Copper-transporting ATPase 1

Query:  109 RMKVDGMTCMSCVRNIEENLMKFTGVCGIMVSLLHAEATVIFDADIATVEDISNKIDEMGFDVTVKSSEVSNVKDKVVRSRIKFESDINKSVEKSIETSLSSKLLLVRFCQENNYADIWHYSSIRSTEILSVIQQSEIYGVLVLEQCPTIRVIVRVNGMTCQSCVDNIESTVGKKQGIISIKVFLEKSEAHALVDASLAGP-DVEEMINDMGFNSEMILEIFNDSCAGKPNN----VSQKYEELKSNTIYPILSTTIV-IKALKSIFCIFKIENHMRALPGVDKCSVNLIEEIGMIDYDSGKWNVQKIREEIESLGY----------------------------------------LTELPKQNWNSTRQSSAVSLNEESRSKCYLRITGMTCSSCVNKVESHLLKVEGVKSVLVALLAMKCEIIYDSAYVMPFQLSNRVKELGFNAEVIENGNEGIGIVNVLIRGMTCSSCVNHIENHISKIKGIASINVSLSTSKGKVEYFISECGPRDVIDAINDMGFDASLCDHLESNHAAADHINQMIKQWRSSFFFSLICGIPXXXXXXXXXXXXXXXXHTIIHENGSNRTIM--KSTVPMVCSGLSADNLILFVLATPVQFYGARYFYIQAYLSLKHKTTNMDVLVVMATXXXXXXXXXXXXXXMAFRRNTSPKTFFETSPMLIVFLSLGRWLEHIAKGKTSEALTKLMSLQAVEATLYT--PEN---KERKIPINLVQRNDLIKILPGEKIPVDGKVVTGTSTCDESLITGESMPIEKTHGSDVIGGSINKSGMLIVKATHVGSDSALAQIVKLVEEAQTSKAPIQQLADRIAGMFVPSVLICAIITLIIWVIVGFSKPEILPKYV----NELSVTEITWEHAFQLAITVLSIACPCSLGLXXXXXXXXXXXXXXXNGILIKGGEPLENIHKLNVIVFDKTGTITNGSPSVTRFLVLIGNGVREHIDKLLKILAAAESASEHPIGKAIITFSKARISNENLPEVLESSAVSGCGLGCKLNLDPKTEVTKFVKNLINIESPSEETNILGQXXXXXXXXXXXXTYKDVIFPVRQHMAWTSDLCQTVTVIIGNRNWMLRNGILVDDEVDELMSEDENLGRTVILMAIDNELIAMISVADQVKREAALAVYTLKKMNIEVYLMTGDNSKTATAIARQVGIHYVFAEVLPSHKVAKVQQLQNTNRSLTSKRKMKVAMVGDGINDSPALAQSDVGIAIGTGTDVAVEAADVVLIRNSLLDVIAAIQLSKATVKRIRQNFIAATLYNLLGIPIAAGVLMPIGIEMMPWMXXXXXXXXXXXXXXXXXXXXXWKKPSEEKLITPEYINFIQSSGLSESQIIVRRGID 4008
            +++V+GMTC SCV +IE  + K  GV  + VSL + EA + +   +   ED+ + +++MGF+  +KS        KV    +    DI +    + +  LSS          NN   + H  S                 V+ L+        +R++GM C+SCV NIE  +G+  G+ SI+V LE   A    D S   P  ++  I  +   +  +     D   G   +     S        N +    STT++ I  +    C+  IE  +  L GV + SV+L E    + Y+    + +++R  IE +G+                                           LP  +       S  S    +  KC+L+I GMTC+SCV+ +E +L K  GV SVLVAL+A K EI YD   + P +++  +++LGF A V+E+     G + + I GMTC+SCV++IE+ +++  GI   +V+L+TSK  V++     GPRD+I  I ++GF ASL     + H   DH    IKQW+ SF  SL+ GIP M +M+          + +I  N  +++++   + +P    GLS  NLI F+L T VQ  G  YFY+QAY SL+H++ NMDVL+V+ATSI+Y+YS++++V+++A +   SP TFF+T PML VF++LGRWLEH+AK KTSEAL KLMSLQA EAT+ T   +N   +E ++P+ LVQR D++K++PG K PVDGKV+ G +  DESLITGE+MP+ K  GS VI GSIN  G +++KATHVG+D+ LAQIVKLVEEAQ SKAPIQQLADR +G FVP ++I + +TL++W+++GF    ++ +Y       +S TE+    AFQ +ITVL IACPCSLGLATPTAVMVGTGV A NGILIKGG+PLE  HK+  ++FDKTGTIT+G P V R L L+G+     + K+L ++  AE++SEHP+G A+  + K  +  E L    +  AV GCG+GCK            V N+  I + SE    L    +           KD +              QT +V+IGNR W+ RNG+ +  +V + M++ E  G+T IL+AID  L  MI++AD VK+EAALAV+TL+ M ++V L+TGDN KTA AIA QVGI+ VFAEVLPSHKVAKVQ+LQN  +        KVAMVGDG+NDSPALAQ+D+G+AIGTGTDVA+EAADVVLIRN LLDV+A+I LSK TV+RIR N + A +YNL+GIPIAAGV MPIGI + PWM SAAMAASSVSVV  SL LK +KKP  E+    E         L+ SQ+ V  G+D
Sbjct:  146 KLRVEGMTCQSCVSSIEGKVRKLQGVVRVKVSLSNQEAVITYQPYLIQPEDLRDHVNDMGFEAAIKS--------KVAPLSLG-PIDIERLQSTNPKRPLSSA-----NQNFNNSETLGHQGS----------------HVVTLQ--------LRIDGMHCKSCVLNIEENIGQLLGVQSIQVSLENKTAQVKYDPSCTSPVALQRAIEALPPGNFKVS--LPDGAEGSGTDHRSSSSHSPGSPPRNQVQGTCSTTLIAIAGMTCASCVHSIEGMISQLEGVQQISVSLAEGTATVLYNPSVISPEELRAAIEDMGFEASVVSESCSTNPLGNHSAGNSMVQTTDGTPTSVQEVAPHTGRLPANHAPDILAKSPQSTRAVAPQKCFLQIKGMTCASCVSNIERNLQKEAGVLSVLVALMAGKAEIKYDPEVIQPLEIAQFIQDLGFEAAVMEDYAGSDGNIELTITGMTCASCVHNIESKLTRTNGITYASVALATSKALVKFDPEIIGPRDIIKIIEEIGFHASLAQRNPNAHHL-DH-KMEIKQWKKSFLCSLVFGIPVMALMI----------YMLIPSNEPHQSMVLDHNIIP----GLSILNLIFFILCTFVQLLGGWYFYVQAYKSLRHRSANMDVLIVLATSIAYVYSLVILVVAVAEKAERSPVTFFDTPPMLFVFIALGRWLEHLAKSKTSEALAKLMSLQATEATVVTLGEDNLIIREEQVPMELVQRGDIVKVVPGGKFPVDGKVLEGNTMADESLITGEAMPVTKKPGSTVIAGSINAHGSVLIKATHVGNDTTLAQIVKLVEEAQMSKAPIQQLADRFSGYFVPFIIIMSTLTLVVWIVIGFIDFGVVQRYFPNPNKHISQTEVIIRFAFQTSITVLCIACPCSLGLATPTAVMVGTGVAAQNGILIKGGKPLEMAHKIKTVMFDKTGTITHGVPRVMRVL-LLGDVATLPLRKVLAVVGTAEASSEHPLGVAVTKYCKEELGTETLGYCTDFQAVPGCGIGCK------------VSNVEGILAHSERP--LSAPASHLNEAGSLPAEKDAV-------------PQTFSVLIGNREWLRRNGLTISSDVSDAMTDHEMKGQTAILVAIDGVLCGMIAIADAVKQEAALAVHTLQSMGVDVVLITGDNRKTARAIATQVGINKVFAEVLPSHKVAKVQELQNKGK--------KVAMVGDGVNDSPALAQADMGVAIGTGTDVAIEAADVVLIRNDLLDVVASIHLSKRTVRRIRINLVLALIYNLVGIPIAAGVFMPIGIVLQPWMGSAAMAASSVSVVLSSLQLKCYKKPDLERY---EAQAHGHMKPLTASQVSVHIGMD 1407          

Query:  568 VRVNGMTCQSCVDNIESTVGKKQGIISIKVFLEKSEAHA-LVDASLAGPDVEEMINDMGFNSEMILEIFNDSCAGKPNNVSQKYEELKSNTIYPILSTTIVIKALKSIFCIFKIENHMRALPGVDKCSVNLIEEIGMIDYDSGKWNVQKIREEIESLGYLTEL---------------------PKQNWNSTRQS--SAVSLNEESRS--KCYLRITGMTCSSCVNKVESHLLKVEGVKSVLVALLAMKCEIIYDSAYVMPFQLSNRVKEL--GFNAEVIENGNEGIGIVN------------------------VLIRGMTCSSCVNHIENHISKIKGIASINVSLSTSKGKVEYFISECGPRDVIDAINDMGFDASLCDHLESNHAAADH 1587
            VR+ GMTCQSCV +IE  +   +GIIS+KV LE+  A    V + +    V   I DMGF +     I     A  P+      E +            + ++ +    C+  IE  +R L GV +  V+L  +  +I Y       + +R+ +  +G+   +                     PK+  +S  Q+  ++ +L  +        LRI GM C SCV  +E ++ ++ GV+S+ V+L     ++ YD +   P  L   ++ L  G     + +G EG G  +                        + I GMTC+SCV+ IE  IS+++G+  I+VSL+     V Y  S   P ++  AI DMGF+AS+     S +   +H
Sbjct:   62 VRILGMTCQSCVKSIEDRISNLKGIISMKVSLEQGSATVKYVPSVVCLQQVCHQIGDMGFEAS----IAEGKAASWPSRSLPAQEAV----------VKLRVEGMTCQSCVSSIEGKVRKLQGVVRVKVSLSNQEAVITYQPYLIQPEDLRDHVNDMGFEAAIKSKVAPLSLGPIDIERLQSTNPKRPLSSANQNFNNSETLGHQGSHVVTLQLRIDGMHCKSCVLNIEENIGQLLGVQSIQVSLENKTAQVKYDPSCTSPVALQRAIEALPPGNFKVSLPDGAEGSGTDHRSSSSHSPGSPPRNQVQGTCSTTLIAIAGMTCASCVHSIEGMISQLEGVQQISVSLAEGTATVLYNPSVISPEELRAAIEDMGFEASVVSESCSTNPLGNH 439          

Query:  562 VIVRVNGMTCQSCVDNIESTVGKKQGIISIKVFLEKSEAHALVDASLAGP-DVEEMINDMGFNSEMI------------LEIFNDSCAGKP-NNVSQKY--EELKSNTIYPILSTTIVIKALKSIFCIFKIENHMRALPGVDKCSVNLIEEIGMIDYDSGKWNVQKIREEIESLGYLTELPKQNWNSTRQSSAVSLNEESR-------------------SKCYLRITGMTCSSCVNKVESHLLKVEGVKSVLVALLAMKCEIIYDSAYVMPFQLSNRVKELGFNAEVIEN-------GNEGIGIVNVLIR------------------------------------------------GMTCSSCVNHIENHISKIKGIASINVSLSTSKGKVEYFISECGPRDVIDAINDMGFDASLCDHLESNHAAAD 1584
            V +RV GMTCQSCV +IE  V K QG++ +KV L   EA       L  P D+ + +NDMGF + +             +E    +   +P ++ +Q +   E   +    +++  + I  +    C+  IE ++  L GV    V+L  +   + YD    +   ++  IE+      LP  N+  +    A     + R                   S   + I GMTC+SCV+ +E  + ++EGV+ + V+L      ++Y+ + + P +L   ++++GF A V+         GN   G  N +++                                                GMTC+SCV++IE ++ K  G+ S+ V+L   K +++Y      P ++   I D+GF+A++ +    ++A +D
Sbjct:  145 VKLRVEGMTCQSCVSSIEGKVRKLQGVVRVKVSLSNQEAVITYQPYLIQPEDLRDHVNDMGFEAAIKSKVAPLSLGPIDIERLQSTNPKRPLSSANQNFNNSETLGHQGSHVVTLQLRIDGMHCKSCVLNIEENIGQLLGVQSIQVSLENKTAQVKYDPSCTSPVALQRAIEA------LPPGNFKVSLPDGAEGSGTDHRSSSSHSPGSPPRNQVQGTCSTTLIAIAGMTCASCVHSIEGMISQLEGVQQISVSLAEGTATVLYNPSVISPEELRAAIEDMGFEASVVSESCSTNPLGNHSAG--NSMVQTTDGTPTSVQEVAPHTGRLPANHAPDILAKSPQSTRAVAPQKCFLQIKGMTCASCVSNIERNLQKEAGVLSVLVALMAGKAEIKYDPEVIQPLEIAQFIQDLGFEAAVME----DYAGSD 563          

Query:  100 GSARMKVDGMTCMSCVRNIEENLMKFTGVCGIMVSLLHAEATVIFDADIATVEDISNKIDEMGFDVTV 303
            G+  + + GMTC SCV NIE  L +  G+    V+L  ++A V FD +I    DI   I+E+GF  ++
Sbjct:  564 GNIELTITGMTCASCVHNIESKLTRTNGITYASVALATSKALVKFDPEIIGPRDIIKIIEEIGFHASL 631          

Query:  574 VNGMTCQSCVDNIESTVGKKQGIISIKVFLEKSEAHALVDASLAGPDVEEMINDMGFNSEMILEIFNDSCAGKPNNVSQKYEELKSNTI-YPILSTTIV-IKALKSIFCIFKIENHMRALPGVDKCSVNLIEEIGMIDYDSGKWNVQKIREEIESLGY-----------------LTELP---KQNWNSTRQSSAVSLNEESR--SKCYLRITGMTCSSCVNKVESHLLKVEGVKSVLVALLAMKCEIIYDSAYVMPFQLSNRVKELGFNAEVIENGNEGIGIVNVLIRGMTCSSCVNHIENHISKIKGIASINVSLSTSKGKVEYFISECGPRDVIDAINDMGFDASLCDHLESNHAAADHINQMIKQWRSSFFFSLICGIPXXXXXXXXXXXXXXXXHTIIHENGSNRTIMKSTVPM-----VCSGLSADNLILFVLATPVQFYGARYFYIQAYLSLKHKTTNMDVLVVMATXXXXXXXXXXXXXXMAFRRNTSPKTFFETSPMLIVFLSLGRWLEHIAKGKTSEALTKLMSLQAVEATLYTPEN-----KERKIPINLVQRNDLIKILPGEKIPVDGKVVTGTSTCDESLITGESMPIEKTHGSDVIGGSINKSGMLIVKATHVGSDSALAQIVKLVEEAQTSKAPIQQLADRIAGMFVPSVLICAIITLIIWVIVGFSKPEI----LPKYVNELSVTEITWEHAFQLAITVLSIACPCSLGLXXXXXXXXXXXXXXXNGILIKGGEPLENIHKLNVIVFDKTGTITNGSPSVTRFLVLI-GNGVREHIDKLLKILAAAESASEHPIGKAIITFSKARISNENLPEVLESSAVSGCGLGCKLNLDPKTEVTKFV-KNLINIESPSEETNILGQXXXXXXXXXXXXTYKDVIFPVRQHMAWTSDLCQTVTVIIGNRNWMLRNGILVDDEVDELMSEDENLGRTVILMAIDNELIAMISVADQVKREAALAVYTLKKMNIEVYLMTGDNSKTATAIARQVGIHYVFAEVLPSHKVAKVQQLQNTNRSLTSKRKMKVAMVGDGINDSPALAQSDVGIAIGTGTDVAVEAADVVLIRNSLLDVIAAIQLSKATVKRIRQNFIAATLYNLLGIPIAAGVLMPIGIEMMPWMXXXXXXXXXXXXXXXXXXXXXWKKPSEEKLITPEYINFIQSSGLSESQIIVRRGID 4008
            ++GM C+SCV NIEST+   Q + SI V LE   A    +AS   P+      +        + I ++  +   +  S   +++  N +  P+   T++ I  +    C+  IE  +   PGV    V+L    G ++YD    + + +R  IE +G+                  +E+P     N   T+  + V   EE +  SKCY+++TGMTC+SCV  +E +L + EG+ S+LVAL+A K E+ Y+ A + P  ++  ++ELGF A VIEN +EG G++ +++RGMTC+SCV+ IE+ ++K +GI   +V+L+T+K  ++Y     GPRD+I  I  +GF+ASL    + + +  DH  + I+QWR SF  SL   IP M +M++ M           ++N S   ++     M     +  GLS  NL+ F+L  PVQF+G  YFYIQAY +LKHKT NMDVL+V+AT+I++ YS+I+++++M  R   +P TFF+T PML VF++LGRWLEHIAKGKTSEAL KL+SLQA EAT+ T ++      E ++ + LVQR D+IK++PG K PVDG+V+ G S  DESLITGE+MP+ K  GS VI GSIN++G L++ ATHVG+D+ L+QIVKLVEEAQTSKAPIQQ AD+++G FVP ++  +I TL++W+++GF   EI     P Y   +S TE     AFQ +ITVL IACPCSLGLATPTAVMVGTGVGA NGILIKGGEPLE  HK+ V+VFDKTGTIT+G+P V +  VL   N +  H  K+L I+  AES SEHP+G AI  + K  +  E L   ++   V GCG+ CK+     T +   + KN  NIE  + +   L Q    N       +   +I   +   A  +   Q   V+IGNR WM+RNG++++++V++ M+E E  GRT +L+A+D+EL  +I++AD VK EA LA++ LK M +EV LMTGDNSKTA +IA QVGI  VFAEVLPSHKVAKV+QLQ   +        +VAMVGDGINDSPALA ++VGIAIGTGTDVA+EAADVVLIRN LLDV+A+I LS+ TVKRIR NF+ A +YNL+GIPIAAGV MPIG+ + PWM SAAMAASSVSVV  SL LKL++KP+ E    P      Q    S S+I V  GID
Sbjct:  283 IDGMHCKSCVSNIESTLSALQYVSSIVVSLENRSAIVKYNASSVTPESLRKAIEAVSPGLYRVSITSEVESTSNSPSSSSLQKIPLNVVSQPLTQETVINIDGMTCNSCVQSIEGVISKKPGVKSIRVSLANSNGTVEYDPLLTSPETLRGAIEDMGFDATLSDTNEPLVVIAQPSSEMPLLTSTNEFYTKGMTPVQDKEEGKNSSKCYIQVTGMTCASCVANIERNLRREEGIYSILVALMAGKAEVRYNPAVIQPPMIAEFIRELGFGATVIENADEGDGVLELVVRGMTCASCVHKIESSLTKHRGILYCSVALATNKAHIKYDPEIIGPRDIIHTIESLGFEASLVKK-DRSASHLDH-KREIRQWRRSFLVSLFFCIPVMGLMIYMMVMDHHFATLHHNQNMSKEEMINLHSSMFLERQILPGLSVMNLLSFLLCVPVQFFGGWYFYIQAYKALKHKTANMDVLIVLATTIAFAYSLIILLVAMYERAKVNPITFFDTPPMLFVFIALGRWLEHIAKGKTSEALAKLISLQATEATIVTLDSDNILLSEEQVDVELVQRGDIIKVVPGGKFPVDGRVIEGHSMVDESLITGEAMPVAKKPGSTVIAGSINQNGSLLICATHVGADTTLSQIVKLVEEAQTSKAPIQQFADKLSGYFVPFIVFVSIATLLVWIVIGFLNFEIVETYFPGYNRSISRTETIIRFAFQASITVLCIACPCSLGLATPTAVMVGTGVGAQNGILIKGGEPLEMAHKVKVVVFDKTGTITHGTPVVNQVKVLTESNRISHH--KILAIVGTAESNSEHPLGTAITKYCKQELDTETLGTCIDFQVVPGCGISCKV-----TNIEGLLHKNNWNIEDNNIKNASLVQIDASNEQSSTSSS---MIIDAQISNALNA---QQYKVLIGNREWMIRNGLVINNDVNDFMTEHERKGRTAVLVAVDDELCGLIAIADTVKPEAELAIHILKSMGLEVVLMTGDNSKTARSIASQVGITKVFAEVLPSHKVAKVKQLQEEGK--------RVAMVGDGINDSPALAMANVGIAIGTGTDVAIEAADVVLIRNDLLDVVASIDLSRKTVKRIRINFVFALIYNLVGIPIAAGVFMPIGLVLQPWMGSAAMAASSVSVVLSSLFLKLYRKPTYESYELPARSQIGQK---SPSEISVHVGID 1441          

Query:   91 MKLGSARMKVDGMTCMSCVRNIEENLMKFTGVCGIMVSLLHAEATVIFDADIATVEDISNKIDEMGFDVTVKSSE----VSNVKDKVVRSRIKFESDINKSVEKSIETSLSSKLLLVRFCQENNYADIWHYSSIRS---TEILSVIQQSEI----------YGVL----------VLEQCPTIRVIVRVNGMTCQSCVDNIESTVGKKQGIISIKVFLEKSEAHALVDASLAGPDVEEM---INDMGFNSEM--------ILEIFNDSCAGKPNNVSQKYEELKSNTIYPILSTTIVIKALKSIFCIFKIENHMRALPGVDKCSVNLIEEIGMIDYDSGKWNVQKIREEIESLG---YLTELPKQ-----NWNSTRQSSAVSLNEESR---SKCYLRITGMTCSSCVNKVESHLLKVEGVKSVLVALLAMKCEIIYDSAYVMPFQLSNRVKELGFNAEVIENGNEGIGIVN------------------------------------VLIRGMTCSSCVNHIENHISKIKGIASINVSLSTSKGKVEYFISECGPRDVIDAINDMGFDASLCDHLE 1563
            M + S  + V+GMTC SCV  IE+ + K  GV  I VSL    AT+I+D  + T + +   ID+MGFD  + + +    +++     V + +    D            + S LL     +     DI  Y   R+   T I S++  ++I           G L           + Q   + + ++V GMTC SC   IE  +GK QG+  IKV L+  EA  +    L    VEEM   I  MGF + +        +  I  +     P   S+  ++ +S +     + T +I  +    C+  IE+ + AL  V    V+L     ++ Y++     + +R+ IE++    Y   +  +     N  S+     + LN  S+    +  + I GMTC+SCV  +E  + K  GVKS+ V+L      + YD     P  L   ++++GF+A  + + NE + ++                                     + + GMTC+SCV +IE ++ + +GI SI V+L   K +V Y  +   P  + + I ++GF A++ ++ +
Sbjct:    5 MGVNSVTISVEGMTCNSCVWTIEQQIGKVNGVHHIKVSLEEKNATIIYDPKLQTPKTLQEAIDDMGFDAVIHNPDPLPVLTDTLFLTVTASLTLPWD-----------HIQSTLL-----KTKGVTDIKIYPQKRTVAVTIIPSIVNANQIKELVPELSLDTGTLEKKSGACEDHSMAQAGEVVLKMKVEGMTCHSCTSTIEGKIGKLQGVQRIKVSLDNQEATIVYQPHLI--SVEEMKKQIEAMGFPAFVKKQPKYLKLGAIDVERLKNTPVKSSEGSQQ-RSPSYTNDSTATFIIDGMHCKSCVSNIESTLSALQYVSSIVVSLENRSAIVKYNASSVTPESLRKAIEAVSPGLYRVSITSEVESTSNSPSSSSLQKIPLNVVSQPLTQETVINIDGMTCNSCVQSIEGVISKKPGVKSIRVSLANSNGTVEYDPLLTSPETLRGAIEDMGFDA-TLSDTNEPLVVIAQPSSEMPLLTSTNEFYTKGMTPVQDKEEGKNSSKCYIQVTGMTCASCVANIERNLRREEGIYSILVALMAGKAEVRYNPAVIQPPMIAEFIRELGFGATVIENAD 560          

Query:  109 RMKVDGMTCMSCVRNIEENLMKFTGVCGIMVSLLHAEATVIFDADIATVEDISNKIDEMGFDVTVKSS---------EVSNVKDKVVRS----RIKFESDINKSVE---------KSIETSLSSKLLLVRFCQ------ENNYADI-WHYSSIRSTEILSVIQ--QSEIYGVLV---------------LEQCP--------TIRVIVRVNGMTCQSCVDNIESTVGKKQGIISIKVFLEKSEAHALVDASLAGPD-VEEMINDMGFN-----------------SEMILEIFNDSCAGKPNNVSQKYEELKSNTIYPILSTTIVIKALKSIFCIFKIENHMRALPGVDKCSVNLIEEIGMIDYDSGKWNVQKIREEIESLGYLTELPKQNWNSTRQSSAVSLNEESRSKCYLRITGMTCSSCVNKVESHLLKVEGVKSVLVALLAMKCEIIYDSAYVMPFQLSNRVKELGFNAEVIE 1326
            +MKV+GMTC SC   IE  + K  GV  I VSL + EAT+++   + +VE++  +I+ MGF   VK           +V  +K+  V+S    + +  S  N S           KS  +++ S L  +++        EN  A + ++ SS+    +   I+     +Y V +               L++ P        T   ++ ++GMTC SCV +IE  + KK G+ SI+V L  S      D  L  P+ +   I DMGF+                 SEM L    +    K     Q  EE K+++        I +  +    C+  IE ++R   G+    V L+     + Y+        I E I  LG+              ++ +   +E      L + GMTC+SCV+K+ES L K  G+    VAL   K  I YD   + P  + + ++ LGF A +++
Sbjct:  174 KMKVEGMTCHSCTSTIEGKIGKLQGVQRIKVSLDNQEATIVYQPHLISVEEMKKQIEAMGFPAFVKKQPKYLKLGAIDVERLKNTPVKSSEGSQQRSPSYTNDSTATFIIDGMHCKSCVSNIESTLSALQYVSSIVVSLENRSAIVKYNASSVTPESLRKAIEAVSPGLYRVSITSEVESTSNSPSSSSLQKIPLNVVSQPLTQETVINIDGMTCNSCVQSIEGVISKKPGVKSIRVSLANSNGTVEYDPLLTSPETLRGAIEDMGFDATLSDTNEPLVVIAQPSSEMPLLTSTNEFYTKGMTPVQDKEEGKNSS-----KCYIQVTGMTCASCVANIERNLRREEGIYSILVALMAGKAEVRYNPAVIQPPMIAEFIRELGF-------------GATVIENADEGDGVLELVVRGMTCASCVHKIESSLTKHRGILYCSVALATNKAHIKYDPEIIGPRDIIHTIESLGFEASLVK 633          

Query:  562 VIVRVNGMTCQSCVDNIESTVGKKQGIISIKVFLEKSEAHALVDASLAGP-DVEEMINDMGFNSEMILEIFNDSCAGKPNNVSQKYEELKS-NTIYPILST--------TIVIKALKSIFCIFKIENH---MRALPGVDKCSVNLIEEIGMIDYDSGKWNVQKIREEIESLGY----------------------------------------LTELPKQNWNSTRQSSAVSLNEESRSKCYLRITGMTCSSCVNKVESHLLKVEGVKSVLVALLAMKCEIIYDSAYVMPFQLSNRVKELGFNAEVIENGNEGIGIVNVLIRGMTCSSCVNHIENHISKIKGIASINVSLSTSKGKVEYFISECGPRDVIDAINDMGFDASLCDHLESNHAAADHINQMIKQWRSSFFFSLICGIPXXXXXXXXXXXXXXXXHTIIHENGSNRTIM--KSTVPMVCSGLSADNLILFVLATPVQFYGARYFYIQAYLSLKHKTTNMDVLVVMATXXXXXXXXXXXXXXMAFRRNTSPKTFFETSPMLIVFLSLGRWLEHIAKGKTSEALTKLMSLQAVEATLYT--PEN---KERKIPINLVQRNDLIKILPGEKIPVDGKVVTGTSTCDESLITGESMPIEKTHGSDVIGGSINKSGMLIVKATHVGSDSALAQIVKLVEEAQTSKAPIQQLADRIAGMFVPSVLICAIITLIIWVIVGFSKPEILPKYV----NELSVTEITWEHAFQLAITVLSIACPCSLGLXXXXXXXXXXXXXXXNGILIKGGEPLENIHKLNVIVFDKTGTITNGSPSVTRFLVLIGNGVREHIDKLLKILAAAESASEHPIGKAIITFSKARISNENLPEVLESSAVSGCGLGCKLNLDPKTEVTKFVKNLINIESPSEETNILGQXXXXXXXXXXXXTYKDVIFPVRQHMAWTSDLCQTVTVIIGNRNWMLRNGILVDDEVDELMSEDENLGRTVILMAIDNELIAMISVADQVKREAALAVYTLKKMNIEVYLMTGDNSKTATAIARQVGIHYVFAEVLPSHKVAKVQQLQNTNRSLTSKRKMKVAMVGDGINDSPALAQSDVGIAIGTGTDVAVEAADVVLIRNSLLDVIAAIQLSKATVKRIRQNFIAATLYNLLGIPIAAGVLMPIGIEMMPWMXXXXXXXXXXXXXXXXXXXXXWKKPSEEKLITPEYINFIQSSGLSESQIIVRRGID 4008
            V +RV GMTCQSCV +IE  V K QG++ +KV L   EA       L  P D+ + +NDMGF + +  ++   S    P ++    E L+S N   P+ S         T+  +    +    +I+     +  L GV + SV+L E    + Y+    + +++R  IE +G+                                           LP  +       S  S    +  KC+L+I GMTC+SCV+ +E +L K  GV SVLVAL+A K EI YD   + P +++  +++LGF A V+E+     G + + I GMTC+SCV++IE+ +++  GI   +V+L+TSK  V++     GPRD+I  I ++GF ASL     + H   DH    IKQW+ SF  SL+ GIP M +M+          + +I  N  +++++   + +P    GLS  NLI F+L T VQ  G  YFY+QAY SL+H++ NMDVL+V+ATSI+Y+YS++++V+++A +   SP TFF+T PML VF++LGRWLEH+AK KTSEAL KLMSLQA EAT+ T   +N   +E ++P+ LVQR D++K++PG K PVDGKV+ G +  DESLITGE+MP+ K  GS VI GSIN  G +++KATHVG+D+ LAQIVKLVEEAQ SKAPIQQLADR +G FVP ++I + +TL++W+++GF    ++ +Y       +S TE+    AFQ +ITVL IACPCSLGLATPTAVMVGTGV A NGILIKGG+PLE  HK+  ++FDKTGTIT+G P V R L L+G+     + K+L ++  AE++SEHP+G A+  + K  +  E L    +  AV GCG+GCK            V N+  I + SE    L    +           KD +              QT +V+IGNR W+ RNG+ +  +V + M++ E  G+T IL+AID  L  MI++AD VK+EAALAV+TL+ M ++V L+TGDN KTA AIA QVGI+ VFAEVLPSHKVAKVQ+LQN  +        KVAMVGDG+NDSPALAQ+D+G+AIGTGTDVA+EAADVVLIRN LLDV+A+I LSK TV+RIR N + A +YNL+GIPIAAGV MPIGI + PWM SAAMAASSVSVV  SL LK +KKP  E+    E         L+ SQ+ V  G+D
Sbjct:  145 VKLRVEGMTCQSCVSSIEGKVRKLQGVVRVKVSLSNQEAVITYQPYLIQPEDLRDHVNDMGFEAAIKSKVAPLSLG--PIDI----ERLQSTNPKRPLSSANQNFNNSETLGHQGSHVVTLQLRIDGMHCMISQLEGVQQISVSLAEGTATVLYNPSVISPEELRAAIEDMGFEASVVSESCSTNPLGNHSAGNSMVQTTDGTPTSVQEVAPHTGRLPANHAPDILAKSPQSTRAVAPQKCFLQIKGMTCASCVSNIERNLQKEAGVLSVLVALMAGKAEIKYDPEVIQPLEIAQFIQDLGFEAAVMEDYAGSDGNIELTITGMTCASCVHNIESKLTRTNGITYASVALATSKALVKFDPEIIGPRDIIKIIEEIGFHASLAQRNPNAHHL-DH-KMEIKQWKKSFLCSLVFGIPVMALMI----------YMLIPSNEPHQSMVLDHNIIP----GLSILNLIFFILCTFVQLLGGWYFYVQAYKSLRHRSANMDVLIVLATSIAYVYSLVILVVAVAEKAERSPVTFFDTPPMLFVFIALGRWLEHLAKSKTSEALAKLMSLQATEATVVTLGEDNLIIREEQVPMELVQRGDIVKVVPGGKFPVDGKVLEGNTMADESLITGEAMPVTKKPGSTVIAGSINAHGSVLIKATHVGNDTTLAQIVKLVEEAQMSKAPIQQLADRFSGYFVPFIIIMSTLTLVVWIVIGFIDFGVVQRYFPNPNKHISQTEVIIRFAFQTSITVLCIACPCSLGLATPTAVMVGTGVAAQNGILIKGGKPLEMAHKIKTVMFDKTGTITHGVPRVMRVL-LLGDVATLPLRKVLAVVGTAEASSEHPLGVAVTKYCKEELGTETLGYCTDFQAVPGCGIGCK------------VSNVEGILAHSERP--LSAPASHLNEAGSLPAEKDAV-------------PQTFSVLIGNREWLRRNGLTISSDVSDAMTDHEMKGQTAILVAIDGVLCGMIAIADAVKQEAALAVHTLQSMGVDVVLITGDNRKTARAIATQVGINKVFAEVLPSHKVAKVQELQNKGK--------KVAMVGDGVNDSPALAQADMGVAIGTGTDVAIEAADVVLIRNDLLDVVASIHLSKRTVRRIRINLVLALIYNLVGIPIAAGVFMPIGIVLQPWMGSAAMAASSVSVVLSSLQLKCYKKPDLERY---EAQAHGHMKPLTASQVSVHIGMD 1296          

Query:  109 RMKVDGMTCMSCVRNIEENLMKFTGVCGIMVSLLHAEATVIFDADIATVEDISNKIDEMGFDVTVKSSEVSNVKDKVVRSRIKFESDINKSVEKSIETSLSSKLLLVRFCQENNYADIWHYSSIRSTEILSVIQQSEIYGVLVLEQCPTIRVIVRVNGMTCQSCVDNIESTVGKKQGIISIKVFLEKSEAHALVDASLAGP-DVEEMINDMGFNSEMILE------IFNDSCA--------GKPNNVSQ---KYEELKSNTIYPILSTT-------------IVIKALKSIFCIFKIENHMRALPGVDKCSVNLIEEIGMIDYDSGKWNVQKIREEIESLGYLTELPKQNWNSTRQSSAVSLNEESRSKCYLRITGMTCSSCVNKVESHLLKVEGVKSVLVALLAMKCEIIYDSAYVMPFQLSNRVKELGFNAEVIE 1326
            +++V+GMTC SCV +IE  + K  GV  + VSL + EA + +   +   ED+ + +++MGF+  +KS        KV    +    DI +    + +  LSS          NN   + H  S                 V+ L+        +R++GM C          + + +G+  I V L +  A  L + S+  P ++   I DMGF + ++ E      + N S          G P +V +       L +N    IL+ +             + IK +    C+  IE +++   GV    V L+     I YD       +I + I+ LG+             +++ +     S     L ITGMTC+SCV+ +ES L +  G+    VAL   K  + +D   + P  +   ++E+GF+A + +
Sbjct:  146 KLRVEGMTCQSCVSSIEGKVRKLQGVVRVKVSLSNQEAVITYQPYLIQPEDLRDHVNDMGFEAAIKS--------KVAPLSLG-PIDIERLQSTNPKRPLSSA-----NQNFNNSETLGHQGS----------------HVVTLQ--------LRIDGMHCM---------ISQLEGVQQISVSLAEGTATVLYNPSVISPEELRAAIEDMGFEASVVSESCSTNPLGNHSAGNSMVQTTDGTPTSVQEVAPHTGRLPANHAPDILAKSPQSTRAVAPQKCFLQIKGMTCASCVSNIERNLQKEAGVLSVLVALMAGKAEIKYDPEVIQPLEIAQFIQDLGF-------------EAAVMEDYAGSDGNIELTITGMTCASCVHNIESKLTRTNGITYASVALATSKALVKFDPEIIGPRDIIKIIEEIGFHASLAQ 522          

Query:  568 VRVNGMTCQSCVDNIESTVGKKQGIISIKVFLEKSEAHA-LVDASLAGPDVEEMINDMGFNSEMILEIFNDSCAGKPNNVSQKYEELKSNTIYPILSTTIVIKALKSIFCIFKIENHMRALPGVDKCSVNLIEEIGMIDYDSGKWNVQKIREEIESLGYLTEL---------------------PKQNWNSTRQ--SSAVSLNEESRS--KCYLRITGMTCSSCVNKVESHLLKVEGVKSVLVALLAMKCEIIYDSAYVMPFQLSNRVKELGFNAEVIEN-------GNEGIGIVNVLIR------------------------------------------------GMTCSSCVNHIENHISKIKGIASINVSLSTSKGKVEYFISECGPRDVIDAINDMGFDASLCDHLESNHAAAD 1584
            VR+ GMTCQSCV +IE  +   +GIIS+KV LE+  A    V + +    V   I DMGF +     I     A  P+      E +            + ++ +    C+  IE  +R L GV +  V+L  +  +I Y       + +R+ +  +G+   +                     PK+  +S  Q  +++ +L  +        LRI GM C          + ++EGV+ + V+L      ++Y+ + + P +L   ++++GF A V+         GN   G  N +++                                                GMTC+SCV++IE ++ K  G+ S+ V+L   K +++Y      P ++   I D+GF+A++ +    ++A +D
Sbjct:   62 VRILGMTCQSCVKSIEDRISNLKGIISMKVSLEQGSATVKYVPSVVCLQQVCHQIGDMGFEA----SIAEGKAASWPSRSLPAQEAV----------VKLRVEGMTCQSCVSSIEGKVRKLQGVVRVKVSLSNQEAVITYQPYLIQPEDLRDHVNDMGFEAAIKSKVAPLSLGPIDIERLQSTNPKRPLSSANQNFNNSETLGHQGSHVVTLQLRIDGMHC---------MISQLEGVQQISVSLAEGTATVLYNPSVISPEELRAAIEDMGFEASVVSESCSTNPLGNHSAG--NSMVQTTDGTPTSVQEVAPHTGRLPANHAPDILAKSPQSTRAVAPQKCFLQIKGMTCASCVSNIERNLQKEAGVLSVLVALMAGKAEIKYDPEVIQPLEIAQFIQDLGFEAAVME----DYAGSD 452          

Query:  109 RMKVDGMTCMSCVRNIEENLMKFTGVCGIMVSLLHAEATVIFDADIATVEDISNKIDEMGFDVTVKSSEVSNVKDKVVRSRIKFESDINKSVEKSIETSLSSKLLLVRFCQENNYADIWHYSSIRSTEILSVIQQSEIYGVLVLEQCPTIRVIVRVNGMTCQSCVDNIESTVGKKQGIISIKVFLEKSEAHALVDASLAGP-DVEEMINDMGFNSEMILEIFNDSCAGKPNNVSQKYEELKSNTIYPILSTTIVIKALKSIFCIFKIENHMRALPGVDKCSVNLIEEIGMIDYDSGKWNVQKIREEIESLGYLTELPKQNWNS 1074
            ++++DGM CM         + +  GV  I VSL    ATV+++  + + E++   I++MGF+ +V S   S        + +   S  N  V+ +  T  S + +              H   + +     ++ +S      V  Q    +  +++ GMTC SCV NIE  + K+ G++S+ V L   +A    D  +  P ++ + I D+GF + ++     +  AG   N+                   + I  +    C+  IE+ +    G+   SV L     ++ +D      + I + IE +G+   L ++N N+
Sbjct:  260 QLRIDGMHCM---------ISQLEGVQQISVSLAEGTATVLYNPSVISPEELRAAIEDMGFEASVVSESCST-------NPLGNHSAGNSMVQTTDGTPTSVQEVAP------------HTGRLPANHAPDILAKSPQSTRAVAPQ----KCFLQIKGMTCASCVSNIERNLQKEAGVLSVLVALMAGKAEIKYDPEVIQPLEIAQFIQDLGFEAAVM-----EDYAGSDGNIE------------------LTITGMTCASCVHNIESKLTRTNGITYASVALATSKALVKFDPEIIGPRDIIKIIEEIGFHASLAQRNPNA 527          

Query: 1294 KELGFNAEVIENGNEGIG------IVNVLIRGMTCSSCVNHIENHISKIKGIASINVSLSTSKGKVEYFISECGPRDVIDAINDMGFDASLCD 1554
            K   F+    E G +G+G         V I GMTC SCV  IE+ IS +KGI S+ VSL      V+Y  S    + V   I DMGF+AS+ +
Sbjct:   35 KSFAFDNVGYEGGLDGLGPSSQVATSTVRILGMTCQSCVKSIEDRISNLKGIISMKVSLEQGSATVKYVPSVVCLQQVCHQIGDMGFEASIAE 127          

Query:  100 GSARMKVDGMTCMSCVRNIEENLMKFTGVCGIMVSLLHAEATVIFDADIATVEDISNKIDEMGFDVTV 303
            G+  + + GMTC SCV NIE  L +  G+    V+L  ++A V FD +I    DI   I+E+GF  ++
Sbjct:  453 GNIELTITGMTCASCVHNIESKLTRTNGITYASVALATSKALVKFDPEIIGPRDIIKIIEEIGFHASL 520          

Query:  109 RMKVDGMTCMSCVRNIEENLMKFTGVCGIMVSLLHAEATVIFDADIATVEDISNKIDEMGFDVTVKSSEVSNVKDKVVRSRIKFESDINKSVEKSIETSLSSKLLLVRFCQENNYADIWHYSSIRSTEILSVIQQSEIYGVLVLEQCPTIRVIVRVNGMTCQSCVDNIESTVGKKQGIISIKVFLEKSEAHALVDASLAGP-DVEEMINDMGFNSEMILEIFNDSCAGKPNN----VSQKYEELKSNTIYPILSTTIV-IKALKSIFCIFKIENHMRALPGVDKCSVNLIEEIGMIDYDSGKWNVQKIREEIESLGY----------------------------------------LTELPKQNWNSTRQSSAVSLNEESRSKCYLRITGMTCSSCVNKVESHLLKVEGVKSVLVALLAMKCEIIYDSAYVMPFQLSNRVKELGFNAEVIENGNEGIGIVNVLIRGMTCSSCVNHIENHISKIKGIASINVSLSTSKGKVEYFISECGPRDVIDAINDMGFDASLCDHLESNHAAADHINQMIKQWRSSFFFSLICGIPXXXXXXXXXXXXXXXXHTIIHENGSNRTIM--KSTVPMVCSGLSADNLILFVLATPVQFYGARYFYIQAYLSLKHKTTNMDVLVVMATXXXXXXXXXXXXXXMAFRRNTSPKTFFETSPMLIVFLSLGRWLEHIAKGKTSEALTKLMSLQAVEATLYT--PEN---KERKIPINLVQRNDLIKILPGEKIPVDGKVVTGTSTCDESLITGESMPIEKTHGSDVIGGSINKSGMLIVKATHVGSDSALAQIVKLVEEAQTSKAPIQQLADRIAGMFVPSVLICAIITLIIWVIVGFSKPEILPKYV----NELSVTEITWEHAFQLAITVLSIACPCSLGLXXXXXXXXXXXXXXXNGILIKGGEPLENIHKLNVIVFDKTGTITNGSPSVTRFLVLIGNGVREHIDKLLKILAAAESASEHPIGKAIITFSKARISNENLPEVLESSAVSGCGLGCKLNLDPKTEVTKFVKNLINIESPSEETNILGQXXXXXXXXXXXXTYKDVIFPVRQHMAWTSDLCQTVTVIIGNRNWMLRNGILVDDEVDELMSEDENLGRTVILMAIDNELIAMISVADQVKREAALAVYTLKKMNIEVYLMTGDNSKTATAIARQVGIHYVFAEVLPSHKVAKVQQLQNTNRSLTSKRKMKVAMVGDGINDSPALAQSDVGIAIGTGTDVAVEAADVVLIRNSLLDVIAAIQLSKATVKRIRQNFIAATLYNLLGIPIAAGVLMPIGIEMMPWMXXXXXXXXXXXXXXXXXXXXXWKKPSEEKLITPEYINFIQSSGLSESQIIVRRGID 4008
            +++V+GMTC SCV +IE  + K  GV  + VSL + EA + +   +   ED+ + +++MGF+  +KS        KV    +    DI +    + +  LSS          NN   + H  S                 V+ L+        +R++GM C+SCV NIE  +G+  G+ SI+V LE   A    D S   P  ++  I  +   +  +     D   G   +     S        N +    STT++ I  +    C+  IE  +  L GV + SV+L E    + Y+    + +++R  IE +G+                                           LP  +       S  S    +  KC+L+I GMTC+SCV+ +E +L K  GV SVLVAL+A K EI YD   + P +++  +++LGF A V+E+     G + + I GMTC+SCV++IE+ +++  GI   +V+L+TSK  V++     GPRD+I  I ++GF ASL     + H   DH    IKQW+ SF  SL+ GIP M +M+          + +I  N  +++++   + +P    GLS  NLI F+L T          ++QA                                        SP TFF+T PML VF++LGRWLEH+AK KTSEAL KLMSLQA EAT+ T   +N   +E ++P+ LVQR D++K++PG K PVDGKV+ G +  DESLITGE+MP+ K  GS VI GSIN  G +++KATHVG+D+ LAQIVKLVEEAQ SKAPIQQLADR +G FVP ++I + +TL++W+++GF    ++ +Y       +S TE+    AFQ +ITVL IACPCSLGLATPTAVMVGTGV A NGILIKGG+PLE  HK+  ++FDKTGTIT+G P V R L L+G+     + K+L ++  AE++SEHP+G A+  + K  +  E L    +  AV GCG+GCK            V N+  I + SE    L    +           KD +              QT +V+IGNR W+ RNG+ +  +V + M++ E  G+T IL+AID  L  MI++AD VK+EAALAV+TL+ M ++V L+TGDN KTA AIA QVGI+ VFAEVLPSHKVAKVQ+LQN  +        KVAMVGDG+NDSPALAQ+D+G+AIGTGTDVA+EAADVVLIRN LLDV+A+I LSK TV+RIR N + A +YNL+GIPIAAGV MPIGI + PWM SAAMAASSVSVV  SL LK +KKP  E+    E         L+ SQ+ V  G+D
Sbjct:  146 KLRVEGMTCQSCVSSIEGKVRKLQGVVRVKVSLSNQEAVITYQPYLIQPEDLRDHVNDMGFEAAIKS--------KVAPLSLG-PIDIERLQSTNPKRPLSSA-----NQNFNNSETLGHQGS----------------HVVTLQ--------LRIDGMHCKSCVLNIEENIGQLLGVQSIQVSLENKTAQVKYDPSCTSPVALQRAIEALPPGNFKVS--LPDGAEGSGTDHRSSSSHSPGSPPRNQVQGTCSTTLIAIAGMTCASCVHSIEGMISQLEGVQQISVSLAEGTATVLYNPSVISPEELRAAIEDMGFEASVVSESCSTNPLGNHSAGNSMVQTTDGTPTSVQEVAPHTGRLPANHAPDILAKSPQSTRAVAPQKCFLQIKGMTCASCVSNIERNLQKEAGVLSVLVALMAGKAEIKYDPEVIQPLEIAQFIQDLGFEAAVMEDYAGSDGNIELTITGMTCASCVHNIESKLTRTNGITYASVALATSKALVKFDPEIIGPRDIIKIIEEIGFHASLAQRNPNAHHL-DH-KMEIKQWKKSFLCSLVFGIPVMALMI----------YMLIPSNEPHQSMVLDHNIIP----GLSILNLIFFILCT----------FVQA--------------------------------------ERSPVTFFDTPPMLFVFIALGRWLEHLAKSKTSEALAKLMSLQATEATVVTLGEDNLIIREEQVPMELVQRGDIVKVVPGGKFPVDGKVLEGNTMADESLITGEAMPVTKKPGSTVIAGSINAHGSVLIKATHVGNDTTLAQIVKLVEEAQMSKAPIQQLADRFSGYFVPFIIIMSTLTLVVWIVIGFIDFGVVQRYFPNPNKHISQTEVIIRFAFQTSITVLCIACPCSLGLATPTAVMVGTGVAAQNGILIKGGKPLEMAHKIKTVMFDKTGTITHGVPRVMRVL-LLGDVATLPLRKVLAVVGTAEASSEHPLGVAVTKYCKEELGTETLGYCTDFQAVPGCGIGCK------------VSNVEGILAHSERP--LSAPASHLNEAGSLPAEKDAV-------------PQTFSVLIGNREWLRRNGLTISSDVSDAMTDHEMKGQTAILVAIDGVLCGMIAIADAVKQEAALAVHTLQSMGVDVVLITGDNRKTARAIATQVGINKVFAEVLPSHKVAKVQELQNKGK--------KVAMVGDGVNDSPALAQADMGVAIGTGTDVAIEAADVVLIRNDLLDVVASIHLSKRTVRRIRINLVLALIYNLVGIPIAAGVFMPIGIVLQPWMGSAAMAASSVSVVLSSLQLKCYKKPDLERY---EAQAHGHMKPLTASQVSVHIGMD 1359          

Query:  568 VRVNGMTCQSCVDNIESTVGKKQGIISIKVFLEKSEAHA-LVDASLAGPDVEEMINDMGFNSEMILEIFNDSCAGKPNNVSQKYEELKSNTIYPILSTTIVIKALKSIFCIFKIENHMRALPGVDKCSVNLIEEIGMIDYDSGKWNVQKIREEIESLGYLTEL---------------------PKQNWNSTRQS--SAVSLNEESRS--KCYLRITGMTCSSCVNKVESHLLKVEGVKSVLVALLAMKCEIIYDSAYVMPFQLSNRVKEL--GFNAEVIENGNEGIGIVN------------------------VLIRGMTCSSCVNHIENHISKIKGIASINVSLSTSKGKVEYFISECGPRDVIDAINDMGFDASLCDHLESNHAAADH 1587
            VR+ GMTCQSCV +IE  +   +GIIS+KV LE+  A    V + +    V   I DMGF +     I     A  P+      E +            + ++ +    C+  IE  +R L GV +  V+L  +  +I Y       + +R+ +  +G+   +                     PK+  +S  Q+  ++ +L  +        LRI GM C SCV  +E ++ ++ GV+S+ V+L     ++ YD +   P  L   ++ L  G     + +G EG G  +                        + I GMTC+SCV+ IE  IS+++G+  I+VSL+     V Y  S   P ++  AI DMGF+AS+     S +   +H
Sbjct:   62 VRILGMTCQSCVKSIEDRISNLKGIISMKVSLEQGSATVKYVPSVVCLQQVCHQIGDMGFEAS----IAEGKAASWPSRSLPAQEAV----------VKLRVEGMTCQSCVSSIEGKVRKLQGVVRVKVSLSNQEAVITYQPYLIQPEDLRDHVNDMGFEAAIKSKVAPLSLGPIDIERLQSTNPKRPLSSANQNFNNSETLGHQGSHVVTLQLRIDGMHCKSCVLNIEENIGQLLGVQSIQVSLENKTAQVKYDPSCTSPVALQRAIEALPPGNFKVSLPDGAEGSGTDHRSSSSHSPGSPPRNQVQGTCSTTLIAIAGMTCASCVHSIEGMISQLEGVQQISVSLAEGTATVLYNPSVISPEELRAAIEDMGFEASVVSESCSTNPLGNH 439          

Query:  562 VIVRVNGMTCQSCVDNIESTVGKKQGIISIKVFLEKSEAHALVDASLAGP-DVEEMINDMGFNSEMI------------LEIFNDSCAGKP-NNVSQKY--EELKSNTIYPILSTTIVIKALKSIFCIFKIENHMRALPGVDKCSVNLIEEIGMIDYDSGKWNVQKIREEIESLGYLTELPKQNWNSTRQSSAVSLNEESR-------------------SKCYLRITGMTCSSCVNKVESHLLKVEGVKSVLVALLAMKCEIIYDSAYVMPFQLSNRVKELGFNAEVIEN-------GNEGIGIVNVLIR------------------------------------------------GMTCSSCVNHIENHISKIKGIASINVSLSTSKGKVEYFISECGPRDVIDAINDMGFDASLCDHLESNHAAAD 1584
            V +RV GMTCQSCV +IE  V K QG++ +KV L   EA       L  P D+ + +NDMGF + +             +E    +   +P ++ +Q +   E   +    +++  + I  +    C+  IE ++  L GV    V+L  +   + YD    +   ++  IE+      LP  N+  +    A     + R                   S   + I GMTC+SCV+ +E  + ++EGV+ + V+L      ++Y+ + + P +L   ++++GF A V+         GN   G  N +++                                                GMTC+SCV++IE ++ K  G+ S+ V+L   K +++Y      P ++   I D+GF+A++ +    ++A +D
Sbjct:  145 VKLRVEGMTCQSCVSSIEGKVRKLQGVVRVKVSLSNQEAVITYQPYLIQPEDLRDHVNDMGFEAAIKSKVAPLSLGPIDIERLQSTNPKRPLSSANQNFNNSETLGHQGSHVVTLQLRIDGMHCKSCVLNIEENIGQLLGVQSIQVSLENKTAQVKYDPSCTSPVALQRAIEA------LPPGNFKVSLPDGAEGSGTDHRSSSSHSPGSPPRNQVQGTCSTTLIAIAGMTCASCVHSIEGMISQLEGVQQISVSLAEGTATVLYNPSVISPEELRAAIEDMGFEASVVSESCSTNPLGNHSAG--NSMVQTTDGTPTSVQEVAPHTGRLPANHAPDILAKSPQSTRAVAPQKCFLQIKGMTCASCVSNIERNLQKEAGVLSVLVALMAGKAEIKYDPEVIQPLEIAQFIQDLGFEAAVME----DYAGSD 563          

Query:  100 GSARMKVDGMTCMSCVRNIEENLMKFTGVCGIMVSLLHAEATVIFDADIATVEDISNKIDEMGFDVTV 303
            G+  + + GMTC SCV NIE  L +  G+    V+L  ++A V FD +I    DI   I+E+GF  ++
Sbjct:  564 GNIELTITGMTCASCVHNIESKLTRTNGITYASVALATSKALVKFDPEIIGPRDIIKIIEEIGFHASL 631          

Query: 1813 VQFYGARYFYIQAYLSLKHKTTNMDVLVVMATXXXXXXXXXXXXXXMAFRRNTSPKTFFETSPMLIVFLSLGRWLEHIAKGKTSEALTKLMSLQAVEATLYT--PEN---KERKIPINLVQRNDLIKILPGEKIPVDGKVVTGTSTCDESLITGESMPIEKTHGSDVIGGSINKSGMLIVKATHVGSDSALAQIVKLVEEAQTSKAPIQQLADRIAGMFVPSVLICAIITLIIWVIVGFSKPEILPKYV----NELSVTEITWEHAFQLAITVLSIACPCSLGLXXXXXXXXXXXXXXXNGILIKGGEPLENIHKLNVIVFDKTGTITNGSPSVTRFLVLIGNGVREHIDKLLKILAAAESASEHPIGKAIITFSKARISNENLPEVLESSAVSGCGLGCKLNLDPKTEVTKFVKNLINIESPSEETNILGQXXXXXXXXXXXXTYKDVIFPVRQHMAWTSDLCQTVTVIIGNRNWMLRNGILVDDEVDELMSEDENLGRTVILMAIDNELIAMISVADQVKREAALAVYTLKKMNIEVYLMTGDNSKTATAIARQVGIHYVFAEVLPSHKVAKVQQLQNTNRSLTSKRKMKVAMVGDGINDSPALAQSDVGIAIGTGTDVAVEAADVVLIRNSLLDVIAAIQLSKATVKRIRQNFIAATLYNLLGIPIAAGVLMPIGIEMMPWMXXXXXXXXXXXXXXXXXXXXXWKKPSEEKLITPEYINFIQSSGLSESQIIVRRGID 4008
            ++  G  YFY+QAY SL+H++ NMDVL+V+ATSI+Y+YS++++V+++A +   SP TFF+T PML VF++LGRWLEH+AK KTSEAL KLMSLQA EAT+ T   +N   +E ++P+ LVQR D++K++PG K PVDGKV+ G +  DESLITGE+MP+ K  GS VI GSIN  G +++KATHVG+D+ LAQIVKLVEEAQ SKAPIQQLADR +G FVP ++I + +TL++W+++GF    ++ +Y       +S TE+    AFQ +ITVL IACPCSLGLATPTAVMVGTGV A NGILIKGG+PLE  HK+  ++FDKTGTIT+G P V R L L+G+     + K+L ++  AE++SEHP+G A+  + K  +  E L    +  AV GCG+GCK            V N+  I + SE    L    +           KD +              QT +V+IGNR W+ RNG+ +  +V + M++ E  G+T IL+AID  L  MI++AD VK+EAALAV+TL+ M ++V L+TGDN KTA AIA QVGI+ VFAEVLPSHKVAKVQ+LQN  +        KVAMVGDG+NDSPALAQ+D+G+AIGTGTDVA+EAADVVLIRN LLDV+A+I LSK TV+RIR N + A +YNL+GIPIAAGV MPIGI + PWM SAAMAASSVSVV  SL LK +KKP  E+    E         L+ SQ+ V  G+D
Sbjct:  622 IELLGGWYFYVQAYKSLRHRSANMDVLIVLATSIAYVYSLVILVVAVAEKAERSPVTFFDTPPMLFVFIALGRWLEHLAKSKTSEALAKLMSLQATEATVVTLGEDNLIIREEQVPMELVQRGDIVKVVPGGKFPVDGKVLEGNTMADESLITGEAMPVTKKPGSTVIAGSINAHGSVLIKATHVGNDTTLAQIVKLVEEAQMSKAPIQQLADRFSGYFVPFIIIMSTLTLVVWIVIGFIDFGVVQRYFPNPNKHISQTEVIIRFAFQTSITVLCIACPCSLGLATPTAVMVGTGVAAQNGILIKGGKPLEMAHKIKTVMFDKTGTITHGVPRVMRVL-LLGDVATLPLRKVLAVVGTAEASSEHPLGVAVTKYCKEELGTETLGYCTDFQAVPGCGIGCK------------VSNVEGILAHSERP--LSAPASHLNEAGSLPAEKDAV-------------PQTFSVLIGNREWLRRNGLTISSDVSDAMTDHEMKGQTAILVAIDGVLCGMIAIADAVKQEAALAVHTLQSMGVDVVLITGDNRKTARAIATQVGINKVFAEVLPSHKVAKVQELQNKGK--------KVAMVGDGVNDSPALAQADMGVAIGTGTDVAIEAADVVLIRNDLLDVVASIHLSKRTVRRIRINLVLALIYNLVGIPIAAGVFMPIGIVLQPWMGSAAMAASSVSVVLSSLQLKCYKKPDLERY---EAQAHGHMKPLTASQVSVHIGMD 1323          

Query:  109 RMKVDGMTCMSCVRNIEENLMKFTGVCGIMVSLLHAEATVIFDADIATVEDISNKIDEMGFDVTVKSSEVSNVKDKVVRSRIKFESDINKSVEKSIETSLSSKLLLVRFCQENNYADIWHYSSIRSTEILSVIQQSEIYGVLVLEQCPTIRVIVRVNGMTCQSCVDNIESTVGKKQGIISIKVFLEKSEAHALVDASLAGP-DVEEMINDMGFNSEMILEIFNDSCAGKPNN----VSQKYEELKSNTIYPILSTTIV-IKALKSIFCIFKIENHMRALPGVDKCSVNLIEEIGMIDYDSGKWNVQKIREEIESLGY----------------------------------------LTELPKQNWNSTRQSSAVSLNEESRSKCYLRITGMTCSSCVNKVESHLLKVEGVKSVLVALLAMKCEIIYDSAYVMPFQLSNRVKELGFNAEVIENGNEGIGIVNVLIRGMTCSSCVNHIENHISKIKGIASINVSLSTSKGKVEYFISECGPRDVIDAINDMG 1533
            +++V+GMTC SCV +IE  + K  GV  + VSL + EA + +   +   ED+ + +++MGF+  +KS +V+ +    +        DI +    + +  LSS          NN   + H  S                 V+ L+        +R++GM C+SCV NIE  +G+  G+ SI+V LE   A    D S   P  ++  I  +   +  +     D   G   +     S        N +    STT++ I  +    C+  IE  +  L GV + SV+L E    + Y+    + +++R  IE +G+                                           LP  +       S  S    +  KC+L+I GMTC+SCV+ +E +L K  GV SVLVAL+A K EI YD   + P +++  +++LGF A V+E+     G + + I GMTC+SCV++IE+ +++  GI   +V+L+TSK  V++     GPRD+I  I  +G
Sbjct:  146 KLRVEGMTCQSCVSSIEGKVRKLQGVVRVKVSLSNQEAVITYQPYLIQPEDLRDHVNDMGFEAAIKS-KVAPLSLGPI--------DIERLQSTNPKRPLSSA-----NQNFNNSETLGHQGS----------------HVVTLQ--------LRIDGMHCKSCVLNIEENIGQLLGVQSIQVSLENKTAQVKYDPSCTSPVALQRAIEALPPGNFKVS--LPDGAEGSGTDHRSSSSHSPGSPPRNQVQGTCSTTLIAIAGMTCASCVHSIEGMISQLEGVQQISVSLAEGTATVLYNPSVISPEELRAAIEDMGFEASVVSESCSTNPLGNHSAGNSMVQTTDGTPTSVQEVAPHTGRLPANHAPDILAKSPQSTRAVAPQKCFLQIKGMTCASCVSNIERNLQKEAGVLSVLVALMAGKAEIKYDPEVIQPLEIAQFIQDLGFEAAVMEDYAGSDGNIELTITGMTCASCVHNIESKLTRTNGITYASVALATSKALVKFDPEIIGPRDIIKIIELLG 626          

Query:  568 VRVNGMTCQSCVDNIESTVGKKQGIISIKVFLEKSEAHA-LVDASLAGPDVEEMINDMGFNSEMILEIFNDSCAGKPNNVSQKYEELKSNTIYPILSTTIVIKALKSIFCIFKIENHMRALPGVDKCSVNLIEEIGMIDYDSGKWNVQKIREEIESLGYLTEL---------------------PKQNWNSTRQS--SAVSLNEESRS--KCYLRITGMTCSSCVNKVESHLLKVEGVKSVLVALLAMKCEIIYDSAYVMPFQLSNRVKEL--GFNAEVIENGNEGIGIVN------------------------VLIRGMTCSSCVNHIENHISKIKGIASINVSLSTSKGKVEYFISECGPRDVIDAINDMGFDASLCDHLESNHAAADH 1587
            VR+ GMTCQSCV +IE  +   +GIIS+KV LE+  A    V + +    V   I DMGF +     I     A  P+      E +            + ++ +    C+  IE  +R L GV +  V+L  +  +I Y       + +R+ +  +G+   +                     PK+  +S  Q+  ++ +L  +        LRI GM C SCV  +E ++ ++ GV+S+ V+L     ++ YD +   P  L   ++ L  G     + +G EG G  +                        + I GMTC+SCV+ IE  IS+++G+  I+VSL+     V Y  S   P ++  AI DMGF+AS+     S +   +H
Sbjct:   62 VRILGMTCQSCVKSIEDRISNLKGIISMKVSLEQGSATVKYVPSVVCLQQVCHQIGDMGFEAS----IAEGKAASWPSRSLPAQEAV----------VKLRVEGMTCQSCVSSIEGKVRKLQGVVRVKVSLSNQEAVITYQPYLIQPEDLRDHVNDMGFEAAIKSKVAPLSLGPIDIERLQSTNPKRPLSSANQNFNNSETLGHQGSHVVTLQLRIDGMHCKSCVLNIEENIGQLLGVQSIQVSLENKTAQVKYDPSCTSPVALQRAIEALPPGNFKVSLPDGAEGSGTDHRSSSSHSPGSPPRNQVQGTCSTTLIAIAGMTCASCVHSIEGMISQLEGVQQISVSLAEGTATVLYNPSVISPEELRAAIEDMGFEASVVSESCSTNPLGNH 439          

Query:  562 VIVRVNGMTCQSCVDNIESTVGKKQGIISIKVFLEKSEAHALVDASLAGP-DVEEMINDMGFNSEMI------------LEIFNDSCAGKP-NNVSQKY--EELKSNTIYPILSTTIVIKALKSIFCIFKIENHMRALPGVDKCSVNLIEEIGMIDYDSGKWNVQKIREEIESLGYLTELPKQNWNSTRQSSAVSLNEESR-------------------SKCYLRITGMTCSSCVNKVESHLLKVEGVKSVLVALLAMKCEIIYDSAYVMPFQLSNRVKELGFNAEVIEN-------GNEGIGIVNVLIR------------------------------------------------GMTCSSCVNHIENHISKIKGIASINVSLSTSKGKVEYFISECGPRDVIDAINDMGFDASLCDHLESNHAAAD 1584
            V +RV GMTCQSCV +IE  V K QG++ +KV L   EA       L  P D+ + +NDMGF + +             +E    +   +P ++ +Q +   E   +    +++  + I  +    C+  IE ++  L GV    V+L  +   + YD    +   ++  IE+      LP  N+  +    A     + R                   S   + I GMTC+SCV+ +E  + ++EGV+ + V+L      ++Y+ + + P +L   ++++GF A V+         GN   G  N +++                                                GMTC+SCV++IE ++ K  G+ S+ V+L   K +++Y      P ++   I D+GF+A++ +    ++A +D
Sbjct:  145 VKLRVEGMTCQSCVSSIEGKVRKLQGVVRVKVSLSNQEAVITYQPYLIQPEDLRDHVNDMGFEAAIKSKVAPLSLGPIDIERLQSTNPKRPLSSANQNFNNSETLGHQGSHVVTLQLRIDGMHCKSCVLNIEENIGQLLGVQSIQVSLENKTAQVKYDPSCTSPVALQRAIEA------LPPGNFKVSLPDGAEGSGTDHRSSSSHSPGSPPRNQVQGTCSTTLIAIAGMTCASCVHSIEGMISQLEGVQQISVSLAEGTATVLYNPSVISPEELRAAIEDMGFEASVVSESCSTNPLGNHSAG--NSMVQTTDGTPTSVQEVAPHTGRLPANHAPDILAKSPQSTRAVAPQKCFLQIKGMTCASCVSNIERNLQKEAGVLSVLVALMAGKAEIKYDPEVIQPLEIAQFIQDLGFEAAVME----DYAGSD 563          

