRILY+SQRQGRISFYMT+YGEEG +GSAAALND DL+FGQYREAGV ++RG+ L+ + QCYGN D KGKQMP+HY K LN+ +ISS L TQ+P AVGAAY+FKR + VICYFG+GA+S GDAHAA NFSATL+CPV+ CRNN YAISTP EQYRGDGI +RG GYGI +IRVDGND+ AVYNATK AR V EN+P LIEAMTYRIG HSTSDDS AYRSVDEV +WDK D+PI R + Y+ K WW +++E+ WR +SRK+V++A E+AE+ + P +F DVY EMP ++R Q LK EHYP+ DS EK
Sbjct: 12 KLYITGSEFTSLEEKPQFPGASADFVDSLEFIQPNVISGIPIYRVMDRQGQIINPSEDPKIPKEKVLKFYHTMTLLNTMDRILYESQRQGRISFYMTNYGEEGTHVGSAAALNDTDLVFGQYREAGVLMYRGYPLDLFMAQCYGNASDPGKGKQMPVHYGCKDLNFVTISSPLATQIPQAVGAAYSFKRENADRAVICYFGEGAASEGDAHAAFNFSATLECPVLFFCRNNGYAISTPTSEQYRGDGIAARGPGYGIMSIRVDGNDVFAVYNATKEARRRAVAENQPFLIEAMTYRIGHHSTSDDSSAYRSVDEVNYWDKQDHPISRLRHYMLHKGWWDEEQEKIWRKKSRKMVMEAFEEAERKHKPKVEHMFSDVYSEMPAQLRKQEESLMKHLKLYGEHYPL--DSYEK 420
BLAST of 2-oxoisovalerate dehydrogenase subunit alpha vs. Ensembl Xenopus
Match: h6pd (hexose-6-phosphate dehydrogenase (glucose 1-dehydrogenase) [Source:Xenbase;Acc:XB-GENE-988586]) HSP 1 Score: 471.855 bits (1213), Expect = 2.136e-153 Identity = 244/405 (60.25%), Postives = 297/405 (73.33%), Query Frame = 2
Query: 104 SLYCTSADKPNFPQSRSEYTSQLNFIYPTDIKGIPLYRVLDGNGNLREDGLDPXXXXXXXXXXXXTMTLLNTMDRILYDSQRQGRISFYMTHYGEEGVQIGSAAALNDGDLIFGQYREAGVGLWRGFTLEEMLNQCYGNKYDSNKGKQMPIHYANKKLNYFSISSVLGTQMPHAVGAAYAFKRAQNGKCVICYFGDGASSVGDAHAALNFSATLDCPVIMLCRNNLYAISTPVHEQXXXXXXXXXXXXXXXATIRVDGNDLIAVYNATKAARELCVNENRPVLIEAMTYRIGSHSTSDDSLAYRSVDEVTWWDKHDNPILRFKFYLKQKNWWSDKEEEAWRNESRKLVVQAIEKAEKTNLPNPLILFEDVYDEMPTRIRSQMNKHYTFLKRNKEHYPISYDSPEK 1318
S + + +KP FP + +++ L FI P I GIP+YRV+D G + DPK KE +K TMTLLNTMDRILY+SQRQGRISFYMT+YGEEG +GSAAALND DL+FGQYREAGV ++RG+ L+ + QCYGN D KGKQMP+HY K LN+ +ISS L TQ+P AVGAAY+FKR + VICYFG+GA+S GDAHAA NFSATL+CPV+ CRNN YAISTP EQYRGDGI +RG GYGI +IRVDGND+ AVYNATK AR V EN+P LIEAMTYRIG HSTSDDS AYRSVDEV +WDK D+PI R + Y+ K WW +++E+ WR +SRK+V++A E+AE+ + P +F DVY EMP ++R Q LK EHYP+ DS EK
Sbjct: 10 SEFTSLEEKPQFPGASADFVDSLEFIQPNVISGIPIYRVMDRQGQIINPSEDPKIPKEKVLKFYHTMTLLNTMDRILYESQRQGRISFYMTNYGEEGTHVGSAAALNDTDLVFGQYREAGVLMYRGYPLDLFMAQCYGNASDPGKGKQMPVHYGCKDLNFVTISSPLATQIPQAVGAAYSFKRENADRAVICYFGEGAASEGDAHAAFNFSATLECPVLFFCRNNGYAISTPTSEQYRGDGIAARGPGYGIMSIRVDGNDVFAVYNATKEARRRAVAENQPFLIEAMTYRIGHHSTSDDSSAYRSVDEVNYWDKQDHPISRLRHYMLHKGWWDEEQEKIWRKKSRKMVMEAFEEAERKHKPKVEHMFSDVYSEMPAQLRKQEESLMKHLKLYGEHYPL--DSYEK 412
BLAST of 2-oxoisovalerate dehydrogenase subunit alpha vs. Ensembl Xenopus
Match: h6pd (hexose-6-phosphate dehydrogenase (glucose 1-dehydrogenase) [Source:Xenbase;Acc:XB-GENE-988586]) HSP 1 Score: 472.241 bits (1214), Expect = 2.289e-153 Identity = 247/417 (59.23%), Postives = 304/417 (72.90%), Query Frame = 2
Query: 77 CASKFNVLV---SLYCTSADKPNFPQSRSEYTSQLNFIYPTDIKGIPLYRVLDGNGNLREDGLDPXXXXXXXXXXXXTMTLLNTMDRILYDSQRQGRISFYMTHYGEEGVQIGSAAALNDGDLIFGQYREAGVGLWRGFTLEEMLNQCYGNKYDSNKGKQMPIHYANKKLNYFSISSVLGTQMPHAVGAAYAFKRAQNGKCVICYFGDGASSVGDAHAALNFSATLDCPVIMLCRNNLYAISTPVHEQXXXXXXXXXXXXXXXATIRVDGNDLIAVYNATKAARELCVNENRPVLIEAMTYRIGSHSTSDDSLAYRSVDEVTWWDKHDNPILRFKFYLKQKNWWSDKEEEAWRNESRKLVVQAIEKAEKTNLPNPLILFEDVYDEMPTRIRSQMNKHYTFLKRNKEHYPISYDSPEK 1318
CA+ F+ ++ S + + +KP FP + +++ L FI P I GIP+YRV+D G + DPK KE +K TMTLLNTMDRILY+SQRQGRISFYMT+YGEEG +GSAAALND DL+FGQYREAGV ++RG+ L+ + QCYGN D KGKQMP+HY K LN+ +ISS L TQ+P AVGAAY+FKR + VICYFG+GA+S GDAHAA NFSATL+CPV+ CRNN YAISTP EQYRGDGI +RG GYGI +IRVDGND+ AVYNATK AR V EN+P LIEAMTYRIG HSTSDDS AYRSVDEV +WDK D+PI R + Y+ K WW +++E+ WR +SRK+V++A E+AE+ + P +F DVY EMP ++R Q LK EHYP+ DS EK
Sbjct: 4 CAN-FHTIIRSQSEFTSLEEKPQFPGASADFVDSLEFIQPNVISGIPIYRVMDRQGQIINPSEDPKIPKEKVLKFYHTMTLLNTMDRILYESQRQGRISFYMTNYGEEGTHVGSAAALNDTDLVFGQYREAGVLMYRGYPLDLFMAQCYGNASDPGKGKQMPVHYGCKDLNFVTISSPLATQIPQAVGAAYSFKRENADRAVICYFGEGAASEGDAHAAFNFSATLECPVLFFCRNNGYAISTPTSEQYRGDGIAARGPGYGIMSIRVDGNDVFAVYNATKEARRRAVAENQPFLIEAMTYRIGHHSTSDDSSAYRSVDEVNYWDKQDHPISRLRHYMLHKGWWDEEQEKIWRKKSRKMVMEAFEEAERKHKPKVEHMFSDVYSEMPAQLRKQEESLMKHLKLYGEHYPL--DSYEK 417
BLAST of 2-oxoisovalerate dehydrogenase subunit alpha vs. Ensembl Xenopus
Match: h6pd (hexose-6-phosphate dehydrogenase (glucose 1-dehydrogenase) [Source:Xenbase;Acc:XB-GENE-988586]) HSP 1 Score: 472.626 bits (1215), Expect = 2.568e-153 Identity = 244/405 (60.25%), Postives = 297/405 (73.33%), Query Frame = 2
Query: 104 SLYCTSADKPNFPQSRSEYTSQLNFIYPTDIKGIPLYRVLDGNGNLREDGLDPXXXXXXXXXXXXTMTLLNTMDRILYDSQRQGRISFYMTHYGEEGVQIGSAAALNDGDLIFGQYREAGVGLWRGFTLEEMLNQCYGNKYDSNKGKQMPIHYANKKLNYFSISSVLGTQMPHAVGAAYAFKRAQNGKCVICYFGDGASSVGDAHAALNFSATLDCPVIMLCRNNLYAISTPVHEQXXXXXXXXXXXXXXXATIRVDGNDLIAVYNATKAARELCVNENRPVLIEAMTYRIGSHSTSDDSLAYRSVDEVTWWDKHDNPILRFKFYLKQKNWWSDKEEEAWRNESRKLVVQAIEKAEKTNLPNPLILFEDVYDEMPTRIRSQMNKHYTFLKRNKEHYPISYDSPEK 1318
S + + +KP FP + +++ L FI P I GIP+YRV+D G + DPK KE +K TMTLLNTMDRILY+SQRQGRISFYMT+YGEEG +GSAAALND DL+FGQYREAGV ++RG+ L+ + QCYGN D KGKQMP+HY K LN+ +ISS L TQ+P AVGAAY+FKR + VICYFG+GA+S GDAHAA NFSATL+CPV+ CRNN YAISTP EQYRGDGI +RG GYGI +IRVDGND+ AVYNATK AR V EN+P LIEAMTYRIG HSTSDDS AYRSVDEV +WDK D+PI R + Y+ K WW +++E+ WR +SRK+V++A E+AE+ + P +F DVY EMP ++R Q LK EHYP+ DS EK
Sbjct: 31 SEFTSLEEKPQFPGASADFVDSLEFIQPNVISGIPIYRVMDRQGQIINPSEDPKIPKEKVLKFYHTMTLLNTMDRILYESQRQGRISFYMTNYGEEGTHVGSAAALNDTDLVFGQYREAGVLMYRGYPLDLFMAQCYGNASDPGKGKQMPVHYGCKDLNFVTISSPLATQIPQAVGAAYSFKRENADRAVICYFGEGAASEGDAHAAFNFSATLECPVLFFCRNNGYAISTPTSEQYRGDGIAARGPGYGIMSIRVDGNDVFAVYNATKEARRRAVAENQPFLIEAMTYRIGHHSTSDDSSAYRSVDEVNYWDKQDHPISRLRHYMLHKGWWDEEQEKIWRKKSRKMVMEAFEEAERKHKPKVEHMFSDVYSEMPAQLRKQEESLMKHLKLYGEHYPL--DSYEK 433
BLAST of 2-oxoisovalerate dehydrogenase subunit alpha vs. Ensembl Xenopus
Match: h6pd (hexose-6-phosphate dehydrogenase (glucose 1-dehydrogenase) [Source:Xenbase;Acc:XB-GENE-988586]) HSP 1 Score: 471.47 bits (1212), Expect = 4.645e-153 Identity = 243/403 (60.30%), Postives = 296/403 (73.45%), Query Frame = 2
Query: 110 YCTSADKPNFPQSRSEYTSQLNFIYPTDIKGIPLYRVLDGNGNLREDGLDPXXXXXXXXXXXXTMTLLNTMDRILYDSQRQGRISFYMTHYGEEGVQIGSAAALNDGDLIFGQYREAGVGLWRGFTLEEMLNQCYGNKYDSNKGKQMPIHYANKKLNYFSISSVLGTQMPHAVGAAYAFKRAQNGKCVICYFGDGASSVGDAHAALNFSATLDCPVIMLCRNNLYAISTPVHEQXXXXXXXXXXXXXXXATIRVDGNDLIAVYNATKAARELCVNENRPVLIEAMTYRIGSHSTSDDSLAYRSVDEVTWWDKHDNPILRFKFYLKQKNWWSDKEEEAWRNESRKLVVQAIEKAEKTNLPNPLILFEDVYDEMPTRIRSQMNKHYTFLKRNKEHYPISYDSPEK 1318
+ + +KP FP + +++ L FI P I GIP+YRV+D G + DPK KE +K TMTLLNTMDRILY+SQRQGRISFYMT+YGEEG +GSAAALND DL+FGQYREAGV ++RG+ L+ + QCYGN D KGKQMP+HY K LN+ +ISS L TQ+P AVGAAY+FKR + VICYFG+GA+S GDAHAA NFSATL+CPV+ CRNN YAISTP EQYRGDGI +RG GYGI +IRVDGND+ AVYNATK AR V EN+P LIEAMTYRIG HSTSDDS AYRSVDEV +WDK D+PI R + Y+ K WW +++E+ WR +SRK+V++A E+AE+ + P +F DVY EMP ++R Q LK EHYP+ DS EK
Sbjct: 25 FTSLEEKPQFPGASADFVDSLEFIQPNVISGIPIYRVMDRQGQIINPSEDPKIPKEKVLKFYHTMTLLNTMDRILYESQRQGRISFYMTNYGEEGTHVGSAAALNDTDLVFGQYREAGVLMYRGYPLDLFMAQCYGNASDPGKGKQMPVHYGCKDLNFVTISSPLATQIPQAVGAAYSFKRENADRAVICYFGEGAASEGDAHAAFNFSATLECPVLFFCRNNGYAISTPTSEQYRGDGIAARGPGYGIMSIRVDGNDVFAVYNATKEARRRAVAENQPFLIEAMTYRIGHHSTSDDSSAYRSVDEVNYWDKQDHPISRLRHYMLHKGWWDEEQEKIWRKKSRKMVMEAFEEAERKHKPKVEHMFSDVYSEMPAQLRKQEESLMKHLKLYGEHYPL--DSYEK 425
BLAST of 2-oxoisovalerate dehydrogenase subunit alpha vs. Ensembl Mouse
Match: Bckdha (branched chain ketoacid dehydrogenase E1, alpha polypeptide [Source:MGI Symbol;Acc:MGI:107701]) HSP 1 Score: 450.284 bits (1157), Expect = 7.561e-145 Identity = 235/393 (59.80%), Postives = 291/393 (74.05%), Query Frame = 2
