testis-expressed protein 52
Overview
Neoblast Clusters
Zeng et. al., 2018▻ Overview▻ Neoblast Population▻ Sub-lethal Irradiated Surviving X1 and X2 Cell Population
Overview
Single cell RNA-seq of pluripotent neoblasts and its early progeniesWe isolated X1 neoblasts cells enriched in high piwi-1 expression (Neoblast Population), and profiled ∼7,614 individual cells via scRNA-seq. Unsupervised analyses uncovered 12 distinct classes from 7,088 high-quality cells. We designated these classes Nb1 to Nb12 and ordered them based on high (Nb1) to low (Nb12) piwi-1 expression levels. We further defined groups of genes that best classified the cells parsed into 12 distinct cell clusters to generate a scaled expression heat map of discriminative gene sets for each cluster. Expression of each cluster’s gene signatures was validated using multiplex fluorescence in situ hybridization (FISH) co-stained with piwi-1 and largely confirmed the cell clusters revealed by scRNA-seq.We also tested sub-lethal irradiation exposure. To profile rare pluripotent stem cells (PSCs) and avoid interference from immediate progenitor cells, we determined a time point after sub-lethal irradiation (7 DPI) with minimal piwi-1+ cells, followed by isolation and single-cell RNA-seq of 1,200 individual cells derived from X1 (Piwi-1 high) and X2 (Piwi-1 low) cell populations (Sub-lethal Irradiated Surviving X1 and X2 Cell Population)Explore this single cell expression dataset with our NB Cluster Shiny App
Neoblast Population
Sub-lethal Irradiated Surviving X1 and X2 Cell Population
Embryonic Expression
Davies et. al., 2017
Hover the mouse over a column in the graph to view average RPKM values per sample. Embryonic Stages: Y: yolk. S2-S8: Stages 2-8. C4: asexual adult. SX: virgin, sexually mature adult. back to top Anatomical Expression
PAGE et. al., 2020SMED30009817 has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGEPAGE Curations: 6
Homology
BLAST of testis-expressed protein 52 vs. Ensembl Human
Match: TEX52 (testis expressed 52 [Source:HGNC Symbol;Acc:HGNC:53643]) HSP 1 Score: 65.855 bits (159), Expect = 2.016e-11 Identity = 40/132 (30.30%), Postives = 63/132 (47.73%), Query Frame = 1 Query: 334 FKLWLEAGKIKPSSLPLNVDVSYNSNMWRNFKHCFLDNQLNKNEDGAIIEEVAKLYPVSVPKPSKMDENSIIKYTESTKLINDPIRKKLILEKLKQNKQLMDQLKLKSLNRNPPLDEQGNIQPPEGYKKYEH 729 F WL+ ++ P++ P D Y+SN+WR D+ ++ S M +NS + + D RKK ++ + + + +++LKL+S R PPLD QGNIQPP +KKY H Sbjct: 95 FHTWLDVCRL-PATFPTQPDRPYDSNVWR----WLTDSNAHRCPPTEHPIPPP----------SWMGQNSFLTFIHCYPTFVDMKRKKQVIFRTVKELKEVEKLKLRSEARAPPLDAQGNIQPPASFKKYRH 211
BLAST of testis-expressed protein 52 vs. Ensembl Mouse