Query:  565 IVRVNGMTCQSCVDNIESTVGKKQGIISIKVFLEKSEAHALVDAS-LAGPDVEEMINDMGFNSEMILEIFNDSCAGKPNNVSQKYEELKSNTIYPILSTTIVIKALKSIFCIFKIENHMRALPGVDKCSVNLIEEIGMIDYDSGKWNVQKIREEIESLGY---------LTELPKQNWNSTR------------------QSSAVSLNEESRS----KCYLRITGMTCSSCVNKVESHLLKVEGVKSVLVALLAMKCEIIYDSAYVMPFQLSNRVK-ELGFNAEVIEN--GNEGIGIVNVLIRGMTCSSCVNHIENHISKIKGIASINVSLSTSKGKVEYFISECGPRDVIDAINDMGFDASLCDHLESNHAAADHINQMIKQWRSSFFFSLICGIPXXXXXXXXXXXXXXXXHTIIHENGSNRTIMK--STVPMVCSGLSADNLILFVLATPVQFYGARYFYIQAYLSLKHKTTNMDVLVVMATXXXXXXXXXXXXXXMAFRRNTSPKTFFETSPMLIVFLSLGRWLEHIAKGKTSEALTKLMSLQAVEATLYTPENK-----ERKIPINLVQRNDLIKILPGEKIPVDGKVVTGTSTCDESLITGESMPIEKTHGSDVIGGSINKSGMLIVKATHVGSDSALAQIVKLVEEAQTSKAPIQQLADRIAGMFVPSVLICAIITLIIWVIVGF--SKPEILPKYVNELSVTEITWEHAFQLAITVLSIACPCSLGLXXXXXXXXXXXXXXXNGILIKGGEPLENIHKLNVIVFDKTGTITNGSPSVTRFLVLIGNGVREHIDKLLKILAAA-ESASEHPIGKAIITFSKARISNENLPEVLESSAVSGCGLGCKLN----------LDPKTEVTKFVKNLINIESPSEETNILGQXXXXXXXXXXXXTYKDVIFPVRQHMAWTSDLCQTVTVIIGNRNWMLRNGILVDDEVDELMSEDENLGRTVILMAIDNELIAMISVADQVKREAALAVYTLKKMNIEVYLMTGDNSKTATAIARQVGIHYVFAEVLPSHKVAKVQQLQNTNRSLTSKRKMKVAMVGDGINDSPALAQSDVGIAIGTGTDVAVEAADVVLIRNSLLDVIAAIQLSKATVKRIRQNFIAATLYNLLGIPIAAGVLMPIGIEMMPWMXXXXXXXXXXXXXXXXXXXXXWKKPSEEKLITPEY---INFIQSSGLSESQIIVRRGID 4008
            ++ + GMTC SCV NI+  +G K GI SI+V L++  A    D +      V E ++DMGF+ +++ +      A KP                 I    + I+ +    C+  I++ + +  G+ K  V+L ++ G +DY+S KWN + + E I+ +G+         +  +  Q  ++T+                  Q + V  ++E  S    KC   + GMTC+SCV  +E ++ K+EGV S++VAL+A K E+IYD        +   +  ELG+ A ++++   N     + ++I  ++  S  N IE+H+    GI S NVS++TS   VE+     GPRD+I+ +  +GF A L    +      DH +  +K+WR++FF +LI G+P M +M+          H I+      RT M      P+    LS DN +L  L TPVQ +G RYFY+ ++ ++KH   NMDVL++++T+I+Y YS++V+++++ F+  +SP TFF+  PMLIVF++LGR LEH AKGKTSEAL+KLMSLQA EATL T +++     E+ I I LVQRNDLIK++PG K+PVDG VV G S+ DES ITGESMP+ K  GS VIGGS+N+ G+LIVKATHVG+DS L+QIV+LVEEAQT++APIQQLAD+IAG FVP V++ ++ TL +W+ + +  ++   LP  +      +I    AF+ AITVL+IACPCSLGLATPTAVMVGTGVGA NGILIKGGEPLE++HK+  IVFDKTGTIT G P V +    +         KL+  L+ A E+ SEHPIG A+  F+K  ++    P        +G G+ C+++          L   T     + +   I  P  E N+L            +++ K+V  P             T  ++IG    M R+GI V + V   +SE++  G   ++ AI+ E++A+IS+ADQVK+EA+LA+YTL++M + V L+TGDNSKTA + A+QVGI  VFAEVLP+ K  K++QL+          K KVAMVGDG+NDSPALA+++VGIAI  G+DVA+E+A +VL+RN L+DV+ AI+LSK T +RIR NF+ A +YN +GIPIAAGV  P G  + PWMA+AAMA SSVSVV+ SLLLK ++KP+   L T  +     F++S      Q+ V RG+D
Sbjct:   50 MLEIKGMTCNSCVKNIQDVIGAKPGIHSIQVNLKEENAKCSFDTTKWTAEKVAEAVDDMGFDCKVLKKEPPTQMAEKPK----------------IRRAIVSIEGMTCHACVNNIQDTVGSKDGIVKIVVSLEQKQGTVDYNSEKWNGESVAESIDDMGFDCKLITDQEIAAVEPQKASTTKLSISPLKTVDLSDGKVELQLNGVKYSKEGSSDHLEKCTFAVEGMTCASCVQYIERNISKIEGVHSIVVALIAAKAEVIYDGRVTSSDAIREHMTGELGYKATLLDSMGANPNYSKIRLIIGNLSTESDANRIESHVLSKSGIDSCNVSIATSMALVEFSPQVIGPRDIINVVESLGFTADLATR-DDQMKRLDHSDD-VKKWRNTFFIALIFGVPVMIIMIIF--------HWIL------RTPMHPDKQTPIFTPALSLDNFLLLCLCTPVQIFGGRYFYVASWKAIKHGNANMDVLIMLSTTIAYTYSIVVLLLAIIFKWPSSPMTFFDVPPMLIVFIALGRMLEHKAKGKTSEALSKLMSLQAKEATLVTMDSEGRLTSEKGINIELVQRNDLIKVVPGAKVPVDGVVVDGKSSVDESFITGESMPVVKKPGSTVIGGSVNQKGVLIVKATHVGNDSTLSQIVRLVEEAQTNRAPIQQLADKIAGYFVPFVIVLSLFTLGVWIYIEYNSARNANLPPGLRFEEALKI----AFEAAITVLAIACPCSLGLATPTAVMVGTGVGAANGILIKGGEPLESVHKVTTIVFDKTGTITEGRPRVVQIASFVNPSTMSL--KLITFLSGATEALSEHPIGNAVAAFAKQLLNEPTWPNTSRFHVSAGHGVTCRIDSIRQSFSSLALSGSTCEIPRLPDGQTITIPGTEVNLL------------QVSSKEVSQPNP----------DTANIVIGTERMMERHGIPVSEVVKMTLSEEQRKGHISVICAINAEVVAVISIADQVKKEASLAIYTLREMGLRVVLLTGDNSKTAESTAKQVGIDEVFAEVLPNQKQQKIKQLKG--------YKNKVAMVGDGVNDSPALAEANVGIAIAAGSDVAIESAGIVLVRNDLVDVVGAIKLSKMTTRRIRLNFLFAIIYNAIGIPIAAGVFRPFGFMLQPWMAAAAMALSSVSVVSSSLLLKNFRKPTIANLYTTSFKRHQKFLESGSF---QVQVHRGLD 1184          

Query:   79 LAIRMKLGSARMKVDGMTCMSCVRNIEENLMKFTGVCGIMVSLLHAEATVIFDADIATVEDISNKIDEMGFDVT-VKSSEVSNVKDKVVRSRIKFESDINKSVEKSIETSLSSKLLLVRFCQENNYADIWHYSSIRSTEILSVIQQSEIYGVLVLEQCPTIRVIVRVNGMTCQSCVDNIESTVGKKQGIISIKVFLEKSEAHALVDASLAGPDV--EEMINDMGFNSEMILEIFNDSCAGKPNNVSQKYEELKSNTIYPILSTTIVIKALKSIFCIFKIENHMRALPGVDKCSVNLIEEIGMIDYDSGKWNVQKIREEIESLGYLTELPKQN 1065
            +A + K+  A + ++GMTC +CV NI++ +    G+  I+VSL   + TV ++++    E ++  ID+MGFD   +   E++ V+ +   S  K      K+V+ S +  +  +L  V++ +E +                             LE+C        V GMTC SCV  IE  + K +G+ SI V L  ++A  + D  +   D   E M  ++G+ + ++     DS    PN     Y +++           ++I  L +     +IE+H+ +  G+D C+V++   + ++++       + I   +ESLG+  +L  ++
Sbjct:  123 MAEKPKIRRAIVSIEGMTCHACVNNIQDTVGSKDGIVKIVVSLEQKQGTVDYNSEKWNGESVAESIDDMGFDCKLITDQEIAAVEPQKA-STTKLSISPLKTVDLS-DGKVELQLNGVKYSKEGSSDH--------------------------LEKC-----TFAVEGMTCASCVQYIERNISKIEGVHSIVVALIAAKAEVIYDGRVTSSDAIREHMTGELGYKATLL-----DSMGANPN-----YSKIR-----------LIIGNLSTESDANRIESHVLSKSGIDSCNVSIATSMALVEFSPQVIGPRDIINVVESLGFTADLATRD 400          

Query:  856 TTIVIKALKSIFCIFKIENHMRALPGVDKCSVNLIEEIGMIDYDSGKWNVQKIREEIESLGYLTELPKQNWNSTRQSSAVSLNEESR-SKCYLRITGMTCSSCVNKVESHLLKVEGVKSVLVALLAMKCEIIYDSAYVMPFQLSNRVKELGFNAEVI--------------------------------------------ENGNEGIGIVNVLIRGMTCSSCVNHIENHISKIKGIASINVSLSTSKGKVEYFISECGPRDVIDAI-----NDMGFDASLCDHLESN 1569
            T + IK +    C+  I++ + A PG+    VNL EE     +D+ KW  +K+ E ++ +G+       +    ++     + E+ +  +  + I GMTC +CVN ++  +   +G+  ++V+L   +  + Y+S       ++  + ++GF+ ++I                                            E  ++ +      + GMTC+SCV +IE +ISKI+G+ SI V+L  +K +V Y     G     DAI      ++G+ A+L D + +N
Sbjct:   49 TMLEIKGMTCNSCVKNIQDVIGAKPGIHSIQVNLKEENAKCSFDTTKWTAEKVAEAVDDMGF-------DCKVLKKEPPTQMAEKPKIRRAIVSIEGMTCHACVNNIQDTVGSKDGIVKIVVSLEQKQGTVDYNSEKWNGESVAESIDDMGFDCKLITDQEIAAVEPQKASTTKLSISPLKTVDLSDGKVELQLNGVKYSKEGSSDHLEKCTFAVEGMTCASCVQYIERNISKIEGVHSIVVALIAAKAEVIY----DGRVTSSDAIREHMTGELGYKATLLDSMGAN 325          

Query:  892 CIFKIENHMRALPGVDKCSVNLIEEIGMIDYDSGKWNVQKIREEIESLGY---------LTELPKQNWNSTR------------------QSSAVSLNEESRS----KCYLRITGMTCSSCVNKVESHLLKVEGVKSVLVALLAMKCEIIYDSAYVMPFQLSNRVK-ELGFNAEVIEN--GNEGIGIVNVLIRGMTCSSCVNHIENHISKIKGIASINVSLSTSKGKVEYFISECGPRDVIDAINDMGFDASLCDHLESNHAAADHINQMIKQWRSSFFFSLICGIPXXXXXXXXXXXXXXXXHTIIHENGSNRTIMK--STVPMVCSGLSADNLILFVLATPVQFYGARYFYIQAYLSLKHKTTNMDVLVVMATXXXXXXXXXXXXXXMAFRRNTSPKTFFETSPMLIVFLSLGRWLEHIAKGKTSEALTKLMSLQAVEATLYTPENK-----ERKIPINLVQRNDLIKILPGEKIPVDGKVVTGTSTCDESLITGESMPIEKTHGSDVIGGSINKSGMLIVKATHVGSDSALAQIVKLVEEAQTSKAPIQQLADRIAGMFVPSVLICAIITLIIWVIVGF--SKPEILPKYVNELSVTEITWEHAFQLAITVLSIACPCSLGLXXXXXXXXXXXXXXXNGILIKGGEPLENIHKLNVIVFDKTGTITNGSPSVTRFLVLIGNGVREHIDKLLKILAAA-ESASEHPIGKAIITFSKARISNENLPEVLESSAVSGCGLGCKLN----------LDPKTEVTKFVKNLINIESPSEETNILGQXXXXXXXXXXXXTYKDVIFPVRQHMAWTSDLCQTVTVIIGNRNWMLRNGILVDDEVDELMSEDENLGRTVILMAIDNELIAMISVADQVKREAALAVYTLKKMNIEVYLMTGDNSKTATAIARQVGIHYVFAEVLPSHKVAKVQQLQNTNRSLTSKRKMKVAMVGDGINDSPALAQSDVGIAIGTGTDVAVEAADVVLIRNSLLDVIAAIQLSKATVKRIRQNFIAATLYNLLGIPIAAGVLMPIGIEMMPWMXXXXXXXXXXXXXXXXXXXXXWKKPSEEKLITPEY---INFIQSSGLSESQIIVRRGID 4008
            C+  I++ + +  G+ K  V+L ++ G +DY+S KWN + + E I+ +G+         +  +  Q  ++T+                  Q + V  ++E  S    KC   + GMTC+SCV  +E ++ K+EGV S++VAL+A K E+IYD        +   +  ELG+ A ++++   N     + ++I  ++  S  N IE+H+    GI S NVS++TS   VE+     GPRD+I+ +  +GF A L    +      DH +  +K+WR++FF +LI G+P M +M+          H I+      RT M      P+    LS DN +L  L TPVQ +G RYFY+ ++ ++KH   NMDVL++++T+I+Y YS++V+++++ F+  +SP TFF+  PMLIVF++LGR LEH AKGKTSEAL+KLMSLQA EATL T +++     E+ I I LVQRNDLIK++PG K+PVDG VV G S+ DES ITGESMP+ K  GS VIGGS+N+ G+LIVKATHVG+DS L+QIV+LVEEAQT++APIQQLAD+IAG FVP V++ ++ TL +W+ + +  ++   LP  +      +I    AF+ AITVL+IACPCSLGLATPTAVMVGTGVGA NGILIKGGEPLE++HK+  IVFDKTGTIT G P V +    +         KL+  L+ A E+ SEHPIG A+  F+K  ++    P        +G G+ C+++          L   T     + +   I  P  E N+L            +++ K+V  P             T  ++IG    M R+GI V + V   +SE++  G   ++ AI+ E++A+IS+ADQVK+EA+LA+YTL++M + V L+TGDNSKTA + A+QVGI  VFAEVLP+ K  K++QL+          K KVAMVGDG+NDSPALA+++VGIAI  G+DVA+E+A +VL+RN L+DV+ AI+LSK T +RIR NF+ A +YN +GIPIAAGV  P G  + PWMA+AAMA SSVSVV+ SLLLK ++KP+   L T  +     F++S      Q+ V RG+D
Sbjct:   22 CVNNIQDTVGSKDGIVKIVVSLEQKQGTVDYNSEKWNGESVAESIDDMGFDCKLITDQEIAAVEPQKASTTKLSISPLKTVDLSDGKVELQLNGVKYSKEGSSDHLEKCTFAVEGMTCASCVQYIERNISKIEGVHSIVVALIAAKAEVIYDGRVTSSDAIREHMTGELGYKATLLDSMGANPNYSKIRLIIGNLSTESDANRIESHVLSKSGIDSCNVSIATSMALVEFSPQVIGPRDIINVVESLGFTADLATR-DDQMKRLDHSDD-VKKWRNTFFIALIFGVPVMIIMIIF--------HWIL------RTPMHPDKQTPIFTPALSLDNFLLLCLCTPVQIFGGRYFYVASWKAIKHGNANMDVLIMLSTTIAYTYSIVVLLLAIIFKWPSSPMTFFDVPPMLIVFIALGRMLEHKAKGKTSEALSKLMSLQAKEATLVTMDSEGRLTSEKGINIELVQRNDLIKVVPGAKVPVDGVVVDGKSSVDESFITGESMPVVKKPGSTVIGGSVNQKGVLIVKATHVGNDSTLSQIVRLVEEAQTNRAPIQQLADKIAGYFVPFVIVLSLFTLGVWIYIEYNSARNANLPPGLRFEEALKI----AFEAAITVLAIACPCSLGLATPTAVMVGTGVGAANGILIKGGEPLESVHKVTTIVFDKTGTITEGRPRVVQIASFVNPSTMSL--KLITFLSGATEALSEHPIGNAVAAFAKQLLNEPTWPNTSRFHVSAGHGVTCRIDSIRQSFSSLALSGSTCEIPRLPDGQTITIPGTEVNLL------------QVSSKEVSQPNP----------DTANIVIGTERMMERHGIPVSEVVKMTLSEEQRKGHISVICAINAEVVAVISIADQVKKEASLAIYTLREMGLRVVLLTGDNSKTAESTAKQVGIDEVFAEVLPNQKQQKIKQLKG--------YKNKVAMVGDGVNDSPALAEANVGIAIAAGSDVAIESAGIVLVRNDLVDVVGAIKLSKMTTRRIRLNFLFAIIYNAIGIPIAAGVFRPFGFMLQPWMAAAAMALSSVSVVSSSLLLKNFRKPTIANLYTTSFKRHQKFLESGSF---QVQVHRGLD 1062          

Query:   79 LAIRMKLGSARMKVDGMTCMSCVRNIEENLMKFTGVCGIMVSLLHAEATVIFDADIATVEDISNKIDEMGFDVT-VKSSEVSNVKDKVVRSRIKFESDINKSVEKSIETSLSSKLLLVRFCQENNYADIWHYSSIRSTEILSVIQQSEIYGVLVLEQCPTIRVIVRVNGMTCQSCVDNIESTVGKKQGIISIKVFLEKSEAHALVDASLAGPDV--EEMINDMGFNSEMILEIFNDSCAGKPNNVSQKYEELKSNTIYPILSTTIVIKALKSIFCIFKIENHMRALPGVDKCSVNLIEEIGMIDYDSGKWNVQKIREEIESLGYLTELPKQN 1065
            +A + K+  A + ++GMTC +CV NI++ +    G+  I+VSL   + TV ++++    E ++  ID+MGFD   +   E++ V+ +   S  K      K+V+ S +  +  +L  V++ +E +                             LE+C        V GMTC SCV  IE  + K +G+ SI V L  ++A  + D  +   D   E M  ++G+ + ++     DS    PN     Y +++           ++I  L +     +IE+H+ +  G+D C+V++   + ++++       + I   +ESLG+  +L  ++
Sbjct:    1 MAEKPKIRRAIVSIEGMTCHACVNNIQDTVGSKDGIVKIVVSLEQKQGTVDYNSEKWNGESVAESIDDMGFDCKLITDQEIAAVEPQKA-STTKLSISPLKTVDLS-DGKVELQLNGVKYSKEGSSDH--------------------------LEKC-----TFAVEGMTCASCVQYIERNISKIEGVHSIVVALIAAKAEVIYDGRVTSSDAIREHMTGELGYKATLL-----DSMGANPN-----YSKIR-----------LIIGNLSTESDANRIESHVLSKSGIDSCNVSIATSMALVEFSPQVIGPRDIINVVESLGFTADLATRD 278          

Query:  559 RVIVRVNGMTCQSCVDNIESTVGKKQGIISIKVFLEKSEAHALVDA-SLAGPDVEEMINDMGFNSEMILEIFNDSCAGKPN---------------NVSQKYEELKSNTIY--------PILSTTIVIKALKSIFCIFKIENHMRALPGVDKCSVNLIEEIGMIDYDSGKWNVQKIREEIES-LGYLTELPKQNWNSTRQSSAVSLNEESRSKCYLRITGMTCSSCVNKVESHLLKVEGVKSVLVALLAMKCEIIYDSAYVMPFQLSNRVKELGFNAEV 1320
            R IV + GMTC +CV+NI+ TVG K GI+ I V LE+ +     ++    G  V E I+DMGF+ ++I +   +  A +P                ++S    EL+ N +          +   T  ++ +    C+  IE ++  + GV    V LI     + YD    +   IRE +   LGY   L          S   + N    SK  L I  ++  S  N++ESH+L   G+ S  V++      + +    + P  + N V+ LGF A++
Sbjct:    9 RAIVSIEGMTCHACVNNIQDTVGSKDGIVKIVVSLEQKQGTVDYNSEKWNGESVAESIDDMGFDCKLITD--QEIAAVEPQKASTTKLSISPLKTVDLSDGKVELQLNGVKYSKEGSSDHLEKCTFAVEGMTCASCVQYIERNISKIEGVHSIVVALIAAKAEVIYDGRVTSSDAIREHMTGELGYKATL--------LDSMGANPN---YSKIRLIIGNLSTESDANRIESHVLSKSGIDSCNVSIATSMALVEFSPQVIGPRDIINVVESLGFTADL 274          

Query: 3298 MAIDN-ELIAMISVADQVKREAALAVYTLKKMNIEVYLMTGDNSKTATAIARQVGI-----------------------------------------------HYVFAEVLPSHKVAKVQQLQNTNRSLTSKRKMKVAMVGDGINDSPALAQSDVGIAIG-TGTDVAVEAADVVLIRNSLLDVIAAIQLSKATVKRIRQNFIAATLYNLLG--IPIAAGVLMPIGIEMMP 3834
            + +DN + + M ++ D  + +   A+   K+  I+VY++TGD+  TATAIARQ+G+                                               + VFA   P HK+  V + Q        KR   V + GDG+ND+PAL ++DVG+A+G  G+DVA +AAD++L+ ++   ++A I+  +     +R+  IA T+ ++    +P+         + + P
Sbjct:  616 IPMDNWDFLGMSAIMDPPRDDTPRAIKACKEAGIKVYMVTGDHKSTATAIARQIGMIDTEEVTNLDHNRQVIRRTNSQDWAVITGPELPGLSEKQWDALLEHRYIVFARTTPEHKLMIVTESQ--------KRGECVTVTGDGVNDAPALKKADVGVAMGLAGSDVAKQAADIILLDDNFSSIVAGIEEGRLLFDNLRKT-IAYTMTHMWPELVPVMLNFFFGFPLGLTP 836          

Query: 3307 DNELIAMISVADQVKREAALAVYTLKKMNIEVYLMTGDNSKTATAIARQVGI-----------------------------------------------HYVFAEVLPSHKVAKVQQLQNTNRSLTSKRKMKVAMVGDGINDSPALAQSDVGIAIG-TGTDVAVEAADVVLIRNSLLDVIAAIQLSKATVKRIRQNFIAATLYNLLG--IPIAAGVLMPIGIEMMP 3834
            D + + M ++ D  + +   A+   K   I+VY++TGD+  TATAIARQ+G+                                               + VFA   P HK+  V + Q        KR   V + GDG+ND+PAL ++DVG+A+G  G+DVA +AAD++L+ ++   ++A I+  +     +R+  IA T+ ++    +P+         + + P
Sbjct:  616 DWDFLGMSAIMDPPRDDTPKAIKACKAAGIKVYMVTGDHKSTATAIARQIGMIDTEEVSRVDHNQQIIRRSNSQDWAVITGSELPALTQKQWDELLQHRYIVFARTTPEHKLMIVTESQ--------KRGECVTVTGDGVNDAPALKKADVGVAMGLAGSDVAKQAADIILLDDNFSSIVAGIEEGRLLFDNLRKT-IAYTMAHMWPELVPVILNFFFGFPLGLTP 832          

Query: 3307 DNELIAMISVADQVKREAALAVYTLKKMNIEVYLMTGDNSKTATAIARQVGI-----------------------------------------------HYVFAEVLPSHKVAKVQQLQNTNRSLTSKRKMKVAMVGDGINDSPALAQSDVGIAIG-TGTDVAVEAADVVLIRNSLLDVIAAIQLSKATVKRIRQNFIAATLYNLLG--IPIAAGVLMPIGIEMMP 3834
            D + + M ++ D  + +   A+   K   I+VY++TGD+  TATAIARQ+G+                                               + VFA   P HK+  V + Q        KR   V + GDG+ND+PAL ++DVG+A+G  G+DVA +AAD++L+ ++   ++A I+  +     +R+  IA T+ ++    +P+         + + P
Sbjct:  611 DWDFLGMSAIMDPPRDDTPKAIKACKAAGIKVYMVTGDHKSTATAIARQIGMIDTEEVSRVDHNQQIIRRSNSQDWAVITGSELPALTQKQWDELLQHRYIVFARTTPEHKLMIVTESQ--------KRGECVTVTGDGVNDAPALKKADVGVAMGLAGSDVAKQAADIILLDDNFSSIVAGIEEGRLLFDNLRKT-IAYTMAHMWPELVPVILNFFFGFPLGLTP 827          

Query:  580 GMTCQSCVDNIESTVGKKQGIISIKVFLEKSEAHALVDASLAGP-DVEEMINDMGFNSEMILEIFNDSCAGKPNNVSQKYEELKSNTIYPILSTTIVIKALKSIFCIFKIENHMRALPGVDKCSVNLIEEIGMIDYDSGKWNVQKIREEIESLGYLTEL--------------------------PKQNWNSTRQSSAVSLNEESRSKCYLRITGMTCSSCVNKVESHLLKVEGVKSVLVALLAMKCEIIYDSAYVMPFQLSNRVKELGFNAEVIENGNEGIGIVNVLIRGMTCSSCVNHIENHISKIKGIASINVSLSTSKGKVEYFISECGPRDVIDAINDMGFDASLC---DHLESNHAAADHINQMIKQWRSSFFFSLICGIPXXXXXXXXXXXXXXXXHTIIHENGSNRTIMKSTVPMVCSGLSADNLILFVLATPVQFYGARYFYIQAYLSLKHKTTNMDVLVVMATXXXXXXXXXXXXXXMAFRRNTSPKTFFETSPMLIVFLSLGRWLEHIAKGKTSEALTKLMSLQAVEATLY--TPEN---KERKIPINLVQRNDLIKILPGEKIPVDGKVVTGTSTCDESLITGESMPIEKTHGSDVIGGSINKSGMLIVKATHVGSDSALAQIVKLVEEAQTSKAPIQQLADRIAGMFVPSVLICAIITLIIWVIVGFSKPEILP---KYVNELSVTEITWEHAFQLAITVLSIACPCSLGLXXXXXXXXXXXXXXXNGILIKGGEPLENIHKLNVIVFDKTGTITNGSPSVTRFLVLIGNGVREHIDKLLKILAAAESASEHPIGKAIITFSKARISNENLPEV------LESSAVSGCGL 2979
            GMTCQSCV NI   +G+K GI+ ++V LE++  +   D     P  +   I+DMGF        +    A  P   +  +             T I +  +    C+  IE ++   PG+    V L  +   + YD  +++  +I E I+ +G+   +                          P  ++     + A+ + +E  +KC+L I GMTC+SCV  +E H  K+ G+ S+LVALLA K E+ +++  V    ++  + ELGF  E+I+  + G   V + I GMTC+SCVN IE+H+ KI+G+ + +V+L T +GK  Y   E GPR + +AI  +GF+A L    D +  N+   +H  + I++WR++F  SLI G P              + + ++  +      M   VP    GLS +NL++F+L+TPVQF+G  +FY+Q+Y ++KH TTNMDVL+ M T+ISY+YSV V++ ++   +N+SP TFF+T PML++F+SLGRWLEHIAKGKTSEAL+KL+SL+A +A L   +P+     E+ I ++ VQR D++K++PG K+PVDGKV+ G S+CDESLITGESMP+ K  GS VIGGSIN++G+L+V+ATH G ++ LAQIV+LVEEAQTSKAPIQQLADRIAG FVP V++ + ITLI W+I+GFS P ++P   ++   +    I   +AF+ A++VL+IACPC+LGLATPTAVMV TG GA+NG+L+KG   LEN HK+  +VFDKTGTIT+G+P  ++  + +   V   + + L I+ AAE  SEHPI  AI+ F+K  ++    P+           AV GCG+
Sbjct:   20 GMTCQSCVRNITEHIGQKSGILGVRVILEENAGYFDYDPRQTDPARIASDIDDMGFECS-----YPGDAADPPETPASAW-------------TNIRVVGMTCQSCVRNIEGNIGTKPGIHSIEVQLAAKNARVQYDPAQYDPAQIAELIDDMGFEASVQEPRSPSQSPSPAPASSPKKRATPTPPPPSYAQNGSAVAIPVEQELLTKCFLHIRGMTCASCVAAIEKHCKKIYGLDSILVALLAAKAEVKFNANVVTAENIAKSITELGFPTELIDEPDNGEAEVELEIMGMTCASCVNKIESHVLKIRGVTTASVTLLTKRGKFRYITEETGPRSICEAIEALGFEAKLMTGRDKMAHNY--LEH-KEEIRKWRNAFLVSLIFGGP----------CMVAMIYFMLEMSDKGHANMCCLVP----GLSMENLVMFLLSTPVQFFGGFHFYVQSYRAIKHGTTNMDVLISMVTTISYVYSVAVVIAAVLLEQNSSPLTFFDTPPMLLIFISLGRWLEHIAKGKTSEALSKLLSLKAADALLVEISPDFDIISEKVISVDYVQRGDILKVIPGAKVPVDGKVLYGHSSCDESLITGESMPVAKRKGSVVIGGSINQNGVLLVEATHTGENTTLAQIVRLVEEAQTSKAPIQQLADRIAGYFVPFVVVVSSITLIAWIIIGFSNPNLVPVAMEHKMHMDQNTIIVSYAFKCALSVLAIACPCALGLATPTAVMVATGTGAINGVLVKGATALENAHKVKTVVFDKTGTITHGTPMTSKVTLFVTAQVCS-LARALTIVGAAEQNSEHPIASAIVHFAKDMLNVGATPQAGSFGKSSHFQAVPGCGI 827          

Query: 3184 VTVIIGNRNWMLRNGILVDDEVDELMSEDENLGRTVILMAIDNELIAMISVADQVKREAALAVYTLKKMNIEVYLMTGDNSKTATAIARQVGIHYVFAEVLPSHKVAKVQQLQNTNRSLTSKRKMKVAMVGDGINDSPALAQSDVGIAIGTGTDVAVEAADVVLIRNSLLDVIAAIQLSKATVKRIRQNFIAATLYNLLGIPIAAGVLMPIGIEMMPWMXXXXXXXXXXXXXXXXXXXXXWKKPSEEKLITPEYINFIQSSGLSESQ-----IIVRRGID 4008
            + V+IGNR WM RN I V  E+ + M+ +E  G T +L A++ +L+ M +V+D VK EA LAVYTLK+M I+V L+TGDN  TA +IAR+VGI  V+AEVLPSHKVAK+Q++Q           ++VAMVGDG+NDSPALAQ+DVGI I  GTDVA EA+D+VL+RN LLDV+A + LS+ TV+RIR NF  A++YNLLGIP+A+G+  P G  ++PWMAS AMAASSVSVV  SLLLK+++KP+ + L T EY   + +   S S+     + + RG+D
Sbjct:  914 ILVLIGNREWMERNAIEVPLEISDCMTHEERKGHTAVLCALNGQLVCMFAVSDMVKPEAHLAVYTLKRMGIDVVLLTGDNKNTAASIAREVGIRTVYAEVLPSHKVAKIQRIQANG--------IRVAMVGDGVNDSPALAQADVGITIAAGTDVAAEASDIVLMRNDLLDVVACLDLSRCTVRRIRYNFFFASMYNLLGIPLASGLFAPYGFTLLPWMASVAMAASSVSVVCSSLLLKMYRKPTAKTLRTAEYEAQLAAERASGSEDELDKLSLHRGLD 1185          

Query:  568 VRVNGMTCQSCVDNIESTVGKKQGIISIKVFLEKSEAHALVDASLAGP-DVEEMINDMGFNSEM-----------ILEIFNDSCAGKPNNVSQKYEELKSNTIYPILSTTIV-----IKALKSIFCIFKIENHMRALPGVDKCSVNLIEEIGMIDYDSGKWNVQKIREEIESLGYLTELPKQNWNSTRQSSAVSLNEESRSKCYLRITGMTCSSCVNKVESHLLKVEGVKSVLVALLAMKCEIIYDSAYVMPFQLSNRVKELGFNAEVI 1323
            +RV GMTCQSCV NIE  +G K GI SI+V L    A    D +   P  + E+I+DMGF + +                +      P      Y +  S    P+    +      I+ +    C+  IE H + + G+D   V L+     + +++     + I + I  LG+ TEL             +   +   ++  L I GMTC+SCVNK+ESH+LK+ GV +  V LL  + +  Y +    P  +   ++ LGF A+++
Sbjct:   97 IRVVGMTCQSCVRNIEGNIGTKPGIHSIEVQLAAKNARVQYDPAQYDPAQIAELIDDMGFEASVQEPRSPSQSPSPAPASSPKKRATPTPPPPSYAQNGSAVAIPVEQELLTKCFLHIRGMTCASCVAAIEKHCKKIYGLDSILVALLAAKAEVKFNANVVTAENIAKSITELGFPTEL-------------IDEPDNGEAEVELEIMGMTCASCVNKIESHVLKIRGVTTASVTLLTKRGKFRYITEETGPRSICEAIEALGFEAKLM 352          

Query: 1105 EESRSKCYLRITGMTCSSCVNKVESHLLKVEGVKSVLVALLAMKCEIIYDSAYVMPFQLSNRVKELGFNAEVIENGNE-----GIGIVNVLIRGMTCSSCVNHIENHISKIKGIASINVSLSTSKGKVEYFISECGPRDVIDAINDMGFDASL 1548
            E + S   L I GMTC SCV  +  H+ +  G+  V V L        YD     P ++++ + ++GF      +  +          N+ + GMTC SCV +IE +I    GI SI V L+    +V+Y  ++  P  + + I+DMGF+AS+
Sbjct:    8 EATMSTVRLPIVGMTCQSCVRNITEHIGQKSGILGVRVILEENAGYFDYDPRQTDPARIASDIDDMGFECSYPGDAADPPETPASAWTNIRVVGMTCQSCVRNIEGNIGTKPGIHSIEVQLAAKNARVQYDPAQYDPAQIAELIDDMGFEASV 160          

Query:  112 MKVDGMTCMSCVRNIEENLMKFTGVCGIMVSLLHAEATVIFDADIATVEDISNKIDEMGFDVTVKSSEVSNVKDKVVRSRIKFESDINKSVEKSIETSLSSKLLLVRFCQENNYADIWHYSSIRSTEILSVIQQSEIYGVLVLEQCPTIRVIVRVNGMTCQSCVDNIESTVGKKQGIISIKVFLEKSEAHALVDAS-LAGPDVEEMINDMGFNSEMILEIFNDSCAGKPNNVSQKYEELKSNTIYPILSTTIVIKALKSIFCIFKIENHMRALPGVDKCSVNLIEEIGMIDYDSGKWNVQKIREEIESLGYLTEL 1053
            ++V GMTC SCVRNIE N+    G+  I V L    A V +D        I+  ID+MGF+        ++V++    S+    +  +   +++  T                      Y+   S   + V Q+       +L +C      + + GMTC SCV  IE    K  G+ SI V L  ++A    +A+ +   ++ + I ++GF +E+I E         P+N   + E              + I  +    C+ KIE+H+  + GV   SV L+ + G   Y + +   + I E IE+LG+  +L
Sbjct:   97 IRVVGMTCQSCVRNIEGNIGTKPGIHSIEVQLAAKNARVQYDPAQYDPAQIAELIDDMGFE--------ASVQEPRSPSQSPSPAPASSPKKRATPTPPPPS-----------------YAQNGSAVAIPVEQE-------LLTKC-----FLHIRGMTCASCVAAIEKHCKKIYGLDSILVALLAAKAEVKFNANVVTAENIAKSITELGFPTELIDE---------PDNGEAEVE--------------LEIMGMTCASCVNKIESHVLKIRGVTTASVTLLTKRGKFRYITEETGPRSICEAIEALGFEAKL 351          

Query:  580 GMTCQSCVDNIESTVGKKQGIISIKVFLEKSEAHALVDASLAGP-DVEEMINDMGFNSEMILEIFNDSCAGKPNNVSQKYEELKSNTIYPILSTTIVIKALKSIFCIFKIENHMRALPGVDKCSVNLIEEIGMIDYDSGKWNVQKIREEIESLGYLTEL--------------------------PKQNWNSTRQSSAVSLNEESRSKCYLRITGMTCSSCVNKVESHLLKVEGVKSVLVALLAMKCEIIYDSAYVMPFQLSNRVKELGFNAEVIENGNEGIGIVNVLIRGMTCSSCVNHIENHISKIKGIASINVSLSTSKGKVEYFISECGPRDVIDAINDMGFDASLC---DHLESNHAAADHINQMIKQWRSSFFFSLICGIPXXXXXXXXXXXXXXXXHTIIHENGSNRTIMKSTVPMVCSGLSADNLILFVLATPVQFYGARYFYIQAYLSLKHKTTNMDVLVVMATXXXXXXXXXXXXXXMAFRRNTSPKTFFETSPMLIVFLSLGRWLEHIAKGKTSEALTKLMSLQAVEATLY--TPEN---KERKIPINLVQRNDLIKILPGEKIPVDGKVVTGTSTCDESLITGESMPIEKTHGSDVIGGSINKSGMLIVKATHVGSDSALAQIVKLVEEAQTSKAPIQQLADRIAGMFVPSVLICAIITLIIWVIVGFSKPEILP---KYVNELSVTEITWEHAFQLAITVLSIACPCSLGLXXXXXXXXXXXXXXXNGILIKGGEPLENIHKLNVIVFDKTGTITNGSPSVTRFLVLIGNGVREHIDKLLKILAAAESASEHPIGKAIITFSKARISNENLPEV------LESSAVSGCGL 2979
            GMTCQSCV NI   +G+K GI+ ++V LE++  +   D     P  +   I+DMGF        +    A  P   +  +             T I +  +    C+  IE ++   PG+    V L  +   + YD  +++  +I E I+ +G+   +                          P  ++     + A+ + +E  +KC+L I GMTC+SCV  +E H  K+ G+ S+LVALLA K E+ +++  V    ++  + ELGF  E+I+  + G   V + I GMTC+SCVN IE+H+ KI+G+ + +V+L T +GK  Y   E GPR + +AI  +GF+A L    D +  N+   +H  + I++WR++F  SLI G P              + + ++  +      M   VP    GLS +NL++F+L+TPVQF+G  +FY+Q+Y ++KH TTNMDVL+ M T+ISY+YSV V++ ++   +N+SP TFF+T PML++F+SLGRWLEHIAKGKTSEAL+KL+SL+A +A L   +P+     E+ I ++ VQR D++K++PG K+PVDGKV+ G S+CDESLITGESMP+ K  GS VIGGSIN++G+L+V+ATH G ++ LAQIV+LVEEAQTSKAPIQQLADRIAG FVP V++ + ITLI W+I+GFS P ++P   ++   +    I   +AF+ A++VL+IACPC+LGLATPTAVMV TG GA+NG+L+KG   LEN HK+  +VFDKTGTIT+G+P  ++  + +   V   + + L I+ AAE  SEHPI  AI+ F+K  ++    P+           AV GCG+
Sbjct:   20 GMTCQSCVRNITEHIGQKSGILGVRVILEENAGYFDYDPRQTDPARIASDIDDMGFECS-----YPGDAADPPETPASAW-------------TNIRVVGMTCQSCVRNIEGNIGTKPGIHSIEVQLAAKNARVQYDPAQYDPAQIAELIDDMGFEASVQEPRSPSQSPSPAPASSPKKRATPTPPPPSYAQNGSAVAIPVEQELLTKCFLHIRGMTCASCVAAIEKHCKKIYGLDSILVALLAAKAEVKFNANVVTAENIAKSITELGFPTELIDEPDNGEAEVELEIMGMTCASCVNKIESHVLKIRGVTTASVTLLTKRGKFRYITEETGPRSICEAIEALGFEAKLMTGRDKMAHNY--LEH-KEEIRKWRNAFLVSLIFGGP----------CMVAMIYFMLEMSDKGHANMCCLVP----GLSMENLVMFLLSTPVQFFGGFHFYVQSYRAIKHGTTNMDVLISMVTTISYVYSVAVVIAAVLLEQNSSPLTFFDTPPMLLIFISLGRWLEHIAKGKTSEALSKLLSLKAADALLVEISPDFDIISEKVISVDYVQRGDILKVIPGAKVPVDGKVLYGHSSCDESLITGESMPVAKRKGSVVIGGSINQNGVLLVEATHTGENTTLAQIVRLVEEAQTSKAPIQQLADRIAGYFVPFVVVVSSITLIAWIIIGFSNPNLVPVAMEHKMHMDQNTIIVSYAFKCALSVLAIACPCALGLATPTAVMVATGTGAINGVLVKGATALENAHKVKTVVFDKTGTITHGTPMTSKVTLFVTAQVCS-LARALTIVGAAEQNSEHPIASAIVHFAKDMLNVGATPQAGSFGKSSHFQAVPGCGI 827          

Query: 3184 VTVIIGNRNWMLRNGILVDDEVDELMSEDENLGRTVILMAIDNELIAMISVADQVKREAALAVYTLKKMNIEVYLMTGDNSKTATAIARQVGIHYVFAEVLPSHKVAKVQQLQNTNRSLTSKRKMKVAMVGDGINDSPALAQSDVGIAIGTGTDVAVEAADVVLIRNSLLDVIAAIQLSKATVKRIRQNFIAATLYNLLGIPIAAGVLMPIGIEMMPWMXXXXXXXXXXXXXXXXXXXXXWKKPSEEKLITPEYINFIQSSGLSESQ-----IIVRRGID 4008
            + V+IGNR WM RN I V  E+ + M+ +E  G T +L A++ +L+ M +V+D VK EA LAVYTLK+M I+V L+TGDN  TA +IAR+VGI  V+AEVLPSHKVAK+Q++Q           ++VAMVGDG+NDSPALAQ+DVGI I  GTDVA EA+D+VL+RN LLDV+A + LS+ TV+RIR NF  A++YNLLGIP+A+G+  P G  ++PWMAS AMAASSVSVV  SLLLK+++KP+ + L T EY   + +   S S+     + + RG+D
Sbjct:  914 ILVLIGNREWMERNAIEVPLEISDCMTHEERKGHTAVLCALNGQLVCMFAVSDMVKPEAHLAVYTLKRMGIDVVLLTGDNKNTAASIAREVGIRTVYAEVLPSHKVAKIQRIQANG--------IRVAMVGDGVNDSPALAQADVGITIAAGTDVAAEASDIVLMRNDLLDVVACLDLSRCTVRRIRYNFFFASMYNLLGIPLASGLFAPYGFTLLPWMASVAMAASSVSVVCSSLLLKMYRKPTAKTLRTAEYEAQLAAERASGSEDELDKLSLHRGLD 1185          

Query:  568 VRVNGMTCQSCVDNIESTVGKKQGIISIKVFLEKSEAHALVDASLAGP-DVEEMINDMGFNSEM-----------ILEIFNDSCAGKPNNVSQKYEELKSNTIYPILSTTIV-----IKALKSIFCIFKIENHMRALPGVDKCSVNLIEEIGMIDYDSGKWNVQKIREEIESLGYLTELPKQNWNSTRQSSAVSLNEESRSKCYLRITGMTCSSCVNKVESHLLKVEGVKSVLVALLAMKCEIIYDSAYVMPFQLSNRVKELGFNAEVI 1323
            +RV GMTCQSCV NIE  +G K GI SI+V L    A    D +   P  + E+I+DMGF + +                +      P      Y +  S    P+    +      I+ +    C+  IE H + + G+D   V L+     + +++     + I + I  LG+ TEL             +   +   ++  L I GMTC+SCVNK+ESH+LK+ GV +  V LL  + +  Y +    P  +   ++ LGF A+++
Sbjct:   97 IRVVGMTCQSCVRNIEGNIGTKPGIHSIEVQLAAKNARVQYDPAQYDPAQIAELIDDMGFEASVQEPRSPSQSPSPAPASSPKKRATPTPPPPSYAQNGSAVAIPVEQELLTKCFLHIRGMTCASCVAAIEKHCKKIYGLDSILVALLAAKAEVKFNANVVTAENIAKSITELGFPTEL-------------IDEPDNGEAEVELEIMGMTCASCVNKIESHVLKIRGVTTASVTLLTKRGKFRYITEETGPRSICEAIEALGFEAKLM 352          

Query: 1105 EESRSKCYLRITGMTCSSCVNKVESHLLKVEGVKSVLVALLAMKCEIIYDSAYVMPFQLSNRVKELGFNAEVIENGNE-----GIGIVNVLIRGMTCSSCVNHIENHISKIKGIASINVSLSTSKGKVEYFISECGPRDVIDAINDMGFDASL 1548
            E + S   L I GMTC SCV  +  H+ +  G+  V V L        YD     P ++++ + ++GF      +  +          N+ + GMTC SCV +IE +I    GI SI V L+    +V+Y  ++  P  + + I+DMGF+AS+
Sbjct:    8 EATMSTVRLPIVGMTCQSCVRNITEHIGQKSGILGVRVILEENAGYFDYDPRQTDPARIASDIDDMGFECSYPGDAADPPETPASAWTNIRVVGMTCQSCVRNIEGNIGTKPGIHSIEVQLAAKNARVQYDPAQYDPAQIAELIDDMGFEASV 160          

Query:  112 MKVDGMTCMSCVRNIEENLMKFTGVCGIMVSLLHAEATVIFDADIATVEDISNKIDEMGFDVTVKSSEVSNVKDKVVRSRIKFESDINKSVEKSIETSLSSKLLLVRFCQENNYADIWHYSSIRSTEILSVIQQSEIYGVLVLEQCPTIRVIVRVNGMTCQSCVDNIESTVGKKQGIISIKVFLEKSEAHALVDAS-LAGPDVEEMINDMGFNSEMILEIFNDSCAGKPNNVSQKYEELKSNTIYPILSTTIVIKALKSIFCIFKIENHMRALPGVDKCSVNLIEEIGMIDYDSGKWNVQKIREEIESLGYLTEL 1053
            ++V GMTC SCVRNIE N+    G+  I V L    A V +D        I+  ID+MGF+        ++V++    S+    +  +   +++  T                      Y+   S   + V Q+       +L +C      + + GMTC SCV  IE    K  G+ SI V L  ++A    +A+ +   ++ + I ++GF +E+I E         P+N   + E              + I  +    C+ KIE+H+  + GV   SV L+ + G   Y + +   + I E IE+LG+  +L
Sbjct:   97 IRVVGMTCQSCVRNIEGNIGTKPGIHSIEVQLAAKNARVQYDPAQYDPAQIAELIDDMGFE--------ASVQEPRSPSQSPSPAPASSPKKRATPTPPPPS-----------------YAQNGSAVAIPVEQE-------LLTKC-----FLHIRGMTCASCVAAIEKHCKKIYGLDSILVALLAAKAEVKFNANVVTAENIAKSITELGFPTELIDE---------PDNGEAEVE--------------LEIMGMTCASCVNKIESHVLKIRGVTTASVTLLTKRGKFRYITEETGPRSICEAIEALGFEAKL 351          

Query: 3250 DELMSEDE-NLGRTVILMAIDNEL--IAMISVADQVKREAALAVYTLKKMNIEVYLMTGDNSKTATAIARQVGIH-------------------------------YVFAEVLPSHKVAKVQQLQNTNRSLTSKRKMKVAMVGDGINDSPALAQSDVGIAIGTGTDVAVEAADVVLIRNSLLDVIAAIQLSKATVKRIRQ---NFIAATLYNLLGIPIAAGVLMP 3813
            D  M  DE +LG +      +  L  + ++ + D  ++E   ++   +   I V ++TGDN  TA AI R++G+                                 +F+ V P HK   V+ LQ+ N           AM GDG+ND+PAL ++++GIA+G+GT VA  AA++VL  ++   +++A++  +A    ++Q     I++ +  ++ I + A + +P
Sbjct:  568 DSPMKPDEMDLGDSTKFYQYEVNLTFVGVVGMLDPPRKEVFDSIVRCRAAGIRVIVITGDNKATAEAICRRIGVFAEDEDTTGKSYSGREFDDLSPTEQKAAVARSRLFSRVEPQHKSKIVEFLQSMNEI--------SAMTGDGVNDAPALKKAEIGIAMGSGTAVAKSAAEMVLADDNFSSIVSAVEEGRAIYNNMKQFIRYLISSNIGEVVSIFLTAALGLP 784          

Query: 3250 DELMSEDE-NLGRTVILMAIDNEL--IAMISVADQVKREAALAVYTLKKMNIEVYLMTGDNSKTATAIARQVGIH-------------------------------YVFAEVLPSHKVAKVQQLQNTNRSLTSKRKMKVAMVGDGINDSPALAQSDVGIAIGTGTDVAVEAADVVLIRNSLLDVIAAIQLSKATVKRIRQ---NFIAATLYNLLGIPIAAGVLMP 3813
            D  M  DE +LG +      +  L  + ++ + D  ++E   ++   +   I V ++TGDN  TA AI R++G+                                 +F+ V P HK   V+ LQ+ N           AM GDG+ND+PAL ++++GIA+G+GT VA  AA++VL  ++   +++A++  +A    ++Q     I++ +  ++ I + A + +P
Sbjct:  568 DSPMKPDEMDLGDSTKFYQYEVNLTFVGVVGMLDPPRKEVFDSIVRCRAAGIRVIVITGDNKATAEAICRRIGVFAEDEDTTGKSYSGREFDDLSPTEQKAAVARSRLFSRVEPQHKSKIVEFLQSMNEI--------SAMTGDGVNDAPALKKAEIGIAMGSGTAVAKSAAEMVLADDNFSSIVSAVEEGRAIYNNMKQFIRYLISSNIGEVVSIFLTAALGLP 784          

Query: 3250 DELMSEDE-NLGRTVILMAIDNEL--IAMISVADQVKREAALAVYTLKKMNIEVYLMTGDNSKTATAIARQVGIH-------------------------------YVFAEVLPSHKVAKVQQLQNTNRSLTSKRKMKVAMVGDGINDSPALAQSDVGIAIGTGTDVAVEAADVVLIRNSLLDVIAAIQLSKATVKRIRQ---NFIAATLYNLLGIPIAAGVLMP 3813
            D  M  DE +LG +      +  L  + ++ + D  ++E   ++   +   I V ++TGDN  TA AI R++G+                                 +F+ V P HK   V+ LQ+ N           AM GDG+ND+PAL ++++GIA+G+GT VA  AA++VL  ++   +++A++  +A    ++Q     I++ +  ++ I + A + +P
Sbjct:  568 DSPMKPDEMDLGDSTKFYQYEVNLTFVGVVGMLDPPRKEVFDSIVRCRAAGIRVIVITGDNKATAEAICRRIGVFAEDEDTTGKSYSGREFDDLSPTEQKAAVARSRLFSRVEPQHKSKIVEFLQSMNEI--------SAMTGDGVNDAPALKKAEIGIAMGSGTAVAKSAAEMVLADDNFSSIVSAVEEGRAIYNNMKQFIRYLISSNIGEVVSIFLTAALGLP 784          

Query:  562 VIVRVNGMTCQSCVDNIESTVGKKQGIISIKVFLEK--------SEAHALVDASLAGP---DVEEMINDM-GFNSEMI------LEIFNDSCAGKPNNVSQKYEELKSNTI-YPILSTTIVIKALKSIFCIFKIENHMRALPGVDKCSVNLIEEIGMIDYDSGKWNVQKIREEIESLGYLTELPKQNWN--STRQSSAVSLNEESRSKCYLRITGMTCSSCVNKVESHLLKVEGVKSVLVALLAMKCEIIYDSAYVMPFQLSNRVKELGFNAEVIENGNEGIGIVNVLIRGMTCSSCVNHIENHISKIKGIASINVSLSTSKGKVEYFISECGPRDVIDAINDMGFDASLCDHLESNHAAADHINQMIKQWRSSFFFSLICGIPXXXXXXXXXXXXXXXXHTIIHENGSNRTIMKSTVPMVCSGLSADNLILFVLATPVQFYGARYFYIQAYLSLKHKTTNMDVLVVMATXXXXXXXXXXXXXXMAFRRNTSPKTFFETSPMLIVFLSLGRWLEHIAKGKTSEALTKLMSLQAVEATLYT--PEN---KERKIPINLVQRNDLIKILPGEKIPVDGKVVTGTSTCDESLITGESMPIEKTHGSDVIGGSINKSGMLIVKATHVGSDSALAQIVKLVEEAQTSKAPIQQLADRIAGMFVPSVLICAIITLIIWVIVGFSKPEI----LPKYVNELSVTEITWEHAFQLAITVLSIACPCSLGLXXXXXXXXXXXXXXXNGILIKGGEPLENIHKLNVIVFDKTGTITNGSPSVTRFLVLIGNGVREHIDKLLKILAAAESASEHPIGKAIITFSKARISNENLPEVLESSAVSGCGLGCKLNLDPKTEVTKFVKNLINIESPSEETNILGQXXXXXXXXXXXXTYKDVIFPVRQHMAWTSDLCQTVTVIIGNRNWMLRNGILVDDEVDELMSEDENLGRTVILMAIDNELIAMISVADQVKREAALAVYTLKKMNIEVYLMTGDNSKTATAIARQVGIHYVFAEVLPSHKVAKVQQLQNTNRSLTSKRKMKVAMVGDGINDSPALAQSDVGIAIGTGTDVAVEAADVVLIRNSLLDVIAAIQLSKATVKRIRQNFIAATLYNLLGIPIAAGVLMPIGIEMMPWM 3840
            V ++V GMTCQSCV +IE  +G+ +G+I ++V L          SE    V+    G    ++ E ++ M G NS  +      +++  D        V    EE+  N+   P  S TI I+ +    C+  IE  M    GV    V L E+ G++ +DS     +++R EIE +G+   L +  +     +  +A    E    KC++ +TGMTC+SCV+ +E +L+K EG+KSVLVAL+A K E+ YD   + P Q+   +  LGF A V+E  +   G++++ + GMTC+SCV++IE+ + + KGI   +V+L+T+K  V++     G RD++  I  +GF  SL  + E  +   DH  + I+QW+ SF FSL+ GIP M +M++ M            E+G +    ++ +P    GLS  NL  F+L TPVQF G RYFYIQAY SL+H   NMDVL+V+AT+I+Y+YS  V++++M      SP TFF+T PML VF++LGRWLEH+AK KTSEAL KLMSLQA +AT+ +  P+N   +E ++ ++LVQR D++K+ PG K PVDGKV+ GTS  DESLITGE MP+ K  GS VI GSIN  G L+V+ATHVGS++ L+QIVKLVEEAQTSKAPIQQLAD+++G FVP +++ +I+T+  W+I+GF   ++     P Y   +S TE+    AFQ +ITVLSIACPCSLGLATPTAVMVGTGVGA NGILIKGGEPLE  HK+  ++FDKTGTITNG P VTR LVL  +  R  +  +L ++  AE++SEHP+G A+    K  +  E L    +  AV GCG+ CK++          V++L+     ++E++++    +                         SD   + +V+IGNR WMLRNG+ V  +VD  MS  E  G+T IL+AID  L AMI+VAD VK E+ALAV+TL  M IEVY++TGDN +TA AIA QVGI  VFAEVLPSHKVAKVQ+LQ        +R +KVAMVGDG+NDSPALA +D+GIAIGTGTDVA+EAAD+VLIRN LLDV+A+I+LSK TV+RIR NF+ A +YNLLGIP AAGV MP+G+ + PWM
Sbjct:   63 VKIQVEGMTCQSCVRSIEEQIGRLEGVIGVQVSLSDKEPLSTDWSEVTLGVEGMHCGSCVKNITETLSGMLGVNSVFVSLEKGSVDLRFDPSLLTLETVKGFLEEIPLNSASTPTQSVTIGIEGMTCNSCVQAIEGMMSQRAGVCSIKVYLQEKKGIVTFDSTVTCPEELRAEIEDMGFEAWLNQGRYLLIHNKYKNADGTGERELRKCFVHVTGMTCASCVSNIERNLVKHEGIKSVLVALMAGKAEVKYDPGLLDPAQIVQLISHLGFGASVMEEHSVQDGVLDLSVTGMTCASCVHNIESKLLRTKGIQEASVALATNKAHVKFDSDLVGSRDIVRIIEGLGFGVSLIKN-EGLNNTLDH-QEEIRQWKHSFLFSLVFGIPVMGLMIYMMVMDSQH-----KEHGGSMPADQNILP----GLSIINLAFFLLCTPVQFLGGRYFYIQAYRSLRHGVANMDVLIVLATTIAYVYSFTVLIVAMIEGAKQSPLTFFDTPPMLFVFIALGRWLEHVAKSKTSEALAKLMSLQATDATIVSLGPDNTIIREEQVSVDLVQRGDVVKVAPGGKFPVDGKVIEGTSMADESLITGEPMPVIKKAGSCVIAGSINAHGALLVEATHVGSETTLSQIVKLVEEAQTSKAPIQQLADKLSGYFVPFIVVISILTVTAWLIIGFLDFDVVSKNFPGYNQNISRTEVIVRFAFQASITVLSIACPCSLGLATPTAVMVGTGVGAQNGILIKGGEPLEMAHKVGAVMFDKTGTITNGVPQVTRVLVLW-DRARLPLRTVLAVVGTAEASSEHPLGMAVAKHCKEELGAETLGFCHDFQAVPGCGISCKVS---------SVEDLLQNRVTTDESSLVADTDSG------------------------SD-SPSYSVLIGNRQWMLRNGLEVTADVDNAMSSHETKGQTAILVAIDGVLCAMIAVADTVKAESALAVHTLSSMGIEVYMITGDNRRTARAIATQVGIRKVFAEVLPSHKVAKVQELQ--------ERGLKVAMVGDGVNDSPALAHADLGIAIGTGTDVAIEAADIVLIRNDLLDVVASIELSKKTVQRIRINFVFALIYNLLGIPFAAGVFMPLGLVLQPWM 1131          

Query:  100 GSARMKVDGMTCMSCVRNIEENLMKFTGVCGIMVSLLHAEATVIFDADIATVEDISNKIDEMGFDVTVKSSEVSNVKDKVVRSRIKFESDINKSVEKSIETSLSSKLLL--VRFCQENNYADIWHYSSIRSTEILSVIQQSEIYGVLVLEQCPTIRVIVRVNGMTCQSCVDNIESTVGKKQGIISIKVFLEKSEAHALVDASLAGP-DVEEMINDMGFNSEMILEIFNDSCAGKPNNVSQKYEELKSNTIYPILSTTIVIKALKSIFCIFKIENHMRALPGVDKCSVNLIEEIGMIDYDSGKWNVQKIREEIESLGYLTELPKQNWNSTRQSSAVSLNEESRSKCYLRITGMTCSSCVNKVESHLLKVEGVKSVLVALLAMKCEIIYDSAYVMPFQLSNRVKELGFNAEVIEN 1329
            G  +++V+GMTC SCVR+IEE + +  GV G+ VS             ++  E +S    E+   V                     E     S  K+I  +LS  L +  V    E    D+    S+ + E +    + EI   L     PT  V + + GMTC SCV  IE  + ++ G+ SIKV+L++ +     D+++  P ++   I DMGF + +          G+   +  KY+         +    + +  +    C+  IE ++    G+    V L+     + YD G  +  +I + I  LG+   + +++   + Q   + L+          +TGMTC+SCV+ +ES LL+ +G++   VAL   K  + +DS  V    +   ++ LGF   +I+N
Sbjct:   61 GMVKIQVEGMTCQSCVRSIEEQIGRLEGVIGVQVS-------------LSDKEPLSTDWSEVTLGV---------------------EGMHCGSCVKNITETLSGMLGVNSVFVSLEKGSVDLRFDPSLLTLETVKGFLE-EIP--LNSASTPTQSVTIGIEGMTCNSCVQAIEGMMSQRAGVCSIKVYLQEKKGIVTFDSTVTCPEELRAEIEDMGFEAWL--------NQGRYLLIHNKYKNADGTGERELRKCFVHVTGMTCASCVSNIERNLVKHEGIKSVLVALMAGKAEVKYDPGLLDPAQIVQLISHLGFGASVMEEH---SVQDGVLDLS----------VTGMTCASCVHNIESKLLRTKGIQEASVALATNKAHVKFDSDLVGSRDIVRIIEGLGFGVSLIKN 415          

Query:  100 GSARMKVDGMTCMSCVRNIEENLMKFTGVCGIMVSLLHAEATVIFDADIATVEDISNKIDEMGFDVT-VKSSEVSNVKD 333
            G   + V GMTC SCV NIE  L++  G+    V+L   +A V FD+D+    DI   I+ +GF V+ +K+  ++N  D
Sbjct:  345 GVLDLSVTGMTCASCVHNIESKLLRTKGIQEASVALATNKAHVKFDSDLVGSRDIVRIIEGLGFGVSLIKNEGLNNTLD 423          

Query:  103 SARMKVDGMTCMSCVRNIEENLMKFTGVCGIMVSLLHAEATVIFDADIATVEDISNKIDEMGFDVTVKSSEVSNVKDKVVRSRIKFESDINKSVEKSIETSLSSKLLLVRFCQENNYADIWHYSSIRSTEILSVIQQSEIYGVLVLEQCP---TIRVIVRVNGMTCQSCVDNIESTVGKKQGIISIKVFLEKSEAHALVDA-SLAGPDVEEMINDMGFNSEMILEIFNDSCAGKPNNVSQKYEELKSNTIYPILSTT-IVIKALKSIFCIFKIENHMRALPGVDKCSVNLIEEIGMIDYDSGKWNVQKIREEIESLGYLTELPKQN----------------WNSTRQSSAVSLNEESR---------SKCYLRITGMTCSSCVNKVESHLLKVEGVKSVLVALLAMKCEIIYDSAYVMPFQLSNRVKELGFNAEVIENGNEGIGIVNVLIRGMTCSSCVNHIENHISKIKGIASINVSLSTSKGKVEYFISECGPRDVIDAINDMGFDASLCDHLESNHAAADHINQMIKQWRSSFFFSLICGIPXXXXXXXXXXXXXXXXHTIIHENGS--NRTIMKSTVPM---VCSGLSADNLILFVLATPVQFYGARYFYIQAYLSLKHKTTNMDVLVVMATXXXXXXXXXXXXXXMAFRRNTSPKTFFETSPMLIVFLSLGRWLEHIAKGKTSEALTKLMSLQAVEATLYTPEN-----KERKIPINLVQRNDLIKILPGEKIPVDGKVVTGTSTCDESLITGESMPIEKTHGSDVIGGSINKSGMLIVKATHVGSDSALAQIVKLVEEAQTSKAPIQQLADRIAGMFVPSVLICAIITLIIWVIVGFSKPEI----LPKYVNELSVTEITWEHAFQLAITVLSIACPCSLGLXXXXXXXXXXXXXXXNGILIKGGEPLENIHKLNVIVFDKTGTITNGSPSVTRFLVLIGNGVREHIDKLLKILAAAESASEHPIGKAIITFSKARISNENLPEVLESSAVSGCGLGCKLNLDPKTEVTKFVKNLINIESPSEETNILGQXXXXXXXXXXXXTYKDVIF-PVRQHMAWTSDLCQTVTVIIGNRNWMLRNGILVDDEVDELMSEDENLGRTVILMAIDNELIAMISVADQVKREAALAVYTLKKMNIEVYLMTGDNSKTATAIARQVGIHYVFAEVLPSHKVAKVQQLQNTNRSLTSKRKMKVAMVGDGINDSPALAQSDVGIAIGTGTDVAVEAADVVLIRNSLLDVIAAIQLSKATVKRIRQNFIAATLYNLLGIPIAAGVLMPIGIEMMPWMXXXXXXXXXXXXXXXXXXXXXWKKPSEEKL 3930
            + +M+++GM C+SC   IE  + K  GV  I VSL   EA V++   I TV++I  +I+  GF  TV                        KS  + ++ S S                           +LS  +Q+E      L + P   T+  + +V GM C SCV NI+  + K   + S+ V LE  +A    +   ++  ++++ I  +   +      F       P          +   + P++S   I I+ +    C+  IE  +    GV    V+L    G  +YD    + +++R  IE +G+   LP+ N                 + +   SAV  NE            SKC+++I GMTC+SCV  +E +L    G+ SVLVAL+A K E+ Y  + + P +++  ++ELGF A V++N +   G + +++RGMTC+SCV+ IE+++ K KGI   +V+LST+K  ++Y     GPRD+I  I +MGF ASL    +   +  DH ++ I+QW+ SF  SL   +P M +M++ +    M+     H N +  +R    ST+ +   +  GLS  NLI F+   PVQF G RYFY QAY ++KH+T NMDVL+V+AT+I++ YSV+V++++M  R   +P TFF+T PML VF+SLGRWLE IAK KTSEAL+KLMSLQA EAT+ T         E ++ + LVQR D++K++PG K PVDG+V+ G S  DESLITGE+MP+ K  GS VI GSIN++G L++KATHVG+D+ L+QIVKLVEEAQTSKAPIQQ AD+I+  FVP +++ +++TL+ W+I+GF    +     P Y   +S  E     AFQ +ITVL IACPCSLGLATPTAVMVGTGVGA NGILIKGGEPLE  HK+  +VFDKTGTIT G+P V + + ++  G R    KLL I+  AE++SEHP+G AI  + K  +  E+L    +  AV GCG+ C   L   TE      NL+  E    E N     +    +     T   +I  P    +  T+    + TV+IGNR WM RN + V  +VDE M+E E  G T +L+A+DNEL AM+++AD VK EA LAV+ L  M +EV LMTGDNSKTA AIA QVGI  VFAEVLPSHKVAKV+QLQ   +        +VAMVGDG+NDSPALA +DVGIAIGTGTDVA+EAADVVLIRN LLDV+ +I LSK TVKRIR NF+ A +YNL+GIPIAAGV MP+G+ + PWM SAAMA SSVSVV  SLLLK + KP+ EKL
Sbjct:  172 AVKMRIEGMVCLSCTTTIEGKIGKLKGVEKIKVSLESQEAAVVYLPYIITVDEIVKQIEVAGFKATV------------------------KSKPRQLKLSAS-----------------------EVERLLSAPKQTEEK----LSEPPADSTVTTLFQVTGMHCNSCVVNIQDNISKLPAVTSVVVSLENRQASIQHNPKQVSAVELQKAIEALPPGN------FKAIIPASP----------EPGFLQPLVSVAEIHIEGMTCGSCVQSIEGTLSQKKGVRSAQVSLANHKGTFEYDPLLTSPEELRAAIEDMGFDAFLPETNSLVPSVVKSPSLSVRSSSLSPVRSAVKENEAESDAEPSTNTISKCFIQIGGMTCASCVANIERNLKNEYGIHSVLVALMASKAEVRYSPSVIDPLRIAELIRELGFTATVMDNYDGSDGSLELVVRGMTCASCVHKIESNLMKQKGILYASVALSTNKAHIKYDPEVTGPRDIIRLIENMGFTASLVKK-DRPGSHLDH-SREIRQWKRSFQISLFFCVPVMGMMIYMIVVDHMIDKYHQHHNATAEDRAKYHSTMFLEKQLLPGLSIMNLISFLFCVPVQFIGGRYFYCQAYKAVKHRTANMDVLIVLATTIAFTYSVVVLLVAMVERAKVNPITFFDTPPMLFVFISLGRWLEQIAKSKTSEALSKLMSLQATEATVVTLNEDMSVLSEEQVDVELVQRGDVVKVVPGGKFPVDGRVIEGHSMADESLITGEAMPVTKKPGSTVIAGSINQNGSLLIKATHVGTDTTLSQIVKLVEEAQTSKAPIQQFADKISSYFVPFIVVISVLTLLAWIIIGFVNFSLVQTYFPGYDKSISEAEAVIRFAFQASITVLCIACPCSLGLATPTAVMVGTGVGAQNGILIKGGEPLEMAHKIQSVVFDKTGTITYGAPKVVQ-VKMLAEGNRLPRSKLLAIVGTAENSSEHPLGAAITKYCKQELGTESLGTCTDFQAVPGCGIRC---LVSNTE------NLLKREDSDSEENQHNAVLIQISDARAHSTEHPLIMDPQPLTVVQTA----SYTVLIGNREWMRRNALQVRADVDEAMTEHERRGCTAVLVAVDNELCAMVAIADTVKPEAELAVHVLSAMGLEVVLMTGDNSKTARAIAAQVGIRKVFAEVLPSHKVAKVEQLQQEGK--------RVAMVGDGVNDSPALAMADVGIAIGTGTDVAIEAADVVLIRNDLLDVVGSIDLSKKTVKRIRINFVFALMYNLVGIPIAAGVFMPVGLVLQPWMGSAAMALSSVSVVLSSLLLKCYTKPTVEKL 1401          