Query: 125 DKPNFPQSRSEYTSQLNFIYPTDIKGIPLYRVLDGNGNLREDGLDPXXXXXXXXXXXXTMTLLNTMDRILYDSQRQGRISFYMTHYGEEGVQIGSAAALNDGDLIFGQYREAGVGLWRGFTLEEMLNQCYGNKYDSNKGKQMPIHYANKKLNYFSISSVLGTQMPHAVGAAYAFKRAQNGKCVICYFGDGASSVGDAHAALNFSATLDCPVIMLCRNNLYAISTPVHEQXXXXXXXXXXXXXXXATIRVDGNDLIAVYNATKAARELCVNENRPVLIEAMTYRIGSHSTSDDSLAYRSVDEVTWWDKHDNPILRFKFYLKQKNWWSDKEEEAWRNESRKLVVQAIEKAEKTNLPNPLILFEDVYDEMPTRIRSQMNKHYTFLKRNKEHYPISY 1303
DKP FP + +E+ +L FI P I GIP+YRV+D G + DP +E +K ++MTLLNTMDRILY+SQRQGRISFYMT+YGEEG +GSAAAL DL+FGQYREAGV ++R + LE ++QCYGN D KG+QMP+HY K+ ++ +ISS L TQ+P AVGAAYA KRA + VICYFG+GA+S GDAHA NF+ATL+CP+I CRNN YAISTP EQYRGDGI +RG GYGI +IRVDGND+ AVYNATK AR V EN+P LIEAMTYRIG HSTSDDS AYRSVDEV +WDK D+PI R + YL + WW +++E+AWR +SRK V++A E+AE+ PNP +LF DVY EMP ++R Q L+ EHYP+ +
Sbjct: 51 DKPQFPGASAEFVDKLEFIQPNVISGIPIYRVMDRQGQIINPSEDPHLPQEEVLKFYRSMTLLNTMDRILYESQRQGRISFYMTNYGEEGTHVGSAAALERTDLVFGQYREAGVLMYRDYPLELFMSQCYGNVNDPGKGRQMPVHYGCKERHFVTISSPLATQIPQAVGAAYAAKRANANRIVICYFGEGAASEGDAHAGFNFAATLECPIIFFCRNNGYAISTPTSEQYRGDGIAARGPGYGIMSIRVDGNDVFAVYNATKEARRRAVAENQPFLIEAMTYRIGHHSTSDDSSAYRSVDEVNYWDKQDHPISRLRQYLLNQGWWDEEQEKAWRKQSRKKVMEAFEQAERKLKPNPSLLFSDVYQEMPAQLRRQQESLARHLQTYGEHYPLDH 443
BLAST of 2-oxoisovalerate dehydrogenase subunit alpha vs. Ensembl Mouse
Match: Pdha1 (pyruvate dehydrogenase E1 alpha 1 [Source:MGI Symbol;Acc:MGI:97532]) HSP 1 Score: 121.709 bits (304), Expect = 7.097e-29 Identity = 86/272 (31.62%), Postives = 127/272 (46.69%), Query Frame = 2
Query: 383 GEEGVQIGSAAALNDGDLIFGQYREAGVGLWRGFTLEEMLNQCYGNKYDSNKGKQMPIHYANKKLNYFSISSVLGTQMPHAVGAAYAFKRAQNGKCVICY--FGDGASSVGDAHAALNFSATLDCPVIMLCRNNLYAISTPVHEQXXXXXXXXXXXXXXXATIRVDGNDLIAVYNATKAARELCVNENRPVLIEAMTYRIGSHSTSDDSLAYRSVDEVTWWDKHDNPILRFKFYLKQKNWWSDKEEEAWRNESRKLVVQAIEKAEKTNLPNP 1192
G+E +G A +N D + YR G RG + +L + G + KGK +H K N++ + ++G Q+P G A A K NGK +C +GDGA++ G A N +A P I +C NN Y + T V + G I +RVDG D++ V ATK A C + P+L+E TYR HS SD ++YR+ +E+ +PI+ K + N S +E + E RK + A + A T P P
Sbjct: 96 GQEACCVGLEAGINPTDHLITAYRAHGFTFTRGLPVRAILAELTGRRGGCAKGKGGSMHMYAK--NFYGGNGIVGAQVPLGAGIALACK--YNGKDEVCLTLYGDGAANQGQIFEAYNMAALWKLPCIFICENNRYGMGTSV--ERAAASTDYYKRGDFIPGLRVDGMDILCVREATKFAAAYCRSGKGPILMELQTYRYHGHSMSDPGVSYRTREEIQEVRSKSDPIMLLKDRMVNSNLASVEELKEIDVEVRKEIEDAAQFA--TADPEP 359
BLAST of 2-oxoisovalerate dehydrogenase subunit alpha vs. Ensembl Mouse
Match: Pdha2 (pyruvate dehydrogenase E1 alpha 2 [Source:MGI Symbol;Acc:MGI:97533]) HSP 1 Score: 119.013 bits (297), Expect = 6.888e-28 Identity = 84/277 (30.32%), Postives = 136/277 (49.10%), Query Frame = 2
Query: 383 GEEGVQIGSAAALNDGDLIFGQYREAGVGLWRGFTLEEMLNQCYGNKYDSNKGKQMPIHYANKKLNYFSISSVLGTQMPHAVGAAYAFKRAQNGKCVICYFGDGASSVGDAHAALNFSATLDCPVIMLCRNNLYAISTPVHEQXXXXXXXXXXXXXXXATIRVDGNDLIAVYNATKAARELCVNENRPVLIEAMTYRIGSHSTSDDSLAYRSVDEVTWWDKHDNPILRFKFYLKQKNWWSDKEEEAWRNESRKLVVQAIEKAEKTNLPNPLILFEDV 1213
G+E +G A +N D + YR G RG +++ +L + G K KGK +H K N++ + ++G Q+P G A+A K +NG+ + +GDGA++ G A N SA P + +C NNLY + T + G+ I +RV+G D++ V ATK A + C + P+++E TYR HS SD ++YRS +EV +PI+ + + N + +E + + +K V A + A T P P + ED+
Sbjct: 97 GQEACCVGLEAGINPTDHVITSYRAHGFCYTRGLSVKSILAELTGRKGGCAKGKGGSMHMYGK--NFYGGNGIVGAQVPLGAGVAFACKYLKNGQVCLALYGDGAANQGQVFEAYNMSALWKLPCVFICENNLYGMGTS--NERSAASTDYHKKGFIIPGLRVNGMDILCVREATKFAADHCRSGKGPIVMELQTYRYHGHSMSDPGISYRSREEVHNVRSKSDPIMLLRERIISNNLSNIEELKEIDADVKKEVEDAAQFA--TTDPEPAV--EDI 365
BLAST of 2-oxoisovalerate dehydrogenase subunit alpha vs. Ensembl Mouse
Match: Bckdha (branched chain ketoacid dehydrogenase E1, alpha polypeptide [Source:MGI Symbol;Acc:MGI:107701]) HSP 1 Score: 97.0561 bits (240), Expect = 2.309e-23 Identity = 59/82 (71.95%), Postives = 66/82 (80.49%), Query Frame = 2
Query: 725 LNFSATLDCPVIMLCRNNLYAISTPVHEQXXXXXXXXXXXXXXXATIRVDGNDLIAVYNATKAARELCVNENRPVLIEAMTY 970
NF+ATL+CP+I CRNN YAISTP EQYRGDGI +RG GYGI +IRVDGND+ AVYNATK AR V EN+P LIEAMTY
Sbjct: 1 FNFAATLECPIIFFCRNNGYAISTPTSEQYRGDGIAARGPGYGIMSIRVDGNDVFAVYNATKEARRRAVAENQPFLIEAMTY 82
BLAST of 2-oxoisovalerate dehydrogenase subunit alpha vs. UniProt/SwissProt
Match: sp|P11178|ODBA_BOVIN (2-oxoisovalerate dehydrogenase subunit alpha, mitochondrial OS=Bos taurus OX=9913 GN=BCKDHA PE=1 SV=1) HSP 1 Score: 451.825 bits (1161), Expect = 1.951e-144 Identity = 235/393 (59.80%), Postives = 293/393 (74.55%), Query Frame = 2
Query: 125 DKPNFPQSRSEYTSQLNFIYPTDIKGIPLYRVLDGNGNLREDGLDPXXXXXXXXXXXXTMTLLNTMDRILYDSQRQGRISFYMTHYGEEGVQIGSAAALNDGDLIFGQYREAGVGLWRGFTLEEMLNQCYGNKYDSNKGKQMPIHYANKKLNYFSISSVLGTQMPHAVGAAYAFKRAQNGKCVICYFGDGASSVGDAHAALNFSATLDCPVIMLCRNNLYAISTPVHEQXXXXXXXXXXXXXXXATIRVDGNDLIAVYNATKAARELCVNENRPVLIEAMTYRIGSHSTSDDSLAYRSVDEVTWWDKHDNPILRFKFYLKQKNWWSDKEEEAWRNESRKLVVQAIEKAEKTNLPNPLILFEDVYDEMPTRIRSQMNKHYTFLKRNKEHYPISY 1303
DKP FP + +E+ +L FI P I GIP+YRV+D G + DP +E +K K+MTLLNTMDRILY+SQRQGRISFYMT+YGEEG +GSAAAL+D DL+FGQYREAGV ++R + LE + QCYGN D KG+QMP+HY ++ ++ +ISS L TQ+P AVGAAYA KRA + VICYFG+GA+S GDAHA NF+ATL+CP+I CRNN YAISTP EQYRGDGI +RG GYGI +IRVDGND+ AVYNATK AR V EN+P LIEAMTYRIG HSTSDDS AYRSVDEV +WDK D+PI R + +L+ + WW D++E+AWR +SRK V++A E+AE+ PNP ++F DVY EMP ++R Q L+ EHYP+ +
Sbjct: 60 DKPQFPGASAEFIDKLEFIQPNVISGIPIYRVMDRQGQIINPSEDPHLPQEKVLKFYKSMTLLNTMDRILYESQRQGRISFYMTNYGEEGTHVGSAAALDDTDLVFGQYREAGVLMYRDYPLELFMAQCYGNVSDLGKGRQMPVHYGCRERHFVTISSPLATQIPQAVGAAYAAKRANANRVVICYFGEGAASEGDAHAGFNFAATLECPIIFFCRNNGYAISTPTSEQYRGDGIAARGPGYGILSIRVDGNDVFAVYNATKEARRRAVAENQPFLIEAMTYRIGHHSTSDDSSAYRSVDEVNYWDKQDHPISRLRHHLQSRGWWDDEQEKAWRKQSRKKVMEAFEQAERKLKPNPSLIFSDVYQEMPAQLRKQQESLARHLQTYGEHYPLDH 452
BLAST of 2-oxoisovalerate dehydrogenase subunit alpha vs. UniProt/SwissProt
Match: sp|Q8HXY4|ODBA_MACFA (2-oxoisovalerate dehydrogenase subunit alpha, mitochondrial OS=Macaca fascicularis OX=9541 GN=BCKDHA PE=2 SV=1) HSP 1 Score: 451.055 bits (1159), Expect = 2.490e-144 Identity = 237/393 (60.31%), Postives = 293/393 (74.55%), Query Frame = 2
Query: 125 DKPNFPQSRSEYTSQLNFIYPTDIKGIPLYRVLDGNGNLREDGLDPXXXXXXXXXXXXTMTLLNTMDRILYDSQRQGRISFYMTHYGEEGVQIGSAAALNDGDLIFGQYREAGVGLWRGFTLEEMLNQCYGNKYDSNKGKQMPIHYANKKLNYFSISSVLGTQMPHAVGAAYAFKRAQNGKCVICYFGDGASSVGDAHAALNFSATLDCPVIMLCRNNLYAISTPVHEQXXXXXXXXXXXXXXXATIRVDGNDLIAVYNATKAARELCVNENRPVLIEAMTYRIGSHSTSDDSLAYRSVDEVTWWDKHDNPILRFKFYLKQKNWWSDKEEEAWRNESRKLVVQAIEKAEKTNLPNPLILFEDVYDEMPTRIRSQMNKHYTFLKRNKEHYPISY 1303
DKP FP + +E+ +L FI P I GIP+YRV+D G + DP KE +K+ K+MTLLNTMDRILY+SQRQGRISFYMT+YGEEG +GSAAAL++ DL+FGQYREAGV ++R + LE + QCYGN D KG+QMP+HY K+ ++ +ISS L TQ+P AVGAAYA KRA + VICYFG+GA+S GDAHA NF+ATL+CP+I CRNN YAISTP EQYRGDGI +RG GYGI +IRVDGND+ AVYNATK AR V EN+P LIEAMTYRIG HSTSDDS AYRSVDEV +WDK D+PI R + YL + WW +++E+AWR +SRK V++A E+AE+ PNP +LF DVY EMP ++R Q L+ EHYP+ +
Sbjct: 50 DKPQFPGASAEFIDKLEFIQPNVISGIPIYRVMDRQGQIINPSEDPHLPKEKVLKLYKSMTLLNTMDRILYESQRQGRISFYMTNYGEEGTHVGSAAALDNTDLVFGQYREAGVLMYRDYPLELFMAQCYGNISDLGKGRQMPVHYGCKERHFVTISSPLATQIPQAVGAAYAAKRANANRVVICYFGEGAASEGDAHAGFNFAATLECPIIFFCRNNGYAISTPTSEQYRGDGIAARGPGYGIMSIRVDGNDVFAVYNATKEARRRAVAENQPFLIEAMTYRIGHHSTSDDSSAYRSVDEVNYWDKQDHPISRLRHYLLSQGWWDEEQEKAWRKQSRKKVMKAFEQAERKPKPNPNLLFSDVYQEMPAQLRKQQESLARHLQTYGEHYPLEH 442
BLAST of 2-oxoisovalerate dehydrogenase subunit alpha vs. UniProt/SwissProt
Match: sp|A5A6H9|ODBA_PANTR (2-oxoisovalerate dehydrogenase subunit alpha, mitochondrial OS=Pan troglodytes OX=9598 GN=BCKDHA PE=2 SV=1) HSP 1 Score: 450.669 bits (1158), Expect = 3.405e-144 Identity = 236/393 (60.05%), Postives = 293/393 (74.55%), Query Frame = 2