Match: Tex52 (testis expressed 52 [Source:MGI Symbol;Acc:MGI:1918399]) HSP 1 Score: 76.2554 bits (186), Expect = 3.821e-15 Identity = 42/132 (31.82%), Postives = 73/132 (55.30%), Query Frame = 1 Query: 334 FKLWLEAGKIKPSSLPLNVDVSYNSNMWRNFKHCFLDNQLNKNEDGAIIEEVAKLYPVSVPKPSKMDENSIIKYTESTKLINDPIRKKLILEKLKQNKQLMDQLKLKSLNRNPPLDEQGNIQPPEGYKKYEH 729 F WL+ G++ P++ P DV Y+SN+WR+ H ++L + G +P PS M +S + + ++ ++ D R+K I+ + + + +++LKL+S R PPLD GNI PP +KKY++ Sbjct: 98 FHTWLDVGRL-PATFPTRPDVPYDSNVWRHLTHAN-AHRLPAAQPG-------------IPPPSWMGPHSFLSFISASPIVVDLKRRKQIIVRTVKELKEVEKLKLRSELRAPPLDANGNILPPPNFKKYQY 214
BLAST of testis-expressed protein 52 vs. Ensembl Mouse
Match: Tex52 (testis expressed 52 [Source:MGI Symbol;Acc:MGI:1918399]) HSP 1 Score: 73.559 bits (179), Expect = 1.057e-14 Identity = 41/130 (31.54%), Postives = 71/130 (54.62%), Query Frame = 1 Query: 334 FKLWLEAGKIKPSSLPLNVDVSYNSNMWRNFKHCFLDNQLNKNEDGAIIEEVAKLYPVSVPKPSKMDENSIIKYTESTKLINDPIRKKLILEKLKQNKQLMDQLKLKSLNRNPPLDEQGNIQPPEGYKKY 723 F WL+ G++ P++ P DV Y+SN+WR+ H ++L + G +P PS M +S + + ++ ++ D R+K I+ + + + +++LKL+S R PPLD GNI PP +KK+ Sbjct: 98 FHTWLDVGRL-PATFPTRPDVPYDSNVWRHLTHAN-AHRLPAAQPG-------------IPPPSWMGPHSFLSFISASPIVVDLKRRKQIIVRTVKELKEVEKLKLRSELRAPPLDANGNILPPPNFKKH 212
BLAST of testis-expressed protein 52 vs. UniProt/SwissProt
Match: sp|Q3TTI8|TEX52_MOUSE (Testis-expressed protein 52 OS=Mus musculus OX=10090 GN=Tex52 PE=2 SV=1) HSP 1 Score: 76.2554 bits (186), Expect = 2.673e-14 Identity = 42/132 (31.82%), Postives = 73/132 (55.30%), Query Frame = 1 Query: 334 FKLWLEAGKIKPSSLPLNVDVSYNSNMWRNFKHCFLDNQLNKNEDGAIIEEVAKLYPVSVPKPSKMDENSIIKYTESTKLINDPIRKKLILEKLKQNKQLMDQLKLKSLNRNPPLDEQGNIQPPEGYKKYEH 729 F WL+ G++ P++ P DV Y+SN+WR+ H ++L + G +P PS M +S + + ++ ++ D R+K I+ + + + +++LKL+S R PPLD GNI PP +KKY++ Sbjct: 98 FHTWLDVGRL-PATFPTRPDVPYDSNVWRHLTHAN-AHRLPAAQPG-------------IPPPSWMGPHSFLSFISASPIVVDLKRRKQIIVRTVKELKEVEKLKLRSELRAPPLDANGNILPPPNFKKYQY 214
BLAST of testis-expressed protein 52 vs. UniProt/SwissProt
Match: sp|A6NCN8|TEX52_HUMAN (Testis-expressed protein 52 OS=Homo sapiens OX=9606 GN=TEX52 PE=4 SV=2) HSP 1 Score: 65.855 bits (159), Expect = 9.682e-11 Identity = 40/132 (30.30%), Postives = 63/132 (47.73%), Query Frame = 1 Query: 334 FKLWLEAGKIKPSSLPLNVDVSYNSNMWRNFKHCFLDNQLNKNEDGAIIEEVAKLYPVSVPKPSKMDENSIIKYTESTKLINDPIRKKLILEKLKQNKQLMDQLKLKSLNRNPPLDEQGNIQPPEGYKKYEH 729 F WL+ ++ P++ P D Y+SN+WR D+ ++ S M +NS + + D RKK ++ + + + +++LKL+S R PPLD QGNIQPP +KKY H Sbjct: 95 FHTWLDVCRL-PATFPTQPDRPYDSNVWR----WLTDSNAHRCPPTEHPIPPP----------SWMGQNSFLTFIHCYPTFVDMKRKKQVIFRTVKELKEVEKLKLRSEARAPPLDAQGNIQPPASFKKYRH 211
BLAST of testis-expressed protein 52 vs. TrEMBL