Query:   79 LAIRMKLGSARMKVDGMTCMSCVRNIEENLMKFTGVCGIMVSLLHAEATVIFDADIATVEDISNKIDEMGFDVTVKSSEVSNVKDKVVRSRIKFESDINKSVEKSIETSLSSKLLLVRFCQENNYADIWHYSSIRSTEILSVIQQSEIYGVLVLEQC--PTIR---------------VIVRVNGMTCQSCVDNIESTVGKKQGIISIKVFLEKSEAHALVDASLAGPDVEEMINDMGFNSEMILEIFNDSCAGKPNNV--------------SQKYEELKSNTIYPILSTTIVIKALKSIFCIFKIENHMRALPGVDKCSVNLIEEIGMIDYDSGKWNVQKIREEIESLGYLTELPKQNWNSTRQSSA-VSLNEESRSKCYLRITGMTCSSCVNKVESHLLKVEGVKSVLVALLAMKCEIIYDSAYVMPFQLSNRVKELGFNA------------------------------EVIENGNEG--------IGIVNVLIRGMTCSSCVNHIENHISKIKGIASINVSLSTSKGKVEYFISECGPRDVIDAINDMGFDASLCDHLESN 1569
            +A+   L    + V+GMTC SCV++IE  +    GV  I VSL    ATV +D    T + I++ I++MGF+     S ++N     V++  K  S    S + S++ +LS+   +    +    AD    +      ++S  Q  E+   L  +    P +                V +R+ GM C SC   IE  +GK +G+  IKV LE  EA  +    +    V+E++  +          F  +   KP  +               Q  E+L        ++T   +  +    C+  I++++  LP V    V+L      I ++  + +  ++++ IE+      LP  N+ +   +S      +   S   + I GMTC SCV  +E  L + +GV+S  V+L   K    YD     P +L   ++++GF+A                               V EN  E         I    + I GMTC+SCV +IE ++    GI S+ V+L  SK +V Y  S   P  + + I ++GF A++ D+ + +
Sbjct:    1 MALSTNLCRVTLGVEGMTCGSCVQSIEGRIGGLPGVIHIQVSLEQNNATVTYDHTQHTPQSIADAIEDMGFE-----SSLTNATSTPVQTETKVFSKAGCSAD-SVQQALSTLAQIKGVIETQESADNQGLAVTFVPSLVSEDQLGEVLKCLAPDTACRPPLSPKEGSTSRSFSGVEAVKMRIEGMVCLSCTTTIEGKIGKLKGVEKIKVSLESQEAAVVYLPYII--TVDEIVKQIEVAG------FKATVKSKPRQLKLSASEVERLLSAPKQTEEKLSEPPADSTVTTLFQVTGMHCNSCVVNIQDNISKLPAVTSVVVSLENRQASIQHNPKQVSAVELQKAIEA------LPPGNFKAIIPASPEPGFLQPLVSVAEIHIEGMTCGSCVQSIEGTLSQKKGVRSAQVSLANHKGTFEYDPLLTSPEELRAAIEDMGFDAFLPETNSLVPSVVKSPSLSVRSSSLSPVRSAVKENEAESDAEPSTNTISKCFIQIGGMTCASCVANIERNLKNEYGIHSVLVALMASKAEVRYSPSVIDPLRIAELIRELGFTATVMDNYDGS 547          

Query:  100 GSARMKVDGMTCMSCVRNIEENLMKFTGVCGIMVSLLHAEATVIFDADIATVEDISNKIDEMGFDVTV 303
            GS  + V GMTC SCV  IE NLMK  G+    V+L   +A + +D ++    DI   I+ MGF  ++
Sbjct:  549 GSLELVVRGMTCASCVHKIESNLMKQKGILYASVALSTNKAHIKYDPEVTGPRDIIRLIENMGFTASL 616          

Query:  559 RVIVRVNGMTCQSCVDNIESTVGKKQGIISIKVFLEKSEAHALVDASLAGPDVEEMINDMGFNSEMILEIFNDSCAGKPNNVSQKYEELKSNTIYPILSTTIVIKALKSIFCIFKIENHMRALPGVDKCSVNLIEEIGMIDYDSGKWNVQKIREEIESLGY----------------------LTELPKQNWNSTRQSSAVS------LNEESRSKCYLRITGMTCSSCVNKVESHLLKVEGVKSVLVALLAMKCEIIYDSAYVMPFQLSNRVKELGFNAEVIENGNEGIGIVNVLIRGMTCSSCVNHIENHISKIKGIASINVSLSTSKGKVEYFISECGPRDVIDAINDMGFDASLCDHLESNHAAADHINQMIKQWRSSFFFSLICGIPXXXXXXXXXXXXXXXXHTIIHENGSNRTIMKSTVPMVCSGLSADNLILFVLATPVQFYGARYFYIQAYLSLKHKTTNMDVLVVMATXXXXXXXXXXXXXXMAFRRNTSPKTFFETSPMLIVFLSLGRWLEHIAKGKTSEALTKLMSLQAVEATLYT--PEN---KERKIPINLVQRNDLIKILPGEKIPVDGKVVTGTSTCDESLITGESMPIEKTHGSDVIGGSINKSGMLIVKATHVGSDSALAQIVKLVEEAQTSKAPIQQLADRIAGMFVPSVLICAIITLIIWVIVGFSKPEI----LPKYVNELSVTEITWEHAFQLAITVLSIACPCSLGLXXXXXXXXXXXXXXXNGILIKGGEPLENIHKLNVIVFDKTGTITNGSPSVTRFLVLIGNGVREHIDKLLKILAAAESASEHPIGKAIITFSKARISNENLPEVLESSAVSGCGLGCK-------LNLDPKTEVTKFVKNLINIESPSEETNILGQXXXXXXXXXXXXTYKDVIFPVRQHMAWTSDLCQTVTVIIGNRNWMLRNGILVDDEVDELMSEDENLGRTVILMAIDNELIAMISVADQVKREAALAVYTLKKMNIEVYLMTGDNSKTATAIARQVGIHYVFAEVLPSHKVAKVQQLQNTNRSLTSKRKMKVAMVGDGINDSPALAQSDVGIAIGTGTDVAVEAADVVLIRNSLLDVIAAIQLSKATVKRIRQNFIAATLYNLLGIPIAAGVLMPIGIEMMPWMXXXXXXXXXXXXXXXXXXXXXWKKPSEEKLITPEYINFIQSS--GLSESQIIVRRGID 4008
             V + V GM C SCV NI  T+    G+ S+ V LEK       D SL   +  +     GF  E+    F  S  G        +    ++   P  S TI I+ +    C+  IE  M    GV    V L E+ G++ +DS     +++R EIE +G+                      L  LP Q   S    S ++        E    KC++ +TGMTC+SCV+ +E +L+K EG+KSVLVAL+A K E+ YD   + P Q+   +  LGF A V+E  +   G++++ + GMTC+SCV++IE+ + + KGI   +V+L+T+K  V++     G RD++  I  +GF  SL  + E  +   DH  ++  +W+ SF FSL+ GIP M +M++ M            E+G +    ++ +P    GLS  NL  F+L TPVQF G RYFYIQAY SL+H   NMDVL+V+AT+I+Y+YS  V++++M      SP TFF+T PML VF++LGRWLEH+AK KTSEAL KLMSLQA +AT+ +  P+N   +E ++ ++LVQR D++K+ PG K PVDGKV+ GTS  DESLITGE MP+ K  GS VI GSIN  G L+V+ATHVGS++ L+QIVKLVEEAQTSKAPIQQLAD+++G FVP +++ +I+T+  W+I+GF   ++     P Y   +S TE+    AFQ +ITVLSIACPCSLGLATPTAVMVGTGVGA NGILIKGGEPLE  HK+  ++FDKTGTITNG P VTR LVL  +  R  +  +L ++  AE++SEHP+G A+    K  +  E L    +  AV GCG+ CK       L   PKT+ TK         S  ++T +L     +  ++   +   D           +     + +V+IGNR WMLRNG+ V  +VD  MS  E  G+T IL+AID  L AMI+VAD VK E+ALAV+TL  M IEVY++TGDN +TA AIA QVGI  VFAEVLPSHKVAKVQ+LQ        +R +KVAMVGDG+NDSPALA +D+GIAIGTGTDVA+EAAD+VLIRN LLDV+A+I+LSK TV+RIR NF+ A +YNLLGIP AAGV MP+G+ + PWM SAAMAASSVSVV  SLLL+L+KK S E     EY +  QS    LS SQ+    G++
Sbjct:  182 EVTLGVEGMHCGSCVKNITETLSGMLGVNSVFVSLEKGSVDLRFDPSLLTLETVK-----GFLEEIPPGNFRVSIPG--------WSSRLNSASTPTQSVTIGIEGMTCNSCVQAIEGMMSQRAGVCSIKVYLQEKKGIVTFDSTVTCPEELRAEIEDMGFEAWLNQDSEICEVSSVSQMPSGLKHLPSQRHPSKPSPSPITKENADGTGERELRKCFVHVTGMTCASCVSNIERNLVKHEGIKSVLVALMAGKAEVKYDPGLLDPAQIVQLISHLGFGASVMEEHSVQDGVLDLSVTGMTCASCVHNIESKLLRTKGIQEASVALATNKAHVKFDSDLVGSRDIVRIIEGLGFGVSLIKN-EGLNNTLDHQEEI--RWKHSFLFSLVFGIPVMGLMIYMMVMDSQH-----KEHGGSMPADQNILP----GLSIINLAFFLLCTPVQFLGGRYFYIQAYRSLRHGVANMDVLIVLATTIAYVYSFTVLIVAMIEGAKQSPLTFFDTPPMLFVFIALGRWLEHVAKSKTSEALAKLMSLQATDATIVSLGPDNTIIREEQVSVDLVQRGDVVKVAPGGKFPVDGKVIEGTSMADESLITGEPMPVIKKAGSCVIAGSINAHGALLVEATHVGSETTLSQIVKLVEEAQTSKAPIQQLADKLSGYFVPFIVVISILTVTAWLIIGFLDFDVVSKNFPGYNQNISRTEVIVRFAFQASITVLSIACPCSLGLATPTAVMVGTGVGAQNGILIKGGEPLEMAHKVGAVMFDKTGTITNGVPQVTRVLVLW-DRARLPLRTVLAVVGTAEASSEHPLGMAVAKHCKEELGAETLGFCHDFQAVPGCGISCKVSSVEDLLQNSPKTQETK--------ASAVKQTPLLVTLQGVTTDESSLVADTD-----------SGSDSPSYSVLIGNRQWMLRNGLEVTADVDNAMSSHETKGQTAILVAIDGVLCAMIAVADTVKAESALAVHTLSSMGIEVYMITGDNRRTARAIATQVGIRKVFAEVLPSHKVAKVQELQ--------ERGLKVAMVGDGVNDSPALAHADLGIAIGTGTDVAIEAADIVLIRNDLLDVVASIELSKKTVQRIRINFVFALIYNLLGIPFAAGVFMPLGLVLQPWMGSAAMAASSVSVVLSSLLLRLFKKTSVE-----EYESRAQSHKLSLSPSQVSTHVGLE 1319          

Query:  100 GSARMKVDGMTCMSCVRNIEENLMKFTGVCGIMVSLLHAEATVIFDADIATVEDISNKIDEMGFDVTVKS--SEVSNVKDKVVRSRIKFESDINKSVEKSIETSLSSKLLL--VRFCQENNYADIWHYSSIRSTEILSVIQQSEIYGVLVLE-----------QCPTIRVIVRVNGMTCQSCVDNIESTVGKKQGIISIKVFLEKSEAHALVDASLAGP-DVEEMINDMGFNSEM-----ILEIFNDS--CAGKPNNVSQKYEELKSNTIYPILSTT-------------IVIKALKSIFCIFKIENHMRALPGVDKCSVNLIEEIGMIDYDSGKWNVQKIREEIESLGYLTELPKQNWNSTRQSSAVSLNEESRSKCYLRITGMTCSSCVNKVESHLLKVEGVKSVLVALLAMKCEIIYDSAYVMPFQLSNRVKELGFNAEVIEN 1329
            G  +++V+GMTC SCVR+IEE + +  GV G+ VSL   EA + F+    T ED+  +I++MGFD  + +   ++  +        +  E     S  K+I  +LS  L +  V    E    D+    S+ + E +    +    G   +              PT  V + + GMTC SCV  IE  + ++ G+ SIKV+L++ +     D+++  P ++   I DMGF + +     I E+ + S   +G  +  SQ++    S +  PI                 + +  +    C+  IE ++    G+    V L+     + YD G  +  +I + I  LG+   + +++   + Q   + L+          +TGMTC+SCV+ +ES LL+ +G++   VAL   K  + +DS  V    +   ++ LGF   +I+N
Sbjct:   99 GMVKIQVEGMTCQSCVRSIEEQIGRLEGVIGVQVSLSDKEAILRFNPAKVTPEDMRKRIEDMGFDALILALQGQIQPLSTDWSEVTLGVEGMHCGSCVKNITETLSGMLGVNSVFVSLEKGSVDLRFDPSLLTLETVKGFLEEIPPGNFRVSIPGWSSRLNSASTPTQSVTIGIEGMTCNSCVQAIEGMMSQRAGVCSIKVYLQEKKGIVTFDSTVTCPEELRAEIEDMGFEAWLNQDSEICEVSSVSQMPSGLKHLPSQRHPSKPSPS--PITKENADGTGERELRKCFVHVTGMTCASCVSNIERNLVKHEGIKSVLVALMAGKAEVKYDPGLLDPAQIVQLISHLGFGASVMEEH---SVQDGVLDLS----------VTGMTCASCVHNIESKLLRTKGIQEASVALATNKAHVKFDSDLVGSRDIVRIIEGLGFGVSLIKN 529          

Query:  562 VIVRVNGMTCQSCVDNIESTVGKKQGIISIKVFLEKSEAHALVDASLAGP-DVEEMINDMGFNSEMILEIFNDSCAGKPNNVSQKYEELKSNTIYPILSTTIVIKALKSIFCIFKIENHMRALPGVDKCSVNLIEEIGMID--YDSGKWNVQKIREEIESLGYLTELPKQNWNSTRQSSAVSLNEES--RSKCYLRITGMTCSSCVNKVESHLLKVEGVKSVLVALLAMKCEIIYDSAYVMPFQLSNRVKELGFNA------EVIE-----------------------------------NGNEGIGIVNVLIRGMTCSSCVNHIENHISKIKGIASINVSLSTSKGKVEYFISECGPRDVIDAINDMGFDASLCDHLESNHAAADHI 1590
            V ++V GMTCQSCV +IE  +G+ +G+I ++V L   EA    + +   P D+ + I DMGF++ +IL +      G+   +S  + E+           T+ ++ +    C+  I   +  + GV+   V+L  E G +D  +D     ++ ++      G+L E+P  N+  +    +  LN  S       + I GMTC+SCV  +E  + +  GV S+ V L   K  + +DS    P +L   ++++GF A      E+ E                                    G   +    V + GMTC+SCV++IE ++ K +GI S+ V+L   K +V+Y      P  ++  I+ +GF AS+ +     H+  D +
Sbjct:  101 VKIQVEGMTCQSCVRSIEEQIGRLEGVIGVQVSLSDKEAILRFNPAKVTPEDMRKRIEDMGFDA-LILAL-----QGQIQPLSTDWSEV-----------TLGVEGMHCGSCVKNITETLSGMLGVNSVFVSL--EKGSVDLRFDPSLLTLETVK------GFLEEIPPGNFRVSIPGWSSRLNSASTPTQSVTIGIEGMTCNSCVQAIEGMMSQRAGVCSIKVYLQEKKGIVTFDSTVTCPEELRAEIEDMGFEAWLNQDSEICEVSSVSQMPSGLKHLPSQRHPSKPSPSPITKENADGTGERELRKCFVHVTGMTCASCVSNIERNLVKHEGIKSVLVALMAGKAEVKYDPGLLDPAQIVQLISHLGFGASVME----EHSVQDGV 460          

Query: 1345 GIVNVLIRGMTCSSCVNHIENHISKIKGIASINVSLSTSKGKVEYFISECGPRDVIDAINDMGFDA 1542
            G+V + + GMTC SCV  IE  I +++G+  + VSLS  +  + +  ++  P D+   I DMGFDA
Sbjct:   99 GMVKIQVEGMTCQSCVRSIEEQIGRLEGVIGVQVSLSDKEAILRFNPAKVTPEDMRKRIEDMGFDA 164          

Query:  100 GSARMKVDGMTCMSCVRNIEENLMKFTGVCGIMVSLLHAEATVIFDADIATVEDISNKIDEMGFDVT-VKSSEVSNVKDKVVRSRIK 357
            G   + V GMTC SCV NIE  L++  G+    V+L   +A V FD+D+    DI   I+ +GF V+ +K+  ++N  D     R K
Sbjct:  459 GVLDLSVTGMTCASCVHNIESKLLRTKGIQEASVALATNKAHVKFDSDLVGSRDIVRIIEGLGFGVSLIKNEGLNNTLDHQEEIRWK 545          

Query:  103 SARMKVDGMTCMSCVRNIEENLMKFTGVCGIMVSLLHAEATVIFDADIATVEDISNKIDEMGFDVTVKSSEVSNVKDKVVRSRIKFESDINKSVEKSIETSLSSKLLLVRFCQENNYADIWHYSSIRSTEILSVIQQSEIYGVLVLEQCP---TIRVIVRVNGMTCQSCVDNIESTVGKKQGIISIKVFLEKSEAHALVDA-SLAGPDVEEMINDMGFNSEMILEIFNDSCAGKPNNVSQKYEELKSNTIYPILSTT-IVIKALKSIFCIFKIENHMRALPGVDKCSVNLIEEIGMIDYDSGKWNVQKIREEIESLGYLTELPKQN----------------WNSTRQSSAVSLNEESR---------SKCYLRITGMTCSSCVNKVESHLLKVEGVKSVLVALLAMKCEIIYDSAYVMPFQLSNRVKELGFNAEVIENGNEGIGIVNVLIRGMTCSSCVNHIENHISKIKGIASINVSLSTSKGKVEYFISECGPRDVIDAINDMGFDASLCDHLESNHAAADHINQMIKQWRSSFFFSLICGIPXXXXXXXXXXXXXXXXHTIIHENGS--NRTIMKSTVPM---VCSGLSADNLILFVLATPVQFYGARYFYIQAYLSLKHKTTNMDVLVVMATXXXXXXXXXXXXXXMAFRRNTSPKTFFETSPMLIVFLSLGRWLEHIAKGKTSEALTKLMSLQAVEATLYTPEN-----KERKIPINLVQRNDLIKILPGEKIPVDGKVVTGTSTCDESLITGESMPIEKTHGSDVIGGSINKSGMLIVKATHVGSDSALAQIVKLVEEAQTSKAPIQQLADRIAGMFVPSVLICAIITLIIWVIVGFSKPEI----LPKYVNELSVTEITWEHAFQLAITVLSIACPCSLGLXXXXXXXXXXXXXXXNGILIKGGEPLENIHKLNVIVFDKTGTITNGSPSVTRFLVLIGNGVREHIDKLLKILAAAESASEHPIGKAIITFSKARISNENLPEVLESSAVSGCGLGCKLNLDPKTEVTKFVKNLINIESPSEETNILGQXXXXXXXXXXXXTYKDVIF-PVRQHMAWTSDLCQTVTVIIGNRNWMLRNGILVDDEVDELMSEDENLGRTVILMAIDNELIAMISVADQVKREAALAVYTLKKMNIEVYLMTGDNSKTATAIA------------------RQVGIHYVFAEVLPSHKVAKVQQLQNTNRSLTSKRKMKVAMVGDGINDSPALAQSDVGIAIGTGTDVAVEAADVVLIRNSLLDVIAAIQLSKATVKRIRQNFIAATLYNLLGIPIAAGVLMPIGIEMMPWMXXXXXXXXXXXXXXXXXXXXXWKKPSEEKL 3930
            + +M+++GM C+SC   IE  + K  GV  I VSL   EA V++   I TV++I  +I+  GF  TV                        KS  + ++ S S                           +LS  +Q+E      L + P   T+  + +V GM C SCV NI+  + K   + S+ V LE  +A    +   ++  ++++ I  +   +      F       P          +   + P++S   I I+ +    C+  IE  +    GV    V+L    G  +YD    + +++R  IE +G+   LP+ N                 + +   SAV  NE            SKC+++I GMTC+SCV  +E +L    G+ SVLVAL+A K E+ Y  + + P +++  ++ELGF A V++N +   G + +++RGMTC+SCV+ IE+++ K KGI   +V+LST+K  ++Y     GPRD+I  I +MGF ASL    +   +  DH ++ I+QW+ SF  SL   +P M +M++ +    M+     H N +  +R    ST+ +   +  GLS  NLI F+   PVQF G RYFY QAY ++KH+T NMDVL+V+AT+I++ YSV+V++++M  R   +P TFF+T PML VF+SLGRWLE IAK KTSEAL+KLMSLQA EAT+ T         E ++ + LVQR D++K++PG K PVDG+V+ G S  DESLITGE+MP+ K  GS VI GSIN++G L++KATHVG+D+ L+QIVKLVEEAQTSKAPIQQ AD+I+  FVP +++ +++TL+ W+I+GF    +     P Y   +S  E     AFQ +ITVL IACPCSLGLATPTAVMVGTGVGA NGILIKGGEPLE  HK+  +VFDKTGTIT G+P V + + ++  G R    KLL I+  AE++SEHP+G AI  + K  +  E+L    +  AV GCG+ C   L   TE      NL+  E    E N     +    +     T   +I  P    +  T+    + TV+IGNR WM RN + V  +VDE M+E E  G T +L+A+DNEL AM+++AD VK EA LAV+ L  M +EV LMTGDNSKTA AIA                  R VGI  VFAEVLPSHKVAKV+QLQ   +        +VAMVGDG+NDSPALA +DVGIAIGTGTDVA+EAADVVLIRN LLDV+ +I LSK TVKRIR NF+ A +YNL+GIPIAAGV MP+G+ + PWM SAAMA SSVSVV  SLLLK + KP+ EKL
Sbjct:  172 AVKMRIEGMVCLSCTTTIEGKIGKLKGVEKIKVSLESQEAAVVYLPYIITVDEIVKQIEVAGFKATV------------------------KSKPRQLKLSAS-----------------------EVERLLSAPKQTEEK----LSEPPADSTVTTLFQVTGMHCNSCVVNIQDNISKLPAVTSVVVSLENRQASIQHNPKQVSAVELQKAIEALPPGN------FKAIIPASP----------EPGFLQPLVSVAEIHIEGMTCGSCVQSIEGTLSQKKGVRSAQVSLANHKGTFEYDPLLTSPEELRAAIEDMGFDAFLPETNSLVPSVVKSPSLSVRSSSLSPVRSAVKENEAESDAEPSTNTISKCFIQIGGMTCASCVANIERNLKNEYGIHSVLVALMASKAEVRYSPSVIDPLRIAELIRELGFTATVMDNYDGSDGSLELVVRGMTCASCVHKIESNLMKQKGILYASVALSTNKAHIKYDPEVTGPRDIIRLIENMGFTASLVKK-DRPGSHLDH-SREIRQWKRSFQISLFFCVPVMGMMIYMIVVDHMIDKYHQHHNATAEDRAKYHSTMFLEKQLLPGLSIMNLISFLFCVPVQFIGGRYFYCQAYKAVKHRTANMDVLIVLATTIAFTYSVVVLLVAMVERAKVNPITFFDTPPMLFVFISLGRWLEQIAKSKTSEALSKLMSLQATEATVVTLNEDMSVLSEEQVDVELVQRGDVVKVVPGGKFPVDGRVIEGHSMADESLITGEAMPVTKKPGSTVIAGSINQNGSLLIKATHVGTDTTLSQIVKLVEEAQTSKAPIQQFADKISSYFVPFIVVISVLTLLAWIIIGFVNFSLVQTYFPGYDKSISEAEAVIRFAFQASITVLCIACPCSLGLATPTAVMVGTGVGAQNGILIKGGEPLEMAHKIQSVVFDKTGTITYGAPKVVQ-VKMLAEGNRLPRSKLLAIVGTAENSSEHPLGAAITKYCKQELGTESLGTCTDFQAVPGCGIRC---LVSNTE------NLLKREDSDSEENQHNAVLIQISDARAHSTEHPLIMDPQPLTVVQTA----SYTVLIGNREWMRRNALQVRADVDEAMTEHERRGCTAVLVAVDNELCAMVAIADTVKPEAELAVHVLSAMGLEVVLMTGDNSKTARAIAAQVKNHLILPQNAPILLFRMVGIRKVFAEVLPSHKVAKVEQLQQEGK--------RVAMVGDGVNDSPALAMADVGIAIGTGTDVAIEAADVVLIRNDLLDVVGSIDLSKKTVKRIRINFVFALMYNLVGIPIAAGVFMPVGLVLQPWMGSAAMALSSVSVVLSSLLLKCYTKPTVEKL 1419          

Query:   79 LAIRMKLGSARMKVDGMTCMSCVRNIEENLMKFTGVCGIMVSLLHAEATVIFDADIATVEDISNKIDEMGFDVTVKSSEVSNVKDKVVRSRIKFESDINKSVEKSIETSLSSKLLLVRFCQENNYADIWHYSSIRSTEILSVIQQSEIYGVLVLEQC--PTIR---------------VIVRVNGMTCQSCVDNIESTVGKKQGIISIKVFLEKSEAHALVDASLAGPDVEEMINDMGFNSEMILEIFNDSCAGKPNNV--------------SQKYEELKSNTIYPILSTTIVIKALKSIFCIFKIENHMRALPGVDKCSVNLIEEIGMIDYDSGKWNVQKIREEIESLGYLTELPKQNWNSTRQSSA-VSLNEESRSKCYLRITGMTCSSCVNKVESHLLKVEGVKSVLVALLAMKCEIIYDSAYVMPFQLSNRVKELGFNA------------------------------EVIENGNEG--------IGIVNVLIRGMTCSSCVNHIENHISKIKGIASINVSLSTSKGKVEYFISECGPRDVIDAINDMGFDASLCDHLESN 1569
            +A+   L    + V+GMTC SCV++IE  +    GV  I VSL    ATV +D    T + I++ I++MGF+     S ++N     V++  K  S    S + S++ +LS+   +    +    AD    +      ++S  Q  E+   L  +    P +                V +R+ GM C SC   IE  +GK +G+  IKV LE  EA  +    +    V+E++  +          F  +   KP  +               Q  E+L        ++T   +  +    C+  I++++  LP V    V+L      I ++  + +  ++++ IE+      LP  N+ +   +S      +   S   + I GMTC SCV  +E  L + +GV+S  V+L   K    YD     P +L   ++++GF+A                               V EN  E         I    + I GMTC+SCV +IE ++    GI S+ V+L  SK +V Y  S   P  + + I ++GF A++ D+ + +
Sbjct:    1 MALSTNLCRVTLGVEGMTCGSCVQSIEGRIGGLPGVIHIQVSLEQNNATVTYDHTQHTPQSIADAIEDMGFE-----SSLTNATSTPVQTETKVFSKAGCSAD-SVQQALSTLAQIKGVIETQESADNQGLAVTFVPSLVSEDQLGEVLKCLAPDTACRPPLSPKEGSTSRSFSGVEAVKMRIEGMVCLSCTTTIEGKIGKLKGVEKIKVSLESQEAAVVYLPYII--TVDEIVKQIEVAG------FKATVKSKPRQLKLSASEVERLLSAPKQTEEKLSEPPADSTVTTLFQVTGMHCNSCVVNIQDNISKLPAVTSVVVSLENRQASIQHNPKQVSAVELQKAIEA------LPPGNFKAIIPASPEPGFLQPLVSVAEIHIEGMTCGSCVQSIEGTLSQKKGVRSAQVSLANHKGTFEYDPLLTSPEELRAAIEDMGFDAFLPETNSLVPSVVKSPSLSVRSSSLSPVRSAVKENEAESDAEPSTNTISKCFIQIGGMTCASCVANIERNLKNEYGIHSVLVALMASKAEVRYSPSVIDPLRIAELIRELGFTATVMDNYDGS 547          

Query:  100 GSARMKVDGMTCMSCVRNIEENLMKFTGVCGIMVSLLHAEATVIFDADIATVEDISNKIDEMGFDVTV 303
            GS  + V GMTC SCV  IE NLMK  G+    V+L   +A + +D ++    DI   I+ MGF  ++
Sbjct:  549 GSLELVVRGMTCASCVHKIESNLMKQKGILYASVALSTNKAHIKYDPEVTGPRDIIRLIENMGFTASL 616          

Query:  103 SARMKVDGMTCMSCVRNIEENLMKFTGVCGIMVSLLHAEATVIFDADIATVEDISNKIDEMGFDVTVKSSEVSNVKDKVVRSRIKFESDINKSVEKSIETSLSSKLLLVRFCQENNYADIWHYSSIRSTEILSVIQQSEIYGVLVLEQCP---TIRVIVRVNGMTCQSCVDNIESTVGKKQGIISIKVFLEKSEAHALVDA-SLAGPDVEEMINDMGFNSEMILEIFNDSCAGKPNNVSQKYEELKSNTIYPILSTT-IVIKALKSIFCIFKIENHMRALPGVDKCSVNLIEEIGMIDYDSGKWNVQKIREEIESLGYLTELPKQN----------------WNSTRQSSAVSLNEESR---------SKCYLRITGMTCSSCVNKVESHLLKVEGVKSVLVALLAMKCEIIYDSAYVMPFQLSNRVKELGFNAEVIENGNEGIGIVNVLIRGMTCSSCVNHIENHISKIKGIASINVSLSTSKGKVEYFISECGPRDVIDAINDMGFDASLCDHLESNHAAADHINQMIKQWRSSFFFSLICGIPXXXXXXXXXXXXXXXXHTIIHENGS--NRTIMKSTV---PMVCSGLSADNLILFVLATPVQFYGARYFYIQAYLSLKHKTTNMDVLVVMATXXXXXXXXXXXXXXMAFRRNTSPKTFFETSPMLIVFLSLGRWLEHIAKGKTSEALTKLMSLQAVEATLYTPEN-----KERKIPINLVQRNDLIKILPGEKIPVDGKVVTGTSTCDESLITGESMPIEKTHGSDVIGGSINKSGMLIVKATHVGSDSALAQIVKLVEEAQTSKAPIQQLADRIAGMFVPSVLICAIITLIIWVIVGFSKPEILPKYVNELSVTEITWEHAFQLAITVLSIACPCSLGLXXXXXXXXXXXXXXXNGILIKGGEPLENIHKLNVIVFDKTGTITNGSPSVTRFLVLIGNGVREHIDKLLKILAAAESASEHPIGKAIITFSKARISNENLPEVLESSAVSGCGLGCKLNLDPKTEVTKFVKNLINIESPSEETNILGQXXXXXXXXXXXXTYKDVIF-PVRQHMAWTSDLCQTVTVIIGNRNWMLRNGILVDDEVDELMSEDENLGRTVILMAIDNELIAMISVADQVKREAALAVYTLKKMNIEVYLMTGDNSKTATAIARQVGIHYVFAEVLPSHKVAKVQQLQNTNRSLTSKRKMKVAMVGDGINDSPALAQSDVGIAIGTGTDVAVEAADVVLIRNSLLDVIAAIQLSKATVKRIRQNFIAATLYNLLGIPIAAGVLMPIGIEMMPWMXXXXXXXXXXXXXXXXXXXXXWKKPSEEKL 3930
            + +M+++GM C+SC   IE  + K  GV  I VSL   EA V++   I TV++I  +I+  GF  TV                        KS  + ++ S S                           +LS  +Q+E      L + P   T+  + +V GM C SCV NI+  + K   + S+ V LE  +A    +   ++  ++++ I  +   +      F       P          +   + P++S   I I+ +    C+  IE  +    GV    V+L    G  +YD    + +++R  IE +G+   LP+ N                 + +   SAV  NE            SKC+++I GMTC+SCV  +E +L    G+ SVLVAL+A K E+ Y  + + P +++  ++ELGF A V++N +   G + +++RGMTC+SCV+ IE+++ K KGI   +V+LST+K  ++Y     GPRD+I  I +MGF ASL    +   +  DH ++ I+QW+ SF  SL   +P M +M++ +    M+     H N +  +R    ST+     +  GLS  NLI F+   PVQF G RYFY QAY ++KH+T NMDVL+V+AT+I++ YSV+V++++M  R   +P TFF+T PML VF+SLGRWLE IAK KTSEAL+KLMSLQA EAT+ T         E ++ + LVQR D++K++PG K PVDG+V+ G S  DESLITGE+MP+ K  GS VI GSIN++G L++KATHVG+D+ L+QIVKLVEEAQTSK                                          Y   +S  E     AFQ +ITVL IACPCSLGLATPTAVMVGTGVGA NGILIKGGEPLE  HK+  +VFDKTGTIT G+P V + + ++  G R    KLL I+  AE++SEHP+G AI  + K  +  E+L    +  AV GCG+ C   L   TE      NL+  E    E N     +    +     T   +I  P    +  T+    + TV+IGNR WM RN + V  +VDE M+E E  G T +L+A+DNEL AM+++AD VK EA LAV+ L  M +EV LMTGDNSKTA AIA QVGI  VFAEVLPSHKVAKV+QLQ   +        +VAMVGDG+NDSPALA +DVGIAIGTGTDVA+EAADVVLIRN LLDV+ +I LSK TVKRIR NF+ A +YNL+GIPIAAGV MP+G+ + PWM SAAMA SSVSVV  SLLLK + KP+ EKL
Sbjct:  172 AVKMRIEGMVCLSCTTTIEGKIGKLKGVEKIKVSLESQEAAVVYLPYIITVDEIVKQIEVAGFKATV------------------------KSKPRQLKLSAS-----------------------EVERLLSAPKQTEEK----LSEPPADSTVTTLFQVTGMHCNSCVVNIQDNISKLPAVTSVVVSLENRQASIQHNPKQVSAVELQKAIEALPPGN------FKAIIPASP----------EPGFLQPLVSVAEIHIEGMTCGSCVQSIEGTLSQKKGVRSAQVSLANHKGTFEYDPLLTSPEELRAAIEDMGFDAFLPETNSLVPSVVKSPSLSVRSSSLSPVRSAVKENEAESDAEPSTNTISKCFIQIGGMTCASCVANIERNLKNEYGIHSVLVALMASKAEVRYSPSVIDPLRIAELIRELGFTATVMDNYDGSDGSLELVVRGMTCASCVHKIESNLMKQKGILYASVALSTNKAHIKYDPEVTGPRDIIRLIENMGFTASLVKK-DRPGSHLDH-SREIRQWKRSFQISLFFCVPVMGMMIYMIVVDHMIDKYHQHHNATAEDRAKYHSTMFLEKQLLPGLSIMNLISFLFCVPVQFIGGRYFYCQAYKAVKHRTANMDVLIVLATTIAFTYSVVVLLVAMVERAKVNPITFFDTPPMLFVFISLGRWLEQIAKSKTSEALSKLMSLQATEATVVTLNEDMSVLSEEQVDVELVQRGDVVKVVPGGKFPVDGRVIEGHSMADESLITGEAMPVTKKPGSTVIAGSINQNGSLLIKATHVGTDTTLSQIVKLVEEAQTSKG-----------------------------------------YDKSISEAEAVIRFAFQASITVLCIACPCSLGLATPTAVMVGTGVGAQNGILIKGGEPLEMAHKIQSVVFDKTGTITYGAPKVVQ-VKMLAEGNRLPRSKLLAIVGTAENSSEHPLGAAITKYCKQELGTESLGTCTDFQAVPGCGIRC---LVSNTE------NLLKREDSDSEENQHNAVLIQISDARAHSTEHPLIMDPQPLTVVQTA----SYTVLIGNREWMRRNALQVRADVDEAMTEHERRGCTAVLVAVDNELCAMVAIADTVKPEAELAVHVLSAMGLEVVLMTGDNSKTARAIAAQVGIRKVFAEVLPSHKVAKVEQLQQEGK--------RVAMVGDGVNDSPALAMADVGIAIGTGTDVAIEAADVVLIRNDLLDVVGSIDLSKKTVKRIRINFVFALMYNLVGIPIAAGVFMPVGLVLQPWMGSAAMALSSVSVVLSSLLLKCYTKPTVEKL 1356          

Query:   79 LAIRMKLGSARMKVDGMTCMSCVRNIEENLMKFTGVCGIMVSLLHAEATVIFDADIATVEDISNKIDEMGFDVTVKSSEVSNVKDKVVRSRIKFESDINKSVEKSIETSLSSKLLLVRFCQENNYADIWHYSSIRSTEILSVIQQSEIYGVLVLEQC--PTIR---------------VIVRVNGMTCQSCVDNIESTVGKKQGIISIKVFLEKSEAHALVDASLAGPDVEEMINDMGFNSEMILEIFNDSCAGKPNNV--------------SQKYEELKSNTIYPILSTTIVIKALKSIFCIFKIENHMRALPGVDKCSVNLIEEIGMIDYDSGKWNVQKIREEIESLGYLTELPKQNWNSTRQSSA-VSLNEESRSKCYLRITGMTCSSCVNKVESHLLKVEGVKSVLVALLAMKCEIIYDSAYVMPFQLSNRVKELGFNA------------------------------EVIENGNEG--------IGIVNVLIRGMTCSSCVNHIENHISKIKGIASINVSLSTSKGKVEYFISECGPRDVIDAINDMGFDASLCDHLESN 1569
            +A+   L    + V+GMTC SCV++IE  +    GV  I VSL    ATV +D    T + I++ I++MGF+     S ++N     V++  K  S    S + S++ +LS+   +    +    AD    +      ++S  Q  E+   L  +    P +                V +R+ GM C SC   IE  +GK +G+  IKV LE  EA  +    +    V+E++  +          F  +   KP  +               Q  E+L        ++T   +  +    C+  I++++  LP V    V+L      I ++  + +  ++++ IE+      LP  N+ +   +S      +   S   + I GMTC SCV  +E  L + +GV+S  V+L   K    YD     P +L   ++++GF+A                               V EN  E         I    + I GMTC+SCV +IE ++    GI S+ V+L  SK +V Y  S   P  + + I ++GF A++ D+ + +
Sbjct:    1 MALSTNLCRVTLGVEGMTCGSCVQSIEGRIGGLPGVIHIQVSLEQNNATVTYDHTQHTPQSIADAIEDMGFE-----SSLTNATSTPVQTETKVFSKAGCSAD-SVQQALSTLAQIKGVIETQESADNQGLAVTFVPSLVSEDQLGEVLKCLAPDTACRPPLSPKEGSTSRSFSGVEAVKMRIEGMVCLSCTTTIEGKIGKLKGVEKIKVSLESQEAAVVYLPYII--TVDEIVKQIEVAG------FKATVKSKPRQLKLSASEVERLLSAPKQTEEKLSEPPADSTVTTLFQVTGMHCNSCVVNIQDNISKLPAVTSVVVSLENRQASIQHNPKQVSAVELQKAIEA------LPPGNFKAIIPASPEPGFLQPLVSVAEIHIEGMTCGSCVQSIEGTLSQKKGVRSAQVSLANHKGTFEYDPLLTSPEELRAAIEDMGFDAFLPETNSLVPSVVKSPSLSVRSSSLSPVRSAVKENEAESDAEPSTNTISKCFIQIGGMTCASCVANIERNLKNEYGIHSVLVALMASKAEVRYSPSVIDPLRIAELIRELGFTATVMDNYDGS 547          

Query:  100 GSARMKVDGMTCMSCVRNIEENLMKFTGVCGIMVSLLHAEATVIFDADIATVEDISNKIDEMGFDVTV 303
            GS  + V GMTC SCV  IE NLMK  G+    V+L   +A + +D ++    DI   I+ MGF  ++
Sbjct:  549 GSLELVVRGMTCASCVHKIESNLMKQKGILYASVALSTNKAHIKYDPEVTGPRDIIRLIENMGFTASL 616          

Query:  109 RMKVDGMTCMSCVRNIEENLMKFTGVCGIMVSLLHAEATVIFDADIATVEDISNKIDEMGFDVTVKSSEVSNVKDKVVRSRIKFESDINKSVEKSIETSLSSKLLLVRFCQENNYADIWHYSSIRSTEILSVIQQSEIYGVLVLEQCPTIRVIVRVNGMTCQSCVDNIESTVGKKQGIISIKVFLEKSEA----HALVDASLAGPDVEEMINDMGF-----NSEMILEIFNDSCAGKPNNVSQKYEELKSNTIYPILSTTIVIKALKSIFCIFKIENHMRALPGVDKCSVNLIEEIGMIDYDSGKWNVQKIREEIESLGYLTELPKQNWNSTRQSSAVSLNEESRS--KCYLRITGMTCSSCVNKVESHLLKVEGVKSVLVALLAMKCEIIYDSAYVMPFQLSNRVKELGFNAEVIENGNEGIGIVNVLIRGMTCSSCVNHIENHISKIKGIASINVSLSTSKGKVEYFISECGPRDVIDAINDMGFDASLCDHLESNHAAADHINQM--IKQWRSSFFFSLICGIPXXXXXXXXXXXXXXXXHTII--HENGSNRTIMKSTVPMVCS-----GLSADNLILFVLATPVQFYGARYFYIQAYLSLKHKTTNMDVLVVMATXXXXXXXXXXXXXXMAFRRNTSPKTFFETSPMLIVFLSLGRWLEHIAKGKTSEALTKLMSLQAVEAT--LYTPEN---KERKIPINLVQRNDLIKILPGEKIPVDGKVVTGTSTCDESLITGESMPIEKTHGSDVIGGSINKSGMLIVKATHVGSDSALAQIVKLVEEAQTSKAPIQQLADRIAGMFVPSVLICAIITLIIWVIVGFSKPEI----LPKYVNELSVTEITWEHAFQLAITVLSIACPCSLGLXXXXXXXXXXXXXXXNGILIKGGEPLENIHKLNVIVFDKTGTITNGSPSVTRFLVLIGNGVREHIDKLLKILAAAESASEHPIGKAIITFSKARISNENLPEVLESSAVSGCGLGCKL-NLDPKTEVTKFVKNLINIESPSEETNILGQXXXXXXXXXXXXTYKDVIFP-VRQHMAWTSDLCQTVTVIIGNRNWMLRNGILVDDEVDELMSEDENLGRTVILMAIDNELIAMISVADQVKREAALAVYTLKKMNIEVYLMTGDNSKTATAIARQVGIHYVFAEVLPSHKVAKVQQLQNTNRSLTSKRKMKVAMVGDGINDSPALAQSDVGIAIGTGTDVAVEAADVVLIRNSLLDVIAAIQLSKATVKRIRQNFIAATLYNLLGIPIAAGVLMPIGIEMMPWMXXXXXXXXXXXXXXXXXXXXXWKKPSEEKL 3930
            +MK++GMTC SC   IE  + K  GV  I VSL   EA +++   +   EDI  +I+E GF        ++ +K K  +     +      +E+   T            Q N+  D+         ++                    IR I ++ GM C+SCV NIES +G + G+ SI+V LE   A    ++ +  S A     E ++   F     N   + E F+     + +   + +    SN  +    T I I+ +  + C+  IE  +   PGV    V+L+   G + YD    + + IR  IE +G+   L       T + + V    E R+  KC+++ITGMTC+SCV  +E +L + EG+ SVLVAL+A K E+ Y+   + P  ++  ++ELGF A V+EN ++G GI+ +L+RGMTC+SCV+ IE+ + K KG+   +V+L+T+K  +++     GPRD++  IND+GF  SL     S    A H++    I++W+ SF  SLI  IP M +M+  MF      H ++  H N +   I      MV       GLS  NL+  +L  PVQF G  YFYIQAY +LKH+T NMDVL+V+ATS+++IYS+IV+++++  +   +P TFF+T PML VF++LGRWLEHIAK KTSEAL++L+SLQA EAT  +  P+N    E ++ + LVQR D++++ PG K PVDG+V+ G S  DESLITGE+MP+ K  GS VI GSIN++G L++ ATHVGSD+ L+QIVKLVE+AQTSKAPIQQ AD+++G FVP ++  +++TL +W+I+G+   EI     P Y   +S  E+    AFQ AITVL IACPCSLGLATPTAVMVGTGVGA NGILIKGGEPLE  HK+  +VFDKTGTIT G+P V +  VL+ +  R   +KLL I+  AES SEHP+G A+I + K  ++ E L    +  AV GCG+ CK+ N++P         N  N    +    I GQ             ++D I P +      +S   QT +V+IGNR WM RN + +  E D LM+E E  GRT +L+A+D  L  +I++AD VK EAALA+++L+ M +++ LMTGDNSKTA  IA QVGI  VFAEVLPSHKVAKV+QLQ        ++  +VAMVGDGINDSPALA +DVGI IG+GTDVA+EAADVVLIRN LLDV+A+I LS+ TVKRIR NF+ A +YNL+GIPIAAGV MP+G+ + PWM SAAMAASSVSVV  SLLLKL++KPS EKL
Sbjct:  168 KMKIEGMTCHSCTSTIEGKVGKLKGVQRIKVSLDSQEAQILYQPHLIKPEDIRTQIEEAGF--------IAQIKSKPPQKLGAID------IERLTNT------------QTNSNGDLPQKIPKHQNDL--------------------IRAIFQIEGMHCKSCVVNIESNIGSQHGVSSIEVSLENKLAVIHFYSNITTSDALIQAIEALSPGTFKVSLCNHPELAETFSMQKNSEASCAKEIFSS-PSNQDFCSKVTVINIEGMTCMSCVQSIEGLISKKPGVKSIQVSLVNNNGTVQYDPAVTSPEDIRAAIEDMGFDASL----LERTNKETPVHSKPEKRTVNKCFIQITGMTCASCVANIERNLRREEGIYSVLVALMAGKAEVRYNPEVLQPSGIAELIQELGFEASVLENYDDGTGILELLVRGMTCASCVHKIESRLMKTKGVLYSSVALATNKAHIKFDPEVIGPRDIMKIINDLGFSTSLVKKDRS----ASHLDHRVEIQRWKRSFLISLIFCIPVMGLMVHMMFMEN---HYLMPHHHNMTMEDIASYHPTMVLEYQIIPGLSIMNLVSLLLCIPVQFLGGWYFYIQAYKALKHRTANMDVLIVLATSVAFIYSLIVLIVAIFEKSKVNPITFFDTPPMLFVFIALGRWLEHIAKSKTSEALSRLISLQATEATVVILDPDNTVKSEEQVDVELVQRGDIVRVTPGGKFPVDGRVIEGQSMVDESLITGEAMPVSKKPGSSVIAGSINQNGSLLIAATHVGSDTTLSQIVKLVEDAQTSKAPIQQFADKLSGYFVPFIVAVSVLTLFVWIIIGYHNFEIVEKYFPGYNKSISKGEVIVRFAFQAAITVLCIACPCSLGLATPTAVMVGTGVGAQNGILIKGGEPLEMAHKVKTVVFDKTGTITKGTPVVMQVKVLVESN-RMPSNKLLAIVGTAESNSEHPLGSAVIKYCKEVLNAETLGTCYDFQAVPGCGISCKVNNIEPLLHAANGPDNKRN----AVLVQIDGQ-------------HEDSILPSITVSQNPSSSPPQTYSVLIGNREWMNRNFLTLTAETDSLMTEHEKKGRTAVLVAVDGVLCGLIAIADTVKPEAALAIHSLRSMGLDIVLMTGDNSKTAKTIAAQVGITKVFAEVLPSHKVAKVKQLQ--------EQGTRVAMVGDGINDSPALAMADVGITIGSGTDVAIEAADVVLIRNDLLDVVASIDLSRKTVKRIRINFVFALIYNLVGIPIAAGVFMPVGLILQPWMGSAAMAASSVSVVFSSLLLKLYRKPSREKL 1388          

Query:  106 ARMKVDGMTCMSCVRNIEENLMKFTGVCGIMVSLLHAEATVIFDADIATVEDISNKIDEMGFDVTVKSSEVSNVKDKVVRSRIKFES---DINKSVEK-----SIETSLSSKLLLVRFCQENNYADIWHYSSIRSTEILSVIQQSEIYGVLVLEQCPTIRVIV--RVNGMTCQSCVDNIESTVGKKQGIISIKVFLEKSEAHALVDASLAGP-DVEEMINDMGFNSEMI-----------LEIFNDSCAGKPNNVSQKYEELKSNTIYPILSTTIVIKALKSIFCIFKIENHMRALPGVDKCSVNLIEEIGMIDYDSGKWNVQKIREEIESLGYLTELPKQNWNSTRQSSAVSLNEESRSKC------------------YLRITGMTCSSCVNKVESHLLKVEGVKSVLVALLAMKCEIIYDSAYVMPFQLSNRVKELGFNAEVIENGNEGIGI--------VN---VLIRGMTCSSCVNHIENHISKIKGIASINVSLSTSKGKVEYFISECGPRDVIDAINDMGFDASLCDHLE 1563
            A + V+GMTC SCV+ IE+ +    GV  I VSL    A +I+DA + T + +   +++MGF+ T+  +    V       R+  E     I   + +      ++TSL  K+  V F        +     I    + S+  +    G +         V+V  ++ GMTC SC   IE  VGK +G+  IKV L+  EA  L    L  P D+   I + GF +++            +E   ++      ++ QK  + +++ I  I      I+ +    C+  IE+++ +  GV    V+L  ++ +I + S       + + IE+L   T       N    +   S+ + S + C                   + I GMTC SCV  +E  + K  GVKS+ V+L+     + YD A   P  +   ++++GF+A ++E  N+   +        VN   + I GMTC+SCV +IE ++ + +GI S+ V+L   K +V Y      P  + + I ++GF+AS+ ++ +
Sbjct:    6 AFIPVEGMTCNSCVQTIEQKIGSINGVHSIKVSLEGKNAAIIYDAKLQTPKALQEAVEDMGFESTLSYANPQPVPMDSTFLRLSAEQSAEQIRSGLSQFKGVLDVKTSLEGKVACVTFIPSVVNPGLL-IQKIPGLSLDSMASKKTTSGSVESRSSVASDVLVKMKIEGMTCHSCTSTIEGKVGKLKGVQRIKVSLDSQEAQILYQPHLIKPEDIRTQIEEAGFIAQIKSKPPQKLGAIDIERLTNTQTNSNGDLPQKIPKHQNDLIRAIFQ----IEGMHCKSCVVNIESNIGSQHGVSSIEVSLENKLAVIHFYSNITTSDALIQAIEALSPGT-FKVSLCNHPELAETFSMQKNSEASCAKEIFSSPSNQDFCSKVTVINIEGMTCMSCVQSIEGLISKKPGVKSIQVSLVNNNGTVQYDPAVTSPEDIRAAIEDMGFDASLLERTNKETPVHSKPEKRTVNKCFIQITGMTCASCVANIERNLRREEGIYSVLVALMAGKAEVRYNPEVLQPSGIAELIQELGFEASVLENYD 536          

Query:  109 RMKVDGMTCMSCVRNIEENLMKFTGVCGIMVSLLHAEATVIFDADIATVEDISNKIDEMGFDVTVKSSEVSNVKDKVVRSRIKFESDINKSVEKSIETSLSSKLLLVRFCQENNYADIWHYSSIRSTEILSVIQQSEIYGVLVLEQCPTIRVIVRVNGMTCQSCVDNIESTVGKKQGIISIKVFLEKSEA----HALVDASLAGPDVEEMINDMGF-----NSEMILEIFNDSCAGKPNNVSQKYEELKSNTIYPILSTTIVIKALKSIFCIFKIENHMRALPGVDKCSVNLIEEIGMIDYDSGKWNVQKIREEIESLGYLTEL------------------PKQNWNSTRQSSAVSLNEESRS--KCYLRITGMTCSSCVNKVESHLLKVEGVKSVLVALLAMKCEIIYDSAYVMPFQLSNRVKELGFNAEVIENGNEGIGIVNVLIRGMTCSSCVNHIENHISKIKGIASINVSLSTSKGKVEYFISECGPRDVIDAINDMGFDASLCDHLESNHAAADHINQM--IKQWRSSFFFSLICGIPXXXXXXXXXXXXXXXXHTII--HENGSNRTIMKSTVPMVCS-----GLSADNLILFVLATPVQFYGARYFYIQAYLSLKHKTTNMDVLVVMATXXXXXXXXXXXXXXMAFRRNTSPKTFFETSPMLIVFLSLGRWLEHIAKGKTSEALTKLMSLQAVEAT--LYTPEN---KERKIPINLVQRNDLIKILPGEKIPVDGKVVTGTSTCDESLITGESMPIEKTHGSDVIGGSINKSGMLIVKATHVGSDSALAQIVKLVEEAQTSKAPIQQLADRIAGMFVPSVLICAIITLIIWVIVGFSKPEI----LPKYVNELSVTEITWEHAFQLAITVLSIACPCSLGLXXXXXXXXXXXXXXXNGILIKGGEPLENIHKLNVIVFDKTGTITNGSPSVTRFLVLIGNGVREHIDKLLKILAAAESASEHPIGKAIITFSKARISNENLPEVLESSAVSGCGLGCKL-NLDPKTEVTKFVKNLINIESPSEETNILGQXXXXXXXXXXXXTYKDVIFP---VRQHMAWTSDLCQTVTVIIGNRNWMLRNGILVDDEVDELMSEDENLGRTVILMAIDNELIAMISVADQVKREAALAVYTLKKMNIEVYLMTGDNSKTATAIARQVGIHYVFAEVLPSHKVAKVQQLQNTNRSLTSKRKMKVAMVGDGINDSPALAQSDVGIAIGTGTDVAVEAADVVLIRNSLLDVIAAIQLSKATVKRIRQNFIAATLYNLLGIPIAAGVLMPIGIEMMPWMXXXXXXXXXXXXXXXXXXXXXWKKPSEEKL 3930
            +MK++GMTC SC   IE  + K  GV  I VSL   EA +++   +   EDI  +I+E GF        ++ +K K  +     +      +E+   T            Q N+  D+         ++                    IR I ++ GM C+SCV NIES +G + G+ SI+V LE   A    ++ +  S A     E ++   F     N   + E F+     + +   + +    SN  +    T I I+ +  + C+  IE  +   PGV    V+L+   G + YD    + + IR  IE +G+   L                  PK+  N   + + V    E R+  KC+++ITGMTC+SCV  +E +L + EG+ SVLVAL+A K E+ Y+   + P  ++  ++ELGF A V+EN ++G GI+ +L+RGMTC+SCV+ IE+ + K KG+   +V+L+T+K  +++     GPRD++  IND+GF  SL     S    A H++    I++W+ SF  SLI  IP M +M+  MF      H ++  H N +   I      MV       GLS  NL+  +L  PVQF G  YFYIQAY +LKH+T NMDVL+V+ATS+++IYS+IV+++++  +   +P TFF+T PML VF++LGRWLEHIAK KTSEAL++L+SLQA EAT  +  P+N    E ++ + LVQR D++++ PG K PVDG+V+ G S  DESLITGE+MP+ K  GS VI GSIN++G L++ ATHVGSD+ L+QIVKLVE+AQTSKAPIQQ AD+++G FVP ++  +++TL +W+I+G+   EI     P Y   +S  E+    AFQ AITVL IACPCSLGLATPTAVMVGTGVGA NGILIKGGEPLE  HK+  +VFDKTGTIT G+P V +  VL+ +  R   +KLL I+  AES SEHP+G A+I + K  ++ E L    +  AV GCG+ CK+ N++P         N  N    +    I GQ             ++D I P   V Q+ +  S   QT +V+IGNR WM RN + +  E D LM+E E  GRT +L+A+D  L  +I++AD VK EAALA+++L+ M +++ LMTGDNSKTA  IA QVGI  VFAEVLPSHKVAKV+QLQ        ++  +VAMVGDGINDSPALA +DVGI IG+GTDVA+EAADVVLIRN LLDV+A+I LS+ TVKRIR NF+ A +YNL+GIPIAAGV MP+G+ + PWM SAAMAASSVSVV  SLLLKL++KPS EKL
Sbjct:  172 KMKIEGMTCHSCTSTIEGKVGKLKGVQRIKVSLDSQEAQILYQPHLIKPEDIRTQIEEAGF--------IAQIKSKPPQKLGAID------IERLTNT------------QTNSNGDLPQKIPKHQNDL--------------------IRAIFQIEGMHCKSCVVNIESNIGSQHGVSSIEVSLENKLAVIHFYSNITTSDALIQAIEALSPGTFKVSLCNHPELAETFSMQKNSEASCAKEIFSS-PSNQDFCSKVTVINIEGMTCMSCVQSIEGLISKKPGVKSIQVSLVNNNGTVQYDPAVTSPEDIRAAIEDMGFDASLLDAFTSEASQKPFLNSLLPKERTN---KETPVHSKPEKRTVNKCFIQITGMTCASCVANIERNLRREEGIYSVLVALMAGKAEVRYNPEVLQPSGIAELIQELGFEASVLENYDDGTGILELLVRGMTCASCVHKIESRLMKTKGVLYSSVALATNKAHIKFDPEVIGPRDIMKIINDLGFSTSLVKKDRS----ASHLDHRVEIQRWKRSFLISLIFCIPVMGLMVHMMFMEN---HYLMPHHHNMTMEDIASYHPTMVLEYQIIPGLSIMNLVSLLLCIPVQFLGGWYFYIQAYKALKHRTANMDVLIVLATSVAFIYSLIVLIVAIFEKSKVNPITFFDTPPMLFVFIALGRWLEHIAKSKTSEALSRLISLQATEATVVILDPDNTVKSEEQVDVELVQRGDIVRVTPGGKFPVDGRVIEGQSMVDESLITGEAMPVSKKPGSSVIAGSINQNGSLLIAATHVGSDTTLSQIVKLVEDAQTSKAPIQQFADKLSGYFVPFIVAVSVLTLFVWIIIGYHNFEIVEKYFPGYNKSISKGEVIVRFAFQAAITVLCIACPCSLGLATPTAVMVGTGVGAQNGILIKGGEPLEMAHKVKTVVFDKTGTITKGTPVVMQVKVLVESN-RMPSNKLLAIVGTAESNSEHPLGSAVIKYCKEVLNAETLGTCYDFQAVPGCGISCKVNNIEPLLHAANGPDNKRN----AVLVQIDGQ-------------HEDSILPSITVSQNPSNGSSPPQTYSVLIGNREWMNRNFLTLTAETDSLMTEHEKKGRTAVLVAVDGVLCGLIAIADTVKPEAALAIHSLRSMGLDIVLMTGDNSKTAKTIAAQVGITKVFAEVLPSHKVAKVKQLQ--------EQGTRVAMVGDGINDSPALAMADVGITIGSGTDVAIEAADVVLIRNDLLDVVASIDLSRKTVKRIRINFVFALIYNLVGIPIAAGVFMPVGLILQPWMGSAAMAASSVSVVFSSLLLKLYRKPSREKL 1413          

Query:  106 ARMKVDGMTCMSCVRNIEENLMKFTGVCGIMVSLLHAEATVIFDADIATVEDISNKIDEMGFDVTVKSSEVSNVKDKVVRSRIKFES---DINKSVEK-----SIETSLSSKLLLVRFCQENNYADIWHYSSIRSTEILSVIQQSEIYGVLVLEQCPTIRVIV--RVNGMTCQSCVDNIESTVGKKQGIISIKVFLEKSEAHALVDASLAGP-DVEEMINDMGFNSEMI-----------LEIFNDSCAGKPNNVSQKYEELKSNTIYPILSTTIVIKALKSIFCIFKIENHMRALPGVDKCSVNLIEEIGMIDYDSGKWNVQKIREEIESLGYLTELPKQNWNSTRQSSAVSLNEESRSKC------------------YLRITGMTCSSCVNKVESHLLKVEGVKSVLVALLAMKCEIIYDSAYVMPFQLSNRVKELGFNAEVI-------------------ENGNEGIGI--------VN---VLIRGMTCSSCVNHIENHISKIKGIASINVSLSTSKGKVEYFISECGPRDVIDAINDMGFDASLCDHLE 1563
            A + V+GMTC SCV+ IE+ +    GV  I VSL    A +I+DA + T + +   +++MGF+ T+  +    V       R+  E     I   + +      ++TSL  K+  V F        +     I    + S+  +    G +         V+V  ++ GMTC SC   IE  VGK +G+  IKV L+  EA  L    L  P D+   I + GF +++            +E   ++      ++ QK  + +++ I  I      I+ +    C+  IE+++ +  GV    V+L  ++ +I + S       + + IE+L   T       N    +   S+ + S + C                   + I GMTC SCV  +E  + K  GVKS+ V+L+     + YD A   P  +   ++++GF+A ++                   E  N+   +        VN   + I GMTC+SCV +IE ++ + +GI S+ V+L   K +V Y      P  + + I ++GF+AS+ ++ +
Sbjct:   10 AFIPVEGMTCNSCVQTIEQKIGSINGVHSIKVSLEGKNAAIIYDAKLQTPKALQEAVEDMGFESTLSYANPQPVPMDSTFLRLSAEQSAEQIRSGLSQFKGVLDVKTSLEGKVACVTFIPSVVNPGLL-IQKIPGLSLDSMASKKTTSGSVESRSSVASDVLVKMKIEGMTCHSCTSTIEGKVGKLKGVQRIKVSLDSQEAQILYQPHLIKPEDIRTQIEEAGFIAQIKSKPPQKLGAIDIERLTNTQTNSNGDLPQKIPKHQNDLIRAIFQ----IEGMHCKSCVVNIESNIGSQHGVSSIEVSLENKLAVIHFYSNITTSDALIQAIEALSPGT-FKVSLCNHPELAETFSMQKNSEASCAKEIFSSPSNQDFCSKVTVINIEGMTCMSCVQSIEGLISKKPGVKSIQVSLVNNNGTVQYDPAVTSPEDIRAAIEDMGFDASLLDAFTSEASQKPFLNSLLPKERTNKETPVHSKPEKRTVNKCFIQITGMTCASCVANIERNLRREEGIYSVLVALMAGKAEVRYNPEVLQPSGIAELIQELGFEASVLENYD 559          

Query: 1339 GIGIVNVLIRGMTCSSCVNHIENHISKIKGIASINVSLSTSKGKVEYFISECGPRDVIDAINDMGFDASL 1548
            G  +  + + GMTC+SCV  IE  I  I G+ SI VSL      + Y      P+ + +A+ DMGF+++L
Sbjct:    6 GAFLAFIPVEGMTCNSCVQTIEQKIGSINGVHSIKVSLEGKNAAIIYDAKLQTPKALQEAVEDMGFESTL 75          

Query:  109 RMKVDGMTCMSCVRNIEENLMKFTGVCGIMVSLLHAEATVIFDADIATVEDISNKIDEMGFDVTVKSSEVSNVKDKVVRSRIKFESDINKSVEKSIETSLSSKLLLVRFCQENNYADIWHYSSIRSTEILSVIQQSEIYGVLVLEQCPTIRVIVRVNGMTCQSCVDNIESTVGKKQGIISIKVFLEKSEA----HALVDASLAGPDVEEMINDMGF-----NSEMILEIFNDSCAGKPNNVSQKYEELKSNTIYPILSTTIVIKALKSIFCIFKIENHMRALPGVDKCSVNLIEEIGMIDYDSGKWNVQKIREEIESLGYLTEL------------------------PKQNWNSTRQSSAVSLNEESRS--KCYLRITGMTCSSCVNKVESHLLKVEGVKSVLVALLAMKCEIIYDSAYVMPFQLSNRVKELGFNAEVIENGNEGIGIVNVLIRGMTCSSCVNHIENHISKIKGIASINVSLSTSKGKVEYFISECGPRDVIDAINDMGFDASLCDHLESNHAAADHINQM--IKQWRSSFFFSLICGIPXXXXXXXXXXXXXXXXHTII--HENGSNRTIMKSTVPMVCS-----GLSADNLILFVLATPVQFYGARYFYIQAYLSLKHKTTNMDVLVVMATXXXXXXXXXXXXXXMAFRRNTSPKTFFETSPMLIVFLSLGRWLEHIAKGKTSEALTKLMSLQAVEAT--LYTPEN---KERKIPINLVQRNDLIKILPGEKIPVDGKVVTGTSTCDESLITGESMPIEKTHGSDVIGGSINKSGMLIVKATHVGSDSALAQIVKLVEEAQTSKAPIQQLADRIAGMFVPSVLICAIITLIIWVIVGFSKPEI----LPKYVNELSVTEITWEHAFQLAITVLSIACPCSLGLXXXXXXXXXXXXXXXNGILIKGGEPLENIHKLNVIVFDKTGTITNGSPSVTRFLVLIGNGVREHIDKLLKILAAAESASEHPIGKAIITFSKARISNENLPEVLESSAVSGCGLGCKL-NLDPKTEVTKFVKNLINIESPSEETNILGQXXXXXXXXXXXXTYKDVIFP---VRQHMAWTSDLCQTVTVIIGNRNWMLRNGILVDDEVDELMSEDENLGRTVILMAIDNELIAMISVADQVKREAALAVYTLKKMNIEVYLMTGDNSKTATAIARQVGIHYVFAEVLPSHKVAKVQQLQNTNRSLTSKRKMKVAMVGDGINDSPALAQSDVGIAIGTGTDVAVEAADVVLIRNSLLDVIAAIQLSKATVKRIRQNFIAATLYNLLGIPIAAGVLMPIGIEMMPWMXXXXXXXXXXXXXXXXXXXXXWKKPSEEKL 3930
            +MK++GMTC SC   IE  + K  GV  I VSL   EA +++   +   EDI  +I+E GF        ++ +K K  +     +      +E+   T            Q N+  D+         ++                    IR I ++ GM C+SCV NIES +G + G+ SI+V LE   A    ++ +  S A     E ++   F     N   + E F+     + +   + +    SN  +    T I I+ +  + C+  IE  +   PGV    V+L+   G + YD    + + IR  IE +G+   L                        PK+  N   + + V    E R+  KC+++ITGMTC+SCV  +E +L + EG+ SVLVAL+A K E+ Y+   + P  ++  ++ELGF A V+EN ++G GI+ +L+RGMTC+SCV+ IE+ + K KG+   +V+L+T+K  +++     GPRD++  IND+GF  SL     S    A H++    I++W+ SF  SLI  IP M +M+  MF      H ++  H N +   I      MV       GLS  NL+  +L  PVQF G  YFYIQAY +LKH+T NMDVL+V+ATS+++IYS+IV+++++  +   +P TFF+T PML VF++LGRWLEHIAK KTSEAL++L+SLQA EAT  +  P+N    E ++ + LVQR D++++ PG K PVDG+V+ G S  DESLITGE+MP+ K  GS VI GSIN++G L++ ATHVGSD+ L+QIVKLVE+AQTSKAPIQQ AD+++G FVP ++  +++TL +W+I+G+   EI     P Y   +S  E+    AFQ AITVL IACPCSLGLATPTAVMVGTGVGA NGILIKGGEPLE  HK+  +VFDKTGTIT G+P V +  VL+ +  R   +KLL I+  AES SEHP+G A+I + K  ++ E L    +  AV GCG+ CK+ N++P         N  N    +    I GQ             ++D I P   V Q+ +  S   QT +V+IGNR WM RN + +  E D LM+E E  GRT +L+A+D  L  +I++AD VK EAALA+++L+ M +++ LMTGDNSKTA  IA QVGI  VFAEVLPSHKVAKV+QLQ        ++  +VAMVGDGINDSPALA +DVGI IG+GTDVA+EAADVVLIRN LLDV+A+I LS+ TVKRIR NF+ A +YNL+GIPIAAGV MP+G+ + PWM SAAMAASSVSVV  SLLLKL++KPS EKL
Sbjct:  172 KMKIEGMTCHSCTSTIEGKVGKLKGVQRIKVSLDSQEAQILYQPHLIKPEDIRTQIEEAGF--------IAQIKSKPPQKLGAID------IERLTNT------------QTNSNGDLPQKIPKHQNDL--------------------IRAIFQIEGMHCKSCVVNIESNIGSQHGVSSIEVSLENKLAVIHFYSNITTSDALIQAIEALSPGTFKVSLCNHPELAETFSMQKNSEASCAKEIFSS-PSNQDFCSKVTVINIEGMTCMSCVQSIEGLISKKPGVKSIQVSLVNNNGTVQYDPAVTSPEDIRAAIEDMGFDASLLANTGQADAFTSEASQKPFLNSLLPKERTN---KETPVHSKPEKRTVNKCFIQITGMTCASCVANIERNLRREEGIYSVLVALMAGKAEVRYNPEVLQPSGIAELIQELGFEASVLENYDDGTGILELLVRGMTCASCVHKIESRLMKTKGVLYSSVALATNKAHIKFDPEVIGPRDIMKIINDLGFSTSLVKKDRS----ASHLDHRVEIQRWKRSFLISLIFCIPVMGLMVHMMFMEN---HYLMPHHHNMTMEDIASYHPTMVLEYQIIPGLSIMNLVSLLLCIPVQFLGGWYFYIQAYKALKHRTANMDVLIVLATSVAFIYSLIVLIVAIFEKSKVNPITFFDTPPMLFVFIALGRWLEHIAKSKTSEALSRLISLQATEATVVILDPDNTVKSEEQVDVELVQRGDIVRVTPGGKFPVDGRVIEGQSMVDESLITGEAMPVSKKPGSSVIAGSINQNGSLLIAATHVGSDTTLSQIVKLVEDAQTSKAPIQQFADKLSGYFVPFIVAVSVLTLFVWIIIGYHNFEIVEKYFPGYNKSISKGEVIVRFAFQAAITVLCIACPCSLGLATPTAVMVGTGVGAQNGILIKGGEPLEMAHKVKTVVFDKTGTITKGTPVVMQVKVLVESN-RMPSNKLLAIVGTAESNSEHPLGSAVIKYCKEVLNAETLGTCYDFQAVPGCGISCKVNNIEPLLHAANGPDNKRN----AVLVQIDGQ-------------HEDSILPSITVSQNPSNGSSPPQTYSVLIGNREWMNRNFLTLTAETDSLMTEHEKKGRTAVLVAVDGVLCGLIAIADTVKPEAALAIHSLRSMGLDIVLMTGDNSKTAKTIAAQVGITKVFAEVLPSHKVAKVKQLQ--------EQGTRVAMVGDGINDSPALAMADVGITIGSGTDVAIEAADVVLIRNDLLDVVASIDLSRKTVKRIRINFVFALIYNLVGIPIAAGVFMPVGLILQPWMGSAAMAASSVSVVFSSLLLKLYRKPSREKL 1419          