Query: 125 DKPNFPQSRSEYTSQLNFIYPTDIKGIPLYRVLDGNGNLREDGLDPXXXXXXXXXXXXTMTLLNTMDRILYDSQRQGRISFYMTHYGEEGVQIGSAAALNDGDLIFGQYREAGVGLWRGFTLEEMLNQCYGNKYDSNKGKQMPIHYANKKLNYFSISSVLGTQMPHAVGAAYAFKRAQNGKCVICYFGDGASSVGDAHAALNFSATLDCPVIMLCRNNLYAISTPVHEQXXXXXXXXXXXXXXXATIRVDGNDLIAVYNATKAARELCVNENRPVLIEAMTYRIGSHSTSDDSLAYRSVDEVTWWDKHDNPILRFKFYLKQKNWWSDKEEEAWRNESRKLVVQAIEKAEKTNLPNPLILFEDVYDEMPTRIRSQMNKHYTFLKRNKEHYPISY 1303
DKP FP + +E+ +L FI P I GIP+YRV+D G + DP KE +K+ K+MTLLNTMDRILY+SQRQGRISFYMT+YGEEG +GSAAAL++ DL+FGQYREAGV ++R + LE + QCYGN D KG+QMP+HY K+ ++ +ISS L TQ+P AVGAAYA KRA + VICYFG+GA+S GDAHA NF+ATL+CP+I CRNN YAISTP EQYRGDGI +RG GYGI +IRVDGND+ AVYNATK AR V EN+P LIEAMTYRIG HSTSDDS AYRSVDEV +WDK D+P+ R + YL + WW +++E+AWR +SRK V++A E+AE+ PNP +LF DVY EMP ++R Q L+ EHYP+ +
Sbjct: 50 DKPQFPGASAEFIDKLEFIQPNVISGIPIYRVMDRQGQIINPSEDPHLPKEKVLKLYKSMTLLNTMDRILYESQRQGRISFYMTNYGEEGTHVGSAAALDNTDLVFGQYREAGVLMYRDYPLELFMAQCYGNISDLGKGRQMPVHYGCKERHFVTISSPLATQIPQAVGAAYAAKRANANRVVICYFGEGAASEGDAHAGFNFAATLECPIIFFCRNNGYAISTPTSEQYRGDGIAARGPGYGIMSIRVDGNDVFAVYNATKEARRRAVAENQPFLIEAMTYRIGHHSTSDDSSAYRSVDEVNYWDKQDHPVSRLRHYLLSQGWWDEEQEKAWRKQSRKKVMEAFEQAERKPKPNPNLLFSDVYQEMPAQLRKQQESLARHLQTYGEHYPLDH 442
BLAST of 2-oxoisovalerate dehydrogenase subunit alpha vs. UniProt/SwissProt
Match: sp|P12694|ODBA_HUMAN (2-oxoisovalerate dehydrogenase subunit alpha, mitochondrial OS=Homo sapiens OX=9606 GN=BCKDHA PE=1 SV=2) HSP 1 Score: 450.284 bits (1157), Expect = 5.275e-144 Identity = 236/393 (60.05%), Postives = 293/393 (74.55%), Query Frame = 2
Query: 125 DKPNFPQSRSEYTSQLNFIYPTDIKGIPLYRVLDGNGNLREDGLDPXXXXXXXXXXXXTMTLLNTMDRILYDSQRQGRISFYMTHYGEEGVQIGSAAALNDGDLIFGQYREAGVGLWRGFTLEEMLNQCYGNKYDSNKGKQMPIHYANKKLNYFSISSVLGTQMPHAVGAAYAFKRAQNGKCVICYFGDGASSVGDAHAALNFSATLDCPVIMLCRNNLYAISTPVHEQXXXXXXXXXXXXXXXATIRVDGNDLIAVYNATKAARELCVNENRPVLIEAMTYRIGSHSTSDDSLAYRSVDEVTWWDKHDNPILRFKFYLKQKNWWSDKEEEAWRNESRKLVVQAIEKAEKTNLPNPLILFEDVYDEMPTRIRSQMNKHYTFLKRNKEHYPISY 1303
DKP FP + +E+ +L FI P I GIP+YRV+D G + DP KE +K+ K+MTLLNTMDRILY+SQRQGRISFYMT+YGEEG +GSAAAL++ DL+FGQYREAGV ++R + LE + QCYGN D KG+QMP+HY K+ ++ +ISS L TQ+P AVGAAYA KRA + VICYFG+GA+S GDAHA NF+ATL+CP+I CRNN YAISTP EQYRGDGI +RG GYGI +IRVDGND+ AVYNATK AR V EN+P LIEAMTYRIG HSTSDDS AYRSVDEV +WDK D+PI R + YL + WW +++E+AWR +SR+ V++A E+AE+ PNP +LF DVY EMP ++R Q L+ EHYP+ +
Sbjct: 50 DKPQFPGASAEFIDKLEFIQPNVISGIPIYRVMDRQGQIINPSEDPHLPKEKVLKLYKSMTLLNTMDRILYESQRQGRISFYMTNYGEEGTHVGSAAALDNTDLVFGQYREAGVLMYRDYPLELFMAQCYGNISDLGKGRQMPVHYGCKERHFVTISSPLATQIPQAVGAAYAAKRANANRVVICYFGEGAASEGDAHAGFNFAATLECPIIFFCRNNGYAISTPTSEQYRGDGIAARGPGYGIMSIRVDGNDVFAVYNATKEARRRAVAENQPFLIEAMTYRIGHHSTSDDSSAYRSVDEVNYWDKQDHPISRLRHYLLSQGWWDEEQEKAWRKQSRRKVMEAFEQAERKPKPNPNLLFSDVYQEMPAQLRKQQESLARHLQTYGEHYPLDH 442
BLAST of 2-oxoisovalerate dehydrogenase subunit alpha vs. UniProt/SwissProt
Match: sp|P11960|ODBA_RAT (2-oxoisovalerate dehydrogenase subunit alpha, mitochondrial (Fragment) OS=Rattus norvegicus OX=10116 GN=Bckdha PE=1 SV=1) HSP 1 Score: 449.514 bits (1155), Expect = 9.954e-144 Identity = 235/393 (59.80%), Postives = 291/393 (74.05%), Query Frame = 2
Query: 125 DKPNFPQSRSEYTSQLNFIYPTDIKGIPLYRVLDGNGNLREDGLDPXXXXXXXXXXXXTMTLLNTMDRILYDSQRQGRISFYMTHYGEEGVQIGSAAALNDGDLIFGQYREAGVGLWRGFTLEEMLNQCYGNKYDSNKGKQMPIHYANKKLNYFSISSVLGTQMPHAVGAAYAFKRAQNGKCVICYFGDGASSVGDAHAALNFSATLDCPVIMLCRNNLYAISTPVHEQXXXXXXXXXXXXXXXATIRVDGNDLIAVYNATKAARELCVNENRPVLIEAMTYRIGSHSTSDDSLAYRSVDEVTWWDKHDNPILRFKFYLKQKNWWSDKEEEAWRNESRKLVVQAIEKAEKTNLPNPLILFEDVYDEMPTRIRSQMNKHYTFLKRNKEHYPISY 1303
DKP FP + +E+ +L FI P I GIP+YRV+D G + DP +E +K+ ++MTLLNTMDRILY+SQRQGRISFYMT+YGEEG +GSAAAL DL+FGQYREAGV ++R + LE + QCYGN D KG+QMP+HY K+ ++ +ISS L TQ+P AVGAAYA KRA + VICYFG+GA+S GDAHA NF+ATL+CP+I CRNN YAISTP EQYRGDGI +RG GYGI +IRVDGND+ AVYNATK AR V EN+P LIEAMTYRIG HSTSDDS AYRSVDEV +WDK D+PI R + YL + WW +++E+AWR +SRK V++A E+AE+ PNP +LF DVY EMP ++R Q L+ EHYP+ +
Sbjct: 46 DKPQFPGASAEFVDKLEFIQPNVISGIPIYRVMDRQGQIINPSEDPHLPQEEVLKLYRSMTLLNTMDRILYESQRQGRISFYMTNYGEEGTHVGSAAALERTDLVFGQYREAGVLMYRDYPLELFMAQCYGNVSDPGKGRQMPVHYGCKERHFVTISSPLATQIPQAVGAAYAAKRANANQIVICYFGEGAASEGDAHAGFNFAATLECPIIFFCRNNGYAISTPTSEQYRGDGIAARGPGYGIMSIRVDGNDVFAVYNATKEARRRAVAENQPFLIEAMTYRIGHHSTSDDSSAYRSVDEVNYWDKQDHPISRLRQYLLNQGWWDEEQEKAWRKQSRKKVMEAFEQAERKLKPNPSLLFSDVYQEMPAQLRRQQESLARHLQTYGEHYPLDH 438
BLAST of 2-oxoisovalerate dehydrogenase subunit alpha vs. TrEMBL
Match: A0A2C9JEY2 (2-oxoisovalerate dehydrogenase subunit alpha OS=Biomphalaria glabrata OX=6526 GN=106055402 PE=3 SV=1) HSP 1 Score: 503.056 bits (1294), Expect = 1.784e-161 Identity = 250/405 (61.73%), Postives = 311/405 (76.79%), Query Frame = 2
Query: 104 SLYCTSAD--KPNFPQSRSEYTSQLNFIYPTDIKGIPLYRVLDGNGNLREDGLDPXXXXXXXXXXXXTMTLLNTMDRILYDSQRQGRISFYMTHYGEEGVQIGSAAALNDGDLIFGQYREAGVGLWRGFTLEEMLNQCYGNKYDSNKGKQMPIHYANKKLNYFSISSVLGTQMPHAVGAAYAFKRAQNGKCVICYFGDGASSVGDAHAALNFSATLDCPVIMLCRNNLYAISTPVHEQXXXXXXXXXXXXXXXATIRVDGNDLIAVYNATKAARELCVNENRPVLIEAMTYRIGSHSTSDDSLAYRSVDEVTWWDKHDNPILRFKFYLKQKNWWSDKEEEAWRNESRKLVVQAIEKAEKTNLPNPLILFEDVYDEMPTRIRSQMNKHYTFLKRNKEHYPISYDSP 1312
S Y TSA+ KPNFP SRSE+ S+L FI P + +GIP+YR L+ +GN + DPK + +K+ K MTLLNTMDR+LYDSQRQGRISFYMT+YGEEG IGSAAAL+ DLI+GQYREAGV +WRGF L++ ++QCYGN D KG+QMP+HY +++LN+ +ISS L TQMP A G+AYAFKR QNG CVICYFG+GA+S GDAHAA NF+A L+CP+I CRNN YAISTP +QYRGDGI SR GYG+ ++RVDGND+ AVYNATK ARE+C++++RPVLIEAMTYRIG HSTSDDS AYRSVDEV+ WDK DNPI RF+ Y+ + W D +E+ W+ +SRK+V++A AE P LFEDVYDEMP ++ QMN +K+ KEHYP+ + P
Sbjct: 35 SYYSTSAEIGKPNFPGSRSEFISKLEFIDPDNAEGIPVYRALNADGNFIDASQDPKLDESTVLKMYKDMTLLNTMDRVLYDSQRQGRISFYMTNYGEEGTHIGSAAALDPKDLIYGQYREAGVLMWRGFPLQQFMHQCYGNAKDIGKGRQMPVHYGSRELNFVTISSTLATQMPQASGSAYAFKRKQNGLCVICYFGEGAASEGDAHAAFNFAAVLNCPIIFFCRNNGYAISTPTKDQYRGDGIASRAAGYGMLSVRVDGNDVFAVYNATKKAREMCISQSRPVLIEAMTYRIGHHSTSDDSSAYRSVDEVSHWDKTDNPISRFRRYMMNQGLWDDDKEQQWKLDSRKMVMKAFAAAESEKRGRPESLFEDVYDEMPDHLKQQMNSMKNHVKQYKEHYPLEHYQP 439
BLAST of 2-oxoisovalerate dehydrogenase subunit alpha vs. TrEMBL
Match: T1IQP4 (2-oxoisovalerate dehydrogenase subunit alpha OS=Strigamia maritima OX=126957 PE=3 SV=1) HSP 1 Score: 499.204 bits (1284), Expect = 6.212e-160 Identity = 247/415 (59.52%), Postives = 318/415 (76.63%), Query Frame = 2
Query: 53 RVFRFTTYCASKFNVLVSLYCTSADKPNFPQSRSEYTSQLNFIYPTDIKGIPLYRVLDGNGNLREDGLDPXXXXXXXXXXXXTMTLLNTMDRILYDSQRQGRISFYMTHYGEEGVQIGSAAALNDGDLIFGQYREAGVGLWRGFTLEEMLNQCYGNKYDSNKGKQMPIHYANKKLNYFSISSVLGTQMPHAVGAAYAFKRAQNGKCVICYFGDGASSVGDAHAALNFSATLDCPVIMLCRNNLYAISTPVHEQXXXXXXXXXXXXXXXATIRVDGNDLIAVYNATKAARELCVNENRPVLIEAMTYRIGSHSTSDDSLAYRSVDEVTWWDKHDNPILRFKFYLKQKNWWSDKEEEAWRNESRKLVVQAIEKAEKTNLPNPLILFEDVYDEMPTRIRSQMNKHYTFLKRNKEHYPI 1297
R+ +F+ + + L S T D+PNFP S+S++T +L+FI GIP+YRV+D GN+ + DPK K+ +KI + MTLLNTMDRILY+SQRQGRISFYMT+YGEEG +GSAAALND DL+FGQYREAGV +WRGF+L++ +NQCY N D KG+QMP+HY + + ++ +ISS L TQMP AVGAAY+FKRAQNG CVICYFG+GA+S GDAHAA NF+ATLDCP+I CRNN YAISTP HEQYRGDGI RG YG+A+IRVDGND++AVYN TKAAR + E RPVLIEAMTYRIG HSTSDDS AYRSVDEV +WD+ D+PI R + ++K++N W D +E+AW++ES+K V+++ KAEK P P +LF DVYDE+ ++ QM++ + ++ +HYP+
Sbjct: 21 RIKKFSNTFSHVGSRLFSSSSTPDDQPNFPGSKSQFTDKLDFIRSDLYDGIPVYRVMDRKGNIINESEDPKLDKDLLVKIYQKMTLLNTMDRILYESQRQGRISFYMTNYGEEGTHMGSAAALNDKDLVFGQYREAGVLMWRGFSLDQFMNQCYSNCKDLGKGRQMPVHYGSPEHHFVTISSTLATQMPQAVGAAYSFKRAQNGLCVICYFGEGAASEGDAHAAFNFAATLDCPIIFFCRNNGYAISTPTHEQYRGDGIAGRGPAYGLASIRVDGNDVLAVYNVTKAARRIVTEEGRPVLIEAMTYRIGHHSTSDDSTAYRSVDEVRYWDEKDHPISRLRRFMKKQNLWDDDKEKAWKDESKKQVMKSFAKAEKLKKPAPELLFTDVYDELTPHLQEQMDEMKRHVSKHADHYPL 435