Match: A0A0B6ZEU2 (Uncharacterized protein OS=Arion vulgaris OX=1028688 GN=ORF57875 PE=4 SV=1) HSP 1 Score: 123.635 bits (309), Expect = 4.401e-29 Identity = 66/194 (34.02%), Postives = 107/194 (55.15%), Query Frame = 1 Query: 310 ANERKSLEFKLWLEAGKIKPSSLPLNVDVSYNSNMWRNFKHCFLDNQLNKNEDG-AIIEEVAKLYPVSVPKPSKMDENSIIKYTESTKLINDPIRKKLILEKLKQNKQLMDQLKLKSLNRNPPLDEQGNIQPPEGYKKYEHYFFPEPICVADSLNGSADGDPDVFGRVMNKRYKPSVWKLTHKSCNSSYQEVME 888 ++ ++E +LW EAGK +P D SYNSN+WRNF + LN + DG + E VA LYP+++P PS++ + + KY T + + K + + + + L LK ++ RNPPL+E+G+I PPE +KKY H F + PD+FG++ R +P +WKL++K + +Q++ E Sbjct: 61 THQHPTVEHRLWTEAGKTA-VPIPSRPDTSYNSNIWRNFCRQY---GLNVSADGRTMTESVAALYPLNIPAPSQIGDYTFDKYLRETNVFQNKTAKSIAIRRAATDINLFKNLKYRTQARNPPLNEKGDILPPENFKKYAHRFV--SFPSPPPTPPPPEQRPDMFGQLYTPRTRPHMWKLSYKLNHPKFQKLQE 248
BLAST of testis-expressed protein 52 vs. TrEMBL
Match: A0A2T7PKF9 (Uncharacterized protein OS=Pomacea canaliculata OX=400727 GN=C0Q70_05181 PE=4 SV=1) HSP 1 Score: 120.553 bits (301), Expect = 4.310e-28 Identity = 69/211 (32.70%), Postives = 118/211 (55.92%), Query Frame = 1 Query: 256 DCDMVWNDPISPNNSELSANERKSLEFKLWLEAGKIKPSSLPLNVDVSYNSNMWRNFKHCFLDNQLNKNEDGAIIEEVAKLYPVSVPKPSKMDENSIIKYTESTKLINDPIRKKLILEKLKQNKQLMDQLKLKSLNRNPPLDEQGNIQPPEGYKKYEHYFFPEPICVADSLNGSADGDPDVFGRVMNKRYKPSVWKLTHKSCNSSYQEVME 888 DC N +++ S + ++++LWLEAGK P P N D +Y+SN+WRNF+ F +K I + +A +YP+++P PS++++++ +Y + T L D RK + +++++ + Q +LK K+ RNPP+D++G I PPE +KKY H +FP P D+FG+ R P +WKL+HK + ++ + E Sbjct: 41 DCQHFLN-----RSTKTSTHTYPCVQYQLWLEAGKHDPP-FPKNSDTNYDSNVWRNFRRNFGFQTSSKGR--KISDVIATMYPLNIPPPSQLNDHTFDRYIKETALFKDENRKAMAIKQIQSDLQEFRKLKFKTEARNPPIDKKGKILPPENFKKYVHQYFPLPTPPPSPPPPFQKT--DMFGQRYIPRSGPGLWKLSHKLNHPEFKRLQE 241
BLAST of testis-expressed protein 52 vs. TrEMBL
Match: R7UNR0 (Uncharacterized protein OS=Capitella teleta OX=283909 GN=CAPTEDRAFT_208890 PE=4 SV=1) HSP 1 Score: 118.242 bits (295), Expect = 4.178e-27 Identity = 69/203 (33.99%), Postives = 118/203 (58.13%), Query Frame = 1 Query: 307 SANERKSLEFKLWLEAGKIKPSSLPLNVDVSYNSNMWRNFK--HCFLDNQLNKNEDGAIIEEVAKLYPVSVPKPSKMDENSIIKYTESTKLINDPIRKKLILEKLKQNKQLMDQLKLKSLNRNPPLDEQGNIQPPEGYKKYEHYFFP---EPI--CVADSLNGSADGDPDVFGRVM--NKRYKPSVWKLTHKSCNSSYQEVME 888 SA+ S+ ++LW+EAGK + + +P D +YNSN+WRNF+ + F N +N D + +A +YP++VP PS++ + + K+ T I + +KL +++ ++ +L+LK+ +RNPP+D+ GNI+PP ++KY H F P EP+ AD D+FGR + K P +WK+++K N Y++V + Sbjct: 61 SAHGHLSVPYRLWIEAGKHE-APIPDKPDPNYNSNVWRNFQRQYGFYPNTKGQNID----QMIASMYPLNVPAPSRVGQYNYAKFLTETPTIRNEKLRKLAIDRTTKDIVEFKRLRLKTESRNPPIDQTGNIKPPLNFRKYAHRFIPPDAEPVESSTPQPAPNPADTKIDMFGRQVPKGKTSGPYLWKISYKLTNPQYKQVHD 258
BLAST of testis-expressed protein 52 vs. TrEMBL
Match: A0A210QGS3 (Uncharacterized protein OS=Mizuhopecten yessoensis OX=6573 GN=KP79_PYT17961 PE=4 SV=1) HSP 1 Score: 117.472 bits (293), Expect = 7.859e-27 Identity = 70/188 (37.23%), Postives = 107/188 (56.91%), Query Frame = 1 Query: 328 LEFKLWLEAGKIKPSSLPLNVDVSYNSNMWRNFKHCFLDNQLNKNEDGAIIEEV-AKLYPVSVPKPSKMDENSIIKYTESTKLINDPIRKKLILEKLKQNKQLMDQLKLKSLNRNPPLDEQGNIQPPEGYKKYEHYFFPEPICVADSLNGSADGDPDVFGRVMNKRYKPSVWKLTHKSCNSSYQEVME 888 L +KLWLEAGK + + P D +YNSN+WRNF+ + + DG I +V A +YP+++P PS++ ++S K+ + L N+ K L +E+ K + +L++KS RNPPLDE G I PPE +KKYEH F P + A+ D G+ + +P +WKL++K N Y+ V + Sbjct: 70 LGYKLWLEAGKHE-APYPSRPDDNYNSNVWRNFRRQY---GFSATADGRKISDVIASMYPLNIPPPSQVGDHSFDKFIRESSLFNNEKMKSLAMERTKNDVVEFKRLRVKSDARNPPLDESGQIIPPENFKKYEHRFVPP--PLPPPTPPPANQKTDSLGQRYVPKSEPHLWKLSYKLSNPQYEHVRQ 251