Query:  106 ARMKVDGMTCMSCVRNIEENLMKFTGVCGIMVSLLHAEATVIFDADIATVEDISNKIDEMGFDVTVKSSEVSNVKDKVVRSRIKFES---DINKSVEK-----SIETSLSSKLLLVRFCQENNYADIWHYSSIRSTEILSVIQQSEIYGVLVLEQCPTIRVIV--RVNGMTCQSCVDNIESTVGKKQGIISIKVFLEKSEAHALVDASLAGP-DVEEMINDMGFNSEMI-----------LEIFNDSCAGKPNNVSQKYEELKSNTIYPILSTTIVIKALKSIFCIFKIENHMRALPGVDKCSVNLIEEIGMIDYDSGKWNVQKIREEIESLGYLTELPKQNWNSTRQSSAVSLNEESRSKC------------------YLRITGMTCSSCVNKVESHLLKVEGVKSVLVALLAMKCEIIYDSAYVMPFQLSNRVKELGFNAEVIENGNEGIGIVN------------------------------------VLIRGMTCSSCVNHIENHISKIKGIASINVSLSTSKGKVEYFISECGPRDVIDAINDMGFDASLCDHLE 1563
            A + V+GMTC SCV+ IE+ +    GV  I VSL    A +I+DA + T + +   +++MGF+ T+  +    V       R+  E     I   + +      ++TSL  K+  V F        +     I    + S+  +    G +         V+V  ++ GMTC SC   IE  VGK +G+  IKV L+  EA  L    L  P D+   I + GF +++            +E   ++      ++ QK  + +++ I  I      I+ +    C+  IE+++ +  GV    V+L  ++ +I + S       + + IE+L   T       N    +   S+ + S + C                   + I GMTC SCV  +E  + K  GVKS+ V+L+     + YD A   P  +   ++++GF+A ++ N  +     +                                    + I GMTC+SCV +IE ++ + +GI S+ V+L   K +V Y      P  + + I ++GF+AS+ ++ +
Sbjct:   10 AFIPVEGMTCNSCVQTIEQKIGSINGVHSIKVSLEGKNAAIIYDAKLQTPKALQEAVEDMGFESTLSYANPQPVPMDSTFLRLSAEQSAEQIRSGLSQFKGVLDVKTSLEGKVACVTFIPSVVNPGLL-IQKIPGLSLDSMASKKTTSGSVESRSSVASDVLVKMKIEGMTCHSCTSTIEGKVGKLKGVQRIKVSLDSQEAQILYQPHLIKPEDIRTQIEEAGFIAQIKSKPPQKLGAIDIERLTNTQTNSNGDLPQKIPKHQNDLIRAIFQ----IEGMHCKSCVVNIESNIGSQHGVSSIEVSLENKLAVIHFYSNITTSDALIQAIEALSPGT-FKVSLCNHPELAETFSMQKNSEASCAKEIFSSPSNQDFCSKVTVINIEGMTCMSCVQSIEGLISKKPGVKSIQVSLVNNNGTVQYDPAVTSPEDIRAAIEDMGFDASLLANTGQADAFTSEASQKPFLNSLLPKERTNKETPVHSKPEKRTVNKCFIQITGMTCASCVANIERNLRREEGIYSVLVALMAGKAEVRYNPEVLQPSGIAELIQELGFEASVLENYD 565          

Query:  109 RMKVDGMTCMSCVRNIEENLMKFTGVCGIMVSLLHAEATVIFDADIATVEDISNKIDEMGFDVTVKSSEVSNVKDKVVRSRIKFESDINKSVEKSIETSLSSKLLLVRFCQENNYADIWHYSSIRSTEILSVIQQSEIYGVLVLEQCPTIRVIVRVNGMTCQSCVDNIESTVGKKQGIISIKVFLEKSEA----HALVDASLAGPDVEEMINDMGF-----NSEMILEIFNDSCAGKPNNVSQKYEELKSNTIYPILSTTIVIKALKSIFCIFKIENHMRALPGVDKCSVNLIEEIGMIDYDSGKWNVQKIREEIESLGYLTEL------------PKQNWNSTRQSSAVSLNEESRS--KCYLRITGMTCSSCVNKVESHLLKVEGVKSVLVALLAMKCEIIYDSAYVMPFQLSNRVKELGFNAEVIENGNEGIGIVNVLIRGMTCSSCVNHIENHISKIKGIASINVSLSTSKGKVEYFISECGPRDVIDAINDMGFDASLCDHLESNHAAADHINQM--IKQWRSSFFFSLICGIPXXXXXXXXXXXXXXXXHTII--HENGSNRTIMKSTVPMVCS-----GLSADNLILFVLATPVQFYGARYFYIQAYLSLKHKTTNMDVLVVMATXXXXXXXXXXXXXXMAFRRNTSPKTFFETSPMLIVFLSLGRWLEHIAKGKTSEALTKLMSLQAVEAT--LYTPEN---KERKIPINLVQRNDLIKILPGEKIPVDGKVVTGTSTCDESLITGESMPIEKTHGSDVIGGSINKSGMLIVKATHVGSDSALAQIVKLVEEAQTSKAPIQQLADRIAGMFVPSVLICAIITLIIWVIVGFSKPEI----LPKYVNELSVTEITWEHAFQLAITVLSIACPCSLGLXXXXXXXXXXXXXXXNGILIKGGEPLENIHKLNVIVFDKTGTITNGSPSVTRFLVLIGNGVREHIDKLLKILAAAESASEHPIGKAIITFSKARISNENLPEVLESSAVSGCGLGCKL-NLDPKTEVTKFVKNLINIESPSEETNILGQXXXXXXXXXXXXTYKDVIFPVRQHMAWTSDLCQTVTVIIGNRNWMLRNGILVDDEVDELMSEDENLGRTVILMAIDNELIAMISVADQVKREAALAVYTLKKMNIEVYLMTGDNSKTATAIARQVGIHYVFAEVLPSHKVAKVQQLQNTNRSLTSKRKMKVAMVGDGINDSPALAQSDVGIAIGTGTDVAVEAADVVLIRNSLLDVIAAIQLSKATVKRIRQNFIAATLYNLLGIPIAAGVLMPIGIEMMPWMXXXXXXXXXXXXXXXXXXXXXWKKPSEEKL 3930
            +MK++GMTC SC   IE  + K  GV  I VSL   EA +++   +   EDI  +I+E GF        ++ +K K  +     +      +E+   T            Q N+  D+         ++                    IR I ++ GM C+SCV NIES +G + G+ SI+V LE   A    ++ +  S A     E ++   F     N   + E F+     + +   + +    SN  +    T I I+ +  + C+  IE  +   PGV    V+L+   G + YD    + + IR  IE +G+   L            PK+  N   + + V    E R+  KC+++ITGMTC+SCV  +E +L + EG+ SVLVAL+A K E+ Y+   + P  ++  ++ELGF A V+EN ++G GI+ +L+RGMTC+SCV+ IE+ + K KG+   +V+L+T+K  +++     GPRD++  IND+GF  SL     S    A H++    I++W+ SF  SLI  IP M +M+  MF      H ++  H N +   I      MV       GLS  NL+  +L  PVQF G  YFYIQAY +LKH+T NMDVL+V+ATS+++IYS+IV+++++  +   +P TFF+T PML VF++LGRWLEHIAK KTSEAL++L+SLQA EAT  +  P+N    E ++ + LVQR D++++ PG K PVDG+V+ G S  DESLITGE+MP+ K  GS VI GSIN++G L++ ATHVGSD+ L+QIVKLVE+AQTSKAPIQQ AD+++G FVP ++  +++TL +W+I+G+   EI     P Y   +S  E+    AFQ AITVL IACPCSLGLATPTAVMVGTGVGA NGILIKGGEPLE  HK+  +VFDKTGTIT G+P V +  VL+ +  R   +KLL I+  AES SEHP+G A+I + K  ++ E L    +  AV GCG+ CK+ N++P         N  N    +    I GQ                + F +  H+   S   QT +V+IGNR WM RN + +  E D LM+E E  GRT +L+A+D  L  +I++AD VK EAALA+++L+ M +++ LMTGDNSKTA  IA QVGI  VFAEVLPSHKVAKV+QLQ        ++  +VAMVGDGINDSPALA +DVGI IG+GTDVA+EAADVVLIRN LLDV+A+I LS+ TVKRIR NF+ A +YNL+GIPIAAGV MP+G+ + PWM SAAMAASSVSVV  SLLLKL++KPS EKL
Sbjct:  172 KMKIEGMTCHSCTSTIEGKVGKLKGVQRIKVSLDSQEAQILYQPHLIKPEDIRTQIEEAGF--------IAQIKSKPPQKLGAID------IERLTNT------------QTNSNGDLPQKIPKHQNDL--------------------IRAIFQIEGMHCKSCVVNIESNIGSQHGVSSIEVSLENKLAVIHFYSNITTSDALIQAIEALSPGTFKVSLCNHPELAETFSMQKNSEASCAKEIFSS-PSNQDFCSKVTVINIEGMTCMSCVQSIEGLISKKPGVKSIQVSLVNNNGTVQYDPAVTSPEDIRAAIEDMGFDASLLASQKPFLNSLLPKERTN---KETPVHSKPEKRTVNKCFIQITGMTCASCVANIERNLRREEGIYSVLVALMAGKAEVRYNPEVLQPSGIAELIQELGFEASVLENYDDGTGILELLVRGMTCASCVHKIESRLMKTKGVLYSSVALATNKAHIKFDPEVIGPRDIMKIINDLGFSTSLVKKDRS----ASHLDHRVEIQRWKRSFLISLIFCIPVMGLMVHMMFMEN---HYLMPHHHNMTMEDIASYHPTMVLEYQIIPGLSIMNLVSLLLCIPVQFLGGWYFYIQAYKALKHRTANMDVLIVLATSVAFIYSLIVLIVAIFEKSKVNPITFFDTPPMLFVFIALGRWLEHIAKSKTSEALSRLISLQATEATVVILDPDNTVKSEEQVDVELVQRGDIVRVTPGGKFPVDGRVIEGQSMVDESLITGEAMPVSKKPGSSVIAGSINQNGSLLIAATHVGSDTTLSQIVKLVEDAQTSKAPIQQFADKLSGYFVPFIVAVSVLTLFVWIIIGYHNFEIVEKYFPGYNKSISKGEVIVRFAFQAAITVLCIACPCSLGLATPTAVMVGTGVGAQNGILIKGGEPLEMAHKVKTVVFDKTGTITKGTPVVMQVKVLVESN-RMPSNKLLAIVGTAESNSEHPLGSAVIKYCKEVLNAETLGTCYDFQAVPGCGISCKVNNIEPLLHAANGPDNKRN----AVLVQIDGQLF--------------ISFDI--HLG--SSPPQTYSVLIGNREWMNRNFLTLTAETDSLMTEHEKKGRTAVLVAVDGVLCGLIAIADTVKPEAALAIHSLRSMGLDIVLMTGDNSKTAKTIAAQVGITKVFAEVLPSHKVAKVKQLQ--------EQGTRVAMVGDGINDSPALAMADVGITIGSGTDVAIEAADVVLIRNDLLDVVASIDLSRKTVKRIRINFVFALIYNLVGIPIAAGVFMPVGLILQPWMGSAAMAASSVSVVFSSLLLKLYRKPSREKL 1399          

Query:  106 ARMKVDGMTCMSCVRNIEENLMKFTGVCGIMVSLLHAEATVIFDADIATVEDISNKIDEMGFDVTVKSSEVSNVKDKVVRSRIKFES---DINKSVEK-----SIETSLSSKLLLVRFCQENNYADIWHYSSIRSTEILSVIQQSEIYGVLVLEQCPTIRVIV--RVNGMTCQSCVDNIESTVGKKQGIISIKVFLEKSEAHALVDASLAGP-DVEEMINDMGFNSEMI-----------LEIFNDSCAGKPNNVSQKYEELKSNTIYPILSTTIVIKALKSIFCIFKIENHMRALPGVDKCSVNLIEEIGMIDYDSGKWNVQKIREEIESLGYLTELPKQNWNSTRQSSAVSLNEESRSKC------------------YLRITGMTCSSCVNKVESHLLKVEGVKSVLVALLAMKCEIIYDSAYVMPFQLSNRVKELGFNAEVI-------------ENGNEGIGI--------VN---VLIRGMTCSSCVNHIENHISKIKGIASINVSLSTSKGKVEYFISECGPRDVIDAINDMGFDASLCDHLE 1563
            A + V+GMTC SCV+ IE+ +    GV  I VSL    A +I+DA + T + +   +++MGF+ T+  +    V       R+  E     I   + +      ++TSL  K+  V F        +     I    + S+  +    G +         V+V  ++ GMTC SC   IE  VGK +G+  IKV L+  EA  L    L  P D+   I + GF +++            +E   ++      ++ QK  + +++ I  I      I+ +    C+  IE+++ +  GV    V+L  ++ +I + S       + + IE+L   T       N    +   S+ + S + C                   + I GMTC SCV  +E  + K  GVKS+ V+L+     + YD A   P  +   ++++GF+A ++             E  N+   +        VN   + I GMTC+SCV +IE ++ + +GI S+ V+L   K +V Y      P  + + I ++GF+AS+ ++ +
Sbjct:   10 AFIPVEGMTCNSCVQTIEQKIGSINGVHSIKVSLEGKNAAIIYDAKLQTPKALQEAVEDMGFESTLSYANPQPVPMDSTFLRLSAEQSAEQIRSGLSQFKGVLDVKTSLEGKVACVTFIPSVVNPGLL-IQKIPGLSLDSMASKKTTSGSVESRSSVASDVLVKMKIEGMTCHSCTSTIEGKVGKLKGVQRIKVSLDSQEAQILYQPHLIKPEDIRTQIEEAGFIAQIKSKPPQKLGAIDIERLTNTQTNSNGDLPQKIPKHQNDLIRAIFQ----IEGMHCKSCVVNIESNIGSQHGVSSIEVSLENKLAVIHFYSNITTSDALIQAIEALSPGT-FKVSLCNHPELAETFSMQKNSEASCAKEIFSSPSNQDFCSKVTVINIEGMTCMSCVQSIEGLISKKPGVKSIQVSLVNNNGTVQYDPAVTSPEDIRAAIEDMGFDASLLASQKPFLNSLLPKERTNKETPVHSKPEKRTVNKCFIQITGMTCASCVANIERNLRREEGIYSVLVALMAGKAEVRYNPEVLQPSGIAELIQELGFEASVLENYD 553          

Query:   97 LGSARMKVDGMTCMSCVRNIEENLMKFTGVCGIMVSLLHAEATVIFDADIATVEDISNKIDEMGFDVTV--KSSEVSNVK-----DKVVRSRIK----------FESDINK--SVEKSIETSLSSKLLLVRFCQENNYA--------DIWHYSSIRSTE---ILSVIQQSEIYGVLVLEQCPTIR---VIVRVNGMTCQSCVDNIESTVGKKQGIISIKVFLE-KSEAHALVDASLAGPDVEEMINDM---GFNSEMILEI-FNDSCAGKPNNVSQKYEELKSNTIYPILSTTIVIKALKSIFCIFKIENHMRALPGVDKCSVNLIEEIGMIDYDSGKWNVQKIREEIESLGYLTELPKQNWNS------------TRQSSA-----VSLNEESRSKCYLRITGMTCSSCVNKVESHLLKVEGVKSVLVALLAMKCEIIYDSAYVMPFQLSNRVKELGFNAEVIENGNEGIGIVNVLIRGMTCSSCVNHIENHISKIKGIASINVSLSTSKGKVEYFISECGPRDVIDAINDMGFDASLCDHLESNHAAADHINQMIKQWRSSFFFSLICGIPXXXXXXXXXXXXXXXXHTIIHENGSNRTIMKSTVPMVCSGLSADNLILFVLATPVQFYGARYFYIQAYLSLKHKTTNMDVLVVMATXXXXXXXXXXXXXXMAFRRNTSPKTFFETSPMLIVFLSLGRWLEHIAKGKTSEALTKLMSLQAVEATLYTPEN-----KERKIPINLVQRNDLIKILPGEKIPVDGKVVTGTSTCDESLITGESMPIEKTHGSDVIGGSINKSGMLIVKATHVGSDSALAQIVKLVEEAQTSKAPIQQLADRIAGMFVPSVLICAIITLIIWVIVGFSKPEIL----PKYVNELSVTEITWEHAFQLAITVLSIACPCSLGLXXXXXXXXXXXXXXXNGILIKGGEPLENIHKLNVIVFDKTGTITNGSPSVTRFLVLIGNGVREHIDKLLKILAAAESASEHPIGKAIITFSKARISNENLPEVLESSAVSGCGLGCKLNLDPKTEVTKFVKNLINIESPSEETNILGQXXXXXXXXXXXXTYKDVIFPVRQHMAWTSDLCQTV-------TVIIGNRNWMLRNGILVDDEVDELMSEDENLGRTVILMAIDNELIAMISVADQVKREAALAVYTLKKMNIEVYLMTGDNSKTATAIARQVGIHYVFAEVLPSHKVAKVQQLQNTNRSLTSKRKMKVAMVGDGINDSPALAQSDVGIAIGTGTDVAVEAADVVLIRNSLLDVIAAIQLSKATVKRIRQNFIAATLYNLLGIPIAAGVLMPIGIEMMPWMXXXXXXXXXXXXXXXXXXXXXWKKPSEEKLITPEYINFIQSSGLSESQIIVRRGID 4008
            +GS  + + GMTC SCV++IE  + K +GV GI V L    A V +     T   I  +I++MGFD ++  +S   S+VK     D V++ R++           E  I K   V+K I+ SL+ +  ++ +      A        D+   +SI++      L  I    +   +            V + ++GM C+SCV NIE  V    GI SI+V L+ K+    L   S +   ++E I ++    F   + + +    S A    + S + + +  N         I I  +    C+  IEN +    GV    V+L E  G I Y+  + N +++R  IE +G+ + L    +NS            TRQ S      +   + +  KC+L+ITGMTC SCV+ +E +L K +G+ SVLVAL++ K E+ +    + P +++  V++LGF A V+E+     G V ++I GMTC+SCV++IE+ + +  GI   +V+L+T K +V++     GPRD+I  I  +GF ASL     + H   DH  + IKQWR+SF FSL+ GIP + +M++ +   K   +T++ +        ++ VP    GLS  NL+ F+L T VQ  G RYFY+QAY SLKHK TNMDVL+V+AT+I+YIYSV+++ ++M  + + SP+TFF+T PML +F++LGRWLEHIAK KTSEAL KL+SLQA EA + T        +E ++ + LVQR D++K++PG K PVDGKV+ GTS  DESLITGE MP+ K  GS VI GSIN  G ++V+ATHVGS++ LAQIVKLVEEAQ SKAPIQQLAD+I+G FVP ++I +++TL+ W+I+GF   +I+    P Y   +S TE+    AFQ +ITVLSIACPC+LGLATPTAVMVGTGV A NGILIKGGEPLE  HK+  ++FDKTGTIT+G P V R L L+G+ V+  + ++L ++  AE++SEHP+G A+  + K  +  E L    +  AV GCG+ CK+N               NIES                           + P+   +A  + LC T        TV+IGNR WM RNG+ +  +VDE MS  E  G+T +L+AID EL  MI++AD VK+EAALAV+TLK M I+V L+TGDN KTA AIA QVGI  VFAEVLPSHKVAKVQ LQ+ N+        +VAMVGDG+NDSPALA++DVGIAIGTGTDVA+EAAD+VLIRN LLDV+A+I LSK TV+RIR NF+ A +YNLLGIPIAAGV MP G+ + PWM SAAMAASSVSVV  SL LK ++KP  ++    E         L+ SQI V  G+D
Sbjct:   43 VGSVVVAIQGMTCQSCVQSIEGRISKVSGVVGINVCLEQNNAIVNYLQTEITPHKICEEIEDMGFDASLSEQSGMPSSVKSSYYGDNVIKIRVEGMTCQSCVNTIEGKIGKIQGVQK-IKVSLTGQEAVITYQSHIIQAEDLRKYIEDMGFEASIKNKPDPTKLGTIDIERLQNSIAENHSGHTNSNTVTLGIDGMHCKSCVHNIEGYVSGLAGIQSIRVSLKNKNAVVCLSQGSTSLLSLKESIENLPPGKFKVTLPVGVEKGQSLARNSTHSSHRDQSMGGNI------AIISIGGMTCQSCVSSIENMISQRKGVLHILVSLDEGNGNIFYNPCETNAEELRAAIEDMGFHSTLVCSEYNSKEEENKQTPPKATRQISGSRDYILDKYDTAPEKCFLQITGMTCISCVSNIERNLKKKDGIVSVLVALMSGKAEVKFYPDRIEPLEIAQLVEDLGFGASVMEDYTASDGNVELIITGMTCASCVHNIESRLMRTPGILQASVALATCKAQVKFDPEIVGPRDIIRIIEGIGFQASLAKRDPTAHKL-DH-KEEIKQWRNSFLFSLLFGIPVIILMIYMLAANKDHHNTMVLD--------RNIVP----GLSIINLVFFILCTFVQTLGGRYFYVQAYKSLKHKATNMDVLIVLATTIAYIYSVVILTVAMVEKADKSPETFFDTPPMLFMFIALGRWLEHIAKSKTSEALAKLISLQATEAAVVTFGANQIILREEQVAVELVQRGDIVKVVPGGKFPVDGKVIEGTSMADESLITGEPMPVRKKPGSMVIAGSINAHGTVLVEATHVGSETTLAQIVKLVEEAQMSKAPIQQLADKISGYFVPFIIIISVVTLVTWIIIGFVNFDIIIKYFPSYSKNISKTEVIIRVAFQTSITVLSIACPCALGLATPTAVMVGTGVAAQNGILIKGGEPLEMAHKIKAVMFDKTGTITHGVPKVMRVL-LLGDVVKMPLKRMLAVVGTAEASSEHPLGMAVTKYCKEELGTELLGYCTDFQAVPGCGISCKVN---------------NIES---------------------------VLPI--WLARLTYLCPTGAQAPLAHTVLIGNREWMRRNGLHISTDVDEAMSSHEMKGQTAVLVAIDGELCGMIAIADTVKQEAALAVHTLKSMGIDVVLITGDNRKTAKAIATQVGIKKVFAEVLPSHKVAKVQALQSDNK--------RVAMVGDGVNDSPALARADVGIAIGTGTDVAIEAADIVLIRNDLLDVVASIHLSKRTVRRIRLNFVFALIYNLLGIPIAAGVFMPAGLVLQPWMGSAAMAASSVSVVLSSLQLKCYRKPDSDRY---EARAQGHMKPLTPSQISVHIGMD 1340          

Query: 1336 EGIGIVNVLIRGMTCSSCVNHIENHISKIKGIASINVSLSTSKGKVEYFISECGPRDVIDAINDMGFDASLCDH 1557
            + +G V V I+GMTC SCV  IE  ISK+ G+  INV L  +   V Y  +E  P  + + I DMGFDASL + 
Sbjct:   41 DDVGSVVVAIQGMTCQSCVQSIEGRISKVSGVVGINVCLEQNNAIVNYLQTEITPHKICEEIEDMGFDASLSEQ 114          

Query:  109 RMKVDGMTCMSCVRNIEENLMKFTGVCGIMVSLLHAEATVIFDADIATVEDISNKIDEMGFDVTVKSSEVSNVKDKVVRSRIKFESDINKSVEKSIETSLSSKLLLVRFCQENNYADIWHYSSIRSTEILSVIQQSEIYGVLVLEQCPTIRVIVRVNGMTCQSCVDNIESTVGKKQGIISIKVFLEKSEAHALVDASLAGPDVEEMINDMGFNSEMILEIFNDSCAGKPNN-VSQKYEELKSNTIYPILSTTIVIKALKSIFCIFKIENHMRALPGVDKCSVNLIEEIGMIDYDSGKWNVQKIREEIESLGY--------LTELPKQNW---NSTRQS------SAVSLNEESRS-----------------------KCYLRITGMTCSSCVNKVESHLLKVEGVKSVLVALLAMKCEIIYDSAYVMPFQLSNRVKELGFNAEVIENGNEGIGIVNVLIRGMTCSSCVNHIENHISKIKGIASINVSLSTSKGKVEYFISECGPRDVIDAINDMGFDASLCDHLESNHAAADHINQMIKQWRSSFFFSLICGIPXXXXXXXXXXXXXXXXHTIIHENGSNRTIMKSTVPMVCSGLSADNLILFVLATPVQFYGARYFYIQAYLSLKHKTTNMDVLVVMATXXXXXXXXXXXXXXMAFRRNTSPKTFFETSPMLIVFLSLGRWLEHIAKGKTSEALTKLMSLQAVEATLYT--PEN---KERKIPINLVQRNDLIKILPGEKIPVDGKVVTGTSTCDESLITGESMPIEKTHGSDVIGGSINKSGMLIVKATHVGSDSALAQIVKLVEEAQTSKAPIQQLADRIAGMFVPSVLICAIITLIIWVIVGFSKPEILPKYV----NELSVTEITWEHAFQLAITVLSIACPCSLGLXXXXXXXXXXXXXXXNGILIKGGEPLENIHKLNVIVFDKTGTITNGSPSVTRFLVLIGNGVREHIDKLLKILAAAESASEHPIGKAIITFSKARISNENLPEVLESSAVSGCGLGCKL-NLDPKTEVTKFVKNLINIESPSEETNILGQXXXXXXXXXXXXTYKDVIFPVRQHMAWTSDLCQTVTVIIGNRNWMLRNGILVDDEVDELMSEDENLGRTVILMAIDNELIAMISVADQVKREAALAVYTLKKMNIEVYLMTGDNSKTATAIARQVGIHYVFAEVLPSHKVAKVQQLQNTNRSLTSKRKMKVAMVGDGINDSPALAQSDVGIAIGTGTDVAVEAADVVLIRNSLLDVIAAIQLSKATVKRIRQNFIAATLYNLLGIPIAAGVLMPIGIEMMPWMXXXXXXXXXXXXXXXXXXXXXWKKPSEEKLITPEYINFIQSSGLSESQIIVRRGID 4008
            +++V+GMTC SCV +IE  + K  GV  I VSL + EA + +   +   ED+ + I +MGF+        + +K++    R+    D+NK    +++    S + +      N++  + H  S  +T                        + +R++GM C+SCV NIE  +G+  G+ +I V LE   A    D S   P   +   +        + + +     +P +  SQ+++E       P  +  + I  +     +  IE+ +    GV + S++L E  G + YD    ++ ++R  +E +G+         T  P +N+   NS  Q+      S   +  ++R                        KC+++I GMTC+SCV+ +E  L +  G+ SVLVAL++ K E+ YD   +   +++  +++LGF A V+E+     G + ++I GMTC+SCV++IE+ +++  GI   +V+L+TSK  V++     GPRD+I  I ++GF ASL     + H   DH  + IKQW+ SF  SL+ GIP M +M++ +      + T++ ++             +  GLS  NLI F+L T VQF G  YFY+QAY SL+H++ NMDVL+V+AT+I+Y YS++++V+++A +   SP TFF+T PML VF++LGRWLEH+AK KTSEAL KLMSLQA EAT+ T   +N   +E ++P+ LVQR D+IK++PG K PVDGKV+ G +  DESLITGE+MP+ K  GS VI GSIN  G +++KATHVG+D+ LAQIVKLVEEAQ SKAPIQQLADR +G FVP ++I + +TL++W+++GF    ++ KY       +S TE+    AFQ +ITVL IACPCSLGLATPTAVMVGTGV A NG+LIKGG+PLE  HK+  ++FDKTGTIT+G P V RFL L+ +     + K+L ++  AE++SEHP+G A+  + K  +  E L    +  AV GCG+ CK+ N++     +    + + + +P                            P  +         QT +V+IGNR WM RNG+ +  ++ + M++ E  G+T IL+AID  L  MI++AD VK EAALA+YTLK M ++V L+TGDN KTA AIA QVGI+ VFAEVLPSHKVAKVQ+LQN  +        KVAMVGDG+NDSPALAQ+DVGIAIGTGTDVA+EAADVVLIRN LLDV+A+I LSK TV+RIR N + A +YN++GIPIAAGV MPIGI + PWM SAAMAASSVSVV  SL LK ++KP  E+    E     +   LS SQ+ V  G+D
Sbjct:  156 KLRVEGMTCQSCVSSIEGKIRKLQGVVRIKVSLSNQEAVITYQPYLIQPEDLRDHICDMGFE--------AAIKNRTAPLRLG-PIDVNKLESTNLKKETVSPVQI-----SNHFETLGHQGSYLAT------------------------LPLRIDGMHCKSCVLNIEGNIGQLPGVQNIHVSLENKTAQIQYDPSCVTPMFLQTAIEALPPGHFKVSLPDGVEENEPQSGSSQRHQEQG-----PGRTAVLTISGITCASSVQPIEDMLSQRKGVQQTSISLAEGTGAVLYDPSIVSLDELRTAVEDMGFEVSVNSETFTINPVRNFKSGNSVPQTMGDIAGSVQKMAPDTRGLPTHQGPGHSSETPSSPGATASQKCFVQIKGMTCASCVSNIERSLQRHAGILSVLVALMSGKAEVKYDPEIIQSPRIAQLIQDLGFEASVMEDNTVSEGDIELIITGMTCASCVHNIESKLTRTNGITYASVALATSKAHVKFDPEIVGPRDIIKIIEEIGFHASLAQRNPNAHHL-DHKTE-IKQWKKSFLCSLVFGIPVMGLMVYMLIPSSTPQETMVLDHN------------IIPGLSVLNLIFFILCTFVQFLGGWYFYVQAYKSLRHRSANMDVLIVLATTIAYAYSLVILVVAVAEKAEKSPVTFFDTPPMLFVFIALGRWLEHVAKSKTSEALAKLMSLQATEATVVTLGEDNLILREEQVPMELVQRGDVIKVVPGGKFPVDGKVLEGNTMADESLITGEAMPVTKKPGSIVIAGSINAHGSVLLKATHVGNDTTLAQIVKLVEEAQMSKAPIQQLADRFSGYFVPFIIIISTLTLVVWIVIGFVDFGVVQKYFPSPSKHISQTEVIIRFAFQTSITVLCIACPCSLGLATPTAVMVGTGVAAQNGVLIKGGKPLEMAHKIKTVMFDKTGTITHGVPRVMRFL-LLADVATLPLRKVLAVVGTAEASSEHPLGVAVTKYCKEELGTETLGYSTDFQAVPGCGISCKVSNVEGILARSDLTAHPVGVGNP----------------------------PTGEGAG-----PQTFSVLIGNREWMRRNGLTISSDISDAMTDHEMKGQTAILVAIDGVLCGMIAIADAVKPEAALAIYTLKSMGVDVALITGDNRKTARAIATQVGINKVFAEVLPSHKVAKVQELQNEGK--------KVAMVGDGVNDSPALAQADVGIAIGTGTDVAIEAADVVLIRNDLLDVVASIHLSKRTVRRIRVNLVLALIYNMVGIPIAAGVFMPIGIVLQPWMGSAAMAASSVSVVLSSLQLKCYRKPDLERY---EAQAHGRMKPLSASQVSVHIGMD 1404          

Query:  562 VIVRVNGMTCQSCVDNIESTVGKKQGIISIKVFLEKSEAHALVDASLAGP-DVEEMINDMGFNSEM---------------ILEIFN-DSCAGKPNNVSQKYEELKSNTIYPILSTTIVIKALKSIFCIFKIENHMRALPGVDKCSVNLIEEIGMIDYDSGKWNVQKIREEIESLG---YLTELPKQNWNSTRQSSAVSLNEESRS--KCYLRITGMTCSSCVNKVESHLLKVEGVKSVLVALLAMKCEIIYDSAYVMPFQLSNRVKELGFNAEV------------IENGN--------------------------EGIGIVN---------------VLIRGMTCSSCVNHIENHISKIKGIASINVSLSTSKGKVEYFISECGPRDVIDAINDMGFDASLCD 1554
            V +RV GMTCQSCV +IE  + K QG++ IKV L   EA       L  P D+ + I DMGF + +                LE  N       P  +S  +E L     Y + +  + I  +    C+  IE ++  LPGV    V+L  +   I YD        ++  IE+L    +   LP     +  QS +   ++E        L I+G+TC+S V  +E  L + +GV+   ++L      ++YD + V   +L   V+++GF   V             ++GN                          +G G  +               V I+GMTC+SCV++IE  + +  GI S+ V+L + K +V+Y         +   I D+GF+AS+ +
Sbjct:  155 VKLRVEGMTCQSCVSSIEGKIRKLQGVVRIKVSLSNQEAVITYQPYLIQPEDLRDHICDMGFEAAIKNRTAPLRLGPIDVNKLESTNLKKETVSPVQISNHFETLGHQGSY-LATLPLRIDGMHCKSCVLNIEGNIGQLPGVQNIHVSLENKTAQIQYDPSCVTPMFLQTAIEALPPGHFKVSLPDGVEENEPQSGSSQRHQEQGPGRTAVLTISGITCASSVQPIEDMLSQRKGVQQTSISLAEGTGAVLYDPSIVSLDELRTAVEDMGFEVSVNSETFTINPVRNFKSGNSVPQTMGDIAGSVQKMAPDTRGLPTHQGPGHSSETPSSPGATASQKCFVQIKGMTCASCVSNIERSLQRHAGILSVLVALMSGKAEVKYDPEIIQSPRIAQLIQDLGFEASVME 559          

Query:  550 PTIRVIVRVNGMTCQSCVDNIESTVGKKQGIISIKVFLEKSEAHA-LVDASLAGPDVEEMINDMGFNSEMILEIFNDSCAGKPNNVSQKYEELKSNTIYPILSTTIVIKALKSIFCIFKIENHMRALPGVDKCSVNLIEEIGMIDYDSGKWNVQKIREEIESLGYLTELPKQNWNSTRQSSAVSLN--------EESRSKCY-------------------LRITGMTCSSCVNKVESHLLKVEGVKSVLVALLAMKCEIIYDSAYVMPFQLSNRVKEL-----------GFNAEVIENGN------EGIGIVNVL-IRGMTCSSCVNHIENHISKIKGIASINVSLSTSKGKVEYFISECGPRDVIDAINDMGFDASL 1548
            P    +V + GMTC SCV +IE  +   +GI++IKV LE+  A    V + +    +   I DMGF +           A  P+  S   E +            + ++ +    C+  IE  +R L GV +  V+L  +  +I Y       + +R+ I  +G+  E   +N  +  +   + +N        +E+ S                      LRI GM C SCV  +E ++ ++ GV+++ V+L     +I YD + V P  L   ++ L           G      ++G+      +G G   VL I G+TC+S V  IE+ +S+ KG+   ++SL+   G V Y  S     ++  A+ DMGF+ S+
Sbjct:   66 PAATDVVNILGMTCHSCVKSIEDRISSLKGIVNIKVSLEQGSATVRYVPSVMNLQQICLQIEDMGFEASAA----EGKAASWPSRSSPAQEAV----------VKLRVEGMTCQSCVSSIEGKIRKLQGVVRIKVSLSNQEAVITYQPYLIQPEDLRDHICDMGF--EAAIKNRTAPLRLGPIDVNKLESTNLKKETVSPVQISNHFETLGHQGSYLATLPLRIDGMHCKSCVLNIEGNIGQLPGVQNIHVSLENKTAQIQYDPSCVTPMFLQTAIEALPPGHFKVSLPDGVEENEPQSGSSQRHQEQGPGRTAVLTISGITCASSVQPIEDMLSQRKGVQQTSISLAEGTGAVLYDPSIVSLDELRTAVEDMGFEVSV 428          

Query: 1051 LPKQNW-NSTRQSSAV-------SLNEESRSKC---YLRITGMTCSSCVNKVESHLLKVEGVKSVLVALLAMKCEIIYDSAYVMPFQLSNRVKELGFNAEVIENGNEGI---------GIVNVLIRGMTCSSCVNHIENHISKIKGIASINVSLSTSKGKVEYFISECGPRDVIDAINDMGFDASL 1548
            LP + W  S +QS A         L+  S S      + I GMTC SCV  +E  +  ++G+ ++ V+L      + Y  + +   Q+  +++++GF A   E                +V + + GMTC SCV+ IE  I K++G+  I VSLS  +  + Y      P D+ D I DMGF+A++
Sbjct:   35 LPGRPWEQSMKQSFAFDNVGYEGGLDSTSSSPAATDVVNILGMTCHSCVKSIEDRISSLKGIVNIKVSLEQGSATVRYVPSVMNLQQICLQIEDMGFEASAAEGKAASWPSRSSPAQEAVVKLRVEGMTCQSCVSSIEGKIRKLQGVVRIKVSLSNQEAVITYQPYLIQPEDLRDHICDMGFEAAI 220          

Query: 1348 IVNVLIRGMTCSSCVNHIENHISKIKGIASINVSLSTSKGKVEYFISECGPRDVIDAINDMGFDASLCD 1554
            +VN+L  GMTC SCV  IE+ IS +KGI +I VSL      V Y  S    + +   I DMGF+AS  +
Sbjct:   71 VVNIL--GMTCHSCVKSIEDRISSLKGIVNIKVSLEQGSATVRYVPSVMNLQQICLQIEDMGFEASAAE 137          

Query:  574 VNGMTCQSCVDNIESTVGKKQGIISIKVFLEKSEAHALVDASLAGPDVEEMINDMGFNSEMILEIFNDSCAGKPNNVSQKYEELKSNTIYPILSTTIVIK--ALKSIFCIFKIENHMRALPGVDKCSVNLIEEIGMIDYDSGKWNVQKIREEIESLGYLTELP---KQNWNSTRQSSA-----VSLNE------ESRSKCYLRITGMTCSSCVNKVESHLLKVEGVKSVLVALLAMKCEIIYDSAYVMPFQLSNRVKELGFNAEVIENGNEGIGIVNVLIRGMTCSSCVNHIENHISKIKGIASINVSLSTSKGKVEYFISECGPRDVIDAINDMGFDASLCDHLES-NHAAADHINQMIKQWRSSFFFSLICGIPXXXXXXXXXXXXXXXXHTIIHENGSNRTIMKSTVPM-----VCSGLSADNLILFVLATPVQFYGARYFYIQAYLSLKHKTTNMDVLVVMATXXXXXXXXXXXXXXMAFRRNTSPKTFFETSPMLIVFLSLGRWLEHIAKGKTSEALTKLMSLQAVEATLYT--PEN---KERKIPINLVQRNDLIKILPGEKIPVDGKVVTGTSTCDESLITGESMPIEKTHGSDVIGGSINKSGMLIVKATHVGSDSALAQIVKLVEEAQTSKAPIQQLADRIAGMFVPSVLICAIITLIIWVIVGFSKPEI----LPKYVNELSVTEITWEHAFQLAITVLSIACPCSLGLXXXXXXXXXXXXXXXNGILIKGGEPLENIHKLNVIVFDKTGTITNGSPSVTRFLVLI-GNGVREHIDKLLKILAAAESASEHPIGKAIITFSKARISNENLPEVLESSAVSGCGLGCKLNLDPKTEVTKFVKNLINIESPSEETNILGQXXXXXXXXXXXXTYKDVIFPVRQHMAWTSDLCQTVTVIIGNRNWMLRNGILVDDEVDELMSEDENLGRTVILMAIDNELIAMISVADQVKREAALAVYTLKKMNIEVYLMTGDNSKTATAIARQVGIHYVFAEVLPSHKVAKVQQLQNTNRSLTSKRKMKVAMVGDGINDSPALAQSDVGIAIGTGTDVAVEAADVVLIRNSLLDVIAAIQLSKATVKRIRQNFIAATLYNLLGIPIAAGVLMPIGIEMMPWMXXXXXXXXXXXXXXXXXXXXXWKKPSEEKLITPEYINFIQSSGLSESQIIVRRGID 4008
            + GM C+SCV NIES +   Q + SI V LE   A    +ASL  P++     +     +  + I ++  +   +  S   +++  N +   L+   VI    +    C+  IE  +   PGV    V+L    G I++D    + + +RE IE +G+   LP   K+      Q S       S NE        ++KCY++++GMTC+SCV  +E +L + EG+ SVLVAL+A K E+ Y+ A + P  ++  ++ELGF A V+EN  EG GI+ +++RGMTC+SCV+ IE+ ++K KGI   +V+L+T+K  ++Y     GPRD+I  I  +GF+ASL     S NH   DH  + IKQWR SF  SL   IP M +M++ M     +     ++N SN  ++     M     +  GLS  NL+  +L  PVQF G  YFYIQAY +LKHKT NMDVL+V+AT+I++ YS+++++++M  R   +P TFF+T PML VF++LGRWLEHIAKGKTSEAL KL+SLQA EAT+ T   EN    E ++ + LVQR D+IK++PG K PVDG+V+ G S  DESLITGE+MP+ K  GS VI GSIN++G L+++ATHVG+D+ L+QIVKLVEEAQTSKAPIQQ AD+++G FVP +++ +I+TL++W+I+GF   EI     P Y   +S TE     AFQ +ITVL IACPCSLGLATPTAVMVGTGVGA NGILIKGGEPLE  HK+ V+VFDKTGTIT+G+P V +  VL+  N +    +K+L I+  AES SEHP+G A+  + K  +  E L    +   V GCG+ CK        VT     L       EE NI   ++      + + +    +  +  H++   +  Q   V+IGNR WM+RNG+++ ++VDE M E E  GRT +L+ ID+EL  +I++AD VK EA LAV+ LK M +EV LMTGDNSKTA +IA QVGI  VFAEVLPSHKVAKV+QLQ   +        +VAMVGDGINDSPALA ++VGIAIGTGTDVA+EAADVVLIRN LLDV+A+I LS+ TVKRIR NF+ A +YNL+GIPIAAGV +PIG+ + PWM SAAMAASSVSVV  SL LKL++KP+ +     E      +   S S+I V  GID
Sbjct:  283 IEGMHCKSCVSNIESALSTLQYVSSIVVSLENRSAIVKYNASLVTPEMLRKAIEAISPGQYRVSIASEVESTASSPSSSSLQKMPLNIVSQPLTQEAVININGMTCNSCVQSIEGVISKKPGVKSIHVSLANSTGTIEFDPLLTSPETLREAIEDMGFDAALPADMKEPLVVIAQPSLETPLLPSSNELENVMTSVQNKCYIQVSGMTCASCVANIERNLRREEGIYSVLVALMAGKAEVRYNPAVIQPRVIAEFIRELGFGAMVMENAGEGNGILELVVRGMTCASCVHKIESTLTKHKGIFYCSVALATNKAHIKYDPEIIGPRDIIHTIGSLGFEASLVKKDRSANHL--DH-KREIKQWRGSFLVSLFFCIPVMGLMVYMMVMDHHLATLHHNQNMSNEEMINMHSAMFLERQILPGLSIMNLLSLLLCLPVQFCGGWYFYIQAYKALKHKTANMDVLIVLATTIAFAYSLVILLVAMFERAKVNPITFFDTPPMLFVFIALGRWLEHIAKGKTSEALAKLISLQATEATIVTLNSENLLLSEEQVDVELVQRGDIIKVVPGGKFPVDGRVIEGHSMVDESLITGEAMPVAKKPGSTVIAGSINQNGSLLIRATHVGADTTLSQIVKLVEEAQTSKAPIQQFADKLSGYFVPFIVLVSIVTLLVWIIIGFQNFEIVETYFPGYNRSISRTETIIRFAFQASITVLCIACPCSLGLATPTAVMVGTGVGAQNGILIKGGEPLEMAHKVKVVVFDKTGTITHGTPVVNQVKVLVESNKISR--NKILAIVGTAESNSEHPLGAAVTKYCKKELDTETLGTCTDFQVVPGCGISCK--------VTNIEGLLHKSNLKIEENNIKNASLVQIDAINEQSSTSSSMI-IDAHLSNAVN-TQQYKVLIGNREWMIRNGLVISNDVDESMIEHERRGRTAVLVTIDDELCGLIAIADTVKPEAELAVHILKSMGLEVVLMTGDNSKTARSIASQVGITKVFAEVLPSHKVAKVKQLQEEGK--------RVAMVGDGINDSPALAMANVGIAIGTGTDVAIEAADVVLIRNDLLDVVASIDLSRKTVKRIRINFVFALIYNLVGIPIAAGVFLPIGLVLQPWMGSAAMAASSVSVVLSSLFLKLYRKPTYDNY---ELHPRSHTGQRSPSEISVHVGID 1433          

Query:  103 SARMKVDGMTCMSCVRNIEENLMKFTGVCGIMVSLLHAEATVIFDADIATVEDISNKIDEMGFDVTVKSSE----VSNVKDKVVRSRIKFESDINKSVEKSIETSLSSKLLL-VRFCQENNYADIWHYSSIRS-TEILSVIQ--------QSEIYGVLVLEQCPT---IRVIVRVNGMTCQSCVDNIESTVGKKQGIISIKVFLEKSEAHALVDASL-AGPDVEEMINDMGFNSEM--------ILEIFNDSCAGKPNNVSQKYEELKSNTIYPILSTTI-VIKALKSIFCIFKIENHMRALPGVDKCSVNLIEEIGMIDYDSGKWNVQKIREEIESLG---YLTELPKQNWNSTRQSSAVSL--------NEESRSKCYLRITGMTCSSCVNKVESHLLKVEGVKSVLVALLAMKCEIIYDSAYVMPFQLSNRVKELGFNAEVIENGNEGIGIV-----------------NVL----------IRGMTCSSCVNHIENHISKIKGIASINVSLSTSKGKVEYFISECGPRDVIDAINDMGFDA 1542
            S  + V+GMTC+SCVR IE+ + K  GV  I VSL    AT+I+D  + T + +   ID+MGFD  + ++     ++N     V + +    D  +S      T L +K +  V+   +   A +    S+ S ++I+ ++         Q +  G       P    + + ++V GMTC SC   IE  VGK QG+  IKV L+  EA  +    L    ++++ I  +GF + +        +  I  +     P   S+  ++ KS + YP  STT+  I+ +    C+  IE+ +  L  V    V+L     ++ Y++     + +R+ IE++    Y   +  +  ++    S+ SL        ++    +  + I GMTC+SCV  +E  + K  GVKS+ V+L      I +D     P  L   ++++GF+A +  +  E + ++                 NV+          + GMTC+SCV +IE ++ + +GI S+ V+L   K +V Y  +   PR + + I ++GF A
Sbjct:    9 SITITVEGMTCISCVRTIEQQIGKVNGVHHIKVSLEEKSATIIYDPKLQTPKTLQEAIDDMGFDALLHNANPLPVLTNTVFLTVTAPLTLPWDHIQS------TLLKTKGVTGVKISPQQRSAVVTIIPSVVSASQIVELVPDLSLDMGTQEKKSGACEEHSTPQAGEVMLKMKVEGMTCHSCTSTIEGKVGKLQGVQRIKVSLDNQEATIVFQPHLITAEEIKKQIEAVGFPAFIKKQPKYLKLGAIDVERLKNTPVKSSEGSQQ-KSPS-YPSDSTTMFTIEGMHCKSCVSNIESALSTLQYVSSIVVSLENRSAIVKYNASLVTPEMLRKAIEAISPGQYRVSIASEVESTASSPSSSSLQKMPLNIVSQPLTQEAVININGMTCNSCVQSIEGVISKKPGVKSIHVSLANSTGTIEFDPLLTSPETLREAIEDMGFDAALPADMKEPLVVIAQPSLETPLLPSSNELENVMTSVQNKCYIQVSGMTCASCVANIERNLRREEGIYSVLVALMAGKAEVRYNPAVIQPRVIAEFIRELGFGA 545          

Query:  109 RMKVDGMTCMSCVRNIEENLMKFTGVCGIMVSLLHAEATVIFDADIATVEDISNKIDEMGFDVTVKSS---------EVSNVKDKVVRSR-------IKFESDIN----------KSVEKSIETSLSSKLLL--VRFCQENNYADIWHYSSIRSTEIL--------------SVIQQSEIYGVL------------VLEQCPTIRVIVRVNGMTCQSCVDNIESTVGKKQGIISIKVFLEKSEAHALVDASLAGPD-VEEMINDMGFNSEMILEIFNDSCAGKPNNVSQKYEEL----KSNTIYPILSTT-----IVIKALKSIFCIFKIENHMRALPGVDKCSVNLIEEIGMIDYDSGKWNVQKIREEIESLGYLTELPKQNWNSTRQSSAVSLNE-ESRSKCYLRITGMTCSSCVNKVESHLLKVEGVKSVLVALLAMKCEIIYDSAYVMPFQLSNRVKELGFNAEVIE 1326
            +MKV+GMTC SC   IE  + K  GV  I VSL + EAT++F   + T E+I  +I+ +GF   +K           +V  +K+  V+S          + SD            KS   +IE++LS+   +  +    EN  A + + +S+ + E+L              S+  + E                 ++ Q  T   ++ +NGMTC SCV +IE  + KK G+ SI V L  S      D  L  P+ + E I DMGF++ +  ++           ++Q   E      SN +  ++++      I +  +    C+  IE ++R   G+    V L+     + Y+      + I E I  LG+               + V  N  E      L + GMTC+SCV+K+ES L K +G+    VAL   K  I YD   + P  + + +  LGF A +++
Sbjct:  174 KMKVEGMTCHSCTSTIEGKVGKLQGVQRIKVSLDNQEATIVFQPHLITAEEIKKQIEAVGFPAFIKKQPKYLKLGAIDVERLKNTPVKSSEGSQQKSPSYPSDSTTMFTIEGMHCKSCVSNIESALSTLQYVSSIVVSLENRSAIVKYNASLVTPEMLRKAIEAISPGQYRVSIASEVESTASSPSSSSLQKMPLNIVSQPLTQEAVININGMTCNSCVQSIEGVISKKPGVKSIHVSLANSTGTIEFDPLLTSPETLREAIEDMGFDAALPADMKEPLVV-----IAQPSLETPLLPSSNELENVMTSVQNKCYIQVSGMTCASCVANIERNLRREEGIYSVLVALMAGKAEVRYNPAVIQPRVIAEFIRELGF--------------GAMVMENAGEGNGILELVVRGMTCASCVHKIESTLTKHKGIFYCSVALATNKAHIKYDPEIIGPRDIIHTIGSLGFEASLVK 625          

Query:  106 ARMKVDGMTCMSCVRNIEENLMKFTGVCGIMVSLLHAEATVIFDADIATVEDISNKIDEMGFDVTVKSSEVSNVKDKVVRSRIKFESDINKSVEKSIETSLSSKLLLVRFCQENNYADIWHYSSIRSTEILSVIQQSEIYGVLVLEQCPTIRVIVRVNGMTCQSCVDNIESTVGKKQGIISIKVFLEKSEAHALVDASLAGPDV-EEMINDMGFNSEMILEIFNDSCAGKPNNVSQKYEELKSNTIYPILSTTIVIKALKSIFCIFKIENHMRALPGVDKCSVNLIEEIGMIDYDSGKWNVQKIREEIESLGYLTELPKQNWNS 1074
            A + ++GMTC SCV++IE  + K  GV  I VSL ++  T+ FD  + + E +   I++MGFD                       +D+ + +    + SL + LL                SS     +++ +Q                +  ++V+GMTC SCV NIE  + +++GI S+ V L   +A    + ++  P V  E I ++GF + M++E      AG+ N + +                 +V++ +    C+ KIE+ +    G+  CSV L      I YD      + I   I SLG+   L K++ ++
Sbjct:  379 AVININGMTCNSCVQSIEGVISKKPGVKSIHVSLANSTGTIEFDPLLTSPETLREAIEDMGFDAA-------------------LPADMKEPLVVIAQPSLETPLL---------------PSSNELENVMTSVQN---------------KCYIQVSGMTCASCVANIERNLRREEGIYSVLVALMAGKAEVRYNPAVIQPRVIAEFIRELGFGA-MVME-----NAGEGNGILE-----------------LVVRGMTCASCVHKIESTLTKHKGIFYCSVALATNKAHIKYDPEIIGPRDIIHTIGSLGFEASLVKKDRSA 630          

Query: 1351 VNVLIRGMTCSSCVNHIENHISKIKGIASINVSLSTSKGKVEYFISECGPRDVIDAINDMGFDASL 1548
            + + + GMTC SCV  IE  I K+ G+  I VSL      + Y      P+ + +AI+DMGFDA L
Sbjct:   10 ITITVEGMTCISCVRTIEQQIGKVNGVHHIKVSLEEKSATIIYDPKLQTPKTLQEAIDDMGFDALL 75          

Query:  574 VNGMTCQSCVDNIESTVGKKQGIISIKVFLEKSEAHALVDASLAGPDVEEMINDMGFNSEMILEIFNDSCAGKPNNVSQKYEELKSNTIYPILSTTIVIK--ALKSIFCIFKIENHMRALPGVDKCSVNLIEEIGMIDYDSGKWNVQKIREEIESLGYLTELP--KQNWNSTRQSSA-----VSLNE------ESRSKCYLRITGMTCSSCVNKVESHLLKVEGVKSVLVALLAMKCEIIYDSAYVMPFQLSNRVKELGFNAEVIENGNEGIGIVNVLIRGMTCSSCVNHIENHISKIKGIASINVSLSTSKGKVEYFISECGPRDVIDAINDMGFDASLCDHLES-NHAAADHINQMIKQWRSSFFFSLICGIPXXXXXXXXXXXXXXXXHTIIHENGSNRTIMKSTVPM-----VCSGLSADNLILFVLATPVQFYGARYFYIQAYLSLKHKTTNMDVLVVMATXXXXXXXXXXXXXXMAFRRNTSPKTFFETSPMLIVFLSLGRWLEHIAKGKTSEALTKLMSLQAVEATLYT--PEN---KERKIPINLVQRNDLIKILPGEKIPVDGKVVTGTSTCDESLITGESMPIEKTHGSDVIGGSINKSGMLIVKATHVGSDSALAQIVKLVEEAQTSKAPIQQLADRIAGMFVPSVLICAIITLIIWVIVGFSKPEI----LPKYVNELSVTEITWEHAFQLAITVLSIACPCSLGLXXXXXXXXXXXXXXXNGILIKGGEPLENIHKLNVIVFDKTGTITNGSPSVTRFLVLI-GNGVREHIDKLLKILAAAESASEHPIGKAIITFSKARISNENLPEVLESSAVSGCGLGCKLNLDPKTEVTKFVKNLINIESPSEETNILGQXXXXXXXXXXXXTYKDVIFPVRQHMAWTSDLCQTVTVIIGNRNWMLRNGILVDDEVDELMSEDENLGRTVILMAIDNELIAMISVADQVKREAALAVYTLKKMNIEVYLMTGDNSKTATAIARQVGIHYVFAEVLPSHKVAKVQQLQNTNRSLTSKRKMKVAMVGDGINDSPALAQSDVGIAIGTGTDVAVEAADVVLIRNSLLDVIAAIQLSKATVKRIRQNFIAATLYNLLGIPIAAGVLMPIGIEMMPWMXXXXXXXXXXXXXXXXXXXXXWKKPSEEKLITPEYINFIQSSGLSESQIIVRRGID 4008
            + GM C+SCV NIES +   Q + SI V LE   A    +ASL  P++     +     +  + I ++  +   +  S   +++  N +   L+   VI    +    C+  IE  +   PGV    V+L    G I++D    + + +RE IE +G+   LP  K+      Q S       S NE        ++KCY++++GMTC+SCV  +E +L + EG+ SVLVAL+A K E+ Y+ A + P  ++  ++ELGF A V+EN  EG GI+ +++RGMTC+SCV+ IE+ ++K KGI   +V+L+T+K  ++Y     GPRD+I  I  +GF+ASL     S NH   DH  + IKQWR SF  SL   IP M +M++ M     +     ++N SN  ++     M     +  GLS  NL+  +L  PVQF G  YFYIQAY +LKHKT NMDVL+V+AT+I++ YS+++++++M  R   +P TFF+T PML VF++LGRWLEHIAKGKTSEAL KL+SLQA EAT+ T   EN    E ++ + LVQR D+IK++PG K PVDG+V+ G S  DESLITGE+MP+ K  GS VI GSIN++G L+++ATHVG+D+ L+QIVKLVEEAQTSKAPIQQ AD+++G FVP +++ +I+TL++W+I+GF   EI     P Y   +S TE     AFQ +ITVL IACPCSLGLATPTAVMVGTGVGA NGILIKGGEPLE  HK+ V+VFDKTGTIT+G+P V +  VL+  N +    +K+L I+  AES SEHP+G A+  + K  +  E L    +   V GCG+ CK        VT     L       EE NI   ++      + + +    +  +  H++   +  Q   V+IGNR WM+RNG+++ ++VDE M E E  GRT +L+ ID+EL  +I++AD VK EA LAV+ LK M +EV LMTGDNSKTA +IA QVGI  VFAEVLPSHKVAKV+QLQ   +        +VAMVGDGINDSPALA ++VGIAIGTGTDVA+EAADVVLIRN LLDV+A+I LS+ TVKRIR NF+ A +YNL+GIPIAAGV +PIG+ + PWM SAAMAASSVSVV  SL LKL++KP+ +     E      +   S S+I V  GID
Sbjct:  283 IEGMHCKSCVSNIESALSTLQYVSSIVVSLENRSAIVKYNASLVTPEMLRKAIEAISPGQYRVSIASEVESTASSPSSSSLQKMPLNIVSQPLTQEAVININGMTCNSCVQSIEGVISKKPGVKSIHVSLANSTGTIEFDPLLTSPETLREAIEDMGFDAALPDMKEPLVVIAQPSLETPLLPSSNELENVMTSVQNKCYIQVSGMTCASCVANIERNLRREEGIYSVLVALMAGKAEVRYNPAVIQPRVIAEFIRELGFGAMVMENAGEGNGILELVVRGMTCASCVHKIESTLTKHKGIFYCSVALATNKAHIKYDPEIIGPRDIIHTIGSLGFEASLVKKDRSANHL--DH-KREIKQWRGSFLVSLFFCIPVMGLMVYMMVMDHHLATLHHNQNMSNEEMINMHSAMFLERQILPGLSIMNLLSLLLCLPVQFCGGWYFYIQAYKALKHKTANMDVLIVLATTIAFAYSLVILLVAMFERAKVNPITFFDTPPMLFVFIALGRWLEHIAKGKTSEALAKLISLQATEATIVTLNSENLLLSEEQVDVELVQRGDIIKVVPGGKFPVDGRVIEGHSMVDESLITGEAMPVAKKPGSTVIAGSINQNGSLLIRATHVGADTTLSQIVKLVEEAQTSKAPIQQFADKLSGYFVPFIVLVSIVTLLVWIIIGFQNFEIVETYFPGYNRSISRTETIIRFAFQASITVLCIACPCSLGLATPTAVMVGTGVGAQNGILIKGGEPLEMAHKVKVVVFDKTGTITHGTPVVNQVKVLVESNKISR--NKILAIVGTAESNSEHPLGAAVTKYCKKELDTETLGTCTDFQVVPGCGISCK--------VTNIEGLLHKSNLKIEENNIKNASLVQIDAINEQSSTSSSMI-IDAHLSNAVN-TQQYKVLIGNREWMIRNGLVISNDVDESMIEHERRGRTAVLVTIDDELCGLIAIADTVKPEAELAVHILKSMGLEVVLMTGDNSKTARSIASQVGITKVFAEVLPSHKVAKVKQLQEEGK--------RVAMVGDGINDSPALAMANVGIAIGTGTDVAIEAADVVLIRNDLLDVVASIDLSRKTVKRIRINFVFALIYNLVGIPIAAGVFLPIGLVLQPWMGSAAMAASSVSVVLSSLFLKLYRKPTYDNY---ELHPRSHTGQRSPSEISVHVGID 1432          

Query:  103 SARMKVDGMTCMSCVRNIEENLMKFTGVCGIMVSLLHAEATVIFDADIATVEDISNKIDEMGFDVTVKSSE----VSNVKDKVVRSRIKFESDINKSVEKSIETSLSSKLLL-VRFCQENNYADIWHYSSIRS-TEILSVIQ--------QSEIYGVLVLEQCPT---IRVIVRVNGMTCQSCVDNIESTVGKKQGIISIKVFLEKSEAHALVDASL-AGPDVEEMINDMGFNSEM--------ILEIFNDSCAGKPNNVSQKYEELKSNTIYPILSTTI-VIKALKSIFCIFKIENHMRALPGVDKCSVNLIEEIGMIDYDSGKWNVQKIREEIESLG---YLTELPKQNWNSTRQSSAVSL--------NEESRSKCYLRITGMTCSSCVNKVESHLLKVEGVKSVLVALLAMKCEIIYDSAYVMPFQLSNRVKELGFNA-------------------EVIENGNEGIGIVN-------VLIRGMTCSSCVNHIENHISKIKGIASINVSLSTSKGKVEYFISECGPRDVIDAINDMGFDA 1542
            S  + V+GMTC+SCVR IE+ + K  GV  I VSL    AT+I+D  + T + +   ID+MGFD  + ++     ++N     V + +    D  +S      T L +K +  V+   +   A +    S+ S ++I+ ++         Q +  G       P    + + ++V GMTC SC   IE  VGK QG+  IKV L+  EA  +    L    ++++ I  +GF + +        +  I  +     P   S+  ++ KS + YP  STT+  I+ +    C+  IE+ +  L  V    V+L     ++ Y++     + +R+ IE++    Y   +  +  ++    S+ SL        ++    +  + I GMTC+SCV  +E  + K  GVKS+ V+L      I +D     P  L   ++++GF+A                    ++ + NE   ++        + + GMTC+SCV +IE ++ + +GI S+ V+L   K +V Y  +   PR + + I ++GF A
Sbjct:    9 SITITVEGMTCISCVRTIEQQIGKVNGVHHIKVSLEEKSATIIYDPKLQTPKTLQEAIDDMGFDALLHNANPLPVLTNTVFLTVTAPLTLPWDHIQS------TLLKTKGVTGVKISPQQRSAVVTIIPSVVSASQIVELVPDLSLDMGTQEKKSGACEEHSTPQAGEVMLKMKVEGMTCHSCTSTIEGKVGKLQGVQRIKVSLDNQEATIVFQPHLITAEEIKKQIEAVGFPAFIKKQPKYLKLGAIDVERLKNTPVKSSEGSQQ-KSPS-YPSDSTTMFTIEGMHCKSCVSNIESALSTLQYVSSIVVSLENRSAIVKYNASLVTPEMLRKAIEAISPGQYRVSIASEVESTASSPSSSSLQKMPLNIVSQPLTQEAVININGMTCNSCVQSIEGVISKKPGVKSIHVSLANSTGTIEFDPLLTSPETLREAIEDMGFDAALPDMKEPLVVIAQPSLETPLLPSSNELENVMTSVQNKCYIQVSGMTCASCVANIERNLRREEGIYSVLVALMAGKAEVRYNPAVIQPRVIAEFIRELGFGA 544          

Query:  109 RMKVDGMTCMSCVRNIEENLMKFTGVCGIMVSLLHAEATVIFDADIATVEDISNKIDEMGFDVTVKSS---------EVSNVKDKVVRSR-------IKFESDIN----------KSVEKSIETSLSSKLLL--VRFCQENNYADIWHYSSIRSTEIL--------------SVIQQSEIYGVL------------VLEQCPTIRVIVRVNGMTCQSCVDNIESTVGKKQGIISIKVFLEKSEAHALVDASLAGPD-VEEMINDMGFNS------EMILEIFNDSCAGKPNNVSQKYEELKS---NTIYPILSTTIVIKALKSIFCIFKIENHMRALPGVDKCSVNLIEEIGMIDYDSGKWNVQKIREEIESLGYLTELPKQNWNSTRQSSAVSLNE-ESRSKCYLRITGMTCSSCVNKVESHLLKVEGVKSVLVALLAMKCEIIYDSAYVMPFQLSNRVKELGFNAEVIE 1326
            +MKV+GMTC SC   IE  + K  GV  I VSL + EAT++F   + T E+I  +I+ +GF   +K           +V  +K+  V+S          + SD            KS   +IE++LS+   +  +    EN  A + + +S+ + E+L              S+  + E                 ++ Q  T   ++ +NGMTC SCV +IE  + KK G+ SI V L  S      D  L  P+ + E I DMGF++      E ++ I   S        S + E + +   N  Y      I +  +    C+  IE ++R   G+    V L+     + Y+      + I E I  LG+               + V  N  E      L + GMTC+SCV+K+ES L K +G+    VAL   K  I YD   + P  + + +  LGF A +++
Sbjct:  174 KMKVEGMTCHSCTSTIEGKVGKLQGVQRIKVSLDNQEATIVFQPHLITAEEIKKQIEAVGFPAFIKKQPKYLKLGAIDVERLKNTPVKSSEGSQQKSPSYPSDSTTMFTIEGMHCKSCVSNIESALSTLQYVSSIVVSLENRSAIVKYNASLVTPEMLRKAIEAISPGQYRVSIASEVESTASSPSSSSLQKMPLNIVSQPLTQEAVININGMTCNSCVQSIEGVISKKPGVKSIHVSLANSTGTIEFDPLLTSPETLREAIEDMGFDAALPDMKEPLVVIAQPSLETPLLPSSNELENVMTSVQNKCY------IQVSGMTCASCVANIERNLRREEGIYSVLVALMAGKAEVRYNPAVIQPRVIAEFIRELGF--------------GAMVMENAGEGNGILELVVRGMTCASCVHKIESTLTKHKGIFYCSVALATNKAHIKYDPEIIGPRDIIHTIGSLGFEASLVK 624          

Query:  106 ARMKVDGMTCMSCVRNIEENLMKFTGVCGIMVSLLHAEATVIFDADIATVEDISNKIDEMGFDVTVKSSEVSNVKDKVVRSRIKFESDINKSVEKSIETSLSSKLLLVRFCQENNYADIWHYSSIRSTEILSVIQQSEIYGVLVLEQCPTIRVIVRVNGMTCQSCVDNIESTVGKKQGIISIKVFLEKSEAHALVDASLAGPDV-EEMINDMGFNSEMILEIFNDSCAGKPNNVSQKYEELKSNTIYPILSTTIVIKALKSIFCIFKIENHMRALPGVDKCSVNLIEEIGMIDYDSGKWNVQKIREEIESLGYLTELPKQNWNS 1074
            A + ++GMTC SCV++IE  + K  GV  I VSL ++  T+ FD  + + E +   I++MGFD  +                     D+ + +    + SL + LL                SS     +++ +Q                +  ++V+GMTC SCV NIE  + +++GI S+ V L   +A    + ++  P V  E I ++GF + M++E      AG+ N + +                 +V++ +    C+ KIE+ +    G+  CSV L      I YD      + I   I SLG+   L K++ ++
Sbjct:  379 AVININGMTCNSCVQSIEGVISKKPGVKSIHVSLANSTGTIEFDPLLTSPETLREAIEDMGFDAAL--------------------PDMKEPLVVIAQPSLETPLL---------------PSSNELENVMTSVQN---------------KCYIQVSGMTCASCVANIERNLRREEGIYSVLVALMAGKAEVRYNPAVIQPRVIAEFIRELGFGA-MVME-----NAGEGNGILE-----------------LVVRGMTCASCVHKIESTLTKHKGIFYCSVALATNKAHIKYDPEIIGPRDIIHTIGSLGFEASLVKKDRSA 629          

Query: 1351 VNVLIRGMTCSSCVNHIENHISKIKGIASINVSLSTSKGKVEYFISECGPRDVIDAINDMGFDASL 1548
            + + + GMTC SCV  IE  I K+ G+  I VSL      + Y      P+ + +AI+DMGFDA L
Sbjct:   10 ITITVEGMTCISCVRTIEQQIGKVNGVHHIKVSLEEKSATIIYDPKLQTPKTLQEAIDDMGFDALL 75          