BLAST of 2-oxoisovalerate dehydrogenase subunit alpha vs. TrEMBL
Match: A0A1D1VN44 (2-oxoisovalerate dehydrogenase subunit alpha OS=Ramazzottius varieornatus OX=947166 GN=RvY_13520-1 PE=3 SV=1) HSP 1 Score: 497.664 bits (1280), Expect = 5.818e-159 Identity = 244/391 (62.40%), Postives = 307/391 (78.52%), Query Frame = 2
Query: 125 DKPNFPQSRSEYTSQLNFIYPTDIKGIPLYRVLDGNGNLREDGLDPXXXXXXXXXXXXTMTLLNTMDRILYDSQRQGRISFYMTHYGEEGVQIGSAAALNDGDLIFGQYREAGVGLWRGFTLEEMLNQCYGNKYDSNKGKQMPIHYANKKLNYFSISSVLGTQMPHAVGAAYAFKRAQNGKCVICYFGDGASSVGDAHAALNFSATLDCPVIMLCRNNLYAISTPVHEQXXXXXXXXXXXXXXXATIRVDGNDLIAVYNATKAARELCVNENRPVLIEAMTYRIGSHSTSDDSLAYRSVDEVTWWDKHDNPILRFKFYLKQKNWWSDKEEEAWRNESRKLVVQAIEKAEKTNLPNPLILFEDVYDEMPTRIRSQMNKHYTFLKRNKEHYPI 1297
DKP FP SRSE+T +L F+ P GIP+YRV+D G +R+ +PK + +K+ + MTLLN MDRILY+SQRQGRISFYMTH+GEEG+ IGSAA L+D DL + QYREAGV +WRGFTL++ +NQCYGN+ D KGKQMP+HY +K+L + ++SS L TQMP AVG+AYA+KRAQNG+ VICYFGDGA+S GDAHAA NFSATLDCP+I CRNN YAISTP +Q+RGDGI SRG GYGI TIRVDGND +A+YN TKAAR++ + +NRPVLIEAMTYRIG HSTSDDS AYRSVDEV WDK DNPI RF+ Y+ QK +W+D++E W+++++K V+QA ++AE P+P LF DVYDE+P ++ Q + F++ N EHYP+
Sbjct: 79 DKPRFPGSRSEWTEKLEFLMPEAYPGIPVYRVMDRKGLIRDAAQEPKLDEPTLVKMYQKMTLLNYMDRILYESQRQGRISFYMTHFGEEGILIGSAAGLDDKDLAYVQYREAGVLMWRGFTLDQFMNQCYGNEEDLGKGKQMPVHYGSKELAFVTVSSPLATQMPQAVGSAYAYKRAQNGQIVICYFGDGAASEGDAHAAFNFSATLDCPIIFFCRNNGYAISTPTSQQFRGDGIASRGPGYGIPTIRVDGNDTLAIYNVTKAARDISLQQNRPVLIEAMTYRIGHHSTSDDSSAYRSVDEVKHWDKEDNPIARFRRYITQKGYWNDEKETQWKDQAKKQVMQAFQRAEHKKKPSPEELFNDVYDELPWHLQKQRKEMMDFVRSNPEHYPL 469
BLAST of 2-oxoisovalerate dehydrogenase subunit alpha vs. TrEMBL
Match: V4AHL2 (2-oxoisovalerate dehydrogenase subunit alpha OS=Lottia gigantea OX=225164 GN=LOTGIDRAFT_202459 PE=3 SV=1) HSP 1 Score: 495.352 bits (1274), Expect = 1.329e-158 Identity = 245/393 (62.34%), Postives = 311/393 (79.13%), Query Frame = 2
Query: 125 DKPNFPQSRSEYTSQLNFIYPTDIKGIPLYRVLDGNGNLREDGLDPXXXXXXXXXXXXTMTLLNTMDRILYDSQRQGRISFYMTHYGEEGVQIGSAAALNDGDLIFGQYREAGVGLWRGFTLEEMLNQCYGNKYDSNKGKQMPIHYANKKLNYFSISSVLGTQMPHAVGAAYAFKRAQNGKCVICYFGDGASSVGDAHAALNFSATLDCPVIMLCRNNLYAISTPVHEQXXXXXXXXXXXXXXXATIRVDGNDLIAVYNATKAARELCVNENRPVLIEAMTYRIGSHSTSDDSLAYRSVDEVTWWDKHDNPILRFKFYLKQKNWWSDKEEEAWRNESRKLVVQAIEKAEKTNLPNPLILFEDVYDEMPTRIRSQMNKHYTFLKRNKEHYPISY 1303
++P FP S+SE+ S+L FI P + GIP+YR L +G + ED DPK E IK+ K MTLLNTMDRILY+SQRQGRISFYMT+YGEEG IGSAAAL+ D++FGQYREAGV +WRGFTL++ ++QCYGN+ D KG+QMP+HY +K++N+ +ISS L TQMP A GAAYA+KRA+NG CVICYFG+GA+S GDAHAA NF+A LDCPVI CRNN YAISTPV +QYRGDGI SRGIGYG+ T+RVDGND+ AVYNA K+AR++CV +NRPVLIEAMTYRIG HSTSDDS AYRSVDEV++WDK DNPI R + Y+ N+W +++E+AW+ ++RKLV+++ +AE PNP +F DVYD +P + Q N+ +K+ KE+YP+ +
Sbjct: 48 ERPEFPGSKSEFISKLKFIDPDKVDGIPVYRALGRDGKILEDSEDPKLDSETVIKMYKDMTLLNTMDRILYESQRQGRISFYMTNYGEEGTHIGSAAALDQKDMVFGQYREAGVLMWRGFTLDQFMDQCYGNENDIGKGRQMPVHYGSKEMNFMTISSPLATQMPQAAGAAYAYKRAKNGLCVICYFGEGAASEGDAHAAFNFAAVLDCPVIFFCRNNGYAISTPVKDQYRGDGIASRGIGYGMPTVRVDGNDVFAVYNAVKSARDMCVAQNRPVLIEAMTYRIGHHSTSDDSSAYRSVDEVSYWDKQDNPISRLRNYMTNNNFWDEEKEKAWKLKARKLVMKSFAEAENRKRPNPEEMFNDVYDILPKHLEEQKNEMKAHVKQYKENYPLEH 440
BLAST of 2-oxoisovalerate dehydrogenase subunit alpha vs. TrEMBL
Match: A0A443R1R3 (2-oxoisovalerate dehydrogenase subunit alpha OS=Dinothrombium tinctorium OX=1965070 GN=B4U79_06303 PE=3 SV=1) HSP 1 Score: 490.345 bits (1261), Expect = 1.365e-156 Identity = 249/406 (61.33%), Postives = 306/406 (75.37%), Query Frame = 2
Query: 80 ASKFNVLVSLYCTSADKPNFPQSRSEYTSQLNFIYPTDIKGIPLYRVLDGNGNLREDGLDPXXXXXXXXXXXXTMTLLNTMDRILYDSQRQGRISFYMTHYGEEGVQIGSAAALNDGDLIFGQYREAGVGLWRGFTLEEMLNQCYGNKYDSNKGKQMPIHYANKKLNYFSISSVLGTQMPHAVGAAYAFKRAQNGKCVICYFGDGASSVGDAHAALNFSATLDCPVIMLCRNNLYAISTPVHEQXXXXXXXXXXXXXXXATIRVDGNDLIAVYNATKAARELCVNENRPVLIEAMTYRIGSHSTSDDSLAYRSVDEVTWWDKHDNPILRFKFYLKQKNWWSDKEEEAWRNESRKLVVQAIEKAEKTNLPNPLILFEDVYDEMPTRIRSQMNKHYTFLKRNKEHYPI 1297
+SK + + T+ D+P FP SRSE+T +L F TD GIP+YRV++ +G++ ++ DP + KI K MTLLNTMDR+LY+SQRQGRISFYMT +GEEG GSAAALND DL+FGQYRE GV +WRGF L+++++QCYGN ++KG+QMP+HY +K L++ +ISS L TQMP AVGAAY FKR NGK VICYFG+GASS GDAHAALNF+ATLDCP+I CRNN YAISTP HEQYRGDGI RG GYGIA+IRVDGND +AVYN T AAR C+ E++PVLIEAMTYRIG HSTSDDS AYRSVDEV +W + D+PI R + Y++ K W D +E+ W+ ESR+ V+QA AEK PN + +F DVY+EMP +RSQ N LK KEHYPI
Sbjct: 34 SSKLSTSEAKVNTNNDRPQFPGSRSEWTQKLAFTRNTDYDGIPVYRVMNRDGSIIDESQDPNLGEAKITKIYKGMTLLNTMDRVLYESQRQGRISFYMTSFGEEGTHFGSAAALNDDDLVFGQYREGGVIMWRGFNLQQVMDQCYGNIDGNDKGRQMPVHYGDKNLHFVTISSTLATQMPQAVGAAYHFKRQANGKVVICYFGEGASSEGDAHAALNFAATLDCPIIFFCRNNGYAISTPTHEQYRGDGIAGRGSGYGIASIRVDGNDTLAVYNVTAAARNYCIEESKPVLIEAMTYRIGHHSTSDDSSAYRSVDEVRYWHQQDHPISRLRKYMELKGLWDDAKEKEWKEESRRQVLQAFVAAEKKPKPNVIEMFTDVYNEMPDNLRSQYNDLKAHLKVYKEHYPI 439
BLAST of 2-oxoisovalerate dehydrogenase subunit alpha vs. Ensembl Cavefish
Match: bckdha (branched chain keto acid dehydrogenase E1 subunit alpha [Source:NCBI gene;Acc:103041479]) HSP 1 Score: 464.922 bits (1195), Expect = 1.802e-150 Identity = 234/396 (59.09%), Postives = 292/396 (73.74%), Query Frame = 2
Query: 110 YCTSADKPNFPQSRSEYTSQLNFIYPTDIKGIPLYRVLDGNGNLREDGLDPXXXXXXXXXXXXTMTLLNTMDRILYDSQRQGRISFYMTHYGEEGVQIGSAAALNDGDLIFGQYREAGVGLWRGFTLEEMLNQCYGNKYDSNKGKQMPIHYANKKLNYFSISSVLGTQMPHAVGAAYAFKRAQNGKCVICYFGDGASSVGDAHAALNFSATLDCPVIMLCRNNLYAISTPVHEQXXXXXXXXXXXXXXXATIRVDGNDLIAVYNATKAARELCVNENRPVLIEAMTYRIGSHSTSDDSLAYRSVDEVTWWDKHDNPILRFKFYLKQKNWWSDKEEEAWRNESRKLVVQAIEKAEKTNLPNPLILFEDVYDEMPTRIRSQMNKHYTFLKRNKEHYPI 1297
+ +SA+KP FP + +E+ L FI P I GIP+YRV+D G + DP SKE + + MTLLNTMDRILY+SQRQGRISFYMT+YGEEG +GSAAAL+ DL+FGQYREAGV ++RGF L+ + QCY N D KG+QMP+HY K LN+ +ISS L TQ+P A GAAYA KR + VICYFG+GA+S GDAHA NFSATL+CP+I CRNN YAISTP +EQYRGDGI +RG GYG+ +IRVDGND+ AVYNATK AR V EN+P LIEAMTYRIG HSTSDDS AYRSVDEV +WDK D+PI R + Y+ ++WW + EE AWR +SRKLV++A E+AE+ P+P ++F DVYD+M + Q + +++ KEHYP+
Sbjct: 46 FDSSAEKPQFPGASAEFVDHLEFIQPNVISGIPIYRVMDRQGQIINPSEDPNLSKETVLNFYQKMTLLNTMDRILYESQRQGRISFYMTNYGEEGTHVGSAAALDPTDLVFGQYREAGVLMYRGFPLDLFMAQCYANADDLGKGRQMPVHYGCKDLNFVTISSPLATQIPQAAGAAYAVKRENANRAVICYFGEGAASEGDAHAGFNFSATLECPLIFFCRNNGYAISTPTNEQYRGDGIAARGPGYGMLSIRVDGNDVFAVYNATKEARRRAVAENQPFLIEAMTYRIGHHSTSDDSSAYRSVDEVNYWDKQDHPISRLRHYMTARDWWGEDEERAWRKQSRKLVMEAFERAERRLKPHPDLMFTDVYDQMTPGLEKQKEAMWRHVQQYKEHYPL 441
BLAST of 2-oxoisovalerate dehydrogenase subunit alpha vs. Ensembl Cavefish
Match: bckdha (branched chain keto acid dehydrogenase E1 subunit alpha [Source:NCBI gene;Acc:103041479]) HSP 1 Score: 421.394 bits (1082), Expect = 3.891e-135 Identity = 209/332 (62.95%), Postives = 256/332 (77.11%), Query Frame = 2
Query: 302 MTLLNTMDRILYDSQRQGRISFYMTHYGEEGVQIGSAAALNDGDLIFGQYREAGVGLWRGFTLEEMLNQCYGNKYDSNKGKQMPIHYANKKLNYFSISSVLGTQMPHAVGAAYAFKRAQNGKCVICYFGDGASSVGDAHAALNFSATLDCPVIMLCRNNLYAISTPVHEQXXXXXXXXXXXXXXXATIRVDGNDLIAVYNATKAARELCVNENRPVLIEAMTYRIGSHSTSDDSLAYRSVDEVTWWDKHDNPILRFKFYLKQKNWWSDKEEEAWRNESRKLVVQAIEKAEKTNLPNPLILFEDVYDEMPTRIRSQMNKHYTFLKRNKEHYPI 1297
MTLLNTMDRILY+SQRQGRISFYMT+YGEEG +GSAAAL+ DL+FGQYREAGV ++RGF L+ + QCY N D KG+QMP+HY K LN+ +ISS L TQ+P A GAAYA KR + VICYFG+GA+S GDAHA NFSATL+CP+I CRNN YAISTP +EQYRGDGI +RG GYG+ +IRVDGND+ AVYNATK AR V EN+P LIEAMTYRIG HSTSDDS AYRSVDEV +WDK D+PI R + Y+ ++WW + EE AWR +SRKLV++A E+AE+ P+P ++F DVYD+M + Q + +++ KEHYP+
Sbjct: 39 MTLLNTMDRILYESQRQGRISFYMTNYGEEGTHVGSAAALDPTDLVFGQYREAGVLMYRGFPLDLFMAQCYANADDLGKGRQMPVHYGCKDLNFVTISSPLATQIPQAAGAAYAVKRENANRAVICYFGEGAASEGDAHAGFNFSATLECPLIFFCRNNGYAISTPTNEQYRGDGIAARGPGYGMLSIRVDGNDVFAVYNATKEARRRAVAENQPFLIEAMTYRIGHHSTSDDSSAYRSVDEVNYWDKQDHPISRLRHYMTARDWWGEDEERAWRKQSRKLVMEAFERAERRLKPHPDLMFTDVYDQMTPGLEKQKEAMWRHVQQYKEHYPL 370