BLAST of testis-expressed protein 52 vs. TrEMBL
Match: A0A433TAG4 (Uncharacterized protein OS=Elysia chlorotica OX=188477 GN=EGW08_013666 PE=4 SV=1) HSP 1 Score: 116.701 bits (291), Expect = 1.698e-26 Identity = 69/194 (35.57%), Postives = 108/194 (55.67%), Query Frame = 1 Query: 310 ANERKSLEFKLWLEAGKIKPSSLPLNVDVSYNSNMWRNFKHCFLDNQLNKNEDGAIIEE-VAKLYPVSVPKPSKMDENSIIKYTESTKLINDPIRKKLILEKLKQNKQLMDQLKLKSLNRNPPLDEQGNIQPPEGYKKYEHYFFPEPICVADSLNGSADGDPDVFGRVMNKRYKPSVWKLTHKSCNSSYQEVME 888 +++ S+E +LW+EAGK + P D SYNSN+WRNF+ + L+ +G I E +A +YP+++P S++ EN+ KY TKL D K L + + +L+ K+ RNPPL+E+G+I PP+ YKKY H F P+ D+FG+ R KP +WKL++K + Y+++ E Sbjct: 62 THQQPSVEHRLWIEAGKPA-APFPARPDTSYNSNIWRNFRREY---GLSFKANGRKISEMIASMYPLNIPAASQVRENTFEKYVRETKLFQDEKGKSLAIRRSNTEVSEFKKLRCKTDARNPPLNERGDILPPDNYKKYAHRF--VPVPSPPPSPPPKGQKTDLFGQRYTPRSKPVLWKLSYKLNHPEYRKLRE 249
BLAST of testis-expressed protein 52 vs. Ensembl Nematostella
Match: EDO49159 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7RH47]) HSP 1 Score: 68.5514 bits (166), Expect = 2.254e-13 Identity = 46/163 (28.22%), Postives = 83/163 (50.92%), Query Frame = 1 Query: 325 SLEFKLWLEAGKIKPSSLPLNVDVSYNSNMWRNFKHCFLDN---------------QLNKNEDGAIIE---------EVAKLYPVSVPKPSKMDENSIIKYTESTKLINDPIRKKLILEKLKQNKQ--LMDQLKLKSLNRNPPLDEQGNIQPPEGYKKYEHYF 735 +++ +LWL+ ++ +++ + D YNSNMW+NFK ++ K D +I+ +A +YP+ VP PS++ +N+ K+ KL RK+ + + QN Q + Q+K++S R PPL+ +G I PP+ +++Y H F Sbjct: 45 TVQQRLWLDITELDTTNIE-HKDEQYNSNMWKNFKFVRSKQSAAESSKTLSPQPKERILKQGDARLIDMETDHHVRGNIADIYPLKVPHPSRIGDNTYDKFLGEAKLTE---RKRNRIARQLQNSQDFRIRQMKIRSECRAPPLNWEGEIVPPQTFRRYPHRF 203
BLAST of testis-expressed protein 52 vs. Planmine SMEST
Match: SMESG000070302.1 (SMESG000070302.1) HSP 1 Score: 530.02 bits (1364), Expect = 0.000e+0 Identity = 259/259 (100.00%), Postives = 259/259 (100.00%), Query Frame = 1 Query: 142 MNFQINSAYKKDKIELPKLIHSNKLSTHSRLWIDNYYKDCDMVWNDPISPNNSELSANERKSLEFKLWLEAGKIKPSSLPLNVDVSYNSNMWRNFKHCFLDNQLNKNEDGAIIEEVAKLYPVSVPKPSKMDENSIIKYTESTKLINDPIRKKLILEKLKQNKQLMDQLKLKSLNRNPPLDEQGNIQPPEGYKKYEHYFFPEPICVADSLNGSADGDPDVFGRVMNKRYKPSVWKLTHKSCNSSYQEVMEYKERIVSTTK 918 MNFQINSAYKKDKIELPKLIHSNKLSTHSRLWIDNYYKDCDMVWNDPISPNNSELSANERKSLEFKLWLEAGKIKPSSLPLNVDVSYNSNMWRNFKHCFLDNQLNKNEDGAIIEEVAKLYPVSVPKPSKMDENSIIKYTESTKLINDPIRKKLILEKLKQNKQLMDQLKLKSLNRNPPLDEQGNIQPPEGYKKYEHYFFPEPICVADSLNGSADGDPDVFGRVMNKRYKPSVWKLTHKSCNSSYQEVMEYKERIVSTTK Sbjct: 1 MNFQINSAYKKDKIELPKLIHSNKLSTHSRLWIDNYYKDCDMVWNDPISPNNSELSANERKSLEFKLWLEAGKIKPSSLPLNVDVSYNSNMWRNFKHCFLDNQLNKNEDGAIIEEVAKLYPVSVPKPSKMDENSIIKYTESTKLINDPIRKKLILEKLKQNKQLMDQLKLKSLNRNPPLDEQGNIQPPEGYKKYEHYFFPEPICVADSLNGSADGDPDVFGRVMNKRYKPSVWKLTHKSCNSSYQEVMEYKERIVSTTK 259 The following BLAST results are available for this feature:
BLAST of testis-expressed protein 52 vs. Ensembl Human
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Human e!99) Total hits: 1
BLAST of testis-expressed protein 52 vs. Ensembl Celegans
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99) Total hits: 0
BLAST of testis-expressed protein 52 vs. Ensembl Fly
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99) Total hits: 0
BLAST of testis-expressed protein 52 vs. Ensembl Zebrafish
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99) Total hits: 0
BLAST of testis-expressed protein 52 vs. Ensembl Xenopus
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99) Total hits: 0
BLAST of testis-expressed protein 52 vs. Ensembl Mouse
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99) Total hits: 2
BLAST of testis-expressed protein 52 vs. UniProt/SwissProt
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt) Total hits: 2
BLAST of testis-expressed protein 52 vs. TrEMBL
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL) Total hits: 5
BLAST of testis-expressed protein 52 vs. Ensembl Cavefish
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99) Total hits: 0
BLAST of testis-expressed protein 52 vs. Ensembl Sea Lamprey
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99) Total hits: 0
BLAST of testis-expressed protein 52 vs. Ensembl Yeast
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46) Total hits: 0
BLAST of testis-expressed protein 52 vs. Ensembl Nematostella
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46) Total hits: 1
BLAST of testis-expressed protein 52 vs. Ensembl Medaka
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99) Total hits: 0
BLAST of testis-expressed protein 52 vs. Planmine SMEST
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST) Total hits: 1
Analyses
This transcript is derived from or has results from the following analyses Sequences
The following sequences are available for this feature:
transcript sequence >SMED30009817 ID=SMED30009817|Name=testis-expressed protein 52|organism=Schmidtea mediterranea sexual|type=transcript|length=1083bpback to top protein sequence of SMED30009817-orf-1 >SMED30009817-orf-1 ID=SMED30009817-orf-1|Name=SMED30009817-orf-1|organism=Schmidtea mediterranea sexual|type=polypeptide|length=260bp MNFQINSAYKKDKIELPKLIHSNKLSTHSRLWIDNYYKDCDMVWNDPISPback to top Annotated Terms
The following terms have been associated with this transcript:
InterPro
Analysis Name: Schmidtea mediteranean smed_20140614 Interproscan
Date Performed: 2020-05-01
|