Query:  562 VIVRVNGMTCQSCVDNIESTVGKKQGIISIKVFLEKSEAHALVDASLAGP-DVEEMINDMGFNSEMILEIFNDSCAGK--PNNVSQ-KYEELKSNTIYPI-LSTTIVIKALKSIFCI---FKIENHMRALP---GVDKCSVNLIEEIGMIDYDSGKWNVQKIREEIESLGY--------LTELPKQNW---NSTRQS------SAVSLNEESRS-----------------------KCYLRITGMTCSSCVNKVESHLLKVEGVKSVLVALLAMKCEIIYDSAYVMPFQLSNRVKELGFNAEVIENGNEGIGIVNVLIRGMTCSSCVNHIENHISKIKGIASINVSLSTSKGKVEYFISECGPRDVIDAINDMGFDASLCDHLESNHAAADHINQMIKQWRSSFFFSLICGIPXXXXXXXXXXXXXXXXHTIIHENGSNRTIMKSTVPMVCSGLSADNLILFVLATPVQFYGARYFYIQAYLSLKHKTTNMDVLVVMATXXXXXXXXXXXXXXMAFRRNTSPKTFFETSPMLIVFLSLGRWLEHIAKGKTSEALTKLMSLQAVEATLYT--PEN---KERKIPINLVQRNDLIKILPGEKIPVDGKVVTGTSTCDESLITGESMPIEKTHGSDVIGGSINKSGMLIVKATHVGSDSALAQIVKLVEEAQTSKAPIQQLADRIAGMFVPSVLICAIITLIIWVIVGFSKPEILPKYV----NELSVTEITWEHAFQLAITVLSIACPCSLGLXXXXXXXXXXXXXXXNGILIKGGEPLENIHKLNVIVFDKTGTITNGSPSVTRFLVLIGNGVREHIDKLLKILAAAESASEHPIGKAIITFSKARISNENLPEVLESSAVSGCGLGCKL-NLDPKTEVTKFVKNLINIESPSEETNILGQXXXXXXXXXXXXTYKDVIFPVRQHMAWTSDLCQTVTVIIGNRNWMLRNGILVDDEVDELMSEDENLGRTVILMAIDNELIAMISVADQVKREAALAVYTLKKMNIEVYLMTGDNSKTATAIARQVGIHYVFAEVLPSHKVAKVQQLQNTNRSLTSKRKMKVAMVGDGINDSPALAQSDVGIAIGTGTDVAVEAADVVLIRNSLLDVIAAIQLSKATVKRIRQNFIAATLYNLLGIPIAAGVLMPIGIEMMPWMXXXXXXXXXXXXXXXXXXXXXWKKPSEEKLITPEYINFIQSSGLSESQIIVRRGID 4008
            V +RV GMTCQSCV +IE  + K QG++ IKV L   EA       L  P D+ + I DMGF +     I N +   +  P +V++ +   LK  T+ P+ +S        +  +      +I+     L    GV + S++L E  G + YD    ++ ++R  +E +G+         T  P +N+   NS  Q+      S   +  ++R                        KC+++I GMTC+SCV+ +E  L +  G+ SVLVAL++ K E+ YD   +   +++  +++LGF A V+E+     G + ++I GMTC+SCV++IE+ +++  GI   +V+L+TSK  V++     GPRD+I  I ++GF ASL     + H   DH  + IKQW+ SF  SL+ GIP M +M++ +      + T++ ++             +  GLS  NLI F+L T VQF G  YFY+QAY SL+H++ NMDVL+V+AT+I+Y YS++++V+++A +   SP TFF+T PML VF++LGRWLEH+AK KTSEAL KLMSLQA EAT+ T   +N   +E ++P+ LVQR D+IK++PG K PVDGKV+ G +  DESLITGE+MP+ K  GS VI GSIN  G +++KATHVG+D+ LAQIVKLVEEAQ SKAPIQQLADR +G FVP ++I + +TL++W+++GF    ++ KY       +S TE+    AFQ +ITVL IACPCSLGLATPTAVMVGTGV A NG+LIKGG+PLE  HK+  ++FDKTGTIT+G P V RFL L+ +     + K+L ++  AE++SEHP+G A+  + K  +  E L    +  AV GCG+ CK+ N++     +    + + + +P                            P  +         QT +V+IGNR WM RNG+ +  ++ + M++ E  G+T IL+AID  L  MI++AD VK EAALA+YTLK M ++V L+TGDN KTA AIA QVGI+ VFAEVLPSHKVAKVQ+LQN  +        KVAMVGDG+NDSPALAQ+DVGIAIGTGTDVA+EAADVVLIRN LLDV+A+I LSK TV+RIR N + A +YN++GIPIAAGV MPIGI + PWM SAAMAASSVSVV  SL LK ++KP  E+    E     +   LS SQ+ V  G+D
Sbjct:  143 VKLRVEGMTCQSCVSSIEGKIRKLQGVVRIKVSLSNQEAVITYQPYLIQPEDLRDHICDMGFEAA----IKNRTAPLRLGPIDVNKLESTNLKKETVSPVQISNHFETLGHQGSYLATLPLRIDGMHYMLSQRKGVQQTSISLAEGTGAVLYDPSIVSLDELRTAVEDMGFEVSVNSETFTINPVRNFKSGNSVPQTMGDIAGSVQKMAPDTRGLPTHQGPGHSSETPSSPGATASQKCFVQIKGMTCASCVSNIERSLQRHAGILSVLVALMSGKAEVKYDPEIIQSPRIAQLIQDLGFEASVMEDNTVSEGDIELIITGMTCASCVHNIESKLTRTNGITYASVALATSKAHVKFDPEIVGPRDIIKIIEEIGFHASLAQRNPNAHHL-DHKTE-IKQWKKSFLCSLVFGIPVMGLMVYMLIPSSTPQETMVLDHN------------IIPGLSVLNLIFFILCTFVQFLGGWYFYVQAYKSLRHRSANMDVLIVLATTIAYAYSLVILVVAVAEKAEKSPVTFFDTPPMLFVFIALGRWLEHVAKSKTSEALAKLMSLQATEATVVTLGEDNLILREEQVPMELVQRGDVIKVVPGGKFPVDGKVLEGNTMADESLITGEAMPVTKKPGSIVIAGSINAHGSVLLKATHVGNDTTLAQIVKLVEEAQMSKAPIQQLADRFSGYFVPFIIIISTLTLVVWIVIGFVDFGVVQKYFPSPSKHISQTEVIIRFAFQTSITVLCIACPCSLGLATPTAVMVGTGVAAQNGVLIKGGKPLEMAHKIKTVMFDKTGTITHGVPRVMRFL-LLADVATLPLRKVLAVVGTAEASSEHPLGVAVTKYCKEELGTETLGYSTDFQAVPGCGISCKVSNVEGILARSDLTAHPVGVGNP----------------------------PTGEGAG-----PQTFSVLIGNREWMRRNGLTISSDISDAMTDHEMKGQTAILVAIDGVLCGMIAIADAVKPEAALAIYTLKSMGVDVALITGDNRKTARAIATQVGINKVFAEVLPSHKVAKVQELQNEGK--------KVAMVGDGVNDSPALAQADVGIAIGTGTDVAIEAADVVLIRNDLLDVVASIHLSKRTVRRIRVNLVLALIYNMVGIPIAAGVFMPIGIVLQPWMGSAAMAASSVSVVLSSLQLKCYRKPDLERY---EAQAHGRMKPLSASQVSVHIGMD 1289          

Query:  109 RMKVDGMTCMSCVRNIEENLMKFTGVCGIMVSLLHAEATVIFDADIATVEDISNKIDEMGFDVTVKSSEVSNVKDKVVRSRIKFESDINKSVEKSIETSLSSKLLLVRFCQENNYADIWHYSSIRSTEILSVIQQSEIYGVLVLEQCPTIRVIVRVNGMTCQSCVDNIESTVGKKQGIISIKVFLEKSEAHALVDASLAGPD-VEEMINDMGFNSEMILEIF----------NDSCAGKPNNVSQKYEELKSNT----------------IYPILSTT----IVIKALKSIFCIFKIENHMRALPGVDKCSVNLIEEIGMIDYDSGKWNVQKIREEIESLGYLTELPKQNWNSTRQSSAVSLNEESRSKCYLRITGMTCSSCVNKVESHLLKVEGVKSVLVALLAMKCEIIYDSAYVMPFQLSNRVKELGFNAEVIEN 1329
            +++V+GMTC SCV +IE  + K  GV  I VSL + EA + +   +   ED+ + I +MGF+        + +K++    R+    D+NK    +++    S + +      N++  + H  S  +T                        + +R++GM            + +++G+    + L +     L D S+   D +   + DMGF   +  E F           +S      +++   +++  +T                  P  + +    + IK +    C+  IE  ++   G+    V L+     + YD       +I + I+ LG+             ++S +  N  S     L ITGMTC+SCV+ +ES L +  G+    VAL   K  + +D   V P  +   ++E+GF+A + + 
Sbjct:  144 KLRVEGMTCQSCVSSIEGKIRKLQGVVRIKVSLSNQEAVITYQPYLIQPEDLRDHICDMGFE--------AAIKNRTAPLRLG-PIDVNKLESTNLKKETVSPVQI-----SNHFETLGHQGSYLAT------------------------LPLRIDGM---------HYMLSQRKGVQQTSISLAEGTGAVLYDPSIVSLDELRTAVEDMGFEVSVNSETFTINPVRNFKSGNSVPQTMGDIAGSVQKMAPDTRGLPTHQGPGHSSETPSSPGATASQKCFVQIKGMTCASCVSNIERSLQRHAGILSVLVALMSGKAEVKYDPEIIQSPRIAQLIQDLGF-------------EASVMEDNTVSEGDIELIITGMTCASCVHNIESKLTRTNGITYASVALATSKAHVKFDPEIVGPRDIIKIIEEIGFHASLAQR 521          

Query: 1051 LPKQNW-NSTRQSSAV-------SLNEESRSKC---YLRITGMTCSSCVNKVESHLLKVEGVKSVLVALLAMKCEIIYDSAYVMPFQLSNRVKELGFNAEVIENGNEGI---------GIVNVLIRGMTCSSCVNHIENHISKIKGIASINVSLSTSKGKVEYFISECGPRDVIDAINDMGFDASL 1548
            LP + W  S +QS A         L+  S S      + I GMTC SCV  +E  +  ++G+ ++ V+L      + Y  + +   Q+  +++++GF A   E                +V + + GMTC SCV+ IE  I K++G+  I VSLS  +  + Y      P D+ D I DMGF+A++
Sbjct:   23 LPGRPWEQSMKQSFAFDNVGYEGGLDSTSSSPAATDVVNILGMTCHSCVKSIEDRISSLKGIVNIKVSLEQGSATVRYVPSVMNLQQICLQIEDMGFEASAAEGKAASWPSRSSPAQEAVVKLRVEGMTCQSCVSSIEGKIRKLQGVVRIKVSLSNQEAVITYQPYLIQPEDLRDHICDMGFEAAI 208          

Query:  550 PTIRVIVRVNGMTCQSCVDNIESTVGKKQGIISIKVFLEKSEAHA-LVDASLAGPDVEEMINDMGFNSEMILEIFNDSCAGKPNNVSQKYEELKSNTIYPILSTTIVIKALKSIFCIFKIENHMRALPGVDKCSVNLIEEIGMIDYDSGKWNVQKIREEIESLGYLTELPKQNWNSTRQSSAVSLN--------EESRSKC----YLRITGMTCSSC------VNKVESHLLKVEGVKSVLVALLAMKCEIIYDSAYVMPFQLSNRVKELGFNAEV------------IENGN--------------------------EGIGIVN---------------VLIRGMTCSSCVNHIENHISKIKGIASINVSLSTSKGKVEYFISECGPRDVIDAINDMGFDASLCD 1554
            P    +V + GMTC SCV +IE  +   +GI++IKV LE+  A    V + +    +   I DMGF +           A  P+  S   E +            + ++ +    C+  IE  +R L GV +  V+L  +  +I Y       + +R+ I  +G+  E   +N  +  +   + +N        +E+ S      +    G   S        ++ +   L + +GV+   ++L      ++YD + V   +L   V+++GF   V             ++GN                          +G G  +               V I+GMTC+SCV++IE  + +  GI S+ V+L + K +V+Y         +   I D+GF+AS+ +
Sbjct:   54 PAATDVVNILGMTCHSCVKSIEDRISSLKGIVNIKVSLEQGSATVRYVPSVMNLQQICLQIEDMGFEASAA----EGKAASWPSRSSPAQEAV----------VKLRVEGMTCQSCVSSIEGKIRKLQGVVRIKVSLSNQEAVITYQPYLIQPEDLRDHICDMGF--EAAIKNRTAPLRLGPIDVNKLESTNLKKETVSPVQISNHFETLGHQGSYLATLPLRIDGMHYMLSQRKGVQQTSISLAEGTGAVLYDPSIVSLDELRTAVEDMGFEVSVNSETFTINPVRNFKSGNSVPQTMGDIAGSVQKMAPDTRGLPTHQGPGHSSETPSSPGATASQKCFVQIKGMTCASCVSNIERSLQRHAGILSVLVALMSGKAEVKYDPEIIQSPRIAQLIQDLGFEASVME 444          

Query:   97 LGSARMKVDGMTCMSCVRNIEENLMKFTGVCGIMVSLLHAEATVIFDADIATVEDISNKIDEMGFDVTVKS-----SEVSNVKDKVVRSRIKFESDINKSVEKSIETSLSSKLLLVRFCQENNYADIWHYSSIRSTEILSVIQQSEIYGVLVLEQCPTIRVIVRVNGMTCQSCVDNIESTVGKKQGIISIKVFLEKSEAHALVDAS-LAGPDVEEMINDMGFNSEMILEIFNDSCAGKPNNVSQKYEELKSNTIYPILSTTIVIKALKSIFCIFKIENHMRALPGVDKCSVNLIEEIGMIDYDSGKWNVQKIREEIESLGYLTELPKQNWNS 1074
            L +  +++DGM  M         L +  GV    +SL      V++D  I +++++   +++MGF+V+V S     + V N K     S  +   DI  SV+K                  +      H     S+E  S        G    ++C      V++ GMTC SCV NIE ++ +  GI+S+ V L   +A    D   +  P + ++I D+GF + ++ +          N VS+   EL             +I  +    C+  IE+ +    G+   SV L      + +D      + I + IE +G+   L ++N N+
Sbjct:  254 LATLPLRIDGMHYM---------LSQRKGVQQTSISLAEGTGAVLYDPSIVSLDELRTAVEDMGFEVSVNSETFTINPVRNFKSG--NSVPQTMGDIAGSVQK---------------MAPDTRGLPTHQGPGHSSETPSS------PGATASQKC-----FVQIKGMTCASCVSNIERSLQRHAGILSVLVALMSGKAEVKYDPEIIQSPRIAQLIQDLGFEASVMED----------NTVSEGDIEL-------------IITGMTCASCVHNIESKLTRTNGITYASVALATSKAHVKFDPEIVGPRDIIKIIEEIGFHASLAQRNPNA 525          

Query: 3307 DNELIAMISVADQVKREAALAVYTLKKMNIEVYLMTGDNSKTATAIARQVGIH-------------------------------YVFAEVLPSHKVAKVQQLQNTNRSLTSKRKMKVAMVGDGINDSPALAQSDVGIAIGTGTDVAVEAADVVLIRNSLLDVIAAIQLSKATVKRIRQ-----------NFIAATLYNLLGIPIAAGVLMPI 3816
            D   +  + + D  + E A  +    +  I V ++TGDN  TA AI R++GI                                  FA V P+HK   V+ LQ+ N           AM GDG+ND+PAL ++++GIA+G+GT VA  AA++VL  ++   ++AA++  +A    ++Q             +   L  +LG+P A   L+P+
Sbjct:  590 DLTFVGCVGMLDPPRPEVAACITRCSRAGIRVVMITGDNKGTAVAICRRLGIFGDTEDVLGKAYTGREFDDLSPEQQRQACRTARCFARVEPAHKSRIVENLQSFNEI--------TAMTGDGVNDAPALKKAEIGIAMGSGTAVAKSAAEMVLSDDNFASIVAAVEEGRAIYNNMKQFIRYLISSNVGEVVCIFLTAILGLPEA---LIPV 790          

Query:  109 RMKVDGMTCMSCVRNIEENLMKFTGVCGIMVSLLHAEATVIFDADIATVEDISNKIDEMGFDVTVKSSEVSNVKDKVVRSRIKFESDINKSVEKSIETSLSSKLLLVRFCQENNYADIWHYSSIRSTEILSVIQQSEIYGVLVLEQCPTIRVIVRVNGMTCQSCVDNIESTVGKKQGIISIKVFLEKSEAHALVDASLAGPDVEEMINDMGFNSEMILEIFNDSCAGKPNN-VSQKYEELKSNTIYPILSTTIVIKALKSIFCIFKIENHMRALPGVDKCSVNLIEEIGMIDYDSGKWNVQKIREEIESLGY--------LTELPKQNW---NSTRQS------SAVSLNEESRS-----------------------KCYLRITGMTCSSCVNKVESHLLKVEGVKSVLVALLAMKCEIIYDSAYVMPFQLSNRVKELGFNAEVIENGNEGIGIVNVLIRGMTCSSCVNHIENHISKIKGIASINVSLSTSKGKVEYFISECGPRDVIDAINDMGFDASLCDHLESNHAAADHINQMIKQWRSSFFFSLICGIPXXXXXXXXXXXXXXXXHTIIHENGSNRTIMKSTVPMVCSGLSADNLILFVLATPVQFYGARYFYIQAYLSLKHKTTNMDVLVVMATXXXXXXXXXXXXXXMAFRRNTSPKTFFETSPMLIVFLSLGRWLEHIAKGKTSEALTKLMSLQAVEATLYT--PEN---KERKIPINLVQRNDLIKILPGEKIPVDGKVVTGTSTCDESLITGESMPIEKTHGSDVIGGSINKSGMLIVKATHVGSDSALAQIVKLVEEAQTSKAPIQQLADRIAGMFVPSVLICAIITLIIWVIVGFSKPEILPKYV----NELSVTEITWEHAFQLAITVLSIACPCSLGLXXXXXXXXXXXXXXXNGILIKGGEPLENIHKLNVIVFDKTGTITNGSPSVTRFLVLIGNGVREHIDKLLKILAAAESASEHPIGKAIITFSKARISNENLPEVLESSAVSGCGLGCKL-NLDPKTEVTKFVKNLINIESPSEETNILGQXXXXXXXXXXXXTYKDVIFPVRQHMAWTSDLCQTVTVIIGNRNWMLRNGILVDDEVDELMSEDENLGRTVILMAIDNELIAMISVADQVKREAALAVYTLKKMNIEVYLMTGDNSKTATAIARQVGIHYVFAEVLPSHKVAKVQQLQNTNRSLTSKRKMKVAMVGDGINDSPALAQSDVGIAIGTGTDVAVEAADVVLIRNSLLDVIAAIQLSKATVKRIRQNFIAATLYNLLGIPIAAGVLMPIGIEMMPWMXXXXXXXXXXXXXXXXXXXXXWKKPSEEKLITPEYINFIQSSGLSESQIIVRRGID 4008
            +++V+GMTC SCV +IE  + K  GV  I VSL + EA + +   +   ED+ + I +MGF+        + +K++    R+    D+NK    +++    S + +      N++  + H  S  +T                        + +R++GM C+SCV NIE  +G+  G+ +I V LE   A    D S   P   +   +        + + +     +P +  SQ+++E       P  +  + I  +     +  IE+ +    GV + S++L E  G + YD    ++ ++R  +E +G+         T  P +N+   NS  Q+      S   +  ++R                        KC+++I GMTC+SCV+ +E  L +  G+ SVLVAL++ K E+ YD   +   +++  +++LGF A V+E+     G + ++I GMTC+SCV++IE+ +++  GI   +V+L+TSK  V++     GPRD+I  I ++GF ASL     + H   DH  + IKQW+ SF  SL+ GIP M +M++ +      + T++ ++             +  GLS  NLI F+L T VQF G  YFY+QAY SL+H++ NMDVL+V+AT+I+Y YS++++V+++A +   SP TFF+T PML VF++LGRWLEH+AK KTSEAL KLMSLQA EAT+ T   +N   +E ++P+ LVQR D+IK++PG K PVDGKV+ G +  DESLITGE+MP+ K  GS VI GSIN  G +++KATHVG+D+ LAQIVKLVEEAQ SKAPIQQLADR +G FVP ++I + +TL++W+++GF    ++ KY       +S TE+    AFQ +ITVL IACPCSLGLATPTAVMVGTGV A NG+LIKGG+PLE  HK+  ++FDKTGTIT+G P V RFL L+ +     + K+L ++  AE++SEHP+G A+  + K  +  E L    +  AV GCG+ CK+ N++     +    + + + +P                            P  +         QT +V+IGNR WM RNG+ +  ++ + M++ E  G+T IL+AID  L  MI++AD VK EAALA+YTLK M ++V L+TGDN KTA AIA QVGI+ VFAEVLPSHKVAKVQ+LQN  +        KVAMVGDG+NDSPALAQ+DVGIAIGTGTDVA+EAADVVLIRN LLDV+A+I LSK TV+RIR N + A +YN++GIPIAAGV MPIGI + PWM SAAMAASSVSVV  SL LK ++KP  E+    E     +   LS SQ+ V  G+D
Sbjct:  156 KLRVEGMTCQSCVSSIEGKIRKLQGVVRIKVSLSNQEAVITYQPYLIQPEDLRDHICDMGFE--------AAIKNRTAPLRLG-PIDVNKLESTNLKKETVSPVQI-----SNHFETLGHQGSYLAT------------------------LPLRIDGMHCKSCVLNIEGNIGQLPGVQNIHVSLENKTAQIQYDPSCVTPMFLQTAIEALPPGHFKVSLPDGVEENEPQSGSSQRHQEQG-----PGRTAVLTISGITCASSVQPIEDMLSQRKGVQQTSISLAEGTGAVLYDPSIVSLDELRTAVEDMGFEVSVNSETFTINPVRNFKSGNSVPQTMGDIAGSVQKMAPDTRGLPTHQGPGHSSETPSSPGATASQKCFVQIKGMTCASCVSNIERSLQRHAGILSVLVALMSGKAEVKYDPEIIQSPRIAQLIQDLGFEASVMEDNTVSEGDIELIITGMTCASCVHNIESKLTRTNGITYASVALATSKAHVKFDPEIVGPRDIIKIIEEIGFHASLAQRNPNAHHL-DHKTE-IKQWKKSFLCSLVFGIPVMGLMVYMLIPSSTPQETMVLDHN------------IIPGLSVLNLIFFILCTFVQFLGGWYFYVQAYKSLRHRSANMDVLIVLATTIAYAYSLVILVVAVAEKAEKSPVTFFDTPPMLFVFIALGRWLEHVAKSKTSEALAKLMSLQATEATVVTLGEDNLILREEQVPMELVQRGDVIKVVPGGKFPVDGKVLEGNTMADESLITGEAMPVTKKPGSIVIAGSINAHGSVLLKATHVGNDTTLAQIVKLVEEAQMSKAPIQQLADRFSGYFVPFIIIISTLTLVVWIVIGFVDFGVVQKYFPSPSKHISQTEVIIRFAFQTSITVLCIACPCSLGLATPTAVMVGTGVAAQNGVLIKGGKPLEMAHKIKTVMFDKTGTITHGVPRVMRFL-LLADVATLPLRKVLAVVGTAEASSEHPLGVAVTKYCKEELGTETLGYSTDFQAVPGCGISCKVSNVEGILARSDLTAHPVGVGNP----------------------------PTGEGAG-----PQTFSVLIGNREWMRRNGLTISSDISDAMTDHEMKGQTAILVAIDGVLCGMIAIADAVKPEAALAIYTLKSMGVDVALITGDNRKTARAIATQVGINKVFAEVLPSHKVAKVQELQNEGK--------KVAMVGDGVNDSPALAQADVGIAIGTGTDVAIEAADVVLIRNDLLDVVASIHLSKRTVRRIRVNLVLALIYNMVGIPIAAGVFMPIGIVLQPWMGSAAMAASSVSVVLSSLQLKCYRKPDLERY---EAQAHGRMKPLSASQVSVHIGMD 1404          

Query:  562 VIVRVNGMTCQSCVDNIESTVGKKQGIISIKVFLEKSEAHALVDASLAGP-DVEEMINDMGFNSEM---------------ILEIFN-DSCAGKPNNVSQKYEELKSNTIYPILSTTIVIKALKSIFCIFKIENHMRALPGVDKCSVNLIEEIGMIDYDSGKWNVQKIREEIESLG---YLTELPKQNWNSTRQSSAVSLNEESRS--KCYLRITGMTCSSCVNKVESHLLKVEGVKSVLVALLAMKCEIIYDSAYVMPFQLSNRVKELGFNAEV------------IENGN--------------------------EGIGIVN---------------VLIRGMTCSSCVNHIENHISKIKGIASINVSLSTSKGKVEYFISECGPRDVIDAINDMGFDASLCD 1554
            V +RV GMTCQSCV +IE  + K QG++ IKV L   EA       L  P D+ + I DMGF + +                LE  N       P  +S  +E L     Y + +  + I  +    C+  IE ++  LPGV    V+L  +   I YD        ++  IE+L    +   LP     +  QS +   ++E        L I+G+TC+S V  +E  L + +GV+   ++L      ++YD + V   +L   V+++GF   V             ++GN                          +G G  +               V I+GMTC+SCV++IE  + +  GI S+ V+L + K +V+Y         +   I D+GF+AS+ +
Sbjct:  155 VKLRVEGMTCQSCVSSIEGKIRKLQGVVRIKVSLSNQEAVITYQPYLIQPEDLRDHICDMGFEAAIKNRTAPLRLGPIDVNKLESTNLKKETVSPVQISNHFETLGHQGSY-LATLPLRIDGMHCKSCVLNIEGNIGQLPGVQNIHVSLENKTAQIQYDPSCVTPMFLQTAIEALPPGHFKVSLPDGVEENEPQSGSSQRHQEQGPGRTAVLTISGITCASSVQPIEDMLSQRKGVQQTSISLAEGTGAVLYDPSIVSLDELRTAVEDMGFEVSVNSETFTINPVRNFKSGNSVPQTMGDIAGSVQKMAPDTRGLPTHQGPGHSSETPSSPGATASQKCFVQIKGMTCASCVSNIERSLQRHAGILSVLVALMSGKAEVKYDPEIIQSPRIAQLIQDLGFEASVME 559          

Query:  550 PTIRVIVRVNGMTCQSCVDNIESTVGKKQGIISIKVFLEKSEAHA-LVDASLAGPDVEEMINDMGFNSEMILEIFNDSCAGKPNNVSQKYEELKSNTIYPILSTTIVIKALKSIFCIFKIENHMRALPGVDKCSVNLIEEIGMIDYDSGKWNVQKIREEIESLGYLTELPKQNWNSTRQSSAVSLN--------EESRSKCY-------------------LRITGMTCSSCVNKVESHLLKVEGVKSVLVALLAMKCEIIYDSAYVMPFQLSNRVKEL-----------GFNAEVIENGN------EGIGIVNVL-IRGMTCSSCVNHIENHISKIKGIASINVSLSTSKGKVEYFISECGPRDVIDAINDMGFDASL 1548
            P    +V + GMTC SCV +IE  +   +GI++IKV LE+  A    V + +    +   I DMGF +           A  P+  S   E +            + ++ +    C+  IE  +R L GV +  V+L  +  +I Y       + +R+ I  +G+  E   +N  +  +   + +N        +E+ S                      LRI GM C SCV  +E ++ ++ GV+++ V+L     +I YD + V P  L   ++ L           G      ++G+      +G G   VL I G+TC+S V  IE+ +S+ KG+   ++SL+   G V Y  S     ++  A+ DMGF+ S+
Sbjct:   66 PAATDVVNILGMTCHSCVKSIEDRISSLKGIVNIKVSLEQGSATVRYVPSVMNLQQICLQIEDMGFEASAA----EGKAASWPSRSSPAQEAV----------VKLRVEGMTCQSCVSSIEGKIRKLQGVVRIKVSLSNQEAVITYQPYLIQPEDLRDHICDMGF--EAAIKNRTAPLRLGPIDVNKLESTNLKKETVSPVQISNHFETLGHQGSYLATLPLRIDGMHCKSCVLNIEGNIGQLPGVQNIHVSLENKTAQIQYDPSCVTPMFLQTAIEALPPGHFKVSLPDGVEENEPQSGSSQRHQEQGPGRTAVLTISGITCASSVQPIEDMLSQRKGVQQTSISLAEGTGAVLYDPSIVSLDELRTAVEDMGFEVSV 428          

Query: 1051 LPKQNW-NSTRQSSAV-------SLNEESRSKC---YLRITGMTCSSCVNKVESHLLKVEGVKSVLVALLAMKCEIIYDSAYVMPFQLSNRVKELGFNAEVIENGNEGI---------GIVNVLIRGMTCSSCVNHIENHISKIKGIASINVSLSTSKGKVEYFISECGPRDVIDAINDMGFDASL 1548
            LP + W  S +QS A         L+  S S      + I GMTC SCV  +E  +  ++G+ ++ V+L      + Y  + +   Q+  +++++GF A   E                +V + + GMTC SCV+ IE  I K++G+  I VSLS  +  + Y      P D+ D I DMGF+A++
Sbjct:   35 LPGRPWEQSMKQSFAFDNVGYEGGLDSTSSSPAATDVVNILGMTCHSCVKSIEDRISSLKGIVNIKVSLEQGSATVRYVPSVMNLQQICLQIEDMGFEASAAEGKAASWPSRSSPAQEAVVKLRVEGMTCQSCVSSIEGKIRKLQGVVRIKVSLSNQEAVITYQPYLIQPEDLRDHICDMGFEAAI 220          

Query: 1348 IVNVLIRGMTCSSCVNHIENHISKIKGIASINVSLSTSKGKVEYFISECGPRDVIDAINDMGFDASLCD 1554
            +VN+L  GMTC SCV  IE+ IS +KGI +I VSL      V Y  S    + +   I DMGF+AS  +
Sbjct:   71 VVNIL--GMTCHSCVKSIEDRISSLKGIVNIKVSLEQGSATVRYVPSVMNLQQICLQIEDMGFEASAAE 137          

Query:  109 RMKVDGMTCMSCVRNIEENLMKFTGVCGIMVSLLHAEATVIFDADIATVEDISNKIDEMGFDVTVKSSEVSNVKDKVVRSRIKFESDINKSVEKSIETSLSSKLLLVRFCQENNYADIWHYSSIRSTEILSVIQQSEIYGVLVLEQCPTIRVIVRVNGMTCQSCVDNIESTVGKKQGIISIKVFLEKSEAHALVDASLAGP-DVEEMINDMGFNSEMILEIFNDSCAGKPNN----VSQKYEELKSNTIYPILSTTIV-IKALKSIFCIFKIENHMRALPGVDKCSVNLIEEIGMIDYDSGKWNVQKIREEIESLGY----------------------------------------LTELPKQNWNSTRQSSAVSLNEESRSKCYLRITGMTCSSCVNKVESHLLKVEGVKSVLVALLAMKCEIIYDSAYVMPFQLSNRVKELGFNAEVIENGNEGIGIVNVLIRGMTCSSCVNHIENHISKIKGIASINVSLSTSKGKVEYFISECGPRDVIDAINDMGFDASLCDHLESNHAAADHINQMIKQWRSSFFFSLICGIPXXXXXXXXXXXXXXXXHTIIHENGSNRTIM--KSTVPMVCSGLSADNLILFVLATPVQFYGARYFYIQAYLSLKHKTTNMDVLVVMATXXXXXXXXXXXXXXMAFRRNTSPKTFFETSPMLIVFLSLGRWLEHIAKGKTSEALTKLMSLQAVEATLYT--PEN---KERKIPINLVQRNDLIKILPGEKIPVDGKVVTGTSTCDESLITGESMPIEKTHGSDVIGGSINKSGMLIVKATHVGSDSALAQIVKLVEEAQTSKAPIQQLADRIAGMFVPSVLICAIITLIIWVIVGFSKPEILPKYV----NELSVTEITWEHAFQLAITVLSIACPCSLGLXXXXXXXXXXXXXXXNGILIKGGEPLENIHKLNVIVFDKTGTITNGSPSVTRFLVLIGNGVREHIDKLLKILAAAESASEHPIGKAIITFSKARISNENLPEVLESSAVSGCGLGCKLNLDPKTEVTKFVKNLINIESPSEETNILGQXXXXXXXXXXXXTYKDVIFPVRQHMAWTSDLCQTVTVIIGNRNWMLRNGILVDDEVDELMSEDENLGRTVILMAIDNELIAMISVADQVKREAALAVYTLKKMNIEVYLMTGDNSKTATAIARQVGIHYVFAEVLPSHKVAKVQQLQNTNRSLTSKRKMKVAMVGDGINDSPALAQSDVGIAIGTGTDVAVEAADVVLIRNSLLDVIAAIQLSKATVKRIRQNFIAATLYNLLGIPIAAGVLMPIGIEMMPWMXXXXXXXXXXXXXXXXXXXXXWKKPSEEKLITPEYINFIQSSGLSESQIIVRRGID 4008
            +++V+GMTC SCV +IE  + K  GV  + VSL + EA + +   +   ED+ + +++MGF+  +KS        KV    +    DI +    + +  LSS          NN   + H  S                 V+ L+        +R++GM C+SCV NIE  +G+  G+ SI+V LE   A    D S   P  ++  I  +   +  +     D   G   +     S        N +    STT++ I  +    C+  IE  +  L GV + SV+L E    + Y+    + +++R  IE +G+                                           LP  +       S  S    +  KC+L+I GMTC+SCV+ +E +L K  GV SVLVAL+A K EI YD   + P +++  +++LGF A V+E+     G + + I GMTC+SCV++IE+ +++  GI   +V+L+TSK  V++     GPRD+I  I ++GF ASL     + H   DH    IKQW+ SF  SL+ GIP M +M+          + +I  N  +++++   + +P    GLS  NLI F+L T VQ  G  YFY+QAY SL+H++ NMDVL+V+ATSI+Y+YS++++V+++A +   SP TFF+T PML VF++LGRWLEH+AK KTSEAL KLMSLQA EAT+ T   +N   +E ++P+ LVQR D++K++PG K PVDGKV+ G +  DESLITGE+MP+ K  GS VI GSIN  G +++KATHVG+D+ LAQIVKLVEEAQ SKAPIQQLADR +G FVP ++I + +TL++W+++GF    ++ +Y       +S TE+    AFQ +ITVL IACPCSLGLATPTAVMVGTGV A NGILIKGG+PLE  HK+  ++FDKTGTIT+G P V R L L+G+     + K+L ++  AE++SEHP+G A+  + K  +  E L    +  AV GCG+GCK            V N+  I + SE    L    +           KD +              QT +V+IGNR W+ RNG+ +  +V + M++ E  G+T IL+AID  L  MI++AD VK+EAALAV+TL+ M ++V L+TGDN KTA AIA QVGI+ VFAEVLPSHKVAKVQ+LQN  +        KVAMVGDG+NDSPALAQ+D+G+AIGTGTDVA+EAADVVLIRN LLDV+A+I LSK TV+RIR N + A +YNL+GIPIAAGV MPIGI + PWM SAAMAASSVSVV  SL LK +KKP  E+    E         L+ SQ+ V  G+D
Sbjct:  146 KLRVEGMTCQSCVSSIEGKVRKLQGVVRVKVSLSNQEAVITYQPYLIQPEDLRDHVNDMGFEAAIKS--------KVAPLSLG-PIDIERLQSTNPKRPLSSA-----NQNFNNSETLGHQGS----------------HVVTLQ--------LRIDGMHCKSCVLNIEENIGQLLGVQSIQVSLENKTAQVKYDPSCTSPVALQRAIEALPPGNFKVS--LPDGAEGSGTDHRSSSSHSPGSPPRNQVQGTCSTTLIAIAGMTCASCVHSIEGMISQLEGVQQISVSLAEGTATVLYNPSVISPEELRAAIEDMGFEASVVSESCSTNPLGNHSAGNSMVQTTDGTPTSVQEVAPHTGRLPANHAPDILAKSPQSTRAVAPQKCFLQIKGMTCASCVSNIERNLQKEAGVLSVLVALMAGKAEIKYDPEVIQPLEIAQFIQDLGFEAAVMEDYAGSDGNIELTITGMTCASCVHNIESKLTRTNGITYASVALATSKALVKFDPEIIGPRDIIKIIEEIGFHASLAQRNPNAHHL-DH-KMEIKQWKKSFLCSLVFGIPVMALMI----------YMLIPSNEPHQSMVLDHNIIP----GLSILNLIFFILCTFVQLLGGWYFYVQAYKSLRHRSANMDVLIVLATSIAYVYSLVILVVAVAEKAERSPVTFFDTPPMLFVFIALGRWLEHLAKSKTSEALAKLMSLQATEATVVTLGEDNLIIREEQVPMELVQRGDIVKVVPGGKFPVDGKVLEGNTMADESLITGEAMPVTKKPGSTVIAGSINAHGSVLIKATHVGNDTTLAQIVKLVEEAQMSKAPIQQLADRFSGYFVPFIIIMSTLTLVVWIVIGFIDFGVVQRYFPNPNKHISQTEVIIRFAFQTSITVLCIACPCSLGLATPTAVMVGTGVAAQNGILIKGGKPLEMAHKIKTVMFDKTGTITHGVPRVMRVL-LLGDVATLPLRKVLAVVGTAEASSEHPLGVAVTKYCKEELGTETLGYCTDFQAVPGCGIGCK------------VSNVEGILAHSERP--LSAPASHLNEAGSLPAEKDAV-------------PQTFSVLIGNREWLRRNGLTISSDVSDAMTDHEMKGQTAILVAIDGVLCGMIAIADAVKQEAALAVHTLQSMGVDVVLITGDNRKTARAIATQVGINKVFAEVLPSHKVAKVQELQNKGK--------KVAMVGDGVNDSPALAQADMGVAIGTGTDVAIEAADVVLIRNDLLDVVASIHLSKRTVRRIRINLVLALIYNLVGIPIAAGVFMPIGIVLQPWMGSAAMAASSVSVVLSSLQLKCYKKPDLERY---EAQAHGHMKPLTASQVSVHIGMD 1407          

Query:  568 VRVNGMTCQSCVDNIESTVGKKQGIISIKVFLEKSEAHA-LVDASLAGPDVEEMINDMGFNSEMILEIFNDSCAGKPNNVSQKYEELKSNTIYPILSTTIVIKALKSIFCIFKIENHMRALPGVDKCSVNLIEEIGMIDYDSGKWNVQKIREEIESLGYLTEL---------------------PKQNWNSTRQS--SAVSLNEESRS--KCYLRITGMTCSSCVNKVESHLLKVEGVKSVLVALLAMKCEIIYDSAYVMPFQLSNRVKEL--GFNAEVIENGNEGIGIVN------------------------VLIRGMTCSSCVNHIENHISKIKGIASINVSLSTSKGKVEYFISECGPRDVIDAINDMGFDASLCDHLESNHAAADH 1587
            VR+ GMTCQSCV +IE  +   +GIIS+KV LE+  A    V + +    V   I DMGF +     I     A  P+      E +            + ++ +    C+  IE  +R L GV +  V+L  +  +I Y       + +R+ +  +G+   +                     PK+  +S  Q+  ++ +L  +        LRI GM C SCV  +E ++ ++ GV+S+ V+L     ++ YD +   P  L   ++ L  G     + +G EG G  +                        + I GMTC+SCV+ IE  IS+++G+  I+VSL+     V Y  S   P ++  AI DMGF+AS+     S +   +H
Sbjct:   62 VRILGMTCQSCVKSIEDRISNLKGIISMKVSLEQGSATVKYVPSVVCLQQVCHQIGDMGFEAS----IAEGKAASWPSRSLPAQEAV----------VKLRVEGMTCQSCVSSIEGKVRKLQGVVRVKVSLSNQEAVITYQPYLIQPEDLRDHVNDMGFEAAIKSKVAPLSLGPIDIERLQSTNPKRPLSSANQNFNNSETLGHQGSHVVTLQLRIDGMHCKSCVLNIEENIGQLLGVQSIQVSLENKTAQVKYDPSCTSPVALQRAIEALPPGNFKVSLPDGAEGSGTDHRSSSSHSPGSPPRNQVQGTCSTTLIAIAGMTCASCVHSIEGMISQLEGVQQISVSLAEGTATVLYNPSVISPEELRAAIEDMGFEASVVSESCSTNPLGNH 439          

Query:  562 VIVRVNGMTCQSCVDNIESTVGKKQGIISIKVFLEKSEAHALVDASLAGP-DVEEMINDMGFNSEMI------------LEIFNDSCAGKP-NNVSQKY--EELKSNTIYPILSTTIVIKALKSIFCIFKIENHMRALPGVDKCSVNLIEEIGMIDYDSGKWNVQKIREEIESLGYLTELPKQNWNSTRQSSAVSLNEESR-------------------SKCYLRITGMTCSSCVNKVESHLLKVEGVKSVLVALLAMKCEIIYDSAYVMPFQLSNRVKELGFNAEVIEN-------GNEGIGIVNVLIR------------------------------------------------GMTCSSCVNHIENHISKIKGIASINVSLSTSKGKVEYFISECGPRDVIDAINDMGFDASLCDHLESNHAAAD 1584
            V +RV GMTCQSCV +IE  V K QG++ +KV L   EA       L  P D+ + +NDMGF + +             +E    +   +P ++ +Q +   E   +    +++  + I  +    C+  IE ++  L GV    V+L  +   + YD    +   ++  IE+      LP  N+  +    A     + R                   S   + I GMTC+SCV+ +E  + ++EGV+ + V+L      ++Y+ + + P +L   ++++GF A V+         GN   G  N +++                                                GMTC+SCV++IE ++ K  G+ S+ V+L   K +++Y      P ++   I D+GF+A++ +    ++A +D
Sbjct:  145 VKLRVEGMTCQSCVSSIEGKVRKLQGVVRVKVSLSNQEAVITYQPYLIQPEDLRDHVNDMGFEAAIKSKVAPLSLGPIDIERLQSTNPKRPLSSANQNFNNSETLGHQGSHVVTLQLRIDGMHCKSCVLNIEENIGQLLGVQSIQVSLENKTAQVKYDPSCTSPVALQRAIEA------LPPGNFKVSLPDGAEGSGTDHRSSSSHSPGSPPRNQVQGTCSTTLIAIAGMTCASCVHSIEGMISQLEGVQQISVSLAEGTATVLYNPSVISPEELRAAIEDMGFEASVVSESCSTNPLGNHSAG--NSMVQTTDGTPTSVQEVAPHTGRLPANHAPDILAKSPQSTRAVAPQKCFLQIKGMTCASCVSNIERNLQKEAGVLSVLVALMAGKAEIKYDPEVIQPLEIAQFIQDLGFEAAVME----DYAGSD 563          

Query:  574 VNGMTCQSCVDNIESTVGKKQGIISIKVFLEKSEAHALVDASLAGPDVEEMINDMGFNSEMILEIFNDSCAGKPNNVSQKYEELKSNTI-YPILSTTIV-IKALKSIFCIFKIENHMRALPGVDKCSVNLIEEIGMIDYDSGKWNVQKIREEIESLGY-----------------LTELP---KQNWNSTRQSSAVSLNEESR--SKCYLRITGMTCSSCVNKVESHLLKVEGVKSVLVALLAMKCEIIYDSAYVMPFQLSNRVKELGFNAEVIENGNEGIGIVNVLIRGMTCSSCVNHIENHISKIKGIASINVSLSTSKGKVEYFISECGPRDVIDAINDMGFDASLCDHLESNHAAADHINQMIKQWRSSFFFSLICGIPXXXXXXXXXXXXXXXXHTIIHENGSNRTIMKSTVPM-----VCSGLSADNLILFVLATPVQFYGARYFYIQAYLSLKHKTTNMDVLVVMATXXXXXXXXXXXXXXMAFRRNTSPKTFFETSPMLIVFLSLGRWLEHIAKGKTSEALTKLMSLQAVEATLYTPEN-----KERKIPINLVQRNDLIKILPGEKIPVDGKVVTGTSTCDESLITGESMPIEKTHGSDVIGGSINKSGMLIVKATHVGSDSALAQIVKLVEEAQTSKAPIQQLADRIAGMFVPSVLICAIITLIIWVIVGFSKPEI----LPKYVNELSVTEITWEHAFQLAITVLSIACPCSLGLXXXXXXXXXXXXXXXNGILIKGGEPLENIHKLNVIVFDKTGTITNGSPSVTRFLVLI-GNGVREHIDKLLKILAAAESASEHPIGKAIITFSKARISNENLPEVLESSAVSGCGLGCKLNLDPKTEVTKFV-KNLINIESPSEETNILGQXXXXXXXXXXXXTYKDVIFPVRQHMAWTSDLCQTVTVIIGNRNWMLRNGILVDDEVDELMSEDENLGRTVILMAIDNELIAMISVADQVKREAALAVYTLKKMNIEVYLMTGDNSKTATAIARQVGIHYVFAEVLPSHKVAKVQQLQNTNRSLTSKRKMKVAMVGDGINDSPALAQSDVGIAIGTGTDVAVEAADVVLIRNSLLDVIAAIQLSKATVKRIRQNFIAATLYNLLGIPIAAGVLMPIGIEMMPWMXXXXXXXXXXXXXXXXXXXXXWKKPSEEKLITPEYINFIQSSGLSESQIIVRRGID 4008
            ++GM C+SCV NIEST+   Q + SI V LE   A    +AS   P+      +        + I ++  +   +  S   +++  N +  P+   T++ I  +    C+  IE  +   PGV    V+L    G ++YD    + + +R  IE +G+                  +E+P     N   T+  + V   EE +  SKCY+++TGMTC+SCV  +E +L + EG+ S+LVAL+A K E+ Y+ A + P  ++  ++ELGF A VIEN +EG G++ +++RGMTC+SCV+ IE+ ++K +GI   +V+L+T+K  ++Y     GPRD+I  I  +GF+ASL    + + +  DH  + I+QWR SF  SL   IP M +M++ M           ++N S   ++     M     +  GLS  NL+ F+L  PVQF+G  YFYIQAY +LKHKT NMDVL+V+AT+I++ YS+I+++++M  R   +P TFF+T PML VF++LGRWLEHIAKGKTSEAL KL+SLQA EAT+ T ++      E ++ + LVQR D+IK++PG K PVDG+V+ G S  DESLITGE+MP+ K  GS VI GSIN++G L++ ATHVG+D+ L+QIVKLVEEAQTSKAPIQQ AD+++G FVP ++  +I TL++W+++GF   EI     P Y   +S TE     AFQ +ITVL IACPCSLGLATPTAVMVGTGVGA NGILIKGGEPLE  HK+ V+VFDKTGTIT+G+P V +  VL   N +  H  K+L I+  AES SEHP+G AI  + K  +  E L   ++   V GCG+ CK+     T +   + KN  NIE  + +   L Q    N       +   +I   +   A  +   Q   V+IGNR WM+RNG++++++V++ M+E E  GRT +L+A+D+EL  +I++AD VK EA LA++ LK M +EV LMTGDNSKTA +IA QVGI  VFAEVLPSHKVAKV+QLQ   +        +VAMVGDGINDSPALA ++VGIAIGTGTDVA+EAADVVLIRN LLDV+A+I LS+ TVKRIR NF+ A +YNL+GIPIAAGV MPIG+ + PWM SAAMAASSVSVV  SL LKL++KP+ E    P      Q    S S+I V  GID
Sbjct:  283 IDGMHCKSCVSNIESTLSALQYVSSIVVSLENRSAIVKYNASSVTPESLRKAIEAVSPGLYRVSITSEVESTSNSPSSSSLQKIPLNVVSQPLTQETVINIDGMTCNSCVQSIEGVISKKPGVKSIRVSLANSNGTVEYDPLLTSPETLRGAIEDMGFDATLSDTNEPLVVIAQPSSEMPLLTSTNEFYTKGMTPVQDKEEGKNSSKCYIQVTGMTCASCVANIERNLRREEGIYSILVALMAGKAEVRYNPAVIQPPMIAEFIRELGFGATVIENADEGDGVLELVVRGMTCASCVHKIESSLTKHRGILYCSVALATNKAHIKYDPEIIGPRDIIHTIESLGFEASLVKK-DRSASHLDH-KREIRQWRRSFLVSLFFCIPVMGLMIYMMVMDHHFATLHHNQNMSKEEMINLHSSMFLERQILPGLSVMNLLSFLLCVPVQFFGGWYFYIQAYKALKHKTANMDVLIVLATTIAFAYSLIILLVAMYERAKVNPITFFDTPPMLFVFIALGRWLEHIAKGKTSEALAKLISLQATEATIVTLDSDNILLSEEQVDVELVQRGDIIKVVPGGKFPVDGRVIEGHSMVDESLITGEAMPVAKKPGSTVIAGSINQNGSLLICATHVGADTTLSQIVKLVEEAQTSKAPIQQFADKLSGYFVPFIVFVSIATLLVWIVIGFLNFEIVETYFPGYNRSISRTETIIRFAFQASITVLCIACPCSLGLATPTAVMVGTGVGAQNGILIKGGEPLEMAHKVKVVVFDKTGTITHGTPVVNQVKVLTESNRISHH--KILAIVGTAESNSEHPLGTAITKYCKQELDTETLGTCIDFQVVPGCGISCKV-----TNIEGLLHKNNWNIEDNNIKNASLVQIDASNEQSSTSSS---MIIDAQISNALNA---QQYKVLIGNREWMIRNGLVINNDVNDFMTEHERKGRTAVLVAVDDELCGLIAIADTVKPEAELAIHILKSMGLEVVLMTGDNSKTARSIASQVGITKVFAEVLPSHKVAKVKQLQEEGK--------RVAMVGDGINDSPALAMANVGIAIGTGTDVAIEAADVVLIRNDLLDVVASIDLSRKTVKRIRINFVFALIYNLVGIPIAAGVFMPIGLVLQPWMGSAAMAASSVSVVLSSLFLKLYRKPTYESYELPARSQIGQK---SPSEISVHVGID 1441          

Query:   91 MKLGSARMKVDGMTCMSCVRNIEENLMKFTGVCGIMVSLLHAEATVIFDADIATVEDISNKIDEMGFDVTVKSSE----VSNVKDKVVRSRIKFESDINKSVEKSIETSLSSKLLLVRFCQENNYADIWHYSSIRS---TEILSVIQQSEI----------YGVL----------VLEQCPTIRVIVRVNGMTCQSCVDNIESTVGKKQGIISIKVFLEKSEAHALVDASLAGPDVEEM---INDMGFNSEM--------ILEIFNDSCAGKPNNVSQKYEELKSNTIYPILSTTIVIKALKSIFCIFKIENHMRALPGVDKCSVNLIEEIGMIDYDSGKWNVQKIREEIESLG---YLTELPKQ-----NWNSTRQSSAVSLNEESR---SKCYLRITGMTCSSCVNKVESHLLKVEGVKSVLVALLAMKCEIIYDSAYVMPFQLSNRVKELGFNAEVIENGNEGIGIVN------------------------------------VLIRGMTCSSCVNHIENHISKIKGIASINVSLSTSKGKVEYFISECGPRDVIDAINDMGFDASLCDHLE 1563
            M + S  + V+GMTC SCV  IE+ + K  GV  I VSL    AT+I+D  + T + +   ID+MGFD  + + +    +++     V + +    D            + S LL     +     DI  Y   R+   T I S++  ++I           G L           + Q   + + ++V GMTC SC   IE  +GK QG+  IKV L+  EA  +    L    VEEM   I  MGF + +        +  I  +     P   S+  ++ +S +     + T +I  +    C+  IE+ + AL  V    V+L     ++ Y++     + +R+ IE++    Y   +  +     N  S+     + LN  S+    +  + I GMTC+SCV  +E  + K  GVKS+ V+L      + YD     P  L   ++++GF+A  + + NE + ++                                     + + GMTC+SCV +IE ++ + +GI SI V+L   K +V Y  +   P  + + I ++GF A++ ++ +
Sbjct:    5 MGVNSVTISVEGMTCNSCVWTIEQQIGKVNGVHHIKVSLEEKNATIIYDPKLQTPKTLQEAIDDMGFDAVIHNPDPLPVLTDTLFLTVTASLTLPWD-----------HIQSTLL-----KTKGVTDIKIYPQKRTVAVTIIPSIVNANQIKELVPELSLDTGTLEKKSGACEDHSMAQAGEVVLKMKVEGMTCHSCTSTIEGKIGKLQGVQRIKVSLDNQEATIVYQPHLI--SVEEMKKQIEAMGFPAFVKKQPKYLKLGAIDVERLKNTPVKSSEGSQQ-RSPSYTNDSTATFIIDGMHCKSCVSNIESTLSALQYVSSIVVSLENRSAIVKYNASSVTPESLRKAIEAVSPGLYRVSITSEVESTSNSPSSSSLQKIPLNVVSQPLTQETVINIDGMTCNSCVQSIEGVISKKPGVKSIRVSLANSNGTVEYDPLLTSPETLRGAIEDMGFDA-TLSDTNEPLVVIAQPSSEMPLLTSTNEFYTKGMTPVQDKEEGKNSSKCYIQVTGMTCASCVANIERNLRREEGIYSILVALMAGKAEVRYNPAVIQPPMIAEFIRELGFGATVIENAD 560          

Query:  109 RMKVDGMTCMSCVRNIEENLMKFTGVCGIMVSLLHAEATVIFDADIATVEDISNKIDEMGFDVTVKSS---------EVSNVKDKVVRS----RIKFESDINKSVE---------KSIETSLSSKLLLVRFCQ------ENNYADI-WHYSSIRSTEILSVIQ--QSEIYGVLV---------------LEQCP--------TIRVIVRVNGMTCQSCVDNIESTVGKKQGIISIKVFLEKSEAHALVDASLAGPD-VEEMINDMGFN-----------------SEMILEIFNDSCAGKPNNVSQKYEELKSNTIYPILSTTIVIKALKSIFCIFKIENHMRALPGVDKCSVNLIEEIGMIDYDSGKWNVQKIREEIESLGYLTELPKQNWNSTRQSSAVSLNEESRSKCYLRITGMTCSSCVNKVESHLLKVEGVKSVLVALLAMKCEIIYDSAYVMPFQLSNRVKELGFNAEVIE 1326
            +MKV+GMTC SC   IE  + K  GV  I VSL + EAT+++   + +VE++  +I+ MGF   VK           +V  +K+  V+S    + +  S  N S           KS  +++ S L  +++        EN  A + ++ SS+    +   I+     +Y V +               L++ P        T   ++ ++GMTC SCV +IE  + KK G+ SI+V L  S      D  L  P+ +   I DMGF+                 SEM L    +    K     Q  EE K+++        I +  +    C+  IE ++R   G+    V L+     + Y+        I E I  LG+              ++ +   +E      L + GMTC+SCV+K+ES L K  G+    VAL   K  I YD   + P  + + ++ LGF A +++
Sbjct:  174 KMKVEGMTCHSCTSTIEGKIGKLQGVQRIKVSLDNQEATIVYQPHLISVEEMKKQIEAMGFPAFVKKQPKYLKLGAIDVERLKNTPVKSSEGSQQRSPSYTNDSTATFIIDGMHCKSCVSNIESTLSALQYVSSIVVSLENRSAIVKYNASSVTPESLRKAIEAVSPGLYRVSITSEVESTSNSPSSSSLQKIPLNVVSQPLTQETVINIDGMTCNSCVQSIEGVISKKPGVKSIRVSLANSNGTVEYDPLLTSPETLRGAIEDMGFDATLSDTNEPLVVIAQPSSEMPLLTSTNEFYTKGMTPVQDKEEGKNSS-----KCYIQVTGMTCASCVANIERNLRREEGIYSILVALMAGKAEVRYNPAVIQPPMIAEFIRELGF-------------GATVIENADEGDGVLELVVRGMTCASCVHKIESSLTKHRGILYCSVALATNKAHIKYDPEIIGPRDIIHTIESLGFEASLVK 633          

Query:  109 RMKVDGMTCMSCVRNIEENLMKFTGVCGIMVSLLHAEATVIFDADIATVEDISNKIDEMGFDVTVKSSEVSNVKDKVVR-SRIKFESDINKSVEKSIETSLSSKLLLVRFCQENNYADIWHYSSIRSTEILSVIQQSEIYGVLVLEQCPTIRVIVRVNGMTCQSCVDNIESTVGKKQGIISIKVFLEKSEAHALVDASLAGPDVEEMINDMGFNSEMILEIFNDSCAGKPNNVSQKYEELKSNTI-YPILSTTIV-IKALKSIFCIFKIENHMRALPGVDKCSVNLIEEIGMIDYDSGKWNVQKIREEIESLGYLTELPKQN-------WNSTRQSSAVSLNEES------RSKCYLRITGMTCSSCVNKVESHLLKVEGVKSVLVALLAMKCEIIYDSAYVMPFQLSNRVKELGFNAEVIENGNEGIGIVNVLIRGMTCSSCVNHIENHISKIKGIASINVSLSTSKGKVEYFISECGPRDVIDAINDMGFDASLCDHLESNHAAADHINQMIKQWRSSFFFSLICGIPXXXXXXXXXXXXXXXXHTIIHENGS--NRTIMKSTVPM-----VCSGLSADNLILFVLATPVQFYGARYFYIQAYLSLKHKTTNMDVLVVMATXXXXXXXXXXXXXXMAFRRNTSPKTFFETSPMLIVFLSLGRWLEHIAKGKTSEALTKLMSLQAVEATLYTPEN-----KERKIPINLVQRNDLIKILPGEKIPVDGKVVTGTSTCDESLITGESMPIEKTHGSDVIGGSINKSGMLIVKATHVGSDSALAQIVKLVEEAQTSKAPIQQLADRIAGMFVPSVLICAIITLIIWVIVGFSKPEI----LPKYVNELSVTEITWEHAFQLAITVLSIACPCSLGLXXXXXXXXXXXXXXXNGILIKGGEPLENIHKLNVIVFDKTGTITNGSPSVTRFLVLI-GNGVREHIDKLLKILAAAESASEHPIGKAIITFSKARISNENLPEVLESSAVSGCGLGCKL----------NLDPKTEVTKFVKNLINIESPSEETNILGQXXXXXXXXXXXXTYKDVIFPVRQHMAWTSDLCQTVTVIIGNRNWMLRNGILVDDEVDELMSEDENLGRTVILMAIDNELIAMISVADQVKREAALAVYTLKKMNIEVYLMTGDNSKTATAIARQVGIHYVFAEVLPSHKVAKVQQLQNTNRSLTSKRKMKVAMVGDGINDSPALAQSDVGIAIGTGTDVAVEAADVVLIRNSLLDVIAAIQLSKATVKRIRQNFIAATLYNLLGIPIAAGVLMPIGIEMMPWMXXXXXXXXXXXXXXXXXXXXXWKKPSEEKLITPEYINFIQSSGLSESQIIVRRGID 4008
            ++KV+GMTC SC    E  + K  GV  I VSL + EAT+++   + +VE+I  +I+ MGF   VK       + K ++   I  E   N  V KS+E S           Q  +Y                    S+     ++E            GM C+SCV NIES +   Q + SI V LE   A    +AS   P++     +     +  + I N+  +   +  S   +++  N +  P+   T++ I  +    C+  IE  +   PGV    V+L    G ++YD      + +RE I  +G+   LP  +         S       S N++        SKCY++++GMTC+SCV  +E +L + EG+ SVLVAL+A K E+ Y+ A + P  ++  ++ELGF A V+EN +EG GI+ +++RGMTC+SCV+ IE+ ++K KGI   +V+L+T+K  ++Y     GPRD+I  I  +GF+ASL    + + +  DH  + IKQWRSSF  SL    P M +MM+ M          IH N S  N  ++K+   M     +  GLS  NL+  +L  PVQF+G  YFYIQAY +LKHKT NMDVL+V+AT+I++ YS+I+++++M  R   +P T F+T PML VF++LGRWLEHIAKGKTSEAL KL+SLQA EAT+ T ++      E ++ + LVQR D+IK++PG K PVDG+V+ G S  DESLITGE+MP+ K  GS VI GSIN++G L++ ATHVG+D+ L+QIVKLVEEAQTSKAPIQQ AD++ G FVP +++ +I TL++W+I+GF    I     P Y   +S TE     AFQ +ITVL IACPCSLGLATPTAVMVGTGVGA NGILIKGGEPLE  HK+ V+VFDKTGTIT+G+P V +  VL+  N +     K+L I+  AES SEHP+G A+  + K  +  E L    +   V GCG+ CK+          NL  +   TK   +L+ I++ +E+++     +      +   T                   Q   V+IGNR WM+RNG+++ ++VD+ M +    GR  +L+ ID+EL  +I++AD VK EA LAV+ LK M +EV LMTGDNSKTA +IA QVGI  VFAEVLPSHKVAKV+QLQ   +        +VAMVGDGINDSPALA ++VGIAIGTGTDV +EAADVV IRN LLDV+A+I LS+ TVKRIR NF+   +YNL+GIPIAAGV +PIG+   PWM SAAMAASSVSVV  SL LKL++KP+ +     E      +   S S+I V  GID
Sbjct:  174 KIKVEGMTCHSCTSTTEGKIGKLQGVQRIKVSLDNQEATIVYQPHLISVEEIKKQIEAMGFPAFVKK------QPKYLKLGAIDVERLKNTPV-KSLEGSQ----------QRPSYP-------------------SDSTATFIIE------------GMHCKSCVSNIESALPTLQYVSSIAVSLENRSAIVKYNASSVTPEMLIKAIEAVSPGQYRVSIANEVESTSSSPSSSSLQKMPLNVVSQPLTQETVINISGMTCNSCVQSIEGVVSKKPGVKSIHVSLANSFGTVEYDPLLTAPETLREVIVDMGFDAVLPDMSEPLVVIAQPSLETPLLPSTNDQDNMMTAVHSKCYIQVSGMTCASCVANIERNLRREEGIYSVLVALMAGKAEVRYNPAVIQPPVIAEFIRELGFGATVMENADEGDGILKLVVRGMTCASCVHKIESTLTKHKGIFYCSVALATNKAHIKYDPEIIGPRDIIHTIGSLGFEASLVKK-DRSASHLDH-KREIKQWRSSFLVSLFFCTPVMGLMMYMMAMEHH--FATIHHNQSMSNEEMIKNHSSMFLERQILPGLSIMNLLSLLLCLPVQFFGGWYFYIQAYKALKHKTANMDVLIVLATTIAFAYSLIILLVAMYERAKVNPITSFDTPPMLFVFIALGRWLEHIAKGKTSEALAKLISLQATEATIVTLDSDNILLSEEQVDVELVQRGDIIKVVPGGKFPVDGRVIEGHSMVDESLITGEAMPVAKKPGSTVIAGSINQNGSLLICATHVGADTTLSQIVKLVEEAQTSKAPIQQFADKLGGYFVPFIVLVSIATLLVWIIIGFQNFTIVETYFPGYSRSISRTETIIRFAFQASITVLCIACPCSLGLATPTAVMVGTGVGAQNGILIKGGEPLEMAHKVKVVVFDKTGTITHGTPVVNQVKVLVESNKIPR--SKILAIVGTAESNSEHPLGAAVTKYCKQELDTETLGTCTDFQVVPGCGISCKVTNIEGLLHKSNLKIEENNTKNA-SLVQIDAINEQSSTSSSMIIDAPLSNAVDT-------------------QQYKVLIGNREWMIRNGLVISNDVDDSMIDHGRKGRPAVLVTIDDELCGLIAIADTVKPEAELAVHILKSMGLEVVLMTGDNSKTARSIASQVGITKVFAEVLPSHKVAKVKQLQEEGK--------RVAMVGDGINDSPALAMANVGIAIGTGTDVTIEAADVVFIRNDLLDVVASIDLSRKTVKRIRINFLFPLIYNLVGIPIAAGVFLPIGLVFQPWMGSAAMAASSVSVVLSSLFLKLYRKPTYDNY---ELRTRSHTGQRSPSEISVHVGID 1431          

Query:   91 MKLGSARMKVDGMTCMSCVRNIEENLMKFTGVCGIMVSLLHAEATVIFDADIATVEDISNKIDEMGFDVTVKSSE----VSNVKDKVVRSRIKFESDINKSVEKSIETSLSSKLLLVRFCQENNYADIWHYSSIRSTEILSVIQQSEI-YGVL----------VLEQCPTIRVIVRVNGMTCQSCVDNIESTVGKKQGIISIKVFLEKSEAHALVDASLAG-PDVEEMINDMGFNS-----EMILEIFNDSCAGKPNNVSQKYEELKSNTIYPILST-TIVIKALKSIFCIFKIENHMRALPGVDKCSVNLIEEIGMIDYDSGKWNVQKIREEIESLG---YLTELPKQNWNSTRQSSAVSL--------NEESRSKCYLRITGMTCSSCVNKVESHLLKVEGVKSVLVALLAMKCEIIYDSAYVMPFQLSNRVKELGFNAEVIENGNEGIGIVN---------------------------VLIRGMTCSSCVNHIENHISKIKGIASINVSLSTSKGKVEYFISECGPRDVIDAINDMGFDASLCDHLE 1563
            M + S  + V+GMTC+SCVR IE+ + K  G+  I VSL    AT+I+D  + T + +   ID+MGFD  + ++     +++     V + +    D  +S     +     K+    F Q+   A     S + + +I  ++ +  +  G L           + Q   + + ++V GMTC SC    E  +GK QG+  IKV L+  EA  +    L    ++++ I  MGF +        L++         N   +  E  +    YP  ST T +I+ +    C+  IE+ +  L  V   +V+L     ++ Y++     + + + IE++    Y   +  +  +++   S+ SL        ++    +  + I+GMTC+SCV  +E  + K  GVKS+ V+L      + YD     P  L   + ++GF+A V+ + +E + ++                            + + GMTC+SCV +IE ++ + +GI S+ V+L   K +V Y  +   P  + + I ++GF A++ ++ +
Sbjct:    5 MDVNSVTISVEGMTCISCVRTIEQKIGKENGIHHIKVSLEEKSATIIYDPKLQTPKTLQEAIDDMGFDALLHNANPLPVLTDTLFLTVTASLTLPWDHIQSTLLKTKGVTDIKI----FPQKRTLAVTIIPSIVNANQIKELVPELSLETGTLEKRSGACEDHSMAQAGEVVLKIKVEGMTCHSCTSTTEGKIGKLQGVQRIKVSLDNQEATIVYQPHLISVEEIKKQIEAMGFPAFVKKQPKYLKLGAIDVERLKNTPVKSLEGSQQRPSYPSDSTATFIIEGMHCKSCVSNIESALPTLQYVSSIAVSLENRSAIVKYNASSVTPEMLIKAIEAVSPGQYRVSIANEVESTSSSPSSSSLQKMPLNVVSQPLTQETVINISGMTCNSCVQSIEGVVSKKPGVKSIHVSLANSFGTVEYDPLLTAPETLREVIVDMGFDA-VLPDMSEPLVVIAQPSLETPLLPSTNDQDNMMTAVHSKCYIQVSGMTCASCVANIERNLRREEGIYSVLVALMAGKAEVRYNPAVIQPPVIAEFIRELGFGATVMENAD 550          