BLAST of 2-oxoisovalerate dehydrogenase subunit alpha vs. Ensembl Cavefish
Match: ENSAMXT00000025204.2 (pep primary_assembly:Astyanax_mexicanus-2.0:12:7364240:7371214:-1 gene:ENSAMXG00000024490.2 transcript:ENSAMXT00000025204.2 gene_biotype:protein_coding transcript_biotype:protein_coding) HSP 1 Score: 147.517 bits (371), Expect = 1.113e-39 Identity = 97/320 (30.31%), Postives = 168/320 (52.50%), Query Frame = 3
Query: 2796 RTKIISRGSILFQNKEFP--FELPKGCSITRAWFMR*LANEDEVNRS*LLFSLSDEAAYCF*CXXXXXXXXXXXXXXXXASGFSKR*KIE-KLIAHENSHSHRKSFTTWKEAEQRIIDGKTLDAYIRTQIQTEKQRW*NVLKRILACIKLLDSQNLALC*KN*SLTAEAGMNFGNFLSLLKLIAEYDPLLESYLKLASESPGSVSYLSPEIQNKFISLLASIVRNKLLKDIK*NEYY*ILLDSTPDLGHRGQLSKVIRFVDIDFENKTINIKESFLGFIEMHAKDAATFETVIVAKLQSDNIPLDDCRLQCYGNAAVMTG 3746
R +I+ +G + + EFP E P T+ + R + N +++ RS L++S+S ++ +CF C +L + GF K + L HE S H + W E ++R+ + T+D +T +Q E + W V++R++A I L +N AL + + + GNFL+ ++L+A++DP++ +++ V YLS IQN+ I+L+ NK+L++I Y +++D TPD+ H+ QLS V+R V+ D +++I E F GFI++ V++ LQ N+ + DCR Q Y N + M G
Sbjct: 30 RCQIVRKGPVQITDIEFPQNSENPPR-RFTKENYRRTMKNGEKILRSWLVYSMSTDSVFCFPCTVLGKRDNALSN-----CGFHKWKNLTYHLKEHEYSKGHCDNMRNWHELQRRLQNKTTIDQRQQTLMQIEIEHWKAVIRRVIAIICHLAERNQAL---RGTTSVLYDPHNGNFLAQVELMAKFDPVMNEHIRRRQNQEAKVHYLSGTIQNEIIALIG----NKVLEEIITQRDYSVIMDCTPDISHKEQLSVVLRLVNCD---PSVSIAEHFFGFIDVEDTSGKGLTEVLLDHLQKHNLSISDCRGQSYDNGSNMMG 333 HSP 2 Score: 38.1206 bits (87), Expect = 1.113e-39 Identity = 19/54 (35.19%), Postives = 30/54 (55.56%), Query Frame = 1
Query: 3760 QQRIRAR----NHRALFVNCDNHSLNLAGVHSTKQDPLVVTFFGTIESIYVFLS 3909
+Q +RAR N++AL + C +H LNL + K L +FFG ++ +Y S
Sbjct: 335 KQGVRARILQLNNKALCIPCSSHKLNLVVADAAKSSVLSTSFFGVLQRLYNLFS 388
BLAST of 2-oxoisovalerate dehydrogenase subunit alpha vs. Ensembl Cavefish
Match: ENSAMXT00000033195.1 (pep primary_assembly:Astyanax_mexicanus-2.0:16:11277158:11279506:-1 gene:ENSAMXG00000030798.1 transcript:ENSAMXT00000033195.1 gene_biotype:protein_coding transcript_biotype:protein_coding) HSP 1 Score: 137.887 bits (346), Expect = 6.737e-39 Identity = 81/235 (34.47%), Postives = 130/235 (55.32%), Query Frame = 3
Query: 3060 KLIAHENSHSHRKSFTTWKEAEQRIIDGKTLDAYIRTQIQTEKQRW*NVLKRILACIKLLDSQNLALC*KN*SLTAEAGMNFGNFLSLLKLIAEYDPLLESYL-KLASESPGS--VSYLSPEIQNKFISLLASIVRNKLLKDIK*NEYY*ILLDSTPDLGHRGQLSKVIRFVDIDFENKTI-NIKESFLGFIEMHAKDAATFETVIVAKLQSDNIPLDDCRLQCYGNAAVMTGHI 3752
K HE H++ + WK + ++ +D +++ Q+QTE ++ +L+R+L L S+NLA K +L ++ GNFL L+L+A YDP + +L K+ + GS YLSP+ QN+FI L V + +LK+ + YY ++ DSTPD+ H Q ++R+V D E++ + I E F+ F + H K +I+ LQS+ IPL +CR Q Y N A M+G +
Sbjct: 141 KFPEHEKHTPHKQCYVKWKSLQHSLLVATGVDGHLQKQLQTEAEKHTKILERLLDVTLHLASRNLAFRGKTSNLD---DVHNGNFLGTLELLAHYDPFIHEHLEKVKQKKKGSRLTHYLSPDTQNEFIELCGKRVLSTILKEREDAIYYSVICDSTPDISHTEQNVILVRYVHQDKEDRGVWKIVERFIEFKDFHKKTGQEISEMIIEALQSNGIPLQECRGQGYDNGANMSGKV 372 HSP 2 Score: 45.0542 bits (105), Expect = 6.737e-39 Identity = 25/70 (35.71%), Postives = 34/70 (48.57%), Query Frame = 1
Query: 3757 LQQRIRARNHRALFVNCDNHSLNLAGVHSTKQDPLVVTFFGTIESIYVFLSFNSSMGTTKK----CFTHR 3954
+Q +I N A F C H+LNL GVH+ + P V TFFG++ +Y S + K C HR
Sbjct: 375 VQAQILKANPLATFSPCATHTLNLVGVHAAESCPEVATFFGSVNRLYNLFSASPERWAILKEKTGCSLHR 444
BLAST of 2-oxoisovalerate dehydrogenase subunit alpha vs. Ensembl Cavefish
Match: ENSAMXT00000044961.1 (pep primary_assembly:Astyanax_mexicanus-2.0:APWO02000032.1:419978:423709:1 gene:ENSAMXG00000036481.1 transcript:ENSAMXT00000044961.1 gene_biotype:protein_coding transcript_biotype:protein_coding) HSP 1 Score: 143.665 bits (361), Expect = 9.957e-39 Identity = 93/322 (28.88%), Postives = 169/322 (52.48%), Query Frame = 3
Query: 2796 RTKIISRGSILFQNKEFP--FELPKGCSITRAWFMR*LANEDEVNRS*LLFSLSDEAAYCF*CXXXXXXXXXXXXXXXXASGFSKR*KIE-KLIAHENSHSHRKSFTTWKEAEQRIIDGKTLDAYIRTQIQTEKQRW*NVLKRILACIKLLDSQNLALC*KN*SLTAE-AGMNFGNFLSLLKLIAEYDPLLESYLKLASESPGSVSYLSPEIQNKFISLLASIVRNKLLKDIK*NEYY*ILLDSTPDLGHRGQLSKVIRFVDIDFENKTINIKESFLGFIEMHAKDAATFETVIVAKLQSDNIPLDDCRLQCYGNAAVMTGH 3749
R +I+ +G++ + +FP E P T+ + R + N +++ RS L++S+S ++ +CF C + + F K + L HE S H + W E ++R+ + T+D + +Q E + W V++R++A I L +N AL T+E + GNFL+ ++L+A++DP++ +++ V YLS IQN+ I+L+ + V ++++ + +YY +++D TPD+ H+ QLS V+R V+ D +++I E F GFI++ V++ LQ N+ + DCR Q Y N + M G
Sbjct: 80 RCQIVRKGTVQITDIQFPQNSENPPR-RFTKENYRRTMKNGEKILRSWLVYSMSTDSVFCFPCTVFGKRDNALSKLW-----FHKWKNLTYHLKEHEYSKGHCDNMRNWHELQRRLQNKTTIDQRQQALMQIEIEHWKAVIRRVIAIICHLAERNQALR----GTTSELYDPHNGNFLAQVELMAKFDPVMNEHIRRIQNQEAKVHYLSGTIQNEIIALIGNKVLEEIVRRAQRAKYYSVIMDCTPDISHKEQLSVVLRLVNCD---PSVSIAEHFFGFIDVEDTSGKGLTEVLLDHLQKHNLSISDCRGQSYDNGSNMMGQ 388 HSP 2 Score: 38.5058 bits (88), Expect = 9.957e-39 Identity = 18/51 (35.29%), Postives = 29/51 (56.86%), Query Frame = 1
Query: 3757 LQQRIRARNHRALFVNCDNHSLNLAGVHSTKQDPLVVTFFGTIESIYVFLS 3909
+Q RI N++AL + C +H+LNL + K L +FFG ++ +Y S
Sbjct: 392 VQARILQLNNKALCIPCSSHTLNLVVADAAKSSVLSTSFFGVLQRLYNLFS 442
BLAST of 2-oxoisovalerate dehydrogenase subunit alpha vs. Ensembl Sea Lamprey
Match: bckdha (branched chain keto acid dehydrogenase E1 subunit alpha [Source:ZFIN;Acc:ZDB-GENE-050522-376]) HSP 1 Score: 458.759 bits (1179), Expect = 1.817e-149 Identity = 242/396 (61.11%), Postives = 295/396 (74.49%), Query Frame = 2
Query: 125 DKPNFPQSRSEYTSQLNFIYPTDIKGIPLYRVLDGNGNLREDGLDPXXXXXXXXXXXXTMTLLNTMDRILYDSQRQGRISFYMTHYGEEGVQIGSAAALNDGDLIFGQYREAGVGLWRGFTLEEMLNQCYGNKYDSNKGKQMPIHYANKKLNYFSISSVLGTQMPH-----AVGAAYAFKRAQNGKCVICYFGDGASSVGDAHAALNFSATLDCPVIMLCRNNLYAISTPVHEQXXXXXXXXXXXXXXXATIRVDGNDLIAVYNATKAARELCVNENRPVLIEAMTYRIGSHSTSDDSLAYRSVDEVTWWDKHDNPILRFKFYLKQKNWWSDKEEEAWRNESRKLVVQAIEKAEKTNLPNPLILFEDVYDEMPTRIRSQMNKHYTFLKRNKEHYPI 1297
DKP FP + +EY+ + FI P I GIP+YRV+D G + DPK KE +K+ K MTLLNTMDRILY+SQRQGRISFYMT+YGEEG +GSAAAL DL+FGQYREAGV +WR F L+ ++QCYGN D KG+QMP+HY + +LN+ +ISS L TQ+P AVGAAYA+KRA N + VICYFG+GA+S GDAHA NFSATL+CPVI CRNN YAISTP EQYRGDGI +RG GYGI +IRVDGND+ AVYNAT+ AR V+EN+P LIEAMTYRIG HSTSDDS AYRSVDEV +WDK D+PI R + Y+ +++ W+D E+ WR +SRKLV++A EKAEK P+P LF DVY EM I+ QM++ +K EHYP+
Sbjct: 4 DKPLFPGASAEYSDTMEFIQPNVIAGIPVYRVMDRQGQIINPKEDPKLDKETVLKMYKKMTLLNTMDRILYESQRQGRISFYMTNYGEEGTHMGSAAALEPHDLVFGQYREAGVLMWRDFPLDMFMSQCYGNVDDPGKGRQMPVHYGSNELNFVTISSPLATQIPQARTHAAVGAAYAYKRANNDRVVICYFGEGAASEGDAHAGFNFSATLECPVIFFCRNNGYAISTPTDEQYRGDGIAARGPGYGILSIRVDGNDVFAVYNATREARRRAVSENQPTLIEAMTYRIGHHSTSDDSSAYRSVDEVNYWDKQDHPISRLRNYMLRESMWNDSLEKDWRKQSRKLVLEAFEKAEKRLKPSPSELFHDVYKEMTPHIQRQMDEMRRHVKIYAEHYPM 399
BLAST of 2-oxoisovalerate dehydrogenase subunit alpha vs. Ensembl Yeast
Match: PDA1 (E1 alpha subunit of the pyruvate dehydrogenase (PDH) complex; catalyzes the direct oxidative decarboxylation of pyruvate to acetyl-CoA; phosphorylated; regulated by glucose; PDH complex is concentrated in spots within the mitochondrial matrix, often near the ERMES complex and near peroxisomes [Source:SGD;Acc:S000000980]) HSP 1 Score: 137.502 bits (345), Expect = 6.136e-35 Identity = 87/289 (30.10%), Postives = 140/289 (48.44%), Query Frame = 2
Query: 383 GEEGVQIGSAAALNDGDLIFGQYREAGVGLWRGFTLEEMLNQCYGNKYDSNKGKQMPIH-YANKKLNYFSISSVLGTQMPHAVGAAYAFKRAQNGKCVICYFGDGASSVGDAHAALNFSATLDCPVIMLCRNNLYAISTPVHEQXXXXXXXXXXXXXXXATIRVDGNDLIAVYNATKAARELCVNENRPVLIEAMTYRIGSHSTSDDSLAYRSVDEVTWWDKHDNPILRFKFYLKQKNWWSDKEEEAWRNESRKLVVQAIEKAEKTNLPNPL--ILFEDVY---DEMPT 1231