Query:  574 VNGMTCQSCVDNIESTVGKKQGIISIKVFLEKSEAHALVDASLAGPDVEEMINDMGFNSEMILEIFNDSCAGKPNNVSQKYEELKSNTIYPILSTTIVIK--ALKSIFCIFKIENHMRALPGVDKCSVNLIEEIGMIDYDSGKWNVQKIREEIESLGYLTELP---KQNWNSTRQSSA-----VSLNEES------RSKCYLRITGMTCSSCVNKVESHLLKVEGVKSVLVALLAMKCEIIYDSAYVMPFQLSNRVKELGFNAEVIENGNEGIGIVNVLIRGMTCSSCVNHIENHISKIKGIASINVSLSTSKGKVEYFISECGPRDVIDAINDMGFDASLCDHLES-NHAAADHINQMIKQWRSSFFFSLICGIPXXXXXXXXXXXXXXXXHTIIHENGSNRTIMKSTVPM-----VCSGLSADNLILFVLATPVQFYGARYFYIQAYLSLKHKTTNMDVLVVMATXXXXXXXXXXXXXXMAFRRNTSPKTFFETSPMLIVFLSLGRWLEHIAKGKTSEALTKLMSLQAVEATLYT--PEN---KERKIPINLVQRNDLIKILPGEKIPVDGKVVTGTSTCDESLITGESMPIEKTHGSDVIGGSINKSGMLIVKATHVGSDSALAQIVKLVEEAQTSKAPIQQLADRIAGMFVPSVLICAIITLIIWVIVGFSKPEI----LPKYVNELSVTEITWEHAFQLAITVLSIACPCSLGLXXXXXXXXXXXXXXXNGILIKGGEPLENIHKLNVIVFDKTGTITNGSPSVTRFLVLI-GNGVREHIDKLLKILAAAESASEHPIGKAIITFSKARISNENLPEVLESSAVSGCGLGCKLNLDPKTEVTKFVKNLINIESPSEETNILGQXXXXXXXXXXXXTYKDVIFPVRQHMAWTSDLCQTVTVIIGNRNWMLRNGILVDDEVDELMSEDENLGRTVILMAIDNELIAMISVADQVKREAALAVYTLKKMNIEVYLMTGDNSKTATAIARQVGIHYVFAEVLPSHKVAKVQQLQNTNRSLTSKRKMKVAMVGDGINDSPALAQSDVGIAIGTGTDVAVEAADVVLIRNSLLDVIAAIQLSKATVKRIRQNFIAATLYNLLGIPIAAGVLMPIGIEMMPWMXXXXXXXXXXXXXXXXXXXXXWKKPSEEKLITPEYINFIQSSGLSESQIIVRRGID 4008
            ++GM C+SCV NIES +   Q + SI V LE   A    +ASL  P++     +     +  + I ++  +   +  S   +++  N +   L+  +VI    +    C+  IE  +   PGV    V+L    G I+YD    + + +RE IE +G+   LP   K+      Q S       S  E        ++KCY++++GMTC+SCV  +E +L + EG+ SVLVAL+A K E+ Y+ A + P  ++  ++ELGF A V+EN  EG GI+ +++RGMTC+SCV+ IE+ ++K KGI   +V+L+T+K  ++Y     GPRD+I  I ++GF+ASL     S NH   DH  + IKQWR SF  SL   IP M +M++ M     +     ++N SN  ++     M     +  GLS  NL+  +L  PVQF G  YFYIQAY +L+HKT NMDVL+V+AT+I++ YS+++++++M  R   +P TFF+T PML VF++LGRWLEHIAKGKTSEAL KL+SLQA EAT+ T   EN    E ++ + LVQR D+IK++PG K PVDG+V+ G S  DESLITGE+MP+ K  GS VI GSIN++G L+++ATHVG+D+ L+QIVKLVEEAQTSKAPIQQ AD+++G FVP +++ +I+TL++W+I+GF   EI     P Y   +S TE     AFQ +ITVL IACPCSLGLATPTAVMVGTGVGA NGILIKGGEPLE  HK+ V+VFDKTGTIT+G+P V +  VL+  N +    +K+L I+  AES SEHP+G A+  + K  +  E L    +   V GCG+ CK+           ++ L++  +   E N +     + I+     +       +  H++   +  Q   V+IGNR WM+RNG+++ ++VDE M E E  GRT +L+ ID+EL  +I++AD VK EA LAV+ LK M +EV LMTGDNSKTA +IA QVGI  VFAEVLPSHKVAKV+QLQ   +        +VAMVGDGINDSPALA + VGIAIGTGTDVA+EAADVVLIRN LLDV+A+I LS+ TVKRIR NF+ A +YNL+GIPIAAGV +PIG+ + PWM SAAMAASSVSVV  SL LKL++KP+ +     E      +   S S+I V  GID
Sbjct:  283 IDGMHCKSCVSNIESALSTLQYVSSIVVSLENRSAIVKYNASLVTPEILRKAIEAVSPGQYRVSISSEVESPTSSPSSSSLQKMPLNLVSQPLTQEVVININGMTCNSCVQSIEGVISKKPGVKSIHVSLTNSTGTIEYDPLLTSPEPLREAIEDMGFDAVLPADMKEPLVVIAQPSLETPLLPSTTEPENVMTPVQNKCYIQVSGMTCASCVANIERNLRREEGIYSVLVALMAGKAEVRYNPAVIQPRVIAELIRELGFGAVVMENAGEGNGILELVVRGMTCASCVHKIESTLTKHKGIFYCSVALATNKAHIKYDPEIIGPRDIIHTIGNLGFEASLVKKDRSANHL--DH-KREIKQWRGSFLVSLFFCIPVMGLMIYMMVMDHHLATLNHNQNMSNEEMINMHSSMFLERQILPGLSIMNLLSLLLCLPVQFCGGWYFYIQAYKALRHKTANMDVLIVLATTIAFAYSLVILLVAMYERAKVNPITFFDTPPMLFVFIALGRWLEHIAKGKTSEALAKLISLQATEATIVTLNSENLLLSEEQVDVELVQRGDIIKVVPGGKFPVDGRVIEGHSMVDESLITGEAMPVAKKPGSTVIAGSINQNGSLLIRATHVGADTTLSQIVKLVEEAQTSKAPIQQFADKLSGYFVPFIVLVSIVTLLVWIIIGFQNFEIVEAYFPGYNRSISRTETIIRFAFQASITVLCIACPCSLGLATPTAVMVGTGVGAQNGILIKGGEPLEMAHKVKVVVFDKTGTITHGTPVVNQVKVLVESNKISR--NKILAIVGTAESNSEHPLGAAVTKYCKQELDTETLGTCTDFQVVPGCGISCKVT---------NIEGLLHKSNLKIEENNIKNASLVQIDAINEQSSPSSSMIIDAHLSNAVN-TQQYKVLIGNREWMIRNGLVISNDVDESMIEHERRGRTAVLVTIDDELCGLIAIADTVKPEAELAVHILKSMGLEVVLMTGDNSKTARSIASQVGITKVFAEVLPSHKVAKVKQLQEEGK--------RVAMVGDGINDSPALAMASVGIAIGTGTDVAIEAADVVLIRNDLLDVVASIDLSRKTVKRIRINFVFALIYNLIGIPIAAGVFLPIGLVLQPWMGSAAMAASSVSVVLSSLFLKLYRKPTYDNY---ELRPRSHTGQRSPSEISVHVGID 1433          

Query:   91 MKLGSARMKVDGMTCMSCVRNIEENLMKFTGVCGIMVSLLHAEATVIFDADIATVEDISNKIDEMGFDVTVKSSE----VSNVKDKVVRSRIKFESDINKSVEKSIETSLSSKLLL-VRFCQENNYADIWHYSSIRST-EILSVIQ--------QSEIYGVLVLEQCPT---IRVIVRVNGMTCQSCVDNIESTVGKKQGIISIKVFLEKSEAHALVDASL-AGPDVEEMINDMGFNSEM--------ILEIFNDSCAGKPNNVSQKYEELKSNTIYPILST-TIVIKALKSIFCIFKIENHMRALPGVDKCSVNLIEEIGMIDYDSGKWNVQKIREEIESLG---YLTELPKQNWNSTRQSSAVSL--------NEESRSKCYLRITGMTCSSCVNKVESHLLKVEGVKSVLVALLAMKCEIIYDSAYVMPFQLSNRVKELGFNAEVIENGNEGIGIV-----------------NVL----------IRGMTCSSCVNHIENHISKIKGIASINVSLSTSKGKVEYFISECGPRDVIDAINDMGFDA 1542
            M   S  + V+GMTC+SCVR IE+ + K  GV  I VSL    ATVI++  + T + +   ID+MGFD  + ++     ++N     V + +    D  +S      T L +K +  V+   +   A +    S+ S  +I+ ++         Q +  G       P    + + +RV GMTC SC   IE  VGK QG+  IKV L+  EA  +    L    ++++ I  +GF + +        +  I  +     P   S+  ++   +  YP  S  T  I  +    C+  IE+ +  L  V    V+L     ++ Y++     + +R+ IE++    Y   +  +  + T   S+ SL        ++    +  + I GMTC+SCV  +E  + K  GVKS+ V+L      I YD     P  L   ++++GF+A +  +  E + ++                 NV+          + GMTC+SCV +IE ++ + +GI S+ V+L   K +V Y  +   PR + + I ++GF A
Sbjct:    5 MDANSITITVEGMTCISCVRTIEQQIGKVNGVHHIKVSLEEKSATVIYNPKLQTPKTLQEAIDDMGFDALLHNANPLPVLTNTVFLTVTAPLALPWDHIQS------TLLKTKGVTGVKISPQQRSAVVTIIPSVVSANQIVELVPDLSLDMGTQEKKSGTSEEHSTPQAGEVLLKMRVEGMTCHSCTSTIEGKVGKLQGVQRIKVSLDNQEATIVYQPHLITAEEIKKQIEAVGFPAFIKKQPKYLKLGAIDVERLKSTPVKSSEGSQQ--KSPAYPSDSAITFTIDGMHCKSCVSNIESALSTLQYVSSIVVSLENRSAIVKYNASLVTPEILRKAIEAVSPGQYRVSISSEVESPTSSPSSSSLQKMPLNLVSQPLTQEVVININGMTCNSCVQSIEGVISKKPGVKSIHVSLTNSTGTIEYDPLLTSPEPLREAIEDMGFDAVLPADMKEPLVVIAQPSLETPLLPSTTEPENVMTPVQNKCYIQVSGMTCASCVANIERNLRREEGIYSVLVALMAGKAEVRYNPAVIQPRVIAELIRELGFGA 545          

Query:  109 RMKVDGMTCMSCVRNIEENLMKFTGVCGIMVSLLHAEATVIFDADIATVEDISNKIDEMGF----------------DV------TVKSSEVSNVKDKVVRSRIKFESDIN----KSVEKSIETSLSSKLLL--VRFCQENNYADIWHYSSIRSTEILS------------VIQQSEI------YGVLVLEQCP--------TIRVIVRVNGMTCQSCVDNIESTVGKKQGIISIKVFLEKSEAHALVDASLAGPD-VEEMINDMGFNS-------EMILEIFNDS-------CAGKPNNVSQKYEELKSNTIYPILSTTIVIKALKSIFCIFKIENHMRALPGVDKCSVNLIEEIGMIDYDSGKWNVQKIREEIESLGYLTELPKQNWNSTRQSSAVSLNE--ESRSKCYLRITGMTCSSCVNKVESHLLKVEGVKSVLVALLAMKCEIIYDSAYVMPFQLSNRVKELGFNAEVIE 1326
            +M+V+GMTC SC   IE  + K  GV  I VSL + EAT+++   + T E+I  +I+ +GF                DV       VKSSE S  K     S       I+    KS   +IE++LS+   +  +    EN  A + + +S+ + EIL             V   SE+           L++ P        T  V++ +NGMTC SCV +IE  + KK G+ SI V L  S      D  L  P+ + E I DMGF++       E ++ I   S          +P NV    +    N  Y      I +  +    C+  IE ++R   G+    V L+     + Y+      + I E I  LG+                AV +    E      L + GMTC+SCV+K+ES L K +G+    VAL   K  I YD   + P  + + +  LGF A +++
Sbjct:  174 KMRVEGMTCHSCTSTIEGKVGKLQGVQRIKVSLDNQEATIVYQPHLITAEEIKKQIEAVGFPAFIKKQPKYLKLGAIDVERLKSTPVKSSEGSQQKSPAYPSDSAITFTIDGMHCKSCVSNIESALSTLQYVSSIVVSLENRSAIVKYNASLVTPEILRKAIEAVSPGQYRVSISSEVESPTSSPSSSSLQKMPLNLVSQPLTQEVVININGMTCNSCVQSIEGVISKKPGVKSIHVSLTNSTGTIEYDPLLTSPEPLREAIEDMGFDAVLPADMKEPLVVIAQPSLETPLLPSTTEPENVMTPVQ----NKCY------IQVSGMTCASCVANIERNLRREEGIYSVLVALMAGKAEVRYNPAVIQPRVIAELIRELGF---------------GAVVMENAGEGNGILELVVRGMTCASCVHKIESTLTKHKGIFYCSVALATNKAHIKYDPEIIGPRDIIHTIGNLGFEASLVK 625          

Query: 1351 VNVLIRGMTCSSCVNHIENHISKIKGIASINVSLSTSKGKVEYFISECGPRDVIDAINDMGFDASL 1548
            + + + GMTC SCV  IE  I K+ G+  I VSL      V Y      P+ + +AI+DMGFDA L
Sbjct:   10 ITITVEGMTCISCVRTIEQQIGKVNGVHHIKVSLEEKSATVIYNPKLQTPKTLQEAIDDMGFDALL 75          

Query:  109 RMKVDGMTCMSCVRNIEENLMKFTGVCGIMVSLLHAEATVIFDADIATVEDISNKIDEMGFDVTVKSSEVSNVKDKV-----VRS-------RIKFESDINKSVEKSIETSLSS--KLLLVRFCQENNYADIWHYSSIRSTEILS-----------VIQQSEIYGVLVLEQCPT--------IRVIVRVNGMTCQSCVDNIESTVGKKQGIISIKVFLEKSEAHALVDASLAGP-DVEEMINDMGFNSEMILEIFNDSCAGK-PNNVSQKYEELKSNTIYPILSTTIVIKALKSIFCIFKIENHMRALPGVDKCSVNLIEEIGMIDYDSGKWNVQKIREEIESLGY---LTE---------------------------LPKQNWNSTRQSSAVSLNEESRSKCYLRITGMTCSSCVNKVESHLLKVEGVKSVLVALLAMKCEIIYDSAYVMPFQLSNRVKELGFNAEVIENGNEGIGIVNVLIRGMTCSSCVNHIENHISKIKGIASINVSLSTSKGKVEYFISECGPRDVIDAINDMGFDASLCDHLESNHAAADHINQMIKQWRSSFFFSLICGIPXXXXXXXXXXXXXXXXHTIIHENGSNRTIMKST-VPMVCSGLSADNLILFVLATPVQFYGARYFYIQAYLSLKHKTTNMDVLVVMATXXXXXXXXXXXXXXMAFRRNTSPKTFFETSPMLIVFLSLGRWLEHIAKGKTSEALTKLMSLQAVEATLYTPEN-----KERKIPINLVQRNDLIKILPGEKIPVDGKVVTGTSTCDESLITGESMPIEKTHGSDVIGGSINKSGMLIVKATHVGSDSALAQIVKLVEEAQTSKAPIQQLADRIAGMFVPSVLICAIITLIIWVIVGFS---KPEILPKYVNELSVTEITWEHAFQLAITVLSIACPCSLGLXXXXXXXXXXXXXXXNGILIKGGEPLENIHKLNVIVFDKTGTITNGSPSVTRFLVLIGNGVREHIDKLLKILAAAESASEHPIGKAIITFSKARISNENLPEVLESSAVSGCGLGCKLNLDPKTEVTKFVKNLINIESPSEETNILGQXXXXXXXXXXXXTYKDVIFPVRQHMAWTSDLCQTVTVIIGNRNWMLRNGILVDDEVDELMSEDENLGRTVILMAIDNELIAMISVADQVKREAALAVYTLKKMNIEVYLMTGDNSKTATAIARQVGIHYVFAEVLPSHKVAKVQQLQNTNRSLTSKRKMKVAMVGDGINDSPALAQSDVGIAIGTGTDVAVEAADVVLIRNSLLDVIAAIQLSKATVKRIRQNFIAATLYNLLGIPIAAGVLMPIGIEMMPWMXXXXXXXXXXXXXXXXXXXXXWKKPSEEKLITPEYINFIQSSG---LSESQIIVRRGIDL-MTPQIETTSSLKGSVKSVLGKLNFSNKSK-HKSDKL 4116
            ++ V+GMTC SCV+NIE N+    GV  I VSL   EA + +D  + T + + ++I++MGF+ T+ S+  S   D+       RS       R+  E    +S  K+IE  +     +  ++   E   AD+   SSI + + ++           V  Q + +  +     PT         + +V + GMTC SCV NIE T+  ++GI  + V LE+       D +L  P  V E I+DMG++S     + + +   K P+ +S               +T I IK +    C+  I+  +   PGV    V+L EE G+I YD    + Q++R+ I+ +G+   +T+                           LPK N     Q    ++ E+   KC+L ++GMTC+SCV  +E +LLKV G+ SVLVAL+A K E+ YD AY+MP Q++  V ELG+ A +IEN   G G + + I GMTCSSCV+ IE+H+ K  GI S  VSL+T++G+ E+     GPRD+++ I DMG++ASL      N AA +H  +  +QWR+SF FSLI G+P M VMM+ MF +  +    +   GSN T   S  VPMV +GLS +NLILF+LATPVQF G RYFYIQAY +LKH++TNMDVL+VMAT+ISY+YSVIV+ ++M  + +TSP+TFFET+PML+VF+SLGRWLEHIAKGKTSEALTKLMSLQA EA L   +      KE++I ++LV R D++K+LPGEKIPVDGKV  G S CDESLITGESMP+EK  GS VIGGSIN++G L+V+ATHVG+DSALAQIV+LVEEAQTSKAP+Q +AD IAG FVP V   +++T ++WVIVG++   + +I  K  + +   EI ++HAF+ AITVL+IACPC+LGLATPTAVMVGTGVGA NGILIKGGEPLE  HK+  IVFDKTGTIT G   +TR L L   G+ +H+  ++ +   AE++SEHP+  AI+ ++K  +  E L +VL+  AV GCGL C++     T V   V ++   +   E TNI    +    +      Y+                     V+IGNR WM RN + V + +D+ MS  EN G T +L AI+ E++AM++VAD VK EA LAVYTLKKM + V+L+TGDN KTA AIA+QVGI  VFAEVLPSHKVAK++QLQ        K   +VAMVGDG+NDSPALAQ+D+GIAIGTGTDVAVEAA VVLIRN LLDV+AA++LSK TV+RIR NF+AAT+YN++GIP+AAG L PIGIE+MPWMASAAMAASSVSVV  SLLLKL+KKP+ E L+T EY     SSG     E  I V  G+D    P I   +SLKGS+KS++ KLN +N+ K H+ + L
Sbjct:   92 KIGVEGMTCQSCVKNIEGNMSSKPGVRHIQVSLERKEANITYDPSVVTAQMLRDQINDMGFEATLPSNGSSTSFDEFHELAKTRSHADFGKCRLHIEGMTCQSCIKNIEGVIGEFPGVKTIKVTLETKSADVTFDSSIVTAQAVADRISDMGFDCNVADQQDEFDEIASRSAPTKSPPDGTLAKCMVDIEGMTCMSCVKNIEGTLSDEKGIAQVSVSLEEKRGTVQYDPALWSPTTVAERISDMGYDS-----VVHAAAIPKVPSTIS---------------TTVISIKGMTCNSCVKTIQEVISEKPGVRSIKVSLQEEQGVIQYDPDVTSPQQLRDAIDDMGFDACITDETKFPPETTVIMNGSAGPVKSTPSRGHLPKTNHGMVLQRKVDTVEEDDLEKCHLHVSGMTCASCVANIERNLLKVPGISSVLVALMAQKAEVKYDPAYMMPSQIATLVTELGYPAMLIENEGTGDGHLEIQIGGMTCSSCVHRIESHMVKQPGIKSAIVSLATNRGRFEFDPENTGPRDIMNEIRDMGYEASLVTDNSKNSAAHEH-RKTTRQWRNSFLFSLILGVPCMVVMMYFMFAYMHMPGHQMAAGGSNDTADSSPGVPMVTAGLSVENLILFLLATPVQFIGGRYFYIQAYKALKHRSTNMDVLIVMATTISYVYSVIVVAVAMVMQESTSPRTFFETTPMLMVFISLGRWLEHIAKGKTSEALTKLMSLQASEALLLECDKNGQVIKEQRISVDLVHRGDILKVLPGEKIPVDGKVTEGHSMCDESLITGESMPVEKKKGSSVIGGSINQNGTLLVEATHVGADSALAQIVRLVEEAQTSKAPLQAVADTIAGYFVPGVCTISLLTAVVWVIVGYATYNQLDIHWKSESGMGKNEIIFQHAFKFAITVLAIACPCALGLATPTAVMVGTGVGATNGILIKGGEPLEIAHKVQSIVFDKTGTITRGIAELTR-LTLFNTGLSKHL--VIAVTGTAETSSEHPVAAAIVKYAKQALGAETLGKVLDFQAVPGCGLKCRV-----TNVDHLVSSMETKDILKEHTNIDRDEIQDLQDAPSSSGYE---------------------VLIGNREWMSRNMLTVTEAMDQEMSYHENKGETAVLCAINGEIVAMLAVADTVKEEAHLAVYTLKKMGLNVFLLTGDNLKTAKAIAKQVGISKVFAEVLPSHKVAKIKQLQ--------KDGHRVAMVGDGVNDSPALAQADLGIAIGTGTDVAVEAAGVVLIRNDLLDVVAAMRLSKKTVRRIRFNFLAATIYNIVGIPVAAGALFPIGIELMPWMASAAMAASSVSVVCSSLLLKLFKKPNREDLLTQEYFQKF-SSGRDEYGEDDISVHCGMDADFDPDIYGKTSLKGSIKSIVSKLNIANRPKGHEYNSL 1447          

Query:  283 MGFDVTVKSSEVSN------VKDKVVRSRIK-FESDIN-KSVEKSIETSLSSKLLLVRF--CQENNYADIWHYSSIRSTEILSVIQQSEIYGVLVLEQCPTIRVIVRVNGMTCQSCVDNIESTVGKKQGIISIKVFLEKSEAHALVDASLAGPD-VEEMINDMGFNSEMILEIFNDSCAGKPNNVSQKYEELKSNTIYPILSTTIVIKALKSIFCIFKIENHMRALPGVDKCSVNLIEEIGMIDYDSGKWNVQKIREEIESLGYLTELPKQNWN----STRQSSAVSLNEESRSKCYLRITGMTCSSCVNKVESHLLKVEGVKSVLVALLAMKCEIIYDSAYVMPFQLSNRVKELGFN----AEVIENGNEGIGIVNVLIRGMTCSSCVNHIENHISKIKGIASINVSLSTSKGKVEYFISECGPRDVIDAINDMGFDASLCD 1554
            MGF+  VKS   S       ++    +S +K  E  I+ +S  K I+ SLS K   +R+   Q N      H   +     L   +Q             T+ V + V GMTCQSCV NIE  +  K G+  I+V LE+ EA+   D S+     + + INDMGF + +          G   +  + +E  K+ +        + I+ +    CI  IE  +   PGV    V L  +   + +DS     Q + + I  +G+   +  Q       ++R +   S  + + +KC + I GMTC SCV  +E  L   +G+  V V+L   +  + YD A   P  ++ R+ ++G++    A  I      I    + I+GMTC+SCV  I+  IS+  G+ SI VSL   +G ++Y      P+ + DAI+DMGFDA + D
Sbjct:    1 MGFEAKVKSPGSSPQEVTIYIEGMTCQSCVKNIEGAISMRSGVKQIKVSLSQKQASIRYDPSQTNPRTLREHIDDMGFEAFLEKPKQ-------------TVNVKIGVEGMTCQSCVKNIEGNMSSKPGVRHIQVSLERKEANITYDPSVVTAQMLRDQINDMGFEATL-------PSNGSSTSFDEFHELAKTRSHADFGKCRLHIEGMTCQSCIKNIEGVIGEFPGVKTIKVTLETKSADVTFDSSIVTAQAVADRISDMGFDCNVADQQDEFDEIASRSAPTKSPPDGTLAKCMVDIEGMTCMSCVKNIEGTLSDEKGIAQVSVSLEEKRGTVQYDPALWSPTTVAERISDMGYDSVVHAAAIPKVPSTISTTVISIKGMTCNSCVKTIQEVISEKPGVRSIKVSLQEEQGVIQYDPDVTSPQQLRDAIDDMGFDACITD 423          

Query:   97 LGSARMKVDGMTCMSCVRNIEENLMKFTGVCGIMVSLLHAEATVIFDADIATVEDISNKIDEMGFDVTV------------KSSEVSNVKD-KVVRSRIKFESDINKSVEKSIETSLSSK--LLLVRFCQENNYADIWH----YSSIRSTEILSVIQQSEIYGVLVLEQCPTI--RVIVRVNGMTCQSCVDNIESTVGKKQGIISIKVFLEKSEAHALVDASLAGP-DVEEMINDMGFNSEMILE---------IFNDSCAGKPNNVSQKY---------EELKSNTIYP--ILSTTIVIKALKSIFCIFKIENHMRALPGVDKCSVNLIEEIGMIDYDSGKWNVQKIREEIESLGYLTELPKQNWNSTRQSSAVSLNEESRSKCYL--RITGMTCSSCVNKVESHLLKVEGVKSVLVALLAMKCEIIYDSAYVMPFQLSNRVKELGFNAEVIENGNE 1338
             G  R+ ++GMTC SC++NIE  + +F GV  I V+L    A V FD+ I T + ++++I +MGFD  V            +S+   +  D  + +  +  E     S  K+IE +LS +  +  V    E     + +    +S     E +S +    +     + + P+     ++ + GMTC SCV  I+  + +K G+ SIKV L++ +     D  +  P  + + I+DMGF++ +  E         I N S     +  S+ +          + K +T+    +    + +  +    C+  IE ++  +PG+    V L+ +   + YD       +I   +  LGY                A+ +  E     +L  +I GMTCSSCV+++ESH++K  G+KS +V+L   +    +D     P  + N ++++G+ A ++ + ++
Sbjct:  180 FGKCRLHIEGMTCQSCIKNIEGVIGEFPGVKTIKVTLETKSADVTFDSSIVTAQAVADRISDMGFDCNVADQQDEFDEIASRSAPTKSPPDGTLAKCMVDIEGMTCMSCVKNIEGTLSDEKGIAQVSVSLEEKRGTVQYDPALWSPTTVAERISDMGYDSVVHAAAIPKVPSTISTTVISIKGMTCNSCVKTIQEVISEKPGVRSIKVSLQEEQGVIQYDPDVTSPQQLRDAIDDMGFDACITDETKFPPETTVIMNGSAGPVKSTPSRGHLPKTNHGMVLQRKVDTVEEDDLEKCHLHVSGMTCASCVANIERNLLKVPGISSVLVALMAQKAEVKYDPAYMMPSQIATLVTELGY---------------PAMLIENEGTGDGHLEIQIGGMTCSSCVHRIESHMVKQPGIKSAIVSLATNRGRFEFDPENTGPRDIMNEIRDMGYEASLVTDNSK 622          

Query:  109 RMKVDGMTCMSCVRNIEENLMKFTGVCGIMVSLLHAEATVIFDADIATVEDISNKIDEMGFDVTVKSSEVSNVKDKV-----VRS-------RIKFESDINKSVEKSIETSLSS--KLLLVRFCQENNYADIWHYSSIRSTEILS-----------VIQQSEIYGVLVLEQCPT--------IRVIVRVNGMTCQSCVDNIESTVGKKQGIISIKVFLEKSEAHALVDASLAGPD-VEEMINDMGFNSEMILEIFNDSCAGK-PNNVSQKYEELKSNTIYPILSTTIVIKALKSIFCIFKIENHMRALPGVDKCSVNLIEEIGMIDYDSGKWNVQKIREEIESLGY---LTE---------------------------LPKQNWNSTRQSSAVSLNEESRSKCYLRITGMTCSSCVNKVESHLLKVEGVKSVLVALLAMKCEIIYDSAYVMPFQLSNRVKELGFNAEVIENGNEGIGIVNVLIRGMTCSSCVNHIENHISKIKGIASINVSLSTSKGKVEYFISECGPRDVIDAINDMGFDASLCDHLESNHAAADHINQMIKQWRSSFFFSLICGIPXXXXXXXXXXXXXXXXHTIIHENGSNRTIMKST-VPMVCSGLSADNLILFVLATPVQFYGARYFYIQAYLSLKHKTTNMDVLVVMATXXXXXXXXXXXXXXMAFRRNTSPKTFFETSPMLIVFLSLGRWLEHIAKGKTSEALTKLMSLQAVEATLYTPEN-----KERKIPINLVQRNDLIKILPGEKIPVDGKVVTGTSTCDESLITGESMPIEKTHGSDVIGGSINKSGMLIVKATHVGSDSALAQIVKLVEEAQTSKAPIQQLADRIAGMFVPSVLICAIITLIIWVIVGFS---KPEILPKYVNELSVTEITWEHAFQLAITVLSIACPCSLGLXXXXXXXXXXXXXXXNGILIKGGEPLENIHKLNVIVFDKTGTITNGSPSVTRFLVLIGNGVREHIDKLLKILAAAESASEHPIGKAIITFSKARISNENLPEVLESSAVSGCGLGCKLNLDPKTEVTKFVKNLINIESPSEETNILGQXXXXXXXXXXXXTYKDVIFPVRQHMAWTSDLCQTVTVIIGNRNWMLRNGILVDDEVDELMSEDENLGRTVILMAIDNELIAMISVADQVKREAALAVYTLKKMNIEVYLMTGDNSKTATAIARQVGIHYVFAEVLPSHKVAKVQQLQNTNRSLTSKRKMKVAMVGDGINDSPALAQSDVGIAIGTGTDVAVEAADVVLIRNSLLDVIAAIQLSKATVKRIRQNFIAATLYNLLGIPIAAGVLMPIGIEMMPWMXXXXXXXXXXXXXXXXXXXXXWKKPSEEKLITPEYINFIQSSG---LSESQIIVRRGIDL-MTPQIETTSSLKGSVKSVLGKLNFSNKSK-HKSDKL 4116
            ++ V+GMTC SCV+NIE N+    GV  I VSL   EA + +D  + T + + ++I++MGF+ T+ S+  S   D+       RS       R+  E    +S  K+IE  +     +  ++   E   AD+   SSI + + ++           V  Q + +  +     PT         + +V + GMTC SCV NIE T+  ++GI  + V LE+       D +L  P  V E I+DMG++S     + + +   K P+ +S               +T I IK +    C+  I+  +   PGV    V+L EE G+I YD    + Q++R+ I+ +G+   +T+                           LPK N     Q    ++ E+   KC+L ++GMTC+SCV  +E +LLKV G+ SVLVAL+A K E+ YD AY+MP Q++  V ELG+ A +IEN   G G + + I GMTCSSCV+ IE+H+ K  GI S  VSL+T++G+ E+     GPRD+++ I DMG++ASL      N AA +H  +  +QWR+SF FSLI G+P M VMM+ MF +  +    +   GSN T   S  VPMV +GLS +NLILF+LATPVQF G RYFYIQAY +LKH++TNMDVL+VMAT+ISY+YSVIV+ ++M  + +TSP+TFFET+PML+VF+SLGRWLEHIAKGKTSEALTKLMSLQA EA L   +      KE++I ++LV R D++K+LPGEKIPVDGKV  G S CDESLITGESMP+EK  GS VIGGSIN++G L+V+ATHVG+DSALAQIV+LVEEAQTSKAP+Q +AD IAG FVP V   +++T ++WVIVG++   + +I  K  + +   EI ++HAF+ AITVL+IACPC+LGLATPTAVMVGTGVGA NGILIKGGEPLE  HK+  IVFDKTGTIT G   +TR L L   G+ +H+  ++ +   AE++SEHP+  AI+ ++K  +  E L +VL+  AV GCGL C++     T V   V ++   +   E TNI    +    +      Y+                     V+IGNR WM RN + V + +D+ MS  EN G T +L AI+ E++AM++VAD VK EA LAVYTLKKM + V+L+TGDN KTA AIA+QVGI  VFAEVLPSHKVAK++QLQ        K   +VAMVGDG+NDSPALAQ+D+GIAIGTGTDVAVEAA VVLIRN LLDV+AA++LSK TV+RIR NF+AAT+YN++GIP+AAG L PIGIE+MPWMASAAMAASSVSVV  SLLLKL+KKP+ E L+T EY     SSG     E  I V  G+D    P I   +SLKGS+KS++ KLN +N+ K H+ + L
Sbjct:  155 KIGVEGMTCQSCVKNIEGNMSSKPGVRHIQVSLERKEANITYDPSVVTAQMLRDQINDMGFEATLPSNGSSTSFDEFHELAKTRSHADFGKCRLHIEGMTCQSCIKNIEGVIGEFPGVKTIKVTLETKSADVTFDSSIVTAQAVADRISDMGFDCNVADQQDEFDEIASRSAPTKSPPDGTLAKCMVDIEGMTCMSCVKNIEGTLSDEKGIAQVSVSLEEKRGTVQYDPALWSPTTVAERISDMGYDS-----VVHAAAIPKVPSTIS---------------TTVISIKGMTCNSCVKTIQEVISEKPGVRSIKVSLQEEQGVIQYDPDVTSPQQLRDAIDDMGFDACITDETKFPPETTVIMNGSAGPVKSTPSRGHLPKTNHGMVLQRKVDTVEEDDLEKCHLHVSGMTCASCVANIERNLLKVPGISSVLVALMAQKAEVKYDPAYMMPSQIATLVTELGYPAMLIENEGTGDGHLEIQIGGMTCSSCVHRIESHMVKQPGIKSAIVSLATNRGRFEFDPENTGPRDIMNEIRDMGYEASLVTDNSKNSAAHEH-RKTTRQWRNSFLFSLILGVPCMVVMMYFMFAYMHMPGHQMAAGGSNDTADSSPGVPMVTAGLSVENLILFLLATPVQFIGGRYFYIQAYKALKHRSTNMDVLIVMATTISYVYSVIVVAVAMVMQESTSPRTFFETTPMLMVFISLGRWLEHIAKGKTSEALTKLMSLQASEALLLECDKNGQVIKEQRISVDLVHRGDILKVLPGEKIPVDGKVTEGHSMCDESLITGESMPVEKKKGSSVIGGSINQNGTLLVEATHVGADSALAQIVRLVEEAQTSKAPLQAVADTIAGYFVPGVCTISLLTAVVWVIVGYATYNQLDIHWKSESGMGKNEIIFQHAFKFAITVLAIACPCALGLATPTAVMVGTGVGATNGILIKGGEPLEIAHKVQSIVFDKTGTITRGIAELTR-LTLFNTGLSKHL--VIAVTGTAETSSEHPVAAAIVKYAKQALGAETLGKVLDFQAVPGCGLKCRV-----TNVDHLVSSMETKDILKEHTNIDRDEIQDLQDVSSSSGYE---------------------VLIGNREWMSRNMLTVTEAMDQEMSYHENKGETAVLCAINGEIVAMLAVADTVKEEAHLAVYTLKKMGLNVFLLTGDNLKTAKAIAKQVGISKVFAEVLPSHKVAKIKQLQ--------KDGHRVAMVGDGVNDSPALAQADLGIAIGTGTDVAVEAAGVVLIRNDLLDVVAAMRLSKKTVRRIRFNFLAATIYNIVGIPVAAGALFPIGIELMPWMASAAMAASSVSVVCSSLLLKLFKKPNREDLLTQEYFQKF-SSGRDEYGEDDISVHCGMDADFDPDIYGKTSLKGSIKSIVSKLNIANRPKGHEYNSL 1510          

Query:   97 LGSARMKVDGMTCMSCVRNIEENLMKFTGVCGIMVSLLHAEATVIFDADIATVEDISNKIDEMGFDVTVKSSEVSN------VKDKVVRSRIK-FESDIN-KSVEKSIETSLSSKLLLVRF--CQENNYADIWHYSSIRSTEILSVIQQSEIYGVLVLEQCPTIRVIVRVNGMTCQSCVDNIESTVGKKQGIISIKVFLEKSEAHALVDASLAGPD-VEEMINDMGFNSEMILEIFNDSCAGKPNNVSQKYEELKSNTIYPILSTTIVIKALKSIFCIFKIENHMRALPGVDKCSVNLIEEIGMIDYDSGKWNVQKIREEIESLGYLTELPKQNWN----STRQSSAVSLNEESRSKCYLRITGMTCSSCVNKVESHLLKVEGVKSVLVALLAMKCEIIYDSAYVMPFQLSNRVKELGFN----AEVIENGNEGIGIVNVLIRGMTCSSCVNHIENHISKIKGIASINVSLSTSKGKVEYFISECGPRDVIDAINDMGFDASLCD 1554
            +  A + + GMTC SCV+NIE N+  F G+  I VSL + E  V FD  + T E I+  ID+MGF+  VKS   S       ++    +S +K  E  I+ +S  K I+ SLS K   +R+   Q N      H   +     L   +Q             T+ V + V GMTCQSCV NIE  +  K G+  I+V LE+ EA+   D S+     + + INDMGF + +          G   +  + +E  K+ +        + I+ +    CI  IE  +   PGV    V L  +   + +DS     Q + + I  +G+   +  Q       ++R +   S  + + +KC + I GMTC SCV  +E  L   +G+  V V+L   +  + YD A   P  ++ R+ ++G++    A  I      I    + I+GMTC+SCV  I+  IS+  G+ SI VSL   +G ++Y      P+ + DAI+DMGFDA + D
Sbjct:    2 MSEAVISIQGMTCQSCVKNIEVNMAAFPGISTIEVSLENQEGVVSFDPTVTTAEKIAEGIDDMGFEAKVKSPGSSPQEVTIYIEGMTCQSCVKNIEGAISMRSGVKQIKVSLSQKQASIRYDPSQTNPRTLREHIDDMGFEAFLEKPKQ-------------TVNVKIGVEGMTCQSCVKNIEGNMSSKPGVRHIQVSLERKEANITYDPSVVTAQMLRDQINDMGFEATL-------PSNGSSTSFDEFHELAKTRSHADFGKCRLHIEGMTCQSCIKNIEGVIGEFPGVKTIKVTLETKSADVTFDSSIVTAQAVADRISDMGFDCNVADQQDEFDEIASRSAPTKSPPDGTLAKCMVDIEGMTCMSCVKNIEGTLSDEKGIAQVSVSLEEKRGTVQYDPALWSPTTVAERISDMGYDSVVHAAAIPKVPSTISTTVISIKGMTCNSCVKTIQEVISEKPGVRSIKVSLQEEQGVIQYDPDVTSPQQLRDAIDDMGFDACITD 486          

Query:  109 RMKVDGMTCMSCVRNIEENLMKFTGVCGIMVSLLHAEATVIFDADIATVEDISNKIDEMGFDVTVKSSEVSNVKDKV-----VRS-------RIKFESDINKSVEKSIETSLSS--KLLLVRFCQENNYADIWHYSSIRSTEILS-----------VIQQSEIYGVLVLEQCPT--------IRVIVRVNGMTCQSCVDNIESTVGKKQGIISIKVFLEKSEAHALVDASLAGPD-VEEMINDMGFNSEMILEIFNDSCAGK-PNNVSQKYEELKSNTIYPILSTTIVIKALKSIFCIFKIENHMRALPGVDKCSVNLIEEIGMIDYDSGKWNVQKIREEIESLGY---LTE---------------------------LPKQNWNSTRQSSAVSLNEESRSKCYLRITGMTCSSCVNKVESHLLKVEGVKSVLVALLAMKCEIIYDSAYVMPFQLSNRVKELGFNAEVIENGNEGIGIVNVLIRGMTCSSCVNHIENHISKIKGIASINVSLSTSKGKVEYFISECGPRDVIDAINDMGFDASLCDHLESNHAAADHINQMIKQWRSSFFFSLICGIPXXXXXXXXXXXXXXXXHTIIHENGSNRTIMKST-VPMVCSGLSADNLILFVLATPVQFYGARYFYIQAYLSLKHKTTNMDVLVVMATXXXXXXXXXXXXXXMAFRRNTSPKTFFETSPMLIVFLSLGRWLEHIAKGKTSEALTKLMSLQAVEATLYTPEN-----KERKIPINLVQRNDLIKILPGEKIPVDGKVVTGTSTCDESLITGESMPIEKTHGSDVIGGSINKSGMLIVKATHVGSDSALAQIVKLVEEAQTSKAPIQQLADRIAGMFVPSVLICAIITLIIWVIVGFS---KPEILPKYVNELSVTEITWEHAFQLAITVLSIACPCSLGLXXXXXXXXXXXXXXXNGILIKGGEPLENIHKLNVIVFDKTGTITNGSPSVTRFLVLIGNGVREHIDKLLKILAAAESASEHPIGKAIITFSKARISNENLPEVLESSAVSGCGLGCKLNLDPKTEVTKFVKNLINIESPSEETNILGQXXXXXXXXXXXXTYKDVIFPVRQHMAWTSDLCQTVTVIIGNRNWMLRNGILVDDEVDELMSEDENLGRTVILMAIDNELIAMISVADQVKREAALAVYTLKKMNIEVYLMTGDNSKTATAIARQVGIHYVFAEVLPSHKVAKVQQLQNTNRSLTSKRKMKVAMVGDGINDSPALAQSDVGIAIGTGTDVAVEAADVVLIRNSLLDVIAAIQLSKATVKRIRQNFIAATLYNLLGIPIAAGVLMPIGIEMMPWMXXXXXXXXXXXXXXXXXXXXXWKKPSEEKLITPEYINFIQSSG---LSESQIIVRRGIDL-MTPQIETTSSLKGSVKSVLGKLNFSNKSK-HKSDKL 4116
            ++ V+GMTC SCV+NIE N+    GV  I VSL   EA + +D  + T + + ++I++MGF+ T+ S+  S   D+       RS       R+  E    +S  K+IE  +     +  ++   E   AD+   SSI + + ++           V  Q + +  +     PT         + +V + GMTC SCV NIE T+  ++GI  + V LE+       D +L  P  V E I+DMG++S     + + +   K P+ +S               +T I IK +    C+  I+  +   PGV    V+L EE G+I YD    + Q++R+ I+ +G+   +T+                           LPK N     Q    ++ E+   KC+L ++GMTC+SCV  +E +LLKV G+ SVLVAL+A K E+ YD AY+MP Q++  V ELG+ A +IEN   G G + + I GMTCSSCV+ IE+H+ K  GI S  VSL+T++G+ E+     GPRD+++ I DMG++ASL      N AA +H  +  +QWR+SF FSLI G+P M VMM+ MF +  +    +   GSN T   S  VPMV +GLS +NLILF+LATPVQF G RYFYIQAY +LKH++TNMDVL+VMAT+ISY+YSVIV+ ++M  + +TSP+TFFET+PML+VF+SLGRWLEHIAKGKTSEALTKLMSLQA EA L   +      KE++I ++LV R D++K+LPGEKIPVDGKV  G S CDESLITGESMP+EK  GS VIGGSIN++G L+V+ATHVG+DSALAQIV+LVEEAQTSKAP+Q +AD IAG FVP V   +++T ++WVIVG++   + +I  K  + +   EI ++HAF+ AITVL+IACPC+LGLATPTAVMVGTGVGA NGILIKGGEPLE  HK+  IVFDKTGTIT G   +TR L L   G+ +H+  ++ +   AE++SEHP+  AI+ ++K  +  E L +VL+  AV GCGL C++     T V   V ++   +   E TNI    +    +      Y+                     V+IGNR WM RN + V + +D+ MS  EN G T +L AI+ E++AM++VAD VK EA LAVYTLKKM + V+L+TGDN KTA AIA+QVGI  VFAEVLPSHKVAK++QLQ        K   +VAMVGDG+NDSPALAQ+D+GIAIGTGTDVAVEAA VVLIRN LLDV+AA++LSK TV+RIR NF+AAT+YN++GIP+AAG L PIGIE+MPWMASAAMAASSVSVV  SLLLKL+KKP+ E L+T EY     SSG     E  I V  G+D    P I   +SLKGS+KS++ KLN +N+ K H+ + L
Sbjct:  155 KIGVEGMTCQSCVKNIEGNMSSKPGVRHIQVSLERKEANITYDPSVVTAQMLRDQINDMGFEATLPSNGSSTSFDEFHELAKTRSHADFGKCRLHIEGMTCQSCIKNIEGVIGEFPGVKTIKVTLETKSADVTFDSSIVTAQAVADRISDMGFDCNVADQQDEFDEIASRSAPTKSPPDGTLAKCMVDIEGMTCMSCVKNIEGTLSDEKGIAQVSVSLEEKRGTVQYDPALWSPTTVAERISDMGYDS-----VVHAAAIPKVPSTIS---------------TTVISIKGMTCNSCVKTIQEVISEKPGVRSIKVSLQEEQGVIQYDPDVTSPQQLRDAIDDMGFDACITDETKFPPETTVIMNGSAGPVKSTPSRGHLPKTNHGMVLQRKVDTVEEDDLEKCHLHVSGMTCASCVANIERNLLKVPGISSVLVALMAQKAEVKYDPAYMMPSQIATLVTELGYPAMLIENEGTGDGHLEIQIGGMTCSSCVHRIESHMVKQPGIKSAIVSLATNRGRFEFDPENTGPRDIMNEIRDMGYEASLVTDNSKNSAAHEH-RKTTRQWRNSFLFSLILGVPCMVVMMYFMFAYMHMPGHQMAAGGSNDTADSSPGVPMVTAGLSVENLILFLLATPVQFIGGRYFYIQAYKALKHRSTNMDVLIVMATTISYVYSVIVVAVAMVMQESTSPRTFFETTPMLMVFISLGRWLEHIAKGKTSEALTKLMSLQASEALLLECDKNGQVIKEQRISVDLVHRGDILKVLPGEKIPVDGKVTEGHSMCDESLITGESMPVEKKKGSSVIGGSINQNGTLLVEATHVGADSALAQIVRLVEEAQTSKAPLQAVADTIAGYFVPGVCTISLLTAVVWVIVGYATYNQLDIHWKSESGMGKNEIIFQHAFKFAITVLAIACPCALGLATPTAVMVGTGVGATNGILIKGGEPLEIAHKVQSIVFDKTGTITRGIAELTR-LTLFNTGLSKHL--VIAVTGTAETSSEHPVAAAIVKYAKQALGAETLGKVLDFQAVPGCGLKCRV-----TNVDHLVSSMETKDILKEHTNIDRDEIQDLQDAPSSSGYE---------------------VLIGNREWMSRNMLTVTEAMDQEMSYHENKGETAVLCAINGEIVAMLAVADTVKEEAHLAVYTLKKMGLNVFLLTGDNLKTAKAIAKQVGISKVFAEVLPSHKVAKIKQLQ--------KDGHRVAMVGDGVNDSPALAQADLGIAIGTGTDVAVEAAGVVLIRNDLLDVVAAMRLSKKTVRRIRFNFLAATIYNIVGIPVAAGALFPIGIELMPWMASAAMAASSVSVVCSSLLLKLFKKPNREDLLTQEYFQKF-SSGRDEYGEDDISVHCGMDADFDPDIYGKTSLKGSIKSIVSKLNIANRPKGHEYNSL 1510          

Query:   97 LGSARMKVDGMTCMSCVRNIEENLMKFTGVCGIMVSLLHAEATVIFDADIATVEDISNKIDEMGFDVTVKSSEVSN------VKDKVVRSRIK-FESDIN-KSVEKSIETSLSSKLLLVRF--CQENNYADIWHYSSIRSTEILSVIQQSEIYGVLVLEQCPTIRVIVRVNGMTCQSCVDNIESTVGKKQGIISIKVFLEKSEAHALVDASLAGPD-VEEMINDMGFNSEMILEIFNDSCAGKPNNVSQKYEELKSNTIYPILSTTIVIKALKSIFCIFKIENHMRALPGVDKCSVNLIEEIGMIDYDSGKWNVQKIREEIESLGYLTELPKQNWN----STRQSSAVSLNEESRSKCYLRITGMTCSSCVNKVESHLLKVEGVKSVLVALLAMKCEIIYDSAYVMPFQLSNRVKELGFN----AEVIENGNEGIGIVNVLIRGMTCSSCVNHIENHISKIKGIASINVSLSTSKGKVEYFISECGPRDVIDAINDMGFDASLCD 1554
            +  A + + GMTC SCV+NIE N+  F G+  I VSL + E  V FD  + T E I+  ID+MGF+  VKS   S       ++    +S +K  E  I+ +S  K I+ SLS K   +R+   Q N      H   +     L   +Q             T+ V + V GMTCQSCV NIE  +  K G+  I+V LE+ EA+   D S+     + + INDMGF + +          G   +  + +E  K+ +        + I+ +    CI  IE  +   PGV    V L  +   + +DS     Q + + I  +G+   +  Q       ++R +   S  + + +KC + I GMTC SCV  +E  L   +G+  V V+L   +  + YD A   P  ++ R+ ++G++    A  I      I    + I+GMTC+SCV  I+  IS+  G+ SI VSL   +G ++Y      P+ + DAI+DMGFDA + D
Sbjct:    2 MSEAVISIQGMTCQSCVKNIEVNMAAFPGISTIEVSLENQEGVVSFDPTVTTAEKIAEGIDDMGFEAKVKSPGSSPQEVTIYIEGMTCQSCVKNIEGAISMRSGVKQIKVSLSQKQASIRYDPSQTNPRTLREHIDDMGFEAFLEKPKQ-------------TVNVKIGVEGMTCQSCVKNIEGNMSSKPGVRHIQVSLERKEANITYDPSVVTAQMLRDQINDMGFEATL-------PSNGSSTSFDEFHELAKTRSHADFGKCRLHIEGMTCQSCIKNIEGVIGEFPGVKTIKVTLETKSADVTFDSSIVTAQAVADRISDMGFDCNVADQQDEFDEIASRSAPTKSPPDGTLAKCMVDIEGMTCMSCVKNIEGTLSDEKGIAQVSVSLEEKRGTVQYDPALWSPTTVAERISDMGYDSVVHAAAIPKVPSTISTTVISIKGMTCNSCVKTIQEVISEKPGVRSIKVSLQEEQGVIQYDPDVTSPQQLRDAIDDMGFDACITD 486          

Query:  118 VDGMTCMSCVRNIEENLMKFTGVCGIMVSLLHAEATVIFDADIATVEDISNKIDEMGFDVTV-KSSEVSNVKDKVVRSRIKFESDINKSVEKSIETSLSSK--LLLVRFCQENNYADIWHYSSIRSTEILS---------------------VIQQSEIYGVLVLEQCPT----IRVIVRVNGMTCQSCVDNIESTVGKKQGIISIKVFLEKSEAHALVDASLAGP-DVEEMINDMGFNSEMILEIFNDSCAGK-PNNVSQKYEELKSNTIYPILSTTIVIKALKSIFCIFKIENHMRALPGVDKCSVNLIEEIGMIDYDSGKWNVQKIREEIESLGY---LTE---------------------------LPKQNWNSTRQSSAVSLNEESRSKCYLRITGMTCSSCVNKVESHLLKVEGVKSVLVALLAMKCEIIYDSAYVMPFQLSNRVKELGFNAEVIENGNEGIGIVNVLIRGMTCSSCVNHIENHISKIKGIASINVSLSTSKGKVEYFISECGPRDVIDAINDMGFDASLCDHLESNHAAADHINQMIKQWRSSFFFSLICGIPXXXXXXXXXXXXXXXXHTIIHENGSNRTIMKST-VPMVCSGLSADNLILFVLATPVQFYGARYFYIQAYLSLKHKTTNMDVLVVMATXXXXXXXXXXXXXXMAFRRNTSPKTFFETSPMLIVFLSLGRWLEHIAKGKTSEALTKLMSLQAVEATLYTPEN-----KERKIPINLVQRNDLIKILPGEKIPVDGKVVTGTSTCDESLITGESMPIEKTHGSDVIGGSINKSGMLIVKATHVGSDSALAQIVKLVEEAQTSKAPIQQLADRIAGMFVPSVLICAIITLIIWVIVGFS---KPEILPKYVNELSVTEITWEHAFQLAITVLSIACPCSLGLXXXXXXXXXXXXXXXNGILIKGGEPLENIHKLNVIVFDKTGTITNGSPSVTRFLVLIGNGVREHIDKLLKILAAAESASEHPIGKAIITFSKARISNENLPEVLESSAVSGCGLGCKLNLDPKTEVTKFVKNLINIESPSEETNILGQXXXXXXXXXXXXTYKDVIFPVRQHMAWTSDLCQTVTVIIGNRNWMLRNGILVDDEVDELMSEDENLGRTVILMAIDNELIAMISVADQVKREAALAVYTLKKMNIEVYLMTGDNSKTATAIARQVGIHYVFAEVLPSHKVAKVQQLQNTNRSLTSKRKMKVAMVGDGINDSPALAQSDVGIAIGTGTDVAVEAADVVLIRNSLLDVIAAIQLSKATVKRIRQNFIAATLYNLLGIPIAAGVLMPIGIEMMPWMXXXXXXXXXXXXXXXXXXXXXWKKPSEEKLITPEYINFIQSSG---LSESQIIVRRGIDL-MTPQIETTSSLKGSVKSVLGKLNFSNKSK-HKSDKL 4116
            ++GMTC SCV+NIE  +   +GV  I VSL   +A++ +D        +   ID+MGF+  + K  + +NVK       I  E    +S  K+IE ++SSK  +  ++   E   A+I +  S+ + ++L                        +  EI G     + P+     + +V + GMTC SCV NIE T+  ++GI  + V LE+       D +L  P  V E I+DMG++S     + + S   K P+ +S               +T I IK +    C+  I+  +   PGV    V+L EE G+I YD    + Q++R+ I+ +G+   +T+                           LPK N     Q    ++ E+   KC+L ++GMTC+SCV  +E +LLKV G+ SVLVAL+A K E+ YD AY+MP Q++  V ELG+ A +IEN   G G + + I GMTCSSCV+ IE+H+ K  GI S  VSL+T++G+ E+     GPRD+++ I DMG++ASL      N AA +H  +  +QWR+SF FSLI G+P M VMM+ MF +  +    +   GSN T   S  VPMV +GLS +NLILF+LATPVQF G RYFYIQAY +LKH++TNMDVL+VMAT+ISY+YSVIV+ ++M  + +TSP+TFFET+PML+VF+SLGRWLEHIAKGKTSEALTKLMSLQA EA L   +      KE++I ++LV R D++K+LPGEKIPVDGKV  G S CDESLITGESMP+EK  GS VIGGSIN++G L+V+ATHVG+DSALAQIV+LVEEAQTSKAP+Q +AD IAG FVP V   +++T ++WVIVG++   + +I  K  + +   EI ++HAF+ AITVL+IACPC+LGLATPTAVMVGTGVGA NGILIKGGEPLE  HK+  IVFDKTGTIT G   +TR L L   G+ +H+  ++ +   AE++SEHP+  AI+ ++K  +  E L +VL+  AV GCGL C++     T V   V ++   +   E TNI    +    +      Y+                     V+IGNR WM RN + V +++D+ MS  EN G T +L AI+ E++AM++VAD VK EA LAVYTLKKM + V+L+TGDN KTA AIA+QVGI  VFAEVLPSHKVAK++QLQ        K   +VAMVGDG+NDSPALAQ+D+GIAIGTGTDVAVEAA VVLIRN LLDV+AA++LSK TV+RIR NF+AAT+YN++GIP+AAG L PIGIE+MPWMASAAMAASSVSVV  SLLLKL+KKP+ E L+T EY     SSG     E  I V  G+D    P I   +SLKGS+KS++ KLN +N+ K H+ + L
Sbjct:   84 IEGMTCQSCVKNIEGAISMRSGVKQIKVSLSQKQASIRYDPSQTNPRTLREHIDDMGFEAFLEKPKQTANVK-------IGVEGMTCQSCVKNIEGNMSSKPGVRHIQVSLERKEANITYDPSVVTAQMLRDQIDDMGFEATLPSHGSSTSLEDEFDEIAGRSAPTKSPSDGTLAKCMVDIEGMTCMSCVKNIEGTLSDEKGIAQVSVSLEEKRGTVQYDPALWSPATVAERISDMGYDS-----VVHASAIPKVPSTIS---------------TTVISIKGMTCNSCVKTIQEVISEKPGVRSIKVSLQEEQGVIQYDPDVTSPQQLRDAIDDMGFDACITDETKFPPETTVIMNGSAGPVKSTPSRGHLPKTNHGVVIQRKVDTVEEDDLEKCHLHVSGMTCASCVANIERNLLKVPGISSVLVALMAQKAEVKYDPAYMMPSQIATMVTELGYPAMLIENEGTGDGHLEIQIGGMTCSSCVHRIESHMVKQPGIKSAIVSLATNRGRFEFDPENTGPRDIMNEIRDMGYEASLVTDNSKNSAAHEH-RKTTRQWRNSFLFSLILGVPCMVVMMYFMFAYMHMPGHQMAAGGSNDTADSSPGVPMVTAGLSVENLILFLLATPVQFIGGRYFYIQAYKALKHRSTNMDVLIVMATTISYVYSVIVVAVAMVMQESTSPRTFFETTPMLMVFISLGRWLEHIAKGKTSEALTKLMSLQASEALLLECDKNGQVIKEQRISVDLVHRGDILKVLPGEKIPVDGKVTEGHSMCDESLITGESMPVEKKKGSSVIGGSINQNGTLLVEATHVGADSALAQIVRLVEEAQTSKAPLQAVADTIAGYFVPGVCTISLLTAVVWVIVGYATYNQLDIHWKSESGMGKNEIIFQHAFKFAITVLAIACPCALGLATPTAVMVGTGVGATNGILIKGGEPLEIAHKVQSIVFDKTGTITRGIAELTR-LTLFNTGLSKHL--VIAVTGTAETSSEHPVAAAIVKYAKQALGAETLGKVLDFQAVPGCGLKCRV-----TNVDHLVSSMETKDILKEHTNIDRDEIQDLQDAPCSSGYE---------------------VLIGNREWMSRNMLTVTEDMDQEMSYHENKGETAVLCAINGEIVAMLAVADTVKEEAHLAVYTLKKMGLNVFLLTGDNLKTAKAIAKQVGISKVFAEVLPSHKVAKIKQLQ--------KDGHRVAMVGDGVNDSPALAQADLGIAIGTGTDVAVEAAGVVLIRNDLLDVVAAMRLSKKTVRRIRFNFLAATIYNIVGIPVAAGALFPIGIELMPWMASAAMAASSVSVVCSSLLLKLFKKPNREDLLTQEYFQKF-SSGRDEYGEDDISVHCGMDADFDPDIYGKTSLKGSIKSIVSKLNIANRPKGHEYNSL 1424          

Query:   97 LGSARMKVDGMTCMSCVRNIEENLMKFTGVCGIMVSLLHAEATVIFDADIATVEDISNKIDEMGFDVTVKSSEVSN------VKDKVVRSRIK-FESDIN-KSVEKSIETSLSSKLLLVRF--CQENNYADIWHYSSIRSTEILSVIQQSEIYGVLVLEQCPTIRVIVRVNGMTCQSCVDNIESTVGKKQGIISIKVFLEKSEAHALVDASLAGPD-VEEMINDMGFNSEMILEIFNDSCAGKPNNVSQKYEELKSNTIYPILSTTIVIKALKSIFCIFKIENHMRALPGVDKCSVNLIEEIGMIDYDSGKWNVQKIREEIESLGYLTELPKQNWNSTRQSSAVSLNEESRSKCYLRITGMTCSSCVNKVESHLLKVEGVKSVLVALLAMKCEIIYDSAYVMPFQLSNRVKELGFNA------------EVIENGNEGI---------------GIV----------------NVLIRGMTCSSCVNHIENHISKIKGIASINVSLSTSKGKVEYFISECGPRDVIDAINDMGFDASLCDH 1557
            +  A + + GMTC SCV+NIE N+  F G+  I VSL + E  V FD  + T E I+  ID+MGF+  VKS   S       ++    +S +K  E  I+ +S  K I+ SLS K   +R+   Q N      H   +     L   +Q             T  V + V GMTCQSCV NIE  +  K G+  I+V LE+ EA+   D S+     + + I+DMGF + +     + S   + + ++ +    KS +   +    + I+ +  + C+  IE  +    G+ + SV+L E+ G + YD   W+   + E I  +GY         +S   +SA+     + S   + I GMTC+SCV  ++  + +  GV+S+ V+L   +  I YD     P QL + + ++GF+A             VI NG+ G                G+V                ++ + GMTC+SCV +IE ++ K+ GI+S+ V+L   K +V+Y  +   P  +   + ++G+ A L ++
Sbjct:    2 MSEAVISIQGMTCQSCVKNIEVNMAAFPGISTIEVSLENQEGVVSFDPTVTTAEKIAEGIDDMGFEAKVKSPGSSPQEVTIYIEGMTCQSCVKNIEGAISMRSGVKQIKVSLSQKQASIRYDPSQTNPRTLREHIDDMGFEAFLEKPKQ-------------TANVKIGVEGMTCQSCVKNIEGNMSSKPGVRHIQVSLERKEANITYDPSVVTAQMLRDQIDDMGFEATLPSHGSSTSLEDEFDEIAGRSAPTKSPSDGTLAKCMVDIEGMTCMSCVKNIEGTLSDEKGIAQVSVSLEEKRGTVQYDPALWSPATVAERISDMGY---------DSVVHASAIPKVPSTISTTVISIKGMTCNSCVKTIQEVISEKPGVRSIKVSLQEEQGVIQYDPDVTSPQQLRDAIDDMGFDACITDETKFPPETTVIMNGSAGPVKSTPSRGHLPKTNHGVVIQRKVDTVEEDDLEKCHLHVSGMTCASCVANIERNLLKVPGISSVLVALMAQKAEVKYDPAYMMPSQIATMVTELGYPAMLIEN 520          

Query:  109 RMKVDGMTCMSCVRNIEENLMKFTGVCGIMVSLLHAEATVIFDADIATVEDISNKIDEMGFDVTVKSSEVSNVKDKV-----VRS-------RIKFESDINKSVEKSIETSLSS--KLLLVRFCQENNYADIWHYSSIRSTEILS-----------VIQQSEIYGVLVLEQCPT--------IRVIVRVNGMTCQSCVDNIESTVGKKQGIISIKVFLEKSEAHALVDASLAGPD-VEEMINDMGFNSEMILEIFNDSCAGK-PNNVSQKYEELKSNTIYPILSTTIVIKALKSIFCIFKIENHMRALPGVDKCSVNLIEEIGMIDYDSGKWNVQKIREEIESLGY---LTE---------------------------LPKQNWNSTRQSSAVSLNEESRSKCYLRITGMTCSSCVNKVESHLLKVEGVKSVLVALLAMKCEIIYDSAYVMPFQLSNRVKELGFNAEVIENGNEGIGIVNVLIRGMTCSSCVNHIENHISKIKGIASINVSLSTSKGKVEYFISECGPRDVIDAINDMGFDASLCDHLESNHAAADHINQMIKQWRSSFFFSLICGIPXXXXXXXXXXXXXXXXHTIIHENGSNRTIMKST-VPMVCSGLSADNLILFVLATPVQFYGARYFYIQAYLSLKHKTTNMDVLVVMATXXXXXXXXXXXXXXMAFRRNTSPKTFFETSPMLIVFLSLGRWLEHIAKGKTSEALTKLMSLQAVEATLYTPEN-----KERKIPINLVQRNDLIKILPGEKIPVDGKVVTGTSTCDESLITGESMPIEKTHGSDVIGGSINKSGMLIVKATHVGSDSALAQIVKLVEEAQTSKAPIQQLADRIAGMFVPSVLICAIITLIIWVIVGFS---KPEILPKYVNELSVTEITWEHAFQLAITVLSIACPCSLGLXXXXXXXXXXXXXXXNGILIKGGEPLENIHKLNVIVFDKTGTITNGSPSVTRFLVLIGNGVREHIDKLLKILAAAESASEHPIGKAIITFSKARISNENLPEVLESSAVSGCGLGCKLNLDPKTEVTKFVKNLINIESPSEETNILGQXXXXXXXXXXXXTYKDVIFPVRQHMAWTSDLCQTVTVIIGNRNWMLRNGILVDDEVDELMSEDENLGRTVILMAIDNELIAMISVADQVKREAALAVYTLKKMNIEVYLMTGDNSKTATAIARQVGIHYVFAEVLPSHKVAKVQQLQNTNRSLTSKRKMKVAMVGDGINDSPALAQSDVGIAIGTGTDVAVEAADVVLIRNSLLDVIAAIQLSKATVKRIRQNFIAATLYNLLGIPIAAGVLMPIGIEMMPWMXXXXXXXXXXXXXXXXXXXXXWKKPSEEKLITPEYINFIQSS 3966
            ++ V+GMTC SCV+NIE N+    GV  I VSL   EA + +D  + T + + ++I++MGF+ T+ S+  S   D+       RS       R+  E    +S  K+IE  +     +  ++   E   AD+   SSI + + ++           V  Q + +  +     PT         + +V + GMTC SCV NIE T+  ++GI  + V LE+       D +L  P  V E I+DMG++S     + + +   K P+ +S               +T I IK +    C+  I+  +   PGV    V+L EE G+I YD    + Q++R+ I+ +G+   +T+                           LPK N     Q    ++ E+   KC+L ++GMTC+SCV  +E +LLKV G+ SVLVAL+A K E+ YD AY+MP Q++  V ELG+ A +IEN   G G + + I GMTCSSCV+ IE+H+ K  GI S  VSL+T++G+ E+     GPRD+++ I DMG++ASL      N AA +H  +  +QWR+SF FSLI G+P M VMM+ MF +  +    +   GSN T   S  VPMV +GLS +NLILF+LATPVQF G RYFYIQAY +LKH++TNMDVL+VMAT+ISY+YSVIV+ ++M  + +TSP+TFFET+PML+VF+SLGRWLEHIAKGKTSEALTKLMSLQA EA L   +      KE++I ++LV R D++K+LPGEKIPVDGKV  G S CDESLITGESMP+EK  GS VIGGSIN++G L+V+ATHVG+DSALAQIV+LVEEAQTSKAP+Q +AD IAG FVP V   +++T ++WVIVG++   + +I  K  + +   EI ++HAF+ AITVL+IACPC+LGLATPTAVMVGTGVGA NGILIKGGEPLE  HK+  IVFDKTGTIT G   +TR L L   G+ +H+  ++ +   AE++SEHP+  AI+ ++K  +  E L +VL+  AV GCGL C++     T V   V ++   +   E TNI    +    +      Y+                     V+IGNR WM RN + V + +D+ MS  EN G T +L AI+ E++AM++VAD VK EA LAVYTLKKM + V+L+TGDN KTA AIA+QVGI  VFAEVLPSHKVAK++QLQ        K   +VAMVGDG+NDSPALAQ+D+GIAIGTGTDVAVEAA VVLIRN LLDV+AA++LSK TV+RIR NF+AAT+YN++GIP+AAG L PIGIE+MPWMASAAMAASSVSVV  SLLLKL+K P  E L+T EY   +Q +
Sbjct:  155 KIGVEGMTCQSCVKNIEGNMSSKPGVRHIQVSLERKEANITYDPSVVTAQMLRDQINDMGFEATLPSNGSSTSFDEFHELAKTRSHADFGKCRLHIEGMTCQSCIKNIEGVIGEFPGVKTIKVTLETKSADVTFDSSIVTAQAVADRISDMGFDCNVADQQDEFDEIASRSAPTKSPPDGTLAKCMVDIEGMTCMSCVKNIEGTLSDEKGIAQVSVSLEEKRGTVQYDPALWSPTTVAERISDMGYDS-----VVHAAAIPKVPSTIS---------------TTVISIKGMTCNSCVKTIQEVISEKPGVRSIKVSLQEEQGVIQYDPDVTSPQQLRDAIDDMGFDACITDETKFPPETTVIMNGSAGPVKSTPSRGHLPKTNHGMVLQRKVDTVEEDDLEKCHLHVSGMTCASCVANIERNLLKVPGISSVLVALMAQKAEVKYDPAYMMPSQIATLVTELGYPAMLIENEGTGDGHLEIQIGGMTCSSCVHRIESHMVKQPGIKSAIVSLATNRGRFEFDPENTGPRDIMNEIRDMGYEASLVTDNSKNSAAHEH-RKTTRQWRNSFLFSLILGVPCMVVMMYFMFAYMHMPGHQMAAGGSNDTADSSPGVPMVTAGLSVENLILFLLATPVQFIGGRYFYIQAYKALKHRSTNMDVLIVMATTISYVYSVIVVAVAMVMQESTSPRTFFETTPMLMVFISLGRWLEHIAKGKTSEALTKLMSLQASEALLLECDKNGQVIKEQRISVDLVHRGDILKVLPGEKIPVDGKVTEGHSMCDESLITGESMPVEKKKGSSVIGGSINQNGTLLVEATHVGADSALAQIVRLVEEAQTSKAPLQAVADTIAGYFVPGVCTISLLTAVVWVIVGYATYNQLDIHWKSESGMGKNEIIFQHAFKFAITVLAIACPCALGLATPTAVMVGTGVGATNGILIKGGEPLEIAHKVQSIVFDKTGTITRGIAELTR-LTLFNTGLSKHL--VIAVTGTAETSSEHPVAAAIVKYAKQALGAETLGKVLDFQAVPGCGLKCRV-----TNVDHLVSSMETKDILKEHTNIDRDEIQDLQDAPSSSGYE---------------------VLIGNREWMSRNMLTVTEAMDQEMSYHENKGETAVLCAINGEIVAMLAVADTVKEEAHLAVYTLKKMGLNVFLLTGDNLKTAKAIAKQVGISKVFAEVLPSHKVAKIKQLQ--------KDGHRVAMVGDGVNDSPALAQADLGIAIGTGTDVAVEAAGVVLIRNDLLDVVAAMRLSKKTVRRIRFNFLAATIYNIVGIPVAAGALFPIGIELMPWMASAAMAASSVSVVCSSLLLKLFKMPRPEDLLTSEYKARLQET 1456          