G+E + +G A+ D I YR G RG +++ +L + G + + GK +H YA ++ + ++G Q+P G A+A + C +GDGAS+ G + N + + PV+ C NN Y + T RG ++V+G D++AVY A+K A++ C++ P+++E TYR G HS SD YR+ DE+ ++PI K +L ++ E +A+ +RK V + +E A+ P ILFEDVY E PT
Sbjct: 116 GQEAIAVGIENAITKLDSIITSYRCHGFTFMRGASVKAVLAELMGRRAGVSYGKGGSMHLYAP---GFYGGNGIVGAQVPLGAGLAFAHQYKNEDACSFTLYGDGASNQGQVFESFNMAKLWNLPVVFCCENNKYGMGTAASRSSAMTEYFKRGQYI--PGLKVNGMDILAVYQASKFAKDWCLSGKGPLVLEYETYRYGGHSMSDPGTTYRTRDEIQHMRSKNDPIAGLKMHLIDLGIATEAEVKAYDKSARKYVDEQVELADAAPPPEAKLSILFEDVYVKGTETPT 399
BLAST of 2-oxoisovalerate dehydrogenase subunit alpha vs. Ensembl Nematostella
Match: EDO43057 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7RZV6]) HSP 1 Score: 443.736 bits (1140), Expect = 7.277e-143 Identity = 227/392 (57.91%), Postives = 279/392 (71.17%), Query Frame = 2
Query: 125 DKPNFPQSRS-EYTSQLNFIYPTDIKGI-PLYRVLDGNGNLREDGLDPXXXXXXXXXXXXTMTLLNTMDRILYDSQRQGRISFYMTHYGEEGVQIGSAAALNDGDLIFGQYREAGVGLWRGFTLEEMLNQCYGNKYDSNKGKQMPIHYANKKLNYFSISSVLGTQMPHAVGAAYAFKRAQNGKCVICYFGDGASSVGDAHAALNFSATLDCPVIMLCRNNLYAISTPVHEQXXXXXXXXXXXXXXXATIRVDGNDLIAVYNATKAARELCVNENRPVLIEAMTYRIGSHSTSDDSLAYRSVDEVTWWDKHDNPILRFKFYLKQKNWWSDKEEEAWRNESRKLVVQAIEKAEKTNLPNPLILFEDVYDEMPTRIRSQMNKHYTFLKRNKEHYP 1294
DKP +P + + +T +L F+ P D +GI P+YRV+D G + D DPK + + + K MTLLNTMDRILY+SQRQGRISFYMT+YGEE GSAAAL DLI GQYREAGV +WRGFTL + +NQCY N++D+ KG+QMP+HY +K+LN+ +ISS L TQMP A GAAYA KR G CV+CYFGDGA+S GDAH+A NF+ATLD PVI CRNN YAISTP EQYRGDGI RG YG+ IRVDGND+ AVYN TK ARE+ VNENRPVL+EAMTYRIG HSTSDDS YRS+ EV +WDK D+PI R ++Y++ K WW +E+ W+ E+R V+QA AEK P LF DVY E ++ Q + + + YP
Sbjct: 46 DKPRYPGAMNCSFTEKLEFVDPMDPQGIIPVYRVMDRQGKIIIDSHDPKLPEGTIVDMYKKMTLLNTMDRILYESQRQGRISFYMTNYGEEATHFGSAAALEMEDLIMGQYREAGVLMWRGFTLADFMNQCYANQHDAGKGRQMPVHYGSKELNFVTISSTLATQMPQASGAAYALKRQGKGNCVMCYFGDGAASEGDAHSAFNFAATLDAPVIFFCRNNGYAISTPTREQYRGDGIACRGRSYGMLAIRVDGNDIFAVYNVTKKAREIAVNENRPVLVEAMTYRIGHHSTSDDSSVYRSLKEVNYWDKEDHPISRLRYYMEDKGWWDQDQEQQWKKEARLQVMQAFADAEKALKPPVKELFLDVYKEFTPHLQEQYKECVDHVAKYPHEYP 437
BLAST of 2-oxoisovalerate dehydrogenase subunit alpha vs. Ensembl Nematostella
Match: EDO33561 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7SRY1]) HSP 1 Score: 120.939 bits (302), Expect = 4.723e-29 Identity = 86/287 (29.97%), Postives = 133/287 (46.34%), Query Frame = 2
Query: 362 SFYMTHYGEEGVQIGSAAALNDGDLIFGQYREAGVGLWRGFTLEEMLNQCYGNKYDSNKGKQMPIHYANKKLNYFSISSVLGTQMPHAVGAAYAFKRAQNGKCVICYFGDGASSVGDAHAALNFSATLDCPVIMLCRNNLYAISTPVHEQXXXXXXXXXXXXXXXATIRVDGNDLIAVYNATKAARELCVNENRPVLIEAMTYRIGSHSTSDDSLAYRSVDEVTWWDKHDNPILRFKFYLKQKNWWSDKEEEAWRNESRKLVVQAIEKAEKTNLPNPLI--LFEDVY 1216
F + G+E +G A+++ D + YR G RG + E+L + G K +GK +H + Y+ + ++G Q+P G A A K NG+ + +GDGA++ G N + + P I +C NN Y + T V + G I IRVDG D++ V ATK A + + P+L+E TYR HS SD +YRS DE+ K +PI + L S + + E++ + +A+E A+ N P P + LF VY
Sbjct: 92 GFCHLYSGQEACCVGMEASIDKNDSVITAYRCHGWTYMRGRSAREVLCELTGRKTGCTQGKGGSMHMYGHE--YYGGNGIVGAQVPLGAGIALAHKLRGNGRICLTLYGDGAANQGQLFETYNMAKLWNLPCIFICENNGYGMGTSV--ERAAATTEYYSRGDYIPGIRVDGMDVLTVREATKWAVDYARSGKGPILMELKTYRYYGHSMSDPGTSYRSRDEIQSVRKTRDPITGLREKLLDSGLASTDDIKKIEQEAKAEIDEAVECAK--NDPEPPLDDLFMHVY 372
BLAST of 2-oxoisovalerate dehydrogenase subunit alpha vs. Ensembl Medaka
Match: bckdha (branched chain keto acid dehydrogenase E1 subunit alpha [Source:NCBI gene;Acc:101166649]) HSP 1 Score: 461.07 bits (1185), Expect = 6.809e-149 Identity = 232/394 (58.88%), Postives = 290/394 (73.60%), Query Frame = 2
Query: 116 TSADKPNFPQSRSEYTSQLNFIYPTDIKGIPLYRVLDGNGNLREDGLDPXXXXXXXXXXXXTMTLLNTMDRILYDSQRQGRISFYMTHYGEEGVQIGSAAALNDGDLIFGQYREAGVGLWRGFTLEEMLNQCYGNKYDSNKGKQMPIHYANKKLNYFSISSVLGTQMPHAVGAAYAFKRAQNGKCVICYFGDGASSVGDAHAALNFSATLDCPVIMLCRNNLYAISTPVHEQXXXXXXXXXXXXXXXATIRVDGNDLIAVYNATKAARELCVNENRPVLIEAMTYRIGSHSTSDDSLAYRSVDEVTWWDKHDNPILRFKFYLKQKNWWSDKEEEAWRNESRKLVVQAIEKAEKTNLPNPLILFEDVYDEMPTRIRSQMNKHYTFLKRNKEHYPI 1297
+S +KP FP + +++ L FI P I GIP+YRV+D GN+ DP+ SKE + + MT+LNTMDRILY+SQRQGRISFYMT+YGEEG IGSAAAL D++FGQYREAGV ++RGF L+ + QCY N D KG+QMP+HY K LN+ +ISS L TQ+P A GAAYA KR + VICYFG+GA+S GDAHA NFSATL+CP+I CRNN YAISTP +EQYRGDGI +RG GYG+ +IRVDGND+ AVYNATK AR V EN+P LIEAMTYRIG HSTSDDS AYRSVDEV +WDK D+PI R + Y+ + WWS+ +E +WR +SRK V++A E+AE+ PNP +LF DVY EM + Q + + +++ KEHYP+
Sbjct: 51 SSLEKPQFPGASADFVDHLEFIQPNVISGIPVYRVMDRQGNIINPSQDPQLSKETVLNFYQKMTMLNTMDRILYESQRQGRISFYMTNYGEEGTHIGSAAALEPTDMVFGQYREAGVLMYRGFPLDLFMAQCYANADDLGKGRQMPVHYGCKDLNFVTISSPLATQIPQAAGAAYALKRENLNRAVICYFGEGAASEGDAHAGFNFSATLECPLIFFCRNNGYAISTPTNEQYRGDGIAARGPGYGMLSIRVDGNDVFAVYNATKEARRRAVAENQPFLIEAMTYRIGHHSTSDDSSAYRSVDEVNYWDKQDHPISRLRHYMTARGWWSEDDERSWRKQSRKTVMEAFERAERRLKPNPELLFTDVYQEMTPGLSRQRDSMWRHVQQYKEHYPV 444
BLAST of 2-oxoisovalerate dehydrogenase subunit alpha vs. Ensembl Medaka
Match: ENSORLT00000028133.1 (zinc finger MYM-type protein 1-like [Source:NCBI gene;Acc:111948955]) HSP 1 Score: 141.354 bits (355), Expect = 9.649e-39 Identity = 111/390 (28.46%), Postives = 192/390 (49.23%), Query Frame = 3
Query: 2595 ENSVATDADDRAIEPIDYMNESQDLSDDEKNLVVVTQDVIPAVFLFHDLAYLEFDRETQLSIVSQLLRTKIISRG-SILFQNKEFPFELPKGCSITRAWFMR*LANEDEVNRS*LLFSLSDEAAYCF*CXXXXXX----XXXXXXXXXXASGFSKR*KIEKLIAHENSHSHRKSFTTWKEAEQRIIDGKTLDAYIRTQIQTEKQRW*NVLKRILACIKLLDSQNLALC*KN*SLTAEAGMNFGNFLSLLKLIAEYDPLLESYL-KLASESPGSVSYLSPEIQNKFISLLASIVRNKLLKDIK*NEYY*ILLDSTPDLGHRGQLSKVIRFVDIDFENKTINIKESFLGFIEMHAKDAATFETVIVAKLQSDNIPLDDCRLQCYGNAAVMTG 3746
E S ++A+D + E+ ++ DE L +D L D S ++ +R +++ RG S + + FP G S +F + L + +++ R+ L++S + +CF C L ++ + + +++K AS + L AHE S H WKE RI GKT+D ++ E+ RW VL R++A ++ L +NLAL +L + GNFL ++L+A +DP+++ +L ++ + SY+ +QN+ I LL+S + + ++ DIK +Y+ I+LD T D+ H QLS +IR V + + I+E F+GF+E ++I+ +L+ I +DCR Q Y N A M G
Sbjct: 82 EQSFDSEAED-VVPSTSTQLETSEMPGDETPLTPTAED-----------QPLPTDPAKWPSPLTDRIRMELVRRGPSSIPPDFVFPRNDSDGRSCHHHYFRKTLVSGEKIARTWLMYSKVKNSLFCFCCKLFSNKNINLTTSGTANWKHASTY--------LTAHEKSPEHLNCMKAWKELSGRIRSGKTIDKQEMALLEEERVRWRAVLTRLIAIVQSLAVRNLALRGHTETLFTSSN---GNFLKEVELMARFDPIMKDHLNRVLRGTASHNSYIGHHVQNELIDLLSSKILSAIVDDIKKAKYFSIILDCTLDISHTEQLSVIIRVVSL---MEKPQIREHFMGFLEAEESTGQHLASMILNRLEELGISFEDCRGQSYDNGANMKG 445 HSP 2 Score: 41.2022 bits (95), Expect = 9.649e-39 Identity = 17/51 (33.33%), Postives = 30/51 (58.82%), Query Frame = 1
Query: 3757 LQQRIRARNHRALFVNCDNHSLNLAGVHSTKQDPLVVTFFGTIESIYVFLS 3909
+Q R+ +N RALF+ C H+LNL + K+ +++FG ++ +Y S
Sbjct: 450 VQARLLEKNPRALFLPCGAHTLNLVVCDAAKRSVDAMSYFGVLQKLYTLFS 500
BLAST of 2-oxoisovalerate dehydrogenase subunit alpha vs. Ensembl Medaka
Match: ENSORLT00000042294.1 (zinc finger MYM-type protein 1-like [Source:NCBI gene;Acc:110016639]) HSP 1 Score: 141.354 bits (355), Expect = 9.649e-39 Identity = 111/390 (28.46%), Postives = 192/390 (49.23%), Query Frame = 3
Query: 2595 ENSVATDADDRAIEPIDYMNESQDLSDDEKNLVVVTQDVIPAVFLFHDLAYLEFDRETQLSIVSQLLRTKIISRG-SILFQNKEFPFELPKGCSITRAWFMR*LANEDEVNRS*LLFSLSDEAAYCF*CXXXXXX----XXXXXXXXXXASGFSKR*KIEKLIAHENSHSHRKSFTTWKEAEQRIIDGKTLDAYIRTQIQTEKQRW*NVLKRILACIKLLDSQNLALC*KN*SLTAEAGMNFGNFLSLLKLIAEYDPLLESYL-KLASESPGSVSYLSPEIQNKFISLLASIVRNKLLKDIK*NEYY*ILLDSTPDLGHRGQLSKVIRFVDIDFENKTINIKESFLGFIEMHAKDAATFETVIVAKLQSDNIPLDDCRLQCYGNAAVMTG 3746
E S ++A+D + E+ ++ DE L +D L D S ++ +R +++ RG S + + FP G S +F + L + +++ R+ L++S + +CF C L ++ + + +++K AS + L AHE S H WKE RI GKT+D ++ E+ RW VL R++A ++ L +NLAL +L + GNFL ++L+A +DP+++ +L ++ + SY+ +QN+ I LL+S + + ++ DIK +Y+ I+LD T D+ H QLS +IR V + + I+E F+GF+E ++I+ +L+ I +DCR Q Y N A M G
Sbjct: 82 EQSFDSEAED-VVPSTSTQLETSEMPGDETPLTPTAED-----------QPLPTDPAKWPSPLTDRIRMELVRRGPSSIPPDFVFPRNDSDGRSCHHHYFRKTLVSGEKIARTWLMYSKVKNSLFCFCCKLFSNKNINLTTSGTANWKHASTY--------LTAHEKSPEHLNCMKAWKELSGRIRSGKTIDKQEMALLEEERVRWRAVLTRLIAIVQSLAVRNLALRGHTETLFTSSN---GNFLKEVELMARFDPIMKDHLNRVLRGTASHNSYIGHHVQNELIDLLSSKILSAIVDDIKKAKYFSIILDCTLDISHTEQLSVIIRVVSL---MEKPQIREHFMGFLEAEESTGQHLASMILNRLEELGISFEDCRGQSYDNGANMKG 445 HSP 2 Score: 41.2022 bits (95), Expect = 9.649e-39 Identity = 17/51 (33.33%), Postives = 30/51 (58.82%), Query Frame = 1
Query: 3757 LQQRIRARNHRALFVNCDNHSLNLAGVHSTKQDPLVVTFFGTIESIYVFLS 3909
+Q R+ +N RALF+ C H+LNL + K+ +++FG ++ +Y S
Sbjct: 450 VQARLLEKNPRALFLPCGAHTLNLVVCDAAKRSVDAMSYFGVLQKLYTLFS 500
BLAST of 2-oxoisovalerate dehydrogenase subunit alpha vs. Ensembl Medaka
Match: ENSORLT00000045044.1 (zinc finger MYM-type protein 1-like [Source:NCBI gene;Acc:111948193]) HSP 1 Score: 141.354 bits (355), Expect = 9.649e-39 Identity = 111/390 (28.46%), Postives = 192/390 (49.23%), Query Frame = 3
Query: 2595 ENSVATDADDRAIEPIDYMNESQDLSDDEKNLVVVTQDVIPAVFLFHDLAYLEFDRETQLSIVSQLLRTKIISRG-SILFQNKEFPFELPKGCSITRAWFMR*LANEDEVNRS*LLFSLSDEAAYCF*CXXXXXX----XXXXXXXXXXASGFSKR*KIEKLIAHENSHSHRKSFTTWKEAEQRIIDGKTLDAYIRTQIQTEKQRW*NVLKRILACIKLLDSQNLALC*KN*SLTAEAGMNFGNFLSLLKLIAEYDPLLESYL-KLASESPGSVSYLSPEIQNKFISLLASIVRNKLLKDIK*NEYY*ILLDSTPDLGHRGQLSKVIRFVDIDFENKTINIKESFLGFIEMHAKDAATFETVIVAKLQSDNIPLDDCRLQCYGNAAVMTG 3746
E S ++A+D + E+ ++ DE L +D L D S ++ +R +++ RG S + + FP G S +F + L + +++ R+ L++S + +CF C L ++ + + +++K AS + L AHE S H WKE RI GKT+D ++ E+ RW VL R++A ++ L +NLAL +L + GNFL ++L+A +DP+++ +L ++ + SY+ +QN+ I LL+S + + ++ DIK +Y+ I+LD T D+ H QLS +IR V + + I+E F+GF+E ++I+ +L+ I +DCR Q Y N A M G
Sbjct: 82 EQSFDSEAED-VVPSTSTQLETSEMPGDETPLTPTAED-----------QPLPTDPAKWPSPLTDRIRMELVRRGPSSIPPDFVFPRNDSDGRSCHHHYFRKTLVSGEKIARTWLMYSKVKNSLFCFCCKLFSNKNINLTTSGTANWKHASTY--------LTAHEKSPEHLNCMKAWKELSGRIRSGKTIDKQEMALLEEERVRWRAVLTRLIAIVQSLAVRNLALRGHTETLFTSSN---GNFLKEVELMARFDPIMKDHLNRVLRGTASHNSYIGHHVQNELIDLLSSKILSAIVDDIKKAKYFSIILDCTLDISHTEQLSVIIRVVSL---MEKPQIREHFMGFLEAEESTGQHLASMILNRLEELGISFEDCRGQSYDNGANMKG 445 HSP 2 Score: 41.2022 bits (95), Expect = 9.649e-39 Identity = 17/51 (33.33%), Postives = 30/51 (58.82%), Query Frame = 1
Query: 3757 LQQRIRARNHRALFVNCDNHSLNLAGVHSTKQDPLVVTFFGTIESIYVFLS 3909
+Q R+ +N RALF+ C H+LNL + K+ +++FG ++ +Y S
Sbjct: 450 VQARLLEKNPRALFLPCGAHTLNLVVCDAAKRSVDAMSYFGVLQKLYTLFS 500
BLAST of 2-oxoisovalerate dehydrogenase subunit alpha vs. Ensembl Medaka
Match: pdha1a (pyruvate dehydrogenase E1 component subunit alpha, mitochondrial [Source:NCBI gene;Acc:101165911]) HSP 1 Score: 127.872 bits (320), Expect = 4.421e-31 Identity = 84/270 (31.11%), Postives = 130/270 (48.15%), Query Frame = 2
Query: 383 GEEGVQIGSAAALNDGDLIFGQYREAGVGLWRGFTLEEMLNQCYGNKYDSNKGKQMPIHYANKKLNYFSISSVLGTQMPHAVGAAYAFKRAQNGKCVICYFGDGASSVGDAHAALNFSATLDCPVIMLCRNNLYAISTPVHEQXXXXXXXXXXXXXXXATIRVDGNDLIAVYNATKAARELCVNENRPVLIEAMTYRIGSHSTSDDSLAYRSVDEVTWWDKHDNPILRFKFYLKQKNWWSDKEEEAWRNESRKLVVQAIEKAEKTNLPNP 1192
G+E +G A++N D + YR G RG T+++++ + G + KGK +H K N++ + ++G Q+P G A A K N + +C +GDGA++ G N ++ PVI +C NN Y + T V + G I +RVDG D++ V AT+ A E C + P+L+E TYR HS SD ++YR+ +E+ +PI K L N S +E + E RK + A + A T P P
Sbjct: 92 GQEACAVGIEASINMSDHLITAYRAHGYTYTRGGTVKKIMAELTGRRGGIAKGKGGSMHMYCK--NFYGGNGIVGAQVPLGAGVALACKYQGNNELCVCLYGDGAANQGQIFETYNMASLWKLPVIFICENNRYGMGTSV--ERAAASTDYYKRGEFIPGLRVDGMDVLCVREATRFAAEHCRSGKGPILMELQTYRYHGHSMSDPGISYRTREEIQEVRSKSDPISLLKDRLLSNNMASVEELKVIDVEVRKEIEDAAQFA--TTDPEP 355
BLAST of 2-oxoisovalerate dehydrogenase subunit alpha vs. Planmine SMEST
Match: SMESG000021409.1 (SMESG000021409.1) HSP 1 Score: 833.558 bits (2152), Expect = 0.000e+0 Identity = 427/427 (100.00%), Postives = 427/427 (100.00%), Query Frame = 2
Query: 41 MLLNRVFRFTTYCASKFNVLVSLYCTSADKPNFPQSRSEYTSQLNFIYPTDIKGIPLYRVLDGNGNLREDGLDPXXXXXXXXXXXXTMTLLNTMDRILYDSQRQGRISFYMTHYGEEGVQIGSAAALNDGDLIFGQYREAGVGLWRGFTLEEMLNQCYGNKYDSNKGKQMPIHYANKKLNYFSISSVLGTQMPHAVGAAYAFKRAQNGKCVICYFGDGASSVGDAHAALNFSATLDCPVIMLCRNNLYAISTPVHEQXXXXXXXXXXXXXXXATIRVDGNDLIAVYNATKAARELCVNENRPVLIEAMTYRIGSHSTSDDSLAYRSVDEVTWWDKHDNPILRFKFYLKQKNWWSDKEEEAWRNESRKLVVQAIEKAEKTNLPNPLILFEDVYDEMPTRIRSQMNKHYTFLKRNKEHYPISYDSPEKI 1321
MLLNRVFRFTTYCASKFNVLVSLYCTSADKPNFPQSRSEYTSQLNFIYPTDIKGIPLYRVLDGNGNLREDGLDPKFSKEFSIKIIKTMTLLNTMDRILYDSQRQGRISFYMTHYGEEGVQIGSAAALNDGDLIFGQYREAGVGLWRGFTLEEMLNQCYGNKYDSNKGKQMPIHYANKKLNYFSISSVLGTQMPHAVGAAYAFKRAQNGKCVICYFGDGASSVGDAHAALNFSATLDCPVIMLCRNNLYAISTPVHEQYRGDGIGSRGIGYGIATIRVDGNDLIAVYNATKAARELCVNENRPVLIEAMTYRIGSHSTSDDSLAYRSVDEVTWWDKHDNPILRFKFYLKQKNWWSDKEEEAWRNESRKLVVQAIEKAEKTNLPNPLILFEDVYDEMPTRIRSQMNKHYTFLKRNKEHYPISYDSPEKI
Sbjct: 1 MLLNRVFRFTTYCASKFNVLVSLYCTSADKPNFPQSRSEYTSQLNFIYPTDIKGIPLYRVLDGNGNLREDGLDPKFSKEFSIKIIKTMTLLNTMDRILYDSQRQGRISFYMTHYGEEGVQIGSAAALNDGDLIFGQYREAGVGLWRGFTLEEMLNQCYGNKYDSNKGKQMPIHYANKKLNYFSISSVLGTQMPHAVGAAYAFKRAQNGKCVICYFGDGASSVGDAHAALNFSATLDCPVIMLCRNNLYAISTPVHEQYRGDGIGSRGIGYGIATIRVDGNDLIAVYNATKAARELCVNENRPVLIEAMTYRIGSHSTSDDSLAYRSVDEVTWWDKHDNPILRFKFYLKQKNWWSDKEEEAWRNESRKLVVQAIEKAEKTNLPNPLILFEDVYDEMPTRIRSQMNKHYTFLKRNKEHYPISYDSPEKI 427
BLAST of 2-oxoisovalerate dehydrogenase subunit alpha vs. Planmine SMEST
Match: SMESG000021408.1 (SMESG000021408.1) HSP 1 Score: 568.155 bits (1463), Expect = 0.000e+0 Identity = 279/402 (69.40%), Postives = 328/402 (81.59%), Query Frame = 2
Query: 116 TSADKPNFPQSRSEYTSQLNFIYPTDIKGIPLYRVLDGNGNLREDGLDPXXXXXXXXXXXXTMTLLNTMDRILYDSQRQGRISFYMTHYGEEGVQIGSAAALNDGDLIFGQYREAGVGLWRGFTLEEMLNQCYGNKYDSNKGKQMPIHYANKKLNYFSISSVLGTQMPHAVGAAYAFKRAQNGKCVICYFGDGASSVGDAHAALNFSATLDCPVIMLCRNNLYAISTPVHEQXXXXXXXXXXXXXXXATIRVDGNDLIAVYNATKAARELCVNENRPVLIEAMTYRIGSHSTSDDSLAYRSVDEVTWWDKHDNPILRFKFYLKQKNWWSDKEEEAWRNESRKLVVQAIEKAEKTNLPNPLILFEDVYDEMPTRIRSQMNKHYTFLKRNKEHYPISYDSPEKI 1321
S D P FP SRSEYT+ L F++PTDI+GI +YRVL+ G + DP SKE I++ K MTLLN DRI+YDSQRQGRISFYMT++GEEG Q+GSA AL+ DL+FGQYREAGVGLWRG+T+E MLNQCYGNK D KG+QMP+HY NK N FSISS LGTQ+ HA GAAYAFKR QNG C +CYFGDGA+S GDAHAA+NFS+TLDCP+I CRNN YAISTP EQYRGDGI SR GYG+A IRVDGND+ AVYNATKAAR LCVNENRPVLIEAMTYR+GSHSTSDDSLAYRSVDE++WWDKHDNPI R K YL + WWS+ EE+ WR+E+RKLVV+AIEK EK LPNP+ LFEDVYD+MP R+ QM+K Y+F+ +NK+ +P +Y++P+ I
Sbjct: 24 VSIDTPQFPGSRSEYTTHLKFLFPTDIEGISVYRVLNREGQIMGQDNDPNISKETLIEMFKKMTLLNIFDRIMYDSQRQGRISFYMTNFGEEGAQLGSAVALDKNDLVFGQYREAGVGLWRGYTIEGMLNQCYGNKNDFGKGRQMPVHYTNKDANIFSISSPLGTQLLHAAGAAYAFKRNQNGLCTVCYFGDGAASEGDAHAAMNFSSTLDCPMIFFCRNNGYAISTPTSEQYRGDGIASRASGYGMACIRVDGNDIFAVYNATKAARNLCVNENRPVLIEAMTYRVGSHSTSDDSLAYRSVDEISWWDKHDNPISRLKHYLLNQGWWSEGEEKIWRDEARKLVVKAIEKTEKVPLPNPMELFEDVYDKMPQRLYKQMSKQYSFMVKNKDLFPTAYETPKPI 425
BLAST of 2-oxoisovalerate dehydrogenase subunit alpha vs. Planmine SMEST
Match: SMESG000021412.1 (SMESG000021412.1) HSP 1 Score: 400.979 bits (1029), Expect = 7.957e-127 Identity = 207/422 (49.05%), Postives = 294/422 (69.67%), Query Frame = 2
Query: 59 FRFTTYCASKFNVLVSLYCTSAD-KPNFPQSRSEYTSQLNFIYPTDIKGIPLYRVLDGNGNLREDGLDPXXXXXXXXXXXXTMTLLNTMDRILYDSQRQGRISFYMTHYGEEGVQIGSAAALNDGDLIFGQYREAGVGLWRGFTLEEMLNQCYGNKYDSNKGKQMPIHYANKKLNYFSISSVLGTQMPHAVGAAYAFKRAQNGKCVICYFGDGASSVGDAHAALNFSATLDCPVIMLCRNNLYAISTPVHEQXXXXXXXXXXXXXXXATIRVDGNDLIAVYNATKAARELCVNENRPVLIEAMTYRIGSHSTSDDSLAYRSVDEVTWWDKHDNPILRFKFYLKQKNWWSDKEEEAWRNESRKLVVQAIEKAEKTNLPNPLILFEDVYDEMPTRIRSQMNKHYTFLKRNKEHYPISYDSPEKI 1321