Query:   97 LGSARMKVDGMTCMSCVRNIEENLMKFTGVCGIMVSLLHAEATVIFDADIATVEDISNKIDEMGFDVTVKSSEVSN------VKDKVVRSRIK-FESDIN-KSVEKSIETSLSSKLLLVRF--CQENNYADIWHYSSIRSTEILSVIQQSEIYGVLVLEQCPTIRVIVRVNGMTCQSCVDNIESTVGKKQGIISIKVFLEKSEAHALVDASLAGPD-VEEMINDMGFNSEMILEIFNDSCAGKPNNVSQKYEELKSNTIYPILSTTIVIKALKSIFCIFKIENHMRALPGVDKCSVNLIEEIGMIDYDSGKWNVQKIREEIESLGYLTELPKQNWN----STRQSSAVSLNEESRSKCYLRITGMTCSSCVNKVESHLLKVEGVKSVLVALLAMKCEIIYDSAYVMPFQLSNRVKELGFN----AEVIENGNEGIGIVNVLIRGMTCSSCVNHIENHISKIKGIASINVSLSTSKGKVEYFISECGPRDVIDAINDMGFDASLCD 1554
            +  A + + GMTC SCV+NIE N+  F G+  I VSL + E  V FD  + T E I+  ID+MGF+  VKS   S       ++    +S +K  E  I+ +S  K I+ SLS K   +R+   Q N      H   +     L   +Q             T+ V + V GMTCQSCV NIE  +  K G+  I+V LE+ EA+   D S+     + + INDMGF + +          G   +  + +E  K+ +        + I+ +    CI  IE  +   PGV    V L  +   + +DS     Q + + I  +G+   +  Q       ++R +   S  + + +KC + I GMTC SCV  +E  L   +G+  V V+L   +  + YD A   P  ++ R+ ++G++    A  I      I    + I+GMTC+SCV  I+  IS+  G+ SI VSL   +G ++Y      P+ + DAI+DMGFDA + D
Sbjct:    2 MSEAVISIQGMTCQSCVKNIEVNMAAFPGISTIEVSLENQEGVVSFDPTVTTAEKIAEGIDDMGFEAKVKSPGSSPQEVTIYIEGMTCQSCVKNIEGAISMRSGVKQIKVSLSQKQASIRYDPSQTNPRTLREHIDDMGFEAFLEKPKQ-------------TVNVKIGVEGMTCQSCVKNIEGNMSSKPGVRHIQVSLERKEANITYDPSVVTAQMLRDQINDMGFEATL-------PSNGSSTSFDEFHELAKTRSHADFGKCRLHIEGMTCQSCIKNIEGVIGEFPGVKTIKVTLETKSADVTFDSSIVTAQAVADRISDMGFDCNVADQQDEFDEIASRSAPTKSPPDGTLAKCMVDIEGMTCMSCVKNIEGTLSDEKGIAQVSVSLEEKRGTVQYDPALWSPTTVAERISDMGYDSVVHAAAIPKVPSTISTTVISIKGMTCNSCVKTIQEVISEKPGVRSIKVSLQEEQGVIQYDPDVTSPQQLRDAIDDMGFDACITD 486          

Query:  109 RMKVDGMTCMSCVRNIEENLMKFTGVCGIMVSLLHAEATVIFDADIATVEDISNKIDEMGFDVTVKSSEVSNVKDKVVRSRIKFESDINKSVEKSIETSLSSKLLLVRFCQENNYADIWHYSSIRSTEILSVIQQSEIYGVLVLEQCPTIRVIVRVNGMTCQSCVDNIESTVGKKQGIISIKVFLEKSEAHALVDASL----AGPDVEEMINDMGFNSEMILEIFNDSCAGKPNNVSQKYEELKSNTIYPILSTT-IVIKALKSIFCIFKIENHMRALPGVDKCSVNLIEEIGMIDYDSGKWNVQKIREEIESLGYLTELPKQN----------WNSTRQSSAVSLNEE--------------SRSKCYLRITGMTCSSCVNKVESHLLKVEGVKSVLVALLAMKCEIIYDSAYVMPFQLSNRVKELGFNAEVIENGNEGIGIVNVLIRGMTCSSCVNHIENHISKIKGIASINVSLSTSKGKVEYFISECGPRDVIDAINDMGFDASLCDHLESNHAAADHINQMIKQWRSSFFFSLICGIPXXXXXXXXXXXXXXXXHTII---HENGS--NRTIMKSTVPM---VCSGLSADNLILFVLATPVQFYGARYFYIQAYLSLKHKTTNMDVLVVMATXXXXXXXXXXXXXXMAFRRNTSPKTFFETSPMLIVFLSLGRWLEHIAKGKTSEALTKLMSLQAVEATLYTPEN------KERKIPINLVQRNDLIKILPGEKIPVDGKVVTGTSTCDESLITGESMPIEKTHGSDVIGGSINKSGMLIVKATHVGSDSALAQIVKLVEEAQTSKAPIQQLADRIAGMFVPSVLICAIITLIIWVIVGFSKPEI----LPKYVNELSVTEITWEHAFQLAITVLSIACPCSLGLXXXXXXXXXXXXXXXNGILIKGGEPLENIHKLNVIVFDKTGTITNGSPSVTRFLVLIGNGVREHIDKLLKILAAAESASEHPIGKAIITFSKARISNENLPEVLESSAVSGCGLGCKL----NL----DPKTEVTKFVKNLINIESPSEETNILGQXXXXXXXXXXXXTYKDVIFPVRQHMAWTSDLCQTVTVIIGNRNWMLRNGILVDDEVDELMSEDENLGRTVILMAIDNELIAMISVADQVKREAALAVYTLKKMNIEVYLMTGDNSKTATAIARQVGIHYVFAEVLPSHKVAKVQQLQNTNRSLTSKRKMKVAMVGDGINDSPALAQSDVGIAIGTGTDVAVEAADVVLIRNSLLDVIAAIQLSKATVKRIRQNFIAATLYNLLGIPIAAGVLMPIGIEMMPWMXXXXXXXXXXXXXXXXXXXXXWKKPSEEKL 3930
            +M++DGM C+SC   IE  + K  GV  I V L   EATV++   + TVEDI N+I   GF  +VKS                          K  +  LSS   L+   Q ++       +S ++ E  +    +                ++ V+GM C SCV NI+  +GK +G+ S++V LEK +A    + S+    A     E +    F +++     +   A  P+++S+    L   +  P+ ST  I I+ +    C+  IE  +    GV    V+L    G  ++D      +++R  IE +G+   LP+ N            S+  S A+S  +E              + SKC+++I GMTC+SCV  +E +L    G+ SVLVAL+A K E+ Y+ A + P +++  ++ELGF A V+EN +   G + ++IRGMTC+SCV+ IE+ + K KGI   +V+L+T+K  V+Y     GPRD+I  I ++GF+A L     S  +  DH  + I+QW+ SF  SL+  +P M +M++ M       H I+   H N +  +R +  S + +   +  GLS  NL+ F+   PVQF G R+FY QAY +LKH + NMDVL+V+ATSI++ YS+++++++M  +   +P TFF+T PML VF+SLGRWLE IAK KTSEAL+KLMSLQA EAT+ T          E ++ + LVQR D++K++PG K PVDG+V+ G S  DESLITGE+MP+ K  GS VI GSIN++G L+++ATHVG+D+ L+QIVKLVEEAQTSKAPIQQ ADRI+G FVP ++  +++TL+ W+ +GF    +     P Y   +S  E     AFQ +ITVL IACPCSLGLATPTAVMVGTGVGA NGILIKGGEPLE  H++  +VFDKTGTIT G+P V +  +L+  G R    KLL I+  AE+ SEHP+G AI  F K  +  E L    +  AV GCG+ C +    NL    D   E  +    L+ I  P   +N                 +  ++ P    +  ++    + TV+IGNR WM RN + +  +VDE M+E E  GRT +L+A+D EL AM+++AD VK EA LAV+TL  M +EV LMTGDNSKTA AIA QVGI  VFAEVLPSHKVAKV+QLQ   +        +VAMVGDG+NDSPALA +DVGIAIGTGTDVA+EAADVVLIRN LLDV+A+I LSK TVKRIR NF+ A +YNL+GIPIAAGV MPIG+ + PWM SAAMAASSVSVV  SLLLK + KPS EKL
Sbjct:  171 KMRIDGMVCLSCTTTIEGKIGKLKGVEKIKVGLESQEATVLYLPYLITVEDIVNQIGVAGFKASVKS--------------------------KPRQLQLSSVERLLNASQLSSPTSPEEKTSTQALESTTTTTIT---------------TLINVSGMHCNSCVVNIQDNIGKVRGVSSVQVSLEKRQAVIQHNPSIVTVAALQRAIEALPPGKFKTQL-----DGQDATLPSSLSELS--LLQLSEQPLASTVQIHIEGMTCNSCVQSIEGTISQRKGVRSAQVSLANHQGTFEFDPLLTAPEELRAAIEEMGFDAFLPETNSLIPVKSPPSIRSSPSSPALSTIKEKEKELESDTEAGLNTHSKCFIQIGGMTCASCVANIERNLKNEHGIHSVLVALMASKAEVRYNPAVMDPLKIAECIRELGFTASVMENYDGSDGALELVIRGMTCASCVHKIESSLMKQKGIVYASVALATNKAHVKYDPEVTGPRDIIRLIENLGFEALLVKKDRSG-SHLDHSIE-IQQWKKSFLISLVFCVPVMGMMIYMMVVD----HMIVMSHHHNATREDRQMYHSHMFLERQLLPGLSIMNLLSFLFCVPVQFIGGRHFYAQAYKALKHWSANMDVLIVLATSIAFTYSLVILMVAMIEKAKVNPITFFDTPPMLFVFISLGRWLEQIAKSKTSEALSKLMSLQATEATVVTLNGDTMAVLSEEQVDVELVQRGDIVKVVPGGKFPVDGRVIEGHSMADESLITGEAMPVTKKPGSTVIAGSINQNGSLLIRATHVGTDTTLSQIVKLVEEAQTSKAPIQQFADRISGYFVPFIVAVSVLTLLAWIAIGFVNFRLVEMYFPGYDKSVSQAEAIIRFAFQASITVLCIACPCSLGLATPTAVMVGTGVGAQNGILIKGGEPLEMAHRIQSVVFDKTGTITYGAPKVVQVKILV-EGNRMPRSKLLAIVGTAENNSEHPLGAAITRFCKQELGTEMLGTCTDFQAVPGCGIRCHVSNTENLVKREDSDGEENQRNAILVQISDPRASSN----------------AHPLIMDPEPLTLVQSA----SYTVLIGNREWMRRNALHIRPDVDEAMTEHERRGRTAVLVAVDGELCAMVAIADTVKPEAELAVHTLTSMGLEVVLMTGDNSKTARAIAAQVGIRKVFAEVLPSHKVAKVEQLQQAGK--------RVAMVGDGVNDSPALAMADVGIAIGTGTDVAIEAADVVLIRNDLLDVVASIDLSKKTVKRIRINFVFALIYNLVGIPIAAGVFMPIGLVLQPWMGSAAMAASSVSVVLSSLLLKCYNKPSAEKL 1416          

Query:   97 LGSARMKVDGMTCMSCVRNIEENLMKFTGVCGIMVSLLHAEATVIFDADIATVEDISNKIDEMGFDVTVKSSEVSNVKDKV---VRSRIKFESDINKSVEKSIETSLSSKLLLVRFCQENNYADIWHYSSIRSTEILSVIQQSEIYGVLVLEQCPT-----------IRVI-VRVNGMTCQSCVDNIESTVGKKQGIISIKVFLEKSEAHALVDASLAGPDVEEMINDM---GFNSEM-----------ILEIFNDSCAGKPNNVSQKYEELKSNTIYPILSTTIV-IKALKSIFCIFKIENHMRALPGVDKCSVNLIEEIGMIDYDSGKWNVQKIREEIESL---GYLTELPKQNWN----STRQSSAVSLNEESRSKCYLRITGMTCSSCVNKVESHLLKVEGVKSVLVALLAMKCEIIYDSAYVMPFQLSNRVKELGFNA----------------------------------EVIENGNEGIGIVN---VLIRGMTCSSCVNHIENHISKIKGIASINVSLSTSKGKVEYFISECGPRDVIDAINDMGFDASLCDHLESNHAA 1578
            L S  + V+GMTC SCV+ IE+ +   +GV  I VSL    ATVIFD    + E +++ I++MGF+     S+V+N          +R+   +  +   ++   T L+ +L  V   QE+        + I +  ++S  +  E    LV +   T           + V+ +R++GM C SC   IE  +GK +G+  IKV LE  EA  L    L    VE+++N +   GF + +           +  + N S    P +  +K       +      TT++ +  +    C+  I++++  + GV    V+L +   +I ++     V  ++  IE+L    + T+L  Q+       +  S      +   S   + I GMTC+SCV  +E  + + +GV+S  V+L   +    +D     P +L   ++E+GF+A                                  E+  +   G+   +   + I GMTC+SCV +IE ++    GI S+ V+L  SK +V Y  +   P  + + I ++GF AS+ ++ + +  A
Sbjct:    8 LCSVTLTVEGMTCGSCVQTIEQQIGGLSGVIHIEVSLEQKNATVIFDPASHSPESLADAIEDMGFE-----SDVTNASPTTPVQTETRVYPTTGCSAEAQRQAHTQLA-QLKGVVETQESIEGKGLAVTFIPT--VVSPERVREAVSCLVPQPASTSERSTGRGSGNVEVVKMRIDGMVCLSCTTTIEGKIGKLKGVEKIKVGLESQEATVLYLPYLI--TVEDIVNQIGVAGFKASVKSKPRQLQLSSVERLLNASQLSSPTSPEEKTSTQALESTTTTTITTLINVSGMHCNSCVVNIQDNIGKVRGVSSVQVSLEKRQAVIQHNPSIVTVAALQRAIEALPPGKFKTQLDGQDATLPSSLSELSLLQLSEQPLASTVQIHIEGMTCNSCVQSIEGTISQRKGVRSAQVSLANHQGTFEFDPLLTAPEELRAAIEEMGFDAFLPETNSLIPVKSPPSIRSSPSSPALSTIKEKEKELESDTEAGLNTHSKCFIQIGGMTCASCVANIERNLKNEHGIHSVLVALMASKAEVRYNPAVMDPLKIAECIRELGFTASVMENYDGSDGA 565          

Query:  103 SARMKVDGMTCMSCVRNIEENLMKFTGVCGIMVSLLHAEATVIFDADIATVEDISNKIDEMGFDVTV-KSSEVSNVKDKVVRSRIKFESDIN--KSVEKSIETSLSSKLLLVRFCQENNYADIWHYSSIRSTEILSVIQQSEIYGVLVLEQCPTIRVIVRVNGMTCQSCVDNIESTVGKKQGIISIKVFLEKSEAHALVDASLAGP-DVEEMINDMGFNSEMILEIFNDSCAGKPNNVSQKYEELKSNTIYPILSTTIVIKALKSIFCIFKIENHMRALPGVDKCSVNLIEEIGMIDYDSGKWNVQKIREEIESLGYLTELPKQNWNSTRQSSAVSLNEESRS 1119
            + ++ ++GMTC SCV++IE  + +  GV    VSL + + T  FD  +   E++   I+EMGFD  + +++ +  VK             ++  K  EK +E+   + L        N ++  +                                  +++ GMTC SCV NIE  +  + GI S+ V L  S+A    + ++  P  + E I ++GF +  ++E ++ S                        +  +VI+ +    C+ KIE+ +    G+   SV L      + YD      + I   IE+LG+   L K++ + +    ++ + +  +S
Sbjct:  376 TVQIHIEGMTCNSCVQSIEGTISQRKGVRSAQVSLANHQGTFEFDPLLTAPEELRAAIEEMGFDAFLPETNSLIPVKSPPSIRSSPSSPALSTIKEKEKELESDTEAGL--------NTHSKCF----------------------------------IQIGGMTCASCVANIERNLKNEHGIHSVLVALMASKAEVRYNPAVMDPLKIAECIRELGFTAS-VMENYDGSDG----------------------ALELVIRGMTCASCVHKIESSLMKQKGIVYASVALATNKAHVKYDPEVTGPRDIIRLIENLGFEALLVKKDRSGSHLDHSIEIQQWKKS 653          

Query: 1339 GIGIVNVLIRGMTCSSCVNHIENHISKIKGIASINVSLSTSKGKVEYFISECGPRDVIDAINDMGFDASLCD 1554
            G+  V + + GMTC SCV  IE  I  + G+  I VSL      V +  +   P  + DAI DMGF++ + +
Sbjct:    7 GLCSVTLTVEGMTCGSCVQTIEQQIGGLSGVIHIEVSLEQKNATVIFDPASHSPESLADAIEDMGFESDVTN 78          

Query: 2050 KGKTSEALTKLMSLQAVEATLYTPEN-----KERKIPINLVQRNDLIKILPGEKIPVDGKVVTGTSTCDESLITGESMPIEKTHGSDVIGGSINKSGMLIVKATHVGSDSALAQIVKLVEEAQTSKAPIQQLADRIAGMFVPSVLICAIITLIIWVIVGFSKPEILPKYVNELSVTEITWEHAFQLAITVLSIACPCSLGLXXXXXXXXXXXXXXXNGILIKGGEPLENIHKLNVIVFDKTGTITNGSPSVTRFLVLIGNGVREHIDKLLKILAAAESASEHPIGKAIITFSKARISNENLPEVLESSAVSGCGLGCKLNLDPKTEVTKFVKNLINIESPSEETNILGQXXXXXXXXXXXXTYKDVIFPVRQHMAWTSDLCQTVTVIIGNRNWMLRNGILVDDEVDELMSEDENLGRTVILMAIDNELIAMISVADQVKREAALAVYTLKKMNIEVYLMTGDNSKTATAIARQVGIHYVFAEVLPSHKVAKVQQLQNTNRSLTSKRKMKVAMVGDGINDSPALAQSDVGIAIGTGTDVAVEAADVVLIRNSLLDVIAAIQLSKATVKRIRQNFIAATLYNLLGIPIAAGVLMPIGIEMMPWM 3840
            + KTSEAL KLMSLQAV+AT+ T  +      E ++ + LVQR D++K+ PG K PVDGKV+ G+S  DESLITGE MP+ K  GS VI GSIN  G L+V+ATHVG+D+ L+QIV+LVEEAQTSKAPIQQLAD+++G FVP +++ ++ TL                Y   +  T++    AFQ +ITVLSIACPCSLGLATPTAVMVGTGVGA NGILIKGGEPLE  HK+  ++FDKTGTITNG P VTR LVL  +  R  + K+L ++  AE++SEHP+G      S   + +E L    +  AV GCG+ CK+     + + + ++N    E P                                          T +V+IGNR WM RN I V  +VDE MS  E  G+T IL+AID  L AM+++AD VK E+ALAV+TL +M I+V ++TGDN +TA AIA QVGI  VFAEVLPSHKVAKVQ+LQ         + +KVAMVGDG+NDSPALA++D+GIAIGTGTDVA+EAADVVLIRN LLDV+A+I+LSK TV+RIR NF+ A +YNLLGIPIAAGV MP+G+ + PWM
Sbjct:  647 QSKTSEALAKLMSLQAVDATIVTLGHDNSIISEEQVSVQLVQRGDVVKVAPGGKFPVDGKVIEGSSMADESLITGEPMPVRKKPGSCVIAGSINAHGALLVEATHVGADTTLSQIVRLVEEAQTSKAPIQQLADKLSGYFVPFIVVVSVATL---------------GYDTNIPRTDVIVRFAFQASITVLSIACPCSLGLATPTAVMVGTGVGAQNGILIKGGEPLEMAHKIKAVMFDKTGTITNGVPRVTRVLVLW-DQARLPLRKVLAVVGTAEASSEHPLGNG----SCQTLQSELLGHCHDFQAVPGCGISCKV-----SNIEELLQNSSEAEGPP-----------------------------------------TYSVLIGNRQWMQRNAIQVTADVDEAMSSHETKGQTAILVAIDGVLCAMLAIADTVKEESALAVHTLSRMGIDVLMITGDNRRTAKAIATQVGIRKVFAEVLPSHKVAKVQELQ--------AKGLKVAMVGDGVNDSPALARADLGIAIGTGTDVAIEAADVVLIRNDLLDVVASIELSKKTVQRIRINFMFALIYNLLGIPIAAGVFMPVGLVLQPWM 1174          

Query:   88 RMKLGSARMKVDGMTCMSCVRNIEENLMKFTGVCGIMVSLLHAEATVIFDADIATVEDISNKIDEMGFDVTVKSSEVSNVKDKV-------VRSRIKFESDINKSVEKSIETSLSSKLLL--VRFCQENNYADIWHYSSIRSTEILSVIQQSEIYG--VLVLEQCPTI-------------------RVIVRVNGMTCQSCVDNIESTVGKKQGIISIKVFLEKSEAHALVDASL-AGPDVEEMINDMGFNSEMILEIFNDSCAGKPNNVSQKYEELKSNTIYPILSTTIVIKALKSIFCIFKIENHMRALPGVDKCSVNLIEEIGMIDYDSGKWNVQKIREEIESLGYLTELPKQNWNSTRQSSAVSLNEESRSKCYLRITGMTCSSCVNKVESHLLKVEGV--KSVLVALLAMKCEIIYDSAYVMPFQLSNRVKELGFNAEVIENGNEGIGIVNVLIRGMTCSSCVNHIENHISKIKGIASINVSLSTSKGKVEYFISECGPRDVIDAINDMGFDASL--CDHLESNHAAADHINQMIKQWRSSFFFSLICGIPXXXXXXXXXXXXXXXXHTIIHENGSNRTIMKSTVPMVCSGLSADNLILFVLATPVQ 1818
            R++    R+ V+GMTC SCVR IE  +    GV GI VSL   EA + F+ +    +++   I+EMGF+  VK   V ++  +        +  R+  E     S  K+I  +LS  L +  V    E+   D+ +  S+ + + +  + +S   G   + L +  +                    +V + + GMTC SCV +IE  + +K G+ SI V+L++ +     D+SL    ++ + I DMGF + +                  K   + S+T +             SIFC+  +  +                          K  + ++  +++S      LP   W    Q S + L    +  C++ +TGMTC+SCV+ +E  LLK +GV  KSVLVAL+A K EI YD   + P Q+   +  LGF A ++E G    G++++ + GMTC+SCV++IE+ + + KGI    VSL+TSK  V++     G RD+I  +  +GF ASL   D L  N+       + I+QW+ SF  SL+CGIP   + +         +H+   E+G +    ++ +P    GLS  NL+ F+L TPVQ
Sbjct:  115 RLEESLVRISVEGMTCHSCVRTIEGRIGALQGVLGIQVSLSEKEAVIWFNNETVKPDELRKHIEEMGFEAFVKDPLVPHLATQAGPHTPDWLEVRLGVEGMHCGSCVKNITENLSGMLGVQSVLVYLESKTLDLKYDPSLVTLDTVKGVLESLPPGNFKVTLPESGSFHKPRTNGSIRSQNSVESLQKVTIGIKGMTCNSCVQSIEGLISQKHGVHSITVYLKEEKGVITFDSSLTTSTELRDAIEDMGFEAFL------------------KQGRVCSHTFFSY-----------SIFCLLILSVYF-------------------------KKEMDRLNSKVDS-----NLP---W----QRSILHLAPFQK--CFVCVTGMTCASCVSNIERTLLKHKGVWIKSVLVALMAGKAEIKYDPEDLDPAQIVKLISGLGFGASLVEEGAINDGVLDLSVTGMTCASCVHNIESKLCRSKGILEATVSLATSKAHVKFDPDVVGVRDIIRIVEGLGFGASLIKSDDLRKNNDLGHQ--EEIRQWKHSFLISLVCGIP--VMGLMIYMMVMDSQHS---EHGGSMPEEQNILP----GLSLLNLVFFLLCTPVQ 647          

Query:  559 RVIVRVNGMTCQSCVDNIESTVGKKQGIISIKVFLEKSEAHALVD---ASLAGPDVEEMINDMGFNSEMILEIFNDSCAGKPNNVSQKYEELKSNTIYPILSTTIVIKALKSIFCIFKIENHMRALPGVDKCSVNLIEEIGMIDYDSGKWNVQKIREEIESLGY--LTELPKQNWNSTRQSSAVSLNEESRSKCYLRITGMTCSSCVNKVESHLLKVEGVKSVLVALLAMKCEIIYDSAYVM------------PFQLSNRVKELGFNAEVIENGN-------EGIGIVNVLIRGMTCSSCVNHIENHISKIKGIASINVSLSTSKGKVEYFISECGPRDVIDAINDMGFDASL-----CDH 1557
            R+ + ++G T   CV  ++S +    G+ ++ V  +     A +D   +++   ++ + I  MG+    + E+ N   AG       + EE             I ++ +    C+  IE  + AL GV    V+L E+  +I +++      ++R+ IE +G+    + P     +T+         E R    L + GM C SCV  +  +L  + GV+SVLV L +   ++ YD + V             P      + E G   +   NG+       E +  V + I+GMTC+SCV  IE  IS+  G+ SI V L   KG + +  S     ++ DAI DMGF+A L     C H
Sbjct:   35 RLSLLISGPTSPDCVQGLQSWLSALSGVTAVSV-PQSGSGLAWIDFHPSTVTTREILQEIQGMGYG---VNEVSN---AGVSQPALPRLEESL---------VRISVEGMTCHSCVRTIEGRIGALQGVLGIQVSLSEKEAVIWFNNETVKPDELRKHIEEMGFEAFVKDPLVPHLATQAGPHTPDWLEVR----LGVEGMHCGSCVKNITENLSGMLGVQSVLVYLESKTLDLKYDPSLVTLDTVKGVLESLPPGNFKVTLPESGSFHKPRTNGSIRSQNSVESLQKVTIGIKGMTCNSCVQSIEGLISQKHGVHSITVYLKEEKGVITFDSSLTTSTELRDAIEDMGFEAFLKQGRVCSH 376          

Query: 1051 LPKQNWNSTRQS-----------SAVSLNEESRSKCYLRITGMTCSSCVNKVESHLLKVEGVKSVLVALLAMKCEII-YDSAYVMPFQLSNRVKELGFNAEVIENGNEGIG----------IVNVLIRGMTCSSCVNHIENHISKIKGIASINVSLSTSKGKVEYFISECGPRDVIDAINDMGFDASLCDHL 1560
            +P + W S +             S +  N    S+  L I+G T   CV  ++S L  + GV +V V         I +  + V   ++   ++ +G+   V E  N G+           +V + + GMTC SCV  IE  I  ++G+  I VSLS  +  + +      P ++   I +MGF+A + D L
Sbjct:    1 VPSEAWASKKHGFNNLAYEPGSLSDLRPNSGHPSRLSLLISGPTSPDCVQGLQSWLSALSGVTAVSVPQSGSGLAWIDFHPSTVTTREILQEIQGMGYG--VNEVSNAGVSQPALPRLEESLVRISVEGMTCHSCVRTIEGRIGALQGVLGIQVSLSEKEAVIWFNNETVKPDELRKHIEEMGFEAFVKDPL 190          

Query: 3307 DNELIAMISVADQVKREAALAVYTLKKMNIEVYLMTGDNSKTATAIARQVGIH-------------------------------YVFAEVLPSHKVAKVQQLQNTNRSLTSKRKMKVAMVGDGINDSPALAQSDVGIAIGTGTDVAVEAADVVLIRNSLLDVIAAIQLSKATVKRIRQ 3747
            D   +  + + D  + E A ++   ++  I V ++TGDN  TA AI R++GI                                  FA V PSHK   V+ LQ  +           AM GDG+ND+PAL ++++GIA+G+GT VA  A+++VL  ++   ++AA++  +A    ++Q
Sbjct:  582 DLTFVGCVGMLDPPRTEVAASIKLCRQAGIRVIMITGDNKGTAVAICRRIGIFSEEDDVHRMAFTGREFDDLSPHSQREAVTNARCFARVEPSHKSKIVEFLQGFDEI--------TAMTGDGVNDAPALKKAEIGIAMGSGTAVAKTASEMVLADDNFSSIVAAVEEGRAIYNNMKQ 751          

Query: 3307 DNELIAMISVADQVKREAALAVYTLKKMNIEVYLMTGDNSKTATAIARQVGIH-------------------------------YVFAEVLPSHKVAKVQQLQNTNRSLTSKRKMKVAMVGDGINDSPALAQSDVGIAIGTGTDVAVEAADVVLIRNSLLDVIAAIQLSKATVKRIRQ 3747
            D   +  + + D  + E A ++   +   I V ++TGDN  TA AI R++GI                                  FA V PSHK   V+ LQ+ +           AM GDG+ND+PAL ++++GIA+G+GT VA  A+++VL  ++   ++AA++  +A    ++Q
Sbjct:  588 DLTFVGCVGMLDPPRAEVAASMKLCRLAGIRVIMITGDNKGTAVAICRRIGIFGENDDVSSMAFTGREFDDLSPATQREAVLTARCFARVEPSHKSKIVEYLQSYDEI--------TAMTGDGVNDAPALKKAEIGIAMGSGTAVAKTASEMVLADDNFATIVAAVEEGRAIYNNMKQ 757          

Query: 3307 DNELIAMISVADQVKREAALAVYTLKKMNIEVYLMTGDNSKTATAIARQVGIH-------------------------------YVFAEVLPSHKVAKVQQLQNTNRSLTSKRKMKVAMVGDGINDSPALAQSDVGIAIGTGTDVAVEAADVVLIRNSLLDVIAAIQLSKATVKRIRQ 3747
            D   +  + + D  + E A ++   +   I V ++TGDN  TA AI R++GI                                  FA V PSHK   V+ LQ+ +           AM GDG+ND+PAL ++++GIA+G+GT VA  A+++VL  ++   ++AA++  +A    ++Q
Sbjct:  582 DLTFVGCVGMLDPPRAEVAASMKLCRLAGIRVIMITGDNKGTAVAICRRIGIFGENDDVSSMAFTGREFDDLSPATQREAVLTARCFARVEPSHKSKIVEYLQSYDEI--------TAMTGDGVNDAPALKKAEIGIAMGSGTAVAKTASEMVLADDNFATIVAAVEEGRAIYNNMKQ 751          

Query: 1528 MGFDASLCDHLESNHAAADHINQMIKQWRSSFFFSLICGIPXXXXXXXXXXXXXXXXHTIIHENGSNRTIMKSTVPMVCSGLSADNLILFVLATPVQFYGARYFYIQAYLSLKHKTTNMDVLVVMATXXXXXXXXXXXXXXMAFRRNTSPKTFFETSPMLIVFLSLGRWLEHIAKGKTSEALTKLMSLQAVEATLYT--PENK---ERKIPINLVQRNDLIKILPGEKIPVDGKVVTGTSTCDESLITGESMPIEKTHGSDVIGGSINKSGMLIVKATHVGSDSALAQIVKLVEEAQTSKAPIQQLADRIAGMFVPSVLICAIITLIIWVIVGFSKPEILPKYVNELSVT----EITWEHAFQLAITVLSIACPCSLGLXXXXXXXXXXXXXXXNGILIKGGEPLENIHKLNVIVFDKTGTITNGSPSVTRFLVLIGNGVREHIDKLLKILAAAESASEHPIGKAIITFSKARISNENLPEVLESSAVSGCGLGCKL-NLDPKTEVTKFVKNLINIESPSEETNILGQXXXXXXXXXXXXTYKDVIFPVRQHMAWTSDLCQTVTVIIGNRNWMLRNGILVDDEVDELMSEDENLGRTVILMAIDNELIAMISVADQVKREAALAVYTLKKMNIEVYLMTGDNSKTATAIARQVGIHYVFAEVLPSHKVAKVQQLQNTNRSLTSKRKMKVAMVGDGINDSPALAQSDVGIAIGTGTDVAVEAADVVLIRNSLLDVIAAIQLSKATVKRIRQNFIAATLYNLLGIPI 3792
            MG+ A+L        +  +H ++ I+QWR++F  +L+ GIP M +M++ +      KH  +  +            MV  GLS  NL+ F L TPVQF G R+FY +AY S+K++  NMDVL+V+ATSI+Y+YSV++++++MA R   SP TFF+T PML VF++LGRWLEH+AKGKTSEAL KLMSLQA EATL T  P+N    E ++ + L+QR D ++++PG + PVDG+V+ GTS  DES+ITGE MP+ K  GS VI GSIN+ G L+V+ATHVG+D+ LAQIV+LVEEAQTSKAPIQQLADR++G FVP+V++ + +TL+ W++VGF+   ++ KY  +   +    E+    AFQ AITVLSIACPC+LGLATPTAVMVGTGVGA NGILIKGGEPLE  HK+  +VFDKTGT+T+G P V RF  L GN  R    +L  I+  AE++SEHP+G AI    K  +S E L       AV G G+ C++ N+D         +      SPS   N                +   +I    +  A   +L Q   V+IGNR WM R+G+ V   V   M++ E  G T +L+A+D +L  M+++AD VK EAAL V TL  M + V L+TGDN +TA AIA QVG+   +AEVLP+ KV +V++LQ        ++ ++VAMVGDG+NDSPALAQ+DVGIAIG+GTDVA+ AAD+VLIR++LLDV+++I+LSK TV RIR NFI A +YNLLG+PI
Sbjct:    3 MGYTAALVKQECRGTSHLEHTDE-IRQWRNAFLLNLLFGIPVMALMVYMIVMDSQKKHNYLMNH------------MVLPGLSTINLVFFALCTPVQFVGGRHFYARAYKSVKYRAANMDVLIVLATSIAYVYSVVILLVAMAERAPRSPLTFFDTPPMLFVFITLGRWLEHLAKGKTSEALAKLMSLQAAEATLVTLGPDNSLVSEEQVEVELLQRGDALRVVPGARFPVDGRVIAGTSMADESIITGEVMPVSKGPGSLVIAGSINQMGSLLVEATHVGADTTLAQIVRLVEEAQTSKAPIQQLADRLSGYFVPTVVLLSTLTLVTWIVVGFADFAVVQKYFPDFDPSLPHGEVVLRFAFQAAITVLSIACPCALGLATPTAVMVGTGVGAQNGILIKGGEPLEMAHKIKAVVFDKTGTLTHGMPRVLRF-ALFGNRARVSPRRLTAIVGTAEASSEHPLGVAITKHCKQELSTERLGSCQAFQAVPGFGISCEVSNVDAALNAVDEDEENEKNASPSAPAN---------------RSAPHIIMDGDESTATRHEL-QRYAVLIGNREWMGRSGVEVAPAVHAAMAQHEEQGHTAVLVAVDGQLCGMLAIADAVKEEAALVVRTLTAMGLHVILLTGDNRRTARAIAAQVGVRTAYAEVLPADKVREVERLQ--------RQGLRVAMVGDGVNDSPALAQADVGIAIGSGTDVAIAAADIVLIRSNLLDVVSSIELSKKTVLRIRINFIFALVYNLLGLPI 729          

Query: 3301 AIDNELIAMISVADQVKREAALAVYTLKKMNIEVYLMTGDNSKTATAIARQVGIHYVFAEVLPSHKVAKVQQLQNTNRSLTSKRKMKVAMVGDGINDSPALAQSDVGIAIGTGTDVAVEAADVVLIRNSLLDVIAAIQLSKATVKRIRQNFIAATLYNLLGIPIAAG 3801
            A   +L  M+++AD VK EAALAV TL  M ++V LMTGDN KTA AIA QVGI  VFAEVLPSHKVAKV+QLQ + ++        VAMVGDG+NDSPALA+SDVGIA+GTGTDVA+EAAD+VLIRN LLDV+A+I LSK TV+RI  NF+ A +YN++GIPIAAG
Sbjct:    1 ACSGKLCGMLAIADTVKPEAALAVRTLADMGLQVVLMTGDNRKTAQAIAAQVGIRRVFAEVLPSHKVAKVEQLQESGQT--------VAMVGDGVNDSPALARSDVGIALGTGTDVAIEAADIVLIRNDLLDVVASIHLSKKTVRRIHINFVFALIYNVVGIPIAAG 159          

Query:  796 NNVSQKYEE------LKSNTIYPILSTTIV-IKALKSIFCIFKIENHMRALPGVDKCSVNLIEEIGMIDYDSGKWNVQKIREEIESLGYLTELPKQNWNSTR--------QSSAVSLNEESRSKCYLRITGMTCSSCVNKVESHLLKVEGVKSVLVALLAMKCEIIYDSAYVMPFQLSNRVKEL---------GFNAEVIENGN---------------EGIGIVN---VLIR--GMTCSSCVNHIENHISKIKGIASINVSLSTSKGKVEYFISECGPRDVIDAINDMGFDASLCDHL 1560
            N + QK E+      L++    P L+T +V ++ +K   C  ++E+ +  LPGV+    +L      I Y S   N  ++R +IE+LG+   LPK      +        QSSA        +   L + GM C SCV+ +ESH+ ++  V S+ V+L   K +I Y+   + P  L   ++ L         G  +  + + N               E +   +   V++R  GMTC+SCV ++E  ++K  G+ S++VSL      V Y      P  +  A+ DMG+ A+L  ++
Sbjct:  112 NVICQKIEDFGYRATLQAGRRQPGLATLVVTVEGMKRQTCARRVESALAKLPGVEHVEASLASREVRIGYKSHLINASELRRQIEALGFAALLPKSPLKREKSRALPADPQSSAPPSEAIESATITLGVEGMHCKSCVDNIESHVGELAAVYSIEVSLSESKADIRYNPTLLGPADLKQAIESLPPGNLSVSFGLRSTDLPSPNVYQSLLSRCAKGAVEEPVPRADNPTVVLRVTGMTCASCVQNVEGGLAKRAGVRSVSVSLGDGTATVSYDRGVTSPEILQGAVEDMGYGATLTGNI 410          

Query:  562 VIVRVNGMTCQSCVDNIESTVGKKQGIISIKVFLEKSEAH-----ALVDASLAGPDVEEMINDMGFNSEMILEIF----NDSCAGKPNNVSQKYEELKSNTIYPILSTTIVIKALKSIFCIFKIENHMRALPGVDKCSVNLIEEIGMIDYDSGKWNVQKIREEIESL--GYL--------TELPKQN-WNSTRQSSAVSLNEESRSKC-----YLRITGMTCSSCVNKVESHLLKVEGVKSVLVALLAMKCEIIYDSAYVMPFQLSNRVKELGFNAEVIENGNEGIGIVNV---------------------------------LIR--GMTCSSCVNHIENHISKIKG 1428
            ++V V GM  Q+C   +ES + K  G+  ++  L   E        L++AS    ++   I  +GF + +         + +    P + +   E ++S TI      T+ ++ +    C+  IE+H+  L  V    V+L E    I Y+        +++ IESL  G L        T+LP  N + S     A    EE   +       LR+TGMTC+SCV  VE  L K  GV+SV V+L      + YD     P  L   V+++G+ A +   GN  + +  V                                 L+R  GMTC+SCV +IEN++ K  G
Sbjct:  139 LVVTVEGMKRQTCARRVESALAKLPGVEHVEASLASREVRIGYKSHLINAS----ELRRQIEALGFAALLPKSPLKREKSRALPADPQSSAPPSEAIESATI------TLGVEGMHCKSCVDNIESHVGELAAVYSIEVSLSESKADIRYNPTLLGPADLKQAIESLPPGNLSVSFGLRSTDLPSPNVYQSLLSRCAKGAVEEPVPRADNPTVVLRVTGMTCASCVQNVEGGLAKRAGVRSVSVSLGDGTATVSYDRGVTSPEILQGAVEDMGYGATL--TGNIPLSLSPVTFPPSLTVNLDLYVELPPKPSGEREDAREPEKCLLRVTGMTCASCVANIENNLKKKDG 475          

Query:  112 MKVDGMTCMSCVRNIEENLMKFTGVCGIMVSLLHAEATVIFDADIATVEDISNKIDEMGFDVTVKSSEVSNVKDKVVRSRIKFESDINKSVEKSIETSLSSKLLLVRFCQENNYADIWHYSSIRSTEILSVIQQSEIYGVLVLEQCPTIRVIVRVNGMTCQSCVDNIESTVGKKQG 639
            ++V GMTC SCV+N+E  L K  GV  + VSL    ATV +D  + + E +   +++MG+  T+      N+   +  S + F   +  +++  +E                                L      E       E+C     ++RV GMTC SCV NIE+ + KK G
Sbjct:  343 LRVTGMTCASCVQNVEGGLAKRAGVRSVSVSLGDGTATVSYDRGVTSPEILQGAVEDMGYGATL----TGNIPLSL--SPVTFPPSLTVNLDLYVE--------------------------------LPPKPSGEREDAREPEKC-----LLRVTGMTCASCVANIENNLKKKDG 475          

Query: 3304 IDNELIAMISVA--DQVKREAALAVYTLKKMNIEVYLMTGDNSKTATAIARQVGIH-------------------------------YVFAEVLPSHKVAKVQQLQNTNRSLTSKRKMKVAMVGDGINDSPALAQSDVGIAIGTGTDVAVEAADVVLIRNSLLDVIAAIQLSKATVKRIRQ 3747
            +D   +  + V   D  ++E + ++   ++  I V    GDN  TA AI R++GI                                  FA V PSHK   V+ LQ+ +           AM GDG+ND+PAL ++++GIA+G+GT VA  A+++VL  ++   ++AA++  +A    ++Q
Sbjct:  437 VDLTFVGCVGVGMLDPPRKEVSSSIILCREAGIRV---IGDNKGTAVAICRRIGIFGEDEDVKDKAYTGREFDDLPLEEQRLACQRARCFARVEPSHKSKIVEFLQSCDEI--------TAMTGDGVNDAPALKKAEIGIAMGSGTAVAKSASEMVLADDNFSSIVAAVEEGRAIYNNMKQ 606          

Query: 3280 GRTVILMAIDNEL-----IAMISVADQVKREAALAVYTLKKMNIEVYLMTGDNSKTATAIARQVGIHY----------------------------VFAEVLPSHKVAKVQQLQNTNRSLTSKRKMKVAMVGDGINDSPALAQSDVGIAIG-TGTDVAVEAADVVLIRNSLLDVIAAIQLSKATVKRIRQNFI 3756
            G  V+ MA   EL     + ++ + D  +     +V  L    + V ++TGD+ +TA AIA ++G+                              VF    P HK+  V+ LQ        K    V M GDG+ND+ AL  +D+G+A+G +GTDV  EAAD++L+ +    +++AI+  K     I+ NF+
Sbjct:   40 GLRVLAMASGPELGQLTFLGLVGIIDPPRPGVRKSVAILVSSGVSVKMVTGDSMETAVAIANRLGLSSNGGGAAISGEEAWGGRHPAAAFVVLQVSVFYRASPRHKLKIVKALQ--------KNGEVVGMTGDGVNDAVALRAADIGVAMGRSGTDVCKEAADMILVDDDFYTIMSAIEEGKGIFYNIK-NFV 223          

Query:  892 CIFKIENHMRALPGVDKCSVNLIEEIGMIDYDSGKWNVQKIREEIESLGYLTELPKQNWNSTRQSSAVSLNEESRSKCYLRITGMTCSSCVNKVESHLLKVEGVKSVLVALLAMKCEIIYDSAYVMPFQLSNRVKELGFNAEVIENGNEGIGIVNVLIRGMTCSSCVNHIENHISKIK---------GIASINVSLSTSKGKVEYFISECGPRDVIDAINDMGFDASLCDHLESNH-----AAADHINQMIKQWRSSFFFSLICGIPXXXXXXXXXXXXXXXXHTIIHENGSNRTIMKSTVPMVCSGLSADNLILFVLATPVQFYGARYFYIQAYLSLKHKTTNMDVLVVMATXXXXXXXXXXXXXXMAFRRNTS--PKTFFETSPMLIVFLSLGRWLEHIAKGKTSEALTKLMSLQAVEATLYT--PENKERKIPINLVQRNDLIKILPGEKIPVDGKVVTGTSTCDESLITGESMPIEKTHGSDVIGGSINKSGMLIVKATHVGSDSALAQIVKLVEEAQTSKAPIQQLADRIAGMFVPSVLICAIITLIIW-VIVGFSKPEILPKYVNELSVTEITWEHAFQLAITVLSIACPCSLGLXXXXXXXXXXXXXXXNGILIKGGEPLENIHKLNVIVFDKTGTITNGSPSVTRFLV---LIGNGVREHIDKLLKILAAAESASEHPIGKAIITFSKARISNENLPE-VLESSAVSGCGLGCKLNLDPKTEVTKFVKNLINIESPSEETNILGQXXXXXXXXXXXXTYKDVIFPVRQHMAWTSDLCQTVTVIIGNRNWMLRNGI----LVDDEVDELMSEDENLGRTVILMAIDNELIAMISVADQVKREAALAVYTLKKMNIEVYLMTGDNSKTATAIARQVGIHY--VFAEVLPSHKVAKVQQLQNTNRSLTSKRKMKVAMVGDGINDSPALAQSDVGIAIGTGTDVAVEAADVVLI------RNSLLDVIAAIQLSKATVKRIRQNFIAATLYNLLGIPIAAGVLMPIGIEMMPWM 3840
            C   I   +RAL GV KC ++L+     + YD+ +     I+E IE  G+  E+ + +     + +A+S  E       L + GMTC SCV+ V   +  +EGV+SV+V+L+  +C +IY+ +          +++ GF++ +I +GN    +    +      +  +     +S +          G+ SI +S       ++Y  +E G RD++  +   G+  ++  +L++       +  D I    K    S   ++IC +              M+  TI+ +      I          GL   +++  +LA+ +QF    YFY  A+ SLKH +  MD LV ++T+ +Y +SV  +V +M    +T   P+  F+TS M+I ++S+G++LE +AK +TS AL+KL+ L     ++ +    N+ ++IPI L+Q ND+++I PG KIP DG +  G S  DESL+TGES+ + K  G  VI GS+N  G    + T VG ++ LA I+K+++EAQ SKAPIQ  AD +A +FVP +LI A++T  IW  I+  S     P      +     +    Q A +V+ +ACPC+LGLATPTA+MVGTGVGA NG+LIKGGE LE  + +   VFDKTGT+T G   V +FL     +GN V E  D++L  + A ES S+HP+ KAII +      N+ L   VLES  V G G+  K  ++  T                                                     D+C      IGN   +L + +     ++  VD+        G TV  ++++  +  +  + D+VK ++   V  L++   E Y++TGDN+  A  +AR+VGI +  V+++V P+ K   V+++Q+       +   KVA+VGDGIND+PALA SD+GIAI TGT++A+EAAD+V++       NSL  +  AI +S  T KRI+ N   A  YN+  IPIA GVL+P GI + P +
Sbjct:   16 CTNTINTQLRALKGVTKCDISLVTNECQVTYDN-EVTADSIKEIIEDCGFDCEILRDS-----EITAISTKEG-----LLSVQGMTCGSCVSTVTKQVEGIEGVESVVVSLVTEECHVIYEPSKTTLETAREMIEDCGFDSNIIMDGNGNADMTEKTVILKVTKAFEDESPLILSSVSERFQFLLDLGVKSIEISDDMHTLTIKYCCNELGIRDLLRHLERTGYKFTVFSNLDNTTQLRLLSKEDEIRFWKKNSIKSTLLAIICML--------LYMIVPMMWPTIVQDR-----IFPYKETSFVRGLFYRDILGVILASYIQFSVGFYFYKAAWASLKHGSGTMDTLVCVSTTCAYTFSVFSLVHNMFHPSSTGKLPRIVFDTSIMIISYISIGKYLETLAKSQTSTALSKLIQLTPSVCSIISDVERNETKEIPIELLQVNDIVEIKPGMKIPADGIITRGESEIDESLMTGESILVPKKTGFPVIAGSVNGPGHFYFRTTTVGEETKLANIIKVMKEAQLSKAPIQGYADYLASIFVPGILILAVLTFFIWCFILNISAN---PPVAFTANTKADNFFICLQTATSVVIVACPCALGLATPTAIMVGTGVGAQNGVLIKGGEVLEKFNSITTFVFDKTGTLTTGFMVVKKFLKDSNWVGN-VDE--DEVLACIKATESISDHPVSKAIIRYCDGLNCNKALNAVVLESEYVLGKGIVSKCQVNGNT----------------------------------------------------YDIC------IGNEALILEDALKKSGFINSNVDQ--------GNTVSYVSVNGHVFGLFEINDEVKHDSYATVQYLQRNGYETYMITGDNNSAAKRVAREVGISFENVYSDVSPTGKCDLVKKIQD------KEGNNKVAVVGDGINDAPALALSDLGIAISTGTEIAIEAADIVILCGNDLNTNSLRGLANAIDISLKTFKRIKLNLFWALCYNIFMIPIAMGVLIPWGITLPPML 931          

Query: 1129 LRITGMTCSSCVNKVESHLLKVEGVKSVLVALLAMKCEIIYDSAYVMPFQLSNRVKELGFNAEVIENG-------NEGIGIVNVLIRGMTCSSCVNHIENHISKIKGIASINVSLSTSKGKVEYFISECGPRDVIDAINDMGFDASL 1548
            L + GMTCS+C N + + L  ++GV    ++L+  +C++ YD+  V    +   +++ GF+ E++ +         EG+    + ++GMTC SCV+ +   +  I+G+ S+ VSL T +  V Y  S+       + I D GFD+++
Sbjct:    6 LAVHGMTCSACTNTINTQLRALKGVTKCDISLVTNECQVTYDNE-VTADSIKEIIEDCGFDCEILRDSEITAISTKEGL----LSVQGMTCGSCVSTVTKQVEGIEGVESVVVSLVTEECHVIYEPSKTTLETAREMIEDCGFDSNI 147          

Query:  559 RVIVRVNGMTCQSCVDNIESTVGKKQGIISIKVFLEKSEAHALVDASLAGPDVEEMINDMGFNSEMILEIFNDSCAGKPNNVSQKYEELKSNTIYPILSTTIVIKALKSIFCIFKIENHMRALPGVDKCSVNLIEEIGMIDYDSGKWNVQKIREEIESLGY 1041
             VI+ V+GMTC +C + I + +   +G+    + L  +E     D  +    ++E+I D GF+     EI  DS   +   +S K E L S            ++ +    C+  +   +  + GV+   V+L+ E   + Y+  K  ++  RE IE  G+
Sbjct:    3 EVILAVHGMTCSACTNTINTQLRALKGVTKCDISLVTNECQVTYDNEVTADSIKEIIEDCGFDC----EILRDS---EITAISTK-EGLLS------------VQGMTCGSCVSTVTKQVEGIEGVESVVVSLVTEECHVIYEPSKTTLETAREMIEDCGF 143          

Query: 1795 FVLATPVQFYGARYFYIQAYLSL-KHKTTNMDVLVVMATXXXXXXXXXXXXXXMAFRRNTSPKTFFETSPMLIVFLSLGRWLEHIAKGKTSEALTKLMSLQAVEATLYTPENKERKIPINLVQRNDLIKILPGEKIPVDGKVVTGTSTCDESLITGESMPIEKTHGSDVIGGSINKSGMLIVKATHVGSDSALAQIVKLVEEAQTSKAPIQQLADRIAGMFVPSVLICAIITLIIWVIVGFSKPEILPKYVNELSVTEITWEHAFQLAITVLSIACPCSLGLXXXXXXXXXXXXXXXNGILIKGGEPLENIHKLNVIVFDKTGTITNGSPSVTRFLVLIGNGVREHIDKLLKILAAAESASEHPIGKAIITFSKAR-ISNENLPEVLESSAVSG 2970
             VLAT +QF  A  FY+ A  SL   +   MD+L+V++TS +YI+S++         R  S + FFETS +L+  + +GR++  +A+ +  ++++ + SLQA  A L     KE +I I L+Q  D+ K+LP  +IP DG V++G+S  DE+LITGESMP+ K   S V+ GS+N +G L VK + +  ++ ++ I  +V+EA+ +K  IQ +AD+IA  FVP+++   ++T  +W+ VG          V + S ++   + A   AITVL ++CPC +GLA P   ++ +GV A  G++ K  E +E  H  + +VFDKTGT+T G  +V    V    G R +   LL  L   E   +HP+  AI ++ K + +S +N   V  + AV+G
Sbjct:  595 MVLATIIQFVIAGPFYLNALKSLIFSRLIEMDLLIVLSTSAAYIFSIVSFGY-FVVGRPLSTEQFFETSSLLVTLIMVGRFVSELARHRAVKSIS-VRSLQASSAILVDKTGKETEINIRLLQYGDIFKVLPDSRIPTDGTVISGSSEVDEALITGESMPVPKKCQSIVVAGSVNGTGTLFVKLSKLPGNNTISTIATMVDEAKLTKPKIQNIADKIASYFVPTIIGITVVTFCVWIAVGIR--------VEKQSRSDAVIQ-AIIYAITVLIVSCPCVIGLAVPIVFVIASGVAAKRGVIFKSAESIEVAHNTSHVVFDKTGTLTEGKLTVVHETV---RGDRHNSQSLL--LGLTEGI-KHPVSMAIASYLKEKGVSAQN---VSNTKAVTG 968          

Query: 3199 GNRNWMLRNGILVDDEVDELMSEDENLGRTVILMAIDNELIAMISVADQVKREAALAVYTLKKMNIEVYLMTGDNSKTATAIARQVGIHY--VFAEVLPSHKVAKVQQL---QNTNRSLTSKRKMKVAMVGDGINDSPALAQSDVGIAIGTGTDVAVEAADVVLIRNSLLDVIAAIQLSKATVKRIRQNFIAATLYNLLGIPIAAGVLMPIGI 3822
            GN  W+  N    D +V + + +    G +V   +++  + A+ ++ D ++ +A   +  L++  I +++++GD+     ++A ++GI    + +   P+ K   ++ +   +N + S  SKR + V   GDG ND+  L Q+ +G+ I  G++VA  AADVV+++  L +++  I +S+  + R++ NF+ +  YNL  I +AAG  +   I
Sbjct:  984 GNCRWLGHNN---DPDVRKALEQ----GYSVFCFSVNGSVTAVYALEDSLRADAVSTINLLRQRGISLHILSGDDDGAVRSMAARLGIESSNIRSHATPAEKSEYIKDIVEGRNCDSSSQSKRPV-VVFCGDGTNDAIGLTQATIGVHINEGSEVAKLAADVVMLKPKLNNILTMITVSQKAMFRVKLNFLWSFTYNLFAILLAAGAFVDFHI 1188          

Query: 2137 KIPINLVQRNDLIKILPGEKIPVDGKVVTGTSTC----DESLITGESMPIEKTHGSDVIGGSINKSGMLIVKATHVGSDSALAQIVKLVEEAQTSKAPIQQLADRIAGMFVPSVLICAIITLIIWVIVGFSKPEILPKYVNELSVTEITWEHAFQLAITVLSIACPCSLGLXXXXXXXXXXXXXXXNGILIKGGEPLENIHKLNVIVFDKTGTITNGSPSVTRFLVLIGNGVREHIDKLLKILAAAE-----SASEHPIGKAIITFSKARISNENLPEVLESSAVSGCGLGCKLNLDPKTEVTKFVKNLINIESPSEETNILGQXXXXXXXXXXXXTYKDVIFPVRQHMAWTSDLCQTVTVII---------GNRNWMLRNGIL--VD---DEVDELMSEDENLGRTVILMAIDNELIAMISVADQVKREAALA--VYTLKKMNIEVYL-MTGDNSKTATAIARQVGIHYVFAEVLPSHKVAKVQQLQNTNRSLTSKRKMKVAMVGDGINDSPALAQSDVGIAIGTGTDVAVEAADVVLIRNSLLDVIAAIQLSKATVKRI 3741
            +IP N V   +++++  G   P DG++VT    C    D+S ITGES+  EK +G +V   S  K+G   +  T  G ++ + +   LV +A   +    ++ + I  + +  VL+ A + L++W    +       + V  +S+   T      L IT+  I  P  L     T + VG    A    +++    +E++  + ++  DKTGT+T    S+     +   GV      L   LAA+       A +    K++I + KA+       + L    V        L   P   V+K V  +  +ESP  E  +  +   + +   +    +D   P   H  + + + +  +            G  +W +  G++  +D   D+  + ++E  NLG  + ++  D      + +A +  R+  L   +Y  +++ +     M G  S+ A  +    G     AEV P HK   V+ LQN        R   VAM GDG+ND+P+L ++D GIA+   TD A  AAD+V +   L  +I A++ S+    R+
Sbjct:  219 EIPANEVVPGEILQLESGTIAPADGRIVT--EDCFLQIDQSAITGESLAAEKHYGDEVFSSSTVKTGEAFMVVTATGDNTFVGRAAALVGQASGVEGHFTEVLNGIGIILL--VLVIATL-LLVWTACFY-------RTVGIVSILRYT------LGITI--IGVPVGLPAVVTTTMAVGAAYLAKKQAIVQKLSAIESLAGVEILCSDKTGTLTKNKLSLHEPYTV--EGVSPDDLMLTACLAASRKKKGLDAIDKAFLKSLIEYPKAK-------DALTKYKV--------LEFHPFDPVSKKVTAV--VESPEGERIVCVKGAPLFVLKTVE---EDHPIPEDVHENYENKVAELASRGFRALGVARKRGEGHWEIL-GVMPCMDPPRDDTAQTINEARNLGLRIKMLTGD-----AVGIAKETCRQLGLGTNIYNAERLGLGGGGDMPG--SELADFVENADGF----AEVFPQHKYRVVEILQN--------RGYLVAMTGDGVNDAPSLKKADTGIAVEGATDAARSAADIVFLAPGLSAIIDALKTSRQIFHRM 717          

Query: 3307 DNELIAMISVADQVKREAALAVYTLKKMNIEVYLMTGDNSKTATAIARQVGIHY-----------------------------VFAEVLPSHKVAKVQQLQNTNRSLTSKRKMKVAMVGDGINDSPALAQSDVGIAIGT-GTDVAVEAADVVLIRNSLLDVIAAIQLSKATVKRIRQNFIAATL 3768
            D     +I + D  +     A+  L +  + + ++TGD+  TA  IA+Q+GI                               +FA   P HK+  V+ L+        KR   VAM GDG+ND+PAL  SD+G+++G  GTDVA EA+D+VL  +    ++ AI+  K     I QNF+   L
Sbjct:  569 DLTFTGLIGMNDPPRPNVKFAIEQLLQGGVHIIMITGDSENTAVNIAKQIGIPVIDPKLSVLSGDKLDEMSDDQLANVIDHVNIFARATPEHKLNIVRALR--------KRGDVVAMTGDGVNDAPALKLSDIGVSMGRIGTDVAKEASDMVLTDDDFSTILTAIEEGKGIFNNI-QNFLTFQL 743          

Query: 3316 LIAMISVADQVKREAALAVYTLKKMNIEVYLMTGDNSKTATAIARQVGI------HY-------------------------------VFAEVLPSHKVAKVQQLQNTNRSLTSKRKMKVAMVGDGINDSPALAQSDVGIAIG-TGTDVAVEAADVVLIRNSLLDVIAAIQLSKATVKRIRQNFIAATLYNLLGIPIAAGVLMPIGI 3822
             + +I + D  + E A AV    +  I V+++TGD   TA AIA++VGI      HY                               V A   P  KV  ++ L         +RK   AM GDG+NDSP+L  ++VGIA+G  G+DV+ EA+D+VL  ++   ++ A++  +     I Q F+      LL   +A  + + IG+
Sbjct:  641 FLGLIGIYDPPRNETAGAVKKFHQAGINVHMLTGDFVGTAKAIAQEVGILPTNLYHYSQEIVDSMVMTGSQFDGLSEEEVDDLPVLPLVIARCSPQTKVRMIEALH--------RRKKFCAMTGDGVNDSPSLKMANVGIAMGINGSDVSKEASDIVLSDDNFASILNAVEEGRRMTDNI-QKFV----LQLLAENVAQALYLIIGL 834          

Query:  574 VNGMTCQSCVDNIESTVGKKQGIISIKVFLEKSEAHALVDASLAGPD-VEEMINDMGFNSEMILEIFNDSCAGKPNNVSQKYEELKSNTIYPILSTTIVIKALKSIFCIFKIENHMRALPGVDKCSVNLIEEIGMIDYDSGKWNVQKIREEIESLGY----------LTELPKQ---NWN---STRQSSAVSLNEESRSKCYLRITGMTCSSCVNKVESHLLKVEGVKSVLVALLAMKCEIIYDSAYVMPFQLSNRVKELGFNAEVIENGNEGIGIVNVLIRGMTCSSCVNHIENHISKIKGIASINVSLSTSKGKVEYFISECGPRDVIDAINDMGFDASLCDHLESNHAAADHINQMIKQWRSSFFFSLICGIPXXXXXXXXXXXXXXXXHTIIHENGSNRTIMKSTVPMVCSGLSADNLILFVLATPVQFYGARYFYIQAYLSLKHKTTNMDVLVVMATXXXXXXXXXXXXXXMAFRRNTSPKTFFETSPMLIVFLSLGRWLEHIAKGKTSEALTKLMSLQAVEATLYTPE------NKERKIPINLVQRNDLIKILPGEKIPVDGKVVTGTSTCDESLITGESMPIEKTHGSDVIGGSINKSGMLIVKATHVGSDSALAQIVKLVEEAQTSKAPIQQLADRIAGMFVPSVLICAIITLIIWVIVGFSKPEILPKYVN--ELSVTEITWEHAFQLAITVLSIACPCSLGLXXXXXXXXXXXXXXXNGILIKGGEPLENIHKLNVIVFDKTGTITNGSPSVTRFLVLIGNGVREHIDKLLKILAAAESASEHPIGKAIITFSKARISNENLPEVLESSAVSGCGLGCKLN------LDPKTEVTKFVKNLINIESPSEETNILGQXXXXXXXXXXXXTYKDVIFPVRQHMAWTSDLCQTVTVIIGNRNWMLRNGILVDDEVDELMSEDENLGRTVILMAIDNELIAMISVADQVKREAALAVYTLKKMNIEVYLMTGDNSKTATAIARQVGIHYVFAEVLPSHKVAKVQQLQNTNRSLTSKRKMKVAMVGDGINDSPALAQSDVGIAIGTGTDVAVEAADVVLIRNSLLDVIAAIQLSKATVKRIRQNFIAATLYNLLGIPIAAGVLMPIGIEMMPWM 3840
            V+GMTCQSCV +IE  + K  G++++KV L K  A       L  P+ + E+I D GF  E++L          P + S   +           S  I ++ +    C+  IE ++  L GV    V+L ++   +++   K   +++RE IE +G+             +  Q   +W    S+R+        E   K YL I GMTC+SCV  +E  L K EGVKSVLV LLA K E+ Y+   +   ++   V  +GF  E+++   +G  +V++ I GMTCSSCV+ IE+ + K  GI   +V+L+TS G+ +Y     GPRD+I+AI  +GF A+L D   S+    DH    IK+WR SF  SLI G+P   + +          +  + E G    +M      V  GLS +NL++F+L TPVQ  G R+FY+ AY +LKH++TNMDVL+++AT+I+Y+YS++V V++M+ + + SP TFF+T PML+VF+SLGRW+EH+AKGKTSEAL KL+SLQ   A L   +       +E  I ++LVQR D++K++PG KIPVDG+V+ GTS  DESLITGESMP+ K  G  VIGG++N++G ++++ATHVG D+ LAQIVKLVEEAQTSKAPIQ+ AD ++G FVP V++ +I T +IWVI+G+S   I+    N  E +  E     AFQ+ ITVL+IACPC+LGLATPTAVMVGTG+GA NGILIKGGEPLE  HK+  +VFDKTGT+T+G P V +  + +   + + +  LL +   AE++SEHP+G AI T++K  +S ENL       A  G GL C ++      L+P    +K  K+       S + N++         D ++      I+  R        L +   V+IGNR+WM +NG++V DE++E M   E +G T IL+ I + L+ M++VAD VK EA +AV TLK+M + V L+TGDN KTA AIARQVGI  VFAEVLPSHKV K++ LQ         +    AMVGDGINDSPALAQ+ VGIAIGTGTDVAVEAAD+VLI++ L+DV AAI LS+ TV+RI  NF  A LYN++GIP AAGV  P+G+ M PWM
Sbjct:   96 VHGMTCQSCVKSIEKALSKSTGVLNVKVSLPKESAVIKYRKLLTSPEKLAELIEDAGF--EVVL----------PRSGSTDVK-----------SVMITVQGMTCNSCVNTIEKNISKLDGVQSVKVSLDDKCARLEFAPEKVTPEQMREAIEDMGFDALLLGNVDEFVAVAGQMTGDWGVRFSSRKKHVEQDPLEDVEKIYLHIEGMTCASCVASIERALSKKEGVKSVLVGLLAQKAEVKYNKNRITTDEIVYHVTAMGFGCELMDKTGQGENVVDIRISGMTCSSCVHLIESSLIKRPGILQTSVALATSSGRFKYDTEITGPRDIIEAIKGLGFGAALADS-SSSKDKVDH-TLSIKKWRRSFLVSLIFGLPVFAIFIS---------YVFLEEAGKRPHVM------VIPGLSLENLLMFLLCTPVQILGGRHFYVTAYKALKHRSTNMDVLIMLATTIAYVYSIVVCVVAMSEQSSHSPMTFFDTPPMLLVFISLGRWMEHVAKGKTSEALAKLLSLQPATAMLVKLKPGSHQITEETVISVDLVQRADVLKVVPGAKIPVDGRVIEGTSMADESLITGESMPVPKKVGDSVIGGTMNQNGAILIEATHVGQDTTLAQIVKLVEEAQTSKAPIQKFADTLSGYFVPIVILISIATFMIWVIIGYSDITIIRMVYNPKEDNRDEFIIGFAFQIGITVLAIACPCALGLATPTAVMVGTGIGAQNGILIKGGEPLETAHKVTAVVFDKTGTLTHGKPEVVKTALFVSPDICD-LQLLLAVAGTAENSSEHPLGVAITTYAKKELSTENLGICSGFKAQPGYGLTCTVSGVEDLLLEPNQRQSKTSKD-------STQGNLILPVDGSIARDFVKADLDSTIYDCR--------LGKQYKVLIGNRDWMQQNGLVVTDEMEEDMVAHETIGHTAILIGIRDSLVGMMAVADTVKNEAQVAVSTLKRMGLRVVLLTGDNKKTAMAIARQVGIQQVFAEVLPSHKVEKIRALQ--------AKGFVTAMVGDGINDSPALAQAHVGIAIGTGTDVAVEAADIVLIKSDLMDVAAAIDLSRVTVRRIHLNFAFALLYNMIGIPFAAGVFEPLGVVMKPWM 1151          

Query:  118 VDGMTCMSCVRNIEENLMKFTGVCGIMVSLLHAEATVIFDADIATVEDISNKIDEMGFDVTVK-------SSEVSNVKDKVVRSRIKFESDINKSVE--------KSIETSL--SSKLLLVRFCQENNYADIWHYSSIRSTEILSVIQQSEIYGVLVLEQCPT--IRVIVRVNGMTCQSCVDNIESTVGKKQGIISIKVFLEKSEAHALVDASLAGPD-VEEMINDMGFNSEMILEIFND-SCAGKPNN-----VSQKYEELKSNTIYPILSTTIVIKALKSIFCIFKIENHMRALPGVDKCSVNLIEEIGMIDYDSGKWNVQKIREEIESLGYLTELPKQNWNSTRQSSAVSLNEESRSKCYLRITGMTCSSCVNKVESHLLKVEGVKSVLVALLAMKCEIIYDSAYVMPFQLSNRVKELGFNAEVIEN 1329
            ++GMTC SCV+ IE ++   +GV  I VSL   EA V FD  I     ++N ID+MGF+  +K         EV+  K   +++  + E +I  +V         KSIE +L  S+ +L V+       A I +   + S E L+ + +   + V++     T    V++ V GMTC SCV+ IE  + K  G+ S+KV L+   A          P+ + E I DMGF++ ++  +    + AG+         S + + ++ + +  +    + I+ +    C+  IE  +    GV    V L+ +   + Y+  +    +I   + ++G+  EL     + T Q   V           +RI+GMTCSSCV+ +ES L+K  G+    VAL        YD+    P  +   +K LGF A + ++
Sbjct:    1 MEGMTCNSCVKTIETSMSSTSGVKNIKVSLEEKEAEVTFDPKITNGTSLANAIDDMGFEACLKRVVDILTKQEVAQSKGTSIKNADEREEEIEFTVHGMTCQSCVKSIEKALSKSTGVLNVKVSLPKESAVIKYRKLLTSPEKLAELIEDAGFEVVLPRSGSTDVKSVMITVQGMTCNSCVNTIEKNISKLDGVQSVKVSLDDKCARLEFAPEKVTPEQMREAIEDMGFDALLLGNVDEFVAVAGQMTGDWGVRFSSRKKHVEQDPLEDVEKIYLHIEGMTCASCVASIERALSKKEGVKSVLVGLLAQKAEVKYNKNRITTDEIVYHVTAMGFGCEL----MDKTGQGENV---------VDIRISGMTCSSCVHLIESSLIKRPGILQTSVALATSSGRFKYDTEITGPRDIIEAIKGLGFGAALADS 417          

Query:  892 CIFKIENHMRALPGVDKCSVNLIEEIGMIDYDSGKWNVQKIREEIESLGY-------LTELPKQNWNSTRQSSAVSLNEESRSKCYLRITGMTCSSCVNKVESHLLKVEGVKSVLVALLAMKCEIIYDSAYVMPFQLSNRVKELGFNAEVIENGNEGIGIVNVLIRGMTCSSCVNHIENHISKIKGIASINVSLSTSKGKVEYFISECGPRDVIDAINDMGFDASLCDHLESNHAAADHINQMIKQWRSSF 1623
            C+  IE  M +  GV    V+L E+   + +D    N   +   I+ +G+       +  L KQ    ++ +S +   +E   +    + GMTC SCV  +E  L K  GV +V V+L      I Y      P +L+  +++ GF   +  +G+  +  V + ++GMTC+SCVN IE +ISK+ G+ S+ VSL     ++E+   +  P  + +AI DMGFDA L  +++   A A    QM   W   F
Sbjct:    9 CVKTIETSMSSTSGVKNIKVSLEEKEAEVTFDPKITNGTSLANAIDDMGFEACLKRVVDILTKQEVAQSKGTS-IKNADEREEEIEFTVHGMTCQSCVKSIEKALSKSTGVLNVKVSLPKESAVIKYRKLLTSPEKLAELIEDAGFEVVLPRSGSTDVKSVMITVQGMTCNSCVNTIEKNISKLDGVQSVKVSLDDKCARLEFAPEKVTPEQMREAIEDMGFDALLLGNVDEFVAVA---GQMTGDWGVRF 255          

Query:  103 SARMKVDGMTCMSCVRNIEENLMKFTGVCGIMVSLLHAEATVIFDADIATVEDISNKIDEMGFD----------VTVKSSEVSNVKDKVVRSRIKFESDINKSVEK---------------SIETSLSSK-----LLLVRFCQENNYADIWHYSSIRSTEILSVIQQSEIYGVLVLEQCPTIR--VIVRVNGMTCQSCVDNIESTVGKKQGIISIKVFLEKSEAHALVDASLAGP-DVEEMINDMGFNSEM 756
            S  + V GMTC SCV  IE+N+ K  GV  + VSL    A + F  +  T E +   I++MGFD          V V      +   +    +   E D  + VEK               SIE +LS K     +L+    Q+      ++ + I + EI+  +     +G  ++++       V +R++GMTC SCV  IES++ K+ GI+   V L  S      D  + GP D+ E I  +GF + +
Sbjct:  167 SVMITVQGMTCNSCVNTIEKNISKLDGVQSVKVSLDDKCARLEFAPEKVTPEQMREAIEDMGFDALLLGNVDEFVAVAGQMTGDWGVRFSSRKKHVEQDPLEDVEKIYLHIEGMTCASCVASIERALSKKEGVKSVLVGLLAQKAEVK--YNKNRITTDEIVYHVTAMG-FGCELMDKTGQGENVVDIRISGMTCSSCVHLIESSLIKRPGILQTSVALATSSGRFKYDTEITGPRDIIEAIKGLGFGAAL 414          

Query: 1708 IHENGSNRTIMKSTVPMVCS--GLSADNLILFVLATPVQFYGARYFYIQAYLSLKHKTTNMDVLVVMATXXXXXXXXXXXXXXMAFRRNTSPKTFFETSPMLIVFLSLGRWLEHIAKGKTSEALTKLMSLQAVEATLYTPENKERKIPINLVQRNDLIKILPGEKIPVDGKVVTGTSTCDESLITGESMPIEKTHGSDVIGGSINKSGMLIVKATHVGSDSALAQIVKLVEEAQTSKAPIQQLADRIAGMFVPSVLICAIITLIIWVIVGFSKPEILPKYVNELSVTEITWEHAFQLAITVLSIACPCSLGLXXXXXXXXXXXXXXXNGILIKGGEPLENIHKLNVIVFDKTGTITNGSPSVTRFLVLIGNGVREHIDKLLKILAAAESASEHPIGKAIITFSKARISNENLPEVLESSAVSGC-GLGCKLNLDPKTEVTKFVKNLINIESPSEETNILGQXXXXXXXXXXXXTYKDVIFPVRQHMAWTSDLCQTVTVIIGNRNWMLRNGILVDDEVDELMSED--------ENLGRTVILMAIDNELIAMISVADQVKREAALAVYTLKKMNIEVYLMTGDNSKTATAIARQVGIHYVFAEVLPSHKVAKVQQLQNTNRSLTSKR---KMKVAMVGDGINDSPALAQSDVGIAIGT-GTDVAVEAADVVLIRNSLLDVIAAIQLSKATVKRIRQNFIAATLYNL 3777
            + E G++  + K TV  + +  GL         +A     +G+     +A++S+K+   +++VL+++A                      +   + E + ++ VF +L   +E  +  K    +++LM  +   A L   E  E  + I+ V    LI + PG+ IP+DG VV G ++ DES ITGE +P+EK   S V  G+++++G L +K T   S+S ++++ ++V+EAQ+S    +Q+ +  A  + P V++ + + + I  I+G +      + ++E       W H    A+ +L +ACPC+L + +P AV+      A  G LIK GE LE + KL V+ FDKTGT+T G   VT    + G   RE    +L++ A  ES S HPI  AI+        NE           SGC G   K N+    EV KF           E   I G                               + +   V++GN +       LV D+  E +            N  +TV+ +++++++  M+++AD ++     A+  L+   I+  ++TGDN++TA A+   +G+    AE+ PS K+       + +     +R   ++ V MVGDG+ND PALA +D+GIA+G  GT +AVEAADV L+ N+L  +   + L K     I QN   + +  L
Sbjct:   66 VMETGNHHGVEKHTVLFIVAVVGLFLKTKWFMWVAIAEILFGSIPILKRAFISMKNLRVDINVLMLIAIIG-----------------TAALSDWVEGATVVYVF-ALADAIEEYSLHKVQRTISRLMLKRPQVAVLV--ETGE-VVNIDTVVIGTLIAVRPGDLIPLDGIVVKGRASVDESSITGECLPVEKKVDSKVFSGTVDQNGYLEIKTTTDSSNSTVSRVAEMVQEAQSSSTRTEQIINHFAKYYTPLVVVTSALVIAIPAILGVAGVGTYQQDLHE-------WGHK---ALVLLVVACPCALVMTSPIAVVCSITAAARRGSLIKKGEHLETLAKLEVLAFDKTGTLTEGKFQVTDMESVYGVNERE----VLRLAAGIESKSSHPIAAAIV--------NE----------FSGCVGSMVKSNVFSIPEVKKF--------KLHEGKGISG-------------------------------IVEGKKVLVGNHS-------LVTDQCGEKLGSSMTDKYIQWSNESKTVVFVSVNSKVQLMVALADSIRPNTIDALDWLRHHGIQTSMITGDNARTAAAVKESLGLDECTAEMKPSDKL-------DPHFCCVRRRNVGRVSVGMVGDGVNDGPALAAADLGIAMGAGGTALAVEAADVTLMSNNLAKIPELVSLGKFCRTIITQNIALSVVLKL 664          

Query: 3367 AVYTLKKMNIEVYLMTGDNSKTATAIARQVGIHY---------------------------VFAEVLPSHKVAKVQQLQNTNRSLTSKRKMKVAMVGDGINDSPALAQSDVGIAIG-TGTDVAVEAADVVLIRNSLLDVIAAIQLSKATVKRIRQNFI 3756
            AV TL    ++V ++TGD+ +TA  IA  +GIH+                           VF  V P HKVA V+ LQ             VAM GDG+ND+ AL ++D+GIA+G +GTDV+ EAA+++L+ +    ++AAI+  K     I+ NF+
Sbjct:  546 AVRTLLDSGVQVKMITGDSRETAITIAELLGIHFKGRPTLSGEELEALDGLQLSTIIDQVSVFYRVSPRHKVAIVKALQQHGHV--------VAMTGDGVNDAVALKRADIGIAMGKSGTDVSKEAAEMILVDDDFNTIMAAIEEGKGIFYNIK-NFV 694          

Query: 3316 LIAMISVADQVKREAALAVYTLKKMNIEVYLMTGDNSKTATAIARQV----------GIHY---------------------VFAEVLPSHKVAKVQQLQNTNRSLTSKRKMKVAMVGDGINDSPALAQSDVGIAIGTGTDVAVEAADVVLIRNSLLDVIAAIQLSKATVKRIRQ---NFIAATLYNLLGIPIAAGVLMP 3813
             + +  + D  + E   A+    K  I V ++TGDN  TA AI R++          G+ Y                     +F+ V PSHK   V  LQ              AM GDG+ND+PAL ++++G+A+G+GT VA  A++++L  ++   ++AA++  ++     +Q     I++ +  ++ I + A + MP
Sbjct:  596 FVGVAGMLDPPRPEVTDAIKLCAKAGIRVIVITGDNKATAEAICRRIEVFGQDEDTTGLSYSGREFDDLTPSEQREACLRARLFSRVEPSHKSKIVTYLQEEGEI--------SAMTGDGVNDAPALKKAEIGVAMGSGTAVAKTASEMILADDNFSTIVAAVEEGRSIYDNTKQFIRYLISSNIGEVVSIFLTAALGMP 787          

Query: 3319 IAMISVADQVKREAALAVYTLKKMNIEVYLMTGDNSKTATAIARQVGI---------------------------HYVFAEVLPSHKVAKVQQLQNT--------NRSLTSKRKMKVAMVGDGINDSPALAQSDVGIAIG-TGTDVAVEAADVVLIRNSLLDVIAAIQLSKATVKRIRQNFIAATLYNLLGIPIA 3795
            IA+  + D V++E   A+   ++  I V ++TGDN  TA +IA + GI                              F E+ P  +V      ++         +  L   R++ VA+ GDG ND PAL ++DVG A+G  GTDVA EA+D++L  ++   ++ A+   +     I +        NL+ I IA
Sbjct:  651 IAIAGIEDPVRQEVPAAIKKCQQAGIVVRMVTGDNVNTARSIAGKCGILEPDKDFLVLDGKEFNKLIRDSNGRVSQKKFDEIWPRLRVLARSSPEDKYTLVKGIIDSKLNPAREI-VAVTGDGTNDGPALKKADVGFAMGIAGTDVAKEASDIILTDDNFRSIVMAVMWGRNVYDSISKFLQFQLTVNLVAIVIA 844          

Query:  109 RMKVDGMTCMSCVRNIEENLMKFTGVCGIMVSLLHAEATVIFDADIATVEDISNKIDEMGFDVTVKSSEVSNVKDKVVRSRIKFESDINKSVEKSIETSLSSKLLLVRFCQENNYADIWHYSSIRSTEILSVIQQSEIYGVLVLEQCPTIRVIVRVNGMTCQSCVDNIESTVGKKQGIISIKVFLEKSEA-----------HALVDASLAGPDVEEMINDMGFNSEMILEIFNDSCAGKPNNVSQ-KYEELKSNTIYPILSTT-IVIKALKSIFCIFKIENHMRALPGVDKCSVNLIEEIGMIDYDSGKWNVQKIREEIESLGYLTELPKQNWN-----STRQSSAVSLNEE-------------SRSKCYLRITGMTCSSCVNKVESHLLKVEGVKSVLVALLAMKCEIIYDSAYVMPFQLSNRVKELGFNAEVIENGNEGIGIVNVLIRGMTCSSCVNHIENHISKIKGIASINVSLSTSKGKVEYFISECGPRDVIDAINDMGFDASLCDHLESNHAAADHINQMIKQWRSSFFFSLICGIPXXXXXXXXXXXXXXXXHTIIHENGS--NRTIMKSTVPM---VCSGLSADNLILFVLATPVQFYGARYFYIQAYLSLKHKTTNMDVLVVMATXXXXXXXXXXXXXXMAFRRNTSPKTFFETSPMLIVFLSLGRWLEHIAKGKTSEALTKLMSLQAVEATLYT--PEN---KERKIPINLVQRNDLIKILPGEKIPVDGKVVTGTSTCDESLITGESMPIEKTHGSDVIGGSINKSGMLIVKATHVGSDSALAQIVKLVEEAQTSKAPIQQLADRIAGMFVPSVLICAIITLIIWVIVGFSK----PEILPKYVNELSVTEITWEHAFQLAITVLSIACPCSLGLXXXXXXXXXXXXXXXNGILIKGGEPLENIHKLNVIVFDKTGTITNGSPSVTRFLVLIGNGVREHIDKLLKILAAAESASEHPIGKAIITFSKARISNENLPEVLESSAVSGCGLGCKLNLDPKTEVTKFVKNLINIESPSEETNILGQXXXXXXXXXXXXTYKDVIFPVRQHMAWTSDLCQTVTVIIGNRNWMLRNGILVDDEVDELMSEDENLGRTVILMAIDNELIAMISVADQVKREAALAVYTLKKMNIEVYLMTGDNSKTATAIARQVGIHYVFAEVLPSHKVAKVQQLQNTNRSLTSKRKMKVAMVGDGINDSPALAQSDVGIAIGTGTDVAVEAADVVLIRNSLLDVIAAIQLSKATVKRIRQNFIAATLYNLLGIPIAAGVLMPIGIEMMPWMXXXXXXXXXXXXXXXXXXXXXWKKPSEEKL 3930
            +++++GMTC SCV  IE  + K  G+  I V L   EAT+I+   + T + I  +I   GF  +VKS                          K     LS++             DI  ++  +   + S  +++E++         T  V++ V GM C+SCV NI+  +    G+ S++V LEK +A            AL  A  A P     +   G  + +       S   +P  V+Q K   L+     P++ST  I I+ +    C+  IE  +    GV    V+L +  G+ +YD    + Q++RE +E +G+   LP+ N       +T  S+A    +E             + SKCY++I GMTC+SCV+ +E +L    G+  VLVAL+A K E+ Y+   + P ++   VKELGF A V+EN     G + ++IRGMTC+SCV+ IE+++ K KGI   +V+L+T+K  V++     GPRD+I  I ++GF ASL    + + +  DH ++ I+QWR SF  SLI  +P M +M++ M     +  +  H N +  +R    ST+ +   +  GLS  NL+ F+   PVQF G RYFYIQAY +LKHK+ NMDVL+V+ATS+++ YS++V++++M  R   +P TFF+T PML VF+SLGRWLE IAK KTSEAL+KLMSLQA EAT+ T   +N    E ++ + LVQR D++K++PG K PVDG+V+ G S  DESLITGE+MP+ K  GS VI GSIN++G L+V ATHVG D+ L+QIVKLVEEAQTSKAPIQQ AD+I+G FVP ++  +++TLI+W+I+GF       +  P Y   +S +E     AFQ +ITVL IACPCSLGLATPTAVMVGTGVGA NGILIKGGEPLE  HK+  +VFDKTGTIT G+P V +   ++  G +  + +LL I+  AE+ SEHP+G AI  + K  +  E+L    +  AV GCG+ C+++ + +T V +        +S SE+ N     +    +     +   +I   +   +  +DL     V+IGNR WM RN + +  E+DE M E E  GRT +L+A++N L AMI+++D VK EA LAV TL  M +EV LMTGDNSKTA  IA QVGI  VFAEVLPSHKVAKV+QLQ   +         VAMVGDG+NDSPALA +DVGIAIGTGTDVA+EAADVVLIRN LLDV+ +I LSK TVKRIR NF+ A +YNL+GIPIAAGV +PIG+ + PWM SAAMA SSVSVV  SLLLK + KP+ EKL
Sbjct:  166 KLRIEGMTCHSCVTTIEGKIGKLNGIQKIKVVLESKEATIIYLPYLITHQSIVEQIAFAGFKASVKS--------------------------KPKPLQLSNR-------------DIERFADSQKATLTSSSEETEVF-------IDTTLVLLGVKGMHCRSCVVNIQDNISLLPGVSSVEVSLEKEQATICYDPHKVTVSALQQAIEALPPGNFKVEAPGSTNPVT------SARAQPACVTQAKPAALQPCFTQPLVSTVNIHIEGMTCNSCVQSIEGMISQRKGVVSAQVSLADHQGIFEYDPLLTSPQELREAVEDMGFDAFLPETNSLLEPNITTSASTAPDQGKEFDPKEAHRGSTEGTHSKCYIQIGGMTCASCVSNIERNLKNEPGIYFVLVALMASKAEVRYNPEVIDPPKIVECVKELGFTASVMENYEGSNGNLELVIRGMTCASCVHKIESNLMKEKGIEYASVALATNKAHVKFDSEVLGPRDIIKLIENLGFKASLVKR-DRSASHLDH-SKEIRQWRKSFLISLIFCVPVMGMMIYMMVMDHHMNASH-HHNATVEDRNHYHSTMFLERQLFPGLSIMNLLSFIFCVPVQFIGGRYFYIQAYKALKHKSANMDVLIVLATSVAFSYSLVVLIVAMVERAKVNPITFFDTPPMLFVFISLGRWLEQIAKSKTSEALSKLMSLQATEATVVTLGSDNVILSEEQVDVELVQRGDVVKVVPGGKFPVDGRVLEGHSMADESLITGEAMPVTKKPGSTVIAGSINQNGSLLVSATHVGMDTTLSQIVKLVEEAQTSKAPIQQYADKISGYFVPFIVAVSLLTLIVWIIIGFLDFSLVKKYFPGYNESISRSETVIRFAFQASITVLCIACPCSLGLATPTAVMVGTGVGAQNGILIKGGEPLEMAHKVQAVVFDKTGTITYGAPKVVQVKTVV-EGNKMPLSRLLAIVGTAENNSEHPLGAAITKYCKQELGTESLGTCTDFQAVPGCGVRCQVS-NTETVVKQG-------DSDSEDNNHRNSVLVQISDTRTSSSSHPLIMDPQPLSSGPTDL---YVVLIGNREWMRRNFLEITAEIDEAMMEHERRGRTAVLVAVNNMLCAMIAISDTVKPEAELAVQTLTNMGLEVVLMTGDNSKTARVIAAQVGIRKVFAEVLPSHKVAKVEQLQQAGKI--------VAMVGDGVNDSPALAMADVGIAIGTGTDVAIEAADVVLIRNDLLDVVGSIDLSKKTVKRIRINFVFALIYNLVGIPIAAGVFLPIGLVLQPWMGSAAMALSSVSVVVSSLLLKCYTKPTAEKL 1409          

Query:   88 RMKLGSARMKVDGMTCMSCVRNIEENLMKFTGVCGIMVSLLHAEATVIFDADIATVEDISNKIDEMGFDVTVKSSEVSNVKDKVVRSRIKFESDINKSVEKSIETSLSSKLLLVRFCQENNYADIWHYSSIRSTEILSVIQQSEIYGVLVLEQCPTIR--------VIVRVNGMTCQSCVDNIESTVGKKQGIISIKVFLEKSEAHALVDASL-AGPDVEEMINDMGFN------------SEMILEIFNDSCAGKPNNVSQKYEELKSNTIYPILSTTIVIKALKSIF---CIFKIENHMRALPGVDKCSVNLIEEIGMIDYDSGKWNVQKIREEIESL---GYLTELPKQN--WNSTRQSSA--VSLNEESRSKCY---------LRITGMTCSSCVNKVESHLLKVEGVKSVLVALLAMKCEIIYDSAYVMPFQLSNRVKELGFNA------------------------------EVIENGNEGI-GIVNVLIRGMTCSSCVNHIENHISKIKGIASINVSLSTSKGKVEYFISECGPRDVIDAINDMGFDASLCDHLESNHA 1575
            ++ L S  +KV+GMTC SCV++IE+ +    GV  I VSL    AT+IFD    + E +S  I++MGF+ +      +        +++   S +  +  +     LS    ++  C+  +  D+ H +   S  ++S ++ S++   L L    T +        + +R+ GMTC SCV  IE  +GK  GI  IKV LE  EA  +    L     + E I   GF             S   +E F DS      + S++ E          + TT+V+  +K +    C+  I++++  LPGV    V+L +E   I YD  K  V  +++ IE+L    +  E P       S R   A        +   C+         + I GMTC+SCV  +E  + + +GV S  V+L   +    YD     P +L   V+++GF+A                              E      EG      + I GMTC+SCV++IE ++    GI  + V+L  SK +V Y      P  +++ + ++GF AS+ ++ E ++ 
Sbjct:    4 KVNLCSVALKVEGMTCGSCVQSIEQRIGSLPGVIHIRVSLEQKTATLIFDQGQQSPESLSEAIEDMGFESSFPDGSTATAVS--TETQLIPTSALAPAAHQEAREKLSQTKGVLEVCESPSQKDL-HITFAPS--LISTLELSKVVESLTLADVQTSKMKDDGVALLKLRIEGMTCHSCVTTIEGKIGKLNGIQKIKVVLESKEATIIYLPYLITHQSIVEQIAFAGFKASVKSKPKPLQLSNRDIERFADSQKATLTSSSEETEVF--------IDTTLVLLGVKGMHCRSCVVNIQDNISLLPGVSSVEVSLEKEQATICYDPHKVTVSALQQAIEALPPGNFKVEAPGSTNPVTSARAQPACVTQAKPAALQPCFTQPLVSTVNIHIEGMTCNSCVQSIEGMISQRKGVVSAQVSLADHQGIFEYDPLLTSPQELREAVEDMGFDAFLPETNSLLEPNITTSASTAPDQGKEFDPKEAHRGSTEGTHSKCYIQIGGMTCASCVSNIERNLKNEPGIYFVLVALMASKAEVRYNPEVIDPPKIVECVKELGFTASVMENYEGSNG 557          

Query:  562 VIVRVNGMTCQSCVDNIESTVGKKQGIISIKVFLEKSEAHALVDA-SLAGPDVEEMINDMGFNSEMILEIFNDSCAGKPNNVSQKYEELKSNTIYPILSTTIVIKALKSIFCIFKIENHMRALPGVDKCSVNLIEEIGMIDYDSGKWNVQKIREEIESLGYLTEL--PKQNWNSTRQSSAVSLNEESRS----------------------KCYLRITGMTCSSCVNKVESHLLKVEGVKSVLVALLAMKCEIIYDSAYVMPFQLSNRVKELGFNAEVIENGNEGIGIVNVLIRGMTCSSCVNHIENHISKIKGIASINVSLSTSKGKVEYFISECGPRDVIDAINDMGFDASLCDHLESNHAAADHINQMIKQWRSSFFFSLICGIPXXXXXXXXXXXXXXXXHTIIHENGSNRTIMKSTVPMVCSGLSADNLILFVLATPVQFYGARYFYIQAYLSLKHKTTNMDVLVVMATXXXXXXXXXXXXXXMAFRRNTSPKTFFETSPMLIVFLSLGRWLEHIAKGKTSEALTKLMSLQAVEATLYT--PENK---ERKIPINLVQRNDLIKILPGEKIPVDGKVVTGTSTCDESLITGESMPIEKTHGSDVIGGSINKSGMLIVKATHVGSDSALAQIVKLVEEAQTSKAPIQQLADRIAGMFVPSVLICAIITLIIWVIVGFSK----PEILPKYVNELSVTEITWEHAFQLAITVLSIACPCSLGLXXXXXXXXXXXXXXXNGILIKGGEPLENIHKLNVIVFDKTGTITNGSPSVTRFLVLIGNGVREHIDKLLKILAAAESASEHPIGKAIITFSKARISNENLPEVLESSAVSGCGLGCKL-NLDPKTEVTKFVKNLINIESPSEETNILGQXXXXXXXXXXXXTYKDVIFPVRQHMAWTSDLCQTVTVIIGNRNWMLRNGILVDDEVDELMSEDENLGRTVILMAIDNELIAMISVADQVKREAALAVYTLKKMNIEVYLMTGDNSKTATAIARQVGIHYVFAEVLPSHKVAKVQQLQNTNRSLTSKRKMKVAMVGDGINDSPALAQSDVGIAIGTGTDVAVEAADVVLIRNSLLDVIAAIQLSKATVKRIRQNFIAATLYNLLGIPIAAGVLMPIGIEMMPWMXXXXXXXXXXXXXXXXXXXXXWKKPSEEKLITPEYINFIQSSGLSESQIIVRRGID 4008
            V ++V+GM C+SCV++IE  + +  G++ I+V LE+++A  +     +   ++++ I DMGF++ ++L+   ++ +G    V +            I +TTI I  +    C+  IE  +    GV    V+L EE   I +D G    +++R  IE +G+   L  P+++  +  +S +V   ++ +S                      KC++ + GMTC+SCV  +E ++LK  G+ SVLV+L+A K E+ YD+  +    ++  +++LGF A++IE+     G +++ I GMTC+SCV+ IE+ +   KGI   +V+L+T K  +++     GPRD+I  I  +GF+ASL      N+   DH  + I+QWR+SF FSL+ G+P M +M++ M        T+  E+G +    ++  P    GLS  NLI F+L TPVQ +G RYFYIQAY SLKH T NMDVL+V+AT+I+Y+YS +V+VI+M  R + SP TFF+T PML VF+SLGRWLEH+AK KTSEAL KLMSLQA +AT+ T  P++    E ++ + LVQR D++KI+PG K P+DGKV+ G+S  DESLITGE MP+ KT GS VI GSIN  G L+V+ATHVG+++ L+QIVKLVEEAQTSKAPIQQ ADRI+G FVP ++  ++ TL+ W+++GF       E  P Y   +S  E+    AFQ +ITVLSIACPCSLGLATPTAVMVGTGVGA NGILIKGGEPLE  HK+NV++FDKTGTITNG P VTR LVL     R  + ++L ++  AE++SEHP+G A+    K  + ++ +    +  AV GCG+ C++ N+D   +   F+       + ++E+++L                                   + +V+IGNR WM RNG+ +  +VD  MS  E  G+T +L+AID  L AMI++AD VK E+ALAV+TL  M +EV ++TGDN  TA AIA QVGI  VFAEVLPSHKVAKVQ+LQ        +R ++VAMVGDGINDSPALA +DVGIAIGTGTDVA+EAAD+VLIRN+LLDV+A+I+LSK TV+RIR NF+ A +YNLLGIPIAAGV MP+G+ + PWM SAAMAASSVSVV  SLLL+ ++K S E   +  ++       L  SQI    G+D
Sbjct:  156 VQMKVDGMHCRSCVESIERRIRELPGVVQIRVSLEEAKAEVMFQPLVITQQELQDQIEDMGFSATLMLK---ETSSGDLTFVQRDLN-------MSIQNTTIWIAGMSCSSCVQSIEGRISQTRGVKSIVVSLKEEKATISFDPGLTEPEQLRAAIEDMGFDASLKEPERSIQNQEKSRSVDFYQQPQSTAAFNHPSGAQPKPDSPKTEIKKCFVLVAGMTCTSCVANIEKNILKHRGIVSVLVSLMAGKAEVKYDAGVLSAPAVAQLIQDLGFGAKLIEDHAGEHGKLDLTITGMTCASCVHKIESKLVATKGILVASVALATRKAHIQFDSEILGPRDIIRIIQSLGFEASLEKKGFKNNV--DHTEE-IRQWRNSFLFSLVFGLPVMGLMVYMMVM-----DTLHQEHGGSMPEDQNVAP----GLSLLNLIFFLLCTPVQIFGGRYFYIQAYRSLKHHTANMDVLIVLATTIAYVYSCLVLVIAMVERASQSPVTFFDTPPMLFVFISLGRWLEHVAKRKTSEALAKLMSLQATDATVVTVGPDHSIISEEQVMVELVQRGDVVKIVPGGKFPIDGKVIEGSSMADESLITGEPMPVSKTVGSLVIAGSINAHGSLLVEATHVGAETTLSQIVKLVEEAQTSKAPIQQFADRISGYFVPFIVFVSLATLVAWLVIGFVNFTIVTENFPGYNQNISKAEVIIRFAFQASITVLSIACPCSLGLATPTAVMVGTGVGAQNGILIKGGEPLEMAHKINVVMFDKTGTITNGVPQVTRVLVLW-ETARMPLRQILAVVGTAEASSEHPLGVAVTKHCKDELGSDAMGFCQDFQAVPGCGISCRVSNVDHLLQQQSFLLP----GATTDESSLLAAQEAPPTVGGA-----------------------SYSVLIGNREWMRRNGLHIKADVDAAMSSHETKGQTAVLVAIDGVLCAMIAIADTVKPESALAVHTLNSMGVEVVMVTGDNRCTAKAIAAQVGIRKVFAEVLPSHKVAKVQELQ--------ERGLRVAMVGDGINDSPALACADVGIAIGTGTDVAIEAADIVLIRNNLLDVVASIELSKKTVRRIRINFVFALIYNLLGIPIAAGVFMPVGLVLQPWMGSAAMAASSVSVVLSSLLLRTYRKTSAESYQSRSHMR----RSLRSSQISAHLGLD 1277          

Query:  100 GSARMKVDGMTCMSCVRNIEENLMKFTGVCGIMVSLLHAEATVIFDADIATVEDISNKIDEMGFDVTVKSSEVSNVKDKVVRSRIKFESDINKSVEKSIETSLSSKLLLVRFCQENNYADIWHYSSIRSTEILSVIQQSEIYGVLVLEQCPTIRVIVRVNGMTCQSCVDNIESTVGKKQGIISIKVFLEKSEAHALVDASLAGPD-VEEMINDMGFNSEM-----------------------ILEIFNDSCAGKPNNVSQKYEELKSNTIYPILSTTIVIKALKSIFCIFKIENHMRALPGVDKCSVNLIEEIGMIDYDSGKWNVQKIREEIESLGYLTELPKQNWNSTRQSSAVSLNEESRSKCYLRITGMTCSSCVNKVESHLLKVEGVKSVLVALLAMKCEIIYDSAYVMPFQLSNRVKELGFNAEVIENG 1332
             + +MKVDGM C SCV +IE  + +  GV  I VSL  A+A V+F   + T +++ ++I++MGF  T+   E S+     V      + D+N S++ +                      IW                                    + GM+C SCV +IE  + + +G+ SI V L++ +A    D  L  P+ +   I DMGF++ +                           FN     +P   S K E         I    +++  +    C+  IE ++    G+    V+L+     + YD+G  +   + + I+ LG+  +L             +  +     K  L ITGMTC+SCV+K+ES L+  +G+    VAL   K  I +DS  + P  +   ++ LGF A + + G
Sbjct:  154 AAVQMKVDGMHCRSCVESIERRIRELPGVVQIRVSLEEAKAEVMFQPLVITQQELQDQIEDMGFSATLMLKETSSGDLTFV------QRDLNMSIQNTT---------------------IW------------------------------------IAGMSCSSCVQSIEGRISQTRGVKSIVVSLKEEKATISFDPGLTEPEQLRAAIEDMGFDASLKEPERSIQNQEKSRSVDFYQQPQSTAAFNHPSGAQPKPDSPKTE---------IKKCFVLVAGMTCTSCVANIEKNILKHRGIVSVLVSLMAGKAEVKYDAGVLSAPAVAQLIQDLGFGAKL-------------IEDHAGEHGKLDLTITGMTCASCVHKIESKLVATKGILVASVALATRKAHIQFDSEILGPRDIIRIIQSLGFEASLEKKG 503          

Query:   85 IRMKLGSARMKVDGMTCMSCVRNIEENLMKFTGVCGIMVSLLHAEATVIFDADIATVEDISNKIDEMGFDVTVKSSEVSNVKDKVVRSRIKFESDINKSVEKSIETSLSSKLLLVRFCQENNYADIWHYSSIRSTEILSVIQQSEIYGVLVLEQCPTIRVIVRVNGMTCQSCVDNIESTVGKKQGIISIKVFLEKSEAHALVDAS-LAGPDVEEMINDMGFNSEMILEIFNDSCAGKPNNVSQKYEELKSNTIYPILSTTIVIKALKSIFCIFKIENHMRALPGVDKCSVNLIEEIGMIDYDSGKWNVQKIREEIESLGYLTELPKQNWNS 1074
            + M + +  + + GM+C SCV++IE  + +  GV  I+VSL   +AT+ FD  +   E +   I++MGFD ++K  E S    +  RS                          V F Q+      +++ S    +  S   ++EI    VL           V GMTC SCV NIE  + K +GI+S+ V L   +A    DA  L+ P V ++I D+GF +++I     +  AG+   +                   + I  +    C+ KIE+ + A  G+   SV L      I +DS     + I   I+SLG+   L K+ + +
Sbjct:  238 LNMSIQNTTIWIAGMSCSSCVQSIEGRISQTRGVKSIVVSLKEEKATISFDPGLTEPEQLRAAIEDMGFDASLKEPERSIQNQEKSRS--------------------------VDFYQQPQSTAAFNHPSGAQPKPDS--PKTEIKKCFVL-----------VAGMTCTSCVANIEKNILKHRGIVSVLVSLMAGKAEVKYDAGVLSAPAVAQLIQDLGFGAKLI-----EDHAGEHGKLD------------------LTITGMTCASCVHKIESKLVATKGILVASVALATRKAHIQFDSEILGPRDIIRIIQSLGFEASLEKKGFKN 506          

Query: 1087 SAVSLNEESRSKCYLRITGMTCSSCVNKVESHLLKVEGVKSVLVALLAMKCEIIYDSAYVMPFQLSNRVKELGFNAEVIENGNEGIGIVNVLIRGMTCSSCVNHIENHISKIKGIASINVSLSTSKGKVEYFISECGPRDVIDAINDMGFDASL 1548
            S +  + ++ S    ++ G+  S+ +  VE+ L  ++GV +V   +     ++ YDS+     +++ +++ LG   E           V + + GM C SCV  IE  I ++ G+  I VSL  +K +V +       +++ D I DMGF A+L
Sbjct:   79 SELCTSPKAASTATFKLFGL--STALEAVETTLPALDGVLAVTWLVPDALVQVDYDSSATTTKEIAMQLQALGCTVE---------AAVQMKVDGMHCRSCVESIERRIRELPGVVQIRVSLEEAKAEVMFQPLVITQQELQDQIEDMGFSATL 221          

Query:   88 RMKLGSARMKVDGMTCMSCVRNIEENLMKFTGVCGIMVSLLHAEATVIFDADIATVEDISNKIDEMGFDVTVKSSEVSNVKDKVVRSRIKFESDINKSVEKSIETSLSSKLLLVRFCQENNYADIWHYSSIRSTEILSVIQQSEIYGVLVLEQCPTIR--------VIVRVNGMTCQSCVDNIESTVGKKQGIISIKVFLEKSEAHALVDASL-AGPDVEEMINDMGFN------------SEMILEIFNDSCAGKPNNVSQKYEELKSNTIYPILSTTIVIKALKSIFC---IFKIENHMRALPGVDKCSVNLIEEIGMIDYDSGKWNVQKIREEIESL---GYLTELP---------KQNWNSTRQSSAVSLN----EESRSKCYLRITGMTCSSCVNKVESHLLKVEGVKS----------------------------------------------------VLVALLAMKCEIIYDSAYVMPFQLSNRVKELGFNAEVIENGNEGIGIVNVLIRGMTCSSCVNHIENHISKIKGIASINVSLSTSKGKVEYFISECGPRDVIDAINDMGFDASLCDHLESNHAAADHINQMIKQWRSSFFFSLICGIPXXXXXXXXXXXXXXXXHTIIHENGS--NRTIMKSTVPM---VCSGLSADNLILFVLATPVQFYGARYFYIQAYLSLKHKTTNMDVLVVMATXXXXXXXXXXXXXXMAFRRNTSPKTFFETSPMLIVFLSLGRWLEHIAKGKTSEALTKLMSLQAVEATLYT--PEN---KERKIPINLVQRNDLIKILPGEKIPVDGKVVTGTSTCDESLITGESMPIEKTHGSDVIGGSINKSGMLIVKATHVGSDSALAQIVKLVEEAQTSKAPIQQLADRIAGMFVPSVLICAIITLIIWVIVGFSK----PEILPKYVNELSVTEITWEHAFQLAITVLSIACPCSLGLXXXXXXXXXXXXXXXNGILIKGGEPLENIHKLNVIVFDKTGTITNGSPSVTRFLVLIGNGVREHIDKLLKILAAAESASEHPIGKAIITFSKARISNENLPEVLESSAVSGCGLGCKLNLDPKTEVTKFVKNLINIESPSEETNILGQXXXXXXXXXXXXTYKDVIFPVRQHMAWTSDLCQTVTVIIGNRNWMLRNGILVDDEVDELMSEDENLGRTVILMAI-DNELIAMISVADQVKREAALAVYTLKKMNIEVYLMTGDNSKTATAIARQVGIHYVFAEVLPSHKVAKVQQLQNTNRSLTSKRKMKVAMVGDGINDSPALAQSDVGIAIGTGTDVAVEAADVVLIRNSLLDVIAAIQLSKATVKRIRQNFIAATLYNLLGIPIAAGVLMPIGIEMMPWMXXXXXXXXXXXXXXXXXXXXXWKKPSEEKL 3930
            ++ L S  +KV+GMTC SCV++IE+ +    GV  I VSL    AT+IFD    + E +S  I++MGF+ +      + V      +++   S +  +  +     LS    ++  C+  +  D+ H +   S  ++S ++ S++   L L    T +        + +RV GMTC SCV  IE  +GK  GI  +KV LE  EA  +    L     + E I   GF             S   +E F DS      + S++ E          + TT+V+  +K + C   +  I++++  LPGV    V+L +E   I YD  K  V  +++ IE+L    +  E P         +    S  Q+   +L     +   S   + I GMTC+SCV  +E  + + +GV S                                                    VLVAL+A K E+ Y+   + P ++   VKELGF A V+EN       + +++RGMTC+SCV+ IE+++ K KGI   +V+L+T+   +++     GPRD+I  I ++GF ASL    + + +  DH ++ I+QWR SF  SLI  +P M +M++ M     +  +  H N +  +R    ST+ +   +  GLS  NL+ F+   PVQF G RYFYIQAY +LKHK+ NMDVL+V+ATS+++ YS++V++++M  R   +P TFF+T PML VF+SLGRWLE IAK KTSEAL+KLMSLQA EAT+     +N    E ++ + LVQR D++K++PG K PVDG+V+ G S  DESLITGE+MP+ K  GS VI GSIN++G L+V ATHVG D+ L+QIVKLVEEAQTSKAPIQQ AD+I+G FVP ++  +++TLI+W+I+GF       +  P Y   +S TE     AFQ +ITVL IACPC LGLATPTAVMVGTGVGA NGILIKGGEPLE  HK+  IVFDKTGTIT G+P V +   ++  G +  + +LL I+  AE+ SEHP+G AI  + K  +  E+L    +  AV GCG+ C+++ + +T V +        +S SE+ N     +    +     +   +I   +   +  +DL     V+IGNR WM RN + +  E+DE M E E  GRT +L+++  + L AMI+++D VK EA LAV TL  M +EV LMTGDNSKTA  IA QVGI  VFAEVLPSHKVAKV+QLQ   +         VAMVGDG+NDSPALA +DVGIAIGTGTDVA+EAADVVLIRN LLDV+ +I LSK TVKRIR NF+ A +YNL+GIPIAAGV +PIG+ + PWM SAAMA SSVSVV  SLLLK + KP+ EKL
Sbjct:    4 KVNLCSVALKVEGMTCGSCVQSIEQRIGSLPGVIHIRVSLEQKTATLIFDQGQQSPESLSEAIEDMGFESSFPDGSTATVVS--TETQLIPTSALAPAAHQEAREKLSQTKGVLEVCESPSQKDL-HITFAPS--LISTLELSKVVESLTLADVQTSKMKDDGVALLKLRVEGMTCHSCVTTIEGKIGKLNGIQKVKVVLESKEATIIYLPYLITHQSIVEQIAFAGFKASVKSKPKPLQLSNRDIERFADSQKATLTSPSEETEVF--------IDTTLVLLGVKGMHCRSCVVNIQDNISLLPGVSSVEVSLEKEQATICYDPHKVTVSALQQAIEALPPGNFKVEAPGSTNPVTSARAQPASVTQAKPAALQPCCTQPLVSTVNIHIEGMTCNSCVQSIEGMISQRKGVVSAQVSLADHQGIFEYDPLLTSPQELREAVEDMGFDAFLPGKSKKSGKGLWIYFVLVALMASKAEVRYNPEVIDPPRIVECVKELGFTASVMENYEGSDRNLELVVRGMTCASCVHKIESNLMKEKGIEYASVALATNIAHIKFDSEVLGPRDIIKLIENLGFKASLVKR-DRSASHLDH-SKEIRQWRKSFLISLIFCVPVMGMMIYMMVMDHHMNASH-HHNATVEDRNHYHSTMFLERQLFPGLSIMNLLSFIFCVPVQFIGGRYFYIQAYKALKHKSANMDVLIVLATSVAFSYSLVVLIVAMVERAKVNPITFFDTPPMLFVFISLGRWLEQIAKSKTSEALSKLMSLQATEATVVALGSDNVILSEEQVDVELVQRGDVVKVVPGGKFPVDGRVLEGHSMADESLITGEAMPVTKKPGSTVIAGSINQNGSLLVSATHVGMDTTLSQIVKLVEEAQTSKAPIQQYADKISGYFVPFIVAVSLLTLIVWIIIGFLDFSLVKKYFPGYDKSISTTETVIRFAFQTSITVLCIACPCCLGLATPTAVMVGTGVGAQNGILIKGGEPLEMAHKVQAIVFDKTGTITYGAPKVVQVKTVV-EGNKMPLSRLLAIVGTAENNSEHPLGAAITKYCKQELGTESLGTCTDFQAVPGCGVRCQVS-NTETVVKQG-------DSDSEDNNHWNSVLVQISDTRTSSSSHPLIMDPQPLSSGPTDL---YVVLIGNREWMRRNFLEITAEIDEAMMEHERRGRTAVLVSLCADMLCAMIAISDTVKPEAELAVQTLTNMGLEVVLMTGDNSKTARVIAAQVGIRKVFAEVLPSHKVAKVEQLQQAGKI--------VAMVGDGVNDSPALAMADVGIAIGTGTDVAIEAADVVLIRNDLLDVVGSIDLSKKTVKRIRINFVFALIYNLVGIPIAAGVFLPIGLVLQPWMGSAAMALSSVSVVVSSLLLKCYTKPTAEKL 1355          

Query: 3250 DELMSEDENLGRTVILMAIDNELIAMISVADQVKREAALAVYTLKKMNIEVYLMTGDNSKTATAIARQVGIH-------------------------------YVFAEVLPSHKVAKVQQLQNTNRSLTSKRKMKVAMVGDGINDSPALAQSDVGIAIGTGTDVAVEAADVVLIRNSLLDVIAAIQLSKATVKRIRQ 3747
            D L+ ED       I    D   +  + + D  + E A ++   +   I V ++TGDN  TA AI R++GI                                  FA V P+HK   V+ LQ+ +           AM GDG+ND+PAL +S++GIA+G+GT VA  A+++VL  ++   ++AA++  +A    ++Q
Sbjct:  572 DRLVLEDST---RFIEYETDLTFVGCVGMLDPPRAEVAASIRLCRLAGIRVIMITGDNKGTAVAICRRIGIFGEEDDVSSMAFTGREFDDLSPAAQREAVVKARCFARVEPAHKSKIVEYLQSYDEI--------TAMTGDGVNDAPALKKSEIGIAMGSGTAVAKSASEMVLADDNFATIVAAVEEGRAIYNNMKQ 757          

Query: 3250 DELMSEDENLGRTVILMAIDNELIAMISVADQVKREAALAVYTLKKMNIEVYLMTGDNSKTATAIARQVGIH-------------------------------YVFAEVLPSHKVAKVQQLQNTNRSLTSKRKMKVAMVGDGINDSPALAQSDVGIAIGTGTDVAVEAADVVLIRNSLLDVIAAIQLSKATVKRIRQ 3747
            D L+ ED       I    D   +  + + D  + E A ++   +   I V ++TGDN  TA AI R++GI                                  FA V P+HK   V+ LQ+ +           AM GDG+ND+PAL +S++GIA+G+GT VA  A+++VL  ++   ++AA++  +A    ++Q
Sbjct:  572 DRLVLEDST---RFIEYETDLTFVGCVGMLDPPRAEVAASIRLCRLAGIRVIMITGDNKGTAVAICRRIGIFGEEDDVSSMAFTGREFDDLSPAAQREAVVKARCFARVEPAHKSKIVEYLQSYDEI--------TAMTGDGVNDAPALKKSEIGIAMGSGTAVAKSASEMVLADDNFATIVAAVEEGRAIYNNMKQ 757          

Query:   91 MKLGSARMKVDGMTCMSCVRNIEENLMKFTGVCGIMVSLLHAEATVIFDADIATVEDISNKIDEMGFDVTVKSSEVSNVKDKVVRSRIKFESDINKSVEKSIETSLSSKLLLVRFCQENNYADIWHYSSIRSTEILSVIQQSEIYGVLVLEQCPTIRVIVRVNGMTCQSCVDNIESTVGKKQGIISIKVFLEKSEAHALVDASLAGPDVEEMINDMGFNSEMILEIFNDSCAGKPNNVSQKYEELKSNTIYPILSTTIVIKALKSIFCIFKIENHMRALPGVDKCSVNLIEEIGMIDYDSGKWNVQKIREEIESLGYLTELPKQNWNSTRQSSAVSLNEESRSKCYLRITGMTCSSCVNKVESHLLKVEGVKSVLVALLAMKCEIIYDSAYVMPFQLSNRVKELGFNAEVIENGNEGIGIVNVLIRGMTCSSCVNHIENHISKIKGIASINVSLSTSKGKVEYFISECGPRDVIDAINDMGFDASLCDHLESNHAAADHINQMIKQWRSSFFFSLICGIPXXXXXXXXXXXXXXXXHTIIHENGSNRTIMKSTVPMVCSGLSADNLILFVLATPVQFYGARYFYIQAYLSLKHKTTNMDVLVVMATXXXXXXXXXXXXXXMAFRRNTSPKTFFETSPMLIVFLSLGRWLEHIAKGKTSEALTKLMSLQAVEATLYTPENKERKIPINLVQRNDLIKILPGEKIPVDGKVVTGTSTCDESLITGESMPIEKTHGSDVIGGSINKSGMLIVKATHVGSDSALAQIVKLVEEAQTSKAPIQQLADRIAGMFVPSVLICAIITLIIWVIVGFSKPEILPKYVNELSVTEITWEHAFQLAITVLSIACPCSLGLXXXXXXXXXXXXXXXNGILIKGGEPLENIHKLNVIVFDKTGTITNGSPSVTRFLVLIGNGVREHIDKLLKILAAAESASEHPIGKAIITFSKARISNENLPEVLESSAVSGCGLGCKLNLDPKTEVTKFVKNLINIESPSEETNILGQXXXXXXXXXXXXTYKDVIFPVRQHMAWTSDLCQTVTVIIGNRNWMLRNGILVDDEVDELMSEDENLGRTVILMAIDNELIAMISVADQVKREAALAVYTLKKMNIEVYLMTGDNSKTATAIARQVGIHYVFAEVLPSHKVAKVQQLQNTNRSLTSKRKMKVAMVGDGINDSPALAQSDVGIAIGTGTDVAVEAADVVLIRNSLLDVIAAIQLSKATVKRIRQNFIAATLYNLLGIPIAAGVLMPIGIEMMPWMXXXXXXXXXXXXXXXXXXXXXWKKPSEEKLITPEYINFIQSSGLSESQIIVRRGIDLMTPQIETTSSLKGSVKSVLGKLNFSNKSKHKSDKLDSCRFLRNSDRTKVSTSTEESDIDIEIGLLSKNKLDLDLTTNM 4245
            MKLGSARMKVDGMTCMSCVRNIEENLMKFTGVCGIMVSLL AEATVIFDADIATVEDISNKIDEMGFDVTVKSSEVSNVKDKVVRSRIKFESDINKSVEKSIETSLSSKLLLVRFCQENNYADIWHYSSIRSTEILSVIQQSEIYGVLVLEQCPTIRVIVRVNGMTCQSCVDNIESTVGKKQGIISIKVFLEKSEAHALVDASLAGPDVEEMINDMGFNSEMILEIFNDSCAGKPNNVSQKYEELKSNTIYPILSTTIVIKALKSIFCIFKIENHMRALPGVDKCSVNLIEEIGMIDYDSGKWNVQKIREEIESLGYLTELPKQNWNSTRQSSAVSLNEESRSKCYLRITGMTCSSCVNKVESHLLKVEGVKSVLVALLAMKCEIIYDSAYVMPFQLSNRVKELGFNAEVIENGNEGIG+VNVLIRGMTCSSCVNHIENHISKIKGIASINVSLSTSKGKVEYFISECGPRDVIDAINDMGFDASLCDHLESNHAAADHINQMIKQWRSSFFFSLICGIPTMFVMMFTMFNFKMVKHTIIHENGSNRTIM+STVPMVCSGLSADNLILFVLATPVQFYGARYFYIQAYLSLKHKTTNMDVLVVMATSISYIYSVIVIVISMAFRRNTSPKTFFETSPMLIVFLSLGRWLEHIAKGKTSEALTKLMSLQAVEATLYTPENKERKIPINLVQRNDLIKILPGEKIPVDGKVVTGTSTCDESLITGESMPIEKTHGSDVIGGSINKSGMLIVKATHVGSDSALAQIVKLVEEAQTSKAPIQQLADRIAGMFVPSVLICAIITLIIWVIVGFSKPEILPKYVNELSVTEITWEHAFQLAITVLSIACPCSLGLATPTAVMVGTGVGAVNGILIKGGEPLENIHKLNVIVFDKTGTITNGSPSVTRFLVLIGNGVREHIDKLLKILAAAESASEHPIGKAIITFSKARISNENLPEVLESSAVSGCGLGCKLNLDPKTEVTKFVKNLINIESPSEETNILGQNMNININDDIRITYKDVIFPVRQHMAWTSDLCQTVTVIIGNRNWM RNGILVDDEVDELMSEDENLGRTVILMAIDNELIAMISVADQVKREAALAVYTLKKMNIEVYLMTGDNSKTATAIARQVGIHYVFAEVLPSHKVAKVQQLQNTNRSLTSKRKMKVAMVGDGINDSPALAQSDVGIAIGTGTDVAVEAADVVLIRNSLLDVIAAIQLSKATVKRIRQNFIAATLYNLLGIPIAAGVLMPIGIEMMPWMASAAMAASSVSVVTLSLLLKLWKKPSEEKLITPEYINFIQSSGLSESQIIVRRGIDLMTPQIETTSSLKGSVKSVLGKLNFSNKSKHKSDKLDSCR LRNSDRTKVSTSTEESDIDIEIGLLS+NKLDLDLTTNM
Sbjct:    1 MKLGSARMKVDGMTCMSCVRNIEENLMKFTGVCGIMVSLLQAEATVIFDADIATVEDISNKIDEMGFDVTVKSSEVSNVKDKVVRSRIKFESDINKSVEKSIETSLSSKLLLVRFCQENNYADIWHYSSIRSTEILSVIQQSEIYGVLVLEQCPTIRVIVRVNGMTCQSCVDNIESTVGKKQGIISIKVFLEKSEAHALVDASLAGPDVEEMINDMGFNSEMILEIFNDSCAGKPNNVSQKYEELKSNTIYPILSTTIVIKALKSIFCIFKIENHMRALPGVDKCSVNLIEEIGMIDYDSGKWNVQKIREEIESLGYLTELPKQNWNSTRQSSAVSLNEESRSKCYLRITGMTCSSCVNKVESHLLKVEGVKSVLVALLAMKCEIIYDSAYVMPFQLSNRVKELGFNAEVIENGNEGIGVVNVLIRGMTCSSCVNHIENHISKIKGIASINVSLSTSKGKVEYFISECGPRDVIDAINDMGFDASLCDHLESNHAAADHINQMIKQWRSSFFFSLICGIPTMFVMMFTMFNFKMVKHTIIHENGSNRTIMRSTVPMVCSGLSADNLILFVLATPVQFYGARYFYIQAYLSLKHKTTNMDVLVVMATSISYIYSVIVIVISMAFRRNTSPKTFFETSPMLIVFLSLGRWLEHIAKGKTSEALTKLMSLQAVEATLYTPENKERKIPINLVQRNDLIKILPGEKIPVDGKVVTGTSTCDESLITGESMPIEKTHGSDVIGGSINKSGMLIVKATHVGSDSALAQIVKLVEEAQTSKAPIQQLADRIAGMFVPSVLICAIITLIIWVIVGFSKPEILPKYVNELSVTEITWEHAFQLAITVLSIACPCSLGLATPTAVMVGTGVGAVNGILIKGGEPLENIHKLNVIVFDKTGTITNGSPSVTRFLVLIGNGVREHIDKLLKILAAAESASEHPIGKAIITFSKARISNENLPEVLESSAVSGCGLGCKLNLDPKTEVTKFVKNLINIESPSEETNILGQNMNININDDIRITYKDVIFPVRQHMAWTSDLCQTVTVIIGNRNWMQRNGILVDDEVDELMSEDENLGRTVILMAIDNELIAMISVADQVKREAALAVYTLKKMNIEVYLMTGDNSKTATAIARQVGIHYVFAEVLPSHKVAKVQQLQNTNRSLTSKRKMKVAMVGDGINDSPALAQSDVGIAIGTGTDVAVEAADVVLIRNSLLDVIAAIQLSKATVKRIRQNFIAATLYNLLGIPIAAGVLMPIGIEMMPWMASAAMAASSVSVVTLSLLLKLWKKPSEEKLITPEYINFIQSSGLSESQIIVRRGIDLMTPQIETTSSLKGSVKSVLGKLNFSNKSKHKSDKLDSCRLLRNSDRTKVSTSTEESDIDIEIGLLSENKLDLDLTTNM 1385          

Query: 1018 EEIESLGYLTELPKQNWNSTRQSSAVSLNEESRSKCYLRITGMTCSSCVNKVESHLLKVEGVKSVLVALLAMKCEIIYDSAYVMPFQLSNRVKELGFNAEVIENGNEGIGIVNVLIRGMTCSSCVNHIENHISKIKGIASINVSLSTSKGKVEYFISECGPRDVIDAINDMGFDASLCDHLESNHAAADHINQMIKQWRSSFFFSLICGIPXXXXXXXXXXXXXXXXHTIIHENGSNRTIMKSTVPMVCSGLSADNLILFVLATPVQFYGARYFYIQAYLSLKHKTTNMDVLVVMATXXXXXXXXXXXXXXMAFRRNTSPKTFFETSPMLIVFLSLGRWLEHIAKGKTSEALTKLMSLQAVEATLYTPENKERKIPINLVQRNDLIKILPGEKIPVDGKVVTGTSTCDESLITGESMPIEKTHGSDVIGGSINKSGMLIVKATHVGSDSALAQIVKLVEEAQTSKAPIQQLADRIAGMFVPSVLICAIITLIIWVIVGFSKPEILPKYVN-ELSVTEITWEHAFQLAITVLSIACPCSLGLXXXXXXXXXXXXXXXNGILIKGGEPLENIHKLNVIVFDKTGTITNGSPSVTRFLVLIGNGVREHIDKLLKILAAAESASEHPIGKAIITFSKARISNENLPEVLESSAVSGCGLGCKLNLD-----PKTEVTKFVKNLINIESPSEETNILGQXXXXXXXXXXXXTYKDVIFPVRQHMAWTSDLCQTVTVIIGNRNWMLRNGILVDDEVDELMSEDENLGRTVILMAIDNELIAMISVADQVKREAALAVYTLKKMNIEVYLMTGDNSKTATAIARQVGIHYVFAEVLPSHKVAKVQQLQNTNR-------SLTSK--RKMKVAMVGDGINDSPALAQSDVGIAIGTGTDVAVEAADVVLIRNSLLDVIAAIQLSKATVKRIRQNFIAATLYNLLGIPIAAGVLMPIGIEMMPWMXXXXXXXXXXXXXXXXXXXXXWKKPSEEKLITPEYINFIQSSGLSESQIIVRRGIDLMTPQIETTSSLKGSVKSVLGKLNFSNKSKHKSDKLDSCRFLRN 4140
            E IE+LG+L        N  +++     N +   KC++RI GMTCSSCV+ +E+ +LK++GVKS L+ LL+   E+ YD   +M   +++ + ++GF+AE+ +       I+ V+I+GMTCSSCV  IE+ +++++GI S+ V+L+T KGK ++      PRD++DAI +MGFDA L    +  +   DH+ + IK+W+ SF  SLI G+PTM VMM  M+ F      I  +NG N T+M S  P++  GLS +NL+LF+ ++PVQFYGARYFY+QAY S+KH + NMDVLVVMATS+SYIYS IVI++SM  R+++SP+TFFET+PMLIVFLSLGRWLEHIAKGKTSEAL+KL+SLQA EAT+   +N+ERKI ++LV++ DL+K+LPGEKIP+DG+VV+G S CDESLITGESM +EK  GSDVIGG++N SGMLI++AT VG DSAL QIVKLVEEAQTSKAPIQ+LAD++AG+FVP V+IC++ TL+IW+ +G++ P +LP + +     TE+ W++AFQLAITVLS+ACPCSLGLATPTAVMVGTGVGA+NGILIKGG PLE +H+L+VIVFDKTGTIT G PSVT F++ + N   +  + +L +L AAES+SEHPIGKAI+ + +       +P+V+ S +VSG GL C L L      P +E+   +  + + +  +   N+           +  + ++ +  PV             V + +GNRN M  N I + D++DELMS DE+ GRTV+LMAID  L+AMIS+ADQVK+EAAL VYTL+KM +EV+L+TGDN KTATAIA+++GI  VFAEVLPSHKVAK+QQ+QN ++       S  SK  +   VAMVGDGINDSPALAQ+DVGIAIGTGTDVAVEAADVVLIRNSLLDVIAA++LSK TV+RIRQNF+AAT+YNL+GIPIAAG LMPIG+  MPWMAS AMAASS+ VV LSLLLKLWKKP+E++L   E+ N ++     + ++ V  G D++ P+ +   S + S+ S+   +  S K  + SD++      +N
Sbjct:   62 EAIENLGFLI-------NKNKETD----NTKELFKCHMRIQGMTCSSCVHTIENQVLKLKGVKSALINLLSTIGEVTYDPDLIMASDIADTINDMGFDAEIFQFKEHTKDIIEVMIQGMTCSSCVYTIESKLAQMQGILSVKVALTTEKGKFKFDPQIISPRDILDAIEEMGFDAKLAP--KKTNKYNDHVGESIKKWKHSFLISLIFGVPTMIVMMVFMYGFSHRMQVIHLKNGINVTVMVSNAPILFPGLSLENLLLFLFSSPVQFYGARYFYVQAYKSIKHGSANMDVLVVMATSVSYIYSFIVILVSMILRQDSSPQTFFETTPMLIVFLSLGRWLEHIAKGKTSEALSKLLSLQAFEATIIVNDNQERKISVDLVKKGDLVKVLPGEKIPIDGRVVSGKSRCDESLITGESMSVEKIPGSDVIGGTLNISGMLIIRATLVGEDSALNQIVKLVEEAQTSKAPIQELADKVAGLFVPGVIICSMFTLLIWIAIGYTNPNLLPGHSSINTDNTELIWKYAFQLAITVLSVACPCSLGLATPTAVMVGTGVGAINGILIKGGVPLEKMHQLDVIVFDKTGTITTGKPSVTNFVMCVENVTSQIRNCILLMLGAAESSSEHPIGKAILQYVRETCDINEMPQVVHSKSVSGFGLECSLKLQSDMFVPDSEIDNVLVKINDFQENNLTENL----------KETSVKWRKINEPVE------------VVLYLGNRNMMKENHISIPDKLDELMSRDEDNGRTVVLMAIDKVLLAMISIADQVKKEAALVVYTLEKMGVEVFLLTGDNHKTATAIAKEIGIRNVFAEVLPSHKVAKIQQIQNMSKYKRSWLFSCCSKPSKLTNVAMVGDGINDSPALAQADVGIAIGTGTDVAVEAADVVLIRNSLLDVIAAMKLSKDTVRRIRQNFVAATMYNLIGIPIAAGALMPIGVVFMPWMASVAMAASSICVVCLSLLLKLWKKPNEDQLANQEFKNHLECLKYGDMEVGVNLGKDIILPKRKPRRSFRSSISSLWSSMEISKKKPNVSDRIALLENFKN 1082          

Query:  892 CIFKIENHMRALPGVDKCSVNLIEEIGMIDYDSGKWNVQKIREEIESLGYLTELPKQNWNSTRQSSAVSLNEESRSKCYLRITGMTCSSCVNKVESHLLKVEGVKSVLVALLAMKCEIIYDSAYVMPFQLSNRVKELGFNAEV 1320
            C+  IEN +  L GV    +NL+  IG + YD        I + I  +G+  E+                 E ++    + I GMTCSSCV  +ES L +++G+ SV VAL   K +  +D   + P  + + ++E+GF+A++
Sbjct:   98 CVHTIENQVLKLKGVKSALINLLSTIGEVTYDPDLIMASDIADTINDMGFDAEI-------------FQFKEHTKDIIEVMIQGMTCSSCVYTIESKLAQMQGILSVKVALTTEKGKFKFDPQIISPRDILDAIEEMGFDAKL 227          

Query:  568 VRVNGMTCQSCVDNIESTVGKKQGIISIKVFLEKSEAHALVDASL-AGPDVEEMINDMGFNSEMILEIFNDSCAGKPNNVSQKYEELKSNTIYPILSTTIVIKALKSIFCIFKIENHMRALPGVDKCSVNLIEEIGMIDYDSGKWNVQKIREEIESLGYLTELPKQNWN 1071
            +R+ GMTC SCV  IE+ V K +G+ S  + L  +      D  L    D+ + INDMGF++E+                  +++E   + I       ++I+ +    C++ IE+ +  + G+    V L  E G   +D    + + I + IE +G+  +L  +  N
Sbjct:   88 MRIQGMTCSSCVHTIENQVLKLKGVKSALINLLSTIGEVTYDPDLIMASDIADTINDMGFDAEIF-----------------QFKEHTKDII------EVMIQGMTCSSCVYTIESKLAQMQGILSVKVALTTEKGKFKFDPQIISPRDILDAIEEMGFDAKLAPKKTN 233          

Query:   94 KLGSARMKVDGMTCMSCVRNIEENLMKFTGVCGIMVSLLHAEATVIFDADIATVEDISNKIDEMGFDVTV 303
            +L    M++ GMTC SCV  IE  ++K  GV   +++LL     V +D D+    DI++ I++MGFD  +
Sbjct:   82 ELFKCHMRIQGMTCSSCVHTIENQVLKLKGVKSALINLLSTIGEVTYDPDLIMASDIADTINDMGFDAEI 151          

Query:  118 VDGMTCMSCVRNIEENLMKFTGVCGIMVSLLHAEATVIFDADIATVEDISNKIDEMGFDVTVKSSEVSNVKDKVVRSRIKFE 363
            + GMTC SCV  IE  L +  G+  + V+L   +    FD  I +  DI + I+EMGFD  +   + +   D V  S  K++
Sbjct:  166 IQGMTCSSCVYTIESKLAQMQGILSVKVALTTEKGKFKFDPQIISPRDILDAIEEMGFDAKLAPKKTNKYNDHVGESIKKWK 247          

Query: 3316 LIAMISVADQVKREAALAVYTLKKMNIEVYLMTGDNSKTATAIARQVGIH-------------------------------YVFAEVLPSHKVAKVQQLQNTNRSLTSKRKMKV-AMVGDGINDSPALAQSDVGIAIGTGTDVAVEAADVVLIRNSLLDVIAAIQLSKATVKRIRQ---NFIAATLYNLLGIPIAAGVLMP 3813
             + ++ + D  + E   ++   +   I V ++TGDN  TA AI R++GI                                 +FA V P+HK   ++ LQ         R  ++ AM GDG+ND+PAL ++++GIA+G+GT VA  A+D+VL  ++   ++AA++  +A    ++Q     I++ +  ++ I + A + MP
Sbjct:  602 FVGLVGMLDPPRSEVLDSIGACRNAGIRVIVITGDNKATAEAICRRIGIFGEDESTVGKSYTGREFDQLSDFEQRNAVRNASLFARVEPAHKSKIIEHLQ---------RDGEISAMTGDGVNDAPALKKAEIGIAMGSGTAVAKSASDMVLADDNFSTIVAAVEEGRAIYNNMKQFIRYLISSNIGEVVCIFLTAALGMP 793          

Query: 3316 LIAMISVADQVKREAALAVYTLKKMNIEVYLMTGDNSKTATAIARQVGIH-------------------------------YVFAEVLPSHKVAKVQQLQNTNRSLTSKRKMKVAMVGDGINDSPALAQSDVGIAIGTGTDVAVEAADVVLIRNSLLDVIAAIQLSKATVKRIRQ---NFIAATLYNLLGIPIAAGVLMP 3813
            L+ ++ + D  + E   ++    K  I V ++TGDN  TA AI R++G+                                 +FA V P+HK   ++ LQ+             AM GDG+ND+PAL ++++GIA+G+GT VA  A+D+VL  ++   +++A++  +A    ++Q     I++ +  ++ I + A + MP
Sbjct:  593 LVGVVGMLDPPRSEVHDSIKKCYKAGIRVIVITGDNKATAEAICRRIGVFEENETTFGKSFTGREFDELSPEMQLDACRKAKLFARVEPAHKSKIIEYLQSDGHI--------SAMTGDGVNDAPALKKAEIGIAMGSGTAVAKSASDMVLSDDNFSSIVSAVEEGRAIYNNMKQFIRYLISSNIGEVVSIFLTAALGMP 784          

Query: 3316 LIAMISVADQVKREAALAVYTLKKMNIEVYLMTGDNSKTATAIARQVGIH-------------------------------YVFAEVLPSHKVAKVQQLQNTNRSLTSKRKMKVAMVGDGINDSPALAQSDVGIAIGTGTDVAVEAADVVLIRNSLLDVIAAIQLSKATVKRIRQ---NFIAATLYNLLGIPIAAGVLMP 3813
            L+ ++ + D  + E   ++    K  I V ++TGDN  TA AI R++G+                                 +FA V P+HK   ++ LQ+             AM GDG+ND+PAL ++++GIA+G+GT VA  A+D+VL  ++   +++A++  +A    ++Q     I++ +  ++ I + A + MP
Sbjct:  590 LVGVVGMLDPPRSEVHDSIKKCYKAGIRVIVITGDNKATAEAICRRIGVFEENETTFGKSFTGREFDELSPEMQLDACRKAKLFARVEPAHKSKIIEYLQSDGHI--------SAMTGDGVNDAPALKKAEIGIAMGSGTAVAKSASDMVLSDDNFSSIVSAVEEGRAIYNNMKQFIRYLISSNIGEVVSIFLTAALGMP 781