+RF ++ + Y S + + +FP + YT++L F + P++++LD NG L + + ++E +K+++TM +LNT D + + Q++ IS Y T +GEEG+QIGSAAAL + D++F QYRE GVGLWRGF +E+MLNQ + NK D N+GKQMPIHY+NK +N+FSISS LGTQMP AVG +Y K + + VICYFG+G +SVGDA ALNF+ATL+CP+I CRNN YAISTP EQY GDG+ +RG G+GI+T++VDGND +AVY ATK ARE + +N+PVLIEAMTYR+G+H+T + +AYR +DEV +W+ +DNP+LRF+ +L + WS ++ + + E R + IE+A+ + NPL+LFEDVYD M ++ QM K FL N+EHYP ++++P I
Sbjct: 8 WRFNVIKSTMLKQVTCFYQKSVETRDHFPPPETIYTNKLKFYDCLNKWNFPIFQILDTNGQLIDPNQEIGITQEDLVKMMQTMIILNTFDILANELQQKKIISLYATSFGEEGLQIGSAAALAENDMVFTQYREPGVGLWRGFDMEDMLNQLFANKDDINRGKQMPIHYSNKDINFFSISSPLGTQMPQAVGYSYMNKIQKKKQGVICYFGEGTASVGDAFVALNFAATLECPIIFFCRNNGYAISTPTDEQYHGDGLAARGCGFGISTLKVDGNDPLAVYLATKTAREFSIEQNQPVLIEAMTYRVGNHTTDEHGIAYRCMDEVKYWELNDNPLLRFQTFLIDRKLWSKEKNKIFHKECRDKINFLIERAQNKSYGNPLVLFEDVYDSMNPILKKQMEKFSKFLALNREHYPGNFENPNPI 429
BLAST of 2-oxoisovalerate dehydrogenase subunit alpha vs. Planmine SMEST
Match: SMESG000069312.1 (SMESG000069312.1) HSP 1 Score: 340.887 bits (873), Expect = 5.066e-102 Identity = 181/318 (56.92%), Postives = 227/318 (71.38%), Query Frame = 3
Query: 2847 PFELPKGCSITRAWFMR*LANEDEVNRS*LLFSLSDEAAYCF*CXXXXXXXXXXXXXXXXASGFSKR*KIEKLIAHENSHSHRKSFTTWKEAEQRIIDGKTLDAYIRTQIQTEKQRW*NVLKRILACIKLLDSQNLALC*KN*SLTAEAGMNFGNFLSLLKLIAEYDPLLESYLKLASESPGSVSYLSPEIQNKFISLLASIVRNKLLKDIK*NEYY*ILLDSTPDLGHRGQLSKV-IRFVDIDFENKTINIKESFLGFIEMHAKDAATFETVIVAKLQSDNIPLDDCRLQCYGNAAVMTGHILSSTEDSC*KSPSPV 3797
PFE G S +WF R LAN DE+N++ LL+S +AYCF CLL S N RS L GF+K K EK+ AHENS +HR SFT WKEAE+RI+ GK +DA ++ Q+Q EKQ+W +VLKR+L+C+K L SQNLAL SL N GNFL+ LKL+AEYDPLL +++ A ++PGSVSYLSP+ QN+ ISLLAS VRNKLL DIK N+YY IL DSTPD HR LS+V +R+V++ F NKT+ IKESFLGFIE+HAKDAAT E VI L++DN+ LDDCR QCY NAA+M+GHI + C ++P +
Sbjct: 150 PFEFRNGRSSHSSWFTRRLANGDEINQTWLLYSPLKSSAYCFCCLLFPKSINNQRSGLTLPEGFNKLRKPEKMSAHENSPTHRASFTAWKEAERRIMSGKGIDAELQAQMQNEKQKWRDVLKRLLSCVKFLASQNLALRGHAESLATNNSSNVGNFLATLKLLAEYDPLLSNHIDHARQNPGSVSYLSPQTQNESISLLASKVRNKLLNDIKRNKYYGILFDSTPDQAHRELLSRVSMRYVNVYFSNKTVTIKESFLGFIELHAKDAATLEHVIADTLEADNLRLDDCRSQCYDNAALMSGHISGLQQRICNRNPRAI 467 HSP 2 Score: 85.1149 bits (209), Expect = 2.146e-16 Identity = 52/120 (43.33%), Postives = 71/120 (59.17%), Query Frame = 1
Query: 3757 LQQRIRARNHRALFVNCDNHSLNLAGVHSTKQDPLVVTFFGTIESIYVFLSFNS----------SMGTTKKCFTHRG*T*I*NMLNA*VEPVNAIYEGLGELVDLLEKLS--DIEKCDTR 4080
LQQRI RN RA+FVNC+NHSLNLAG+HS KQD + VTFF TI+SIY++ S ++ S ++C T +A + V A++ G+ E+V LLE S + + DTR
Sbjct: 455 LQQRICNRNPRAIFVNCNNHSLNLAGMHSAKQDAVAVTFFRTIKSIYLYFSRSTLRWNELKNVISNTVKRECETR---------WSARADAVKAVHNGVNEIVGLLEIFSADNSQTQDTR 565
BLAST of 2-oxoisovalerate dehydrogenase subunit alpha vs. Planmine SMEST
Match: SMESG000049700.1 (SMESG000049700.1) HSP 1 Score: 312.383 bits (799), Expect = 1.130e-93 Identity = 176/362 (48.62%), Postives = 222/362 (61.33%), Query Frame = 3
Query: 2712 IPAVFLFHDLAYLEFDRETQLSIVSQLLRTKIISRGSILFQNKEFPFELPKGCSITRAWFMR*LANEDEVNRS*LLFSLSDEAAYCF*CXXXXXXXXXXXXXXXXASGFSKR*KIEKLIAHENSHSHRKSFTTWKEAEQRIIDGKTLDAYIRTQIQTEKQRW*NVLKRILACIKLLDSQNLALC*KN*SLTAEAGMNFGNFLSLLKLIAEYDPLLESYLKLASESPGSVSYLSPEIQNKFISLLASIVRNKLLKDIK*NEYY*ILLDSTPDLGHRGQLSKVIRFVDIDFENKTINIKESFLGFIEMHAKDAATFETVIVAKLQSDNIPLDDCRLQCYGNAAVMTGHILSSTEDSC*KSPSPV 3797
IP+V +++ YLEFD+ +Q I+SQ L+ +++ RGS FQNK PFE G S+ +WF R LAN DE+NR+ LL+S +AYCF LL S N RS L +K K EK+ AHENS +HR SFT WKEAE+ I+ G SL G N GNFL+ LKL+AEYDPLL ++L A ++PGSVSYLSP+ QN+F+ LLAS VRNKLL DIK N+YY DSTPD HR LS+V R+VD+DF NKT+ IKESFL FIE+HAKDAAT E VIV L++DN+ LDDCR QCY NAA+M+GHI + C ++P +
Sbjct: 37 IPSVLSCNNIGYLEFDKISQRLIISQRLKDELVERGSSAFQNKNGPFEFRDGRSMHSSWFTRRLANGDEINRTRLLYSPLKSSAYCFCGLLFPKSINNQRSGLTLPDDINKWRKPEKMSAHENSPNHRASFTVWKEAERWIMSGHAE-----------------------------------------SLATNNGSNVGNFLATLKLLAEYDPLLFNHLDHARQNPGSVSYLSPQTQNEFMGLLASKVRNKLLNDIKRNKYYGSFFDSTPDQAHREHLSRVKRYVDVDFSNKTVTIKESFLRFIELHAKDAATLEYVIVDTLEADNLRLDDCRSQCYDNAALMSGHISGLQQRICNRNPRAI 357 HSP 2 Score: 94.3597 bits (233), Expect = 1.359e-19 Identity = 53/111 (47.75%), Postives = 70/111 (63.06%), Query Frame = 1
Query: 3757 LQQRIRARNHRALFVNCDNHSLNLAGVHSTKQDPLVVTFFGTIESIYVFLSFNS----------SMGTTKKCFTHRG*T*I*NMLNA*VEPVNAIYEGLGELVDLLEKLSD 4059
LQQRI RN RA+FVNC+N+SLNLAG+HS KQD + VTFFGTIESIY++ S ++ S ++C T +A + V A++ G+ E+V LLEKLSD
Sbjct: 345 LQQRICNRNPRAIFVNCNNYSLNLAGMHSAKQDAVAVTFFGTIESIYLYFSRSTLRWNELKNVISNTVKRECDTR---------WSARADAVKAVHNGVNEIVGLLEKLSD 446 The following BLAST results are available for this feature:
BLAST of 2-oxoisovalerate dehydrogenase subunit alpha vs. Ensembl Human
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Human e!99) Total hits: 5
BLAST of 2-oxoisovalerate dehydrogenase subunit alpha vs. Ensembl Celegans
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99) Total hits: 5
BLAST of 2-oxoisovalerate dehydrogenase subunit alpha vs. Ensembl Fly
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99) Total hits: 5
BLAST of 2-oxoisovalerate dehydrogenase subunit alpha vs. Ensembl Zebrafish
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99) Total hits: 5
BLAST of 2-oxoisovalerate dehydrogenase subunit alpha vs. Ensembl Xenopus
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99) Total hits: 5
BLAST of 2-oxoisovalerate dehydrogenase subunit alpha vs. Ensembl Mouse
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99) Total hits: 4
BLAST of 2-oxoisovalerate dehydrogenase subunit alpha vs. UniProt/SwissProt
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt) Total hits: 5
BLAST of 2-oxoisovalerate dehydrogenase subunit alpha vs. TrEMBL
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL) Total hits: 5
BLAST of 2-oxoisovalerate dehydrogenase subunit alpha vs. Ensembl Cavefish
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99) Total hits: 5
BLAST of 2-oxoisovalerate dehydrogenase subunit alpha vs. Ensembl Sea Lamprey
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99) Total hits: 1
BLAST of 2-oxoisovalerate dehydrogenase subunit alpha vs. Ensembl Yeast
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46) Total hits: 1
BLAST of 2-oxoisovalerate dehydrogenase subunit alpha vs. Ensembl Nematostella
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46) Total hits: 2
BLAST of 2-oxoisovalerate dehydrogenase subunit alpha vs. Ensembl Medaka
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99) Total hits: 5
BLAST of 2-oxoisovalerate dehydrogenase subunit alpha vs. Planmine SMEST
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST) Total hits: 5
Analyses
This transcript is derived from or has results from the following analyses Sequences
The following sequences are available for this feature:
transcript sequence >SMED30010036 ID=SMED30010036|Name=2-oxoisovalerate dehydrogenase subunit alpha|organism=Schmidtea mediterranea sexual|type=transcript|length=4285bpback to top protein sequence of SMED30010036-orf-1 >SMED30010036-orf-1 ID=SMED30010036-orf-1|Name=SMED30010036-orf-1|organism=Schmidtea mediterranea sexual|type=polypeptide|length=428bp MLLNRVFRFTTYCASKFNVLVSLYCTSADKPNFPQSRSEYTSQLNFIYPTback to top protein sequence of SMED30010036-orf-2 >SMED30010036-orf-2 ID=SMED30010036-orf-2|Name=SMED30010036-orf-2|organism=Schmidtea mediterranea sexual|type=polypeptide|length=109bp MHHTSDDENSVATDADDRAIEPIDYMNESQDLSDDEKNLVVVTQDVIPAVback to top Annotated Terms
The following terms have been associated with this transcript:
InterPro
Analysis Name: Schmidtea mediteranean smed_20140614 Interproscan
Date Performed: 2020-05-01
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